BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (422 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_B5FFN4 Bifunctional protein FolC n=7 Tax=Vibrionaceae R... 424 e-117 UniRef50_P43775 Folylpolyglutamate synthase n=258 Tax=Gammaprote... 415 e-114 UniRef50_Q492H5 Folylpolyglutamate synthase n=3 Tax=Enterobacter... 412 e-113 UniRef50_Q12P54 FolC bifunctional protein n=10 Tax=Shewanella Re... 403 e-111 UniRef50_C6AMR7 FolC bifunctional protein n=3 Tax=Pasteurellacea... 397 e-109 UniRef50_Q8K9X3 Dihydrofolate synthase n=1 Tax=Buchnera aphidico... 389 e-106 UniRef50_B0UU80 FolC bifunctional protein n=14 Tax=Pasteurellace... 384 e-105 UniRef50_Q5QWH7 Folylpolyglutamate synthase n=2 Tax=Idiomarina R... 366 e-100 UniRef50_Q89AT2 Dihydrofolate synthase n=4 Tax=Buchnera aphidico... 365 2e-99 UniRef50_A6FEP3 Dihydrofolate synthase / folylpolyglutamate synt... 360 6e-98 UniRef50_A1SW71 FolC bifunctional protein n=2 Tax=Psychromonas R... 360 7e-98 UniRef50_A6VWY8 FolC bifunctional protein n=2 Tax=Marinomonas Re... 349 1e-94 UniRef50_Q0AGX2 FolC bifunctional protein n=1 Tax=Nitrosomonas e... 347 5e-94 UniRef50_B6J6W5 Folylpolyglutamate synthase n=6 Tax=Coxiella bur... 346 9e-94 UniRef50_Q8D2P3 FolC protein n=1 Tax=Wigglesworthia glossinidia ... 345 2e-93 UniRef50_Q88LD8 Folylpolyglutamate synthetase n=23 Tax=Pseudomon... 344 3e-93 UniRef50_A2SKX9 Cytoplasmic peptidoglycan synthetase, C-terminal... 340 6e-92 UniRef50_Q15VG0 FolC bifunctional protein n=1 Tax=Pseudoalteromo... 338 2e-91 UniRef50_Q3JCB5 Folylpolyglutamate synthetase n=3 Tax=Gammaprote... 338 2e-91 UniRef50_Q3IF42 Bifunctional: folylpolyglutamate synthase; dihyd... 337 4e-91 UniRef50_Q604P6 Folylpolyglutamate synthase/dihydrofolate syntha... 337 4e-91 UniRef50_C6P114 FolC bifunctional protein n=1 Tax=Sideroxydans l... 334 3e-90 UniRef50_A8PMD7 FolC bifunctional protein n=1 Tax=Rickettsiella ... 334 3e-90 UniRef50_Q1N6P7 Folylpolyglutamate synthetase n=1 Tax=Bermanella... 334 4e-90 UniRef50_A6GNX1 FolC bifunctional protein n=1 Tax=Limnobacter sp... 331 3e-89 UniRef50_C6MBR5 FolC bifunctional protein n=1 Tax=Nitrosomonas s... 327 6e-88 UniRef50_Q2BMN3 Folylpolyglutamate synthase n=1 Tax=Neptuniibact... 326 1e-87 UniRef50_B4RUR1 Bifunctional folylpolyglutamate synthase/dihydro... 320 5e-86 UniRef50_B5JSE1 FolC bifunctional protein n=1 Tax=gamma proteoba... 318 2e-85 UniRef50_Q47XK6 FolC bifunctional protein n=1 Tax=Colwellia psyc... 316 1e-84 UniRef50_Q6FEE4 Bifunctional protein n=18 Tax=Acinetobacter RepI... 311 3e-83 UniRef50_UPI0000E0E8A2 FolC bifunctional protein n=1 Tax=Rhodoba... 310 9e-83 UniRef50_B8GQE7 FolC bifunctional protein n=1 Tax=Thioalkalivibr... 308 4e-82 UniRef50_A7C245 Folylpolyglutamate synthase/dihydrofolate syntha... 306 1e-81 UniRef50_C6WVE3 FolC bifunctional protein n=1 Tax=Methylotenera ... 306 1e-81 UniRef50_C6N083 FolC bifunctional protein n=2 Tax=Legionella Rep... 305 2e-81 UniRef50_C1D9J6 FolC n=26 Tax=Neisseriaceae RepID=C1D9J6_LARHH 303 7e-81 UniRef50_Q2NZP7 Folylpolyglutamate synthase n=19 Tax=Xanthomonad... 302 2e-80 UniRef50_C5SCQ4 FolC bifunctional protein n=1 Tax=Allochromatium... 301 3e-80 UniRef50_B3PFP2 Folylpolyglutamate synthetase n=1 Tax=Cellvibrio... 300 8e-80 UniRef50_A5IBI5 FolC bifunctional protein n=4 Tax=Legionella pne... 299 1e-79 UniRef50_Q31HH1 FolC bifunctional folylpolyglutamate synthase/di... 296 1e-78 UniRef50_A1U0X0 FolC bifunctional protein n=3 Tax=Marinobacter R... 295 2e-78 UniRef50_Q1QDK0 FolC bifunctional protein n=4 Tax=Moraxellaceae ... 292 2e-77 UniRef50_A1UZ44 FolC bifunctional protein n=107 Tax=cellular org... 291 3e-77 UniRef50_Q0A999 FolC bifunctional protein n=1 Tax=Alkalilimnicol... 288 3e-76 UniRef50_Q1QY39 FolC bifunctional protein n=1 Tax=Chromohalobact... 288 3e-76 UniRef50_Q2SJC8 Folylpolyglutamate synthase n=1 Tax=Hahella chej... 288 3e-76 UniRef50_A0YB05 FolC bifunctional protein n=1 Tax=marine gamma p... 288 3e-76 UniRef50_B8KYD9 Folylpolyglutamate synthase n=1 Tax=gamma proteo... 284 3e-75 UniRef50_C7RCA3 FolC bifunctional protein n=1 Tax=Kangiella kore... 282 1e-74 UniRef50_B7RU63 FolC bifunctional protein n=1 Tax=marine gamma p... 282 1e-74 UniRef50_Q21IZ3 FolC bifunctional protein n=1 Tax=Saccharophagus... 278 4e-73 UniRef50_D2UBJ9 Probable folc bifunctional protein [includes fol... 275 2e-72 UniRef50_A4BRV9 Folylpolyglutamate synthase/dihydrofolate syntha... 275 3e-72 UniRef50_A4A847 Folylpolyglutamate synthase/dihydrofolate syntha... 274 5e-72 UniRef50_A1WY03 FolC bifunctional protein n=1 Tax=Halorhodospira... 270 9e-71 UniRef50_UPI0000E88026 folylpolyglutamate synthetase n=1 Tax=Met... 267 7e-70 UniRef50_B9ZQU2 FolC bifunctional protein n=1 Tax=Thioalkalivibr... 259 2e-67 UniRef50_B1FP43 FolC bifunctional protein n=1 Tax=Burkholderia a... 258 3e-67 UniRef50_A4BHC7 FolC bifunctional folylpolyglutamate synthase/di... 257 5e-67 UniRef50_Q1YT82 Folylpolyglutamate synthetase n=2 Tax=Proteobact... 257 7e-67 UniRef50_D0KZW9 FolC bifunctional protein n=1 Tax=Halothiobacill... 253 9e-66 UniRef50_A5EVX7 Folylpolyglutamate synthase n=2 Tax=Cardiobacter... 247 6e-64 UniRef50_A1AXP8 FolC bifunctional protein n=5 Tax=Bacteria RepID... 245 3e-63 UniRef50_C5BL57 FolC bifunctional protein n=1 Tax=Teredinibacter... 243 1e-62 UniRef50_Q12D50 FolC bifunctional protein n=4 Tax=Proteobacteria... 234 4e-60 UniRef50_Q0VPJ2 Folylpolyglutamate synthase / dihydrofolate synt... 226 1e-57 UniRef50_B5EK15 FolC bifunctional protein n=2 Tax=Acidithiobacil... 224 4e-57 UniRef50_B6BU94 Folylpolyglutamate synthase/dihydrofolate syntha... 223 1e-56 UniRef50_A0Z5L0 Folylpolyglutamate synthase/dihydrofolate syntha... 220 6e-56 UniRef50_C5CEI6 FolC bifunctional protein n=1 Tax=Kosmotoga olea... 216 1e-54 UniRef50_B0VF02 FolC bifunctional protein n=1 Tax=Candidatus Clo... 203 8e-51 UniRef50_Q28WD6 FolC bifunctional protein n=2 Tax=Rhodobacterale... 200 7e-50 UniRef50_B9L391 Folylpolyglutamate synthase (Folylpoly-gamma-glu... 200 7e-50 UniRef50_C6NYQ6 Dihydrofolate synthase / Folylpolyglutamate synt... 200 8e-50 UniRef50_B5YJI6 Folylpolyglutamate synthase n=1 Tax=Thermodesulf... 199 2e-49 UniRef50_A0LIV6 FolC bifunctional protein n=1 Tax=Syntrophobacte... 195 3e-48 UniRef50_A4XL37 FolC bifunctional protein n=5 Tax=Clostridia Rep... 192 1e-47 UniRef50_C0GS76 FolC bifunctional protein n=1 Tax=Desulfonatrono... 192 3e-47 UniRef50_Q3A6L0 Folylpolyglutamate synthetase; dihydrofolate syn... 191 4e-47 UniRef50_Q1D8V1 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 190 8e-47 UniRef50_B0K4K8 FolC bifunctional protein n=15 Tax=Clostridia Re... 190 1e-46 UniRef50_C1A3X2 Folylpolyglutamate synthase n=1 Tax=Gemmatimonas... 189 2e-46 UniRef50_B4CZE0 FolC bifunctional protein n=1 Tax=Chthoniobacter... 188 3e-46 UniRef50_Q1JY09 FolC bifunctional protein n=1 Tax=Desulfuromonas... 188 3e-46 UniRef50_C7N4J3 Folylpolyglutamate synthase/dihydrofolate syntha... 188 3e-46 UniRef50_C7MLS9 Folylpolyglutamate synthase/dihydrofolate syntha... 188 3e-46 UniRef50_A5FMS8 FolC bifunctional protein n=21 Tax=Bacteroidetes... 