Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	V	K	T	Q	R	V	V	I	T	P	G	E	P	A	G	I	G	P	D	L	V	V	Q	L	A	Q	R	E	W	P	V	E	L	V	V	C	A	D	A	T	L	L	T	N	R	A	A	M	L	G	L	P	L	T	L	R	P	Y	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	N	S	P	A	Q	P	Q	T	A	G	T	L	T	L	L	P	V	A	L	R	A	P	V	T	A	G	Q	L	A	V	E	N	G	H	Y	V	V	E	T	L	A	R	A	C	D	G	C	L	N	G	E	F	A	A	L	I	T	G	P
Secondary structure
SS confidence
Disorder					?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	H	K	G	V	I	N	D	A	G	I	P	F	T	G	H	T	E	F	F	E	E	R	S	Q	A	K	K	V	V	M	M	L	A	T	E	E	L	R	V	A	L	A	T	T	H	L	P	L	R	D	I	A	D	A	I	T	P	A	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	H	E	V	I	A	I	L	H	H	D	L	R	T	K	F	G	I	A	E	P	R	I	L	V	C	G	L	N	P	H	A	G	E	G	G	H	M	G	T	E	E	I	D	T	I	I	P	V	L	N	E	L	R	A	Q	G	M	K	L
Secondary structure
SS confidence
Disorder																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	G	P	L	P	A	D	T	L	F	Q	P	K	Y	L	D	N	A	D	A	V	L	A	M	Y	H	D	Q	G	L	P	V	L	K	Y	Q	G	F	G	R	G	V	N	I	T	L	G	L	P	F	I	R	T	S	V	D	H	G	T	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.
Sequence		L	E	L	A	G	R	G	K	A	D	V	G	S	F	I	T	A	L	N	L	A	I	K	M	I	V	N	T	Q
Secondary structure
SS confidence
Disorder																											?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1r8k chain A Region: 3 - 329 Aligned: 327 Modelled: 327 Confidence: 100.0% Identity: 91% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: PdxA-like Phyre2 PDB 1ptm chain A Region: 2 - 329 Aligned: 328 Modelled: 328 Confidence: 100.0% Identity: 98% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: PdxA-like Phyre2 PDB 2hi1 chain A Region: 3 - 325 Aligned: 320 Modelled: 323 Confidence: 100.0% Identity: 36% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:4-hydroxythreonine-4-phosphate dehydrogenase 2; PDBTitle: the structure of a putative 4-hydroxythreonine-4-phosphate2 dehydrogenase from salmonella typhimurium. Phyre2 PDB 1yxo chain B Region: 6 - 328 Aligned: 323 Modelled: 320 Confidence: 100.0% Identity: 60% PDB header:oxidoreductase Chain: B: PDB Molecule:4-hydroxythreonine-4-phosphate dehydrogenase 1; PDBTitle: crystal structure of pyridoxal phosphate biosynthetic protein pdxa2 pa0593 Phyre2 PDB 1u7n chain A Region: 5 - 328 Aligned: 272 Modelled: 284 Confidence: 100.0% Identity: 16% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: PlsX-like Phyre2 PDB 1vi1 chain A Region: 6 - 328 Aligned: 276 Modelled: 297 Confidence: 100.0% Identity: 14% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: PlsX-like Phyre2 PDB 2iv0 chain A Region: 1 - 323 Aligned: 292 Modelled: 297 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:isocitrate dehydrogenase; PDBTitle: thermal stability of isocitrate dehydrogenase from2 archaeoglobus fulgidus studied by crystal structure3 analysis and engineering of chimers Phyre2 PDB 1xco chain A Region: 3 - 325 Aligned: 276 Modelled: 305 Confidence: 100.0% Identity: 15% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Phosphotransacetylase Phyre2 PDB 1yco chain A Region: 6 - 327 Aligned: 255 Modelled: 288 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:branched-chain phosphotransacylase; PDBTitle: crystal structure of a branched-chain phosphotransacylase from2 enterococcus faecalis v583 Phyre2 PDB 2af4 chain C domain 1 Region: 4 - 325 Aligned: 282 Modelled: 304 Confidence: 100.0% Identity: 10% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Phosphotransacetylase Phyre2 PDB 1r5j chain A Region: 3 - 325 Aligned: 277 Modelled: 299 Confidence: 100.0% Identity: 13% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Phosphotransacetylase Phyre2 PDB 1tyo chain A Region: 3 - 320 Aligned: 288 Modelled: 291 Confidence: 99.9% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:isocitrate dehydrogenase; PDBTitle: isocitrate dehydrogenase from the hyperthermophile aeropyrum pernix in2 complex with etheno-nadp Phyre2 PDB 3tng chain A Region: 3 - 326 Aligned: 256 Modelled: 291 Confidence: 99.