BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (329 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q3IFD2 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   405   e-111
UniRef50_Q87ST5 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   403   e-111
UniRef50_C7R7U0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   382   e-105
UniRef50_A1U6F9 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   375   e-102
UniRef50_C6P2R8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   367   e-100
UniRef50_Q8D3I2 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   355   9e-97
UniRef50_A5CWR9 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   308   2e-82
UniRef50_Q475Q2 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   306   5e-82
UniRef50_A5WDW5 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   297   3e-79
UniRef50_A6GTC8 Pyridoxal phosphate biosynthetic protein PdxA n=...   287   3e-76
UniRef50_Q4JN67 Predicted 4-hydroxythreonine-4-phosphate dehydro...   263   5e-69
UniRef50_Q87AJ1 4-hydroxythreonine-4-phosphate dehydrogenase n=7...   260   6e-68
UniRef50_UPI0000E87C06 4-hydroxythreonine-4-phosphate dehydrogen...   259   7e-68
UniRef50_UPI0000D5482C 4-hydroxythreonine-4-phosphate dehydrogen...   241   3e-62
UniRef50_A7HYG3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   236   9e-61
UniRef50_Q0EWH4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   230   5e-59
UniRef50_A6DS02 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   227   3e-58
UniRef50_A1FAW6 Pyridoxal phosphate biosynthetic protein PdxA (F...   223   9e-57
UniRef50_Q1GI38 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   221   3e-56
UniRef50_B2IDU5 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   218   2e-55
UniRef50_B8FEI1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   217   4e-55
UniRef50_Q1NMK1 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   215   2e-54
UniRef50_Q11UL9 Pyridoxal phosphate biosynthesis protein n=3 Tax...   214   4e-54
UniRef50_C0QBU5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   212   1e-53
UniRef50_Q215S3 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   209   1e-52
UniRef50_A0LIN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   209   1e-52
UniRef50_B0KBL6 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   209   2e-52
UniRef50_A7IJ81 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   208   2e-52
UniRef50_C1SJH6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   207   3e-52
UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic prot...   206   1e-51
UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   205   1e-51
UniRef50_C8QYR8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   205   2e-51
UniRef50_C6XKP9 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   204   4e-51
UniRef50_A0LA33 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   204   5e-51
UniRef50_B1L710 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   202   2e-50
UniRef50_B2V9E6 4-hydroxythreonine-4-phosphate dehydrogenase n=5...   201   2e-50
UniRef50_Q0FGB3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   201   3e-50
UniRef50_C6X2C9 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   198   2e-49
UniRef50_A3ERM0 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   198   2e-49
UniRef50_P58718 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   198   2e-49
UniRef50_Q8CUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   196   8e-49
UniRef50_Q2S3U3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   196   9e-49
UniRef50_C6VZ75 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   195   2e-48
UniRef50_Q89NF3 4-hydroxythreonine-4-phosphate dehydrogenase 1 n...   195   2e-48
UniRef50_A6FY83 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   194   3e-48
UniRef50_D1UTB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   193   7e-48
UniRef50_A1VC56 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   192   9e-48
UniRef50_C4X874 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   192   2e-47
UniRef50_C5T2H3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   192   2e-47
UniRef50_UPI0000D53337 pyridoxal phosphate biosynthesis protein ...   191   3e-47
UniRef50_C5ELY2 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   190   5e-47
UniRef50_D2QDF7 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   190   5e-47
UniRef50_B4S6L0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   190   7e-47
UniRef50_A6TJU5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   189   9e-47
UniRef50_C9LG48 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   189   1e-46
UniRef50_Q89ZK3 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   188   2e-46
UniRef50_P58711 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   188   3e-46
UniRef50_Q5NMX3 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   187   3e-46
UniRef50_B1ZQS3 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   186   8e-46
UniRef50_Q30Z16 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   186   8e-46
UniRef50_C6XHX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   186   1e-45
UniRef50_B7UKV9 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   185   2e-45
UniRef50_A0JTQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=9...   185   2e-45
UniRef50_B5JFI3 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   185   2e-45
UniRef50_Q02C14 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   184   4e-45
UniRef50_B2U6L2 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   184   4e-45
UniRef50_B1B883 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   184   5e-45
UniRef50_B6BUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   183   6e-45
UniRef50_D2R6V9 4-hydroxythreonine-4-phosphate dehydrogenase n=7...   182   1e-44
UniRef50_Q6AB12 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   180   5e-44
UniRef50_A6H263 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   179   9e-44
UniRef50_C0A8L4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   179   1e-43
UniRef50_Q2N8X0 4-hydroxythreonine-4-phosphate dehydrogenase n=5...   179   1e-43
UniRef50_A0NP49 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   178   2e-43
UniRef50_D0LQB4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   178   3e-43
UniRef50_Q7UMZ2 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   177   4e-43
UniRef50_C1A9L0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   177   5e-43
UniRef50_B5YL57 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   177   6e-43
UniRef50_B9XEU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   177   7e-43
UniRef50_C5SNX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   176   8e-43
UniRef50_B8IXF1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   176   9e-43
UniRef50_C7M3J3 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   176   1e-42
UniRef50_C6E7W5 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   176   1e-42
UniRef50_B4U950 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   175   2e-42
UniRef50_C7PP38 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   175   2e-42
UniRef50_C6C747 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   173   6e-42
UniRef50_C0CYU8 Putative uncharacterized protein n=1 Tax=Clostri...   173   8e-42
UniRef50_A1TTF8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   172   2e-41
UniRef50_B4D0B0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   172   2e-41
UniRef50_B3DY74 Pyridoxal phosphate biosynthesis protein n=1 Tax...   171   2e-41
UniRef50_A7HIW4 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   171   4e-41
UniRef50_A8ME07 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   171   4e-41
UniRef50_A6L8G2 4-hydroxythreonine-4-phosphate dehydrogenase n=7...   171   4e-41
UniRef50_Q1DF36 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   170   5e-41
UniRef50_B2KET4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   170   5e-41
UniRef50_Q92X16 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   170   7e-41
UniRef50_Q8DHB4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   170   7e-41
UniRef50_D0J9Z1 4-hydroxythreonin-phosphate dehydrogenase n=1 Ta...   167   5e-40
UniRef50_Q2CJB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   166   7e-40
UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   166   9e-40
UniRef50_A9GKN1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   164   4e-39
UniRef50_Q7MAP7 PDXA HOMOLOG n=1 Tax=Wolinella succinogenes RepI...   164   5e-39
UniRef50_D2TK32 Putative uncharacterized protein n=1 Tax=Citroba...   161   2e-38
UniRef50_C2EXJ2 Putative uncharacterized protein (Fragment) n=4 ...   160   5e-38
UniRef50_B1GZF5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   160   8e-38
UniRef50_C3JBU1 4-hydroxythreonine-4-phosphate dehydrogenase n=5...   160   8e-38
UniRef50_A6C4H6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   158   3e-37
UniRef50_B1IGV8 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   157   4e-37
UniRef50_UPI00019F1502 4-hydroxythreonine-4-phosphate dehydrogen...   157   5e-37
UniRef50_Q0C095 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   154   3e-36
UniRef50_Q4FMQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   154   3e-36
UniRef50_B2UL26 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   154   3e-36
UniRef50_A9LFJ9 Pyridoxal phosphate biosynthetic protein (Fragme...   154   6e-36
UniRef50_Q2KXH9 4-hydroxythreonine-4-phosphate dehydrogenase n=9...   153   7e-36
UniRef50_Q04UJ6 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   152   1e-35
UniRef50_Q9CKG8 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   151   3e-35
UniRef50_C5CPN5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   150   5e-35
UniRef50_C3XMM1 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   149   1e-34
UniRef50_Q30S58 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   149   1e-34
UniRef50_Q17ZN0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   149   1e-34
UniRef50_Q3V7R5 Pyridoxal phosphate biosynthetic protein n=1 Tax...   148   3e-34
UniRef50_Q390F1 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   148   3e-34
UniRef50_A5GHP5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   147   3e-34
UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   147   4e-34
UniRef50_B8FR92 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   146   9e-34
UniRef50_A8S524 Putative uncharacterized protein n=1 Tax=Clostri...   146   9e-34
UniRef50_D0RQA4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   146   1e-33
UniRef50_Q92TP3 4-hydroxythreonine-4-phosphate dehydrogenase 3 n...   145   2e-33
UniRef50_Q31DF6 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   142   2e-32
UniRef50_Q0RWE6 Terephthalate dihydrodiol dehydrogenase n=2 Tax=...   140   4e-32
UniRef50_A1RD08 Pyridoxal phosphate biosynthetic protein n=2 Tax...   134   4e-30
UniRef50_D0E8J8 Pyridoxal phosphate biosynthesis protein n=1 Tax...   130   5e-29
UniRef50_B0SEJ8 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   130   6e-29
UniRef50_Q5HTM4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   124   6e-27
UniRef50_O85987 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   122   1e-26
UniRef50_A7T2T3 Predicted protein (Fragment) n=1 Tax=Nematostell...   120   9e-26
UniRef50_Q4HSN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   117   4e-25
UniRef50_P94285 PdxA homolog (Fragment) n=1 Tax=Burkholderia cep...   117   6e-25
UniRef50_C9PYW4 Pyridoxal phosphate biosynthetic protein PdxA n=...   115   1e-24
UniRef50_UPI00019786BC 4-hydroxythreonine-4-phosphate dehydrogen...   115   2e-24
UniRef50_D0J448 Terephthalate dihydrodiol dehydrogenase n=5 Tax=...   112   3e-23
UniRef50_UPI0000D53588 4-hydroxythreonine-4-phosphate dehydrogen...   103   1e-20
UniRef50_Q47824 4-hydroxythreonine-4-phosphate dehydrogenase (Fr...    99   2e-19
UniRef50_C6SCG8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...    85   3e-15
UniRef50_C3XJ32 4-hydroxythreonine-4-phosphate dehydrogenase n=1...    80   1e-13
UniRef50_D0RPG9 Pyridoxal phosphate biosynthetic protein PdxA n=...    74   8e-12
UniRef50_UPI00016999D5 4-hydroxythreonine-4-phosphate dehydrogen...    67   8e-10
UniRef50_A7C3I0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...    59   2e-07
UniRef50_Q7X217 Putative 4-hydroxthreonine-4-phosphate dehydroge...    51   5e-05
UniRef50_A6GMT1 Hemolysin activation/secretion protein-like prot...    44   0.006
UniRef50_UPI000190527A 4-hydroxythreonine-4-phosphate dehydrogen...    41   0.075

>UniRef50_Q3IFD2 4-hydroxythreonine-4-phosphate dehydrogenase n=68
           Tax=Proteobacteria RepID=PDXA_PSEHT
          Length = 330

 Score =  405 bits (1041), Expect = e-111,   Method: Compositional matrix adjust.
 Identities = 203/321 (63%), Positives = 244/321 (76%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           T R+ ITPGEPAGIGPDL+++LAQ+ W  +LV  ADA +L  RA  LGL + L  +  ++
Sbjct: 2   TLRIAITPGEPAGIGPDLLLKLAQQTWDAQLVAIADANMLKQRAKHLGLSIKLIEFDQHA 61

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A P  AG+L L  V +  PV  G L   NG YV++TL  A +  ++G FAA++TGPVHK
Sbjct: 62  AATPAPAGSLYLHQVDVAEPVELGVLNDANGQYVLDTLRIASEKNMDGTFAAVVTGPVHK 121

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
           G+IN AGI F+GHTE+F ++S    VVMMLAT+ LRVAL TTH+PL  ++ AIT   L +
Sbjct: 122 GIINKAGISFSGHTEYFAQQSNTADVVMMLATQGLRVALVTTHIPLAYVSRAITEDRLIK 181

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
           V +IL+HDL+TKFGI +PRILVCGLNPHAGE GH+G EEIDTIIP L  L  QGM L GP
Sbjct: 182 VASILNHDLQTKFGIEKPRILVCGLNPHAGEDGHLGREEIDTIIPTLEILNNQGMNLIGP 241

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           LPADTLFQ KYL+ ADAVLAMYHDQGLPVLKY+GFG  VNITLGLPFIRTSVDHGTAL+L
Sbjct: 242 LPADTLFQDKYLNEADAVLAMYHDQGLPVLKYKGFGNSVNITLGLPFIRTSVDHGTALDL 301

Query: 304 AGRGKADVGSFITALNLAIKM 324
           AG+G ADVGSF  A+  AIK+
Sbjct: 302 AGKGTADVGSFELAIREAIKL 322


>UniRef50_Q87ST5 4-hydroxythreonine-4-phosphate dehydrogenase n=34 Tax=Bacteria
           RepID=PDXA_VIBPA
          Length = 332

 Score =  403 bits (1035), Expect = e-111,   Method: Compositional matrix adjust.
 Identities = 199/326 (61%), Positives = 244/326 (74%), Gaps = 1/326 (0%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           +R+V+T GEPAGIGPDLV+ L++ +W  ++VVCAD  +L  RA MLG+ + L  Y+P   
Sbjct: 7   RRIVVTAGEPAGIGPDLVLALSKEDWAHQIVVCADKNMLLERAKMLGIDVQLFDYNPEEA 66

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
            + Q AGTL +  V +     AGQL   NGHYV++TL RA  GC+N EF A++TGPVHKG
Sbjct: 67  PKAQKAGTLIVDHVEIAENAIAGQLNEANGHYVLKTLERAALGCMNDEFDAIVTGPVHKG 126

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
           VIN AG+ F+GHTEFF E+S    VVMMLATE LRVAL TTH+PL  ++ A+T   L ++
Sbjct: 127 VINRAGVAFSGHTEFFAEKSNTPLVVMMLATEGLRVALVTTHIPLAYVSKAVTEERLEKI 186

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL-RAQGMKLNGP 243
           I ILH DL  KF IAEP I VCGLNPHAGE G +G EEI+TI P L ++ + +G+KL GP
Sbjct: 187 IDILHKDLVEKFAIAEPNIYVCGLNPHAGEDGCLGREEIETITPTLEKIQKEKGIKLIGP 246

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           LPADT+F  KYL++ADAVL MYHDQ LPVLKY+GFGR VNITLGLPFIRTSVDHGTALEL
Sbjct: 247 LPADTIFNEKYLNDADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTALEL 306

Query: 304 AGRGKADVGSFITALNLAIKMIVNTQ 329
           AG G+AD GSF TAL  AI+++   Q
Sbjct: 307 AGTGQADTGSFRTALTHAIELVEKKQ 332


>UniRef50_C7R7U0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Kangiella
           koreensis DSM 16069 RepID=C7R7U0_KANKD
          Length = 332

 Score =  382 bits (982), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 186/330 (56%), Positives = 243/330 (73%), Gaps = 1/330 (0%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M++  R++IT GEPAGIGP+++V+LAQ     +L+ CA  TLL + A  L LPL L  ++
Sbjct: 1   MIQPARILITAGEPAGIGPEIIVKLAQEPCSDQLIACASPTLLKDTAQQLHLPLELSVFN 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            N  A     G L ++PV L +PV AG+L   N  YV++TL  A    +NG   A++TGP
Sbjct: 61  TNEEALAHRIGHLWIVPVELESPVIAGKLNQTNAAYVIKTLDTAHQLAINGAVNAILTGP 120

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           VHKG+IN +G+ FTGHTEFF ++S A KVVMMLATE LRVALATTHLPL++++ A+TP L
Sbjct: 121 VHKGIINQSGLAFTGHTEFFADKSNAHKVVMMLATEGLRVALATTHLPLKEVSGAVTPQL 180

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ-GMK 239
           L EVI IL H+L++KF +  P++LVCGLNPHAGE GH+G EE+DTIIP L ++R Q   +
Sbjct: 181 LQEVIEILIHELQSKFSLKRPKVLVCGLNPHAGEDGHLGREEVDTIIPTLEKMRTQFDAE 240

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           L GP+PADT FQPK+L   D VLAMYHDQGLP LKY+GFG+ +N+TLGLP+IRTSVDHGT
Sbjct: 241 LIGPIPADTAFQPKWLTQVDTVLAMYHDQGLPTLKYKGFGKAINLTLGLPYIRTSVDHGT 300

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNTQ 329
            L++AG+G AD+GS   AL    ++I N +
Sbjct: 301 GLDIAGQGLADIGSMHYALQFTQQLINNRK 330


>UniRef50_A1U6F9 4-hydroxythreonine-4-phosphate dehydrogenase n=125
           Tax=Proteobacteria RepID=PDXA_MARAV
          Length = 336

 Score =  375 bits (962), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 192/318 (60%), Positives = 234/318 (73%), Gaps = 1/318 (0%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           + +T GEPAGIGP+L +QLA       LVV A   LL +RA+ LGL + L  + P   A 
Sbjct: 7   LALTAGEPAGIGPELCLQLATGSRDAGLVVIASGELLRDRASQLGLQIELHDWQPGVAAA 66

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
            + AG L++  V       AG+L   N  YV++TL  A  GCLNG+F  ++T PVHKGVI
Sbjct: 67  TR-AGHLSVRHVEGCGSTVAGRLDKANSQYVLDTLTIAARGCLNGDFDGMVTAPVHKGVI 125

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIA 186
           N+AGI F+GHTEF +E    ++VVMMLATEELRVAL TTHLPL+D++ AITP  L +V  
Sbjct: 126 NEAGIVFSGHTEFLQELCGVERVVMMLATEELRVALVTTHLPLKDVSAAITPDRLTQVTR 185

Query: 187 ILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPA 246
           IL+ DL+  FGI +PRILV GLNPHAGEGGH+G EEI+ I P L +LRA+G++L GPLPA
Sbjct: 186 ILNADLKAFFGIDQPRILVAGLNPHAGEGGHLGREEIEVIEPTLEQLRAEGIQLTGPLPA 245

Query: 247 DTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGR 306
           DTLF P +LDNADAVLAMYHDQGLPVLK+QGFGR VNITLGLP +RTSVDHGTAL+LAG 
Sbjct: 246 DTLFTPHWLDNADAVLAMYHDQGLPVLKFQGFGRAVNITLGLPIVRTSVDHGTALDLAGT 305

Query: 307 GKADVGSFITALNLAIKM 324
           GKAD GS  TA+ +  +M
Sbjct: 306 GKADAGSLHTAIRVGEQM 323


>UniRef50_C6P2R8 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Sideroxydans
           lithotrophicus ES-1 RepID=C6P2R8_9PROT
          Length = 358

 Score =  367 bits (942), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 198/356 (55%), Positives = 244/356 (68%), Gaps = 38/356 (10%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           +VIT GEPAGIGPDL +QLA  + P  LVV AD +LL +RAA+LG  + L  Y+ + P +
Sbjct: 7   LVITAGEPAGIGPDLCLQLAGHDQP--LVVIADKSLLLHRAALLGTGVRLHDYAADRPLE 64

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
               G L++L V L  P  AG+L   N  YV+ETL RA  GCL+GEF+ ++T PVHKG+I
Sbjct: 65  ---NGKLSVLHVPLHRPAQAGKLDSANSPYVLETLRRAVQGCLSGEFSGMVTAPVHKGII 121

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMML-----------------------------ATEE 157
           NDAGIPFTGHTEF  E++    VVMML                             A+ E
Sbjct: 122 NDAGIPFTGHTEFLAEQTHTPLVVMMLVGRGMRGRHGDAQHSVREPAQRITDTALAASSE 181

Query: 158 ----LRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAG 213
               +RVALATTHLPLR++ADAIT  LL  V+ I+  DL+ +FGIA PRILV GLNPHAG
Sbjct: 182 NEFVMRVALATTHLPLREVADAITAPLLENVLRIMQRDLQRRFGIARPRILVAGLNPHAG 241

Query: 214 EGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVL 273
           E GH+G EEID +IPVL++LRA+G  ++ PLPADTLF    L + DAVL MYHDQGLPVL
Sbjct: 242 ESGHLGREEIDVMIPVLDKLRAEGFNVSPPLPADTLFAAHRLRDCDAVLTMYHDQGLPVL 301

Query: 274 KYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           K+  FG GVNITLGLP IRTSVDHGTALELAG GKA+VGS + A+ +A++M+ N +
Sbjct: 302 KHASFGGGVNITLGLPIIRTSVDHGTALELAGTGKAEVGSLLEAIKVAMEMVRNER 357


>UniRef50_Q8D3I2 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Gammaproteobacteria RepID=PDXA_WIGBR
          Length = 332

 Score =  355 bits (912), Expect = 9e-97,   Method: Compositional matrix adjust.
 Identities = 168/324 (51%), Positives = 222/324 (68%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M K  R++ITPGEPAGIG DLVV ++Q+ W  ELV+C D  +L  RA   G+ L L  Y+
Sbjct: 1   MNKISRIIITPGEPAGIGFDLVVLISQKIWRSELVICCDPDILVKRAKDHGIKLKLHFYN 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            N   + +  G LT++P+ + + VT G L + N +YV+ TL RAC GC+N EF+AL+TGP
Sbjct: 61  KNLSPKVREKGELTIIPIKVNSNVTRGILNINNSYYVINTLTRACLGCINKEFSALVTGP 120

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           VHKG+I D+GI F GHTEF    S  K  VMML    LR+ALAT H+P++DI+  I   L
Sbjct: 121 VHKGIIKDSGIKFIGHTEFLAGFSLCKNPVMMLMYNSLRIALATNHIPIKDISKCINFNL 180

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           + + + ++ + LR  F I  P I VCGLNPHAGE GH+GTEEI+ I P ++ L+    K+
Sbjct: 181 IRKKLIVIFNSLRNIFKINNPCIYVCGLNPHAGESGHIGTEEINIIQPAISSLKYLPCKI 240

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+ AD++FQ KYL +ADA+LAMYHDQGLP++KY GF + VNITLGLPFIRTSVDHGTA
Sbjct: 241 IGPISADSIFQQKYLKDADAILAMYHDQGLPMIKYIGFRKSVNITLGLPFIRTSVDHGTA 300

Query: 301 LELAGRGKADVGSFITALNLAIKM 324
           L +    +    S   A++LAI +
Sbjct: 301 LNIKNLNEISSKSMEKAISLAIDI 324


>UniRef50_A5CWR9 4-hydroxythreonine-4-phosphate dehydrogenase n=8
           Tax=Gammaproteobacteria RepID=A5CWR9_VESOH
          Length = 332

 Score =  308 bits (788), Expect = 2e-82,   Method: Compositional matrix adjust.
 Identities = 162/324 (50%), Positives = 206/324 (63%), Gaps = 12/324 (3%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           +  T GEP+GIGPDL V  AQ +    L++  D  +L NRA  L L + +         +
Sbjct: 4   IAFTVGEPSGIGPDLAVIYAQIKSNKNLLLFTDPDVLLNRAKQLNLNIKI--------IE 55

Query: 67  PQTAGT---LTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            + AG+   L + P+ +   V  G L  +N  YV+ TL  A + CLN    AL+TGP+HK
Sbjct: 56  AEQAGSNYELAVYPIKVNTHVECGILNKDNAQYVLNTLDCATEYCLNSRCDALVTGPIHK 115

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
           G+IN AGI FTGHTE+    S   K VMMLAT  LRVALATTH+PL D+   IT   L +
Sbjct: 116 GIINQAGINFTGHTEYLANLSNIDKTVMMLATNGLRVALATTHMPLSDVPQNITTQSLKK 175

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            I+I+H  L    G+  P+I+VCGLNPHAGE G++G EEI+ I P++ EL +QG  L G 
Sbjct: 176 TISIIHQFLLNN-GVNTPKIVVCGLNPHAGENGYLGMEEIEIINPLIKELNSQGYNLVGS 234

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           +PADT F P  L   D VL+MYHDQGLPVLK  GF + VNITLGLPFIRTSVDHG+AL L
Sbjct: 235 IPADTAFTPNSLTGVDCVLSMYHDQGLPVLKTLGFKKAVNITLGLPFIRTSVDHGSALNL 294

Query: 304 AGRGKADVGSFITALNLAIKMIVN 327
           AG G   +GS  TA+N A  +++N
Sbjct: 295 AGTGNISLGSLNTAINYAQMLVIN 318


>UniRef50_Q475Q2 4-hydroxythreonine-4-phosphate dehydrogenase n=261
           Tax=Proteobacteria RepID=PDXA_RALEJ
          Length = 347

 Score =  306 bits (785), Expect = 5e-82,   Method: Compositional matrix adjust.
 Identities = 175/334 (52%), Positives = 212/334 (63%), Gaps = 24/334 (7%)

Query: 7   VVITPGEPAGIGPDLVV----QLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           + I+ GEPAGIGPD+ +    QLA +       V  DA LL +RAA LG+         +
Sbjct: 7   LAISTGEPAGIGPDITIGALLQLAGQNGHARYHVLGDAHLLASRAAALGVA--------H 58

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLN-----GEFAALI 117
           +  +    G + +  V L      G+L   NG YV+  L  A  GC         FAA++
Sbjct: 59  AWERRIAEGEVVIHHVPLAVACEPGRLDARNGPYVLSMLDAAIAGCRTHAGAPARFAAMV 118

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE-------LRVALATTHLPLR 170
           T PV K  INDAG+PFTGHTE+  E +   +VVMMLA  +       LRVALATTHLPLR
Sbjct: 119 TAPVQKSTINDAGVPFTGHTEYLAEAAGVPRVVMMLAGPQPAHANAMLRVALATTHLPLR 178

Query: 171 DIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVL 230
            +ADA+T  LL E ++I+  DLR  FGIA PRILV GLNPHAGE GHMG EEI+ I P L
Sbjct: 179 AVADAVTVPLLLETLSIIDADLRRWFGIARPRILVTGLNPHAGESGHMGREEINVIEPAL 238

Query: 231 NELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPF 290
            + R  G+   GP PADTLFQP++L +AD VLAMYHDQGL  LKY  FG GVNITLGLPF
Sbjct: 239 AQARDAGIDARGPYPADTLFQPRHLRDADCVLAMYHDQGLAPLKYGTFGHGVNITLGLPF 298

Query: 291 IRTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           IRTSVDHGTAL+LAG G+A+ GS I A+  A+ M
Sbjct: 299 IRTSVDHGTALDLAGSGQAEHGSMIEAIRSAVTM 332


>UniRef50_A5WDW5 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Gammaproteobacteria RepID=A5WDW5_PSYWF
          Length = 374

 Score =  297 bits (761), Expect = 3e-79,   Method: Compositional matrix adjust.
 Identities = 174/356 (48%), Positives = 220/356 (61%), Gaps = 29/356 (8%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQR----EWPVELVVCADATLLTNR--------AAML 50
            +  +V+T GEPAGIG D+++QLA +    E    L+V AD   L  R         + L
Sbjct: 18  SSASLVVTTGEPAGIGMDILLQLAMQQKLGELSYPLIVLADEAALQQRFELIYGSGVSKL 77

Query: 51  GLPLTLRPYSPNSPAQ--PQTAGT----LTLLPVALRAPVTAGQLAVENGHYVVETLARA 104
             PL  R  S N   Q   QT G       LL V    PV AGQL V N   VV+ L  A
Sbjct: 78  SGPLWQRIESVNDLQQISGQTKGNALPQFYLLHVGCAEPVVAGQLNVNNAAMVVQQLQIA 137

Query: 105 CDGCLNGEFAALITGPVHKGVINDAGIP------FTGHTEFFEERSQAKKVVMMLATEEL 158
                +G  +A++TGP+ K V+ DAGI       FTGHTEFF ++S  +KVVMMLA   +
Sbjct: 138 HQWAASGAASAIVTGPLQKSVLIDAGITLEDGGMFTGHTEFFMQKSGCQKVVMMLANSAM 197

Query: 159 RVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHM 218
           +VAL T H+PLR +ADAIT   + + + I+ +DLR KFG+  P+ILVCGLNPHAGE GH+
Sbjct: 198 KVALVTIHMPLRQVADAITADNVRQTVRIVLNDLRQKFGLPNPKILVCGLNPHAGEDGHL 257

Query: 219 GTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGF 278
           GTEEID I PVL E + QG  ++  +PADTLF  ++L + DAV+AMYHDQGLPVLK  GF
Sbjct: 258 GTEEIDIINPVLREFQQQGANISLAMPADTLFTTRHLQDCDAVIAMYHDQGLPVLKSHGF 317

Query: 279 GRGVNITLGLPFIRTSVDHGTALELAGRG-KADV----GSFITALNLAIKMIVNTQ 329
           G  VN+TLGLP+IRTSVDHGTAL+LAG    +DV     S   AL +A  M+ + Q
Sbjct: 318 GDTVNLTLGLPYIRTSVDHGTALDLAGNSATSDVQPSSSSLWQALIMAEAMVHSQQ 373


>UniRef50_A6GTC8 Pyridoxal phosphate biosynthetic protein PdxA n=1 Tax=Limnobacter
           sp. MED105 RepID=A6GTC8_9BURK
          Length = 340

 Score =  287 bits (735), Expect = 3e-76,   Method: Compositional matrix adjust.
 Identities = 161/325 (49%), Positives = 202/325 (62%), Gaps = 8/325 (2%)

Query: 7   VVITPGEPAGIGPDLVVQLAQ----REWPVELVVCADATLLTNRAAMLGL-PLTLRPYSP 61
           ++IT GEPAGIGP+L   LA+    +     LV+  DA LL  RA   G+ P   R  S 
Sbjct: 9   ILITSGEPAGIGPELCALLAETSQAKRLNRSLVILGDADLLETRAKNAGIEPKWQRINSL 68

Query: 62  NSPA--QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
              A  +P+  G   LL   L  P   GQ    N  YV+  L  ACD C NG  AA++T 
Sbjct: 69  RDIATGEPEAPGYF-LLDHPLSTPCITGQPNPANAPYVLGLLNMACDACQNGTAAAMVTA 127

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P+ K  I+     F GHTE+  ER     VVMML   +++VALATTH+PL  + +AIT +
Sbjct: 128 PIQKSAISPHWPGFMGHTEYLAERCGQGDVVMMLIGGQMKVALATTHIPLAKVPEAITRS 187

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            L   + I+ HDL   + + +PRILV GLNPHAGE G +G EEIDTI P +  L+A+G  
Sbjct: 188 SLTRTLEIMLHDLSLYWSLPKPRILVTGLNPHAGESGDLGREEIDTITPTIKALQARGHD 247

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           + GP PADTLFQPKYL N+DAVLAM+HDQGLPVLK+  FG+GVN++LGLP +RTSVDHGT
Sbjct: 248 VQGPFPADTLFQPKYLQNSDAVLAMFHDQGLPVLKHASFGQGVNVSLGLPIVRTSVDHGT 307

Query: 300 ALELAGRGKADVGSFITALNLAIKM 324
           AL+LAG    D GS   A+  A  M
Sbjct: 308 ALDLAGTRNMDAGSLNEAIECAHHM 332


>UniRef50_Q4JN67 Predicted 4-hydroxythreonine-4-phosphate dehydrogenase
           (4-(Phosphohydroxy)-L-threonine dehydrogenase) n=1
           Tax=uncultured bacterium BAC13K9BAC RepID=Q4JN67_9BACT
          Length = 326

 Score =  263 bits (673), Expect = 5e-69,   Method: Compositional matrix adjust.
 Identities = 128/316 (40%), Positives = 188/316 (59%), Gaps = 1/316 (0%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           ++ IT G+P GIGPD+ V +A++      ++  D  LL + +  L   + +      + A
Sbjct: 4   KIAITVGDPGGIGPDICVLMAEKYLKKYHIIITDPQLLIDSSKKLNKKVFINILKNINDA 63

Query: 66  QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
                  + +LP+ L      G +   N  +V+  +  A  GCLN  F +++TGP+ K +
Sbjct: 64  PKSGKRLINVLPIKLNKKNKPGHMNPINAPFVINAIETAAKGCLNHNFQSMVTGPISKSI 123

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
           +N  G   +GHTE   +  ++K + MML  ++L+V L T H+PL  ++  IT   +   I
Sbjct: 124 LNRGGFKISGHTELLAKICKSKSI-MMLMNDKLKVTLQTIHVPLNKVSKQITEKNIIGKI 182

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
            I++HDL  KFG+  P+IL+CGLNPHAGE G +G EEI+ I P +  L+  G+ ++GP+P
Sbjct: 183 KIINHDLINKFGLKNPKILICGLNPHAGEEGILGNEEINIIKPAILSLKKLGINVDGPVP 242

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
           ADT F  KY++  D +  MYHDQGLPV+KY  F +  N+TLGLP IR SVDHGTA EL G
Sbjct: 243 ADTAFISKYINEYDVIHTMYHDQGLPVIKYDNFSKTTNVTLGLPIIRVSVDHGTATELVG 302

Query: 306 RGKADVGSFITALNLA 321
            G  D+ SFI AL +A
Sbjct: 303 TGNVDISSFIQALKVA 318


>UniRef50_Q87AJ1 4-hydroxythreonine-4-phosphate dehydrogenase n=7 Tax=Xylella
           fastidiosa RepID=PDXA_XYLFT
          Length = 330

 Score =  260 bits (664), Expect = 6e-68,   Method: Compositional matrix adjust.
 Identities = 158/319 (49%), Positives = 194/319 (60%), Gaps = 6/319 (1%)

Query: 7   VVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           + + PGEPAG+GP+L V+L Q+      LV  AD   L   AA L     L        A
Sbjct: 6   LALVPGEPAGVGPELCVRLVQQPRQDCRLVAFADPATLQAAAAAL----DLPLRLLPPEA 61

Query: 66  QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
            P+  G L +       P   G     N   V+  L  A   C++G    ++TGPVHK V
Sbjct: 62  LPERPGDLPIQAHCHVHPTRFGHPDPANAPAVIAALCEAASHCVHGVLHGIVTGPVHKAV 121

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
           IN +GI +TG TE    +++   VVMMLA   LRVAL TTHLPLRD+ DAIT ALL   +
Sbjct: 122 INQSGIHYTGTTELLAAQAECD-VVMMLANPHLRVALVTTHLPLRDVPDAITAALLERCL 180

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
            I++  +   FGIA PRI V GLNPHAGE G++G EE+D +IPVL  LRA+GM L GPL 
Sbjct: 181 RIVNTAMCGDFGIATPRIAVLGLNPHAGEEGYLGREELDVVIPVLQRLRAEGMVLLGPLS 240

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
           ADT F P  L   DAV+AMYHDQGLPVLK+ GF + VNITLGLP+ R +VDHGTAL+LAG
Sbjct: 241 ADTAFLPTKLIGYDAVVAMYHDQGLPVLKHSGFEQAVNITLGLPYPRVAVDHGTALDLAG 300

Query: 306 RGKADVGSFITALNLAIKM 324
           RG AD  S   A  L  ++
Sbjct: 301 RGVADPSSLFAATALCARL 319


>UniRef50_UPI0000E87C06 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Methylophilales bacterium HTCC2181
           RepID=UPI0000E87C06
          Length = 324

 Score =  259 bits (663), Expect = 7e-68,   Method: Compositional matrix adjust.
 Identities = 136/320 (42%), Positives = 193/320 (60%), Gaps = 5/320 (1%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           +++I  G+P+GIG DL+V LA++ +   + + A+   L  RA + G  L  +     + +
Sbjct: 7   KIIINCGDPSGIGLDLIVFLAEKPFNASITILANKESLVQRAGLHGKKLAFQ----ENVS 62

Query: 66  QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
             +  G L +  +     V  G     N    ++ +  A   C+   + AL+T P+ K +
Sbjct: 63  LHKGDGRLYVKNIHYENDVIPGLPNKHNSKAQMQMIDHAVKECMAMNYDALVTLPISKEI 122

Query: 126 INDAGIPFTGHTEFFEERSQAK-KVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
           ++D+   FTGHTE+  + S  K + VMML   +LRVALATTH+PL D+   IT   L ++
Sbjct: 123 LSDSNNKFTGHTEYIAKLSNIKNQEVMMLVHNKLRVALATTHIPLSDVPKTITREKLEKI 182

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL 244
           I  LH+DL+TKF +  PRI V GLNPHAGE G  G EE+  +IP++N+L  QG  L GP+
Sbjct: 183 ILTLHNDLKTKFKVLSPRITVTGLNPHAGENGEFGNEELTVLIPIINKLNEQGCNLVGPI 242

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELA 304
           PADT F P ++   DA LAM+HDQGL   K   FG+GVNITLGLPFIRTSVDHGTA ++ 
Sbjct: 243 PADTAFTPGHIKKTDAFLAMFHDQGLAPFKALSFGKGVNITLGLPFIRTSVDHGTAFDIV 302

Query: 305 GRGKADVGSFITALNLAIKM 324
           G  + D  SF  A+  AI++
Sbjct: 303 GSKEIDPSSFYEAIFTAIEL 322


>UniRef50_UPI0000D5482C 4-hydroxythreonine-4-phosphate
           dehydrogenase,(4-(phosphohydroxy)-L-threonine n=1
           Tax=Psychroflexus torquis ATCC 700755
           RepID=UPI0000D5482C
          Length = 284

 Score =  241 bits (614), Expect = 3e-62,   Method: Compositional matrix adjust.
 Identities = 122/284 (42%), Positives = 172/284 (60%)

Query: 42  LLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETL 101
           L   R A L   + +         +    G L ++  +  +    G+L   N  YV++ L
Sbjct: 1   LFVARTATLKKKVKILELDSLDQVKKNIKGHLQIIKTSKCSNTKPGKLYKSNAQYVLDNL 60

Query: 102 ARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVA 161
             +    +  +  AL+TGP+ K  I      FTGHTEF ++ +++K V+MMLA+++LRVA
Sbjct: 61  NYSIKQTMLNKRTALVTGPLSKENIISIDKSFTGHTEFIKKVTKSKDVLMMLASDQLRVA 120

Query: 162 LATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTE 221
           L+TTH+PL++++  IT  L+   + IL+ DL++KF I +P I V GLNPHAGE G +G E
Sbjct: 121 LSTTHIPLKNVSKKITKELIINKVKILNEDLQSKFNIHKPSIKVLGLNPHAGENGKIGRE 180

Query: 222 EIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRG 281
           E D I P + ELR + + ++ P+ ADT F  K L   DA L MYHDQ LPVLK   FGR 
Sbjct: 181 EQDHIKPAIRELRKKKINVSMPVSADTAFSNKSLKETDAFLGMYHDQVLPVLKTLSFGRS 240

Query: 282 VNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
           +NITLG+P IRTSVDHG AL++AG  K+D  S I A+  A K+I
Sbjct: 241 INITLGIPIIRTSVDHGVALDIAGTNKSDPSSLILAIKTAKKLI 284


>UniRef50_A7HYG3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Alphaproteobacteria RepID=A7HYG3_PARL1
          Length = 340

 Score =  236 bits (602), Expect = 9e-61,   Method: Compositional matrix adjust.
 Identities = 143/316 (45%), Positives = 181/316 (57%), Gaps = 7/316 (2%)

Query: 12  GEPAGIGPDLVVQL----AQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQP 67
           GEPAGIGP++ ++     A++  P+   V  D  L    +  LG    +R  S  S A  
Sbjct: 16  GEPAGIGPEITLKAWAARAEKSLPI-FFVAGDPALYRTASERLGAGAAIREISDPSEAAE 74

Query: 68  QTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVIN 127
              G L +LPV L    T GQL+  N   V+ ++  ACD    G+ + L+T P+HK V+ 
Sbjct: 75  VFPGALPVLPVPLHEAATPGQLSGANAAAVLASIDTACDAVTAGKASGLVTNPIHKRVLY 134

Query: 128 DAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAI 187
           DAG    GHTE+  ER+   K VMML+   LRV   T HL L+D    +T + + E   I
Sbjct: 135 DAGFHVPGHTEYLAERTGGAKPVMMLSCPGLRVVPVTVHLSLKDAVAVLTTSEIVEHGLI 194

Query: 188 LHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ--GMKLNGPLP 245
           L   L   FGI++PRI +  LNPHAGE GH+G EEID I P    L     G +++GPLP
Sbjct: 195 LSRSLTADFGISKPRIAIAALNPHAGEEGHLGREEIDIIAPAAKLLAEALPGAEISGPLP 254

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
           ADTLF        DAVL MYHDQ L  LK   F RGVNITLGLP +RTS DHGTAL++AG
Sbjct: 255 ADTLFHAAARARHDAVLCMYHDQALIPLKTIDFARGVNITLGLPIVRTSPDHGTALDIAG 314

Query: 306 RGKADVGSFITALNLA 321
           RG AD  S I A+ +A
Sbjct: 315 RGVADPESLIEAILVA 330


>UniRef50_Q0EWH4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Mariprofundus
           ferrooxydans PV-1 RepID=Q0EWH4_9PROT
          Length = 340

 Score =  230 bits (586), Expect = 5e-59,   Method: Compositional matrix adjust.
 Identities = 132/332 (39%), Positives = 185/332 (55%), Gaps = 14/332 (4%)

Query: 7   VVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           ++IT GEPAGIG D +++  Q   +   + ++ A A  L  RA ++G+ + ++  +    
Sbjct: 4   LLITAGEPAGIGTDCILRAWQHTPQLFKQCIIAAPALWLRERADLIGIDVIIKESADLQQ 63

Query: 65  AQPQTAGTLTLL-PVALRA---PVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
                   L    P+A      PVT GQ +      V+  +  A   CL+   AALITGP
Sbjct: 64  IDCSDTSRLHCWNPLAANVAVDPVTPGQPSPGTARAVITCIESAALACLDNRAAALITGP 123

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKV--------VMMLATEELRVALATTHLPLRDI 172
           + K V+ ++G  F GHTEF    S++           VMMLA+++LRVAL TTH+ + D+
Sbjct: 124 IEKAVLRESGFTFPGHTEFLAHLSRSNASLATDHMDHVMMLASDQLRVALLTTHIAISDV 183

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
             +++     + + I+ HDLR +F I +P I +CGLNPHAGE GH G EEID + P    
Sbjct: 184 PASLSIDGTLDGLRIVEHDLRKRFAIEKPHIGLCGLNPHAGEQGHFGREEIDILTPAAEL 243

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
            + +G+ + GPLPADTLF        DA++  YHDQ L  LK   FG  VNITLGLPFIR
Sbjct: 244 AKKRGIHVTGPLPADTLFSASQRSRFDAIVCCYHDQALIPLKALSFGDAVNITLGLPFIR 303

Query: 293 TSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           TSVDHGTAL+  G       S + A+ +A  M
Sbjct: 304 TSVDHGTALDRVGSQSVSYTSMVAAIRMASTM 335


>UniRef50_A6DS02 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Lentisphaerae
           RepID=A6DS02_9BACT
          Length = 326

 Score =  227 bits (579), Expect = 3e-58,   Method: Compositional matrix adjust.
 Identities = 122/331 (36%), Positives = 186/331 (56%), Gaps = 9/331 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQ----LAQREWPVELVVCADATLLTNRAAMLGLPLTL 56
           M+K + +++T G+PAG+GP++ V+    LA  ++P   V+  DA +L+    +      L
Sbjct: 1   MMKNKAMILTSGDPAGVGPEVAVKAFAKLANEKFP--FVIAGDAYVLSEAIELYAPEFKL 58

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
           +PY P      +         +A  +     + + + G    + +  A    +  +++A+
Sbjct: 59  KPYIPGE--WEEGVVYYDDFGLAFESSYEKCKASAQCGQLSYDLIVEATHAVIAKQYSAI 116

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
           +T PV+K  +N AGI F+GHTE   E  +  +  MM + + LR   AT H+ L+++  A+
Sbjct: 117 VTAPVNKESVNLAGITFSGHTELIAELCECPEFNMMQSADRLRCVFATCHIALKEVPKAL 176

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           T   + +   +LH     + G+ +P++   GLNPHAGE G+MG EEI+T+IP L  LR++
Sbjct: 177 TVDKILQAGRLLHQACLAE-GLVKPKLSAAGLNPHAGENGYMGREEIETVIPALEILRSE 235

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G+ + GP P DTLF P   +  +  L MYHDQG    K   F RGVN TLGLP IRTSVD
Sbjct: 236 GIDIEGPFPPDTLFVPAIRERFEGFLCMYHDQGHIPFKMLAFDRGVNSTLGLPIIRTSVD 295

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMIVN 327
           HGTA ++A + KAD+GS   AL LA K   N
Sbjct: 296 HGTAFDIAWQNKADIGSLENALKLAWKRTGN 326


>UniRef50_A1FAW6 Pyridoxal phosphate biosynthetic protein PdxA (Fragment) n=1
           Tax=Vibrio cholerae 2740-80 RepID=A1FAW6_VIBCH
          Length = 197

 Score =  223 bits (567), Expect = 9e-57,   Method: Compositional matrix adjust.
 Identities = 109/195 (55%), Positives = 140/195 (71%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           + ++R+++T GEPAGIGPDLV+ L+ ++WP +LVVCAD  LL  RA  LG+ + L  Y  
Sbjct: 1   MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQR 60

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           ++P Q Q AGTL +  + L  PV AGQL   NGHYV++TL RA  GC+NGEF A++TGPV
Sbjct: 61  DNPVQAQQAGTLLVEHIPLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPV 120

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           HKGVIN AG+ F+GHTEFF E+S+   VVMMLATE LR AL TTHLPL ++  AIT   L
Sbjct: 121 HKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERL 180

Query: 182 HEVIAILHHDLRTKF 196
            +++ ILH DL  K 
Sbjct: 181 EQIVHILHKDLVEKL 195


>UniRef50_Q1GI38 4-hydroxythreonine-4-phosphate dehydrogenase n=30
           Tax=Proteobacteria RepID=PDXA_SILST
          Length = 326

 Score =  221 bits (562), Expect = 3e-56,   Method: Compositional matrix adjust.
 Identities = 135/326 (41%), Positives = 181/326 (55%), Gaps = 7/326 (2%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           Q + ++ GEPAGIGP++ V      W      C    +   R      P   +P S  + 
Sbjct: 6   QVIALSCGEPAGIGPEIAVA----AWDQLRADCPFVWIGDPRHLPSSHPW--QPVSAPAE 59

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK- 123
           A   +A  L + P+      T G+   +N   V++++    +   +G+ AAL T P+HK 
Sbjct: 60  ALQVSADALPVWPLEFAGNTTKGEADPQNASGVIQSIKTGVELVTSGKAAALCTAPIHKK 119

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
            +I+ AG  + GHTEF         VVMMLA+  LRV  AT H+PL  + + +TP  L  
Sbjct: 120 ALIDGAGFAYPGHTEFLAALGGVDHVVMMLASAALRVVPATIHIPLSAVPEVLTPDHLRR 179

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
           VI +    LR +FG+  PRI V GLNPHAGEGG MG EE D I  ++ E++ +G +L GP
Sbjct: 180 VITLTDRGLRDQFGLTAPRIAVTGLNPHAGEGGAMGQEEGDWIEALIREMQTEGYRLTGP 239

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
            PADTLF        DA +AMYHDQ L  +K   F +GVN+TLGLPFIRTS DHGTA ++
Sbjct: 240 HPADTLFHAAARARYDAAIAMYHDQALIPIKTLDFDKGVNVTLGLPFIRTSPDHGTAFDI 299

Query: 304 AGRGKADVGSFITALNLAIKMIVNTQ 329
           AG+G A+  S I AL LA  M    Q
Sbjct: 300 AGKGLANPSSLIEALRLAQTMAKTRQ 325


>UniRef50_B2IDU5 4-hydroxythreonine-4-phosphate dehydrogenase n=29 Tax=cellular
           organisms RepID=PDXA_BEII9
          Length = 337

 Score =  218 bits (555), Expect = 2e-55,   Method: Compositional matrix adjust.
 Identities = 131/333 (39%), Positives = 183/333 (54%), Gaps = 26/333 (7%)

Query: 9   ITPGEPAGIGPDLVVQLA-----QREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           +T G+P+GIGP+++ ++      +R W    +V  D  ++ +  A LG+ + +R  +   
Sbjct: 10  VTMGDPSGIGPEIIAKMYLRRPDKRNW----IVVGDPLVMEHAIANLGVAVQIRRIATVE 65

Query: 64  PAQPQ-------TAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
            A  +        + +L  LP   R    +GQ A +    +V  +  A  G + G    +
Sbjct: 66  EAGCEDGVLNVLASSSLATLPAVGRVSAVSGQAAYDA---IVTAIGLARQGTIRG----I 118

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRD-IADA 175
           +T P+HK  +  AGI + GHTE   E+  A+ V MMLA +E+R  L T H  L D I  A
Sbjct: 119 VTAPIHKEALAAAGIHYPGHTEILAEQGGAQHVAMMLANDEIRTVLVTIHCSLADAIRKA 178

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
             PA +  +   L H+     GI +PRI V GLNPHAGEGG  G EEI  I P +   RA
Sbjct: 179 DFPAQMQAIR--LAHEGARALGIVQPRIAVAGLNPHAGEGGLFGDEEIRIITPAIAAARA 236

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G+   GP P DT+F    L   D V+A YHDQGL  +K+ G  +GVNITLGLPF+RTS 
Sbjct: 237 EGIDATGPWPGDTVFMQARLGKFDVVVAQYHDQGLIPVKFMGLEKGVNITLGLPFVRTSP 296

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           DHGTA ++AGRG AD  S  TA + A ++ V T
Sbjct: 297 DHGTAFDIAGRGIADSSSLETAFDYATRLKVPT 329


>UniRef50_B8FEI1 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Desulfatibacillum alkenivorans AK-01
           RepID=PDXA_DESAA
          Length = 333

 Score =  217 bits (553), Expect = 4e-55,   Method: Compositional matrix adjust.
 Identities = 128/322 (39%), Positives = 178/322 (55%), Gaps = 14/322 (4%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPY-SPNSP 64
           IT G+P G+GP+++V+  + +   ++   +V  D  ++    +++   L  RP  SP   
Sbjct: 9   ITMGDPVGVGPEIIVKTLKNKDIYKICRPLVIGDLKVMEQAESLIRSGLDFRPAGSPEDA 68

Query: 65  AQPQTAGTLTLLPV-----ALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
           A     G + +LPV     A  AP T      + G  +V+ +  A D   +    A+ TG
Sbjct: 69  AYEY--GRVDILPVSDLDPARLAPKTP---CAKTGEAMVKYITTAVDYARDNRIQAVTTG 123

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P+ K  ++ AG  F GHTE   +R+   K VMMLA ++LRV L T H+ + +I   +T  
Sbjct: 124 PIQKAAVHAAGYTFAGHTELLAQRTGTSKYVMMLAGDKLRVVLVTIHMAVSEIPAHVTRE 183

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
              E + +    L+ +FGI +P++ V  LNPHAGE G  GTEE D IIP +   +   + 
Sbjct: 184 KFIETVEVTGQALKERFGIPQPKMAVAALNPHAGEEGAFGTEERDVIIPAMEHFKGSDIA 243

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           L+GP PADTLF        DAV+ MYHDQGL   K   F  GVN TLGLP IRTSVDHGT
Sbjct: 244 LDGPWPADTLFYHAQQGKWDAVVCMYHDQGLIPFKMIHFHDGVNTTLGLPIIRTSVDHGT 303

Query: 300 ALELAGRGKADVGSFITALNLA 321
           A +LAG GKAD GS   A+ +A
Sbjct: 304 AYDLAGTGKADHGSMEAAIRMA 325


>UniRef50_Q1NMK1 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Proteobacteria
           RepID=Q1NMK1_9DELT
          Length = 340

 Score =  215 bits (547), Expect = 2e-54,   Method: Compositional matrix adjust.
 Identities = 135/328 (41%), Positives = 179/328 (54%), Gaps = 13/328 (3%)

Query: 9   ITPGEPAGIGPDLVV----QLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           IT G PAGIGP++++    +LA       LVV  D  +L + A  LG  + LR + P   
Sbjct: 12  ITMGCPAGIGPEIILRFWSELATAGQRRSLVVLGDPGVLAHNARQLGFKVPLRVWHPQEA 71

Query: 65  AQPQTAGTLTLLPVA-LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
             P     L +LPV+ L AP   G+   E+G  +   +  AC   + GE  A++T P+ K
Sbjct: 72  PNP---AALNILPVSELSAPPPWGRPTPESGRAMGRYIVEACRLAMGGELTAMVTCPIGK 128

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
            ++N  G  + GHTE      ++ +  MM+A   LRV LAT H PL  +  A+ PA LH 
Sbjct: 129 EMLNAGGYHYPGHTEMLAALCKSPEYAMMMAGHRLRVVLATIHCPLTAVPAALEPAKLHH 188

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTI----IPVLNELRAQGMK 239
           ++ +    LR  F I  PR+ V GLNPHAGEGG  G EE   I         EL  +G +
Sbjct: 189 LLRLTVAALRRDFAIPAPRLAVAGLNPHAGEGGMFGHEEKTVIAPAVAAAAAELGGKG-E 247

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           L GP P DT+F      + DAV+AMYHDQGL   K   F  GVN+TLGLP +RTSVDHGT
Sbjct: 248 LVGPRPPDTVFHQAAAGHFDAVVAMYHDQGLIPFKLLHFSDGVNVTLGLPVVRTSVDHGT 307

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVN 327
           A ++AGRG AD  S   A  LA ++  +
Sbjct: 308 AYDIAGRGLADPASLAAAFQLATEIAAH 335


>UniRef50_Q11UL9 Pyridoxal phosphate biosynthesis protein n=3 Tax=Sphingobacteriales
           RepID=Q11UL9_CYTH3
          Length = 341

 Score =  214 bits (545), Expect = 4e-54,   Method: Compositional matrix adjust.
 Identities = 127/323 (39%), Positives = 177/323 (54%), Gaps = 3/323 (0%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           IT G+  G+GP+L+++       +++   V+ A+  LL     +LGL   L  +S  S  
Sbjct: 14  ITLGDFNGVGPELILKTFSDSRILKVCIPVIYANYKLLARYKKILGLYEELNFHSIRSIQ 73

Query: 66  QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
           + Q      L+       VT GQ   E+G     +L +A    L G   A++T P+ K  
Sbjct: 74  EVQPKKINLLVCWEDDFEVTPGQPTNESGKAAFLSLEKAVSDALAGSIQAIVTAPIDKKN 133

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
           I   G  F GHTE+  ER   K  +M++ +  ++VALAT H+ +  I   +T   L   I
Sbjct: 134 IQQEGFTFAGHTEYLAERCGVKDNLMVMVSPTMKVALATAHVSVAQITANLTRERLLTKI 193

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
            +L++ L+  FGI +P+I V GLNPHAGE G MGTEE   I PV+ EL+ +G+ + GP P
Sbjct: 194 NLLYNSLKKDFGILKPKIAVLGLNPHAGENGMMGTEEQTLISPVIKELKDKGILIFGPFP 253

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
           AD  F   +    D VLAMYHDQGL   K   F  GVN T GLPFIRTS DHGTA +LAG
Sbjct: 254 ADGFFGQHHYTKFDGVLAMYHDQGLAPFKALCFDEGVNFTGGLPFIRTSPDHGTAYDLAG 313

Query: 306 RGKADVGSFITALNLAIKMIVNT 328
           +      SF +A+ LA  ++ N+
Sbjct: 314 KNLVAEESFRSAIYLACDLVKNS 336


>UniRef50_C0QBU5 4-hydroxythreonine-4-phosphate dehydrogenase n=10
           Tax=Deltaproteobacteria RepID=PDXA_DESAH
          Length = 340

 Score =  212 bits (540), Expect = 1e-53,   Method: Compositional matrix adjust.
 Identities = 125/320 (39%), Positives = 183/320 (57%), Gaps = 10/320 (3%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVELVVCADATL----LTNRAAMLGLPLTLRPYSPNSP 64
           IT G+P GIGP+++V  +  + P    VC    L    +  RA  L     +  ++ ++P
Sbjct: 10  ITMGDPVGIGPEIIV--SALDDPFVYTVCRPLVLGDEGVMERAIDLK-SARMDVHTTDTP 66

Query: 65  AQPQTA-GTLTLLPVAL--RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           A  +   GT+ ++P++    A + AG      G  +++ +    D  ++G+  A+ T P+
Sbjct: 67  AGGKYCHGTMDIVPLSRLDAATLLAGHPTPGTGKAMIDYITTGVDLAMDGKIQAIATCPI 126

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
            K  +  AG  F GHTE   +R+   +V MM+A + LRV L T H+PL +++  +  A +
Sbjct: 127 TKTAMKLAGSKFHGHTELIADRTHTPRVAMMMAGDRLRVVLVTIHIPLCEVSARLNQAEI 186

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
              I++    L+TKFGI EPRI V GLNPH GE G  G+EE++ I P + + R++G+ ++
Sbjct: 187 LATISLTSETLKTKFGIPEPRIAVAGLNPHGGEDGMFGSEELEIIAPAVEQARSKGITVS 246

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP P DTLF        DAV+ MYHDQGL   K   F  GVN TLGLP IRTSVDHGTA 
Sbjct: 247 GPFPPDTLFFNAANHKFDAVVCMYHDQGLIPFKMIHFSDGVNTTLGLPIIRTSVDHGTAY 306

Query: 302 ELAGRGKADVGSFITALNLA 321
           ++A RG AD  S I A+ +A
Sbjct: 307 DIAWRGTADPSSLIAAIKMA 326


>UniRef50_Q215S3 4-hydroxythreonine-4-phosphate dehydrogenase n=10
           Tax=Alphaproteobacteria RepID=Q215S3_RHOPB
          Length = 339

 Score =  209 bits (531), Expect = 1e-52,   Method: Compositional matrix adjust.
 Identities = 136/336 (40%), Positives = 176/336 (52%), Gaps = 12/336 (3%)

Query: 2   VKTQRVVITPGEPAGIGPD--LVVQLAQREWPV-ELVVCADATLLTNRAAMLGLPLTLRP 58
           V  + + +T GEPAGIGPD  L   L +   P+    +  D   L  RAA LGL +   P
Sbjct: 4   VSNKPLALTLGEPAGIGPDVALAAWLGRGTSPIPAFYLLGDRAFLQARAATLGLNV---P 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTA--GQLAVENGHYVVETLARACDGCLNGEFAAL 116
           ++   P Q        L  V    PVTA  G+    +    +  + +A    + G  AA+
Sbjct: 61  FAEVRPDQAAATFADALPVVGTGHPVTAMPGRPDGSSAAAAIGAIRQAVQDVIAGRAAAV 120

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAK----KVVMMLATEELRVALATTHLPLRDI 172
           +T P+ K V+  AG    GHTEF  E ++ +    + VMML +E L V   T HLPLRD 
Sbjct: 121 VTNPIAKSVLYQAGFKHPGHTEFLAELARGEGAPPQPVMMLWSEALAVVPVTIHLPLRDA 180

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
              +T  L+     I+   LR    IA PR+ V GLNPHAGE G +G E+   I P +  
Sbjct: 181 IAQLTTGLIVSTARIVASALRRHMRIAAPRLAVSGLNPHAGEDGGLGREDQSIIAPAVEI 240

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
           LR  G+   GPLPADT+F        D  L MYHDQ L  +K   F R VN+TLGLPF+R
Sbjct: 241 LRRDGIDARGPLPADTMFHEAARKTYDCALCMYHDQALIPVKTLAFDRAVNVTLGLPFVR 300

Query: 293 TSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           TS DHGTA ++AG G+AD  S I AL LA +M   T
Sbjct: 301 TSPDHGTAFDIAGSGRADPSSLIEALRLAARMATPT 336


>UniRef50_A0LIN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Syntrophobacter fumaroxidans MPOB RepID=PDXA_SYNFM
          Length = 345

 Score =  209 bits (531), Expect = 1e-52,   Method: Compositional matrix adjust.
 Identities = 136/337 (40%), Positives = 182/337 (54%), Gaps = 23/337 (6%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLP---LTLRPY 59
           R+ +T G+P G+GPD++ Q        E    +V  D + L    A+ G     L LR  
Sbjct: 7   RIALTMGDPCGVGPDVIAQALASPTLFECCTPIVVGDPSALQRSMALSGASKKVLVLR-- 64

Query: 60  SPNSPAQ-PQTAGTLTLLPVALRAPVTAGQLAVENGH-------YVVETLARACDGCLNG 111
               PA+ P   G+     + L APV      +E+G         VV  +  A    L G
Sbjct: 65  ---EPAELPDDPGSDR---IPLIAPVELSGRDIEHGRPTAATCGAVVRYIESAVAFALAG 118

Query: 112 EFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRD 171
           +   + TGP++K  +++ G  F GHTEF +  + +++VVMMLA   LRV+LAT H  L D
Sbjct: 119 QVRGVCTGPINKARMHEHGFDFPGHTEFLQALTGSRRVVMMLAGPRLRVSLATIHEALAD 178

Query: 172 IADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLN 231
           +   +   +L EVI I    L   FG+  PR+ V GLNPHAGE G  G EEI+ + P + 
Sbjct: 179 VPALLNVEMLREVIRITAEALIRDFGLQAPRLAVAGLNPHAGEEGRFGREEIEILRPAIE 238

Query: 232 ELRAQG-MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPF 290
            LR  G   + GP PADTLFQ  +    DAV+AMYHDQGL  +K   F   VN++LGLP 
Sbjct: 239 SLRPPGRCTVTGPYPADTLFQRAHAGEFDAVVAMYHDQGLVPIKLVHFYDAVNVSLGLPI 298

Query: 291 IRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           +RTSVDHGTA +LAG G+A  GS   A+ LA  M  N
Sbjct: 299 VRTSVDHGTAYDLAGTGRAHPGSLTAAVQLAALMAHN 335


>UniRef50_B0KBL6 4-hydroxythreonine-4-phosphate dehydrogenase n=3
           Tax=Thermoanaerobacter RepID=B0KBL6_THEP3
          Length = 331

 Score =  209 bits (531), Expect = 2e-52,   Method: Compositional matrix adjust.
 Identities = 129/332 (38%), Positives = 182/332 (54%), Gaps = 25/332 (7%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPY------- 59
           V IT G+PAG+GP++ ++ A         V A+ +    R  +LG  L LR Y       
Sbjct: 5   VAITMGDPAGVGPEISLKAA---------VSAEVSSFA-RPLILGSGLVLRYYANLLKIS 54

Query: 60  ----SPNSPAQPQTA--GTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEF 113
               S +SPA+ Q      +++  ++L A    G+++   G    E L       L GE 
Sbjct: 55  VPLRSIDSPAEYQDGFVNYISVNNLSL-ADFEIGKVSPLCGRAAYEYLEAGIRMALRGEA 113

Query: 114 AALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIA 173
           +A+ T P++K  ++ AG+ F GHTE   + +  K   MML    LRV   +TH+ LR   
Sbjct: 114 SAIATAPLNKEALHRAGLEFAGHTEILAKLTGTKDYAMMLVAGNLRVMHVSTHVALRGAC 173

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL 233
           D +    +++++  L        G+ +PRI V GLNPHAGEGG  G EEI  I P + + 
Sbjct: 174 DMVKKERVYKIVT-LAATAAASLGVRDPRIAVAGLNPHAGEGGLFGDEEIYEIAPAVEKA 232

Query: 234 RAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
           R QG+ + GPLP DT+F        D V+AMYHDQG   +K  GF RGVN+T+GLP IRT
Sbjct: 233 REQGLSVYGPLPPDTVFLKASRGEYDVVVAMYHDQGHIAVKMAGFERGVNVTVGLPIIRT 292

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIKMI 325
           SVDHGTA ++AGRG AD  S + A+ LA +M+
Sbjct: 293 SVDHGTAFDIAGRGIADERSMVEAVKLAAEMV 324


>UniRef50_A7IJ81 4-hydroxythreonine-4-phosphate dehydrogenase n=127
           Tax=Proteobacteria RepID=PDXA_XANP2
          Length = 350

 Score =  208 bits (530), Expect = 2e-52,   Method: Compositional matrix adjust.
 Identities = 132/324 (40%), Positives = 175/324 (54%), Gaps = 11/324 (3%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVV-QLAQRE---WPVELVVCADATLLTNRAAMLGLPLTL 56
           MV    +V++ G+PAGIGPD+ +   AQR     P   +V  D   L  R   LGL + L
Sbjct: 1   MVAPAPLVLSLGDPAGIGPDITLTAWAQRRELGLPA-FLVAGDPEALKARVRQLGLTVPL 59

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
               P   A    A  L ++P    +    G     +   VV +L  A      G  AAL
Sbjct: 60  AETGPEDAAG-HFAEALPVMPAGPASTALPGAPDASSAPCVVASLEAALGLVQAGRAAAL 118

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQ-----AKKVVMMLATEELRVALATTHLPLRD 171
           +T P+ K V+   G PF GHTEF   R+      A   VMM+ +E+L V  AT HLP  D
Sbjct: 119 VTNPLAKSVMYAGGFPFPGHTEFLAARAARPGRPAPHPVMMIWSEQLAVVPATIHLPYAD 178

Query: 172 IADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLN 231
           +   +T  LL E   I+  D+  +FG+A PR++ CGLNPHAGE G +GTE+   + P + 
Sbjct: 179 VPGHLTIDLLVETGRIVAGDMARRFGLAHPRLVFCGLNPHAGEEGTLGTEDEAIVRPAVE 238

Query: 232 ELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFI 291
            L+ +G+   GPLPADTLF P+     D  + MYHDQ L   K   F  GVN+TLGLPFI
Sbjct: 239 ALKREGIDARGPLPADTLFHPQARAGYDVAVGMYHDQVLIPAKTLAFHDGVNVTLGLPFI 298

Query: 292 RTSVDHGTALELAGRGKADVGSFI 315
           RTS DHGTA ++AG G+A+  S +
Sbjct: 299 RTSPDHGTAFDIAGTGRANPSSLV 322


>UniRef50_C1SJH6 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Denitrovibrio
           acetiphilus DSM 12809 RepID=C1SJH6_9BACT
          Length = 322

 Score =  207 bits (528), Expect = 3e-52,   Method: Compositional matrix adjust.
 Identities = 118/328 (35%), Positives = 177/328 (53%), Gaps = 10/328 (3%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           +K  ++ IT G+P+GIGP++  +LA      E     DA  ++           ++    
Sbjct: 3   MKKPKIAITTGDPSGIGPEIACRLASELDGSEEY---DAVFISYEN-------VIKSAFE 52

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           N    P    T+      L   +  G +  E G   +  + +A    ++GE  A++T P+
Sbjct: 53  NIIKAPMPEMTIIEPDEKLDLKIEHGLIKPEYGKASMLYVEKAVQMAMSGEVDAVVTCPI 112

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           +K  I   G  + GHTEF    ++ +   M++  + +R  LATTH+P+ ++ D +    +
Sbjct: 113 NKASIKAGGYNYPGHTEFLGYLTRTRYFSMLMVGKNIRTVLATTHVPMAELVDKLDENSI 172

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
              I   H   +   G  +P+I VCGLNPHAG+ G +G EEI  I PV++  RA GM + 
Sbjct: 173 MNAIVNAHEAGQFFCGKRQPKIAVCGLNPHAGDNGALGDEEITLITPVIDIARAGGMDVE 232

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP PAD+LF        D V+ MYHDQGL  +K + FG  VN+TL LP IRTSVDHGTA 
Sbjct: 233 GPFPADSLFPKAAKGEYDFVVVMYHDQGLIPVKLEAFGNAVNVTLNLPIIRTSVDHGTAF 292

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNTQ 329
           E+AG+G AD  S I A+++A++M+ N Q
Sbjct: 293 EIAGKGIADHHSLIRAIDVAVEMVKNAQ 320


>UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic protein pdxA n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q0V0_9BACT
          Length = 346

 Score =  206 bits (523), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 123/326 (37%), Positives = 177/326 (54%), Gaps = 16/326 (4%)

Query: 9   ITPGEPAGIGPDLVVQ-LAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYS----- 60
           IT G+P GIGP+++V+ LA    +     ++  +  +L + A  L +P   R  S     
Sbjct: 20  ITMGDPCGIGPEIIVRSLASSALKRAANYIIIGNQAVLDSTAQSLKIPFRYRVVSLETDI 79

Query: 61  --PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
              ++P    ++    L  +  R P   G      G      + +  D  L G+  AL+T
Sbjct: 80  ERVSTPISLLSSEHFDLNLIKKRLPTAEG------GELSFLWIKKGIDLALQGKINALVT 133

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P+ K  I+ AG  + GHTE   + S+ K+VVM++    LRVA  TTH+ L ++A +IT 
Sbjct: 134 APICKEAIHMAGYQYPGHTEILRDLSKVKRVVMLMIGGSLRVAFVTTHIALHEVAQSITV 193

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + E I I +  L+  F    PRI VCG+NPHAGE G  G EE + I+P + + +  G+
Sbjct: 194 KNVLETITICNTYLKKYFTPRNPRIAVCGVNPHAGEEGIFGNEEKNIIVPAVKKAKKLGV 253

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           + NGP+ ADT+F        D V++MYHDQG   LK   F  GVNITLG+PFIRTS DHG
Sbjct: 254 ECNGPVSADTVFYKALKGQYDLVVSMYHDQGAIPLKLHAFETGVNITLGIPFIRTSPDHG 313

Query: 299 TALELAGRGKADVGSFITALNLAIKM 324
           TA ++AG+G A+  S   A+  AI M
Sbjct: 314 TAYDIAGKGIANPDSMKEAIMTAIMM 339


>UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Lactobacillus
           paracasei subsp. paracasei 8700:2 RepID=C5F751_LACPA
          Length = 326

 Score =  205 bits (522), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 117/324 (36%), Positives = 183/324 (56%), Gaps = 6/324 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQ--LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           T  + IT G+P+GIGP++ ++  +   ++  E ++     ++T  A +L +   L     
Sbjct: 2   THFIGITIGDPSGIGPEISLKALMKNEQYLNESIIFGSKEIMTYYADLLKIKTPLNFIKD 61

Query: 62  NSPAQPQTAGTLTLLPVAL-RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
               +        ++ + L + P+  G+++  +G    + L  A D  +  +   ++T P
Sbjct: 62  VDQFEAGKINIYNVMDIPLDKIPI--GEVSPISGDAAFQFLKVAIDLAMKKKIGPVVTAP 119

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           ++K  ++  G  F GHTE F E +  KK  MML +++L V   +TH+PLR   D +T A 
Sbjct: 120 LNKDALHKGGHNFDGHTEIFAEFTGTKKYTMMLWSKKLAVVHVSTHVPLRKACDLVTKAR 179

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           + E I + +  ++ + GI++PRI V GLNPHAGE G  G EEI  I P + E ++QG+ +
Sbjct: 180 VEECIDLANSAIK-RLGISKPRIAVAGLNPHAGEDGLFGDEEIKEINPAVKEKQSQGIDV 238

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            G LP DT+F        D V+AMYHDQG   +K   F  GVN+TLGLP IRTSVDHGTA
Sbjct: 239 QGALPPDTVFLKASQGKFDIVVAMYHDQGHIPMKLLAFDEGVNVTLGLPIIRTSVDHGTA 298

Query: 301 LELAGRGKADVGSFITALNLAIKM 324
            ++AG+G A+  S + ++ LAIK 
Sbjct: 299 FDIAGKGIANESSMLASIALAIKF 322


>UniRef50_C8QYR8 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QYR8_9DELT
          Length = 342

 Score =  205 bits (521), Expect = 2e-51,   Method: Compositional matrix adjust.
 Identities = 125/335 (37%), Positives = 181/335 (54%), Gaps = 22/335 (6%)

Query: 12  GEPAGIGPDLVVQL---------------AQREWPVELVVCADATLLTNRAAMLGLPLTL 56
           G PAG+GP+++++L                ++E     VV  D  +L   A  LG+ + L
Sbjct: 2   GCPAGVGPEIILRLHLEREQARQAGTTETGRQEPAAAAVVLGDLGVLAQCARQLGVKVEL 61

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPV-TAGQLAVENGHYVVETLARACDGCLNGEFAA 115
            P+ P    QP  +G L +LPV   AP+ + G+  V +G  + E + +A     +GE AA
Sbjct: 62  NPWQPG---QPLGSGALNVLPVTSLAPLPSPGRPTVASGRAMGEYIEQAVALAQSGELAA 118

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           ++T P+ K ++N  G  + GHTE         +  MM+A   LRV+L + H PL  + +A
Sbjct: 119 MVTCPIGKDMLNAGGYHYPGHTEMLATLCNCSEYAMMMAGARLRVSLVSIHRPLSRVPEA 178

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE--- 232
           +T   +  +I +    L+  F +  PR+ V  LNPHAGEGG  G EE   I P + +   
Sbjct: 179 VTQEAVVRLIRLTARSLQHDFAVLRPRLAVAALNPHAGEGGMFGDEEKRVIEPAVAQAAA 238

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
           L  + + ++GP P DT+F      + DAV+AMYHDQGL   K   F  GVN+T+GLP IR
Sbjct: 239 LLGREVSISGPRPPDTVFYQASQGDFDAVVAMYHDQGLIPFKLLHFKDGVNVTIGLPIIR 298

Query: 293 TSVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           TSVDHGTA ++AGRG AD  S   A  LA ++  N
Sbjct: 299 TSVDHGTAYDIAGRGVADHDSLRAAFWLAAEIAAN 333


>UniRef50_C6XKP9 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Hirschia
           baltica ATCC 49814 RepID=C6XKP9_HIRBI
          Length = 339

 Score =  204 bits (519), Expect = 4e-51,   Method: Compositional matrix adjust.
 Identities = 125/328 (38%), Positives = 178/328 (54%), Gaps = 12/328 (3%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVE--LVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           + +T G+PAG+GP L  +   +    +    V A + +L N   + G+   ++     +P
Sbjct: 7   LAVTMGDPAGVGPILTWRAWHQRSTTQRPFFVIASSDILKNSQELSGVDGNIQII--QTP 64

Query: 65  AQPQTAGTLTLLPVALRAPVT-AGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
           A  + A   +L  + +  P T  GQ   E+   ++ ++ +A +     + A ++T P++K
Sbjct: 65  ADAEKAFHTSLPVLEIECPDTKTGQPNPESAAAIIASIEKAVEFTFENKAAGVVTNPINK 124

Query: 124 GVINDAGIPFTGHTEFFEE-------RSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            ++   G  F GHTEF  E        S+A   +MML    LRVALAT H PLR + D +
Sbjct: 125 ALLYKKGFKFPGHTEFLAELARQHTHMSKAPLPIMMLVGGGLRVALATIHEPLRKVPDLL 184

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           T +L+ EV  I+H  L   FG + P I + GLNPHAGE G +G EEI+ I P    LR +
Sbjct: 185 TQSLIEEVSNIVHAGLVRNFGFSSPTIALAGLNPHAGEEGSLGMEEIEQINPAAAALRQR 244

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G++++   P DT+F        DAV+AMYHDQGL  LK      GVN+TLGLPFIRTS D
Sbjct: 245 GLQISDAQPGDTVFHAMLEGQFDAVIAMYHDQGLAPLKSLDMWGGVNVTLGLPFIRTSPD 304

Query: 297 HGTALELAGRGKADVGSFITALNLAIKM 324
           HGT   +A  G A   S I A+NLA  M
Sbjct: 305 HGTGYGVAADGSARPDSLIAAINLASDM 332


>UniRef50_A0LA33 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Magnetococcus
           sp. MC-1 RepID=A0LA33_MAGSM
          Length = 346

 Score =  204 bits (518), Expect = 5e-51,   Method: Compositional matrix adjust.
 Identities = 128/337 (37%), Positives = 185/337 (54%), Gaps = 17/337 (5%)

Query: 7   VVITPGEPAGIGPDLVVQL---AQREWPVEL-----VVCADATLLTNRAAMLGL-PLTLR 57
           + +T G+PAGIGP++V++     QRE    L     +   D  +L   A  +GL P  L+
Sbjct: 6   IALTMGDPAGIGPEIVLKAFAQQQRERQKRLAGAKWLWVGDPEVLLWTAQQMGLVPPKLQ 65

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLA--VENGHY---VVETLARACDGCLNGE 112
                +         L +LP  L A +   +LA  V +G +   VVE++  A    ++G+
Sbjct: 66  RVRQAAEVAQVADEVLAVLP--LEACIDRHKLAFGVADGAHAKAVVESIETATALAMSGQ 123

Query: 113 FAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDI 172
              ++T P+HKGV++  G  + GHTE     +     VMMLA   LRV  AT H  +R +
Sbjct: 124 VGGVVTPPIHKGVLHAGGYRWPGHTELLGHCTGVTTPVMMLAGRGLRVVPATIHQSIRSV 183

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
            D+++ A L ++ +++ H L+  FG+ EPRI +C LNPHAGEGG  G EE   I P +  
Sbjct: 184 PDSLSVAKLTQIFSVVGHSLQQDFGLREPRIAICALNPHAGEGGAFGDEERRIIQPAMAA 243

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
           L  + ++L GP PAD LF         A++ MYHDQ L  +K   FG   NITLGLP IR
Sbjct: 244 LMGE-VRLEGPFPADALFSEAARAPYGAIICMYHDQALIPIKMHCFGEATNITLGLPIIR 302

Query: 293 TSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           TSVDHGTA ++AG G+A  G+ + A+  A +M  N +
Sbjct: 303 TSVDHGTAYDIAGSGRAKHGALLIAVEQAARMAANRR 339


>UniRef50_B1L710 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Korarchaeum cryptofilum OPF8 RepID=B1L710_KORCO
          Length = 316

 Score =  202 bits (513), Expect = 2e-50,   Method: Compositional matrix adjust.
 Identities = 126/323 (39%), Positives = 180/323 (55%), Gaps = 16/323 (4%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           V++T G+P G+GP+++V+  +R   + + V      L       GL +   P    +P +
Sbjct: 4   VIVTAGDPLGVGPEVLVKAIKR-LGLPVTVIGSIRSLKKACESCGLDMDFTPVDEPTPLR 62

Query: 67  PQT-AGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
                  +    V    P        E G +    + +A +  L G+  AL+TGPV K  
Sbjct: 63  DSVPVIDIDDFGVEGSGPTP------EGGLHSYLCIRKASELILGGKAEALVTGPVSKEA 116

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
           +N AGI FTGHTE   E +  +K  MML  +ELRV+  TTH+ L+D+     P LL E  
Sbjct: 117 VNMAGIKFTGHTELLAELAGGRKTKMMLFLDELRVSHVTTHVALKDV-----PRLLTEEE 171

Query: 186 AILHHDLRTKF--GIAEP-RILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
            I+  +L + F   + EP +I V  LNPHAGEGG  G EEI  I P + +L  +G ++ G
Sbjct: 172 IIVTVELTSSFLGKLGEPGKIGVSSLNPHAGEGGLFGDEEIRIIRPAIEKLIDRGYEVEG 231

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
           P+PADT+F         AV+AMYHDQG   +K  GF R VN+TLGLP++RTSVDHGTA +
Sbjct: 232 PIPADTIFLRAMRGEFKAVVAMYHDQGHIPIKLLGFNRAVNVTLGLPYVRTSVDHGTAYD 291

Query: 303 LAGRGKADVGSFITALNLAIKMI 325
           +AG+  AD GS + A+ LA +++
Sbjct: 292 IAGKCLADEGSMVNAIRLAFRLL 314


>UniRef50_B2V9E6 4-hydroxythreonine-4-phosphate dehydrogenase n=5 Tax=Aquificales
           RepID=PDXA_SULSY
          Length = 322

 Score =  201 bits (512), Expect = 2e-50,   Method: Compositional matrix adjust.
 Identities = 116/319 (36%), Positives = 179/319 (56%), Gaps = 8/319 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           ++ IT G+P+GI  +++++   +  +  +  V+      L     + G+ L ++     +
Sbjct: 3   KLAITLGDPSGINSEILLKALNKLPKRNISYVIYGSKKALEKAKKLTGVDLNIKEIKSIN 62

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
                    + L  +     V  G  + E G   V  L  A    L  +  ALIT P+ K
Sbjct: 63  DVVKSGIYLINLYDL----DVEFGSSSKETGKASVVYLENAVKDVLEKKADALITLPISK 118

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             I ++G P+ GHT++  E S AK+  M+L  ++L+VAL TTH+PL+D+   IT   +  
Sbjct: 119 QWIMESGFPYAGHTDYLAEVSGAKEYAMVLMCKKLKVALITTHIPLKDVPSQITKEKIIS 178

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            + +++ + + KFGI++P+I + GLNPHA + G++G EE + I+P +  LR  G+++  P
Sbjct: 179 KVRLINREFKEKFGISKPKIAILGLNPHASDNGNIGNEEQNIILPAVKTLREDGIEITDP 238

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           L  DT F  +Y D  D  +AMYHDQGL  LK   F + VNITLGLPFIRTS DHGT  ++
Sbjct: 239 LSPDTAFN-RYKD-FDIYVAMYHDQGLIPLKLLCFRKAVNITLGLPFIRTSPDHGTGYDI 296

Query: 304 AGRGKADVGSFITALNLAI 322
           AG+  AD  S I A+ LAI
Sbjct: 297 AGKNIADPSSTIEAVELAI 315


>UniRef50_Q0FGB3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Rhodobacterales RepID=Q0FGB3_9RHOB
          Length = 325

 Score =  201 bits (511), Expect = 3e-50,   Method: Compositional matrix adjust.
 Identities = 128/324 (39%), Positives = 174/324 (53%), Gaps = 14/324 (4%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWP--VELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           V +T G+P GIG D+  + A++E    +   + AD   L  RA          P    + 
Sbjct: 5   VALTCGDPNGIGIDISFE-AKKELKNRIPFFLIADINHLKKRAHAQSFVKIQHPKECFNI 63

Query: 65  AQPQTAGTLTLLPVALRA-PVTAGQLAVENGHYV--VETLARACDGCLNGEFAALITGPV 121
           ++        +LPV     P T      + G+ +   E + RA D   N E  A+ T P+
Sbjct: 64  SK-------DILPVLHHEFPETPTLNGSQPGNALATTEVIERAVDLFQNHEIHAICTNPI 116

Query: 122 HKGVIND-AGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           +K V+ +  G  + GHTE+    +  K  VMML  EELRV   T H+ L+D++  +T  L
Sbjct: 117 NKEVLKEGCGFEYPGHTEYLANLAGHKNSVMMLLCEELRVVPTTIHIALKDVSKLLTKEL 176

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           L   I      L   FGI +PR+ + GLNPHAGE G  G EEI  I P + +LR+QG  +
Sbjct: 177 LINTINTTRDALINHFGIKKPRVAISGLNPHAGENGIFGQEEIKIINPTIEKLRSQGFDI 236

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GPL ADT+F  +  +N D  + MYHDQ L  +K   F  GVN+TLGLPFIRTS DHGTA
Sbjct: 237 IGPLSADTMFHKEARNNYDVAICMYHDQALIPIKTIDFYGGVNVTLGLPFIRTSPDHGTA 296

Query: 301 LELAGRGKADVGSFITALNLAIKM 324
            ELAG  KA+  S I+AL +A K+
Sbjct: 297 FELAGTRKANPRSLISALEVAYKI 320


>UniRef50_C6X2C9 4-hydroxythreonine-4-phosphate dehydrogenase n=3
           Tax=Flavobacteriales RepID=C6X2C9_FLAB3
          Length = 363

 Score =  198 bits (504), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 119/327 (36%), Positives = 179/327 (54%), Gaps = 6/327 (1%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPN 62
           RV I+ G+  GIGP+++++  + +   +    ++     L T +  +  L +     +  
Sbjct: 9   RVGISIGDFNGIGPEIIMKTLKDKSITDFFTPIIFGSGKLFTYQKNIFKLQINFNYITEA 68

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
             AQ      + L   A    V  G+   E+    +E+L  A D  + G+   L+T P++
Sbjct: 69  LQAQSDKINMVNL--TADNVNVDLGKPTEESTRMAIESLEAATDALVRGDIDVLVTAPIN 126

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K  +   G    GHT + EE+ Q KK +M L +E L+VA++T H+P+  +A+ I+   + 
Sbjct: 127 KDEMIKHGFAHAGHTGYLEEKFQ-KKGLMFLVSEGLKVAVSTHHIPISQVAENISKEKIK 185

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
           + I IL+  L   F I+ P+I V GLNPHAG+GG +G EEI+ I P + ++   G+   G
Sbjct: 186 KQIKILNQCLIEDFQISLPKIAVLGLNPHAGDGGVIGNEEIEIIQPAVKDVFDNGILAFG 245

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
             PAD+ FQP      DAVLAMYHDQGL   K   +  GVN T GLP+IRTS DHG A +
Sbjct: 246 AFPADSFFQPSKYTKFDAVLAMYHDQGLAPFKTLAYEEGVNYTAGLPYIRTSPDHGVAYD 305

Query: 303 LAGRGKADVGSFITALNLAIKMIVNTQ 329
           +AG+  AD  SF  A+ +AIK+  N Q
Sbjct: 306 IAGQNLADEQSFSEAIFMAIKIFKNRQ 332


>UniRef50_A3ERM0 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Leptospirillum
           RepID=A3ERM0_9BACT
          Length = 344

 Score =  198 bits (504), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 127/328 (38%), Positives = 176/328 (53%), Gaps = 23/328 (7%)

Query: 7   VVITPGEPAGIGPDLVVQ--LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP--- 61
           + IT G+PAGIGP+++V+  L      +  +V  D  L+   A         R YSP   
Sbjct: 15  LAITMGDPAGIGPEIIVKGWLENEIRDLPRIVIGDPDLIAEVA---------RKYSPELL 65

Query: 62  ----NSPAQ-PQTAGTL-TLLPV--ALRAPVTAGQLAVENGHYVVETLARACDGCLNGEF 113
               +SP   P+  G L  LLP    +  PV+ G   V  G +    +    +  + G  
Sbjct: 66  VQQIDSPEHAPRDPGILGVLLPEHEDILEPVSPGTSQVMAGRWAYYCVRTGVELAMAGRV 125

Query: 114 AALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIA 173
           A ++T P++K V++ AG  + GHTE     +   +  MML    L+V L TTH+P R+IA
Sbjct: 126 AGIVTAPLNKKVLHAAGFNYPGHTELIAHLTNTPRYGMMLVGGPLKVILVTTHIPFREIA 185

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL 233
             IT   + E I  L  +      IA P+I V  LNPHAGE    G EE   I P + E 
Sbjct: 186 GKITKERVLETIQ-LAREAMDMLKIASPKIAVAALNPHAGEASLFGDEEKTCIFPAILEA 244

Query: 234 RAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
           RA+G+++ GPLPADTL+        D V++ YHDQGL  LK   FG+G+N+T+G+P IRT
Sbjct: 245 RAEGIEVEGPLPADTLYAKAAQGRFDIVVSQYHDQGLIPLKMLSFGQGINVTVGIPIIRT 304

Query: 294 SVDHGTALELAGRGKADVGSFITALNLA 321
           SVDHGTA ++ G+G A  GS I A+ LA
Sbjct: 305 SVDHGTAYDIVGKGIAQPGSLIKAIRLA 332


>UniRef50_P58718 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=29 Tax=Bacteria
           RepID=PDXA2_SALTY
          Length = 327

 Score =  198 bits (503), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 122/329 (37%), Positives = 186/329 (56%), Gaps = 9/329 (2%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREW----PVELVVCADATLLTNRAAMLGLPLTLR 57
           ++T+ V IT G+PAGIGP+++V+    +     P+ ++ C  ATL   +A  +   + LR
Sbjct: 1   METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCL-ATLKRLQAKGITPNVELR 59

Query: 58  PYSPNSPAQPQTAGTLTLL--PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
                + A+    G + ++  P+A    + AG++  + G      + RA +  L G+  A
Sbjct: 60  AIERVAEAR-FAPGIIHVIDEPLAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQA 118

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           + T P++K  ++ AG  + GHTE     + ++   M+L T++L+V   +TH+ LR   D 
Sbjct: 119 IATAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDKLKVIHVSTHIALRKFLDT 178

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           ++ A +  VI I    L+ + G  +PRI V G+NPHAGE G  G EE   + P + + RA
Sbjct: 179 LSTARVETVIGIADTFLK-RVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARA 237

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +GM + GP P DT+F   Y    D V+AMYHDQG   LK  GF  GVNIT GLPFIRTS 
Sbjct: 238 KGMDVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSA 297

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKM 324
           DHGTA ++A  GKA   S   ++ LA+++
Sbjct: 298 DHGTAFDIAWTGKAKSESMAVSIKLAMQL 326


>UniRef50_Q8CUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=45 Tax=Bacteria
           RepID=PDXA_OCEIH
          Length = 332

 Score =  196 bits (499), Expect = 8e-49,   Method: Compositional matrix adjust.
 Identities = 120/329 (36%), Positives = 184/329 (55%), Gaps = 6/329 (1%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQ-LAQREWPVEL--VVCADATLLTNRAAMLGLPLTLR 57
           M K   + IT G+ AG+GP+++++ L  RE   +   +V  D  +L   A +L + ++  
Sbjct: 1   MSKKPIIGITMGDAAGVGPEIIIKSLRNRELYEQAHPIVIGDTKMLERAAKILDVDVSFD 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVA-LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
             + +        G +T + +  L   +  G+++  +G+   E L  A +    G+  A+
Sbjct: 61  KKTKDEELMDTEFGKITCIDLDILPEDLAYGEVSPVSGNAAFEYLRMAIELANEGKIQAI 120

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  +   G  + GHTE   E +  ++  MML++ +L+V   TTH+ L      I
Sbjct: 121 CTAPLNKEALQKGGHMYPGHTEILAELTNTEEFSMMLSSPKLKVIHVTTHVGLIQAIQMI 180

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRA 235
            P  +H+VI + H  L +  GI  P+I VCG+NPHAGE G  G  EE + IIP + +   
Sbjct: 181 KPERVHKVIQLAHETL-SNSGIKNPKIGVCGINPHAGENGLFGNGEEEEKIIPAIQQAVK 239

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G+ + GPLPADTLF      + D V+AMYHDQG   +K  G   GVNIT+GLP IRTSV
Sbjct: 240 EGINVEGPLPADTLFFRAQRGDFDIVVAMYHDQGHGPIKVLGLEAGVNITVGLPIIRTSV 299

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKM 324
           DHGTA ++AG+G  D  S + AL+ AI++
Sbjct: 300 DHGTAFDIAGKGIVDERSMLEALHQAIEL 328


>UniRef50_Q2S3U3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Rhodothermaceae RepID=Q2S3U3_SALRD
          Length = 402

 Score =  196 bits (498), Expect = 9e-49,   Method: Compositional matrix adjust.
 Identities = 118/324 (36%), Positives = 170/324 (52%), Gaps = 6/324 (1%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREW---PVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           R+ IT G+P GIGP++V++          +  V+   A +L   A +LG    L  +  +
Sbjct: 68  RLAITLGDPNGIGPEVVLKSLHDPSLMPSMTPVLIGSAHVLRVHADVLGFS-DLDIHIVD 126

Query: 63  SPAQPQTAGTLTLLPVAL--RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
              +    G + +L VA     PV  G +  E G   +  + RA + C  G   A++T P
Sbjct: 127 EVPEEVPHGDVAVLDVAEDPEPPVMFGSITAEGGRLAMRAVERAVEACQAGTVDAMVTAP 186

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           + K  +   G    GHTEF  +++ + +  MM+    LRV L T+H  L ++  A+T   
Sbjct: 187 ISKDAVRQGGYDVPGHTEFLADKTNSPQPTMMMVAGGLRVGLVTSHTALSEVPSAVTEEA 246

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           + E + ++   LR  F I +P+I V GLNPHAGE G  G EE + I P L   R +G ++
Sbjct: 247 ILEKLRVIDASLRDDFAIEQPKIAVFGLNPHAGEAGAFGQEEEEVIAPALRAARQEGFRV 306

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+ AD  F  +   + DA LAMYHDQGL   K   F  GVN T GLP +RTS DHGTA
Sbjct: 307 EGPMAADGFFGTQLDADHDAALAMYHDQGLVPFKALAFDHGVNYTAGLPIVRTSPDHGTA 366

Query: 301 LELAGRGKADVGSFITALNLAIKM 324
             +AG+G A  GS   A+ LA+ +
Sbjct: 367 YGIAGKGMALPGSMRNAMELAVAI 390


>UniRef50_C6VZ75 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Dyadobacter
           fermentans DSM 18053 RepID=C6VZ75_DYAFD
          Length = 368

 Score =  195 bits (496), Expect = 2e-48,   Method: Compositional matrix adjust.
 Identities = 114/317 (35%), Positives = 167/317 (52%), Gaps = 5/317 (1%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLP-LTLRPYSPNSP 64
           IT G+  GIGP+++++  +     +L   ++     +L     +L +   TL        
Sbjct: 13  ITIGDYNGIGPEVILKALEGNQLAKLCTPIIYGSLRVLNQYRNLLEMKDWTLHGIQKAEQ 72

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
           A  +    +T      +  +  G++  E G      L RA +    G   AL+TGP++K 
Sbjct: 73  ANHKLTNVITCWH-DHQTEIQPGKITAEAGQGSFAALKRAVEDLKEGRIQALVTGPINKD 131

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
            I +    F GHTEF  +  +    +M +   +LRV + T H+PL+++ + ITP  L   
Sbjct: 132 NIQNDDFKFPGHTEFLAQSFEKDDALMFMVAGDLRVGVLTGHMPLQNVREHITPEKLSAK 191

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL 244
           I  +   L+  FGI +P++ V GLNPHAGE G +G+EEI+ I PV+ + + +G  + GP 
Sbjct: 192 IEQILQSLKGDFGIKKPKLAVLGLNPHAGENGLLGSEEIEIIQPVIKQFKEKGHLVVGPF 251

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELA 304
           PAD  F        DAVLAMYHDQGL   K   F  GVN T GLP +RTS DHGTA  +A
Sbjct: 252 PADGFFAAGTYRQYDAVLAMYHDQGLIPFKTLAFNEGVNFTAGLPAVRTSPDHGTAYNIA 311

Query: 305 GRGKADVGSFITALNLA 321
           G+  A+ GS + AL LA
Sbjct: 312 GKNVAEPGSLLQALYLA 328


>UniRef50_Q89NF3 4-hydroxythreonine-4-phosphate dehydrogenase 1 n=8
           Tax=Proteobacteria RepID=PDXA1_BRAJA
          Length = 345

 Score =  195 bits (495), Expect = 2e-48,   Method: Compositional matrix adjust.
 Identities = 124/338 (36%), Positives = 182/338 (53%), Gaps = 21/338 (6%)

Query: 4   TQRVVITPGEPAGIGPDLVVQ----LAQR--EWPVELVVCADATLLTNRAAMLGLPLTLR 57
           ++ + IT G+PAGIGP+++V+    L  R     + L++      L    A LG  + + 
Sbjct: 3   SRHLAITMGDPAGIGPEIIVKACLGLKGRIATGDLRLLIIGSGAALDGAKAALGTDVAIP 62

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
             S +    P       L   A   P+  G L+ + G +  + + +       G  AA++
Sbjct: 63  QVSADDREWPNLC---YLQADAEGDPIKPGVLSADGGRFAYKAIEQGVRLTQAGRTAAIV 119

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           T P++K  +N AG  F GHTE     +  +  VM+LA   +RV+  +TH+ L D+   +T
Sbjct: 120 TAPLNKEALNKAGYHFPGHTEMLAHLTGVRGSVMLLAHGNMRVSHVSTHVALEDVPKRLT 179

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
           P  L  VI + +  LR + GIA+P+I V  LNPHAGEGG  G ++ID   P + +  A G
Sbjct: 180 PERLRMVIDLTNDALR-RLGIAKPKIAVAALNPHAGEGGLFGRQDIDVSAPTIAKAVADG 238

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGF------GR-----GVNITL 286
           + + GP+P DT+F        DA +AMYHDQG   +K  GF      GR     GVNITL
Sbjct: 239 LDVIGPVPGDTIFVKLRAGQFDAAVAMYHDQGHIPVKLLGFQVDPATGRWQELSGVNITL 298

Query: 287 GLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           GLP IRTSVDHGTA ++AG+G A+  S I A++ A ++
Sbjct: 299 GLPIIRTSVDHGTAFDIAGKGIANEHSLIEAIDYAERL 336


>UniRef50_A6FY83 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Plesiocystis
           pacifica SIR-1 RepID=A6FY83_9DELT
          Length = 327

 Score =  194 bits (494), Expect = 3e-48,   Method: Compositional matrix adjust.
 Identities = 130/329 (39%), Positives = 177/329 (53%), Gaps = 25/329 (7%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           ++VIT G+P G+GP+L++++A      E V+  +  +   RA + GL  +L        A
Sbjct: 3   QLVITQGDPDGVGPELLLRMA-----AEGVLLPEDRVFAGRAKLRGLAESL----TAEWA 53

Query: 66  QPQTAGTLTLL--PVALRAPVTA-GQL-AVENGHYVVETLARACDGCLNGEFAALITGPV 121
            P  A    LL   +A R P    GQ  A+E G      + R  +    G  AAL+T P+
Sbjct: 54  APGWAKLEPLLDPSLAERDPSAPLGQFEALERG------VDRVLEDVRKGAPAALVTAPI 107

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
            K V +  G+   GHTE+  ER+  +   M++A   +RV LAT HLPLR + +A+  A +
Sbjct: 108 DKAVASREGLRHPGHTEYLAERAGVEDFAMLMAGSTIRVVLATIHLPLRAVVNALDQAAI 167

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG---- 237
               ++L   L   +G+AEP + V GLNPHAGEGG +G EE   I P +  L A      
Sbjct: 168 VRAGSLLARSLVQDYGVAEPVVGVLGLNPHAGEGGLLGDEEQTLIAPAIEALGAWAAQAQ 227

Query: 238 --MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
              +  GPLPADT F          ++AMYHDQGL   K   F  GVN+TLGLPF+RTS 
Sbjct: 228 IPARFVGPLPADTAFHHNRGGRVHGLVAMYHDQGLGPFKLAHFSDGVNVTLGLPFVRTSP 287

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKM 324
           DHGTA ++AGRG AD  S   A+ LA  M
Sbjct: 288 DHGTAKDIAGRGVADASSMRAAIELARAM 316


>UniRef50_D1UTB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Burkholderia
           sp. CCGE1001 RepID=D1UTB0_9BURK
          Length = 784

 Score =  193 bits (491), Expect = 7e-48,   Method: Compositional matrix adjust.
 Identities = 129/332 (38%), Positives = 180/332 (54%), Gaps = 17/332 (5%)

Query: 9   ITPGEPAGIGPDLVVQL---AQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           IT G+ AG+GP+++++    A        +V  D+  L +     G+ L++RP +  + A
Sbjct: 457 ITMGDAAGVGPEIIMKSLAHASVYDGCRPLVIGDSKRLVDAGQRTGVTLSVRPIASPAEA 516

Query: 66  QPQTAGT----LTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           + Q        L L+P    A +  G+L+   G    + +AR  +    GE  A+ T P+
Sbjct: 517 RFQYGEVDCIDLGLIP----ADLPYGKLSAVAGDAAYQYIARTVELTSAGELDAICTAPL 572

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           +K  ++  G  F GHTE     +   +V MML   +LRV   TTH+ L D    I P L+
Sbjct: 573 NKEALHAGGHIFPGHTEMLAHLTGIPEVSMMLVAPKLRVIHVTTHIGLLDAIRRIEPGLV 632

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRAQGMKL 240
              I   H  L  + GI EPRI VCG+NPHAGE G  G  EE + I+P +  LR +G  +
Sbjct: 633 QRTIERAHETL-VRAGIDEPRIGVCGINPHAGENGLFGYGEEEEKIVPAVAVLRERGWDV 691

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GPLPADTLF      + D V+AMYHDQG   +K  G   GVN+T+GLP IRTSVDHGTA
Sbjct: 692 EGPLPADTLFFRAGRGDFDVVVAMYHDQGHGPVKVMGLEAGVNVTVGLPVIRTSVDHGTA 751

Query: 301 LELAGRGKADVGSFITAL----NLAIKMIVNT 328
            ++AG+G AD  S + AL    +LA +  V T
Sbjct: 752 FDIAGKGIADERSMLEALKQAEDLATRRAVQT 783


>UniRef50_A1VC56 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Desulfovibrio
           RepID=A1VC56_DESVV
          Length = 428

 Score =  192 bits (489), Expect = 9e-48,   Method: Compositional matrix adjust.
 Identities = 107/244 (43%), Positives = 143/244 (58%), Gaps = 4/244 (1%)

Query: 84  VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEER 143
           V  G+  V  G      L+ ACD    G    ++T P+HK +++ AG    GHTE+   R
Sbjct: 182 VRVGEATVSGGCAAGVALSAACDLLCAGVVPGVVTLPLHKAMLHTAGFDVPGHTEYLARR 241

Query: 144 S--QAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEP 201
           +     +V M L  + LRV+L TTH PLR++AD +T   +   + +    +R   G+  P
Sbjct: 242 AGLADDEVCMHLCGDRLRVSLVTTHPPLREVADLVTRERVLRCLRLTAAFVRA-LGLQGP 300

Query: 202 RILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAV 261
            + VCGLNPHAGE G +G EEI+ I P + + R +G+ ++GP PADTLF         AV
Sbjct: 301 -VAVCGLNPHAGESGRIGREEIEVITPAIEDARREGLAVDGPFPADTLFHRAAGGGYPAV 359

Query: 262 LAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLA 321
           LAMYHDQGL  LK   F   VN+TLGLPF+RTSVDHGT  ++AG G+A  GSF  AL LA
Sbjct: 360 LAMYHDQGLGPLKLLHFSDAVNVTLGLPFVRTSVDHGTGFDIAGTGRASTGSFTAALQLA 419

Query: 322 IKMI 325
             + 
Sbjct: 420 CMLC 423


>UniRef50_C4X874 4-hydroxythreonine-4-phosphate dehydrogenase n=15 Tax=Bacteria
           RepID=C4X874_KLEPN
          Length = 328

 Score =  192 bits (487), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 125/330 (37%), Positives = 181/330 (54%), Gaps = 15/330 (4%)

Query: 4   TQRVVITPGEPAGIGPDLVVQL----AQREWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
           ++ + +T G+PAGIGP+++++     A    PV +V CA  TL      +L L +T R  
Sbjct: 2   SKMIAVTMGDPAGIGPEIIIKSLAEGALSGAPVVVVGCAQ-TLRR----ILALNITPRAE 56

Query: 60  SP--NSPAQPQ-TAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFA 114
               + PA+   +  T+ ++   L  P  +  G++  + G      + RA    L G  A
Sbjct: 57  LRIIDHPAEASFSPATINVIDEPLSDPQGLRPGEVQAQAGDLAFRCIRRATALALEGAVA 116

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
           A+ T P++K  ++ AG  + GHTE     +Q     M+L TE+L+V   TTH+ LR   D
Sbjct: 117 AIATAPLNKEALHLAGHAYPGHTELLAHLTQTTDYAMVLYTEKLKVIHITTHISLRQFLD 176

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +    +  VI +    LR + G   PRI V G+NPHAGE G  G EEI  + P +  +R
Sbjct: 177 TLNQPRIETVIGVADRFLR-RVGYPRPRIAVAGVNPHAGENGLFGDEEIRIVAPAVAAMR 235

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           A+G+++ GP P DT+F   +    D V+AMYHDQG   LK  GF  GVNIT GLPFIRTS
Sbjct: 236 AKGVEVTGPCPPDTVFMQCHEGMYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTS 295

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKM 324
            DHGTA ++A  GKA   S  T++ LA+ +
Sbjct: 296 ADHGTAFDIAWTGKAKSESMATSIELAMHI 325


>UniRef50_C5T2H3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Burkholderiales RepID=C5T2H3_ACIDE
          Length = 230

 Score =  192 bits (487), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 103/229 (44%), Positives = 142/229 (62%), Gaps = 14/229 (6%)

Query: 109 LNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKK--------VVMMLATEELRV 160
           + G+ AAL+T P+HK  ++ AG+ F GHTE  +  + A +        V MMLA++ELR 
Sbjct: 1   MRGDIAALVTAPLHKEALSAAGVDFPGHTELLQAEAAAHQGVPLADMPVRMMLASDELRT 60

Query: 161 ALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT 220
            L + H+ LRD  DA+T   + + + I H  L    G A PR+ V GLNPH GEGG  G 
Sbjct: 61  VLVSIHVSLRDAIDAVTRDNVLQTLRITHAALLRSLGRA-PRMAVAGLNPHGGEGGLFGR 119

Query: 221 EEIDTIIPVLNELRAQGMKLNGPLPADTLFQ-----PKYLDNADAVLAMYHDQGLPVLKY 275
           EEI+ I+P + + RA GM ++GP   DT+F      P+     D VLAMYHDQGL  +KY
Sbjct: 120 EEIEHIVPAVADARALGMDVHGPFAPDTVFMRARHTPQRAGEFDVVLAMYHDQGLIPVKY 179

Query: 276 QGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
            G  +GVN+TLGLP +RTS DHGTA ++AG+G AD  S + A+ +A ++
Sbjct: 180 LGVDKGVNVTLGLPLVRTSPDHGTAFDIAGQGVADAASLVEAVRVARQL 228


>UniRef50_UPI0000D53337 pyridoxal phosphate biosynthesis protein n=1 Tax=Psychroflexus
           torquis ATCC 700755 RepID=UPI0000D53337
          Length = 249

 Score =  191 bits (485), Expect = 3e-47,   Method: Compositional matrix adjust.
 Identities = 96/249 (38%), Positives = 152/249 (61%), Gaps = 10/249 (4%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREW----PVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           + ++ +PG+PAGIGPDL + L    +       +V   D  L  +RA  LG    +  ++
Sbjct: 2   KTIIYSPGDPAGIGPDLFLSLLNENFFRFIKANVVCIGDHELFASRAEKLGYSFEINTFT 61

Query: 61  PNSPAQPQTAGTLTLLPVALRAP-VTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
             +    +  G L ++    + P ++ G+L   N  YV++ L    D C+N +   L+TG
Sbjct: 62  DINDVN-EKVGCLEII----KCPDISCGRLNAINSEYVIKNLDFGIDTCVNSKDIGLVTG 116

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P+ K  I + G  F+GHTE   E++ +  V+M+LA+E L+VALATTH+PL  ++++IT  
Sbjct: 117 PISKENIIEGGYSFSGHTERIMEKTNSDDVLMLLASERLKVALATTHIPLNKVSESITTD 176

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
           L+   + IL+H+L++KF I +P+I + GLNPHAGEGG +G EEI+TIIP + EL+A  + 
Sbjct: 177 LIINKVKILNHELKSKFNIEKPKISLLGLNPHAGEGGKLGKEEIETIIPAVKELKASNVD 236

Query: 240 LNGPLPADT 248
           ++ PL ADT
Sbjct: 237 VSMPLSADT 245


>UniRef50_C5ELY2 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Bacteria
           RepID=C5ELY2_9FIRM
          Length = 358

 Score =  190 bits (483), Expect = 5e-47,   Method: Compositional matrix adjust.
 Identities = 124/333 (37%), Positives = 179/333 (53%), Gaps = 19/333 (5%)

Query: 9   ITPGEPAGIGPDLVVQ-LAQREWPVEL--VVCADATLLTNRAAMLGLP-LTLRPYSPNSP 64
           IT G+PA IGP++ V+ LA  E   +   +V  DA ++     ++G   + + P      
Sbjct: 9   ITMGDPASIGPEITVKALANNEIYDKCRPLVIGDAGVMEAAVKIVGKEDVRIHPVHSVEE 68

Query: 65  AQPQTAGTLTLLPVAL--RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
           A  Q AGT+ +  + L     +  G+++V  G      + +     + GE    +T   +
Sbjct: 69  ALFQ-AGTIDVYDMDLVDMDKLERGKVSVMAGEAAFRYVEKVIQMAMAGEVDGTVTNAFN 127

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K  IN AG  ++GHTE + + +  KK  MMLA E +RV   +TH+ LR+  D +    + 
Sbjct: 128 KEAINMAGHHYSGHTEVYADMTGTKKYTMMLAHENIRVVHVSTHVSLREACDRVKKDRVL 187

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
           EVI I +   R   G+ +PRI V GLNPH+GE G  G EEID IIP +   +A+G++  G
Sbjct: 188 EVIRIAYQACR-DLGLEQPRIGVAGLNPHSGENGLFGREEIDEIIPAIEAAKAEGIQAEG 246

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGR-----------GVNITLGLPFI 291
           P+P DT+F        D V+AMYHDQG   LK  GF             GVNITLGLP +
Sbjct: 247 PVPPDTIFSKARGGWYDMVVAMYHDQGHIPLKVIGFVYNQEQQKWDAVAGVNITLGLPIV 306

Query: 292 RTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           R SVDHGTA + AG+G A+  S I A++  I++
Sbjct: 307 RASVDHGTAFDQAGQGIANELSLINAIDYGIRL 339


>UniRef50_D2QDF7 4-hydroxythreonine-4-phosphate dehydrogenase n=8 Tax=Bacteroidetes
           RepID=D2QDF7_9SPHI
          Length = 546

 Score =  190 bits (483), Expect = 5e-47,   Method: Compositional matrix adjust.
 Identities = 120/332 (36%), Positives = 178/332 (53%), Gaps = 15/332 (4%)

Query: 7   VVITPGEPAGIGPDLVVQLAQ--REWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           + I+ G+  GIGP+++++  Q  R   +   V   +  + NR   L   L L+ ++ N  
Sbjct: 210 IGISLGDYNGIGPEVILKALQYNRLQKICTPVIYGSMRILNRYRNL---LNLKDWNLNGA 266

Query: 65  AQPQTAGTLT--LLPVALRAP-----VTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
              QT G ++  L  V    P     +  GQ+  + G   +  L RA D   +G+  AL+
Sbjct: 267 ---QTIGQISHKLTNVITCWPDQNQDIQPGQVTADAGQAALACLQRAVDDLKDGKIDALV 323

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           T P++K  I      F GHTE+  +    +  +M L ++ LRV + T H+PL  +   IT
Sbjct: 324 TAPINKNNIQSDEFKFPGHTEYLAQEFGVQDNLMFLVSQTLRVGVVTGHVPLGRVRQNIT 383

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              + + + ++ H L+  FGI +P+I V GLNPHAGE G +GTEE D I P++ + R +G
Sbjct: 384 RERIAQKLTLMMHSLKQDFGIEKPKIAVLGLNPHAGEEGLLGTEENDIIKPLIADWRNKG 443

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
             + GP PAD  F  +     DAVLAMYHDQGL   K   F  GVN T G+P +RTS DH
Sbjct: 444 QLVFGPYPADGFFGTRAYTKFDAVLAMYHDQGLIPFKAIAFEEGVNFTAGMPAVRTSPDH 503

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           GTA ++AG+  AD  S + A+  AI +  N +
Sbjct: 504 GTAYDIAGKDLADETSMLQAIYTAIDVARNRK 535


>UniRef50_B4S6L0 4-hydroxythreonine-4-phosphate dehydrogenase n=12 Tax=Chlorobiaceae
           RepID=PDXA_PROA2
          Length = 338

 Score =  190 bits (482), Expect = 7e-47,   Method: Compositional matrix adjust.
 Identities = 117/327 (35%), Positives = 170/327 (51%), Gaps = 10/327 (3%)

Query: 10  TPGEPAGIGPDLVVQ-----LAQREWPVEL-VVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           T G+  GIGP+++++     L     P E  +V   A  L   +  LGL + +R      
Sbjct: 7   TIGDIHGIGPEIILKTFDESLRSTGQPEEKPIVIGSAEALLYYSKRLGLSIDIRTIDAPE 66

Query: 64  PAQPQTAGTLTLLPVAL-RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
            A     G L ++ V    +P+  G ++ E G   +  + +A + CL G  AA++T P+H
Sbjct: 67  KAAAYPQGVLPVISVGEPSSPLQPGTISAEAGRLSMLAIEKAANLCLEGRCAAMVTAPIH 126

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLA--TEELRVALATTHLPLRDIADAITPAL 180
           K  +  AG P TGHT+F  +        M+       L VALAT H+ L  + + I    
Sbjct: 127 KEAVARAGYPHTGHTDFLADLCATDNPTMLFRDPVSGLMVALATIHVALHRVPELIRSMD 186

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +    + L+  L++ F I +PRI V GLNPHA +GG MG EE + I+P ++ L A    +
Sbjct: 187 MSAFFSNLNRSLQSDFRIEQPRIAVLGLNPHASDGGVMGREEKEIILPCIDAL-ADRQNI 245

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP  AD  F      N D  +AMYHDQGL   K   F  G+N+TLGLP +RTS DHGT+
Sbjct: 246 EGPFAADGFFGSGKYRNYDVTVAMYHDQGLLPFKVLAFDTGINVTLGLPLVRTSPDHGTS 305

Query: 301 LELAGRGKADVGSFITALNLAIKMIVN 327
            ++AG+G+A   SF  A  LA ++  N
Sbjct: 306 FDIAGQGRASHRSFSEAAKLAWEIAFN 332


>UniRef50_A6TJU5 4-hydroxythreonine-4-phosphate dehydrogenase n=14 Tax=Bacteria
           RepID=A6TJU5_ALKMQ
          Length = 346

 Score =  189 bits (481), Expect = 9e-47,   Method: Compositional matrix adjust.
 Identities = 122/335 (36%), Positives = 173/335 (51%), Gaps = 20/335 (5%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           IT G+P GIGP++  +    +   E+   +V   A +L    A+    L +   S N   
Sbjct: 9   ITMGDPCGIGPEITAKALVHKNVYEVCRPIVVGSAKVLEAAIAICNKDLKVNVVS-NVKE 67

Query: 66  QPQTAGTLTLLP---VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
                GT+ +     V + + V  GQ++   G    E + +  D  + GE    ITGP++
Sbjct: 68  AKFAFGTIDVFDQDHVDVWSLVR-GQVSKIGGQGAYEAIEKVIDLAMKGEIDGTITGPLN 126

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K  +N AG  + GHTE + + +  K   MMLA   LRV   +TH+ LR+  D  T   + 
Sbjct: 127 KEALNIAGYHYGGHTEIYAKLTGTKDYSMMLADGNLRVVHVSTHVSLREACDRCTKERVG 186

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
            VI +     ++  GI  PRI V GLNPH+GE G  G EEID IIP + + +++G+ + G
Sbjct: 187 SVIKLAEEACKS-LGINRPRIAVAGLNPHSGENGLFGREEIDEIIPAIEKAKSEGLDVEG 245

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFG-----------RGVNITLGLPFI 291
           P P DTLF        D V+AMYHDQG   +K  GF             GVNITLGLP I
Sbjct: 246 PEPPDTLFSKALGGQYDIVVAMYHDQGHIPVKVVGFQYNHELKRWNTVSGVNITLGLPII 305

Query: 292 RTSVDHGTALELAGRGKADVGSFITALNLAIKMIV 326
           R+SVDHGTA   AG+G A+  S + A++   ++ V
Sbjct: 306 RSSVDHGTAFGQAGKGTANEESLVNAIDYGARLAV 340


>UniRef50_C9LG48 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Bacteroidales
           RepID=C9LG48_9BACT
          Length = 386

 Score =  189 bits (480), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 123/327 (37%), Positives = 168/327 (51%), Gaps = 8/327 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPN 62
           +V IT G+  G+G +L+ Q        E+   +V     +       LGL    +    +
Sbjct: 27  KVGITHGDTNGVGYELIFQTFGNPTMFEMCTPIVYGSPQIANAHKKALGLQFNYQIIEDS 86