187 5e-46 UniRef50_D0MEF9 FolC bifunctional protein n=1 Tax=Rhodothermus m... 187 6e-46 UniRef50_D0WG21 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 187 8e-46 UniRef50_C7JGW9 Bifunctional protein FolC n=8 Tax=Acetobacter pa... 187 9e-46 UniRef50_B8CY17 Folylpolyglutamate synthase n=1 Tax=Halothermoth... 186 1e-45 UniRef50_C6Y3V5 FolC bifunctional protein n=4 Tax=Sphingobacteri... 186 1e-45 UniRef50_B5EAK4 FolC bifunctional protein n=6 Tax=Geobacter RepI... 186 1e-45 UniRef50_D0GKP2 Tetrahydrofolate synthase n=1 Tax=Leptotrichia g... 186 2e-45 UniRef50_Q1GD59 FolC bifunctional protein n=6 Tax=Alphaproteobac... 185 2e-45 UniRef50_D1PA28 Tetrahydrofolate synthase n=1 Tax=Prevotella cop... 185 3e-45 UniRef50_B8FMP6 FolC bifunctional protein n=1 Tax=Desulfatibacil... 185 3e-45 UniRef50_B9XQF6 FolC bifunctional protein n=1 Tax=bacterium Elli... 185 3e-45 UniRef50_B8DZV7 FolC bifunctional protein n=1 Tax=Dictyoglomus t... 184 4e-45 UniRef50_B5ZCR5 FolC bifunctional protein n=2 Tax=Gluconacetobac... 184 5e-45 UniRef50_Q5CB75 Folylpolyglutamate synthase/dihydrofolate syntha... 184 7e-45 UniRef50_Q01UR3 FolC bifunctional protein n=1 Tax=Candidatus Sol... 184 8e-45 UniRef50_A5TUM3 Tetrahydrofolate synthase n=15 Tax=Fusobacterium... 183 9e-45 UniRef50_Q2JLQ4 Folylpolyglutamate synthase n=2 Tax=Synechococcu... 183 1e-44 UniRef50_A8SN77 Putative uncharacterized protein n=1 Tax=Parvimo... 182 2e-44 UniRef50_D2QCN6 FolC bifunctional protein n=1 Tax=Spirosoma ling... 181 4e-44 UniRef50_A6TN35 FolC bifunctional protein n=2 Tax=Alkaliphilus R... 181 5e-44 UniRef50_B9KIR3 Folylpolyglutamate synthase (FolC) n=5 Tax=Ricke... 181 6e-44 UniRef50_Q7NLP7 Folylpolyglutamate synthase n=1 Tax=Gloeobacter ... 181 6e-44 UniRef50_B9MJT0 FolC bifunctional protein n=2 Tax=Clostridiales ... 180 7e-44 UniRef50_A9KNK7 FolC bifunctional protein n=1 Tax=Clostridium ph... 180 8e-44 UniRef50_A6LA17 Folylpolyglutamate synthase n=8 Tax=Bacteroidale... 179 1e-43 UniRef50_A8ZTL3 FolC bifunctional protein n=1 Tax=Desulfococcus ... 179 2e-43 UniRef50_C9M7C2 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 179 2e-43 UniRef50_C7H9L3 Tetrahydrofolate synthase n=2 Tax=Faecalibacteri... 178 3e-43 UniRef50_C0QUQ6 Folylpolyglutamate synthetase n=2 Tax=Aquificale... 178 3e-43 UniRef50_Q31PP5 FolC bifunctional protein n=2 Tax=Synechococcus ... 178 4e-43 UniRef50_B0S2B5 Folylpolyglutamate synthase n=2 Tax=Finegoldia m... 177 5e-43 UniRef50_Q5V5Y3 Dihydropteroate synthase n=1 Tax=Haloarcula mari... 177 5e-43 UniRef50_B2J1B6 FolC bifunctional protein n=25 Tax=Bacteria RepI... 177 5e-43 UniRef50_D1AM93 FolC bifunctional protein n=1 Tax=Sebaldella ter... 177 6e-43 UniRef50_Q3B220 Folylpolyglutamate synthetase n=8 Tax=Chlorobiac... 177 7e-43 UniRef50_D2RP25 FolC bifunctional protein n=2 Tax=Acidaminococcu... 177 7e-43 UniRef50_A7VV81 Putative uncharacterized protein n=1 Tax=Clostri... 177 8e-43 UniRef50_Q0BQJ2 Folylpolyglutamate synthase n=2 Tax=Acetobactera... 177 8e-43 UniRef50_A3VQ98 FolC bifunctional protein n=1 Tax=Parvularcula b... 176 1e-42 UniRef50_B6YQL7 Folylpolyglutamate synthase n=7 Tax=Bacteroidale... 176 1e-42 UniRef50_B0T696 FolC bifunctional protein n=2 Tax=Alphaproteobac... 176 1e-42 UniRef50_B1CAR2 Putative uncharacterized protein n=1 Tax=Anaerof... 176 2e-42 UniRef50_C0ZAJ3 Folylpolyglutamate synthase n=1 Tax=Brevibacillu... 176 2e-42 UniRef50_C6WZI5 Dihydrofolate synthase n=2 Tax=Flavobacteriaceae... 176 2e-42 UniRef50_B2V618 FolC bifunctional protein n=3 Tax=Sulfurihydroge... 175 2e-42 UniRef50_C3J886 Folylpolyglutamate synthase n=15 Tax=Bacteria Re... 175 3e-42 UniRef50_B3CMD5 Folylpolyglutamate synthase n=2 Tax=Wolbachia en... 175 3e-42 UniRef50_A8F8Q4 FolC bifunctional protein n=1 Tax=Thermotoga let... 175 3e-42 UniRef50_B3QVA8 FolC bifunctional protein n=1 Tax=Chloroherpeton... 175 3e-42 UniRef50_C9RB31 FolC bifunctional protein n=1 Tax=Ammonifex dege... 175 4e-42 UniRef50_C0QB10 FolC n=1 Tax=Desulfobacterium autotrophicum HRM2... 174 4e-42 UniRef50_B3ELQ9 FolC bifunctional protein n=2 Tax=Chlorobiaceae ... 174 4e-42 UniRef50_B1ZVD5 FolC bifunctional protein n=4 Tax=Verrucomicrobi... 174 5e-42 UniRef50_Q11UV3 Tetrahydrofolylpolyglutamate synthase (Folylpoly... 174 5e-42 UniRef50_Q0AWF7 Putative uncharacterized protein n=1 Tax=Syntrop... 174 6e-42 UniRef50_B8FVG3 FolC bifunctional protein n=2 Tax=Desulfitobacte... 174 7e-42 UniRef50_Q6MAP9 Putative folylpolyglutamate synthase n=1 Tax=Can... 174 7e-42 UniRef50_D2LDB9 FolC bifunctional protein n=1 Tax=Rhodomicrobium... 174 7e-42 UniRef50_B0MYL2 Putative uncharacterized protein n=1 Tax=Alistip... 174 7e-42 UniRef50_D0RRC3 Folylpolyglutamate synthase n=1 Tax=alpha proteo... 174 8e-42 UniRef50_C6XMV8 FolC bifunctional protein n=1 Tax=Hirschia balti... 173 9e-42 UniRef50_B1I4S5 FolC bifunctional protein n=1 Tax=Candidatus Des... 173 1e-41 UniRef50_A6DMK1 Folylpolyglutamate synthase n=1 Tax=Lentisphaera... 173 1e-41 UniRef50_Q97AP2 Folylpolyglutamate synthase n=2 Tax=Thermoplasma... 172 2e-41 UniRef50_D1R940 Putative uncharacterized protein n=1 Tax=Parachl... 172 2e-41 UniRef50_C7NET4 FolC bifunctional protein n=3 Tax=Leptotrichia R... 171 3e-41 UniRef50_B2A1F3 FolC bifunctional protein n=1 Tax=Natranaerobius... 171 3e-41 UniRef50_B9LS84 Dihydropteroate synthase n=5 Tax=cellular organi... 171 3e-41 UniRef50_Q2LQC5 Folylpolyglutamate synthase / dihydrofolate synt... 171 4e-41 UniRef50_P15925 Folylpolyglutamate synthase n=9 Tax=Lactobacillu... 171 4e-41 UniRef50_C6D869 FolC bifunctional protein n=3 Tax=Bacillales Rep... 171 4e-41 UniRef50_A8YUM7 Folylpolyglutamate synthase n=28 Tax=Lactobacill... 171 5e-41 UniRef50_C1I5V8 FolC bifunctional protein n=1 Tax=Clostridium sp... 171 5e-41 UniRef50_D1AJ52 FolC bifunctional protein n=1 Tax=Sebaldella ter... 171 5e-41 UniRef50_UPI0001745D4D FolC bifunctional protein n=1 Tax=Verruco... 171 6e-41 UniRef50_Q13EP9 FolC bifunctional protein n=37 Tax=Alphaproteoba... 171 6e-41 UniRef50_C8QY00 FolC bifunctional protein n=1 Tax=Desulfurivibri... 170 7e-41 UniRef50_D1BNH4 FolC bifunctional protein n=3 Tax=Veillonella Re... 170 9e-41 UniRef50_Q6AJ73 Related to folylpolyglutamate synthase n=3 Tax=D... 170 9e-41 UniRef50_A9BIJ6 FolC bifunctional protein n=1 Tax=Petrotoga mobi... 170 1e-40 UniRef50_A5I6P2 FolC bifunctional protein n=14 Tax=Clostridia Re... 170 1e-40 UniRef50_UPI0001BC3950 FolC bifunctional protein n=1 Tax=Butyriv... 170 1e-40 UniRef50_C9LMI1 Tetrahydrofolate synthase n=1 Tax=Dialister invi... 169 1e-40 UniRef50_B3DQR8 Folylpolyglutamate synthase n=18 Tax=Bifidobacte... 169 2e-40 UniRef50_A6C8Q2 Folyl-polyglutamate synthetase n=1 Tax=Planctomy... 169 2e-40 UniRef50_Q67SJ1 Folylpolyglutamate synthase n=1 Tax=Symbiobacter... 169 2e-40 UniRef50_Q18JB6 Folylpolyglutamate synthase / dihydropteroate sy... 169 2e-40 UniRef50_A1HP48 FolC bifunctional protein n=1 Tax=Thermosinus ca... 169 3e-40 UniRef50_B5YD69 Folylpolyglutamate synthase n=1 Tax=Dictyoglomus... 168 3e-40 UniRef50_C9L620 Tetrahydrofolate synthase n=1 Tax=Blautia hansen... 168 4e-40 UniRef50_D0LYA5 FolC bifunctional protein n=1 Tax=Haliangium och... 168 4e-40 UniRef50_A1ZCQ8 Folylpolyglutamate synthase n=1 Tax=Microscilla ... 168 4e-40 UniRef50_C7P2D7 FolC bifunctional protein n=4 Tax=Halobacteriace... 