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:lmo1369 protein; PDBTitle: the crystal structure of a possible phosphate acetyl/butaryl2 transferase from listeria monocytogenes egd-e. Phyre2 PDB 1vmi chain A Region: 3 - 322 Aligned: 269 Modelled: 289 Confidence: 99.9% Identity: 17% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Phosphotransacetylase Phyre2 PDB 1vmi chain A Region: 3 - 322 Aligned: 269 Modelled: 281 Confidence: 99.9% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:putative phosphate acetyltransferase; PDBTitle: crystal structure of putative phosphate acetyltransferase2 (np_416953.1) from escherichia coli k12 at 2.32 a resolution Phyre2 PDB 1wpw chain A Region: 6 - 323 Aligned: 250 Modelled: 261 Confidence: 98.7% Identity: 14% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 1cnz chain A Region: 1 - 323 Aligned: 262 Modelled: 274 Confidence: 98.7% Identity: 17% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 1a05 chain A Region: 5 - 323 Aligned: 252 Modelled: 276 Confidence: 98.6% Identity: 18% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 1cm7 chain A Region: 1 - 323 Aligned: 262 Modelled: 276 Confidence: 98.6% Identity: 19% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 3r8w chain C Region: 3 - 323 Aligned: 260 Modelled: 274 Confidence: 98.6% Identity: 18% PDB header:oxidoreductase Chain: C: PDB Molecule:3-isopropylmalate dehydrogenase 2, chloroplastic; PDBTitle: structure of 3-isopropylmalate dehydrogenase isoform 2 from2 arabidopsis thaliana at 2.2 angstrom resolution Phyre2 1 d1r8ka_ 2 d1ptma_ 3 c2hi1A_ 4 c1yxoB_ 5 d1u7na_ 6 d1vi1a_ 7 c2iv0A_ 8 d1xcoa_ 9 c1ycoA_ 10 d2af4c1 11 d1r5ja_ 12 c1tyoA_ 13 c3tngA_ 14 d1vmia_ 15 c1vmiA_ 16 d1wpwa_ 17 d1cnza_ 18 d1a05a_ 19 d1cm7a_ 20 c3r8wC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1r8ka_ 100.0 91 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:PdxA-like 2 d1ptma_ 100.0 98 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:PdxA-like 3 c2hi1A_ 100.0 36 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:4-hydroxythreonine-4-phosphate dehydrogenase 2; PDBTitle: the structure of a putative 4-hydroxythreonine-4-phosphate2 dehydrogenase from salmonella typhimurium. 4 c1yxoB_ 100.0 60 PDB header:oxidoreductase Chain: B: PDB Molecule:4-hydroxythreonine-4-phosphate dehydrogenase 1; PDBTitle: crystal structure of pyridoxal phosphate biosynthetic protein pdxa2 pa0593 5 d1u7na_ 100.0 16 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:PlsX-like 6 d1vi1a_ 100.0 14 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:PlsX-like 7 c2iv0A_ 100.0 18 PDB header:oxidoreductase Chain: A: PDB Molecule:isocitrate dehydrogenase; PDBTitle: thermal stability of isocitrate dehydrogenase from2 archaeoglobus fulgidus studied by crystal structure3 analysis and engineering of chimers 8 d1xcoa_ 100.0 15 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Phosphotransacetylase 9 c1ycoA_ 100.0 18 PDB header:transferase Chain: A: PDB Molecule:branched-chain phosphotransacylase; PDBTitle: crystal structure of a branched-chain phosphotransacylase from2 enterococcus faecalis v583 