Query: 63  SPAQPQTAGTLTLLP-VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           + A     G L L+  V    PV  GQ     G      L RA      G+   L+T P+
Sbjct: 87  ARA---VDGQLNLIDCVKKDVPVNLGQPDKAAGFAAYCALERATADLREGKIDVLVTAPI 143

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAK-KVVMMLATEELRVALATTHLPLRDIADAITPAL 180
            K  I      FTGHTE+ ++R Q + + +M+L   +LRVAL TTHLPL ++A AIT   
Sbjct: 144 DKFTIQSDDFHFTGHTEYLQDRLQGEYEPLMILMNGQLRVALVTTHLPLSEVAPAITAER 203

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +   + +L   LRT F +  PRI V  LNPH G+ G +G+EE + I PV+ +L  +G  +
Sbjct: 204 VELKLRLLQRSLRTDFLLPMPRIAVLSLNPHCGDKGTIGSEEANIIKPVIEKLVKEGKNV 263

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP PAD  F  +     DAVLAMYHDQGL   K      GVN T GL  +RTS DHG A
Sbjct: 264 FGPYPADGFFGSELHRRFDAVLAMYHDQGLAPFKALAMEEGVNFTAGLSAVRTSPDHGVA 323

Query: 301 LELAGRGKADVGSFITALNLAIKMIVN 327
            ++AG+G A V SF +A+  AI +  N
Sbjct: 324 YDIAGKGVASVASFRSAVYSAIDIYRN 350


>UniRef50_Q89ZK3 4-hydroxythreonine-4-phosphate dehydrogenase n=33 Tax=Bacteroidales
           RepID=PDXA_BACTN
          Length = 364

 Score =  188 bits (478), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 102/239 (42%), Positives = 134/239 (56%), Gaps = 1/239 (0%)

Query: 92  ENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEER-SQAKKVV 150
           E G   +  L RA +    G    ++T P++K  I      F GHTE+ EER     K +
Sbjct: 94  EAGKAALGALERAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGNKSL 153

Query: 151 MMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNP 210
           M+L   + RVAL TTH+P+R+IA  IT  L+ E + I H  L+  FGI  PRI V  LNP
Sbjct: 154 MILMKNDFRVALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNP 213

Query: 211 HAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGL 270
           HAG+GG +G EE + IIP + E+  +G+   GP  AD         + D +LAMYHDQGL
Sbjct: 214 HAGDGGLLGMEEQEIIIPAMKEMEEKGIICYGPYAADGFMGSGNYTHFDGILAMYHDQGL 273

Query: 271 PVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
              K      GVN T GLP +RTS  HGTA ++AG+G A   SF  A+ +AI +  N Q
Sbjct: 274 APFKALAMEDGVNYTAGLPVVRTSPAHGTAYDIAGKGLASEDSFRQAIYVAIDVFRNRQ 332


>UniRef50_P58711 4-hydroxythreonine-4-phosphate dehydrogenase n=64 Tax=root
           RepID=PDXA_ANASP
          Length = 362

 Score =  188 bits (477), Expect = 3e-46,   Method: Compositional matrix adjust.
 Identities = 125/346 (36%), Positives = 184/346 (53%), Gaps = 36/346 (10%)

Query: 6   RVVITPGEPAGIGPDLVVQ-LAQRE--WPVELVVCADATLLTNRAAMLGLPLTLRPYS-P 61
           R+ +T G+P GIG +++++ LA  E     +L V ++  LL      L     L P + P
Sbjct: 19  RLALTVGDPGGIGAEVILKALADLEIGHNYDLTVVSNKNLLQETYKQLSSMENLLPLADP 78

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYV-----VETLARACDGCLNGEFAAL 116
           N          L ++ V +    TA Q+ +  G+          +  A    L G F  +
Sbjct: 79  N---------LLKIIDVTVDRE-TARQINLGTGNAASGAASFAYMDYAIAQTLAGNFDGI 128

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE------LRVALATTHLPLR 170
           +TGP+ K     AG  + G TE   ++S  ++  M+           LR  LATTH+PLR
Sbjct: 129 VTGPIAKSAWKAAGYNYPGQTELLAQKSGVERFGMLFVARSPYTGWTLRALLATTHIPLR 188

Query: 171 DIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVL 230
            +AD +TP LL + + +L   L   FGI   RI + GLNPH+GE G +GTEE+D +IP L
Sbjct: 189 QVADTLTPQLLTQKLDLLVECLEKDFGITSGRIAIAGLNPHSGEQGQLGTEELDWLIPWL 248

Query: 231 NELRAQG--MKLNGPLPADTLF----QPKYLDN-----ADAVLAMYHDQGLPVLKYQGFG 279
              R +    +L+GP+P DT++    Q  Y +      ADA LA+YHDQGL  +K   F 
Sbjct: 249 ESERQKRPHFQLDGPIPPDTMWVKPGQAWYGNAIVQHPADAYLALYHDQGLIPVKLMAFD 308

Query: 280 RGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
           R VN ++GLPF+RTS DHGTA ++AG+G AD  S   A++LA +++
Sbjct: 309 RAVNTSIGLPFVRTSPDHGTAFDIAGQGIADATSMKEAISLAAELV 354


>UniRef50_Q5NMX3 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Zymomonas
           mobilis RepID=PDXA_ZYMMO
          Length = 335

 Score =  187 bits (476), Expect = 3e-46,   Method: Compositional matrix adjust.
 Identities = 113/308 (36%), Positives = 159/308 (51%), Gaps = 4/308 (1%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           + +T G+P+GIGP++V +   R    +++         +  A+  +P+ +    PN  A 
Sbjct: 4   LAVTLGDPSGIGPEIVAKAWSRRKSDQIMPFFAIGSAASIQAVSSIPV-VAITDPNE-AI 61

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
                 L +  +  +  +T G+            L +       G+ +AL+T PV K  +
Sbjct: 62  SIFDQALPVWDIPSKETITPGKPNKAGAEVAFAALEKGVALVKQGQASALVTAPVSKAEL 121

Query: 127 NDAGIPFTGHTEFFEERS--QAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
              G  F G TEF   R    A   VMMLA  +LR    T H+P RD+ + +TP L+   
Sbjct: 122 YQVGFTFPGQTEFVANRCGIAADDAVMMLAGPDLRTVPLTIHIPYRDVLEQLTPKLIISR 181

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL 244
             +   DL+  F I  PR++V GLNPHAGE G +G EEID+I P + +L+A+ + + GP 
Sbjct: 182 ARVTVEDLKRNFAIPSPRLVVAGLNPHAGENGTIGREEIDSIEPAIRQLQAENIDIKGPF 241

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELA 304
            ADTLF P+     D  L   HDQ L  +K   F  GVN TLGLP IRTS DHGTA  LA
Sbjct: 242 AADTLFSPRARATYDVALCPTHDQALIPIKTINFDNGVNTTLGLPIIRTSPDHGTAFPLA 301

Query: 305 GRGKADVG 312
           G+ KAD G
Sbjct: 302 GKNKADEG 309


>UniRef50_B1ZQS3 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Opitutus
           terrae PB90-1 RepID=B1ZQS3_OPITP
          Length = 336

 Score =  186 bits (473), Expect = 8e-46,   Method: Compositional matrix adjust.
 Identities = 126/349 (36%), Positives = 173/349 (49%), Gaps = 50/349 (14%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPY 59
            T ++ +T G+PAG+GP+++         V    +V+     L +  A +  + + L  +
Sbjct: 6   NTTKLALTCGDPAGVGPEVIASWLASPAAVSQDVVVIGPPRWLESLPAGVRKIAVGLEDF 65

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
           S  +P  P   G L    VA  A                  + RA +GC  GEF  ++TG
Sbjct: 66  S-ATPGAPDADGAL----VAWAA------------------IERAAEGCRQGEFCGVVTG 102

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P+ K  +   G PF G TEFF  R   + V M  A   LRV LAT H+PL ++   + P 
Sbjct: 103 PISKERLAKIGYPFPGQTEFFAARWGGEPV-MAFAGGRLRVVLATWHIPLHEVGGRLGPH 161

Query: 180 LLHEVI-------------------AILHHDLRTKFGIA----EPRILVCGLNPHAGEGG 216
           LLH                      AI  + +  ++G      +PRI VCGLNPHAGEGG
Sbjct: 162 LLHRAAQAATEIARIDCRAGAPVHAAIGANAVNDRWGQGIPPDKPRIGVCGLNPHAGEGG 221

Query: 217 HMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQ 276
            +G EE D I P L+ LR +   L+   PADT+F        D V+A+YHDQGL  LK  
Sbjct: 222 LLGYEERDFIDPALDHLRTEFAGLSRCQPADTIFARALQGEFDVVIALYHDQGLAPLKTI 281

Query: 277 GFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
            F   VN+TLGLPF+RTS DHGT   +AG+G A   SF  A+ +A ++I
Sbjct: 282 DFDESVNVTLGLPFVRTSPDHGTGFGIAGKGVARATSFANAVTVARQLI 330


>UniRef50_Q30Z16 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Desulfovibrionales RepID=Q30Z16_DESDG
          Length = 365

 Score =  186 bits (473), Expect = 8e-46,   Method: Compositional matrix adjust.
 Identities = 105/244 (43%), Positives = 135/244 (55%), Gaps = 3/244 (1%)

Query: 84  VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEER 143
           VT G+   + G      L  AC    +G    ++T P+HK ++  AG  F GHTEF    
Sbjct: 113 VTPGKATADGGRAAGLALQEACSMLNDGAATGVVTLPLHKAMLQQAGFDFPGHTEFLARH 172

Query: 144 S--QAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEP 201
           +  + + V M L  + LRV+L TTH  LRD+   +T   +   IA+    +R   G    
Sbjct: 173 AGLRDEDVCMHLCGDVLRVSLVTTHPALRDVPRLVTRQRVARCIALTVEFVRA-LGAGHK 231

Query: 202 RILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAV 261
            + VCGLNPHAGE G +G E+   I P + E +  G+   GP PADT+F         AV
Sbjct: 232 PVAVCGLNPHAGESGKIGVEDESIIAPAVREAKRMGLNAEGPYPADTIFYRAAQGEFAAV 291

Query: 262 LAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLA 321
           LAMYHDQGL  LK   F   VN+TLGLPF+RTSVDHGT  ++AGR  AD GSF +AL LA
Sbjct: 292 LAMYHDQGLAPLKLLHFSDAVNVTLGLPFVRTSVDHGTGFDIAGRNTADTGSFESALRLA 351

Query: 322 IKMI 325
             M 
Sbjct: 352 ADMC 355


>UniRef50_C6XHX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Liberibacter asiaticus str. psy62 RepID=C6XHX7_LIBAP
          Length = 343

 Score =  186 bits (472), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 110/326 (33%), Positives = 168/326 (51%), Gaps = 9/326 (2%)

Query: 7   VVITPGEPAGIGPDLVVQ-LAQREWPV--ELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           +++T G+PAGIGPD+ ++  A R+       +   D  +L  RA  L L + L      +
Sbjct: 7   LILTQGDPAGIGPDISLKAWASRQITAIPPFIYIGDVDVLNARAKQLNLSVPLYETDCKN 66

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A       L ++     A +  G    +     +  + +A    L+G+  A++T P+ K
Sbjct: 67  -AVSIFKKALPIISSPCGAKIVTGTPNPQTASSTIANIEKAVSLTLSGQALAIVTNPIAK 125

Query: 124 GVINDAGIPFTGHTEFFEERSQAK-----KVVMMLATEELRVALATTHLPLRDIADAITP 178
            ++      F GHTEF  E ++       K VMML+  +LR    T H+P+ DI   ++ 
Sbjct: 126 FLLYQEKFKFPGHTEFLAELAKKNTGITFKPVMMLSGPQLRTVPVTIHIPIADICRILST 185

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + E    +++ ++  FGI  PRI + GLNPHAGE   +G EE + IIP +  LR    
Sbjct: 186 KRIIETSDTVYNAMKKYFGINNPRIAISGLNPHAGENATIGIEEKNIIIPAITYLRNDNK 245

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            + GPLPAD++F        D  + MYHDQ L  +K   F + VNITLGLPF+RTS DHG
Sbjct: 246 NIIGPLPADSMFHHSARQCYDVAICMYHDQALIPIKTLDFNQTVNITLGLPFVRTSPDHG 305

Query: 299 TALELAGRGKADVGSFITALNLAIKM 324
           TA ++AG       S ++AL +A ++
Sbjct: 306 TAFDIAGSSLTQEESLVSALKIAAQL 331


>UniRef50_B7UKV9 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=15
           Tax=Enterobacteriaceae RepID=B7UKV9_ECO27
          Length = 328

 Score =  185 bits (470), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 119/324 (36%), Positives = 176/324 (54%), Gaps = 9/324 (2%)

Query: 7   VVITPGEPAGIGPDLVVQLAQRE----WPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           + +T G+PAGIGP+++++          PV +V C   TL    A  +     LR     
Sbjct: 5   IAVTMGDPAGIGPEIIIKSLSEAGLAGTPVVVVGCVR-TLRRIMAMNITPQAELRVIQKV 63

Query: 63  SPAQPQTAGTLTLL--PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
             A     G + ++  P+A    +T G +    G      + RA    L+GE  A+ T P
Sbjct: 64  CDAH-FAPGVINVMDEPLANPDALTPGVVQAAAGDLAYRCIKRATALALSGEVKAIATAP 122

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           ++K  ++  G  + GHTE     + +K+  M+L T++L+V   +TH+ LR   D +    
Sbjct: 123 LNKEALHLGGHNYPGHTELLAHLTGSKEYAMVLYTDKLKVIHISTHISLRKFLDTLNGER 182

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +  VI + +H L+ + GI  PRI V G+NPHAGE G  GTEEI+ I P +  ++A+ + +
Sbjct: 183 VKTVIRVANHFLK-RVGIERPRIAVAGVNPHAGEHGLFGTEEIEIIAPAIEAMQAEDIDV 241

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP P DT+F   +    D V+AMYHDQG   LK  GF  GVNIT GLPFIRTS DHGTA
Sbjct: 242 TGPCPPDTVFMQCHEGLFDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTA 301

Query: 301 LELAGRGKADVGSFITALNLAIKM 324
            ++A  GKA   S   ++ LA+++
Sbjct: 302 FDIAWTGKAKSESMAVSIQLAMQI 325


>UniRef50_A0JTQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=9 Tax=Bacteria
           RepID=A0JTQ9_ARTS2
          Length = 792

 Score =  185 bits (470), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 127/323 (39%), Positives = 176/323 (54%), Gaps = 7/323 (2%)

Query: 7   VVITPGEPAGIGPDLVVQLA---QREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           V +T G+ AG+GP++VV      Q       VV  DA  L   A +LG+   +       
Sbjct: 464 VAVTMGDGAGVGPEVVVAAVLDPQSNKECRPVVIGDALRLRQAADVLGIEADIHTIEKVE 523

Query: 64  PAQPQTAGTLTLLPVALR-APVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
            A   T G + ++ +AL    +  GQL+   GH   E +  A +  + G   A+ T P++
Sbjct: 524 DAV-FTPGRVNVIDLALLPEDLPWGQLSPVAGHAAYEYIRVASELAMAGTVQAICTAPLN 582

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K  ++ AG  F GHTE   + +  ++V MML+T ++RV   TTH+ L D    I P L+ 
Sbjct: 583 KEALHAAGHIFPGHTELLAQLTGTEEVSMMLSTPKIRVIHVTTHIGLMDAIRKINPDLVE 642

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRAQGMKLN 241
             I   H  L  + GI  P+I VC +NPHAGE G  G  EE + I P +   +A G+ + 
Sbjct: 643 RTIRRGHEAL-VRAGIPNPKIGVCAINPHAGENGLFGQGEEAEKIEPGVKAAQAAGIDVT 701

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GPLPADTLF      + D V+AMYHDQG   +K  G   GVNIT+GLP IRTSVDHGTA 
Sbjct: 702 GPLPADTLFFLAGRGDYDLVVAMYHDQGHGPVKVLGIEAGVNITVGLPVIRTSVDHGTAF 761

Query: 302 ELAGRGKADVGSFITALNLAIKM 324
           ++AG+  AD  S + AL+ A +M
Sbjct: 762 DIAGKAIADPRSMVEALHQAAEM 784


>UniRef50_B5JFI3 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JFI3_9BACT
          Length = 303

 Score =  185 bits (469), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 119/330 (36%), Positives = 176/330 (53%), Gaps = 37/330 (11%)

Query: 5   QRVVITPGEPAGIGPDLVVQ-LAQREW-PVELVVCADA----TLLTNRAAML-GLPLTLR 57
           +++ IT G+P+G+GP+L+   L  R++   E VV  +      L ++R  ++ G+ L  R
Sbjct: 2   RKIAITCGDPSGLGPELIENCLDTRDYGDAEFVVFGNGPWVERLESDRGTIVSGVSLCER 61

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
            ++P  P +P  A        A                            C++GE  A++
Sbjct: 62  GFTPGIP-EPDGARLAMAAMEAAAKA------------------------CIDGECHAVV 96

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           TGP+ K +  + G  F G TEFF +R   K   M    E L++ LAT H+PLR +A+++T
Sbjct: 97  TGPISKSLCAEVGYTFPGQTEFFADRWGGKPS-MAFVGERLKLCLATWHIPLRQVAESLT 155

Query: 178 PALL-HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
             +  H V + +   L  + GIA+P+ILVCGLNPHAGE G +G EEI+   P +  LR Q
Sbjct: 156 EKVFKHGVRSAVQ--LGQRSGIAKPKILVCGLNPHAGESGLLGREEIELFNPWIESLRGQ 213

Query: 237 -GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
              ++   +P DT F      + D V+AMYHDQGL   K   F  GVN++LGL ++R S 
Sbjct: 214 LTAEIEDCVPGDTAFARAIKGDGDVVVAMYHDQGLAPFKAVDFDSGVNVSLGLKYLRVSP 273

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMI 325
           DHGT  +LAG+G A+ GS   A+ LA  M+
Sbjct: 274 DHGTGFDLAGKGLANAGSMHHAIRLACNMV 303


>UniRef50_Q02C14 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Solibacter usitatus Ellin6076 RepID=Q02C14_SOLUE
          Length = 339

 Score =  184 bits (467), Expect = 4e-45,   Method: Compositional matrix adjust.
 Identities = 115/315 (36%), Positives = 163/315 (51%), Gaps = 27/315 (8%)

Query: 7   VVITPGEPAGIGPDLVVQLAQR-------EWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
           + +T G+PAGIGP++V+Q            W    +V  D  +L   + + G+ L  + +
Sbjct: 12  IALTMGDPAGIGPEIVLQAVADPDLAPLARW----IVVGDGEVLEQASRITGIGLQAKLH 67

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
              + A                     G+L    G   VE +  A + CL GE  A++T 
Sbjct: 68  DARALADIDQ--------------FMFGRLDARCGIAAVEYVRIATEMCLAGEAEAIVTA 113

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P++K  +  +G PFTGHTE+  E   A +  M+L +E L     TTH+ LR   +  T  
Sbjct: 114 PLNKEAVTLSGRPFTGHTEYIAELCGATESRMLLCSERLSTIHVTTHVALRTACETGTAR 173

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
           +L  +   L +D     G +EPRI VCGLNPHAGE G  G E+   I+P +   RA+G+ 
Sbjct: 174 ILRTIE--LGNDAMKLLGKSEPRIAVCGLNPHAGEHGLFGDEDQRVIVPAVEAARAKGIA 231

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
            +GP   DT+F        D V+AMYHDQG   +K   F   VNI+LG+P IRTSVDHGT
Sbjct: 232 CSGPHAPDTVFLQAVRGAYDLVVAMYHDQGHIPMKLIDFEGTVNISLGIPIIRTSVDHGT 291

Query: 300 ALELAGRGKADVGSF 314
           A ++AG+G+AD  S 
Sbjct: 292 AFDIAGKGRADARSI 306


>UniRef50_B2U6L2 4-hydroxythreonine-4-phosphate dehydrogenase n=8 Tax=Proteobacteria
           RepID=B2U6L2_RALPJ
          Length = 770

 Score =  184 bits (467), Expect = 4e-45,   Method: Compositional matrix adjust.
 Identities = 125/322 (38%), Positives = 171/322 (53%), Gaps = 9/322 (2%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           IT G+ AG+GP+++++        E    +V  D   L + A   G  L +R  S   PA
Sbjct: 439 ITMGDAAGVGPEIIMKALTHRAVYEQCRPLVIGDTARLRDAAQRTGAALEVR--SIERPA 496

Query: 66  QPQ-TAGTLTLLPVAL-RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
                 G +  + + L  A +  G+L+   G    + +AR  +    GE  A+ T P++K
Sbjct: 497 DAAFRYGVVDCIDLGLIPADLPYGKLSPIAGDAAYQYIARTVELTSAGELDAICTAPLNK 556

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             ++  G  F GHTE     +   +V MML    LRV   TTH+ L D    I P L+  
Sbjct: 557 EALHAGGHIFPGHTEMLAHLTGIDEVSMMLVAPNLRVIHVTTHIGLLDAIRRIEPGLVQR 616

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMG-TEEIDTIIPVLNELRAQGMKLNG 242
            I   H  L  + GI  PRI VCG+NPHAGE G  G  EE   IIP +  L+A+G ++ G
Sbjct: 617 TIERAHATL-VRAGIENPRIGVCGINPHAGENGLFGHGEEEQKIIPAVQVLQARGWRVEG 675

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
           PLPADTLF      + D V+AMYHDQG   +K  G   GVN+T+GLP IRTSVDHGTA +
Sbjct: 676 PLPADTLFFRAGRGDFDVVVAMYHDQGHGPVKVMGLEAGVNVTVGLPVIRTSVDHGTAFD 735

Query: 303 LAGRGKADVGSFITALNLAIKM 324
           +AG+G AD  S + A   A ++
Sbjct: 736 IAGKGIADERSMLEAFRQACEL 757


>UniRef50_B1B883 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Bacteria
           RepID=B1B883_CLOBO
          Length = 323

 Score =  184 bits (466), Expect = 5e-45,   Method: Compositional matrix adjust.
 Identities = 104/315 (33%), Positives = 171/315 (54%), Gaps = 4/315 (1%)

Query: 9   ITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           IT G+PAGIG +++++   +  E+  + ++     ++     +L +   +      +   
Sbjct: 6   ITMGDPAGIGAEIILKALDKYDEYRKKSIIFGSKDVMEFYRDILNVNAHINIIEDINEFN 65

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
                 +  + +++   +  GQ++   G    + +  +    LN +  A++T P++K  +
Sbjct: 66  DSCINLVNCVDISMD-DIKIGQVSGRCGDAAYKYVEESIKWALNKKIKAVVTTPLNKKAL 124

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIA 186
           +     F GHTE F + +  KK  M+L +++L+V   +TH+ L +    +    + +VI 
Sbjct: 125 HLGNHNFDGHTEIFAKLTGTKKYAMLLWSDDLKVIHVSTHISLFNACKNVKKERIFDVIN 184

Query: 187 ILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPA 246
            L +D   K G+  PRI V GLNPHAGE G  GTEEI+ I P + E R +G+ ++GP+P 
Sbjct: 185 -LANDTFKKMGVKNPRIAVAGLNPHAGEDGIFGTEEINEIGPAVEEARKRGINVHGPIPP 243

Query: 247 DTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGR 306
           D +F   Y    D V+AMYHDQG   +K   F  GVNIT+GLP IRTSVDHGTA ++AG 
Sbjct: 244 DIVFLKAYNKEYDIVVAMYHDQGHIPMKLLEFDSGVNITVGLPIIRTSVDHGTAFDIAGN 303

Query: 307 GKADVGSFITALNLA 321
             A+  S I A+ ++
Sbjct: 304 LVANDKSLIQAIKVS 318


>UniRef50_B6BUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=beta
           proteobacterium KB13 RepID=B6BUU4_9PROT
          Length = 310

 Score =  183 bits (465), Expect = 6e-45,   Method: Compositional matrix adjust.
 Identities = 109/331 (32%), Positives = 169/331 (51%), Gaps = 30/331 (9%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLP----LTL 56
           M   + + ++ G+P GIG DL   L ++     + +  D   L +RA +LG+       +
Sbjct: 1   MNHIKTLAVSAGDPDGIGYDLCALLFKKNLNYHVDIYGDKEALLSRAKLLGIKNLHNEKI 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
           + Y   +  Q +    L                       V+E++  A   C+  +  AL
Sbjct: 61  KIYDVKNNKQIKNKREL-----------------------VLESIKSATKSCIQKKSIAL 97

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKK--VVMMLATEELRVALATTHLPLRDIAD 174
           +T PV+K  ++ +   FTGHTE+  E  +A+   ++  +  +++ VA  TTH+ L +   
Sbjct: 98  VTLPVNKEKLSTSKNLFTGHTEYIAELLKARNEPIMTFIGNKKIIVATNTTHMSLLNAIK 157

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +    L   + +LH  ++ +  I  P+ILV GLNPHAGE    G EE   IIP +N+L+
Sbjct: 158 NVEKNNLINKLQLLHSCIKNQLKIKYPKILVTGLNPHAGENNLFGNEESKHIIPAINKLK 217

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
              + L+GP+PADT      +   D +  MYHDQ L   K   F  GVN+TLGLP IRTS
Sbjct: 218 ELDIHLDGPVPADTALLKNNMRKYDCIYYMYHDQALCAFKTLFFDTGVNLTLGLPIIRTS 277

Query: 295 VDHGTALELAGRG-KADVGSFITALNLAIKM 324
           VDHGTA EL G+  +  + SF+ AL++A K+
Sbjct: 278 VDHGTAEELVGKKERISIKSFLNALDIAEKL 308


>UniRef50_D2R6V9 4-hydroxythreonine-4-phosphate dehydrogenase n=7 Tax=Bacteria
           RepID=D2R6V9_9PLAN
          Length = 344

 Score =  182 bits (463), Expect = 1e-44,   Method: Compositional matrix adjust.
 Identities = 122/335 (36%), Positives = 185/335 (55%), Gaps = 16/335 (4%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLP-----LT 55
           ++RV IT G+ AG+GP++ ++L      V     +V  DA +LT  +A  G+      ++
Sbjct: 14  SKRVAITMGDAAGVGPEICLRLLADPQIVRECIPIVIGDAEVLTRVSAATGISWQADVIS 73

Query: 56  LRPY--SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEF 113
           L  +  +P++  +P    T+  LP    A V  G ++   G    E ++ A D  +  + 
Sbjct: 74  LGEWNRAPSAIVRP----TVVHLPSLDAASVVPGSISAMTGRASYEYISAAIDAVIAQDV 129

Query: 114 AALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIA 173
            A+ TGP+ K  ++ AG+ F GHTE F  R+ +++  MM  +E +     T H+   ++ 
Sbjct: 130 CAVTTGPISKEALHAAGLKFPGHTEIFASRTSSQRSCMMQYSEIITCTFVTVHVGYYEVP 189

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNE 232
           + +T   + +VI +    L    G A P+++VCGLNPHAGE G  G  EE   IIP +  
Sbjct: 190 ELLTTERIGDVIDLTADALLKIRGRA-PKMVVCGLNPHAGEHGLFGNREEERVIIPAIAA 248

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
            RA+G +++GPLP DT F P      DA + MYHDQG   +K   F + VN TLGLP IR
Sbjct: 249 ARARGHQIDGPLPPDTCFTPAKRAITDAFICMYHDQGHIPVKALAFEQAVNTTLGLPVIR 308

Query: 293 TSVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           TSVDHGTA ++A +GKAD  S   A+ LA+++  N
Sbjct: 309 TSVDHGTACDIAWQGKADPSSLFAAVRLAVRLADN 343


>UniRef50_Q6AB12 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Actinomycetales RepID=PDXA_PROAC
          Length = 346

 Score =  180 bits (457), Expect = 5e-44,   Method: Compositional matrix adjust.
 Identities = 112/329 (34%), Positives = 170/329 (51%), Gaps = 12/329 (3%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLR 57
           M KT  + IT G+PAGIGP++ VQ       +     +V  D  +++   ++ GL  T+R
Sbjct: 1   MPKTPLLGITEGDPAGIGPEITVQAIHNMADDRSFIPIVYGDPAIISRACSVTGLSETVR 60

Query: 58  PYSPNSPAQPQTA--GTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
             +     +P++     +    V     +  G +    G   + ++  A D  L+G+   
Sbjct: 61  RVTSEEHIEPESNVINVVDTGTVPHADSIEWGSVQELAGRAAIASIEAATDAALSGKTDG 120

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           ++T P++K  I   G  F GHTE             M     L++  AT H+ LR+  D+
Sbjct: 121 VVTSPINKEAIWKTGSEFLGHTEMLGSLCGTPDTDTMFVVSGLKIFFATRHMSLREAVDS 180

Query: 176 ITPALL-HEVIAILHHDLRT--KFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
           I   L+ HE+    H  LR    FG   P++ V  LNPHAGEGGH GTEEI+ + P +  
Sbjct: 181 IRRDLIDHEI----HKALRALKVFGCNSPKLAVAALNPHAGEGGHFGTEEIEVLRPAVKS 236

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
             A+G  + GP+PAD++F    +   D VL++YHDQG    K   F   V++T GLP +R
Sbjct: 237 ACAEGHNVVGPVPADSVFHKGVIREYDGVLSLYHDQGHIASKTLDFDGTVSVTAGLPILR 296

Query: 293 TSVDHGTALELAGRGKADVGSFITALNLA 321
           TSVDHGTA ++AG+G A   +  +AL++A
Sbjct: 297 TSVDHGTAFDIAGQGAASPMTMQSALHVA 325


>UniRef50_A6H263 4-hydroxythreonine-4-phosphate dehydrogenase n=14 Tax=Bacteroidetes
           RepID=A6H263_FLAPJ
          Length = 349

 Score =  179 bits (455), Expect = 9e-44,   Method: Compositional matrix adjust.
 Identities = 108/323 (33%), Positives = 167/323 (51%), Gaps = 8/323 (2%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           V I+ G+  GIG +++++  +    +EL   ++ A+  +L+     L L     P     
Sbjct: 10  VGISIGDLNGIGSEVILKSFEDSRMLELCTPIIFANVKILSFLKKELRLE---APLHGID 66

Query: 64  PAQPQTAGTLTLLPVALRA-PVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
                  G + +L V      +  GQL    G Y +++   A +    G    L+T P+ 
Sbjct: 67  RLDQMVIGKINVLNVWREGVNINYGQLDNAVGKYAIKSFVAATNALKEGGIDVLVTAPIS 126

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K  I      F GHT++ ++  +   ++ M+  + LRV L T H+PL ++A  +T  L+ 
Sbjct: 127 KANIQTEDFKFPGHTDYLDQELEGDALMFMIQ-DNLRVGLLTDHVPLSEVAKHLTEELIR 185

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
           + I  ++  L   FGI +P+I V GLNPH+ + G +G EE   I P L ++  +G  + G
Sbjct: 186 KKIKTINKSLIQDFGIRKPKIAVLGLNPHSSDNGVIGNEEDKIIKPTLKKIFDEGTLVFG 245

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
           P  AD  F     +N DAV+A YHDQGL   K   FG+GVN T GL  +RTS DHGTA E
Sbjct: 246 PFSADGFFGNNQYENYDAVIATYHDQGLIPFKTLSFGKGVNYTAGLNKVRTSPDHGTAFE 305

Query: 303 LAGRGKADVGSFITALNLAIKMI 325
           +AG+G A+  SF+ A+  AI + 
Sbjct: 306 IAGKGIANNNSFLEAIYTAIDIF 328


>UniRef50_C0A8L4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Opitutaceae
           bacterium TAV2 RepID=C0A8L4_9BACT
          Length = 360

 Score =  179 bits (454), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 125/355 (35%), Positives = 170/355 (47%), Gaps = 64/355 (18%)

Query: 7   VVITPGEPAGIGPDLV-VQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN--- 62
           +  T G+PAG+GP+++   LAQ   P E     D  ++  R  +  LP ++         
Sbjct: 24  LAFTCGDPAGVGPEIIAAWLAQH--PDEY---RDVAVIGPRRWLDSLPASIAKIVVGGND 78

Query: 63  ---SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
              +P QP  AG +                         + + RA  GCLNGEF+ ++TG
Sbjct: 79  FVVTPGQPTEAGAVIAW----------------------DAMERAAAGCLNGEFSGVVTG 116

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKV---------------------------VMM 152
           P+ K  +   G  + G TEFF +R ++                              VM 
Sbjct: 117 PISKAWLARVGYKYPGQTEFFADRWRSASTIGQGGGGDRGNGGSGGRNGGNGKNGQPVMA 176

Query: 153 LATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAE--PRILVCGLNP 210
            A   L V L T H+PLR +A  +T A     I     +L   +G     PRI VCGLNP
Sbjct: 177 FAGGRLPVGLHTWHIPLRAVAAELTLANFTRSIRAA-DELARVYGCEREHPRIGVCGLNP 235

Query: 211 HAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGL 270
           HAGE G +G +E D I P+L+ LRAQ   L+   P DTLF  +     D V+A+YHDQGL
Sbjct: 236 HAGEEGLLGNQERDVIDPILDTLRAQFHGLSRSEPGDTLFGRQLRGEFDVVVALYHDQGL 295

Query: 271 PVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
             LK   F   VNITLGL  +RTS DHGTA  +AG+GKA + SF  A+ +A ++I
Sbjct: 296 APLKVIDFDESVNITLGLAHVRTSPDHGTAFGIAGQGKASIRSFANAVTVARRLI 350


>UniRef50_Q2N8X0 4-hydroxythreonine-4-phosphate dehydrogenase n=5
           Tax=Sphingomonadales RepID=PDXA_ERYLH
          Length = 336

 Score =  179 bits (454), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 121/329 (36%), Positives = 165/329 (50%), Gaps = 11/329 (3%)

Query: 1   MVKTQR-VVITPGEPAGIGPDLVVQLAQREWPVELV---VCADATLLTNRAAMLGLPLTL 56
           M + QR + ++ G+PAGIGP+++V   +      L    V   A +L +    LG+P  +
Sbjct: 1   MGEPQRPLAVSLGDPAGIGPEIIVHAWRMRDSANLAPFAVAGGANVLRSATEALGVPCPI 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPV--ALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFA 114
           +     + A    +  L  LPV   L      G          +++L  A      G  +
Sbjct: 61  QEIDDIAEAN---SAFLEALPVIKGLDGAYLPGAPDPIGAKLALKSLEMATRLATAGHAS 117

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERS--QAKKVVMMLATEELRVALATTHLPLRDI 172
            ++T P+ KG++   G    G TEF            VMMLA   LR    T H PL ++
Sbjct: 118 GVVTAPIAKGLLEQVGFTHPGQTEFLAAACGLPEDASVMMLAGPSLRAVPLTVHCPLAEV 177

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
              ++  L+ E   I+   L+  FGI  PR+ V GLNPHAGE G  G EE D I P + E
Sbjct: 178 PGLLSIGLIVERGRIVASALQRDFGIERPRLAVTGLNPHAGEDGKFGNEEQDVIAPAIAE 237

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
           L A G+   GP PAD LF P      DA L MYHDQ L  +K   F +GVN+TLGLP +R
Sbjct: 238 LLADGITATGPHPADALFSPHSRAGFDAALCMYHDQALIPVKALDFDQGVNVTLGLPIVR 297

Query: 293 TSVDHGTALELAGRGKADVGSFITALNLA 321
           TS DHGTA ++AGRG A  G+ + AL +A
Sbjct: 298 TSPDHGTAFDIAGRGTAHPGAMVFALLMA 326


>UniRef50_A0NP49 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Rhodobacteraceae RepID=A0NP49_9RHOB
          Length = 340

 Score =  178 bits (451), Expect = 2e-43,   Method: Compositional matrix adjust.
 Identities = 107/324 (33%), Positives = 170/324 (52%), Gaps = 6/324 (1%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           R+V+T G+PAGIG +LV +L   E   +   +++  D   L N   + G+       S  
Sbjct: 7   RLVLTLGDPAGIGSELVARLLADEEARQAAAILILGDEDELKNGMDIAGVRFEYEKVSEA 66

Query: 63  S-PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           + P+Q     +   +  A        +++ E G + +ETL +  D   +G+  AL+  P+
Sbjct: 67  ALPSQATDVPSFFQVGTAPEGGWKRAEVSAEGGAHCLETLGKGVDLVRSGKADALVFAPL 126

Query: 122 HKGVINDAGIPFTGHTEFFEER-SQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           +K  ++ AG+  +    +F +R      V  +   + L  +  T+H+ LRD+AD IT   
Sbjct: 127 NKASLHSAGMSQSDELHWFADRLGHNGSVSELNVMDGLWTSRVTSHIALRDVADLITEDK 186

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           + E   ++H  L+   G   PRI VCGLNPH G+ G+ GTEEI+ I P +   +A G+ +
Sbjct: 187 IIEAARLIHSALKDA-GFESPRIGVCGLNPHNGDNGNFGTEEIEIITPAVERAKALGLPV 245

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP P+DT+F        DA++ +YHDQG   +K  GF +GV +  GLP   T+  HGTA
Sbjct: 246 EGPYPSDTIFLKAVAKELDAIVTLYHDQGQIAIKLLGFWQGVTVQGGLPIPITTPAHGTA 305

Query: 301 LELAGRGKADVGSFITALNLAIKM 324
            ++ G+G A+VG    A N+A  M
Sbjct: 306 FDIRGKGTANVGPMRNAWNIACAM 329


>UniRef50_D0LQB4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Haliangium
           ochraceum DSM 14365 RepID=D0LQB4_HALO1
          Length = 338

 Score =  178 bits (451), Expect = 3e-43,   Method: Compositional matrix adjust.
 Identities = 121/334 (36%), Positives = 169/334 (50%), Gaps = 21/334 (6%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M  + ++ IT G+PAGIGP+++             V   +  L  R  + G     RP  
Sbjct: 1   MTTSDKIGITLGDPAGIGPEIIAA----------AVADASAELRGRLTLFGD----RPIL 46

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQL-----AVENGHYVVETLARACDGCLNGEFAA 115
             + AQ   +   + + V  R  ++A Q         +G   V  L  A      G    
Sbjct: 47  ERAFAQITGSRIPSDIQVVDRGLLSADQAIPGSPTGASGAAQVAYLEAAVSAARRGTIGG 106

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           L+T P++K     AG  F GHTEF  ER  A+ V MM A   L+V LAT HL L ++  A
Sbjct: 107 LVTAPINKRSARQAGFSFPGHTEFLAERLGAQHVAMMFAGPRLKVVLATVHLALSEVPGA 166

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           +T   +     +    +   FGIA  R+ V GLNPHAGE G  G EE++ I P + E R 
Sbjct: 167 LTRDGIVRTAKLAAEAVSRDFGIASARVGVLGLNPHAGEHGLFGREELEIIGPAIEECRR 226

Query: 236 Q--GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
           Q  G +++GPL  D  F+       D ++AMYHDQGL  +K   F + VN+TLGLP +RT
Sbjct: 227 QIDGAQVDGPLIPDAAFRQADGGAYDVLVAMYHDQGLIPVKLLDFEQAVNVTLGLPIVRT 286

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           S DHG A ++AG GKA   SF+ AL+LA ++  +
Sbjct: 287 SPDHGVAYDIAGTGKARPQSFMAALSLAARLTTH 320


>UniRef50_Q7UMZ2 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Rhodopirellula
           baltica RepID=PDXA_RHOBA
          Length = 351

 Score =  177 bits (449), Expect = 4e-43,   Method: Compositional matrix adjust.
 Identities = 97/249 (38%), Positives = 136/249 (54%), Gaps = 11/249 (4%)

Query: 85  TAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERS 144
           T G+ +   G    +++  A D  ++G   A++TGP+ K   + AGI F GHTE   +R+
Sbjct: 102 TPGKFSAATGRASYQSVTDAIDAAVSGHVDAIVTGPIQKEAWHQAGIDFPGHTELLADRA 161

Query: 145 ------QAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAI----LHHDLRT 194
                 +   V MMLA++ +   L T H+PL D+A  +    L   I +    +    + 
Sbjct: 162 GRAVQGEPADVRMMLASDTIACVLETIHIPLADVASQLNTESLVRTINLAGETVQRRNQN 221

Query: 195 KFGIAEPRILVCGLNPHAGEGGHMGTEEIDTII-PVLNELRAQGMKLNGPLPADTLFQPK 253
           +  +  PRI VCGLNPHAGE G    +E + II P +   R  G  + GPL  DT F P 
Sbjct: 222 RGSLLPPRIAVCGLNPHAGENGLFSHQEEEQIILPAIEAARQSGWTIEGPLSPDTAFTPA 281

Query: 254 YLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGS 313
             +  D  + MYHDQGL  LK   F   VN+TLGLP IRTSVDHGTA++LA +GKA + S
Sbjct: 282 MRERIDIYVCMYHDQGLIPLKALSFDDAVNVTLGLPIIRTSVDHGTAMDLAWQGKASINS 341

Query: 314 FITALNLAI 322
            + A+  A+
Sbjct: 342 MLAAIRWAV 350


>UniRef50_C1A9L0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Gemmatimonas
           aurantiaca T-27 RepID=C1A9L0_GEMAT
          Length = 309

 Score =  177 bits (449), Expect = 5e-43,   Method: Compositional matrix adjust.
 Identities = 120/317 (37%), Positives = 170/317 (53%), Gaps = 29/317 (9%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQ 68
           IT G+P GIGP++V + A R+  VE  + A   ++      + + + L P+ P+  AQ  
Sbjct: 14  ITLGDPRGIGPEIVGK-ALRDSRVE-ALGAFWQVIGPSGTGVPVDVDLGPWQPSGDAQAD 71

Query: 69  TAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVIND 128
            A              T G+LA   G  V    A A  G ++G    ++T P+ K  +  
Sbjct: 72  LA--------------TGGRLA---GLAVERATAMAQRGTIDG----MVTAPLDKAALKA 110

Query: 129 AGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAIL 188
            G  + GHTE     +      MMLA++ LRV LATTH+ LRD+  ++T A + +     
Sbjct: 111 GGYDYPGHTEMLAALTGVP-TTMMLASDRLRVVLATTHIALRDVPVSLTAAAIRQAAQAT 169

Query: 189 HHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADT 248
              LR   GI  PRI++C LNPHAG+ G  G E+   + P+  EL      L+GPLPADT
Sbjct: 170 EAGLRADLGIPVPRIVLCALNPHAGDHGRFGDEDDTLLAPLAREL-----GLHGPLPADT 224

Query: 249 LFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGK 308
           +F        DAV+A YHD G+  +K   FG  VNITLGLPF+RTS DHGTA+++AG+G 
Sbjct: 225 VFVRALRGEFDAVIAPYHDVGMTAIKVASFGSAVNITLGLPFVRTSPDHGTAIDIAGQGV 284

Query: 309 ADVGSFITALNLAIKMI 325
           A   S I A+  A+ ++
Sbjct: 285 ASAESLIQAMTTAVGLV 301


>UniRef50_B5YL57 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Thermodesulfovibrio yellowstonii DSM 11347
           RepID=B5YL57_THEYD
          Length = 316

 Score =  177 bits (448), Expect = 6e-43,   Method: Compositional matrix adjust.
 Identities = 113/325 (34%), Positives = 175/325 (53%), Gaps = 15/325 (4%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSP 61
           +R+ IT G+PAG+GP+++V+   +E   ++   +V  D  ++     ++G+   L     
Sbjct: 4   KRIAITMGDPAGVGPEIIVKAFAQEDIYKICNPIVIGDKAVIKELIKVIGMDFDL----- 58

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
                      L L  +   + +  G  + E+G      + +A +    G   A++T P+
Sbjct: 59  ------DNIEMLNLNEIKNPSKLLKGTPSEESGRACFSYIRKAVELYRLGVVQAIVTCPI 112

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
            K  +  AG+P+ GHT+   E +  +   M   +E L+V L T H+PL+++   I    +
Sbjct: 113 TKVALKMAGLPWLGHTDMLAELTDTEDYAMAFYSEHLKVILVTIHVPLKEVPYLIKKENV 172

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
            + I            I  PRI VCGLNPHAGE G +G EEI+ I P + E +A G+ ++
Sbjct: 173 IKSICFAKKACDM-LRIENPRIAVCGLNPHAGEEGIIGREEIEEITPAIKETKALGINVS 231

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP P+D+LF   Y    D V+AMYHDQ L   K   F +GVN T+GLPFIRTS DHGTA 
Sbjct: 232 GPYPSDSLFWRAYKGEFDMVVAMYHDQALAPFKLVAFDKGVNFTVGLPFIRTSPDHGTAY 291

Query: 302 ELAGRGKADVGSFITALNLAIKMIV 326
           ++A +GKA+  S + A+ LA++M V
Sbjct: 292 DIAWQGKAEPTSLLEAIKLAVRMEV 316


>UniRef50_B9XEU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=bacterium
           Ellin514 RepID=B9XEU4_9BACT
          Length = 330

 Score =  177 bits (448), Expect = 7e-43,   Method: Compositional matrix adjust.
 Identities = 130/327 (39%), Positives = 173/327 (52%), Gaps = 19/327 (5%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           I  G+  GIGP++ ++    E   +    ++  DA LL      L L L   PYS     
Sbjct: 7   ICLGDVTGIGPEVTLKALAAEAGADDTRYLLIGDAGLLQKLNQGLNLNLDFHPYS----- 61

Query: 66  QPQTAGTL---TLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
            P+  G +    L+P AL   +  G     N    V  L  A   CLN E   +IT PV+
Sbjct: 62  GPRNGGRIFVHDLMPGALPENLKPGAPEAAN--AAVAWLKDATQRCLNHELDGMITAPVN 119

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE-----LRVALATTHLPLRDIADAIT 177
           K  I  AG  F G TEF    + A +  MML   +     LRV LATTH+PL+ +++ +T
Sbjct: 120 KESIIRAGHAFVGQTEFISNMAGADRSAMMLLGHDDRDRWLRVVLATTHVPLKAVSEKLT 179

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
            A +   I           G+   R+ VCGLNPHAGEGG +GTEEI  + P +   + + 
Sbjct: 180 QAKVELAIERAAQSC-VDLGLPRARVAVCGLNPHAGEGGELGTEEITVVTPAVEACKRKN 238

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           + ++GP PAD LF   +  + D V+AMYHDQGL  LK  GF  G+N TLGLPFIRTS DH
Sbjct: 239 LDVHGPFPADALFHYVFKGDYDVVVAMYHDQGLVPLKMIGFENGINWTLGLPFIRTSPDH 298

Query: 298 GTALELAGRGKADVGSFITALNLAIKM 324
           GTA  +AGRG A+  S I A+ LA ++
Sbjct: 299 GTAYNIAGRGIANPSSMIAAIRLAKQL 325


>UniRef50_C5SNX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Asticcacaulis
           excentricus CB 48 RepID=C5SNX7_9CAUL
          Length = 319

 Score =  176 bits (447), Expect = 8e-43,   Method: Compositional matrix adjust.
 Identities = 103/267 (38%), Positives = 147/267 (55%), Gaps = 12/267 (4%)

Query: 73  LTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIP 132
           L +L   L AP   G     +  ++   +    + CL+G    LIT P+ K V+  +G  
Sbjct: 48  LPVLDRPLSAPPLPGNPDPVHAPHITSWIREGVELCLSGAARGLITAPIAKSVLYASGFA 107

Query: 133 FTGHTEFFEERSQA------KKVVMMLATEE------LRVALATTHLPLRDIADAITPAL 180
           F GHTE+  + + A      +  VMML   +      LRV LAT H PL ++   ++   
Sbjct: 108 FPGHTEYLGDLTAAAPYPGTRGPVMMLTAPDAVNESALRVVLATIHTPLSEVKAHLSAET 167

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +  +  + H  L   FG+A+PR+++ GLNPHAGE G +G EE+D + P++  L  +G+ +
Sbjct: 168 VRTLAHVTHEALIRDFGVAKPRLVLAGLNPHAGEDGTIGREEVDLLQPLVAALCNEGLDI 227

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
           +GPLPADTLF  +     DA L +YHDQGL  LK   F  GVNITLGLP +RTS DHGT 
Sbjct: 228 SGPLPADTLFHAEARRTYDAALCLYHDQGLIPLKTLDFWGGVNITLGLPLVRTSPDHGTG 287

Query: 301 LELAGRGKADVGSFITALNLAIKMIVN 327
             + G+G A   S I A+  A  + +N
Sbjct: 288 FAIVGKGIARPDSLINAIRAAHDISLN 314


>UniRef50_B8IXF1 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Methylobacterium nodulans ORS 2060
           RepID=B8IXF1_METNO
          Length = 336

 Score =  176 bits (446), Expect = 9e-43,   Method: Compositional matrix adjust.
 Identities = 109/304 (35%), Positives = 170/304 (55%), Gaps = 9/304 (2%)

Query: 9   ITPGEPAGIGPDLVVQ-LAQRE--WPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           +T G+ AGIGP++VV+ L + E       +V  DA ++ +  A+ GLP  +R  S  + A
Sbjct: 11  VTMGDAAGIGPEIVVRALVEPEVREACHAIVIGDAGIMRDAVALTGLPCEIRAVSSVAEA 70

Query: 66  QPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
           + +  GT+ +L +    R+    G+++   G   VE + RA    L+GE  A+ + P +K
Sbjct: 71  EFRD-GTIDVLDLRNIARSDFEPGRISAACGRAFVEYIRRAARMALSGEIDAVASAPTNK 129

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             ++ AG  + G TE F E S++     +L   ++RV L ++H+ L      +T   +  
Sbjct: 130 EAMHAAGEIYPGQTEIFAEESRSTDPFTILTGGKMRVFLVSSHVSLSQAIALVTQPRIEL 189

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
           VI      L+  +GI +P I V GLNPHAG+GG  G EEI+ +IPVL  LRA+G+++ GP
Sbjct: 190 VIRKAVASLKELWGIDDPLIGVAGLNPHAGDGGLFGREEIEHVIPVLERLRAEGIRIEGP 249

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
            PAD+++        D V+ MYHDQG+  LK  G+   V +  G P IRT+  HGTA ++
Sbjct: 250 GPADSVYDRADRGAYDGVIGMYHDQGVIPLKRYGY---VTVISGTPIIRTTAGHGTAYDI 306

Query: 304 AGRG 307
           A +G
Sbjct: 307 AWKG 310


>UniRef50_C7M3J3 4-hydroxythreonine-4-phosphate dehydrogenase n=6 Tax=Flavobacteria
           RepID=C7M3J3_CAPOD
          Length = 352

 Score =  176 bits (446), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 108/329 (32%), Positives = 170/329 (51%), Gaps = 9/329 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPN 62
           +V I+ G+  G+G +++++  +    +EL   ++ A   L++ +        T   +   
Sbjct: 7   KVGISIGDMNGVGLEIILKTFEDHQILELCTPIIFASNKLVSFQKKHFN---TTANFQGI 63

Query: 63  SPAQPQTAGTLTLLPVALRAP-VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
              +    G L +L      P VT GQ   E G Y   +L  A +   N     L+T P+
Sbjct: 64  ESVEAAIDGKLNVLNCWKETPTVTFGQETEEGGKYAFLSLQAAVEALKNNSIDVLVTAPI 123

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           +K  I      F GHT++  +      + M + +E+L+V L T H+PL++++  IT AL+
Sbjct: 124 NKNNIQSDAFHFPGHTDYLAQELNGTSL-MFMVSEDLKVGLLTDHVPLKEVSSLITEALI 182

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR-AQGMKL 240
            E   +++  L   F +  P+I V G+NPH G+ G +G E+ + + P L +L   + + +
Sbjct: 183 MEKARLMNESLIKDFRLQRPKIAVLGINPHCGDKGVIGNEDDEVLRPALKKLYFDENILV 242

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP  AD+ F  +   N DAVLA YHDQGL   K   FG GVN T GL  +RTS DHGTA
Sbjct: 243 FGPFAADSFFGSQTYRNYDAVLAPYHDQGLIAFKTIAFGSGVNYTAGLSKVRTSPDHGTA 302

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNTQ 329
            E+AG+G AD  SF  A+  A+ +  N +
Sbjct: 303 YEIAGKGIADPESFRHAIFTALDVFRNRE 331


>UniRef50_C6E7W5 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Geobacter
           RepID=C6E7W5_GEOSM
          Length = 348

 Score =  176 bits (445), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 125/318 (39%), Positives = 158/318 (49%), Gaps = 18/318 (5%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + +T G+P GIGP+++           L   +V  D   +    A+ G+ L +       
Sbjct: 20  IAVTMGDPCGIGPEIIAAALADPAITSLCRPLVIGDREAMERGIAVAGVKLAVASAPDLL 79

Query: 64  PAQPQTAGTLTLLPVA--------LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
           P      GTL L  ++          AP TAG      G      +  A   CL+G   A
Sbjct: 80  PPAIVAPGTLYLRELSRLKLDEIPYGAPTTAG------GDACYRYICEAARLCLDGTAQA 133

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           + T P++K  +N AG  + GHTE   E +   +VVMMLA E LRV L T H PL  + + 
Sbjct: 134 MATAPINKESMNSAGHDYPGHTELLAELTGTPEVVMMLAGERLRVTLVTIHEPLARVPEL 193

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           +T   +   I I H  L   F  A PR+ V  LNPH GEGG  G EE   I P +   R 
Sbjct: 194 VTFDRVLSTIRITHDALSRWFCRA-PRLAVLALNPHCGEGGMFGDEESRIIAPAVAAARE 252

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
            G+   GP+ ADTLF        DAV+ MYHDQGL  LK   F  GVN+TLGLP IRTSV
Sbjct: 253 AGIDAAGPVSADTLFHFAAKGGYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSV 312

Query: 296 DHGTALELAGRGKADVGS 313
           DHGTA +LAG GKA   S
Sbjct: 313 DHGTAYDLAGTGKASAES 330


>UniRef50_B4U950 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Aquificaceae
           RepID=PDXA_HYDS0
          Length = 310

 Score =  175 bits (444), Expect = 2e-42,   Method: Compositional matrix adjust.
 Identities = 112/315 (35%), Positives = 171/315 (54%), Gaps = 19/315 (6%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVE--LVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           IT G+PAGIGP+L+++L Q++   E   V+  +  +L + +++LG        +     +
Sbjct: 6   ITMGDPAGIGPELILKL-QKDMEDENAYVIYGEEYILKHASSVLGQNFYYEKVNSVDDVK 64

Query: 67  PQTAGTLTL-LPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
            +    ++L L  AL    ++G+LA+         LARA    ++ +   ++T P++K  
Sbjct: 65  DKGIYLISLSLKGALEPSPSSGKLAIA-------YLARATADAISKKLNGILTMPINKYF 117

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
              +G  F G TE+       K   MM+ ++ ++V LAT H+PL+DIA+AI   L+ + I
Sbjct: 118 AKASGFSFNGQTEYLAFADNKKDFAMMMYSDAIKVVLATIHIPLKDIANAINVELIKQKI 177

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
            ++  D   K+    P I V GLNPHAGEGG +G EE   IIP + +       + GP+P
Sbjct: 178 KLIK-DYIPKYFRFIPTIKVLGLNPHAGEGGLIGDEEAKIIIPAIRD-----EDVVGPIP 231

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
            DT F    +   D  L MYHDQGL   K   F +G N+T+GL F+RTS DHGTA ++A 
Sbjct: 232 PDTAFID--IKKDDIFLCMYHDQGLIPFKMLAFDKGSNVTIGLSFLRTSPDHGTAYDIAY 289

Query: 306 RGKADVGSFITALNL 320
           +G A V S   +L L
Sbjct: 290 KGLARVDSAGYSLEL 304


>UniRef50_C7PP38 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Bacteria
           RepID=C7PP38_CHIPD
          Length = 354

 Score =  175 bits (444), Expect = 2e-42,   Method: Compositional matrix adjust.
 Identities = 104/314 (33%), Positives = 152/314 (48%), Gaps = 6/314 (1%)

Query: 9   ITPGEPAGIGPDLVVQLAQR----EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           IT G+   IG +L+++        E+   ++  ++ T+   R  M       +     + 
Sbjct: 14  ITVGDINSIGTELIIKTFADARMLEFCTPVIFASNKTINFYRKLMNENNFNYQSVKEFAR 73

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
              +           ++  +T G L    G Y   +LA A +    G    LIT P+HK 
Sbjct: 74  LNHKQVNVFNCWEEEVQ--ITPGVLNEVGGKYAARSLAVAIECLKEGHIQGLITAPIHKK 131

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
            I      +TGHT +  +   AK V+M +  + +RV L T H+P+ +I+  +    +   
Sbjct: 132 NIQGEQFNYTGHTPYLRDAFDAKDVLMFMTADNMRVGLLTEHVPVAEISKYVKKDNILAK 191

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL 244
           + ++   L   FGI  PRI V GLNPHAG+ G +G EEI  IIP +   +  G+   GP 
Sbjct: 192 LQMMEDSLIKDFGIDSPRIAVLGLNPHAGDDGLIGQEEITEIIPAIKHAKNNGLLCFGPY 251

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELA 304
            AD  F     +  D VLAMYHDQGL   K    G G+N T GLP +RTS DHGTA ++A
Sbjct: 252 SADAFFARNMHEQFDGVLAMYHDQGLIPFKSLATGNGINYTAGLPIVRTSPDHGTAFDIA 311

Query: 305 GRGKADVGSFITAL 318
           G+  AD  SF  A+
Sbjct: 312 GKNLADHNSFRQAI 325


>UniRef50_C6C747 4-hydroxythreonine-4-phosphate dehydrogenase n=17 Tax=Bacteria
           RepID=C6C747_DICDC
          Length = 341

 Score =  173 bits (439), Expect = 6e-42,   Method: Compositional matrix adjust.
 Identities = 110/330 (33%), Positives = 171/330 (51%), Gaps = 23/330 (6%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELV---VCADATLLTNRAAMLGLPLTLRPYSPNS 63
           V +T G+PAGIGP++ V     +   E     +     ++    A+      +     +S
Sbjct: 15  VALTIGDPAGIGPEISVATMMNQAVYEECRPFLIGSVPIIQRAMAIWNCDFAINVI--HS 72

Query: 64  PAQPQ-TAGTLTLLP---------VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEF 113
           PA+ + T GTL +L          V  +    AGQ++++   YV++++A      + GE 
Sbjct: 73  PAEARFTWGTLDVLETGDYDCDSIVWGKVQKLAGQMSLD---YVMKSIALG----MAGEI 125

Query: 114 AALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIA 173
             + T P+HK  I  AG    GHTE ++  + +   + M   ++LRV   + H+ L+D  
Sbjct: 126 DVVSTAPIHKEAIKLAGCKLPGHTEIYQVETGSDYGLTMFHVQKLRVFFVSRHMALKDAC 185

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL 233
           D      +   +  +HH+  T   I +PRI V  LNPHA + G  G EE D +IP +   
Sbjct: 186 DYANKERVLACVQQIHHEF-TALNIPQPRIAVAALNPHASDNGLFGHEEKDNLIPAVQAA 244

Query: 234 RAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
           +A G+   GP+PAD++F    L + DA+L++YHDQG    K   F R V IT GLPF+R+
Sbjct: 245 QALGINAIGPVPADSVFHQGKLGHYDAILSLYHDQGHIACKTLDFERSVTITFGLPFMRS 304

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIK 323
           SVDHGTA ++AG GKA   S + +  +A +
Sbjct: 305 SVDHGTAFDIAGTGKAGTVSMLESTLVAAR 334


>UniRef50_C0CYU8 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CYU8_9CLOT
          Length = 331

 Score =  173 bits (438), Expect = 8e-42,   Method: Compositional matrix adjust.
 Identities = 106/323 (32%), Positives = 170/323 (52%), Gaps = 9/323 (2%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           ++I  G+PAGIGP++  +   RE  ++    VV  D  ++     ++ LPLT+  ++ N 
Sbjct: 5   ILIPMGDPAGIGPEIAAKALAREETLQRARCVVVGDRQVMEQAVRIVDLPLTI--HTINE 62

Query: 64  PAQ---PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
           P +    +    L  L          G+++   G    E +A +      G+ AA+ T P
Sbjct: 63  PEEGRFEERVINLIDLANVDMGQFKRGEISAMCGRAAYEYIATSISLANAGKAAAVSTTP 122

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           ++K  +  AG+P+ GHTE F   +     + M     +RV   T H+ LR   D IT   
Sbjct: 123 INKESLRAAGVPYIGHTEIFGALTGTPDPLTMFEVRNMRVFFLTRHVSLRKACDMITKER 182

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           + + +      L+ + G+ +  + + GLNPH+GE G  G EE++ I P + EL+AQG K+
Sbjct: 183 VIDYVKRCTQALK-QLGVEDGTMAIAGLNPHSGEHGLFGDEEMEAIYPAVEELQAQGYKV 241

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+ AD++F        ++VL++YHDQG    K   F R + +T G+P +RTSVDHGTA
Sbjct: 242 AGPVGADSVFHMALQGKFNSVLSLYHDQGHIATKTLDFERTIAVTAGMPILRTSVDHGTA 301

Query: 301 LELAGRGKADVGSFITALNLAIK 323
           +++AG G A   S + A+ LA K
Sbjct: 302 MDIAGTGIASDVSMVEAIRLAAK 324


>UniRef50_A1TTF8 4-hydroxythreonine-4-phosphate dehydrogenase n=10
           Tax=Burkholderiales RepID=A1TTF8_ACIAC
          Length = 374

 Score =  172 bits (436), Expect = 2e-41,   Method: Compositional matrix adjust.
 Identities = 128/340 (37%), Positives = 173/340 (50%), Gaps = 25/340 (7%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVC---------ADATLLTNRAAMLGLPLTLR 57
           + +T G+PAGIGP+++ + A R+ P  +  C           A     R     LPL L 
Sbjct: 28  LAVTQGDPAGIGPEIIAK-AFRDAPDAMRGCFVVGGVETLRRAARCIARPGEPSLPLALL 86

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                + A P       L    L   +  G +  E G    + +  A    L GE A L+
Sbjct: 87  QAPEEARAVPPRC-VPLLPLPGLPGSIPFGAVHAEGGRAAADCVTWAARAALRGEIAGLV 145

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKK--------VVMMLATEELRVALATTHLPL 169
           T P+HK  ++ AG+   GHTE  +  +            V MMLA++ELR  L + H+ L
Sbjct: 146 TAPLHKEALSAAGVHHPGHTELLQAEAARHAGVPVADMPVRMMLASDELRTVLVSIHVSL 205

Query: 170 RDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPV 229
           R+   A+T   +   + I H  LR   G   PRI V GLNPHAGEGG  G EEI+ I P 
Sbjct: 206 REAIAAVTQDNVLRTLEITHAALRRGLGRG-PRIGVAGLNPHAGEGGLFGREEIEAIAPA 264

Query: 230 LNELRAQGMKLNGPLPADTLFQ-----PKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNI 284
           +   RA G+  +GP   DT+F      P+     D VLAMYHDQGL  +KY G  +GVN+
Sbjct: 265 IAAARALGIDAHGPFAPDTVFMRARSTPQRPGEFDVVLAMYHDQGLIPVKYLGVDKGVNV 324

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           TLGLP +RTS DHGTA ++AGRG AD  S + A+  A ++
Sbjct: 325 TLGLPLVRTSPDHGTAFDIAGRGVADASSLVEAVLAARRL 364


>UniRef50_B4D0B0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Chthoniobacter
           flavus Ellin428 RepID=B4D0B0_9BACT
          Length = 296

 Score =  172 bits (435), Expect = 2e-41,   Method: Compositional matrix adjust.
 Identities = 99/231 (42%), Positives = 132/231 (57%), Gaps = 8/231 (3%)

Query: 99  ETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEEL 158
           E L  +    L GE AA++TGP+HK  +   G  F G TEF+  R++ +   M L    L
Sbjct: 62  EALEESARLALAGEIAAVVTGPIHKARMQAIGFEFPGQTEFYAARAKEENFAMCLTGGAL 121

Query: 159 RVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAE--PRILVCGLNPHAGEGG 216
            VAL T H+PLR +A++++ +   E+I + H          +  PR+ V GLNPHAGE G
Sbjct: 122 TVALVTAHIPLRTVAESLSSS---EIIRVGHLLADFLLLRLDRKPRLAVAGLNPHAGESG 178

Query: 217 HMGTEEIDTIIPVLNELRAQ---GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVL 273
            +G EEI+ I P +  LR +     +  GP+  DT+F        D VL MYHDQGL  L
Sbjct: 179 ALGREEIELIEPAVALLRGELGDTAECIGPISPDTVFHRAAGGEFDGVLCMYHDQGLIPL 238

Query: 274 KYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           K   F  GVN+TLGLPF RTS DHGTA E+AG+  A   S I A+NLA ++
Sbjct: 239 KLHAFDSGVNVTLGLPFPRTSPDHGTAFEIAGKDIARPDSMIAAINLAAEL 289


>UniRef50_B3DY74 Pyridoxal phosphate biosynthesis protein n=1 Tax=Methylacidiphilum
           infernorum V4 RepID=B3DY74_METI4
          Length = 294

 Score =  171 bits (434), Expect = 2e-41,   Method: Compositional matrix adjust.
 Identities = 90/216 (41%), Positives = 131/216 (60%), Gaps = 2/216 (0%)

Query: 112 EFAALITGPVHKGVINDAGIPFTGHTEFFEERSQA--KKVVMMLATEELRVALATTHLPL 169
           E  A++T P+HK  +   G P+ G TEFF  ++     KV+M +++ ++ ++L +TH+ L
Sbjct: 73  EIQAIVTSPIHKDNLFQIGFPYPGQTEFFAAKAGVPRDKVIMAMSSPKINLSLLSTHVSL 132

Query: 170 RDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPV 229
                +IT   +     +L   L+     +   I + GLNPH GEGG+ G EE +T IP 
Sbjct: 133 YQAIKSITKDKIKLASVLLLEFLKKIKKKSNLTIAISGLNPHCGEGGNFGNEENETFIPA 192

Query: 230 LNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLP 289
           +NELR Q + ++GP+  D++F+   L   D V+A YHDQGL   K   F  GVN+TLGLP
Sbjct: 193 INELRNQELPVHGPVSPDSVFREVLLGKYDGVVASYHDQGLIPFKLVSFYSGVNVTLGLP 252

Query: 290 FIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
            IRTS DHG AL++AG+ KAD  S I+A+ LA K+I
Sbjct: 253 LIRTSPDHGVALDIAGQNKADPRSLISAIKLACKLI 288


>UniRef50_A7HIW4 4-hydroxythreonine-4-phosphate dehydrogenase n=4
           Tax=Anaeromyxobacter RepID=A7HIW4_ANADF
          Length = 372

 Score =  171 bits (432), Expect = 4e-41,   Method: Compositional matrix adjust.
 Identities = 123/324 (37%), Positives = 169/324 (52%), Gaps = 12/324 (3%)

Query: 6   RVVITPGEPAGIGPDLVVQ-LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           R+ ++ G+P+G+G ++  + LA     +   V  DA +L    A  GLP  L      +P
Sbjct: 43  RIAVSLGDPSGVGAEVTAKALAALAGQLVPYVFGDARVLARELAGSGLPCVL----AGAP 98

Query: 65  AQPQTA-GTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
             P+ A   +T LP      V  G+     G   +  L  A +    G+  AL T PV K
Sbjct: 99  LPPEGALVAVTRLPAGA---VRPGRPDPRAGAAQLAALEAAFEAIRRGDADALTTAPVSK 155

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             +  A   F GHTE+ E R    + VMMLA E+L+VAL T H+    +  A+TP  + E
Sbjct: 156 AQVARALPGFVGHTEWLEARCGVGRSVMMLAGEKLKVALVTNHVAFWKLRRALTPERIAE 215

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            +A+ H  LR   G+A PR+ +  LNPHAGE G  G EE   +   L+     G +  GP
Sbjct: 216 TLALTHRALREDLGLARPRLALAALNPHAGEEGAFGAEETTLLAGALSRAARAGARAQGP 275

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGL-PV--LKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            PAD++F    L   DAV+A+YHDQGL PV  L        VN+TLGLP +RTS DHG A
Sbjct: 276 FPADSVFFRAALGEFDAVVALYHDQGLIPVKLLDAVCADPAVNVTLGLPIVRTSPDHGVA 335

Query: 301 LELAGRGKADVGSFITALNLAIKM 324
            ++AG G A+  S I AL LA ++
Sbjct: 336 YDIAGHGVANPASMIAALKLAARI 359


>UniRef50_A8ME07 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Archaea
           RepID=A8ME07_CALMQ
          Length = 325

 Score =  171 bits (432), Expect = 4e-41,   Method: Compositional matrix adjust.
 Identities = 113/321 (35%), Positives = 167/321 (52%), Gaps = 18/321 (5%)

Query: 6   RVVITPGEPAGIGPDLVVQ--LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           R+ +T G+PAGIG ++V +  L      VEL +  +   L +   +LG+ L +     N 
Sbjct: 3   RIGVTLGDPAGIGYEIVAKALLKLSNPEVELTLIGN---LEHFKRVLGM-LKISDDVLNG 58

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
                  G           P   G++  E G   +E++ R  +  + GE  AL T P++K
Sbjct: 59  VRFIDIPG----------GPFEFGKVQEEAGRVSLESVRRGVELAMAGEIDALATAPINK 108

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
                AG  +  HT   +  +++K+ + +  T  LR+   T H+PL D    I  A +  
Sbjct: 109 EAWIKAGSSYIDHTTLLQALTKSKESLTVFETRRLRILFLTRHMPLADAIKEIKAANVLN 168

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ-GMKLNG 242
            I      L+   G+   RI V  LNPHAGEGG +G EEID I P + E R + G+   G
Sbjct: 169 GIINASRVLKA-LGVRRGRIAVAALNPHAGEGGLLGREEIDEITPAVKEARVKYGIDAYG 227

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
           P+PAD++F      + D VL++YHDQG    K   F R V++TLGLPF+RTSVDHGTA +
Sbjct: 228 PIPADSVFHLAAQGHYDIVLSLYHDQGHIAAKTYDFKRTVSLTLGLPFLRTSVDHGTAFD 287

Query: 303 LAGRGKADVGSFITALNLAIK 323
           +AG+G AD  S + A+  A++
Sbjct: 288 IAGKGIADETSMLEAIRKAVR 308


>UniRef50_A6L8G2 4-hydroxythreonine-4-phosphate dehydrogenase n=7 Tax=Bacteroidales
           RepID=A6L8G2_PARD8
          Length = 369

 Score =  171 bits (432), Expect = 4e-41,   Method: Compositional matrix adjust.
 Identities = 115/328 (35%), Positives = 164/328 (50%), Gaps = 8/328 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNR-AAMLGLPLTLRPYSPNSP 64
           +V IT G+  GIG +++++        EL  C      +++ AA     L L P + N  
Sbjct: 7   KVGITHGDINGIGYEVILKTFSDTRMAEL--CTPIIYGSSKIAAYHRKALELPPINMNII 64

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVEN---GHYVVETLARACDGCLNGEFAALITGPV 121
           +  + AG   +  +      T  +L+      G    + L  A      G    L+T P+
Sbjct: 65  SHAEDAGVNRVNIINCVEDETKVELSKSTPVAGESAFKALEAAVTDMKRGVVDVLLTAPI 124

Query: 122 HKGVINDAGIPFTGHTEFFEE--RSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           +K  I +    F GHTE+ E+      KK +M+L  ++LRVAL T H+PL  +A ++   
Sbjct: 125 NKHNIQNEDFHFPGHTEYLEKCFGGLDKKALMILMKDDLRVALVTGHIPLSQVASSLNVG 184

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +   + I +  L+  FGI +PRI V  LNPHAG+ G +GTEE   IIP + E   +G+ 
Sbjct: 185 DIVNKLRIFNQSLKQDFGIVKPRIAVLSLNPHAGDAGLLGTEEETIIIPAMQEAEKKGVM 244

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
             GP  AD  F  +  D  D VLAMYHDQGL   K      GVN T GLP +RTS  HGT
Sbjct: 245 SFGPYAADGFFGSQMYDKFDGVLAMYHDQGLAPFKTLAMDDGVNYTAGLPIVRTSPAHGT 304

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVN 327
           A ++AG+  A   SF  AL  A+ +  N
Sbjct: 305 AYDIAGQNVASEESFRQALYAALDIFRN 332


>UniRef50_Q1DF36 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Cystobacterineae RepID=Q1DF36_MYXXD
          Length = 346

 Score =  170 bits (431), Expect = 5e-41,   Method: Compositional matrix adjust.
 Identities = 107/240 (44%), Positives = 138/240 (57%), Gaps = 4/240 (1%)

Query: 87  GQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQA 146
           G+ + E G      +  A D    G   AL T PV K  I+ AGIPF GHTE   E +  
Sbjct: 84  GEPSREGGRAQYAFVTAAIDAMRAGHVDALCTAPVSKEQISRAGIPFMGHTEVLAE-AFG 142

Query: 147 KKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVC 206
             V+M++    +RVALAT H+PL D+   +T   L   + +L   L    G  +PRI V 
Sbjct: 143 VDVMMLMDGPRVRVALATNHVPLADLPRLLTVDGLTAQLKLLSRSLEPVVG-HKPRIAVL 201

Query: 207 GLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLF-QPKYLD-NADAVLAM 264
           GLNPHAGEGG +G EE++ I P + + RA  +  NGP+PAD LF +P  +    DAVLAM
Sbjct: 202 GLNPHAGEGGLLGREEVEVIGPAIRKARAARVDANGPIPADGLFAKPDEVGARYDAVLAM 261

Query: 265 YHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           YHDQGL   K   F R VN+TLGLP  RTS DHGTA  +AG+G+A     + AL  A ++
Sbjct: 262 YHDQGLIPAKALDFERTVNVTLGLPVPRTSPDHGTAYAIAGKGEASCVPMVEALLKAAQL 321


>UniRef50_B2KET4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Elusimicrobium
           minutum Pei191 RepID=B2KET4_ELUMP
          Length = 309

 Score =  170 bits (431), Expect = 5e-41,   Method: Compositional matrix adjust.
 Identities = 113/335 (33%), Positives = 170/335 (50%), Gaps = 47/335 (14%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLL------------TNRAAMLG 51
           + IT G+P GIGP++VV+  Q +   +    VV  D   L             + AA+L 
Sbjct: 5   IAITTGDPMGIGPEIVVKALQDKRVTDACTPVVIGDKKALIKNGLQEGAFSVVDTAAILT 64

Query: 52  LPLTLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNG 111
            PL      P +P      G  +   V + + +T+                        G
Sbjct: 65  KPL------PETPGPTVYGGLTSFNAVTMASRITS-----------------------KG 95

Query: 112 EFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRD 171
           E  A++T P+ K   N AG+ +TGHT+F +E S+   V+MM  T +L V L + H  ++D
Sbjct: 96  EVKAMVTAPISKESWNMAGVKYTGHTDFLKEFSRIDHVLMMFTTNKLTVGLVSEHAAIKD 155

Query: 172 IADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLN 231
           ++  IT   +     +L++ L +   + +PRI V  +NPHAG+GG +G EE + I P L+
Sbjct: 156 LSKEITSKKIIHAAQLLNNFLISN-SVKKPRIGVSAVNPHAGDGGKLGMEEKEIIAPALS 214

Query: 232 ELRAQGMKLNGPLPADTLFQPKYLDNA-DAVLAMYHDQGLPVLKYQGFGRGVNITLGLPF 290
            L+ +   + GP+P D L+  KY   A D +L MYHDQ L  LK       V++T GLPF
Sbjct: 215 VLKKENFNILGPMPVDALWT-KYTKGAYDGILCMYHDQALLGLKLCAQEPIVHLTYGLPF 273

Query: 291 IRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
           IRTS  HGTA ++AG+ +AD  S I+A+  A+  I
Sbjct: 274 IRTSPTHGTAFDIAGKNEADPSSMISAILYAVSHI 308


>UniRef50_Q92X16 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=18
           Tax=Alphaproteobacteria RepID=PDXA2_RHIME
          Length = 321

 Score =  170 bits (430), Expect = 7e-41,   Method: Compositional matrix adjust.
 Identities = 110/322 (34%), Positives = 165/322 (51%), Gaps = 22/322 (6%)

Query: 9   ITPGEPAGIGPDLVV----QLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           IT G+P G+GP++ V    +++  +     +    ATL   R A LGL + L+PY  +  
Sbjct: 7   ITMGDPCGVGPEITVRSLAEMSAADREATRIYGNLATLEAAREA-LGLSVDLQPYVVDLT 65

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
            +               AP+  G L+   G      + RA      G    ++T P++K 
Sbjct: 66  VEG--------------APLPWGSLSAVAGDAAFRFIERAVRDAEAGNIGCIVTAPINKE 111

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRD-IADAITPALLHE 183
            +N AG  + GHT      + +    M+LA+E L+V   +TH+ L++ I  A T  +L  
Sbjct: 112 ALNMAGHHYDGHTGMLRSLTGSSAAYMLLASERLKVIHVSTHVSLKEAIGRATTERVLAT 171

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
           + A   H  R   G   PRI V G+NPH GE G  GTE+ D I P +   R +G+ + GP
Sbjct: 172 IRAGNAHLKR--IGYEHPRIAVAGINPHCGENGLFGTEDDDQIGPAVAAAREEGIDVQGP 229

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           + ADT+F   Y    D V+A YHDQG   +K   F   VN+++ LP  RTSVDHGTA ++
Sbjct: 230 ISADTVFHRAYSGGFDLVVAQYHDQGHIPIKLVAFDTAVNVSVDLPIDRTSVDHGTAFDI 289

Query: 304 AGRGKADVGSFITALNLAIKMI 325
           AG+G A+ G+  +A+  A K++
Sbjct: 290 AGKGIANHGNLNSAIAYARKLV 311


>UniRef50_Q8DHB4 4-hydroxythreonine-4-phosphate dehydrogenase n=13 Tax=Cyanobacteria
           RepID=PDXA_THEEB
          Length = 341

 Score =  170 bits (430), Expect = 7e-41,   Method: Compositional matrix adjust.
 Identities = 121/336 (36%), Positives = 170/336 (50%), Gaps = 32/336 (9%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELV----VCADATLLTNRAAMLGLPLTLRPYSPN 62
           + +T G+PAGIGP+++++ A    P EL+    +     +L    A L      +     
Sbjct: 3   LALTLGDPAGIGPEILLK-ALAHLPSELLGQFFIAGTGQVLEETYARL----CQQGQVAI 57

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
            PAQ      L L    L   +  G+ +V +G      L  A    + GE A ++T P+ 
Sbjct: 58  DPAQ------LQLWEHPLDEVIVPGRPSVASGTASFAYLKTAIQRAIAGEVAGIVTAPIS 111

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE------LRVALATTHLPLRDIADAI 176
           K     AG  F G TE     +    V M+           L   LATTH+PL+ +  A+
Sbjct: 112 KACWQAAGYSFPGQTEVLAHLTGTAHVGMLFLGRSPVTHWVLTTLLATTHIPLQAVPRAL 171

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           TP  L+E +A+L   LR +  +  PRI + GLNPH+GE GH+G EE+  +IP L   + Q
Sbjct: 172 TPEGLNEKLALLIQFLRERRHLERPRIAIAGLNPHSGEQGHLGQEEVTWLIPWLAAAQQQ 231

Query: 237 --GMKLNGPLPADTLF---------QPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNIT 285
              ++L GP+P DTL+         +P      DA LA+YHDQGL  +K   F   VN T
Sbjct: 232 YPEVELIGPVPPDTLWIGAADAWWGRPAPATAYDAYLALYHDQGLIPVKMLAFREAVNTT 291

Query: 286 LGLPFIRTSVDHGTALELAGRGKADVGSFITALNLA 321
           +GLPFIRTS DHGTA ++AG G AD  SF+ A+  A
Sbjct: 292 IGLPFIRTSPDHGTAFDIAGTGVADPQSFLAAIAWA 327


>UniRef50_D0J9Z1 4-hydroxythreonin-phosphate dehydrogenase n=1 Tax=Blattabacterium
           sp. (Periplaneta americana) str. BPLAN
           RepID=D0J9Z1_BLASP
          Length = 363

 Score =  167 bits (422), Expect = 5e-40,   Method: Compositional matrix adjust.
 Identities = 105/332 (31%), Positives = 174/332 (52%), Gaps = 8/332 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLT-LRP 58
           K  +V ++ G+  GIG ++ +++ +++  ++    ++     L +    +L + +  +R 
Sbjct: 27  KKIKVGVSTGDINGIGIEIFLKVCRKKKLLDFFTPILFGSIKLCSYYKKILNIEVNNMRE 86

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                         L +    ++  +   ++  ++G Y + +L +A      G+   L+T
Sbjct: 87  IKNLKDIVDYKINVLNIWKEDIKFDLI--KINQDSGKYPILSLKKATKALKEGKIDVLVT 144

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            PV+K  +N     F GHTE+ +   + + +++M+  + L++AL T HLPL+++   IT 
Sbjct: 145 APVNKNWMNHKEFSFFGHTEYLQNILEGESLMLMIH-DTLKIALVTNHLPLKNVTHEITT 203

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL-RAQG 237
             + + I ILH  L   F I +P+I V G NPH+GE G +G EE   I P ++ L + QG
Sbjct: 204 KKIIKSIKILHKSLIMDFSIEKPKIAVLGCNPHSGENGLIGDEEKTKIKPAIDSLFQKQG 263

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
             + GP   D  F  ++  N DAVLAMYHDQGL   K   F  GVN T GL  IRTS DH
Sbjct: 264 FLVFGPYSPDGFFGNQHYRNFDAVLAMYHDQGLIPFKTLTFNEGVNFTAGLSHIRTSPDH 323

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           G A ++A +G A+  SF  A+  AIK+  N +
Sbjct: 324 GVAYDIAKKGIANENSFEEAIFSAIKIFKNRK 355


>UniRef50_Q2CJB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Oceanicola
           granulosus HTCC2516 RepID=Q2CJB0_9RHOB
          Length = 338

 Score =  166 bits (421), Expect = 7e-40,   Method: Compositional matrix adjust.
 Identities = 117/330 (35%), Positives = 169/330 (51%), Gaps = 18/330 (5%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + +TPG+  GIGP+LV ++       E   +V+  DA ++   A   G+ LTL P    S
Sbjct: 8   IALTPGDCTGIGPELVARIVHDGRLAEVARIVLVGDARVIERGARFAGVELTLAPV--ES 65

Query: 64  PAQPQTAGTL-------TLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
           PA+    G          + P AL  P+  G+    +G    +TLARA +    G+  A+
Sbjct: 66  PAKATFDGDAVPIVDLGNIDPDAL--PL--GEPDPTSGRLTGDTLARAIEFARAGKVDAI 121

Query: 117 ITGPVHKGVINDAGIPF-TGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
              P++K  +   G  F   H  F    +       M   E   +   T+H+ LR+  D 
Sbjct: 122 SFAPLNKRAMFLGGWEFPDEHKMFAHLLAHEGPFSEMNVLEGQWMTRVTSHVSLREAVDQ 181

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           IT   +   + + H  +R K GI  PRI V  LNPH GEGG  G EEI+ I P + E+ A
Sbjct: 182 ITGPNICRALQLAHDTMR-KAGIETPRIAVAALNPHNGEGGLFGREEIEIIRPAVEEMAA 240

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G+   GP P+DT++   +    D+VLAMYHDQG    K +GF +GV +T GL  I T+ 
Sbjct: 241 KGIDCTGPFPSDTVYLKAFAGEFDSVLAMYHDQGQIATKLRGFNKGVTVTAGLETIFTTP 300

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMI 325
            HGTA ++ G+GKAD G+  TAL LA  ++
Sbjct: 301 AHGTAYDIVGQGKADTGASETALRLAATLV 330


>UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Octadecabacter
           antarcticus 238 RepID=B5KE47_9RHOB
          Length = 343

 Score =  166 bits (421), Expect = 9e-40,   Method: Compositional matrix adjust.
 Identities = 103/328 (31%), Positives = 172/328 (52%), Gaps = 12/328 (3%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           ++ I PG+P+GIGP+L+ QL   +   E   +++  D  +    A   G+ L L P +  
Sbjct: 10  KIAIIPGDPSGIGPELIAQLLASDGVSEAADILLVGDTHIWEQGARQAGVRLQLDPIAWA 69

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
           + A+      L +  + + A V   ++ +++G   + TL +A D  + G    ++ GP +
Sbjct: 70  NLAEFSGLRQLEMETIDV-ADVKVAEVTIQSGKSALRTLDQALDLAVAGIVDGVLFGPFN 128

Query: 123 KGVINDAGIPFTGHTEFFEE----RSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           K  +  AG+       +       +    +V ++   ++L     T+H+ LR++AD IT 
Sbjct: 129 KAALTAAGLNAEDEHRYMARYLGFKGYHSEVNVL---DDLMTTRVTSHIGLREVADNITA 185

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + + I ++ HD   K G + P + V  LNPHAG+ G  G EEID + PV+ E + + M
Sbjct: 186 DGVRKAI-MMAHDTLAKAGKSRPHVAVAALNPHAGDNGKFGREEIDILAPVVAEYQGRHM 244

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            ++GP P+DT+F        DAV+ MYHDQG   +K  GF RGV +  GLP    +  HG
Sbjct: 245 HVSGPWPSDTVFLKAKAGEVDAVVTMYHDQGQIAIKLMGFDRGVTVAGGLPIPVVTPAHG 304

Query: 299 TALELAGRGKADVGSFITALNLAIKMIV 326
           TA ++AG+  A+VG+   A NL +++ V
Sbjct: 305 TAFDIAGQSVANVGATRNAFNLLLRLAV 332


>UniRef50_A9GKN1 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Sorangium
           cellulosum 'So ce 56' RepID=A9GKN1_SORC5
          Length = 326

 Score =  164 bits (415), Expect = 4e-39,   Method: Compositional matrix adjust.
 Identities = 102/241 (42%), Positives = 132/241 (54%), Gaps = 11/241 (4%)

Query: 80  LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIP----FTG 135
           L  P   G+   E+G   +  +  A D    G  AAL+TGP  K  I  +G P    F G
Sbjct: 67  LSRPSAFGRPEAEDGAAQLAWIDAATDLVREGVAAALVTGPASKHAIATSGAPGSADFLG 126

Query: 136 HTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTK 195
           HTE    R +A++V M  A+ +L  AL TTH+PLR++ DA++P  +    A+    L   
Sbjct: 127 HTEHLGRRLRAREVTMAFASGKLVTALVTTHVPLREVPDAVSPREVARA-AVWLARLLGD 185

Query: 196 FGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLN----ELRAQG--MKLNGPLPADTL 249
            G   PR+ V  LNPHAGEGG +G EE   I P +      L   G   +L GP+ A+T 
Sbjct: 186 LGRERPRVAVAALNPHAGEGGLLGDEEQVRITPGIRLAARRLSRSGPAAELTGPVGAETA 245

Query: 250 FQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKA 309
           F+       D V+AMYHDQ     K  GFG  VN+TLGLP +RTSVDHGTA +LAG G+A
Sbjct: 246 FRLAARGALDGVVAMYHDQATIPSKLLGFGEAVNVTLGLPIVRTSVDHGTAYDLAGTGRA 305

Query: 310 D 310
           D
Sbjct: 306 D 306


>UniRef50_Q7MAP7 PDXA HOMOLOG n=1 Tax=Wolinella succinogenes RepID=Q7MAP7_WOLSU
          Length = 307

 Score =  164 bits (414), Expect = 5e-39,   Method: Compositional matrix adjust.
 Identities = 107/326 (32%), Positives = 167/326 (51%), Gaps = 32/326 (9%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQ--REWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           ++ ++ G+P GIG ++ ++     ++W  E++   D  +L   +  LG+ +         
Sbjct: 2   KIFVSIGDPNGIGLEIALRSHSGVKDWG-EIIYGVDERVLFEASQRLGIEV--------- 51

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
              PQ    +   P+ L +P+  G ++ E G Y  E+  +  +    GE  A++T PVHK
Sbjct: 52  ---PQD---MECDPLGLESPIAPGVISKEAGRYSFESFKKGVERAKKGEVQAIVTLPVHK 105

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
              + AGIP+ GHTE   E    ++ +MM+  E   +AL T HLPL ++   +    +  
Sbjct: 106 KAWSLAGIPYAGHTEALRE-MMGEEAIMMMGKEGFFIALYTDHLPLSEVPQRVHERGVEG 164

Query: 184 VIAILHHDLRTKFGIAEPRILVCG---LNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
            +  L H L        P +  CG   LNPHAG+ G +G EE      +    +A G +L
Sbjct: 165 FLRRLSHAL--------PAMKACGVLGLNPHAGDQGVLGKEEEGIKRAIERANQALGREL 216

Query: 241 N-GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
             GPL  D  F P +    D  +AMYHDQGL  LK   F   +N++LGLPF+RTSVDHGT
Sbjct: 217 FFGPLVPDVAFIPSWRAKFDHYVAMYHDQGLIALKILYFEESINLSLGLPFVRTSVDHGT 276

Query: 300 ALELAGR-GKADVGSFITALNLAIKM 324
           A ++A R G   + S+  A+ +A+K+
Sbjct: 277 AFDIAYRGGNPSLLSYQNAIKMALKL 302


>UniRef50_D2TK32 Putative uncharacterized protein n=1 Tax=Citrobacter rodentium
           ICC168 RepID=D2TK32_CITRO
          Length = 348

 Score =  161 bits (408), Expect = 2e-38,   Method: Compositional matrix adjust.
 Identities = 110/327 (33%), Positives = 169/327 (51%), Gaps = 14/327 (4%)

Query: 12  GEPAGIGPDLVVQ-LAQREWPVELVVCADATLLTNRAAML-GLPLTLRPYSPNSPAQPQT 69
           G+PAG+GP+LV + L+ R     L+  A   L+ +R  M  G+ +  R +     A P T
Sbjct: 11  GDPAGVGPELVAKVLSDRA----LLQKAHFILIADRDEMKKGMAIAGREFPWRDVAAPTT 66

Query: 70  A----GTLTLL--PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
           A    G   L+    +  AP   G+   ++G Y++ETL +A +   +G   A+   P++K
Sbjct: 67  ADLTVGEALLIHHRCSHPAPFEYGKATAQSGVYILETLKKALELTQSGLAQAICFAPLNK 126

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMML-ATEELRVALATTHLPLRDIADAITPALLH 182
             ++  G+ F     +F  +         +   + +    AT+H+P RDI   ++   + 
Sbjct: 127 QAMHMGGLAFRDELHWFAHQLDWTPFCCEVNVVDNVWAGRATSHIPFRDIVSNLSIDGVL 186

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
           + I ++H+ LR + G A PRI V  LNPH GE G  G EE   I P + + R QG+ + G
Sbjct: 187 DTITLMHNTLR-QAGFATPRIAVQALNPHGGENGLFGDEEQTIIRPAMEKARQQGINVFG 245

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
           P PADT ++    +  DAV++MYHDQ    LK  GF RGV +  GLP   T+ +HGTA  
Sbjct: 246 PYPADTTWKAMQTEKLDAVVSMYHDQFATALKMLGFERGVTVQGGLPVPITTANHGTAYN 305

Query: 303 LAGRGKADVGSFITALNLAIKMIVNTQ 329
           L G+  A   +F  A+ LAI+M   +Q
Sbjct: 306 LYGQNAATPSAFEQAVLLAIRMAKGSQ 332


>UniRef50_C2EXJ2 Putative uncharacterized protein (Fragment) n=4 Tax=Bacteria
          RepID=C2EXJ2_LACRE
          Length = 80

 Score =  160 bits (405), Expect = 5e-38,   Method: Compositional matrix adjust.
 Identities = 80/80 (100%), Positives = 80/80 (100%)

Query: 2  VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
          VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP
Sbjct: 1  VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 60

Query: 62 NSPAQPQTAGTLTLLPVALR 81
          NSPAQPQTAGTLTLLPVALR
Sbjct: 61 NSPAQPQTAGTLTLLPVALR 80


>UniRef50_B1GZF5 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=B1GZF5_UNCTG
          Length = 318

 Score =  160 bits (404), Expect = 8e-38,   Method: Compositional matrix adjust.
 Identities = 97/313 (30%), Positives = 154/313 (49%), Gaps = 13/313 (4%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           R+ IT G+PAG+G ++V +           VC+       ++    L   L+   P    
Sbjct: 5   RLAITLGDPAGVGCEIVCRAVSSSAVKR--VCSPVIFGDKQSLKRSLLKYLKNRMPFEFV 62

Query: 66  QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
           +    G      V + AP     +   +  Y      +A   C NG+  AL+T PV K  
Sbjct: 63  ESSNIGD----SVKMGAPSKKAGIIAASAIY------KAVKYCANGKALALVTAPVSKES 112

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
           +  +GI + GHTE     + +KKV MM+    +   + T H+P+  I++ I    + E +
Sbjct: 113 LKMSGIKYPGHTELLASLTNSKKVAMMMTCGNIHGVMVTRHIPVSKISENIKTKTIVEAV 172

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
            +  + LR K G    ++++CGLNPHAG+   +G EE   I+P    ++  G+ +  PL 
Sbjct: 173 NLSVNFLR-KAGKKNIKVVLCGLNPHAGDNSILGFEEKKFILPAYKIIKKSGIDITKPLS 231

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
           AD+ +        D + AMYHDQ +  LK     + VN+T+GLPF+RTS  HGTA  +AG
Sbjct: 232 ADSAWLKTKNGQYDLICAMYHDQIMIALKCINAAKIVNVTIGLPFVRTSPGHGTAFNIAG 291

Query: 306 RGKADVGSFITAL 318
           + +AD  + I A+
Sbjct: 292 KNEADASAMIEAI 304


>UniRef50_C3JBU1 4-hydroxythreonine-4-phosphate dehydrogenase n=5 Tax=Bacteria
           RepID=C3JBU1_9PORP
          Length = 371

 Score =  160 bits (404), Expect = 8e-38,   Method: Compositional matrix adjust.
 Identities = 93/236 (39%), Positives = 132/236 (55%), Gaps = 4/236 (1%)

Query: 94  GHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEER---SQAKKVV 150
           G    + L RA +  LN    AL+T P++K  +     PF GHT++   +    + +  +
Sbjct: 100 GRCAFDALERAMEDALNNRIDALVTAPINKATMPQDLFPFKGHTDYLGAKCGLKENESPL 159

Query: 151 MMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNP 210
           M+L + ++RVALATTH+ + ++A  ++ +LL E +  +   ++  F I +PRI V  LNP
Sbjct: 160 MILTSGDIRVALATTHVAISEVAGLLSESLLLEKLQAIESSMQRDFDIEKPRIAVLSLNP 219

Query: 211 HAGEGGHMGTEEIDTIIPVLNELRAQGMKLN-GPLPADTLFQPKYLDNADAVLAMYHDQG 269
           H+G+ G MG EEI+ I P L + R Q   L  GP  AD  +    L   DA+LA+YHDQG
Sbjct: 220 HSGDRGLMGREEIEIITPTLQKAREQHKLLAFGPFAADGFWGSAELYKYDAILALYHDQG 279

Query: 270 LPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
           L   K      GVN T GLP IRTS DHGT  ++AG+  A   S   A+ LAI  I
Sbjct: 280 LAPFKSLFMNEGVNFTAGLPIIRTSPDHGTGYDIAGKNLASSASLTAAIYLAIDTI 335


>UniRef50_A6C4H6 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Planctomyces
           maris DSM 8797 RepID=A6C4H6_9PLAN
          Length = 344

 Score =  158 bits (399), Expect = 3e-37,   Method: Compositional matrix adjust.
 Identities = 107/312 (34%), Positives = 150/312 (48%), Gaps = 15/312 (4%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + +T G+ +GIGP L+  L       ++   VV  +A +L   +   G  L +R     S
Sbjct: 6   IALTMGDVSGIGPQLLDVLCSGSEIFQICRPVVYGNAAVLRRASQQSGSQLQIREIESIS 65

Query: 64  PAQPQTAGTLTLLPVALR--APVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            +     G    +       A V   Q+   +G    + L  A D CL+GE  A+ T P+
Sbjct: 66  DSLEFRVGIANCIDRGNSNVAEVVPCQIDARSGQGAYDYLVSAIDDCLSGEMDAITTAPL 125

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMML---------ATEELRVALATTHLPLRDI 172
           +K  +  AGI + GHTE   +R       MML         +   L +   T H  +  +
Sbjct: 126 NKESLRLAGIDYPGHTEILADRCGVADYGMMLYLPHGAAIQSPAGLGIVHTTLHTSIASV 185

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
              ++   + E I ++   L  K G+A PR+ VC LNPHAGE G  G EE   I P + +
Sbjct: 186 PGLLSTDAIFEKIRLIS-GLMQKMGVAHPRVAVCALNPHAGEHGLFGDEEARIISPAVEQ 244

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
               G+   GPLPADTL +       DAV+AMYHDQG    K  GF + VNITLGLP +R
Sbjct: 245 AIQSGLDATGPLPADTLIRRAVRGEFDAVVAMYHDQGHIPFKLLGFDQAVNITLGLPIVR 304

Query: 293 TSVDHGTALELA 304
           TS  HGTA ++A
Sbjct: 305 TSPSHGTAFDIA 316


>UniRef50_B1IGV8 4-hydroxythreonine-4-phosphate dehydrogenase n=39 Tax=Bacteria
           RepID=PDXA_CLOBK
          Length = 334

 Score =  157 bits (397), Expect = 4e-37,   Method: Compositional matrix adjust.
 Identities = 96/329 (29%), Positives = 166/329 (50%), Gaps = 8/329 (2%)

Query: 1   MVKTQRVVITP-GEPAGIGPDLVVQL---AQREWPVELVVCADATLLTNRAAMLGLPLTL 56
           M+  + ++  P G+PAG+GP++VV+    A+       ++  DA ++        + L +
Sbjct: 1   MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNI 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRA--PVTAGQLAVENGHYVVETLARACDGCLNGEFA 114
                    +  T GT+ L+ +       +  G++    G    E + ++ +    GE  
Sbjct: 61  NSIKKADEGKF-TLGTIDLIDLNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELD 119

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
           A+ T P++K  + +  + + GHTE   + +  +  + M     +RV   T H+ LR   D
Sbjct: 120 AIATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEVRGMRVFFLTRHVSLRKACD 179

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +T   + + I      L  K G+ + ++ V GLNPH+GE G  G EE+  ++P + E +
Sbjct: 180 LVTKERVLDYIIRCSEALE-KLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQ 238

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
             G K+ GP+ AD++F        ++VL++YHDQG    K   F R + +T G+P +RTS
Sbjct: 239 KMGYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTS 298

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIK 323
           VDHGTA ++AG G+A   S + A+ LA K
Sbjct: 299 VDHGTAFDIAGTGQASSVSMVEAIVLAAK 327


>UniRef50_UPI00019F1502 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Citrobacter
           youngae ATCC 29220 RepID=UPI00019F1502
          Length = 336

 Score =  157 bits (397), Expect = 5e-37,   Method: Compositional matrix adjust.
 Identities = 104/327 (31%), Positives = 164/327 (50%), Gaps = 13/327 (3%)

Query: 12  GEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQ 68
           GE AGIGP+LV ++       +    ++  DA +L     + G+       +  S A+  
Sbjct: 12  GEAAGIGPELVAKVIADGTAYQYCKPIIIGDARVLALGQKIAGVSFPWETITDPSQAKWD 71

Query: 69  TAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
             GT+ L+ +    P  +  G +   +GH   E+L    +   +G+    +  P++K   
Sbjct: 72  N-GTVQLIDLKNYDPADLVMGTIDTVSGHATGESLITCMELLKSGKIDGFVFAPLNKEAF 130

Query: 127 NDAGIPFTGHTEFFEER----SQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
              G         F E+     + + ++ +L  ++L V   T H+P RDI   ITP  + 
Sbjct: 131 KKGGWHIEDEHYLFAEQLGCLDRPRGLLNVL--DDLWVFRVTGHVPFRDIVKYITPENVG 188

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
             + + +  LR   G   PRI V  LNPHAG+GG  GTEEID +IPV+ E RA+GM + G
Sbjct: 189 RSVQLCYDTLRMA-GYDNPRIAVAALNPHAGDGGTCGTEEIDVLIPVIEEYRAKGMDIYG 247

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
           P+P DTLF   +    DAV+ ++HDQG    K   F  GV +  GLP+  T+ +HGTA +
Sbjct: 248 PVPGDTLFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGVTVAGGLPYAITTPEHGTAFD 307

Query: 303 LAGRGKADVGSFITALNLAIKMIVNTQ 329
           +AG+G A   +   A+++A  M +  +
Sbjct: 308 IAGKGIAKTLATERAISVAANMALTNK 334


>UniRef50_Q0C095 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Alphaproteobacteria RepID=Q0C095_HYPNA
          Length = 335

 Score =  154 bits (390), Expect = 3e-36,   Method: Compositional matrix adjust.
 Identities = 105/260 (40%), Positives = 137/260 (52%), Gaps = 8/260 (3%)

Query: 76  LPVALRA---PVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIP 132
           LPV  R    PVT G+   +    ++ ++  A    L G   A++T P+HK ++   G  
Sbjct: 70  LPVLARGDARPVTPGKPDPDTAAGIITSIETATAHALAGIAGAVVTNPIHKALLYGQGFR 129

Query: 133 FTGHTEFFE-----ERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAI 187
           F GHTEF       +   A + VMML    LRVALAT H+P   +  A+    L  +  I
Sbjct: 130 FPGHTEFIASLCATDGGAAPEPVMMLTGGGLRVALATIHMPYTAVPAALADGRLQRIARI 189

Query: 188 LHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPAD 247
               L  +FGI  PRI   GLNPHAGE G +G EE++ I P   ELR +G+ ++   P D
Sbjct: 190 TAAALTRQFGIPAPRIAFTGLNPHAGEDGTIGREEVEIINPAAAELRNEGLDISDARPGD 249

Query: 248 TLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRG 307
           T+F        DAV+AM HDQGL  +K      GVN TLGLP IRTS DHGTA + A  G
Sbjct: 250 TVFAEALGGRFDAVIAMTHDQGLIPVKTLDMWGGVNTTLGLPIIRTSPDHGTAYDAAAAG 309

Query: 308 KADVGSFITALNLAIKMIVN 327
            A   S I A++ A +   N
Sbjct: 310 TAKADSLIAAIHSAREQAAN 329


>UniRef50_Q4FMQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Candidatus
           Pelagibacter RepID=Q4FMQ9_PELUB
          Length = 320

 Score =  154 bits (390), Expect = 3e-36,   Method: Compositional matrix adjust.
 Identities = 96/317 (30%), Positives = 148/317 (46%), Gaps = 8/317 (2%)

Query: 7   VVITPGEPAGIGPDLVVQ-LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN-SP 64
           ++I  GEP  I  ++  + L    +   L++     LL  +   L     +         
Sbjct: 6   IIIVGGEPNSIFLEIFFKSLKTNIYKSPLIIIISKKLLQEQMKKLDFYFKINDIDKELKD 65

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
               T   + L+ V  +      ++  ++  Y+ ET   A +       +  I GPV K 
Sbjct: 66  FSKLTNKKINLINVDYKFKKCFEKITSKSNKYIDETFKVALNFMKQNNLSKFINGPVSKK 125

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
                     G TE+  ++++ K V M++  + L V+  TTHL L+D+   IT   ++  
Sbjct: 126 SFLKGKT--LGITEYLAKKTKKKDVAMLIFNKNLSVSPLTTHLALKDVHKKITKQKIYTQ 183

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL 244
           + +++   +TKF    PRI + GLNPH  E     +EE   IIP + +LR +  K+NGP 
Sbjct: 184 VNLINKFYKTKFN-KLPRIAITGLNPHC-ESNFQNSEEDKVIIPAIKKLRLKNNKINGPF 241

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGL-PVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           PADT+F    L   D ++ MYHDQ L P+    GF   +NITLGLPF R S DHG    +
Sbjct: 242 PADTIFTKFLLKKYDVIIGMYHDQVLSPMKALFGFD-AINITLGLPFTRISPDHGPNYSM 300

Query: 304 AGRGKADVGSFITALNL 320
            G+  +D  S I AL  
Sbjct: 301 LGKNLSDPKSLIQALKF 317


>UniRef50_B2UL26 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Akkermansia
           muciniphila ATCC BAA-835 RepID=B2UL26_AKKM8
          Length = 289

 Score =  154 bits (390), Expect = 3e-36,   Method: Compositional matrix adjust.
 Identities = 100/253 (39%), Positives = 133/253 (52%), Gaps = 11/253 (4%)

Query: 78  VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHT 137
           +  R  +  G+   E+  +  + L +A      G   A++T PV K  +++AG  + G T
Sbjct: 38  IGKRVELPPGRPNAESAKHAFDHLEQAAHALREGTVDAVVTAPVCKETLHEAGFRWPGQT 97

Query: 138 EFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH--EVIAI--LHHDLR 193
           EFF ER +     M L  + L V LAT H  L+ +     P+LL   E++ I  L  D  
Sbjct: 98  EFFAERLKTDNYAMCLTGKRLTVGLATIHTSLQSV-----PSLLETEELVRIGTLLKDFC 152

Query: 194 TKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA--QGMKLNGPLPADTLFQ 251
            + GI  PRI +  LNPHAGE G  G E+ + I P +  LRA       +GP   D +++
Sbjct: 153 IRKGIMRPRIALAALNPHAGEHGAFGDEDGNIIAPAVERLRAIHPDAAFDGPSVPDCVYR 212

Query: 252 PKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADV 311
                N DAVLA YHDQGL  LK   F   VN+TLGLP  R S DHGTA  LAG GKA+ 
Sbjct: 213 DAVEGNYDAVLAPYHDQGLIPLKLVDFHTAVNVTLGLPRPRLSPDHGTAFNLAGTGKANP 272

Query: 312 GSFITALNLAIKM 324
            S I A  LA++M
Sbjct: 273 SSTIHAFQLAVQM 285


>UniRef50_A9LFJ9 Pyridoxal phosphate biosynthetic protein (Fragment) n=1 Tax=Karenia
           brevis RepID=A9LFJ9_KARBR
          Length = 254

 Score =  154 bits (388), Expect = 6e-36,   Method: Compositional matrix adjust.
 Identities = 96/246 (39%), Positives = 135/246 (54%), Gaps = 11/246 (4%)

Query: 81  RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGI-PFTGHTEF 139
           R  V AG+ A     +V E    A +  ++G    ++T P++K  + +AG   + GHTE 
Sbjct: 12  RVQVKAGRCATL---WVREATRLAVEKRIDG----IVTAPLNKQAMYEAGFTQYGGHTEI 64

Query: 140 FEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIA 199
            +E S AK   + L ++   VA  T H+P R+I+D + P  + E   IL   L+    + 
Sbjct: 65  LQEGSGAKSSSLCLYSDGFTVAHVTCHIPFREISDRLNPQKVFETTRILRDFLKMIHPMK 124

Query: 200 EPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG-PLPADTLFQPKYLDNA 258
           EPRI++ GLNPH       G EEI  I P +++  A G  ++  P+P DT+F        
Sbjct: 125 EPRIVMAGLNPHCEP--IFGDEEIRCIQPAIDDALALGWNVHRVPVPPDTVFLRTQRGEW 182

Query: 259 DAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITAL 318
           DAV+AMYHDQG    K  GF   VN+TLGLP IRTSVDHGTA  +AG G AD  +  +A+
Sbjct: 183 DAVVAMYHDQGHIPAKMGGFSNTVNVTLGLPIIRTSVDHGTAFNIAGTGTADESNLFSAI 242

Query: 319 NLAIKM 324
           +L   M
Sbjct: 243 HLCTTM 248


>UniRef50_Q2KXH9 4-hydroxythreonine-4-phosphate dehydrogenase n=9 Tax=Bacteria
           RepID=Q2KXH9_BORA1
          Length = 348

 Score =  153 bits (387), Expect = 7e-36,   Method: Compositional matrix adjust.
 Identities = 104/322 (32%), Positives = 154/322 (47%), Gaps = 6/322 (1%)

Query: 9   ITPGEPAGIGPDLVVQLAQR----EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           +T G+ AGIGP++  ++  +         LVV  D  ++T     LG    +      + 
Sbjct: 12  VTLGDVAGIGPEITAKMLMKHDALRQKARLVVIGDVDVMTEAVRRLGGDPAIVRRVERTA 71

Query: 65  AQPQTAGTLTLLPVALR-APVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
               T GT+ +       A V  G+++   G   V  +  AC     GE   ++T P++K
Sbjct: 72  DVSNTPGTIEVYQAGPSLAGVKLGEISAAAGDGSVRFVTTACALARAGEVDGIVTAPLNK 131

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             ++ AG  + GHTE        K   ++L+  +L +  ATTH+ LR   + +TPA +  
Sbjct: 132 AAMHAAGHKWPGHTELLAHEFGVKTFSLVLSAGDLYIFHATTHVSLRQAIEDLTPARVRA 191

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
           V+  L        G  +  + V GLNPHAGE    G E+ D + P + E  A G+   GP
Sbjct: 192 VLR-LAGSFAKALGRGDQPVAVSGLNPHAGENRIFGDEDADILAPAVAEANADGILAAGP 250

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           +PAD LF          V+A YHDQG    K      GVNIT+GLP +R SVDHGTA ++
Sbjct: 251 IPADALFPQAVRGKWQFVIACYHDQGHAPFKSVYGDDGVNITVGLPVVRVSVDHGTAFDI 310

Query: 304 AGRGKADVGSFITALNLAIKMI 325
           AG+G A   S + A   A  ++
Sbjct: 311 AGQGIAREDSLVLAAERAAALV 332


>UniRef50_Q04UJ6 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Leptospira
           RepID=Q04UJ6_LEPBJ
          Length = 316

 Score =  152 bits (385), Expect = 1e-35,   Method: Compositional matrix adjust.
 Identities = 111/332 (33%), Positives = 168/332 (50%), Gaps = 40/332 (12%)

Query: 5   QRVVITPGEPAGIGPDLVVQ---LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           +R++IT G+P GIGP++ V    L ++   +  +V   +            PL     S 
Sbjct: 2   KRILITEGDPCGIGPEIFVHSLFLLRKISKIRPIVYFHSG---------KFPLPKEFVSI 52

Query: 62  NSPAQPQTAGTLTL----LPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
           +S ++    G   +    L     + +  G+ +  +G   +  L  + +    G    LI
Sbjct: 53  SSSSEILKKGLFAIGHDSLSKKEVSSLKFGRPSALSGKSALAALVLSIEFQKEGG-GDLI 111

Query: 118 TGPVHKGVINDAGIP-FTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
           T P+ K  +  +G+  F GHTEF  E  + K   M+++  +L+V   TTH+PL  +    
Sbjct: 112 TLPLSKEWVIASGVSTFRGHTEFLAEAYRTK-TFMLMSGNDLQVLPLTTHIPLVKV---- 166

Query: 177 TPALLHEVIAILHHDLRT---------KFGIAEPRILVCGLNPHAGEGGHMGTEEIDTII 227
            P  L E+      DL++         K  + +P I   GLNPHAGEGG +G EE + ++
Sbjct: 167 -PEFLKEI------DLKSLANSILSCEKIDLQKP-IAFLGLNPHAGEGGKIGKEEEEILV 218

Query: 228 PVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLG 287
           P++  L+ QG+K+ GPL AD++F           LA YHDQGL   K     +GVN+TLG
Sbjct: 219 PMIRSLKRQGLKVEGPLSADSVFGESARKKFGLHLACYHDQGLIPFKMWEGKKGVNLTLG 278

Query: 288 LPFIRTSVDHGTALELAGRGKADVGSFITALN 319
           LPFIR S DHGTA ++AG+G AD  SF+  LN
Sbjct: 279 LPFIRVSPDHGTAFDIAGKGLADSTSFMECLN 310


>UniRef50_Q9CKG8 4-hydroxythreonine-4-phosphate dehydrogenase n=3
           Tax=Gammaproteobacteria RepID=PDXA_PASMU
          Length = 337

 Score =  151 bits (382), Expect = 3e-35,   Method: Compositional matrix adjust.
 Identities = 100/328 (30%), Positives = 165/328 (50%), Gaps = 14/328 (4%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           V +T G+PAGIGP+LV +L  ++   E   +V+ AD   L     +          S + 
Sbjct: 6   VALTLGDPAGIGPELVAKLLAKQNIREKANIVLVADKDELEKGMEIAKAQFVYEEVSFHQ 65

Query: 64  PAQPQTAGTLTLLPVALR------APVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
             Q +     T +PV +        P   G++  ++G Y++ETL  A +    G   A+ 
Sbjct: 66  LGQYEFK---TGVPVLISHKSSHPKPFEYGKVTEQSGVYILETLKVALNLAKMGYVQAIC 122

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMML-ATEELRVALATTHLPLRDIADAI 176
             P++K  ++  G+ +     +F E++   + V  L   +++  A  T+H+P +DI   +
Sbjct: 123 FAPLNKQAMHKGGLRYRDELHWFAEQTDFNEFVCELNVVDDIWAARVTSHIPFKDIVPNL 182

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           +   + + I +L+  L  + G+  P+I V  LNPH GEGG  G EE+  I P + + R  
Sbjct: 183 SIKGVFDCIHLLYRSL-VQAGVENPKIAVQALNPHGGEGGVFGDEEMTIIQPGMEQARKA 241

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G+ + GP P DT  +       + V++MYHDQ    LK  GF RGV +  G+P   T+ +
Sbjct: 242 GIDVYGPFPGDTTMREVERLKINGVVSMYHDQFSTALKILGFERGVTVQGGIPIPITTAN 301

Query: 297 HGTALELAGRGKADVGSFITALNLAIKM 324
           HGTA +L G+  A   +F  A N+A++M
Sbjct: 302 HGTAFDLHGKNIAIPTAFEAAFNIAVRM 329


>UniRef50_C5CPN5 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Variovorax
           paradoxus S110 RepID=C5CPN5_VARPS
          Length = 354

 Score =  150 bits (380), Expect = 5e-35,   Method: Compositional matrix adjust.
 Identities = 104/327 (31%), Positives = 166/327 (50%), Gaps = 12/327 (3%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           R+ +  G+P GIGP++ V+L  R+  ++   +++ AD  +L     + G+ L   P   +
Sbjct: 16  RIAVLLGDPGGIGPEMAVKLLARQRNLDAARVLLIADPVVLAAGERVAGVKLD--PLRID 73

Query: 63  SPAQPQTA-GTLTLLP---VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                +   G  TLL    +  R PV  G+    +G    E L  A      G+   ++ 
Sbjct: 74  GLDDLRFEHGRPTLLQRDWMQGREPVL-GESNEASGRASFEALELATAAVRRGQAEGIVF 132

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLA-TEELRVALATTHLPLRDIADAIT 177
            P++K  +   G+       + +ER      V     T  L  +  T+H+PL+D+A  IT
Sbjct: 133 APLNKHSLRLGGLVHEDELRYMQERFAVTGFVCEFNLTGSLWTSRVTSHIPLKDVASHIT 192