168 4e-40 UniRef50_B8I1X5 FolC bifunctional protein n=2 Tax=Clostridium Re... 167 6e-40 UniRef50_D1BZM6 FolC bifunctional protein n=10 Tax=Actinomycetal... 167 6e-40 UniRef50_Q1PZI3 Similar to multifunctional folylpolyglutamate sy... 167 6e-40 UniRef50_C2E893 Folylpolyglutamate synthase / dihydrofolate synt... 167 6e-40 UniRef50_D2R4J4 FolC bifunctional protein n=1 Tax=Pirellula stal... 167 6e-40 UniRef50_B6JCP5 FolC bifunctional protein n=17 Tax=Alphaproteoba... 166 1e-39 UniRef50_Q38XD0 Putative polylpolyglutamate synthase n=1 Tax=Lac... 166 1e-39 UniRef50_D0WR93 Tetrahydrofolate synthase n=2 Tax=Actinomycetale... 166 1e-39 UniRef50_C6J218 Bifunctional protein folC n=1 Tax=Paenibacillus ... 166 2e-39 UniRef50_UPI00016C3FCF FolC bifunctional protein n=1 Tax=Gemmata... 166 2e-39 UniRef50_C0GEY6 FolC bifunctional protein n=1 Tax=Dethiobacter a... 165 3e-39 UniRef50_Q5SLF0 Folyl-polyglutamate synthetase n=6 Tax=Deinococc... 164 4e-39 UniRef50_D0JAL7 Bifunctional folylpolyglutamate synthase/dihydro... 164 4e-39 UniRef50_B1YJU6 FolC bifunctional protein n=2 Tax=Exiguobacteriu... 164 5e-39 UniRef50_Q9K8G9 Folyl-polyglutamate synthetase n=1 Tax=Bacillus ... 164 6e-39 UniRef50_A3ZWP1 Folyl-polyglutamate synthetase n=1 Tax=Blastopir... 164 7e-39 UniRef50_C6W460 FolC bifunctional protein n=7 Tax=Bacteroidetes ... 163 1e-38 UniRef50_B7L3L1 FolC bifunctional protein n=2 Tax=Methylobacteri... 163 1e-38 UniRef50_C7GYL0 Tetrahydrofolate synthase n=1 Tax=Eubacterium sa... 162 2e-38 UniRef50_B1VGM7 Dihydrofolate synthase / folylpolyglutamate synt... 162 2e-38 UniRef50_A5V9W9 FolC bifunctional protein n=6 Tax=Sphingomonadac... 162 2e-38 UniRef50_D1CGA1 FolC bifunctional protein n=1 Tax=Thermobaculum ... 162 2e-38 UniRef50_B7CA46 Putative uncharacterized protein n=1 Tax=Eubacte... 162 3e-38 UniRef50_B5IFG1 FolC bifunctional protein n=2 Tax=Aciduliprofund... 161 4e-38 UniRef50_Q4FND2 FolC bifunctional protein (Folylpolyglutamate sy... 161 5e-38 UniRef50_C4V4R4 Possible tetrahydrofolate synthase n=2 Tax=Selen... 161 5e-38 UniRef50_Q05865 Folylpolyglutamate synthase n=5 Tax=Bacillus sub... 160 6e-38 UniRef50_C2KWA8 Possible tetrahydrofolate synthase n=1 Tax=Oriba... 160 7e-38 UniRef50_C2BRT3 Possible tetrahydrofolate synthase n=3 Tax=Mobil... 160 9e-38 UniRef50_Q6G1D4 Folylpolyglutamate synthase n=2 Tax=Bartonella R... 160 9e-38 UniRef50_D2RA71 Bifunctional protein FolC n=3 Tax=Bifidobacteria... 160 1e-37 UniRef50_D1PK55 Tetrahydrofolate synthase n=1 Tax=Subdoligranulu... 160 1e-37 UniRef50_A8MIR1 FolC bifunctional protein n=1 Tax=Alkaliphilus o... 160 1e-37 UniRef50_D0MSD1 Folylpolyglutamate synthase, putative n=1 Tax=Ph... 159 1e-37 UniRef50_A9QPJ9 Folylpolyglutamate synthase n=1 Tax=Methylacidip... 159 2e-37 UniRef50_Q6KZL1 Folylpolyglutamate synthase/dihydrofolate syntha... 159 2e-37 UniRef50_B8J1M9 FolC bifunctional protein n=1 Tax=Desulfovibrio ... 159 2e-37 UniRef50_A8UBK8 Folyl-polyglutamate synthetase n=1 Tax=Carnobact... 159 3e-37 UniRef50_C6HY59 Folylpolyglutamate synthase n=1 Tax=Leptospirill... 158 3e-37 UniRef50_A7HJX6 FolC bifunctional protein n=3 Tax=Thermotogaceae... 158 4e-37 UniRef50_C9KNY5 Tetrahydrofolate synthase n=2 Tax=Veillonellacea... 158 4e-37 UniRef50_Q1IVH6 FolC bifunctional protein n=2 Tax=Acidobacteria ... 158 4e-37 UniRef50_Q2GGC6 Folylpolyglutamate synthase n=11 Tax=Rickettsial... 157 5e-37 UniRef50_B9JXV9 Folylpolyglutamate synthase n=81 Tax=Alphaproteo... 157 5e-37 UniRef50_Q0BWJ9 Putative folylpolyglutamate synthase n=1 Tax=Hyp... 157 6e-37 UniRef50_Q2GD55 Folylpolyglutamate synthase n=2 Tax=Neorickettsi... 157 7e-37 UniRef50_B4UGX6 FolC bifunctional protein n=4 Tax=Anaeromyxobact... 157 8e-37 UniRef50_A5CR24 FolC protein n=6 Tax=Actinobacteria (class) RepI... 157 9e-37 UniRef50_Q1MS38 Folylpolyglutamate synthase n=1 Tax=Lawsonia int... 156 1e-36 UniRef50_B6IV82 FolC bifunctional protein n=5 Tax=Alphaproteobac... 156 1e-36 UniRef50_Q02Z16 Folylpolyglutamate synthase n=20 Tax=Bacteria Re... 156 1e-36 UniRef50_C8X0V4 FolC bifunctional protein n=1 Tax=Desulfohalobiu... 156 1e-36 UniRef50_C6LLD0 Tetrahydrofolate synthase n=3 Tax=Clostridiales ... 156 1e-36 UniRef50_A8RF48 Putative uncharacterized protein n=1 Tax=Eubacte... 156 2e-36 UniRef50_Q3ZAH8 Folylpolyglutamate synthetase n=5 Tax=Dehalococc... 155 2e-36 UniRef50_A5N275 FolC n=22 Tax=Clostridium RepID=A5N275_CLOK5 155 2e-36 UniRef50_C6VI65 Folylpolyglutamate synthase n=8 Tax=Bacilli RepI... 155 3e-36 UniRef50_A5FWT1 FolC bifunctional protein n=1 Tax=Acidiphilium c... 155 3e-36 UniRef50_C0W165 Possible tetrahydrofolate synthase n=1 Tax=Actin... 155 3e-36 UniRef50_A5VL10 FolC bifunctional protein n=8 Tax=Lactobacillus ... 155 3e-36 UniRef50_C7MB66 Folylpolyglutamate synthase/dihydrofolate syntha... 154 4e-36 UniRef50_B1HVC8 Folylpolyglutamate synthase n=2 Tax=Bacillaceae ... 154 4e-36 UniRef50_C0EVS7 Putative uncharacterized protein n=1 Tax=Eubacte... 154 4e-36 UniRef50_D1AAV2 FolC bifunctional protein n=1 Tax=Thermomonospor... 154 5e-36 UniRef50_A0LA36 FolC bifunctional protein n=2 Tax=cellular organ... 154 5e-36 UniRef50_Q8KFQ9 Folylpolyglutamate synthase n=1 Tax=Chlorobaculu... 154 5e-36 UniRef50_C1CYP7 Putative tetrahydrofolate synthase (Folylpolyglu... 154 5e-36 UniRef50_B3E778 FolC bifunctional protein n=3 Tax=Desulfuromonad... 154 7e-36 >UniRef50_B5FFN4 Bifunctional protein FolC n=7 Tax=Vibrionaceae RepID=B5FFN4_VIBFM Length = 426 Score = 424 bits (1091), Expect = e-117, Method: Compositional matrix adjust. Identities = 220/420 (52%), Positives = 287/420 (68%), Gaps = 8/420 (1%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M +P+A S L+ WL YLE++H+ IDLGL+RV VA R + KPAP V TVAGTNGK Sbjct: 1 MTTFDSPKATSDLSMWLRYLESIHTSAIDLGLDRVQRVAQRAKLTKPAPTVITVAGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 G+TC +ESIL+ AGY+VGVYSSPHL+RY ER+R+ G +L +S + SFA IE+ R DIS Sbjct: 61 GSTCALMESILINAGYRVGVYSSPHLIRYNERIRINGNDLSDSLISQSFAAIEAWRKDIS 120 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 L+ FE+GTLSALW FK Q+DVV+LEVGLGGRLDATN+VD DV+++TS+A+DH DWLG D Sbjct: 121 LSLFEFGTLSALWAFKAHQVDVVLLEVGLGGRLDATNVVDHDVSIITSLAVDHVDWLGDD 180 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV--TDHDWAF 238 E IG EKAGIFRSEK AI G+P PS++A A + A L + G +++Y+V W++ Sbjct: 181 IEVIGFEKAGIFRSEKAAICGQPNPPSSVAAHADDINADLYQVGYQFDYNVHADTQTWSW 240 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSE--- 295 L+NLPLP +P NAATA+ AL SGLE+S+ I +G+ SA LPGR Q ++ Sbjct: 241 KSGAFDLDNLPLPNLPLANAATAIMALGVSGLELSDINIVEGLKSARLPGRMQRLTRGNS 300 Query: 296 --SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 P +I DVAHNPH+A YL +++ N ++ AV+GMLHDKDI TL V+D WY Sbjct: 301 EFEPTIILDVAHNPHSAHYLVQQVRQRFPNKKIHAVVGMLHDKDIKSTLGEFTGVIDVWY 360 Query: 354 CAPLEGPRGATAEQLLEHLGNG-KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A L GPR A A +L L + S A+ A+ A+++D +LV GSFHTV V + Sbjct: 361 PASLSGPRAANASELTAVLSKEITEYSSPVDAFKVALQQAESDDLILVFGSFHTVGEVWD 420 >UniRef50_P43775 Folylpolyglutamate synthase n=258 Tax=Gammaproteobacteria RepID=FOLC_HAEIN Length = 437 Score = 415 bits (1066), Expect = e-114, Method: Compositional matrix adjust. Identities = 214/432 (49%), Positives = 281/432 (65%), Gaps = 25/432 (5%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 +A SPLA WLSYLE H K IDLGL+R+ VA +L +L P P+V TV GTNGKGTTCR L Sbjct: 7 KATSPLAEWLSYLEKSHFKPIDLGLDRIKSVAEKLDLLHPVPYVITVGGTNGKGTTCRLL 66 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 E+IL+ G +VGVYSSPHL+RY ERVR+Q Q+LP+ AHTASFA I+ + + SLTYFE+ Sbjct: 67 ETILLNHGLRVGVYSSPHLLRYNERVRIQNQDLPDEAHTASFAFIDENKTE-SLTYFEFS 125 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 TLSAL LFKQA+LDVVILEVGLGGRLDATNIVD+ +AV+TSI +DHTD+LG RE+I E Sbjct: 126 TLSALHLFKQAKLDVVILEVGLGGRLDATNIVDSHLAVITSIDIDHTDFLGDTREAIAFE 185 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 KAGIFR P ++GEP +P T+ D A++ + RR V+W + +W + + LEN Sbjct: 186 KAGIFRENCPVVIGEPNVPQTMLDQAEKLHCQVARRDVDWLFEQNAENWQWQNKKVRLEN 245 Query: 248 LPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES----------- 296 LP +P NAAT LAA++ ++SE +R + L GRFQ + Sbjct: 246 LPFCQIPLANAATVLAAVQYLPFDISEQTLRKSLQEVELVGRFQAIKTDKREKLADYLGV 305 Query: 297 -----PRVIFDVAHNPHAAEYLTGRMKALPKN--GRVLAVIGMLHDKDIAGTLAWLKSVV 349 P +I DV HNPHAA+YL+ ++ AL ++ G+++AV GML DKD G L ++ Sbjct: 306 PVETLPTIIVDVGHNPHAAKYLSEKLTALKRSIEGKMIAVCGMLKDKDANGVFEHLTPII 365 Query: 350 DDWYCAPLEGPRGATAEQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 D+W+C L G RG + ++L+E L + S +SV A+ A D VLV GS Sbjct: 366 DEWHCVTLGGYRGQSGDELVEKLKSHFPNIQATSDNSVMDGVCTALKSAVKNDVVLVFGS 425 Query: 404 FHTVAHVMEVID 415 FHTVA V++ Sbjct: 426 FHTVAEFWAVVE 437 >UniRef50_Q492H5 Folylpolyglutamate synthase n=3 Tax=Enterobacteriaceae RepID=Q492H5_BLOPB Length = 424 Score = 412 bits (1059), Expect = e-113, Method: Compositional matrix adjust. Identities = 210/419 (50%), Positives = 281/419 (67%), Gaps = 7/419 (1%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 I TP S L WL+Y+E+L IDL L+RV +A LG++ PA +V V GTNGKGT Sbjct: 4 IFHTPPERSSLGKWLNYIESLSHVLIDLNLDRVRKIAINLGLMHPAEYVILVGGTNGKGT 63 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 TC LE+IL+ VG+Y+SPHL+ Y ER+RV G+ELP+S H + + IES R I+LT Sbjct: 64 TCCLLETILLNNNNTVGLYTSPHLLSYNERIRVCGKELPDSIHIEALSVIESVRHHIALT 123 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+ TLSAL++FK+A+LDVVILEVGLGGRLDATNIV+ D++V+T+ A+DHTD+LG +R+ Sbjct: 124 YFEFITLSALYIFKRAKLDVVILEVGLGGRLDATNIVNPDISVITNFAIDHTDFLGINRD 183 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF---S 239 I +EK+GIFR KPA++GE P +AQ GA+L RG +WN+ V + W + S Sbjct: 184 MIAQEKSGIFRFNKPAVIGESCFPVIARKMAQYCGAMLFARGRDWNFRVYGNKWIWWECS 243 Query: 240 DAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 + + L +LPLP++P NAATAL+ L V + AI G+ A LPGRFQIV+ P Sbjct: 244 NEYKLLYDLPLPIIPIENAATALSVLYWLPFLVDKTAISYGLQVATLPGRFQIVTRRPIA 303 Query: 300 IFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 I DV HNPHAA YLT R+ L K G+V VIGML +KDI GT+ L +VD WYC+ L Sbjct: 304 ILDVGHNPHAANYLTKRLPVLLKRRTGKVRMVIGMLKNKDIQGTIYCLSHLVDVWYCSDL 363 Query: 358 EGPRGATAEQLLEHL--GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 P A++ +L + L N + F ++ AW+ A+ DA +D +LV GSFH V+ +M I Sbjct: 364 NVPFSASSVELSDCLLHCNVQIFSNILDAWNQAVLDASFDDCILVFGSFHAVSPIMRNI 422 >UniRef50_Q12P54 FolC bifunctional protein n=10 Tax=Shewanella RepID=Q12P54_SHEDO Length = 448 Score = 403 bits (1035), Expect = e-111, Method: Compositional matrix adjust. Identities = 207/425 (48%), Positives = 286/425 (67%), Gaps = 18/425 (4%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCR 65 P+ + L WL YL ++H ID+GL RVS VA +L +L AP V TVAGTNGKGT+C Sbjct: 23 PKQGATLQDWLDYLLSIHPAEIDMGLSRVSQVAKQLQLLDLAPAQVITVAGTNGKGTSCA 82 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 LES+L AG +VGVYSSPHL+ Y ERVR+QG + + A A+F+ IE+ARG ISLT+FE Sbjct: 83 MLESVLSFAGKRVGVYSSPHLIHYNERVRIQGVDASDEALIAAFSAIEAARGAISLTFFE 142 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 Y TL+ LWLFK A+LDV+ILEVGLGGRLDATN++DAD+ ++TSIALDH ++LG RE++G Sbjct: 143 YATLAGLWLFKAAKLDVIILEVGLGGRLDATNMIDADICLLTSIALDHQEYLGDTREAVG 202 Query: 186 REKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 REKAG+FR+ + A++GEP +P T+ D A++ G + R G E++Y + W+F+ + + Sbjct: 203 REKAGVFRANRLAVIGEPALPITVTDYAEQIGTPVCRVGHEFSYEAQGNTWSFNSPNRQI 262 Query: 246 ENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 L LP++P NAA+ +A L E+S+ + GI A L GRF+ +S SP VI DVAH Sbjct: 263 AALALPVLPLANAASVVALLTQRWPEISDEQLSLGIGQARLAGRFETLSTSPLVIVDVAH 322 Query: 306 NPHAAEYLTGRMKALPKNG-RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 NPHAA YL ++ NG R+LA+ ML DKD+AG L+ L VVD WY A L+ RGA+ Sbjct: 323 NPHAAAYLAKQLSVF--NGKRILALCAMLKDKDMAGVLSELTDVVDAWYFASLQNERGAS 380 Query: 365 AEQLLEHLGNGKS--------------FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 A QL L ++ F+S++Q W A +A+ +D ++V GSF+TVA + Sbjct: 381 ASQLSAALEQTQAQALEVNLALTQVLEFESLSQGWKALTLEAQEDDIIIVFGSFYTVAGI 440 Query: 411 MEVID 415 +++ Sbjct: 441 KALLE 445 >UniRef50_C6AMR7 FolC bifunctional protein n=3 Tax=Pasteurellaceae RepID=C6AMR7_AGGAN Length = 448 Score = 397 bits (1020), Expect = e-109, Method: Compositional matrix adjust. Identities = 222/439 (50%), Positives = 278/439 (63%), Gaps = 36/439 (8%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 +A +PL WLSYLEN H K IDLGLERV VA L +L PAP+V TV GTNGKGTTCR L Sbjct: 6 KATTPLNEWLSYLENSHFKAIDLGLERVKSVAQELDLLTPAPYVITVGGTNGKGTTCRLL 65 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 E+IL+ AGY VGVYSSPHL+RY ERVR+Q QEL ++ HTASFA IE+ + SLTYFE+ Sbjct: 66 ETILLNAGYSVGVYSSPHLLRYNERVRIQNQELDDAQHTASFAYIEAHKSQ-SLTYFEFS 124 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 TLSAL LFK A+LDVVILEVGLGGRLDATNIVD +AV+TSI +DHTD+LG RE IG E Sbjct: 125 TLSALHLFKCAKLDVVILEVGLGGRLDATNIVDNHMAVITSIDIDHTDFLGSTREQIGFE 184 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH----- 242 KAGIFR+ KP I+GEP +P + D A + G+ R ++W +S W + Sbjct: 185 KAGIFRANKPVIIGEPMIPQAMLDRANQLGSQHFCRHLDWTFSQQGQSWTWQTTQSDEKV 244 Query: 243 --GTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQI-------- 292 L +LPL +P NAATALAA++ E+S + ++ +A L GRFQ Sbjct: 245 RWNFLTDLPLCQIPLANAATALAAVQKLPFEISLDVVKKSLAEVELIGRFQTLKPECLAH 304 Query: 293 --------VSESPRVIFDVAHNPHAAEYLTGRMKALP--KNGRVLAVIGMLHDKDIAGTL 342 VS+ P++I DV HNPHAA YL ++ AL NG+ +AV GML DKD G L Sbjct: 305 LAQKLNRHVSQLPQMIIDVGHNPHAARYLAEKLTALKAQSNGKFIAVCGMLKDKDAEGVL 364 Query: 343 AWLKSVVDDWYCAPLEGPRGATAEQLL----------EHLGNGKSFDSVAQAWDAAMADA 392 L ++D+W C L G RG T EQL + + G +SVA+ +A+ + Sbjct: 365 EPLLPLIDEWRCVTLGGYRGQTGEQLFVTLQQTARLHQKVVKGSYSNSVAEGVKSAVEIS 424 Query: 393 KAEDTVLVCGSFHTVAHVM 411 DT+LV GSFHTV + Sbjct: 425 NENDTLLVFGSFHTVGEFL 443 >UniRef50_Q8K9X3 Dihydrofolate synthase n=1 Tax=Buchnera aphidicola (Schizaphis graminum) RepID=FOLC_BUCAP Length = 418 Score = 389 bits (999), Expect = e-106, Method: Compositional matrix adjust. Identities = 186/409 (45%), Positives = 267/409 (65%), Gaps = 4/409 (0%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 + W+ YLE K L + L+A +LG+L F FTV GTNGKGTTC LE +L Sbjct: 7 TFSMWMKYLEKFDKKDRK-NLFELKLIAKKLGLLNLKSFFFTVGGTNGKGTTCAMLEKLL 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 + +GY+VG+Y+SPHL+ Y+ER++V G L E H SF I++ +G++SLTYFE+ TLSA Sbjct: 66 LDSGYQVGLYTSPHLINYSERIKVNGLYLSEKDHIFSFLIIDAEKGNVSLTYFEFITLSA 125 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 L+LF Q LD++ILEVGLGGRLDATNI+D+D++V+T+I +DHT LG DR SIGREK+GI Sbjct: 126 LFLFSQYSLDIIILEVGLGGRLDATNIIDSDLSVITNIGIDHTSCLGTDRISIGREKSGI 