10 d2af4c1 100.0 10 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Phosphotransacetylase 11 d1r5ja_ 100.0 13 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Phosphotransacetylase 12 c1tyoA_ 99.9 14 PDB header:oxidoreductase Chain: A: PDB Molecule:isocitrate dehydrogenase; PDBTitle: isocitrate dehydrogenase from the hyperthermophile aeropyrum pernix in2 complex with etheno-nadp 13 c3tngA_ 99.9 13 PDB header:transferase Chain: A: PDB Molecule:lmo1369 protein; PDBTitle: the crystal structure of a possible phosphate acetyl/butaryl2 transferase from listeria monocytogenes egd-e. 14 d1vmia_ 99.9 17 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Phosphotransacetylase 15 c1vmiA_ 99.9 17 PDB header:transferase Chain: A: PDB Molecule:putative phosphate acetyltransferase; PDBTitle: crystal structure of putative phosphate acetyltransferase2 (np_416953.1) from escherichia coli k12 at 2.32 a resolution 16 d1wpwa_ 98.7 14 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 17 d1cnza_ 98.7 17 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 18 d1a05a_ 98.6 18 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 19 d1cm7a_ 98.6 19 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 20 c3r8wC_ 98.6 18 PDB header:oxidoreductase Chain: C: PDB Molecule:3-isopropylmalate dehydrogenase 2, chloroplastic; PDBTitle: structure of 3-isopropylmalate dehydrogenase isoform 2 from2 arabidopsis thaliana at 2.2 angstrom resolution 21 c3u1hA_ not modelled 98.6 17 PDB header:oxidoreductase Chain: A: PDB Molecule:3-isopropylmalate dehydrogenase; PDBTitle: crystal structure of ipmdh from the last common ancestor of bacillus 22 c3blxL_ not modelled 98.5 18 PDB header:oxidoreductase Chain: L: PDB Molecule:isocitrate dehydrogenase [nad] subunit 2; PDBTitle: yeast isocitrate dehydrogenase (apo form) 23 d1g2ua_ not modelled 98.4 18 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 24 d1xaca_ not modelled 98.4 17 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 25 d1v53a1 not modelled 98.3 18 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 26 d1hqsa_ not modelled 98.3 21 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 27 d1vlca_ not modelled 98.1 16 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 28 c2d1cB_ not modelled 97.4 18 PDB header:oxidoreductase Chain: B: PDB Molecule:isocitrate dehydrogenase; PDBTitle: crystal structure of tt0538 protein from thermus thermophilus hb8 29 c3blxM_ not modelled 96.9 20 PDB header:oxidoreductase Chain: M: PDB Molecule:isocitrate dehydrogenase [nad] subunit 1; PDBTitle: yeast isocitrate dehydrogenase (apo form) 30 c2d4vD_ not modelled 96.9 27 PDB header:oxidoreductase Chain: D: PDB Molecule:isocitrate dehydrogenase; PDBTitle: crystal structure of nad dependent isocitrate dehydrogenase2 from acidithiobacillus thiooxidans 31 c2e0cA_ not modelled 96.8 30 PDB header:oxidoreductase Chain: A: PDB Molecule:409aa long hypothetical nadp-dependent isocitrate PDBTitle: crystal structure of isocitrate dehydrogenase from sulfolobus tokodaii2 strain7 at 2.0 a resolution 32 d1w0da_ not modelled 96.7 26 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 33 c3fmxX_ not modelled 96.6 23 PDB header:oxidoreductase Chain: X: PDB Molecule:tartrate dehydrogenase/decarboxylase; PDBTitle: crystal structure of tartrate dehydrogenase from pseudomonas2 putida complexed with nadh 34 d1pb1a_ not modelled 96.6 26 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 35 c1x0lB_ not modelled 95.7 24 PDB header:oxidoreductase