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              + + + I+   LR + G+A+PRI V GLNPHAG+GG +G EEI+ I P +  LRA+G
Sbjct: 193 VEGVGDAVKIIASALR-RAGVAQPRIAVTGLNPHAGDGGSIGMEEIEIIAPAIERLRAEG 251

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
               GP   DT+F      + DAV++MYHDQG   +K  GF +GV +  GLP    +   
Sbjct: 252 YDARGPFSPDTVFIGARRGDVDAVVSMYHDQGQIAMKLMGFEQGVTLHGGLPVPVATSAS 311

Query: 298 GTALELAGRGKADVGSFITALNLAIKM 324
           G+A ++AG+G A +     A +L ++M
Sbjct: 312 GSAFDIAGKGVAQIEGLQQAFDLCVRM 338


>UniRef50_C3XMM1 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Helicobacter
           RepID=C3XMM1_9HELI
          Length = 317

 Score =  149 bits (377), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 112/335 (33%), Positives = 171/335 (51%), Gaps = 41/335 (12%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWP-VELVVCADATLLTNRAAMLG--LPLTLRPYSPN 62
           ++ ++ G+P G+G +++++  ++       V C D  LL   A +L   LP  L+  SP 
Sbjct: 2   KIAVSIGDPNGVGLEILLKNHKKICKFCNPVYCVDKELLKEAAKILKFKLPKNLKCVSPK 61

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
                       ++P  +   +T G +  E+G Y   +  +A +  L G+  A++T P+H
Sbjct: 62  ------------VMPSNIIPKITPGAIQKESGAYSYASFLQALNLTLVGKTKAMVTLPIH 109

Query: 123 KGVINDAGIPFTGHTEF------FEERS------QAKKVVMMLATEELRVALATTHLPLR 170
           K     AG+ + GHTE       FE         Q +K +MML + +L VAL + H+PL+
Sbjct: 110 KKAWQLAGVSYAGHTEALRDVFKFENMESKINGIQNQKAIMMLGSPKLYVALFSDHIPLK 169

Query: 171 DIADAITPALLHE-VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEE--IDTII 227
           ++   I    L E ++    + L+   G       V GLNPHAG+ G +G E+  I   I
Sbjct: 170 NVPSLINIESLKEFLLDFAPYVLKMPCG-------VLGLNPHAGDFGVLGDEDNVIREAI 222

Query: 228 PVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLG 287
            + N    + + + GPL  DT F  K+L      +AMYHDQGL  LK   F   +NITL 
Sbjct: 223 RLANASLGKEVFI-GPLVPDTAFVGKHLR---YYVAMYHDQGLIPLKTLYFKESINITLN 278

Query: 288 LPFIRTSVDHGTALELAGRGKADVGSFITALNLAI 322
           LP IRTSVDHGTA ++A + KA+  S+I A+  AI
Sbjct: 279 LPVIRTSVDHGTAFDIAYKNKAESKSYINAIKEAI 313


>UniRef50_Q30S58 4-hydroxythreonine-4-phosphate dehydrogenase n=11
           Tax=Epsilonproteobacteria RepID=PDXA_SULDN
          Length = 307

 Score =  149 bits (377), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 103/322 (31%), Positives = 157/322 (48%), Gaps = 26/322 (8%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS-PNSP 64
           R+ I+ G+  G+G ++ ++ A  E      +CA   L    + ML    TL  Y  P++ 
Sbjct: 5   RIAISVGDLNGVGIEIAIK-AHEEVSK---LCA--PLYCINSYMLNQASTLLNYKIPSNF 58

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
              +  G            V  G +  ++G Y  ++   A   C   +  A++T P+HK 
Sbjct: 59  EISEVGGEFA---------VKKGCVDKDSGRYSYDSFIHAISLCEQKKADAVVTMPIHKE 109

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
               AG+ + GHT+   E  + +  +MML  +++ VAL + H+PL+D+A +I    L + 
Sbjct: 110 AWMLAGLKYKGHTDLLREHFK-RDAIMMLGCQKMFVALFSEHIPLKDVASSIKYKKLKQF 168

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEE--IDTIIPVLNELRAQGMKLNG 242
                  L     +   R+ V GLNPHAG+ G +G EE  I   I   N+ +    +  G
Sbjct: 169 F------LDFNNSVPNERVAVLGLNPHAGDNGVLGNEELIITKAIKSANK-KVCFEQFIG 221

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
           PL  D  F P   +     +AMYHDQGL  LK   F   +N++L LP IRTSVDHGTA +
Sbjct: 222 PLVPDIAFTPHIREKFKYFIAMYHDQGLAPLKALYFDESINVSLNLPIIRTSVDHGTAFD 281

Query: 303 LAGRGKADVGSFITALNLAIKM 324
           +A   KA   S+I A+  AI +
Sbjct: 282 IAYEKKAKTLSYINAIKSAIAL 303


>UniRef50_Q17ZN0 4-hydroxythreonine-4-phosphate dehydrogenase n=16
           Tax=Epsilonproteobacteria RepID=PDXA_HELAH
          Length = 310

 Score =  149 bits (376), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 98/324 (30%), Positives = 165/324 (50%), Gaps = 27/324 (8%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPV--ELVVCADATLLTNRAAMLGLPLTLRP 58
           MVK +++ I+ G+  GIG +L+++ + +E  V  E +    + LL     +L     ++P
Sbjct: 1   MVK-KKIAISCGDIQGIGLELILK-SHKEVSVLCEPLYLIHSELLGRANQLLTNAYEVKP 58

Query: 59  YSP---NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
            +    NSP     + T+             G+++ ++G Y  E+  +AC+   + E  +
Sbjct: 59  LNAIAINSPLPSFNSSTI-------------GKVSAQSGAYSFESFRKACELADDKEVDS 105

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           + T P++K     A IPF GHT+F ++R +  +++MML   +L V L + H+PLR ++  
Sbjct: 106 ICTMPINKLAWQQAQIPFVGHTDFLKQRYKEHQIIMMLGCPKLFVGLFSDHVPLRAVSQL 165

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           I      +V A++   L  +       I VCG NPHAGE G  G E+   +  +    + 
Sbjct: 166 I------QVKALVQFLLAFQKSTQAQIIQVCGFNPHAGEEGLFGEEDEKILKAIQESNQT 219

Query: 236 QGMK-LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
            G +   GPLPAD+ F P         ++M HD GL  LK   F   +N++L  P +R S
Sbjct: 220 LGFECFLGPLPADSAFAPNKRQITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRAS 279

Query: 295 VDHGTALELAGRGKADVGSFITAL 318
            DHGTA ++A + KA+  S++ A+
Sbjct: 280 TDHGTAFDIAYQNKANNKSYLNAI 303


>UniRef50_Q3V7R5 Pyridoxal phosphate biosynthetic protein n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q3V7R5_BDEBA
          Length = 316

 Score =  148 bits (374), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 91/230 (39%), Positives = 131/230 (56%), Gaps = 7/230 (3%)

Query: 98  VETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE 157
           VE  A+AC   L  E  AL T P+ K  I  AG    GHT+  +  S AK V M    E+
Sbjct: 88  VELSAKAC---LKKEIHALATAPLSKTSIKAAGFKDLGHTDILKRLSGAKHVHMGFVGEK 144

Query: 158 LRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPR--ILVCGLNPHAGEG 215
             V LAT HLP+++I   ++ ++L E + +  ++LR K   ++ +  I V GLNPHAGE 
Sbjct: 145 FNVVLATAHLPVKEITKHLSFSVLAEAL-LNANELRKKLPASQAKKPIGVLGLNPHAGEA 203

Query: 216 GHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGL-PVLK 274
           G +G EE+     +++  + + +   GPL  D  F P+        L++YHDQGL P   
Sbjct: 204 GLIGQEELLFFPELVSFAKEKKIPFEGPLVPDAAFFPQNWKKYSVYLSLYHDQGLIPFKM 263

Query: 275 YQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
             G   GV++TLG+PFIRTSVDHGTA ++ G+ KA+  S I A+  A+K+
Sbjct: 264 IHGQDSGVHMTLGIPFIRTSVDHGTAKDIFGKNKANPHSMIDAVRWAVKL 313


>UniRef50_Q390F1 4-hydroxythreonine-4-phosphate dehydrogenase n=22
           Tax=Proteobacteria RepID=Q390F1_BURS3
          Length = 351

 Score =  148 bits (373), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 101/331 (30%), Positives = 157/331 (47%), Gaps = 16/331 (4%)

Query: 7   VVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRPYSP-- 61
           V +T G+PAGIG +L+ +L  R        LV+  D  L      + G+ + + P +   
Sbjct: 13  VALTLGDPAGIGAELIAKLLARPDATTHANLVLIGDRWLWEAGQRVAGVTVDVEPVASLA 72

Query: 62  ---NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
              N P+  + A     +     A VT GQ     G   +  L    D  L G+  A+  
Sbjct: 73  AVRNRPSTARAA--FVAIDTIDPADVTVGQPGAAGGRSTLTVLDLCLDAALAGDIDAICF 130

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLAT-EELRVALATTHLPLRDIADAIT 177
            P++K  +   G+        F E            T  EL  A  ++H+PL+D    ++
Sbjct: 131 APLNKYAMKLGGLKHEDELHHFAEALGVTGYFCEFNTLGELWTARISSHIPLKDAPGYLS 190

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              + +   +++  L    G+A P++ +   NPH G+GG  G EE+D I P + +L+++ 
Sbjct: 191 IERIEQASELIYRSLLAN-GVAAPKVAIAAFNPHGGDGGSCGREEVDIIEPAVRQLQSRD 249

Query: 238 MK----LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
                  +GP PADT+F      +  A++ MYHDQG   +K  GF RGV +  GLP   T
Sbjct: 250 WPTDAPFHGPFPADTIFLKAQAGDYQAIVTMYHDQGQIAIKLLGFSRGVTVQGGLPVPIT 309

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIKM 324
           +  HGTA ++AGRG ADVG+   AL +A +M
Sbjct: 310 TPAHGTAYDIAGRGTADVGATWQALQIACRM 340


>UniRef50_A5GHP5 4-hydroxythreonine-4-phosphate dehydrogenase n=11 Tax=Cyanobacteria
           RepID=A5GHP5_SYNPW
          Length = 342

 Score =  147 bits (372), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 118/338 (34%), Positives = 172/338 (50%), Gaps = 26/338 (7%)

Query: 4   TQRVVITPGEPAGIGPDLVVQ-LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
            Q +VI  G+PAGIG ++ ++ LA    P  +       L+  RA++      LR  +  
Sbjct: 11  NQHLVIALGDPAGIGMEVTLKALAHPRCPEGM----KPLLVGCRASLKRTHQRLRNLTGV 66

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
             A P     +  LP+   APV  G      G      L+RA +    G   AL+T P+ 
Sbjct: 67  PLADPDDL-DVEDLPIP-GAPVNPGDAGAAGGAAGFRWLSRAVELVQAGHGRALVTAPIA 124

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLAT------EELRVALATTHLPLRDIADAI 176
           K   + AG P+ G TE   E  +A+   M+           L   LATTH+PL+ ++ A+
Sbjct: 125 KHTWHAAGHPYPGQTERLAELDRAESASMLFTAVSPSTGWRLNTLLATTHIPLQQVSQAL 184

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           TPAL+   +  L    + +F    P +LV GLNPHAGE G +G+EE   + P+L++  AQ
Sbjct: 185 TPALVRSKLETLTRFCQ-RFN-PSPELLVAGLNPHAGEKGQLGSEEEQWLTPLLHQW-AQ 241

Query: 237 G---MKLNGPLPADTLF----QPKYLDNA---DAVLAMYHDQGLPVLKYQGFGRGVNITL 286
               ++L GPLP DT +    Q     +A   D +LA+YHDQGL  +K   F + VN TL
Sbjct: 242 ANPTIRLKGPLPPDTCWLSAAQAWNRSDASGPDGILALYHDQGLIPVKLLAFDQAVNTTL 301

Query: 287 GLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           GL F+RTS DHGT  ++A +G A   S ++A+  A  +
Sbjct: 302 GLSFLRTSPDHGTGFDIAAQGIARCESMLSAIEAAWTL 339


>UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=10
           Tax=Proteobacteria RepID=PDXA2_PSEAE
          Length = 337

 Score =  147 bits (372), Expect = 4e-34,   Method: Compositional matrix adjust.
 Identities = 107/334 (32%), Positives = 168/334 (50%), Gaps = 24/334 (7%)

Query: 6   RVVITPGEPAGIGPDLVVQL---AQREWPVELVVCADATLLTNRAAMLGLPLTLR----- 57
           R+ +  G+PAGIGP+L+ +L    +      +V+ AD   +     + G     R     
Sbjct: 8   RLAMVLGDPAGIGPELIARLLADTEVREKAHIVLIADEAEMRRGMRIAGCEFPYRRIDAL 67

Query: 58  ---PYSPNSPA-QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEF 113
               ++  +P   P  +      P +  + V         G Y +ETLA A +   +G  
Sbjct: 68  ETLDFADATPLLHPWLSQGGDEFPRSEASAV--------GGRYSLETLALALELTRSGRT 119

Query: 114 AALITGPVHKGVINDAGIPFTGHTEFFEER-SQAKKVVMMLATEELRVALATTHLPLRDI 172
            A++ GP++K  ++ AG+  +    +F ER             ++L  +  T+H+ L ++
Sbjct: 120 DAILFGPLNKTSLHMAGMDHSDELHWFAERLGFGGPFCEFNVLDDLWTSRVTSHVALAEV 179

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
              ++   + E I ++   LR + G+A PRI VCGLNPH G+ G  G EE+D I P + +
Sbjct: 180 PGLLSQERVGEAIRLIDDALR-RSGLARPRIGVCGLNPHNGDNGSFGREELDIIAPAVQK 238

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNA--DAVLAMYHDQGLPVLKYQGFGRGVNITLGLPF 290
            R QG+  +GP PADT+F     D    DAV+ MYHDQG   +K  GF RGV +  GLP 
Sbjct: 239 AREQGIAADGPYPADTIFLKVQGDARAFDAVVTMYHDQGQIAIKLMGFSRGVTVQGGLPI 298

Query: 291 IRTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
              +  HGTA ++AG+G+ADVG+   A  +A +M
Sbjct: 299 PIATPAHGTAFDIAGQGRADVGATRQAFEIACRM 332


>UniRef50_B8FR92 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Desulfitobacterium hafniense RepID=B8FR92_DESHD
          Length = 342

 Score =  146 bits (369), Expect = 9e-34,   Method: Compositional matrix adjust.
 Identities = 94/326 (28%), Positives = 162/326 (49%), Gaps = 17/326 (5%)

Query: 9   ITPGEPAGIGPDLVVQ------LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           +T G+PAG+GP++V +      LA+   P+   +  D  L      +  + +  +  +  
Sbjct: 12  VTMGDPAGVGPEIVAKAAAQGILAKDAHPI---IVGDQRLFKRGMEIAKVRVDFQVAATL 68

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
             A       +        A +  G+L  E G      +      C  G    +   P +
Sbjct: 69  EEALTMDGIVVLDTRKFDAADLVMGELREECGRDAATNIQTCVQYCRQGLMDGICFAPNN 128

Query: 123 KGVINDAGIPFTGHTE----FFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           K  +  AG    G  +    FF+      ++ ++   +++  A  T+H+P++DI+  +T 
Sbjct: 129 KAAMKKAGFVLHGAIDLLAGFFQFTGNRGELNVL---DDVWTARVTSHIPVKDISARLTE 185

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             +   I +++  L+ + GIA+PRI V  LNPH GEGG  G EE++ I P + + +A G+
Sbjct: 186 EGILNSIHLVNDTLK-RAGIAKPRIAVAALNPHGGEGGTCGREEVEVIAPTVEKAKAMGI 244

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           + +GP PADTLF   +    DA + M+HDQG   +K +GF +GV +  GLP   T+  HG
Sbjct: 245 ETDGPFPADTLFIKLFNREYDAAVTMFHDQGQIAMKLKGFDQGVTVMAGLPNPVTTCSHG 304

Query: 299 TALELAGRGKADVGSFITALNLAIKM 324
           +A ++AG+G A+ G++  +  L +KM
Sbjct: 305 SAFDIAGKGIANPGAWGNSYGLVVKM 330


>UniRef50_A8S524 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8S524_9CLOT
          Length = 334

 Score =  146 bits (369), Expect = 9e-34,   Method: Compositional matrix adjust.
 Identities = 99/321 (30%), Positives = 156/321 (48%), Gaps = 33/321 (10%)

Query: 12  GEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQ 68
           G+ AG+GP+++V+LA   +  E    VV  D  +    A + GL + ++        + +
Sbjct: 12  GDAAGVGPEIIVKLAASRFYDEYCRPVVIGDVRVFERGARICGLEIPVQVID-----KVE 66

Query: 69  TAGTLTLLPVALRAPVTAGQ-----LAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A     +PV  +  V   Q     +++E+G   +  L  A +    G        P++K
Sbjct: 67  EADWTKGMPVLDQRDVDPEQVPFANISIESGRACLNMLKTAIELYQAGRIDGFCFAPLNK 126

Query: 124 GVINDAGIPFT----------GHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIA 173
             +  AG PF           GHTE F E       + +L   +L     T+H+P+  ++
Sbjct: 127 QAMIQAGCPFESEHHYMAHLFGHTEPFGE-------INVLG--DLWTTRTTSHIPISKVS 177

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL 233
           D++T   +   I + +  L+   GI +PR+ +  LNPH GEGG  G EEID I P + + 
Sbjct: 178 DSLTVDTIMRAIRLANVSLKNS-GIEKPRLALAALNPHCGEGGKCGREEIDVIAPAIEKA 236

Query: 234 RAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
           R  G+  NGP P+D LF   +  + D V+ MYHDQG   LK +GF +G+ I  GLP    
Sbjct: 237 REMGIDANGPFPSDILFIKAFNGDFDGVVTMYHDQGQIALKLKGFDQGITIAGGLPAPIV 296

Query: 294 SVDHGTALELAGRGKADVGSF 314
           +  HGTA ++AG+G     +F
Sbjct: 297 TCAHGTAYDIAGKGIVKTSAF 317


>UniRef50_D0RQA4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=alpha
           proteobacterium HIMB114 RepID=D0RQA4_9RICK
          Length = 329

 Score =  146 bits (368), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 97/330 (29%), Positives = 162/330 (49%), Gaps = 10/330 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPVE--LVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           ++V +  G+P+GIGP+LVV+L   +   E  +VV  +  +L +   + G  +  +  +  
Sbjct: 3   KKVAVLLGDPSGIGPELVVRLLNEDISNEANVVVIGEKKILEDGENISGKKVDFKFVTDF 62

Query: 63  SPAQPQTAGTLTL-LPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           +  +        L +          G+++ E+G  V+E +  A D     +  A+  GP+
Sbjct: 63  NEVKFNDKTKFFLDISKGTNRTYKRGEVSAESGKSVLEAMDYALDLAKEKKIDAINFGPM 122

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMML-ATEELRVALATTHLPLRDIADAITPAL 180
           +K  +   G  +    +F + + + K+        +    A  T+H+P++++ + IT   
Sbjct: 123 NKTSLMMGGCQYNDEHDFMQNKLEMKEFCCEFNVVDNFWTARVTSHIPIKEVPENITKEN 182

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           + + I +L   L+   GI  PRI V  LNPHA      GTEE D IIP + E +  G+  
Sbjct: 183 ILKPIKLLDQTLKMS-GIKNPRIAVQALNPHA----EFGTEEKDEIIPAIEEAKKMGINA 237

Query: 241 NGPLPADTLFQPKYLD-NADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           +GPLP DT F   + + N D ++ MYHD     LK  GF RGV ++ GL    T+  HGT
Sbjct: 238 DGPLPCDTSFITAFKNKNHDCIVGMYHDALQCGLKAFGFDRGVTVSGGLTVPVTTPAHGT 297

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           A ++ G   A++   I +  LA+KM   TQ
Sbjct: 298 AFDIVGTNTANLEPTINSFKLAVKMNSGTQ 327


>UniRef50_Q92TP3 4-hydroxythreonine-4-phosphate dehydrogenase 3 n=8 Tax=Rhizobiales
           RepID=PDXA3_RHIME
          Length = 348

 Score =  145 bits (366), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 107/327 (32%), Positives = 161/327 (49%), Gaps = 14/327 (4%)

Query: 7   VVITPGEPAGIGPDLVVQL---AQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + +  G+PAGI P+L  +L   +       ++   D  +L   A + G+ L L   S ++
Sbjct: 16  IALAMGDPAGISPELTARLLALSDIRDAAHIIAIGDRRILDEGARVAGVTLDLEAASLDA 75

Query: 64  PAQPQTAGTLTLLPVALR----APVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
                 AGT   + V L     A V  G+  +  G +       A +    G+  A+   
Sbjct: 76  L---DNAGTARHVFVDLAHLDPADVVRGEATLAGGTFATRNFRTALELAHAGKADAVCFT 132

Query: 120 PVHKGVINDAGIPFTGHTEFFEE-RSQAKKVVMMLATEELRVALATTHLPLRDIADAIT- 177
           P +K  +  A   +     F  +  S   KV      E++  A  T+H+PL+D+A  ++ 
Sbjct: 133 PFNKKAMRFAYPGYDDEIRFVADVLSFTGKVREFNVLEKVWNARVTSHIPLKDVASHLSV 192

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
            A+L E+   L        G  E +I V GLNPHAG+GG  G EEID I P + + RA G
Sbjct: 193 EAILAELK--LTQACLKDAGYEEAKIAVAGLNPHAGDGGSFGMEEIDIIEPAVEKARALG 250

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
             + GP PADT+F     +  +AV+ MYHDQG   +K  GF +GV +  GLPF   +  H
Sbjct: 251 FNVEGPFPADTVFLRALKEGFNAVMTMYHDQGQIAMKIIGFDKGVTMMGGLPFPLCTPAH 310

Query: 298 GTALELAGRGKADVGSFITALNLAIKM 324
           GTA ++AG+G AD+G+   A+ LA +M
Sbjct: 311 GTAYDIAGKGIADIGATREAILLAARM 337


>UniRef50_Q31DF6 4-hydroxythreonine-4-phosphate dehydrogenase n=8
           Tax=Prochlorococcus marinus RepID=Q31DF6_PROM9
          Length = 343

 Score =  142 bits (358), Expect = 2e-32,   Method: Compositional matrix adjust.
 Identities = 111/346 (32%), Positives = 171/346 (49%), Gaps = 40/346 (11%)

Query: 6   RVVITPGEPAGIGPDLVVQ-LAQREWP--VELVVCADATLLTN---RAAMLGLPLTLRPY 59
           ++V++ G+ +GIGP+++++ L   E P  ++ V+      L N   +   LGL     P 
Sbjct: 11  KLVLSVGDESGIGPEIILKALYSNEIPENIDFVIVGSKKNLQNTYRKLKSLGLENLANPK 70

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
           + N          +  L ++     ++       G      L +A +       +AL+TG
Sbjct: 71  NLN----------IHDLEIS-----SSDDSKASYGDSSFNYLTKAIEIVKQYPNSALVTG 115

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE------LRVALATTHLPLRDIA 173
           P+ K   + AG  F+G TE   +    K V M+   +       L   LATTH+ L ++ 
Sbjct: 116 PICKKSWSLAGHYFSGQTEVLAKSCGVKNVGMLFTAKSPITGWRLNTLLATTHIALCEVP 175

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVL--- 230
             +T  L+H  +  L  D  + + + +P   V GLNPHAGE G +G EE D +   L   
Sbjct: 176 KKLTTELIHSKLD-LFKDFCSTY-VDKPSFKVSGLNPHAGEEGLLGNEEKDWLNDALIAW 233

Query: 231 NELRAQGMKLNGPLPADTLFQP--KYLDNADA-----VLAMYHDQGLPVLKYQGFGRGVN 283
           NE   + +KL GPL  D+ +    K   N DA     +LAMYHDQGL  +K       VN
Sbjct: 234 NE-NNRDIKLLGPLSPDSCWNSSAKAWRNKDAEKHDGILAMYHDQGLIPMKVIALNYSVN 292

Query: 284 ITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           +T+GLPFIRTS DHGT  ++AG+G A+  S I A+  AI+M  +++
Sbjct: 293 MTIGLPFIRTSPDHGTGFDIAGKGIAESQSMIEAIITAIEMTKSSR 338


>UniRef50_Q0RWE6 Terephthalate dihydrodiol dehydrogenase n=2 Tax=Bacteria
           RepID=Q0RWE6_RHOSR
          Length = 338

 Score =  140 bits (354), Expect = 4e-32,   Method: Compositional matrix adjust.
 Identities = 120/327 (36%), Positives = 168/327 (51%), Gaps = 25/327 (7%)

Query: 6   RVVITPGEPAGIGPDLVVQ--LAQREWPV-ELVVCADATL---LTNRAAMLGLPLTLRPY 59
           RV++T G+P GIGP+L V+  +A +E P    V+  D  +   L +RA M     T+R  
Sbjct: 7   RVLLTIGDPNGIGPELAVKAVMAAQEHPAFNPVLVGDRCVVEPLAHRAGM-----TVR-E 60

Query: 60  SPNSPAQPQTAGTLTLLPV-ALRAPVTA-GQLAVENGHYVVETLARACDGCLNGEFA-AL 116
           + +  A P  A  + LLPV +L A   A G++  E G   V  L RA   CL G  A  +
Sbjct: 61  TADGLATPM-ADVVDLLPVPSLPAGAFAPGRVTAEAGKATVAYLERAVR-CLQGGGARGI 118

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAK--KVVMMLATEELRVALATTHLPLRDIAD 174
           +  P  +  +N AGI F G+     E   A+  +V +ML    LR+  AT H  LRD   
Sbjct: 119 VACPHSETAVNAAGISFDGYPSLLAELVGARPDQVFLMLIGAGLRIVHATLHESLRDALG 178

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +TP L+H         L+ + GI  PRI V G+NPHAGEGG  G E++    P +  LR
Sbjct: 179 RLTPELVHGAARAAVETLQAQ-GIPSPRIGVFGINPHAGEGGLFGDEDLRVTTPAVERLR 237

Query: 235 AQGMKLNGPLPAD-TLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
           A G+  +GP+ AD  L  P +    DA +AMYHDQG   +K         +T+G     +
Sbjct: 238 AAGIDASGPVGADLMLADPGF----DAFVAMYHDQGHIPVKLLAGRSAAAMTIGAGVRFS 293

Query: 294 SVDHGTALELAGRGKADVGSFITALNL 320
           SV HG   ++AG+G AD  + + AL L
Sbjct: 294 SVGHGAGFDIAGKGTADPDAVVGALRL 320


>UniRef50_A1RD08 Pyridoxal phosphate biosynthetic protein n=2 Tax=Actinomycetales
           RepID=A1RD08_ARTAT
          Length = 322

 Score =  134 bits (337), Expect = 4e-30,   Method: Compositional matrix adjust.
 Identities = 100/321 (31%), Positives = 154/321 (47%), Gaps = 14/321 (4%)

Query: 6   RVVITPGEPAGIGPDLVVQLA---QREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           R ++  G+P GIGP+L V+ A   Q +     VV  D  ++ + A+  GL +        
Sbjct: 5   RTLLPIGDPNGIGPELAVRAAAEMQAQGSEPPVVVGDRFVVAHYASRFGLSIR----ETI 60

Query: 63  SPAQPQTAGTLTLLPVALRAPV--TAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
             A+P    T+ LLPV    P     G++    G   VE +  A     +G  +A++  P
Sbjct: 61  GTAEP-IMHTVDLLPVDAMPPAEFKPGRVCAAAGRATVEYVKTAVKSLRHGFGSAIVAAP 119

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAK-KVVMMLATEELRVALATTHLPLRDIADAITPA 179
             +  IN AGI F+G+       S     V +ML  ++LR+   T H  + +    + P 
Sbjct: 120 HSETAINSAGIVFSGYPSLLSASSGDHLPVFLMLIIDDLRITHVTLHCSVSEALQLLNPR 179

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +   I      L+ K GI  PRI V G+NPHAGEGG  G E+   + PV+ +L  +G+ 
Sbjct: 180 SVEAAIRATDATLK-KLGIERPRIGVFGINPHAGEGGLFGDEDARIVAPVVEKLAREGLA 238

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           + GP   D L   +   + D  +AM+HDQG   +K  G      + +G   + +SV HG 
Sbjct: 239 VVGPTGCDVLLADRA--SYDGFVAMFHDQGHGPIKLLGGRESSALCIGQEIVFSSVGHGA 296

Query: 300 ALELAGRGKADVGSFITALNL 320
           A ++AG+G AD+   + AL L
Sbjct: 297 AFDIAGQGIADIAPIVKALKL 317


>UniRef50_D0E8J8 Pyridoxal phosphate biosynthesis protein n=1 Tax=uncultured
           bacterium HF130_AEPn_1 RepID=D0E8J8_9BACT
          Length = 304

 Score =  130 bits (328), Expect = 5e-29,   Method: Compositional matrix adjust.
 Identities = 100/324 (30%), Positives = 151/324 (46%), Gaps = 36/324 (11%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATL-LTNRAAMLGLPLTLRPYSPNSP 64
           +++I  GE   IGP+               V   A L L +++++         Y P   
Sbjct: 7   KIIICSGEKDSIGPE---------------VTEKALLSLYDKSSLRLNEFKFEIYGPKEK 51

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
              +  G   L                E G+  ++ +  A +  L+G+  A++TGP+ K 
Sbjct: 52  FSKRALGLFEL---------------SEPGN-ALDFVREAVEQQLSGKAHAMVTGPIDKL 95

Query: 125 VINDAGIPFTGHTEFFEERS-QAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
                   F GHT +  +      + +M     ++ V+  T HLP +++ ++I    L +
Sbjct: 96  RWAKVLPGFLGHTGYLGQLCGHEDEPLMAFVGGKMIVSPLTIHLPFKEVPNSINIDFLEK 155

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ--GMKLN 241
            I +    L       + R+ VCGLNPHA + G MG EE   I P +  ++ +    ++ 
Sbjct: 156 KIFLCVKLLEDIKKSKKVRLAVCGLNPHASDKGLMGDEEEKFISPAIKLVQDKFPEAEIT 215

Query: 242 GPLPADTLFQPKYL-DNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
           GPLP DT F   ++ D  D V A+YHDQ L   K   F  GVNIT GLP IRTSVDHGTA
Sbjct: 216 GPLPGDTAFFKAFMEDEHDMVAAIYHDQALAPFKLLHFYDGVNITYGLPIIRTSVDHGTA 275

Query: 301 LELAGRGKADVGSFITALNLAIKM 324
            ELAG+G AD  S   A+  A+++
Sbjct: 276 YELAGKGAADHRSMENAILWAMRL 299


>UniRef50_B0SEJ8 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Leptospira
           biflexa serovar Patoc RepID=B0SEJ8_LEPBA
          Length = 314

 Score =  130 bits (327), Expect = 6e-29,   Method: Compositional matrix adjust.
 Identities = 95/241 (39%), Positives = 124/241 (51%), Gaps = 22/241 (9%)

Query: 87  GQLAVENGHYVVETLARACDGCLNGEFAA-LITGPVHKGVINDAGIP-FTGHTEFFEERS 144
           G+ +  +G    ++L  A D  L  E  A LIT P+ K  +  AGI  F GHTE   + +
Sbjct: 78  GKPSRASGKMAYDSLLSAID--LQKETGADLITLPLSKEWVVKAGINGFRGHTETLAD-A 134

Query: 145 QAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV------IAILHHDLRTKFGI 198
             +   MM++ E+L V   TTH+PL+D+   +T     E+         LHH        
Sbjct: 135 YKRPTFMMMSGEKLNVIPLTTHVPLKDVVRELTKFNWKELGRAITQSPYLHH-------- 186

Query: 199 AEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNA 258
             P+I   GLNPHAGEGG +G EE   +   ++ LR   + L GPL AD+ F P      
Sbjct: 187 --PKIGYLGLNPHAGEGGKIGKEETTLLKQGVSILRKAKLSLEGPLSADSAFLPD-AKPY 243

Query: 259 DAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITAL 318
           D  LA YHDQGL   K     +GVNITLGL F R S DHGTA  +AG+G AD    I+ L
Sbjct: 244 DLYLAGYHDQGLIPFKLLEGKKGVNITLGLDFTRVSPDHGTAFGIAGKGCADPTGLISCL 303

Query: 319 N 319
            
Sbjct: 304 E 304


>UniRef50_Q5HTM4 4-hydroxythreonine-4-phosphate dehydrogenase n=15 Tax=Campylobacter
           RepID=PDXA_CAMJR
          Length = 364

 Score =  124 bits (310), Expect = 6e-27,   Method: Compositional matrix adjust.
 Identities = 101/373 (27%), Positives = 166/373 (44%), Gaps = 67/373 (17%)

Query: 5   QRVVITPGEPAGIGPDLVV----QLAQREWPVELVVCADATLLTNRAAMLGLPLTL---- 56
           +++ I+ G+  GIG +++V    +L++   P   +     +LL   + +L L L      
Sbjct: 2   KKLAISIGDINGIGLEILVRSHEELSKICTPFYFI---HESLLDKASKLLNLKLFNAKIV 58

Query: 57  -----RPYSPNSPAQPQTAGTLTL-LPVALRA----PVTAGQLAVENGHYVVETLARACD 106
                + Y  N   +  +    +  LP+  +      + AG++  ++G Y   +   A  
Sbjct: 59  AFKDGKDYEFNFVKKENSLEIYSFYLPLDFKVDENFEIKAGEIDTKSGLYGFLSFKAASY 118

Query: 107 GCLNGEFAALITGPVHKGVINDAGIPFTGHTE----FFEERSQAKKVVMMLATEELRVAL 162
                   AL+T P+HK    DAG+ + GHT+    FF+     K  +MML  +EL V L
Sbjct: 119 FVYEKHAHALLTLPIHKKAWEDAGLKYKGHTDALRDFFK-----KNAIMMLGCKELFVGL 173

Query: 163 ATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEE 222
            + H+PL  ++  IT   L   +   + +   K      ++ + G NPHAG+ G +G EE
Sbjct: 174 FSEHIPLAKVSKKITFKNLSIFLKDFYKETHFK------KMGLLGFNPHAGDYGVIGGEE 227

Query: 223 ---IDTIIPVLN---------------------------ELRAQGMKLNGPLPADTLFQP 252
              ++  I  +N                             + +G+ L  PL ADT F  
Sbjct: 228 EKIMEKAIAFVNAFLHSKKDEKFFKKALKDENLQKELLLNFKGKGVYLPHPLVADTAFTK 287

Query: 253 KYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRG-KADV 311
             L N + ++AMYHD  L  LK   F + +N++L LP IR SVDHGTA + A +  K + 
Sbjct: 288 TGLKNCNRLVAMYHDLALAPLKALYFDKSINVSLNLPIIRVSVDHGTAFDKAYKNAKINT 347

Query: 312 GSFITALNLAIKM 324
            S+  A   AI +
Sbjct: 348 KSYFEAAKFAINL 360


>UniRef50_O85987 4-hydroxythreonine-4-phosphate dehydrogenase n=8 Tax=Proteobacteria
           RepID=PDXA_SPHAR
          Length = 330

 Score =  122 bits (307), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 78/226 (34%), Positives = 117/226 (51%), Gaps = 12/226 (5%)

Query: 94  GHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMML 153
           GH   + L        +G FAA I GP+  G +           +     +  +  +++L
Sbjct: 103 GHATAQWLDELDALARDGSFAATIMGPISTGSLK-----LAKKLDRVISPTPGESYLVLL 157

Query: 154 ATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAG 213
            T  LRVA  T H+ LR + D I+  L+   +  LH  +++ +GIA+PRI V GLNPHA 
Sbjct: 158 -TGPLRVAHLTDHMSLRQVIDVISADLVATAVGQLHEAMQS-WGIAQPRIAVAGLNPHA- 214

Query: 214 EGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVL 273
               MG E+   I P +   RA+G+ + GP+  D++F+       D VLAM+HDQG   +
Sbjct: 215 ----MGDEDRLEIAPGIEAARARGIDVEGPIAPDSVFRHCIEGRYDMVLAMFHDQGHIAV 270

Query: 274 KYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALN 319
           K  GF     I +G P++  SV HGTA ++ G GKAD    ++A+ 
Sbjct: 271 KTWGFSGNSVIIMGPPYLHMSVAHGTAYDIVGTGKADAAMMLSAMR 316


>UniRef50_A7T2T3 Predicted protein (Fragment) n=1 Tax=Nematostella vectensis
           RepID=A7T2T3_NEMVE
          Length = 371

 Score =  120 bits (300), Expect = 9e-26,   Method: Compositional matrix adjust.
 Identities = 55/165 (33%), Positives = 95/165 (57%), Gaps = 1/165 (0%)

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           L+T P++K  I      F GHT++ +   +   +++M+  ++ RV L T H+P+ +I+ +
Sbjct: 14  LVTAPINKYNIQSEDFKFPGHTDYLDSELEGDALMLMI-HDKFRVGLLTDHIPVNEISKS 72

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           ++  LL + +  +   L   FG+ +P++ + GLNPH+G+ G +G EE   I P + ++  
Sbjct: 73  LSEKLLMKKVGTIIKALEQDFGVVKPKVALLGLNPHSGDNGVIGDEEEKIIKPTVKKMFD 132

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGR 280
            GM + GP  +D+ F     +  DA+LAMYHDQGL   K   FG+
Sbjct: 133 SGMMVFGPYSSDSFFGSSQFEKYDAILAMYHDQGLIPFKTLSFGK 177


>UniRef50_Q4HSN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Campylobacter
           upsaliensis RM3195 RepID=Q4HSN6_CAMUP
          Length = 339

 Score =  117 bits (294), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 81/248 (32%), Positives = 119/248 (47%), Gaps = 17/248 (6%)

Query: 84  VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEER 143
           + AG++  ++G Y   +   AC         ALIT P+HK   N AGI F GHT+     
Sbjct: 95  IKAGEIDAQSGTYSFLSFEAACAFTHQKHATALITLPIHKKAWNLAGISFRGHTDALRN- 153

Query: 144 SQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRI 203
              K  +MML  ++L V L + H+ LRD++  I    L + +     D   + G    +I
Sbjct: 154 FYGKNAIMMLGCKKLFVGLFSEHIALRDVSSQIKLEPLTQFLI----DFYQESGF--KKI 207

Query: 204 LVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP------LPADTLFQPKYLDN 257
            V   NPHAG+    GT   +    +   +R   + +         L AD+ F P  L  
Sbjct: 208 GVLAFNPHAGD---FGTIGGEEESIIEEAIRCANLHIQKEIYLPQILVADSAFTPNSLKK 264

Query: 258 ADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGR-GKADVGSFIT 316
              ++AMYHD  L  LK   F + VN++L LP IRTSVDHGTA + A +  K    S+  
Sbjct: 265 CSRLVAMYHDLALAPLKALYFEKSVNVSLNLPIIRTSVDHGTAFDKAYQNAKISTKSYKE 324

Query: 317 ALNLAIKM 324
           A+ +A+ +
Sbjct: 325 AVKIALNL 332


>UniRef50_P94285 PdxA homolog (Fragment) n=1 Tax=Burkholderia cepacia
           RepID=P94285_BURCE
          Length = 258

 Score =  117 bits (293), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 78/229 (34%), Positives = 115/229 (50%), Gaps = 12/229 (5%)

Query: 87  GQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQA 146
           GQ +   G  VV  +A A     +G     I GP     I+   +   G     +E  Q 
Sbjct: 23  GQPSAAAGRAVVRWMALADRIAHDGLIGGWIMGP-----IDSTSLKLAGEVASIDEL-QP 76

Query: 147 KKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVC 206
           +   M   +  LRV   T H+PLRD+   +T   +  ++ +++  L+  +GI  PRI V 
Sbjct: 77  EHSFMFRMSGRLRVVPLTEHIPLRDVPATVTFDAVLNLVTLVNERLK-DWGIEAPRIGVA 135

Query: 207 GLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYH 266
           GLNPHA     M  EE   I P + + RAQG+ + GP+  D++F+       DAV++MYH
Sbjct: 136 GLNPHA-----MFEEEERIIGPAVEQARAQGIDVRGPVSPDSVFRHGLDGRYDAVVSMYH 190

Query: 267 DQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFI 315
           DQG   LK   F     + LG+P++R +V HGTA+ +AGR  A   S +
Sbjct: 191 DQGQIALKSAAFEGACTLYLGVPYVRATVPHGTAMGIAGRNLAQHHSMV 239


>UniRef50_C9PYW4 Pyridoxal phosphate biosynthetic protein PdxA n=1 Tax=Prevotella
           sp. oral taxon 472 str. F0295 RepID=C9PYW4_9BACT
          Length = 371

 Score =  115 bits (289), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 93/329 (28%), Positives = 144/329 (43%), Gaps = 10/329 (3%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPN 62
           R+ IT G+  GIG +L+ +        EL   +V     +       L L +        
Sbjct: 7   RIAITQGDANGIGMELIFKTFASPEMFELCTPIVYGSPKVAAYHKKALNLDVNFSIIQDG 66

Query: 63  SPAQPQTAGTLTLLPVALR-APVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           + A+P+    L LL +A     +  G    +      + + RA   C  G   A++  P+
Sbjct: 67  AEAKPER---LNLLAIADEDVKIEFGTPNEDAATLARKAIDRAVADCKAGVVGAIVNAPI 123

Query: 122 -HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
             K        P +      ++  +  +V+ M   E LR+   +  L ++D+A+ IT   
Sbjct: 124 SEKHFFTTQEQPVSLSQYIAKQLGETNEVLEMSLNECLRITTLSGELAIKDVANEITKER 183

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +   + +LHH LR  F I+ PR+ V  LNP   +G     EE + I P + +L A G   
Sbjct: 184 IESAVRLLHHSLRRDFMISIPRVAVLALNPTLEDGP--CKEEQEVIAPAVKQLIADGYMA 241

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP  AD+ F  +  D  DAVLAMYHDQ +   K      GV   +GL  + TS D    
Sbjct: 242 FGPYQADSFFGDREFDTFDAVLAMYHDQAMIPFKALSCEGGVRFIIGLSAVITSTDDEAL 301

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNTQ 329
              AG+G AD  +F  A+ LA+ +  N +
Sbjct: 302 DGKAGQGVADEIAFRHAIYLALDVSRNRK 330


>UniRef50_UPI00019786BC 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Helicobacter
           cinaedi CCUG 18818 RepID=UPI00019786BC
          Length = 312

 Score =  115 bits (289), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 80/246 (32%), Positives = 122/246 (49%), Gaps = 17/246 (6%)

Query: 84  VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEER 143
           +  G ++ E+G Y  ++  +A     +    AL+T P+HK    +AG+   GHT+   + 
Sbjct: 68  IQPGVVSKESGLYSYKSFLQAIKLTESRITQALVTLPIHKKAWQEAGVKSIGHTQVLSQY 127

Query: 144 SQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRI 203
             A  + MML  EE+ VAL T H+PLR ++ +I    +   +      +R    + EP  
Sbjct: 128 FGADSI-MMLGCEEMFVALYTDHIPLRKVSQSINQDSIKTFLLSFAGAVR----LNEP-C 181

Query: 204 LVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN-----GPLPADTLFQPKYLDNA 258
            V GLNPH G+GG MG E+   I   + E     M LN     G  P D+ F P      
Sbjct: 182 CVLGLNPHCGDGGLMGDED-KYITQAVCE---ANMVLNRELFFGAYPPDSAFSPLNRKKF 237

Query: 259 DAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRG--KADVGSFIT 316
              ++ YHD GL  LK   F + +N++L LP +RTSVDHG   ++A +   K    S++ 
Sbjct: 238 RYFVSQYHDVGLAPLKALYFEQSINVSLNLPILRTSVDHGVGFDVAYKKSVKIHTQSYMN 297

Query: 317 ALNLAI 322
           A+  A+
Sbjct: 298 AVKYAV 303


>UniRef50_D0J448 Terephthalate dihydrodiol dehydrogenase n=5 Tax=Comamonas
           RepID=D0J448_COMTE
          Length = 306

 Score =  112 bits (279), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 75/245 (30%), Positives = 121/245 (49%), Gaps = 8/245 (3%)

Query: 79  ALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTE 138
           +L  P   G++  + G   V++   A   C NGE  A+I  P H+  I+ AGI F+G+  
Sbjct: 61  SLAQPAQWGEITPQAGLSTVQSATAAIRACENGEVDAVIACPHHETAIHRAGIAFSGYPS 120

Query: 139 FFEE--RSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKF 196
                      +V +ML    LR+   T H  +R   + ++P L+   +        T  
Sbjct: 121 LLANVLGMNEDQVFLMLVGAGLRIVHVTLHESVRSALERLSPQLVVNAVQAAVQTC-TLL 179

Query: 197 GIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPAD-TLFQPKYL 255
           G+ +P++ V G+NPHA EG   G E+     P +  LR  G+ ++GP+ AD  L Q K+ 
Sbjct: 180 GVPKPQVAVFGINPHASEGQLFGLEDSQITAPAVETLRKCGLAVDGPMGADMVLAQRKH- 238

Query: 256 DNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFI 315
              D  +AM HDQG   +K         +++G   + +SV HG+A+++AGRG AD  + +
Sbjct: 239 ---DLYVAMLHDQGHIPIKLLAPNGASALSIGGRVVLSSVGHGSAMDIAGRGVADSTALL 295

Query: 316 TALNL 320
             + L
Sbjct: 296 RTIAL 300


>UniRef50_UPI0000D53588 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Psychroflexus
           torquis ATCC 700755 RepID=UPI0000D53588
          Length = 262

 Score =  103 bits (256), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 50/167 (29%), Positives = 91/167 (54%), Gaps = 1/167 (0%)

Query: 84  VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEER 143
           ++ G L  E G    E++  +      G+   L+T P++K  I+     F GHT++ + +
Sbjct: 88  ISFGVLNKEMGFAAYESIKNSVKDLRAGKIDVLVTPPINKEAIHSDEFQFMGHTDYIDGK 147

Query: 144 SQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRI 203
                  MM+ + +LRVAL T H+P+  + D+I+P L+   I +L+  L   F   +P+I
Sbjct: 148 IDGVST-MMMVSNDLRVALLTEHMPVSRVTDSISPELVERKINMLNDTLIRDFQKEQPKI 206

Query: 204 LVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLF 250
            +  ++PHAG+GG +   +   I+P +   + +G+ ++GP PAD+ F
Sbjct: 207 AILSIDPHAGDGGVISENDAQLIVPAVKISKDKGILIDGPFPADSFF 253


>UniRef50_Q47824 4-hydroxythreonine-4-phosphate dehydrogenase (Fragment) n=2
           Tax=Bacteria RepID=PDXA_ENTAG
          Length = 105

 Score = 99.4 bits (246), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 50/102 (49%), Positives = 66/102 (64%)

Query: 223 IDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGV 282
           I  + P +  ++AQGM + GP P DT+F     D  D V+AMYHDQG   LK  GF  GV
Sbjct: 1   IRILTPAVEAMKAQGMDVYGPCPPDTVFMQCNEDMYDIVVAMYHDQGHIPLKLLGFYDGV 60

Query: 283 NITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           NIT GLPF+RTS DHGTA  +A  GKA+  S   ++++A+K+
Sbjct: 61  NITAGLPFLRTSADHGTAFNIAWTGKANPESMAISIDMAMKI 102


>UniRef50_C6SCG8 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Neisseria
           meningitidis alpha153 RepID=C6SCG8_NEIME
          Length = 150

 Score = 85.1 bits (209), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 52/134 (38%), Positives = 68/134 (50%), Gaps = 6/134 (4%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQ 68
           +T GEPAGIGPD+ + LA    P    V  D  LL  RA  LG  + LR + P S     
Sbjct: 8   VTSGEPAGIGPDICLDLAFARLPCRCAVLGDKNLLRARAEALGKSVVLRDFDPESGGAAY 67

Query: 69  TAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVIND 128
             G L +L +     V AG+L   N  YV++ L  A  G  +G F  ++T P+HKG+IND
Sbjct: 68  --GELEVLHIPAAEAVEAGRLNPANAAYVLQLLDTALAGISDGIFDGIVTAPLHKGIIND 125

Query: 129 AGIPFTGHTEFFEE 142
           A       T FF+ 
Sbjct: 126 A----RASTGFFQR 135


>UniRef50_C3XJ32 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Helicobacter
           bilis ATCC 43879 RepID=C3XJ32_9HELI
          Length = 391

 Score = 79.7 bits (195), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 50/131 (38%), Positives = 73/131 (55%), Gaps = 8/131 (6%)

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEE--IDTIIPVLN-ELRAQGMKLN 241
           IA  +H L+ K    E +I V GLNPHAG+ G +G E+  I+  I ++N E+ A+     
Sbjct: 250 IAPHNHSLQPK---KELKIAVLGLNPHAGDNGVLGHEDMIINECIGIINKEIGAEVFI-- 304

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           G +  D+ F P   +     +AMYHD GL  LK   F R +N++L LP +RTS DHGT  
Sbjct: 305 GSIAPDSAFIPHNRERYSIFIAMYHDSGLAPLKALYFDRSINVSLNLPILRTSPDHGTCF 364

Query: 302 ELAGRGKADVG 312
           + A +   ++ 
Sbjct: 365 DKAYQSNNNIS 375



 Score = 69.3 bits (168), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 49/171 (28%), Positives = 86/171 (50%), Gaps = 13/171 (7%)

Query: 7   VVITPGEPAGIGPDLVVQ-LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           + ++ G+  GIG +L+++  A+     + + C D  +L   A  L L +    Y      
Sbjct: 1   MYVSVGDINGIGLELILRNHAEIAAYCKPIYCIDFEVLECAAKKLALQIPKDMY-----I 55

Query: 66  QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
            P     L +  +     + AGQ+  ++G Y  ++  +A +  +  E A+L+T P+HK  
Sbjct: 56  HP-----LNMQDIFDDEIIKAGQICAKSGLYSFKSFEKAVELSIEHE-ASLVTLPIHKYA 109

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
              AGI + GHT++   R Q K+ +MML  +E+ VAL T H+PL  ++  I
Sbjct: 110 WQLAGIEYAGHTQYLRHRFQ-KEAIMMLGCKEMFVALFTDHIPLSKVSSLI 159


>UniRef50_D0RPG9 Pyridoxal phosphate biosynthetic protein PdxA n=1 Tax=alpha
           proteobacterium HIMB114 RepID=D0RPG9_9RICK
          Length = 288

 Score = 73.9 bits (180), Expect = 8e-12,   Method: Compositional matrix adjust.
 Identities = 61/191 (31%), Positives = 94/191 (49%), Gaps = 18/191 (9%)

Query: 116 LITGPVHKG-VINDAGIPFTGHTEFFEERSQAKKVV-MMLATEELRVALATTHLPLRDIA 173
           LI  P++K   +N+    + G TEF+ ++   K    M+L      V   TTH+ ++D+ 
Sbjct: 85  LINMPLNKKKYLNNR---YFGFTEFYSKKIDNKNNENMLLFNNNFSVCPLTTHIQIKDVD 141

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRIL---VCGLNPHAGEGGHMGTEEIDTIIPVL 230
             IT    H  I I  +++   +     + +   V GLNPHAG+  +  +++   I  ++
Sbjct: 142 KKIT----HYKIKIALNNIINFYKKIIKKKINIIVLGLNPHAGKDFNNNSKD-KKIEKLI 196

Query: 231 NELRAQGMKLNGPLPADTLFQPKYLDNADAV-LAMYHDQGLPVLKYQGFGRGVNITLGLP 289
               A    + GP+ ADT F     D ++ V L MYHDQ L   K +    G+NIT+G  
Sbjct: 197 FSKFANKNNIKGPISADTAFT----DTSNKVFLGMYHDQVLIPFKMKNRFNGINITIGKK 252

Query: 290 FIRTSVDHGTA 300
           F R S DHGTA
Sbjct: 253 FYRLSPDHGTA 263


>UniRef50_UPI00016999D5 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Endoriftia
           persephone 'Hot96_1+Hot96_2' RepID=UPI00016999D5
          Length = 103

 Score = 67.0 bits (162), Expect = 8e-10,   Method: Compositional matrix adjust.
 Identities = 36/62 (58%), Positives = 43/62 (69%), Gaps = 1/62 (1%)

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIA 186
           N+AG PFTGHTE+  +  Q++  VMMLATE LRVALATTHLPL  ++  IT   L  VI 
Sbjct: 1   NEAGHPFTGHTEYLAQLCQSE-AVMMLATEGLRVALATTHLPLSQVSAQITRERLERVIR 59

Query: 187 IL 188
            L
Sbjct: 60  TL 61


>UniRef50_A7C3I0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Beggiatoa sp.
           PS RepID=A7C3I0_9GAMM
          Length = 222

 Score = 59.3 bits (142), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 49/177 (27%), Positives = 80/177 (45%), Gaps = 8/177 (4%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + IT G+PAG+GP++VV+        E+   +V  D +++ N  A+     T   +    
Sbjct: 6   IAITLGDPAGVGPEIVVKSFSNPKVYEVCRPLVIGDKSVIAN--ALTFCNKTANIHIIEK 63

Query: 64  PAQPQTA-GTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
           P Q +   GT+ L+ +     A +  G +    G    + + +A    + GE  AL T P
Sbjct: 64  PKQGKYQLGTIDLVNLQNIEIAKLQIGTIQAMCGQAAYDYIEKAVQLAMIGEVEALATTP 123

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           ++K  +  A I   GHTE  E  SQ    + M     +RV   + H+ LR   D +T
Sbjct: 124 INKESLRAANIEHIGHTEMLETLSQTNDPLTMFEVRGMRVFFLSRHVSLRQSCDLVT 180


>UniRef50_Q7X217 Putative 4-hydroxthreonine-4-phosphate dehydrogenase (Fragment) n=1
           Tax=Klebsiella pneumoniae RepID=Q7X217_KLEPN
          Length = 183

 Score = 51.2 bits (121), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 45/184 (24%), Positives = 80/184 (43%), Gaps = 28/184 (15%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELV---VCADATLLTNRAAMLGLPLTLRPYSPNS 63
           V IT G+PAGIGP++ V     +   +     +     +++    ++G    +     + 
Sbjct: 10  VAITIGDPAGIGPEITVATMMDKSVYDECKPFLIGSVPIISRAMKIMGCDFAI-----HK 64

Query: 64  PAQPQTA----GTLTLLPVAL---------RAPVTAGQLAVENGHYVVETLARACDGCLN 110
            A PQ A    GTL +L             +    AGQ++++   YV++++     G ++
Sbjct: 65  IAHPQEARFSWGTLDVLETGDYDCDSIEWGKVQKLAGQMSLD---YVMKSIELGKAGLID 121

Query: 111 GEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLR 170
                + T P+HK  I  AG    GHTE ++  +Q+   + M     LRV   + H+ L+
Sbjct: 122 ----VVSTAPIHKEAIKLAGCKLPGHTEIYQVETQSDYGLTMFHVHNLRVFFVSRHMALK 177

Query: 171 DIAD 174
              D
Sbjct: 178 AACD 181


>UniRef50_A6GMT1 Hemolysin activation/secretion protein-like protein n=1
           Tax=Limnobacter sp. MED105 RepID=A6GMT1_9BURK
          Length = 566

 Score = 44.3 bits (103), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 34/116 (29%), Positives = 53/116 (45%), Gaps = 12/116 (10%)

Query: 131 IPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD-----AITPALLHEVI 185
           +P+ G    FE+ S A +VV      EL   LA  +LP +DI +     A+ P +L  V 
Sbjct: 91  MPYVGEKRSFEDLSSAAQVVTAFLQRELGYYLAYAYLPAQDIKNGVVTIAVLPGVLESVE 150

Query: 186 AIL-HHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
            +    +LR    I E  +    L P    G  +  EE++ ++ +LN+LR   M  
Sbjct: 151 VVWPAEELRVNRDIVEAHL--KRLKP----GTVIRVEEVERVVFLLNDLRGIRMSF 200


>UniRef50_UPI000190527A 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Rhizobium etli
           Kim 5 RepID=UPI000190527A
          Length = 104

 Score = 40.8 bits (94), Expect = 0.075,   Method: Compositional matrix adjust.
 Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 2/99 (2%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQ 68
           IT G+P GIGP+++ ++     P + VV  D  ++     +L LPL ++P +      P 
Sbjct: 7   ITMGDPCGIGPEIIARVFADGLPEQAVVIGDTKVMERAVRVLNLPLQVQPIASVDNVLPD 66

Query: 69  TAGTLTLLPVA-LRAPVTAGQLAVENGHYVVETLARACD 106
           + G + +L V+ L   +  GQ+    G    + + RA D
Sbjct: 67  S-GLIAVLNVSDLPDDLPIGQVDARAGRASYDYVVRAID 104


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q3IFD2 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   427   e-118
UniRef50_A1U6F9 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   424   e-117
UniRef50_D2QDF7 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   423   e-117
UniRef50_Q11UL9 Pyridoxal phosphate biosynthesis protein n=3 Tax...   423   e-117
UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   419   e-116
UniRef50_C7R7U0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   417   e-115
UniRef50_B0KBL6 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   416   e-115
UniRef50_Q8CUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   416   e-115
UniRef50_A6TJU5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   412   e-114
UniRef50_Q87ST5 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   412   e-114
UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic prot...   407   e-112
UniRef50_C6VZ75 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   406   e-112
UniRef50_B8FEI1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   406   e-112
UniRef50_C5ELY2 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   406   e-112
UniRef50_D1UTB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   403   e-111
UniRef50_B2V9E6 4-hydroxythreonine-4-phosphate dehydrogenase n=5...   403   e-111
UniRef50_Q89ZK3 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   403   e-111
UniRef50_B1B883 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   401   e-110
UniRef50_Q2S3U3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   400   e-110
UniRef50_B2U6L2 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   400   e-110
UniRef50_C8QYR8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   400   e-110
UniRef50_C0QBU5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   399   e-110
UniRef50_A0JTQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=9...   399   e-110
UniRef50_A0LIN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   398   e-109
UniRef50_P58718 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   397   e-109
UniRef50_C6P2R8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   397   e-109
UniRef50_A6DS02 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   396   e-109
UniRef50_A3ERM0 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   396   e-109
UniRef50_Q1NMK1 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   392   e-108
UniRef50_B7UKV9 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   392   e-107
UniRef50_B2IDU5 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   391   e-107
UniRef50_A5CWR9 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   390   e-107
UniRef50_C9LG48 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   388   e-106
UniRef50_C1SJH6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   387   e-106
UniRef50_Q89NF3 4-hydroxythreonine-4-phosphate dehydrogenase 1 n...   387   e-106
UniRef50_B5YL57 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   387   e-106
UniRef50_C4X874 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   386   e-106
UniRef50_UPI0000E87C06 4-hydroxythreonine-4-phosphate dehydrogen...   386   e-106
UniRef50_A6GTC8 Pyridoxal phosphate biosynthetic protein PdxA n=...   385   e-105
UniRef50_C6E7W5 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   385   e-105
UniRef50_Q8D3I2 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   385   e-105
UniRef50_A6L8G2 4-hydroxythreonine-4-phosphate dehydrogenase n=7...   382   e-105
UniRef50_A7HYG3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   381   e-104
UniRef50_C7M3J3 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   381   e-104
UniRef50_Q1GI38 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   380   e-104
UniRef50_C6XHX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   379   e-104
UniRef50_C7PP38 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   379   e-104
UniRef50_C6X2C9 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   378   e-103
UniRef50_B4S6L0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   378   e-103
UniRef50_Q0FGB3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   377   e-103
UniRef50_D0LQB4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   377   e-103
UniRef50_Q215S3 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   376   e-103
UniRef50_B1L710 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   375   e-102
UniRef50_Q6AB12 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   375   e-102
UniRef50_Q02C14 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   375   e-102
UniRef50_A6H263 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   374   e-102
UniRef50_C6XKP9 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   374   e-102
UniRef50_A0LA33 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   373   e-102
UniRef50_Q7UMZ2 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   372   e-102
UniRef50_C0CYU8 Putative uncharacterized protein n=1 Tax=Clostri...   371   e-101
UniRef50_Q4JN67 Predicted 4-hydroxythreonine-4-phosphate dehydro...   371   e-101
UniRef50_B1IGV8 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   370   e-101
UniRef50_Q2N8X0 4-hydroxythreonine-4-phosphate dehydrogenase n=5...   368   e-100
UniRef50_D2R6V9 4-hydroxythreonine-4-phosphate dehydrogenase n=7...   368   e-100
UniRef50_Q475Q2 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   367   e-100
UniRef50_D0J9Z1 4-hydroxythreonin-phosphate dehydrogenase n=1 Ta...   365   2e-99
UniRef50_Q92X16 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   364   2e-99
UniRef50_Q0EWH4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   364   2e-99
UniRef50_C6C747 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   364   3e-99
UniRef50_A6C4H6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   364   3e-99
UniRef50_Q5NMX3 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   364   4e-99
UniRef50_P58711 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   362   1e-98
UniRef50_A5WDW5 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   360   3e-98
UniRef50_A0NP49 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   360   5e-98
UniRef50_A7IJ81 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   360   5e-98
UniRef50_Q8DHB4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   357   4e-97
UniRef50_Q2CJB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   354   2e-96
UniRef50_Q87AJ1 4-hydroxythreonine-4-phosphate dehydrogenase n=7...   353   5e-96
UniRef50_A8ME07 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   352   1e-95
UniRef50_Q30Z16 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   350   3e-95
UniRef50_UPI00019F1502 4-hydroxythreonine-4-phosphate dehydrogen...   350   3e-95
UniRef50_A8S524 Putative uncharacterized protein n=1 Tax=Clostri...   350   5e-95
UniRef50_D2TK32 Putative uncharacterized protein n=1 Tax=Citroba...   349   6e-95
UniRef50_D0RQA4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   348   2e-94
UniRef50_UPI0000D5482C 4-hydroxythreonine-4-phosphate dehydrogen...   344   2e-93
UniRef50_Q2KXH9 4-hydroxythreonine-4-phosphate dehydrogenase n=9...   344   3e-93
UniRef50_B8IXF1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   343   5e-93
UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   343   5e-93
UniRef50_Q92TP3 4-hydroxythreonine-4-phosphate dehydrogenase 3 n...   342   1e-92
UniRef50_Q9CKG8 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   342   1e-92
UniRef50_B4U950 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   341   3e-92
UniRef50_Q1DF36 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   340   4e-92
UniRef50_B8FR92 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   339   6e-92
UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   339   8e-92
UniRef50_B9XEU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   338   2e-91
UniRef50_C3JBU1 4-hydroxythreonine-4-phosphate dehydrogenase n=5...   338   2e-91
UniRef50_C5CPN5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   337   3e-91
UniRef50_Q390F1 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   336   7e-91
UniRef50_B1GZF5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   335   2e-90
UniRef50_B1ZQS3 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   332   2e-89
UniRef50_B2KET4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   330   5e-89
UniRef50_A6FY83 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   329   6e-89
UniRef50_Q30S58 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   329   7e-89
UniRef50_C5SNX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   329   1e-88
UniRef50_B4D0B0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   328   1e-88
UniRef50_A1VC56 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   328   1e-88
UniRef50_A1TTF8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   327   3e-88
UniRef50_Q7MAP7 PDXA HOMOLOG n=1 Tax=Wolinella succinogenes RepI...   327   5e-88
UniRef50_A7HIW4 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   326   6e-88
UniRef50_B5JFI3 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   324   2e-87
UniRef50_Q31DF6 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   322   9e-87
UniRef50_C0A8L4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   322   1e-86
UniRef50_Q17ZN0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   322   2e-86
UniRef50_C9PYW4 Pyridoxal phosphate biosynthetic protein PdxA n=...   318   1e-85
UniRef50_C3XMM1 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   318   2e-85
UniRef50_B6BUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   318   2e-85
UniRef50_B2UL26 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   318   2e-85
UniRef50_B3DY74 Pyridoxal phosphate biosynthesis protein n=1 Tax...   317   4e-85
UniRef50_C1A9L0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   317   5e-85
UniRef50_Q04UJ6 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   313   4e-84
UniRef50_A5GHP5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   310   5e-83
UniRef50_A9GKN1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   309   8e-83
UniRef50_A9LFJ9 Pyridoxal phosphate biosynthetic protein (Fragme...   309   1e-82
UniRef50_Q0C095 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   308   2e-82
UniRef50_Q4FMQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   303   6e-81
UniRef50_C5T2H3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   302   1e-80
UniRef50_D0E8J8 Pyridoxal phosphate biosynthesis protein n=1 Tax...   302   1e-80
UniRef50_UPI00019786BC 4-hydroxythreonine-4-phosphate dehydrogen...   298   2e-79
UniRef50_Q3V7R5 Pyridoxal phosphate biosynthetic protein n=1 Tax...   295   1e-78
UniRef50_Q0RWE6 Terephthalate dihydrodiol dehydrogenase n=2 Tax=...   290   5e-77
UniRef50_Q5HTM4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   290   6e-77
UniRef50_A1RD08 Pyridoxal phosphate biosynthetic protein n=2 Tax...   289   8e-77
UniRef50_O85987 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   277   3e-73
UniRef50_Q4HSN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   277   4e-73
UniRef50_B0SEJ8 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   270   5e-71
UniRef50_UPI0000D53337 pyridoxal phosphate biosynthesis protein ...   262   1e-68
UniRef50_D0J448 Terephthalate dihydrodiol dehydrogenase n=5 Tax=...   258   3e-67
UniRef50_P94285 PdxA homolog (Fragment) n=1 Tax=Burkholderia cep...   258   3e-67
UniRef50_UPI0000D53588 4-hydroxythreonine-4-phosphate dehydrogen...   232   1e-59
UniRef50_A7T2T3 Predicted protein (Fragment) n=1 Tax=Nematostell...   232   2e-59
UniRef50_A1FAW6 Pyridoxal phosphate biosynthetic protein PdxA (F...   229   1e-58
UniRef50_C3XJ32 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   221   4e-56
UniRef50_A7C3I0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   179   2e-43
UniRef50_Q47824 4-hydroxythreonine-4-phosphate dehydrogenase (Fr...   172   2e-41
UniRef50_D0RPG9 Pyridoxal phosphate biosynthetic protein PdxA n=...   162   2e-38
UniRef50_Q7X217 Putative 4-hydroxthreonine-4-phosphate dehydroge...   155   2e-36
UniRef50_C6SCG8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   116   1e-24
UniRef50_C2EXJ2 Putative uncharacterized protein (Fragment) n=4 ...   102   2e-20
UniRef50_UPI00016999D5 4-hydroxythreonine-4-phosphate dehydrogen...    87   7e-16

Sequences not found previously or not previously below threshold:

UniRef50_UPI000190527A 4-hydroxythreonine-4-phosphate dehydrogen...    98   5e-19
UniRef50_B6YQG1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...    79   2e-13
UniRef50_UPI000190303C 4-hydroxythreonine-4-phosphate dehydrogen...    72   2e-11
UniRef50_C2BLM4 Putative uncharacterized protein (Fragment) n=1 ...    69   3e-10
UniRef50_B5YG77 Phosphate acyltransferase n=2 Tax=Bacteria RepID...    49   3e-04
UniRef50_UPI00016A5E6C 4-hydroxythreonine-4-phosphate dehydrogen...    44   0.005
UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula...    44   0.009
UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas...    43   0.014
UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom...    43   0.017
UniRef50_B2JJC7 ATP-dependent helicase HrpA n=89 Tax=cellular or...    42   0.034
UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr...    41   0.066

>UniRef50_Q3IFD2 4-hydroxythreonine-4-phosphate dehydrogenase n=68
           Tax=Proteobacteria RepID=PDXA_PSEHT
          Length = 330

 Score =  427 bits (1099), Expect = e-118,   Method: Composition-based stats.
 Identities = 203/322 (63%), Positives = 244/322 (75%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           T R+ ITPGEPAGIGPDL+++LAQ+ W  +LV  ADA +L  RA  LGL + L  +  ++
Sbjct: 2   TLRIAITPGEPAGIGPDLLLKLAQQTWDAQLVAIADANMLKQRAKHLGLSIKLIEFDQHA 61

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A P  AG+L L  V +  PV  G L   NG YV++TL  A +  ++G FAA++TGPVHK
Sbjct: 62  AATPAPAGSLYLHQVDVAEPVELGVLNDANGQYVLDTLRIASEKNMDGTFAAVVTGPVHK 121

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
           G+IN AGI F+GHTE+F ++S    VVMMLAT+ LRVAL TTH+PL  ++ AIT   L +
Sbjct: 122 GIINKAGISFSGHTEYFAQQSNTADVVMMLATQGLRVALVTTHIPLAYVSRAITEDRLIK 181

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
           V +IL+HDL+TKFGI +PRILVCGLNPHAGE GH+G EEIDTIIP L  L  QGM L GP
Sbjct: 182 VASILNHDLQTKFGIEKPRILVCGLNPHAGEDGHLGREEIDTIIPTLEILNNQGMNLIGP 241

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           LPADTLFQ KYL+ ADAVLAMYHDQGLPVLKY+GFG  VNITLGLPFIRTSVDHGTAL+L
Sbjct: 242 LPADTLFQDKYLNEADAVLAMYHDQGLPVLKYKGFGNSVNITLGLPFIRTSVDHGTALDL 301

Query: 304 AGRGKADVGSFITALNLAIKMI 325
           AG+G ADVGSF  A+  AIK+ 
Sbjct: 302 AGKGTADVGSFELAIREAIKLA 323


>UniRef50_A1U6F9 4-hydroxythreonine-4-phosphate dehydrogenase n=125
           Tax=Proteobacteria RepID=PDXA_MARAV
          Length = 336

 Score =  424 bits (1091), Expect = e-117,   Method: Composition-based stats.
 Identities = 193/329 (58%), Positives = 235/329 (71%), Gaps = 1/329 (0%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M     + +T GEPAGIGP+L +QLA       LVV A   LL +RA+ LGL + L  + 
Sbjct: 1   MSTPVILALTAGEPAGIGPELCLQLATGSRDAGLVVIASGELLRDRASQLGLQIELHDWQ 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
           P   A    AG L++  V       AG+L   N  YV++TL  A  GCLNG+F  ++T P
Sbjct: 61  P-GVAAATRAGHLSVRHVEGCGSTVAGRLDKANSQYVLDTLTIAARGCLNGDFDGMVTAP 119

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           VHKGVIN+AGI F+GHTEF +E    ++VVMMLATEELRVAL TTHLPL+D++ AITP  
Sbjct: 120 VHKGVINEAGIVFSGHTEFLQELCGVERVVMMLATEELRVALVTTHLPLKDVSAAITPDR 179

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           L +V  IL+ DL+  FGI +PRILV GLNPHAGEGGH+G EEI+ I P L +LRA+G++L
Sbjct: 180 LTQVTRILNADLKAFFGIDQPRILVAGLNPHAGEGGHLGREEIEVIEPTLEQLRAEGIQL 239

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GPLPADTLF P +LDNADAVLAMYHDQGLPVLK+QGFGR VNITLGLP +RTSVDHGTA
Sbjct: 240 TGPLPADTLFTPHWLDNADAVLAMYHDQGLPVLKFQGFGRAVNITLGLPIVRTSVDHGTA 299

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNTQ 329
           L+LAG GKAD GS  TA+ +  +M    +
Sbjct: 300 LDLAGTGKADAGSLHTAIRVGEQMAQCRK 328


>UniRef50_D2QDF7 4-hydroxythreonine-4-phosphate dehydrogenase n=8 Tax=Bacteroidetes
           RepID=D2QDF7_9SPHI
          Length = 546

 Score =  423 bits (1089), Expect = e-117,   Method: Composition-based stats.
 Identities = 113/327 (34%), Positives = 168/327 (51%), Gaps = 5/327 (1%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREW---PVELVVCADATLLTNRAAMLGL-PLTLRPYSPN 62
           + I+ G+  GIGP+++++  Q          V+     +L     +L L    L      
Sbjct: 210 IGISLGDYNGIGPEVILKALQYNRLQKICTPVIYGSMRILNRYRNLLNLKDWNLNGAQTI 269

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
                +    +T  P      +  GQ+  + G   +  L RA D   +G+  AL+T P++
Sbjct: 270 GQISHKLTNVITCWP-DQNQDIQPGQVTADAGQAALACLQRAVDDLKDGKIDALVTAPIN 328

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K  I      F GHTE+  +    +  +M L ++ LRV + T H+PL  +   IT   + 
Sbjct: 329 KNNIQSDEFKFPGHTEYLAQEFGVQDNLMFLVSQTLRVGVVTGHVPLGRVRQNITRERIA 388

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
           + + ++ H L+  FGI +P+I V GLNPHAGE G +GTEE D I P++ + R +G  + G
Sbjct: 389 QKLTLMMHSLKQDFGIEKPKIAVLGLNPHAGEEGLLGTEENDIIKPLIADWRNKGQLVFG 448

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
           P PAD  F  +     DAVLAMYHDQGL   K   F  GVN T G+P +RTS DHGTA +
Sbjct: 449 PYPADGFFGTRAYTKFDAVLAMYHDQGLIPFKAIAFEEGVNFTAGMPAVRTSPDHGTAYD 508

Query: 303 LAGRGKADVGSFITALNLAIKMIVNTQ 329
           +AG+  AD  S + A+  AI +  N +
Sbjct: 509 IAGKDLADETSMLQAIYTAIDVARNRK 535


>UniRef50_Q11UL9 Pyridoxal phosphate biosynthesis protein n=3 Tax=Sphingobacteriales
           RepID=Q11UL9_CYTH3
          Length = 341

 Score =  423 bits (1088), Expect = e-117,   Method: Composition-based stats.
 Identities = 127/325 (39%), Positives = 177/325 (54%), Gaps = 3/325 (0%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + IT G+  G+GP+L+++       ++    V+ A+  LL     +LGL   L  +S  S
Sbjct: 12  IGITLGDFNGVGPELILKTFSDSRILKVCIPVIYANYKLLARYKKILGLYEELNFHSIRS 71

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
             + Q      L+       VT GQ   E+G     +L +A    L G   A++T P+ K
Sbjct: 72  IQEVQPKKINLLVCWEDDFEVTPGQPTNESGKAAFLSLEKAVSDALAGSIQAIVTAPIDK 131

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             I   G  F GHTE+  ER   K  +M++ +  ++VALAT H+ +  I   +T   L  
Sbjct: 132 KNIQQEGFTFAGHTEYLAERCGVKDNLMVMVSPTMKVALATAHVSVAQITANLTRERLLT 191

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            I +L++ L+  FGI +P+I V GLNPHAGE G MGTEE   I PV+ EL+ +G+ + GP
Sbjct: 192 KINLLYNSLKKDFGILKPKIAVLGLNPHAGENGMMGTEEQTLISPVIKELKDKGILIFGP 251

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
            PAD  F   +    D VLAMYHDQGL   K   F  GVN T GLPFIRTS DHGTA +L
Sbjct: 252 FPADGFFGQHHYTKFDGVLAMYHDQGLAPFKALCFDEGVNFTGGLPFIRTSPDHGTAYDL 311

Query: 304 AGRGKADVGSFITALNLAIKMIVNT 328
           AG+      SF +A+ LA  ++ N+
Sbjct: 312 AGKNLVAEESFRSAIYLACDLVKNS 336


>UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Lactobacillus
           paracasei subsp. paracasei 8700:2 RepID=C5F751_LACPA
          Length = 326

 Score =  419 bits (1078), Expect = e-116,   Method: Composition-based stats.
 Identities = 117/326 (35%), Positives = 180/326 (55%), Gaps = 4/326 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPV--ELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           T  + IT G+P+GIGP++ ++   +      E ++     ++T  A +L +   L     
Sbjct: 2   THFIGITIGDPSGIGPEISLKALMKNEQYLNESIIFGSKEIMTYYADLLKIKTPLNFIKD 61

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
               +        ++ + L   +  G+++  +G    + L  A D  +  +   ++T P+
Sbjct: 62  VDQFEAGKINIYNVMDIPL-DKIPIGEVSPISGDAAFQFLKVAIDLAMKKKIGPVVTAPL 120

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           +K  ++  G  F GHTE F E +  KK  MML +++L V   +TH+PLR   D +T A +
Sbjct: 121 NKDALHKGGHNFDGHTEIFAEFTGTKKYTMMLWSKKLAVVHVSTHVPLRKACDLVTKARV 180

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
            E I + +  ++ + GI++PRI V GLNPHAGE G  G EEI  I P + E ++QG+ + 
Sbjct: 181 EECIDLANSAIK-RLGISKPRIAVAGLNPHAGEDGLFGDEEIKEINPAVKEKQSQGIDVQ 239

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           G LP DT+F        D V+AMYHDQG   +K   F  GVN+TLGLP IRTSVDHGTA 
Sbjct: 240 GALPPDTVFLKASQGKFDIVVAMYHDQGHIPMKLLAFDEGVNVTLGLPIIRTSVDHGTAF 299

Query: 302 ELAGRGKADVGSFITALNLAIKMIVN 327
           ++AG+G A+  S + ++ LAIK   N
Sbjct: 300 DIAGKGIANESSMLASIALAIKFGHN 325


>UniRef50_C7R7U0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Kangiella
           koreensis DSM 16069 RepID=C7R7U0_KANKD
          Length = 332

 Score =  417 bits (1072), Expect = e-115,   Method: Composition-based stats.
 Identities = 186/330 (56%), Positives = 243/330 (73%), Gaps = 1/330 (0%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M++  R++IT GEPAGIGP+++V+LAQ     +L+ CA  TLL + A  L LPL L  ++
Sbjct: 1   MIQPARILITAGEPAGIGPEIIVKLAQEPCSDQLIACASPTLLKDTAQQLHLPLELSVFN 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            N  A     G L ++PV L +PV AG+L   N  YV++TL  A    +NG   A++TGP
Sbjct: 61  TNEEALAHRIGHLWIVPVELESPVIAGKLNQTNAAYVIKTLDTAHQLAINGAVNAILTGP 120

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           VHKG+IN +G+ FTGHTEFF ++S A KVVMMLATE LRVALATTHLPL++++ A+TP L
Sbjct: 121 VHKGIINQSGLAFTGHTEFFADKSNAHKVVMMLATEGLRVALATTHLPLKEVSGAVTPQL 180

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ-GMK 239
           L EVI IL H+L++KF +  P++LVCGLNPHAGE GH+G EE+DTIIP L ++R Q   +
Sbjct: 181 LQEVIEILIHELQSKFSLKRPKVLVCGLNPHAGEDGHLGREEVDTIIPTLEKMRTQFDAE 240

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           L GP+PADT FQPK+L   D VLAMYHDQGLP LKY+GFG+ +N+TLGLP+IRTSVDHGT
Sbjct: 241 LIGPIPADTAFQPKWLTQVDTVLAMYHDQGLPTLKYKGFGKAINLTLGLPYIRTSVDHGT 300

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNTQ 329
            L++AG+G AD+GS   AL    ++I N +
Sbjct: 301 GLDIAGQGLADIGSMHYALQFTQQLINNRK 330


>UniRef50_B0KBL6 4-hydroxythreonine-4-phosphate dehydrogenase n=3
           Tax=Thermoanaerobacter RepID=B0KBL6_THEP3
          Length = 331

 Score =  416 bits (1071), Expect = e-115,   Method: Composition-based stats.
 Identities = 122/323 (37%), Positives = 174/323 (53%), Gaps = 5/323 (1%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           V IT G+PAG+GP++ ++ A           ++     +L   A +L + + LR     +
Sbjct: 5   VAITMGDPAGVGPEISLKAAVSAEVSSFARPLILGSGLVLRYYANLLKISVPLRSIDSPA 64

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
             Q      +++  ++L A    G+++   G    E L       L GE +A+ T P++K
Sbjct: 65  EYQDGFVNYISVNNLSL-ADFEIGKVSPLCGRAAYEYLEAGIRMALRGEASAIATAPLNK 123

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             ++ AG+ F GHTE   + +  K   MML    LRV   +TH+ LR   D +    ++ 
Sbjct: 124 EALHRAGLEFAGHTEILAKLTGTKDYAMMLVAGNLRVMHVSTHVALRGACDMVKKERVY- 182

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            I  L        G+ +PRI V GLNPHAGEGG  G EEI  I P + + R QG+ + GP
Sbjct: 183 KIVTLAATAAASLGVRDPRIAVAGLNPHAGEGGLFGDEEIYEIAPAVEKAREQGLSVYGP 242

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           LP DT+F        D V+AMYHDQG   +K  GF RGVN+T+GLP IRTSVDHGTA ++
Sbjct: 243 LPPDTVFLKASRGEYDVVVAMYHDQGHIAVKMAGFERGVNVTVGLPIIRTSVDHGTAFDI 302

Query: 304 AGRGKADVGSFITALNLAIKMIV 326
           AGRG AD  S + A+ LA +M+ 
Sbjct: 303 AGRGIADERSMVEAVKLAAEMVK 325


>UniRef50_Q8CUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=45 Tax=Bacteria
           RepID=PDXA_OCEIH
          Length = 332

 Score =  416 bits (1070), Expect = e-115,   Method: Composition-based stats.
 Identities = 118/330 (35%), Positives = 182/330 (55%), Gaps = 6/330 (1%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLR 57
           M K   + IT G+ AG+GP+++++  +     E    +V  D  +L   A +L + ++  
Sbjct: 1   MSKKPIIGITMGDAAGVGPEIIIKSLRNRELYEQAHPIVIGDTKMLERAAKILDVDVSFD 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVA-LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
             + +        G +T + +  L   +  G+++  +G+   E L  A +    G+  A+
Sbjct: 61  KKTKDEELMDTEFGKITCIDLDILPEDLAYGEVSPVSGNAAFEYLRMAIELANEGKIQAI 120

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  +   G  + GHTE   E +  ++  MML++ +L+V   TTH+ L      I
Sbjct: 121 CTAPLNKEALQKGGHMYPGHTEILAELTNTEEFSMMLSSPKLKVIHVTTHVGLIQAIQMI 180

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRA 235
            P  +H+VI + H  L +  GI  P+I VCG+NPHAGE G  G  EE + IIP + +   
Sbjct: 181 KPERVHKVIQLAHETL-SNSGIKNPKIGVCGINPHAGENGLFGNGEEEEKIIPAIQQAVK 239

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G+ + GPLPADTLF      + D V+AMYHDQG   +K  G   GVNIT+GLP IRTSV
Sbjct: 240 EGINVEGPLPADTLFFRAQRGDFDIVVAMYHDQGHGPIKVLGLEAGVNITVGLPIIRTSV 299

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMI 325
           DHGTA ++AG+G  D  S + AL+ AI++ 
Sbjct: 300 DHGTAFDIAGKGIVDERSMLEALHQAIELA 329


>UniRef50_A6TJU5 4-hydroxythreonine-4-phosphate dehydrogenase n=14 Tax=Bacteria
           RepID=A6TJU5_ALKMQ
          Length = 346

 Score =  412 bits (1061), Expect = e-114,   Method: Composition-based stats.
 Identities = 122/344 (35%), Positives = 173/344 (50%), Gaps = 18/344 (5%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLR 57
           M K   + IT G+P GIGP++  +    +   E    +V   A +L    A+    L + 
Sbjct: 1   MNKLPILGITMGDPCGIGPEITAKALVHKNVYEVCRPIVVGSAKVLEAAIAICNKDLKVN 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRA--PVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
             S    A+    GT+ +          +  GQ++   G    E + +  D  + GE   
Sbjct: 61  VVSNVKEAKFAF-GTIDVFDQDHVDVWSLVRGQVSKIGGQGAYEAIEKVIDLAMKGEIDG 119

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
            ITGP++K  +N AG  + GHTE + + +  K   MMLA   LRV   +TH+ LR+  D 
Sbjct: 120 TITGPLNKEALNIAGYHYGGHTEIYAKLTGTKDYSMMLADGNLRVVHVSTHVSLREACDR 179

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
            T   +  VI +     ++  GI  PRI V GLNPH+GE G  G EEID IIP + + ++
Sbjct: 180 CTKERVGSVIKLAEEACKS-LGINRPRIAVAGLNPHSGENGLFGREEIDEIIPAIEKAKS 238

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFG-----------RGVNI 284
           +G+ + GP P DTLF        D V+AMYHDQG   +K  GF             GVNI
Sbjct: 239 EGLDVEGPEPPDTLFSKALGGQYDIVVAMYHDQGHIPVKVVGFQYNHELKRWNTVSGVNI 298

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           TLGLP IR+SVDHGTA   AG+G A+  S + A++   ++ V  
Sbjct: 299 TLGLPIIRSSVDHGTAFGQAGKGTANEESLVNAIDYGARLAVTR 342


>UniRef50_Q87ST5 4-hydroxythreonine-4-phosphate dehydrogenase n=34 Tax=Bacteria
           RepID=PDXA_VIBPA
          Length = 332

 Score =  412 bits (1060), Expect = e-114,   Method: Composition-based stats.
 Identities = 199/329 (60%), Positives = 244/329 (74%), Gaps = 1/329 (0%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
              +R+V+T GEPAGIGPDLV+ L++ +W  ++VVCAD  +L  RA MLG+ + L  Y+P
Sbjct: 4   NSIRRIVVTAGEPAGIGPDLVLALSKEDWAHQIVVCADKNMLLERAKMLGIDVQLFDYNP 63

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
               + Q AGTL +  V +     AGQL   NGHYV++TL RA  GC+N EF A++TGPV
Sbjct: 64  EEAPKAQKAGTLIVDHVEIAENAIAGQLNEANGHYVLKTLERAALGCMNDEFDAIVTGPV 123

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           HKGVIN AG+ F+GHTEFF E+S    VVMMLATE LRVAL TTH+PL  ++ A+T   L
Sbjct: 124 HKGVINRAGVAFSGHTEFFAEKSNTPLVVMMLATEGLRVALVTTHIPLAYVSKAVTEERL 183

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ-GMKL 240
            ++I ILH DL  KF IAEP I VCGLNPHAGE G +G EEI+TI P L +++ + G+KL
Sbjct: 184 EKIIDILHKDLVEKFAIAEPNIYVCGLNPHAGEDGCLGREEIETITPTLEKIQKEKGIKL 243

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GPLPADT+F  KYL++ADAVL MYHDQ LPVLKY+GFGR VNITLGLPFIRTSVDHGTA
Sbjct: 244 IGPLPADTIFNEKYLNDADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTA 303

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNTQ 329
           LELAG G+AD GSF TAL  AI+++   Q
Sbjct: 304 LELAGTGQADTGSFRTALTHAIELVEKKQ 332


>UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic protein pdxA n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q0V0_9BACT
          Length = 346

 Score =  407 bits (1047), Expect = e-112,   Method: Composition-based stats.
 Identities = 120/332 (36%), Positives = 176/332 (53%), Gaps = 6/332 (1%)

Query: 1   MVKTQR--VVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLT 55
           + K  +  + IT G+P GIGP+++V+       +     ++  +  +L + A  L +P  
Sbjct: 10  INKKPKLLIGITMGDPCGIGPEIIVRSLASSALKRAANYIIIGNQAVLDSTAQSLKIPFR 69

Query: 56  LRPYSPNSPAQ-PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFA 114
            R  S  +  +   T  +L          +       E G      + +  D  L G+  
Sbjct: 70  YRVVSLETDIERVSTPISLLSSEHFDLNLIKKRLPTAEGGELSFLWIKKGIDLALQGKIN 129

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
           AL+T P+ K  I+ AG  + GHTE   + S+ K+VVM++    LRVA  TTH+ L ++A 
Sbjct: 130 ALVTAPICKEAIHMAGYQYPGHTEILRDLSKVKRVVMLMIGGSLRVAFVTTHIALHEVAQ 189

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
           +IT   + E I I +  L+  F    PRI VCG+NPHAGE G  G EE + I+P + + +
Sbjct: 190 SITVKNVLETITICNTYLKKYFTPRNPRIAVCGVNPHAGEEGIFGNEEKNIIVPAVKKAK 249

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
             G++ NGP+ ADT+F        D V++MYHDQG   LK   F  GVNITLG+PFIRTS
Sbjct: 250 KLGVECNGPVSADTVFYKALKGQYDLVVSMYHDQGAIPLKLHAFETGVNITLGIPFIRTS 309

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIV 326
            DHGTA ++AG+G A+  S   A+  AI M  
Sbjct: 310 PDHGTAYDIAGKGIANPDSMKEAIMTAIMMAK 341


>UniRef50_C6VZ75 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Dyadobacter
           fermentans DSM 18053 RepID=C6VZ75_DYAFD
          Length = 368

 Score =  406 bits (1045), Expect = e-112,   Method: Composition-based stats.
 Identities = 114/329 (34%), Positives = 169/329 (51%), Gaps = 5/329 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGL-PLTLRPY 59
              + IT G+  GIGP+++++  +     +L   ++     +L     +L +   TL   
Sbjct: 8   KPVIGITIGDYNGIGPEVILKALEGNQLAKLCTPIIYGSLRVLNQYRNLLEMKDWTLHGI 67

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
                A  +    +T      +  +  G++  E G      L RA +    G   AL+TG
Sbjct: 68  QKAEQANHKLTNVITCWH-DHQTEIQPGKITAEAGQGSFAALKRAVEDLKEGRIQALVTG 126

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P++K  I +    F GHTEF  +  +    +M +   +LRV + T H+PL+++ + ITP 
Sbjct: 127 PINKDNIQNDDFKFPGHTEFLAQSFEKDDALMFMVAGDLRVGVLTGHMPLQNVREHITPE 186

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            L   I  +   L+  FGI +P++ V GLNPHAGE G +G+EEI+ I PV+ + + +G  
Sbjct: 187 KLSAKIEQILQSLKGDFGIKKPKLAVLGLNPHAGENGLLGSEEIEIIQPVIKQFKEKGHL 246

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           + GP PAD  F        DAVLAMYHDQGL   K   F  GVN T GLP +RTS DHGT
Sbjct: 247 VVGPFPADGFFAAGTYRQYDAVLAMYHDQGLIPFKTLAFNEGVNFTAGLPAVRTSPDHGT 306

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           A  +AG+  A+ GS + AL LA  +    
Sbjct: 307 AYNIAGKNVAEPGSLLQALYLACDVSRFR 335


>UniRef50_B8FEI1 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Desulfatibacillum alkenivorans AK-01
           RepID=PDXA_DESAA
          Length = 333

 Score =  406 bits (1044), Expect = e-112,   Method: Composition-based stats.
 Identities = 125/334 (37%), Positives = 178/334 (53%), Gaps = 6/334 (1%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLR 57
           M     + IT G+P G+GP+++V+  + +        +V  D  ++    +++   L  R
Sbjct: 1   MKSLPIIGITMGDPVGVGPEIIVKTLKNKDIYKICRPLVIGDLKVMEQAESLIRSGLDFR 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
           P      A  +  G + +LPV+   P  +       + G  +V+ +  A D   +    A
Sbjct: 61  PAGSPEDAAYEY-GRVDILPVSDLDPARLAPKTPCAKTGEAMVKYITTAVDYARDNRIQA 119

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           + TGP+ K  ++ AG  F GHTE   +R+   K VMMLA ++LRV L T H+ + +I   
Sbjct: 120 VTTGPIQKAAVHAAGYTFAGHTELLAQRTGTSKYVMMLAGDKLRVVLVTIHMAVSEIPAH 179

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           +T     E + +    L+ +FGI +P++ V  LNPHAGE G  GTEE D IIP +   + 
Sbjct: 180 VTREKFIETVEVTGQALKERFGIPQPKMAVAALNPHAGEEGAFGTEERDVIIPAMEHFKG 239

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
             + L+GP PADTLF        DAV+ MYHDQGL   K   F  GVN TLGLP IRTSV
Sbjct: 240 SDIALDGPWPADTLFYHAQQGKWDAVVCMYHDQGLIPFKMIHFHDGVNTTLGLPIIRTSV 299

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           DHGTA +LAG GKAD GS   A+ +A     N +
Sbjct: 300 DHGTAYDLAGTGKADHGSMEAAIRMAALQASNLK 333


>UniRef50_C5ELY2 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Bacteria
           RepID=C5ELY2_9FIRM
          Length = 358

 Score =  406 bits (1044), Expect = e-112,   Method: Composition-based stats.
 Identities = 122/346 (35%), Positives = 180/346 (52%), Gaps = 19/346 (5%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREW---PVELVVCADATLLTNRAAMLGL-PLTL 56
           M +   + IT G+PA IGP++ V+             +V  DA ++     ++G   + +
Sbjct: 1   MDERLIIGITMGDPASIGPEITVKALANNEIYDKCRPLVIGDAGVMEAAVKIVGKEDVRI 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPVAL--RAPVTAGQLAVENGHYVVETLARACDGCLNGEFA 114
            P      A  Q AGT+ +  + L     +  G+++V  G      + +     + GE  
Sbjct: 61  HPVHSVEEALFQ-AGTIDVYDMDLVDMDKLERGKVSVMAGEAAFRYVEKVIQMAMAGEVD 119

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
             +T   +K  IN AG  ++GHTE + + +  KK  MMLA E +RV   +TH+ LR+  D
Sbjct: 120 GTVTNAFNKEAINMAGHHYSGHTEVYADMTGTKKYTMMLAHENIRVVHVSTHVSLREACD 179

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +    + EVI I +   R   G+ +PRI V GLNPH+GE G  G EEID IIP +   +
Sbjct: 180 RVKKDRVLEVIRIAYQACR-DLGLEQPRIGVAGLNPHSGENGLFGREEIDEIIPAIEAAK 238

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGF-----------GRGVN 283
           A+G++  GP+P DT+F        D V+AMYHDQG   LK  GF             GVN
Sbjct: 239 AEGIQAEGPVPPDTIFSKARGGWYDMVVAMYHDQGHIPLKVIGFVYNQEQQKWDAVAGVN 298

Query: 284 ITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           ITLGLP +R SVDHGTA + AG+G A+  S I A++  I++  + +
Sbjct: 299 ITLGLPIVRASVDHGTAFDQAGQGIANELSLINAIDYGIRLSKSNK 344


>UniRef50_D1UTB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Burkholderia
           sp. CCGE1001 RepID=D1UTB0_9BURK
          Length = 784

 Score =  403 bits (1037), Expect = e-111,   Method: Composition-based stats.
 Identities = 125/333 (37%), Positives = 178/333 (53%), Gaps = 7/333 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLR 57
           M     + IT G+ AG+GP+++++             +V  D+  L +     G+ L++R
Sbjct: 449 MTYRPVIGITMGDAAGVGPEIIMKSLAHASVYDGCRPLVIGDSKRLVDAGQRTGVTLSVR 508

Query: 58  PYSPNSPAQPQTAGTLTLLPVAL-RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
           P +  + A+ Q  G +  + + L  A +  G+L+   G    + +AR  +    GE  A+
Sbjct: 509 PIASPAEARFQY-GEVDCIDLGLIPADLPYGKLSAVAGDAAYQYIARTVELTSAGELDAI 567

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  ++  G  F GHTE     +   +V MML   +LRV   TTH+ L D    I
Sbjct: 568 CTAPLNKEALHAGGHIFPGHTEMLAHLTGIPEVSMMLVAPKLRVIHVTTHIGLLDAIRRI 627

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRA 235
            P L+   I   H  L  + GI EPRI VCG+NPHAGE G  G  EE + I+P +  LR 
Sbjct: 628 EPGLVQRTIERAHETL-VRAGIDEPRIGVCGINPHAGENGLFGYGEEEEKIVPAVAVLRE 686

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G  + GPLPADTLF      + D V+AMYHDQG   +K  G   GVN+T+GLP IRTSV
Sbjct: 687 RGWDVEGPLPADTLFFRAGRGDFDVVVAMYHDQGHGPVKVMGLEAGVNVTVGLPVIRTSV 746

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           DHGTA ++AG+G AD  S + AL  A  +    
Sbjct: 747 DHGTAFDIAGKGIADERSMLEALKQAEDLATRR 779


>UniRef50_B2V9E6 4-hydroxythreonine-4-phosphate dehydrogenase n=5 Tax=Aquificales
           RepID=PDXA_SULSY
          Length = 322

 Score =  403 bits (1037), Expect = e-111,   Method: Composition-based stats.
 Identities = 114/326 (34%), Positives = 179/326 (54%), Gaps = 8/326 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           ++ IT G+P+GI  +++++   +  +  +  V+      L     + G+ L ++     +
Sbjct: 3   KLAITLGDPSGINSEILLKALNKLPKRNISYVIYGSKKALEKAKKLTGVDLNIKEIKSIN 62

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
                    + L  +     V  G  + E G   V  L  A    L  +  ALIT P+ K
Sbjct: 63  DVVKSGIYLINLYDL----DVEFGSSSKETGKASVVYLENAVKDVLEKKADALITLPISK 118

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             I ++G P+ GHT++  E S AK+  M+L  ++L+VAL TTH+PL+D+   IT   +  
Sbjct: 119 QWIMESGFPYAGHTDYLAEVSGAKEYAMVLMCKKLKVALITTHIPLKDVPSQITKEKIIS 178

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            + +++ + + KFGI++P+I + GLNPHA + G++G EE + I+P +  LR  G+++  P
Sbjct: 179 KVRLINREFKEKFGISKPKIAILGLNPHASDNGNIGNEEQNIILPAVKTLREDGIEITDP 238

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           L  DT F      + D  +AMYHDQGL  LK   F + VNITLGLPFIRTS DHGT  ++
Sbjct: 239 LSPDTAFNR--YKDFDIYVAMYHDQGLIPLKLLCFRKAVNITLGLPFIRTSPDHGTGYDI 296

Query: 304 AGRGKADVGSFITALNLAIKMIVNTQ 329
           AG+  AD  S I A+ LAI +    +
Sbjct: 297 AGKNIADPSSTIEAVELAILLKRVRK 322


>UniRef50_Q89ZK3 4-hydroxythreonine-4-phosphate dehydrogenase n=33 Tax=Bacteroidales
           RepID=PDXA_BACTN
          Length = 364

 Score =  403 bits (1036), Expect = e-111,   Method: Composition-based stats.
 Identities = 115/334 (34%), Positives = 165/334 (49%), Gaps = 7/334 (2%)

Query: 1   MVKTQ-RVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTL 56
           M + + R+ IT G+  G+G +++++       +EL   ++     +       L +    
Sbjct: 1   MEENKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPKVAAYHRKALDVQANF 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
              +  S A       +          V   +   E G   +  L RA +    G    +
Sbjct: 61  SIVNTASEAGYNRLSVVNC--TDDEVKVEFSKPDPEAGKAALGALERAIEEYREGLIDVI 118

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADA 175
           +T P++K  I      F GHTE+ EER     K +M+L   + RVAL TTH+P+R+IA  
Sbjct: 119 VTAPINKHTIQSEEFSFPGHTEYIEERLGNGNKSLMILMKNDFRVALVTTHIPVREIATT 178

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           IT  L+ E + I H  L+  FGI  PRI V  LNPHAG+GG +G EE + IIP + E+  
Sbjct: 179 ITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLGMEEQEIIIPAMKEMEE 238

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G+   GP  AD         + D +LAMYHDQGL   K      GVN T GLP +RTS 
Sbjct: 239 KGIICYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAMEDGVNYTAGLPVVRTSP 298

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
            HGTA ++AG+G A   SF  A+ +AI +  N Q
Sbjct: 299 AHGTAYDIAGKGLASEDSFRQAIYVAIDVFRNRQ 332


>UniRef50_B1B883 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Bacteria
           RepID=B1B883_CLOBO
          Length = 323

 Score =  401 bits (1032), Expect = e-110,   Method: Composition-based stats.
 Identities = 102/318 (32%), Positives = 171/318 (53%), Gaps = 4/318 (1%)

Query: 7   VVITPGEPAGIGPDLVVQLAQ--REWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           + IT G+PAGIG +++++      E+  + ++     ++     +L +   +      + 
Sbjct: 4   IGITMGDPAGIGAEIILKALDKYDEYRKKSIIFGSKDVMEFYRDILNVNAHINIIEDINE 63

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
                   +  + +++   +  GQ++   G    + +  +    LN +  A++T P++K 
Sbjct: 64  FNDSCINLVNCVDISM-DDIKIGQVSGRCGDAAYKYVEESIKWALNKKIKAVVTTPLNKK 122

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
            ++     F GHTE F + +  KK  M+L +++L+V   +TH+ L +    +    + +V
Sbjct: 123 ALHLGNHNFDGHTEIFAKLTGTKKYAMLLWSDDLKVIHVSTHISLFNACKNVKKERIFDV 182

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL 244
           I + +   + K G+  PRI V GLNPHAGE G  GTEEI+ I P + E R +G+ ++GP+
Sbjct: 183 INLANDTFK-KMGVKNPRIAVAGLNPHAGEDGIFGTEEINEIGPAVEEARKRGINVHGPI 241

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELA 304
           P D +F   Y    D V+AMYHDQG   +K   F  GVNIT+GLP IRTSVDHGTA ++A
Sbjct: 242 PPDIVFLKAYNKEYDIVVAMYHDQGHIPMKLLEFDSGVNITVGLPIIRTSVDHGTAFDIA 301

Query: 305 GRGKADVGSFITALNLAI 322
           G   A+  S I A+ ++ 
Sbjct: 302 GNLVANDKSLIQAIKVSC 319


>UniRef50_Q2S3U3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Rhodothermaceae RepID=Q2S3U3_SALRD
          Length = 402

 Score =  400 bits (1029), Expect = e-110,   Method: Composition-based stats.
 Identities = 115/329 (34%), Positives = 166/329 (50%), Gaps = 4/329 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGL-PLTLRPY 59
             R+ IT G+P GIGP++V++       +     V+   A +L   A +LG   L +   
Sbjct: 66  PTRLAITLGDPNGIGPEVVLKSLHDPSLMPSMTPVLIGSAHVLRVHADVLGFSDLDIHIV 125

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
                  P     +  +      PV  G +  E G   +  + RA + C  G   A++T 
Sbjct: 126 DEVPEEVPHGDVAVLDVAEDPEPPVMFGSITAEGGRLAMRAVERAVEACQAGTVDAMVTA 185

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P+ K  +   G    GHTEF  +++ + +  MM+    LRV L T+H  L ++  A+T  
Sbjct: 186 PISKDAVRQGGYDVPGHTEFLADKTNSPQPTMMMVAGGLRVGLVTSHTALSEVPSAVTEE 245

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            + E + ++   LR  F I +P+I V GLNPHAGE G  G EE + I P L   R +G +
Sbjct: 246 AILEKLRVIDASLRDDFAIEQPKIAVFGLNPHAGEAGAFGQEEEEVIAPALRAARQEGFR 305

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           + GP+ AD  F  +   + DA LAMYHDQGL   K   F  GVN T GLP +RTS DHGT
Sbjct: 306 VEGPMAADGFFGTQLDADHDAALAMYHDQGLVPFKALAFDHGVNYTAGLPIVRTSPDHGT 365

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           A  +AG+G A  GS   A+ LA+ +  + 
Sbjct: 366 AYGIAGKGMALPGSMRNAMELAVAIARHR 394


>UniRef50_B2U6L2 4-hydroxythreonine-4-phosphate dehydrogenase n=8 Tax=Proteobacteria
           RepID=B2U6L2_RALPJ
          Length = 770

 Score =  400 bits (1028), Expect = e-110,   Method: Composition-based stats.
 Identities = 124/330 (37%), Positives = 173/330 (52%), Gaps = 7/330 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLR 57
           M     + IT G+ AG+GP+++++        E    +V  D   L + A   G  L +R
Sbjct: 431 MTYRPVIGITMGDAAGVGPEIIMKALTHRAVYEQCRPLVIGDTARLRDAAQRTGAALEVR 490

Query: 58  PYSPNSPAQPQTAGTLTLLPVAL-RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
                + A  +  G +  + + L  A +  G+L+   G    + +AR  +    GE  A+
Sbjct: 491 SIERPADAAFRY-GVVDCIDLGLIPADLPYGKLSPIAGDAAYQYIARTVELTSAGELDAI 549

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  ++  G  F GHTE     +   +V MML    LRV   TTH+ L D    I
Sbjct: 550 CTAPLNKEALHAGGHIFPGHTEMLAHLTGIDEVSMMLVAPNLRVIHVTTHIGLLDAIRRI 609

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRA 235
            P L+   I   H  L  + GI  PRI VCG+NPHAGE G  G  EE   IIP +  L+A
Sbjct: 610 EPGLVQRTIERAHATL-VRAGIENPRIGVCGINPHAGENGLFGHGEEEQKIIPAVQVLQA 668

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G ++ GPLPADTLF      + D V+AMYHDQG   +K  G   GVN+T+GLP IRTSV
Sbjct: 669 RGWRVEGPLPADTLFFRAGRGDFDVVVAMYHDQGHGPVKVMGLEAGVNVTVGLPVIRTSV 728

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMI 325
           DHGTA ++AG+G AD  S + A   A ++ 
Sbjct: 729 DHGTAFDIAGKGIADERSMLEAFRQACELA 758


>UniRef50_C8QYR8 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QYR8_9DELT
          Length = 342

 Score =  400 bits (1028), Expect = e-110,   Method: Composition-based stats.
 Identities = 124/337 (36%), Positives = 177/337 (52%), Gaps = 22/337 (6%)

Query: 11  PGEPAGIGPDLVVQLAQREWPVE---------------LVVCADATLLTNRAAMLGLPLT 55
            G PAG+GP+++++L                        VV  D  +L   A  LG+ + 
Sbjct: 1   MGCPAGVGPEIILRLHLEREQARQAGTTETGRQEPAAAAVVLGDLGVLAQCARQLGVKVE 60

Query: 56  LRPYSPNSPAQPQTAGTLTLLPVALRAPVT-AGQLAVENGHYVVETLARACDGCLNGEFA 114
           L P+    P QP  +G L +LPV   AP+   G+  V +G  + E + +A     +GE A
Sbjct: 61  LNPWQ---PGQPLGSGALNVLPVTSLAPLPSPGRPTVASGRAMGEYIEQAVALAQSGELA 117

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
           A++T P+ K ++N  G  + GHTE         +  MM+A   LRV+L + H PL  + +
Sbjct: 118 AMVTCPIGKDMLNAGGYHYPGHTEMLATLCNCSEYAMMMAGARLRVSLVSIHRPLSRVPE 177

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
           A+T   +  +I +    L+  F +  PR+ V  LNPHAGEGG  G EE   I P + +  
Sbjct: 178 AVTQEAVVRLIRLTARSLQHDFAVLRPRLAVAALNPHAGEGGMFGDEEKRVIEPAVAQAA 237

Query: 235 A---QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFI 291
           A   + + ++GP P DT+F      + DAV+AMYHDQGL   K   F  GVN+T+GLP I
Sbjct: 238 ALLGREVSISGPRPPDTVFYQASQGDFDAVVAMYHDQGLIPFKLLHFKDGVNVTIGLPII 297

Query: 292 RTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           RTSVDHGTA ++AGRG AD  S   A  LA ++  N 
Sbjct: 298 RTSVDHGTAYDIAGRGVADHDSLRAAFWLAAEIAANR 334


>UniRef50_C0QBU5 4-hydroxythreonine-4-phosphate dehydrogenase n=10
           Tax=Deltaproteobacteria RepID=PDXA_DESAH
          Length = 340

 Score =  399 bits (1027), Expect = e-110,   Method: Composition-based stats.
 Identities = 119/328 (36%), Positives = 179/328 (54%), Gaps = 7/328 (2%)

Query: 1   MVKTQR-VVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTL 56
           M   +  + IT G+P GIGP+++V      +       +V  D  ++     +    + +
Sbjct: 1   MTDNRPVIGITMGDPVGIGPEIIVSALDDPFVYTVCRPLVLGDEGVMERAIDLKSARMDV 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFA 114
                 +  +    GT+ ++P++    A + AG      G  +++ +    D  ++G+  
Sbjct: 61  HTTDTPAGGK-YCHGTMDIVPLSRLDAATLLAGHPTPGTGKAMIDYITTGVDLAMDGKIQ 119

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
           A+ T P+ K  +  AG  F GHTE   +R+   +V MM+A + LRV L T H+PL +++ 
Sbjct: 120 AIATCPITKTAMKLAGSKFHGHTELIADRTHTPRVAMMMAGDRLRVVLVTIHIPLCEVSA 179

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +  A +   I++    L+TKFGI EPRI V GLNPH GE G  G+EE++ I P + + R
Sbjct: 180 RLNQAEILATISLTSETLKTKFGIPEPRIAVAGLNPHGGEDGMFGSEELEIIAPAVEQAR 239

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           ++G+ ++GP P DTLF        DAV+ MYHDQGL   K   F  GVN TLGLP IRTS
Sbjct: 240 SKGITVSGPFPPDTLFFNAANHKFDAVVCMYHDQGLIPFKMIHFSDGVNTTLGLPIIRTS 299

Query: 295 VDHGTALELAGRGKADVGSFITALNLAI 322
           VDHGTA ++A RG AD  S I A+ +A 
Sbjct: 300 VDHGTAYDIAWRGTADPSSLIAAIKMAA 327


>UniRef50_A0JTQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=9 Tax=Bacteria
           RepID=A0JTQ9_ARTS2
          Length = 792

 Score =  399 bits (1027), Expect = e-110,   Method: Composition-based stats.
 Identities = 126/324 (38%), Positives = 175/324 (54%), Gaps = 7/324 (2%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           V +T G+ AG+GP++VV              VV  DA  L   A +LG+   +       
Sbjct: 464 VAVTMGDGAGVGPEVVVAAVLDPQSNKECRPVVIGDALRLRQAADVLGIEADIHTIEKVE 523

Query: 64  PAQPQTAGTLTLLPVAL-RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
            A   T G + ++ +AL    +  GQL+   GH   E +  A +  + G   A+ T P++
Sbjct: 524 DAVF-TPGRVNVIDLALLPEDLPWGQLSPVAGHAAYEYIRVASELAMAGTVQAICTAPLN 582

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K  ++ AG  F GHTE   + +  ++V MML+T ++RV   TTH+ L D    I P L+ 
Sbjct: 583 KEALHAAGHIFPGHTELLAQLTGTEEVSMMLSTPKIRVIHVTTHIGLMDAIRKINPDLVE 642

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRAQGMKLN 241
             I   H  L  + GI  P+I VC +NPHAGE G  G  EE + I P +   +A G+ + 
Sbjct: 643 RTIRRGHEAL-VRAGIPNPKIGVCAINPHAGENGLFGQGEEAEKIEPGVKAAQAAGIDVT 701

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GPLPADTLF      + D V+AMYHDQG   +K  G   GVNIT+GLP IRTSVDHGTA 
Sbjct: 702 GPLPADTLFFLAGRGDYDLVVAMYHDQGHGPVKVLGIEAGVNITVGLPVIRTSVDHGTAF 761

Query: 302 ELAGRGKADVGSFITALNLAIKMI 325
           ++AG+  AD  S + AL+ A +M 
Sbjct: 762 DIAGKAIADPRSMVEALHQAAEMA 785


>UniRef50_A0LIN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Syntrophobacter fumaroxidans MPOB RepID=PDXA_SYNFM
          Length = 345

 Score =  398 bits (1024), Expect = e-109,   Method: Composition-based stats.
 Identities = 129/333 (38%), Positives = 176/333 (52%), Gaps = 7/333 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPY 59
              R+ +T G+P G+GPD++ Q        E    +V  D + L    A+ G    +   
Sbjct: 4   SKPRIALTMGDPCGVGPDVIAQALASPTLFECCTPIVVGDPSALQRSMALSGASKKVLVL 63

Query: 60  SPNS--PAQPQTAGTLTLLPVALRA-PVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
              +  P  P +     + PV L    +  G+        VV  +  A    L G+   +
Sbjct: 64  REPAELPDDPGSDRIPLIAPVELSGRDIEHGRPTAATCGAVVRYIESAVAFALAGQVRGV 123

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            TGP++K  +++ G  F GHTEF +  + +++VVMMLA   LRV+LAT H  L D+   +
Sbjct: 124 CTGPINKARMHEHGFDFPGHTEFLQALTGSRRVVMMLAGPRLRVSLATIHEALADVPALL 183

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
              +L EVI I    L   FG+  PR+ V GLNPHAGE G  G EEI+ + P +  LR  
Sbjct: 184 NVEMLREVIRITAEALIRDFGLQAPRLAVAGLNPHAGEEGRFGREEIEILRPAIESLRPP 243

Query: 237 G-MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           G   + GP PADTLFQ  +    DAV+AMYHDQGL  +K   F   VN++LGLP +RTSV
Sbjct: 244 GRCTVTGPYPADTLFQRAHAGEFDAVVAMYHDQGLVPIKLVHFYDAVNVSLGLPIVRTSV 303

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           DHGTA +LAG G+A  GS   A+ LA  M  N 
Sbjct: 304 DHGTAYDLAGTGRAHPGSLTAAVQLAALMAHNR 336


>UniRef50_P58718 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=29 Tax=Bacteria
           RepID=PDXA2_SALTY
          Length = 327

 Score =  397 bits (1022), Expect = e-109,   Method: Composition-based stats.
 Identities = 121/329 (36%), Positives = 181/329 (55%), Gaps = 7/329 (2%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREW--PVELVVCADATLLTN-RAAMLGLPLTLRP 58
           ++T+ V IT G+PAGIGP+++V+    +      LVV      L   +A  +   + LR 
Sbjct: 1   METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKRLQAKGITPNVELRA 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
               + A+    G + ++   L  P  + AG++  + G      + RA +  L G+  A+
Sbjct: 61  IERVAEARF-APGIIHVIDEPLAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAI 119

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  ++ AG  + GHTE     + ++   M+L T++L+V   +TH+ LR   D +
Sbjct: 120 ATAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDKLKVIHVSTHIALRKFLDTL 179

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           + A +  VI I    L+ + G  +PRI V G+NPHAGE G  G EE   + P + + RA+
Sbjct: 180 STARVETVIGIADTFLK-RVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAK 238

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           GM + GP P DT+F   Y    D V+AMYHDQG   LK  GF  GVNIT GLPFIRTS D
Sbjct: 239 GMDVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSAD 298

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMI 325
           HGTA ++A  GKA   S   ++ LA+++ 
Sbjct: 299 HGTAFDIAWTGKAKSESMAVSIKLAMQLA 327


>UniRef50_C6P2R8 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Sideroxydans
           lithotrophicus ES-1 RepID=C6P2R8_9PROT
          Length = 358

 Score =  397 bits (1020), Expect = e-109,   Method: Composition-based stats.
 Identities = 197/362 (54%), Positives = 242/362 (66%), Gaps = 38/362 (10%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M     +VIT GEPAGIGPDL +QLA  + P  LVV AD +LL +RAA+LG  + L  Y+
Sbjct: 1   MTVLAPLVITAGEPAGIGPDLCLQLAGHDQP--LVVIADKSLLLHRAALLGTGVRLHDYA 58