185 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-WAFSDAHGTLENLPL 250 FR K A++GE +P ++ ++A+EK +L++ V+W ++ T D W F ++ L NLP+ Sbjct: 186 FRKGKIAVIGEKNIPISVDEIAKEKKTILKKIDVDWFWTRTKIDSWNFIHSNIELYNLPV 245 Query: 251 PLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 +P N A ALA+L SGLEV+ ++ I+ L GRFQ V SPR+I DVAHN HAA Sbjct: 246 SRIPLSNTAIALASLFYSGLEVNLKKLKSSISKVQLSGRFQTVFNSPRIILDVAHNVHAA 305 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 YL+ ++ + G++ AV G+L DKD+AG + L+ ++ WY L+ R A+ L + Sbjct: 306 LYLSEKIDEIDTEGQIYAVFGILKDKDVAGVVQVLQKKINYWYVVNLKTNRSASINYLKK 365 Query: 371 H--LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 L N F+++ ++W A +D +LV GSF TV+ M + D R Sbjct: 366 KLSLNNALFFNNINESWQAIKKVITKKDIILVFGSFFTVSEFMSIKDRR 414 >UniRef50_B0UU80 FolC bifunctional protein n=14 Tax=Pasteurellaceae RepID=B0UU80_HAES2 Length = 443 Score = 384 bits (986), Expect = e-105, Method: Compositional matrix adjust. Identities = 205/436 (47%), Positives = 280/436 (64%), Gaps = 31/436 (7%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 A SPL WL +LE H+K IDLGL+RV VA +L +L+PAPFV TV GTNGKGTTCR LE Sbjct: 9 ATSPLEQWLCFLEKAHAKAIDLGLDRVKTVAQQLDLLQPAPFVITVGGTNGKGTTCRLLE 68 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 +L+ +G++VGVYSSPHL+RY ERVR+Q QEL + HT +FA IE + SLTYFE+ T Sbjct: 69 ILLLNSGFRVGVYSSPHLIRYNERVRIQNQELADEEHTQAFAFIEQHKSQ-SLTYFEFST 127 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 LSAL+LFKQA LDVVILEVGLGGRLDATNIVDAD+AV+TSI +DHTD+LG RE I EK Sbjct: 128 LSALYLFKQANLDVVILEVGLGGRLDATNIVDADLAVITSIDIDHTDFLGNTREEIAFEK 187 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT---- 244 +GIFR KPA++GE +P ++ + ++ ++L R +W +S ++ W + G Sbjct: 188 SGIFRPNKPAVIGENNIPCSLLEQGKKLDSILFCRNKDWKFSKQENGWTWETIKGNKAIY 247 Query: 245 LENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQ------------- 291 ++NLP+ +P NAATALA L ++S + I + L GRFQ Sbjct: 248 MDNLPICSIPLANAATALATLAYLPFDISISVIHKSLREVELAGRFQKINPEKLLNLAKL 307 Query: 292 ---IVSESPRVIFDVAHNPHAAEYLTGRMKALPKN--GRVLAVIGMLHDKDIAGTLAWLK 346 V + P++I DV HNPHAA YL R+ AL G++++V G+L DKD G L+ L Sbjct: 308 SKKTVKQLPQIIVDVGHNPHAASYLLERLTALKAKSIGKIISVCGILKDKDSQGILSPLI 367 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHLG--------NGKSFDSVAQAWDAAMADAKAEDTV 398 VVD W L+G RG ++ +L L + +++ SV + +A+ +A +D + Sbjct: 368 KVVDQWNLVTLDGVRGQSSHELFMTLQQISTTNELSAQTYSSVYEGVKSAVQNATEKDII 427 Query: 399 LVCGSFHTVAHVMEVI 414 LV GSF+TV ++++ Sbjct: 428 LVFGSFYTVGSFLKLL 443 >UniRef50_Q5QWH7 Folylpolyglutamate synthase n=2 Tax=Idiomarina RepID=Q5QWH7_IDILO Length = 430 Score = 366 bits (940), Expect = e-100, Method: Compositional matrix adjust. Identities = 208/422 (49%), Positives = 258/422 (61%), Gaps = 15/422 (3%) Query: 2 IIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 I P + L WL+YLE LH K ID+GLERV+ VAA GVLKPA V TV+GTNGKG Sbjct: 4 ISSSAPAVTASLQEWLTYLEKLHPKNIDMGLERVARVAANAGVLKPAALVITVSGTNGKG 63 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL 121 +T LE+IL AAGY GVY+SPH+ Y ERVRV QELP+S H +F IE AR + SL Sbjct: 64 STVCYLETILQAAGYTTGVYTSPHITEYRERVRVNAQELPDSEHVKAFHAIEQARNNTSL 123 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 TYFE+GTL+ALWL + DV ILEVGLGGRLDA N VDADVAVVTSI +DH +LG +R Sbjct: 124 TYFEFGTLAALWLMGRQSPDVAILEVGLGGRLDAVNCVDADVAVVTSIGIDHIAFLGNNR 183 Query: 182 ESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 E IG EKAGI RS KP I GE ++IA+ A+ GA L + G +++ + D W++ Sbjct: 184 EHIGYEKAGIARSGKPLICGEASPTASIAESAERIGAKLYQVGRDFHRTEYDESWSYRSQ 243 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQI-VSESPRVI 300 + L +LPLP +P NA+TA+AA+ L VS +AIR+GI A LPGR Q V+ Sbjct: 244 NTQLNDLPLPKLPLINASTAIAAIEQLPLPVSLSAIREGITQASLPGRMQPDTVNGIEVL 303 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHNP AA Y + + ++ AV+GML DKD AG L S WY L P Sbjct: 304 LDVAHNPQAAVYASRYLNKFYPQHKIFAVVGMLSDKDHAGVANALSSQASAWYLGSLSEP 363 Query: 361 RGATAEQLLEHLG----NGKSFDSV--------AQAWDAAMADAKAEDTVLVCGSFHTVA 408 RG TA+ L+ + + F+SV A M D KA V GSF+TVA Sbjct: 364 RGETADNLVINAKLPTESCYLFESVEQAFAAAVTAAQQWQMNDGKA--LVFGFGSFYTVA 421 Query: 409 HV 410 + Sbjct: 422 RI 423 >UniRef50_Q89AT2 Dihydrofolate synthase n=4 Tax=Buchnera aphidicola RepID=FOLC_BUCBP Length = 426 Score = 365 bits (936), Expect = 2e-99, Method: Compositional matrix adjust. Identities = 182/411 (44%), Positives = 262/411 (63%), Gaps = 4/411 (0%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 MI K+ ++ S L WL YL++ ID L RV VA +LGVLK FVF V GTNGK Sbjct: 1 MINKKLARSFS-LYEWLYYLDHFMLDNIDPTLNRVFYVAKKLGVLKSKAFVFIVGGTNGK 59 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 G+TC LE++L+ +GY+VG+Y+SPHL+RYTERVR+ G EL H ++F +++ + D+ Sbjct: 60 GSTCHVLENLLLNSGYRVGLYTSPHLMRYTERVRINGFELEHLYHISAFNDVKYFQNDVL 119 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 LT FE+ TLSAL LFK LD++ILEVGLGGRLDATNI+ ADV+V+T+I +DH+ LG + Sbjct: 120 LTRFEFITLSALILFKSYNLDIIILEVGLGGRLDATNILSADVSVITNIDIDHSKILGVN 179 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD 240 R SI EK+GIFR K AIV + P +A++K L+ ++W Y + +W+F Sbjct: 180 RSSISVEKSGIFRKNKIAIVADNNFPKVAQYLAKKKKVRLRIVNIDWIYKKIEFEWSFCS 239 Query: 241 AHGTLENLPLPL-VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 + T +LPLP V + ATAL+A+ SG+++++ R I+ L GRF+ +S +P + Sbjct: 240 SKITWLHLPLPRNVSLDSVATALSAVSESGIKINQKVFRSCISEITLCGRFETISYNPII 299 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 I DVAHNPH+A YL +M + KNG + AV+G+L +K+I ++ L +VD WYC L Sbjct: 300 ILDVAHNPHSARYLFKKMSSFKKNGNIFAVVGILKEKNIKDIVSPLIPIVDYWYCITLLT 359 Query: 360 PRGATAEQLLEHLGNGKS--FDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 R AT+ +++++L N S ++ A + D VL+ GSF TV Sbjct: 360 HRSATSSEIIKYLPNHNSQISKNMTVALEKIFDKVTNNDIVLIFGSFITVC 410 >UniRef50_A6FEP3 Dihydrofolate synthase / folylpolyglutamate synthase n=1 Tax=Moritella sp. PE36 RepID=A6FEP3_9GAMM Length = 441 Score = 360 bits (924), Expect = 6e-98, Method: Compositional matrix adjust. Identities = 216/431 (50%), Positives = 272/431 (63%), Gaps = 31/431 (7%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 LA WL YLE++H I++GL R+ VAA L + A V TVAGTNGKG+TC LE IL+ Sbjct: 11 LADWLCYLESIHPVNIEMGLGRIGRVAADLALTTFAAKVITVAGTNGKGSTCAFLERILL 70 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AG+ VGV SSPH+ Y ERVRV G+ L AH SFA IE+ RGD +LTYFE+ TLS+L Sbjct: 71 DAGFNVGVTSSPHIQDYRERVRVNGKMLTAQAHADSFAFIEAGRGDTTLTYFEFTTLSSL 130 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 LF+ A LDVVILEVGLGGRLDA+NIV ADVAVVT+I +DH DWLG D+ I REKAGIF Sbjct: 131 KLFQDAALDVVILEVGLGGRLDASNIVSADVAVVTTIDIDHADWLGTDKAVIAREKAGIF 190 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH----DWAFS-----DAHG 243 R+ K AI G PSTIA A+E GA L V +Y T H DW + DA Sbjct: 191 RAGKKAICGVINPPSTIAAYAEEVGADL--IAVNRDYYYTQHADTWDWQSNPTEQQDASA 248 Query: 244 -TLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 T L +P +P NAATA+AA++A GL V + AI G+ASA LPGR Q + SP+ D Sbjct: 249 LTFTALEIPQLPLQNAATAIAAIQALGLTVPDTAIHSGVASARLPGRMQQLGTSPQQFLD 308 Query: 303 VAHNPHAAEYLTGRMKALPKNG----RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 VAHNP +A YL ++ L + +++AV+GML DKDIA +LA L V+D W+ A L+ Sbjct: 309 VAHNPESARYLASQLTRLKQQASSPVKIIAVVGMLKDKDIAASLAALTDVIDCWHLAALQ 368 Query: 359 GPRGATAEQLLEHL-----GNGKSFDS----------VAQAWDAAMADAKAEDTVLVCGS 403 G R A +Q+ + L N KS