Chain: B: PDB Molecule:homoisocitrate dehydrogenase; PDBTitle: crystal structure of tetrameric homoisocitrate dehydrogenase from an2 extreme thermophile, thermus thermophilus 36 c2qfyE_ not modelled 92.3 13 PDB header:oxidoreductase Chain: E: PDB Molecule:isocitrate dehydrogenase [nadp]; PDBTitle: crystal structure of saccharomyces cerevesiae mitochondrial nadp(+)-2 dependent isocitrate dehydrogenase in complex with a-ketoglutarate 37 d1t0la_ not modelled 91.7 13 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 38 d1lwda_ not modelled 91.6 16 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 39 c3us8A_ not modelled 90.3 15 PDB header:oxidoreductase Chain: A: PDB Molecule:isocitrate dehydrogenase [nadp]; PDBTitle: crystal structure of an isocitrate dehydrogenase from sinorhizobium2 meliloti 1021 40 d2jgra1 not modelled 90.1 19 Fold:NAD kinase/diacylglycerol kinase-like Superfamily:NAD kinase/diacylglycerol kinase-like Family:Diacylglycerol kinase-like 41 c1zorB_ not modelled 86.9 13 PDB header:oxidoreductase Chain: B: PDB Molecule:isocitrate dehydrogenase; PDBTitle: isocitrate dehydrogenase from the hyperthermophile thermotoga maritima 42 d2p1ra1 not modelled 86.6 18 Fold:NAD kinase/diacylglycerol kinase-like Superfamily:NAD kinase/diacylglycerol kinase-like Family:Diacylglycerol kinase-like 43 c2pjuD_ not modelled 85.0 13 PDB header:transcription Chain: D: PDB Molecule:propionate catabolism operon regulatory protein; PDBTitle: crystal structure of propionate catabolism operon2 regulatory protein prpr 44 c2bonB_ not modelled 81.4 18 PDB header:transferase Chain: B: PDB Molecule:lipid kinase; PDBTitle: structure of an escherichia coli lipid kinase (yegs) 45 c2ohoA_ not modelled 81.0 23 PDB header:isomerase Chain: A: PDB Molecule:glutamate racemase; PDBTitle: structural basis for glutamate racemase inhibitor 46 c2uxqB_ not modelled 80.8 21 PDB header:oxidoreductase Chain: B: PDB Molecule:isocitrate dehydrogenase native; PDBTitle: isocitrate dehydrogenase from the psychrophilic bacterium2 desulfotalea psychrophila: biochemical properties and3 crystal structure analysis 47 d2bona1 not modelled 77.0 18 Fold:NAD kinase/diacylglycerol kinase-like Superfamily:NAD kinase/diacylglycerol kinase-like Family:Diacylglycerol kinase-like 48 c2qzsA_ not modelled 75.3 14 PDB header:transferase Chain: A: PDB Molecule:glycogen synthase; PDBTitle: crystal structure of wild-type e.coli gs in complex with adp2 and glucose(wtgsb) 49 d2pjua1 not modelled 66.0 13 Fold:Chelatase-like Superfamily:PrpR receptor domain-like Family:PrpR receptor domain-like 50 d2qv7a1 not modelled 64.3 24 Fold:NAD kinase/diacylglycerol kinase-like Superfamily:NAD kinase/diacylglycerol kinase-like Family:Diacylglycerol kinase-like 51 c2qv7A_ not modelled 64.3 24 PDB header:transferase Chain: A: PDB Molecule:diacylglycerol kinase dgkb; PDBTitle: crystal structure of diacylglycerol kinase dgkb in complex with adp2 and mg 52 c1zuwA_ not modelled 62.0 15 PDB header:isomerase Chain: A: PDB Molecule:glutamate racemase 1; PDBTitle: crystal structure of b.subtilis glutamate racemase (race) with d-glu 53 c2gn9B_ not modelled 58.3 20 PDB header:lyase Chain: B: PDB Molecule:udp-glcnac c6 dehydratase; PDBTitle: crystal structure of udp-glcnac inverting 4,6-dehydratase in complex2 with nadp and udp-glc 54 d1yo6a1 not modelled 58.0 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 55 c2wdfA_ not modelled 50.4 23 PDB header:hydrolase Chain: A: PDB Molecule:sulfur oxidation protein soxb; PDBTitle: termus thermophilus sulfate thiohydrolase soxb 56 c3cg4A_ not modelled 50.2 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:response regulator receiver domain protein (chey-like); PDBTitle: crystal structure of response regulator receiver domain protein (chey-2 like) from methanospirillum hungatei jf-1 57 c3toxG_ not modelled 48.1 20 PDB header:oxidoreductase Chain: G: PDB Molecule:short chain dehydrogenase; PDBTitle: crystal structure of a short chain dehydrogenase in complex with2 nad(p) from sinorhizobium meliloti 1021 58 c3uk7B_ not modelled 46.3 22 PDB header:transferase Chain: B: PDB Molecule:class i glutamine amidotransferase-like domain-containing PDBTitle: crystal structure of arabidopsis thaliana dj-1d 59 c2uvdE_ not modelled 43.3 18 PDB header:oxidoreductase Chain: E: PDB Molecule:3-oxoacyl-(acyl-carrier-protein) reductase; PDBTitle: the crystal structure of a 3-oxoacyl-(acyl carrier protein)2 reductase from bacillus anthracis (ba3989) 60 c3n74A_ not modelled 41.4 15 PDB header:oxidoreductase Chain: A: PDB Molecule:3-ketoacyl-(acyl-carrier-protein) reductase; PDBTitle: crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase from2 brucella melitensis 61 c2x0dA_ not modelled 40.1 15 PDB header:transferase Chain: A: PDB Molecule:wsaf; PDBTitle: apo structure of wsaf 62 d1z6za1 not modelled 38.2 25 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 63 c2q6vA_ not modelled 38.0 16 PDB header:transferase Chain: A: PDB Molecule:glucuronosyltransferase gumk; PDBTitle: crystal structure of gumk in complex with udp 64 d1nffa_ not modelled 37.3 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 65 c3f5sA_ not modelled 37.2 15 PDB header:oxidoreductase Chain: A: PDB Molecule:dehydrogenase; PDBTitle: crystal structure of putatitve short chain dehydrogenase from shigella2 flexneri 2a str. 301 66 c3ak4C_ not modelled 37.2 15 PDB header:oxidoreductase Chain: C: PDB Molecule:nadh-dependent quinuclidinone reductase; PDBTitle: crystal structure of nadh-dependent quinuclidinone reductase from2 agrobacterium tumefaciens 67 d1wyza1 not modelled 36.7 8 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 68 c2q5cA_ not modelled 36.4 14 PDB header:transcription Chain: A: PDB Molecule:ntrc family transcriptional regulator; PDBTitle: crystal structure of ntrc family transcriptional regulator from2 clostridium acetobutylicum 69 d2f7wa1 not modelled 35.0 13 Fold:Molybdenum cofactor biosynthesis proteins Superfamily:Molybdenum cofactor biosynthesis proteins Family:MogA-like 70 d2b4ro1 not modelled 34.7 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 71 d1y5ma1 not modelled 34.4 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 72 d1rkba_ not modelled 34.1 11 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nucleotide and nucleoside kinases 73 c1zggA_ not modelled 33.9 18 PDB header:hydrolase Chain: A: PDB Molecule:putative low molecular weight protein-tyrosine- PDBTitle: solution structure of a low molecular weight protein2 tyrosine phosphatase from bacillus subtilis 74 c3c3mA_ not modelled 33.5 9 PDB header:signaling protein Chain: A: PDB Molecule:response regulator receiver protein; PDBTitle: crystal structure of the n-terminal domain of response regulator2 receiver protein from methanoculleus marisnigri jr1 75 d1iy8a_ not modelled 33.3 26 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 76 d1j9ja_ not modelled 33.0 12 Fold:SurE-like Superfamily:SurE-like Family:SurE-like 77 c3h7aC_ not modelled 32.6 13 PDB