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            + P +    G L++L V L  P  AG+L   N  YV+ETL RA  GCL+GEF+ ++T P
Sbjct: 59  ADRPLE---NGKLSVLHVPLHRPAQAGKLDSANSPYVLETLRRAVQGCLSGEFSGMVTAP 115

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELR--------------------- 159
           VHKG+INDAGIPFTGHTEF  E++    VVMML    +R                     
Sbjct: 116 VHKGIINDAGIPFTGHTEFLAEQTHTPLVVMMLVGRGMRGRHGDAQHSVREPAQRITDTA 175

Query: 160 ------------VALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCG 207
                       VALATTHLPLR++ADAIT  LL  V+ I+  DL+ +FGIA PRILV G
Sbjct: 176 LAASSENEFVMRVALATTHLPLREVADAITAPLLENVLRIMQRDLQRRFGIARPRILVAG 235

Query: 208 LNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHD 267
           LNPHAGE GH+G EEID +IPVL++LRA+G  ++ PLPADTLF    L + DAVL MYHD
Sbjct: 236 LNPHAGESGHLGREEIDVMIPVLDKLRAEGFNVSPPLPADTLFAAHRLRDCDAVLTMYHD 295

Query: 268 QGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           QGLPVLK+  FG GVNITLGLP IRTSVDHGTALELAG GKA+VGS + A+ +A++M+ N
Sbjct: 296 QGLPVLKHASFGGGVNITLGLPIIRTSVDHGTALELAGTGKAEVGSLLEAIKVAMEMVRN 355

Query: 328 TQ 329
            +
Sbjct: 356 ER 357


>UniRef50_A6DS02 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Lentisphaerae
           RepID=A6DS02_9BACT
          Length = 326

 Score =  396 bits (1019), Expect = e-109,   Method: Composition-based stats.
 Identities = 119/329 (36%), Positives = 182/329 (55%), Gaps = 5/329 (1%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRP 58
           M+K + +++T G+PAG+GP++ V+   +        V+  DA +L+    +      L+P
Sbjct: 1   MMKNKAMILTSGDPAGVGPEVAVKAFAKLANEKFPFVIAGDAYVLSEAIELYAPEFKLKP 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
           Y P    +           +A  +     + + + G    + +  A    +  +++A++T
Sbjct: 61  YIPGEWEE--GVVYYDDFGLAFESSYEKCKASAQCGQLSYDLIVEATHAVIAKQYSAIVT 118

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            PV+K  +N AGI F+GHTE   E  +  +  MM + + LR   AT H+ L+++  A+T 
Sbjct: 119 APVNKESVNLAGITFSGHTELIAELCECPEFNMMQSADRLRCVFATCHIALKEVPKALTV 178

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + +   +LH     + G+ +P++   GLNPHAGE G+MG EEI+T+IP L  LR++G+
Sbjct: 179 DKILQAGRLLHQACLAE-GLVKPKLSAAGLNPHAGENGYMGREEIETVIPALEILRSEGI 237

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            + GP P DTLF P   +  +  L MYHDQG    K   F RGVN TLGLP IRTSVDHG
Sbjct: 238 DIEGPFPPDTLFVPAIRERFEGFLCMYHDQGHIPFKMLAFDRGVNSTLGLPIIRTSVDHG 297

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVN 327
           TA ++A + KAD+GS   AL LA K   N
Sbjct: 298 TAFDIAWQNKADIGSLENALKLAWKRTGN 326


>UniRef50_A3ERM0 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Leptospirillum
           RepID=A3ERM0_9BACT
          Length = 344

 Score =  396 bits (1018), Expect = e-109,   Method: Composition-based stats.
 Identities = 120/328 (36%), Positives = 174/328 (53%), Gaps = 7/328 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQ--LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            + IT G+PAGIGP+++V+  L      +  +V  D  L+   A      L ++      
Sbjct: 14  PLAITMGDPAGIGPEIIVKGWLENEIRDLPRIVIGDPDLIAEVARKYSPELLVQQIDSPE 73

Query: 64  PAQPQTAGTLTLL---PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            A P+  G L +L      +  PV+ G   V  G +    +    +  + G  A ++T P
Sbjct: 74  HA-PRDPGILGVLLPEHEDILEPVSPGTSQVMAGRWAYYCVRTGVELAMAGRVAGIVTAP 132

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           ++K V++ AG  + GHTE     +   +  MML    L+V L TTH+P R+IA  IT   
Sbjct: 133 LNKKVLHAAGFNYPGHTELIAHLTNTPRYGMMLVGGPLKVILVTTHIPFREIAGKITKER 192

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           + E I +    +     IA P+I V  LNPHAGE    G EE   I P + E RA+G+++
Sbjct: 193 VLETIQLAREAMDM-LKIASPKIAVAALNPHAGEASLFGDEEKTCIFPAILEARAEGIEV 251

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GPLPADTL+        D V++ YHDQGL  LK   FG+G+N+T+G+P IRTSVDHGTA
Sbjct: 252 EGPLPADTLYAKAAQGRFDIVVSQYHDQGLIPLKMLSFGQGINVTVGIPIIRTSVDHGTA 311

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNT 328
            ++ G+G A  GS I A+ LA ++    
Sbjct: 312 YDIVGKGIAQPGSLIKAIRLAGQLTEGR 339


>UniRef50_Q1NMK1 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Proteobacteria
           RepID=Q1NMK1_9DELT
          Length = 340

 Score =  392 bits (1009), Expect = e-108,   Method: Composition-based stats.
 Identities = 132/333 (39%), Positives = 176/333 (52%), Gaps = 11/333 (3%)

Query: 4   TQRVVITPGEPAGIGPDLVVQ----LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
              + IT G PAGIGP+++++    LA       LVV  D  +L + A  LG  + LR +
Sbjct: 7   PPPIGITMGCPAGIGPEIILRFWSELATAGQRRSLVVLGDPGVLAHNARQLGFKVPLRVW 66

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
            P     P     L +    L AP   G+   E+G  +   +  AC   + GE  A++T 
Sbjct: 67  HPQEAPNPAALNILPV--SELSAPPPWGRPTPESGRAMGRYIVEACRLAMGGELTAMVTC 124

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P+ K ++N  G  + GHTE      ++ +  MM+A   LRV LAT H PL  +  A+ PA
Sbjct: 125 PIGKEMLNAGGYHYPGHTEMLAALCKSPEYAMMMAGHRLRVVLATIHCPLTAVPAALEPA 184

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTI----IPVLNELRA 235
            LH ++ +    LR  F I  PR+ V GLNPHAGEGG  G EE   I         EL  
Sbjct: 185 KLHHLLRLTVAALRRDFAIPAPRLAVAGLNPHAGEGGMFGHEEKTVIAPAVAAAAAELGG 244

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G +L GP P DT+F      + DAV+AMYHDQGL   K   F  GVN+TLGLP +RTSV
Sbjct: 245 KG-ELVGPRPPDTVFHQAAAGHFDAVVAMYHDQGLIPFKLLHFSDGVNVTLGLPVVRTSV 303

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           DHGTA ++AGRG AD  S   A  LA ++  + 
Sbjct: 304 DHGTAYDIAGRGLADPASLAAAFQLATEIAAHR 336


>UniRef50_B7UKV9 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=15
           Tax=Enterobacteriaceae RepID=B7UKV9_ECO27
          Length = 328

 Score =  392 bits (1007), Expect = e-107,   Method: Composition-based stats.
 Identities = 117/325 (36%), Positives = 173/325 (53%), Gaps = 7/325 (2%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPV--ELVVCADATLLTNRAAM-LGLPLTLRPYSPNS 63
           + +T G+PAGIGP+++++           +VV      L    AM +     LR      
Sbjct: 5   IAVTMGDPAGIGPEIIIKSLSEAGLAGTPVVVVGCVRTLRRIMAMNITPQAELRVIQKVC 64

Query: 64  PAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            A     G + ++   L  P  +T G +    G      + RA    L+GE  A+ T P+
Sbjct: 65  DAHF-APGVINVMDEPLANPDALTPGVVQAAAGDLAYRCIKRATALALSGEVKAIATAPL 123

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           +K  ++  G  + GHTE     + +K+  M+L T++L+V   +TH+ LR   D +    +
Sbjct: 124 NKEALHLGGHNYPGHTELLAHLTGSKEYAMVLYTDKLKVIHISTHISLRKFLDTLNGERV 183

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
             VI + +H L+ + GI  PRI V G+NPHAGE G  GTEEI+ I P +  ++A+ + + 
Sbjct: 184 KTVIRVANHFLK-RVGIERPRIAVAGVNPHAGEHGLFGTEEIEIIAPAIEAMQAEDIDVT 242

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP P DT+F   +    D V+AMYHDQG   LK  GF  GVNIT GLPFIRTS DHGTA 
Sbjct: 243 GPCPPDTVFMQCHEGLFDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTAF 302

Query: 302 ELAGRGKADVGSFITALNLAIKMIV 326
           ++A  GKA   S   ++ LA+++  
Sbjct: 303 DIAWTGKAKSESMAVSIQLAMQISR 327


>UniRef50_B2IDU5 4-hydroxythreonine-4-phosphate dehydrogenase n=29 Tax=cellular
           organisms RepID=PDXA_BEII9
          Length = 337

 Score =  391 bits (1005), Expect = e-107,   Method: Composition-based stats.
 Identities = 125/326 (38%), Positives = 179/326 (54%), Gaps = 4/326 (1%)

Query: 5   QRVVITPGEPAGIGPDLVVQL-AQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
             + +T G+P+GIGP+++ ++  +R      +V  D  ++ +  A LG+ + +R  +   
Sbjct: 6   HPLAVTMGDPSGIGPEIIAKMYLRRPDKRNWIVVGDPLVMEHAIANLGVAVQIRRIATVE 65

Query: 64  PAQPQTAGTLTLLPVALRAPVTA-GQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
            A  +  G L +L  +  A + A G+++  +G    + +  A      G    ++T P+H
Sbjct: 66  EAGCED-GVLNVLASSSLATLPAVGRVSAVSGQAAYDAIVTAIGLARQGTIRGIVTAPIH 124

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K  +  AGI + GHTE   E+  A+ V MMLA +E+R  L T H  L D           
Sbjct: 125 KEALAAAGIHYPGHTEILAEQGGAQHVAMMLANDEIRTVLVTIHCSLADAIRKADFPAQM 184

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
           + I + H   R   GI +PRI V GLNPHAGEGG  G EEI  I P +   RA+G+   G
Sbjct: 185 QAIRLAHEGARA-LGIVQPRIAVAGLNPHAGEGGLFGDEEIRIITPAIAAARAEGIDATG 243

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
           P P DT+F    L   D V+A YHDQGL  +K+ G  +GVNITLGLPF+RTS DHGTA +
Sbjct: 244 PWPGDTVFMQARLGKFDVVVAQYHDQGLIPVKFMGLEKGVNITLGLPFVRTSPDHGTAFD 303

Query: 303 LAGRGKADVGSFITALNLAIKMIVNT 328
           +AGRG AD  S  TA + A ++ V T
Sbjct: 304 IAGRGIADSSSLETAFDYATRLKVPT 329


>UniRef50_A5CWR9 4-hydroxythreonine-4-phosphate dehydrogenase n=8
           Tax=Gammaproteobacteria RepID=A5CWR9_VESOH
          Length = 332

 Score =  390 bits (1002), Expect = e-107,   Method: Composition-based stats.
 Identities = 161/323 (49%), Positives = 204/323 (63%), Gaps = 6/323 (1%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           +  T GEP+GIGPDL V  AQ +    L++  D  +L NRA  L L + +         Q
Sbjct: 4   IAFTVGEPSGIGPDLAVIYAQIKSNKNLLLFTDPDVLLNRAKQLNLNIKI-----IEAEQ 58

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
             +   L + P+ +   V  G L  +N  YV+ TL  A + CLN    AL+TGP+HKG+I
Sbjct: 59  AGSNYELAVYPIKVNTHVECGILNKDNAQYVLNTLDCATEYCLNSRCDALVTGPIHKGII 118

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIA 186
           N AGI FTGHTE+    S   K VMMLAT  LRVALATTH+PL D+   IT   L + I+
Sbjct: 119 NQAGINFTGHTEYLANLSNIDKTVMMLATNGLRVALATTHMPLSDVPQNITTQSLKKTIS 178

Query: 187 ILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPA 246
           I+H  L    G+  P+I+VCGLNPHAGE G++G EEI+ I P++ EL +QG  L G +PA
Sbjct: 179 IIHQFLLNN-GVNTPKIVVCGLNPHAGENGYLGMEEIEIINPLIKELNSQGYNLVGSIPA 237

Query: 247 DTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGR 306
           DT F P  L   D VL+MYHDQGLPVLK  GF + VNITLGLPFIRTSVDHG+AL LAG 
Sbjct: 238 DTAFTPNSLTGVDCVLSMYHDQGLPVLKTLGFKKAVNITLGLPFIRTSVDHGSALNLAGT 297

Query: 307 GKADVGSFITALNLAIKMIVNTQ 329
           G   +GS  TA+N A  +++N +
Sbjct: 298 GNISLGSLNTAINYAQMLVINHK 320


>UniRef50_C9LG48 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Bacteroidales
           RepID=C9LG48_9BACT
          Length = 386

 Score =  388 bits (998), Expect = e-106,   Method: Composition-based stats.
 Identities = 123/328 (37%), Positives = 167/328 (50%), Gaps = 8/328 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           +V IT G+  G+G +L+ Q        E    +V     +       LGL    +    +
Sbjct: 27  KVGITHGDTNGVGYELIFQTFGNPTMFEMCTPIVYGSPQIANAHKKALGLQFNYQIIEDS 86

Query: 63  SPAQPQTAGTLTLLP-VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           + A     G L L+  V    PV  GQ     G      L RA      G+   L+T P+
Sbjct: 87  ARA---VDGQLNLIDCVKKDVPVNLGQPDKAAGFAAYCALERATADLREGKIDVLVTAPI 143

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAK-KVVMMLATEELRVALATTHLPLRDIADAITPAL 180
            K  I      FTGHTE+ ++R Q + + +M+L   +LRVAL TTHLPL ++A AIT   
Sbjct: 144 DKFTIQSDDFHFTGHTEYLQDRLQGEYEPLMILMNGQLRVALVTTHLPLSEVAPAITAER 203

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +   + +L   LRT F +  PRI V  LNPH G+ G +G+EE + I PV+ +L  +G  +
Sbjct: 204 VELKLRLLQRSLRTDFLLPMPRIAVLSLNPHCGDKGTIGSEEANIIKPVIEKLVKEGKNV 263

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP PAD  F  +     DAVLAMYHDQGL   K      GVN T GL  +RTS DHG A
Sbjct: 264 FGPYPADGFFGSELHRRFDAVLAMYHDQGLAPFKALAMEEGVNFTAGLSAVRTSPDHGVA 323

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNT 328
            ++AG+G A V SF +A+  AI +  N 
Sbjct: 324 YDIAGKGVASVASFRSAVYSAIDIYRNR 351


>UniRef50_C1SJH6 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Denitrovibrio
           acetiphilus DSM 12809 RepID=C1SJH6_9BACT
          Length = 322

 Score =  387 bits (995), Expect = e-106,   Method: Composition-based stats.
 Identities = 117/328 (35%), Positives = 175/328 (53%), Gaps = 10/328 (3%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           +K  ++ IT G+P+GIGP++  +LA      E             A  +     ++    
Sbjct: 3   MKKPKIAITTGDPSGIGPEIACRLASELDGSE----------EYDAVFISYENVIKSAFE 52

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           N    P    T+      L   +  G +  E G   +  + +A    ++GE  A++T P+
Sbjct: 53  NIIKAPMPEMTIIEPDEKLDLKIEHGLIKPEYGKASMLYVEKAVQMAMSGEVDAVVTCPI 112

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           +K  I   G  + GHTEF    ++ +   M++  + +R  LATTH+P+ ++ D +    +
Sbjct: 113 NKASIKAGGYNYPGHTEFLGYLTRTRYFSMLMVGKNIRTVLATTHVPMAELVDKLDENSI 172

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
              I   H   +   G  +P+I VCGLNPHAG+ G +G EEI  I PV++  RA GM + 
Sbjct: 173 MNAIVNAHEAGQFFCGKRQPKIAVCGLNPHAGDNGALGDEEITLITPVIDIARAGGMDVE 232

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP PAD+LF        D V+ MYHDQGL  +K + FG  VN+TL LP IRTSVDHGTA 
Sbjct: 233 GPFPADSLFPKAAKGEYDFVVVMYHDQGLIPVKLEAFGNAVNVTLNLPIIRTSVDHGTAF 292

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNTQ 329
           E+AG+G AD  S I A+++A++M+ N Q
Sbjct: 293 EIAGKGIADHHSLIRAIDVAVEMVKNAQ 320


>UniRef50_Q89NF3 4-hydroxythreonine-4-phosphate dehydrogenase 1 n=8
           Tax=Proteobacteria RepID=PDXA1_BRAJA
          Length = 345

 Score =  387 bits (994), Expect = e-106,   Method: Composition-based stats.
 Identities = 120/343 (34%), Positives = 179/343 (52%), Gaps = 21/343 (6%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQ------REWPVELVVCADATLLTNRAAMLGLPLT 55
           + ++ + IT G+PAGIGP+++V+             + L++      L    A LG  + 
Sbjct: 1   MTSRHLAITMGDPAGIGPEIIVKACLGLKGRIATGDLRLLIIGSGAALDGAKAALGTDVA 60

Query: 56  LRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
           +   S +    P       L   A   P+  G L+ + G +  + + +       G  AA
Sbjct: 61  IPQVSADDREWPNLC---YLQADAEGDPIKPGVLSADGGRFAYKAIEQGVRLTQAGRTAA 117

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           ++T P++K  +N AG  F GHTE     +  +  VM+LA   +RV+  +TH+ L D+   
Sbjct: 118 IVTAPLNKEALNKAGYHFPGHTEMLAHLTGVRGSVMLLAHGNMRVSHVSTHVALEDVPKR 177

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           +TP  L  VI + +  LR + GIA+P+I V  LNPHAGEGG  G ++ID   P + +  A
Sbjct: 178 LTPERLRMVIDLTNDALR-RLGIAKPKIAVAALNPHAGEGGLFGRQDIDVSAPTIAKAVA 236

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFG-----------RGVNI 284
            G+ + GP+P DT+F        DA +AMYHDQG   +K  GF             GVNI
Sbjct: 237 DGLDVIGPVPGDTIFVKLRAGQFDAAVAMYHDQGHIPVKLLGFQVDPATGRWQELSGVNI 296

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           TLGLP IRTSVDHGTA ++AG+G A+  S I A++ A ++   
Sbjct: 297 TLGLPIIRTSVDHGTAFDIAGKGIANEHSLIEAIDYAERLAAG 339


>UniRef50_B5YL57 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Thermodesulfovibrio yellowstonii DSM 11347
           RepID=B5YL57_THEYD
          Length = 316

 Score =  387 bits (994), Expect = e-106,   Method: Composition-based stats.
 Identities = 112/326 (34%), Positives = 173/326 (53%), Gaps = 15/326 (4%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRP 58
           +  +R+ IT G+PAG+GP+++V+   +E        +V  D  ++     ++G+   L  
Sbjct: 1   MAKKRIAITMGDPAGVGPEIIVKAFAQEDIYKICNPIVIGDKAVIKELIKVIGMDFDLDN 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                         L L  +   + +  G  + E+G      + +A +    G   A++T
Sbjct: 61  IE-----------MLNLNEIKNPSKLLKGTPSEESGRACFSYIRKAVELYRLGVVQAIVT 109

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P+ K  +  AG+P+ GHT+   E +  +   M   +E L+V L T H+PL+++   I  
Sbjct: 110 CPITKVALKMAGLPWLGHTDMLAELTDTEDYAMAFYSEHLKVILVTIHVPLKEVPYLIKK 169

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + + I            I  PRI VCGLNPHAGE G +G EEI+ I P + E +A G+
Sbjct: 170 ENVIKSICFAKKACDM-LRIENPRIAVCGLNPHAGEEGIIGREEIEEITPAIKETKALGI 228

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            ++GP P+D+LF   Y    D V+AMYHDQ L   K   F +GVN T+GLPFIRTS DHG
Sbjct: 229 NVSGPYPSDSLFWRAYKGEFDMVVAMYHDQALAPFKLVAFDKGVNFTVGLPFIRTSPDHG 288

Query: 299 TALELAGRGKADVGSFITALNLAIKM 324
           TA ++A +GKA+  S + A+ LA++M
Sbjct: 289 TAYDIAWQGKAEPTSLLEAIKLAVRM 314


>UniRef50_C4X874 4-hydroxythreonine-4-phosphate dehydrogenase n=15 Tax=Bacteria
           RepID=C4X874_KLEPN
          Length = 328

 Score =  386 bits (993), Expect = e-106,   Method: Composition-based stats.
 Identities = 120/327 (36%), Positives = 173/327 (52%), Gaps = 7/327 (2%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQRE--WPVELVVCADATLLTN-RAAMLGLPLTLRPYS 60
           ++ + +T G+PAGIGP+++++           +VV   A  L    A  +     LR   
Sbjct: 2   SKMIAVTMGDPAGIGPEIIIKSLAEGALSGAPVVVVGCAQTLRRILALNITPRAELRIID 61

Query: 61  PNSPAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
             + A    A T+ ++   L  P  +  G++  + G      + RA    L G  AA+ T
Sbjct: 62  HPAEASFSPA-TINVIDEPLSDPQGLRPGEVQAQAGDLAFRCIRRATALALEGAVAAIAT 120

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P++K  ++ AG  + GHTE     +Q     M+L TE+L+V   TTH+ LR   D +  
Sbjct: 121 APLNKEALHLAGHAYPGHTELLAHLTQTTDYAMVLYTEKLKVIHITTHISLRQFLDTLNQ 180

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             +  VI +    LR + G   PRI V G+NPHAGE G  G EEI  + P +  +RA+G+
Sbjct: 181 PRIETVIGVADRFLR-RVGYPRPRIAVAGVNPHAGENGLFGDEEIRIVAPAVAAMRAKGV 239

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           ++ GP P DT+F   +    D V+AMYHDQG   LK  GF  GVNIT GLPFIRTS DHG
Sbjct: 240 EVTGPCPPDTVFMQCHEGMYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHG 299

Query: 299 TALELAGRGKADVGSFITALNLAIKMI 325
           TA ++A  GKA   S  T++ LA+ + 
Sbjct: 300 TAFDIAWTGKAKSESMATSIELAMHIA 326


>UniRef50_UPI0000E87C06 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Methylophilales bacterium HTCC2181
           RepID=UPI0000E87C06
          Length = 324

 Score =  386 bits (992), Expect = e-106,   Method: Composition-based stats.
 Identities = 136/322 (42%), Positives = 192/322 (59%), Gaps = 5/322 (1%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
            +++I  G+P+GIG DL+V LA++ +   + + A+   L  RA + G  L  +     + 
Sbjct: 6   PKIIINCGDPSGIGLDLIVFLAEKPFNASITILANKESLVQRAGLHGKKLAFQ----ENV 61

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
           +  +  G L +  +     V  G     N    ++ +  A   C+   + AL+T P+ K 
Sbjct: 62  SLHKGDGRLYVKNIHYENDVIPGLPNKHNSKAQMQMIDHAVKECMAMNYDALVTLPISKE 121

Query: 125 VINDAGIPFTGHTEFFEERSQAKK-VVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
           +++D+   FTGHTE+  + S  K   VMML   +LRVALATTH+PL D+   IT   L +
Sbjct: 122 ILSDSNNKFTGHTEYIAKLSNIKNQEVMMLVHNKLRVALATTHIPLSDVPKTITREKLEK 181

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
           +I  LH+DL+TKF +  PRI V GLNPHAGE G  G EE+  +IP++N+L  QG  L GP
Sbjct: 182 IILTLHNDLKTKFKVLSPRITVTGLNPHAGENGEFGNEELTVLIPIINKLNEQGCNLVGP 241

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           +PADT F P ++   DA LAM+HDQGL   K   FG+GVNITLGLPFIRTSVDHGTA ++
Sbjct: 242 IPADTAFTPGHIKKTDAFLAMFHDQGLAPFKALSFGKGVNITLGLPFIRTSVDHGTAFDI 301

Query: 304 AGRGKADVGSFITALNLAIKMI 325
            G  + D  SF  A+  AI++ 
Sbjct: 302 VGSKEIDPSSFYEAIFTAIELS 323


>UniRef50_A6GTC8 Pyridoxal phosphate biosynthetic protein PdxA n=1 Tax=Limnobacter
           sp. MED105 RepID=A6GTC8_9BURK
          Length = 340

 Score =  385 bits (990), Expect = e-105,   Method: Composition-based stats.
 Identities = 157/334 (47%), Positives = 202/334 (60%), Gaps = 8/334 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLA----QREWPVELVVCADATLLTNRAAMLGLPLTLRP 58
               ++IT GEPAGIGP+L   LA     +     LV+  DA LL  RA   G+    + 
Sbjct: 5   TNLPILITSGEPAGIGPELCALLAETSQAKRLNRSLVILGDADLLETRAKNAGIEPKWQR 64

Query: 59  YS---PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
            +     +  +P+  G   LL   L  P   GQ    N  YV+  L  ACD C NG  AA
Sbjct: 65  INSLRDIATGEPEAPGYF-LLDHPLSTPCITGQPNPANAPYVLGLLNMACDACQNGTAAA 123

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           ++T P+ K  I+     F GHTE+  ER     VVMML   +++VALATTH+PL  + +A
Sbjct: 124 MVTAPIQKSAISPHWPGFMGHTEYLAERCGQGDVVMMLIGGQMKVALATTHIPLAKVPEA 183

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           IT + L   + I+ HDL   + + +PRILV GLNPHAGE G +G EEIDTI P +  L+A
Sbjct: 184 ITRSSLTRTLEIMLHDLSLYWSLPKPRILVTGLNPHAGESGDLGREEIDTITPTIKALQA 243

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G  + GP PADTLFQPKYL N+DAVLAM+HDQGLPVLK+  FG+GVN++LGLP +RTSV
Sbjct: 244 RGHDVQGPFPADTLFQPKYLQNSDAVLAMFHDQGLPVLKHASFGQGVNVSLGLPIVRTSV 303

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           DHGTAL+LAG    D GS   A+  A  M +  +
Sbjct: 304 DHGTALDLAGTRNMDAGSLNEAIECAHHMDLCRR 337


>UniRef50_C6E7W5 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Geobacter
           RepID=C6E7W5_GEOSM
          Length = 348

 Score =  385 bits (990), Expect = e-105,   Method: Composition-based stats.
 Identities = 119/315 (37%), Positives = 153/315 (48%), Gaps = 6/315 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPYS 60
              + +T G+P GIGP+++               +V  D   +    A+ G+ L +    
Sbjct: 17  KPVIAVTMGDPCGIGPEIIAAALADPAITSLCRPLVIGDREAMERGIAVAGVKLAVASAP 76

Query: 61  PNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
              P      GTL L  ++      +  G      G      +  A   CL+G   A+ T
Sbjct: 77  DLLPPAIVAPGTLYLRELSRLKLDEIPYGAPTTAGGDACYRYICEAARLCLDGTAQAMAT 136

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P++K  +N AG  + GHTE   E +   +VVMMLA E LRV L T H PL  + + +T 
Sbjct: 137 APINKESMNSAGHDYPGHTELLAELTGTPEVVMMLAGERLRVTLVTIHEPLARVPELVTF 196

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             +   I I H  L   F    PR+ V  LNPH GEGG  G EE   I P +   R  G+
Sbjct: 197 DRVLSTIRITHDALSRWF-CRAPRLAVLALNPHCGEGGMFGDEESRIIAPAVAAAREAGI 255

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
              GP+ ADTLF        DAV+ MYHDQGL  LK   F  GVN+TLGLP IRTSVDHG
Sbjct: 256 DAAGPVSADTLFHFAAKGGYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDHG 315

Query: 299 TALELAGRGKADVGS 313
           TA +LAG GKA   S
Sbjct: 316 TAYDLAGTGKASAES 330


>UniRef50_Q8D3I2 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Gammaproteobacteria RepID=PDXA_WIGBR
          Length = 332

 Score =  385 bits (989), Expect = e-105,   Method: Composition-based stats.
 Identities = 168/325 (51%), Positives = 222/325 (68%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M K  R++ITPGEPAGIG DLVV ++Q+ W  ELV+C D  +L  RA   G+ L L  Y+
Sbjct: 1   MNKISRIIITPGEPAGIGFDLVVLISQKIWRSELVICCDPDILVKRAKDHGIKLKLHFYN 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            N   + +  G LT++P+ + + VT G L + N +YV+ TL RAC GC+N EF+AL+TGP
Sbjct: 61  KNLSPKVREKGELTIIPIKVNSNVTRGILNINNSYYVINTLTRACLGCINKEFSALVTGP 120

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           VHKG+I D+GI F GHTEF    S  K  VMML    LR+ALAT H+P++DI+  I   L
Sbjct: 121 VHKGIIKDSGIKFIGHTEFLAGFSLCKNPVMMLMYNSLRIALATNHIPIKDISKCINFNL 180

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           + + + ++ + LR  F I  P I VCGLNPHAGE GH+GTEEI+ I P ++ L+    K+
Sbjct: 181 IRKKLIVIFNSLRNIFKINNPCIYVCGLNPHAGESGHIGTEEINIIQPAISSLKYLPCKI 240

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+ AD++FQ KYL +ADA+LAMYHDQGLP++KY GF + VNITLGLPFIRTSVDHGTA
Sbjct: 241 IGPISADSIFQQKYLKDADAILAMYHDQGLPMIKYIGFRKSVNITLGLPFIRTSVDHGTA 300

Query: 301 LELAGRGKADVGSFITALNLAIKMI 325
           L +    +    S   A++LAI + 
Sbjct: 301 LNIKNLNEISSKSMEKAISLAIDIS 325


>UniRef50_A6L8G2 4-hydroxythreonine-4-phosphate dehydrogenase n=7 Tax=Bacteroidales
           RepID=A6L8G2_PARD8
          Length = 369

 Score =  382 bits (983), Expect = e-105,   Method: Composition-based stats.
 Identities = 111/329 (33%), Positives = 158/329 (48%), Gaps = 8/329 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLP-LTLRPYSP 61
           +V IT G+  GIG +++++        EL   ++   + +       L LP + +   S 
Sbjct: 7   KVGITHGDINGIGYEVILKTFSDTRMAELCTPIIYGSSKIAAYHRKALELPPINMNIISH 66

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
              A       +    V     V   +     G    + L  A      G    L+T P+
Sbjct: 67  AEDAGVNRVNIINC--VEDETKVELSKSTPVAGESAFKALEAAVTDMKRGVVDVLLTAPI 124

Query: 122 HKGVINDAGIPFTGHTEFFEERSQA--KKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           +K  I +    F GHTE+ E+      KK +M+L  ++LRVAL T H+PL  +A ++   
Sbjct: 125 NKHNIQNEDFHFPGHTEYLEKCFGGLDKKALMILMKDDLRVALVTGHIPLSQVASSLNVG 184

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +   + I +  L+  FGI +PRI V  LNPHAG+ G +GTEE   IIP + E   +G+ 
Sbjct: 185 DIVNKLRIFNQSLKQDFGIVKPRIAVLSLNPHAGDAGLLGTEEETIIIPAMQEAEKKGVM 244

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
             GP  AD  F  +  D  D VLAMYHDQGL   K      GVN T GLP +RTS  HGT
Sbjct: 245 SFGPYAADGFFGSQMYDKFDGVLAMYHDQGLAPFKTLAMDDGVNYTAGLPIVRTSPAHGT 304

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           A ++AG+  A   SF  AL  A+ +  N 
Sbjct: 305 AYDIAGQNVASEESFRQALYAALDIFRNR 333


>UniRef50_A7HYG3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Alphaproteobacteria RepID=A7HYG3_PARL1
          Length = 340

 Score =  381 bits (980), Expect = e-104,   Method: Composition-based stats.
 Identities = 141/329 (42%), Positives = 182/329 (55%), Gaps = 5/329 (1%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSP 61
             + ++ GEPAGIGP++ ++              V  D  L    +  LG    +R  S 
Sbjct: 9   PPLALSMGEPAGIGPEITLKAWAARAEKSLPIFFVAGDPALYRTASERLGAGAAIREISD 68

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            S A     G L +LPV L    T GQL+  N   V+ ++  ACD    G+ + L+T P+
Sbjct: 69  PSEAAEVFPGALPVLPVPLHEAATPGQLSGANAAAVLASIDTACDAVTAGKASGLVTNPI 128

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           HK V+ DAG    GHTE+  ER+   K VMML+   LRV   T HL L+D    +T + +
Sbjct: 129 HKRVLYDAGFHVPGHTEYLAERTGGAKPVMMLSCPGLRVVPVTVHLSLKDAVAVLTTSEI 188

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ--GMK 239
            E   IL   L   FGI++PRI +  LNPHAGE GH+G EEID I P    L     G +
Sbjct: 189 VEHGLILSRSLTADFGISKPRIAIAALNPHAGEEGHLGREEIDIIAPAAKLLAEALPGAE 248

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           ++GPLPADTLF        DAVL MYHDQ L  LK   F RGVNITLGLP +RTS DHGT
Sbjct: 249 ISGPLPADTLFHAAARARHDAVLCMYHDQALIPLKTIDFARGVNITLGLPIVRTSPDHGT 308

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           AL++AGRG AD  S I A+ +A ++  + 
Sbjct: 309 ALDIAGRGVADPESLIEAILVADEITRHR 337


>UniRef50_C7M3J3 4-hydroxythreonine-4-phosphate dehydrogenase n=6 Tax=Flavobacteria
           RepID=C7M3J3_CAPOD
          Length = 352

 Score =  381 bits (979), Expect = e-104,   Method: Composition-based stats.
 Identities = 109/332 (32%), Positives = 170/332 (51%), Gaps = 9/332 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPY 59
           K  +V I+ G+  G+G +++++  +    +EL   ++ A   L++ +          +  
Sbjct: 4   KPIKVGISIGDMNGVGLEIILKTFEDHQILELCTPIIFASNKLVSFQKKHFNTTANFQGI 63

Query: 60  SPNSPAQPQTAGTLTLLPVALRAP-VTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                A     G L +L      P VT GQ   E G Y   +L  A +   N     L+T
Sbjct: 64  ESVEAA---IDGKLNVLNCWKETPTVTFGQETEEGGKYAFLSLQAAVEALKNNSIDVLVT 120

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P++K  I      F GHT++  +       +M + +E+L+V L T H+PL++++  IT 
Sbjct: 121 APINKNNIQSDAFHFPGHTDYLAQELNGTS-LMFMVSEDLKVGLLTDHVPLKEVSSLITE 179

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL-RAQG 237
           AL+ E   +++  L   F +  P+I V G+NPH G+ G +G E+ + + P L +L   + 
Sbjct: 180 ALIMEKARLMNESLIKDFRLQRPKIAVLGINPHCGDKGVIGNEDDEVLRPALKKLYFDEN 239

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           + + GP  AD+ F  +   N DAVLA YHDQGL   K   FG GVN T GL  +RTS DH
Sbjct: 240 ILVFGPFAADSFFGSQTYRNYDAVLAPYHDQGLIAFKTIAFGSGVNYTAGLSKVRTSPDH 299

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           GTA E+AG+G AD  SF  A+  A+ +  N +
Sbjct: 300 GTAYEIAGKGIADPESFRHAIFTALDVFRNRE 331


>UniRef50_Q1GI38 4-hydroxythreonine-4-phosphate dehydrogenase n=30
           Tax=Proteobacteria RepID=PDXA_SILST
          Length = 326

 Score =  380 bits (978), Expect = e-104,   Method: Composition-based stats.
 Identities = 134/328 (40%), Positives = 180/328 (54%), Gaps = 9/328 (2%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
            Q + ++ GEPAGIGP++ V    +       V   D   L +           +P S  
Sbjct: 5   PQVIALSCGEPAGIGPEIAVAAWDQLRADCPFVWIGDPRHLPS-------SHPWQPVSAP 57

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
           + A   +A  L + P+      T G+   +N   V++++    +   +G+ AAL T P+H
Sbjct: 58  AEALQVSADALPVWPLEFAGNTTKGEADPQNASGVIQSIKTGVELVTSGKAAALCTAPIH 117

Query: 123 KGVIND-AGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           K  + D AG  + GHTEF         VVMMLA+  LRV  AT H+PL  + + +TP  L
Sbjct: 118 KKALIDGAGFAYPGHTEFLAALGGVDHVVMMLASAALRVVPATIHIPLSAVPEVLTPDHL 177

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
             VI +    LR +FG+  PRI V GLNPHAGEGG MG EE D I  ++ E++ +G +L 
Sbjct: 178 RRVITLTDRGLRDQFGLTAPRIAVTGLNPHAGEGGAMGQEEGDWIEALIREMQTEGYRLT 237

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP PADTLF        DA +AMYHDQ L  +K   F +GVN+TLGLPFIRTS DHGTA 
Sbjct: 238 GPHPADTLFHAAARARYDAAIAMYHDQALIPIKTLDFDKGVNVTLGLPFIRTSPDHGTAF 297

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNTQ 329
           ++AG+G A+  S I AL LA  M    Q
Sbjct: 298 DIAGKGLANPSSLIEALRLAQTMAKTRQ 325


>UniRef50_C6XHX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Liberibacter asiaticus str. psy62 RepID=C6XHX7_LIBAP
          Length = 343

 Score =  379 bits (975), Expect = e-104,   Method: Composition-based stats.
 Identities = 109/332 (32%), Positives = 167/332 (50%), Gaps = 9/332 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPV---ELVVCADATLLTNRAAMLGLPLTLR 57
           M +   +++T G+PAGIGPD+ ++             +   D  +L  RA  L L + L 
Sbjct: 1   MDEFLPLILTQGDPAGIGPDISLKAWASRQITAIPPFIYIGDVDVLNARAKQLNLSVPLY 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                + A       L ++     A +  G    +     +  + +A    L+G+  A++
Sbjct: 61  ETDCKN-AVSIFKKALPIISSPCGAKIVTGTPNPQTASSTIANIEKAVSLTLSGQALAIV 119

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAK-----KVVMMLATEELRVALATTHLPLRDI 172
           T P+ K ++      F GHTEF  E ++       K VMML+  +LR    T H+P+ DI
Sbjct: 120 TNPIAKFLLYQEKFKFPGHTEFLAELAKKNTGITFKPVMMLSGPQLRTVPVTIHIPIADI 179

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
              ++   + E    +++ ++  FGI  PRI + GLNPHAGE   +G EE + IIP +  
Sbjct: 180 CRILSTKRIIETSDTVYNAMKKYFGINNPRIAISGLNPHAGENATIGIEEKNIIIPAITY 239

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
           LR     + GPLPAD++F        D  + MYHDQ L  +K   F + VNITLGLPF+R
Sbjct: 240 LRNDNKNIIGPLPADSMFHHSARQCYDVAICMYHDQALIPIKTLDFNQTVNITLGLPFVR 299

Query: 293 TSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           TS DHGTA ++AG       S ++AL +A ++
Sbjct: 300 TSPDHGTAFDIAGSSLTQEESLVSALKIAAQL 331


>UniRef50_C7PP38 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Bacteria
           RepID=C7PP38_CHIPD
          Length = 354

 Score =  379 bits (974), Expect = e-104,   Method: Composition-based stats.
 Identities = 103/332 (31%), Positives = 153/332 (46%), Gaps = 6/332 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLG-LPLTLR 57
                + IT G+   IG +L+++       +E    V+ A    +     ++       +
Sbjct: 7   TNKPVIGITVGDINSIGTELIIKTFADARMLEFCTPVIFASNKTINFYRKLMNENNFNYQ 66

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                +    +               +T G L    G Y   +LA A +    G    LI
Sbjct: 67  SVKEFARLNHKQVNVFNCWE--EEVQITPGVLNEVGGKYAARSLAVAIECLKEGHIQGLI 124

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           T P+HK  I      +TGHT +  +   AK V+M +  + +RV L T H+P+ +I+  + 
Sbjct: 125 TAPIHKKNIQGEQFNYTGHTPYLRDAFDAKDVLMFMTADNMRVGLLTEHVPVAEISKYVK 184

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              +   + ++   L   FGI  PRI V GLNPHAG+ G +G EEI  IIP +   +  G
Sbjct: 185 KDNILAKLQMMEDSLIKDFGIDSPRIAVLGLNPHAGDDGLIGQEEITEIIPAIKHAKNNG 244

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           +   GP  AD  F     +  D VLAMYHDQGL   K    G G+N T GLP +RTS DH
Sbjct: 245 LLCFGPYSADAFFARNMHEQFDGVLAMYHDQGLIPFKSLATGNGINYTAGLPIVRTSPDH 304

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           GTA ++AG+  AD  SF  A+   + ++   +
Sbjct: 305 GTAFDIAGKNLADHNSFRQAIFTCLDILEKRE 336


>UniRef50_C6X2C9 4-hydroxythreonine-4-phosphate dehydrogenase n=3
           Tax=Flavobacteriales RepID=C6X2C9_FLAB3
          Length = 363

 Score =  378 bits (972), Expect = e-103,   Method: Composition-based stats.
 Identities = 119/331 (35%), Positives = 179/331 (54%), Gaps = 6/331 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRP 58
               RV I+ G+  GIGP+++++  + +   +    ++     L T +  +  L +    
Sbjct: 5   PHKVRVGISIGDFNGIGPEIIMKTLKDKSITDFFTPIIFGSGKLFTYQKNIFKLQINFNY 64

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
            +    AQ      + L   A    V  G+   E+    +E+L  A D  + G+   L+T
Sbjct: 65  ITEALQAQSDKINMVNL--TADNVNVDLGKPTEESTRMAIESLEAATDALVRGDIDVLVT 122

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P++K  +   G    GHT + EE+ Q KK +M L +E L+VA++T H+P+  +A+ I+ 
Sbjct: 123 APINKDEMIKHGFAHAGHTGYLEEKFQ-KKGLMFLVSEGLKVAVSTHHIPISQVAENISK 181

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + + I IL+  L   F I+ P+I V GLNPHAG+GG +G EEI+ I P + ++   G+
Sbjct: 182 EKIKKQIKILNQCLIEDFQISLPKIAVLGLNPHAGDGGVIGNEEIEIIQPAVKDVFDNGI 241

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
              G  PAD+ FQP      DAVLAMYHDQGL   K   +  GVN T GLP+IRTS DHG
Sbjct: 242 LAFGAFPADSFFQPSKYTKFDAVLAMYHDQGLAPFKTLAYEEGVNYTAGLPYIRTSPDHG 301

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNTQ 329
            A ++AG+  AD  SF  A+ +AIK+  N Q
Sbjct: 302 VAYDIAGQNLADEQSFSEAIFMAIKIFKNRQ 332


>UniRef50_B4S6L0 4-hydroxythreonine-4-phosphate dehydrogenase n=12 Tax=Chlorobiaceae
           RepID=PDXA_PROA2
          Length = 338

 Score =  378 bits (971), Expect = e-103,   Method: Composition-based stats.
 Identities = 114/333 (34%), Positives = 169/333 (50%), Gaps = 10/333 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPV------ELVVCADATLLTNRAAMLGLPLTLRP 58
           +    T G+  GIGP+++++              + +V   A  L   +  LGL + +R 
Sbjct: 2   KTTAWTIGDIHGIGPEIILKTFDESLRSTGQPEEKPIVIGSAEALLYYSKRLGLSIDIRT 61

Query: 59  YSPNSPAQPQTAGTLTLLPVALRA-PVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                 A     G L ++ V   + P+  G ++ E G   +  + +A + CL G  AA++
Sbjct: 62  IDAPEKAAAYPQGVLPVISVGEPSSPLQPGTISAEAGRLSMLAIEKAANLCLEGRCAAMV 121

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATE--ELRVALATTHLPLRDIADA 175
           T P+HK  +  AG P TGHT+F  +        M+       L VALAT H+ L  + + 
Sbjct: 122 TAPIHKEAVARAGYPHTGHTDFLADLCATDNPTMLFRDPVSGLMVALATIHVALHRVPEL 181

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           I    +    + L+  L++ F I +PRI V GLNPHA +GG MG EE + I+P ++ L A
Sbjct: 182 IRSMDMSAFFSNLNRSLQSDFRIEQPRIAVLGLNPHASDGGVMGREEKEIILPCIDAL-A 240

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
               + GP  AD  F      N D  +AMYHDQGL   K   F  G+N+TLGLP +RTS 
Sbjct: 241 DRQNIEGPFAADGFFGSGKYRNYDVTVAMYHDQGLLPFKVLAFDTGINVTLGLPLVRTSP 300

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           DHGT+ ++AG+G+A   SF  A  LA ++  N 
Sbjct: 301 DHGTSFDIAGQGRASHRSFSEAAKLAWEIAFNR 333


>UniRef50_Q0FGB3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Rhodobacterales RepID=Q0FGB3_9RHOB
          Length = 325

 Score =  377 bits (969), Expect = e-103,   Method: Composition-based stats.
 Identities = 124/327 (37%), Positives = 167/327 (51%), Gaps = 6/327 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
              V +T G+P GIG D+  +  +  +  +   + AD   L  RA          P    
Sbjct: 2   NLPVALTCGDPNGIGIDISFEAKKELKNRIPFFLIADINHLKKRAHAQSFVKIQHPKECF 61

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
           + ++      L +L        T       N     E + RA D   N E  A+ T P++
Sbjct: 62  NISKD----ILPVLHHEFPETPTLNGSQPGNALATTEVIERAVDLFQNHEIHAICTNPIN 117

Query: 123 KGVINDA-GIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           K V+ +  G  + GHTE+    +  K  VMML  EELRV   T H+ L+D++  +T  LL
Sbjct: 118 KEVLKEGCGFEYPGHTEYLANLAGHKNSVMMLLCEELRVVPTTIHIALKDVSKLLTKELL 177

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
              I      L   FGI +PR+ + GLNPHAGE G  G EEI  I P + +LR+QG  + 
Sbjct: 178 INTINTTRDALINHFGIKKPRVAISGLNPHAGENGIFGQEEIKIINPTIEKLRSQGFDII 237

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GPL ADT+F  +  +N D  + MYHDQ L  +K   F  GVN+TLGLPFIRTS DHGTA 
Sbjct: 238 GPLSADTMFHKEARNNYDVAICMYHDQALIPIKTIDFYGGVNVTLGLPFIRTSPDHGTAF 297

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNT 328
           ELAG  KA+  S I+AL +A K+    
Sbjct: 298 ELAGTRKANPRSLISALEVAYKISNGK 324


>UniRef50_D0LQB4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Haliangium
           ochraceum DSM 14365 RepID=D0LQB4_HALO1
          Length = 338

 Score =  377 bits (969), Expect = e-103,   Method: Composition-based stats.
 Identities = 120/334 (35%), Positives = 165/334 (49%), Gaps = 19/334 (5%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNR-AAMLGLPLTL 56
           M  + ++ IT G+PAGIGP+++         E    L +  D  +L    A + G  +  
Sbjct: 1   MTTSDKIGITLGDPAGIGPEIIAAAVADASAELRGRLTLFGDRPILERAFAQITGSRIP- 59

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
                 S  Q    G L+            G     +G   V  L  A      G    L
Sbjct: 60  ------SDIQVVDRGLLS------ADQAIPGSPTGASGAAQVAYLEAAVSAARRGTIGGL 107

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
           +T P++K     AG  F GHTEF  ER  A+ V MM A   L+V LAT HL L ++  A+
Sbjct: 108 VTAPINKRSARQAGFSFPGHTEFLAERLGAQHVAMMFAGPRLKVVLATVHLALSEVPGAL 167

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           T   +     +    +   FGIA  R+ V GLNPHAGE G  G EE++ I P + E R Q
Sbjct: 168 TRDGIVRTAKLAAEAVSRDFGIASARVGVLGLNPHAGEHGLFGREELEIIGPAIEECRRQ 227

Query: 237 --GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
             G +++GPL  D  F+       D ++AMYHDQGL  +K   F + VN+TLGLP +RTS
Sbjct: 228 IDGAQVDGPLIPDAAFRQADGGAYDVLVAMYHDQGLIPVKLLDFEQAVNVTLGLPIVRTS 287

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
            DHG A ++AG GKA   SF+ AL+LA ++  + 
Sbjct: 288 PDHGVAYDIAGTGKARPQSFMAALSLAARLTTHR 321


>UniRef50_Q215S3 4-hydroxythreonine-4-phosphate dehydrogenase n=10
           Tax=Alphaproteobacteria RepID=Q215S3_RHOPB
          Length = 339

 Score =  376 bits (967), Expect = e-103,   Method: Composition-based stats.
 Identities = 128/334 (38%), Positives = 168/334 (50%), Gaps = 8/334 (2%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRP 58
           V  + + +T GEPAGIGPD+ +               +  D   L  RAA LGL +    
Sbjct: 4   VSNKPLALTLGEPAGIGPDVALAAWLGRGTSPIPAFYLLGDRAFLQARAATLGLNVPFAE 63

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
             P   A    A  L ++          G+    +    +  + +A    + G  AA++T
Sbjct: 64  VRP-DQAAATFADALPVVGTGHPVTAMPGRPDGSSAAAAIGAIRQAVQDVIAGRAAAVVT 122

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAK----KVVMMLATEELRVALATTHLPLRDIAD 174
            P+ K V+  AG    GHTEF  E ++ +    + VMML +E L V   T HLPLRD   
Sbjct: 123 NPIAKSVLYQAGFKHPGHTEFLAELARGEGAPPQPVMMLWSEALAVVPVTIHLPLRDAIA 182

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +T  L+     I+   LR    IA PR+ V GLNPHAGE G +G E+   I P +  LR
Sbjct: 183 QLTTGLIVSTARIVASALRRHMRIAAPRLAVSGLNPHAGEDGGLGREDQSIIAPAVEILR 242

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
             G+   GPLPADT+F        D  L MYHDQ L  +K   F R VN+TLGLPF+RTS
Sbjct: 243 RDGIDARGPLPADTMFHEAARKTYDCALCMYHDQALIPVKTLAFDRAVNVTLGLPFVRTS 302

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
            DHGTA ++AG G+AD  S I AL LA +M   T
Sbjct: 303 PDHGTAFDIAGSGRADPSSLIEALRLAARMATPT 336


>UniRef50_B1L710 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Korarchaeum cryptofilum OPF8 RepID=B1L710_KORCO
          Length = 316

 Score =  375 bits (964), Expect = e-102,   Method: Composition-based stats.
 Identities = 119/318 (37%), Positives = 176/318 (55%), Gaps = 8/318 (2%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           V++T G+P G+GP+++V+   +   + + V      L       GL +   P    +P +
Sbjct: 4   VIVTAGDPLGVGPEVLVKAI-KRLGLPVTVIGSIRSLKKACESCGLDMDFTPVDEPTPLR 62

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
                 + ++ +       +G    E G +    + +A +  L G+  AL+TGPV K  +
Sbjct: 63  DS----VPVIDIDDFGVEGSG-PTPEGGLHSYLCIRKASELILGGKAEALVTGPVSKEAV 117

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIA 186
           N AGI FTGHTE   E +  +K  MML  +ELRV+  TTH+ L+D+   +T   +   + 
Sbjct: 118 NMAGIKFTGHTELLAELAGGRKTKMMLFLDELRVSHVTTHVALKDVPRLLTEEEIIVTVE 177

Query: 187 ILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPA 246
           +    L  K G    +I V  LNPHAGEGG  G EEI  I P + +L  +G ++ GP+PA
Sbjct: 178 LTSSFL-GKLG-EPGKIGVSSLNPHAGEGGLFGDEEIRIIRPAIEKLIDRGYEVEGPIPA 235

Query: 247 DTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGR 306
           DT+F         AV+AMYHDQG   +K  GF R VN+TLGLP++RTSVDHGTA ++AG+
Sbjct: 236 DTIFLRAMRGEFKAVVAMYHDQGHIPIKLLGFNRAVNVTLGLPYVRTSVDHGTAYDIAGK 295

Query: 307 GKADVGSFITALNLAIKM 324
             AD GS + A+ LA ++
Sbjct: 296 CLADEGSMVNAIRLAFRL 313


>UniRef50_Q6AB12 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Actinomycetales RepID=PDXA_PROAC
          Length = 346

 Score =  375 bits (964), Expect = e-102,   Method: Composition-based stats.
 Identities = 109/331 (32%), Positives = 167/331 (50%), Gaps = 6/331 (1%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQ---REWPVELVVCADATLLTNRAAMLGLPLTLR 57
           M KT  + IT G+PAGIGP++ VQ       +     +V  D  +++   ++ GL  T+R
Sbjct: 1   MPKTPLLGITEGDPAGIGPEITVQAIHNMADDRSFIPIVYGDPAIISRACSVTGLSETVR 60

Query: 58  PYSPNSPAQPQT--AGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
             +     +P++     +    V     +  G +    G   + ++  A D  L+G+   
Sbjct: 61  RVTSEEHIEPESNVINVVDTGTVPHADSIEWGSVQELAGRAAIASIEAATDAALSGKTDG 120

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           ++T P++K  I   G  F GHTE             M     L++  AT H+ LR+  D+
Sbjct: 121 VVTSPINKEAIWKTGSEFLGHTEMLGSLCGTPDTDTMFVVSGLKIFFATRHMSLREAVDS 180

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           I   L+   I      L+  FG   P++ V  LNPHAGEGGH GTEEI+ + P +    A
Sbjct: 181 IRRDLIDHEIHKALRALKV-FGCNSPKLAVAALNPHAGEGGHFGTEEIEVLRPAVKSACA 239

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G  + GP+PAD++F    +   D VL++YHDQG    K   F   V++T GLP +RTSV
Sbjct: 240 EGHNVVGPVPADSVFHKGVIREYDGVLSLYHDQGHIASKTLDFDGTVSVTAGLPILRTSV 299

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIV 326
           DHGTA ++AG+G A   +  +AL++A     
Sbjct: 300 DHGTAFDIAGQGAASPMTMQSALHVASDFAR 330


>UniRef50_Q02C14 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Solibacter usitatus Ellin6076 RepID=Q02C14_SOLUE
          Length = 339

 Score =  375 bits (964), Expect = e-102,   Method: Composition-based stats.
 Identities = 114/317 (35%), Positives = 164/317 (51%), Gaps = 19/317 (5%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPY 59
               + +T G+PAGIGP++V+Q         L   +V  D  +L   + + G+ L  + +
Sbjct: 8   NRPVIALTMGDPAGIGPEIVLQAVADPDLAPLARWIVVGDGEVLEQASRITGIGLQAKLH 67

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
              + A                     G+L    G   VE +  A + CL GE  A++T 
Sbjct: 68  DARALADID--------------QFMFGRLDARCGIAAVEYVRIATEMCLAGEAEAIVTA 113

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P++K  +  +G PFTGHTE+  E   A +  M+L +E L     TTH+ LR   +  T A
Sbjct: 114 PLNKEAVTLSGRPFTGHTEYIAELCGATESRMLLCSERLSTIHVTTHVALRTACETGT-A 172

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +   I + +  ++   G +EPRI VCGLNPHAGE G  G E+   I+P +   RA+G+ 
Sbjct: 173 RILRTIELGNDAMK-LLGKSEPRIAVCGLNPHAGEHGLFGDEDQRVIVPAVEAARAKGIA 231

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
            +GP   DT+F        D V+AMYHDQG   +K   F   VNI+LG+P IRTSVDHGT
Sbjct: 232 CSGPHAPDTVFLQAVRGAYDLVVAMYHDQGHIPMKLIDFEGTVNISLGIPIIRTSVDHGT 291

Query: 300 ALELAGRGKADVGSFIT 316
           A ++AG+G+AD  S   
Sbjct: 292 AFDIAGKGRADARSIKQ 308


>UniRef50_A6H263 4-hydroxythreonine-4-phosphate dehydrogenase n=14 Tax=Bacteroidetes
           RepID=A6H263_FLAPJ
          Length = 349

 Score =  374 bits (961), Expect = e-102,   Method: Composition-based stats.
 Identities = 108/330 (32%), Positives = 168/330 (50%), Gaps = 8/330 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPY 59
           +   V I+ G+  GIG +++++  +    +EL   ++ A+  +L+     L L   L   
Sbjct: 6   ENIIVGISIGDLNGIGSEVILKSFEDSRMLELCTPIIFANVKILSFLKKELRLEAPLHGI 65

Query: 60  SPNSPAQPQTAGTLTLLPVALR-APVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                      G + +L V      +  GQL    G Y +++   A +    G    L+T
Sbjct: 66  DRLDQ---MVIGKINVLNVWREGVNINYGQLDNAVGKYAIKSFVAATNALKEGGIDVLVT 122

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P+ K  I      F GHT++ ++  +    +M +  + LRV L T H+PL ++A  +T 
Sbjct: 123 APISKANIQTEDFKFPGHTDYLDQELEG-DALMFMIQDNLRVGLLTDHVPLSEVAKHLTE 181

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
            L+ + I  ++  L   FGI +P+I V GLNPH+ + G +G EE   I P L ++  +G 
Sbjct: 182 ELIRKKIKTINKSLIQDFGIRKPKIAVLGLNPHSSDNGVIGNEEDKIIKPTLKKIFDEGT 241

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            + GP  AD  F     +N DAV+A YHDQGL   K   FG+GVN T GL  +RTS DHG
Sbjct: 242 LVFGPFSADGFFGNNQYENYDAVIATYHDQGLIPFKTLSFGKGVNYTAGLNKVRTSPDHG 301

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNT 328
           TA E+AG+G A+  SF+ A+  AI +  + 
Sbjct: 302 TAFEIAGKGIANNNSFLEAIYTAIDIFKSR 331


>UniRef50_C6XKP9 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Hirschia
           baltica ATCC 49814 RepID=C6XKP9_HIRBI
          Length = 339

 Score =  374 bits (961), Expect = e-102,   Method: Composition-based stats.
 Identities = 123/337 (36%), Positives = 176/337 (52%), Gaps = 10/337 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVE--LVVCADATLLTNRAAMLGLPLTLRP 58
           M     + +T G+PAG+GP L  +   +    +    V A + +L N   + G+   ++ 
Sbjct: 1   MSDNLPLAVTMGDPAGVGPILTWRAWHQRSTTQRPFFVIASSDILKNSQELSGVDGNIQI 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
               + A+     +L +L +        GQ   E+   ++ ++ +A +     + A ++T
Sbjct: 61  IQTPADAEKAFHTSLPVLEIECP-DTKTGQPNPESAAAIIASIEKAVEFTFENKAAGVVT 119

Query: 119 GPVHKGVINDAGIPFTGHTEFFEER-------SQAKKVVMMLATEELRVALATTHLPLRD 171
            P++K ++   G  F GHTEF  E        S+A   +MML    LRVALAT H PLR 
Sbjct: 120 NPINKALLYKKGFKFPGHTEFLAELARQHTHMSKAPLPIMMLVGGGLRVALATIHEPLRK 179

Query: 172 IADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLN 231
           + D +T +L+ EV  I+H  L   FG + P I + GLNPHAGE G +G EEI+ I P   
Sbjct: 180 VPDLLTQSLIEEVSNIVHAGLVRNFGFSSPTIALAGLNPHAGEEGSLGMEEIEQINPAAA 239

Query: 232 ELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFI 291
            LR +G++++   P DT+F        DAV+AMYHDQGL  LK      GVN+TLGLPFI
Sbjct: 240 ALRQRGLQISDAQPGDTVFHAMLEGQFDAVIAMYHDQGLAPLKSLDMWGGVNVTLGLPFI 299

Query: 292 RTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           RTS DHGT   +A  G A   S I A+NLA  M    
Sbjct: 300 RTSPDHGTGYGVAADGSARPDSLIAAINLASDMAKAR 336


>UniRef50_A0LA33 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Magnetococcus
           sp. MC-1 RepID=A0LA33_MAGSM
          Length = 346

 Score =  373 bits (958), Expect = e-102,   Method: Composition-based stats.
 Identities = 120/336 (35%), Positives = 179/336 (53%), Gaps = 13/336 (3%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWP--------VELVVCADATLLTNRAAMLGL-PLTL 56
            + +T G+PAGIGP++V++   ++           + +   D  +L   A  +GL P  L
Sbjct: 5   PIALTMGDPAGIGPEIVLKAFAQQQRERQKRLAGAKWLWVGDPEVLLWTAQQMGLVPPKL 64

Query: 57  RPYSPNSPAQPQTAGTLTLLPVA---LRAPVTAGQLAVENGHYVVETLARACDGCLNGEF 113
           +     +         L +LP+     R  +  G     +   VVE++  A    ++G+ 
Sbjct: 65  QRVRQAAEVAQVADEVLAVLPLEACIDRHKLAFGVADGAHAKAVVESIETATALAMSGQV 124

Query: 114 AALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIA 173
             ++T P+HKGV++  G  + GHTE     +     VMMLA   LRV  AT H  +R + 
Sbjct: 125 GGVVTPPIHKGVLHAGGYRWPGHTELLGHCTGVTTPVMMLAGRGLRVVPATIHQSIRSVP 184

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL 233
           D+++ A L ++ +++ H L+  FG+ EPRI +C LNPHAGEGG  G EE   I P +  L
Sbjct: 185 DSLSVAKLTQIFSVVGHSLQQDFGLREPRIAICALNPHAGEGGAFGDEERRIIQPAMAAL 244

Query: 234 RAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
             + ++L GP PAD LF         A++ MYHDQ L  +K   FG   NITLGLP IRT
Sbjct: 245 MGE-VRLEGPFPADALFSEAARAPYGAIICMYHDQALIPIKMHCFGEATNITLGLPIIRT 303

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           SVDHGTA ++AG G+A  G+ + A+  A +M  N +
Sbjct: 304 SVDHGTAYDIAGSGRAKHGALLIAVEQAARMAANRR 339


>UniRef50_Q7UMZ2 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Rhodopirellula
           baltica RepID=PDXA_RHOBA
          Length = 351

 Score =  372 bits (956), Expect = e-102,   Method: Composition-based stats.
 Identities = 115/342 (33%), Positives = 164/342 (47%), Gaps = 24/342 (7%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLP-------- 53
            ++ IT G+ AGIGP++ +++            ++  DA +    A  LG          
Sbjct: 9   PKLAITMGDAAGIGPEISLRVWDSPEVQSQGYPLLFGDAAIYHRAAKKLGCDCPGTISLA 68

Query: 54  --LTLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNG 111
             L +   S  S A          L        T G+ +   G    +++  A D  ++G
Sbjct: 69  EFLDMPKQSIPSDAPHGVIVDCGKLTTEELGSFTPGKFSAATGRASYQSVTDAIDAAVSG 128

Query: 112 EFAALITGPVHKGVINDAGIPFTGHTEFFEERSQ------AKKVVMMLATEELRVALATT 165
              A++TGP+ K   + AGI F GHTE   +R+          V MMLA++ +   L T 
Sbjct: 129 HVDAIVTGPIQKEAWHQAGIDFPGHTELLADRAGRAVQGEPADVRMMLASDTIACVLETI 188

Query: 166 HLPLRDIADAITPALLHEVIAILHHDLRTKF----GIAEPRILVCGLNPHAGEGGHMGT- 220
           H+PL D+A  +    L   I +    ++ +      +  PRI VCGLNPHAGE G     
Sbjct: 189 HIPLADVASQLNTESLVRTINLAGETVQRRNQNRGSLLPPRIAVCGLNPHAGENGLFSHQ 248

Query: 221 EEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGR 280
           EE   I+P +   R  G  + GPL  DT F P   +  D  + MYHDQGL  LK   F  
Sbjct: 249 EEEQIILPAIEAARQSGWTIEGPLSPDTAFTPAMRERIDIYVCMYHDQGLIPLKALSFDD 308

Query: 281 GVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAI 322
            VN+TLGLP IRTSVDHGTA++LA +GKA + S + A+  A+
Sbjct: 309 AVNVTLGLPIIRTSVDHGTAMDLAWQGKASINSMLAAIRWAV 350


>UniRef50_C0CYU8 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CYU8_9CLOT
          Length = 331

 Score =  371 bits (954), Expect = e-101,   Method: Composition-based stats.
 Identities = 104/325 (32%), Positives = 167/325 (51%), Gaps = 7/325 (2%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
              ++I  G+PAGIGP++  +   RE        VV  D  ++     ++ LPLT+   +
Sbjct: 2   KPIILIPMGDPAGIGPEIAAKALAREETLQRARCVVVGDRQVMEQAVRIVDLPLTIHTIN 61

Query: 61  PNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                + +    + L+ +A         G+++   G    E +A +      G+ AA+ T
Sbjct: 62  EPEEGRFEE-RVINLIDLANVDMGQFKRGEISAMCGRAAYEYIATSISLANAGKAAAVST 120

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P++K  +  AG+P+ GHTE F   +     + M     +RV   T H+ LR   D IT 
Sbjct: 121 TPINKESLRAAGVPYIGHTEIFGALTGTPDPLTMFEVRNMRVFFLTRHVSLRKACDMITK 180

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + + +      L+   G+ +  + + GLNPH+GE G  G EE++ I P + EL+AQG 
Sbjct: 181 ERVIDYVKRCTQALKQ-LGVEDGTMAIAGLNPHSGEHGLFGDEEMEAIYPAVEELQAQGY 239

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           K+ GP+ AD++F        ++VL++YHDQG    K   F R + +T G+P +RTSVDHG
Sbjct: 240 KVAGPVGADSVFHMALQGKFNSVLSLYHDQGHIATKTLDFERTIAVTAGMPILRTSVDHG 299

Query: 299 TALELAGRGKADVGSFITALNLAIK 323
           TA+++AG G A   S + A+ LA K
Sbjct: 300 TAMDIAGTGIASDVSMVEAIRLAAK 324


>UniRef50_Q4JN67 Predicted 4-hydroxythreonine-4-phosphate dehydrogenase
           (4-(Phosphohydroxy)-L-threonine dehydrogenase) n=1
           Tax=uncultured bacterium BAC13K9BAC RepID=Q4JN67_9BACT
          Length = 326

 Score =  371 bits (954), Expect = e-101,   Method: Composition-based stats.
 Identities = 128/324 (39%), Positives = 191/324 (58%), Gaps = 1/324 (0%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + ++ IT G+P GIGPD+ V +A++      ++  D  LL + +  L   + +      +
Sbjct: 2   SIKIAITVGDPGGIGPDICVLMAEKYLKKYHIIITDPQLLIDSSKKLNKKVFINILKNIN 61

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A       + +LP+ L      G +   N  +V+  +  A  GCLN  F +++TGP+ K
Sbjct: 62  DAPKSGKRLINVLPIKLNKKNKPGHMNPINAPFVINAIETAAKGCLNHNFQSMVTGPISK 121

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
            ++N  G   +GHTE   +  ++K  +MML  ++L+V L T H+PL  ++  IT   +  
Sbjct: 122 SILNRGGFKISGHTELLAKICKSKS-IMMLMNDKLKVTLQTIHVPLNKVSKQITEKNIIG 180

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            I I++HDL  KFG+  P+IL+CGLNPHAGE G +G EEI+ I P +  L+  G+ ++GP
Sbjct: 181 KIKIINHDLINKFGLKNPKILICGLNPHAGEEGILGNEEINIIKPAILSLKKLGINVDGP 240

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           +PADT F  KY++  D +  MYHDQGLPV+KY  F +  N+TLGLP IR SVDHGTA EL
Sbjct: 241 VPADTAFISKYINEYDVIHTMYHDQGLPVIKYDNFSKTTNVTLGLPIIRVSVDHGTATEL 300

Query: 304 AGRGKADVGSFITALNLAIKMIVN 327
            G G  D+ SFI AL +A  +  +
Sbjct: 301 VGTGNVDISSFIQALKVARDISKS 324


>UniRef50_B1IGV8 4-hydroxythreonine-4-phosphate dehydrogenase n=39 Tax=Bacteria
           RepID=PDXA_CLOBK
          Length = 334

 Score =  370 bits (950), Expect = e-101,   Method: Composition-based stats.
 Identities = 96/329 (29%), Positives = 165/329 (50%), Gaps = 8/329 (2%)

Query: 1   MVKTQRVV-ITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTL 56
           M+  + ++ I  G+PAG+GP++VV+        E    ++  DA ++        + L +
Sbjct: 1   MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNI 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFA 114
                    +  T GT+ L+ +       +  G++    G    E + ++ +    GE  
Sbjct: 61  NSIKKADEGKF-TLGTIDLIDLNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELD 119

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
           A+ T P++K  + +  + + GHTE   + +  +  + M     +RV   T H+ LR   D
Sbjct: 120 AIATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEVRGMRVFFLTRHVSLRKACD 179

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +T   + + I      L  K G+ + ++ V GLNPH+GE G  G EE+  ++P + E +
Sbjct: 180 LVTKERVLDYIIRCSEAL-EKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQ 238

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
             G K+ GP+ AD++F        ++VL++YHDQG    K   F R + +T G+P +RTS
Sbjct: 239 KMGYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTS 298

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIK 323
           VDHGTA ++AG G+A   S + A+ LA K
Sbjct: 299 VDHGTAFDIAGTGQASSVSMVEAIVLAAK 327


>UniRef50_Q2N8X0 4-hydroxythreonine-4-phosphate dehydrogenase n=5
           Tax=Sphingomonadales RepID=PDXA_ERYLH
          Length = 336

 Score =  368 bits (946), Expect = e-100,   Method: Composition-based stats.
 Identities = 117/334 (35%), Positives = 164/334 (49%), Gaps = 7/334 (2%)

Query: 1   MVKTQR-VVITPGEPAGIGPDLVVQLAQREWPV---ELVVCADATLLTNRAAMLGLPLTL 56
           M + QR + ++ G+PAGIGP+++V   +           V   A +L +    LG+P  +
Sbjct: 1   MGEPQRPLAVSLGDPAGIGPEIIVHAWRMRDSANLAPFAVAGGANVLRSATEALGVPCPI 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
           +     + A       L ++   L      G          +++L  A      G  + +
Sbjct: 61  QEIDDIAEANSAFLEALPVIK-GLDGAYLPGAPDPIGAKLALKSLEMATRLATAGHASGV 119

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKK--VVMMLATEELRVALATTHLPLRDIAD 174
           +T P+ KG++   G    G TEF        +   VMMLA   LR    T H PL ++  
Sbjct: 120 VTAPIAKGLLEQVGFTHPGQTEFLAAACGLPEDASVMMLAGPSLRAVPLTVHCPLAEVPG 179

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            ++  L+ E   I+   L+  FGI  PR+ V GLNPHAGE G  G EE D I P + EL 
Sbjct: 180 LLSIGLIVERGRIVASALQRDFGIERPRLAVTGLNPHAGEDGKFGNEEQDVIAPAIAELL 239

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           A G+   GP PAD LF P      DA L MYHDQ L  +K   F +GVN+TLGLP +RTS
Sbjct: 240 ADGITATGPHPADALFSPHSRAGFDAALCMYHDQALIPVKALDFDQGVNVTLGLPIVRTS 299

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
            DHGTA ++AGRG A  G+ + AL +A +     
Sbjct: 300 PDHGTAFDIAGRGTAHPGAMVFALLMAGECAARR 333


>UniRef50_D2R6V9 4-hydroxythreonine-4-phosphate dehydrogenase n=7 Tax=Bacteria
           RepID=D2R6V9_9PLAN
          Length = 344

 Score =  368 bits (945), Expect = e-100,   Method: Composition-based stats.
 Identities = 121/333 (36%), Positives = 180/333 (54%), Gaps = 8/333 (2%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRP 58
           + ++RV IT G+ AG+GP++ ++L      V     +V  DA +LT  +A  G+      
Sbjct: 12  MPSKRVAITMGDAAGVGPEICLRLLADPQIVRECIPIVIGDAEVLTRVSAATGISWQADV 71

Query: 59  YSPNSPAQPQTAG---TLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
            S     +  +A    T+  LP    A V  G ++   G    E ++ A D  +  +  A
Sbjct: 72  ISLGEWNRAPSAIVRPTVVHLPSLDAASVVPGSISAMTGRASYEYISAAIDAVIAQDVCA 131

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           + TGP+ K  ++ AG+ F GHTE F  R+ +++  MM  +E +     T H+   ++ + 
Sbjct: 132 VTTGPISKEALHAAGLKFPGHTEIFASRTSSQRSCMMQYSEIITCTFVTVHVGYYEVPEL 191

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMG-TEEIDTIIPVLNELR 234
           +T   + +VI +    L    G A P+++VCGLNPHAGE G  G  EE   IIP +   R
Sbjct: 192 LTTERIGDVIDLTADALLKIRGRA-PKMVVCGLNPHAGEHGLFGNREEERVIIPAIAAAR 250

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           A+G +++GPLP DT F P      DA + MYHDQG   +K   F + VN TLGLP IRTS
Sbjct: 251 ARGHQIDGPLPPDTCFTPAKRAITDAFICMYHDQGHIPVKALAFEQAVNTTLGLPVIRTS 310

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           VDHGTA ++A +GKAD  S   A+ LA+++  N
Sbjct: 311 VDHGTACDIAWQGKADPSSLFAAVRLAVRLADN 343


>UniRef50_Q475Q2 4-hydroxythreonine-4-phosphate dehydrogenase n=261
           Tax=Proteobacteria RepID=PDXA_RALEJ
          Length = 347

 Score =  367 bits (942), Expect = e-100,   Method: Composition-based stats.
 Identities = 176/343 (51%), Positives = 214/343 (62%), Gaps = 24/343 (6%)

Query: 1   MVKTQRVVITPGEPAGIGPDLV----VQLAQREWPVELVVCADATLLTNRAAMLGLPLTL 56
           M     + I+ GEPAGIGPD+     +QLA +       V  DA LL +RAA LG+    
Sbjct: 1   MPDPLALAISTGEPAGIGPDITIGALLQLAGQNGHARYHVLGDAHLLASRAAALGVA--- 57

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNG----- 111
                ++  +    G + +  V L      G+L   NG YV+  L  A  GC        
Sbjct: 58  -----HAWERRIAEGEVVIHHVPLAVACEPGRLDARNGPYVLSMLDAAIAGCRTHAGAPA 112

Query: 112 EFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE-------LRVALAT 164
            FAA++T PV K  INDAG+PFTGHTE+  E +   +VVMMLA  +       LRVALAT
Sbjct: 113 RFAAMVTAPVQKSTINDAGVPFTGHTEYLAEAAGVPRVVMMLAGPQPAHANAMLRVALAT 172

Query: 165 THLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEID 224
           THLPLR +ADA+T  LL E ++I+  DLR  FGIA PRILV GLNPHAGE GHMG EEI+
Sbjct: 173 THLPLRAVADAVTVPLLLETLSIIDADLRRWFGIARPRILVTGLNPHAGESGHMGREEIN 232

Query: 225 TIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNI 284
            I P L + R  G+   GP PADTLFQP++L +AD VLAMYHDQGL  LKY  FG GVNI
Sbjct: 233 VIEPALAQARDAGIDARGPYPADTLFQPRHLRDADCVLAMYHDQGLAPLKYGTFGHGVNI 292

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           TLGLPFIRTSVDHGTAL+LAG G+A+ GS I A+  A+ M  +
Sbjct: 293 TLGLPFIRTSVDHGTALDLAGSGQAEHGSMIEAIRSAVTMAGH 335


>UniRef50_D0J9Z1 4-hydroxythreonin-phosphate dehydrogenase n=1 Tax=Blattabacterium
           sp. (Periplaneta americana) str. BPLAN
           RepID=D0J9Z1_BLASP
          Length = 363

 Score =  365 bits (937), Expect = 2e-99,   Method: Composition-based stats.
 Identities = 105/332 (31%), Positives = 173/332 (52%), Gaps = 8/332 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLT-LRP 58
           K  +V ++ G+  GIG ++ +++ +++  ++    ++     L +    +L + +  +R 
Sbjct: 27  KKIKVGVSTGDINGIGIEIFLKVCRKKKLLDFFTPILFGSIKLCSYYKKILNIEVNNMRE 86

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                         L +    ++  +   ++  ++G Y + +L +A      G+   L+T
Sbjct: 87  IKNLKDIVDYKINVLNIWKEDIKFDLI--KINQDSGKYPILSLKKATKALKEGKIDVLVT 144

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            PV+K  +N     F GHTE+ +   +  + +M++  + L++AL T HLPL+++   IT 
Sbjct: 145 APVNKNWMNHKEFSFFGHTEYLQNILEG-ESLMLMIHDTLKIALVTNHLPLKNVTHEITT 203

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL-RAQG 237
             + + I ILH  L   F I +P+I V G NPH+GE G +G EE   I P ++ L + QG
Sbjct: 204 KKIIKSIKILHKSLIMDFSIEKPKIAVLGCNPHSGENGLIGDEEKTKIKPAIDSLFQKQG 263

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
             + GP   D  F  ++  N DAVLAMYHDQGL   K   F  GVN T GL  IRTS DH
Sbjct: 264 FLVFGPYSPDGFFGNQHYRNFDAVLAMYHDQGLIPFKTLTFNEGVNFTAGLSHIRTSPDH 323

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           G A ++A +G A+  SF  A+  AIK+  N +
Sbjct: 324 GVAYDIAKKGIANENSFEEAIFSAIKIFKNRK 355


>UniRef50_Q92X16 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=18
           Tax=Alphaproteobacteria RepID=PDXA2_RHIME
          Length = 321

 Score =  364 bits (936), Expect = 2e-99,   Method: Composition-based stats.
 Identities = 102/328 (31%), Positives = 161/328 (49%), Gaps = 18/328 (5%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYS 60
           ++ + IT G+P G+GP++ V+        +     +  +   L      LGL + L+PY 
Sbjct: 2   SKIIGITMGDPCGVGPEITVRSLAEMSAADREATRIYGNLATLEAAREALGLSVDLQPYV 61

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            +   +               AP+  G L+   G      + RA      G    ++T P
Sbjct: 62  VDLTVE--------------GAPLPWGSLSAVAGDAAFRFIERAVRDAEAGNIGCIVTAP 107

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           ++K  +N AG  + GHT      + +    M+LA+E L+V   +TH+ L++     T   
Sbjct: 108 INKEALNMAGHHYDGHTGMLRSLTGSSAAYMLLASERLKVIHVSTHVSLKEAIGRATTER 167

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +   I   +  L+ + G   PRI V G+NPH GE G  GTE+ D I P +   R +G+ +
Sbjct: 168 VLATIRAGNAHLK-RIGYEHPRIAVAGINPHCGENGLFGTEDDDQIGPAVAAAREEGIDV 226

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+ ADT+F   Y    D V+A YHDQG   +K   F   VN+++ LP  RTSVDHGTA
Sbjct: 227 QGPISADTVFHRAYSGGFDLVVAQYHDQGHIPIKLVAFDTAVNVSVDLPIDRTSVDHGTA 286

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNT 328
            ++AG+G A+ G+  +A+  A K++   
Sbjct: 287 FDIAGKGIANHGNLNSAIAYARKLVAGQ 314


>UniRef50_Q0EWH4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Mariprofundus
           ferrooxydans PV-1 RepID=Q0EWH4_9PROT
          Length = 340

 Score =  364 bits (935), Expect = 2e-99,   Method: Composition-based stats.
 Identities = 130/335 (38%), Positives = 183/335 (54%), Gaps = 14/335 (4%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           + ++IT GEPAGIG D +++  Q   +   + ++ A A  L  RA ++G+ + ++  +  
Sbjct: 2   KPLLITAGEPAGIGTDCILRAWQHTPQLFKQCIIAAPALWLRERADLIGIDVIIKESADL 61

Query: 63  SPAQPQTAGTLTLLPVALR----APVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                     L             PVT GQ +      V+  +  A   CL+   AALIT
Sbjct: 62  QQIDCSDTSRLHCWNPLAANVAVDPVTPGQPSPGTARAVITCIESAALACLDNRAAALIT 121

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAK--------KVVMMLATEELRVALATTHLPLR 170
           GP+ K V+ ++G  F GHTEF    S++           VMMLA+++LRVAL TTH+ + 
Sbjct: 122 GPIEKAVLRESGFTFPGHTEFLAHLSRSNASLATDHMDHVMMLASDQLRVALLTTHIAIS 181

Query: 171 DIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVL 230
           D+  +++     + + I+ HDLR +F I +P I +CGLNPHAGE GH G EEID + P  
Sbjct: 182 DVPASLSIDGTLDGLRIVEHDLRKRFAIEKPHIGLCGLNPHAGEQGHFGREEIDILTPAA 241

Query: 231 NELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPF 290
              + +G+ + GPLPADTLF        DA++  YHDQ L  LK   FG  VNITLGLPF
Sbjct: 242 ELAKKRGIHVTGPLPADTLFSASQRSRFDAIVCCYHDQALIPLKALSFGDAVNITLGLPF 301

Query: 291 IRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
           IRTSVDHGTAL+  G       S + A+ +A  M 
Sbjct: 302 IRTSVDHGTALDRVGSQSVSYTSMVAAIRMASTMT 336


>UniRef50_C6C747 4-hydroxythreonine-4-phosphate dehydrogenase n=17 Tax=Bacteria
           RepID=C6C747_DICDC
          Length = 341

 Score =  364 bits (934), Expect = 3e-99,   Method: Composition-based stats.
 Identities = 101/326 (30%), Positives = 160/326 (49%), Gaps = 7/326 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPY 59
               V +T G+PAGIGP++ V     +   E     +     ++    A+      +   
Sbjct: 11  NKPVVALTIGDPAGIGPEISVATMMNQAVYEECRPFLIGSVPIIQRAMAIWNCDFAINVI 70

Query: 60  SPNSPAQPQTAGTLTLLPVAL--RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
              + A+    GTL +L         +  G++    G   ++ + ++    + GE   + 
Sbjct: 71  HSPAEARFTW-GTLDVLETGDYDCDSIVWGKVQKLAGQMSLDYVMKSIALGMAGEIDVVS 129

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           T P+HK  I  AG    GHTE ++  + +   + M   ++LRV   + H+ L+D  D   
Sbjct: 130 TAPIHKEAIKLAGCKLPGHTEIYQVETGSDYGLTMFHVQKLRVFFVSRHMALKDACDYAN 189

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              +   +  +HH+      I +PRI V  LNPHA + G  G EE D +IP +   +A G
Sbjct: 190 KERVLACVQQIHHEFTA-LNIPQPRIAVAALNPHASDNGLFGHEEKDNLIPAVQAAQALG 248

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           +   GP+PAD++F    L + DA+L++YHDQG    K   F R V IT GLPF+R+SVDH
Sbjct: 249 INAIGPVPADSVFHQGKLGHYDAILSLYHDQGHIACKTLDFERSVTITFGLPFMRSSVDH 308

Query: 298 GTALELAGRGKADVGSFITALNLAIK 323
           GTA ++AG GKA   S + +  +A +
Sbjct: 309 GTAFDIAGTGKAGTVSMLESTLVAAR 334


>UniRef50_A6C4H6 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Planctomyces
           maris DSM 8797 RepID=A6C4H6_9PLAN
          Length = 344

 Score =  364 bits (934), Expect = 3e-99,   Method: Composition-based stats.
 Identities = 111/342 (32%), Positives = 156/342 (45%), Gaps = 16/342 (4%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +K   + +T G+ +GIGP L+  L            VV  +A +L   +   G  L +R 
Sbjct: 1   MKLPLIALTMGDVSGIGPQLLDVLCSGSEIFQICRPVVYGNAAVLRRASQQSGSQLQIRE 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALR--APVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
               S +     G    +       A V   Q+   +G    + L  A D CL+GE  A+
Sbjct: 61  IESISDSLEFRVGIANCIDRGNSNVAEVVPCQIDARSGQGAYDYLVSAIDDCLSGEMDAI 120

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATE---------ELRVALATTHL 167
            T P++K  +  AGI + GHTE   +R       MML             L +   T H 
Sbjct: 121 TTAPLNKESLRLAGIDYPGHTEILADRCGVADYGMMLYLPHGAAIQSPAGLGIVHTTLHT 180

Query: 168 PLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTII 227
            +  +   ++   + E I ++   L  K G+A PR+ VC LNPHAGE G  G EE   I 
Sbjct: 181 SIASVPGLLSTDAIFEKIRLIS-GLMQKMGVAHPRVAVCALNPHAGEHGLFGDEEARIIS 239

Query: 228 PVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLG 287
           P + +    G+   GPLPADTL +       DAV+AMYHDQG    K  GF + VNITLG
Sbjct: 240 PAVEQAIQSGLDATGPLPADTLIRRAVRGEFDAVVAMYHDQGHIPFKLLGFDQAVNITLG 299

Query: 288 LPFIRTSVDHGTALELAGRGKA-DVGSFITALNLAIKMIVNT 328
           LP +RTS  HGTA ++A      +    I A   A ++  + 
Sbjct: 300 LPIVRTSPSHGTAFDIAWSDTVPETRGIIEATKAAARLSQHQ 341


>UniRef50_Q5NMX3 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Zymomonas
           mobilis RepID=PDXA_ZYMMO
          Length = 335

 Score =  364 bits (934), Expect = 4e-99,   Method: Composition-based stats.
 Identities = 115/330 (34%), Positives = 165/330 (50%), Gaps = 10/330 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSP 61
           + + +T G+P+GIGP++V +   R    +         A  +   +++      +   + 
Sbjct: 2   KPLAVTLGDPSGIGPEIVAKAWSRRKSDQIMPFFAIGSAASIQAVSSI-----PVVAITD 56

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            + A       L +  +  +  +T G+            L +       G+ +AL+T PV
Sbjct: 57  PNEAISIFDQALPVWDIPSKETITPGKPNKAGAEVAFAALEKGVALVKQGQASALVTAPV 116

Query: 122 HKGVINDAGIPFTGHTEFFEERSQ--AKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
            K  +   G  F G TEF   R    A   VMMLA  +LR    T H+P RD+ + +TP 
Sbjct: 117 SKAELYQVGFTFPGQTEFVANRCGIAADDAVMMLAGPDLRTVPLTIHIPYRDVLEQLTPK 176

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
           L+     +   DL+  F I  PR++V GLNPHAGE G +G EEID+I P + +L+A+ + 
Sbjct: 177 LIISRARVTVEDLKRNFAIPSPRLVVAGLNPHAGENGTIGREEIDSIEPAIRQLQAENID 236

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           + GP  ADTLF P+     D  L   HDQ L  +K   F  GVN TLGLP IRTS DHGT
Sbjct: 237 IKGPFAADTLFSPRARATYDVALCPTHDQALIPIKTINFDNGVNTTLGLPIIRTSPDHGT 296

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           A  LAG+ KAD G+ + AL +A     N Q
Sbjct: 297 AFPLAGKNKADEGAMVAALVMAANSAHNRQ 326


>UniRef50_P58711 4-hydroxythreonine-4-phosphate dehydrogenase n=64 Tax=root
           RepID=PDXA_ANASP
          Length = 362

 Score =  362 bits (930), Expect = 1e-98,   Method: Composition-based stats.
 Identities = 113/344 (32%), Positives = 170/344 (49%), Gaps = 24/344 (6%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
            R+ +T G+P GIG +++++           +L V ++  LL      L     L P + 
Sbjct: 18  PRLALTVGDPGGIGAEVILKALADLEIGHNYDLTVVSNKNLLQETYKQLSSMENLLPLAD 77

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            +  +         +       +  G     +G      +  A    L G F  ++TGP+
Sbjct: 78  PNLLKIIDV----TVDRETARQINLGTGNAASGAASFAYMDYAIAQTLAGNFDGIVTGPI 133

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLA------TEELRVALATTHLPLRDIADA 175
            K     AG  + G TE   ++S  ++  M+           LR  LATTH+PLR +AD 
Sbjct: 134 AKSAWKAAGYNYPGQTELLAQKSGVERFGMLFVARSPYTGWTLRALLATTHIPLRQVADT 193

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           +TP LL + + +L   L   FGI   RI + GLNPH+GE G +GTEE+D +IP L   R 
Sbjct: 194 LTPQLLTQKLDLLVECLEKDFGITSGRIAIAGLNPHSGEQGQLGTEELDWLIPWLESERQ 253

Query: 236 Q--GMKLNGPLPADTLFQPKYLDNA---------DAVLAMYHDQGLPVLKYQGFGRGVNI 284
           +    +L+GP+P DT++                 DA LA+YHDQGL  +K   F R VN 
Sbjct: 254 KRPHFQLDGPIPPDTMWVKPGQAWYGNAIVQHPADAYLALYHDQGLIPVKLMAFDRAVNT 313

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           ++GLPF+RTS DHGTA ++AG+G AD  S   A++LA +++   
Sbjct: 314 SIGLPFVRTSPDHGTAFDIAGQGIADATSMKEAISLAAELVCQR 357


>UniRef50_A5WDW5 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Gammaproteobacteria RepID=A5WDW5_PSYWF
          Length = 374

 Score =  360 bits (926), Expect = 3e-98,   Method: Composition-based stats.
 Identities = 170/358 (47%), Positives = 215/358 (60%), Gaps = 31/358 (8%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR----EWPVELVVCADATLLTNR--------AAM 49
             +  +V+T GEPAGIG D+++QLA +    E    L+V AD   L  R         + 
Sbjct: 17  PSSASLVVTTGEPAGIGMDILLQLAMQQKLGELSYPLIVLADEAALQQRFELIYGSGVSK 76

Query: 50  LGLPLTLRPYSPNSPAQPQTAGT------LTLLPVALRAPVTAGQLAVENGHYVVETLAR 103
           L  PL  R  S N   Q              LL V    PV AGQL V N   VV+ L  
Sbjct: 77  LSGPLWQRIESVNDLQQISGQTKGNALPQFYLLHVGCAEPVVAGQLNVNNAAMVVQQLQI 136

Query: 104 ACDGCLNGEFAALITGPVHKGVINDAGIP------FTGHTEFFEERSQAKKVVMMLATEE 157
           A     +G  +A++TGP+ K V+ DAGI       FTGHTEFF ++S  +KVVMMLA   
Sbjct: 137 AHQWAASGAASAIVTGPLQKSVLIDAGITLEDGGMFTGHTEFFMQKSGCQKVVMMLANSA 196

Query: 158 LRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGH 217
           ++VAL T H+PLR +ADAIT   + + + I+ +DLR KFG+  P+ILVCGLNPHAGE GH
Sbjct: 197 MKVALVTIHMPLRQVADAITADNVRQTVRIVLNDLRQKFGLPNPKILVCGLNPHAGEDGH 256

Query: 218 MGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQG 277
           +GTEEID I PVL E + QG  ++  +PADTLF  ++L + DAV+AMYHDQGLPVLK  G
Sbjct: 257 LGTEEIDIINPVLREFQQQGANISLAMPADTLFTTRHLQDCDAVIAMYHDQGLPVLKSHG 316

Query: 278 FGRGVNITLGLPFIRTSVDHGTALELAGRGKA------DVGSFITALNLAIKMIVNTQ 329
           FG  VN+TLGLP+IRTSVDHGTAL+LAG   A         S   AL +A  M+ + Q
Sbjct: 317 FGDTVNLTLGLPYIRTSVDHGTALDLAG-NSATSDVQPSSSSLWQALIMAEAMVHSQQ 373


>UniRef50_A0NP49 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Rhodobacteraceae RepID=A0NP49_9RHOB
          Length = 340

 Score =  360 bits (924), Expect = 5e-98,   Method: Composition-based stats.
 Identities = 108/335 (32%), Positives = 173/335 (51%), Gaps = 7/335 (2%)

Query: 1   MVKTQ-RVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTL 56
           M   + R+V+T G+PAGIG +LV +L   E   +   +++  D   L N   + G+    
Sbjct: 1   MTTPKPRLVLTLGDPAGIGSELVARLLADEEARQAAAILILGDEDELKNGMDIAGVRFEY 60

Query: 57  RPYSPNS-PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
              S  + P+Q     +   +  A        +++ E G + +ETL +  D   +G+  A
Sbjct: 61  EKVSEAALPSQATDVPSFFQVGTAPEGGWKRAEVSAEGGAHCLETLGKGVDLVRSGKADA 120

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAK-KVVMMLATEELRVALATTHLPLRDIAD 174
           L+  P++K  ++ AG+  +    +F +R      V  +   + L  +  T+H+ LRD+AD
Sbjct: 121 LVFAPLNKASLHSAGMSQSDELHWFADRLGHNGSVSELNVMDGLWTSRVTSHIALRDVAD 180

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            IT   + E   ++H  L+   G   PRI VCGLNPH G+ G+ GTEEI+ I P +   +
Sbjct: 181 LITEDKIIEAARLIHSALK-DAGFESPRIGVCGLNPHNGDNGNFGTEEIEIITPAVERAK 239

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           A G+ + GP P+DT+F        DA++ +YHDQG   +K  GF +GV +  GLP   T+
Sbjct: 240 ALGLPVEGPYPSDTIFLKAVAKELDAIVTLYHDQGQIAIKLLGFWQGVTVQGGLPIPITT 299

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
             HGTA ++ G+G A+VG    A N+A  M    +
Sbjct: 300 PAHGTAFDIRGKGTANVGPMRNAWNIACAMGTRRR 334


>UniRef50_A7IJ81 4-hydroxythreonine-4-phosphate dehydrogenase n=127
           Tax=Proteobacteria RepID=PDXA_XANP2
          Length = 350

 Score =  360 bits (924), Expect = 5e-98,   Method: Composition-based stats.
 Identities = 127/323 (39%), Positives = 173/323 (53%), Gaps = 9/323 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPV---ELVVCADATLLTNRAAMLGLPLTLR 57
           MV    +V++ G+PAGIGPD+ +    +   +     +V  D   L  R   LGL + L 
Sbjct: 1   MVAPAPLVLSLGDPAGIGPDITLTAWAQRRELGLPAFLVAGDPEALKARVRQLGLTVPLA 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
             +    A    A  L ++P    +    G     +   VV +L  A      G  AAL+
Sbjct: 61  E-TGPEDAAGHFAEALPVMPAGPASTALPGAPDASSAPCVVASLEAALGLVQAGRAAALV 119

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQ-----AKKVVMMLATEELRVALATTHLPLRDI 172
           T P+ K V+   G PF GHTEF   R+      A   VMM+ +E+L V  AT HLP  D+
Sbjct: 120 TNPLAKSVMYAGGFPFPGHTEFLAARAARPGRPAPHPVMMIWSEQLAVVPATIHLPYADV 179

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
              +T  LL E   I+  D+  +FG+A PR++ CGLNPHAGE G +GTE+   + P +  
Sbjct: 180 PGHLTIDLLVETGRIVAGDMARRFGLAHPRLVFCGLNPHAGEEGTLGTEDEAIVRPAVEA 239

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
           L+ +G+   GPLPADTLF P+     D  + MYHDQ L   K   F  GVN+TLGLPFIR
Sbjct: 240 LKREGIDARGPLPADTLFHPQARAGYDVAVGMYHDQVLIPAKTLAFHDGVNVTLGLPFIR 299

Query: 293 TSVDHGTALELAGRGKADVGSFI 315
           TS DHGTA ++AG G+A+  S +
Sbjct: 300 TSPDHGTAFDIAGTGRANPSSLV 322


>UniRef50_Q8DHB4 4-hydroxythreonine-4-phosphate dehydrogenase n=13 Tax=Cyanobacteria
           RepID=PDXA_THEEB
          Length = 341

 Score =  357 bits (917), Expect = 4e-97,   Method: Composition-based stats.
 Identities = 118/342 (34%), Positives = 169/342 (49%), Gaps = 30/342 (8%)

Query: 7   VVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + +T G+PAGIGP+++++       E   +  +     +L    A L      +      
Sbjct: 3   LALTLGDPAGIGPEILLKALAHLPSELLGQFFIAGTGQVLEETYARL----CQQGQVAID 58

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
           PAQ      L L    L   +  G+ +V +G      L  A    + GE A ++T P+ K
Sbjct: 59  PAQ------LQLWEHPLDEVIVPGRPSVASGTASFAYLKTAIQRAIAGEVAGIVTAPISK 112

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE------LRVALATTHLPLRDIADAIT 177
                AG  F G TE     +    V M+           L   LATTH+PL+ +  A+T
Sbjct: 113 ACWQAAGYSFPGQTEVLAHLTGTAHVGMLFLGRSPVTHWVLTTLLATTHIPLQAVPRALT 172

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ- 236
           P  L+E +A+L   LR +  +  PRI + GLNPH+GE GH+G EE+  +IP L   + Q 
Sbjct: 173 PEGLNEKLALLIQFLRERRHLERPRIAIAGLNPHSGEQGHLGQEEVTWLIPWLAAAQQQY 232

Query: 237 -GMKLNGPLPADTLF---------QPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITL 286
             ++L GP+P DTL+         +P      DA LA+YHDQGL  +K   F   VN T+
Sbjct: 233 PEVELIGPVPPDTLWIGAADAWWGRPAPATAYDAYLALYHDQGLIPVKMLAFREAVNTTI 292

Query: 287 GLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           GLPFIRTS DHGTA ++AG G AD  SF+ A+  A  +   +
Sbjct: 293 GLPFIRTSPDHGTAFDIAGTGVADPQSFLAAIAWAQTLSKGS 334


>UniRef50_Q2CJB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Oceanicola
           granulosus HTCC2516 RepID=Q2CJB0_9RHOB
          Length = 338

 Score =  354 bits (910), Expect = 2e-96,   Method: Composition-based stats.
 Identities = 111/328 (33%), Positives = 166/328 (50%), Gaps = 8/328 (2%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + +TPG+  GIGP+LV ++       E   +V+  DA ++   A   G+ LTL P    +
Sbjct: 8   IALTPGDCTGIGPELVARIVHDGRLAEVARIVLVGDARVIERGARFAGVELTLAPVESPA 67

Query: 64  PAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            A       + ++ +    P  +  G+    +G    +TLARA +    G+  A+   P+
Sbjct: 68  KATFDGD-AVPIVDLGNIDPDALPLGEPDPTSGRLTGDTLARAIEFARAGKVDAISFAPL 126

Query: 122 HKGVINDAGIPFTG-HTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           +K  +   G  F   H  F    +       M   E   +   T+H+ LR+  D IT   
Sbjct: 127 NKRAMFLGGWEFPDEHKMFAHLLAHEGPFSEMNVLEGQWMTRVTSHVSLREAVDQITGPN 186

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +   + + H  +R K GI  PRI V  LNPH GEGG  G EEI+ I P + E+ A+G+  
Sbjct: 187 ICRALQLAHDTMR-KAGIETPRIAVAALNPHNGEGGLFGREEIEIIRPAVEEMAAKGIDC 245

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP P+DT++   +    D+VLAMYHDQG    K +GF +GV +T GL  I T+  HGTA
Sbjct: 246 TGPFPSDTVYLKAFAGEFDSVLAMYHDQGQIATKLRGFNKGVTVTAGLETIFTTPAHGTA 305

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNT 328
            ++ G+GKAD G+  TAL LA  ++   
Sbjct: 306 YDIVGQGKADTGASETALRLAATLVRQK 333


>UniRef50_Q87AJ1 4-hydroxythreonine-4-phosphate dehydrogenase n=7 Tax=Xylella
           fastidiosa RepID=PDXA_XYLFT
          Length = 330

 Score =  353 bits (907), Expect = 5e-96,   Method: Composition-based stats.
 Identities = 159/329 (48%), Positives = 197/329 (59%), Gaps = 7/329 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREW-PVELVVCADATLLTNRAAMLGLPLTLRPY 59
           M+    + + PGEPAG+GP+L V+L Q+      LV  AD   L   AA L     L   
Sbjct: 1   MLHPA-LALVPGEPAGVGPELCVRLVQQPRQDCRLVAFADPATLQAAAAAL----DLPLR 55

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
                A P+  G L +       P   G     N   V+  L  A   C++G    ++TG
Sbjct: 56  LLPPEALPERPGDLPIQAHCHVHPTRFGHPDPANAPAVIAALCEAASHCVHGVLHGIVTG 115

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           PVHK VIN +GI +TG TE    +++   VVMMLA   LRVAL TTHLPLRD+ DAIT A
Sbjct: 116 PVHKAVINQSGIHYTGTTELLAAQAEC-DVVMMLANPHLRVALVTTHLPLRDVPDAITAA 174

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
           LL   + I++  +   FGIA PRI V GLNPHAGE G++G EE+D +IPVL  LRA+GM 
Sbjct: 175 LLERCLRIVNTAMCGDFGIATPRIAVLGLNPHAGEEGYLGREELDVVIPVLQRLRAEGMV 234

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           L GPL ADT F P  L   DAV+AMYHDQGLPVLK+ GF + VNITLGLP+ R +VDHGT
Sbjct: 235 LLGPLSADTAFLPTKLIGYDAVVAMYHDQGLPVLKHSGFEQAVNITLGLPYPRVAVDHGT 294

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           AL+LAGRG AD  S   A  L  ++  + 
Sbjct: 295 ALDLAGRGVADPSSLFAATALCARLAASR 323


>UniRef50_A8ME07 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Archaea
           RepID=A8ME07_CALMQ
          Length = 325

 Score =  352 bits (903), Expect = 1e-95,   Method: Composition-based stats.
 Identities = 112/322 (34%), Positives = 167/322 (51%), Gaps = 18/322 (5%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
            R+ +T G+PAGIG ++V +   +     VEL +  +   L +   +LG+ L +     N
Sbjct: 2   PRIGVTLGDPAGIGYEIVAKALLKLSNPEVELTLIGN---LEHFKRVLGM-LKISDDVLN 57

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
                   G           P   G++  E G   +E++ R  +  + GE  AL T P++
Sbjct: 58  GVRFIDIPG----------GPFEFGKVQEEAGRVSLESVRRGVELAMAGEIDALATAPIN 107

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K     AG  +  HT   +  +++K+ + +  T  LR+   T H+PL D    I  A + 
Sbjct: 108 KEAWIKAGSSYIDHTTLLQALTKSKESLTVFETRRLRILFLTRHMPLADAIKEIKAANVL 167

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ-GMKLN 241
             I      L+   G+   RI V  LNPHAGEGG +G EEID I P + E R + G+   
Sbjct: 168 NGIINASRVLKA-LGVRRGRIAVAALNPHAGEGGLLGREEIDEITPAVKEARVKYGIDAY 226

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP+PAD++F      + D VL++YHDQG    K   F R V++TLGLPF+RTSVDHGTA 
Sbjct: 227 GPIPADSVFHLAAQGHYDIVLSLYHDQGHIAAKTYDFKRTVSLTLGLPFLRTSVDHGTAF 286

Query: 302 ELAGRGKADVGSFITALNLAIK 323
           ++AG+G AD  S + A+  A++
Sbjct: 287 DIAGKGIADETSMLEAIRKAVR 308


>UniRef50_Q30Z16 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Desulfovibrionales RepID=Q30Z16_DESDG
          Length = 365

 Score =  350 bits (899), Expect = 3e-95,   Method: Composition-based stats.
 Identities = 116/341 (34%), Positives = 161/341 (47%), Gaps = 19/341 (5%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREW---------PVELVVCADATLLTNRAAMLGLPLTL 56
            +++T G+  G+GP+L  ++   +             +V+      L     + G+    
Sbjct: 19  PLLVTMGDVNGLGPELACRVLGADGGRGALRYGVASPVVLLGSGKSLDTFMTLCGINGRF 78

Query: 57  -----RPYSPNSPAQPQTAGTLTLLPVALRAPVT--AGQLAVENGHYVVETLARACDGCL 109
                      +  +    G + L        VT   G+   + G      L  AC    
Sbjct: 79  WTAAADRQQLAALLEKARPGQVLLYEPPGMETVTVTPGKATADGGRAAGLALQEACSMLN 138

Query: 110 NGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQ--AKKVVMMLATEELRVALATTHL 167
           +G    ++T P+HK ++  AG  F GHTEF    +    + V M L  + LRV+L TTH 
Sbjct: 139 DGAATGVVTLPLHKAMLQQAGFDFPGHTEFLARHAGLRDEDVCMHLCGDVLRVSLVTTHP 198

Query: 168 PLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTII 227
            LRD+   +T   +   IA+    +R   G     + VCGLNPHAGE G +G E+   I 
Sbjct: 199 ALRDVPRLVTRQRVARCIALTVEFVRA-LGAGHKPVAVCGLNPHAGESGKIGVEDESIIA 257

Query: 228 PVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLG 287
           P + E +  G+   GP PADT+F         AVLAMYHDQGL  LK   F   VN+TLG
Sbjct: 258 PAVREAKRMGLNAEGPYPADTIFYRAAQGEFAAVLAMYHDQGLAPLKLLHFSDAVNVTLG 317

Query: 288 LPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           LPF+RTSVDHGT  ++AGR  AD GSF +AL LA  M    
Sbjct: 318 LPFVRTSVDHGTGFDIAGRNTADTGSFESALRLAADMCARR 358


>UniRef50_UPI00019F1502 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Citrobacter
           youngae ATCC 29220 RepID=UPI00019F1502
          Length = 336

 Score =  350 bits (899), Expect = 3e-95,   Method: Composition-based stats.
 Identities = 105/336 (31%), Positives = 164/336 (48%), Gaps = 9/336 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLR 57
           M     + I  GE AGIGP+LV ++       +    ++  DA +L     + G+     
Sbjct: 1   MKNKPVLGIFLGEAAGIGPELVAKVIADGTAYQYCKPIIIGDARVLALGQKIAGVSFPWE 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
             +  S A+    GT+ L+ +     A +  G +   +GH   E+L    +   +G+   
Sbjct: 61  TITDPSQAKWDN-GTVQLIDLKNYDPADLVMGTIDTVSGHATGESLITCMELLKSGKIDG 119

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQA--KKVVMMLATEELRVALATTHLPLRDIA 173
            +  P++K      G         F E+     +   ++   ++L V   T H+P RDI 
Sbjct: 120 FVFAPLNKEAFKKGGWHIEDEHYLFAEQLGCLDRPRGLLNVLDDLWVFRVTGHVPFRDIV 179

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL 233
             ITP  +   + + +  LR   G   PRI V  LNPHAG+GG  GTEEID +IPV+ E 
Sbjct: 180 KYITPENVGRSVQLCYDTLRM-AGYDNPRIAVAALNPHAGDGGTCGTEEIDVLIPVIEEY 238

Query: 234 RAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
           RA+GM + GP+P DTLF   +    DAV+ ++HDQG    K   F  GV +  GLP+  T
Sbjct: 239 RAKGMDIYGPVPGDTLFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGVTVAGGLPYAIT 298

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           + +HGTA ++AG+G A   +   A+++A  M +  +
Sbjct: 299 TPEHGTAFDIAGKGIAKTLATERAISVAANMALTNK 334


>UniRef50_A8S524 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8S524_9CLOT
          Length = 334

 Score =  350 bits (898), Expect = 5e-95,   Method: Composition-based stats.
 Identities = 90/320 (28%), Positives = 146/320 (45%), Gaps = 5/320 (1%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLR 57
           M     + I  G+ AG+GP+++V+LA   +       VV  D  +    A + GL + ++
Sbjct: 1   MSGKPILGILLGDAAGVGPEIIVKLAASRFYDEYCRPVVIGDVRVFERGARICGLEIPVQ 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                  A       +          V    +++E+G   +  L  A +    G      
Sbjct: 61  VIDKVEEADWTKGMPVLDQRDVDPEQVPFANISIESGRACLNMLKTAIELYQAGRIDGFC 120

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAI 176
             P++K  +  AG PF     +        +    +    +L     T+H+P+  ++D++
Sbjct: 121 FAPLNKQAMIQAGCPFESEHHYMAHLFGHTEPFGEINVLGDLWTTRTTSHIPISKVSDSL 180

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           T   +   I + +  L+   GI +PR+ +  LNPH GEGG  G EEID I P + + R  
Sbjct: 181 TVDTIMRAIRLANVSLKNS-GIEKPRLALAALNPHCGEGGKCGREEIDVIAPAIEKAREM 239

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G+  NGP P+D LF   +  + D V+ MYHDQG   LK +GF +G+ I  GLP    +  
Sbjct: 240 GIDANGPFPSDILFIKAFNGDFDGVVTMYHDQGQIALKLKGFDQGITIAGGLPAPIVTCA 299

Query: 297 HGTALELAGRGKADVGSFIT 316
           HGTA ++AG+G     +F  
Sbjct: 300 HGTAYDIAGKGIVKTSAFEN 319


>UniRef50_D2TK32 Putative uncharacterized protein n=1 Tax=Citrobacter rodentium
           ICC168 RepID=D2TK32_CITRO
          Length = 348

 Score =  349 bits (897), Expect = 6e-95,   Method: Composition-based stats.
 Identities = 102/333 (30%), Positives = 163/333 (48%), Gaps = 6/333 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +    + +  G+PAG+GP+LV ++            ++ AD   +    A+ G     R 
Sbjct: 1   MSLPVIAMVLGDPAGVGPELVAKVLSDRALLQKAHFILIADRDEMKKGMAIAGREFPWRD 60

Query: 59  YSPNSPAQPQTAGTLTLLP-VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
            +  + A       L +    +  AP   G+   ++G Y++ETL +A +   +G   A+ 
Sbjct: 61  VAAPTTADLTVGEALLIHHRCSHPAPFEYGKATAQSGVYILETLKKALELTQSGLAQAIC 120

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVM-MLATEELRVALATTHLPLRDIADAI 176
             P++K  ++  G+ F     +F  +         +   + +    AT+H+P RDI   +
Sbjct: 121 FAPLNKQAMHMGGLAFRDELHWFAHQLDWTPFCCEVNVVDNVWAGRATSHIPFRDIVSNL 180

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           +   + + I ++H+ LR   G A PRI V  LNPH GE G  G EE   I P + + R Q
Sbjct: 181 SIDGVLDTITLMHNTLRQ-AGFATPRIAVQALNPHGGENGLFGDEEQTIIRPAMEKARQQ 239

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G+ + GP PADT ++    +  DAV++MYHDQ    LK  GF RGV +  GLP   T+ +
Sbjct: 240 GINVFGPYPADTTWKAMQTEKLDAVVSMYHDQFATALKMLGFERGVTVQGGLPVPITTAN 299

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           HGTA  L G+  A   +F  A+ LAI+M   +Q
Sbjct: 300 HGTAYNLYGQNAATPSAFEQAVLLAIRMAKGSQ 332


>UniRef50_D0RQA4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=alpha
           proteobacterium HIMB114 RepID=D0RQA4_9RICK
          Length = 329

 Score =  348 bits (893), Expect = 2e-94,   Method: Composition-based stats.
 Identities = 96/331 (29%), Positives = 160/331 (48%), Gaps = 10/331 (3%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWP--VELVVCADATLLTNRAAMLGLPLTLRPYSP 61
            ++V +  G+P+GIGP+LVV+L   +      +VV  +  +L +   + G  +  +  + 
Sbjct: 2   KKKVAVLLGDPSGIGPELVVRLLNEDISNEANVVVIGEKKILEDGENISGKKVDFKFVTD 61

Query: 62  NSPAQPQTAGTLTL-LPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            +  +        L +          G+++ E+G  V+E +  A D     +  A+  GP
Sbjct: 62  FNEVKFNDKTKFFLDISKGTNRTYKRGEVSAESGKSVLEAMDYALDLAKEKKIDAINFGP 121

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMML-ATEELRVALATTHLPLRDIADAITPA 179
           ++K  +   G  +    +F + + + K+        +    A  T+H+P++++ + IT  
Sbjct: 122 MNKTSLMMGGCQYNDEHDFMQNKLEMKEFCCEFNVVDNFWTARVTSHIPIKEVPENITKE 181

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            + + I +L   L+   GI  PRI V  LNPHA      GTEE D IIP + E +  G+ 
Sbjct: 182 NILKPIKLLDQTLKMS-GIKNPRIAVQALNPHAE----FGTEEKDEIIPAIEEAKKMGIN 236

Query: 240 LNGPLPADTLFQPKYL-DNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            +GPLP DT F   +   N D ++ MYHD     LK  GF RGV ++ GL    T+  HG
Sbjct: 237 ADGPLPCDTSFITAFKNKNHDCIVGMYHDALQCGLKAFGFDRGVTVSGGLTVPVTTPAHG 296

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           TA ++ G   A++   I +  LA+KM   TQ
Sbjct: 297 TAFDIVGTNTANLEPTINSFKLAVKMNSGTQ 327


>UniRef50_UPI0000D5482C 4-hydroxythreonine-4-phosphate
           dehydrogenase,(4-(phosphohydroxy)-L-threonine n=1
           Tax=Psychroflexus torquis ATCC 700755
           RepID=UPI0000D5482C
          Length = 284

 Score =  344 bits (883), Expect = 2e-93,   Method: Composition-based stats.
 Identities = 122/284 (42%), Positives = 172/284 (60%)

Query: 42  LLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETL 101
           L   R A L   + +         +    G L ++  +  +    G+L   N  YV++ L
Sbjct: 1   LFVARTATLKKKVKILELDSLDQVKKNIKGHLQIIKTSKCSNTKPGKLYKSNAQYVLDNL 60

Query: 102 ARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVA 161
             +    +  +  AL+TGP+ K  I      FTGHTEF ++ +++K V+MMLA+++LRVA
Sbjct: 61  NYSIKQTMLNKRTALVTGPLSKENIISIDKSFTGHTEFIKKVTKSKDVLMMLASDQLRVA 120

Query: 162 LATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTE 221
           L+TTH+PL++++  IT  L+   + IL+ DL++KF I +P I V GLNPHAGE G +G E
Sbjct: 121 LSTTHIPLKNVSKKITKELIINKVKILNEDLQSKFNIHKPSIKVLGLNPHAGENGKIGRE 180

Query: 222 EIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRG 281
           E D I P + ELR + + ++ P+ ADT F  K L   DA L MYHDQ LPVLK   FGR 
Sbjct: 181 EQDHIKPAIRELRKKKINVSMPVSADTAFSNKSLKETDAFLGMYHDQVLPVLKTLSFGRS 240

Query: 282 VNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
           +NITLG+P IRTSVDHG AL++AG  K+D  S I A+  A K+I
Sbjct: 241 INITLGIPIIRTSVDHGVALDIAGTNKSDPSSLILAIKTAKKLI 284


>UniRef50_Q2KXH9 4-hydroxythreonine-4-phosphate dehydrogenase n=9 Tax=Bacteria
           RepID=Q2KXH9_BORA1
          Length = 348

 Score =  344 bits (882), Expect = 3e-93,   Method: Composition-based stats.
 Identities = 104/329 (31%), Positives = 156/329 (47%), Gaps = 6/329 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR----EWPVELVVCADATLLTNRAAMLGLPLTLR 57
            +   + +T G+ AGIGP++  ++  +         LVV  D  ++T     LG    + 
Sbjct: 5   PQIPLLAVTLGDVAGIGPEITAKMLMKHDALRQKARLVVIGDVDVMTEAVRRLGGDPAIV 64

Query: 58  PYSPNSPAQPQTAGTLTLLPVALR-APVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
                +     T GT+ +       A V  G+++   G   V  +  AC     GE   +
Sbjct: 65  RRVERTADVSNTPGTIEVYQAGPSLAGVKLGEISAAAGDGSVRFVTTACALARAGEVDGI 124