DS +A+AW +A A D ++ GS Sbjct: 369 GERAAPCQQIEQGLVAAMQQNSKSRDSLRQQPMSHDTIAKAWQSANQSADCNDIIIGFGS 428 Query: 404 FHTVAHVMEVI 414 F TVA +++ I Sbjct: 429 FFTVAEIIQHI 439 >UniRef50_A1SW71 FolC bifunctional protein n=2 Tax=Psychromonas RepID=A1SW71_PSYIN Length = 428 Score = 360 bits (923), Expect = 7e-98, Method: Compositional matrix adjust. Identities = 188/425 (44%), Positives = 269/425 (63%), Gaps = 17/425 (4%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 +I ++ PQ L WL+Y+E LH IDLGL R++ VA+ L V+ V TVAGTNGK Sbjct: 4 VIPQKLPQT---LPQWLAYIEILHPSAIDLGLSRIAKVASALQVINFDAQVITVAGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 GTTC LE IL+ AG+KVGVYSSPH+ RYTER+R+ QEL + AH +F+ IE R + S Sbjct: 61 GTTCAFLEEILLQAGFKVGVYSSPHIQRYTERLRINKQELSDQAHCDAFSAIEKIRKETS 120 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 L+YFEY TL L L KQA D ++LEVGLGGRLDATN+V++D +V+T+I +DH DWLG D Sbjct: 121 LSYFEYATLGCLSLLKQAHCDYILLEVGLGGRLDATNVVESDASVITTIDIDHIDWLGSD 180 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD 240 RE IG EKAG+FR+ KP I GE + P ++ AQ ++ G +++Y VT W +S Sbjct: 181 REKIGFEKAGVFRANKPVICGEFDPPLSLQAHAQNLNCQIKYAGKDFSYQVTGKQWNWSG 240 Query: 241 AHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP--R 298 TL+++ LPL+P NA+TALA + A ++V+ +++ I +A L GR Q +S + Sbjct: 241 KQ-TLKDIRLPLLPVQNASTALAVIEALQVKVNPAVLKNAIENASLAGRLQKISTTSVCD 299 Query: 299 VIFDVAHNPHAAEYLTGRMKAL----PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 V DVAHNP +A YL +++ + P+ +V A++GML DKDI GT + + +D Sbjct: 300 VYLDVAHNPQSAGYLASQLRLIKAEKPEKCKVHAIVGMLADKDITGTFDQINTEIDFCNL 359 Query: 355 APLEGPRGATAEQLLEHLGNGKS-------FDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 L+ RG +A+ LLE+ K+ F++V A++ + D +++ GSFHTV Sbjct: 360 VSLDCYRGLSADSLLENHQKSKNALTTPICFENVNLAYETVRNKVDSSDIIIIFGSFHTV 419 Query: 408 AHVME 412 + + Sbjct: 420 SDFLN 424 >UniRef50_A6VWY8 FolC bifunctional protein n=2 Tax=Marinomonas RepID=A6VWY8_MARMS Length = 418 Score = 349 bits (895), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 192/412 (46%), Positives = 254/412 (61%), Gaps = 11/412 (2%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 A + LASWLSY+E+ H I+LGLER S V ARL + +P V TVAGTNGKG+TC L Sbjct: 2 AHTSLASWLSYIESQHPSEIELGLERGSKVLARLNLSRPKHKVITVAGTNGKGSTCAMLT 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 L A Y VG Y+SPH + + ER+ + + +F +E AR ISLTYFE+ T Sbjct: 62 QYLCAQNYSVGTYTSPHFIAFNERIALNDSPCDDEVLCRAFEVVEEAREGISLTYFEFST 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+ALW+F Q+ LD +LEVGLGGRLD+ N++D DVAVVTSI+LDH DWLG + + I REK Sbjct: 122 LAALWIFDQSNLDYWVLEVGLGGRLDSVNMMDTDVAVVTSISLDHIDWLGDNLDVIAREK 181 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 AGI R +K I G PSTIA A E GA L+++GV++++ + W++S E L Sbjct: 182 AGIARKDKLLISGVVNPPSTIASTALEVGAHLRQKGVDFHFELDGSTWSWSGDGVQFEKL 241 Query: 249 PLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPH 308 P+P +P NAAT +A L G + + SA L GRFQ V+ SP V DVAHNP Sbjct: 242 PIPALPLQNAATVIAVLVYMGFSPAYADLVTLFDSAQLMGRFQKVATSPDVYIDVAHNPE 301 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 AA L R+ LP + +AV GML DKDIA + L DW+C L GPRGA A +L Sbjct: 302 AAIELAQRISNLPI--QPVAVCGMLKDKDIASVMEHLAGSFSDWFCCDLAGPRGAKASEL 359 Query: 369 LEHLG--------NGKSFDSVAQAWDAAMADAKAED-TVLVCGSFHTVAHVM 411 ++H+ N K+F SV A+ +A+ A+ E +V+V GSF TV++ + Sbjct: 360 IKHIVHSSPSLALNAKAFQSVGDAFSSALVKAQDEQRSVIVFGSFVTVSNYL 411 >UniRef50_Q0AGX2 FolC bifunctional protein n=1 Tax=Nitrosomonas eutropha C91 RepID=Q0AGX2_NITEC Length = 428 Score = 347 bits (890), Expect = 5e-94, Method: Compositional matrix adjust. Identities = 192/416 (46%), Positives = 255/416 (61%), Gaps = 19/416 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WL YLE LH K ID+GLERV V LG++ P V TVAGTNGKG+ C LESIL Sbjct: 9 LDDWLLYLEKLHPKAIDMGLERVKKVRDALGLMPKFP-VITVAGTNGKGSVCTILESILG 67 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLS 130 A Y+VG Y+SPHL+ Y ER+R+ + + + FAEIES R ++LTYFE+GTL+ Sbjct: 68 RASYRVGCYTSPHLLHYGERIRIDQRAITDEVLCGVFAEIESVRESVQVTLTYFEFGTLA 127 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ +F +AQ+DV ILEVGLGGRLDA N+ D D A++TSI LDH D+LG RE+IG+EK G Sbjct: 128 AMLIFVRAQVDVAILEVGLGGRLDAVNVFDTDCAILTSIDLDHMDYLGSTREAIGQEKIG 187 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 IFR KPAI EP++P+ + + GALL + Y+ + W + NL L Sbjct: 188 IFRPNKPAICTEPDIPAGLLPKMKATGALLCCINKNFGYTQDNLQWCYEGVRRY--NLSL 245 Query: 251 PLVP-----QPNAATALAALRASG-LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 P + Q +A A G L V NAIR G+A A L GRFQI+S P +I DVA Sbjct: 246 PALKGEYQLQNASAALAALEAMEGTLPVPMNAIRRGLAEATLAGRFQIISARPVIILDVA 305 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNP A L ++A+P G A++GML DKD+AGT+ LK+ VD W A L+ RGAT Sbjct: 306 HNPAATRKLLANLEAMPVKGCTYAIVGMLKDKDMAGTIRVLKNNVDQWLIAGLDVARGAT 365 Query: 365 AEQLLEHLGNG--------KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 ++L+ LG+ + F +V A+ A A ++D + V GSFHTV+ +++ Sbjct: 366 GNEILKALGDAGIAEQECVRVFQNVQSAYVYAREHAGSDDRICVFGSFHTVSSILK 421 >UniRef50_B6J6W5 Folylpolyglutamate synthase n=6 Tax=Coxiella burnetii RepID=B6J6W5_COXB1 Length = 416 Score = 346 bits (888), Expect = 9e-94, Method: Compositional matrix adjust. Identities = 178/416 (42%), Positives = 258/416 (62%), Gaps = 7/416 (1%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + +WL+Y+ +LHS+ IDLGL R++ +A +L + A V TVAGTNGKG+ ++LESI + Sbjct: 1 MKNWLAYINSLHSREIDLGLSRITSLAEKLSLNNFACPVVTVAGTNGKGSVVKSLESIYL 60 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AAGYKV Y+SPHL+++ ER+R+ G+ + +F IE R L++FE+ TL+ Sbjct: 61 AAGYKVAAYTSPHLLQFNERLRLNGEPATDELFIEAFKFIEDNRNHQPLSFFEFTTLAIF 120 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 ++ K+ LD+++LEVGLGGRLDA NIV+ DVAV+T+I +DHTDWLG DRESIGREKAGI Sbjct: 121 YICKKQNLDILLLEVGLGGRLDAVNIVEPDVAVITTIDIDHTDWLGEDRESIGREKAGII 180 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 R KP I G+P +P+++ + A + ++ T +W + + LPLP Sbjct: 181 RRHKPVIGGDPNLPNSVYEQVHLLEAPFYQLEKDFFAVSTKENWQWQGPTQDYQGLPLPS 240 Query: 253 VPQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 + N AT+L + S L VS++++ GI +A+LPGRF+ + ++FDVAHNP A Sbjct: 241 LKIENIATSLMVIHCLQSQLPVSQHSLIAGIKNAVLPGRFEWIQTPAPIVFDVAHNPQAT 300 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 YL+ +++ GR L V+GML DKDI G L + +D WY L RGAT+ L Sbjct: 301 AYLSEQLRKTDHAGRTLGVVGMLRDKDIPGALKPMLPCIDQWYAGTLSESRGATSANLQN 360 Query: 371 HLG-----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSGG 421 L N FDSVA A+ A+ D + +D ++V GSF+TVA EV+ +G Sbjct: 361 VLSELQVENCYDFDSVADAFKKAVEDCRPQDRIVVFGSFYTVAMAKEVLLGGENGN 416 >UniRef50_Q8D2P3 FolC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2P3_WIGBR Length = 428 Score = 345 bits (885), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 172/414 (41%), Positives = 255/414 (61%), Gaps = 9/414 (2%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P S + W +Y+ LH K IDL L+RV A RL +LKPAP V GTNGKG+TCR Sbjct: 7 PNTHSSIKDWTNYISKLHYKEIDLRLDRVYYFAKRLNLLKPAPITIVVGGTNGKGSTCRF 66 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 LE + + + KVGVYSSPHL+ Y ER+R+ G E+ + + I S++YFE+ Sbjct: 67 LELMFIYSNIKVGVYSSPHLINYNERIRLHGNEVSDEECINAMNFINKIIKKTSISYFEF 126 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 TL AL +FK +LDVVILEVGLGGRLDATN+VD D++VVT++++DHT++LG + I + Sbjct: 127 