header:oxidoreductase Chain: C: PDB Molecule:short chain dehydrogenase; PDBTitle: crystal structure of short-chain dehydrogenase from2 rhodopseudomonas palustris 78 d1fmca_ not modelled 32.2 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 79 d1gado1 not modelled 32.2 18 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 80 d1uc8a1 not modelled 31.5 16 Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:Lysine biosynthesis enzyme LysX, N-terminal domain 81 c3t6oA_ not modelled 31.0 13 PDB header:transport protein Chain: A: PDB Molecule:sulfate transporter/antisigma-factor antagonist stas; PDBTitle: the structure of an anti-sigma-factor antagonist (stas) domain protein2 from planctomyces limnophilus. 82 d1yioa2 not modelled 30.9 12 Fold:Flavodoxin-like Superfamily:CheY-like Family:CheY-related 83 c2wmyH_ not modelled 30.2 19 PDB header:hydrolase Chain: H: PDB Molecule:putative acid phosphatase wzb; PDBTitle: crystal structure of the tyrosine phosphatase wzb from2 escherichia coli k30 in complex with sulphate. 84 d1u8fo1 not modelled 29.9 16 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 85 c3lf2B_ not modelled 29.7 28 PDB header:oxidoreductase Chain: B: PDB Molecule:short chain oxidoreductase q9hya2; PDBTitle: nadph bound structure of the short chain oxidoreductase q9hya2 from2 pseudomonas aeruginosa pao1 containing an atypical catalytic center 86 d1xu9a_ not modelled 29.3 26 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 87 c3ivdA_ not modelled 29.0 19 PDB header:hydrolase Chain: A: PDB Molecule:nucleotidase; PDBTitle: putative 5'-nucleotidase (c4898) from escherichia coli in2 complex with uridine 88 c3r1iB_ not modelled 28.9 24 PDB header:oxidoreductase Chain: B: PDB Molecule:short-chain type dehydrogenase/reductase; PDBTitle: crystal structure of a short-chain type dehydrogenase/reductase from2 mycobacterium marinum 89 c2fekA_ not modelled 28.1 18 PDB header:hydrolase Chain: A: PDB Molecule:low molecular weight protein-tyrosine- PDBTitle: structure of a protein tyrosine phosphatase 90 d1hdca_ not modelled 27.5 18 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 91 c3ftpD_ not modelled 27.5 22 PDB header:oxidoreductase Chain: D: PDB Molecule:3-oxoacyl-[acyl-carrier protein] reductase; PDBTitle: crystal structure of 3-ketoacyl-(acyl-carrier-protein)2 reductase from burkholderia pseudomallei at 2.05 a3 resolution 92 d1ys7a2 not modelled 27.3 11 Fold:Flavodoxin-like Superfamily:CheY-like Family:CheY-related 93 d1jlja_ not modelled 27.2 10 Fold:Molybdenum cofactor biosynthesis proteins Superfamily:Molybdenum cofactor biosynthesis proteins Family:MogA-like 94 d3gpdg1 not modelled 27.1 15 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 95 c3i1jB_ not modelled 27.1 17 PDB header:oxidoreductase Chain: B: PDB Molecule:oxidoreductase, short chain PDBTitle: structure of a putative short chain dehydrogenase from2 pseudomonas syringae 96 c3jyfB_ not modelled 27.0 21 PDB header:hydrolase Chain: B: PDB Molecule:2',3'-cyclic nucleotide 2'-phosphodiesterase/3'- PDBTitle: the crystal structure of a 2,3-cyclic nucleotide 2-2 phosphodiesterase/3-nucleotidase bifunctional periplasmic precursor3 protein from klebsiella pneumoniae subsp. pneumoniae mgh 78578 97 c3oy2A_ not modelled 26.6 15 PDB header:viral protein,transferase Chain: A: PDB Molecule:glycosyltransferase b736l; PDBTitle: crystal structure of a putative glycosyltransferase from paramecium2 bursaria chlorella virus ny2a 98 c3rkrC_ not modelled 26.6 24 PDB header:oxidoreductase