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
           +T P++K  ++ AG  + GHTE        K   ++L+  +L +  ATTH+ LR   + +
Sbjct: 125 VTAPLNKAAMHAAGHKWPGHTELLAHEFGVKTFSLVLSAGDLYIFHATTHVSLRQAIEDL 184

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           TPA +  V+  L        G  +  + V GLNPHAGE    G E+ D + P + E  A 
Sbjct: 185 TPARVRAVLR-LAGSFAKALGRGDQPVAVSGLNPHAGENRIFGDEDADILAPAVAEANAD 243

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G+   GP+PAD LF          V+A YHDQG    K      GVNIT+GLP +R SVD
Sbjct: 244 GILAAGPIPADALFPQAVRGKWQFVIACYHDQGHAPFKSVYGDDGVNITVGLPVVRVSVD 303

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMI 325
           HGTA ++AG+G A   S + A   A  ++
Sbjct: 304 HGTAFDIAGQGIAREDSLVLAAERAAALV 332


>UniRef50_B8IXF1 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Methylobacterium nodulans ORS 2060
           RepID=B8IXF1_METNO
          Length = 336

 Score =  343 bits (881), Expect = 5e-93,   Method: Composition-based stats.
 Identities = 107/316 (33%), Positives = 169/316 (53%), Gaps = 9/316 (2%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLA---QREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
              + +T G+ AGIGP++VV+     +       +V  DA ++ +  A+ GLP  +R  S
Sbjct: 6   KPVIGVTMGDAAGIGPEIVVRALVEPEVREACHAIVIGDAGIMRDAVALTGLPCEIRAVS 65

Query: 61  PNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
             + A+ +  GT+ +L +    R+    G+++   G   VE + RA    L+GE  A+ +
Sbjct: 66  SVAEAEFRD-GTIDVLDLRNIARSDFEPGRISAACGRAFVEYIRRAARMALSGEIDAVAS 124

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P +K  ++ AG  + G TE F E S++     +L   ++RV L ++H+ L      +T 
Sbjct: 125 APTNKEAMHAAGEIYPGQTEIFAEESRSTDPFTILTGGKMRVFLVSSHVSLSQAIALVTQ 184

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             +  VI      L+  +GI +P I V GLNPHAG+GG  G EEI+ +IPVL  LRA+G+
Sbjct: 185 PRIELVIRKAVASLKELWGIDDPLIGVAGLNPHAGDGGLFGREEIEHVIPVLERLRAEGI 244

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           ++ GP PAD+++        D V+ MYHDQG+  LK  G+   V +  G P IRT+  HG
Sbjct: 245 RIEGPGPADSVYDRADRGAYDGVIGMYHDQGVIPLKRYGY---VTVISGTPIIRTTAGHG 301

Query: 299 TALELAGRGKADVGSF 314
           TA ++A +G       
Sbjct: 302 TAYDIAWKGIGRANVM 317


>UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=10
           Tax=Proteobacteria RepID=PDXA2_PSEAE
          Length = 337

 Score =  343 bits (881), Expect = 5e-93,   Method: Composition-based stats.
 Identities = 104/331 (31%), Positives = 161/331 (48%), Gaps = 8/331 (2%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
            R+ +  G+PAGIGP+L+ +L           +V+ AD   +     + G     R    
Sbjct: 7   PRLAMVLGDPAGIGPELIARLLADTEVREKAHIVLIADEAEMRRGMRIAGCEFPYRRIDA 66

Query: 62  NSPAQPQTAG-TLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
                   A   L              + +   G Y +ETLA A +   +G   A++ GP
Sbjct: 67  LETLDFADATPLLHPWLSQGGDEFPRSEASAVGGRYSLETLALALELTRSGRTDAILFGP 126

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           ++K  ++ AG+  +    +F ER             ++L  +  T+H+ L ++   ++  
Sbjct: 127 LNKTSLHMAGMDHSDELHWFAERLGFGGPFCEFNVLDDLWTSRVTSHVALAEVPGLLSQE 186

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            + E I ++   LR + G+A PRI VCGLNPH G+ G  G EE+D I P + + R QG+ 
Sbjct: 187 RVGEAIRLIDDALR-RSGLARPRIGVCGLNPHNGDNGSFGREELDIIAPAVQKAREQGIA 245

Query: 240 LNGPLPADTLFQPKY--LDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
            +GP PADT+F          DAV+ MYHDQG   +K  GF RGV +  GLP    +  H
Sbjct: 246 ADGPYPADTIFLKVQGDARAFDAVVTMYHDQGQIAIKLMGFSRGVTVQGGLPIPIATPAH 305

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNT 328
           GTA ++AG+G+ADVG+   A  +A +M  + 
Sbjct: 306 GTAFDIAGQGRADVGATRQAFEIACRMGRHK 336


>UniRef50_Q92TP3 4-hydroxythreonine-4-phosphate dehydrogenase 3 n=8 Tax=Rhizobiales
           RepID=PDXA3_RHIME
          Length = 348

 Score =  342 bits (878), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 102/328 (31%), Positives = 159/328 (48%), Gaps = 6/328 (1%)

Query: 7   VVITPGEPAGIGPDLVVQLAQ---REWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + +  G+PAGI P+L  +L           ++   D  +L   A + G+ L L   S ++
Sbjct: 16  IALAMGDPAGISPELTARLLALSDIRDAAHIIAIGDRRILDEGARVAGVTLDLEAASLDA 75

Query: 64  PAQPQTAGTLTL-LPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
                TA  + + L     A V  G+  +  G +       A +    G+  A+   P +
Sbjct: 76  LDNAGTARHVFVDLAHLDPADVVRGEATLAGGTFATRNFRTALELAHAGKADAVCFTPFN 135

Query: 123 KGVINDAGIPFTGHTEFFEE-RSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           K  +  A   +     F  +  S   KV      E++  A  T+H+PL+D+A  ++   +
Sbjct: 136 KKAMRFAYPGYDDEIRFVADVLSFTGKVREFNVLEKVWNARVTSHIPLKDVASHLSVEAI 195

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
              + +    L+   G  E +I V GLNPHAG+GG  G EEID I P + + RA G  + 
Sbjct: 196 LAELKLTQACLK-DAGYEEAKIAVAGLNPHAGDGGSFGMEEIDIIEPAVEKARALGFNVE 254

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP PADT+F     +  +AV+ MYHDQG   +K  GF +GV +  GLPF   +  HGTA 
Sbjct: 255 GPFPADTVFLRALKEGFNAVMTMYHDQGQIAMKIIGFDKGVTMMGGLPFPLCTPAHGTAY 314

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNTQ 329
           ++AG+G AD+G+   A+ LA +M    +
Sbjct: 315 DIAGKGIADIGATREAILLAARMAKKKR 342


>UniRef50_Q9CKG8 4-hydroxythreonine-4-phosphate dehydrogenase n=3
           Tax=Gammaproteobacteria RepID=PDXA_PASMU
          Length = 337

 Score =  342 bits (878), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 97/330 (29%), Positives = 162/330 (49%), Gaps = 8/330 (2%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +    V +T G+PAGIGP+LV +L  +        +V+ AD   L     +         
Sbjct: 1   MTKSTVALTLGDPAGIGPELVAKLLAKQNIREKANIVLVADKDELEKGMEIAKAQFVYEE 60

Query: 59  YSPNSPAQPQTAGTLTLL---PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
            S +   Q +    + +L     +   P   G++  ++G Y++ETL  A +    G   A
Sbjct: 61  VSFHQLGQYEFKTGVPVLISHKSSHPKPFEYGKVTEQSGVYILETLKVALNLAKMGYVQA 120

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMML-ATEELRVALATTHLPLRDIAD 174
           +   P++K  ++  G+ +     +F E++   + V  L   +++  A  T+H+P +DI  
Sbjct: 121 ICFAPLNKQAMHKGGLRYRDELHWFAEQTDFNEFVCELNVVDDIWAARVTSHIPFKDIVP 180

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            ++   + + I +L+  L    G+  P+I V  LNPH GEGG  G EE+  I P + + R
Sbjct: 181 NLSIKGVFDCIHLLYRSLVQ-AGVENPKIAVQALNPHGGEGGVFGDEEMTIIQPGMEQAR 239

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
             G+ + GP P DT  +       + V++MYHDQ    LK  GF RGV +  G+P   T+
Sbjct: 240 KAGIDVYGPFPGDTTMREVERLKINGVVSMYHDQFSTALKILGFERGVTVQGGIPIPITT 299

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKM 324
            +HGTA +L G+  A   +F  A N+A++M
Sbjct: 300 ANHGTAFDLHGKNIAIPTAFEAAFNIAVRM 329


>UniRef50_B4U950 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Aquificaceae
           RepID=PDXA_HYDS0
          Length = 310

 Score =  341 bits (875), Expect = 3e-92,   Method: Composition-based stats.
 Identities = 107/314 (34%), Positives = 169/314 (53%), Gaps = 15/314 (4%)

Query: 8   VITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
            IT G+PAGIGP+L+++L +  E     V+  +  +L + +++LG        +     +
Sbjct: 5   GITMGDPAGIGPELILKLQKDMEDENAYVIYGEEYILKHASSVLGQNFYYEKVNSVDDVK 64

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
            +    + L+ ++L+  +   + +  +G   +  LARA    ++ +   ++T P++K   
Sbjct: 65  DKG---IYLISLSLKGAL---EPSPSSGKLAIAYLARATADAISKKLNGILTMPINKYFA 118

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIA 186
             +G  F G TE+       K   MM+ ++ ++V LAT H+PL+DIA+AI   L+ + I 
Sbjct: 119 KASGFSFNGQTEYLAFADNKKDFAMMMYSDAIKVVLATIHIPLKDIANAINVELIKQKIK 178

Query: 187 ILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPA 246
           ++  D   K+    P I V GLNPHAGEGG +G EE   IIP + +       + GP+P 
Sbjct: 179 LI-KDYIPKYFRFIPTIKVLGLNPHAGEGGLIGDEEAKIIIPAIRD-----EDVVGPIPP 232

Query: 247 DTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGR 306
           DT F    +   D  L MYHDQGL   K   F +G N+T+GL F+RTS DHGTA ++A +
Sbjct: 233 DTAFID--IKKDDIFLCMYHDQGLIPFKMLAFDKGSNVTIGLSFLRTSPDHGTAYDIAYK 290

Query: 307 GKADVGSFITALNL 320
           G A V S   +L L
Sbjct: 291 GLARVDSAGYSLEL 304


>UniRef50_Q1DF36 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Cystobacterineae RepID=Q1DF36_MYXXD
          Length = 346

 Score =  340 bits (873), Expect = 4e-92,   Method: Composition-based stats.
 Identities = 120/329 (36%), Positives = 165/329 (50%), Gaps = 12/329 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSP 61
             V I+ G+ +GIGP++      +    +    V+  D   L    A            P
Sbjct: 4   PHVGISLGDVSGIGPEVTAAALTKPSVRKVLVPVIFGDGPTLARFPAFR----RYARVEP 59

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           ++  + +    + +  +A +  V  G+ + E G      +  A D    G   AL T PV
Sbjct: 60  SALGRVEGPTVVEVTRLAEKDRV-PGEPSREGGRAQYAFVTAAIDAMRAGHVDALCTAPV 118

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
            K  I+ AGIPF GHTE   E      V+M++    +RVALAT H+PL D+   +T   L
Sbjct: 119 SKEQISRAGIPFMGHTEVLAEAFGV-DVMMLMDGPRVRVALATNHVPLADLPRLLTVDGL 177

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
              + +L   L    G  +PRI V GLNPHAGEGG +G EE++ I P + + RA  +  N
Sbjct: 178 TAQLKLLSRSLEPVVG-HKPRIAVLGLNPHAGEGGLLGREEVEVIGPAIRKARAARVDAN 236

Query: 242 GPLPADTLFQP--KYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           GP+PAD LF    +     DAVLAMYHDQGL   K   F R VN+TLGLP  RTS DHGT
Sbjct: 237 GPIPADGLFAKPDEVGARYDAVLAMYHDQGLIPAKALDFERTVNVTLGLPVPRTSPDHGT 296

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           A  +AG+G+A     + AL  A ++    
Sbjct: 297 AYAIAGKGEASCVPMVEALLKAAQLAGAR 325


>UniRef50_B8FR92 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Desulfitobacterium hafniense RepID=B8FR92_DESHD
          Length = 342

 Score =  339 bits (871), Expect = 6e-92,   Method: Composition-based stats.
 Identities = 91/327 (27%), Positives = 156/327 (47%), Gaps = 5/327 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
              + +T G+PAG+GP++V + A +         ++  D  L      +  + +  +  +
Sbjct: 7   KPVIGVTMGDPAGVGPEIVAKAAAQGILAKDAHPIIVGDQRLFKRGMEIAKVRVDFQVAA 66

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
               A       +        A +  G+L  E G      +      C  G    +   P
Sbjct: 67  TLEEALTMDGIVVLDTRKFDAADLVMGELREECGRDAATNIQTCVQYCRQGLMDGICFAP 126

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
            +K  +  AG    G  +      Q       +   +++  A  T+H+P++DI+  +T  
Sbjct: 127 NNKAAMKKAGFVLHGAIDLLAGFFQFTGNRGELNVLDDVWTARVTSHIPVKDISARLTEE 186

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +   I +++  L+ + GIA+PRI V  LNPH GEGG  G EE++ I P + + +A G++
Sbjct: 187 GILNSIHLVNDTLK-RAGIAKPRIAVAALNPHGGEGGTCGREEVEVIAPTVEKAKAMGIE 245

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
            +GP PADTLF   +    DA + M+HDQG   +K +GF +GV +  GLP   T+  HG+
Sbjct: 246 TDGPFPADTLFIKLFNREYDAAVTMFHDQGQIAMKLKGFDQGVTVMAGLPNPVTTCSHGS 305

Query: 300 ALELAGRGKADVGSFITALNLAIKMIV 326
           A ++AG+G A+ G++  +  L +KM  
Sbjct: 306 AFDIAGKGIANPGAWGNSYGLVVKMAA 332


>UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Octadecabacter
           antarcticus 238 RepID=B5KE47_9RHOB
          Length = 343

 Score =  339 bits (870), Expect = 8e-92,   Method: Composition-based stats.
 Identities = 102/332 (30%), Positives = 170/332 (51%), Gaps = 6/332 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +   ++ I PG+P+GIGP+L+ QL   +      ++++  D  +    A   G+ L L P
Sbjct: 6   MTKPKIAIIPGDPSGIGPELIAQLLASDGVSEAADILLVGDTHIWEQGARQAGVRLQLDP 65

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
            +  + A+      L +  + + A V   ++ +++G   + TL +A D  + G    ++ 
Sbjct: 66  IAWANLAEFSGLRQLEMETIDV-ADVKVAEVTIQSGKSALRTLDQALDLAVAGIVDGVLF 124

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKV-VMMLATEELRVALATTHLPLRDIADAIT 177
           GP +K  +  AG+       +       K     +   ++L     T+H+ LR++AD IT
Sbjct: 125 GPFNKAALTAAGLNAEDEHRYMARYLGFKGYHSEVNVLDDLMTTRVTSHIGLREVADNIT 184

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              + + I + H  L  K G + P + V  LNPHAG+ G  G EEID + PV+ E + + 
Sbjct: 185 ADGVRKAIMMAHDTL-AKAGKSRPHVAVAALNPHAGDNGKFGREEIDILAPVVAEYQGRH 243

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           M ++GP P+DT+F        DAV+ MYHDQG   +K  GF RGV +  GLP    +  H
Sbjct: 244 MHVSGPWPSDTVFLKAKAGEVDAVVTMYHDQGQIAIKLMGFDRGVTVAGGLPIPVVTPAH 303

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           GTA ++AG+  A+VG+   A NL +++ V  +
Sbjct: 304 GTAFDIAGQSVANVGATRNAFNLLLRLAVTHR 335


>UniRef50_B9XEU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=bacterium
           Ellin514 RepID=B9XEU4_9BACT
          Length = 330

 Score =  338 bits (868), Expect = 2e-91,   Method: Composition-based stats.
 Identities = 128/328 (39%), Positives = 170/328 (51%), Gaps = 13/328 (3%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPV---ELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + I  G+  GIGP++ ++    E        ++  DA LL      L L L   PYS   
Sbjct: 5   IGICLGDVTGIGPEVTLKALAAEAGADDTRYLLIGDAGLLQKLNQGLNLNLDFHPYS--G 62

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
           P          L+P AL   +  G       +  V  L  A   CLN E   +IT PV+K
Sbjct: 63  PRNGGRIFVHDLMPGALPENLKPGAPEAA--NAAVAWLKDATQRCLNHELDGMITAPVNK 120

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE-----LRVALATTHLPLRDIADAITP 178
             I  AG  F G TEF    + A +  MML   +     LRV LATTH+PL+ +++ +T 
Sbjct: 121 ESIIRAGHAFVGQTEFISNMAGADRSAMMLLGHDDRDRWLRVVLATTHVPLKAVSEKLTQ 180

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
           A +   I           G+   R+ VCGLNPHAGEGG +GTEEI  + P +   + + +
Sbjct: 181 AKVELAIERAAQSC-VDLGLPRARVAVCGLNPHAGEGGELGTEEITVVTPAVEACKRKNL 239

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            ++GP PAD LF   +  + D V+AMYHDQGL  LK  GF  G+N TLGLPFIRTS DHG
Sbjct: 240 DVHGPFPADALFHYVFKGDYDVVVAMYHDQGLVPLKMIGFENGINWTLGLPFIRTSPDHG 299

Query: 299 TALELAGRGKADVGSFITALNLAIKMIV 326
           TA  +AGRG A+  S I A+ LA ++  
Sbjct: 300 TAYNIAGRGIANPSSMIAAIRLAKQLAR 327


>UniRef50_C3JBU1 4-hydroxythreonine-4-phosphate dehydrogenase n=5 Tax=Bacteria
           RepID=C3JBU1_9PORP
          Length = 371

 Score =  338 bits (867), Expect = 2e-91,   Method: Composition-based stats.
 Identities = 106/330 (32%), Positives = 160/330 (48%), Gaps = 10/330 (3%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLP-LTLR 57
            +   + IT G+  GIG +++ +        EL   ++   A         L +     R
Sbjct: 6   NRKPVIGITHGDINGIGYEVLFKAFAEANITELFTPIIYGSAEAEAFWRNYLTVETAPWR 65

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
             + +  A+      ++         V  G      G    + L RA +  LN    AL+
Sbjct: 66  KITTSGEAKEGEINLISC--TTQNVQVEVGVPTPLAGRCAFDALERAMEDALNNRIDALV 123

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKK---VVMMLATEELRVALATTHLPLRDIAD 174
           T P++K  +     PF GHT++   +   K+    +M+L + ++RVALATTH+ + ++A 
Sbjct: 124 TAPINKATMPQDLFPFKGHTDYLGAKCGLKENESPLMILTSGDIRVALATTHVAISEVAG 183

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            ++ +LL E +  +   ++  F I +PRI V  LNPH+G+ G MG EEI+ I P L + R
Sbjct: 184 LLSESLLLEKLQAIESSMQRDFDIEKPRIAVLSLNPHSGDRGLMGREEIEIITPTLQKAR 243

Query: 235 AQ-GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
            Q  +   GP  AD  +    L   DA+LA+YHDQGL   K      GVN T GLP IRT
Sbjct: 244 EQHKLLAFGPFAADGFWGSAELYKYDAILALYHDQGLAPFKSLFMNEGVNFTAGLPIIRT 303

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIK 323
           S DHGT  ++AG+  A   S   A+ LAI 
Sbjct: 304 SPDHGTGYDIAGKNLASSASLTAAIYLAID 333


>UniRef50_C5CPN5 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Variovorax
           paradoxus S110 RepID=C5CPN5_VARPS
          Length = 354

 Score =  337 bits (866), Expect = 3e-91,   Method: Composition-based stats.
 Identities = 100/329 (30%), Positives = 159/329 (48%), Gaps = 8/329 (2%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPYSP 61
            R+ +  G+P GIGP++ V+L  R+       +++ AD  +L     + G+ L       
Sbjct: 15  PRIAVLLGDPGGIGPEMAVKLLARQRNLDAARVLLIADPVVLAAGERVAGVKLDPLRIDG 74

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTA--GQLAVENGHYVVETLARACDGCLNGEFAALITG 119
               + +  G  TLL            G+    +G    E L  A      G+   ++  
Sbjct: 75  LDDLRFEH-GRPTLLQRDWMQGREPVLGESNEASGRASFEALELATAAVRRGQAEGIVFA 133

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMML-ATEELRVALATTHLPLRDIADAITP 178
           P++K  +   G+       + +ER      V     T  L  +  T+H+PL+D+A  IT 
Sbjct: 134 PLNKHSLRLGGLVHEDELRYMQERFAVTGFVCEFNLTGSLWTSRVTSHIPLKDVASHITV 193

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + + + I+   LR + G+A+PRI V GLNPHAG+GG +G EEI+ I P +  LRA+G 
Sbjct: 194 EGVGDAVKIIASALR-RAGVAQPRIAVTGLNPHAGDGGSIGMEEIEIIAPAIERLRAEGY 252

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
              GP   DT+F      + DAV++MYHDQG   +K  GF +GV +  GLP    +   G
Sbjct: 253 DARGPFSPDTVFIGARRGDVDAVVSMYHDQGQIAMKLMGFEQGVTLHGGLPVPVATSASG 312

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVN 327
           +A ++AG+G A +     A +L ++M   
Sbjct: 313 SAFDIAGKGVAQIEGLQQAFDLCVRMASG 341


>UniRef50_Q390F1 4-hydroxythreonine-4-phosphate dehydrogenase n=22
           Tax=Proteobacteria RepID=Q390F1_BURS3
          Length = 351

 Score =  336 bits (862), Expect = 7e-91,   Method: Composition-based stats.
 Identities = 97/334 (29%), Positives = 154/334 (46%), Gaps = 12/334 (3%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           V +T G+PAGIG +L+ +L  R        LV+  D  L      + G+ + + P +  +
Sbjct: 13  VALTLGDPAGIGAELIAKLLARPDATTHANLVLIGDRWLWEAGQRVAGVTVDVEPVASLA 72

Query: 64  PAQ---PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
             +            +     A VT GQ     G   +  L    D  L G+  A+   P
Sbjct: 73  AVRNRPSTARAAFVAIDTIDPADVTVGQPGAAGGRSTLTVLDLCLDAALAGDIDAICFAP 132

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           ++K  +   G+        F E               EL  A  ++H+PL+D    ++  
Sbjct: 133 LNKYAMKLGGLKHEDELHHFAEALGVTGYFCEFNTLGELWTARISSHIPLKDAPGYLSIE 192

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            + +   +++  L    G+A P++ +   NPH G+GG  G EE+D I P + +L+++   
Sbjct: 193 RIEQASELIYRSLLAN-GVAAPKVAIAAFNPHGGDGGSCGREEVDIIEPAVRQLQSRDWP 251

Query: 240 ----LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
                +GP PADT+F      +  A++ MYHDQG   +K  GF RGV +  GLP   T+ 
Sbjct: 252 TDAPFHGPFPADTIFLKAQAGDYQAIVTMYHDQGQIAIKLLGFSRGVTVQGGLPVPITTP 311

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
            HGTA ++AGRG ADVG+   AL +A +M    +
Sbjct: 312 AHGTAYDIAGRGTADVGATWQALQIACRMGAARR 345


>UniRef50_B1GZF5 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=B1GZF5_UNCTG
          Length = 318

 Score =  335 bits (859), Expect = 2e-90,   Method: Composition-based stats.
 Identities = 98/325 (30%), Positives = 156/325 (48%), Gaps = 19/325 (5%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +   R+ IT G+PAG+G ++V +       +     V+  D   L        L   L+ 
Sbjct: 1   MTKPRLAITLGDPAGVGCEIVCRAVSSSAVKRVCSPVIFGDKQSLKR-----SLLKYLKN 55

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
             P    +    G            V  G  + + G      + +A   C NG+  AL+T
Sbjct: 56  RMPFEFVESSNIG----------DSVKMGAPSKKAGIIAASAIYKAVKYCANGKALALVT 105

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            PV K  +  +GI + GHTE     + +KKV MM+    +   + T H+P+  I++ I  
Sbjct: 106 APVSKESLKMSGIKYPGHTELLASLTNSKKVAMMMTCGNIHGVMVTRHIPVSKISENIKT 165

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + E + +  + LR K G    ++++CGLNPHAG+   +G EE   I+P    ++  G+
Sbjct: 166 KTIVEAVNLSVNFLR-KAGKKNIKVVLCGLNPHAGDNSILGFEEKKFILPAYKIIKKSGI 224

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            +  PL AD+ +        D + AMYHDQ +  LK     + VN+T+GLPF+RTS  HG
Sbjct: 225 DITKPLSADSAWLKTKNGQYDLICAMYHDQIMIALKCINAAKIVNVTIGLPFVRTSPGHG 284

Query: 299 TALELAGRGKADVGSFITALNLAIK 323
           TA  +AG+ +AD  + I A+  A +
Sbjct: 285 TAFNIAGKNEADASAMIEAILYAAR 309


>UniRef50_B1ZQS3 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Opitutus
           terrae PB90-1 RepID=B1ZQS3_OPITP
          Length = 336

 Score =  332 bits (851), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 122/354 (34%), Positives = 170/354 (48%), Gaps = 50/354 (14%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPV--ELVVCADATLLTNR-AAMLGLPLTLR 57
           +  T ++ +T G+PAG+GP+++         V  ++VV      L +  A +  + + L 
Sbjct: 4   LPNTTKLALTCGDPAGVGPEVIASWLASPAAVSQDVVVIGPPRWLESLPAGVRKIAVGLE 63

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
            +S                        T G    +        + RA +GC  GEF  ++
Sbjct: 64  DFSA-----------------------TPGAPDADGALVAWAAIERAAEGCRQGEFCGVV 100

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           TGP+ K  +   G PF G TEFF  R   + V M  A   LRV LAT H+PL ++   + 
Sbjct: 101 TGPISKERLAKIGYPFPGQTEFFAARWGGEPV-MAFAGGRLRVVLATWHIPLHEVGGRLG 159

Query: 178 PALLHEVI-------------------AILHHDLRTKFGI----AEPRILVCGLNPHAGE 214
           P LLH                      AI  + +  ++G      +PRI VCGLNPHAGE
Sbjct: 160 PHLLHRAAQAATEIARIDCRAGAPVHAAIGANAVNDRWGQGIPPDKPRIGVCGLNPHAGE 219

Query: 215 GGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLK 274
           GG +G EE D I P L+ LR +   L+   PADT+F        D V+A+YHDQGL  LK
Sbjct: 220 GGLLGYEERDFIDPALDHLRTEFAGLSRCQPADTIFARALQGEFDVVIALYHDQGLAPLK 279

Query: 275 YQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
              F   VN+TLGLPF+RTS DHGT   +AG+G A   SF  A+ +A ++I   
Sbjct: 280 TIDFDESVNVTLGLPFVRTSPDHGTGFGIAGKGVARATSFANAVTVARQLIAAR 333


>UniRef50_B2KET4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Elusimicrobium
           minutum Pei191 RepID=B2KET4_ELUMP
          Length = 309

 Score =  330 bits (846), Expect = 5e-89,   Method: Composition-based stats.
 Identities = 109/326 (33%), Positives = 160/326 (49%), Gaps = 21/326 (6%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREW---PVELVVCADATLLTNRAAMLGLPLTLRPYS 60
              + IT G+P GIGP++VV+  Q +        VV  D   L                +
Sbjct: 2   KPLIAITTGDPMGIGPEIVVKALQDKRVTDACTPVVIGDKKAL--------------IKN 47

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
                      T  +L   L  P T G   V  G      +  A      GE  A++T P
Sbjct: 48  GLQEGAFSVVDTAAILTKPL--PETPG-PTVYGGLTSFNAVTMASRITSKGEVKAMVTAP 104

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           + K   N AG+ +TGHT+F +E S+   V+MM  T +L V L + H  ++D++  IT   
Sbjct: 105 ISKESWNMAGVKYTGHTDFLKEFSRIDHVLMMFTTNKLTVGLVSEHAAIKDLSKEITSKK 164

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +     +L++ L +   + +PRI V  +NPHAG+GG +G EE + I P L+ L+ +   +
Sbjct: 165 IIHAAQLLNNFLISN-SVKKPRIGVSAVNPHAGDGGKLGMEEKEIIAPALSVLKKENFNI 223

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+P D L+        D +L MYHDQ L  LK       V++T GLPFIRTS  HGTA
Sbjct: 224 LGPMPVDALWTKYTKGAYDGILCMYHDQALLGLKLCAQEPIVHLTYGLPFIRTSPTHGTA 283

Query: 301 LELAGRGKADVGSFITALNLAIKMIV 326
            ++AG+ +AD  S I+A+  A+  I 
Sbjct: 284 FDIAGKNEADPSSMISAILYAVSHIK 309


>UniRef50_A6FY83 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Plesiocystis
           pacifica SIR-1 RepID=A6FY83_9DELT
          Length = 327

 Score =  329 bits (845), Expect = 6e-89,   Method: Composition-based stats.
 Identities = 125/332 (37%), Positives = 169/332 (50%), Gaps = 25/332 (7%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           +VIT G+P G+GP+L++++A      E V+  +  +   RA + GL  +L        A 
Sbjct: 4   LVITQGDPDGVGPELLLRMAA-----EGVLLPEDRVFAGRAKLRGLAESL----TAEWAA 54

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARAC----DGCLNGEFAALITGPVH 122
           P  A    LL  +L                  E L R      +    G  AAL+T P+ 
Sbjct: 55  PGWAKLEPLLDPSLAER------DPSAPLGQFEALERGVDRVLEDVRKGAPAALVTAPID 108

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K V +  G+   GHTE+  ER+  +   M++A   +RV LAT HLPLR + +A+  A + 
Sbjct: 109 KAVASREGLRHPGHTEYLAERAGVEDFAMLMAGSTIRVVLATIHLPLRAVVNALDQAAIV 168

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK--- 239
              ++L   L   +G+AEP + V GLNPHAGEGG +G EE   I P +  L A   +   
Sbjct: 169 RAGSLLARSLVQDYGVAEPVVGVLGLNPHAGEGGLLGDEEQTLIAPAIEALGAWAAQAQI 228

Query: 240 ---LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
                GPLPADT F          ++AMYHDQGL   K   F  GVN+TLGLPF+RTS D
Sbjct: 229 PARFVGPLPADTAFHHNRGGRVHGLVAMYHDQGLGPFKLAHFSDGVNVTLGLPFVRTSPD 288

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           HGTA ++AGRG AD  S   A+ LA  M    
Sbjct: 289 HGTAKDIAGRGVADASSMRAAIELARAMSRAR 320


>UniRef50_Q30S58 4-hydroxythreonine-4-phosphate dehydrogenase n=11
           Tax=Epsilonproteobacteria RepID=PDXA_SULDN
          Length = 307

 Score =  329 bits (845), Expect = 7e-89,   Method: Composition-based stats.
 Identities = 93/326 (28%), Positives = 153/326 (46%), Gaps = 26/326 (7%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           +   R+ I+ G+  G+G ++ ++  +        + C ++ +L   + +L   +      
Sbjct: 1   MSKVRIAISVGDLNGVGIEIAIKAHEEVSKLCAPLYCINSYMLNQASTLLNYKIPSN--- 57

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
                         +  V     V  G +  ++G Y  ++   A   C   +  A++T P
Sbjct: 58  ------------FEISEVGGEFAVKKGCVDKDSGRYSYDSFIHAISLCEQKKADAVVTMP 105

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           +HK     AG+ + GHT+   E  + +  +MML  +++ VAL + H+PL+D+A +I    
Sbjct: 106 IHKEAWMLAGLKYKGHTDLLREHFK-RDAIMMLGCQKMFVALFSEHIPLKDVASSIKYKK 164

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ--GM 238
           L +        L     +   R+ V GLNPHAG+ G +G EE+  I   +     +    
Sbjct: 165 LKQF------FLDFNNSVPNERVAVLGLNPHAGDNGVLGNEEL-IITKAIKSANKKVCFE 217

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           +  GPL  D  F P   +     +AMYHDQGL  LK   F   +N++L LP IRTSVDHG
Sbjct: 218 QFIGPLVPDIAFTPHIREKFKYFIAMYHDQGLAPLKALYFDESINVSLNLPIIRTSVDHG 277

Query: 299 TALELAGRGKADVGSFITALNLAIKM 324
           TA ++A   KA   S+I A+  AI +
Sbjct: 278 TAFDIAYEKKAKTLSYINAIKSAIAL 303


>UniRef50_C5SNX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Asticcacaulis
           excentricus CB 48 RepID=C5SNX7_9CAUL
          Length = 319

 Score =  329 bits (844), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 111/316 (35%), Positives = 161/316 (50%), Gaps = 19/316 (6%)

Query: 25  LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRAPV 84
             + +      V  DA LL +    LG    ++  +  S A       L +L   L AP 
Sbjct: 7   ALRSQTQYAFTVLGDADLLAS----LG---PVQRLTDLSDAIAAFPDALPVLDRPLSAPP 59

Query: 85  TAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERS 144
             G     +  ++   +    + CL+G    LIT P+ K V+  +G  F GHTE+  + +
Sbjct: 60  LPGNPDPVHAPHITSWIREGVELCLSGAARGLITAPIAKSVLYASGFAFPGHTEYLGDLT 119

Query: 145 ------QAKKVVMMLATEE------LRVALATTHLPLRDIADAITPALLHEVIAILHHDL 192
                   +  VMML   +      LRV LAT H PL ++   ++   +  +  + H  L
Sbjct: 120 AAAPYPGTRGPVMMLTAPDAVNESALRVVLATIHTPLSEVKAHLSAETVRTLAHVTHEAL 179

Query: 193 RTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQP 252
              FG+A+PR+++ GLNPHAGE G +G EE+D + P++  L  +G+ ++GPLPADTLF  
Sbjct: 180 IRDFGVAKPRLVLAGLNPHAGEDGTIGREEVDLLQPLVAALCNEGLDISGPLPADTLFHA 239

Query: 253 KYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVG 312
           +     DA L +YHDQGL  LK   F  GVNITLGLP +RTS DHGT   + G+G A   
Sbjct: 240 EARRTYDAALCLYHDQGLIPLKTLDFWGGVNITLGLPLVRTSPDHGTGFAIVGKGIARPD 299

Query: 313 SFITALNLAIKMIVNT 328
           S I A+  A  + +N 
Sbjct: 300 SLINAIRAAHDISLNR 315


>UniRef50_B4D0B0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Chthoniobacter
           flavus Ellin428 RepID=B4D0B0_9BACT
          Length = 296

 Score =  328 bits (843), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 110/326 (33%), Positives = 152/326 (46%), Gaps = 42/326 (12%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
             + + +T G+ AGIGP+++                           L      R    +
Sbjct: 4   SPKTIGLTLGDAAGIGPEIIKAALASGR-------------------LNKDFQYRVIGSS 44

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
             A                     G           E L  +    L GE AA++TGP+H
Sbjct: 45  DGA-------------------KPGAPTESTARAAREALEESARLALAGEIAAVVTGPIH 85

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K  +   G  F G TEF+  R++ +   M L    L VAL T H+PLR +A++++ + + 
Sbjct: 86  KARMQAIGFEFPGQTEFYAARAKEENFAMCLTGGALTVALVTAHIPLRTVAESLSSSEII 145

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ---GMK 239
            V  +L   L  +    +PR+ V GLNPHAGE G +G EEI+ I P +  LR +     +
Sbjct: 146 RVGHLLADFLLLRLDR-KPRLAVAGLNPHAGESGALGREEIELIEPAVALLRGELGDTAE 204

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
             GP+  DT+F        D VL MYHDQGL  LK   F  GVN+TLGLPF RTS DHGT
Sbjct: 205 CIGPISPDTVFHRAAGGEFDGVLCMYHDQGLIPLKLHAFDSGVNVTLGLPFPRTSPDHGT 264

Query: 300 ALELAGRGKADVGSFITALNLAIKMI 325
           A E+AG+  A   S I A+NLA ++ 
Sbjct: 265 AFEIAGKDIARPDSMIAAINLAAELA 290


>UniRef50_A1VC56 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Desulfovibrio
           RepID=A1VC56_DESVV
          Length = 428

 Score =  328 bits (843), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 115/294 (39%), Positives = 156/294 (53%), Gaps = 8/294 (2%)

Query: 34  LVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVEN 93
           L + A+A+L  +           R  +P           L   P      V  G+  V  
Sbjct: 136 LCIGAEASLFAHTRK----AFWTRVDTPGDALAAGPGIYLYEPPGLDGLDVRVGEATVSG 191

Query: 94  GHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQ--AKKVVM 151
           G      L+ ACD    G    ++T P+HK +++ AG    GHTE+   R+     +V M
Sbjct: 192 GCAAGVALSAACDLLCAGVVPGVVTLPLHKAMLHTAGFDVPGHTEYLARRAGLADDEVCM 251

Query: 152 MLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPH 211
            L  + LRV+L TTH PLR++AD +T   +   + +    +R   G+  P + VCGLNPH
Sbjct: 252 HLCGDRLRVSLVTTHPPLREVADLVTRERVLRCLRLTAAFVRA-LGLQGP-VAVCGLNPH 309

Query: 212 AGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLP 271
           AGE G +G EEI+ I P + + R +G+ ++GP PADTLF         AVLAMYHDQGL 
Sbjct: 310 AGESGRIGREEIEVITPAIEDARREGLAVDGPFPADTLFHRAAGGGYPAVLAMYHDQGLG 369

Query: 272 VLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
            LK   F   VN+TLGLPF+RTSVDHGT  ++AG G+A  GSF  AL LA  + 
Sbjct: 370 PLKLLHFSDAVNVTLGLPFVRTSVDHGTGFDIAGTGRASTGSFTAALQLACMLC 423


>UniRef50_A1TTF8 4-hydroxythreonine-4-phosphate dehydrogenase n=10
           Tax=Burkholderiales RepID=A1TTF8_ACIAC
          Length = 374

 Score =  327 bits (839), Expect = 3e-88,   Method: Composition-based stats.
 Identities = 123/339 (36%), Positives = 170/339 (50%), Gaps = 21/339 (6%)

Query: 7   VVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLP----LTLRPYS 60
           + +T G+PAGIGP+++ +  +   +      V      L   A  +  P    L L    
Sbjct: 28  LAVTQGDPAGIGPEIIAKAFRDAPDAMRGCFVVGGVETLRRAARCIARPGEPSLPLALLQ 87

Query: 61  PNSPAQPQTAGTLTLLPVALRA-PVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
               A+      + LLP+      +  G +  E G    + +  A    L GE A L+T 
Sbjct: 88  APEEARAVPPRCVPLLPLPGLPGSIPFGAVHAEGGRAAADCVTWAARAALRGEIAGLVTA 147

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAK--------KVVMMLATEELRVALATTHLPLRD 171
           P+HK  ++ AG+   GHTE  +  +            V MMLA++ELR  L + H+ LR+
Sbjct: 148 PLHKEALSAAGVHHPGHTELLQAEAARHAGVPVADMPVRMMLASDELRTVLVSIHVSLRE 207

Query: 172 IADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLN 231
              A+T   +   + I H  LR   G   PRI V GLNPHAGEGG  G EEI+ I P + 
Sbjct: 208 AIAAVTQDNVLRTLEITHAALRRGLGRG-PRIGVAGLNPHAGEGGLFGREEIEAIAPAIA 266

Query: 232 ELRAQGMKLNGPLPADTLFQPKYL-----DNADAVLAMYHDQGLPVLKYQGFGRGVNITL 286
             RA G+  +GP   DT+F             D VLAMYHDQGL  +KY G  +GVN+TL
Sbjct: 267 AARALGIDAHGPFAPDTVFMRARSTPQRPGEFDVVLAMYHDQGLIPVKYLGVDKGVNVTL 326

Query: 287 GLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
           GLP +RTS DHGTA ++AGRG AD  S + A+  A ++ 
Sbjct: 327 GLPLVRTSPDHGTAFDIAGRGVADASSLVEAVLAARRLA 365


>UniRef50_Q7MAP7 PDXA HOMOLOG n=1 Tax=Wolinella succinogenes RepID=Q7MAP7_WOLSU
          Length = 307

 Score =  327 bits (838), Expect = 5e-88,   Method: Composition-based stats.
 Identities = 103/327 (31%), Positives = 162/327 (49%), Gaps = 24/327 (7%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCA-DATLLTNRAAMLGLPLTLRPYSPNSP 64
           ++ ++ G+P GIG ++ ++          ++   D  +L   +  LG+ +          
Sbjct: 2   KIFVSIGDPNGIGLEIALRSHSGVKDWGEIIYGVDERVLFEASQRLGIEVPQ-------- 53

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
                   +   P+ L +P+  G ++ E G Y  E+  +  +    GE  A++T PVHK 
Sbjct: 54  -------DMECDPLGLESPIAPGVISKEAGRYSFESFKKGVERAKKGEVQAIVTLPVHKK 106

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
             + AGIP+ GHTE   E    ++ +MM+  E   +AL T HLPL ++   +    +   
Sbjct: 107 AWSLAGIPYAGHTEALREMMG-EEAIMMMGKEGFFIALYTDHLPLSEVPQRVHERGVEGF 165

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN-GP 243
           +  L H L      A     V GLNPHAG+ G +G EE      +    +A G +L  GP
Sbjct: 166 LRRLSHAL-----PAMKACGVLGLNPHAGDQGVLGKEEEGIKRAIERANQALGRELFFGP 220

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           L  D  F P +    D  +AMYHDQGL  LK   F   +N++LGLPF+RTSVDHGTA ++
Sbjct: 221 LVPDVAFIPSWRAKFDHYVAMYHDQGLIALKILYFEESINLSLGLPFVRTSVDHGTAFDI 280

Query: 304 AGR-GKADVGSFITALNLAIKMIVNTQ 329
           A R G   + S+  A+ +A+K+  + +
Sbjct: 281 AYRGGNPSLLSYQNAIKMALKLGSDKR 307


>UniRef50_A7HIW4 4-hydroxythreonine-4-phosphate dehydrogenase n=4
           Tax=Anaeromyxobacter RepID=A7HIW4_ANADF
          Length = 372

 Score =  326 bits (837), Expect = 6e-88,   Method: Composition-based stats.
 Identities = 119/328 (36%), Positives = 166/328 (50%), Gaps = 10/328 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQ-LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            R+ ++ G+P+G+G ++  + LA     +   V  DA +L    A  GLP  L      +
Sbjct: 42  PRIAVSLGDPSGVGAEVTAKALAALAGQLVPYVFGDARVLARELAGSGLPCVL----AGA 97

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
           P  P+  G L  +       V  G+     G   +  L  A +    G+  AL T PV K
Sbjct: 98  PLPPE--GALVAVTRLPAGAVRPGRPDPRAGAAQLAALEAAFEAIRRGDADALTTAPVSK 155

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             +  A   F GHTE+ E R    + VMMLA E+L+VAL T H+    +  A+TP  + E
Sbjct: 156 AQVARALPGFVGHTEWLEARCGVGRSVMMLAGEKLKVALVTNHVAFWKLRRALTPERIAE 215

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            +A+ H  LR   G+A PR+ +  LNPHAGE G  G EE   +   L+     G +  GP
Sbjct: 216 TLALTHRALREDLGLARPRLALAALNPHAGEEGAFGAEETTLLAGALSRAARAGARAQGP 275

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQG---FGRGVNITLGLPFIRTSVDHGTA 300
            PAD++F    L   DAV+A+YHDQGL  +K          VN+TLGLP +RTS DHG A
Sbjct: 276 FPADSVFFRAALGEFDAVVALYHDQGLIPVKLLDAVCADPAVNVTLGLPIVRTSPDHGVA 335

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNT 328
            ++AG G A+  S I AL LA ++    
Sbjct: 336 YDIAGHGVANPASMIAALKLAARIAAVR 363


>UniRef50_B5JFI3 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JFI3_9BACT
          Length = 303

 Score =  324 bits (832), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 110/324 (33%), Positives = 162/324 (50%), Gaps = 25/324 (7%)

Query: 5   QRVVITPGEPAGIGPDLVVQLA--QREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           +++ IT G+P+G+GP+L+      +     E VV  +   +                   
Sbjct: 2   RKIAITCGDPSGLGPELIENCLDTRDYGDAEFVVFGNGPWVER----------------- 44

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
                   GT+           T G    +     +  +  A   C++GE  A++TGP+ 
Sbjct: 45  ---LESDRGTIVSGVSLCERGFTPGIPEPDGARLAMAAMEAAAKACIDGECHAVVTGPIS 101

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K +  + G  F G TEFF +R   K   M    E L++ LAT H+PLR +A+++T  +  
Sbjct: 102 KSLCAEVGYTFPGQTEFFADRWGGK-PSMAFVGERLKLCLATWHIPLRQVAESLTEKVFK 160

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ-GMKLN 241
             +      L  + GIA+P+ILVCGLNPHAGE G +G EEI+   P +  LR Q   ++ 
Sbjct: 161 HGVRSAVQ-LGQRSGIAKPKILVCGLNPHAGESGLLGREEIELFNPWIESLRGQLTAEIE 219

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
             +P DT F      + D V+AMYHDQGL   K   F  GVN++LGL ++R S DHGT  
Sbjct: 220 DCVPGDTAFARAIKGDGDVVVAMYHDQGLAPFKAVDFDSGVNVSLGLKYLRVSPDHGTGF 279

Query: 302 ELAGRGKADVGSFITALNLAIKMI 325
           +LAG+G A+ GS   A+ LA  M+
Sbjct: 280 DLAGKGLANAGSMHHAIRLACNMV 303


>UniRef50_Q31DF6 4-hydroxythreonine-4-phosphate dehydrogenase n=8
           Tax=Prochlorococcus marinus RepID=Q31DF6_PROM9
          Length = 343

 Score =  322 bits (827), Expect = 9e-87,   Method: Composition-based stats.
 Identities = 101/342 (29%), Positives = 161/342 (47%), Gaps = 32/342 (9%)

Query: 6   RVVITPGEPAGIGPDLVVQLA---QREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           ++V++ G+ +GIGP+++++     +    ++ V+      L N          L+     
Sbjct: 11  KLVLSVGDESGIGPEIILKALYSNEIPENIDFVIVGSKKNLQNTYR------KLKSLGLE 64

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
           + A P+    +  L ++              G      L +A +       +AL+TGP+ 
Sbjct: 65  NLANPKNLN-IHDLEISSSDDSK-----ASYGDSSFNYLTKAIEIVKQYPNSALVTGPIC 118

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATE------ELRVALATTHLPLRDIADAI 176
           K   + AG  F+G TE   +    K V M+   +       L   LATTH+ L ++   +
Sbjct: 119 KKSWSLAGHYFSGQTEVLAKSCGVKNVGMLFTAKSPITGWRLNTLLATTHIALCEVPKKL 178

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           T  L+H  + +      T   + +P   V GLNPHAGE G +G EE D +   L      
Sbjct: 179 TTELIHSKLDLFKDFCSTY--VDKPSFKVSGLNPHAGEEGLLGNEEKDWLNDALIAWNEN 236

Query: 237 G--MKLNGPLPADT-------LFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLG 287
              +KL GPL  D+        ++ K  +  D +LAMYHDQGL  +K       VN+T+G
Sbjct: 237 NRDIKLLGPLSPDSCWNSSAKAWRNKDAEKHDGILAMYHDQGLIPMKVIALNYSVNMTIG 296

Query: 288 LPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           LPFIRTS DHGT  ++AG+G A+  S I A+  AI+M  +++
Sbjct: 297 LPFIRTSPDHGTGFDIAGKGIAESQSMIEAIITAIEMTKSSR 338


>UniRef50_C0A8L4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Opitutaceae
           bacterium TAV2 RepID=C0A8L4_9BACT
          Length = 360

 Score =  322 bits (826), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 121/354 (34%), Positives = 167/354 (47%), Gaps = 54/354 (15%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            +  T G+PAG+GP+++     +  +   ++ V      L +               P S
Sbjct: 23  PLAFTCGDPAGVGPEIIAAWLAQHPDEYRDVAVIGPRRWLDS--------------LPAS 68

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A+    G   +        VT GQ          + + RA  GCLNGEF+ ++TGP+ K
Sbjct: 69  IAKIVVGGNDFV--------VTPGQPTEAGAVIAWDAMERAAAGCLNGEFSGVVTGPISK 120

Query: 124 GVINDAGIPFTGHTEFFEERSQA---------------------------KKVVMMLATE 156
             +   G  + G TEFF +R ++                            + VM  A  
Sbjct: 121 AWLARVGYKYPGQTEFFADRWRSASTIGQGGGGDRGNGGSGGRNGGNGKNGQPVMAFAGG 180

Query: 157 ELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAE--PRILVCGLNPHAGE 214
            L V L T H+PLR +A  +T A     I     +L   +G     PRI VCGLNPHAGE
Sbjct: 181 RLPVGLHTWHIPLRAVAAELTLANFTRSIR-AADELARVYGCEREHPRIGVCGLNPHAGE 239

Query: 215 GGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLK 274
            G +G +E D I P+L+ LRAQ   L+   P DTLF  +     D V+A+YHDQGL  LK
Sbjct: 240 EGLLGNQERDVIDPILDTLRAQFHGLSRSEPGDTLFGRQLRGEFDVVVALYHDQGLAPLK 299

Query: 275 YQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
              F   VNITLGL  +RTS DHGTA  +AG+GKA + SF  A+ +A ++I   
Sbjct: 300 VIDFDESVNITLGLAHVRTSPDHGTAFGIAGQGKASIRSFANAVTVARRLIRAR 353


>UniRef50_Q17ZN0 4-hydroxythreonine-4-phosphate dehydrogenase n=16
           Tax=Epsilonproteobacteria RepID=PDXA_HELAH
          Length = 310

 Score =  322 bits (825), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 92/322 (28%), Positives = 158/322 (49%), Gaps = 19/322 (5%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
           MVK +++ I+ G+  GIG +L+++  +      E +    + LL     +L     ++P 
Sbjct: 1   MVK-KKIAISCGDIQGIGLELILKSHKEVSVLCEPLYLIHSELLGRANQLLTNAYEVKPL 59

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
           +  +             P+      T G+++ ++G Y  E+  +AC+   + E  ++ T 
Sbjct: 60  NAIAINS----------PLPSFNSSTIGKVSAQSGAYSFESFRKACELADDKEVDSICTM 109

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P++K     A IPF GHT+F ++R +  +++MML   +L V L + H+PLR ++  I   
Sbjct: 110 PINKLAWQQAQIPFVGHTDFLKQRYKEHQIIMMLGCPKLFVGLFSDHVPLRAVSQLIQVK 169

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            L + +       + +       I VCG NPHAGE G  G E+   +  +    +  G +
Sbjct: 170 ALVQFLLAFQKSTQAQI------IQVCGFNPHAGEEGLFGEEDEKILKAIQESNQTLGFE 223

Query: 240 LN-GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
              GPLPAD+ F P         ++M HD GL  LK   F   +N++L  P +R S DHG
Sbjct: 224 CFLGPLPADSAFAPNKRQITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHG 283

Query: 299 TALELAGRGKADVGSFITALNL 320
           TA ++A + KA+  S++ A+  
Sbjct: 284 TAFDIAYQNKANNKSYLNAIKY 305


>UniRef50_C9PYW4 Pyridoxal phosphate biosynthetic protein PdxA n=1 Tax=Prevotella
           sp. oral taxon 472 str. F0295 RepID=C9PYW4_9BACT
          Length = 371

 Score =  318 bits (816), Expect = 1e-85,   Method: Composition-based stats.
 Identities = 90/331 (27%), Positives = 141/331 (42%), Gaps = 8/331 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPY 59
              R+ IT G+  GIG +L+ +        EL   +V     +       L L +     
Sbjct: 4   NKLRIAITQGDANGIGMELIFKTFASPEMFELCTPIVYGSPKVAAYHKKALNLDVNFSII 63

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
              + A+P+    L +        +  G    +      + + RA   C  G   A++  
Sbjct: 64  QDGAEAKPERLNLLAIADED--VKIEFGTPNEDAATLARKAIDRAVADCKAGVVGAIVNA 121

Query: 120 PVH-KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           P+  K        P +      ++  +  +V+ M   E LR+   +  L ++D+A+ IT 
Sbjct: 122 PISEKHFFTTQEQPVSLSQYIAKQLGETNEVLEMSLNECLRITTLSGELAIKDVANEITK 181

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             +   + +LHH LR  F I+ PR+ V  LNP   +G     EE + I P + +L A G 
Sbjct: 182 ERIESAVRLLHHSLRRDFMISIPRVAVLALNPTLEDGP--CKEEQEVIAPAVKQLIADGY 239

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
              GP  AD+ F  +  D  DAVLAMYHDQ +   K      GV   +GL  + TS D  
Sbjct: 240 MAFGPYQADSFFGDREFDTFDAVLAMYHDQAMIPFKALSCEGGVRFIIGLSAVITSTDDE 299

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNTQ 329
                AG+G AD  +F  A+ LA+ +  N +
Sbjct: 300 ALDGKAGQGVADEIAFRHAIYLALDVSRNRK 330


>UniRef50_C3XMM1 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Helicobacter
           RepID=C3XMM1_9HELI
          Length = 317

 Score =  318 bits (815), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 106/333 (31%), Positives = 165/333 (49%), Gaps = 37/333 (11%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWP-VELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           ++ ++ G+P G+G +++++  ++       V C D  LL   A +L   L          
Sbjct: 2   KIAVSIGDPNGVGLEILLKNHKKICKFCNPVYCVDKELLKEAAKILKFKLPKN------- 54

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
                  +  ++P  +   +T G +  E+G Y   +  +A +  L G+  A++T P+HK 
Sbjct: 55  ---LKCVSPKVMPSNIIPKITPGAIQKESGAYSYASFLQALNLTLVGKTKAMVTLPIHKK 111

Query: 125 VINDAGIPFTGHTEFFEERS------------QAKKVVMMLATEELRVALATTHLPLRDI 172
               AG+ + GHTE   +              Q +K +MML + +L VAL + H+PL+++
Sbjct: 112 AWQLAGVSYAGHTEALRDVFKFENMESKINGIQNQKAIMMLGSPKLYVALFSDHIPLKNV 171

Query: 173 ADAITPALLHEVIAILH-HDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLN 231
              I    L E +     + L+   G       V GLNPHAG+ G +G E+ + I   + 
Sbjct: 172 PSLINIESLKEFLLDFAPYVLKMPCG-------VLGLNPHAGDFGVLGDED-NVIREAIR 223

Query: 232 ELRAQ-GMKLN-GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLP 289
              A  G ++  GPL  DT F  K+L      +AMYHDQGL  LK   F   +NITL LP
Sbjct: 224 LANASLGKEVFIGPLVPDTAFVGKHLRYY---VAMYHDQGLIPLKTLYFKESINITLNLP 280

Query: 290 FIRTSVDHGTALELAGRGKADVGSFITALNLAI 322
            IRTSVDHGTA ++A + KA+  S+I A+  AI
Sbjct: 281 VIRTSVDHGTAFDIAYKNKAESKSYINAIKEAI 313


>UniRef50_B6BUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=beta
           proteobacterium KB13 RepID=B6BUU4_9PROT
          Length = 310

 Score =  318 bits (815), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 110/333 (33%), Positives = 170/333 (51%), Gaps = 30/333 (9%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLP----LTL 56
           M   + + ++ G+P GIG DL   L ++     + +  D   L +RA +LG+       +
Sbjct: 1   MNHIKTLAVSAGDPDGIGYDLCALLFKKNLNYHVDIYGDKEALLSRAKLLGIKNLHNEKI 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
           + Y   +  Q +    L                       V+E++  A   C+  +  AL
Sbjct: 61  KIYDVKNNKQIKNKREL-----------------------VLESIKSATKSCIQKKSIAL 97

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAK-KVVM-MLATEELRVALATTHLPLRDIAD 174
           +T PV+K  ++ +   FTGHTE+  E  +A+ + +M  +  +++ VA  TTH+ L +   
Sbjct: 98  VTLPVNKEKLSTSKNLFTGHTEYIAELLKARNEPIMTFIGNKKIIVATNTTHMSLLNAIK 157

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +    L   + +LH  ++ +  I  P+ILV GLNPHAGE    G EE   IIP +N+L+
Sbjct: 158 NVEKNNLINKLQLLHSCIKNQLKIKYPKILVTGLNPHAGENNLFGNEESKHIIPAINKLK 217

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
              + L+GP+PADT      +   D +  MYHDQ L   K   F  GVN+TLGLP IRTS
Sbjct: 218 ELDIHLDGPVPADTALLKNNMRKYDCIYYMYHDQALCAFKTLFFDTGVNLTLGLPIIRTS 277

Query: 295 VDHGTALELAGRG-KADVGSFITALNLAIKMIV 326
           VDHGTA EL G+  +  + SF+ AL++A K+  
Sbjct: 278 VDHGTAEELVGKKERISIKSFLNALDIAEKLSH 310


>UniRef50_B2UL26 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Akkermansia
           muciniphila ATCC BAA-835 RepID=B2UL26_AKKM8
          Length = 289

 Score =  318 bits (815), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 104/327 (31%), Positives = 143/327 (43%), Gaps = 41/327 (12%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
              +  T G+ +GIGP+++                                         
Sbjct: 2   KPVIGYTLGDQSGIGPEVISAALASG------------------------------ELPE 31

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A+ +  G         R  +  G+   E+  +  + L +A      G   A++T PV K
Sbjct: 32  DAEYRLIGK--------RVELPPGRPNAESAKHAFDHLEQAAHALREGTVDAVVTAPVCK 83

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             +++AG  + G TEFF ER +     M L  + L V LAT H  L+ +   +    L  
Sbjct: 84  ETLHEAGFRWPGQTEFFAERLKTDNYAMCLTGKRLTVGLATIHTSLQSVPSLLETEELVR 143

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA--QGMKLN 241
           +  +L      K GI  PRI +  LNPHAGE G  G E+ + I P +  LRA       +
Sbjct: 144 IGTLLKDFCIRK-GIMRPRIALAALNPHAGEHGAFGDEDGNIIAPAVERLRAIHPDAAFD 202

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP   D +++     N DAVLA YHDQGL  LK   F   VN+TLGLP  R S DHGTA 
Sbjct: 203 GPSVPDCVYRDAVEGNYDAVLAPYHDQGLIPLKLVDFHTAVNVTLGLPRPRLSPDHGTAF 262

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNT 328
            LAG GKA+  S I A  LA++M    
Sbjct: 263 NLAGTGKANPSSTIHAFQLAVQMARRR 289


>UniRef50_B3DY74 Pyridoxal phosphate biosynthesis protein n=1 Tax=Methylacidiphilum
           infernorum V4 RepID=B3DY74_METI4
          Length = 294

 Score =  317 bits (813), Expect = 4e-85,   Method: Composition-based stats.
 Identities = 108/326 (33%), Positives = 161/326 (49%), Gaps = 40/326 (12%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           ++   + IT GEPAGIGP++V +  +                                  
Sbjct: 1   MRIPTIGITLGEPAGIGPEIVAKALKSNQI------------------------------ 30

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
                           +  +A   AG+L+  +     E L  A       E  A++T P+
Sbjct: 31  --------PKRFDYKVIGPKAKFEAGKLSSSSAAAAWEALEEAYKLWEKKEIQAIVTSPI 82

Query: 122 HKGVINDAGIPFTGHTEFFEERSQA--KKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           HK  +   G P+ G TEFF  ++     KV+M +++ ++ ++L +TH+ L     +IT  
Sbjct: 83  HKDNLFQIGFPYPGQTEFFAAKAGVPRDKVIMAMSSPKINLSLLSTHVSLYQAIKSITKD 142

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +     +L   L+     +   I + GLNPH GEGG+ G EE +T IP +NELR Q + 
Sbjct: 143 KIKLASVLLLEFLKKIKKKSNLTIAISGLNPHCGEGGNFGNEENETFIPAINELRNQELP 202

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           ++GP+  D++F+   L   D V+A YHDQGL   K   F  GVN+TLGLP IRTS DHG 
Sbjct: 203 VHGPVSPDSVFREVLLGKYDGVVASYHDQGLIPFKLVSFYSGVNVTLGLPLIRTSPDHGV 262

Query: 300 ALELAGRGKADVGSFITALNLAIKMI 325
           AL++AG+ KAD  S I+A+ LA K+I
Sbjct: 263 ALDIAGQNKADPRSLISAIKLACKLI 288


>UniRef50_C1A9L0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Gemmatimonas
           aurantiaca T-27 RepID=C1A9L0_GEMAT
          Length = 309

 Score =  317 bits (812), Expect = 5e-85,   Method: Composition-based stats.
 Identities = 109/322 (33%), Positives = 158/322 (49%), Gaps = 29/322 (9%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           + IT G+P GIGP++V +  +        + A   ++      + + + L P+ P+  AQ
Sbjct: 12  LGITLGDPRGIGPEIVGKALRDSRVE--ALGAFWQVIGPSGTGVPVDVDLGPWQPSGDAQ 69

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
                                      G      + RA      G    ++T P+ K  +
Sbjct: 70  ADL---------------------ATGGRLAGLAVERATAMAQRGTIDGMVTAPLDKAAL 108

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIA 186
              G  + GHTE     +      MMLA++ LRV LATTH+ LRD+  ++T A + +   
Sbjct: 109 KAGGYDYPGHTEMLAALTGV-PTTMMLASDRLRVVLATTHIALRDVPVSLTAAAIRQAAQ 167

Query: 187 ILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPA 246
                LR   GI  PRI++C LNPHAG+ G  G E+   + P+  EL      L+GPLPA
Sbjct: 168 ATEAGLRADLGIPVPRIVLCALNPHAGDHGRFGDEDDTLLAPLAREL-----GLHGPLPA 222

Query: 247 DTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGR 306
           DT+F        DAV+A YHD G+  +K   FG  VNITLGLPF+RTS DHGTA+++AG+
Sbjct: 223 DTVFVRALRGEFDAVIAPYHDVGMTAIKVASFGSAVNITLGLPFVRTSPDHGTAIDIAGQ 282

Query: 307 GKADVGSFITALNLAIKMIVNT 328
           G A   S I A+  A+ ++   
Sbjct: 283 GVASAESLIQAMTTAVGLVRRR 304


>UniRef50_Q04UJ6 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Leptospira
           RepID=Q04UJ6_LEPBJ
          Length = 316

 Score =  313 bits (804), Expect = 4e-84,   Method: Composition-based stats.
 Identities = 105/323 (32%), Positives = 162/323 (50%), Gaps = 22/323 (6%)

Query: 5   QRVVITPGEPAGIGPDLVVQ---LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           +R++IT G+P GIGP++ V    L ++   +  +V   +            PL     S 
Sbjct: 2   KRILITEGDPCGIGPEIFVHSLFLLRKISKIRPIVYFHSG---------KFPLPKEFVSI 52

Query: 62  NSPAQPQTAGTLTL----LPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
           +S ++    G   +    L     + +  G+ +  +G   +  L  + +    G    LI
Sbjct: 53  SSSSEILKKGLFAIGHDSLSKKEVSSLKFGRPSALSGKSALAALVLSIEFQKEGGGD-LI 111

Query: 118 TGPVHKGVINDAGIP-FTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
           T P+ K  +  +G+  F GHTEF  E  + K   M+++  +L+V   TTH+PL  + + +
Sbjct: 112 TLPLSKEWVIASGVSTFRGHTEFLAEAYRTKTF-MLMSGNDLQVLPLTTHIPLVKVPEFL 170

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
               L  +   +    +         I   GLNPHAGEGG +G EE + ++P++  L+ Q
Sbjct: 171 KEIDLKSLANSILSCEKIDLQKP---IAFLGLNPHAGEGGKIGKEEEEILVPMIRSLKRQ 227

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G+K+ GPL AD++F           LA YHDQGL   K     +GVN+TLGLPFIR S D
Sbjct: 228 GLKVEGPLSADSVFGESARKKFGLHLACYHDQGLIPFKMWEGKKGVNLTLGLPFIRVSPD 287

Query: 297 HGTALELAGRGKADVGSFITALN 319
           HGTA ++AG+G AD  SF+  LN
Sbjct: 288 HGTAFDIAGKGLADSTSFMECLN 310


>UniRef50_A5GHP5 4-hydroxythreonine-4-phosphate dehydrogenase n=11 Tax=Cyanobacteria
           RepID=A5GHP5_SYNPW
          Length = 342

 Score =  310 bits (795), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 111/337 (32%), Positives = 163/337 (48%), Gaps = 22/337 (6%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            Q +VI  G+PAGIG ++ ++        E +      L+  RA++      LR  +   
Sbjct: 11  NQHLVIALGDPAGIGMEVTLKALAHPRCPEGM---KPLLVGCRASLKRTHQRLRNLTGVP 67

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A P     +  LP+   APV  G      G      L+RA +    G   AL+T P+ K
Sbjct: 68  LADPDDL-DVEDLPIP-GAPVNPGDAGAAGGAAGFRWLSRAVELVQAGHGRALVTAPIAK 125

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLA------TEELRVALATTHLPLRDIADAIT 177
              + AG P+ G TE   E  +A+   M+           L   LATTH+PL+ ++ A+T
Sbjct: 126 HTWHAAGHPYPGQTERLAELDRAESASMLFTAVSPSTGWRLNTLLATTHIPLQQVSQALT 185

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
           PAL+   +  L    +       P +LV GLNPHAGE G +G+EE   + P+L++     
Sbjct: 186 PALVRSKLETLTRFCQRFN--PSPELLVAGLNPHAGEKGQLGSEEEQWLTPLLHQWAQAN 243

Query: 238 --MKLNGPLPADTLFQPKYLD-------NADAVLAMYHDQGLPVLKYQGFGRGVNITLGL 288
             ++L GPLP DT +               D +LA+YHDQGL  +K   F + VN TLGL
Sbjct: 244 PTIRLKGPLPPDTCWLSAAQAWNRSDASGPDGILALYHDQGLIPVKLLAFDQAVNTTLGL 303

Query: 289 PFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
            F+RTS DHGT  ++A +G A   S ++A+  A  + 
Sbjct: 304 SFLRTSPDHGTGFDIAAQGIARCESMLSAIEAAWTLS 340


>UniRef50_A9GKN1 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Sorangium
           cellulosum 'So ce 56' RepID=A9GKN1_SORC5
          Length = 326

 Score =  309 bits (793), Expect = 8e-83,   Method: Composition-based stats.
 Identities = 113/314 (35%), Positives = 154/314 (49%), Gaps = 14/314 (4%)

Query: 18  GPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLT-LRPYSPNSPAQPQTAGTLTLL 76
           GP++ V  A        V+  D  +    A ++ +    L      +  +    G + L 
Sbjct: 2   GPEVAVAGAASVEGARCVLVGDEAITRRAARLVRVAARRLVVVDGRAAIEELAPGAIGLW 61

Query: 77  PVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIP-- 132
             +  L  P   G+   E+G   +  +  A D    G  AAL+TGP  K  I  +G P  
Sbjct: 62  AGSARLSRPSAFGRPEAEDGAAQLAWIDAATDLVREGVAAALVTGPASKHAIATSGAPGS 121

Query: 133 --FTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHH 190
             F GHTE    R +A++V M  A+ +L  AL TTH+PLR++ DA++P  +    A+   
Sbjct: 122 ADFLGHTEHLGRRLRAREVTMAFASGKLVTALVTTHVPLREVPDAVSPREVARA-AVWLA 180

Query: 191 DLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIP----VLNELRAQG--MKLNGPL 244
            L    G   PR+ V  LNPHAGEGG +G EE   I P        L   G   +L GP+
Sbjct: 181 RLLGDLGRERPRVAVAALNPHAGEGGLLGDEEQVRITPGIRLAARRLSRSGPAAELTGPV 240

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELA 304
            A+T F+       D V+AMYHDQ     K  GFG  VN+TLGLP +RTSVDHGTA +LA
Sbjct: 241 GAETAFRLAARGALDGVVAMYHDQATIPSKLLGFGEAVNVTLGLPIVRTSVDHGTAYDLA 300

Query: 305 GRGKADVGSFITAL 318
           G G+AD      A+
Sbjct: 301 GTGRADPRGMREAI 314


>UniRef50_A9LFJ9 Pyridoxal phosphate biosynthetic protein (Fragment) n=1 Tax=Karenia
           brevis RepID=A9LFJ9_KARBR
          Length = 254

 Score =  309 bits (792), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 90/247 (36%), Positives = 130/247 (52%), Gaps = 4/247 (1%)

Query: 83  PVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGI-PFTGHTEFFE 141
            +   ++ V+ G      +  A    +      ++T P++K  + +AG   + GHTE  +
Sbjct: 7   KMPFERVQVKAGRCATLWVREATRLAVEKRIDGIVTAPLNKQAMYEAGFTQYGGHTEILQ 66

Query: 142 ERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEP 201
           E S AK   + L ++   VA  T H+P R+I+D + P  + E   IL   L+    + EP
Sbjct: 67  EGSGAKSSSLCLYSDGFTVAHVTCHIPFREISDRLNPQKVFETTRILRDFLKMIHPMKEP 126

Query: 202 RILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG-PLPADTLFQPKYLDNADA 260
           RI++ GLNPH       G EEI  I P +++  A G  ++  P+P DT+F        DA
Sbjct: 127 RIVMAGLNPHC--EPIFGDEEIRCIQPAIDDALALGWNVHRVPVPPDTVFLRTQRGEWDA 184

Query: 261 VLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNL 320
           V+AMYHDQG    K  GF   VN+TLGLP IRTSVDHGTA  +AG G AD  +  +A++L
Sbjct: 185 VVAMYHDQGHIPAKMGGFSNTVNVTLGLPIIRTSVDHGTAFNIAGTGTADESNLFSAIHL 244

Query: 321 AIKMIVN 327
              M   
Sbjct: 245 CTTMANG 251


>UniRef50_Q0C095 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Alphaproteobacteria RepID=Q0C095_HYPNA
          Length = 335

 Score =  308 bits (789), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 112/330 (33%), Positives = 150/330 (45%), Gaps = 16/330 (4%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQ---REWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
            + +T G+PAG GP +                 V     L                 +  
Sbjct: 8   PLALTMGDPAGCGPQITAAAWHALKDNPASAFYVVGWPGLYCGA--------PTEVIASP 59

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
             A    +  L +L      PVT G+   +    ++ ++  A    L G   A++T P+H
Sbjct: 60  GDAARVFSRALPVLARGDARPVTPGKPDPDTAAGIITSIETATAHALAGIAGAVVTNPIH 119

Query: 123 KGVINDAGIPFTGHTEFFEERSQAK-----KVVMMLATEELRVALATTHLPLRDIADAIT 177
           K ++   G  F GHTEF             + VMML    LRVALAT H+P   +  A+ 
Sbjct: 120 KALLYGQGFRFPGHTEFIASLCATDGGAAPEPVMMLTGGGLRVALATIHMPYTAVPAALA 179

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              L  +  I    L  +FGI  PRI   GLNPHAGE G +G EE++ I P   ELR +G
Sbjct: 180 DGRLQRIARITAAALTRQFGIPAPRIAFTGLNPHAGEDGTIGREEVEIINPAAAELRNEG 239

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           + ++   P DT+F        DAV+AM HDQGL  +K      GVN TLGLP IRTS DH
Sbjct: 240 LDISDARPGDTVFAEALGGRFDAVIAMTHDQGLIPVKTLDMWGGVNTTLGLPIIRTSPDH 299

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVN 327
           GTA + A  G A   S I A++ A +   N
Sbjct: 300 GTAYDAAAAGTAKADSLIAAIHSAREQAAN 329


>UniRef50_Q4FMQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Candidatus
           Pelagibacter RepID=Q4FMQ9_PELUB
          Length = 320

 Score =  303 bits (776), Expect = 6e-81,   Method: Composition-based stats.
 Identities = 94/321 (29%), Positives = 148/321 (46%), Gaps = 6/321 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQ-LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           +  + ++I  GEP  I  ++  + L    +   L++     LL  +   L     +    
Sbjct: 1   MGKEPIIIVGGEPNSIFLEIFFKSLKTNIYKSPLIIIISKKLLQEQMKKLDFYFKINDID 60

Query: 61  PN-SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
                    T   + L+ V  +      ++  ++  Y+ ET   A +       +  I G
Sbjct: 61  KELKDFSKLTNKKINLINVDYKFKKCFEKITSKSNKYIDETFKVALNFMKQNNLSKFING 120

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           PV K           G TE+  ++++ K V M++  + L V+  TTHL L+D+   IT  
Sbjct: 121 PVSKKSFLKG--KTLGITEYLAKKTKKKDVAMLIFNKNLSVSPLTTHLALKDVHKKITKQ 178

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            ++  + +++   +TKF    PRI + GLNPH  E     +EE   IIP + +LR +  K
Sbjct: 179 KIYTQVNLINKFYKTKFN-KLPRIAITGLNPHC-ESNFQNSEEDKVIIPAIKKLRLKNNK 236

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           +NGP PADT+F    L   D ++ MYHDQ L  +K       +NITLGLPF R S DHG 
Sbjct: 237 INGPFPADTIFTKFLLKKYDVIIGMYHDQVLSPMKALFGFDAINITLGLPFTRISPDHGP 296

Query: 300 ALELAGRGKADVGSFITALNL 320
              + G+  +D  S I AL  
Sbjct: 297 NYSMLGKNLSDPKSLIQALKF 317


>UniRef50_C5T2H3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Burkholderiales RepID=C5T2H3_ACIDE
          Length = 230

 Score =  302 bits (775), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 103/230 (44%), Positives = 141/230 (61%), Gaps = 14/230 (6%)

Query: 109 LNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAK--------KVVMMLATEELRV 160
           + G+ AAL+T P+HK  ++ AG+ F GHTE  +  + A          V MMLA++ELR 
Sbjct: 1   MRGDIAALVTAPLHKEALSAAGVDFPGHTELLQAEAAAHQGVPLADMPVRMMLASDELRT 60

Query: 161 ALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT 220
            L + H+ LRD  DA+T   + + + I H  L    G A PR+ V GLNPH GEGG  G 
Sbjct: 61  VLVSIHVSLRDAIDAVTRDNVLQTLRITHAALLRSLGRA-PRMAVAGLNPHGGEGGLFGR 119

Query: 221 EEIDTIIPVLNELRAQGMKLNGPLPADTLF-----QPKYLDNADAVLAMYHDQGLPVLKY 275
           EEI+ I+P + + RA GM ++GP   DT+F      P+     D VLAMYHDQGL  +KY
Sbjct: 120 EEIEHIVPAVADARALGMDVHGPFAPDTVFMRARHTPQRAGEFDVVLAMYHDQGLIPVKY 179

Query: 276 QGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
            G  +GVN+TLGLP +RTS DHGTA ++AG+G AD  S + A+ +A ++ 
Sbjct: 180 LGVDKGVNVTLGLPLVRTSPDHGTAFDIAGQGVADAASLVEAVRVARQLA 229


>UniRef50_D0E8J8 Pyridoxal phosphate biosynthesis protein n=1 Tax=uncultured
           bacterium HF130_AEPn_1 RepID=D0E8J8_9BACT
          Length = 304

 Score =  302 bits (774), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 97/334 (29%), Positives = 151/334 (45%), Gaps = 35/334 (10%)

Query: 1   MVKTQ-RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
           M   + +++I  GE   IGP++  +                  L +++++         Y
Sbjct: 1   MTDNRMKIIICSGEKDSIGPEVTEKALLS--------------LYDKSSLRLNEFKFEIY 46

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
            P      +  G   L           G          ++ +  A +  L+G+  A++TG
Sbjct: 47  GPKEKFSKRALGLFEL--------SEPGN--------ALDFVREAVEQQLSGKAHAMVTG 90

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           P+ K         F GHT +  +      + +M     ++ V+  T HLP +++ ++I  
Sbjct: 91  PIDKLRWAKVLPGFLGHTGYLGQLCGHEDEPLMAFVGGKMIVSPLTIHLPFKEVPNSINI 150

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG- 237
             L + I +    L       + R+ VCGLNPHA + G MG EE   I P +  ++ +  
Sbjct: 151 DFLEKKIFLCVKLLEDIKKSKKVRLAVCGLNPHASDKGLMGDEEEKFISPAIKLVQDKFP 210

Query: 238 -MKLNGPLPADTLFQPKYL-DNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
             ++ GPLP DT F   ++ D  D V A+YHDQ L   K   F  GVNIT GLP IRTSV
Sbjct: 211 EAEITGPLPGDTAFFKAFMEDEHDMVAAIYHDQALAPFKLLHFYDGVNITYGLPIIRTSV 270

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           DHGTA ELAG+G AD  S   A+  A+++    +
Sbjct: 271 DHGTAYELAGKGAADHRSMENAILWAMRLASQKK 304


>UniRef50_UPI00019786BC 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Helicobacter
           cinaedi CCUG 18818 RepID=UPI00019786BC
          Length = 312

 Score =  298 bits (764), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 89/323 (27%), Positives = 147/323 (45%), Gaps = 24/323 (7%)

Query: 5   QRVVITPGEPAGIGPDLVVQLA-QREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            ++ I+ G+  GIG ++ ++         E V      ++ + A +LGL +  +     +
Sbjct: 2   PKIAISIGDINGIGLEIALKSHNAISQICEPVYVTHLEIVESAAKILGLSMP-KDMKCVA 60

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
             +             L   +  G ++ E+G Y  ++  +A     +    AL+T P+HK
Sbjct: 61  DFE-------------LCVDIQPGVVSKESGLYSYKSFLQAIKLTESRITQALVTLPIHK 107

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
               +AG+   GHT+   +   A   +MML  EE+ VAL T H+PLR ++ +I    +  
Sbjct: 108 KAWQEAGVKSIGHTQVLSQYFGA-DSIMMLGCEEMFVALYTDHIPLRKVSQSINQDSIKT 166

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN-G 242
            +      +R    + EP   V GLNPH G+GG MG E+      V         +L  G
Sbjct: 167 FLLSFAGAVR----LNEP-CCVLGLNPHCGDGGLMGDEDKYITQAVCEANMVLNRELFFG 221

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
             P D+ F P         ++ YHD GL  LK   F + +N++L LP +RTSVDHG   +
Sbjct: 222 AYPPDSAFSPLNRKKFRYFVSQYHDVGLAPLKALYFEQSINVSLNLPILRTSVDHGVGFD 281

Query: 303 LAGRG--KADVGSFITALNLAIK 323
           +A +   K    S++ A+  A+ 
Sbjct: 282 VAYKKSVKIHTQSYMNAVKYAVD 304


>UniRef50_Q3V7R5 Pyridoxal phosphate biosynthetic protein n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q3V7R5_BDEBA
          Length = 316

 Score =  295 bits (757), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 99/329 (30%), Positives = 156/329 (47%), Gaps = 18/329 (5%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGL-PLTLRPYS 60
           +   R+ +T G+  GIG ++  +      P + V        +     L L        +
Sbjct: 1   MSKLRIALTTGDVDGIGFEVTAKALHHLGPQKGVQFLLWRPDSASQKYLKLIDQKFERIT 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            +  +Q        L+ +              +     + +  +   CL  E  AL T P
Sbjct: 61  VDDLSQALEIEGPYLIDI-------------ASDLAPAKWVELSAKACLKKEIHALATAP 107

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           + K  I  AG    GHT+  +  S AK V M    E+  V LAT HLP+++I   ++ ++
Sbjct: 108 LSKTSIKAAGFKDLGHTDILKRLSGAKHVHMGFVGEKFNVVLATAHLPVKEITKHLSFSV 167

Query: 181 LHEVIAILHHDLRTKFGIAEPR--ILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
           L E + +  ++LR K   ++ +  I V GLNPHAGE G +G EE+     +++  + + +
Sbjct: 168 LAEAL-LNANELRKKLPASQAKKPIGVLGLNPHAGEAGLIGQEELLFFPELVSFAKEKKI 226

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQ-GFGRGVNITLGLPFIRTSVDH 297
              GPL  D  F P+        L++YHDQGL   K   G   GV++TLG+PFIRTSVDH
Sbjct: 227 PFEGPLVPDAAFFPQNWKKYSVYLSLYHDQGLIPFKMIHGQDSGVHMTLGIPFIRTSVDH 286

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIV 326
           GTA ++ G+ KA+  S I A+  A+K+  
Sbjct: 287 GTAKDIFGKNKANPHSMIDAVRWAVKLAR 315


>UniRef50_Q0RWE6 Terephthalate dihydrodiol dehydrogenase n=2 Tax=Bacteria
           RepID=Q0RWE6_RHOSR
          Length = 338

 Score =  290 bits (743), Expect = 5e-77,   Method: Composition-based stats.
 Identities = 107/325 (32%), Positives = 151/325 (46%), Gaps = 15/325 (4%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQL---AQREWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
              RV++T G+P GIGP+L V+    AQ       V+  D  ++   A   G+ +     
Sbjct: 4   SPPRVLLTIGDPNGIGPELAVKAVMAAQEHPAFNPVLVGDRCVVEPLAHRAGMTVR---E 60

Query: 60  SPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
           + +  A P  A  + LLPV          G++  E G   V  L RA      G    ++
Sbjct: 61  TADGLATPM-ADVVDLLPVPSLPAGAFAPGRVTAEAGKATVAYLERAVRCLQGGGARGIV 119

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQA--KKVVMMLATEELRVALATTHLPLRDIADA 175
             P  +  +N AGI F G+     E   A   +V +ML    LR+  AT H  LRD    
Sbjct: 120 ACPHSETAVNAAGISFDGYPSLLAELVGARPDQVFLMLIGAGLRIVHATLHESLRDALGR 179

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           +TP L+H         L+ + GI  PRI V G+NPHAGEGG  G E++    P +  LRA
Sbjct: 180 LTPELVHGAARAAVETLQAQ-GIPSPRIGVFGINPHAGEGGLFGDEDLRVTTPAVERLRA 238

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
            G+  +GP+ AD           DA +AMYHDQG   +K         +T+G     +SV
Sbjct: 239 AGIDASGPVGAD---LMLADPGFDAFVAMYHDQGHIPVKLLAGRSAAAMTIGAGVRFSSV 295

Query: 296 DHGTALELAGRGKADVGSFITALNL 320
            HG   ++AG+G AD  + + AL L
Sbjct: 296 GHGAGFDIAGKGTADPDAVVGALRL 320


>UniRef50_Q5HTM4 4-hydroxythreonine-4-phosphate dehydrogenase n=15 Tax=Campylobacter
           RepID=PDXA_CAMJR
          Length = 364

 Score =  290 bits (742), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 92/366 (25%), Positives = 152/366 (41%), Gaps = 53/366 (14%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPL--------- 54
           +++ I+ G+  GIG +++V+  +              +LL   + +L L L         
Sbjct: 2   KKLAISIGDINGIGLEILVRSHEELSKICTPFYFIHESLLDKASKLLNLKLFNAKIVAFK 61

Query: 55  -----TLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCL 109
                        +  +  +        V     + AG++  ++G Y   +   A     
Sbjct: 62  DGKDYEFNFVKKENSLEIYSFYLPLDFKVDENFEIKAGEIDTKSGLYGFLSFKAASYFVY 121

Query: 110 NGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPL 169
                AL+T P+HK    DAG+ + GHT+   +  + K  +MML  +EL V L + H+PL
Sbjct: 122 EKHAHALLTLPIHKKAWEDAGLKYKGHTDALRDFFK-KNAIMMLGCKELFVGLFSEHIPL 180

Query: 170 RDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPV 229
             ++  IT   L   +   + +   K      ++ + G NPHAG+ G +G EE   +   
Sbjct: 181 AKVSKKITFKNLSIFLKDFYKETHFK------KMGLLGFNPHAGDYGVIGGEEEKIMEKA 234

Query: 230 LN------------------------------ELRAQGMKLNGPLPADTLFQPKYLDNAD 259
           +                                 + +G+ L  PL ADT F    L N +
Sbjct: 235 IAFVNAFLHSKKDEKFFKKALKDENLQKELLLNFKGKGVYLPHPLVADTAFTKTGLKNCN 294

Query: 260 AVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRG-KADVGSFITAL 318
            ++AMYHD  L  LK   F + +N++L LP IR SVDHGTA + A +  K +  S+  A 
Sbjct: 295 RLVAMYHDLALAPLKALYFDKSINVSLNLPIIRVSVDHGTAFDKAYKNAKINTKSYFEAA 354

Query: 319 NLAIKM 324
             AI +
Sbjct: 355 KFAINL 360


>UniRef50_A1RD08 Pyridoxal phosphate biosynthetic protein n=2 Tax=Actinomycetales
           RepID=A1RD08_ARTAT
          Length = 322

 Score =  289 bits (741), Expect = 8e-77,   Method: Composition-based stats.
 Identities = 99/329 (30%), Positives = 154/329 (46%), Gaps = 14/329 (4%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +   R ++  G+P GIGP+L V+ A     +     VV  D  ++ + A+  GL +    
Sbjct: 1   MSRARTLLPIGDPNGIGPELAVRAAAEMQAQGSEPPVVVGDRFVVAHYASRFGLSIR--- 57

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
                 A+P    T+ LLPV    P     G++    G   VE +  A     +G  +A+
Sbjct: 58  -ETIGTAEP-IMHTVDLLPVDAMPPAEFKPGRVCAAAGRATVEYVKTAVKSLRHGFGSAI 115

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAK-KVVMMLATEELRVALATTHLPLRDIADA 175
           +  P  +  IN AGI F+G+       S     V +ML  ++LR+   T H  + +    
Sbjct: 116 VAAPHSETAINSAGIVFSGYPSLLSASSGDHLPVFLMLIIDDLRITHVTLHCSVSEALQL 175

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           + P  +   I      L+ K GI  PRI V G+NPHAGEGG  G E+   + PV+ +L  
Sbjct: 176 LNPRSVEAAIRATDATLK-KLGIERPRIGVFGINPHAGEGGLFGDEDARIVAPVVEKLAR 234

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G+ + GP   D L       + D  +AM+HDQG   +K  G      + +G   + +SV
Sbjct: 235 EGLAVVGPTGCDVLL--ADRASYDGFVAMFHDQGHGPIKLLGGRESSALCIGQEIVFSSV 292

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKM 324
            HG A ++AG+G AD+   + AL L   +
Sbjct: 293 GHGAAFDIAGQGIADIAPIVKALKLVASI 321


>UniRef50_O85987 4-hydroxythreonine-4-phosphate dehydrogenase n=8 Tax=Proteobacteria
           RepID=PDXA_SPHAR
          Length = 330

 Score =  277 bits (710), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 92/323 (28%), Positives = 144/323 (44%), Gaps = 18/323 (5%)

Query: 11  PGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQP 67
            G+PAGIGP++ V+             V+   A  +       G    LR          
Sbjct: 16  IGDPAGIGPEVAVRALADGAVHTDSIPVLVGSAAAVERALDFTGTKARLR-VMRGFEKPS 74

Query: 68  QTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
                + ++         +  G+     GH   + L        +G FAA I GP+  G 
Sbjct: 75  DDPAIIDVIDTGALPDGVLPLGEDTEAAGHATAQWLDELDALARDGSFAATIMGPISTGS 134

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
           +  A        +     +  +  +++L    LRVA  T H+ LR + D I+  L+   +
Sbjct: 135 LKLA-----KKLDRVISPTPGESYLVLLTGP-LRVAHLTDHMSLRQVIDVISADLVATAV 188

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
             LH  +++ +GIA+PRI V GLNPHA     MG E+   I P +   RA+G+ + GP+ 
Sbjct: 189 GQLHEAMQS-WGIAQPRIAVAGLNPHA-----MGDEDRLEIAPGIEAARARGIDVEGPIA 242

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
            D++F+       D VLAM+HDQG   +K  GF     I +G P++  SV HGTA ++ G
Sbjct: 243 PDSVFRHCIEGRYDMVLAMFHDQGHIAVKTWGFSGNSVIIMGPPYLHMSVAHGTAYDIVG 302

Query: 306 RGKADVGSFITALNLAIKMIVNT 328
            GKAD    ++A+    ++    
Sbjct: 303 TGKADAAMMLSAMRTCGRLASGR 325


>UniRef50_Q4HSN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Campylobacter
           upsaliensis RM3195 RepID=Q4HSN6_CAMUP
          Length = 339

 Score =  277 bits (709), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 92/346 (26%), Positives = 146/346 (42%), Gaps = 32/346 (9%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPL---------- 54
           +V I+ G+  GI  +LV++  ++             +LL     +L              
Sbjct: 2   KVAISIGDLNGISLELVLKSHKKLSQICTPYYFLHESLLKQGLNLLKKKEIALNLVEFSH 61

Query: 55  ----TLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLN 110
                      +   +  +  T   L +     + AG++  ++G Y   +   AC     
Sbjct: 62  AKISKFEKIKEDKNVKIFSFQTPLSLELNANFTIKAGEIDAQSGTYSFLSFEAACAFTHQ 121

Query: 111 GEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLR 170
               ALIT P+HK   N AGI F GHT+        K  +MML  ++L V L + H+ LR
Sbjct: 122 KHATALITLPIHKKAWNLAGISFRGHTDALRN-FYGKNAIMMLGCKKLFVGLFSEHIALR 180

Query: 171 DIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVL 230
           D++  I    L + +   + +   K      +I V   NPHAG+    GT   +    + 
Sbjct: 181 DVSSQIKLEPLTQFLIDFYQESGFK------KIGVLAFNPHAGD---FGTIGGEEESIIE 231

Query: 231 NELRAQGMKLNGP------LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNI 284
             +R   + +         L AD+ F P  L     ++AMYHD  L  LK   F + VN+
Sbjct: 232 EAIRCANLHIQKEIYLPQILVADSAFTPNSLKKCSRLVAMYHDLALAPLKALYFEKSVNV 291

Query: 285 TLGLPFIRTSVDHGTALELAGRG-KADVGSFITALNLAIKMIVNTQ 329
           +L LP IRTSVDHGTA + A +  K    S+  A+ +A+ +    +
Sbjct: 292 SLNLPIIRTSVDHGTAFDKAYQNAKISTKSYKEAVKIALNLAKKRK 337


>UniRef50_B0SEJ8 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Leptospira
           biflexa serovar Patoc RepID=B0SEJ8_LEPBA
          Length = 314

 Score =  270 bits (691), Expect = 5e-71,   Method: Composition-based stats.
 Identities = 103/321 (32%), Positives = 143/321 (44%), Gaps = 24/321 (7%)

Query: 5   QRVVITPGEPAGIGPDL---VVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           + ++I+ G+P  I  +L      L Q       +             + G      P  P
Sbjct: 2   KTILISEGDPTSINYELLESTFPLLQSLGKEHRIYL-----------IRGSHNQTLPSLP 50

Query: 62  NSPAQPQTAGTLTLL--PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
           N  A     G  ++             G+ +  +G    ++L  A D         LIT 
Sbjct: 51  NLTAPIDAPGFYSITWKGGGKSKSFVLGKPSRASGKMAYDSLLSAIDLQKETGAD-LITL 109

Query: 120 PVHKGVINDAGIP-FTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           P+ K  +  AGI  F GHTE   + +  +   MM++ E+L V   TTH+PL+D+   +T 
Sbjct: 110 PLSKEWVVKAGINGFRGHTETLAD-AYKRPTFMMMSGEKLNVIPLTTHVPLKDVVRELTK 168

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
               E    L   +     +  P+I   GLNPHAGEGG +G EE   +   ++ LR   +
Sbjct: 169 FNWKE----LGRAITQSPYLHHPKIGYLGLNPHAGEGGKIGKEETTLLKQGVSILRKAKL 224

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            L GPL AD+ F P      D  LA YHDQGL   K     +GVNITLGL F R S DHG
Sbjct: 225 SLEGPLSADSAFLPDA-KPYDLYLAGYHDQGLIPFKLLEGKKGVNITLGLDFTRVSPDHG 283

Query: 299 TALELAGRGKADVGSFITALN 319
           TA  +AG+G AD    I+ L 
Sbjct: 284 TAFGIAGKGCADPTGLISCLE 304


>UniRef50_UPI0000D53337 pyridoxal phosphate biosynthesis protein n=1 Tax=Psychroflexus
           torquis ATCC 700755 RepID=UPI0000D53337
          Length = 249

 Score =  262 bits (671), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 94/249 (37%), Positives = 149/249 (59%), Gaps = 8/249 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREW----PVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           + ++ +PG+PAGIGPDL + L    +       +V   D  L  +RA  LG    +  ++
Sbjct: 2   KTIIYSPGDPAGIGPDLFLSLLNENFFRFIKANVVCIGDHELFASRAEKLGYSFEINTFT 61

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
             +    +    +  L +     ++ G+L   N  YV++ L    D C+N +   L+TGP
Sbjct: 62  DINDVNEK----VGCLEIIKCPDISCGRLNAINSEYVIKNLDFGIDTCVNSKDIGLVTGP 117

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           + K  I + G  F+GHTE   E++ +  V+M+LA+E L+VALATTH+PL  ++++IT  L
Sbjct: 118 ISKENIIEGGYSFSGHTERIMEKTNSDDVLMLLASERLKVALATTHIPLNKVSESITTDL 177

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +   + IL+H+L++KF I +P+I + GLNPHAGEGG +G EEI+TIIP + EL+A  + +
Sbjct: 178 IINKVKILNHELKSKFNIEKPKISLLGLNPHAGEGGKLGKEEIETIIPAVKELKASNVDV 237

Query: 241 NGPLPADTL 249
           + PL ADT 
Sbjct: 238 SMPLSADTA 246


>UniRef50_D0J448 Terephthalate dihydrodiol dehydrogenase n=5 Tax=Comamonas
           RepID=D0J448_COMTE
          Length = 306

 Score =  258 bits (659), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 83/315 (26%), Positives = 141/315 (44%), Gaps = 22/315 (6%)

Query: 11  PGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQP 67
            G+P GIGP++ ++  ++    E   + V    + L   A +  +   L+          
Sbjct: 3   IGDPHGIGPEIALKALRQLSANERSLIKVYGPWSALEQAAQICQMESLLQDLIHEEAG-- 60

Query: 68  QTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVIN 127
                      +L  P   G++  + G   V++   A   C NGE  A+I  P H+  I+
Sbjct: 61  -----------SLAQPAQWGEITPQAGLSTVQSATAAIRACENGEVDAVIACPHHETAIH 109

Query: 128 DAGIPFTGHTEFFEERSQ--AKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
            AGI F+G+             +V +ML    LR+   T H  +R   + ++P L+   +
Sbjct: 110 RAGIAFSGYPSLLANVLGMNEDQVFLMLVGAGLRIVHVTLHESVRSALERLSPQLVVNAV 169

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
                   T  G+ +P++ V G+NPHA EG   G E+     P +  LR  G+ ++GP+ 
Sbjct: 170 QAAVQTC-TLLGVPKPQVAVFGINPHASEGQLFGLEDSQITAPAVETLRKCGLAVDGPMG 228

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
           AD +         D  +AM HDQG   +K         +++G   + +SV HG+A+++AG
Sbjct: 229 ADMVL---AQRKHDLYVAMLHDQGHIPIKLLAPNGASALSIGGRVVLSSVGHGSAMDIAG 285

Query: 306 RGKADVGSFITALNL 320
           RG AD  + +  + L
Sbjct: 286 RGVADSTALLRTIAL 300


>UniRef50_P94285 PdxA homolog (Fragment) n=1 Tax=Burkholderia cepacia
           RepID=P94285_BURCE
          Length = 258

 Score =  258 bits (659), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 81/251 (32%), Positives = 122/251 (48%), Gaps = 14/251 (5%)

Query: 67  PQTAGTLTLLPVALRAPVTA--GQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
              +G + +L     AP     GQ +   G  VV  +A A     +G     I GP+   
Sbjct: 1   AFASGRIVVLDPLDLAPHEYVTGQPSAAAGRAVVRWMALADRIAHDGLIGGWIMGPIDST 60

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
            +  AG   +       +  Q +   M   +  LRV   T H+PLRD+   +T   +  +
Sbjct: 61  SLKLAGEVAS------IDELQPEHSFMFRMSGRLRVVPLTEHIPLRDVPATVTFDAVLNL 114

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL 244
           + +++  L+  +GI  PRI V GLNPHA     M  EE   I P + + RAQG+ + GP+
Sbjct: 115 VTLVNERLK-DWGIEAPRIGVAGLNPHA-----MFEEEERIIGPAVEQARAQGIDVRGPV 168

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELA 304
             D++F+       DAV++MYHDQG   LK   F     + LG+P++R +V HGTA+ +A
Sbjct: 169 SPDSVFRHGLDGRYDAVVSMYHDQGQIALKSAAFEGACTLYLGVPYVRATVPHGTAMGIA 228

Query: 305 GRGKADVGSFI 315
           GR  A   S +
Sbjct: 229 GRNLAQHHSMV 239


>UniRef50_UPI0000D53588 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Psychroflexus
           torquis ATCC 700755 RepID=UPI0000D53588
          Length = 262

 Score =  232 bits (593), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 63/260 (24%), Positives = 115/260 (44%), Gaps = 6/260 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPY 59
           +  +V  T G+  GIGP++++              V+      L   A      ++    
Sbjct: 6   RKIKVGFTTGDMNGIGPEILLNSLLNSELLSTCIPVIYGSIINLNYTANHFSYKVSFNRI 65

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
           S    A       +          ++ G L  E G    E++  +      G+   L+T 
Sbjct: 66  SFAEEALEGKINVID--NFKNPPKISFGVLNKEMGFAAYESIKNSVKDLRAGKIDVLVTP 123

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P++K  I+     F GHT++ + +       MM+ + +LRVAL T H+P+  + D+I+P 
Sbjct: 124 PINKEAIHSDEFQFMGHTDYIDGKIDGVST-MMMVSNDLRVALLTEHMPVSRVTDSISPE 182

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
           L+   I +L+  L   F   +P+I +  ++PHAG+GG +   +   I+P +   + +G+ 
Sbjct: 183 LVERKINMLNDTLIRDFQKEQPKIAILSIDPHAGDGGVISENDAQLIVPAVKISKDKGIL 242

Query: 240 LNGPLPADTLFQPKYLDNAD 259
           ++GP PAD+ F        D
Sbjct: 243 IDGPFPADSFFGSMEYKKYD 262


>UniRef50_A7T2T3 Predicted protein (Fragment) n=1 Tax=Nematostella vectensis
           RepID=A7T2T3_NEMVE
          Length = 371

 Score =  232 bits (592), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 57/179 (31%), Positives = 96/179 (53%), Gaps = 1/179 (0%)

Query: 103 RACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVAL 162
            A      G    L+T P++K  I      F GHT++ +   +    +M++  ++ RV L
Sbjct: 1   AATAALKEGLVDVLVTAPINKYNIQSEDFKFPGHTDYLDSELEG-DALMLMIHDKFRVGL 59

Query: 163 ATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEE 222
            T H+P+ +I+ +++  LL + +  +   L   FG+ +P++ + GLNPH+G+ G +G EE
Sbjct: 60  LTDHIPVNEISKSLSEKLLMKKVGTIIKALEQDFGVVKPKVALLGLNPHSGDNGVIGDEE 119

Query: 223 IDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRG 281
              I P + ++   GM + GP  +D+ F     +  DA+LAMYHDQGL   K   FG+ 
Sbjct: 120 EKIIKPTVKKMFDSGMMVFGPYSSDSFFGSSQFEKYDAILAMYHDQGLIPFKTLSFGKA 178


>UniRef50_A1FAW6 Pyridoxal phosphate biosynthetic protein PdxA (Fragment) n=1
           Tax=Vibrio cholerae 2740-80 RepID=A1FAW6_VIBCH
          Length = 197

 Score =  229 bits (584), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 109/195 (55%), Positives = 140/195 (71%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           + ++R+++T GEPAGIGPDLV+ L+ ++WP +LVVCAD  LL  RA  LG+ + L  Y  
Sbjct: 1   MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQR 60

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           ++P Q Q AGTL +  + L  PV AGQL   NGHYV++TL RA  GC+NGEF A++TGPV
Sbjct: 61  DNPVQAQQAGTLLVEHIPLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPV 120

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           HKGVIN AG+ F+GHTEFF E+S+   VVMMLATE LR AL TTHLPL ++  AIT   L
Sbjct: 121 HKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERL 180

Query: 182 HEVIAILHHDLRTKF 196
            +++ ILH DL  K 
Sbjct: 181 EQIVHILHKDLVEKL 195


>UniRef50_C3XJ32 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Helicobacter
           bilis ATCC 43879 RepID=C3XJ32_9HELI
          Length = 391

 Score =  221 bits (563), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 88/402 (21%), Positives = 152/402 (37%), Gaps = 101/402 (25%)

Query: 9   ITPGEPAGIGPDLVVQ-LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQP 67
           ++ G+  GIG +L+++  A+     + + C D  +L   A  L L +           + 
Sbjct: 3   VSVGDINGIGLELILRNHAEIAAYCKPIYCIDFEVLECAAKKLALQIP----------KD 52

Query: 68  QTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH----- 122
                L +  +     + AGQ+  ++G Y  ++  +A +  +  E + L+T P+H     
Sbjct: 53  MYIHPLNMQDIFDDEIIKAGQICAKSGLYSFKSFEKAVELSIEHEAS-LVTLPIHKYAWQ 111

Query: 123 ------------------KGVINDAGIP------FTGHTEF--FEERSQAKKVVMML--- 153
                             K  I   G        FT H            +K++      
Sbjct: 112 LAGIEYAGHTQYLRHRFQKEAIMMLGCKEMFVALFTDHIPLSKVSSLIHKEKLLQFFRDF 171

Query: 154 --ATEELRVALATTHLP------------------LRDIADA------ITPALLHEV--- 184
             A   L   L TT  P                  L++++        I   L+  +   
Sbjct: 172 YKAYSTLFTPLQTTQTPKNDTKHGTQDSKEIQLESLQELSSNTLKQNAINANLVKRLLYD 231

Query: 185 ------------------IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTI 226
                             IA  +H L+ K    E +I V GLNPHAG+ G +G E++  I
Sbjct: 232 EKNIEKTIIEKPQDSIQEIAPHNHSLQPK---KELKIAVLGLNPHAGDNGVLGHEDM-II 287

Query: 227 IPVLNELRAQ-GMKLN-GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNI 284
              +  +  + G ++  G +  D+ F P   +     +AMYHD GL  LK   F R +N+
Sbjct: 288 NECIGIINKEIGAEVFIGSIAPDSAFIPHNRERYSIFIAMYHDSGLAPLKALYFDRSINV 347

Query: 285 TLGLPFIRTSVDHGTALELAGR--GKADVGSFITALNLAIKM 324
           +L LP +RTS DHGT  + A +      + S++ +     ++
Sbjct: 348 SLNLPILRTSPDHGTCFDKAYQSNNNISMESYLESFRFLCQV 389


>UniRef50_A7C3I0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Beggiatoa sp.
           PS RepID=A7C3I0_9GAMM
          Length = 222

 Score =  179 bits (454), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 49/197 (24%), Positives = 81/197 (41%), Gaps = 6/197 (3%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRP 58
           +K   + IT G+PAG+GP++VV+        E    +V  D +++ N          +  
Sbjct: 1   MKKPIIAITLGDPAGVGPEIVVKSFSNPKVYEVCRPLVIGDKSVIANALTFCNKTANIHI 60

Query: 59  YSPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
                  + Q  GT+ L+ +     A +  G +    G    + + +A    + GE  AL
Sbjct: 61  IEKPKQGKYQ-LGTIDLVNLQNIEIAKLQIGTIQAMCGQAAYDYIEKAVQLAMIGEVEAL 119

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  +  A I   GHTE  E  SQ    + M     +RV   + H+ LR   D +
Sbjct: 120 ATTPINKESLRAANIEHIGHTEMLETLSQTNDPLTMFEVRGMRVFFLSRHVSLRQSCDLV 179

Query: 177 TPALLHEVIAILHHDLR 193
           T   + E        L+
Sbjct: 180 TKERVLESSCRCTGALQ 196


>UniRef50_Q47824 4-hydroxythreonine-4-phosphate dehydrogenase (Fragment) n=2
           Tax=Bacteria RepID=PDXA_ENTAG
          Length = 105

 Score =  172 bits (437), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 50/104 (48%), Positives = 66/104 (63%)

Query: 223 IDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGV 282
           I  + P +  ++AQGM + GP P DT+F     D  D V+AMYHDQG   LK  GF  GV
Sbjct: 1   IRILTPAVEAMKAQGMDVYGPCPPDTVFMQCNEDMYDIVVAMYHDQGHIPLKLLGFYDGV 60

Query: 283 NITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIV 326
           NIT GLPF+RTS DHGTA  +A  GKA+  S   ++++A+K+  
Sbjct: 61  NITAGLPFLRTSADHGTAFNIAWTGKANPESMAISIDMAMKITR 104


>UniRef50_D0RPG9 Pyridoxal phosphate biosynthetic protein PdxA n=1 Tax=alpha
           proteobacterium HIMB114 RepID=D0RPG9_9RICK
          Length = 288

 Score =  162 bits (411), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 59/240 (24%), Positives = 100/240 (41%), Gaps = 13/240 (5%)

Query: 66  QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLAR----ACDGCLNGEFAALITGPV 121
             +    + L     +      ++ ++  +Y  + L +      +     +   LI  P+
Sbjct: 32  DAKNFNKIYLFHKKYQKKFEFIRIELKKKNY-FQYLEKITKEGINLFKKKKIKYLINMPL 90

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKV-VMMLATEELRVALATTHLPLRDIADAITPAL 180
           +K         + G TEF+ ++   K    M+L      V   TTH+ ++D+   IT   
Sbjct: 91  NKK--KYLNNRYFGFTEFYSKKIDNKNNENMLLFNNNFSVCPLTTHIQIKDVDKKITHYK 148

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +   +  + +  +         I+V GLNPHAG+  +  +++   I  ++    A    +
Sbjct: 149 IKIALNNIINFYKKIIKKKI-NIIVLGLNPHAGKDFNNNSKDKK-IEKLIFSKFANKNNI 206

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+ ADT F           L MYHDQ L   K +    G+NIT+G  F R S DHGTA
Sbjct: 207 KGPISADTAFTDTSNK---VFLGMYHDQVLIPFKMKNRFNGINITIGKKFYRLSPDHGTA 263


>UniRef50_Q7X217 Putative 4-hydroxthreonine-4-phosphate dehydrogenase (Fragment) n=1
           Tax=Klebsiella pneumoniae RepID=Q7X217_KLEPN
          Length = 183

 Score =  155 bits (393), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 40/178 (22%), Positives = 74/178 (41%), Gaps = 6/178 (3%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPY 59
           K   V IT G+PAGIGP++ V     +   +     +     +++    ++G    +   
Sbjct: 6   KKPVVAITIGDPAGIGPEITVATMMDKSVYDECKPFLIGSVPIISRAMKIMGCDFAIHKI 65

Query: 60  SPNSPAQPQTAGTLTLLPVAL--RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
           +    A+    GTL +L         +  G++    G   ++ + ++ +    G    + 
Sbjct: 66  AHPQEARFSW-GTLDVLETGDYDCDSIEWGKVQKLAGQMSLDYVMKSIELGKAGLIDVVS 124

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           T P+HK  I  AG    GHTE ++  +Q+   + M     LRV   + H+ L+   D 
Sbjct: 125 TAPIHKEAIKLAGCKLPGHTEIYQVETQSDYGLTMFHVHNLRVFFVSRHMALKAACDY 182


>UniRef50_C6SCG8 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Neisseria
           meningitidis alpha153 RepID=C6SCG8_NEIME
          Length = 150

 Score =  116 bits (291), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 53/141 (37%), Positives = 70/141 (49%), Gaps = 6/141 (4%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           +K     +T GEPAGIGPD+ + LA    P    V  D  LL  RA  LG  + LR + P
Sbjct: 1   MKQPVFAVTSGEPAGIGPDICLDLAFARLPCRCAVLGDKNLLRARAEALGKSVVLRDFDP 60

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            S       G L +L +     V AG+L   N  YV++ L  A  G  +G F  ++T P+
Sbjct: 61  ESGGAAY--GELEVLHIPAAEAVEAGRLNPANAAYVLQLLDTALAGISDGIFDGIVTAPL 118

Query: 122 HKGVINDAGIPFTGHTEFFEE 142
           HKG+INDA       T FF+ 
Sbjct: 119 HKGIINDA----RASTGFFQR 135


>UniRef50_C2EXJ2 Putative uncharacterized protein (Fragment) n=4 Tax=Bacteria
          RepID=C2EXJ2_LACRE
          Length = 80

 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 80/80 (100%), Positives = 80/80 (100%)

Query: 2  VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
          VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP
Sbjct: 1  VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 60

Query: 62 NSPAQPQTAGTLTLLPVALR 81
          NSPAQPQTAGTLTLLPVALR
Sbjct: 61 NSPAQPQTAGTLTLLPVALR 80


>UniRef50_UPI000190527A 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Rhizobium etli
           Kim 5 RepID=UPI000190527A
          Length = 104

 Score = 97.9 bits (243), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 26/103 (25%), Positives = 46/103 (44%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            + + IT G+P GIGP+++ ++     P + VV  D  ++     +L LPL ++P +   
Sbjct: 2   KKPIGITMGDPCGIGPEIIARVFADGLPEQAVVIGDTKVMERAVRVLNLPLQVQPIASVD 61

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACD 106
              P +     L    L   +  GQ+    G    + + RA D
Sbjct: 62  NVLPDSGLIAVLNVSDLPDDLPIGQVDARAGRASYDYVVRAID 104


>UniRef50_UPI00016999D5 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Endoriftia
           persephone 'Hot96_1+Hot96_2' RepID=UPI00016999D5
          Length = 103

 Score = 87.1 bits (215), Expect = 7e-16,   Method: Composition-based stats.
 Identities = 36/62 (58%), Positives = 43/62 (69%), Gaps = 1/62 (1%)

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIA 186
           N+AG PFTGHTE+  +  Q+ + VMMLATE LRVALATTHLPL  ++  IT   L  VI 
Sbjct: 1   NEAGHPFTGHTEYLAQLCQS-EAVMMLATEGLRVALATTHLPLSQVSAQITRERLERVIR 59

Query: 187 IL 188
            L
Sbjct: 60  TL 61


>UniRef50_B6YQG1 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Azobacteroides pseudotrichonymphae genomovar. CFP2
           RepID=B6YQG1_AZOPC
          Length = 326

 Score = 79.4 bits (195), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 56/321 (17%), Positives = 103/321 (32%), Gaps = 64/321 (19%)

Query: 22  VVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPV 78
           ++Q        EL   ++   +T+L+    +  LP+          A      +L ++ +
Sbjct: 20  IIQTFSEVRIFELCVPIIYDYSTVLSYYRKIRRLPIRTTNIHN---ANKSIKNSLNIIDI 76

Query: 79  ALRA-PVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHT 137
           + +A P+T G+  +++   + E+  R       GE    +T       I           
Sbjct: 77  SNKALPMTVGKTNIKSNTAIGESFYRGLSDLKVGEIDVFVTSSTSTDSIQQIE------- 129

Query: 138 EFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFG 197
               E    KK + +L  +  R+A  +   P       I   +L E I  LH  L   F 
Sbjct: 130 ---SELLDEKKSLPILTNDYFRIAEISNSTP-------INIDILTEKIKNLHSTLLHDFM 179

Query: 198 IAEPRILVCGLN-PHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLD 256
           +  PRI +   N P             + I         +G+        ++ F      
Sbjct: 180 VTFPRIAIVSENSP------------AEIITDATQIAFREGIFCFSTFNPESFFNSDIYK 227

Query: 257 NADAVL---AMYHD---QGLPVLKYQGFGRGVNITL--GLPFIRTSVDHGTALELAGRGK 308
             DA L    M  +   Q +  +         N  L   +P++                 
Sbjct: 228 KFDAALIINCMSTNFIFQSIQPV-----SEQTNAILISNMPYVVA--------------I 268

Query: 309 ADVGSFITALNLAIKMIVNTQ 329
           A+  S   ++ LAI +  N +
Sbjct: 269 ANSTSLTPSIYLAIDVYRNRK 289


>UniRef50_UPI000190303C 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Rhizobium
          etli RepID=UPI000190303C
          Length = 97

 Score = 72.4 bits (177), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 22/92 (23%), Positives = 41/92 (44%), Gaps = 3/92 (3%)

Query: 4  TQRVVITPGEPAGIGPDLVVQLAQREWPV---ELVVCADATLLTNRAAMLGLPLTLRPYS 60
          ++ + ++ G+PAGIGPD+ +    R   +      +  D  +L  RA  L L +++R   
Sbjct: 6  SRPLALSQGDPAGIGPDITLMAWLRRRELGLPPFFLIGDPDVLALRARQLNLAVSIREID 65

Query: 61 PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVE 92
              +    A  L ++ V +   V AG+    
Sbjct: 66 SADESTGSFADALPVMSVPVGIEVVAGEPHAA 97


>UniRef50_C2BLM4 Putative uncharacterized protein (Fragment) n=1 Tax=Corynebacterium
           pseudogenitalium ATCC 33035 RepID=C2BLM4_9CORY
          Length = 79

 Score = 68.6 bits (167), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 21/71 (29%), Positives = 35/71 (49%), Gaps = 2/71 (2%)

Query: 69  TAGTLTLLPV--ALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
            AG + ++    AL A +  GQ+    G    + +  A D    G   A++T P++K  +
Sbjct: 9   AAGHIDVIACSPALPADLPLGQVHAAAGRGAYDYVCAAIDDAQAGRIRAIVTAPLNKKSM 68

Query: 127 NDAGIPFTGHT 137
           + AGI + GHT
Sbjct: 69  HAAGIDYPGHT 79


>UniRef50_B5YG77 Phosphate acyltransferase n=2 Tax=Bacteria RepID=PLSX_THEYD
          Length = 345

 Score = 48.6 bits (115), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 34/258 (13%), Positives = 81/258 (31%), Gaps = 30/258 (11%)

Query: 21  LVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVAL 80
           + V     ++  E+ +     ++ +    + L    +      P + +T G ++++P   
Sbjct: 4   IAVDAMGGDFAPEVNILGAYEVVQDIEVEIILVGDEKKIKSFLPEKKETKGIISVIPADD 63

Query: 81  RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFF 140
              +   +           ++ +A +    G+  A+I+      ++  + +         
Sbjct: 64  V--IQMDENISSALRRKNTSMRKAVELVKAGKADAVISAGHSGAMMALSFL-------LL 114

Query: 141 EERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TPALLHEVIAILHHDLRTKFGI 198
            +    ++  +      L+      H  L D    +   P  L +   +     +  F  
Sbjct: 115 GKLPNVERPAIATVMPCLK-----GHFILLDAGANVDCKPEHLVQFAFMGEAYHKALFNS 169

Query: 199 AEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL-PADTLFQPKYLDN 257
             P+I +  +    GE G  G E           L++  +   G +   D  F    +  
Sbjct: 170 QSPKIALLSI----GEEGSKGNE---LTKEAFKLLKSSRLNFVGNIEGKDIFFGQADVVV 222

Query: 258 ADAVLAMYHDQGLPVLKY 275
            D  +      G  VLK 
Sbjct: 223 CDGFV------GNIVLKV 234


>UniRef50_UPI00016A5E6C 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Burkholderia
          ubonensis Bu RepID=UPI00016A5E6C
          Length = 52

 Score = 44.3 bits (104), Expect = 0.005,   Method: Composition-based stats.
 Identities = 15/44 (34%), Positives = 20/44 (45%), Gaps = 4/44 (9%)

Query: 6  RVVITPGEPAGIGPDLVVQLAQREW----PVELVVCADATLLTN 45
           + IT GEPAG+GP+L  Q  +            V  DA L+  
Sbjct: 7  HIAITTGEPAGVGPELTAQALRDAGERWPDARFTVLGDAALVAE 50


>UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms
           RepID=LEU3_ARCFU
          Length = 326

 Score = 43.5 bits (102), Expect = 0.009,   Method: Composition-based stats.
 Identities = 9/33 (27%), Positives = 17/33 (51%), Gaps = 3/33 (9%)

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
             HG A ++AG+G A+  +    +  A  M+ +
Sbjct: 252 PVHGAAFDIAGKGIANPTAM---ILTACMMLRH 281


>UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2
           Tax=environmental samples RepID=B3TCK6_9ARCH
          Length = 339

 Score = 43.2 bits (101), Expect = 0.014,   Method: Composition-based stats.
 Identities = 10/34 (29%), Positives = 19/34 (55%)

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
             HG A ++AG+  A+  SFI ++ + +  + N 
Sbjct: 259 PVHGAAFDIAGKQIANPTSFILSIKMMLDWLGNK 292


>UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37
           RepID=A1SWV5_PSYIN
          Length = 368

 Score = 42.8 bits (100), Expect = 0.017,   Method: Composition-based stats.
 Identities = 11/31 (35%), Positives = 20/31 (64%)

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMI 325
             HG+A ++AG+G A+  S I ++ L ++M 
Sbjct: 283 PSHGSAPDIAGKGIANPYSMIGSVALMLEMS 313


>UniRef50_B2JJC7 ATP-dependent helicase HrpA n=89 Tax=cellular organisms
           RepID=B2JJC7_BURP8
          Length = 1462

 Score = 41.6 bits (97), Expect = 0.034,   Method: Composition-based stats.
 Identities = 28/163 (17%), Positives = 57/163 (34%), Gaps = 19/163 (11%)

Query: 40  ATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVE 99
           A ++     +  + +  RP + +SPA     G         R          E    +++
Sbjct: 335 APVIEVSGRLYPVEVRYRPVADDSPAVKAAEGNSGREHRPDRPKTQR-----ETDRDLMD 389

Query: 100 TL-ARACDGCLNGEFAALITGPVHKGVINDAGI---PFTGHTEFF---EERSQAKKVVMM 152
            +   A + C  G    L+  P  + + + A         HTE        S A++  + 
Sbjct: 390 AIVEAADELCREGPGDVLVFLPGEREIRDAAEALRKHHPPHTEILPLFARLSAAEQERVF 449

Query: 153 LATEELRVALATTHLPLRDIAD-AITPALLHEVIAILHHDLRT 194
             +   R+ LAT      ++A+ ++T   +  VI      ++ 
Sbjct: 450 RPSNARRIVLAT------NVAETSLTVPGIRYVIDTGLARVKR 486


>UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria
           RepID=LEU3_RHIEC
          Length = 370

 Score = 40.9 bits (95), Expect = 0.066,   Method: Composition-based stats.
 Identities = 9/33 (27%), Positives = 19/33 (57%)

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
             HG+A ++AG+G A+  + I +  + ++   N
Sbjct: 287 PVHGSAPDIAGKGIANPIAMIASFAMCLRYSFN 319


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_D2QDF7 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   447   e-124
UniRef50_Q11UL9 Pyridoxal phosphate biosynthesis protein n=3 Tax...   437   e-121
UniRef50_C6VZ75 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   431   e-119
UniRef50_Q8CUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   427   e-118
UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   427   e-118
UniRef50_A6TJU5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   426   e-118
UniRef50_B0KBL6 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   426   e-118
UniRef50_A1U6F9 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   424   e-117
UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic prot...   421   e-116
UniRef50_D1UTB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   420   e-116
UniRef50_C5ELY2 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   419   e-116
UniRef50_C0QBU5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   417   e-115
UniRef50_B8FEI1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   417   e-115
UniRef50_B2U6L2 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   416   e-115
UniRef50_Q89ZK3 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   416   e-115
UniRef50_Q3IFD2 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   415   e-115
UniRef50_B1B883 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   412   e-113
UniRef50_A0JTQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=9...   411   e-113
UniRef50_A0LIN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   410   e-113
UniRef50_Q2S3U3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   410   e-113
UniRef50_B2V9E6 4-hydroxythreonine-4-phosphate dehydrogenase n=5...   409   e-112
UniRef50_P58718 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   406   e-112
UniRef50_A3ERM0 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   403   e-111
UniRef50_C8QYR8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   402   e-111
UniRef50_B7UKV9 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   401   e-110
UniRef50_C7R7U0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   401   e-110
UniRef50_Q1NMK1 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   401   e-110
UniRef50_C9LG48 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   399   e-110
UniRef50_A6L8G2 4-hydroxythreonine-4-phosphate dehydrogenase n=7...   399   e-109
UniRef50_A6DS02 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   398   e-109
UniRef50_C6E7W5 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   398   e-109
UniRef50_C7PP38 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   397   e-109
UniRef50_C7M3J3 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   396   e-109
UniRef50_B2IDU5 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   396   e-109
UniRef50_C4X874 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   396   e-109
UniRef50_Q87ST5 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   394   e-108
UniRef50_Q89NF3 4-hydroxythreonine-4-phosphate dehydrogenase 1 n...   392   e-107
UniRef50_Q1GI38 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   390   e-107
UniRef50_A6H263 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   390   e-107
UniRef50_B5YL57 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   389   e-107
UniRef50_C1SJH6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   389   e-106
UniRef50_A7HYG3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   388   e-106
UniRef50_Q7UMZ2 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   387   e-106
UniRef50_C6X2C9 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   387   e-106
UniRef50_C6P2R8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   386   e-106
UniRef50_B4S6L0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   386   e-106
UniRef50_B1L710 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   386   e-106
UniRef50_A5CWR9 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   386   e-106
UniRef50_C6XKP9 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   385   e-105
UniRef50_C6XHX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   385   e-105
UniRef50_Q02C14 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   385   e-105
UniRef50_Q6AB12 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   384   e-105
UniRef50_Q0FGB3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   384   e-105
UniRef50_A6GTC8 Pyridoxal phosphate biosynthetic protein PdxA n=...   384   e-105
UniRef50_UPI0000E87C06 4-hydroxythreonine-4-phosphate dehydrogen...   383   e-105
UniRef50_Q215S3 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   383   e-105
UniRef50_D0LQB4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   383   e-105
UniRef50_A0LA33 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   380   e-104
UniRef50_C0CYU8 Putative uncharacterized protein n=1 Tax=Clostri...   380   e-104
UniRef50_B1IGV8 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   380   e-104
UniRef50_Q2N8X0 4-hydroxythreonine-4-phosphate dehydrogenase n=5...   377   e-103
UniRef50_C6C747 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   377   e-103
UniRef50_A6C4H6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   376   e-103
UniRef50_P58711 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   375   e-102
UniRef50_Q8D3I2 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   373   e-102
UniRef50_Q5NMX3 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   372   e-101
UniRef50_D0J9Z1 4-hydroxythreonin-phosphate dehydrogenase n=1 Ta...   371   e-101
UniRef50_A8S524 Putative uncharacterized protein n=1 Tax=Clostri...   371   e-101
UniRef50_D2R6V9 4-hydroxythreonine-4-phosphate dehydrogenase n=7...   370   e-101
UniRef50_A0NP49 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   369   e-101
UniRef50_Q92X16 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   369   e-101
UniRef50_Q0EWH4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   368   e-100
UniRef50_Q4JN67 Predicted 4-hydroxythreonine-4-phosphate dehydro...   367   e-100
UniRef50_Q30Z16 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   365   e-99 
UniRef50_A7IJ81 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   365   1e-99
UniRef50_Q475Q2 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   365   1e-99
UniRef50_C3JBU1 4-hydroxythreonine-4-phosphate dehydrogenase n=5...   365   2e-99
UniRef50_UPI00019F1502 4-hydroxythreonine-4-phosphate dehydrogen...   363   4e-99
UniRef50_Q2CJB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   360   4e-98
UniRef50_Q8DHB4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   360   4e-98
UniRef50_D2TK32 Putative uncharacterized protein n=1 Tax=Citroba...   360   4e-98
UniRef50_Q1DF36 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   359   8e-98
UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n...   359   1e-97
UniRef50_Q87AJ1 4-hydroxythreonine-4-phosphate dehydrogenase n=7...   357   5e-97
UniRef50_B8FR92 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   356   6e-97
UniRef50_A8ME07 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   356   7e-97
UniRef50_A5WDW5 4-hydroxythreonine-4-phosphate dehydrogenase n=6...   352   9e-96
UniRef50_B8IXF1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   352   1e-95
UniRef50_Q92TP3 4-hydroxythreonine-4-phosphate dehydrogenase 3 n...   350   3e-95
UniRef50_B1GZF5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   349   1e-94
UniRef50_Q2KXH9 4-hydroxythreonine-4-phosphate dehydrogenase n=9...   348   2e-94
UniRef50_D0RQA4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   347   3e-94
UniRef50_Q9CKG8 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   346   6e-94
UniRef50_C5CPN5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   345   9e-94
UniRef50_B9XEU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   344   3e-93
UniRef50_Q390F1 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   343   4e-93
UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   343   4e-93
UniRef50_B2KET4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   342   1e-92
UniRef50_B4U950 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   342   1e-92
UniRef50_UPI0000D5482C 4-hydroxythreonine-4-phosphate dehydrogen...   340   5e-92
UniRef50_C5SNX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   339   6e-92
UniRef50_A1TTF8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   339   9e-92
UniRef50_Q30S58 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   339   9e-92
UniRef50_B4D0B0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   337   5e-91
UniRef50_A6FY83 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   335   1e-90
UniRef50_A1VC56 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   334   2e-90
UniRef50_B1ZQS3 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   334   2e-90
UniRef50_A7HIW4 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   333   5e-90
UniRef50_B2UL26 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   333   5e-90
UniRef50_Q31DF6 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   332   1e-89
UniRef50_B5JFI3 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   331   2e-89
UniRef50_Q17ZN0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   328   2e-88
UniRef50_Q7MAP7 PDXA HOMOLOG n=1 Tax=Wolinella succinogenes RepI...   327   3e-88
UniRef50_C9PYW4 Pyridoxal phosphate biosynthetic protein PdxA n=...   327   5e-88
UniRef50_C0A8L4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   325   1e-87
UniRef50_Q0C095 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   323   4e-87
UniRef50_B3DY74 Pyridoxal phosphate biosynthesis protein n=1 Tax...   322   8e-87
UniRef50_C3XMM1 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   320   6e-86
UniRef50_C1A9L0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   320   6e-86
UniRef50_B6BUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   317   3e-85
UniRef50_Q04UJ6 4-hydroxythreonine-4-phosphate dehydrogenase n=4...   316   9e-85
UniRef50_A5GHP5 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   315   1e-84
UniRef50_A9GKN1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   313   6e-84
UniRef50_UPI00019786BC 4-hydroxythreonine-4-phosphate dehydrogen...   311   2e-83
UniRef50_A9LFJ9 Pyridoxal phosphate biosynthetic protein (Fragme...   310   5e-83
UniRef50_Q4FMQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=3...   308   2e-82
UniRef50_Q3V7R5 Pyridoxal phosphate biosynthetic protein n=1 Tax...   306   7e-82
UniRef50_D0E8J8 Pyridoxal phosphate biosynthesis protein n=1 Tax...   304   3e-81
UniRef50_C5T2H3 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   302   2e-80
UniRef50_Q0RWE6 Terephthalate dihydrodiol dehydrogenase n=2 Tax=...   299   1e-79
UniRef50_A1RD08 Pyridoxal phosphate biosynthetic protein n=2 Tax...   295   1e-78
UniRef50_Q5HTM4 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   295   2e-78
UniRef50_O85987 4-hydroxythreonine-4-phosphate dehydrogenase n=8...   291   2e-77
UniRef50_Q4HSN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   285   1e-75
UniRef50_B0SEJ8 4-hydroxythreonine-4-phosphate dehydrogenase n=2...   277   4e-73
UniRef50_D0J448 Terephthalate dihydrodiol dehydrogenase n=5 Tax=...   269   1e-70
UniRef50_C3XJ32 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   260   5e-68
UniRef50_UPI0000D53337 pyridoxal phosphate biosynthesis protein ...   260   8e-68
UniRef50_P94285 PdxA homolog (Fragment) n=1 Tax=Burkholderia cep...   259   9e-68
UniRef50_UPI0000D53588 4-hydroxythreonine-4-phosphate dehydrogen...   249   9e-65
UniRef50_A7T2T3 Predicted protein (Fragment) n=1 Tax=Nematostell...   233   6e-60
UniRef50_A1FAW6 Pyridoxal phosphate biosynthetic protein PdxA (F...   218   2e-55
UniRef50_A7C3I0 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   191   4e-47
UniRef50_D0RPG9 Pyridoxal phosphate biosynthetic protein PdxA n=...   174   5e-42
UniRef50_Q7X217 Putative 4-hydroxthreonine-4-phosphate dehydroge...   172   1e-41
UniRef50_Q47824 4-hydroxythreonine-4-phosphate dehydrogenase (Fr...   169   9e-41
UniRef50_B6YQG1 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   155   2e-36
UniRef50_C6SCG8 4-hydroxythreonine-4-phosphate dehydrogenase n=1...   112   2e-23
UniRef50_B5YG77 Phosphate acyltransferase n=2 Tax=Bacteria RepID...   110   7e-23
UniRef50_UPI000190527A 4-hydroxythreonine-4-phosphate dehydrogen...   104   5e-21
UniRef50_UPI00016999D5 4-hydroxythreonine-4-phosphate dehydrogen...    87   1e-15
UniRef50_C2EXJ2 Putative uncharacterized protein (Fragment) n=4 ...    82   3e-14
UniRef50_UPI000190303C 4-hydroxythreonine-4-phosphate dehydrogen...    77   6e-13
UniRef50_C2BLM4 Putative uncharacterized protein (Fragment) n=1 ...    71   4e-11

Sequences not found previously or not previously below threshold:

UniRef50_A7I3D5 Phosphate acyltransferase n=2 Tax=Campylobactera...    57   1e-06
UniRef50_B1I2E9 Phosphate acyltransferase n=1 Tax=Candidatus Des...    54   1e-05
UniRef50_B1H0Q6 Phosphate acyltransferase n=1 Tax=uncultured Ter...    52   4e-05
UniRef50_B4S1N6 Fatty acid/phospholipid synthesis protein n=1 Ta...    51   7e-05
UniRef50_UPI00016A5E6C 4-hydroxythreonine-4-phosphate dehydrogen...    50   1e-04
UniRef50_O67186 Phosphate acyltransferase n=8 Tax=Aquificales Re...    50   2e-04
UniRef50_C0GMU0 Fatty acid/phospholipid synthesis protein PlsX n...    49   2e-04
UniRef50_B1ZWC5 Fatty acid/phospholipid synthesis protein PlsX n...    47   6e-04
UniRef50_Q3ZZV6 Phosphate acyltransferase n=5 Tax=Dehalococcoide...    47   6e-04
UniRef50_C8WW98 Fatty acid/phospholipid synthesis protein PlsX n...    46   0.002
UniRef50_Q2RJX9 Phosphate acyltransferase n=3 Tax=Clostridia Rep...    46   0.002
UniRef50_Q1MS07 Phosphate acyltransferase n=6 Tax=Desulfovibrion...    46   0.002
UniRef50_C7IPB4 Fatty acid/phospholipid synthesis protein PlsX (...    45   0.003
UniRef50_D1B5P2 Fatty acid/phospholipid synthesis protein PlsX n...    45   0.003
UniRef50_Q3AC51 Phosphate acyltransferase n=1 Tax=Carboxydotherm...    44   0.006
UniRef50_Q1IJ05 Phosphate acyltransferase n=10 Tax=Bacteria RepI...    44   0.006
UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula...    44   0.007
UniRef50_B0K1W5 Phosphate acyltransferase n=10 Tax=Thermoanaerob...    44   0.008
UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas...    43   0.012
UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom...    43   0.013
UniRef50_A0LI09 Phosphate acyltransferase n=1 Tax=Syntrophobacte...    43   0.017
UniRef50_B2KC86 Phosphate acyltransferase n=5 Tax=Bacteria RepID...    42   0.024
UniRef50_Q2JJA1 Phosphate acyltransferase n=13 Tax=Bacteria RepI...    42   0.029
UniRef50_B3T0Q5 Putative fatty acid synthesis protein n=2 Tax=pr...    42   0.031
UniRef50_C9RQT8 Phosphate acetyltransferase n=3 Tax=Bacteria Rep...    42   0.035
UniRef50_D1C2Y6 Fatty acid/phospholipid synthesis protein PlsX n...    42   0.038
UniRef50_A8SMT8 Putative uncharacterized protein n=1 Tax=Parvimo...    41   0.050
UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr...    41   0.056
UniRef50_Q4KGI2 Putative uncharacterized protein n=1 Tax=Pseudom...    41   0.060
UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul...    41   0.065
UniRef50_C9RCW3 Fatty acid/phospholipid synthesis protein PlsX n...    41   0.066
UniRef50_C0ZFP6 Phosphate acyltransferase n=2 Tax=Firmicutes Rep...    41   0.069

>UniRef50_D2QDF7 4-hydroxythreonine-4-phosphate dehydrogenase n=8 Tax=Bacteroidetes
           RepID=D2QDF7_9SPHI
          Length = 546

 Score =  447 bits (1150), Expect = e-124,   Method: Composition-based stats.
 Identities = 113/331 (34%), Positives = 169/331 (51%), Gaps = 5/331 (1%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREW---PVELVVCADATLLTNRAAMLGL-PLTLRP 58
           +   + I+ G+  GIGP+++++  Q          V+     +L     +L L    L  
Sbjct: 206 ERLVIGISLGDYNGIGPEVILKALQYNRLQKICTPVIYGSMRILNRYRNLLNLKDWNLNG 265

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                    +    +T  P      +  GQ+  + G   +  L RA D   +G+  AL+T
Sbjct: 266 AQTIGQISHKLTNVITCWP-DQNQDIQPGQVTADAGQAALACLQRAVDDLKDGKIDALVT 324

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P++K  I      F GHTE+  +    +  +M L ++ LRV + T H+PL  +   IT 
Sbjct: 325 APINKNNIQSDEFKFPGHTEYLAQEFGVQDNLMFLVSQTLRVGVVTGHVPLGRVRQNITR 384

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + + + ++ H L+  FGI +P+I V GLNPHAGE G +GTEE D I P++ + R +G 
Sbjct: 385 ERIAQKLTLMMHSLKQDFGIEKPKIAVLGLNPHAGEEGLLGTEENDIIKPLIADWRNKGQ 444

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            + GP PAD  F  +     DAVLAMYHDQGL   K   F  GVN T G+P +RTS DHG
Sbjct: 445 LVFGPYPADGFFGTRAYTKFDAVLAMYHDQGLIPFKAIAFEEGVNFTAGMPAVRTSPDHG 504

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           TA ++AG+  AD  S + A+  AI +  N +
Sbjct: 505 TAYDIAGKDLADETSMLQAIYTAIDVARNRK 535


>UniRef50_Q11UL9 Pyridoxal phosphate biosynthesis protein n=3 Tax=Sphingobacteriales
           RepID=Q11UL9_CYTH3
          Length = 341

 Score =  437 bits (1126), Expect = e-121,   Method: Composition-based stats.
 Identities = 126/330 (38%), Positives = 171/330 (51%), Gaps = 7/330 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGL--PLTLR 57
               + IT G+  G+GP+L+++             V+ A+  LL     +LGL   L   
Sbjct: 8   DRPVIGITLGDFNGVGPELILKTFSDSRILKVCIPVIYANYKLLARYKKILGLYEELNFH 67

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                   QP+    L          VT GQ   E+G     +L +A    L G   A++
Sbjct: 68  SIRSIQEVQPKKINLLVCW--EDDFEVTPGQPTNESGKAAFLSLEKAVSDALAGSIQAIV 125

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           T P+ K  I   G  F GHTE+  ER   K  +M++ +  ++VALAT H+ +  I   +T
Sbjct: 126 TAPIDKKNIQQEGFTFAGHTEYLAERCGVKDNLMVMVSPTMKVALATAHVSVAQITANLT 185

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              L   I +L++ L+  FGI +P+I V GLNPHAGE G MGTEE   I PV+ EL+ +G
Sbjct: 186 RERLLTKINLLYNSLKKDFGILKPKIAVLGLNPHAGENGMMGTEEQTLISPVIKELKDKG 245

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           + + GP PAD  F   +    D VLAMYHDQGL   K   F  GVN T GLPFIRTS DH
Sbjct: 246 ILIFGPFPADGFFGQHHYTKFDGVLAMYHDQGLAPFKALCFDEGVNFTGGLPFIRTSPDH 305

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVN 327
           GTA +LAG+      SF +A+ LA  ++ N
Sbjct: 306 GTAYDLAGKNLVAEESFRSAIYLACDLVKN 335


>UniRef50_C6VZ75 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Dyadobacter
           fermentans DSM 18053 RepID=C6VZ75_DYAFD
          Length = 368

 Score =  431 bits (1108), Expect = e-119,   Method: Composition-based stats.
 Identities = 113/330 (34%), Positives = 167/330 (50%), Gaps = 5/330 (1%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGL-PLTLRP 58
               + IT G+  GIGP+++++  +          ++     +L     +L +   TL  
Sbjct: 7   DKPVIGITIGDYNGIGPEVILKALEGNQLAKLCTPIIYGSLRVLNQYRNLLEMKDWTLHG 66

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                 A  +    +T      +  +  G++  E G      L RA +    G   AL+T
Sbjct: 67  IQKAEQANHKLTNVITCWH-DHQTEIQPGKITAEAGQGSFAALKRAVEDLKEGRIQALVT 125

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           GP++K  I +    F GHTEF  +  +    +M +   +LRV + T H+PL+++ + ITP
Sbjct: 126 GPINKDNIQNDDFKFPGHTEFLAQSFEKDDALMFMVAGDLRVGVLTGHMPLQNVREHITP 185

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             L   I  +   L+  FGI +P++ V GLNPHAGE G +G+EEI+ I PV+ + + +G 
Sbjct: 186 EKLSAKIEQILQSLKGDFGIKKPKLAVLGLNPHAGENGLLGSEEIEIIQPVIKQFKEKGH 245

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            + GP PAD  F        DAVLAMYHDQGL   K   F  GVN T GLP +RTS DHG
Sbjct: 246 LVVGPFPADGFFAAGTYRQYDAVLAMYHDQGLIPFKTLAFNEGVNFTAGLPAVRTSPDHG 305

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNT 328
           TA  +AG+  A+ GS + AL LA  +    
Sbjct: 306 TAYNIAGKNVAEPGSLLQALYLACDVSRFR 335


>UniRef50_Q8CUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=45 Tax=Bacteria
           RepID=PDXA_OCEIH
          Length = 332

 Score =  427 bits (1100), Expect = e-118,   Method: Composition-based stats.
 Identities = 118/330 (35%), Positives = 182/330 (55%), Gaps = 6/330 (1%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLR 57
           M K   + IT G+ AG+GP+++++  +     E    +V  D  +L   A +L + ++  
Sbjct: 1   MSKKPIIGITMGDAAGVGPEIIIKSLRNRELYEQAHPIVIGDTKMLERAAKILDVDVSFD 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVA-LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
             + +        G +T + +  L   +  G+++  +G+   E L  A +    G+  A+
Sbjct: 61  KKTKDEELMDTEFGKITCIDLDILPEDLAYGEVSPVSGNAAFEYLRMAIELANEGKIQAI 120

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  +   G  + GHTE   E +  ++  MML++ +L+V   TTH+ L      I
Sbjct: 121 CTAPLNKEALQKGGHMYPGHTEILAELTNTEEFSMMLSSPKLKVIHVTTHVGLIQAIQMI 180

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRA 235
            P  +H+VI + H  L +  GI  P+I VCG+NPHAGE G  G  EE + IIP + +   
Sbjct: 181 KPERVHKVIQLAHETL-SNSGIKNPKIGVCGINPHAGENGLFGNGEEEEKIIPAIQQAVK 239

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G+ + GPLPADTLF      + D V+AMYHDQG   +K  G   GVNIT+GLP IRTSV
Sbjct: 240 EGINVEGPLPADTLFFRAQRGDFDIVVAMYHDQGHGPIKVLGLEAGVNITVGLPIIRTSV 299

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMI 325
           DHGTA ++AG+G  D  S + AL+ AI++ 
Sbjct: 300 DHGTAFDIAGKGIVDERSMLEALHQAIELA 329


>UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Lactobacillus
           paracasei subsp. paracasei 8700:2 RepID=C5F751_LACPA
          Length = 326

 Score =  427 bits (1099), Expect = e-118,   Method: Composition-based stats.
 Identities = 116/323 (35%), Positives = 179/323 (55%), Gaps = 4/323 (1%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPV--ELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           + IT G+P+GIGP++ ++   +      E ++     ++T  A +L +   L        
Sbjct: 5   IGITIGDPSGIGPEISLKALMKNEQYLNESIIFGSKEIMTYYADLLKIKTPLNFIKDVDQ 64

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
            +        ++ + L   +  G+++  +G    + L  A D  +  +   ++T P++K 
Sbjct: 65  FEAGKINIYNVMDIPL-DKIPIGEVSPISGDAAFQFLKVAIDLAMKKKIGPVVTAPLNKD 123

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
            ++  G  F GHTE F E +  KK  MML +++L V   +TH+PLR   D +T A + E 
Sbjct: 124 ALHKGGHNFDGHTEIFAEFTGTKKYTMMLWSKKLAVVHVSTHVPLRKACDLVTKARVEEC 183

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL 244
           I + +  ++ + GI++PRI V GLNPHAGE G  G EEI  I P + E ++QG+ + G L
Sbjct: 184 IDLANSAIK-RLGISKPRIAVAGLNPHAGEDGLFGDEEIKEINPAVKEKQSQGIDVQGAL 242

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELA 304
           P DT+F        D V+AMYHDQG   +K   F  GVN+TLGLP IRTSVDHGTA ++A
Sbjct: 243 PPDTVFLKASQGKFDIVVAMYHDQGHIPMKLLAFDEGVNVTLGLPIIRTSVDHGTAFDIA 302

Query: 305 GRGKADVGSFITALNLAIKMIVN 327
           G+G A+  S + ++ LAIK   N
Sbjct: 303 GKGIANESSMLASIALAIKFGHN 325


>UniRef50_A6TJU5 4-hydroxythreonine-4-phosphate dehydrogenase n=14 Tax=Bacteria
           RepID=A6TJU5_ALKMQ
          Length = 346

 Score =  426 bits (1097), Expect = e-118,   Method: Composition-based stats.
 Identities = 121/344 (35%), Positives = 172/344 (50%), Gaps = 18/344 (5%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLR 57
           M K   + IT G+P GIGP++  +    +        +V   A +L    A+    L + 
Sbjct: 1   MNKLPILGITMGDPCGIGPEITAKALVHKNVYEVCRPIVVGSAKVLEAAIAICNKDLKVN 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRA--PVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
             S    A+    GT+ +          +  GQ++   G    E + +  D  + GE   
Sbjct: 61  VVSNVKEAKFAF-GTIDVFDQDHVDVWSLVRGQVSKIGGQGAYEAIEKVIDLAMKGEIDG 119

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
            ITGP++K  +N AG  + GHTE + + +  K   MMLA   LRV   +TH+ LR+  D 
Sbjct: 120 TITGPLNKEALNIAGYHYGGHTEIYAKLTGTKDYSMMLADGNLRVVHVSTHVSLREACDR 179

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
            T   +  VI +     ++  GI  PRI V GLNPH+GE G  G EEID IIP + + ++
Sbjct: 180 CTKERVGSVIKLAEEACKS-LGINRPRIAVAGLNPHSGENGLFGREEIDEIIPAIEKAKS 238

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFG-----------RGVNI 284
           +G+ + GP P DTLF        D V+AMYHDQG   +K  GF             GVNI
Sbjct: 239 EGLDVEGPEPPDTLFSKALGGQYDIVVAMYHDQGHIPVKVVGFQYNHELKRWNTVSGVNI 298

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           TLGLP IR+SVDHGTA   AG+G A+  S + A++   ++ V  
Sbjct: 299 TLGLPIIRSSVDHGTAFGQAGKGTANEESLVNAIDYGARLAVTR 342


>UniRef50_B0KBL6 4-hydroxythreonine-4-phosphate dehydrogenase n=3
           Tax=Thermoanaerobacter RepID=B0KBL6_THEP3
          Length = 331

 Score =  426 bits (1095), Expect = e-118,   Method: Composition-based stats.
 Identities = 122/326 (37%), Positives = 174/326 (53%), Gaps = 5/326 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPYS 60
              V IT G+PAG+GP++ ++ A           ++     +L   A +L + + LR   
Sbjct: 2   RPLVAITMGDPAGVGPEISLKAAVSAEVSSFARPLILGSGLVLRYYANLLKISVPLRSID 61

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
             +  Q      +++  ++L A    G+++   G    E L       L GE +A+ T P
Sbjct: 62  SPAEYQDGFVNYISVNNLSL-ADFEIGKVSPLCGRAAYEYLEAGIRMALRGEASAIATAP 120

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           ++K  ++ AG+ F GHTE   + +  K   MML    LRV   +TH+ LR   D +    
Sbjct: 121 LNKEALHRAGLEFAGHTEILAKLTGTKDYAMMLVAGNLRVMHVSTHVALRGACDMVKKER 180

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           ++  I  L        G+ +PRI V GLNPHAGEGG  G EEI  I P + + R QG+ +
Sbjct: 181 VY-KIVTLAATAAASLGVRDPRIAVAGLNPHAGEGGLFGDEEIYEIAPAVEKAREQGLSV 239

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GPLP DT+F        D V+AMYHDQG   +K  GF RGVN+T+GLP IRTSVDHGTA
Sbjct: 240 YGPLPPDTVFLKASRGEYDVVVAMYHDQGHIAVKMAGFERGVNVTVGLPIIRTSVDHGTA 299

Query: 301 LELAGRGKADVGSFITALNLAIKMIV 326
            ++AGRG AD  S + A+ LA +M+ 
Sbjct: 300 FDIAGRGIADERSMVEAVKLAAEMVK 325


>UniRef50_A1U6F9 4-hydroxythreonine-4-phosphate dehydrogenase n=125
           Tax=Proteobacteria RepID=PDXA_MARAV
          Length = 336

 Score =  424 bits (1091), Expect = e-117,   Method: Composition-based stats.
 Identities = 192/329 (58%), Positives = 234/329 (71%), Gaps = 1/329 (0%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M     + +T GEPAGIGP+L +QLA       LVV A   LL +RA+ LGL + L  + 
Sbjct: 1   MSTPVILALTAGEPAGIGPELCLQLATGSRDAGLVVIASGELLRDRASQLGLQIELHDWQ 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
               A    AG L++  V       AG+L   N  YV++TL  A  GCLNG+F  ++T P
Sbjct: 61  -PGVAAATRAGHLSVRHVEGCGSTVAGRLDKANSQYVLDTLTIAARGCLNGDFDGMVTAP 119

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           VHKGVIN+AGI F+GHTEF +E    ++VVMMLATEELRVAL TTHLPL+D++ AITP  
Sbjct: 120 VHKGVINEAGIVFSGHTEFLQELCGVERVVMMLATEELRVALVTTHLPLKDVSAAITPDR 179

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           L +V  IL+ DL+  FGI +PRILV GLNPHAGEGGH+G EEI+ I P L +LRA+G++L
Sbjct: 180 LTQVTRILNADLKAFFGIDQPRILVAGLNPHAGEGGHLGREEIEVIEPTLEQLRAEGIQL 239

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GPLPADTLF P +LDNADAVLAMYHDQGLPVLK+QGFGR VNITLGLP +RTSVDHGTA
Sbjct: 240 TGPLPADTLFTPHWLDNADAVLAMYHDQGLPVLKFQGFGRAVNITLGLPIVRTSVDHGTA 299

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNTQ 329
           L+LAG GKAD GS  TA+ +  +M    +
Sbjct: 300 LDLAGTGKADAGSLHTAIRVGEQMAQCRK 328


>UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic protein pdxA n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q0V0_9BACT
          Length = 346

 Score =  421 bits (1082), Expect = e-116,   Method: Composition-based stats.
 Identities = 120/332 (36%), Positives = 176/332 (53%), Gaps = 6/332 (1%)

Query: 1   MVKTQR--VVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLT 55
           + K  +  + IT G+P GIGP+++V+       +     ++  +  +L + A  L +P  
Sbjct: 10  INKKPKLLIGITMGDPCGIGPEIIVRSLASSALKRAANYIIIGNQAVLDSTAQSLKIPFR 69

Query: 56  LRPYSPNSPAQ-PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFA 114
            R  S  +  +   T  +L          +       E G      + +  D  L G+  
Sbjct: 70  YRVVSLETDIERVSTPISLLSSEHFDLNLIKKRLPTAEGGELSFLWIKKGIDLALQGKIN 129

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
           AL+T P+ K  I+ AG  + GHTE   + S+ K+VVM++    LRVA  TTH+ L ++A 
Sbjct: 130 ALVTAPICKEAIHMAGYQYPGHTEILRDLSKVKRVVMLMIGGSLRVAFVTTHIALHEVAQ 189

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
           +IT   + E I I +  L+  F    PRI VCG+NPHAGE G  G EE + I+P + + +
Sbjct: 190 SITVKNVLETITICNTYLKKYFTPRNPRIAVCGVNPHAGEEGIFGNEEKNIIVPAVKKAK 249

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
             G++ NGP+ ADT+F        D V++MYHDQG   LK   F  GVNITLG+PFIRTS
Sbjct: 250 KLGVECNGPVSADTVFYKALKGQYDLVVSMYHDQGAIPLKLHAFETGVNITLGIPFIRTS 309

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIV 326
            DHGTA ++AG+G A+  S   A+  AI M  
Sbjct: 310 PDHGTAYDIAGKGIANPDSMKEAIMTAIMMAK 341


>UniRef50_D1UTB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Burkholderia
           sp. CCGE1001 RepID=D1UTB0_9BURK
          Length = 784

 Score =  420 bits (1081), Expect = e-116,   Method: Composition-based stats.
 Identities = 125/333 (37%), Positives = 178/333 (53%), Gaps = 7/333 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLR 57
           M     + IT G+ AG+GP+++++             +V  D+  L +     G+ L++R
Sbjct: 449 MTYRPVIGITMGDAAGVGPEIIMKSLAHASVYDGCRPLVIGDSKRLVDAGQRTGVTLSVR 508

Query: 58  PYSPNSPAQPQTAGTLTLLPVAL-RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
           P +  + A+ Q  G +  + + L  A +  G+L+   G    + +AR  +    GE  A+
Sbjct: 509 PIASPAEARFQY-GEVDCIDLGLIPADLPYGKLSAVAGDAAYQYIARTVELTSAGELDAI 567

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  ++  G  F GHTE     +   +V MML   +LRV   TTH+ L D    I
Sbjct: 568 CTAPLNKEALHAGGHIFPGHTEMLAHLTGIPEVSMMLVAPKLRVIHVTTHIGLLDAIRRI 627

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRA 235
            P L+   I   H  L  + GI EPRI VCG+NPHAGE G  G  EE + I+P +  LR 
Sbjct: 628 EPGLVQRTIERAHETL-VRAGIDEPRIGVCGINPHAGENGLFGYGEEEEKIVPAVAVLRE 686

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G  + GPLPADTLF      + D V+AMYHDQG   +K  G   GVN+T+GLP IRTSV
Sbjct: 687 RGWDVEGPLPADTLFFRAGRGDFDVVVAMYHDQGHGPVKVMGLEAGVNVTVGLPVIRTSV 746

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           DHGTA ++AG+G AD  S + AL  A  +    
Sbjct: 747 DHGTAFDIAGKGIADERSMLEALKQAEDLATRR 779


>UniRef50_C5ELY2 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Bacteria
           RepID=C5ELY2_9FIRM
          Length = 358

 Score =  419 bits (1077), Expect = e-116,   Method: Composition-based stats.
 Identities = 118/345 (34%), Positives = 176/345 (51%), Gaps = 17/345 (4%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGL-PLTL 56
           M +   + IT G+PA IGP++ V+             +V  DA ++     ++G   + +
Sbjct: 1   MDERLIIGITMGDPASIGPEITVKALANNEIYDKCRPLVIGDAGVMEAAVKIVGKEDVRI 60

Query: 57  RPYSPNSPAQPQTAGT-LTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
            P      A  Q     +  + +     +  G+++V  G      + +     + GE   
Sbjct: 61  HPVHSVEEALFQAGTIDVYDMDLVDMDKLERGKVSVMAGEAAFRYVEKVIQMAMAGEVDG 120

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
            +T   +K  IN AG  ++GHTE + + +  KK  MMLA E +RV   +TH+ LR+  D 
Sbjct: 121 TVTNAFNKEAINMAGHHYSGHTEVYADMTGTKKYTMMLAHENIRVVHVSTHVSLREACDR 180

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           +    + EVI I +   R   G+ +PRI V GLNPH+GE G  G EEID IIP +   +A
Sbjct: 181 VKKDRVLEVIRIAYQACR-DLGLEQPRIGVAGLNPHSGENGLFGREEIDEIIPAIEAAKA 239

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGF-----------GRGVNI 284
           +G++  GP+P DT+F        D V+AMYHDQG   LK  GF             GVNI
Sbjct: 240 EGIQAEGPVPPDTIFSKARGGWYDMVVAMYHDQGHIPLKVIGFVYNQEQQKWDAVAGVNI 299

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           TLGLP +R SVDHGTA + AG+G A+  S I A++  I++  + +
Sbjct: 300 TLGLPIVRASVDHGTAFDQAGQGIANELSLINAIDYGIRLSKSNK 344


>UniRef50_C0QBU5 4-hydroxythreonine-4-phosphate dehydrogenase n=10
           Tax=Deltaproteobacteria RepID=PDXA_DESAH
          Length = 340

 Score =  417 bits (1074), Expect = e-115,   Method: Composition-based stats.
 Identities = 119/328 (36%), Positives = 178/328 (54%), Gaps = 7/328 (2%)

Query: 1   MVKT-QRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTL 56
           M      + IT G+P GIGP+++V      +       +V  D  ++     +    + +
Sbjct: 1   MTDNRPVIGITMGDPVGIGPEIIVSALDDPFVYTVCRPLVLGDEGVMERAIDLKSARMDV 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFA 114
                 +  +    GT+ ++P++    A + AG      G  +++ +    D  ++G+  
Sbjct: 61  HTTDTPAGGKY-CHGTMDIVPLSRLDAATLLAGHPTPGTGKAMIDYITTGVDLAMDGKIQ 119

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
           A+ T P+ K  +  AG  F GHTE   +R+   +V MM+A + LRV L T H+PL +++ 
Sbjct: 120 AIATCPITKTAMKLAGSKFHGHTELIADRTHTPRVAMMMAGDRLRVVLVTIHIPLCEVSA 179

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +  A +   I++    L+TKFGI EPRI V GLNPH GE G  G+EE++ I P + + R
Sbjct: 180 RLNQAEILATISLTSETLKTKFGIPEPRIAVAGLNPHGGEDGMFGSEELEIIAPAVEQAR 239

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           ++G+ ++GP P DTLF        DAV+ MYHDQGL   K   F  GVN TLGLP IRTS
Sbjct: 240 SKGITVSGPFPPDTLFFNAANHKFDAVVCMYHDQGLIPFKMIHFSDGVNTTLGLPIIRTS 299

Query: 295 VDHGTALELAGRGKADVGSFITALNLAI 322
           VDHGTA ++A RG AD  S I A+ +A 
Sbjct: 300 VDHGTAYDIAWRGTADPSSLIAAIKMAA 327


>UniRef50_B8FEI1 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Desulfatibacillum alkenivorans AK-01
           RepID=PDXA_DESAA
          Length = 333

 Score =  417 bits (1073), Expect = e-115,   Method: Composition-based stats.
 Identities = 125/334 (37%), Positives = 178/334 (53%), Gaps = 6/334 (1%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLR 57
           M     + IT G+P G+GP+++V+  + +        +V  D  ++    +++   L  R
Sbjct: 1   MKSLPIIGITMGDPVGVGPEIIVKTLKNKDIYKICRPLVIGDLKVMEQAESLIRSGLDFR 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
           P      A  +  G + +LPV+   P  +       + G  +V+ +  A D   +    A
Sbjct: 61  PAGSPEDAAYEY-GRVDILPVSDLDPARLAPKTPCAKTGEAMVKYITTAVDYARDNRIQA 119

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           + TGP+ K  ++ AG  F GHTE   +R+   K VMMLA ++LRV L T H+ + +I   
Sbjct: 120 VTTGPIQKAAVHAAGYTFAGHTELLAQRTGTSKYVMMLAGDKLRVVLVTIHMAVSEIPAH 179

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           +T     E + +    L+ +FGI +P++ V  LNPHAGE G  GTEE D IIP +   + 
Sbjct: 180 VTREKFIETVEVTGQALKERFGIPQPKMAVAALNPHAGEEGAFGTEERDVIIPAMEHFKG 239

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
             + L+GP PADTLF        DAV+ MYHDQGL   K   F  GVN TLGLP IRTSV
Sbjct: 240 SDIALDGPWPADTLFYHAQQGKWDAVVCMYHDQGLIPFKMIHFHDGVNTTLGLPIIRTSV 299

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           DHGTA +LAG GKAD GS   A+ +A     N +
Sbjct: 300 DHGTAYDLAGTGKADHGSMEAAIRMAALQASNLK 333


>UniRef50_B2U6L2 4-hydroxythreonine-4-phosphate dehydrogenase n=8 Tax=Proteobacteria
           RepID=B2U6L2_RALPJ
          Length = 770

 Score =  416 bits (1069), Expect = e-115,   Method: Composition-based stats.
 Identities = 123/333 (36%), Positives = 172/333 (51%), Gaps = 7/333 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLR 57
           M     + IT G+ AG+GP+++++             +V  D   L + A   G  L +R
Sbjct: 431 MTYRPVIGITMGDAAGVGPEIIMKALTHRAVYEQCRPLVIGDTARLRDAAQRTGAALEVR 490

Query: 58  PYSPNSPAQPQTAGTLTLLPVAL-RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
                + A  +  G +  + + L  A +  G+L+   G    + +AR  +    GE  A+
Sbjct: 491 SIERPADAAFRY-GVVDCIDLGLIPADLPYGKLSPIAGDAAYQYIARTVELTSAGELDAI 549

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  ++  G  F GHTE     +   +V MML    LRV   TTH+ L D    I
Sbjct: 550 CTAPLNKEALHAGGHIFPGHTEMLAHLTGIDEVSMMLVAPNLRVIHVTTHIGLLDAIRRI 609

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRA 235
            P L+   I   H  L  + GI  PRI VCG+NPHAGE G  G  EE   IIP +  L+A
Sbjct: 610 EPGLVQRTIERAHATL-VRAGIENPRIGVCGINPHAGENGLFGHGEEEQKIIPAVQVLQA 668

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G ++ GPLPADTLF      + D V+AMYHDQG   +K  G   GVN+T+GLP IRTSV
Sbjct: 669 RGWRVEGPLPADTLFFRAGRGDFDVVVAMYHDQGHGPVKVMGLEAGVNVTVGLPVIRTSV 728

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           DHGTA ++AG+G AD  S + A   A ++    
Sbjct: 729 DHGTAFDIAGKGIADERSMLEAFRQACELATRH 761


>UniRef50_Q89ZK3 4-hydroxythreonine-4-phosphate dehydrogenase n=33 Tax=Bacteroidales
           RepID=PDXA_BACTN
          Length = 364

 Score =  416 bits (1069), Expect = e-115,   Method: Composition-based stats.
 Identities = 112/331 (33%), Positives = 159/331 (48%), Gaps = 6/331 (1%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRPY 59
              R+ IT G+  G+G +++++             ++     +       L +       
Sbjct: 4   NKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPKVAAYHRKALDVQANFSIV 63

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
           +  S A       +          V   +   E G   +  L RA +    G    ++T 
Sbjct: 64  NTASEAGYNRLSVVNC--TDDEVKVEFSKPDPEAGKAALGALERAIEEYREGLIDVIVTA 121

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           P++K  I      F GHTE+ EER     K +M+L   + RVAL TTH+P+R+IA  IT 
Sbjct: 122 PINKHTIQSEEFSFPGHTEYIEERLGNGNKSLMILMKNDFRVALVTTHIPVREIATTITK 181

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
            L+ E + I H  L+  FGI  PRI V  LNPHAG+GG +G EE + IIP + E+  +G+
Sbjct: 182 ELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLGMEEQEIIIPAMKEMEEKGI 241

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
              GP  AD         + D +LAMYHDQGL   K      GVN T GLP +RTS  HG
Sbjct: 242 ICYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAMEDGVNYTAGLPVVRTSPAHG 301

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           TA ++AG+G A   SF  A+ +AI +  N Q
Sbjct: 302 TAYDIAGKGLASEDSFRQAIYVAIDVFRNRQ 332


>UniRef50_Q3IFD2 4-hydroxythreonine-4-phosphate dehydrogenase n=68
           Tax=Proteobacteria RepID=PDXA_PSEHT
          Length = 330

 Score =  415 bits (1068), Expect = e-115,   Method: Composition-based stats.
 Identities = 202/323 (62%), Positives = 243/323 (75%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
           R+ ITPGEPAGIGPDL+++LAQ+ W  +LV  ADA +L  RA  LGL + L  +  ++ A
Sbjct: 4   RIAITPGEPAGIGPDLLLKLAQQTWDAQLVAIADANMLKQRAKHLGLSIKLIEFDQHAAA 63

Query: 66  QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
            P  AG+L L  V +  PV  G L   NG YV++TL  A +  ++G FAA++TGPVHKG+
Sbjct: 64  TPAPAGSLYLHQVDVAEPVELGVLNDANGQYVLDTLRIASEKNMDGTFAAVVTGPVHKGI 123

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
           IN AGI F+GHTE+F ++S    VVMMLAT+ LRVAL TTH+PL  ++ AIT   L +V 
Sbjct: 124 INKAGISFSGHTEYFAQQSNTADVVMMLATQGLRVALVTTHIPLAYVSRAITEDRLIKVA 183

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
           +IL+HDL+TKFGI +PRILVCGLNPHAGE GH+G EEIDTIIP L  L  QGM L GPLP
Sbjct: 184 SILNHDLQTKFGIEKPRILVCGLNPHAGEDGHLGREEIDTIIPTLEILNNQGMNLIGPLP 243

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
           ADTLFQ KYL+ ADAVLAMYHDQGLPVLKY+GFG  VNITLGLPFIRTSVDHGTAL+LAG
Sbjct: 244 ADTLFQDKYLNEADAVLAMYHDQGLPVLKYKGFGNSVNITLGLPFIRTSVDHGTALDLAG 303

Query: 306 RGKADVGSFITALNLAIKMIVNT 328
           +G ADVGSF  A+  AIK+    
Sbjct: 304 KGTADVGSFELAIREAIKLAQEK 326


>UniRef50_B1B883 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Bacteria
           RepID=B1B883_CLOBO
          Length = 323

 Score =  412 bits (1059), Expect = e-113,   Method: Composition-based stats.
 Identities = 101/318 (31%), Positives = 168/318 (52%), Gaps = 4/318 (1%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVE--LVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           + IT G+PAGIG +++++   +        ++     ++     +L +   +      + 
Sbjct: 4   IGITMGDPAGIGAEIILKALDKYDEYRKKSIIFGSKDVMEFYRDILNVNAHINIIEDINE 63

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
                   +  + ++    +  GQ++   G    + +  +    LN +  A++T P++K 
Sbjct: 64  FNDSCINLVNCVDIS-MDDIKIGQVSGRCGDAAYKYVEESIKWALNKKIKAVVTTPLNKK 122

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
            ++     F GHTE F + +  KK  M+L +++L+V   +TH+ L +    +    + +V
Sbjct: 123 ALHLGNHNFDGHTEIFAKLTGTKKYAMLLWSDDLKVIHVSTHISLFNACKNVKKERIFDV 182

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL 244
           I + +   + K G+  PRI V GLNPHAGE G  GTEEI+ I P + E R +G+ ++GP+
Sbjct: 183 INLANDTFK-KMGVKNPRIAVAGLNPHAGEDGIFGTEEINEIGPAVEEARKRGINVHGPI 241

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELA 304
           P D +F   Y    D V+AMYHDQG   +K   F  GVNIT+GLP IRTSVDHGTA ++A
Sbjct: 242 PPDIVFLKAYNKEYDIVVAMYHDQGHIPMKLLEFDSGVNITVGLPIIRTSVDHGTAFDIA 301

Query: 305 GRGKADVGSFITALNLAI 322
           G   A+  S I A+ ++ 
Sbjct: 302 GNLVANDKSLIQAIKVSC 319


>UniRef50_A0JTQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=9 Tax=Bacteria
           RepID=A0JTQ9_ARTS2
          Length = 792

 Score =  411 bits (1058), Expect = e-113,   Method: Composition-based stats.
 Identities = 125/328 (38%), Positives = 174/328 (53%), Gaps = 7/328 (2%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPYSP 61
             V +T G+ AG+GP++VV              VV  DA  L   A +LG+   +     
Sbjct: 462 PIVAVTMGDGAGVGPEVVVAAVLDPQSNKECRPVVIGDALRLRQAADVLGIEADIHTIEK 521

Query: 62  NSPAQPQTAGTLTLLPVAL-RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
              A     G + ++ +AL    +  GQL+   GH   E +  A +  + G   A+ T P
Sbjct: 522 VEDAVFT-PGRVNVIDLALLPEDLPWGQLSPVAGHAAYEYIRVASELAMAGTVQAICTAP 580

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           ++K  ++ AG  F GHTE   + +  ++V MML+T ++RV   TTH+ L D    I P L
Sbjct: 581 LNKEALHAAGHIFPGHTELLAQLTGTEEVSMMLSTPKIRVIHVTTHIGLMDAIRKINPDL 640

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT-EEIDTIIPVLNELRAQGMK 239
           +   I   H  L  + GI  P+I VC +NPHAGE G  G  EE + I P +   +A G+ 
Sbjct: 641 VERTIRRGHEAL-VRAGIPNPKIGVCAINPHAGENGLFGQGEEAEKIEPGVKAAQAAGID 699

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           + GPLPADTLF      + D V+AMYHDQG   +K  G   GVNIT+GLP IRTSVDHGT
Sbjct: 700 VTGPLPADTLFFLAGRGDYDLVVAMYHDQGHGPVKVLGIEAGVNITVGLPVIRTSVDHGT 759

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVN 327
           A ++AG+  AD  S + AL+ A +M   
Sbjct: 760 AFDIAGKAIADPRSMVEALHQAAEMATR 787


>UniRef50_A0LIN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Syntrophobacter fumaroxidans MPOB RepID=PDXA_SYNFM
          Length = 345

 Score =  410 bits (1055), Expect = e-113,   Method: Composition-based stats.
 Identities = 127/333 (38%), Positives = 174/333 (52%), Gaps = 7/333 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRPY 59
              R+ +T G+P G+GPD++ Q             +V  D + L    A+ G    +   
Sbjct: 4   SKPRIALTMGDPCGVGPDVIAQALASPTLFECCTPIVVGDPSALQRSMALSGASKKVLVL 63

Query: 60  SPNSPA--QPQTAGTLTLLPVALRA-PVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
              +     P +     + PV L    +  G+        VV  +  A    L G+   +
Sbjct: 64  REPAELPDDPGSDRIPLIAPVELSGRDIEHGRPTAATCGAVVRYIESAVAFALAGQVRGV 123

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            TGP++K  +++ G  F GHTEF +  + +++VVMMLA   LRV+LAT H  L D+   +
Sbjct: 124 CTGPINKARMHEHGFDFPGHTEFLQALTGSRRVVMMLAGPRLRVSLATIHEALADVPALL 183

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
              +L EVI I    L   FG+  PR+ V GLNPHAGE G  G EEI+ + P +  LR  
Sbjct: 184 NVEMLREVIRITAEALIRDFGLQAPRLAVAGLNPHAGEEGRFGREEIEILRPAIESLRPP 243

Query: 237 G-MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           G   + GP PADTLFQ  +    DAV+AMYHDQGL  +K   F   VN++LGLP +RTSV
Sbjct: 244 GRCTVTGPYPADTLFQRAHAGEFDAVVAMYHDQGLVPIKLVHFYDAVNVSLGLPIVRTSV 303

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           DHGTA +LAG G+A  GS   A+ LA  M  N 
Sbjct: 304 DHGTAYDLAGTGRAHPGSLTAAVQLAALMAHNR 336


>UniRef50_Q2S3U3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Rhodothermaceae RepID=Q2S3U3_SALRD
          Length = 402

 Score =  410 bits (1055), Expect = e-113,   Method: Composition-based stats.
 Identities = 115/329 (34%), Positives = 166/329 (50%), Gaps = 4/329 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGL-PLTLRPY 59
             R+ IT G+P GIGP++V++       +     V+   A +L   A +LG   L +   
Sbjct: 66  PTRLAITLGDPNGIGPEVVLKSLHDPSLMPSMTPVLIGSAHVLRVHADVLGFSDLDIHIV 125

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
                  P     +  +      PV  G +  E G   +  + RA + C  G   A++T 
Sbjct: 126 DEVPEEVPHGDVAVLDVAEDPEPPVMFGSITAEGGRLAMRAVERAVEACQAGTVDAMVTA 185

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P+ K  +   G    GHTEF  +++ + +  MM+    LRV L T+H  L ++  A+T  
Sbjct: 186 PISKDAVRQGGYDVPGHTEFLADKTNSPQPTMMMVAGGLRVGLVTSHTALSEVPSAVTEE 245

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            + E + ++   LR  F I +P+I V GLNPHAGE G  G EE + I P L   R +G +
Sbjct: 246 AILEKLRVIDASLRDDFAIEQPKIAVFGLNPHAGEAGAFGQEEEEVIAPALRAARQEGFR 305

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           + GP+ AD  F  +   + DA LAMYHDQGL   K   F  GVN T GLP +RTS DHGT
Sbjct: 306 VEGPMAADGFFGTQLDADHDAALAMYHDQGLVPFKALAFDHGVNYTAGLPIVRTSPDHGT 365

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           A  +AG+G A  GS   A+ LA+ +  + 
Sbjct: 366 AYGIAGKGMALPGSMRNAMELAVAIARHR 394


>UniRef50_B2V9E6 4-hydroxythreonine-4-phosphate dehydrogenase n=5 Tax=Aquificales
           RepID=PDXA_SULSY
          Length = 322

 Score =  409 bits (1051), Expect = e-112,   Method: Composition-based stats.
 Identities = 114/326 (34%), Positives = 179/326 (54%), Gaps = 8/326 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           ++ IT G+P+GI  +++++   +  +  +  V+      L     + G+ L ++     +
Sbjct: 3   KLAITLGDPSGINSEILLKALNKLPKRNISYVIYGSKKALEKAKKLTGVDLNIKEIKSIN 62

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
                    + L  +     V  G  + E G   V  L  A    L  +  ALIT P+ K
Sbjct: 63  DVVKSGIYLINLYDLD----VEFGSSSKETGKASVVYLENAVKDVLEKKADALITLPISK 118

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             I ++G P+ GHT++  E S AK+  M+L  ++L+VAL TTH+PL+D+   IT   +  
Sbjct: 119 QWIMESGFPYAGHTDYLAEVSGAKEYAMVLMCKKLKVALITTHIPLKDVPSQITKEKIIS 178

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            + +++ + + KFGI++P+I + GLNPHA + G++G EE + I+P +  LR  G+++  P
Sbjct: 179 KVRLINREFKEKFGISKPKIAILGLNPHASDNGNIGNEEQNIILPAVKTLREDGIEITDP 238

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           L  DT F      + D  +AMYHDQGL  LK   F + VNITLGLPFIRTS DHGT  ++
Sbjct: 239 LSPDTAFNR--YKDFDIYVAMYHDQGLIPLKLLCFRKAVNITLGLPFIRTSPDHGTGYDI 296

Query: 304 AGRGKADVGSFITALNLAIKMIVNTQ 329
           AG+  AD  S I A+ LAI +    +
Sbjct: 297 AGKNIADPSSTIEAVELAILLKRVRK 322


>UniRef50_P58718 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=29 Tax=Bacteria
           RepID=PDXA2_SALTY
          Length = 327

 Score =  406 bits (1043), Expect = e-112,   Method: Composition-based stats.
 Identities = 121/329 (36%), Positives = 181/329 (55%), Gaps = 7/329 (2%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWP--VELVVCADATLLTN-RAAMLGLPLTLRP 58
           ++T+ V IT G+PAGIGP+++V+    +      LVV      L   +A  +   + LR 
Sbjct: 1   METKTVAITMGDPAGIGPEIIVKALSEDGLNGAPLVVIGCLATLKRLQAKGITPNVELRA 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
               + A+    G + ++   L  P  + AG++  + G      + RA +  L G+  A+
Sbjct: 61  IERVAEARF-APGIIHVIDEPLAQPEALEAGKVQAQAGDLAYRCVKRATELALRGDVQAI 119

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  ++ AG  + GHTE     + ++   M+L T++L+V   +TH+ LR   D +
Sbjct: 120 ATAPLNKEALHLAGHNYPGHTELLATLTHSRDYAMVLYTDKLKVIHVSTHIALRKFLDTL 179

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           + A +  VI I    L+ + G  +PRI V G+NPHAGE G  G EE   + P + + RA+
Sbjct: 180 STARVETVIGIADTFLK-RVGYVKPRIAVAGVNPHAGENGLFGDEETRILTPAITDARAK 238

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           GM + GP P DT+F   Y    D V+AMYHDQG   LK  GF  GVNIT GLPFIRTS D
Sbjct: 239 GMDVYGPCPPDTVFLQAYEGQYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSAD 298

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMI 325
           HGTA ++A  GKA   S   ++ LA+++ 
Sbjct: 299 HGTAFDIAWTGKAKSESMAVSIKLAMQLA 327


>UniRef50_A3ERM0 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Leptospirillum
           RepID=A3ERM0_9BACT
          Length = 344

 Score =  403 bits (1037), Expect = e-111,   Method: Composition-based stats.
 Identities = 119/327 (36%), Positives = 171/327 (52%), Gaps = 5/327 (1%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVEL--VVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            + IT G+PAGIGP+++V+        +L  +V  D  L+   A      L ++      
Sbjct: 14  PLAITMGDPAGIGPEIIVKGWLENEIRDLPRIVIGDPDLIAEVARKYSPELLVQQIDSPE 73

Query: 64  PA--QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            A   P   G L      +  PV+ G   V  G +    +    +  + G  A ++T P+
Sbjct: 74  HAPRDPGILGVLLPEHEDILEPVSPGTSQVMAGRWAYYCVRTGVELAMAGRVAGIVTAPL 133

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           +K V++ AG  + GHTE     +   +  MML    L+V L TTH+P R+IA  IT   +
Sbjct: 134 NKKVLHAAGFNYPGHTELIAHLTNTPRYGMMLVGGPLKVILVTTHIPFREIAGKITKERV 193

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
            E I +    +     IA P+I V  LNPHAGE    G EE   I P + E RA+G+++ 
Sbjct: 194 LETIQLAREAMDM-LKIASPKIAVAALNPHAGEASLFGDEEKTCIFPAILEARAEGIEVE 252

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GPLPADTL+        D V++ YHDQGL  LK   FG+G+N+T+G+P IRTSVDHGTA 
Sbjct: 253 GPLPADTLYAKAAQGRFDIVVSQYHDQGLIPLKMLSFGQGINVTVGIPIIRTSVDHGTAY 312

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNT 328
           ++ G+G A  GS I A+ LA ++    
Sbjct: 313 DIVGKGIAQPGSLIKAIRLAGQLTEGR 339


>UniRef50_C8QYR8 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QYR8_9DELT
          Length = 342

 Score =  402 bits (1035), Expect = e-111,   Method: Composition-based stats.
 Identities = 124/337 (36%), Positives = 177/337 (52%), Gaps = 22/337 (6%)

Query: 11  PGEPAGIGPDLVVQLAQREWPVE---------------LVVCADATLLTNRAAMLGLPLT 55
            G PAG+GP+++++L                        VV  D  +L   A  LG+ + 
Sbjct: 1   MGCPAGVGPEIILRLHLEREQARQAGTTETGRQEPAAAAVVLGDLGVLAQCARQLGVKVE 60

Query: 56  LRPYSPNSPAQPQTAGTLTLLPVALRAPVT-AGQLAVENGHYVVETLARACDGCLNGEFA 114
           L P+ P    QP  +G L +LPV   AP+   G+  V +G  + E + +A     +GE A
Sbjct: 61  LNPWQP---GQPLGSGALNVLPVTSLAPLPSPGRPTVASGRAMGEYIEQAVALAQSGELA 117

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
           A++T P+ K ++N  G  + GHTE         +  MM+A   LRV+L + H PL  + +
Sbjct: 118 AMVTCPIGKDMLNAGGYHYPGHTEMLATLCNCSEYAMMMAGARLRVSLVSIHRPLSRVPE 177

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
           A+T   +  +I +    L+  F +  PR+ V  LNPHAGEGG  G EE   I P + +  
Sbjct: 178 AVTQEAVVRLIRLTARSLQHDFAVLRPRLAVAALNPHAGEGGMFGDEEKRVIEPAVAQAA 237

Query: 235 A---QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFI 291
           A   + + ++GP P DT+F      + DAV+AMYHDQGL   K   F  GVN+T+GLP I
Sbjct: 238 ALLGREVSISGPRPPDTVFYQASQGDFDAVVAMYHDQGLIPFKLLHFKDGVNVTIGLPII 297

Query: 292 RTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           RTSVDHGTA ++AGRG AD  S   A  LA ++  N 
Sbjct: 298 RTSVDHGTAYDIAGRGVADHDSLRAAFWLAAEIAANR 334


>UniRef50_B7UKV9 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=15
           Tax=Enterobacteriaceae RepID=B7UKV9_ECO27
          Length = 328

 Score =  401 bits (1032), Expect = e-110,   Method: Composition-based stats.
 Identities = 117/326 (35%), Positives = 173/326 (53%), Gaps = 7/326 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPV--ELVVCADATLLTNRAAM-LGLPLTLRPYSPN 62
            + +T G+PAGIGP+++++           +VV      L    AM +     LR     
Sbjct: 4   IIAVTMGDPAGIGPEIIIKSLSEAGLAGTPVVVVGCVRTLRRIMAMNITPQAELRVIQKV 63

Query: 63  SPAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
             A     G + ++   L  P  +T G +    G      + RA    L+GE  A+ T P
Sbjct: 64  CDAHF-APGVINVMDEPLANPDALTPGVVQAAAGDLAYRCIKRATALALSGEVKAIATAP 122

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           ++K  ++  G  + GHTE     + +K+  M+L T++L+V   +TH+ LR   D +    
Sbjct: 123 LNKEALHLGGHNYPGHTELLAHLTGSKEYAMVLYTDKLKVIHISTHISLRKFLDTLNGER 182

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +  VI + +H L+ + GI  PRI V G+NPHAGE G  GTEEI+ I P +  ++A+ + +
Sbjct: 183 VKTVIRVANHFLK-RVGIERPRIAVAGVNPHAGEHGLFGTEEIEIIAPAIEAMQAEDIDV 241

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP P DT+F   +    D V+AMYHDQG   LK  GF  GVNIT GLPFIRTS DHGTA
Sbjct: 242 TGPCPPDTVFMQCHEGLFDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHGTA 301

Query: 301 LELAGRGKADVGSFITALNLAIKMIV 326
            ++A  GKA   S   ++ LA+++  
Sbjct: 302 FDIAWTGKAKSESMAVSIQLAMQISR 327


>UniRef50_C7R7U0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Kangiella
           koreensis DSM 16069 RepID=C7R7U0_KANKD
          Length = 332

 Score =  401 bits (1032), Expect = e-110,   Method: Composition-based stats.
 Identities = 186/330 (56%), Positives = 243/330 (73%), Gaps = 1/330 (0%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M++  R++IT GEPAGIGP+++V+LAQ     +L+ CA  TLL + A  L LPL L  ++
Sbjct: 1   MIQPARILITAGEPAGIGPEIIVKLAQEPCSDQLIACASPTLLKDTAQQLHLPLELSVFN 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            N  A     G L ++PV L +PV AG+L   N  YV++TL  A    +NG   A++TGP
Sbjct: 61  TNEEALAHRIGHLWIVPVELESPVIAGKLNQTNAAYVIKTLDTAHQLAINGAVNAILTGP 120

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           VHKG+IN +G+ FTGHTEFF ++S A KVVMMLATE LRVALATTHLPL++++ A+TP L
Sbjct: 121 VHKGIINQSGLAFTGHTEFFADKSNAHKVVMMLATEGLRVALATTHLPLKEVSGAVTPQL 180

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG-MK 239
           L EVI IL H+L++KF +  P++LVCGLNPHAGE GH+G EE+DTIIP L ++R Q   +
Sbjct: 181 LQEVIEILIHELQSKFSLKRPKVLVCGLNPHAGEDGHLGREEVDTIIPTLEKMRTQFDAE 240

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           L GP+PADT FQPK+L   D VLAMYHDQGLP LKY+GFG+ +N+TLGLP+IRTSVDHGT
Sbjct: 241 LIGPIPADTAFQPKWLTQVDTVLAMYHDQGLPTLKYKGFGKAINLTLGLPYIRTSVDHGT 300

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNTQ 329
            L++AG+G AD+GS   AL    ++I N +
Sbjct: 301 GLDIAGQGLADIGSMHYALQFTQQLINNRK 330


>UniRef50_Q1NMK1 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Proteobacteria
           RepID=Q1NMK1_9DELT
          Length = 340

 Score =  401 bits (1031), Expect = e-110,   Method: Composition-based stats.
 Identities = 130/333 (39%), Positives = 174/333 (52%), Gaps = 11/333 (3%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQR----EWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
              + IT G PAGIGP+++++             LVV  D  +L + A  LG  + LR +
Sbjct: 7   PPPIGITMGCPAGIGPEIILRFWSELATAGQRRSLVVLGDPGVLAHNARQLGFKVPLRVW 66

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
            P     P     L +    L AP   G+   E+G  +   +  AC   + GE  A++T 
Sbjct: 67  HPQEAPNPAALNILPV--SELSAPPPWGRPTPESGRAMGRYIVEACRLAMGGELTAMVTC 124

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P+ K ++N  G  + GHTE      ++ +  MM+A   LRV LAT H PL  +  A+ PA
Sbjct: 125 PIGKEMLNAGGYHYPGHTEMLAALCKSPEYAMMMAGHRLRVVLATIHCPLTAVPAALEPA 184

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTI----IPVLNELRA 235
            LH ++ +    LR  F I  PR+ V GLNPHAGEGG  G EE   I         EL  
Sbjct: 185 KLHHLLRLTVAALRRDFAIPAPRLAVAGLNPHAGEGGMFGHEEKTVIAPAVAAAAAELGG 244

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G +L GP P DT+F      + DAV+AMYHDQGL   K   F  GVN+TLGLP +RTSV
Sbjct: 245 KG-ELVGPRPPDTVFHQAAAGHFDAVVAMYHDQGLIPFKLLHFSDGVNVTLGLPVVRTSV 303

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           DHGTA ++AGRG AD  S   A  LA ++  + 
Sbjct: 304 DHGTAYDIAGRGLADPASLAAAFQLATEIAAHR 336


>UniRef50_C9LG48 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Bacteroidales
           RepID=C9LG48_9BACT
          Length = 386

 Score =  399 bits (1027), Expect = e-110,   Method: Composition-based stats.
 Identities = 118/327 (36%), Positives = 163/327 (49%), Gaps = 6/327 (1%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           +V IT G+  G+G +L+ Q             +V     +       LGL    +    +
Sbjct: 27  KVGITHGDTNGVGYELIFQTFGNPTMFEMCTPIVYGSPQIANAHKKALGLQFNYQIIEDS 86

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
           + A       +  +      PV  GQ     G      L RA      G+   L+T P+ 
Sbjct: 87  ARAVDGQLNLIDCVKKD--VPVNLGQPDKAAGFAAYCALERATADLREGKIDVLVTAPID 144

Query: 123 KGVINDAGIPFTGHTEFFEERSQAK-KVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           K  I      FTGHTE+ ++R Q + + +M+L   +LRVAL TTHLPL ++A AIT   +
Sbjct: 145 KFTIQSDDFHFTGHTEYLQDRLQGEYEPLMILMNGQLRVALVTTHLPLSEVAPAITAERV 204

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
              + +L   LRT F +  PRI V  LNPH G+ G +G+EE + I PV+ +L  +G  + 
Sbjct: 205 ELKLRLLQRSLRTDFLLPMPRIAVLSLNPHCGDKGTIGSEEANIIKPVIEKLVKEGKNVF 264

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP PAD  F  +     DAVLAMYHDQGL   K      GVN T GL  +RTS DHG A 
Sbjct: 265 GPYPADGFFGSELHRRFDAVLAMYHDQGLAPFKALAMEEGVNFTAGLSAVRTSPDHGVAY 324

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNT 328
           ++AG+G A V SF +A+  AI +  N 
Sbjct: 325 DIAGKGVASVASFRSAVYSAIDIYRNR 351


>UniRef50_A6L8G2 4-hydroxythreonine-4-phosphate dehydrogenase n=7 Tax=Bacteroidales
           RepID=A6L8G2_PARD8
          Length = 369

 Score =  399 bits (1025), Expect = e-109,   Method: Composition-based stats.
 Identities = 110/329 (33%), Positives = 157/329 (47%), Gaps = 8/329 (2%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLP-LTLRPYSP 61
           +V IT G+  GIG +++++        E    ++   + +       L LP + +   S 
Sbjct: 7   KVGITHGDINGIGYEVILKTFSDTRMAELCTPIIYGSSKIAAYHRKALELPPINMNIISH 66

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
              A       +    V     V   +     G    + L  A      G    L+T P+
Sbjct: 67  AEDAGVNRVNIINC--VEDETKVELSKSTPVAGESAFKALEAAVTDMKRGVVDVLLTAPI 124

Query: 122 HKGVINDAGIPFTGHTEFFEERSQA--KKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           +K  I +    F GHTE+ E+      KK +M+L  ++LRVAL T H+PL  +A ++   
Sbjct: 125 NKHNIQNEDFHFPGHTEYLEKCFGGLDKKALMILMKDDLRVALVTGHIPLSQVASSLNVG 184

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +   + I +  L+  FGI +PRI V  LNPHAG+ G +GTEE   IIP + E   +G+ 
Sbjct: 185 DIVNKLRIFNQSLKQDFGIVKPRIAVLSLNPHAGDAGLLGTEEETIIIPAMQEAEKKGVM 244

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
             GP  AD  F  +  D  D VLAMYHDQGL   K      GVN T GLP +RTS  HGT
Sbjct: 245 SFGPYAADGFFGSQMYDKFDGVLAMYHDQGLAPFKTLAMDDGVNYTAGLPIVRTSPAHGT 304

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           A ++AG+  A   SF  AL  A+ +  N 
Sbjct: 305 AYDIAGQNVASEESFRQALYAALDIFRNR 333


>UniRef50_A6DS02 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Lentisphaerae
           RepID=A6DS02_9BACT
          Length = 326

 Score =  398 bits (1024), Expect = e-109,   Method: Composition-based stats.
 Identities = 119/329 (36%), Positives = 182/329 (55%), Gaps = 5/329 (1%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRP 58
           M+K + +++T G+PAG+GP++ V+   +        V+  DA +L+    +      L+P
Sbjct: 1   MMKNKAMILTSGDPAGVGPEVAVKAFAKLANEKFPFVIAGDAYVLSEAIELYAPEFKLKP 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
           Y P    +           +A  +     + + + G    + +  A    +  +++A++T
Sbjct: 61  YIPGEWEE--GVVYYDDFGLAFESSYEKCKASAQCGQLSYDLIVEATHAVIAKQYSAIVT 118

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            PV+K  +N AGI F+GHTE   E  +  +  MM + + LR   AT H+ L+++  A+T 
Sbjct: 119 APVNKESVNLAGITFSGHTELIAELCECPEFNMMQSADRLRCVFATCHIALKEVPKALTV 178

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + +   +LH     + G+ +P++   GLNPHAGE G+MG EEI+T+IP L  LR++G+
Sbjct: 179 DKILQAGRLLHQACLAE-GLVKPKLSAAGLNPHAGENGYMGREEIETVIPALEILRSEGI 237

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            + GP P DTLF P   +  +  L MYHDQG    K   F RGVN TLGLP IRTSVDHG
Sbjct: 238 DIEGPFPPDTLFVPAIRERFEGFLCMYHDQGHIPFKMLAFDRGVNSTLGLPIIRTSVDHG 297

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVN 327
           TA ++A + KAD+GS   AL LA K   N
Sbjct: 298 TAFDIAWQNKADIGSLENALKLAWKRTGN 326


>UniRef50_C6E7W5 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Geobacter
           RepID=C6E7W5_GEOSM
          Length = 348

 Score =  398 bits (1023), Expect = e-109,   Method: Composition-based stats.
 Identities = 119/316 (37%), Positives = 153/316 (48%), Gaps = 6/316 (1%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPY 59
               + +T G+P GIGP+++               +V  D   +    A+ G+ L +   
Sbjct: 16  DKPVIAVTMGDPCGIGPEIIAAALADPAITSLCRPLVIGDREAMERGIAVAGVKLAVASA 75

Query: 60  SPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
               P      GTL L  ++      +  G      G      +  A   CL+G   A+ 
Sbjct: 76  PDLLPPAIVAPGTLYLRELSRLKLDEIPYGAPTTAGGDACYRYICEAARLCLDGTAQAMA 135

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           T P++K  +N AG  + GHTE   E +   +VVMMLA E LRV L T H PL  + + +T
Sbjct: 136 TAPINKESMNSAGHDYPGHTELLAELTGTPEVVMMLAGERLRVTLVTIHEPLARVPELVT 195

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              +   I I H  L   F    PR+ V  LNPH GEGG  G EE   I P +   R  G
Sbjct: 196 FDRVLSTIRITHDALSRWF-CRAPRLAVLALNPHCGEGGMFGDEESRIIAPAVAAAREAG 254

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           +   GP+ ADTLF        DAV+ MYHDQGL  LK   F  GVN+TLGLP IRTSVDH
Sbjct: 255 IDAAGPVSADTLFHFAAKGGYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDH 314

Query: 298 GTALELAGRGKADVGS 313
           GTA +LAG GKA   S
Sbjct: 315 GTAYDLAGTGKASAES 330


>UniRef50_C7PP38 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Bacteria
           RepID=C7PP38_CHIPD
          Length = 354

 Score =  397 bits (1020), Expect = e-109,   Method: Composition-based stats.
 Identities = 102/332 (30%), Positives = 151/332 (45%), Gaps = 6/332 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLG-LPLTLR 57
                + IT G+   IG +L+++             V+ A    +     ++       +
Sbjct: 7   TNKPVIGITVGDINSIGTELIIKTFADARMLEFCTPVIFASNKTINFYRKLMNENNFNYQ 66

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                +    +               +T G L    G Y   +LA A +    G    LI
Sbjct: 67  SVKEFARLNHKQVNVFNCW--EEEVQITPGVLNEVGGKYAARSLAVAIECLKEGHIQGLI 124

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           T P+HK  I      +TGHT +  +   AK V+M +  + +RV L T H+P+ +I+  + 
Sbjct: 125 TAPIHKKNIQGEQFNYTGHTPYLRDAFDAKDVLMFMTADNMRVGLLTEHVPVAEISKYVK 184

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              +   + ++   L   FGI  PRI V GLNPHAG+ G +G EEI  IIP +   +  G
Sbjct: 185 KDNILAKLQMMEDSLIKDFGIDSPRIAVLGLNPHAGDDGLIGQEEITEIIPAIKHAKNNG 244

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           +   GP  AD  F     +  D VLAMYHDQGL   K    G G+N T GLP +RTS DH
Sbjct: 245 LLCFGPYSADAFFARNMHEQFDGVLAMYHDQGLIPFKSLATGNGINYTAGLPIVRTSPDH 304

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           GTA ++AG+  AD  SF  A+   + ++   +
Sbjct: 305 GTAFDIAGKNLADHNSFRQAIFTCLDILEKRE 336


>UniRef50_C7M3J3 4-hydroxythreonine-4-phosphate dehydrogenase n=6 Tax=Flavobacteria
           RepID=C7M3J3_CAPOD
          Length = 352

 Score =  396 bits (1018), Expect = e-109,   Method: Composition-based stats.
 Identities = 104/334 (31%), Positives = 164/334 (49%), Gaps = 8/334 (2%)

Query: 1   MVKTQ-RVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTL 56
           M +   +V I+ G+  G+G +++++  +          ++ A   L++ +          
Sbjct: 1   MKEKPIKVGISIGDMNGVGLEIILKTFEDHQILELCTPIIFASNKLVSFQKKHFNTTANF 60

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
           +       A       L          VT GQ   E G Y   +L  A +   N     L
Sbjct: 61  QGIESVEAAIDGKLNVLNCW--KETPTVTFGQETEEGGKYAFLSLQAAVEALKNNSIDVL 118

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
           +T P++K  I      F GHT++  +       +M + +E+L+V L T H+PL++++  I
Sbjct: 119 VTAPINKNNIQSDAFHFPGHTDYLAQELNGT-SLMFMVSEDLKVGLLTDHVPLKEVSSLI 177

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL-RA 235
           T AL+ E   +++  L   F +  P+I V G+NPH G+ G +G E+ + + P L +L   
Sbjct: 178 TEALIMEKARLMNESLIKDFRLQRPKIAVLGINPHCGDKGVIGNEDDEVLRPALKKLYFD 237

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           + + + GP  AD+ F  +   N DAVLA YHDQGL   K   FG GVN T GL  +RTS 
Sbjct: 238 ENILVFGPFAADSFFGSQTYRNYDAVLAPYHDQGLIAFKTIAFGSGVNYTAGLSKVRTSP 297

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           DHGTA E+AG+G AD  SF  A+  A+ +  N +
Sbjct: 298 DHGTAYEIAGKGIADPESFRHAIFTALDVFRNRE 331


>UniRef50_B2IDU5 4-hydroxythreonine-4-phosphate dehydrogenase n=29 Tax=cellular
           organisms RepID=PDXA_BEII9
          Length = 337

 Score =  396 bits (1018), Expect = e-109,   Method: Composition-based stats.
 Identities = 123/321 (38%), Positives = 177/321 (55%), Gaps = 4/321 (1%)

Query: 6   RVVITPGEPAGIGPDLVVQL-AQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
            + +T G+P+GIGP+++ ++  +R      +V  D  ++ +  A LG+ + +R  +    
Sbjct: 7   PLAVTMGDPSGIGPEIIAKMYLRRPDKRNWIVVGDPLVMEHAIANLGVAVQIRRIATVEE 66

Query: 65  AQPQTAGTLTLLPVALRAPVTA-GQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
           A  +  G L +L  +  A + A G+++  +G    + +  A      G    ++T P+HK
Sbjct: 67  AGCED-GVLNVLASSSLATLPAVGRVSAVSGQAAYDAIVTAIGLARQGTIRGIVTAPIHK 125

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             +  AGI + GHTE   E+  A+ V MMLA +E+R  L T H  L D           +
Sbjct: 126 EALAAAGIHYPGHTEILAEQGGAQHVAMMLANDEIRTVLVTIHCSLADAIRKADFPAQMQ 185

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            I + H   R   GI +PRI V GLNPHAGEGG  G EEI  I P +   RA+G+   GP
Sbjct: 186 AIRLAHEGARA-LGIVQPRIAVAGLNPHAGEGGLFGDEEIRIITPAIAAARAEGIDATGP 244

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
            P DT+F    L   D V+A YHDQGL  +K+ G  +GVNITLGLPF+RTS DHGTA ++
Sbjct: 245 WPGDTVFMQARLGKFDVVVAQYHDQGLIPVKFMGLEKGVNITLGLPFVRTSPDHGTAFDI 304

Query: 304 AGRGKADVGSFITALNLAIKM 324
           AGRG AD  S  TA + A ++
Sbjct: 305 AGRGIADSSSLETAFDYATRL 325


>UniRef50_C4X874 4-hydroxythreonine-4-phosphate dehydrogenase n=15 Tax=Bacteria
           RepID=C4X874_KLEPN
          Length = 328

 Score =  396 bits (1018), Expect = e-109,   Method: Composition-based stats.
 Identities = 120/328 (36%), Positives = 174/328 (53%), Gaps = 7/328 (2%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQRE--WPVELVVCADATLLTNRAAM-LGLPLTLRPYS 60
           ++ + +T G+PAGIGP+++++           +VV   A  L    A+ +     LR   
Sbjct: 2   SKMIAVTMGDPAGIGPEIIIKSLAEGALSGAPVVVVGCAQTLRRILALNITPRAELRIID 61

Query: 61  PNSPAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
             + A    A T+ ++   L  P  +  G++  + G      + RA    L G  AA+ T
Sbjct: 62  HPAEASFSPA-TINVIDEPLSDPQGLRPGEVQAQAGDLAFRCIRRATALALEGAVAAIAT 120

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P++K  ++ AG  + GHTE     +Q     M+L TE+L+V   TTH+ LR   D +  
Sbjct: 121 APLNKEALHLAGHAYPGHTELLAHLTQTTDYAMVLYTEKLKVIHITTHISLRQFLDTLNQ 180

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             +  VI +    LR + G   PRI V G+NPHAGE G  G EEI  + P +  +RA+G+
Sbjct: 181 PRIETVIGVADRFLR-RVGYPRPRIAVAGVNPHAGENGLFGDEEIRIVAPAVAAMRAKGV 239

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           ++ GP P DT+F   +    D V+AMYHDQG   LK  GF  GVNIT GLPFIRTS DHG
Sbjct: 240 EVTGPCPPDTVFMQCHEGMYDMVVAMYHDQGHIPLKLLGFYDGVNITAGLPFIRTSADHG 299

Query: 299 TALELAGRGKADVGSFITALNLAIKMIV 326
           TA ++A  GKA   S  T++ LA+ +  
Sbjct: 300 TAFDIAWTGKAKSESMATSIELAMHIAQ 327


>UniRef50_Q87ST5 4-hydroxythreonine-4-phosphate dehydrogenase n=34 Tax=Bacteria
           RepID=PDXA_VIBPA
          Length = 332

 Score =  394 bits (1014), Expect = e-108,   Method: Composition-based stats.
 Identities = 199/329 (60%), Positives = 244/329 (74%), Gaps = 1/329 (0%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
              +R+V+T GEPAGIGPDLV+ L++ +W  ++VVCAD  +L  RA MLG+ + L  Y+P
Sbjct: 4   NSIRRIVVTAGEPAGIGPDLVLALSKEDWAHQIVVCADKNMLLERAKMLGIDVQLFDYNP 63

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
               + Q AGTL +  V +     AGQL   NGHYV++TL RA  GC+N EF A++TGPV
Sbjct: 64  EEAPKAQKAGTLIVDHVEIAENAIAGQLNEANGHYVLKTLERAALGCMNDEFDAIVTGPV 123

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           HKGVIN AG+ F+GHTEFF E+S    VVMMLATE LRVAL TTH+PL  ++ A+T   L
Sbjct: 124 HKGVINRAGVAFSGHTEFFAEKSNTPLVVMMLATEGLRVALVTTHIPLAYVSKAVTEERL 183

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ-GMKL 240
            ++I ILH DL  KF IAEP I VCGLNPHAGE G +G EEI+TI P L +++ + G+KL
Sbjct: 184 EKIIDILHKDLVEKFAIAEPNIYVCGLNPHAGEDGCLGREEIETITPTLEKIQKEKGIKL 243

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GPLPADT+F  KYL++ADAVL MYHDQ LPVLKY+GFGR VNITLGLPFIRTSVDHGTA
Sbjct: 244 IGPLPADTIFNEKYLNDADAVLGMYHDQVLPVLKYKGFGRSVNITLGLPFIRTSVDHGTA 303

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNTQ 329
           LELAG G+AD GSF TAL  AI+++   Q
Sbjct: 304 LELAGTGQADTGSFRTALTHAIELVEKKQ 332


>UniRef50_Q89NF3 4-hydroxythreonine-4-phosphate dehydrogenase 1 n=8
           Tax=Proteobacteria RepID=PDXA1_BRAJA
          Length = 345

 Score =  392 bits (1007), Expect = e-107,   Method: Composition-based stats.
 Identities = 119/343 (34%), Positives = 179/343 (52%), Gaps = 21/343 (6%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR------EWPVELVVCADATLLTNRAAMLGLPLT 55
           + ++ + IT G+PAGIGP+++V+             + L++      L    A LG  + 
Sbjct: 1   MTSRHLAITMGDPAGIGPEIIVKACLGLKGRIATGDLRLLIIGSGAALDGAKAALGTDVA 60

Query: 56  LRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
           +   S +     +      L   A   P+  G L+ + G +  + + +       G  AA
Sbjct: 61  IPQVSADDR---EWPNLCYLQADAEGDPIKPGVLSADGGRFAYKAIEQGVRLTQAGRTAA 117

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           ++T P++K  +N AG  F GHTE     +  +  VM+LA   +RV+  +TH+ L D+   
Sbjct: 118 IVTAPLNKEALNKAGYHFPGHTEMLAHLTGVRGSVMLLAHGNMRVSHVSTHVALEDVPKR 177

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           +TP  L  VI + +  LR + GIA+P+I V  LNPHAGEGG  G ++ID   P + +  A
Sbjct: 178 LTPERLRMVIDLTNDALR-RLGIAKPKIAVAALNPHAGEGGLFGRQDIDVSAPTIAKAVA 236

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFG-----------RGVNI 284
            G+ + GP+P DT+F        DA +AMYHDQG   +K  GF             GVNI
Sbjct: 237 DGLDVIGPVPGDTIFVKLRAGQFDAAVAMYHDQGHIPVKLLGFQVDPATGRWQELSGVNI 296

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           TLGLP IRTSVDHGTA ++AG+G A+  S I A++ A ++   
Sbjct: 297 TLGLPIIRTSVDHGTAFDIAGKGIANEHSLIEAIDYAERLAAG 339


>UniRef50_Q1GI38 4-hydroxythreonine-4-phosphate dehydrogenase n=30
           Tax=Proteobacteria RepID=PDXA_SILST
          Length = 326

 Score =  390 bits (1003), Expect = e-107,   Method: Composition-based stats.
 Identities = 134/328 (40%), Positives = 180/328 (54%), Gaps = 9/328 (2%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
            Q + ++ GEPAGIGP++ V    +       V   D   L +           +P S  
Sbjct: 5   PQVIALSCGEPAGIGPEIAVAAWDQLRADCPFVWIGDPRHLPS-------SHPWQPVSAP 57

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
           + A   +A  L + P+      T G+   +N   V++++    +   +G+ AAL T P+H
Sbjct: 58  AEALQVSADALPVWPLEFAGNTTKGEADPQNASGVIQSIKTGVELVTSGKAAALCTAPIH 117

Query: 123 KGVIND-AGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           K  + D AG  + GHTEF         VVMMLA+  LRV  AT H+PL  + + +TP  L
Sbjct: 118 KKALIDGAGFAYPGHTEFLAALGGVDHVVMMLASAALRVVPATIHIPLSAVPEVLTPDHL 177

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
             VI +    LR +FG+  PRI V GLNPHAGEGG MG EE D I  ++ E++ +G +L 
Sbjct: 178 RRVITLTDRGLRDQFGLTAPRIAVTGLNPHAGEGGAMGQEEGDWIEALIREMQTEGYRLT 237

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP PADTLF        DA +AMYHDQ L  +K   F +GVN+TLGLPFIRTS DHGTA 
Sbjct: 238 GPHPADTLFHAAARARYDAAIAMYHDQALIPIKTLDFDKGVNVTLGLPFIRTSPDHGTAF 297

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNTQ 329
           ++AG+G A+  S I AL LA  M    Q
Sbjct: 298 DIAGKGLANPSSLIEALRLAQTMAKTRQ 325


>UniRef50_A6H263 4-hydroxythreonine-4-phosphate dehydrogenase n=14 Tax=Bacteroidetes
           RepID=A6H263_FLAPJ
          Length = 349

 Score =  390 bits (1002), Expect = e-107,   Method: Composition-based stats.
 Identities = 104/329 (31%), Positives = 162/329 (49%), Gaps = 6/329 (1%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPY 59
           +   V I+ G+  GIG +++++  +          ++ A+  +L+     L L   L   
Sbjct: 6   ENIIVGISIGDLNGIGSEVILKSFEDSRMLELCTPIIFANVKILSFLKKELRLEAPLHGI 65

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
                        L +        +  GQL    G Y +++   A +    G    L+T 
Sbjct: 66  DRLDQMVIGKINVLNVWREG--VNINYGQLDNAVGKYAIKSFVAATNALKEGGIDVLVTA 123

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P+ K  I      F GHT++ ++  +    +M +  + LRV L T H+PL ++A  +T  
Sbjct: 124 PISKANIQTEDFKFPGHTDYLDQELEG-DALMFMIQDNLRVGLLTDHVPLSEVAKHLTEE 182

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
           L+ + I  ++  L   FGI +P+I V GLNPH+ + G +G EE   I P L ++  +G  
Sbjct: 183 LIRKKIKTINKSLIQDFGIRKPKIAVLGLNPHSSDNGVIGNEEDKIIKPTLKKIFDEGTL 242

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           + GP  AD  F     +N DAV+A YHDQGL   K   FG+GVN T GL  +RTS DHGT
Sbjct: 243 VFGPFSADGFFGNNQYENYDAVIATYHDQGLIPFKTLSFGKGVNYTAGLNKVRTSPDHGT 302

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           A E+AG+G A+  SF+ A+  AI +  + 
Sbjct: 303 AFEIAGKGIANNNSFLEAIYTAIDIFKSR 331


>UniRef50_B5YL57 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Thermodesulfovibrio yellowstonii DSM 11347
           RepID=B5YL57_THEYD
          Length = 316

 Score =  389 bits (1000), Expect = e-107,   Method: Composition-based stats.
 Identities = 112/326 (34%), Positives = 173/326 (53%), Gaps = 15/326 (4%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRP 58
           +  +R+ IT G+PAG+GP+++V+   +E        +V  D  ++     ++G+   L  
Sbjct: 1   MAKKRIAITMGDPAGVGPEIIVKAFAQEDIYKICNPIVIGDKAVIKELIKVIGMDFDLDN 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                         L L  +   + +  G  + E+G      + +A +    G   A++T
Sbjct: 61  IE-----------MLNLNEIKNPSKLLKGTPSEESGRACFSYIRKAVELYRLGVVQAIVT 109

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P+ K  +  AG+P+ GHT+   E +  +   M   +E L+V L T H+PL+++   I  
Sbjct: 110 CPITKVALKMAGLPWLGHTDMLAELTDTEDYAMAFYSEHLKVILVTIHVPLKEVPYLIKK 169

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + + I            I  PRI VCGLNPHAGE G +G EEI+ I P + E +A G+
Sbjct: 170 ENVIKSICFAKKACDM-LRIENPRIAVCGLNPHAGEEGIIGREEIEEITPAIKETKALGI 228

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            ++GP P+D+LF   Y    D V+AMYHDQ L   K   F +GVN T+GLPFIRTS DHG
Sbjct: 229 NVSGPYPSDSLFWRAYKGEFDMVVAMYHDQALAPFKLVAFDKGVNFTVGLPFIRTSPDHG 288

Query: 299 TALELAGRGKADVGSFITALNLAIKM 324
           TA ++A +GKA+  S + A+ LA++M
Sbjct: 289 TAYDIAWQGKAEPTSLLEAIKLAVRM 314


>UniRef50_C1SJH6 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Denitrovibrio
           acetiphilus DSM 12809 RepID=C1SJH6_9BACT
          Length = 322

 Score =  389 bits (999), Expect = e-106,   Method: Composition-based stats.
 Identities = 117/328 (35%), Positives = 175/328 (53%), Gaps = 10/328 (3%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           +K  ++ IT G+P+GIGP++  +LA      E             A  +     ++    
Sbjct: 3   MKKPKIAITTGDPSGIGPEIACRLASELDGSE----------EYDAVFISYENVIKSAFE 52

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           N    P    T+      L   +  G +  E G   +  + +A    ++GE  A++T P+
Sbjct: 53  NIIKAPMPEMTIIEPDEKLDLKIEHGLIKPEYGKASMLYVEKAVQMAMSGEVDAVVTCPI 112

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           +K  I   G  + GHTEF    ++ +   M++  + +R  LATTH+P+ ++ D +    +
Sbjct: 113 NKASIKAGGYNYPGHTEFLGYLTRTRYFSMLMVGKNIRTVLATTHVPMAELVDKLDENSI 172

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
              I   H   +   G  +P+I VCGLNPHAG+ G +G EEI  I PV++  RA GM + 
Sbjct: 173 MNAIVNAHEAGQFFCGKRQPKIAVCGLNPHAGDNGALGDEEITLITPVIDIARAGGMDVE 232

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP PAD+LF        D V+ MYHDQGL  +K + FG  VN+TL LP IRTSVDHGTA 
Sbjct: 233 GPFPADSLFPKAAKGEYDFVVVMYHDQGLIPVKLEAFGNAVNVTLNLPIIRTSVDHGTAF 292

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNTQ 329
           E+AG+G AD  S I A+++A++M+ N Q
Sbjct: 293 EIAGKGIADHHSLIRAIDVAVEMVKNAQ 320


>UniRef50_A7HYG3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Alphaproteobacteria RepID=A7HYG3_PARL1
          Length = 340

 Score =  388 bits (998), Expect = e-106,   Method: Composition-based stats.
 Identities = 141/329 (42%), Positives = 183/329 (55%), Gaps = 5/329 (1%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQ---REWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
             + ++ GEPAGIGP++ ++       +      V  D  L    +  LG    +R  S 
Sbjct: 9   PPLALSMGEPAGIGPEITLKAWAARAEKSLPIFFVAGDPALYRTASERLGAGAAIREISD 68

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            S A     G L +LPV L    T GQL+  N   V+ ++  ACD    G+ + L+T P+
Sbjct: 69  PSEAAEVFPGALPVLPVPLHEAATPGQLSGANAAAVLASIDTACDAVTAGKASGLVTNPI 128

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           HK V+ DAG    GHTE+  ER+   K VMML+   LRV   T HL L+D    +T + +
Sbjct: 129 HKRVLYDAGFHVPGHTEYLAERTGGAKPVMMLSCPGLRVVPVTVHLSLKDAVAVLTTSEI 188

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ--GMK 239
            E   IL   L   FGI++PRI +  LNPHAGE GH+G EEID I P    L     G +
Sbjct: 189 VEHGLILSRSLTADFGISKPRIAIAALNPHAGEEGHLGREEIDIIAPAAKLLAEALPGAE 248

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           ++GPLPADTLF        DAVL MYHDQ L  LK   F RGVNITLGLP +RTS DHGT
Sbjct: 249 ISGPLPADTLFHAAARARHDAVLCMYHDQALIPLKTIDFARGVNITLGLPIVRTSPDHGT 308

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           AL++AGRG AD  S I A+ +A ++  + 
Sbjct: 309 ALDIAGRGVADPESLIEAILVADEITRHR 337


>UniRef50_Q7UMZ2 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Rhodopirellula
           baltica RepID=PDXA_RHOBA
          Length = 351

 Score =  387 bits (995), Expect = e-106,   Method: Composition-based stats.
 Identities = 115/344 (33%), Positives = 164/344 (47%), Gaps = 24/344 (6%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLP------ 53
              ++ IT G+ AGIGP++ +++            ++  DA +    A  LG        
Sbjct: 7   TRPKLAITMGDAAGIGPEISLRVWDSPEVQSQGYPLLFGDAAIYHRAAKKLGCDCPGTIS 66

Query: 54  ----LTLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCL 109
               L +   S  S A          L        T G+ +   G    +++  A D  +
Sbjct: 67  LAEFLDMPKQSIPSDAPHGVIVDCGKLTTEELGSFTPGKFSAATGRASYQSVTDAIDAAV 126

Query: 110 NGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQ------AKKVVMMLATEELRVALA 163
           +G   A++TGP+ K   + AGI F GHTE   +R+          V MMLA++ +   L 
Sbjct: 127 SGHVDAIVTGPIQKEAWHQAGIDFPGHTELLADRAGRAVQGEPADVRMMLASDTIACVLE 186

Query: 164 TTHLPLRDIADAITPALLHEVIAILHHDLRTKF----GIAEPRILVCGLNPHAGEGGHMG 219
           T H+PL D+A  +    L   I +    ++ +      +  PRI VCGLNPHAGE G   
Sbjct: 187 TIHIPLADVASQLNTESLVRTINLAGETVQRRNQNRGSLLPPRIAVCGLNPHAGENGLFS 246

Query: 220 T-EEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGF 278
             EE   I+P +   R  G  + GPL  DT F P   +  D  + MYHDQGL  LK   F
Sbjct: 247 HQEEEQIILPAIEAARQSGWTIEGPLSPDTAFTPAMRERIDIYVCMYHDQGLIPLKALSF 306

Query: 279 GRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAI 322
              VN+TLGLP IRTSVDHGTA++LA +GKA + S + A+  A+
Sbjct: 307 DDAVNVTLGLPIIRTSVDHGTAMDLAWQGKASINSMLAAIRWAV 350


>UniRef50_C6X2C9 4-hydroxythreonine-4-phosphate dehydrogenase n=3
           Tax=Flavobacteriales RepID=C6X2C9_FLAB3
          Length = 363

 Score =  387 bits (994), Expect = e-106,   Method: Composition-based stats.
 Identities = 119/331 (35%), Positives = 179/331 (54%), Gaps = 6/331 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRP 58
               RV I+ G+  GIGP+++++  + +   +    ++     L T +  +  L +    
Sbjct: 5   PHKVRVGISIGDFNGIGPEIIMKTLKDKSITDFFTPIIFGSGKLFTYQKNIFKLQINFNY 64

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
            +    AQ      + L   A    V  G+   E+    +E+L  A D  + G+   L+T
Sbjct: 65  ITEALQAQSDKINMVNL--TADNVNVDLGKPTEESTRMAIESLEAATDALVRGDIDVLVT 122

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P++K  +   G    GHT + EE+ Q KK +M L +E L+VA++T H+P+  +A+ I+ 
Sbjct: 123 APINKDEMIKHGFAHAGHTGYLEEKFQ-KKGLMFLVSEGLKVAVSTHHIPISQVAENISK 181

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + + I IL+  L   F I+ P+I V GLNPHAG+GG +G EEI+ I P + ++   G+
Sbjct: 182 EKIKKQIKILNQCLIEDFQISLPKIAVLGLNPHAGDGGVIGNEEIEIIQPAVKDVFDNGI 241

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
              G  PAD+ FQP      DAVLAMYHDQGL   K   +  GVN T GLP+IRTS DHG
Sbjct: 242 LAFGAFPADSFFQPSKYTKFDAVLAMYHDQGLAPFKTLAYEEGVNYTAGLPYIRTSPDHG 301

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNTQ 329
            A ++AG+  AD  SF  A+ +AIK+  N Q
Sbjct: 302 VAYDIAGQNLADEQSFSEAIFMAIKIFKNRQ 332


>UniRef50_C6P2R8 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Sideroxydans
           lithotrophicus ES-1 RepID=C6P2R8_9PROT
          Length = 358

 Score =  386 bits (993), Expect = e-106,   Method: Composition-based stats.
 Identities = 196/362 (54%), Positives = 241/362 (66%), Gaps = 38/362 (10%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M     +VIT GEPAGIGPDL +QLA  +    LVV AD +LL +RAA+LG  + L  Y+
Sbjct: 1   MTVLAPLVITAGEPAGIGPDLCLQLAGHDQ--PLVVIADKSLLLHRAALLGTGVRLHDYA 58

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            +   +P   G L++L V L  P  AG+L   N  YV+ETL RA  GCL+GEF+ ++T P
Sbjct: 59  AD---RPLENGKLSVLHVPLHRPAQAGKLDSANSPYVLETLRRAVQGCLSGEFSGMVTAP 115

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELR--------------------- 159
           VHKG+INDAGIPFTGHTEF  E++    VVMML    +R                     
Sbjct: 116 VHKGIINDAGIPFTGHTEFLAEQTHTPLVVMMLVGRGMRGRHGDAQHSVREPAQRITDTA 175

Query: 160 ------------VALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCG 207
                       VALATTHLPLR++ADAIT  LL  V+ I+  DL+ +FGIA PRILV G
Sbjct: 176 LAASSENEFVMRVALATTHLPLREVADAITAPLLENVLRIMQRDLQRRFGIARPRILVAG 235

Query: 208 LNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHD 267
           LNPHAGE GH+G EEID +IPVL++LRA+G  ++ PLPADTLF    L + DAVL MYHD
Sbjct: 236 LNPHAGESGHLGREEIDVMIPVLDKLRAEGFNVSPPLPADTLFAAHRLRDCDAVLTMYHD 295

Query: 268 QGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           QGLPVLK+  FG GVNITLGLP IRTSVDHGTALELAG GKA+VGS + A+ +A++M+ N
Sbjct: 296 QGLPVLKHASFGGGVNITLGLPIIRTSVDHGTALELAGTGKAEVGSLLEAIKVAMEMVRN 355

Query: 328 TQ 329
            +
Sbjct: 356 ER 357


>UniRef50_B4S6L0 4-hydroxythreonine-4-phosphate dehydrogenase n=12 Tax=Chlorobiaceae
           RepID=PDXA_PROA2
          Length = 338

 Score =  386 bits (992), Expect = e-106,   Method: Composition-based stats.
 Identities = 114/333 (34%), Positives = 169/333 (50%), Gaps = 10/333 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPV------ELVVCADATLLTNRAAMLGLPLTLRP 58
           +    T G+  GIGP+++++              + +V   A  L   +  LGL + +R 
Sbjct: 2   KTTAWTIGDIHGIGPEIILKTFDESLRSTGQPEEKPIVIGSAEALLYYSKRLGLSIDIRT 61

Query: 59  YSPNSPAQPQTAGTLTLLPVALRA-PVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                 A     G L ++ V   + P+  G ++ E G   +  + +A + CL G  AA++
Sbjct: 62  IDAPEKAAAYPQGVLPVISVGEPSSPLQPGTISAEAGRLSMLAIEKAANLCLEGRCAAMV 121

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATE--ELRVALATTHLPLRDIADA 175
           T P+HK  +  AG P TGHT+F  +        M+       L VALAT H+ L  + + 
Sbjct: 122 TAPIHKEAVARAGYPHTGHTDFLADLCATDNPTMLFRDPVSGLMVALATIHVALHRVPEL 181

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           I    +    + L+  L++ F I +PRI V GLNPHA +GG MG EE + I+P ++ L A
Sbjct: 182 IRSMDMSAFFSNLNRSLQSDFRIEQPRIAVLGLNPHASDGGVMGREEKEIILPCIDAL-A 240

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
               + GP  AD  F      N D  +AMYHDQGL   K   F  G+N+TLGLP +RTS 
Sbjct: 241 DRQNIEGPFAADGFFGSGKYRNYDVTVAMYHDQGLLPFKVLAFDTGINVTLGLPLVRTSP 300

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           DHGT+ ++AG+G+A   SF  A  LA ++  N 
Sbjct: 301 DHGTSFDIAGQGRASHRSFSEAAKLAWEIAFNR 333


>UniRef50_B1L710 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Korarchaeum cryptofilum OPF8 RepID=B1L710_KORCO
          Length = 316

 Score =  386 bits (992), Expect = e-106,   Method: Composition-based stats.
 Identities = 119/318 (37%), Positives = 176/318 (55%), Gaps = 8/318 (2%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           V++T G+P G+GP+++V+   +   + + V      L       GL +   P    +P +
Sbjct: 4   VIVTAGDPLGVGPEVLVKAI-KRLGLPVTVIGSIRSLKKACESCGLDMDFTPVDEPTPLR 62

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVI 126
                 + ++ +       +G    E G +    + +A +  L G+  AL+TGPV K  +
Sbjct: 63  DS----VPVIDIDDFGVEGSG-PTPEGGLHSYLCIRKASELILGGKAEALVTGPVSKEAV 117

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIA 186
           N AGI FTGHTE   E +  +K  MML  +ELRV+  TTH+ L+D+   +T   +   + 
Sbjct: 118 NMAGIKFTGHTELLAELAGGRKTKMMLFLDELRVSHVTTHVALKDVPRLLTEEEIIVTVE 177

Query: 187 ILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPA 246
           +    L  K G    +I V  LNPHAGEGG  G EEI  I P + +L  +G ++ GP+PA
Sbjct: 178 LTSSFL-GKLG-EPGKIGVSSLNPHAGEGGLFGDEEIRIIRPAIEKLIDRGYEVEGPIPA 235

Query: 247 DTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGR 306
           DT+F         AV+AMYHDQG   +K  GF R VN+TLGLP++RTSVDHGTA ++AG+
Sbjct: 236 DTIFLRAMRGEFKAVVAMYHDQGHIPIKLLGFNRAVNVTLGLPYVRTSVDHGTAYDIAGK 295

Query: 307 GKADVGSFITALNLAIKM 324
             AD GS + A+ LA ++
Sbjct: 296 CLADEGSMVNAIRLAFRL 313


>UniRef50_A5CWR9 4-hydroxythreonine-4-phosphate dehydrogenase n=8
           Tax=Gammaproteobacteria RepID=A5CWR9_VESOH
          Length = 332

 Score =  386 bits (992), Expect = e-106,   Method: Composition-based stats.
 Identities = 161/324 (49%), Positives = 204/324 (62%), Gaps = 6/324 (1%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
            +  T GEP+GIGPDL V  AQ +    L++  D  +L NRA  L L + +         
Sbjct: 3   TIAFTVGEPSGIGPDLAVIYAQIKSNKNLLLFTDPDVLLNRAKQLNLNIKI-----IEAE 57

Query: 66  QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
           Q  +   L + P+ +   V  G L  +N  YV+ TL  A + CLN    AL+TGP+HKG+
Sbjct: 58  QAGSNYELAVYPIKVNTHVECGILNKDNAQYVLNTLDCATEYCLNSRCDALVTGPIHKGI 117

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
           IN AGI FTGHTE+    S   K VMMLAT  LRVALATTH+PL D+   IT   L + I
Sbjct: 118 INQAGINFTGHTEYLANLSNIDKTVMMLATNGLRVALATTHMPLSDVPQNITTQSLKKTI 177

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
           +I+H  L    G+  P+I+VCGLNPHAGE G++G EEI+ I P++ EL +QG  L G +P
Sbjct: 178 SIIHQFLLNN-GVNTPKIVVCGLNPHAGENGYLGMEEIEIINPLIKELNSQGYNLVGSIP 236

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
           ADT F P  L   D VL+MYHDQGLPVLK  GF + VNITLGLPFIRTSVDHG+AL LAG
Sbjct: 237 ADTAFTPNSLTGVDCVLSMYHDQGLPVLKTLGFKKAVNITLGLPFIRTSVDHGSALNLAG 296

Query: 306 RGKADVGSFITALNLAIKMIVNTQ 329
            G   +GS  TA+N A  +++N +
Sbjct: 297 TGNISLGSLNTAINYAQMLVINHK 320


>UniRef50_C6XKP9 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Hirschia
           baltica ATCC 49814 RepID=C6XKP9_HIRBI
          Length = 339

 Score =  385 bits (990), Expect = e-105,   Method: Composition-based stats.
 Identities = 123/337 (36%), Positives = 175/337 (51%), Gaps = 10/337 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREW--PVELVVCADATLLTNRAAMLGLPLTLRP 58
           M     + +T G+PAG+GP L  +   +         V A + +L N   + G+   ++ 
Sbjct: 1   MSDNLPLAVTMGDPAGVGPILTWRAWHQRSTTQRPFFVIASSDILKNSQELSGVDGNIQI 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
               + A+     +L +L +        GQ   E+   ++ ++ +A +     + A ++T
Sbjct: 61  IQTPADAEKAFHTSLPVLEIECPDT-KTGQPNPESAAAIIASIEKAVEFTFENKAAGVVT 119

Query: 119 GPVHKGVINDAGIPFTGHTEFFEER-------SQAKKVVMMLATEELRVALATTHLPLRD 171
            P++K ++   G  F GHTEF  E        S+A   +MML    LRVALAT H PLR 
Sbjct: 120 NPINKALLYKKGFKFPGHTEFLAELARQHTHMSKAPLPIMMLVGGGLRVALATIHEPLRK 179

Query: 172 IADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLN 231
           + D +T +L+ EV  I+H  L   FG + P I + GLNPHAGE G +G EEI+ I P   
Sbjct: 180 VPDLLTQSLIEEVSNIVHAGLVRNFGFSSPTIALAGLNPHAGEEGSLGMEEIEQINPAAA 239

Query: 232 ELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFI 291
            LR +G++++   P DT+F        DAV+AMYHDQGL  LK      GVN+TLGLPFI
Sbjct: 240 ALRQRGLQISDAQPGDTVFHAMLEGQFDAVIAMYHDQGLAPLKSLDMWGGVNVTLGLPFI 299

Query: 292 RTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           RTS DHGT   +A  G A   S I A+NLA  M    
Sbjct: 300 RTSPDHGTGYGVAADGSARPDSLIAAINLASDMAKAR 336


>UniRef50_C6XHX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Liberibacter asiaticus str. psy62 RepID=C6XHX7_LIBAP
          Length = 343

 Score =  385 bits (990), Expect = e-105,   Method: Composition-based stats.
 Identities = 109/332 (32%), Positives = 167/332 (50%), Gaps = 9/332 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLR 57
           M +   +++T G+PAGIGPD+ ++             +   D  +L  RA  L L + L 
Sbjct: 1   MDEFLPLILTQGDPAGIGPDISLKAWASRQITAIPPFIYIGDVDVLNARAKQLNLSVPLY 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                + A       L ++     A +  G    +     +  + +A    L+G+  A++
Sbjct: 61  ETDCKN-AVSIFKKALPIISSPCGAKIVTGTPNPQTASSTIANIEKAVSLTLSGQALAIV 119

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAK-----KVVMMLATEELRVALATTHLPLRDI 172
           T P+ K ++      F GHTEF  E ++       K VMML+  +LR    T H+P+ DI
Sbjct: 120 TNPIAKFLLYQEKFKFPGHTEFLAELAKKNTGITFKPVMMLSGPQLRTVPVTIHIPIADI 179

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
              ++   + E    +++ ++  FGI  PRI + GLNPHAGE   +G EE + IIP +  
Sbjct: 180 CRILSTKRIIETSDTVYNAMKKYFGINNPRIAISGLNPHAGENATIGIEEKNIIIPAITY 239

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
           LR     + GPLPAD++F        D  + MYHDQ L  +K   F + VNITLGLPF+R
Sbjct: 240 LRNDNKNIIGPLPADSMFHHSARQCYDVAICMYHDQALIPIKTLDFNQTVNITLGLPFVR 299

Query: 293 TSVDHGTALELAGRGKADVGSFITALNLAIKM 324
           TS DHGTA ++AG       S ++AL +A ++
Sbjct: 300 TSPDHGTAFDIAGSSLTQEESLVSALKIAAQL 331


>UniRef50_Q02C14 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Solibacter usitatus Ellin6076 RepID=Q02C14_SOLUE
          Length = 339

 Score =  385 bits (989), Expect = e-105,   Method: Composition-based stats.
 Identities = 114/317 (35%), Positives = 164/317 (51%), Gaps = 19/317 (5%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPY 59
               + +T G+PAGIGP++V+Q         L   +V  D  +L   + + G+ L  + +
Sbjct: 8   NRPVIALTMGDPAGIGPEIVLQAVADPDLAPLARWIVVGDGEVLEQASRITGIGLQAKLH 67

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
              + A                     G+L    G   VE +  A + CL GE  A++T 
Sbjct: 68  DARALA--------------DIDQFMFGRLDARCGIAAVEYVRIATEMCLAGEAEAIVTA 113

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P++K  +  +G PFTGHTE+  E   A +  M+L +E L     TTH+ LR   +  T A
Sbjct: 114 PLNKEAVTLSGRPFTGHTEYIAELCGATESRMLLCSERLSTIHVTTHVALRTACETGT-A 172

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +   I + +  ++   G +EPRI VCGLNPHAGE G  G E+   I+P +   RA+G+ 
Sbjct: 173 RILRTIELGNDAMK-LLGKSEPRIAVCGLNPHAGEHGLFGDEDQRVIVPAVEAARAKGIA 231

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
            +GP   DT+F        D V+AMYHDQG   +K   F   VNI+LG+P IRTSVDHGT
Sbjct: 232 CSGPHAPDTVFLQAVRGAYDLVVAMYHDQGHIPMKLIDFEGTVNISLGIPIIRTSVDHGT 291

Query: 300 ALELAGRGKADVGSFIT 316
           A ++AG+G+AD  S   
Sbjct: 292 AFDIAGKGRADARSIKQ 308


>UniRef50_Q6AB12 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Actinomycetales RepID=PDXA_PROAC
          Length = 346

 Score =  384 bits (988), Expect = e-105,   Method: Composition-based stats.
 Identities = 109/332 (32%), Positives = 169/332 (50%), Gaps = 8/332 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQL---AQREWPVELVVCADATLLTNRAAMLGLPLTLR 57
           M KT  + IT G+PAGIGP++ VQ       +     +V  D  +++   ++ GL  T+R
Sbjct: 1   MPKTPLLGITEGDPAGIGPEITVQAIHNMADDRSFIPIVYGDPAIISRACSVTGLSETVR 60

Query: 58  PYSPNSPAQPQTAGTLTLLP---VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFA 114
             +     +P++   + ++    V     +  G +    G   + ++  A D  L+G+  
Sbjct: 61  RVTSEEHIEPES-NVINVVDTGTVPHADSIEWGSVQELAGRAAIASIEAATDAALSGKTD 119

Query: 115 ALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIAD 174
            ++T P++K  I   G  F GHTE             M     L++  AT H+ LR+  D
Sbjct: 120 GVVTSPINKEAIWKTGSEFLGHTEMLGSLCGTPDTDTMFVVSGLKIFFATRHMSLREAVD 179

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
           +I   L+   I      L+  FG   P++ V  LNPHAGEGGH GTEEI+ + P +    
Sbjct: 180 SIRRDLIDHEIHKALRALKV-FGCNSPKLAVAALNPHAGEGGHFGTEEIEVLRPAVKSAC 238