Chain: C: PDB Molecule:short chain oxidoreductase; PDBTitle: crystal structure of a metagenomic short-chain oxidoreductase (sdr) in2 complex with nadp 99 d1y7pa1 not modelled 26.2 27 Fold:Flavodoxin-like Superfamily:CheY-like Family:AF1403 C-terminal domain-like 100 d2gdza1 not modelled 26.1 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 101 d2d1ya1 not modelled 25.9 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 102 c2r60A_ not modelled 25.6 17 PDB header:transferase Chain: A: PDB Molecule:glycosyl transferase, group 1; PDBTitle: structure of apo sucrose phosphate synthase (sps) of2 halothermothrix orenii 103 c3nhzA_ not modelled 25.2 13 PDB header:dna binding protein Chain: A: PDB Molecule:two component system transcriptional regulator mtra; PDBTitle: structure of n-terminal domain of mtra 104 c2wdzD_ not modelled 24.9 19 PDB header:oxidoreductase Chain: D: PDB Molecule:short-chain dehydrogenase/reductase; PDBTitle: crystal structure of the short chain dehydrogenase2 galactitol-dehydrogenase (gatdh) of rhodobacter3 sphaeroides in complex with nad+ and 1,2-pentandiol 105 d1uh5a_ not modelled 24.7 9 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 106 c2is8A_ not modelled 24.2 15 PDB header:structural protein Chain: A: PDB Molecule:molybdopterin biosynthesis enzyme, moab; PDBTitle: crystal structure of the molybdopterin biosynthesis enzyme moab2 (ttha0341) from thermus theromophilus hb8 107 d1wmaa1 not modelled 24.1 27 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 108 c2v4oB_ not modelled 24.1 9 PDB header:hydrolase Chain: B: PDB Molecule:multifunctional protein sur e; PDBTitle: crystal structure of salmonella typhimurium sure at 2.752 angstrom resolution in monoclinic form 109 d1th8b_ not modelled 23.9 23 Fold:SpoIIaa-like Superfamily:SpoIIaa-like Family:Anti-sigma factor antagonist SpoIIaa 110 c2p91A_ not modelled 23.5 17 PDB header:oxidoreductase Chain: A: PDB Molecule:enoyl-[acyl-carrier-protein] reductase [nadh]; PDBTitle: crystal structure of enoyl-[acyl-carrier-protein] reductase (nadh)2 from aquifex aeolicus vf5 111 c1y7pB_ not modelled 23.4 27 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein af1403; PDBTitle: 1.9 a crystal structure of a protein of unknown function2 af1403 from archaeoglobus fulgidus, probable metabolic3 regulator 112 d2nlya1 not modelled 23.3 22 Fold:7-stranded beta/alpha barrel Superfamily:Glycoside hydrolase/deacetylase Family:Divergent polysaccharide deacetylase 113 c3zu0A_ not modelled 23.3 20 PDB header:hydrolase Chain: A: PDB Molecule:nad nucleotidase; PDBTitle: structure of haemophilus influenzae nad nucleotidase (nadn) 114 d1yb1a_ not modelled 23.2 28 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 115 d1q7ba_ not modelled 23.0 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 116 d1xq1a_ not modelled 22.8 26 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 117 d1pr9a_ not modelled 22.8 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases 118 c2zatC_ not modelled 21.5 24 PDB header:oxidoreductase Chain: C: PDB Molecule:dehydrogenase/reductase sdr family member 4; PDBTitle: crystal structure of a mammalian reductase 119 c3f43A_ not modelled 21.2 8 PDB header:transcription Chain: A: PDB Molecule:putative anti-sigma factor antagonist tm1081; PDBTitle: crystal structure of a putative anti-sigma factor antagonist (tm1081)2 from thermotoga maritima at 1.59 a resolution 120 d1yxma1 not modelled 21.2 26 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0