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           A+G  + GP+PAD++F    +   D VL++YHDQG    K   F   V++T GLP +RTS
Sbjct: 239 AEGHNVVGPVPADSVFHKGVIREYDGVLSLYHDQGHIASKTLDFDGTVSVTAGLPILRTS 298

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIV 326
           VDHGTA ++AG+G A   +  +AL++A     
Sbjct: 299 VDHGTAFDIAGQGAASPMTMQSALHVASDFAR 330


>UniRef50_Q0FGB3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Rhodobacterales RepID=Q0FGB3_9RHOB
          Length = 325

 Score =  384 bits (988), Expect = e-105,   Method: Composition-based stats.
 Identities = 124/327 (37%), Positives = 167/327 (51%), Gaps = 6/327 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
              V +T G+P GIG D+  +  +  +  +   + AD   L  RA          P    
Sbjct: 2   NLPVALTCGDPNGIGIDISFEAKKELKNRIPFFLIADINHLKKRAHAQSFVKIQHPKECF 61

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
           + ++      L +L        T       N     E + RA D   N E  A+ T P++
Sbjct: 62  NISKD----ILPVLHHEFPETPTLNGSQPGNALATTEVIERAVDLFQNHEIHAICTNPIN 117

Query: 123 KGVINDA-GIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           K V+ +  G  + GHTE+    +  K  VMML  EELRV   T H+ L+D++  +T  LL
Sbjct: 118 KEVLKEGCGFEYPGHTEYLANLAGHKNSVMMLLCEELRVVPTTIHIALKDVSKLLTKELL 177

Query: 182 HEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN 241
              I      L   FGI +PR+ + GLNPHAGE G  G EEI  I P + +LR+QG  + 
Sbjct: 178 INTINTTRDALINHFGIKKPRVAISGLNPHAGENGIFGQEEIKIINPTIEKLRSQGFDII 237

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GPL ADT+F  +  +N D  + MYHDQ L  +K   F  GVN+TLGLPFIRTS DHGTA 
Sbjct: 238 GPLSADTMFHKEARNNYDVAICMYHDQALIPIKTIDFYGGVNVTLGLPFIRTSPDHGTAF 297

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNT 328
           ELAG  KA+  S I+AL +A K+    
Sbjct: 298 ELAGTRKANPRSLISALEVAYKISNGK 324


>UniRef50_A6GTC8 Pyridoxal phosphate biosynthetic protein PdxA n=1 Tax=Limnobacter
           sp. MED105 RepID=A6GTC8_9BURK
          Length = 340

 Score =  384 bits (986), Expect = e-105,   Method: Composition-based stats.
 Identities = 157/334 (47%), Positives = 202/334 (60%), Gaps = 8/334 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLA----QREWPVELVVCADATLLTNRAAMLGLPLTLRP 58
               ++IT GEPAGIGP+L   LA     +     LV+  DA LL  RA   G+    + 
Sbjct: 5   TNLPILITSGEPAGIGPELCALLAETSQAKRLNRSLVILGDADLLETRAKNAGIEPKWQR 64

Query: 59  YSP---NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
            +     +  +P+  G   LL   L  P   GQ    N  YV+  L  ACD C NG  AA
Sbjct: 65  INSLRDIATGEPEAPGYF-LLDHPLSTPCITGQPNPANAPYVLGLLNMACDACQNGTAAA 123

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           ++T P+ K  I+     F GHTE+  ER     VVMML   +++VALATTH+PL  + +A
Sbjct: 124 MVTAPIQKSAISPHWPGFMGHTEYLAERCGQGDVVMMLIGGQMKVALATTHIPLAKVPEA 183

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           IT + L   + I+ HDL   + + +PRILV GLNPHAGE G +G EEIDTI P +  L+A
Sbjct: 184 ITRSSLTRTLEIMLHDLSLYWSLPKPRILVTGLNPHAGESGDLGREEIDTITPTIKALQA 243

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G  + GP PADTLFQPKYL N+DAVLAM+HDQGLPVLK+  FG+GVN++LGLP +RTSV
Sbjct: 244 RGHDVQGPFPADTLFQPKYLQNSDAVLAMFHDQGLPVLKHASFGQGVNVSLGLPIVRTSV 303

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           DHGTAL+LAG    D GS   A+  A  M +  +
Sbjct: 304 DHGTALDLAGTRNMDAGSLNEAIECAHHMDLCRR 337


>UniRef50_UPI0000E87C06 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Methylophilales bacterium HTCC2181
           RepID=UPI0000E87C06
          Length = 324

 Score =  383 bits (984), Expect = e-105,   Method: Composition-based stats.
 Identities = 136/325 (41%), Positives = 192/325 (59%), Gaps = 5/325 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
               +++I  G+P+GIG DL+V LA++ +   + + A+   L  RA + G  L  +    
Sbjct: 3   NDLPKIIINCGDPSGIGLDLIVFLAEKPFNASITILANKESLVQRAGLHGKKLAFQE--- 59

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            + +  +  G L +  +     V  G     N    ++ +  A   C+   + AL+T P+
Sbjct: 60  -NVSLHKGDGRLYVKNIHYENDVIPGLPNKHNSKAQMQMIDHAVKECMAMNYDALVTLPI 118

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKK-VVMMLATEELRVALATTHLPLRDIADAITPAL 180
            K +++D+   FTGHTE+  + S  K   VMML   +LRVALATTH+PL D+   IT   
Sbjct: 119 SKEILSDSNNKFTGHTEYIAKLSNIKNQEVMMLVHNKLRVALATTHIPLSDVPKTITREK 178

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           L ++I  LH+DL+TKF +  PRI V GLNPHAGE G  G EE+  +IP++N+L  QG  L
Sbjct: 179 LEKIILTLHNDLKTKFKVLSPRITVTGLNPHAGENGEFGNEELTVLIPIINKLNEQGCNL 238

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+PADT F P ++   DA LAM+HDQGL   K   FG+GVNITLGLPFIRTSVDHGTA
Sbjct: 239 VGPIPADTAFTPGHIKKTDAFLAMFHDQGLAPFKALSFGKGVNITLGLPFIRTSVDHGTA 298

Query: 301 LELAGRGKADVGSFITALNLAIKMI 325
            ++ G  + D  SF  A+  AI++ 
Sbjct: 299 FDIVGSKEIDPSSFYEAIFTAIELS 323


>UniRef50_Q215S3 4-hydroxythreonine-4-phosphate dehydrogenase n=10
           Tax=Alphaproteobacteria RepID=Q215S3_RHOPB
          Length = 339

 Score =  383 bits (984), Expect = e-105,   Method: Composition-based stats.
 Identities = 126/331 (38%), Positives = 166/331 (50%), Gaps = 8/331 (2%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRP 58
           V  + + +T GEPAGIGPD+ +               +  D   L  RAA LGL +    
Sbjct: 4   VSNKPLALTLGEPAGIGPDVALAAWLGRGTSPIPAFYLLGDRAFLQARAATLGLNVPFAE 63

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                 A    A  L ++          G+    +    +  + +A    + G  AA++T
Sbjct: 64  V-RPDQAAATFADALPVVGTGHPVTAMPGRPDGSSAAAAIGAIRQAVQDVIAGRAAAVVT 122

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAK----KVVMMLATEELRVALATTHLPLRDIAD 174
            P+ K V+  AG    GHTEF  E ++ +    + VMML +E L V   T HLPLRD   
Sbjct: 123 NPIAKSVLYQAGFKHPGHTEFLAELARGEGAPPQPVMMLWSEALAVVPVTIHLPLRDAIA 182

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +T  L+     I+   LR    IA PR+ V GLNPHAGE G +G E+   I P +  LR
Sbjct: 183 QLTTGLIVSTARIVASALRRHMRIAAPRLAVSGLNPHAGEDGGLGREDQSIIAPAVEILR 242

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
             G+   GPLPADT+F        D  L MYHDQ L  +K   F R VN+TLGLPF+RTS
Sbjct: 243 RDGIDARGPLPADTMFHEAARKTYDCALCMYHDQALIPVKTLAFDRAVNVTLGLPFVRTS 302

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMI 325
            DHGTA ++AG G+AD  S I AL LA +M 
Sbjct: 303 PDHGTAFDIAGSGRADPSSLIEALRLAARMA 333


>UniRef50_D0LQB4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Haliangium
           ochraceum DSM 14365 RepID=D0LQB4_HALO1
          Length = 338

 Score =  383 bits (984), Expect = e-105,   Method: Composition-based stats.
 Identities = 119/334 (35%), Positives = 164/334 (49%), Gaps = 19/334 (5%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPV---ELVVCADATLLTNR-AAMLGLPLTL 56
           M  + ++ IT G+PAGIGP+++              L +  D  +L    A + G  +  
Sbjct: 1   MTTSDKIGITLGDPAGIGPEIIAAAVADASAELRGRLTLFGDRPILERAFAQITGSRI-- 58

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
                 S  Q    G L+            G     +G   V  L  A      G    L
Sbjct: 59  -----PSDIQVVDRGLLS------ADQAIPGSPTGASGAAQVAYLEAAVSAARRGTIGGL 107

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
           +T P++K     AG  F GHTEF  ER  A+ V MM A   L+V LAT HL L ++  A+
Sbjct: 108 VTAPINKRSARQAGFSFPGHTEFLAERLGAQHVAMMFAGPRLKVVLATVHLALSEVPGAL 167

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           T   +     +    +   FGIA  R+ V GLNPHAGE G  G EE++ I P + E R Q
Sbjct: 168 TRDGIVRTAKLAAEAVSRDFGIASARVGVLGLNPHAGEHGLFGREELEIIGPAIEECRRQ 227

Query: 237 --GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
             G +++GPL  D  F+       D ++AMYHDQGL  +K   F + VN+TLGLP +RTS
Sbjct: 228 IDGAQVDGPLIPDAAFRQADGGAYDVLVAMYHDQGLIPVKLLDFEQAVNVTLGLPIVRTS 287

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
            DHG A ++AG GKA   SF+ AL+LA ++  + 
Sbjct: 288 PDHGVAYDIAGTGKARPQSFMAALSLAARLTTHR 321


>UniRef50_A0LA33 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Magnetococcus
           sp. MC-1 RepID=A0LA33_MAGSM
          Length = 346

 Score =  380 bits (978), Expect = e-104,   Method: Composition-based stats.
 Identities = 120/340 (35%), Positives = 180/340 (52%), Gaps = 13/340 (3%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWP--------VELVVCADATLLTNRAAMLGL- 52
           +    + +T G+PAGIGP++V++   ++           + +   D  +L   A  +GL 
Sbjct: 1   MDALPIALTMGDPAGIGPEIVLKAFAQQQRERQKRLAGAKWLWVGDPEVLLWTAQQMGLV 60

Query: 53  PLTLRPYSPNSPAQPQTAGTLTLLPVA---LRAPVTAGQLAVENGHYVVETLARACDGCL 109
           P  L+     +         L +LP+     R  +  G     +   VVE++  A    +
Sbjct: 61  PPKLQRVRQAAEVAQVADEVLAVLPLEACIDRHKLAFGVADGAHAKAVVESIETATALAM 120

Query: 110 NGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPL 169
           +G+   ++T P+HKGV++  G  + GHTE     +     VMMLA   LRV  AT H  +
Sbjct: 121 SGQVGGVVTPPIHKGVLHAGGYRWPGHTELLGHCTGVTTPVMMLAGRGLRVVPATIHQSI 180

Query: 170 RDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPV 229
           R + D+++ A L ++ +++ H L+  FG+ EPRI +C LNPHAGEGG  G EE   I P 
Sbjct: 181 RSVPDSLSVAKLTQIFSVVGHSLQQDFGLREPRIAICALNPHAGEGGAFGDEERRIIQPA 240

Query: 230 LNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLP 289
           +  L  + ++L GP PAD LF         A++ MYHDQ L  +K   FG   NITLGLP
Sbjct: 241 MAALMGE-VRLEGPFPADALFSEAARAPYGAIICMYHDQALIPIKMHCFGEATNITLGLP 299

Query: 290 FIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
            IRTSVDHGTA ++AG G+A  G+ + A+  A +M  N +
Sbjct: 300 IIRTSVDHGTAYDIAGSGRAKHGALLIAVEQAARMAANRR 339


>UniRef50_C0CYU8 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CYU8_9CLOT
          Length = 331

 Score =  380 bits (978), Expect = e-104,   Method: Composition-based stats.
 Identities = 104/325 (32%), Positives = 167/325 (51%), Gaps = 7/325 (2%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
              ++I  G+PAGIGP++  +   RE        VV  D  ++     ++ LPLT+   +
Sbjct: 2   KPIILIPMGDPAGIGPEIAAKALAREETLQRARCVVVGDRQVMEQAVRIVDLPLTIHTIN 61

Query: 61  PNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                + +    + L+ +A         G+++   G    E +A +      G+ AA+ T
Sbjct: 62  EPEEGRFEE-RVINLIDLANVDMGQFKRGEISAMCGRAAYEYIATSISLANAGKAAAVST 120

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P++K  +  AG+P+ GHTE F   +     + M     +RV   T H+ LR   D IT 
Sbjct: 121 TPINKESLRAAGVPYIGHTEIFGALTGTPDPLTMFEVRNMRVFFLTRHVSLRKACDMITK 180

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             + + +      L+   G+ +  + + GLNPH+GE G  G EE++ I P + EL+AQG 
Sbjct: 181 ERVIDYVKRCTQALKQ-LGVEDGTMAIAGLNPHSGEHGLFGDEEMEAIYPAVEELQAQGY 239

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           K+ GP+ AD++F        ++VL++YHDQG    K   F R + +T G+P +RTSVDHG
Sbjct: 240 KVAGPVGADSVFHMALQGKFNSVLSLYHDQGHIATKTLDFERTIAVTAGMPILRTSVDHG 299

Query: 299 TALELAGRGKADVGSFITALNLAIK 323
           TA+++AG G A   S + A+ LA K
Sbjct: 300 TAMDIAGTGIASDVSMVEAIRLAAK 324


>UniRef50_B1IGV8 4-hydroxythreonine-4-phosphate dehydrogenase n=39 Tax=Bacteria
           RepID=PDXA_CLOBK
          Length = 334

 Score =  380 bits (977), Expect = e-104,   Method: Composition-based stats.
 Identities = 93/328 (28%), Positives = 160/328 (48%), Gaps = 7/328 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREW---PVELVVCADATLLTNRAAMLGLPLTLR 57
           +     + I  G+PAG+GP++VV+             ++  DA ++        + L + 
Sbjct: 2   INNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNIN 61

Query: 58  PYSPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
                   +    GT+ L+ +       +  G++    G    E + ++ +    GE  A
Sbjct: 62  SIKKADEGKFT-LGTIDLIDLNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELDA 120

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           + T P++K  + +  + + GHTE   + +  +  + M     +RV   T H+ LR   D 
Sbjct: 121 IATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEVRGMRVFFLTRHVSLRKACDL 180

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           +T   + + I      L  K G+ + ++ V GLNPH+GE G  G EE+  ++P + E + 
Sbjct: 181 VTKERVLDYIIRCSEAL-EKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQK 239

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
            G K+ GP+ AD++F        ++VL++YHDQG    K   F R + +T G+P +RTSV
Sbjct: 240 MGYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTSV 299

Query: 296 DHGTALELAGRGKADVGSFITALNLAIK 323
           DHGTA ++AG G+A   S + A+ LA K
Sbjct: 300 DHGTAFDIAGTGQASSVSMVEAIVLAAK 327


>UniRef50_Q2N8X0 4-hydroxythreonine-4-phosphate dehydrogenase n=5
           Tax=Sphingomonadales RepID=PDXA_ERYLH
          Length = 336

 Score =  377 bits (970), Expect = e-103,   Method: Composition-based stats.
 Identities = 114/329 (34%), Positives = 161/329 (48%), Gaps = 6/329 (1%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQ---REWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           + + ++ G+PAGIGP+++V   +           V   A +L +    LG+P  ++    
Sbjct: 6   RPLAVSLGDPAGIGPEIIVHAWRMRDSANLAPFAVAGGANVLRSATEALGVPCPIQEIDD 65

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            + A       L ++   L      G          +++L  A      G  + ++T P+
Sbjct: 66  IAEANSAFLEALPVI-KGLDGAYLPGAPDPIGAKLALKSLEMATRLATAGHASGVVTAPI 124

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKK--VVMMLATEELRVALATTHLPLRDIADAITPA 179
            KG++   G    G TEF        +   VMMLA   LR    T H PL ++   ++  
Sbjct: 125 AKGLLEQVGFTHPGQTEFLAAACGLPEDASVMMLAGPSLRAVPLTVHCPLAEVPGLLSIG 184

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
           L+ E   I+   L+  FGI  PR+ V GLNPHAGE G  G EE D I P + EL A G+ 
Sbjct: 185 LIVERGRIVASALQRDFGIERPRLAVTGLNPHAGEDGKFGNEEQDVIAPAIAELLADGIT 244

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
             GP PAD LF P      DA L MYHDQ L  +K   F +GVN+TLGLP +RTS DHGT
Sbjct: 245 ATGPHPADALFSPHSRAGFDAALCMYHDQALIPVKALDFDQGVNVTLGLPIVRTSPDHGT 304

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           A ++AGRG A  G+ + AL +A +     
Sbjct: 305 AFDIAGRGTAHPGAMVFALLMAGECAARR 333


>UniRef50_C6C747 4-hydroxythreonine-4-phosphate dehydrogenase n=17 Tax=Bacteria
           RepID=C6C747_DICDC
          Length = 341

 Score =  377 bits (970), Expect = e-103,   Method: Composition-based stats.
 Identities = 100/326 (30%), Positives = 159/326 (48%), Gaps = 7/326 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRPY 59
               V +T G+PAGIGP++ V     +         +     ++    A+      +   
Sbjct: 11  NKPVVALTIGDPAGIGPEISVATMMNQAVYEECRPFLIGSVPIIQRAMAIWNCDFAINVI 70

Query: 60  SPNSPAQPQTAGTLTLLPVAL--RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
              + A+    GTL +L         +  G++    G   ++ + ++    + GE   + 
Sbjct: 71  HSPAEARFTW-GTLDVLETGDYDCDSIVWGKVQKLAGQMSLDYVMKSIALGMAGEIDVVS 129

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           T P+HK  I  AG    GHTE ++  + +   + M   ++LRV   + H+ L+D  D   
Sbjct: 130 TAPIHKEAIKLAGCKLPGHTEIYQVETGSDYGLTMFHVQKLRVFFVSRHMALKDACDYAN 189

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              +   +  +HH+      I +PRI V  LNPHA + G  G EE D +IP +   +A G
Sbjct: 190 KERVLACVQQIHHEFTA-LNIPQPRIAVAALNPHASDNGLFGHEEKDNLIPAVQAAQALG 248

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           +   GP+PAD++F    L + DA+L++YHDQG    K   F R V IT GLPF+R+SVDH
Sbjct: 249 INAIGPVPADSVFHQGKLGHYDAILSLYHDQGHIACKTLDFERSVTITFGLPFMRSSVDH 308

Query: 298 GTALELAGRGKADVGSFITALNLAIK 323
           GTA ++AG GKA   S + +  +A +
Sbjct: 309 GTAFDIAGTGKAGTVSMLESTLVAAR 334


>UniRef50_A6C4H6 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Planctomyces
           maris DSM 8797 RepID=A6C4H6_9PLAN
          Length = 344

 Score =  376 bits (967), Expect = e-103,   Method: Composition-based stats.
 Identities = 111/342 (32%), Positives = 156/342 (45%), Gaps = 16/342 (4%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +K   + +T G+ +GIGP L+  L            VV  +A +L   +   G  L +R 
Sbjct: 1   MKLPLIALTMGDVSGIGPQLLDVLCSGSEIFQICRPVVYGNAAVLRRASQQSGSQLQIRE 60

Query: 59  YSPNSPAQPQTAGTLTLLPVALR--APVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
               S +     G    +       A V   Q+   +G    + L  A D CL+GE  A+
Sbjct: 61  IESISDSLEFRVGIANCIDRGNSNVAEVVPCQIDARSGQGAYDYLVSAIDDCLSGEMDAI 120

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATE---------ELRVALATTHL 167
            T P++K  +  AGI + GHTE   +R       MML             L +   T H 
Sbjct: 121 TTAPLNKESLRLAGIDYPGHTEILADRCGVADYGMMLYLPHGAAIQSPAGLGIVHTTLHT 180

Query: 168 PLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTII 227
            +  +   ++   + E I ++   L  K G+A PR+ VC LNPHAGE G  G EE   I 
Sbjct: 181 SIASVPGLLSTDAIFEKIRLI-SGLMQKMGVAHPRVAVCALNPHAGEHGLFGDEEARIIS 239

Query: 228 PVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLG 287
           P + +    G+   GPLPADTL +       DAV+AMYHDQG    K  GF + VNITLG
Sbjct: 240 PAVEQAIQSGLDATGPLPADTLIRRAVRGEFDAVVAMYHDQGHIPFKLLGFDQAVNITLG 299

Query: 288 LPFIRTSVDHGTALELAGRGKA-DVGSFITALNLAIKMIVNT 328
           LP +RTS  HGTA ++A      +    I A   A ++  + 
Sbjct: 300 LPIVRTSPSHGTAFDIAWSDTVPETRGIIEATKAAARLSQHQ 341


>UniRef50_P58711 4-hydroxythreonine-4-phosphate dehydrogenase n=64 Tax=root
           RepID=PDXA_ANASP
          Length = 362

 Score =  375 bits (963), Expect = e-102,   Method: Composition-based stats.
 Identities = 113/345 (32%), Positives = 170/345 (49%), Gaps = 24/345 (6%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPYS 60
             R+ +T G+P GIG +++++           +L V ++  LL      L     L P +
Sbjct: 17  RPRLALTVGDPGGIGAEVILKALADLEIGHNYDLTVVSNKNLLQETYKQLSSMENLLPLA 76

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
             +  +         +       +  G     +G      +  A    L G F  ++TGP
Sbjct: 77  DPNLLKIIDVT----VDRETARQINLGTGNAASGAASFAYMDYAIAQTLAGNFDGIVTGP 132

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLA------TEELRVALATTHLPLRDIAD 174
           + K     AG  + G TE   ++S  ++  M+           LR  LATTH+PLR +AD
Sbjct: 133 IAKSAWKAAGYNYPGQTELLAQKSGVERFGMLFVARSPYTGWTLRALLATTHIPLRQVAD 192

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            +TP LL + + +L   L   FGI   RI + GLNPH+GE G +GTEE+D +IP L   R
Sbjct: 193 TLTPQLLTQKLDLLVECLEKDFGITSGRIAIAGLNPHSGEQGQLGTEELDWLIPWLESER 252

Query: 235 AQ--GMKLNGPLPADTLFQPKYLDNA---------DAVLAMYHDQGLPVLKYQGFGRGVN 283
            +    +L+GP+P DT++                 DA LA+YHDQGL  +K   F R VN
Sbjct: 253 QKRPHFQLDGPIPPDTMWVKPGQAWYGNAIVQHPADAYLALYHDQGLIPVKLMAFDRAVN 312

Query: 284 ITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
            ++GLPF+RTS DHGTA ++AG+G AD  S   A++LA +++   
Sbjct: 313 TSIGLPFVRTSPDHGTAFDIAGQGIADATSMKEAISLAAELVCQR 357


>UniRef50_Q8D3I2 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Gammaproteobacteria RepID=PDXA_WIGBR
          Length = 332

 Score =  373 bits (959), Expect = e-102,   Method: Composition-based stats.
 Identities = 168/326 (51%), Positives = 222/326 (68%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M K  R++ITPGEPAGIG DLVV ++Q+ W  ELV+C D  +L  RA   G+ L L  Y+
Sbjct: 1   MNKISRIIITPGEPAGIGFDLVVLISQKIWRSELVICCDPDILVKRAKDHGIKLKLHFYN 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            N   + +  G LT++P+ + + VT G L + N +YV+ TL RAC GC+N EF+AL+TGP
Sbjct: 61  KNLSPKVREKGELTIIPIKVNSNVTRGILNINNSYYVINTLTRACLGCINKEFSALVTGP 120

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           VHKG+I D+GI F GHTEF    S  K  VMML    LR+ALAT H+P++DI+  I   L
Sbjct: 121 VHKGIIKDSGIKFIGHTEFLAGFSLCKNPVMMLMYNSLRIALATNHIPIKDISKCINFNL 180

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           + + + ++ + LR  F I  P I VCGLNPHAGE GH+GTEEI+ I P ++ L+    K+
Sbjct: 181 IRKKLIVIFNSLRNIFKINNPCIYVCGLNPHAGESGHIGTEEINIIQPAISSLKYLPCKI 240

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+ AD++FQ KYL +ADA+LAMYHDQGLP++KY GF + VNITLGLPFIRTSVDHGTA
Sbjct: 241 IGPISADSIFQQKYLKDADAILAMYHDQGLPMIKYIGFRKSVNITLGLPFIRTSVDHGTA 300

Query: 301 LELAGRGKADVGSFITALNLAIKMIV 326
           L +    +    S   A++LAI +  
Sbjct: 301 LNIKNLNEISSKSMEKAISLAIDISQ 326


>UniRef50_Q5NMX3 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Zymomonas
           mobilis RepID=PDXA_ZYMMO
          Length = 335

 Score =  372 bits (955), Expect = e-101,   Method: Composition-based stats.
 Identities = 114/330 (34%), Positives = 165/330 (50%), Gaps = 10/330 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQ---REWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           + + +T G+P+GIGP++V +       +  +       A  +   +++      +   + 
Sbjct: 2   KPLAVTLGDPSGIGPEIVAKAWSRRKSDQIMPFFAIGSAASIQAVSSI-----PVVAITD 56

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            + A       L +  +  +  +T G+            L +       G+ +AL+T PV
Sbjct: 57  PNEAISIFDQALPVWDIPSKETITPGKPNKAGAEVAFAALEKGVALVKQGQASALVTAPV 116

Query: 122 HKGVINDAGIPFTGHTEFFEERSQ--AKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
            K  +   G  F G TEF   R    A   VMMLA  +LR    T H+P RD+ + +TP 
Sbjct: 117 SKAELYQVGFTFPGQTEFVANRCGIAADDAVMMLAGPDLRTVPLTIHIPYRDVLEQLTPK 176

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
           L+     +   DL+  F I  PR++V GLNPHAGE G +G EEID+I P + +L+A+ + 
Sbjct: 177 LIISRARVTVEDLKRNFAIPSPRLVVAGLNPHAGENGTIGREEIDSIEPAIRQLQAENID 236

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           + GP  ADTLF P+     D  L   HDQ L  +K   F  GVN TLGLP IRTS DHGT
Sbjct: 237 IKGPFAADTLFSPRARATYDVALCPTHDQALIPIKTINFDNGVNTTLGLPIIRTSPDHGT 296

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           A  LAG+ KAD G+ + AL +A     N Q
Sbjct: 297 AFPLAGKNKADEGAMVAALVMAANSAHNRQ 326


>UniRef50_D0J9Z1 4-hydroxythreonin-phosphate dehydrogenase n=1 Tax=Blattabacterium
           sp. (Periplaneta americana) str. BPLAN
           RepID=D0J9Z1_BLASP
          Length = 363

 Score =  371 bits (954), Expect = e-101,   Method: Composition-based stats.
 Identities = 106/338 (31%), Positives = 175/338 (51%), Gaps = 12/338 (3%)

Query: 1   MV----KTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLP 53
           M+    K  +V ++ G+  GIG ++ +++ +++  ++    ++     L +    +L + 
Sbjct: 21  MMNYRKKKIKVGVSTGDINGIGIEIFLKVCRKKKLLDFFTPILFGSIKLCSYYKKILNIE 80

Query: 54  LT-LRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGE 112
           +  +R               L +    ++  +   ++  ++G Y + +L +A      G+
Sbjct: 81  VNNMREIKNLKDIVDYKINVLNIWKEDIKFDLI--KINQDSGKYPILSLKKATKALKEGK 138

Query: 113 FAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDI 172
              L+T PV+K  +N     F GHTE+ +   +  + +M++  + L++AL T HLPL+++
Sbjct: 139 IDVLVTAPVNKNWMNHKEFSFFGHTEYLQNILEG-ESLMLMIHDTLKIALVTNHLPLKNV 197

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
              IT   + + I ILH  L   F I +P+I V G NPH+GE G +G EE   I P ++ 
Sbjct: 198 THEITTKKIIKSIKILHKSLIMDFSIEKPKIAVLGCNPHSGENGLIGDEEKTKIKPAIDS 257

Query: 233 L-RAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFI 291
           L + QG  + GP   D  F  ++  N DAVLAMYHDQGL   K   F  GVN T GL  I
Sbjct: 258 LFQKQGFLVFGPYSPDGFFGNQHYRNFDAVLAMYHDQGLIPFKTLTFNEGVNFTAGLSHI 317

Query: 292 RTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           RTS DHG A ++A +G A+  SF  A+  AIK+  N +
Sbjct: 318 RTSPDHGVAYDIAKKGIANENSFEEAIFSAIKIFKNRK 355


>UniRef50_A8S524 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8S524_9CLOT
          Length = 334

 Score =  371 bits (954), Expect = e-101,   Method: Composition-based stats.
 Identities = 90/320 (28%), Positives = 145/320 (45%), Gaps = 5/320 (1%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLR 57
           M     + I  G+ AG+GP+++V+LA           VV  D  +    A + GL + ++
Sbjct: 1   MSGKPILGILLGDAAGVGPEIIVKLAASRFYDEYCRPVVIGDVRVFERGARICGLEIPVQ 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                  A       +          V    +++E+G   +  L  A +    G      
Sbjct: 61  VIDKVEEADWTKGMPVLDQRDVDPEQVPFANISIESGRACLNMLKTAIELYQAGRIDGFC 120

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAI 176
             P++K  +  AG PF     +        +    +    +L     T+H+P+  ++D++
Sbjct: 121 FAPLNKQAMIQAGCPFESEHHYMAHLFGHTEPFGEINVLGDLWTTRTTSHIPISKVSDSL 180

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           T   +   I + +  L+   GI +PR+ +  LNPH GEGG  G EEID I P + + R  
Sbjct: 181 TVDTIMRAIRLANVSLKNS-GIEKPRLALAALNPHCGEGGKCGREEIDVIAPAIEKAREM 239

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G+  NGP P+D LF   +  + D V+ MYHDQG   LK +GF +G+ I  GLP    +  
Sbjct: 240 GIDANGPFPSDILFIKAFNGDFDGVVTMYHDQGQIALKLKGFDQGITIAGGLPAPIVTCA 299

Query: 297 HGTALELAGRGKADVGSFIT 316
           HGTA ++AG+G     +F  
Sbjct: 300 HGTAYDIAGKGIVKTSAFEN 319


>UniRef50_D2R6V9 4-hydroxythreonine-4-phosphate dehydrogenase n=7 Tax=Bacteria
           RepID=D2R6V9_9PLAN
          Length = 344

 Score =  370 bits (951), Expect = e-101,   Method: Composition-based stats.
 Identities = 120/333 (36%), Positives = 179/333 (53%), Gaps = 8/333 (2%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRP 58
           + ++RV IT G+ AG+GP++ ++L            +V  DA +LT  +A  G+      
Sbjct: 12  MPSKRVAITMGDAAGVGPEICLRLLADPQIVRECIPIVIGDAEVLTRVSAATGISWQADV 71

Query: 59  YSPNSPAQPQTAG---TLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
            S     +  +A    T+  LP    A V  G ++   G    E ++ A D  +  +  A
Sbjct: 72  ISLGEWNRAPSAIVRPTVVHLPSLDAASVVPGSISAMTGRASYEYISAAIDAVIAQDVCA 131

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA 175
           + TGP+ K  ++ AG+ F GHTE F  R+ +++  MM  +E +     T H+   ++ + 
Sbjct: 132 VTTGPISKEALHAAGLKFPGHTEIFASRTSSQRSCMMQYSEIITCTFVTVHVGYYEVPEL 191

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMG-TEEIDTIIPVLNELR 234
           +T   + +VI +    L    G A P+++VCGLNPHAGE G  G  EE   IIP +   R
Sbjct: 192 LTTERIGDVIDLTADALLKIRGRA-PKMVVCGLNPHAGEHGLFGNREEERVIIPAIAAAR 250

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           A+G +++GPLP DT F P      DA + MYHDQG   +K   F + VN TLGLP IRTS
Sbjct: 251 ARGHQIDGPLPPDTCFTPAKRAITDAFICMYHDQGHIPVKALAFEQAVNTTLGLPVIRTS 310

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           VDHGTA ++A +GKAD  S   A+ LA+++  N
Sbjct: 311 VDHGTACDIAWQGKADPSSLFAAVRLAVRLADN 343


>UniRef50_A0NP49 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Rhodobacteraceae RepID=A0NP49_9RHOB
          Length = 340

 Score =  369 bits (949), Expect = e-101,   Method: Composition-based stats.
 Identities = 107/335 (31%), Positives = 170/335 (50%), Gaps = 7/335 (2%)

Query: 1   MVK-TQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTL 56
           M     R+V+T G+PAGIG +LV +L           +++  D   L N   + G+    
Sbjct: 1   MTTPKPRLVLTLGDPAGIGSELVARLLADEEARQAAAILILGDEDELKNGMDIAGVRFEY 60

Query: 57  RPYSPNS-PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
              S  + P+Q     +   +  A        +++ E G + +ETL +  D   +G+  A
Sbjct: 61  EKVSEAALPSQATDVPSFFQVGTAPEGGWKRAEVSAEGGAHCLETLGKGVDLVRSGKADA 120

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAK-KVVMMLATEELRVALATTHLPLRDIAD 174
           L+  P++K  ++ AG+  +    +F +R      V  +   + L  +  T+H+ LRD+AD
Sbjct: 121 LVFAPLNKASLHSAGMSQSDELHWFADRLGHNGSVSELNVMDGLWTSRVTSHIALRDVAD 180

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            IT   + E   ++H  L+   G   PRI VCGLNPH G+ G+ GTEEI+ I P +   +
Sbjct: 181 LITEDKIIEAARLIHSALK-DAGFESPRIGVCGLNPHNGDNGNFGTEEIEIITPAVERAK 239

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           A G+ + GP P+DT+F        DA++ +YHDQG   +K  GF +GV +  GLP   T+
Sbjct: 240 ALGLPVEGPYPSDTIFLKAVAKELDAIVTLYHDQGQIAIKLLGFWQGVTVQGGLPIPITT 299

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
             HGTA ++ G+G A+VG    A N+A  M    +
Sbjct: 300 PAHGTAFDIRGKGTANVGPMRNAWNIACAMGTRRR 334


>UniRef50_Q92X16 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=18
           Tax=Alphaproteobacteria RepID=PDXA2_RHIME
          Length = 321

 Score =  369 bits (948), Expect = e-101,   Method: Composition-based stats.
 Identities = 102/328 (31%), Positives = 161/328 (49%), Gaps = 18/328 (5%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPYS 60
           ++ + IT G+P G+GP++ V+        +     +  +   L      LGL + L+PY 
Sbjct: 2   SKIIGITMGDPCGVGPEITVRSLAEMSAADREATRIYGNLATLEAAREALGLSVDLQPYV 61

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            +   +               AP+  G L+   G      + RA      G    ++T P
Sbjct: 62  VDLTVE--------------GAPLPWGSLSAVAGDAAFRFIERAVRDAEAGNIGCIVTAP 107

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           ++K  +N AG  + GHT      + +    M+LA+E L+V   +TH+ L++     T   
Sbjct: 108 INKEALNMAGHHYDGHTGMLRSLTGSSAAYMLLASERLKVIHVSTHVSLKEAIGRATTER 167

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +   I   +  L+ + G   PRI V G+NPH GE G  GTE+ D I P +   R +G+ +
Sbjct: 168 VLATIRAGNAHLK-RIGYEHPRIAVAGINPHCGENGLFGTEDDDQIGPAVAAAREEGIDV 226

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+ ADT+F   Y    D V+A YHDQG   +K   F   VN+++ LP  RTSVDHGTA
Sbjct: 227 QGPISADTVFHRAYSGGFDLVVAQYHDQGHIPIKLVAFDTAVNVSVDLPIDRTSVDHGTA 286

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNT 328
            ++AG+G A+ G+  +A+  A K++   
Sbjct: 287 FDIAGKGIANHGNLNSAIAYARKLVAGQ 314


>UniRef50_Q0EWH4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Mariprofundus
           ferrooxydans PV-1 RepID=Q0EWH4_9PROT
          Length = 340

 Score =  368 bits (946), Expect = e-100,   Method: Composition-based stats.
 Identities = 130/338 (38%), Positives = 183/338 (54%), Gaps = 14/338 (4%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           + ++IT GEPAGIG D +++  Q   +   + ++ A A  L  RA ++G+ + ++  +  
Sbjct: 2   KPLLITAGEPAGIGTDCILRAWQHTPQLFKQCIIAAPALWLRERADLIGIDVIIKESADL 61

Query: 63  SPAQPQTAGTLTLLPVALR----APVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                     L             PVT GQ +      V+  +  A   CL+   AALIT
Sbjct: 62  QQIDCSDTSRLHCWNPLAANVAVDPVTPGQPSPGTARAVITCIESAALACLDNRAAALIT 121

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAK--------KVVMMLATEELRVALATTHLPLR 170
           GP+ K V+ ++G  F GHTEF    S++           VMMLA+++LRVAL TTH+ + 
Sbjct: 122 GPIEKAVLRESGFTFPGHTEFLAHLSRSNASLATDHMDHVMMLASDQLRVALLTTHIAIS 181

Query: 171 DIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVL 230
           D+  +++     + + I+ HDLR +F I +P I +CGLNPHAGE GH G EEID + P  
Sbjct: 182 DVPASLSIDGTLDGLRIVEHDLRKRFAIEKPHIGLCGLNPHAGEQGHFGREEIDILTPAA 241

Query: 231 NELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPF 290
              + +G+ + GPLPADTLF        DA++  YHDQ L  LK   FG  VNITLGLPF
Sbjct: 242 ELAKKRGIHVTGPLPADTLFSASQRSRFDAIVCCYHDQALIPLKALSFGDAVNITLGLPF 301

Query: 291 IRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           IRTSVDHGTAL+  G       S + A+ +A  M    
Sbjct: 302 IRTSVDHGTALDRVGSQSVSYTSMVAAIRMASTMTTAK 339


>UniRef50_Q4JN67 Predicted 4-hydroxythreonine-4-phosphate dehydrogenase
           (4-(Phosphohydroxy)-L-threonine dehydrogenase) n=1
           Tax=uncultured bacterium BAC13K9BAC RepID=Q4JN67_9BACT
          Length = 326

 Score =  367 bits (943), Expect = e-100,   Method: Composition-based stats.
 Identities = 128/324 (39%), Positives = 191/324 (58%), Gaps = 1/324 (0%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + ++ IT G+P GIGPD+ V +A++      ++  D  LL + +  L   + +      +
Sbjct: 2   SIKIAITVGDPGGIGPDICVLMAEKYLKKYHIIITDPQLLIDSSKKLNKKVFINILKNIN 61

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A       + +LP+ L      G +   N  +V+  +  A  GCLN  F +++TGP+ K
Sbjct: 62  DAPKSGKRLINVLPIKLNKKNKPGHMNPINAPFVINAIETAAKGCLNHNFQSMVTGPISK 121

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
            ++N  G   +GHTE   +  ++K  +MML  ++L+V L T H+PL  ++  IT   +  
Sbjct: 122 SILNRGGFKISGHTELLAKICKSK-SIMMLMNDKLKVTLQTIHVPLNKVSKQITEKNIIG 180

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            I I++HDL  KFG+  P+IL+CGLNPHAGE G +G EEI+ I P +  L+  G+ ++GP
Sbjct: 181 KIKIINHDLINKFGLKNPKILICGLNPHAGEEGILGNEEINIIKPAILSLKKLGINVDGP 240

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           +PADT F  KY++  D +  MYHDQGLPV+KY  F +  N+TLGLP IR SVDHGTA EL
Sbjct: 241 VPADTAFISKYINEYDVIHTMYHDQGLPVIKYDNFSKTTNVTLGLPIIRVSVDHGTATEL 300

Query: 304 AGRGKADVGSFITALNLAIKMIVN 327
            G G  D+ SFI AL +A  +  +
Sbjct: 301 VGTGNVDISSFIQALKVARDISKS 324


>UniRef50_Q30Z16 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Desulfovibrionales RepID=Q30Z16_DESDG
          Length = 365

 Score =  365 bits (939), Expect = e-99,   Method: Composition-based stats.
 Identities = 116/341 (34%), Positives = 161/341 (47%), Gaps = 19/341 (5%)

Query: 6   RVVITPGEPAGIGPDLVVQ---------LAQREWPVELVVCADATLLTNRAAMLGLPLTL 56
            +++T G+  G+GP+L  +           +      +V+      L     + G+    
Sbjct: 19  PLLVTMGDVNGLGPELACRVLGADGGRGALRYGVASPVVLLGSGKSLDTFMTLCGINGRF 78

Query: 57  -----RPYSPNSPAQPQTAGTLTLLPVALRAPVT--AGQLAVENGHYVVETLARACDGCL 109
                      +  +    G + L        VT   G+   + G      L  AC    
Sbjct: 79  WTAAADRQQLAALLEKARPGQVLLYEPPGMETVTVTPGKATADGGRAAGLALQEACSMLN 138

Query: 110 NGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQ--AKKVVMMLATEELRVALATTHL 167
           +G    ++T P+HK ++  AG  F GHTEF    +    + V M L  + LRV+L TTH 
Sbjct: 139 DGAATGVVTLPLHKAMLQQAGFDFPGHTEFLARHAGLRDEDVCMHLCGDVLRVSLVTTHP 198

Query: 168 PLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTII 227
            LRD+   +T   +   IA+    +R      +P + VCGLNPHAGE G +G E+   I 
Sbjct: 199 ALRDVPRLVTRQRVARCIALTVEFVRALGAGHKP-VAVCGLNPHAGESGKIGVEDESIIA 257

Query: 228 PVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLG 287
           P + E +  G+   GP PADT+F         AVLAMYHDQGL  LK   F   VN+TLG
Sbjct: 258 PAVREAKRMGLNAEGPYPADTIFYRAAQGEFAAVLAMYHDQGLAPLKLLHFSDAVNVTLG 317

Query: 288 LPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           LPF+RTSVDHGT  ++AGR  AD GSF +AL LA  M    
Sbjct: 318 LPFVRTSVDHGTGFDIAGRNTADTGSFESALRLAADMCARR 358


>UniRef50_A7IJ81 4-hydroxythreonine-4-phosphate dehydrogenase n=127
           Tax=Proteobacteria RepID=PDXA_XANP2
          Length = 350

 Score =  365 bits (938), Expect = 1e-99,   Method: Composition-based stats.
 Identities = 127/323 (39%), Positives = 173/323 (53%), Gaps = 9/323 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPV---ELVVCADATLLTNRAAMLGLPLTLR 57
           MV    +V++ G+PAGIGPD+ +    +   +     +V  D   L  R   LGL + L 
Sbjct: 1   MVAPAPLVLSLGDPAGIGPDITLTAWAQRRELGLPAFLVAGDPEALKARVRQLGLTVPLA 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
             +    A    A  L ++P    +    G     +   VV +L  A      G  AAL+
Sbjct: 61  E-TGPEDAAGHFAEALPVMPAGPASTALPGAPDASSAPCVVASLEAALGLVQAGRAAALV 119

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQ-----AKKVVMMLATEELRVALATTHLPLRDI 172
           T P+ K V+   G PF GHTEF   R+      A   VMM+ +E+L V  AT HLP  D+
Sbjct: 120 TNPLAKSVMYAGGFPFPGHTEFLAARAARPGRPAPHPVMMIWSEQLAVVPATIHLPYADV 179

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
              +T  LL E   I+  D+  +FG+A PR++ CGLNPHAGE G +GTE+   + P +  
Sbjct: 180 PGHLTIDLLVETGRIVAGDMARRFGLAHPRLVFCGLNPHAGEEGTLGTEDEAIVRPAVEA 239

Query: 233 LRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIR 292
           L+ +G+   GPLPADTLF P+     D  + MYHDQ L   K   F  GVN+TLGLPFIR
Sbjct: 240 LKREGIDARGPLPADTLFHPQARAGYDVAVGMYHDQVLIPAKTLAFHDGVNVTLGLPFIR 299

Query: 293 TSVDHGTALELAGRGKADVGSFI 315
           TS DHGTA ++AG G+A+  S +
Sbjct: 300 TSPDHGTAFDIAGTGRANPSSLV 322


>UniRef50_Q475Q2 4-hydroxythreonine-4-phosphate dehydrogenase n=261
           Tax=Proteobacteria RepID=PDXA_RALEJ
          Length = 347

 Score =  365 bits (938), Expect = 1e-99,   Method: Composition-based stats.
 Identities = 176/343 (51%), Positives = 214/343 (62%), Gaps = 24/343 (6%)

Query: 1   MVKTQRVVITPGEPAGIGPDLV----VQLAQREWPVELVVCADATLLTNRAAMLGLPLTL 56
           M     + I+ GEPAGIGPD+     +QLA +       V  DA LL +RAA LG+    
Sbjct: 1   MPDPLALAISTGEPAGIGPDITIGALLQLAGQNGHARYHVLGDAHLLASRAAALGV---- 56

Query: 57  RPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNG----- 111
                ++  +    G + +  V L      G+L   NG YV+  L  A  GC        
Sbjct: 57  ----AHAWERRIAEGEVVIHHVPLAVACEPGRLDARNGPYVLSMLDAAIAGCRTHAGAPA 112

Query: 112 EFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE-------LRVALAT 164
            FAA++T PV K  INDAG+PFTGHTE+  E +   +VVMMLA  +       LRVALAT
Sbjct: 113 RFAAMVTAPVQKSTINDAGVPFTGHTEYLAEAAGVPRVVMMLAGPQPAHANAMLRVALAT 172

Query: 165 THLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEID 224
           THLPLR +ADA+T  LL E ++I+  DLR  FGIA PRILV GLNPHAGE GHMG EEI+
Sbjct: 173 THLPLRAVADAVTVPLLLETLSIIDADLRRWFGIARPRILVTGLNPHAGESGHMGREEIN 232

Query: 225 TIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNI 284
            I P L + R  G+   GP PADTLFQP++L +AD VLAMYHDQGL  LKY  FG GVNI
Sbjct: 233 VIEPALAQARDAGIDARGPYPADTLFQPRHLRDADCVLAMYHDQGLAPLKYGTFGHGVNI 292

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           TLGLPFIRTSVDHGTAL+LAG G+A+ GS I A+  A+ M  +
Sbjct: 293 TLGLPFIRTSVDHGTALDLAGSGQAEHGSMIEAIRSAVTMAGH 335


>UniRef50_C3JBU1 4-hydroxythreonine-4-phosphate dehydrogenase n=5 Tax=Bacteria
           RepID=C3JBU1_9PORP
          Length = 371

 Score =  365 bits (937), Expect = 2e-99,   Method: Composition-based stats.
 Identities = 105/330 (31%), Positives = 159/330 (48%), Gaps = 10/330 (3%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLP-LTLR 57
            +   + IT G+  GIG +++ +        E    ++   A         L +     R
Sbjct: 6   NRKPVIGITHGDINGIGYEVLFKAFAEANITELFTPIIYGSAEAEAFWRNYLTVETAPWR 65

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
             + +  A+      ++         V  G      G    + L RA +  LN    AL+
Sbjct: 66  KITTSGEAKEGEINLISC--TTQNVQVEVGVPTPLAGRCAFDALERAMEDALNNRIDALV 123

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKK---VVMMLATEELRVALATTHLPLRDIAD 174
           T P++K  +     PF GHT++   +   K+    +M+L + ++RVALATTH+ + ++A 
Sbjct: 124 TAPINKATMPQDLFPFKGHTDYLGAKCGLKENESPLMILTSGDIRVALATTHVAISEVAG 183

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            ++ +LL E +  +   ++  F I +PRI V  LNPH+G+ G MG EEI+ I P L + R
Sbjct: 184 LLSESLLLEKLQAIESSMQRDFDIEKPRIAVLSLNPHSGDRGLMGREEIEIITPTLQKAR 243

Query: 235 AQ-GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
            Q  +   GP  AD  +    L   DA+LA+YHDQGL   K      GVN T GLP IRT
Sbjct: 244 EQHKLLAFGPFAADGFWGSAELYKYDAILALYHDQGLAPFKSLFMNEGVNFTAGLPIIRT 303

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIK 323
           S DHGT  ++AG+  A   S   A+ LAI 
Sbjct: 304 SPDHGTGYDIAGKNLASSASLTAAIYLAID 333


>UniRef50_UPI00019F1502 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Citrobacter
           youngae ATCC 29220 RepID=UPI00019F1502
          Length = 336

 Score =  363 bits (933), Expect = 4e-99,   Method: Composition-based stats.
 Identities = 105/336 (31%), Positives = 164/336 (48%), Gaps = 9/336 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLR 57
           M     + I  GE AGIGP+LV ++          + ++  DA +L     + G+     
Sbjct: 1   MKNKPVLGIFLGEAAGIGPELVAKVIADGTAYQYCKPIIIGDARVLALGQKIAGVSFPWE 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
             +  S A+    GT+ L+ +     A +  G +   +GH   E+L    +   +G+   
Sbjct: 61  TITDPSQAKW-DNGTVQLIDLKNYDPADLVMGTIDTVSGHATGESLITCMELLKSGKIDG 119

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQA--KKVVMMLATEELRVALATTHLPLRDIA 173
            +  P++K      G         F E+     +   ++   ++L V   T H+P RDI 
Sbjct: 120 FVFAPLNKEAFKKGGWHIEDEHYLFAEQLGCLDRPRGLLNVLDDLWVFRVTGHVPFRDIV 179

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL 233
             ITP  +   + + +  LR   G   PRI V  LNPHAG+GG  GTEEID +IPV+ E 
Sbjct: 180 KYITPENVGRSVQLCYDTLRM-AGYDNPRIAVAALNPHAGDGGTCGTEEIDVLIPVIEEY 238

Query: 234 RAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
           RA+GM + GP+P DTLF   +    DAV+ ++HDQG    K   F  GV +  GLP+  T
Sbjct: 239 RAKGMDIYGPVPGDTLFIHAFNHEYDAVVTLFHDQGQIATKLHSFDVGVTVAGGLPYAIT 298

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           + +HGTA ++AG+G A   +   A+++A  M +  +
Sbjct: 299 TPEHGTAFDIAGKGIAKTLATERAISVAANMALTNK 334


>UniRef50_Q2CJB0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Oceanicola
           granulosus HTCC2516 RepID=Q2CJB0_9RHOB
          Length = 338

 Score =  360 bits (925), Expect = 4e-98,   Method: Composition-based stats.
 Identities = 109/332 (32%), Positives = 164/332 (49%), Gaps = 8/332 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVEL---VVCADATLLTNRAAMLGLPLTLRPY 59
               + +TPG+  GIGP+LV ++       E+   V+  DA ++   A   G+ LTL P 
Sbjct: 4   DRPVIALTPGDCTGIGPELVARIVHDGRLAEVARIVLVGDARVIERGARFAGVELTLAPV 63

Query: 60  SPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
              + A       + ++ +       +  G+    +G    +TLARA +    G+  A+ 
Sbjct: 64  ESPAKATFDGD-AVPIVDLGNIDPDALPLGEPDPTSGRLTGDTLARAIEFARAGKVDAIS 122

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERS-QAKKVVMMLATEELRVALATTHLPLRDIADAI 176
             P++K  +   G  F    + F            M   E   +   T+H+ LR+  D I
Sbjct: 123 FAPLNKRAMFLGGWEFPDEHKMFAHLLAHEGPFSEMNVLEGQWMTRVTSHVSLREAVDQI 182

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           T   +   + + H  +R K GI  PRI V  LNPH GEGG  G EEI+ I P + E+ A+
Sbjct: 183 TGPNICRALQLAHDTMR-KAGIETPRIAVAALNPHNGEGGLFGREEIEIIRPAVEEMAAK 241

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G+   GP P+DT++   +    D+VLAMYHDQG    K +GF +GV +T GL  I T+  
Sbjct: 242 GIDCTGPFPSDTVYLKAFAGEFDSVLAMYHDQGQIATKLRGFNKGVTVTAGLETIFTTPA 301

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           HGTA ++ G+GKAD G+  TAL LA  ++   
Sbjct: 302 HGTAYDIVGQGKADTGASETALRLAATLVRQK 333


>UniRef50_Q8DHB4 4-hydroxythreonine-4-phosphate dehydrogenase n=13 Tax=Cyanobacteria
           RepID=PDXA_THEEB
          Length = 341

 Score =  360 bits (925), Expect = 4e-98,   Method: Composition-based stats.
 Identities = 115/341 (33%), Positives = 165/341 (48%), Gaps = 30/341 (8%)

Query: 7   VVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + +T G+PAGIGP+++++       E   +  +     +L    A L     +       
Sbjct: 3   LALTLGDPAGIGPEILLKALAHLPSELLGQFFIAGTGQVLEETYARLCQQGQV------- 55

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
                    L L    L   +  G+ +V +G      L  A    + GE A ++T P+ K
Sbjct: 56  ---AIDPAQLQLWEHPLDEVIVPGRPSVASGTASFAYLKTAIQRAIAGEVAGIVTAPISK 112

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE------LRVALATTHLPLRDIADAIT 177
                AG  F G TE     +    V M+           L   LATTH+PL+ +  A+T
Sbjct: 113 ACWQAAGYSFPGQTEVLAHLTGTAHVGMLFLGRSPVTHWVLTTLLATTHIPLQAVPRALT 172

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ- 236
           P  L+E +A+L   LR +  +  PRI + GLNPH+GE GH+G EE+  +IP L   + Q 
Sbjct: 173 PEGLNEKLALLIQFLRERRHLERPRIAIAGLNPHSGEQGHLGQEEVTWLIPWLAAAQQQY 232

Query: 237 -GMKLNGPLPADTLF---------QPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITL 286
             ++L GP+P DTL+         +P      DA LA+YHDQGL  +K   F   VN T+
Sbjct: 233 PEVELIGPVPPDTLWIGAADAWWGRPAPATAYDAYLALYHDQGLIPVKMLAFREAVNTTI 292

Query: 287 GLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           GLPFIRTS DHGTA ++AG G AD  SF+ A+  A  +   
Sbjct: 293 GLPFIRTSPDHGTAFDIAGTGVADPQSFLAAIAWAQTLSKG 333


>UniRef50_D2TK32 Putative uncharacterized protein n=1 Tax=Citrobacter rodentium
           ICC168 RepID=D2TK32_CITRO
          Length = 348

 Score =  360 bits (924), Expect = 4e-98,   Method: Composition-based stats.
 Identities = 102/333 (30%), Positives = 163/333 (48%), Gaps = 6/333 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +    + +  G+PAG+GP+LV ++            ++ AD   +    A+ G     R 
Sbjct: 1   MSLPVIAMVLGDPAGVGPELVAKVLSDRALLQKAHFILIADRDEMKKGMAIAGREFPWRD 60

Query: 59  YSPNSPAQPQTAGTLTLLP-VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
            +  + A       L +    +  AP   G+   ++G Y++ETL +A +   +G   A+ 
Sbjct: 61  VAAPTTADLTVGEALLIHHRCSHPAPFEYGKATAQSGVYILETLKKALELTQSGLAQAIC 120

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVM-MLATEELRVALATTHLPLRDIADAI 176
             P++K  ++  G+ F     +F  +         +   + +    AT+H+P RDI   +
Sbjct: 121 FAPLNKQAMHMGGLAFRDELHWFAHQLDWTPFCCEVNVVDNVWAGRATSHIPFRDIVSNL 180

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           +   + + I ++H+ LR   G A PRI V  LNPH GE G  G EE   I P + + R Q
Sbjct: 181 SIDGVLDTITLMHNTLRQ-AGFATPRIAVQALNPHGGENGLFGDEEQTIIRPAMEKARQQ 239

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G+ + GP PADT ++    +  DAV++MYHDQ    LK  GF RGV +  GLP   T+ +
Sbjct: 240 GINVFGPYPADTTWKAMQTEKLDAVVSMYHDQFATALKMLGFERGVTVQGGLPVPITTAN 299

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           HGTA  L G+  A   +F  A+ LAI+M   +Q
Sbjct: 300 HGTAYNLYGQNAATPSAFEQAVLLAIRMAKGSQ 332


>UniRef50_Q1DF36 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Cystobacterineae RepID=Q1DF36_MYXXD
          Length = 346

 Score =  359 bits (922), Expect = 8e-98,   Method: Composition-based stats.
 Identities = 120/332 (36%), Positives = 165/332 (49%), Gaps = 12/332 (3%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRP 58
           +    V I+ G+ +GIGP++      +    +    V+  D   L    A          
Sbjct: 1   MGLPHVGISLGDVSGIGPEVTAAALTKPSVRKVLVPVIFGDGPTLARFPAFR----RYAR 56

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
             P++  + +    + +  +A +  V  G+ + E G      +  A D    G   AL T
Sbjct: 57  VEPSALGRVEGPTVVEVTRLAEKDRV-PGEPSREGGRAQYAFVTAAIDAMRAGHVDALCT 115

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            PV K  I+ AGIPF GHTE   E      V+M++    +RVALAT H+PL D+   +T 
Sbjct: 116 APVSKEQISRAGIPFMGHTEVLAEAFGV-DVMMLMDGPRVRVALATNHVPLADLPRLLTV 174

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             L   + +L   L    G  +PRI V GLNPHAGEGG +G EE++ I P + + RA  +
Sbjct: 175 DGLTAQLKLLSRSLEPVVG-HKPRIAVLGLNPHAGEGGLLGREEVEVIGPAIRKARAARV 233

Query: 239 KLNGPLPADTLFQPKYL--DNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
             NGP+PAD LF          DAVLAMYHDQGL   K   F R VN+TLGLP  RTS D
Sbjct: 234 DANGPIPADGLFAKPDEVGARYDAVLAMYHDQGLIPAKALDFERTVNVTLGLPVPRTSPD 293

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           HGTA  +AG+G+A     + AL  A ++    
Sbjct: 294 HGTAYAIAGKGEASCVPMVEALLKAAQLAGAR 325


>UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=10
           Tax=Proteobacteria RepID=PDXA2_PSEAE
          Length = 337

 Score =  359 bits (921), Expect = 1e-97,   Method: Composition-based stats.
 Identities = 104/334 (31%), Positives = 160/334 (47%), Gaps = 8/334 (2%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRP 58
               R+ +  G+PAGIGP+L+ +L           +V+ AD   +     + G     R 
Sbjct: 4   PSLPRLAMVLGDPAGIGPELIARLLADTEVREKAHIVLIADEAEMRRGMRIAGCEFPYRR 63

Query: 59  YSPNSPAQPQTAG-TLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                      A   L              + +   G Y +ETLA A +   +G   A++
Sbjct: 64  IDALETLDFADATPLLHPWLSQGGDEFPRSEASAVGGRYSLETLALALELTRSGRTDAIL 123

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAI 176
            GP++K  ++ AG+  +    +F ER             ++L  +  T+H+ L ++   +
Sbjct: 124 FGPLNKTSLHMAGMDHSDELHWFAERLGFGGPFCEFNVLDDLWTSRVTSHVALAEVPGLL 183

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           +   + E I ++   LR   G+A PRI VCGLNPH G+ G  G EE+D I P + + R Q
Sbjct: 184 SQERVGEAIRLIDDALRRS-GLARPRIGVCGLNPHNGDNGSFGREELDIIAPAVQKAREQ 242

Query: 237 GMKLNGPLPADTLFQP--KYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           G+  +GP PADT+F          DAV+ MYHDQG   +K  GF RGV +  GLP    +
Sbjct: 243 GIAADGPYPADTIFLKVQGDARAFDAVVTMYHDQGQIAIKLMGFSRGVTVQGGLPIPIAT 302

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
             HGTA ++AG+G+ADVG+   A  +A +M  + 
Sbjct: 303 PAHGTAFDIAGQGRADVGATRQAFEIACRMGRHK 336


>UniRef50_Q87AJ1 4-hydroxythreonine-4-phosphate dehydrogenase n=7 Tax=Xylella
           fastidiosa RepID=PDXA_XYLFT
          Length = 330

 Score =  357 bits (916), Expect = 5e-97,   Method: Composition-based stats.
 Identities = 155/325 (47%), Positives = 192/325 (59%), Gaps = 6/325 (1%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREW-PVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
             + + PGEPAG+GP+L V+L Q+      LV  AD              L L       
Sbjct: 4   PALALVPGEPAGVGPELCVRLVQQPRQDCRLVAFADPA----TLQAAAAALDLPLRLLPP 59

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A P+  G L +       P   G     N   V+  L  A   C++G    ++TGPVHK
Sbjct: 60  EALPERPGDLPIQAHCHVHPTRFGHPDPANAPAVIAALCEAASHCVHGVLHGIVTGPVHK 119

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
            VIN +GI +TG TE    +++   VVMMLA   LRVAL TTHLPLRD+ DAIT ALL  
Sbjct: 120 AVINQSGIHYTGTTELLAAQAEC-DVVMMLANPHLRVALVTTHLPLRDVPDAITAALLER 178

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            + I++  +   FGIA PRI V GLNPHAGE G++G EE+D +IPVL  LRA+GM L GP
Sbjct: 179 CLRIVNTAMCGDFGIATPRIAVLGLNPHAGEEGYLGREELDVVIPVLQRLRAEGMVLLGP 238

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           L ADT F P  L   DAV+AMYHDQGLPVLK+ GF + VNITLGLP+ R +VDHGTAL+L
Sbjct: 239 LSADTAFLPTKLIGYDAVVAMYHDQGLPVLKHSGFEQAVNITLGLPYPRVAVDHGTALDL 298

Query: 304 AGRGKADVGSFITALNLAIKMIVNT 328
           AGRG AD  S   A  L  ++  + 
Sbjct: 299 AGRGVADPSSLFAATALCARLAASR 323


>UniRef50_B8FR92 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Desulfitobacterium hafniense RepID=B8FR92_DESHD
          Length = 342

 Score =  356 bits (915), Expect = 6e-97,   Method: Composition-based stats.
 Identities = 91/327 (27%), Positives = 156/327 (47%), Gaps = 5/327 (1%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
              + +T G+PAG+GP++V + A +         ++  D  L      +  + +  +  +
Sbjct: 7   KPVIGVTMGDPAGVGPEIVAKAAAQGILAKDAHPIIVGDQRLFKRGMEIAKVRVDFQVAA 66

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
               A       +        A +  G+L  E G      +      C  G    +   P
Sbjct: 67  TLEEALTMDGIVVLDTRKFDAADLVMGELREECGRDAATNIQTCVQYCRQGLMDGICFAP 126

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
            +K  +  AG    G  +      Q       +   +++  A  T+H+P++DI+  +T  
Sbjct: 127 NNKAAMKKAGFVLHGAIDLLAGFFQFTGNRGELNVLDDVWTARVTSHIPVKDISARLTEE 186

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +   I +++  L+ + GIA+PRI V  LNPH GEGG  G EE++ I P + + +A G++
Sbjct: 187 GILNSIHLVNDTLK-RAGIAKPRIAVAALNPHGGEGGTCGREEVEVIAPTVEKAKAMGIE 245

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
            +GP PADTLF   +    DA + M+HDQG   +K +GF +GV +  GLP   T+  HG+
Sbjct: 246 TDGPFPADTLFIKLFNREYDAAVTMFHDQGQIAMKLKGFDQGVTVMAGLPNPVTTCSHGS 305

Query: 300 ALELAGRGKADVGSFITALNLAIKMIV 326
           A ++AG+G A+ G++  +  L +KM  
Sbjct: 306 AFDIAGKGIANPGAWGNSYGLVVKMAA 332


>UniRef50_A8ME07 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Archaea
           RepID=A8ME07_CALMQ
          Length = 325

 Score =  356 bits (914), Expect = 7e-97,   Method: Composition-based stats.
 Identities = 110/328 (33%), Positives = 167/328 (50%), Gaps = 18/328 (5%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
            R+ +T G+PAGIG ++V +   +     VEL +  +   L +   +LG+          
Sbjct: 2   PRIGVTLGDPAGIGYEIVAKALLKLSNPEVELTLIGN---LEHFKRVLGM-------LKI 51

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
           S         + +       P   G++  E G   +E++ R  +  + GE  AL T P++
Sbjct: 52  SDDVLNGVRFIDI----PGGPFEFGKVQEEAGRVSLESVRRGVELAMAGEIDALATAPIN 107

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K     AG  +  HT   +  +++K+ + +  T  LR+   T H+PL D    I  A + 
Sbjct: 108 KEAWIKAGSSYIDHTTLLQALTKSKESLTVFETRRLRILFLTRHMPLADAIKEIKAANVL 167

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ-GMKLN 241
             I      L+   G+   RI V  LNPHAGEGG +G EEID I P + E R + G+   
Sbjct: 168 NGIINASRVLKA-LGVRRGRIAVAALNPHAGEGGLLGREEIDEITPAVKEARVKYGIDAY 226

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP+PAD++F      + D VL++YHDQG    K   F R V++TLGLPF+RTSVDHGTA 
Sbjct: 227 GPIPADSVFHLAAQGHYDIVLSLYHDQGHIAAKTYDFKRTVSLTLGLPFLRTSVDHGTAF 286

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNTQ 329
           ++AG+G AD  S + A+  A++     +
Sbjct: 287 DIAGKGIADETSMLEAIRKAVRYANQYK 314


>UniRef50_A5WDW5 4-hydroxythreonine-4-phosphate dehydrogenase n=6
           Tax=Gammaproteobacteria RepID=A5WDW5_PSYWF
          Length = 374

 Score =  352 bits (905), Expect = 9e-96,   Method: Composition-based stats.
 Identities = 166/358 (46%), Positives = 216/358 (60%), Gaps = 31/358 (8%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWP----VELVVCADATLLTNRAAML------G 51
             +  +V+T GEPAGIG D+++QLA ++        L+V AD   L  R  ++       
Sbjct: 17  PSSASLVVTTGEPAGIGMDILLQLAMQQKLGELSYPLIVLADEAALQQRFELIYGSGVSK 76

Query: 52  LPLTL-RPYSPNSPAQPQTAGT-------LTLLPVALRAPVTAGQLAVENGHYVVETLAR 103
           L   L +     +  Q  +  T         LL V    PV AGQL V N   VV+ L  
Sbjct: 77  LSGPLWQRIESVNDLQQISGQTKGNALPQFYLLHVGCAEPVVAGQLNVNNAAMVVQQLQI 136

Query: 104 ACDGCLNGEFAALITGPVHKGVINDAGIP------FTGHTEFFEERSQAKKVVMMLATEE 157
           A     +G  +A++TGP+ K V+ DAGI       FTGHTEFF ++S  +KVVMMLA   
Sbjct: 137 AHQWAASGAASAIVTGPLQKSVLIDAGITLEDGGMFTGHTEFFMQKSGCQKVVMMLANSA 196

Query: 158 LRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGH 217
           ++VAL T H+PLR +ADAIT   + + + I+ +DLR KFG+  P+ILVCGLNPHAGE GH
Sbjct: 197 MKVALVTIHMPLRQVADAITADNVRQTVRIVLNDLRQKFGLPNPKILVCGLNPHAGEDGH 256

Query: 218 MGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQG 277
           +GTEEID I PVL E + QG  ++  +PADTLF  ++L + DAV+AMYHDQGLPVLK  G
Sbjct: 257 LGTEEIDIINPVLREFQQQGANISLAMPADTLFTTRHLQDCDAVIAMYHDQGLPVLKSHG 316

Query: 278 FGRGVNITLGLPFIRTSVDHGTALELAGRGKA------DVGSFITALNLAIKMIVNTQ 329
           FG  VN+TLGLP+IRTSVDHGTAL+LAG   A         S   AL +A  M+ + Q
Sbjct: 317 FGDTVNLTLGLPYIRTSVDHGTALDLAG-NSATSDVQPSSSSLWQALIMAEAMVHSQQ 373


>UniRef50_B8IXF1 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Methylobacterium nodulans ORS 2060
           RepID=B8IXF1_METNO
          Length = 336

 Score =  352 bits (903), Expect = 1e-95,   Method: Composition-based stats.
 Identities = 107/316 (33%), Positives = 167/316 (52%), Gaps = 9/316 (2%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREW---PVELVVCADATLLTNRAAMLGLPLTLRPYS 60
              + +T G+ AGIGP++VV+             +V  DA ++ +  A+ GLP  +R  S
Sbjct: 6   KPVIGVTMGDAAGIGPEIVVRALVEPEVREACHAIVIGDAGIMRDAVALTGLPCEIRAVS 65

Query: 61  PNSPAQPQTAGTLTLLPVALRA--PVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
             + A+ +  GT+ +L +   A      G+++   G   VE + RA    L+GE  A+ +
Sbjct: 66  SVAEAEFRD-GTIDVLDLRNIARSDFEPGRISAACGRAFVEYIRRAARMALSGEIDAVAS 124

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
            P +K  ++ AG  + G TE F E S++     +L   ++RV L ++H+ L      +T 
Sbjct: 125 APTNKEAMHAAGEIYPGQTEIFAEESRSTDPFTILTGGKMRVFLVSSHVSLSQAIALVTQ 184

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             +  VI      L+  +GI +P I V GLNPHAG+GG  G EEI+ +IPVL  LRA+G+
Sbjct: 185 PRIELVIRKAVASLKELWGIDDPLIGVAGLNPHAGDGGLFGREEIEHVIPVLERLRAEGI 244

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           ++ GP PAD+++        D V+ MYHDQG+  LK  G+   V +  G P IRT+  HG
Sbjct: 245 RIEGPGPADSVYDRADRGAYDGVIGMYHDQGVIPLKRYGY---VTVISGTPIIRTTAGHG 301

Query: 299 TALELAGRGKADVGSF 314
           TA ++A +G       
Sbjct: 302 TAYDIAWKGIGRANVM 317


>UniRef50_Q92TP3 4-hydroxythreonine-4-phosphate dehydrogenase 3 n=8 Tax=Rhizobiales
           RepID=PDXA3_RHIME
          Length = 348

 Score =  350 bits (900), Expect = 3e-95,   Method: Composition-based stats.
 Identities = 102/332 (30%), Positives = 160/332 (48%), Gaps = 6/332 (1%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQ---REWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
           +   + +  G+PAGI P+L  +L           ++   D  +L   A + G+ L L   
Sbjct: 12  RRPVIALAMGDPAGISPELTARLLALSDIRDAAHIIAIGDRRILDEGARVAGVTLDLEAA 71

Query: 60  SPNSPAQPQTAGTLTL-LPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
           S ++     TA  + + L     A V  G+  +  G +       A +    G+  A+  
Sbjct: 72  SLDALDNAGTARHVFVDLAHLDPADVVRGEATLAGGTFATRNFRTALELAHAGKADAVCF 131

Query: 119 GPVHKGVINDAGIPFTGHTEFFEE-RSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
            P +K  +  A   +     F  +  S   KV      E++  A  T+H+PL+D+A  ++
Sbjct: 132 TPFNKKAMRFAYPGYDDEIRFVADVLSFTGKVREFNVLEKVWNARVTSHIPLKDVASHLS 191

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              +   + +    L+   G  E +I V GLNPHAG+GG  G EEID I P + + RA G
Sbjct: 192 VEAILAELKLTQACLK-DAGYEEAKIAVAGLNPHAGDGGSFGMEEIDIIEPAVEKARALG 250

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
             + GP PADT+F     +  +AV+ MYHDQG   +K  GF +GV +  GLPF   +  H
Sbjct: 251 FNVEGPFPADTVFLRALKEGFNAVMTMYHDQGQIAMKIIGFDKGVTMMGGLPFPLCTPAH 310

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           GTA ++AG+G AD+G+   A+ LA +M    +
Sbjct: 311 GTAYDIAGKGIADIGATREAILLAARMAKKKR 342


>UniRef50_B1GZF5 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=B1GZF5_UNCTG
          Length = 318

 Score =  349 bits (896), Expect = 1e-94,   Method: Composition-based stats.
 Identities = 95/332 (28%), Positives = 156/332 (46%), Gaps = 21/332 (6%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRA-AMLGLPLTLR 57
           +   R+ IT G+PAG+G ++V +       +     V+  D   L       L   +   
Sbjct: 1   MTKPRLAITLGDPAGVGCEIVCRAVSSSAVKRVCSPVIFGDKQSLKRSLLKYLKNRMPFE 60

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
               ++                    V  G  + + G      + +A   C NG+  AL+
Sbjct: 61  FVESSNIG----------------DSVKMGAPSKKAGIIAASAIYKAVKYCANGKALALV 104

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAIT 177
           T PV K  +  +GI + GHTE     + +KKV MM+    +   + T H+P+  I++ I 
Sbjct: 105 TAPVSKESLKMSGIKYPGHTELLASLTNSKKVAMMMTCGNIHGVMVTRHIPVSKISENIK 164

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              + E + +  + LR K G    ++++CGLNPHAG+   +G EE   I+P    ++  G
Sbjct: 165 TKTIVEAVNLSVNFLR-KAGKKNIKVVLCGLNPHAGDNSILGFEEKKFILPAYKIIKKSG 223

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           + +  PL AD+ +        D + AMYHDQ +  LK     + VN+T+GLPF+RTS  H
Sbjct: 224 IDITKPLSADSAWLKTKNGQYDLICAMYHDQIMIALKCINAAKIVNVTIGLPFVRTSPGH 283

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           GTA  +AG+ +AD  + I A+  A +    ++
Sbjct: 284 GTAFNIAGKNEADASAMIEAILYAARWGKKSR 315


>UniRef50_Q2KXH9 4-hydroxythreonine-4-phosphate dehydrogenase n=9 Tax=Bacteria
           RepID=Q2KXH9_BORA1
          Length = 348

 Score =  348 bits (893), Expect = 2e-94,   Method: Composition-based stats.
 Identities = 103/329 (31%), Positives = 157/329 (47%), Gaps = 6/329 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR----EWPVELVVCADATLLTNRAAMLGLPLTLR 57
            +   + +T G+ AGIGP++  ++  +         LVV  D  ++T     LG    + 
Sbjct: 5   PQIPLLAVTLGDVAGIGPEITAKMLMKHDALRQKARLVVIGDVDVMTEAVRRLGGDPAIV 64

Query: 58  PYSPNSPAQPQTAGTLTLLPVALR-APVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
                +     T GT+ +       A V  G+++   G   V  +  AC     GE   +
Sbjct: 65  RRVERTADVSNTPGTIEVYQAGPSLAGVKLGEISAAAGDGSVRFVTTACALARAGEVDGI 124

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
           +T P++K  ++ AG  + GHTE        K   ++L+  +L +  ATTH+ LR   + +
Sbjct: 125 VTAPLNKAAMHAAGHKWPGHTELLAHEFGVKTFSLVLSAGDLYIFHATTHVSLRQAIEDL 184

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ 236
           TPA +  V+ +     +   G  +  + V GLNPHAGE    G E+ D + P + E  A 
Sbjct: 185 TPARVRAVLRLAGSFAKA-LGRGDQPVAVSGLNPHAGENRIFGDEDADILAPAVAEANAD 243

Query: 237 GMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
           G+   GP+PAD LF          V+A YHDQG    K      GVNIT+GLP +R SVD
Sbjct: 244 GILAAGPIPADALFPQAVRGKWQFVIACYHDQGHAPFKSVYGDDGVNITVGLPVVRVSVD 303

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMI 325
           HGTA ++AG+G A   S + A   A  ++
Sbjct: 304 HGTAFDIAGQGIAREDSLVLAAERAAALV 332


>UniRef50_D0RQA4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=alpha
           proteobacterium HIMB114 RepID=D0RQA4_9RICK
          Length = 329

 Score =  347 bits (892), Expect = 3e-94,   Method: Composition-based stats.
 Identities = 96/331 (29%), Positives = 160/331 (48%), Gaps = 10/331 (3%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQRE--WPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
            ++V +  G+P+GIGP+LVV+L   +      +VV  +  +L +   + G  +  +  + 
Sbjct: 2   KKKVAVLLGDPSGIGPELVVRLLNEDISNEANVVVIGEKKILEDGENISGKKVDFKFVTD 61

Query: 62  NSPAQPQTAGTLTL-LPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            +  +        L +          G+++ E+G  V+E +  A D     +  A+  GP
Sbjct: 62  FNEVKFNDKTKFFLDISKGTNRTYKRGEVSAESGKSVLEAMDYALDLAKEKKIDAINFGP 121

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVM-MLATEELRVALATTHLPLRDIADAITPA 179
           ++K  +   G  +    +F + + + K+        +    A  T+H+P++++ + IT  
Sbjct: 122 MNKTSLMMGGCQYNDEHDFMQNKLEMKEFCCEFNVVDNFWTARVTSHIPIKEVPENITKE 181

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            + + I +L   L+   GI  PRI V  LNPHA      GTEE D IIP + E +  G+ 
Sbjct: 182 NILKPIKLLDQTLKMS-GIKNPRIAVQALNPHAE----FGTEEKDEIIPAIEEAKKMGIN 236

Query: 240 LNGPLPADTLFQPKYL-DNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            +GPLP DT F   +   N D ++ MYHD     LK  GF RGV ++ GL    T+  HG
Sbjct: 237 ADGPLPCDTSFITAFKNKNHDCIVGMYHDALQCGLKAFGFDRGVTVSGGLTVPVTTPAHG 296

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           TA ++ G   A++   I +  LA+KM   TQ
Sbjct: 297 TAFDIVGTNTANLEPTINSFKLAVKMNSGTQ 327


>UniRef50_Q9CKG8 4-hydroxythreonine-4-phosphate dehydrogenase n=3
           Tax=Gammaproteobacteria RepID=PDXA_PASMU
          Length = 337

 Score =  346 bits (889), Expect = 6e-94,   Method: Composition-based stats.
 Identities = 96/333 (28%), Positives = 162/333 (48%), Gaps = 8/333 (2%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +    V +T G+PAGIGP+LV +L  +        +V+ AD   L     +         
Sbjct: 1   MTKSTVALTLGDPAGIGPELVAKLLAKQNIREKANIVLVADKDELEKGMEIAKAQFVYEE 60

Query: 59  YSPNSPAQPQTAGTLTLL---PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAA 115
            S +   Q +    + +L     +   P   G++  ++G Y++ETL  A +    G   A
Sbjct: 61  VSFHQLGQYEFKTGVPVLISHKSSHPKPFEYGKVTEQSGVYILETLKVALNLAKMGYVQA 120

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKK-VVMMLATEELRVALATTHLPLRDIAD 174
           +   P++K  ++  G+ +     +F E++   + V  +   +++  A  T+H+P +DI  
Sbjct: 121 ICFAPLNKQAMHKGGLRYRDELHWFAEQTDFNEFVCELNVVDDIWAARVTSHIPFKDIVP 180

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            ++   + + I +L+  L    G+  P+I V  LNPH GEGG  G EE+  I P + + R
Sbjct: 181 NLSIKGVFDCIHLLYRSLVQ-AGVENPKIAVQALNPHGGEGGVFGDEEMTIIQPGMEQAR 239

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
             G+ + GP P DT  +       + V++MYHDQ    LK  GF RGV +  G+P   T+
Sbjct: 240 KAGIDVYGPFPGDTTMREVERLKINGVVSMYHDQFSTALKILGFERGVTVQGGIPIPITT 299

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
            +HGTA +L G+  A   +F  A N+A++M   
Sbjct: 300 ANHGTAFDLHGKNIAIPTAFEAAFNIAVRMGQG 332


>UniRef50_C5CPN5 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Variovorax
           paradoxus S110 RepID=C5CPN5_VARPS
          Length = 354

 Score =  345 bits (887), Expect = 9e-94,   Method: Composition-based stats.
 Identities = 100/333 (30%), Positives = 160/333 (48%), Gaps = 8/333 (2%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREW---PVELVVCADATLLTNRAAMLGLPLTLR 57
           +    R+ +  G+P GIGP++ V+L  R+       +++ AD  +L     + G+ L   
Sbjct: 11  IPARPRIAVLLGDPGGIGPEMAVKLLARQRNLDAARVLLIADPVVLAAGERVAGVKLDPL 70

Query: 58  PYSPNSPAQPQTAGTLTLLPVALRAPVTA--GQLAVENGHYVVETLARACDGCLNGEFAA 115
                   + +  G  TLL            G+    +G    E L  A      G+   
Sbjct: 71  RIDGLDDLRFEH-GRPTLLQRDWMQGREPVLGESNEASGRASFEALELATAAVRRGQAEG 129

Query: 116 LITGPVHKGVINDAGIPFTGHTEFFEERSQAKK-VVMMLATEELRVALATTHLPLRDIAD 174
           ++  P++K  +   G+       + +ER      V     T  L  +  T+H+PL+D+A 
Sbjct: 130 IVFAPLNKHSLRLGGLVHEDELRYMQERFAVTGFVCEFNLTGSLWTSRVTSHIPLKDVAS 189

Query: 175 AITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELR 234
            IT   + + + I+   LR + G+A+PRI V GLNPHAG+GG +G EEI+ I P +  LR
Sbjct: 190 HITVEGVGDAVKIIASALR-RAGVAQPRIAVTGLNPHAGDGGSIGMEEIEIIAPAIERLR 248

Query: 235 AQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTS 294
           A+G    GP   DT+F      + DAV++MYHDQG   +K  GF +GV +  GLP    +
Sbjct: 249 AEGYDARGPFSPDTVFIGARRGDVDAVVSMYHDQGQIAMKLMGFEQGVTLHGGLPVPVAT 308

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
              G+A ++AG+G A +     A +L ++M   
Sbjct: 309 SASGSAFDIAGKGVAQIEGLQQAFDLCVRMASG 341


>UniRef50_B9XEU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=bacterium
           Ellin514 RepID=B9XEU4_9BACT
          Length = 330

 Score =  344 bits (883), Expect = 3e-93,   Method: Composition-based stats.
 Identities = 127/330 (38%), Positives = 169/330 (51%), Gaps = 13/330 (3%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPV---ELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           + I  G+  GIGP++ ++    E        ++  DA LL      L L L   PYS   
Sbjct: 5   IGICLGDVTGIGPEVTLKALAAEAGADDTRYLLIGDAGLLQKLNQGLNLNLDFHPYSGP- 63

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
                      L+P AL   +  G       +  V  L  A   CLN E   +IT PV+K
Sbjct: 64  -RNGGRIFVHDLMPGALPENLKPGAPEAA--NAAVAWLKDATQRCLNHELDGMITAPVNK 120

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEE-----LRVALATTHLPLRDIADAITP 178
             I  AG  F G TEF    + A +  MML   +     LRV LATTH+PL+ +++ +T 
Sbjct: 121 ESIIRAGHAFVGQTEFISNMAGADRSAMMLLGHDDRDRWLRVVLATTHVPLKAVSEKLTQ 180

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
           A +   I           G+   R+ VCGLNPHAGEGG +GTEEI  + P +   + + +
Sbjct: 181 AKVELAIERAAQSC-VDLGLPRARVAVCGLNPHAGEGGELGTEEITVVTPAVEACKRKNL 239

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            ++GP PAD LF   +  + D V+AMYHDQGL  LK  GF  G+N TLGLPFIRTS DHG
Sbjct: 240 DVHGPFPADALFHYVFKGDYDVVVAMYHDQGLVPLKMIGFENGINWTLGLPFIRTSPDHG 299

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNT 328
           TA  +AGRG A+  S I A+ LA ++    
Sbjct: 300 TAYNIAGRGIANPSSMIAAIRLAKQLARRK 329


>UniRef50_Q390F1 4-hydroxythreonine-4-phosphate dehydrogenase n=22
           Tax=Proteobacteria RepID=Q390F1_BURS3
          Length = 351

 Score =  343 bits (882), Expect = 4e-93,   Method: Composition-based stats.
 Identities = 97/336 (28%), Positives = 154/336 (45%), Gaps = 12/336 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPYSP 61
             V +T G+PAGIG +L+ +L  R        LV+  D  L      + G+ + + P + 
Sbjct: 11  PVVALTLGDPAGIGAELIAKLLARPDATTHANLVLIGDRWLWEAGQRVAGVTVDVEPVAS 70

Query: 62  NSPAQ---PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
            +  +            +     A VT GQ     G   +  L    D  L G+  A+  
Sbjct: 71  LAAVRNRPSTARAAFVAIDTIDPADVTVGQPGAAGGRSTLTVLDLCLDAALAGDIDAICF 130

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAIT 177
            P++K  +   G+        F E               EL  A  ++H+PL+D    ++
Sbjct: 131 APLNKYAMKLGGLKHEDELHHFAEALGVTGYFCEFNTLGELWTARISSHIPLKDAPGYLS 190

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              + +   +++  L    G+A P++ +   NPH G+GG  G EE+D I P + +L+++ 
Sbjct: 191 IERIEQASELIYRSLLAN-GVAAPKVAIAAFNPHGGDGGSCGREEVDIIEPAVRQLQSRD 249

Query: 238 MK----LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
                  +GP PADT+F      +  A++ MYHDQG   +K  GF RGV +  GLP   T
Sbjct: 250 WPTDAPFHGPFPADTIFLKAQAGDYQAIVTMYHDQGQIAIKLLGFSRGVTVQGGLPVPIT 309

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           +  HGTA ++AGRG ADVG+   AL +A +M    +
Sbjct: 310 TPAHGTAYDIAGRGTADVGATWQALQIACRMGAARR 345


>UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Octadecabacter
           antarcticus 238 RepID=B5KE47_9RHOB
          Length = 343

 Score =  343 bits (881), Expect = 4e-93,   Method: Composition-based stats.
 Identities = 102/332 (30%), Positives = 168/332 (50%), Gaps = 6/332 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +   ++ I PG+P+GIGP+L+ QL   +      ++++  D  +    A   G+ L L P
Sbjct: 6   MTKPKIAIIPGDPSGIGPELIAQLLASDGVSEAADILLVGDTHIWEQGARQAGVRLQLDP 65

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
            +  + A+      L  +     A V   ++ +++G   + TL +A D  + G    ++ 
Sbjct: 66  IAWANLAEFSGLRQLE-METIDVADVKVAEVTIQSGKSALRTLDQALDLAVAGIVDGVLF 124

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKV-VMMLATEELRVALATTHLPLRDIADAIT 177
           GP +K  +  AG+       +       K     +   ++L     T+H+ LR++AD IT
Sbjct: 125 GPFNKAALTAAGLNAEDEHRYMARYLGFKGYHSEVNVLDDLMTTRVTSHIGLREVADNIT 184

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
              + + I + H  L  K G + P + V  LNPHAG+ G  G EEID + PV+ E + + 
Sbjct: 185 ADGVRKAIMMAHDTL-AKAGKSRPHVAVAALNPHAGDNGKFGREEIDILAPVVAEYQGRH 243

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           M ++GP P+DT+F        DAV+ MYHDQG   +K  GF RGV +  GLP    +  H
Sbjct: 244 MHVSGPWPSDTVFLKAKAGEVDAVVTMYHDQGQIAIKLMGFDRGVTVAGGLPIPVVTPAH 303

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           GTA ++AG+  A+VG+   A NL +++ V  +
Sbjct: 304 GTAFDIAGQSVANVGATRNAFNLLLRLAVTHR 335


>UniRef50_B2KET4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Elusimicrobium
           minutum Pei191 RepID=B2KET4_ELUMP
          Length = 309

 Score =  342 bits (878), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 108/326 (33%), Positives = 159/326 (48%), Gaps = 21/326 (6%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREW---PVELVVCADATLLTNRAAMLGLPLTLRPYS 60
              + IT G+P GIGP++VV+  Q +        VV  D   L                +
Sbjct: 2   KPLIAITTGDPMGIGPEIVVKALQDKRVTDACTPVVIGDKKAL--------------IKN 47

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
                      T  +L   L    T G   V  G      +  A      GE  A++T P
Sbjct: 48  GLQEGAFSVVDTAAILTKPLPE--TPG-PTVYGGLTSFNAVTMASRITSKGEVKAMVTAP 104

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           + K   N AG+ +TGHT+F +E S+   V+MM  T +L V L + H  ++D++  IT   
Sbjct: 105 ISKESWNMAGVKYTGHTDFLKEFSRIDHVLMMFTTNKLTVGLVSEHAAIKDLSKEITSKK 164

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +     +L++ L +   + +PRI V  +NPHAG+GG +G EE + I P L+ L+ +   +
Sbjct: 165 IIHAAQLLNNFLISN-SVKKPRIGVSAVNPHAGDGGKLGMEEKEIIAPALSVLKKENFNI 223

Query: 241 NGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTA 300
            GP+P D L+        D +L MYHDQ L  LK       V++T GLPFIRTS  HGTA
Sbjct: 224 LGPMPVDALWTKYTKGAYDGILCMYHDQALLGLKLCAQEPIVHLTYGLPFIRTSPTHGTA 283

Query: 301 LELAGRGKADVGSFITALNLAIKMIV 326
            ++AG+ +AD  S I+A+  A+  I 
Sbjct: 284 FDIAGKNEADPSSMISAILYAVSHIK 309


>UniRef50_B4U950 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Aquificaceae
           RepID=PDXA_HYDS0
          Length = 310

 Score =  342 bits (878), Expect = 1e-92,   Method: Composition-based stats.
 Identities = 105/317 (33%), Positives = 168/317 (52%), Gaps = 15/317 (4%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPVE-LVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
           +   IT G+PAGIGP+L+++L +        V+  +  +L + +++LG        +   
Sbjct: 2   KIFGITMGDPAGIGPELILKLQKDMEDENAYVIYGEEYILKHASSVLGQNFYYEKVNSVD 61

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
             + +    + L+ ++L+  +   + +  +G   +  LARA    ++ +   ++T P++K
Sbjct: 62  DVKDKG---IYLISLSLKGAL---EPSPSSGKLAIAYLARATADAISKKLNGILTMPINK 115

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
                +G  F G TE+       K   MM+ ++ ++V LAT H+PL+DIA+AI   L+ +
Sbjct: 116 YFAKASGFSFNGQTEYLAFADNKKDFAMMMYSDAIKVVLATIHIPLKDIANAINVELIKQ 175

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            I ++   +   F    P I V GLNPHAGEGG +G EE   IIP + +       + GP
Sbjct: 176 KIKLIKDYIPKYFRF-IPTIKVLGLNPHAGEGGLIGDEEAKIIIPAIRD-----EDVVGP 229

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           +P DT F    +   D  L MYHDQGL   K   F +G N+T+GL F+RTS DHGTA ++
Sbjct: 230 IPPDTAFI--DIKKDDIFLCMYHDQGLIPFKMLAFDKGSNVTIGLSFLRTSPDHGTAYDI 287

Query: 304 AGRGKADVGSFITALNL 320
           A +G A V S   +L L
Sbjct: 288 AYKGLARVDSAGYSLEL 304


>UniRef50_UPI0000D5482C 4-hydroxythreonine-4-phosphate
           dehydrogenase,(4-(phosphohydroxy)-L-threonine n=1
           Tax=Psychroflexus torquis ATCC 700755
           RepID=UPI0000D5482C
          Length = 284

 Score =  340 bits (872), Expect = 5e-92,   Method: Composition-based stats.
 Identities = 122/284 (42%), Positives = 172/284 (60%)

Query: 42  LLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETL 101
           L   R A L   + +         +    G L ++  +  +    G+L   N  YV++ L
Sbjct: 1   LFVARTATLKKKVKILELDSLDQVKKNIKGHLQIIKTSKCSNTKPGKLYKSNAQYVLDNL 60

Query: 102 ARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVA 161
             +    +  +  AL+TGP+ K  I      FTGHTEF ++ +++K V+MMLA+++LRVA
Sbjct: 61  NYSIKQTMLNKRTALVTGPLSKENIISIDKSFTGHTEFIKKVTKSKDVLMMLASDQLRVA 120

Query: 162 LATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTE 221
           L+TTH+PL++++  IT  L+   + IL+ DL++KF I +P I V GLNPHAGE G +G E
Sbjct: 121 LSTTHIPLKNVSKKITKELIINKVKILNEDLQSKFNIHKPSIKVLGLNPHAGENGKIGRE 180

Query: 222 EIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRG 281
           E D I P + ELR + + ++ P+ ADT F  K L   DA L MYHDQ LPVLK   FGR 
Sbjct: 181 EQDHIKPAIRELRKKKINVSMPVSADTAFSNKSLKETDAFLGMYHDQVLPVLKTLSFGRS 240

Query: 282 VNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
           +NITLG+P IRTSVDHG AL++AG  K+D  S I A+  A K+I
Sbjct: 241 INITLGIPIIRTSVDHGVALDIAGTNKSDPSSLILAIKTAKKLI 284


>UniRef50_C5SNX7 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Asticcacaulis
           excentricus CB 48 RepID=C5SNX7_9CAUL
          Length = 319

 Score =  339 bits (871), Expect = 6e-92,   Method: Composition-based stats.
 Identities = 111/317 (35%), Positives = 161/317 (50%), Gaps = 19/317 (5%)

Query: 24  QLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRAP 83
              + +      V  DA LL +    LG    ++  +  S A       L +L   L AP
Sbjct: 6   AALRSQTQYAFTVLGDADLLAS----LG---PVQRLTDLSDAIAAFPDALPVLDRPLSAP 58

Query: 84  VTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEER 143
              G     +  ++   +    + CL+G    LIT P+ K V+  +G  F GHTE+  + 
Sbjct: 59  PLPGNPDPVHAPHITSWIREGVELCLSGAARGLITAPIAKSVLYASGFAFPGHTEYLGDL 118

Query: 144 S------QAKKVVMMLATEE------LRVALATTHLPLRDIADAITPALLHEVIAILHHD 191
           +        +  VMML   +      LRV LAT H PL ++   ++   +  +  + H  
Sbjct: 119 TAAAPYPGTRGPVMMLTAPDAVNESALRVVLATIHTPLSEVKAHLSAETVRTLAHVTHEA 178

Query: 192 LRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQ 251
           L   FG+A+PR+++ GLNPHAGE G +G EE+D + P++  L  +G+ ++GPLPADTLF 
Sbjct: 179 LIRDFGVAKPRLVLAGLNPHAGEDGTIGREEVDLLQPLVAALCNEGLDISGPLPADTLFH 238

Query: 252 PKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADV 311
            +     DA L +YHDQGL  LK   F  GVNITLGLP +RTS DHGT   + G+G A  
Sbjct: 239 AEARRTYDAALCLYHDQGLIPLKTLDFWGGVNITLGLPLVRTSPDHGTGFAIVGKGIARP 298

Query: 312 GSFITALNLAIKMIVNT 328
            S I A+  A  + +N 
Sbjct: 299 DSLINAIRAAHDISLNR 315


>UniRef50_A1TTF8 4-hydroxythreonine-4-phosphate dehydrogenase n=10
           Tax=Burkholderiales RepID=A1TTF8_ACIAC
          Length = 374

 Score =  339 bits (870), Expect = 9e-92,   Method: Composition-based stats.
 Identities = 123/341 (36%), Positives = 169/341 (49%), Gaps = 21/341 (6%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREWPV--ELVVCADATLLTNRAAMLGLP----LTLRP 58
             + +T G+PAGIGP+++ +  +          V      L   A  +  P    L L  
Sbjct: 26  PLLAVTQGDPAGIGPEIIAKAFRDAPDAMRGCFVVGGVETLRRAARCIARPGEPSLPLAL 85

Query: 59  YSPNSPAQPQTAGTLTLLPVALRA-PVTAGQLAVENGHYVVETLARACDGCLNGEFAALI 117
                 A+      + LLP+      +  G +  E G    + +  A    L GE A L+
Sbjct: 86  LQAPEEARAVPPRCVPLLPLPGLPGSIPFGAVHAEGGRAAADCVTWAARAALRGEIAGLV 145

Query: 118 TGPVHKGVINDAGIPFTGHTEFFEERSQAK--------KVVMMLATEELRVALATTHLPL 169
           T P+HK  ++ AG+   GHTE  +  +            V MMLA++ELR  L + H+ L
Sbjct: 146 TAPLHKEALSAAGVHHPGHTELLQAEAARHAGVPVADMPVRMMLASDELRTVLVSIHVSL 205

Query: 170 RDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPV 229
           R+   A+T   +   + I H  LR   G   PRI V GLNPHAGEGG  G EEI+ I P 
Sbjct: 206 REAIAAVTQDNVLRTLEITHAALRRGLGRG-PRIGVAGLNPHAGEGGLFGREEIEAIAPA 264

Query: 230 LNELRAQGMKLNGPLPADTLFQPKYL-----DNADAVLAMYHDQGLPVLKYQGFGRGVNI 284
           +   RA G+  +GP   DT+F             D VLAMYHDQGL  +KY G  +GVN+
Sbjct: 265 IAAARALGIDAHGPFAPDTVFMRARSTPQRPGEFDVVLAMYHDQGLIPVKYLGVDKGVNV 324

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMI 325
           TLGLP +RTS DHGTA ++AGRG AD  S + A+  A ++ 
Sbjct: 325 TLGLPLVRTSPDHGTAFDIAGRGVADASSLVEAVLAARRLA 365


>UniRef50_Q30S58 4-hydroxythreonine-4-phosphate dehydrogenase n=11
           Tax=Epsilonproteobacteria RepID=PDXA_SULDN
          Length = 307

 Score =  339 bits (870), Expect = 9e-92,   Method: Composition-based stats.
 Identities = 93/326 (28%), Positives = 153/326 (46%), Gaps = 26/326 (7%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           +   R+ I+ G+  G+G ++ ++  +        + C ++ +L   + +L   +      
Sbjct: 1   MSKVRIAISVGDLNGVGIEIAIKAHEEVSKLCAPLYCINSYMLNQASTLLNYKIPSN--- 57

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
                         +  V     V  G +  ++G Y  ++   A   C   +  A++T P
Sbjct: 58  ------------FEISEVGGEFAVKKGCVDKDSGRYSYDSFIHAISLCEQKKADAVVTMP 105

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           +HK     AG+ + GHT+   E  + +  +MML  +++ VAL + H+PL+D+A +I    
Sbjct: 106 IHKEAWMLAGLKYKGHTDLLREHFK-RDAIMMLGCQKMFVALFSEHIPLKDVASSIKYKK 164

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ--GM 238
           L +        L     +   R+ V GLNPHAG+ G +G EE+  I   +     +    
Sbjct: 165 LKQF------FLDFNNSVPNERVAVLGLNPHAGDNGVLGNEEL-IITKAIKSANKKVCFE 217

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           +  GPL  D  F P   +     +AMYHDQGL  LK   F   +N++L LP IRTSVDHG
Sbjct: 218 QFIGPLVPDIAFTPHIREKFKYFIAMYHDQGLAPLKALYFDESINVSLNLPIIRTSVDHG 277

Query: 299 TALELAGRGKADVGSFITALNLAIKM 324
           TA ++A   KA   S+I A+  AI +
Sbjct: 278 TAFDIAYEKKAKTLSYINAIKSAIAL 303


>UniRef50_B4D0B0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Chthoniobacter
           flavus Ellin428 RepID=B4D0B0_9BACT
          Length = 296

 Score =  337 bits (864), Expect = 5e-91,   Method: Composition-based stats.
 Identities = 110/329 (33%), Positives = 152/329 (46%), Gaps = 42/329 (12%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
             + + +T G+ AGIGP+++                           L      R    +
Sbjct: 4   SPKTIGLTLGDAAGIGPEIIKAALASGR-------------------LNKDFQYRVIGSS 44

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
             A                     G           E L  +    L GE AA++TGP+H
Sbjct: 45  DGA-------------------KPGAPTESTARAAREALEESARLALAGEIAAVVTGPIH 85

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K  +   G  F G TEF+  R++ +   M L    L VAL T H+PLR +A++++ + + 
Sbjct: 86  KARMQAIGFEFPGQTEFYAARAKEENFAMCLTGGALTVALVTAHIPLRTVAESLSSSEII 145

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ---GMK 239
            V  +L   L  +    +PR+ V GLNPHAGE G +G EEI+ I P +  LR +     +
Sbjct: 146 RVGHLLADFLLLRLD-RKPRLAVAGLNPHAGESGALGREEIELIEPAVALLRGELGDTAE 204

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
             GP+  DT+F        D VL MYHDQGL  LK   F  GVN+TLGLPF RTS DHGT
Sbjct: 205 CIGPISPDTVFHRAAGGEFDGVLCMYHDQGLIPLKLHAFDSGVNVTLGLPFPRTSPDHGT 264

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNT 328
           A E+AG+  A   S I A+NLA ++    
Sbjct: 265 AFEIAGKDIARPDSMIAAINLAAELAGKK 293


>UniRef50_A6FY83 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Plesiocystis
           pacifica SIR-1 RepID=A6FY83_9DELT
          Length = 327

 Score =  335 bits (860), Expect = 1e-90,   Method: Composition-based stats.
 Identities = 124/332 (37%), Positives = 168/332 (50%), Gaps = 25/332 (7%)

Query: 7   VVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQ 66
           +VIT G+P G+GP+L++++A        V+  +  +   RA + GL  +L        A 
Sbjct: 4   LVITQGDPDGVGPELLLRMAAEG-----VLLPEDRVFAGRAKLRGLAESL----TAEWAA 54

Query: 67  PQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARAC----DGCLNGEFAALITGPVH 122
           P  A    LL  +L                  E L R      +    G  AAL+T P+ 
Sbjct: 55  PGWAKLEPLLDPSLAER------DPSAPLGQFEALERGVDRVLEDVRKGAPAALVTAPID 108

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K V +  G+   GHTE+  ER+  +   M++A   +RV LAT HLPLR + +A+  A + 
Sbjct: 109 KAVASREGLRHPGHTEYLAERAGVEDFAMLMAGSTIRVVLATIHLPLRAVVNALDQAAIV 168

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK--- 239
              ++L   L   +G+AEP + V GLNPHAGEGG +G EE   I P +  L A   +   
Sbjct: 169 RAGSLLARSLVQDYGVAEPVVGVLGLNPHAGEGGLLGDEEQTLIAPAIEALGAWAAQAQI 228

Query: 240 ---LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVD 296
                GPLPADT F          ++AMYHDQGL   K   F  GVN+TLGLPF+RTS D
Sbjct: 229 PARFVGPLPADTAFHHNRGGRVHGLVAMYHDQGLGPFKLAHFSDGVNVTLGLPFVRTSPD 288

Query: 297 HGTALELAGRGKADVGSFITALNLAIKMIVNT 328
           HGTA ++AGRG AD  S   A+ LA  M    
Sbjct: 289 HGTAKDIAGRGVADASSMRAAIELARAMSRAR 320


>UniRef50_A1VC56 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Desulfovibrio
           RepID=A1VC56_DESVV
          Length = 428

 Score =  334 bits (858), Expect = 2e-90,   Method: Composition-based stats.
 Identities = 115/300 (38%), Positives = 155/300 (51%), Gaps = 12/300 (4%)

Query: 34  LVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGT-LTLLPVALRAPVTAGQLAVE 92
           L + A+A+L  +                   A     G  L   P      V  G+  V 
Sbjct: 136 LCIGAEASLFAHTRKAF-----WTRVDTPGDALAAGPGIYLYEPPGLDGLDVRVGEATVS 190

Query: 93  NGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQ--AKKVV 150
            G      L+ ACD    G    ++T P+HK +++ AG    GHTE+   R+     +V 
Sbjct: 191 GGCAAGVALSAACDLLCAGVVPGVVTLPLHKAMLHTAGFDVPGHTEYLARRAGLADDEVC 250

Query: 151 MMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNP 210
           M L  + LRV+L TTH PLR++AD +T   +   + +    +R   G+  P + VCGLNP
Sbjct: 251 MHLCGDRLRVSLVTTHPPLREVADLVTRERVLRCLRLTAAFVRA-LGLQGP-VAVCGLNP 308

Query: 211 HAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGL 270
           HAGE G +G EEI+ I P + + R +G+ ++GP PADTLF         AVLAMYHDQGL
Sbjct: 309 HAGESGRIGREEIEVITPAIEDARREGLAVDGPFPADTLFHRAAGGGYPAVLAMYHDQGL 368

Query: 271 PVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKM--IVNT 328
             LK   F   VN+TLGLPF+RTSVDHGT  ++AG G+A  GSF  AL LA  +      
Sbjct: 369 GPLKLLHFSDAVNVTLGLPFVRTSVDHGTGFDIAGTGRASTGSFTAALQLACMLCDAKGR 428


>UniRef50_B1ZQS3 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Opitutus
           terrae PB90-1 RepID=B1ZQS3_OPITP
          Length = 336

 Score =  334 bits (858), Expect = 2e-90,   Method: Composition-based stats.
 Identities = 120/353 (33%), Positives = 165/353 (46%), Gaps = 48/353 (13%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWP--VELVVCADATLLTNRAAMLGLPLTLRP 58
           +  T ++ +T G+PAG+GP+++            ++VV      L        LP  +R 
Sbjct: 4   LPNTTKLALTCGDPAGVGPEVIASWLASPAAVSQDVVVIGPPRWLE------SLPAGVRK 57

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
            +                        T G    +        + RA +GC  GEF  ++T
Sbjct: 58  IAVGLE----------------DFSATPGAPDADGALVAWAAIERAAEGCRQGEFCGVVT 101

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           GP+ K  +   G PF G TEFF  R    + VM  A   LRV LAT H+PL ++   + P
Sbjct: 102 GPISKERLAKIGYPFPGQTEFFAARWGG-EPVMAFAGGRLRVVLATWHIPLHEVGGRLGP 160

Query: 179 ALLHEVIA-------------------ILHHDLRTKFG----IAEPRILVCGLNPHAGEG 215
            LLH                       I  + +  ++G      +PRI VCGLNPHAGEG
Sbjct: 161 HLLHRAAQAATEIARIDCRAGAPVHAAIGANAVNDRWGQGIPPDKPRIGVCGLNPHAGEG 220

Query: 216 GHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKY 275
           G +G EE D I P L+ LR +   L+   PADT+F        D V+A+YHDQGL  LK 
Sbjct: 221 GLLGYEERDFIDPALDHLRTEFAGLSRCQPADTIFARALQGEFDVVIALYHDQGLAPLKT 280

Query: 276 QGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
             F   VN+TLGLPF+RTS DHGT   +AG+G A   SF  A+ +A ++I   
Sbjct: 281 IDFDESVNVTLGLPFVRTSPDHGTGFGIAGKGVARATSFANAVTVARQLIAAR 333


>UniRef50_A7HIW4 4-hydroxythreonine-4-phosphate dehydrogenase n=4
           Tax=Anaeromyxobacter RepID=A7HIW4_ANADF
          Length = 372

 Score =  333 bits (855), Expect = 5e-90,   Method: Composition-based stats.
 Identities = 116/328 (35%), Positives = 162/328 (49%), Gaps = 10/328 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            R+ ++ G+P+G+G ++  +        +   V  DA +L    A  GLP  L      +
Sbjct: 42  PRIAVSLGDPSGVGAEVTAKALAALAGQLVPYVFGDARVLARELAGSGLPCVL------A 95

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A     G L  +       V  G+     G   +  L  A +    G+  AL T PV K
Sbjct: 96  GAPLPPEGALVAVTRLPAGAVRPGRPDPRAGAAQLAALEAAFEAIRRGDADALTTAPVSK 155

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             +  A   F GHTE+ E R    + VMMLA E+L+VAL T H+    +  A+TP  + E
Sbjct: 156 AQVARALPGFVGHTEWLEARCGVGRSVMMLAGEKLKVALVTNHVAFWKLRRALTPERIAE 215

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGP 243
            +A+ H  LR   G+A PR+ +  LNPHAGE G  G EE   +   L+     G +  GP
Sbjct: 216 TLALTHRALREDLGLARPRLALAALNPHAGEEGAFGAEETTLLAGALSRAARAGARAQGP 275

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQG---FGRGVNITLGLPFIRTSVDHGTA 300
            PAD++F    L   DAV+A+YHDQGL  +K          VN+TLGLP +RTS DHG A
Sbjct: 276 FPADSVFFRAALGEFDAVVALYHDQGLIPVKLLDAVCADPAVNVTLGLPIVRTSPDHGVA 335

Query: 301 LELAGRGKADVGSFITALNLAIKMIVNT 328
            ++AG G A+  S I AL LA ++    
Sbjct: 336 YDIAGHGVANPASMIAALKLAARIAAVR 363


>UniRef50_B2UL26 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Akkermansia
           muciniphila ATCC BAA-835 RepID=B2UL26_AKKM8
          Length = 289

 Score =  333 bits (855), Expect = 5e-90,   Method: Composition-based stats.
 Identities = 104/327 (31%), Positives = 143/327 (43%), Gaps = 41/327 (12%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
              +  T G+ +GIGP+++                                         
Sbjct: 2   KPVIGYTLGDQSGIGPEVISAALASGEL------------------------------PE 31

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            A+ +  G         R  +  G+   E+  +  + L +A      G   A++T PV K
Sbjct: 32  DAEYRLIGK--------RVELPPGRPNAESAKHAFDHLEQAAHALREGTVDAVVTAPVCK 83

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
             +++AG  + G TEFF ER +     M L  + L V LAT H  L+ +   +    L  
Sbjct: 84  ETLHEAGFRWPGQTEFFAERLKTDNYAMCLTGKRLTVGLATIHTSLQSVPSLLETEELVR 143

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA--QGMKLN 241
           +  +L      K GI  PRI +  LNPHAGE G  G E+ + I P +  LRA       +
Sbjct: 144 IGTLLKDFCIRK-GIMRPRIALAALNPHAGEHGAFGDEDGNIIAPAVERLRAIHPDAAFD 202

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
           GP   D +++     N DAVLA YHDQGL  LK   F   VN+TLGLP  R S DHGTA 
Sbjct: 203 GPSVPDCVYRDAVEGNYDAVLAPYHDQGLIPLKLVDFHTAVNVTLGLPRPRLSPDHGTAF 262

Query: 302 ELAGRGKADVGSFITALNLAIKMIVNT 328
            LAG GKA+  S I A  LA++M    
Sbjct: 263 NLAGTGKANPSSTIHAFQLAVQMARRR 289


>UniRef50_Q31DF6 4-hydroxythreonine-4-phosphate dehydrogenase n=8
           Tax=Prochlorococcus marinus RepID=Q31DF6_PROM9
          Length = 343

 Score =  332 bits (852), Expect = 1e-89,   Method: Composition-based stats.
 Identities = 101/345 (29%), Positives = 160/345 (46%), Gaps = 32/345 (9%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLA---QREWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
              ++V++ G+ +GIGP+++++     +    ++ V+      L N          L+  
Sbjct: 8   NRLKLVLSVGDESGIGPEIILKALYSNEIPENIDFVIVGSKKNLQNTYR------KLKSL 61

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
              + A P+    +  L ++              G      L +A +       +AL+TG
Sbjct: 62  GLENLANPKNLN-IHDLEISSSDDSK-----ASYGDSSFNYLTKAIEIVKQYPNSALVTG 115

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLA------TEELRVALATTHLPLRDIA 173
           P+ K   + AG  F+G TE   +    K V M+           L   LATTH+ L ++ 
Sbjct: 116 PICKKSWSLAGHYFSGQTEVLAKSCGVKNVGMLFTAKSPITGWRLNTLLATTHIALCEVP 175

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL 233
             +T  L+H  + +      T   + +P   V GLNPHAGE G +G EE D +   L   
Sbjct: 176 KKLTTELIHSKLDLFKDFCSTY--VDKPSFKVSGLNPHAGEEGLLGNEEKDWLNDALIAW 233

Query: 234 RAQG--MKLNGPLPADT-------LFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNI 284
                 +KL GPL  D+        ++ K  +  D +LAMYHDQGL  +K       VN+
Sbjct: 234 NENNRDIKLLGPLSPDSCWNSSAKAWRNKDAEKHDGILAMYHDQGLIPMKVIALNYSVNM 293

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           T+GLPFIRTS DHGT  ++AG+G A+  S I A+  AI+M  +++
Sbjct: 294 TIGLPFIRTSPDHGTGFDIAGKGIAESQSMIEAIITAIEMTKSSR 338


>UniRef50_B5JFI3 4-hydroxythreonine-4-phosphate dehydrogenase n=1
           Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JFI3_9BACT
          Length = 303

 Score =  331 bits (850), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 110/324 (33%), Positives = 162/324 (50%), Gaps = 25/324 (7%)

Query: 5   QRVVITPGEPAGIGPDLVVQLA--QREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPN 62
           +++ IT G+P+G+GP+L+      +     E VV  +   +                   
Sbjct: 2   RKIAITCGDPSGLGPELIENCLDTRDYGDAEFVVFGNGPWVER----------------- 44

Query: 63  SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVH 122
                   GT+           T G    +     +  +  A   C++GE  A++TGP+ 
Sbjct: 45  ---LESDRGTIVSGVSLCERGFTPGIPEPDGARLAMAAMEAAAKACIDGECHAVVTGPIS 101

Query: 123 KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLH 182
           K +  + G  F G TEFF +R   K   M    E L++ LAT H+PLR +A+++T  +  
Sbjct: 102 KSLCAEVGYTFPGQTEFFADRWGGK-PSMAFVGERLKLCLATWHIPLRQVAESLTEKVFK 160

Query: 183 EVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ-GMKLN 241
             +      L  + GIA+P+ILVCGLNPHAGE G +G EEI+   P +  LR Q   ++ 
Sbjct: 161 HGVRSAVQ-LGQRSGIAKPKILVCGLNPHAGESGLLGREEIELFNPWIESLRGQLTAEIE 219

Query: 242 GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTAL 301
             +P DT F      + D V+AMYHDQGL   K   F  GVN++LGL ++R S DHGT  
Sbjct: 220 DCVPGDTAFARAIKGDGDVVVAMYHDQGLAPFKAVDFDSGVNVSLGLKYLRVSPDHGTGF 279

Query: 302 ELAGRGKADVGSFITALNLAIKMI 325
           +LAG+G A+ GS   A+ LA  M+
Sbjct: 280 DLAGKGLANAGSMHHAIRLACNMV 303


>UniRef50_Q17ZN0 4-hydroxythreonine-4-phosphate dehydrogenase n=16
           Tax=Epsilonproteobacteria RepID=PDXA_HELAH
          Length = 310

 Score =  328 bits (841), Expect = 2e-88,   Method: Composition-based stats.
 Identities = 89/321 (27%), Positives = 156/321 (48%), Gaps = 18/321 (5%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWP-VELVVCADATLLTNRAAMLGLPLTLRPYS 60
           +  +++ I+ G+  GIG +L+++  +      E +    + LL     +L     ++P +
Sbjct: 1   MVKKKIAISCGDIQGIGLELILKSHKEVSVLCEPLYLIHSELLGRANQLLTNAYEVKPLN 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
             +             P+      T G+++ ++G Y  E+  +AC+   + E  ++ T P
Sbjct: 61  AIAINS----------PLPSFNSSTIGKVSAQSGAYSFESFRKACELADDKEVDSICTMP 110

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           ++K     A IPF GHT+F ++R +  +++MML   +L V L + H+PLR ++  I    
Sbjct: 111 INKLAWQQAQIPFVGHTDFLKQRYKEHQIIMMLGCPKLFVGLFSDHVPLRAVSQLIQVKA 170

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           L + +       + +       I VCG NPHAGE G  G E+   +  +    +  G + 
Sbjct: 171 LVQFLLAFQKSTQAQI------IQVCGFNPHAGEEGLFGEEDEKILKAIQESNQTLGFEC 224

Query: 241 N-GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
             GPLPAD+ F P         ++M HD GL  LK   F   +N++L  P +R S DHGT
Sbjct: 225 FLGPLPADSAFAPNKRQITPFYVSMSHDVGLAPLKALYFDESINVSLNAPILRASTDHGT 284

Query: 300 ALELAGRGKADVGSFITALNL 320
           A ++A + KA+  S++ A+  
Sbjct: 285 AFDIAYQNKANNKSYLNAIKY 305


>UniRef50_Q7MAP7 PDXA HOMOLOG n=1 Tax=Wolinella succinogenes RepID=Q7MAP7_WOLSU
          Length = 307

 Score =  327 bits (840), Expect = 3e-88,   Method: Composition-based stats.
 Identities = 103/327 (31%), Positives = 162/327 (49%), Gaps = 24/327 (7%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCA-DATLLTNRAAMLGLPLTLRPYSPNSP 64
           ++ ++ G+P GIG ++ ++          ++   D  +L   +  LG+ +          
Sbjct: 2   KIFVSIGDPNGIGLEIALRSHSGVKDWGEIIYGVDERVLFEASQRLGIEVPQD------- 54

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
                   +   P+ L +P+  G ++ E G Y  E+  +  +    GE  A++T PVHK 
Sbjct: 55  --------MECDPLGLESPIAPGVISKEAGRYSFESFKKGVERAKKGEVQAIVTLPVHKK 106

Query: 125 VINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEV 184
             + AGIP+ GHTE   E    ++ +MM+  E   +AL T HLPL ++   +    +   
Sbjct: 107 AWSLAGIPYAGHTEALREMMG-EEAIMMMGKEGFFIALYTDHLPLSEVPQRVHERGVEGF 165

Query: 185 IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN-GP 243
           +  L H L      A     V GLNPHAG+ G +G EE      +    +A G +L  GP
Sbjct: 166 LRRLSHAL-----PAMKACGVLGLNPHAGDQGVLGKEEEGIKRAIERANQALGRELFFGP 220

Query: 244 LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALEL 303
           L  D  F P +    D  +AMYHDQGL  LK   F   +N++LGLPF+RTSVDHGTA ++
Sbjct: 221 LVPDVAFIPSWRAKFDHYVAMYHDQGLIALKILYFEESINLSLGLPFVRTSVDHGTAFDI 280

Query: 304 AGR-GKADVGSFITALNLAIKMIVNTQ 329
           A R G   + S+  A+ +A+K+  + +
Sbjct: 281 AYRGGNPSLLSYQNAIKMALKLGSDKR 307


>UniRef50_C9PYW4 Pyridoxal phosphate biosynthetic protein PdxA n=1 Tax=Prevotella
           sp. oral taxon 472 str. F0295 RepID=C9PYW4_9BACT
          Length = 371

 Score =  327 bits (838), Expect = 5e-88,   Method: Composition-based stats.
 Identities = 88/331 (26%), Positives = 139/331 (41%), Gaps = 8/331 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPY 59
              R+ IT G+  GIG +L+ +             +V     +       L L +     
Sbjct: 4   NKLRIAITQGDANGIGMELIFKTFASPEMFELCTPIVYGSPKVAAYHKKALNLDVNFSII 63

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
              + A+P+    L +        +  G    +      + + RA   C  G   A++  
Sbjct: 64  QDGAEAKPERLNLLAIADED--VKIEFGTPNEDAATLARKAIDRAVADCKAGVVGAIVNA 121

Query: 120 PVH-KGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           P+  K        P +      ++  +  +V+ M   E LR+   +  L ++D+A+ IT 
Sbjct: 122 PISEKHFFTTQEQPVSLSQYIAKQLGETNEVLEMSLNECLRITTLSGELAIKDVANEITK 181

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             +   + +LHH LR  F I+ PR+ V  LNP   +G     EE + I P + +L A G 
Sbjct: 182 ERIESAVRLLHHSLRRDFMISIPRVAVLALNPTLEDGP--CKEEQEVIAPAVKQLIADGY 239

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
              GP  AD+ F  +  D  DAVLAMYHDQ +   K      GV   +GL  + TS D  
Sbjct: 240 MAFGPYQADSFFGDREFDTFDAVLAMYHDQAMIPFKALSCEGGVRFIIGLSAVITSTDDE 299

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNTQ 329
                AG+G AD  +F  A+ LA+ +  N +
Sbjct: 300 ALDGKAGQGVADEIAFRHAIYLALDVSRNRK 330


>UniRef50_C0A8L4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Opitutaceae
           bacterium TAV2 RepID=C0A8L4_9BACT
          Length = 360

 Score =  325 bits (835), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 118/354 (33%), Positives = 165/354 (46%), Gaps = 54/354 (15%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQR--EWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            +  T G+PAG+GP+++     +  +   ++ V      L                    
Sbjct: 23  PLAFTCGDPAGVGPEIIAAWLAQHPDEYRDVAVIGPRRWL-------------------- 62

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
            + P +   + +        VT GQ          + + RA  GCLNGEF+ ++TGP+ K
Sbjct: 63  DSLPASIAKIVV--GGNDFVVTPGQPTEAGAVIAWDAMERAAAGCLNGEFSGVVTGPISK 120

Query: 124 GVINDAGIPFTGHTEFFEERSQA---------------------------KKVVMMLATE 156
             +   G  + G TEFF +R ++                            + VM  A  
Sbjct: 121 AWLARVGYKYPGQTEFFADRWRSASTIGQGGGGDRGNGGSGGRNGGNGKNGQPVMAFAGG 180

Query: 157 ELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAE--PRILVCGLNPHAGE 214
            L V L T H+PLR +A  +T A     I     +L   +G     PRI VCGLNPHAGE
Sbjct: 181 RLPVGLHTWHIPLRAVAAELTLANFTRSIR-AADELARVYGCEREHPRIGVCGLNPHAGE 239

Query: 215 GGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLK 274
            G +G +E D I P+L+ LRAQ   L+   P DTLF  +     D V+A+YHDQGL  LK
Sbjct: 240 EGLLGNQERDVIDPILDTLRAQFHGLSRSEPGDTLFGRQLRGEFDVVVALYHDQGLAPLK 299

Query: 275 YQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
              F   VNITLGL  +RTS DHGTA  +AG+GKA + SF  A+ +A ++I   
Sbjct: 300 VIDFDESVNITLGLAHVRTSPDHGTAFGIAGQGKASIRSFANAVTVARRLIRAR 353


>UniRef50_Q0C095 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Alphaproteobacteria RepID=Q0C095_HYPNA
          Length = 335

 Score =  323 bits (830), Expect = 4e-87,   Method: Composition-based stats.
 Identities = 112/334 (33%), Positives = 150/334 (44%), Gaps = 16/334 (4%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQ---REWPVELVVCADATLLTNRAAMLGLPLTLRP 58
                + +T G+PAG GP +                 V     L                
Sbjct: 4   PSLLPLALTMGDPAGCGPQITAAAWHALKDNPASAFYVVGWPGLY--------CGAPTEV 55

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
            +    A    +  L +L      PVT G+   +    ++ ++  A    L G   A++T
Sbjct: 56  IASPGDAARVFSRALPVLARGDARPVTPGKPDPDTAAGIITSIETATAHALAGIAGAVVT 115

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAK-----KVVMMLATEELRVALATTHLPLRDIA 173
            P+HK ++   G  F GHTEF             + VMML    LRVALAT H+P   + 
Sbjct: 116 NPIHKALLYGQGFRFPGHTEFIASLCATDGGAAPEPVMMLTGGGLRVALATIHMPYTAVP 175

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL 233
            A+    L  +  I    L  +FGI  PRI   GLNPHAGE G +G EE++ I P   EL
Sbjct: 176 AALADGRLQRIARITAAALTRQFGIPAPRIAFTGLNPHAGEDGTIGREEVEIINPAAAEL 235

Query: 234 RAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRT 293
           R +G+ ++   P DT+F        DAV+AM HDQGL  +K      GVN TLGLP IRT
Sbjct: 236 RNEGLDISDARPGDTVFAEALGGRFDAVIAMTHDQGLIPVKTLDMWGGVNTTLGLPIIRT 295

Query: 294 SVDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
           S DHGTA + A  G A   S I A++ A +   N
Sbjct: 296 SPDHGTAYDAAAAGTAKADSLIAAIHSAREQAAN 329


>UniRef50_B3DY74 Pyridoxal phosphate biosynthesis protein n=1 Tax=Methylacidiphilum
           infernorum V4 RepID=B3DY74_METI4
          Length = 294

 Score =  322 bits (827), Expect = 8e-87,   Method: Composition-based stats.
 Identities = 108/330 (32%), Positives = 162/330 (49%), Gaps = 40/330 (12%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           ++   + IT GEPAGIGP++V +  +                                  
Sbjct: 1   MRIPTIGITLGEPAGIGPEIVAKALKSNQI------------------------------ 30

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
                           +  +A   AG+L+  +     E L  A       E  A++T P+
Sbjct: 31  --------PKRFDYKVIGPKAKFEAGKLSSSSAAAAWEALEEAYKLWEKKEIQAIVTSPI 82

Query: 122 HKGVINDAGIPFTGHTEFFEERSQA--KKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           HK  +   G P+ G TEFF  ++     KV+M +++ ++ ++L +TH+ L     +IT  
Sbjct: 83  HKDNLFQIGFPYPGQTEFFAAKAGVPRDKVIMAMSSPKINLSLLSTHVSLYQAIKSITKD 142

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +     +L   L+     +   I + GLNPH GEGG+ G EE +T IP +NELR Q + 
Sbjct: 143 KIKLASVLLLEFLKKIKKKSNLTIAISGLNPHCGEGGNFGNEENETFIPAINELRNQELP 202

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           ++GP+  D++F+   L   D V+A YHDQGL   K   F  GVN+TLGLP IRTS DHG 
Sbjct: 203 VHGPVSPDSVFREVLLGKYDGVVASYHDQGLIPFKLVSFYSGVNVTLGLPLIRTSPDHGV 262

Query: 300 ALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           AL++AG+ KAD  S I+A+ LA K+I   +
Sbjct: 263 ALDIAGQNKADPRSLISAIKLACKLIPREK 292


>UniRef50_C3XMM1 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Helicobacter
           RepID=C3XMM1_9HELI
          Length = 317

 Score =  320 bits (820), Expect = 6e-86,   Method: Composition-based stats.
 Identities = 104/332 (31%), Positives = 164/332 (49%), Gaps = 35/332 (10%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWP-VELVVCADATLLTNRAAMLGLPLTLRPYSPNSP 64
           ++ ++ G+P G+G +++++  ++       V C D  LL   A +L   L          
Sbjct: 2   KIAVSIGDPNGVGLEILLKNHKKICKFCNPVYCVDKELLKEAAKILKFKLPKN------- 54

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKG 124
                  +  ++P  +   +T G +  E+G Y   +  +A +  L G+  A++T P+HK 
Sbjct: 55  ---LKCVSPKVMPSNIIPKITPGAIQKESGAYSYASFLQALNLTLVGKTKAMVTLPIHKK 111

Query: 125 VINDAGIPFTGHTEFFEERSQAK------------KVVMMLATEELRVALATTHLPLRDI 172
               AG+ + GHTE   +  + +            K +MML + +L VAL + H+PL+++
Sbjct: 112 AWQLAGVSYAGHTEALRDVFKFENMESKINGIQNQKAIMMLGSPKLYVALFSDHIPLKNV 171

Query: 173 ADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNE 232
              I    L E +      +     +  P   V GLNPHAG+ G +G E+ + I   +  
Sbjct: 172 PSLINIESLKEFLLDFAPYV-----LKMP-CGVLGLNPHAGDFGVLGDED-NVIREAIRL 224

Query: 233 LRAQ-GMKLN-GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPF 290
             A  G ++  GPL  DT F  K+L      +AMYHDQGL  LK   F   +NITL LP 
Sbjct: 225 ANASLGKEVFIGPLVPDTAFVGKHLRYY---VAMYHDQGLIPLKTLYFKESINITLNLPV 281

Query: 291 IRTSVDHGTALELAGRGKADVGSFITALNLAI 322
           IRTSVDHGTA ++A + KA+  S+I A+  AI
Sbjct: 282 IRTSVDHGTAFDIAYKNKAESKSYINAIKEAI 313


>UniRef50_C1A9L0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Gemmatimonas
           aurantiaca T-27 RepID=C1A9L0_GEMAT
          Length = 309

 Score =  320 bits (820), Expect = 6e-86,   Method: Composition-based stats.
 Identities = 109/323 (33%), Positives = 158/323 (48%), Gaps = 29/323 (8%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPA 65
            + IT G+P GIGP++V +  +        + A   ++      + + + L P+ P+  A
Sbjct: 11  TLGITLGDPRGIGPEIVGKALRDSRVEA--LGAFWQVIGPSGTGVPVDVDLGPWQPSGDA 68

Query: 66  QPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGV 125
           Q                           G      + RA      G    ++T P+ K  
Sbjct: 69  QADL---------------------ATGGRLAGLAVERATAMAQRGTIDGMVTAPLDKAA 107

Query: 126 INDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
           +   G  + GHTE     +      MMLA++ LRV LATTH+ LRD+  ++T A + +  
Sbjct: 108 LKAGGYDYPGHTEMLAALTGV-PTTMMLASDRLRVVLATTHIALRDVPVSLTAAAIRQAA 166

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
                 LR   GI  PRI++C LNPHAG+ G  G E+   + P+  EL      L+GPLP
Sbjct: 167 QATEAGLRADLGIPVPRIVLCALNPHAGDHGRFGDEDDTLLAPLAREL-----GLHGPLP 221

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
           ADT+F        DAV+A YHD G+  +K   FG  VNITLGLPF+RTS DHGTA+++AG
Sbjct: 222 ADTVFVRALRGEFDAVIAPYHDVGMTAIKVASFGSAVNITLGLPFVRTSPDHGTAIDIAG 281

Query: 306 RGKADVGSFITALNLAIKMIVNT 328
           +G A   S I A+  A+ ++   
Sbjct: 282 QGVASAESLIQAMTTAVGLVRRR 304


>UniRef50_B6BUU4 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=beta
           proteobacterium KB13 RepID=B6BUU4_9PROT
          Length = 310

 Score =  317 bits (813), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 108/329 (32%), Positives = 166/329 (50%), Gaps = 22/329 (6%)

Query: 1   MVKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           M   + + ++ G+P GIG DL   L ++     + +  D   L +RA +LG+        
Sbjct: 1   MNHIKTLAVSAGDPDGIGYDLCALLFKKNLNYHVDIYGDKEALLSRAKLLGIKN------ 54

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
                       + +  V     +   +        V+E++  A   C+  +  AL+T P
Sbjct: 55  -------LHNEKIKIYDVKNNKQIKNKR------ELVLESIKSATKSCIQKKSIALVTLP 101

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAK-KVVMMLATEE-LRVALATTHLPLRDIADAITP 178
           V+K  ++ +   FTGHTE+  E  +A+ + +M     + + VA  TTH+ L +    +  
Sbjct: 102 VNKEKLSTSKNLFTGHTEYIAELLKARNEPIMTFIGNKKIIVATNTTHMSLLNAIKNVEK 161

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             L   + +LH  ++ +  I  P+ILV GLNPHAGE    G EE   IIP +N+L+   +
Sbjct: 162 NNLINKLQLLHSCIKNQLKIKYPKILVTGLNPHAGENNLFGNEESKHIIPAINKLKELDI 221

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            L+GP+PADT      +   D +  MYHDQ L   K   F  GVN+TLGLP IRTSVDHG
Sbjct: 222 HLDGPVPADTALLKNNMRKYDCIYYMYHDQALCAFKTLFFDTGVNLTLGLPIIRTSVDHG 281

Query: 299 TALELAGRG-KADVGSFITALNLAIKMIV 326
           TA EL G+  +  + SF+ AL++A K+  
Sbjct: 282 TAEELVGKKERISIKSFLNALDIAEKLSH 310


>UniRef50_Q04UJ6 4-hydroxythreonine-4-phosphate dehydrogenase n=4 Tax=Leptospira
           RepID=Q04UJ6_LEPBJ
          Length = 316

 Score =  316 bits (810), Expect = 9e-85,   Method: Composition-based stats.
 Identities = 104/321 (32%), Positives = 160/321 (49%), Gaps = 18/321 (5%)

Query: 5   QRVVITPGEPAGIGPDLVVQ---LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           +R++IT G+P GIGP++ V    L ++   +  +V          +    LP      S 
Sbjct: 2   KRILITEGDPCGIGPEIFVHSLFLLRKISKIRPIVY-------FHSGKFPLPKEFVSISS 54

Query: 62  NSPAQPQTAGTL--TLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
           +S    +    +    L     + +  G+ +  +G   +  L  + +    G    LIT 
Sbjct: 55  SSEILKKGLFAIGHDSLSKKEVSSLKFGRPSALSGKSALAALVLSIEFQKEGGGD-LITL 113

Query: 120 PVHKGVINDAGIP-FTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           P+ K  +  +G+  F GHTEF  E  + K   M+++  +L+V   TTH+PL  + + +  
Sbjct: 114 PLSKEWVIASGVSTFRGHTEFLAEAYRTKTF-MLMSGNDLQVLPLTTHIPLVKVPEFLKE 172

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             L  +   +    +         I   GLNPHAGEGG +G EE + ++P++  L+ QG+
Sbjct: 173 IDLKSLANSILSCEKIDLQKP---IAFLGLNPHAGEGGKIGKEEEEILVPMIRSLKRQGL 229

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
           K+ GPL AD++F           LA YHDQGL   K     +GVN+TLGLPFIR S DHG
Sbjct: 230 KVEGPLSADSVFGESARKKFGLHLACYHDQGLIPFKMWEGKKGVNLTLGLPFIRVSPDHG 289

Query: 299 TALELAGRGKADVGSFITALN 319
           TA ++AG+G AD  SF+  LN
Sbjct: 290 TAFDIAGKGLADSTSFMECLN 310


>UniRef50_A5GHP5 4-hydroxythreonine-4-phosphate dehydrogenase n=11 Tax=Cyanobacteria
           RepID=A5GHP5_SYNPW
          Length = 342

 Score =  315 bits (808), Expect = 1e-84,   Method: Composition-based stats.
 Identities = 108/342 (31%), Positives = 159/342 (46%), Gaps = 30/342 (8%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYS 60
            Q +VI  G+PAGIG ++ ++        E    ++      L            LR  +
Sbjct: 11  NQHLVIALGDPAGIGMEVTLKALAHPRCPEGMKPLLVGCRASLKRT------HQRLRNLT 64

Query: 61  PNSPAQPQTAGTLTLLPVALR-APVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
               A P     L +  + +  APV  G      G      L+RA +    G   AL+T 
Sbjct: 65  GVPLADPDD---LDVEDLPIPGAPVNPGDAGAAGGAAGFRWLSRAVELVQAGHGRALVTA 121

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLA------TEELRVALATTHLPLRDIA 173
           P+ K   + AG P+ G TE   E  +A+   M+           L   LATTH+PL+ ++
Sbjct: 122 PIAKHTWHAAGHPYPGQTERLAELDRAESASMLFTAVSPSTGWRLNTLLATTHIPLQQVS 181

Query: 174 DAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNEL 233
            A+TPAL+   +  L    +       P +LV GLNPHAGE G +G+EE   + P+L++ 
Sbjct: 182 QALTPALVRSKLETLTRFCQRFN--PSPELLVAGLNPHAGEKGQLGSEEEQWLTPLLHQW 239

Query: 234 RAQG--MKLNGPLPADTLFQPKYLDN-------ADAVLAMYHDQGLPVLKYQGFGRGVNI 284
                 ++L GPLP DT +               D +LA+YHDQGL  +K   F + VN 
Sbjct: 240 AQANPTIRLKGPLPPDTCWLSAAQAWNRSDASGPDGILALYHDQGLIPVKLLAFDQAVNT 299

Query: 285 TLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIV 326
           TLGL F+RTS DHGT  ++A +G A   S ++A+  A  +  
Sbjct: 300 TLGLSFLRTSPDHGTGFDIAAQGIARCESMLSAIEAAWTLSQ 341


>UniRef50_A9GKN1 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Sorangium
           cellulosum 'So ce 56' RepID=A9GKN1_SORC5
          Length = 326

 Score =  313 bits (803), Expect = 6e-84,   Method: Composition-based stats.
 Identities = 111/314 (35%), Positives = 153/314 (48%), Gaps = 14/314 (4%)

Query: 18  GPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLT-LRPYSPNSPAQPQTAGTLTLL 76
           GP++ V  A        V+  D  +    A ++ +    L      +  +    G + L 
Sbjct: 2   GPEVAVAGAASVEGARCVLVGDEAITRRAARLVRVAARRLVVVDGRAAIEELAPGAIGLW 61

Query: 77  PVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIP-- 132
             +  L  P   G+   E+G   +  +  A D    G  AAL+TGP  K  I  +G P  
Sbjct: 62  AGSARLSRPSAFGRPEAEDGAAQLAWIDAATDLVREGVAAALVTGPASKHAIATSGAPGS 121

Query: 133 --FTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHH 190
             F GHTE    R +A++V M  A+ +L  AL TTH+PLR++ DA++P  +      L  
Sbjct: 122 ADFLGHTEHLGRRLRAREVTMAFASGKLVTALVTTHVPLREVPDAVSPREVARAAVWLAR 181

Query: 191 DLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQ------GMKLNGPL 244
            L    G   PR+ V  LNPHAGEGG +G EE   I P +     +        +L GP+
Sbjct: 182 -LLGDLGRERPRVAVAALNPHAGEGGLLGDEEQVRITPGIRLAARRLSRSGPAAELTGPV 240

Query: 245 PADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELA 304
            A+T F+       D V+AMYHDQ     K  GFG  VN+TLGLP +RTSVDHGTA +LA
Sbjct: 241 GAETAFRLAARGALDGVVAMYHDQATIPSKLLGFGEAVNVTLGLPIVRTSVDHGTAYDLA 300

Query: 305 GRGKADVGSFITAL 318
           G G+AD      A+
Sbjct: 301 GTGRADPRGMREAI 314


>UniRef50_UPI00019786BC 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Helicobacter
           cinaedi CCUG 18818 RepID=UPI00019786BC
          Length = 312

 Score =  311 bits (798), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 89/323 (27%), Positives = 147/323 (45%), Gaps = 24/323 (7%)

Query: 5   QRVVITPGEPAGIGPDLVVQLA-QREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            ++ I+ G+  GIG ++ ++         E V      ++ + A +LGL +  +     +
Sbjct: 2   PKIAISIGDINGIGLEIALKSHNAISQICEPVYVTHLEIVESAAKILGLSMP-KDMKCVA 60

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
             +             L   +  G ++ E+G Y  ++  +A     +    AL+T P+HK
Sbjct: 61  DFE-------------LCVDIQPGVVSKESGLYSYKSFLQAIKLTESRITQALVTLPIHK 107

Query: 124 GVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHE 183
               +AG+   GHT+   +   A   +MML  EE+ VAL T H+PLR ++ +I    +  
Sbjct: 108 KAWQEAGVKSIGHTQVLSQYFGA-DSIMMLGCEEMFVALYTDHIPLRKVSQSINQDSIKT 166

Query: 184 VIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLN-G 242
            +      +R    + EP   V GLNPH G+GG MG E+      V         +L  G
Sbjct: 167 FLLSFAGAVR----LNEP-CCVLGLNPHCGDGGLMGDEDKYITQAVCEANMVLNRELFFG 221

Query: 243 PLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALE 302
             P D+ F P         ++ YHD GL  LK   F + +N++L LP +RTSVDHG   +
Sbjct: 222 AYPPDSAFSPLNRKKFRYFVSQYHDVGLAPLKALYFEQSINVSLNLPILRTSVDHGVGFD 281

Query: 303 LAGRG--KADVGSFITALNLAIK 323
           +A +   K    S++ A+  A+ 
Sbjct: 282 VAYKKSVKIHTQSYMNAVKYAVD 304


>UniRef50_A9LFJ9 Pyridoxal phosphate biosynthetic protein (Fragment) n=1 Tax=Karenia
           brevis RepID=A9LFJ9_KARBR
          Length = 254

 Score =  310 bits (794), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 90/247 (36%), Positives = 130/247 (52%), Gaps = 4/247 (1%)

Query: 83  PVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGI-PFTGHTEFFE 141
            +   ++ V+ G      +  A    +      ++T P++K  + +AG   + GHTE  +
Sbjct: 7   KMPFERVQVKAGRCATLWVREATRLAVEKRIDGIVTAPLNKQAMYEAGFTQYGGHTEILQ 66

Query: 142 ERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEP 201
           E S AK   + L ++   VA  T H+P R+I+D + P  + E   IL   L+    + EP
Sbjct: 67  EGSGAKSSSLCLYSDGFTVAHVTCHIPFREISDRLNPQKVFETTRILRDFLKMIHPMKEP 126

Query: 202 RILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG-PLPADTLFQPKYLDNADA 260
           RI++ GLNPH       G EEI  I P +++  A G  ++  P+P DT+F        DA
Sbjct: 127 RIVMAGLNPHC--EPIFGDEEIRCIQPAIDDALALGWNVHRVPVPPDTVFLRTQRGEWDA 184

Query: 261 VLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNL 320
           V+AMYHDQG    K  GF   VN+TLGLP IRTSVDHGTA  +AG G AD  +  +A++L
Sbjct: 185 VVAMYHDQGHIPAKMGGFSNTVNVTLGLPIIRTSVDHGTAFNIAGTGTADESNLFSAIHL 244

Query: 321 AIKMIVN 327
              M   
Sbjct: 245 CTTMANG 251


>UniRef50_Q4FMQ9 4-hydroxythreonine-4-phosphate dehydrogenase n=3 Tax=Candidatus
           Pelagibacter RepID=Q4FMQ9_PELUB
          Length = 320

 Score =  308 bits (790), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 93/321 (28%), Positives = 148/321 (46%), Gaps = 6/321 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQ-REWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           +  + ++I  GEP  I  ++  +  +   +   L++     LL  +   L     +    
Sbjct: 1   MGKEPIIIVGGEPNSIFLEIFFKSLKTNIYKSPLIIIISKKLLQEQMKKLDFYFKINDID 60

Query: 61  PN-SPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
                    T   + L+ V  +      ++  ++  Y+ ET   A +       +  I G
Sbjct: 61  KELKDFSKLTNKKINLINVDYKFKKCFEKITSKSNKYIDETFKVALNFMKQNNLSKFING 120

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           PV K           G TE+  ++++ K V M++  + L V+  TTHL L+D+   IT  
Sbjct: 121 PVSKKSFLKG--KTLGITEYLAKKTKKKDVAMLIFNKNLSVSPLTTHLALKDVHKKITKQ 178

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            ++  + +++   +TKF    PRI + GLNPH  E     +EE   IIP + +LR +  K
Sbjct: 179 KIYTQVNLINKFYKTKFN-KLPRIAITGLNPHC-ESNFQNSEEDKVIIPAIKKLRLKNNK 236

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           +NGP PADT+F    L   D ++ MYHDQ L  +K       +NITLGLPF R S DHG 
Sbjct: 237 INGPFPADTIFTKFLLKKYDVIIGMYHDQVLSPMKALFGFDAINITLGLPFTRISPDHGP 296

Query: 300 ALELAGRGKADVGSFITALNL 320
              + G+  +D  S I AL  
Sbjct: 297 NYSMLGKNLSDPKSLIQALKF 317


>UniRef50_Q3V7R5 Pyridoxal phosphate biosynthetic protein n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q3V7R5_BDEBA
          Length = 316

 Score =  306 bits (785), Expect = 7e-82,   Method: Composition-based stats.
 Identities = 99/329 (30%), Positives = 154/329 (46%), Gaps = 18/329 (5%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGL-PLTLRPYS 60
           +   R+ +T G+  GIG ++  +      P + V        +     L L        +
Sbjct: 1   MSKLRIALTTGDVDGIGFEVTAKALHHLGPQKGVQFLLWRPDSASQKYLKLIDQKFERIT 60

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
            +  +Q        L+ +              +     + +  +   CL  E  AL T P
Sbjct: 61  VDDLSQALEIEGPYLIDI-------------ASDLAPAKWVELSAKACLKKEIHALATAP 107

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           + K  I  AG    GHT+  +  S AK V M    E+  V LAT HLP+++I   ++ ++
Sbjct: 108 LSKTSIKAAGFKDLGHTDILKRLSGAKHVHMGFVGEKFNVVLATAHLPVKEITKHLSFSV 167

Query: 181 LHEVIAILHHDLRTKFGIAEPR--ILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
           L E +   +  LR K   ++ +  I V GLNPHAGE G +G EE+     +++  + + +
Sbjct: 168 LAEALLNANE-LRKKLPASQAKKPIGVLGLNPHAGEAGLIGQEELLFFPELVSFAKEKKI 226

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQ-GFGRGVNITLGLPFIRTSVDH 297
              GPL  D  F P+        L++YHDQGL   K   G   GV++TLG+PFIRTSVDH
Sbjct: 227 PFEGPLVPDAAFFPQNWKKYSVYLSLYHDQGLIPFKMIHGQDSGVHMTLGIPFIRTSVDH 286

Query: 298 GTALELAGRGKADVGSFITALNLAIKMIV 326
           GTA ++ G+ KA+  S I A+  A+K+  
Sbjct: 287 GTAKDIFGKNKANPHSMIDAVRWAVKLAR 315


>UniRef50_D0E8J8 Pyridoxal phosphate biosynthesis protein n=1 Tax=uncultured
           bacterium HF130_AEPn_1 RepID=D0E8J8_9BACT
          Length = 304

 Score =  304 bits (780), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 96/334 (28%), Positives = 151/334 (45%), Gaps = 35/334 (10%)

Query: 1   MVKTQ-RVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
           M   + +++I  GE   IGP++  +                  L +++++         Y
Sbjct: 1   MTDNRMKIIICSGEKDSIGPEVTEKALLS--------------LYDKSSLRLNEFKFEIY 46

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
            P      +  G   L           G          ++ +  A +  L+G+  A++TG
Sbjct: 47  GPKEKFSKRALGLFEL--------SEPGN--------ALDFVREAVEQQLSGKAHAMVTG 90

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQ-AKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           P+ K         F GHT +  +      + +M     ++ V+  T HLP +++ ++I  
Sbjct: 91  PIDKLRWAKVLPGFLGHTGYLGQLCGHEDEPLMAFVGGKMIVSPLTIHLPFKEVPNSINI 150

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG- 237
             L + I +    L       + R+ VCGLNPHA + G MG EE   I P +  ++ +  
Sbjct: 151 DFLEKKIFLCVKLLEDIKKSKKVRLAVCGLNPHASDKGLMGDEEEKFISPAIKLVQDKFP 210

Query: 238 -MKLNGPLPADTLFQPKYLD-NADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
             ++ GPLP DT F   +++   D V A+YHDQ L   K   F  GVNIT GLP IRTSV
Sbjct: 211 EAEITGPLPGDTAFFKAFMEDEHDMVAAIYHDQALAPFKLLHFYDGVNITYGLPIIRTSV 270

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKMIVNTQ 329
           DHGTA ELAG+G AD  S   A+  A+++    +
Sbjct: 271 DHGTAYELAGKGAADHRSMENAILWAMRLASQKK 304


>UniRef50_C5T2H3 4-hydroxythreonine-4-phosphate dehydrogenase n=2
           Tax=Burkholderiales RepID=C5T2H3_ACIDE
          Length = 230

 Score =  302 bits (773), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 102/231 (44%), Positives = 139/231 (60%), Gaps = 14/231 (6%)

Query: 109 LNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAK--------KVVMMLATEELRV 160
           + G+ AAL+T P+HK  ++ AG+ F GHTE  +  + A          V MMLA++ELR 
Sbjct: 1   MRGDIAALVTAPLHKEALSAAGVDFPGHTELLQAEAAAHQGVPLADMPVRMMLASDELRT 60

Query: 161 ALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGT 220
            L + H+ LRD  DA+T   + + + I H  L    G A PR+ V GLNPH GEGG  G 
Sbjct: 61  VLVSIHVSLRDAIDAVTRDNVLQTLRITHAALLRSLGRA-PRMAVAGLNPHGGEGGLFGR 119

Query: 221 EEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKY-----LDNADAVLAMYHDQGLPVLKY 275
           EEI+ I+P + + RA GM ++GP   DT+F             D VLAMYHDQGL  +KY
Sbjct: 120 EEIEHIVPAVADARALGMDVHGPFAPDTVFMRARHTPQRAGEFDVVLAMYHDQGLIPVKY 179

Query: 276 QGFGRGVNITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIV 326
            G  +GVN+TLGLP +RTS DHGTA ++AG+G AD  S + A+ +A ++  
Sbjct: 180 LGVDKGVNVTLGLPLVRTSPDHGTAFDIAGQGVADAASLVEAVRVARQLAQ 230


>UniRef50_Q0RWE6 Terephthalate dihydrodiol dehydrogenase n=2 Tax=Bacteria
           RepID=Q0RWE6_RHOSR
          Length = 338

 Score =  299 bits (766), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 102/323 (31%), Positives = 145/323 (44%), Gaps = 11/323 (3%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQL---AQREWPVELVVCADATLLTNRAAMLGLPLTLRPY 59
              RV++T G+P GIGP+L V+    AQ       V+  D  ++   A   G+ +     
Sbjct: 4   SPPRVLLTIGDPNGIGPELAVKAVMAAQEHPAFNPVLVGDRCVVEPLAHRAGMTVR-ETA 62

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
              +         L + P         G++  E G   V  L RA      G    ++  
Sbjct: 63  DGLATPMADVVDLLPV-PSLPAGAFAPGRVTAEAGKATVAYLERAVRCLQGGGARGIVAC 121

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKK--VVMMLATEELRVALATTHLPLRDIADAIT 177
           P  +  +N AGI F G+     E   A+   V +ML    LR+  AT H  LRD    +T
Sbjct: 122 PHSETAVNAAGISFDGYPSLLAELVGARPDQVFLMLIGAGLRIVHATLHESLRDALGRLT 181

Query: 178 PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQG 237
           P L+H         L+ + GI  PRI V G+NPHAGEGG  G E++    P +  LRA G
Sbjct: 182 PELVHGAARAAVETLQAQ-GIPSPRIGVFGINPHAGEGGLFGDEDLRVTTPAVERLRAAG 240

Query: 238 MKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDH 297
           +  +GP+ AD           DA +AMYHDQG   +K         +T+G     +SV H
Sbjct: 241 IDASGPVGAD---LMLADPGFDAFVAMYHDQGHIPVKLLAGRSAAAMTIGAGVRFSSVGH 297

Query: 298 GTALELAGRGKADVGSFITALNL 320
           G   ++AG+G AD  + + AL L
Sbjct: 298 GAGFDIAGKGTADPDAVVGALRL 320


>UniRef50_A1RD08 Pyridoxal phosphate biosynthetic protein n=2 Tax=Actinomycetales
           RepID=A1RD08_ARTAT
          Length = 322

 Score =  295 bits (756), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 98/329 (29%), Positives = 151/329 (45%), Gaps = 14/329 (4%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPV---ELVVCADATLLTNRAAMLGLPLTLRP 58
           +   R ++  G+P GIGP+L V+ A           VV  D  ++ + A+  GL +    
Sbjct: 1   MSRARTLLPIGDPNGIGPELAVRAAAEMQAQGSEPPVVVGDRFVVAHYASRFGLSIR-ET 59

Query: 59  YSPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
                P       T+ LLPV     A    G++    G   VE +  A     +G  +A+
Sbjct: 60  IGTAEPIMH----TVDLLPVDAMPPAEFKPGRVCAAAGRATVEYVKTAVKSLRHGFGSAI 115

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAK-KVVMMLATEELRVALATTHLPLRDIADA 175
           +  P  +  IN AGI F+G+       S     V +ML  ++LR+   T H  + +    
Sbjct: 116 VAAPHSETAINSAGIVFSGYPSLLSASSGDHLPVFLMLIIDDLRITHVTLHCSVSEALQL 175

Query: 176 ITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRA 235
           + P  +   I      L+ K GI  PRI V G+NPHAGEGG  G E+   + PV+ +L  
Sbjct: 176 LNPRSVEAAIRATDATLK-KLGIERPRIGVFGINPHAGEGGLFGDEDARIVAPVVEKLAR 234

Query: 236 QGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSV 295
           +G+ + GP   D L       + D  +AM+HDQG   +K  G      + +G   + +SV
Sbjct: 235 EGLAVVGPTGCDVLL--ADRASYDGFVAMFHDQGHGPIKLLGGRESSALCIGQEIVFSSV 292

Query: 296 DHGTALELAGRGKADVGSFITALNLAIKM 324
            HG A ++AG+G AD+   + AL L   +
Sbjct: 293 GHGAAFDIAGQGIADIAPIVKALKLVASI 321


>UniRef50_Q5HTM4 4-hydroxythreonine-4-phosphate dehydrogenase n=15 Tax=Campylobacter
           RepID=PDXA_CAMJR
          Length = 364

 Score =  295 bits (756), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 92/366 (25%), Positives = 152/366 (41%), Gaps = 53/366 (14%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPL--------- 54
           +++ I+ G+  GIG +++V+  +              +LL   + +L L L         
Sbjct: 2   KKLAISIGDINGIGLEILVRSHEELSKICTPFYFIHESLLDKASKLLNLKLFNAKIVAFK 61

Query: 55  -----TLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCL 109
                        +  +  +        V     + AG++  ++G Y   +   A     
Sbjct: 62  DGKDYEFNFVKKENSLEIYSFYLPLDFKVDENFEIKAGEIDTKSGLYGFLSFKAASYFVY 121

Query: 110 NGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPL 169
                AL+T P+HK    DAG+ + GHT+   +  + K  +MML  +EL V L + H+PL
Sbjct: 122 EKHAHALLTLPIHKKAWEDAGLKYKGHTDALRDFFK-KNAIMMLGCKELFVGLFSEHIPL 180

Query: 170 RDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPV 229
             ++  IT   L   +   + +   K      ++ + G NPHAG+ G +G EE   +   
Sbjct: 181 AKVSKKITFKNLSIFLKDFYKETHFK------KMGLLGFNPHAGDYGVIGGEEEKIMEKA 234

Query: 230 LN------------------------------ELRAQGMKLNGPLPADTLFQPKYLDNAD 259
           +                                 + +G+ L  PL ADT F    L N +
Sbjct: 235 IAFVNAFLHSKKDEKFFKKALKDENLQKELLLNFKGKGVYLPHPLVADTAFTKTGLKNCN 294

Query: 260 AVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRG-KADVGSFITAL 318
            ++AMYHD  L  LK   F + +N++L LP IR SVDHGTA + A +  K +  S+  A 
Sbjct: 295 RLVAMYHDLALAPLKALYFDKSINVSLNLPIIRVSVDHGTAFDKAYKNAKINTKSYFEAA 354

Query: 319 NLAIKM 324
             AI +
Sbjct: 355 KFAINL 360


>UniRef50_O85987 4-hydroxythreonine-4-phosphate dehydrogenase n=8 Tax=Proteobacteria
           RepID=PDXA_SPHAR
          Length = 330

 Score =  291 bits (746), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 93/330 (28%), Positives = 145/330 (43%), Gaps = 18/330 (5%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQR---EWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
              V    G+PAGIGP++ V+             V+   A  +       G    LR   
Sbjct: 9   RPVVGTMIGDPAGIGPEVAVRALADGAVHTDSIPVLVGSAAAVERALDFTGTKARLRVMR 68

Query: 61  PNSPAQPQTAGTLTLLPVALRAP--VTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
                       + ++         +  G+     GH   + L        +G FAA I 
Sbjct: 69  GF-EKPSDDPAIIDVIDTGALPDGVLPLGEDTEAAGHATAQWLDELDALARDGSFAATIM 127

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           GP+  G +  A        +     +  +  +++L    LRVA  T H+ LR + D I+ 
Sbjct: 128 GPISTGSLKLA-----KKLDRVISPTPGESYLVLLTGP-LRVAHLTDHMSLRQVIDVISA 181

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
            L+   +  LH  +++ +GIA+PRI V GLNPHA     MG E+   I P +   RA+G+
Sbjct: 182 DLVATAVGQLHEAMQS-WGIAQPRIAVAGLNPHA-----MGDEDRLEIAPGIEAARARGI 235

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            + GP+  D++F+       D VLAM+HDQG   +K  GF     I +G P++  SV HG
Sbjct: 236 DVEGPIAPDSVFRHCIEGRYDMVLAMFHDQGHIAVKTWGFSGNSVIIMGPPYLHMSVAHG 295

Query: 299 TALELAGRGKADVGSFITALNLAIKMIVNT 328
           TA ++ G GKAD    ++A+    ++    
Sbjct: 296 TAYDIVGTGKADAAMMLSAMRTCGRLASGR 325


>UniRef50_Q4HSN6 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Campylobacter
           upsaliensis RM3195 RepID=Q4HSN6_CAMUP
          Length = 339

 Score =  285 bits (731), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 92/346 (26%), Positives = 146/346 (42%), Gaps = 32/346 (9%)

Query: 6   RVVITPGEPAGIGPDLVVQLAQR-EWPVELVVCADATLLTNRAAMLGLPL---------- 54
           +V I+ G+  GI  +LV++  ++             +LL     +L              
Sbjct: 2   KVAISIGDLNGISLELVLKSHKKLSQICTPYYFLHESLLKQGLNLLKKKEIALNLVEFSH 61

Query: 55  ----TLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLN 110
                      +   +  +  T   L +     + AG++  ++G Y   +   AC     
Sbjct: 62  AKISKFEKIKEDKNVKIFSFQTPLSLELNANFTIKAGEIDAQSGTYSFLSFEAACAFTHQ 121

Query: 111 GEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLR 170
               ALIT P+HK   N AGI F GHT+        K  +MML  ++L V L + H+ LR
Sbjct: 122 KHATALITLPIHKKAWNLAGISFRGHTDALRNFYG-KNAIMMLGCKKLFVGLFSEHIALR 180

Query: 171 DIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVL 230
           D++  I    L + +   + +   K      +I V   NPHAG+    GT   +    + 
Sbjct: 181 DVSSQIKLEPLTQFLIDFYQESGFK------KIGVLAFNPHAGD---FGTIGGEEESIIE 231

Query: 231 NELRAQGMKLNGP------LPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNI 284
             +R   + +         L AD+ F P  L     ++AMYHD  L  LK   F + VN+
Sbjct: 232 EAIRCANLHIQKEIYLPQILVADSAFTPNSLKKCSRLVAMYHDLALAPLKALYFEKSVNV 291

Query: 285 TLGLPFIRTSVDHGTALELAGRG-KADVGSFITALNLAIKMIVNTQ 329
           +L LP IRTSVDHGTA + A +  K    S+  A+ +A+ +    +
Sbjct: 292 SLNLPIIRTSVDHGTAFDKAYQNAKISTKSYKEAVKIALNLAKKRK 337


>UniRef50_B0SEJ8 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Leptospira
           biflexa serovar Patoc RepID=B0SEJ8_LEPBA
          Length = 314

 Score =  277 bits (709), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 103/321 (32%), Positives = 143/321 (44%), Gaps = 24/321 (7%)

Query: 5   QRVVITPGEPAGIGPDL---VVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           + ++I+ G+P  I  +L      L Q       +             + G      P  P
Sbjct: 2   KTILISEGDPTSINYELLESTFPLLQSLGKEHRIYL-----------IRGSHNQTLPSLP 50

Query: 62  NSPAQPQTAGTLTLL--PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
           N  A     G  ++             G+ +  +G    ++L  A D         LIT 
Sbjct: 51  NLTAPIDAPGFYSITWKGGGKSKSFVLGKPSRASGKMAYDSLLSAIDLQKETGAD-LITL 109

Query: 120 PVHKGVINDAGIP-FTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITP 178
           P+ K  +  AGI  F GHTE   +  + +   MM++ E+L V   TTH+PL+D+   +T 
Sbjct: 110 PLSKEWVVKAGINGFRGHTETLADAYK-RPTFMMMSGEKLNVIPLTTHVPLKDVVRELTK 168

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
               E    L   +     +  P+I   GLNPHAGEGG +G EE   +   ++ LR   +
Sbjct: 169 FNWKE----LGRAITQSPYLHHPKIGYLGLNPHAGEGGKIGKEETTLLKQGVSILRKAKL 224

Query: 239 KLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHG 298
            L GPL AD+ F P      D  LA YHDQGL   K     +GVNITLGL F R S DHG
Sbjct: 225 SLEGPLSADSAFLPDA-KPYDLYLAGYHDQGLIPFKLLEGKKGVNITLGLDFTRVSPDHG 283

Query: 299 TALELAGRGKADVGSFITALN 319
           TA  +AG+G AD    I+ L 
Sbjct: 284 TAFGIAGKGCADPTGLISCLE 304


>UniRef50_D0J448 Terephthalate dihydrodiol dehydrogenase n=5 Tax=Comamonas
           RepID=D0J448_COMTE
          Length = 306

 Score =  269 bits (688), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 83/315 (26%), Positives = 141/315 (44%), Gaps = 22/315 (6%)

Query: 11  PGEPAGIGPDLVVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQP 67
            G+P GIGP++ ++  ++    E   + V    + L   A +  +   L+          
Sbjct: 3   IGDPHGIGPEIALKALRQLSANERSLIKVYGPWSALEQAAQICQMESLLQDLIHEEAG-- 60

Query: 68  QTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVIN 127
                      +L  P   G++  + G   V++   A   C NGE  A+I  P H+  I+
Sbjct: 61  -----------SLAQPAQWGEITPQAGLSTVQSATAAIRACENGEVDAVIACPHHETAIH 109

Query: 128 DAGIPFTGHTEFFEERSQ--AKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVI 185
            AGI F+G+             +V +ML    LR+   T H  +R   + ++P L+   +
Sbjct: 110 RAGIAFSGYPSLLANVLGMNEDQVFLMLVGAGLRIVHVTLHESVRSALERLSPQLVVNAV 169

Query: 186 AILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLP 245
                   T  G+ +P++ V G+NPHA EG   G E+     P +  LR  G+ ++GP+ 
Sbjct: 170 QAAVQTC-TLLGVPKPQVAVFGINPHASEGQLFGLEDSQITAPAVETLRKCGLAVDGPMG 228

Query: 246 ADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAG 305
           AD +         D  +AM HDQG   +K         +++G   + +SV HG+A+++AG
Sbjct: 229 ADMV---LAQRKHDLYVAMLHDQGHIPIKLLAPNGASALSIGGRVVLSSVGHGSAMDIAG 285

Query: 306 RGKADVGSFITALNL 320
           RG AD  + +  + L
Sbjct: 286 RGVADSTALLRTIAL 300


>UniRef50_C3XJ32 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Helicobacter
           bilis ATCC 43879 RepID=C3XJ32_9HELI
          Length = 391

 Score =  260 bits (665), Expect = 5e-68,   Method: Composition-based stats.
 Identities = 90/402 (22%), Positives = 156/402 (38%), Gaps = 101/402 (25%)

Query: 9   ITPGEPAGIGPDLVVQLAQREWP-VELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQP 67
           ++ G+  GIG +L+++         + + C D  +L   A  L L +           + 
Sbjct: 3   VSVGDINGIGLELILRNHAEIAAYCKPIYCIDFEVLECAAKKLALQIP----------KD 52

Query: 68  QTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVIN 127
                L +  +     + AGQ+  ++G Y  ++  +A +  +  E + L+T P+HK    
Sbjct: 53  MYIHPLNMQDIFDDEIIKAGQICAKSGLYSFKSFEKAVELSIEHEAS-LVTLPIHKYAWQ 111

Query: 128 DAGIPFTGHTEFFEERSQAKKVVM-----MLAT--------------------------- 155
            AGI + GHT++   R Q + ++M     M                              
Sbjct: 112 LAGIEYAGHTQYLRHRFQKEAIMMLGCKEMFVALFTDHIPLSKVSSLIHKEKLLQFFRDF 171

Query: 156 ----EELRVALATTHLP------------------LRDIADA------ITPALLHEV--- 184
                 L   L TT  P                  L++++        I   L+  +   
Sbjct: 172 YKAYSTLFTPLQTTQTPKNDTKHGTQDSKEIQLESLQELSSNTLKQNAINANLVKRLLYD 231

Query: 185 ------------------IAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTI 226
                             IA  +H L+ K    E +I V GLNPHAG+ G +G E++  I
Sbjct: 232 EKNIEKTIIEKPQDSIQEIAPHNHSLQPK---KELKIAVLGLNPHAGDNGVLGHEDM-II 287

Query: 227 IPVLNELRAQ-GMKLN-GPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNI 284
              +  +  + G ++  G +  D+ F P   +     +AMYHD GL  LK   F R +N+
Sbjct: 288 NECIGIINKEIGAEVFIGSIAPDSAFIPHNRERYSIFIAMYHDSGLAPLKALYFDRSINV 347

Query: 285 TLGLPFIRTSVDHGTALELAGR--GKADVGSFITALNLAIKM 324
           +L LP +RTS DHGT  + A +      + S++ +     ++
Sbjct: 348 SLNLPILRTSPDHGTCFDKAYQSNNNISMESYLESFRFLCQV 389


>UniRef50_UPI0000D53337 pyridoxal phosphate biosynthesis protein n=1 Tax=Psychroflexus
           torquis ATCC 700755 RepID=UPI0000D53337
          Length = 249

 Score =  260 bits (664), Expect = 8e-68,   Method: Composition-based stats.
 Identities = 94/249 (37%), Positives = 149/249 (59%), Gaps = 8/249 (3%)

Query: 5   QRVVITPGEPAGIGPDLVVQLAQREW----PVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           + ++ +PG+PAGIGPDL + L    +       +V   D  L  +RA  LG    +  ++
Sbjct: 2   KTIIYSPGDPAGIGPDLFLSLLNENFFRFIKANVVCIGDHELFASRAEKLGYSFEINTFT 61

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
             +    +    +  L +     ++ G+L   N  YV++ L    D C+N +   L+TGP
Sbjct: 62  DINDVNEK----VGCLEIIKCPDISCGRLNAINSEYVIKNLDFGIDTCVNSKDIGLVTGP 117

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPAL 180
           + K  I + G  F+GHTE   E++ +  V+M+LA+E L+VALATTH+PL  ++++IT  L
Sbjct: 118 ISKENIIEGGYSFSGHTERIMEKTNSDDVLMLLASERLKVALATTHIPLNKVSESITTDL 177

Query: 181 LHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKL 240
           +   + IL+H+L++KF I +P+I + GLNPHAGEGG +G EEI+TIIP + EL+A  + +
Sbjct: 178 IINKVKILNHELKSKFNIEKPKISLLGLNPHAGEGGKLGKEEIETIIPAVKELKASNVDV 237

Query: 241 NGPLPADTL 249
           + PL ADT 
Sbjct: 238 SMPLSADTA 246


>UniRef50_P94285 PdxA homolog (Fragment) n=1 Tax=Burkholderia cepacia
           RepID=P94285_BURCE
          Length = 258

 Score =  259 bits (663), Expect = 9e-68,   Method: Composition-based stats.
 Identities = 81/247 (32%), Positives = 121/247 (48%), Gaps = 14/247 (5%)

Query: 71  GTLTLLPVALRAPVTA--GQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVIND 128
           G + +L     AP     GQ +   G  VV  +A A     +G     I GP+    +  
Sbjct: 5   GRIVVLDPLDLAPHEYVTGQPSAAAGRAVVRWMALADRIAHDGLIGGWIMGPIDSTSLKL 64

Query: 129 AGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAIL 188
           AG   +       +  Q +   M   +  LRV   T H+PLRD+   +T   +  ++ ++
Sbjct: 65  AGEVAS------IDELQPEHSFMFRMSGRLRVVPLTEHIPLRDVPATVTFDAVLNLVTLV 118

Query: 189 HHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADT 248
           +  L+  +GI  PRI V GLNPHA     M  EE   I P + + RAQG+ + GP+  D+
Sbjct: 119 NERLK-DWGIEAPRIGVAGLNPHA-----MFEEEERIIGPAVEQARAQGIDVRGPVSPDS 172

Query: 249 LFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGTALELAGRGK 308
           +F+       DAV++MYHDQG   LK   F     + LG+P++R +V HGTA+ +AGR  
Sbjct: 173 VFRHGLDGRYDAVVSMYHDQGQIALKSAAFEGACTLYLGVPYVRATVPHGTAMGIAGRNL 232

Query: 309 ADVGSFI 315
           A   S +
Sbjct: 233 AQHHSMV 239


>UniRef50_UPI0000D53588 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Psychroflexus
           torquis ATCC 700755 RepID=UPI0000D53588
          Length = 262

 Score =  249 bits (637), Expect = 9e-65,   Method: Composition-based stats.
 Identities = 63/260 (24%), Positives = 115/260 (44%), Gaps = 6/260 (2%)

Query: 3   KTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPLTLRPY 59
           +  +V  T G+  GIGP++++              V+      L   A      ++    
Sbjct: 6   RKIKVGFTTGDMNGIGPEILLNSLLNSELLSTCIPVIYGSIINLNYTANHFSYKVSFNRI 65

Query: 60  SPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITG 119
           S    A       +          ++ G L  E G    E++  +      G+   L+T 
Sbjct: 66  SFAEEALEGKINVID--NFKNPPKISFGVLNKEMGFAAYESIKNSVKDLRAGKIDVLVTP 123

Query: 120 PVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA 179
           P++K  I+     F GHT++ + +       MM+ + +LRVAL T H+P+  + D+I+P 
Sbjct: 124 PINKEAIHSDEFQFMGHTDYIDGKIDGV-STMMMVSNDLRVALLTEHMPVSRVTDSISPE 182

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
           L+   I +L+  L   F   +P+I +  ++PHAG+GG +   +   I+P +   + +G+ 
Sbjct: 183 LVERKINMLNDTLIRDFQKEQPKIAILSIDPHAGDGGVISENDAQLIVPAVKISKDKGIL 242

Query: 240 LNGPLPADTLFQPKYLDNAD 259
           ++GP PAD+ F        D
Sbjct: 243 IDGPFPADSFFGSMEYKKYD 262


>UniRef50_A7T2T3 Predicted protein (Fragment) n=1 Tax=Nematostella vectensis
           RepID=A7T2T3_NEMVE
          Length = 371

 Score =  233 bits (596), Expect = 6e-60,   Method: Composition-based stats.
 Identities = 57/179 (31%), Positives = 96/179 (53%), Gaps = 1/179 (0%)

Query: 103 RACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVAL 162
            A      G    L+T P++K  I      F GHT++ +   +    +M++  ++ RV L
Sbjct: 1   AATAALKEGLVDVLVTAPINKYNIQSEDFKFPGHTDYLDSELEG-DALMLMIHDKFRVGL 59

Query: 163 ATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEE 222
            T H+P+ +I+ +++  LL + +  +   L   FG+ +P++ + GLNPH+G+ G +G EE
Sbjct: 60  LTDHIPVNEISKSLSEKLLMKKVGTIIKALEQDFGVVKPKVALLGLNPHSGDNGVIGDEE 119

Query: 223 IDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRG 281
              I P + ++   GM + GP  +D+ F     +  DA+LAMYHDQGL   K   FG+ 
Sbjct: 120 EKIIKPTVKKMFDSGMMVFGPYSSDSFFGSSQFEKYDAILAMYHDQGLIPFKTLSFGKA 178


>UniRef50_A1FAW6 Pyridoxal phosphate biosynthetic protein PdxA (Fragment) n=1
           Tax=Vibrio cholerae 2740-80 RepID=A1FAW6_VIBCH
          Length = 197

 Score =  218 bits (557), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 109/195 (55%), Positives = 140/195 (71%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           + ++R+++T GEPAGIGPDLV+ L+ ++WP +LVVCAD  LL  RA  LG+ + L  Y  
Sbjct: 1   MSSKRIIVTAGEPAGIGPDLVLALSAQDWPHQLVVCADKALLAQRATQLGIQVKLLDYQR 60

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
           ++P Q Q AGTL +  + L  PV AGQL   NGHYV++TL RA  GC+NGEF A++TGPV
Sbjct: 61  DNPVQAQQAGTLLVEHIPLAEPVVAGQLNPANGHYVLKTLERAAKGCMNGEFDAIVTGPV 120

Query: 122 HKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALL 181
           HKGVIN AG+ F+GHTEFF E+S+   VVMMLATE LR AL TTHLPL ++  AIT   L
Sbjct: 121 HKGVINRAGVAFSGHTEFFAEQSKTPLVVMMLATEGLRTALVTTHLPLAEVPQAITCERL 180

Query: 182 HEVIAILHHDLRTKF 196
            +++ ILH DL  K 
Sbjct: 181 EQIVHILHKDLVEKL 195


>UniRef50_A7C3I0 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Beggiatoa sp.
           PS RepID=A7C3I0_9GAMM
          Length = 222

 Score =  191 bits (485), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 49/198 (24%), Positives = 81/198 (40%), Gaps = 6/198 (3%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQRE---WPVELVVCADATLLTNRAAMLGLPLTLRP 58
           +K   + IT G+PAG+GP++VV+             +V  D +++ N          +  
Sbjct: 1   MKKPIIAITLGDPAGVGPEIVVKSFSNPKVYEVCRPLVIGDKSVIANALTFCNKTANIHI 60

Query: 59  YSPNSPAQPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAAL 116
                  + Q  GT+ L+ +     A +  G +    G    + + +A    + GE  AL
Sbjct: 61  IEKPKQGKYQ-LGTIDLVNLQNIEIAKLQIGTIQAMCGQAAYDYIEKAVQLAMIGEVEAL 119

Query: 117 ITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI 176
            T P++K  +  A I   GHTE  E  SQ    + M     +RV   + H+ LR   D +
Sbjct: 120 ATTPINKESLRAANIEHIGHTEMLETLSQTNDPLTMFEVRGMRVFFLSRHVSLRQSCDLV 179

Query: 177 TPALLHEVIAILHHDLRT 194
           T   + E        L+T
Sbjct: 180 TKERVLESSCRCTGALQT 197


>UniRef50_D0RPG9 Pyridoxal phosphate biosynthetic protein PdxA n=1 Tax=alpha
           proteobacterium HIMB114 RepID=D0RPG9_9RICK
          Length = 288

 Score =  174 bits (441), Expect = 5e-42,   Method: Composition-based stats.
 Identities = 59/241 (24%), Positives = 100/241 (41%), Gaps = 13/241 (5%)

Query: 65  AQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLAR----ACDGCLNGEFAALITGP 120
              +    + L     +      ++ ++  +Y  + L +      +     +   LI  P
Sbjct: 31  GDAKNFNKIYLFHKKYQKKFEFIRIELKKKNY-FQYLEKITKEGINLFKKKKIKYLINMP 89

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKV-VMMLATEELRVALATTHLPLRDIADAITPA 179
           ++K         + G TEF+ ++   K    M+L      V   TTH+ ++D+   IT  
Sbjct: 90  LNKK--KYLNNRYFGFTEFYSKKIDNKNNENMLLFNNNFSVCPLTTHIQIKDVDKKITHY 147

Query: 180 LLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMK 239
            +   +  + +  +         I+V GLNPHAG+  +  +++   I  ++    A    
Sbjct: 148 KIKIALNNIINFYKKIIKKKI-NIIVLGLNPHAGKDFNNNSKDKK-IEKLIFSKFANKNN 205

Query: 240 LNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGVNITLGLPFIRTSVDHGT 299
           + GP+ ADT F           L MYHDQ L   K +    G+NIT+G  F R S DHGT
Sbjct: 206 IKGPISADTAFTDTSNK---VFLGMYHDQVLIPFKMKNRFNGINITIGKKFYRLSPDHGT 262

Query: 300 A 300
           A
Sbjct: 263 A 263


>UniRef50_Q7X217 Putative 4-hydroxthreonine-4-phosphate dehydrogenase (Fragment) n=1
           Tax=Klebsiella pneumoniae RepID=Q7X217_KLEPN
          Length = 183

 Score =  172 bits (437), Expect = 1e-41,   Method: Composition-based stats.
 Identities = 41/183 (22%), Positives = 76/183 (41%), Gaps = 9/183 (4%)

Query: 1   MV---KTQRVVITPGEPAGIGPDLVVQLAQREWP---VELVVCADATLLTNRAAMLGLPL 54
           M+   K   V IT G+PAGIGP++ V     +      +  +     +++    ++G   
Sbjct: 1   MMSAEKKPVVAITIGDPAGIGPEITVATMMDKSVYDECKPFLIGSVPIISRAMKIMGCDF 60

Query: 55  TLRPYSPNSPAQPQTAGTLTLLPVAL--RAPVTAGQLAVENGHYVVETLARACDGCLNGE 112
            +   +    A+    GTL +L         +  G++    G   ++ + ++ +    G 
Sbjct: 61  AIHKIAHPQEARFSW-GTLDVLETGDYDCDSIEWGKVQKLAGQMSLDYVMKSIELGKAGL 119

Query: 113 FAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDI 172
              + T P+HK  I  AG    GHTE ++  +Q+   + M     LRV   + H+ L+  
Sbjct: 120 IDVVSTAPIHKEAIKLAGCKLPGHTEIYQVETQSDYGLTMFHVHNLRVFFVSRHMALKAA 179

Query: 173 ADA 175
            D 
Sbjct: 180 CDY 182


>UniRef50_Q47824 4-hydroxythreonine-4-phosphate dehydrogenase (Fragment) n=2
           Tax=Bacteria RepID=PDXA_ENTAG
          Length = 105

 Score =  169 bits (430), Expect = 9e-41,   Method: Composition-based stats.
 Identities = 50/104 (48%), Positives = 66/104 (63%)

Query: 223 IDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAVLAMYHDQGLPVLKYQGFGRGV 282
           I  + P +  ++AQGM + GP P DT+F     D  D V+AMYHDQG   LK  GF  GV
Sbjct: 1   IRILTPAVEAMKAQGMDVYGPCPPDTVFMQCNEDMYDIVVAMYHDQGHIPLKLLGFYDGV 60

Query: 283 NITLGLPFIRTSVDHGTALELAGRGKADVGSFITALNLAIKMIV 326
           NIT GLPF+RTS DHGTA  +A  GKA+  S   ++++A+K+  
Sbjct: 61  NITAGLPFLRTSADHGTAFNIAWTGKANPESMAISIDMAMKITR 104


>UniRef50_B6YQG1 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Candidatus
           Azobacteroides pseudotrichonymphae genomovar. CFP2
           RepID=B6YQG1_AZOPC
          Length = 326

 Score =  155 bits (393), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 55/320 (17%), Positives = 102/320 (31%), Gaps = 62/320 (19%)

Query: 22  VVQLAQREWPVE---LVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPV 78
           ++Q        E    ++   +T+L+    +  LP+          A      +L ++ +
Sbjct: 20  IIQTFSEVRIFELCVPIIYDYSTVLSYYRKIRRLPIRTTNIHN---ANKSIKNSLNIIDI 76

Query: 79  ALRA-PVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHT 137
           + +A P+T G+  +++   + E+  R       GE    +T       I           
Sbjct: 77  SNKALPMTVGKTNIKSNTAIGESFYRGLSDLKVGEIDVFVTSSTSTDSIQQIE------- 129

Query: 138 EFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFG 197
               E    KK + +L  +  R+A  +   P       I   +L E I  LH  L   F 
Sbjct: 130 ---SELLDEKKSLPILTNDYFRIAEISNSTP-------INIDILTEKIKNLHSTLLHDFM 179

Query: 198 IAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDN 257
           +  PRI +   N  A           + I         +G+        ++ F       
Sbjct: 180 VTFPRIAIVSENSPA-----------EIITDATQIAFREGIFCFSTFNPESFFNSDIYKK 228

Query: 258 ADAVL---AMYHD---QGLPVLKYQGFGRGVNITL--GLPFIRTSVDHGTALELAGRGKA 309
            DA L    M  +   Q +  +         N  L   +P++                 A
Sbjct: 229 FDAALIINCMSTNFIFQSIQPV-----SEQTNAILISNMPYVVA--------------IA 269

Query: 310 DVGSFITALNLAIKMIVNTQ 329
           +  S   ++ LAI +  N +
Sbjct: 270 NSTSLTPSIYLAIDVYRNRK 289


>UniRef50_C6SCG8 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Neisseria
           meningitidis alpha153 RepID=C6SCG8_NEIME
          Length = 150

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 50/128 (39%), Positives = 66/128 (51%), Gaps = 2/128 (1%)

Query: 2   VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
           +K     +T GEPAGIGPD+ + LA    P    V  D  LL  RA  LG  + LR + P
Sbjct: 1   MKQPVFAVTSGEPAGIGPDICLDLAFARLPCRCAVLGDKNLLRARAEALGKSVVLRDFDP 60

Query: 62  NSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPV 121
            S       G L +L +     V AG+L   N  YV++ L  A  G  +G F  ++T P+
Sbjct: 61  ESGGAAY--GELEVLHIPAAEAVEAGRLNPANAAYVLQLLDTALAGISDGIFDGIVTAPL 118

Query: 122 HKGVINDA 129
           HKG+INDA
Sbjct: 119 HKGIINDA 126


>UniRef50_B5YG77 Phosphate acyltransferase n=2 Tax=Bacteria RepID=PLSX_THEYD
          Length = 345

 Score =  110 bits (276), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 34/258 (13%), Positives = 81/258 (31%), Gaps = 30/258 (11%)

Query: 21  LVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVAL 80
           + V     ++  E+ +     ++ +    + L    +      P + +T G ++++P   
Sbjct: 4   IAVDAMGGDFAPEVNILGAYEVVQDIEVEIILVGDEKKIKSFLPEKKETKGIISVIPADD 63

Query: 81  RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFF 140
              +   +           ++ +A +    G+  A+I+      ++  + +         
Sbjct: 64  V--IQMDENISSALRRKNTSMRKAVELVKAGKADAVISAGHSGAMMALSFL-------LL 114

Query: 141 EERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TPALLHEVIAILHHDLRTKFGI 198
            +    ++  +      L+      H  L D    +   P  L +   +     +  F  
Sbjct: 115 GKLPNVERPAIATVMPCLK-----GHFILLDAGANVDCKPEHLVQFAFMGEAYHKALFNS 169

Query: 199 AEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL-PADTLFQPKYLDN 257
             P+I +  +    GE G  G E           L++  +   G +   D  F    +  
Sbjct: 170 QSPKIALLSI----GEEGSKGNE---LTKEAFKLLKSSRLNFVGNIEGKDIFFGQADVVV 222

Query: 258 ADAVLAMYHDQGLPVLKY 275
            D  +      G  VLK 
Sbjct: 223 CDGFV------GNIVLKV 234


>UniRef50_UPI000190527A 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Rhizobium etli
           Kim 5 RepID=UPI000190527A
          Length = 104

 Score =  104 bits (260), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 26/103 (25%), Positives = 46/103 (44%)

Query: 4   TQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNS 63
            + + IT G+P GIGP+++ ++     P + VV  D  ++     +L LPL ++P +   
Sbjct: 2   KKPIGITMGDPCGIGPEIIARVFADGLPEQAVVIGDTKVMERAVRVLNLPLQVQPIASVD 61

Query: 64  PAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACD 106
              P +     L    L   +  GQ+    G    + + RA D
Sbjct: 62  NVLPDSGLIAVLNVSDLPDDLPIGQVDARAGRASYDYVVRAID 104


>UniRef50_UPI00016999D5 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Endoriftia
           persephone 'Hot96_1+Hot96_2' RepID=UPI00016999D5
          Length = 103

 Score = 86.7 bits (214), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 36/62 (58%), Positives = 43/62 (69%), Gaps = 1/62 (1%)

Query: 127 NDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIA 186
           N+AG PFTGHTE+  +  Q+ + VMMLATE LRVALATTHLPL  ++  IT   L  VI 
Sbjct: 1   NEAGHPFTGHTEYLAQLCQS-EAVMMLATEGLRVALATTHLPLSQVSAQITRERLERVIR 59

Query: 187 IL 188
            L
Sbjct: 60  TL 61


>UniRef50_C2EXJ2 Putative uncharacterized protein (Fragment) n=4 Tax=Bacteria
          RepID=C2EXJ2_LACRE
          Length = 80

 Score = 81.7 bits (201), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 79/79 (100%), Positives = 79/79 (100%)

Query: 2  VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 61
          VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP
Sbjct: 1  VKTQRVVITPGEPAGIGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSP 60

Query: 62 NSPAQPQTAGTLTLLPVAL 80
          NSPAQPQTAGTLTLLPVAL
Sbjct: 61 NSPAQPQTAGTLTLLPVAL 79


>UniRef50_UPI000190303C 4-hydroxythreonine-4-phosphate dehydrogenase n=2 Tax=Rhizobium
          etli RepID=UPI000190303C
          Length = 97

 Score = 77.4 bits (190), Expect = 6e-13,   Method: Composition-based stats.
 Identities = 22/92 (23%), Positives = 41/92 (44%), Gaps = 3/92 (3%)

Query: 4  TQRVVITPGEPAGIGPDLVVQLAQREWPV---ELVVCADATLLTNRAAMLGLPLTLRPYS 60
          ++ + ++ G+PAGIGPD+ +    R   +      +  D  +L  RA  L L +++R   
Sbjct: 6  SRPLALSQGDPAGIGPDITLMAWLRRRELGLPPFFLIGDPDVLALRARQLNLAVSIREID 65

Query: 61 PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVE 92
              +    A  L ++ V +   V AG+    
Sbjct: 66 SADESTGSFADALPVMSVPVGIEVVAGEPHAA 97


>UniRef50_C2BLM4 Putative uncharacterized protein (Fragment) n=1 Tax=Corynebacterium
           pseudogenitalium ATCC 33035 RepID=C2BLM4_9CORY
          Length = 79

 Score = 71.3 bits (174), Expect = 4e-11,   Method: Composition-based stats.
 Identities = 20/74 (27%), Positives = 35/74 (47%), Gaps = 2/74 (2%)

Query: 66  QPQTAGTLTLLPVA--LRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHK 123
               AG + ++  +  L A +  GQ+    G    + +  A D    G   A++T P++K
Sbjct: 6   ASAAAGHIDVIACSPALPADLPLGQVHAAAGRGAYDYVCAAIDDAQAGRIRAIVTAPLNK 65

Query: 124 GVINDAGIPFTGHT 137
             ++ AGI + GHT
Sbjct: 66  KSMHAAGIDYPGHT 79


>UniRef50_A7I3D5 Phosphate acyltransferase n=2 Tax=Campylobacterales
           RepID=PLSX_CAMHC
          Length = 330

 Score = 56.6 bits (136), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 31/259 (11%), Positives = 74/259 (28%), Gaps = 36/259 (13%)

Query: 21  LVVQLAQREWPVELVVCADATLLTNR---AAMLGLPLTLRPYSPNSPAQPQTAGTLTLLP 77
           + +     ++  E ++      L  R   A ++G    +  + P           +  + 
Sbjct: 4   VAIDAMGGDFGCEPIIEGTIDALKEREFTAFLVGDQAQMEKFVPKE-----FINRVKFIQ 58

Query: 78  VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHT 137
                 +  G   V    +   ++ +A +   +GE  A+++       ++ A +      
Sbjct: 59  SNEIFEMKEGATNVL--RHKESSIYKAVELVRSGECQAVVSAGHSGATMSLATLRV---- 112

Query: 138 EFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TPALLHEVIAILHHDLRTK 195
              +  ++     +M  +   R  L        D+   +      + +   +     +  
Sbjct: 113 GRLKNVARPPIATLMPTSTGTRTLLL-------DVGANVDCKAEHIFQFGVMGEAYAKEI 165

Query: 196 FGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYL 255
            GI EP+I +       GE    G E           L+     +     +        +
Sbjct: 166 MGIKEPKIGILS----NGEEDGKGNE---VTKEAFKLLKKMKNFVGNAEGSQIFDGSMDV 218

Query: 256 DNADAVLAMYHDQGLPVLK 274
              D  +      G   LK
Sbjct: 219 IVCDGFV------GNIALK 231


>UniRef50_B1I2E9 Phosphate acyltransferase n=1 Tax=Candidatus Desulforudis
           audaxviator MP104C RepID=PLSX_DESAP
          Length = 335

 Score = 53.6 bits (128), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 38/272 (13%), Positives = 75/272 (27%), Gaps = 54/272 (19%)

Query: 20  DLV--VQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLP 77
           +++   + A REW  E+++  +   +   A      L L         Q   +  + +  
Sbjct: 16  EIIRGAEAAVREWGFEVILVGNEEAIAKYAD---SRLCLPVVRAPQVVQMDESPVVAVKR 72

Query: 78  VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHT 137
                                 ++ +A +   +G   A ++          +        
Sbjct: 73  KPDS------------------SVVKAVELVKDGRADAAVSAGHTGATFAASLFR----- 109

Query: 138 EFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TPALLHEVIAILHHDLRTK 195
                    ++  +       +         L DI   +   P  L +   +     R  
Sbjct: 110 --LGRIRGVERPALASVIPNEQGQTV-----LLDIGANVDCKPGHLLKFGIMGSLYARQV 162

Query: 196 FGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPL-PADTLFQPKY 254
            G+  PR+ +  +    GE    G E+  T+ P+            G +   D       
Sbjct: 163 LGVPNPRVGLLSI----GEEASKGNEQTLTVFPLFERA---PFDFVGNVEGGDLFSGRVD 215

Query: 255 LDNADAVLAMYHDQGLPVLKYQGFGRGVNITL 286
           +   D  +      G   LK    G GV  TL
Sbjct: 216 VVVCDGFV------GNIALKT---GEGVVRTL 238


>UniRef50_B1H0Q6 Phosphate acyltransferase n=1 Tax=uncultured Termite group 1
           bacterium phylotype Rs-D17 RepID=PLSX_UNCTG
          Length = 338

 Score = 51.6 bits (123), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 22/215 (10%), Positives = 56/215 (26%), Gaps = 26/215 (12%)

Query: 56  LRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVE----TLARACDGCLNG 111
           +         + +    L  L + +        +       V +    +L+       +G
Sbjct: 37  IEKILVGELLKYRGRYDLKSLNIEIINATEFITMDEHPAKAVRQKKDSSLSVCARLVADG 96

Query: 112 EFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRD 171
           +  A ++       ++ A         + +      +  +              H  + D
Sbjct: 97  KADAFVSMGNSGAAMSAALF-------YLKRIEGVLRPAISTVFPNFG-----GHCIIAD 144

Query: 172 IADAI--TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPV 229
           +   +  TP  L +   +          +  PR+ +  +    GE    G E     +  
Sbjct: 145 MGANVDCTPEYLLQFGIMASLFCEKVASVENPRVGLVSI----GEESTKGNE---LTLAA 197

Query: 230 LNELRAQGMKLNGPL-PADTLFQPKYLDNADAVLA 263
              L+   +   G +   D       +   D  + 
Sbjct: 198 FELLKKADINFIGNVEGRDIPGGKVDVAICDGFVG 232


>UniRef50_B4S1N6 Fatty acid/phospholipid synthesis protein n=1 Tax=Alteromonas
           macleodii 'Deep ecotype' RepID=B4S1N6_ALTMD
          Length = 270

 Score = 50.9 bits (121), Expect = 7e-05,   Method: Composition-based stats.
 Identities = 45/280 (16%), Positives = 92/280 (32%), Gaps = 56/280 (20%)

Query: 18  GPDLV----VQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTL 73
           GP ++    V+  Q    V   +C D   + +          L+P +    ++       
Sbjct: 6   GPPVILSAAVKAIQLHPDVHFTLCGDENTIKSG---------LQPLTDAERSRVTIKH-- 54

Query: 74  TLLPVALRAPVTAGQLAVENGHYVVET-LARACDGCLNGEFAALITGPVHKGVINDAGIP 132
                     V  G++         ++ + R  +   +GE  A ++   + G +      
Sbjct: 55  ------CSQVVEMGEVPTSALRNKKDSSMRRVIELVKSGEADACVSAG-NTGALLTLSF- 106

Query: 133 FTGHTEFFEERSQAKKVVMMLATEELRVALATTH--LPLRDIADAI--TPALLHEVIAIL 188
                   +  S   +  ++           T+H  + L D+   +  TP +L +   + 
Sbjct: 107 -----YLLKTLSGIDRPALINMMPT------TSHHNVFLLDLGANVNCTPEILFQYGVMG 155

Query: 189 HHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADT 248
               +   GI  PR+ +  LN   GE    G  ++ +   +  +    G+   G +  D 
Sbjct: 156 SVLAQEVAGIPSPRVAL--LN--VGEEDIKGNAQVKSADQLFKDA--PGINYIGYVEGDD 209

Query: 249 LFQPKYLDNADAVLAMYHD---QGLPVLKYQGFGRGVNIT 285
           +F        D V+    D   + L   K   F R V ++
Sbjct: 210 IFTDYA----DVVVT---DGLRKVLIATKRL-FYRAVFVS 241


>UniRef50_UPI00016A5E6C 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Burkholderia
          ubonensis Bu RepID=UPI00016A5E6C
          Length = 52

 Score = 50.1 bits (119), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 16/52 (30%), Positives = 21/52 (40%), Gaps = 5/52 (9%)

Query: 1  MVKT-QRVVITPGEPAGIGPDLVVQLAQREW----PVELVVCADATLLTNRA 47
          M      + IT GEPAG+GP+L  Q  +            V  DA L+    
Sbjct: 1  MTTPALHIAITTGEPAGVGPELTAQALRDAGERWPDARFTVLGDAALVAETR 52


>UniRef50_O67186 Phosphate acyltransferase n=8 Tax=Aquificales RepID=PLSX_AQUAE
          Length = 337

 Score = 49.7 bits (118), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 44/265 (16%), Positives = 82/265 (30%), Gaps = 50/265 (18%)

Query: 6   RVVITP--GEPAGIGP-DLV--VQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYS 60
           R+ +    G+ A   P ++V    LA +E   ++ +  D                 +   
Sbjct: 3   RIAVDCMGGDYA---PLEIVRGCILAAKELGYKIYLVGDKE---------------QIIP 44

Query: 61  PNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGP 120
               A+      L ++       V   +           +L  A      GE   L++  
Sbjct: 45  ILEKAKEHNNSLLEVVHAPD--KVEMHEPPSNVLKKKNSSLYVAGMLVRKGEADGLVSAG 102

Query: 121 VHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TP 178
            + G +   G    G     EE  +   + + L   + +  L        D+   +   P
Sbjct: 103 -NTGAVLAVGKFIVG----AEEEVERPSIGVALPNPKGKTVLI-------DVGANVDCKP 150

Query: 179 ALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGM 238
             L +   I H       GI  PR+ +  +    GE    G E +    P+   L+A  +
Sbjct: 151 KHLVQFAVIGHTYAEEILGIKNPRVGILSI----GEEEGKGNELVKETYPL---LKATKL 203

Query: 239 KLNGPLPADTLFQPKYLDNADAVLA 263
              G   A+   +  Y    D ++ 
Sbjct: 204 NFKG--NAEG--RDIYAGTFDVIVC 224


>UniRef50_C0GMU0 Fatty acid/phospholipid synthesis protein PlsX n=1
           Tax=Desulfonatronospira thiodismutans ASO3-1
           RepID=C0GMU0_9DELT
          Length = 352

 Score = 49.3 bits (117), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 30/252 (11%), Positives = 60/252 (23%), Gaps = 31/252 (12%)

Query: 17  IGPDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLL 76
           I P + V     +   ++V+             L L             Q      L +L
Sbjct: 4   IKPWIAVDAMGGDSGPDIVIPGSLEAARQDNLGLVLVGDQEKIEQALSKQKTGDLQLEVL 63

Query: 77  PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGH 136
                  +   + +         ++  A           +++       +          
Sbjct: 64  HAPEVVAMN-DKPSEALRRKKNSSIQAAFKSVREKTAHGVVSAGNSGATLACGMFT---- 118

Query: 137 TEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TPALLHEVIAILHHDLRT 194
                     ++  +       +         L D+   +   P  L +   +     R 
Sbjct: 119 ---LGRIKGIERPALASILPTEKKEPLV----LVDVGANVECKPYHLIQFGLMADVFARD 171

Query: 195 KFGIAEPRILVCGLNPHAGEGGHMGTEEI---DTIIPVLNELRAQGMKLNGPLPADTLFQ 251
              I  PRI V            +G EE      ++  +   R+  M   G +     F 
Sbjct: 172 VLHIKNPRIGVL----------TIGEEEGKGNKLVLETIKLFRSSSMNFIGNVEGRDFFA 221

Query: 252 PKYLDNADAVLA 263
                 AD V+ 
Sbjct: 222 ----GKADVVVC 229


>UniRef50_B1ZWC5 Fatty acid/phospholipid synthesis protein PlsX n=3
           Tax=Verrucomicrobia RepID=B1ZWC5_OPITP
          Length = 350

 Score = 47.4 bits (112), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 43/272 (15%), Positives = 78/272 (28%), Gaps = 60/272 (22%)

Query: 6   RVVITPGEPAG--IGP-DLVVQ---LAQREWPVELV-VCADATLLTNRAAMLGLPLTLRP 58
           R+ +   +  G  +GP ++V       ++   +  + +  D  +L    A +        
Sbjct: 10  RIAV---DAMGGDLGPAEVVEAVRLALRQYPGLNPITLVGDRAVLEPLLARVRRRPEQLT 66

Query: 59  YSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALIT 118
               S         L  L     +                 ++ RA +   +G+ + +++
Sbjct: 67  IHHASEVVTMDDKPLMALKRKKDS-----------------SMVRAIELVKDGQASVVVS 109

Query: 119 GPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADA--I 176
              + G +  AG      T          +  +        V     H  L D       
Sbjct: 110 CG-NTGALMAAG------TLRLRTMEGVARPALAAV-----VPRQNGHFVLIDAGANPDA 157

Query: 177 TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEID---TIIPVLNEL 233
            P  L     +  H  R   GIA PR+ +            +GTEE      I      L
Sbjct: 158 KPEHLVHNAILGSHYCRVMLGIARPRVGLM----------TIGTEEGKGNALITETNELL 207

Query: 234 RAQG--MKLNGPLPADTLFQPKYLDNADAVLA 263
           R     +   GP+    +F        D V+ 
Sbjct: 208 RRTTDLINYAGPIEGFHVFAEHV----DVVVC 235


>UniRef50_Q3ZZV6 Phosphate acyltransferase n=5 Tax=Dehalococcoides RepID=PLSX_DEHSC
          Length = 347

 Score = 47.4 bits (112), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 39/267 (14%), Positives = 70/267 (26%), Gaps = 57/267 (21%)

Query: 20  DLV---VQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLL 76
           +++   ++ AQ      L++     ++   A      L +                    
Sbjct: 16  EIIKGALKAAQEYKI-GLILLGKKEVIHVHAGHYLKKLPIEIVHCPQTVTFN-------- 66

Query: 77  PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGH 136
                     G+            +         G+  A I+      V+  A       
Sbjct: 67  --EHAVEAIKGKPQSA--------IVIGTSLVKQGKADAFISAGNTGAVLAAAFF----- 111

Query: 137 TEFFEERSQAKKVVMMLATEELRVALATT--HLP--LRDIADA--ITPALLHEVIAILHH 190
                +    ++  +         A+ TT  H+P  L D        P  L E   + + 
Sbjct: 112 --ILGKIEGVERPAL--------GAIITTRPHIPSLLIDAGANAECRPNHLDEFAHLGNI 161

Query: 191 DLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPA-DTL 249
             +   G+  PRI +  LN   GE    GT      +     L+   +   G +   D  
Sbjct: 162 YAKQVLGLENPRIGL--LN--NGEEEAKGT---KLTLETYQLLKKSKLNFIGNIEGHDIS 214

Query: 250 FQPKYLDNADAVLAMYHDQGLPVLKYQ 276
                +   D         G  VLK  
Sbjct: 215 LNKADVIVTDGFT------GNIVLKTL 235


>UniRef50_C8WW98 Fatty acid/phospholipid synthesis protein PlsX n=2
           Tax=Alicyclobacillus acidocaldarius RepID=C8WW98_ALIAD
          Length = 344

 Score = 46.2 bits (109), Expect = 0.002,   Method: Composition-based stats.
 Identities = 38/252 (15%), Positives = 69/252 (27%), Gaps = 53/252 (21%)

Query: 19  PDLVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPV 78
            + + Q A +    + +V  D                +R                 ++  
Sbjct: 19  MEALCQAATQYTDTKFIVIGD-------------EARIRELGGARLPDNVEVRHTDVVIA 65

Query: 79  ALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTE 138
               PV A +    +      +L  A     N E   +++   + G I  AG      T 
Sbjct: 66  GDEEPVRAVRRKPNS------SLVMAATLVANKEADVMVSAG-NTGAIMAAG------TL 112

Query: 139 FFEERSQAKKVVMMLATEEL--RVALATTHLPLRDIADAI--TPALLHEVIAILHHDLRT 194
                   ++  +         R  L      L D    +  +   L     +    +R 
Sbjct: 113 IIGRLPGVERPALAPILPTFDGRGVL------LLDAGATMDASAENLLSYAYMADAYVRH 166

Query: 195 KFGIAEPRILVCGLNPHAGEGGHMGTEEID---TIIPVLNELRAQGMKLNGPLPADTLFQ 251
              I +PRI +  LN        +GTE+      +      L    +   G + A    +
Sbjct: 167 VLDIEKPRIAL--LN--------VGTEDSKGNAVVKQAFALLSQSPLNFIGNIEA----R 212

Query: 252 PKYLDNADAVLA 263
                 AD V+ 
Sbjct: 213 EMMAGCADVVVC 224


>UniRef50_Q2RJX9 Phosphate acyltransferase n=3 Tax=Clostridia RepID=PLSX_MOOTA
          Length = 339

 Score = 46.2 bits (109), Expect = 0.002,   Method: Composition-based stats.
 Identities = 34/249 (13%), Positives = 75/249 (30%), Gaps = 42/249 (16%)

Query: 20  DLV--VQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLP 77
           ++V     A  E   E+++  D   L    A+L     +  Y  +            ++ 
Sbjct: 16  EIVRGAVAAAGEGSAEIILVGDQRRLEEELALLHPSGRIEIYHTDQ-----------VIT 64

Query: 78  VALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHT 137
           +  +  +   +    +       +  A      G   A+++       +  A +      
Sbjct: 65  MDEQPALGLRRKREAS-------IVVATRLVKEGRAEAVVSAGSTGTQMAAALL------ 111

Query: 138 EFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TPALLHEVIAILHHDLRTK 195
                  + ++  +      L+         L D+   +   P  L+E   + +      
Sbjct: 112 -ILGRSGKIQRPAIATLIPTLKGPKL-----LLDVGANVDCRPEHLYEFALMGNLYAARV 165

Query: 196 FGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPA-DTLFQPKY 254
            GI  PR+ +  +    G     G E+    +   N LR   +   G + A + LF    
Sbjct: 166 MGIPNPRVGLLNI----GTEACKGNEQ---TLGAYNLLRGAPLNFIGNVEAREILFGETD 218

Query: 255 LDNADAVLA 263
           +   D  + 
Sbjct: 219 VIVCDGFVG 227


>UniRef50_Q1MS07 Phosphate acyltransferase n=6 Tax=Desulfovibrionaceae
           RepID=PLSX_LAWIP
          Length = 347

 Score = 46.2 bits (109), Expect = 0.002,   Method: Composition-based stats.
 Identities = 33/275 (12%), Positives = 77/275 (28%), Gaps = 52/275 (18%)

Query: 1   MVKTQRVVITP----GEPAGIGPDLVV----QLAQREWPVELVVCADATLLTNRAAMLGL 52
           M+ +  + I      G+    GP +VV    +   +    ++++  +   + ++ A+L +
Sbjct: 1   MLNSHSITIAIDAMGGDY---GPSVVVPGAVKA-AQITGAKIILVGNTPEIEDQLALLQV 56

Query: 53  PLTLRPYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGE 112
             T       S           +L     +                 ++  AC     G 
Sbjct: 57  KNTKIEIVHASDVANMDEKPSDILRRKKNS-----------------SIQIACRLVKEGL 99

Query: 113 FAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDI 172
              +++       +                 +  ++  +       +  L      L D+
Sbjct: 100 ANGIVSAGHSGASVACGMF-------IIGRITGVERPALASILPTEKNPLI-----LLDV 147

Query: 173 ADAI--TPALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVL 230
              +   P  L +   + H        I  PR+ +  +    GE    G      +    
Sbjct: 148 GATVDCKPYHLFQFGLMGHTFACDLLNIQSPRVGILSI----GEEEGKGN---TQVKEAY 200

Query: 231 NELR-AQGMKLNGPLPADTLFQPK-YLDNADAVLA 263
             L+ A+ +   G +    LF     +   D  + 
Sbjct: 201 ELLKMAKDINFTGNVEGRDLFTGNVDVTICDGFVG 235


>UniRef50_C7IPB4 Fatty acid/phospholipid synthesis protein PlsX (Fragment) n=2
           Tax=Thermoanaerobacter RepID=C7IPB4_THEET
          Length = 508

 Score = 45.5 bits (107), Expect = 0.003,   Method: Composition-based stats.
 Identities = 30/253 (11%), Positives = 71/253 (28%), Gaps = 52/253 (20%)

Query: 20  DLV---VQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLL 76
           +++   ++  +    +E+V+     +L       GL    +       ++      + + 
Sbjct: 192 EIIKGSLEALKHFHDIEIVLIGKEEVLR------GLQGKEKRLKLVYASEVIENDEVPVT 245

Query: 77  PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGH 136
            V  +                  ++    +     E  A ++   + G +    +   G 
Sbjct: 246 AVRKKKD---------------SSMIVGLELLKKEEVDAFLSAG-NTGALMAGALLTLG- 288

Query: 137 TEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA--LLHEVIAILHHDLRT 194
                      +  +      L  A       L D           L +  A+ H   + 
Sbjct: 289 -----RIKGIDRPALAPILPTLNGATV-----LLDAGSNTNCDAQNLVQFAAMGHVYAQK 338

Query: 195 KFGIAEPRILVCGLNPHAGEGGHMGTEEI---DTIIPVLNELRAQGMKLNGPLPA-DTLF 250
            FGI  PR+ +           ++G EE    + +     EL+   +   G +   D  +
Sbjct: 339 MFGIERPRVGLF----------NIGVEEEKGNEVVKKAFEELKKSKLNFIGNVEGRDIPY 388

Query: 251 QPKYLDNADAVLA 263
               +   D  + 
Sbjct: 389 GVCEVVVCDGFVG 401


>UniRef50_D1B5P2 Fatty acid/phospholipid synthesis protein PlsX n=4
           Tax=Synergistaceae RepID=D1B5P2_THEAS
          Length = 334

 Score = 45.1 bits (106), Expect = 0.003,   Method: Composition-based stats.
 Identities = 33/221 (14%), Positives = 75/221 (33%), Gaps = 38/221 (17%)

Query: 25  LAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRAPV 84
             + +  + +++  DA  +            LR  + +  A+        ++ +     V
Sbjct: 24  ACEADPNLNVILVGDARRIEEH---------LRDAASSVRARIGVVHADQVVTMDDAPSV 74

Query: 85  TAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERS 144
           +  +    +       L  A +   +GE +A+++   + G I   GI   G         
Sbjct: 75  SIRKKRNSS-------LRVAMEMVRSGEASAVVSAG-NTGAIVAGGILVLG------RIP 120

Query: 145 QAKKVVMMLATEELRVALATTHLPLR-DIADAI--TPALLHEVIAILHHDLRTKFGIAEP 201
              +  +      + +A  ++ + L  D+   +   P  L +   +    +R+  G++EP
Sbjct: 121 GIDRPGL-----GVPIATLSSRVSLLIDVGATVRCKPINLAQFALMGSIYMRSLVGVSEP 175

Query: 202 RILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
            + +       GE    G E    I      L+A  +   G
Sbjct: 176 SVALLS----NGEEEIKGDE--TVIQ-AREILKASSLNFVG 209


>UniRef50_Q3AC51 Phosphate acyltransferase n=1 Tax=Carboxydothermus hydrogenoformans
           Z-2901 RepID=PLSX_CARHZ
          Length = 330

 Score = 44.3 bits (104), Expect = 0.006,   Method: Composition-based stats.
 Identities = 37/259 (14%), Positives = 74/259 (28%), Gaps = 32/259 (12%)

Query: 21  LVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVAL 80
           LVV     ++    +V      +      + L             + ++ G + ++    
Sbjct: 2   LVVDAMGGDYAPREIVLGVQDFVEETGEKIVLVGRENEIKKELTKKGKSLGYIEIINADE 61

Query: 81  RAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFF 140
              +   +  V        ++ +       G      +      V+  A +         
Sbjct: 62  VVTME-EKPTVAIKK-KESSVWKGLQLVREGVAQGFFSAGNTGAVMASAVLC-------L 112

Query: 141 EERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TPALLHEVIAILHHDLRTKFGI 198
            + +   +  ++     L     T    L D    +   P  L +   +    L+T + I
Sbjct: 113 GKINGIDRPAIITPLPTL-----TGQTFLIDAGANVDVKPENLFQFAVMAQVYLKTAYQI 167

Query: 199 AEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNA 258
             PR+ +       GE    G    D I      L+ +     G +    +F       A
Sbjct: 168 KNPRVALLS----NGEEEGKGN---DLIKKTFPILKEKISGFIGNIEGKDIF----RGVA 216

Query: 259 DAVLAMYHD--QGLPVLKY 275
           D ++A   D   G  VLK 
Sbjct: 217 DIIVA---DGFVGNIVLKT 232


>UniRef50_Q1IJ05 Phosphate acyltransferase n=10 Tax=Bacteria RepID=PLSX_ACIBL
          Length = 359

 Score = 44.3 bits (104), Expect = 0.006,   Method: Composition-based stats.
 Identities = 30/256 (11%), Positives = 63/256 (24%), Gaps = 52/256 (20%)

Query: 19  PDL--VVQLAQREWPVELVVCADATLLTN--RAAMLGLPLTLRPYSPNSPAQPQTAGTLT 74
           P++   +Q  +  + V +++     +L     A      L +     +          L 
Sbjct: 18  PEIEGALQAIRH-FDVRVILVGKQDVLREHLGAHAHPGRLPIEIVHASEVISMHDKAALA 76

Query: 75  LLPVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFT 134
           +                        ++         G+  A +T       +  A     
Sbjct: 77  VRSKRDS------------------SMRVGLRLVREGKADAFVTAGNTGAAMATAK---- 114

Query: 135 GHTEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TPALLHEVIAILHHDL 192
                        +  +       +   A     L D+   +   P  L +   +     
Sbjct: 115 ---MVLGALPGVDRPALAAVFPTEKRTAA----ILLDVGANVDCKPQNLQQFAIMGEVYF 167

Query: 193 RTKFG-----IAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPAD 247
           RT F         PR+ +  +    GE    G E           ++   +   G +   
Sbjct: 168 RTVFAGKSPHARSPRVGILSI----GEEETKGNE---LTREAYKLVKTLPLNFVGNVEGR 220

Query: 248 TLFQPKYLDNADAVLA 263
            LF      N D ++ 
Sbjct: 221 DLF----NGNVDVLVC 232


>UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms
           RepID=LEU3_ARCFU
          Length = 326

 Score = 44.3 bits (104), Expect = 0.007,   Method: Composition-based stats.
 Identities = 9/33 (27%), Positives = 17/33 (51%), Gaps = 3/33 (9%)

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
             HG A ++AG+G A+  +    +  A  M+ +
Sbjct: 252 PVHGAAFDIAGKGIANPTAM---ILTACMMLRH 281


>UniRef50_B0K1W5 Phosphate acyltransferase n=10 Tax=Thermoanaerobacterales
           RepID=PLSX_THEPX
          Length = 332

 Score = 43.9 bits (103), Expect = 0.008,   Method: Composition-based stats.
 Identities = 30/253 (11%), Positives = 71/253 (28%), Gaps = 52/253 (20%)

Query: 20  DLV---VQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLL 76
           +++   ++  +    +E+V+     +L       GL    +       ++      + + 
Sbjct: 16  EIIKGSLEALKHFHDIEIVLIGKEEVLR------GLQGKEKRLKLVYASEVIENDEVPVT 69

Query: 77  PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGH 136
            V  +                  ++    +     E  A ++   + G +    +   G 
Sbjct: 70  AVRKKKD---------------SSMIVGLELLKKEEVDAFLSAG-NTGALMAGALLTLG- 112

Query: 137 TEFFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPA--LLHEVIAILHHDLRT 194
                      +  +      L  A       L D           L +  A+ H   + 
Sbjct: 113 -----RIKGIDRPALAPILPTLNGATV-----LLDAGSNTNCDAQNLVQFAAMGHVYAQK 162

Query: 195 KFGIAEPRILVCGLNPHAGEGGHMGTEEI---DTIIPVLNELRAQGMKLNGPL-PADTLF 250
            FGI  PR+ +           ++G EE    + +     EL+   +   G +   D  +
Sbjct: 163 MFGIERPRVGLF----------NIGVEEEKGNEVVKKAFEELKKSKLNFIGNVEGRDIPY 212

Query: 251 QPKYLDNADAVLA 263
               +   D  + 
Sbjct: 213 GVCEVVVCDGFVG 225


>UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2
           Tax=environmental samples RepID=B3TCK6_9ARCH
          Length = 339

 Score = 43.2 bits (101), Expect = 0.012,   Method: Composition-based stats.
 Identities = 9/29 (31%), Positives = 17/29 (58%)

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIK 323
             HG A ++AG+  A+  SFI ++ + + 
Sbjct: 259 PVHGAAFDIAGKQIANPTSFILSIKMMLD 287


>UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37
           RepID=A1SWV5_PSYIN
          Length = 368

 Score = 43.2 bits (101), Expect = 0.013,   Method: Composition-based stats.
 Identities = 11/31 (35%), Positives = 20/31 (64%)

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMI 325
             HG+A ++AG+G A+  S I ++ L ++M 
Sbjct: 283 PSHGSAPDIAGKGIANPYSMIGSVALMLEMS 313


>UniRef50_A0LI09 Phosphate acyltransferase n=1 Tax=Syntrophobacter fumaroxidans MPOB
           RepID=PLSX_SYNFM
          Length = 353

 Score = 42.8 bits (100), Expect = 0.017,   Method: Composition-based stats.
 Identities = 53/346 (15%), Positives = 94/346 (27%), Gaps = 93/346 (26%)

Query: 24  QLAQREW-PVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALRA 82
            L        +++V  +   L++  A  G   +L+                         
Sbjct: 21  ALLAGPQCSADILVIGNEARLSSLLAHSGDSTSLKVVHAPQV------------------ 62

Query: 83  PVTAGQLAVENGHYVVE-TLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFE 141
            +  G+          E +L  A       E  A+++      V++ A            
Sbjct: 63  -IGMGEAGPMALRRKREASLTIAMRLLAENEVDAVVSAGNSSAVVSAAR-------HLVG 114

Query: 142 ERSQAKKVVMMLATEELRVALATTHLPLRDIADA--ITPALLHEVIAILHHDLRTKFGIA 199
                ++  M +        L      L D       T   L +   + H  L+ + G+ 
Sbjct: 115 LIPGLRRPAMAVPLPTPSGKLL-----LLDAGAHAEATAIHLAQSAVLAHCYLKIEEGLN 169

Query: 200 EPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNAD 259
            PRI +  +    G     G      +      LR   ++  G +  + LF        D
Sbjct: 170 RPRIGLLNI----GHEPAKGN---RAVQRAFALLRRCSLEFTGNVEPNDLFA----GKVD 218

Query: 260 AVLAMYHD--QGLPVLKYQ-GFGRGV--------------------------------NI 284
           AV+    D   G  +LK   GF   V                                  
Sbjct: 219 AVIC---DGFVGNVLLKMYEGFSETVCRFLESLANHDGRDFSGGAGRILERFRRDYHYEF 275

Query: 285 TLGLPF--IRTSVDHGTALELAGRGKADVGSFITALNLAIKMIVNT 328
             G P   IR +V       +A  G++   +   A+ LA ++    
Sbjct: 276 VGGAPLLGIRKTV-------VAAHGRSRATAIANAIRLACRLQEAR 314


>UniRef50_B2KC86 Phosphate acyltransferase n=5 Tax=Bacteria RepID=PLSX_ELUMP
          Length = 341

 Score = 42.4 bits (99), Expect = 0.024,   Method: Composition-based stats.
 Identities = 33/221 (14%), Positives = 63/221 (28%), Gaps = 45/221 (20%)

Query: 28  REWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVA-LRAPVTA 86
           +E   E+++  D  +L  + A LGL                      ++ +    A    
Sbjct: 26  KELKCEVILVGDEKVLKEQLASLGLS---------DLKGLSVEHAPDVIDMDADPAKEVR 76

Query: 87  GQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTE-----FFE 141
            +           ++  A D    G   A ++       +  A +   G  E        
Sbjct: 77  SKKNA--------SVVVAADLVKQGRAKAFVSAGNSGATMVAALMK-MGRIEGVLRPAIG 127

Query: 142 ERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEP 201
                 K +M+L                        P  L +   +     +  FGI +P
Sbjct: 128 APLPTVKGLMLLLDAG--------------ANAECKPQHLMQFAVMGSIYTQKVFGIRKP 173

Query: 202 RILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNG 242
           ++ +  +    GE    G + +    P L+ L   G+   G
Sbjct: 174 KVGLLSI----GEEEGKGNDLVKETYPYLSNL---GINFCG 207


>UniRef50_Q2JJA1 Phosphate acyltransferase n=13 Tax=Bacteria RepID=PLSX_SYNJB
          Length = 374

 Score = 42.0 bits (98), Expect = 0.029,   Method: Composition-based stats.
 Identities = 30/247 (12%), Positives = 71/247 (28%), Gaps = 31/247 (12%)

Query: 21  LVVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLT--LLPV 78
           + V     ++  E ++     LL +R   +G+ L           +P     L   +  V
Sbjct: 3   IAVDAMGGDYAPEEIIKG--ALLAHRQLRVGIAL----VGRPDSLKPFLPQPLPAGITIV 56

Query: 79  ALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTE 138
                V   +  +        ++  +     + +  A++        +  A +       
Sbjct: 57  PAEEDVGMAEEPLMVRKKPKASINISMQQVRSNQADAVVAAGNTGAAMAAAYLN------ 110

Query: 139 FFEERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TPALLHEVIAILHHDLRTKF 196
                +   +  +      L+         L D+   +   P  L +   +     +   
Sbjct: 111 -LGRLAGIDRPAIGALLPTLKGKPVL----LLDVGANVDCRPRFLEQFARMGSLYCQCVL 165

Query: 197 GIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLD 256
           GI +PR+ +  +    GE  + G      +       +  G+   G   A+   +     
Sbjct: 166 GIEKPRVGLLNI----GEEPNKGN--DLALATHQRLAQLPGIHFAG--NAEG--RDVLTG 215

Query: 257 NADAVLA 263
             D V+ 
Sbjct: 216 EFDVVVC 222


>UniRef50_B3T0Q5 Putative fatty acid synthesis protein n=2 Tax=prokaryotic
           environmental samples RepID=B3T0Q5_9ZZZZ
          Length = 370

 Score = 42.0 bits (98), Expect = 0.031,   Method: Composition-based stats.
 Identities = 31/242 (12%), Positives = 75/242 (30%), Gaps = 40/242 (16%)

Query: 22  VVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALR 81
            + L +    V++ +  +  ++  + +   +   L+    +   Q      + L      
Sbjct: 66  ALNLLELREDVKIFLVGNKEIIEKQTSG-KIGNRLQILHADEVVQMSDPPVVVLRKKKQS 124

Query: 82  APVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFE 141
                             ++ RA D   +G   A ++   + G +              +
Sbjct: 125 ------------------SMRRAVDLVKDGVSQACVSSG-NTGALMAI------SKYVLK 159

Query: 142 ERSQAKKVVMMLATEELRVALATTHLPLRDIADAITPALLHEVIAILHHDLRTKFGIAEP 201
                 +  +M +   ++    +T++         T   L++   +     +   GI +P
Sbjct: 160 TIPTIDRPALMTSIPTMK---GSTYVLDLGANSNCTSEQLYQFALMGDVAAKEIKGIDQP 216

Query: 202 RILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQPKYLDNADAV 261
           RI +  LN   GE    G      I    N + +  +   G +  +++        AD V
Sbjct: 217 RIGL--LN--MGEEASKGN---QVIKEAANLMHSSSINFIGYIEGNSI----AEGKADVV 265

Query: 262 LA 263
           + 
Sbjct: 266 VT 267


>UniRef50_C9RQT8 Phosphate acetyltransferase n=3 Tax=Bacteria RepID=C9RQT8_FIBSS
          Length = 467

 Score = 41.6 bits (97), Expect = 0.035,   Method: Composition-based stats.
 Identities = 18/104 (17%), Positives = 34/104 (32%), Gaps = 10/104 (9%)

Query: 25  LAQREWPVELVVCADATLLTNRAAMLGLPLT--LRPYSPNSPAQPQTAGTLTLLPVALRA 82
           LA        V+      +   A  +G+ L   +    P++    +   TL  L  A   
Sbjct: 176 LAVERNIAVPVLIGKKADIEATAKSVGVKLPANIEIIEPSAELAEKYVPTLVELRKAKG- 234

Query: 83  PVTAGQLAVENGHYVV-ETLARACDGCLNGEFAALITGPVHKGV 125
                 +  E+    + + +  A      GE   L++G +H   
Sbjct: 235 ------MTPESARAALSDNVMLATMMLKFGEVDGLVSGAIHSTA 272


>UniRef50_D1C2Y6 Fatty acid/phospholipid synthesis protein PlsX n=1
           Tax=Sphaerobacter thermophilus DSM 20745
           RepID=D1C2Y6_SPHTD
          Length = 346

 Score = 41.6 bits (97), Expect = 0.038,   Method: Composition-based stats.
 Identities = 31/182 (17%), Positives = 52/182 (28%), Gaps = 22/182 (12%)

Query: 45  NRAAMLGLPLTLR-PYSPNSPAQPQTAGTLTLLPVALRAPVTAGQLAVENG--HYVVETL 101
                LG+P+ L    +          G    L V     V   +             ++
Sbjct: 33  RAVRELGIPVALVGRAAEVERLVRGLGGPFPGLTVIDAPEVVTMEDQAVAAVRRKSRASI 92

Query: 102 ARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFEERSQAKKVVMMLATEELRVA 161
             A +    G  AA ++      V+  A                  +  + +   ++   
Sbjct: 93  PVALEAVKEGRAAAFVSAGNSGAVVAGALFG-------LGRLPGIDRPAIAIPFPKI--- 142

Query: 162 LATTHLPLRDIADAIT---PALLHEVIAILHHDLRTKFGIAEPRILVCGLNPHAGEGGHM 218
            A   + L D   A+T   P  L +   +    LR   G+ EPRI +       GE    
Sbjct: 143 -AGGSVLLLDA-GAVTDPRPQHLVQYARLASAYLRHVNGVPEPRIGLLS----NGEEAIK 196

Query: 219 GT 220
           G 
Sbjct: 197 GN 198


>UniRef50_A8SMT8 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC
           33270 RepID=A8SMT8_9FIRM
          Length = 336

 Score = 41.2 bits (96), Expect = 0.050,   Method: Composition-based stats.
 Identities = 40/275 (14%), Positives = 82/275 (29%), Gaps = 43/275 (15%)

Query: 21  LVVQLAQREWPVELV---VCADATLLTN-RAAMLGLPLTLRPYSPNSPAQPQTAGTLTLL 76
           ++V L   +   E +   V   + LL +    ++G   T+   + +   +      L ++
Sbjct: 8   IIVDLLGSDKGAETIFKGVIETSKLLKDLYFVVIGPKETIEKVNISDDLK----NRLEII 63

Query: 77  PVALRAPVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGH 136
                  +   +           ++         GE   LI+       +          
Sbjct: 64  DTK-EYILNTEEPTFAVRRKKNASIVLGMKCLDKGEADGLISFGSTGAALVSGLF----- 117

Query: 137 TEFFEERSQAKKVVMMLATEELRVALATTH--LPLRDIADA--ITPALLHEVIAILHHDL 192
               +     ++         L + L T    + L DI      T  +L +   + +   
Sbjct: 118 --IAKRMENVERPA-------LTITLPTNKDKMILLDIGANTDCTTDILKQFAIMGNIYA 168

Query: 193 RTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQP 252
           +       P+I +  +     E G  GT     +    + L  + M   G + +  +F  
Sbjct: 169 KETLNKENPKIALLNI---GSENGK-GT---KILKETYSVLENENMNFVGNIESRDIF-- 219

Query: 253 KYLDNADAVLA-MYHDQGLPVLKYQGFGRGVNITL 286
               + D V+   +H  G  VLK       V   L
Sbjct: 220 --NGDVDVVVCDGFH--GNVVLKTI--EGSVKFIL 248


>UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria
           RepID=LEU3_RHIEC
          Length = 370

 Score = 41.2 bits (96), Expect = 0.056,   Method: Composition-based stats.
 Identities = 9/33 (27%), Positives = 19/33 (57%)

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIKMIVN 327
             HG+A ++AG+G A+  + I +  + ++   N
Sbjct: 287 PVHGSAPDIAGKGIANPIAMIASFAMCLRYSFN 319


>UniRef50_Q4KGI2 Putative uncharacterized protein n=1 Tax=Pseudomonas fluorescens
           Pf-5 RepID=Q4KGI2_PSEF5
          Length = 72

 Score = 40.8 bits (95), Expect = 0.060,   Method: Composition-based stats.
 Identities = 10/28 (35%), Positives = 15/28 (53%)

Query: 225 TIIPVLNELRAQGMKLNGPLPADTLFQP 252
            I P +   +A G+  +GP P DT+F  
Sbjct: 2   IIGPAVKAAQALGIATDGPYPGDTIFLK 29


>UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms
           RepID=LEU3_BRUA2
          Length = 370

 Score = 40.8 bits (95), Expect = 0.065,   Method: Composition-based stats.
 Identities = 9/29 (31%), Positives = 19/29 (65%)

Query: 295 VDHGTALELAGRGKADVGSFITALNLAIK 323
             HG+A ++AG+G A+  + I +L + ++
Sbjct: 287 PVHGSAPDIAGKGIANPIAMIASLAMCLR 315


>UniRef50_C9RCW3 Fatty acid/phospholipid synthesis protein PlsX n=1 Tax=Ammonifex
           degensii KC4 RepID=C9RCW3_AMMDK
          Length = 337

 Score = 40.8 bits (95), Expect = 0.066,   Method: Composition-based stats.
 Identities = 42/252 (16%), Positives = 78/252 (30%), Gaps = 41/252 (16%)

Query: 21  LVVQLAQREWPVELVVCADATLLTNRAAM----LGLPLTLRPYSPNSPAQPQTAGTLTLL 76
           + +     ++  E  V      + +   +    +G    LRP  P    +          
Sbjct: 3   VALDAMGGDYAPEATVEGAVAAVKSFEEIEVYLVGPEERLRPLIPADLGEKIKL------ 56

Query: 77  PVALRAPVTAGQLAVENGHYV-VETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTG 135
            V+    +  G+  V+        +L R  +    G+  A ++   + G +  A   + G
Sbjct: 57  -VSASEVIEMGESPVQAVRRKRASSLVRTVELLKEGQVDAAVSAG-NTGALLAAASLYLG 114

Query: 136 HTEFFEERSQAKKVVMM--LATEELRVALATTHLPLRDIADA--ITPALLHEVIAILHHD 191
                      ++  +M  L     R  L        D+     + P  L +   +    
Sbjct: 115 ------RIPGVERPALMAQLPNPRGRTVLL-------DVGANVDVKPHHLAQFAVMGSIY 161

Query: 192 LRTKFGIAEPRILVCGLNPHAGEGGHMGTEEIDTIIPVLNELRAQGMKLNGPLPADTLFQ 251
            R   GIA PR+ +  +    GE    G E      P+   LR   +   G +    +F 
Sbjct: 162 ARDMLGIASPRVGLLSI----GEEETKGNELTLATFPL---LRKLPLNFIGNVEGRDVF- 213

Query: 252 PKYLDNADAVLA 263
                 AD V+ 
Sbjct: 214 ---NGRADVVVC 222


>UniRef50_C0ZFP6 Phosphate acyltransferase n=2 Tax=Firmicutes RepID=PLSX_BREBN
          Length = 335

 Score = 40.8 bits (95), Expect = 0.069,   Method: Composition-based stats.
 Identities = 33/247 (13%), Positives = 71/247 (28%), Gaps = 49/247 (19%)

Query: 22  VVQLAQREWPVELVVCADATLLTNRAAMLGLPLTLRPYSPNSPAQPQTAGTLTLLPVALR 81
            +   +    + +V+  D   + N            P    +  +   A  + L      
Sbjct: 21  ALAAIKENPAITVVLVGDEQAIRNH----------LPQDIPANIEIVPAAEVILPDDEPV 70

Query: 82  APVTAGQLAVENGHYVVETLARACDGCLNGEFAALITGPVHKGVINDAGIPFTGHTEFFE 141
             V   + +         +L  A +     +  A+I+   + G +  AG+ + G      
Sbjct: 71  RAVRRKKNS---------SLVVAVEMAREKKVDAMISAG-NTGALMTAGLLYAG------ 114

Query: 142 ERSQAKKVVMMLATEELRVALATTHLPLRDIADAI--TPALLHEVIAILHHDLRTKFGIA 199
                ++  +       +    T  L   D+   +   P  L +   +         G  
Sbjct: 115 RMDGIERPALCAYIPNSK-GRVTLTL---DVGANMDAKPHQLVQYAVMGSLYAEKVLGFE 170

Query: 200 EPRILVCGLNPHAGEGGHMGTEEI---DTIIPVLNELRAQGMKLNGPLPADTLFQPKYLD 256
            P + +  LN        +GTEE    +    V   L+   +   G + A    +     
Sbjct: 171 RPTVGL--LN--------VGTEEGKGNELTKAVFPLLQEADLNFVGNVEA----RDVMQG 216

Query: 257 NADAVLA 263
             D ++ 
Sbjct: 217 ACDVLVC 223


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.314    0.172    0.558 

Lambda     K      H
   0.267   0.0524    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,380,317,198
Number of Sequences: 3077464
Number of extensions: 126982016
Number of successful extensions: 262916
Number of sequences better than 1.0e-01: 193
Number of HSP's better than  0.1 without gapping: 471
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 261224
Number of HSP's gapped (non-prelim): 550
length of query: 329
length of database: 1,040,396,356
effective HSP length: 129
effective length of query: 200
effective length of database: 643,403,500
effective search space: 128680700000
effective search space used: 128680700000
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.1 bits)
S2: 94 (40.5 bits)