STLVALLIFKSKKLDVVILEVGLGGRLDATNVVDIDISVVTNVSIDHTEFLGKNCSEIAK 186 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 EK+GIFR +K +I G ++ ++ V W Y W +S+ + Sbjct: 187 EKSGIFRYKKLSIFGGFNNLLNFKSASEYYKSIPYFLNVHWFYKKNKKYWMWSNKTNNIF 246 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 LP P++ NAATALA +++ + +I G+ +A LPGRFQI+++ P +I DVAHN Sbjct: 247 -LPYPILNIENAATALAVIKSLPFTIPYQSIFKGLKTATLPGRFQIINKKPFIILDVAHN 305 Query: 307 PHAAEYLTGRMKALPKNGRVL-AVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGAT 364 P +A++L ++K + KN ++ A+IGML DKDI TL + ++D W CA L E PRGA+ Sbjct: 306 PSSAKHLAKKIKRIKKNFSIIYAIIGMLSDKDIKNTLKYFIKIIDIWNCASLSEFPRGAS 365 Query: 365 AEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 E++ L N K+F +V A+ + A +D +L+ GSF+T++++++ Sbjct: 366 CEEISIFLNKNKEKNNVKNFKNVISAFKYVINIATKKDCILIFGSFYTISYILK 419 >UniRef50_Q88LD8 Folylpolyglutamate synthetase n=23 Tax=Pseudomonadaceae RepID=Q88LD8_PSEPK Length = 436 Score = 344 bits (883), Expect = 3e-93, Method: Compositional matrix adjust. Identities = 198/417 (47%), Positives = 257/417 (61%), Gaps = 14/417 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WL+YLE LH ID+GLER V ARL + K AP V TV GTNGKG+TC + S+L Sbjct: 7 LGEWLAYLEQLHPSAIDMGLERSQKVLARLALGKLAPRVVTVTGTNGKGSTCAFVASLLR 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 A G KVGVYSSPHL+RY ERV + GQE + +FA +E+ARGDISLTYFE GTL+A Sbjct: 67 AQGLKVGVYSSPHLLRYNERVVIDGQEASDERLCEAFAAVEAARGDISLTYFEMGTLAAF 126 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 WLF Q+QLD V+LEVGLGGRLD N+VDAD A+VTSI +DH D+LG RE + EKAGIF Sbjct: 127 WLFYQSQLDAVVLEVGLGGRLDTVNVVDADFALVTSIGVDHVDYLGDTRELVAFEKAGIF 186 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF-----SDAHGTLEN 247 R KPA+ G+ + P + D A E A L RG E++ + + W++ A L + Sbjct: 187 RPGKPALCGDLDPPGPLLDKAAELAAPLFLRGREFDLASAEGCWSWRGTAADGAQVELRD 246 Query: 248 LPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS-----ESPRVIFD 302 LPL +P NA AL A GL + +R + + GR + + + ++ D Sbjct: 247 LPLLDLPMENATLALQAFLLMGLPWNAAQVRQALLDTRITGRLDLRNVNWQGKPVALLLD 306 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 V HNPHAA+YL R+ A P GR LAV G+L DKD+ G +A L+ ++DDW APL+ PR Sbjct: 307 VGHNPHAAQYLARRLAARPLKGRRLAVFGLLADKDLEGVIAPLQGLIDDWAVAPLDTPRS 366 Query: 363 ATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 A +L L N KS+ SV A + A A A+D +L+ GSF VA +E ++ Sbjct: 367 RPAAELASSLANLGATVKSYVSVDAALEGQCAQATADDQILLFGSFFCVAQALEWLE 423 >UniRef50_A2SKX9 Cytoplasmic peptidoglycan synthetase, C-terminal domain n=4 Tax=Betaproteobacteria RepID=A2SKX9_METPP Length = 448 Score = 340 bits (872), Expect = 6e-92, Method: Compositional matrix adjust. Identities = 204/433 (47%), Positives = 264/433 (60%), Gaps = 17/433 (3%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 R P+ + LA+WL++ + LH++TID+GLERV V LG LKP + TVAGTNGKG+TC Sbjct: 16 RRPRQGADLAAWLAHADALHAQTIDMGLERVVKVRDALG-LKPGFPLITVAGTNGKGSTC 74 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L S+L AAGY+VGVYSSPHL+RY ERVR+ G + ++A A++A +E ARG LT F Sbjct: 75 ALLASVLGAAGYRVGVYSSPHLLRYNERVRIDGAPVGDAALCAAYARVEGARGHTPLTPF 134 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E+GTL+A+ +F +A LD +LEVGLGGRLDA N DAD A+VTSI +DH ++LGP RESI Sbjct: 135 EFGTLAAMCVFAEADLDAAVLEVGLGGRLDAVNAFDADCAIVTSIGIDHVEYLGPTRESI 194 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-WAFSDAHG 243 EK+G+FR+ +PAI +PE P+TIA A+ GA L + G ++ D W S G Sbjct: 195 AVEKSGVFRAGRPAICADPEPPATIAQEARRLGARLLQSGRDYRVRRDPGDTWTLSRRSG 254 Query: 244 TLENLPLPL----VPQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVSE-- 295 L LPLP V NA L AL A L V I G+ L GRFQ Sbjct: 255 ELGGLPLPALAGDVQLHNAGACLMALETLARTLPVDAAQIHRGLRQVQLIGRFQRWRRHP 314 Query: 296 -SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 +P V+ DVAHNPHAA+ L + P GR LAV ML DKDIAGT L+ VD W+ Sbjct: 315 GAPEVLLDVAHNPHAAQRLALTLTQHPVPGRTLAVFAMLRDKDIAGTAQALRDGVDAWFV 374 Query: 355 APLEGPRGATAEQLLEHLGNGKSFDSV------AQAWDAAMADAKAEDTVLVCGSFHTVA 408 A + RGA+A + L + +V A+ A+A A +D VLVCGSF TVA Sbjct: 375 AGIAERRGASAADMAAALDAAQVQRTVHLSASPLDAYRDALASAGPDDRVLVCGSFSTVA 434 Query: 409 HVMEVIDARRSGG 421 V+ ++A + G Sbjct: 435 AVLRELEAEATAG 447 >UniRef50_Q15VG0 FolC bifunctional protein n=1 Tax=Pseudoalteromonas atlantica T6c RepID=Q15VG0_PSEA6 Length = 426 Score = 338 bits (868), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 179/414 (43%), Positives = 254/414 (61%), Gaps = 4/414 (0%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 I+ + A L WL +L LH K I++GLERV+ V +L + V TVAGTNGKGT Sbjct: 7 IQASSFEAWSLNEWLDHLSALHPKNIEMGLERVNKVFEQLNISFSKQTVVTVAGTNGKGT 66 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 TC LE +AAG +VGVYSSPHL++YTERVR+ G + E AH +F +E ARGDI LT Sbjct: 67 TCAFLEQACLAAGKRVGVYSSPHLIQYTERVRINGIDGSEQAHCRAFQAVERARGDIPLT 126 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+GTL+ L L A +D+ +LEVGLGGRLDA N+V D+AV+TSI LDH D+LG +E Sbjct: 127 YFEFGTLAGLKLVHDANVDIALLEVGLGGRLDAVNVVSPDIAVITSIDLDHQDFLGDTKE 186 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 + EKAGI R P +VGEP + D + AL + V+++Y + D +S+ Sbjct: 187 LVAAEKAGIMRDNIPVVVGEPVKYQALLDAVSQHSALASWQHVDFDYQLADDYMVWSNHQ 246 Query: 243 GTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 + LP+P +P N +T L ++ L++SE + + I LPGR Q + SP ++ D Sbjct: 247 LSYAQLPIPHIPAQNVSTGLQVIQLLKLDLSEGDLANVITDTRLPGRCQYIGYSPAIMVD 306 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 VAHNPHA YL +++ L + R+ V+GML DKDI +LA ++ W L+ PRG Sbjct: 307 VAHNPHATGYLLSQIRKLDYD-RLYLVVGMLKDKDIRSSLADFSNLNAHWMLGGLDVPRG 365 Query: 363 ATA---EQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 A A + +L+ F +V QA++ A A A+ +D ++V GSF TV+ ++++ Sbjct: 366 AAAADIKSVLDEQQKVLEFSTVCQAFEKAKALAQEQDLIVVFGSFFTVSDILKL 419 >UniRef50_Q3JCB5 Folylpolyglutamate synthetase n=3 Tax=Gammaproteobacteria RepID=Q3JCB5_NITOC Length = 432 Score = 338 bits (867), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 193/412 (46%), Positives = 266/412 (64%), Gaps = 10/412 (2%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCRTLES 69 S L+ WL + E H +D L R S V R+ VL PF + T+AGTNGKG+T LE+ Sbjct: 5 SRLSDWLRWQETAHWPRVDPSLIRASAVLQRM-VLSTPPFPIVTIAGTNGKGSTVALLEA 63 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 IL+AAGY+VG Y+SPHL+RY ER+++QG+ + + SFA I++AR +ISLTYFE+GTL Sbjct: 64 ILLAAGYRVGSYTSPHLLRYNERIKIQGEAVSDDIICQSFARIDAARHEISLTYFEFGTL 123 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +A+ +F QA LD+ +LEVGLGGRLDA N +DADVAV+T++ +DH ++LGPDRESIG EKA Sbjct: 124 AAIDIFHQAGLDIALLEVGLGGRLDAVNALDADVAVITTVDIDHINFLGPDRESIGFEKA 183 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 GIFRS +PAI G+PE P ++ A+E L R G +++Y + W++ +LP Sbjct: 184 GIFRSHRPAICGDPEPPESVLAHAKESSVPLYRIGRDFHYQMAGEGWSWWSNGSHYADLP 243 Query: 250 LPLV----PQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 P + N A AL AL+ A+ L VSE AIRDG+++ LPGRFQ + IFDV Sbjct: 244 HPALQGACQYQNGAAALMALKLMAARLPVSETAIRDGLSAVRLPGRFQCLPGEMERIFDV 303 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 AHN A +L + P GR AV+GML DKD+AG ++ L++ + W+ L RG Sbjct: 304 AHNLQGARWLARSLTDRPCGGRTYAVLGMLADKDVAGVVSVLENAIHGWFVGGLAVDRGL 363 Query: 364 TAEQLLEHLGNGKS--FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 + + L E +G+ + SVA+A+ AA+ A+ D VL GSFHTV VM + Sbjct: 364 SGQALAERMGHLTPAIYQSVAEAYRAALEAAQPGDRVLAFGSFHTVEAVMRL 415 >UniRef50_Q3IF42 Bifunctional: folylpolyglutamate synthase; dihydrofolate synthase n=3 Tax=Alteromonadales RepID=Q3IF42_PSEHT Length = 421 Score = 337 bits (865), Expect = 4e-91, Method: Compositional matrix adjust. Identities = 180/414 (43%), Positives = 252/414 (60%), Gaps = 8/414 (1%) Query: 2 IIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 + K P +S L WL YLE++H + I +GLERV+ VA +G+L + + +AGTNGKG Sbjct: 1 MTKTIPSQSSSLDDWLFYLESVHPENIAMGLERVASVANNIGLLNTSSKIILIAGTNGKG 60 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL 121 TT R LES+L+A G VG Y+SPHL Y ERVRV GQEL + H +F +E R D +L Sbjct: 61 TTARCLESLLLAQGLSVGTYASPHLTHYNERVRVNGQELSDQYHVDAFHLLEQGRKDTAL 120 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 TYFEYGTL+AL +FK+ ++D V+LEVGLGGR DATNIV +V+T+I LDH ++LG R Sbjct: 121 TYFEYGTLAALAIFKRCEVDYVLLEVGLGGRYDATNIVTPFASVITTIDLDHKEYLGDTR 180 Query: 182 ESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 E + +KAGIFR PAI+G+ +P T+ D E A + G ++ + +++ Sbjct: 181 ELVAYDKAGIFRENTPAIIGDLNIPHTMTDYGDEINAKMVLSGSDFIFKEHADTFSWQYQ 240 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 LE L P +P NAATAL L L SE+ I+ +A+ ++ GRF+ +S+ P V Sbjct: 241 QYNLE-LAKPAIPSQNAATALTTLSVLNLLPSESVIKACLANLVVEGRFEQLSDQPLVYT 299 Query: 302 DVAHNPHAAEYLTGRMKALPKNG-RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHNP +A YL ++ + G ++ A++ ML DKD AG L + +VD W A L GP Sbjct: 300 DVAHNPESARYLASKLLSYKDKGFKIHALVAMLADKDKAGVLKEVSHLVDQWSLASLNGP 359 Query: 361 RGATAEQL------LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 RG +A L + H S++SVA A D + + + ++V GSF TVA Sbjct: 360 RGDSASNLQNALQSIPHNDIKHSYNSVAAALDVILPTQQNDTVLIVFGSFFTVA 413 >UniRef50_Q604P6 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Methylococcus capsulatus RepID=Q604P6_METCA Length = 431 Score = 337 bits (865), Expect = 4e-91, Method: Compositional matrix adjust. Identities = 187/417 (44%), Positives = 254/417 (60%), Gaps = 12/417 (2%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 S L WLS+ E LH + IDLGLERV V L + PF TV GTNGKG+ L++I Sbjct: 4 STLGEWLSWQETLHPQAIDLGLERVRRVYRALNPAQDRPFTITVGGTNGKGSCVAALDTI 63 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L AGY+VG Y+SPH++RY ER+ + G + ++A ASF IE+ RGD +L++FE+GTL+ Sbjct: 64 LRRAGYRVGAYTSPHILRYNERICIDGTPVDDAAICASFERIEAVRGDTTLSFFEFGTLA 123 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ +F++A+LDV ILEVGLGGRLDA NIVDAD A+V SI +DH +WLG RE+IG EKAG Sbjct: 124 AMDIFRRAELDVQILEVGLGGRLDAVNIVDADAALVASIGIDHEEWLGLTREAIGLEKAG 183 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 IFR +P I+G+P+ P+T+ A+ GA L +G ++++ + W + T LP Sbjct: 184 IFRPARPCILGDPDAPATVLRHAEAIGADLLMQGRDFSFRRENDGWTWYGRGETHAALPE 243 Query: 251 PLV----PQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 P + N A L + A L V E A+R G+AS LPGRFQI P V+ DVA Sbjct: 244 PCLRGDHQYFNMAAVLQVIEAIRPRLPVPEAAVRAGLASVHLPGRFQIQEGEPTVLLDVA 303 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNPHA L ++ + V AV M+ DKDI G + ++ +VDDWY APL+ PR AT Sbjct: 304 HNPHAVRVLAEFLRQFKRGRPVHAVFAMMRDKDIRGVVECIRDLVDDWYLAPLQLPRAAT 363 Query: 365 AEQLL---EHLGNG---KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 E LL LG + F A+ + +A+ + +LV GSF VA + I+ Sbjct: 364 PEILLPVFSALGISQVQQGFADAAEVFARVRRNAENDSIILVFGSFFLVAEYLARIE 420 >UniRef50_C6P114 FolC bifunctional protein n=1 Tax=Sideroxydans lithotrophicus ES-1 RepID=C6P114_9PROT Length = 456 Score = 334 bits (857), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 203/450 (45%), Positives = 250/450 (55%), Gaps = 49/450 (10%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 S LA WLSYLE+LH KTI LGLERV V +L L+PA V V GTNGKG+ C LESI Sbjct: 3 STLADWLSYLESLHPKTIALGLERVEQVRRKLN-LQPAFPVIIVGGTNGKGSVCAMLESI 61 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L AAGYKVG Y+SPHL+ Y ERVR+ Q+ ++ ASFAEIE ARGDISLTYFE+GTL+ Sbjct: 62 LHAAGYKVGCYTSPHLLEYNERVRIAKQQASDAELCASFAEIEQARGDISLTYFEFGTLA 121 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ F Q+DV +LEVGLGGRLDA N+ DADVAVV S+ +DH D+LG RE I EKAG Sbjct: 122 AMQCFISHQVDVAVLEVGLGGRLDAVNVFDADVAVVASVDIDHVDYLGDTREKIAFEKAG 181 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD----------------- 233 IFR + AI + ++P + AQ A L G E+ + + Sbjct: 182 IFRQGRVAICADGDVPQALRQHAQAVAAELWCIGSEFGFQLPSPAGGGEGGGEAHVINVG 241 Query: 234 ------------------HDWAFSDAHGTLENLPLPLVPQP----NAATALAALRA--SG 269 W F GT +LP P + NA+ LA L A Sbjct: 242 QPLSLALSRSREREQKPMGQWNFYSKVGTRSSLPFPALRGAFQLHNASAVLAVLDALKDK 301 Query: 270 LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAV 329 L VS A+R G+ L GRFQ V P++I DVAHNPHAA L + ALP + AV Sbjct: 302 LPVSMEAVRRGLVEVQLAGRFQFVPGLPQLILDVAHNPHAARSLAQNLAALPP-AKTFAV 360 Query: 330 IGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL------GNGKSFDSVAQ 383 ML DKD+ G + L +D W A + PRGATA +L++ L G + S+A Sbjct: 361 FAMLKDKDMTGVVEALDGQIDVWLVAGITAPRGATAAELVQVLQDVQVRGEIQPCASIAD 420 Query: 384 AWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 A A A D + GSF+TVA VM V Sbjct: 421 AMHEASNRAGENDRIAAFGSFYTVAEVMRV 450 >UniRef50_A8PMD7 FolC bifunctional protein n=1 Tax=Rickettsiella grylli RepID=A8PMD7_9COXI Length = 430 Score = 334 bits (857), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 176/412 (42%), Positives = 248/412 (60%), Gaps = 9/412 (2%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+ WLSY+E LH ++ GLER+S VA L +L + TVAGTNGKG+ L +IL Sbjct: 15 LSDWLSYIETLHPHRMEFGLERISHVAENLNLLHFDCPIVTVAGTNGKGSNVGLLAAILS 74 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AGY+VG Y+SPHL Y ER+RV Q + + +F ++E R SLTYFEYGTL+AL Sbjct: 75 VAGYRVGTYTSPHLRHYHERIRVGSQCISDQDLCHAFFQVEKKRLGTSLTYFEYGTLAAL 134 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 + FKQ LD++ILEVGLGGRLDA N VDAD++++++IA+DHT WLG RE IG EKA I Sbjct: 135 YYFKQVPLDLIILEVGLGGRLDAVNCVDADLSIISTIAIDHTQWLGKTREKIGLEKAAIM 194 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 R+ +P + G+ P+++ + A+ + L R GVE++Y + W++ +L +LPLP Sbjct: 195 RAYRPCVCGDFSPPTSVLNTAKSLNSPLYRLGVEFDYKMQHSSWSWQSRKRSLHHLPLPT 254 Query: 253 VPQPNAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPR-VIFDVAHNPHA 309 + NAAT L A L + ++ AI++G+ +PGRF I+ ++ R +I DVAHNP Sbjct: 255 IDLQNAATVLQAVELLSERFTIASFAIQEGLKRVFVPGRFHIIEKNARQIIVDVAHNPAG 314 Query: 310 AEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLL 369 L+ R+ P G A+ GM+ DKDI T L + VD WY L RGA A QL Sbjct: 315 GVCLSKRLANTPCLGETYALAGMMADKDITNTFRPLSNHVDYWYLCDLTEHRGAKATQLK 374 Query: 370 EHLGNGK------SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + L + K F S A+ A + + D +L+ GSFHT A + ++ Sbjct: 375 QSLLDLKVKQSILEFSSPEFAFQRAFSQLRKNDRLLIFGSFHTAAAIYHYLE 426 >UniRef50_Q1N6P7 Folylpolyglutamate synthetase n=1 Tax=Bermanella marisrubri RepID=Q1N6P7_9GAMM Length = 422 Score = 334 bits (856), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 185/413 (44%), Positives = 255/413 (61%), Gaps = 20/413 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WL YLE+ H K IDLGL+RV VA RL ++KPA +V VAGTNGKGTT T + Sbjct: 5 LDQWLQYLESAHPKDIDLGLDRVRAVAERLDLIKPAKYVVLVAGTNGKGTTVATCGELFR 64 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 +G+ VGV++SPH+ +Y ERV + G+++ ++ SF IES RGDISLTYFE LSAL Sbjct: 65 QSGFSVGVFTSPHITKYNERVSINGKQVSDAQLIDSFEAIESKRGDISLTYFEVSALSAL 124 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +LFKQA ++ +LE+GLGGRLDA N+VD DV++VTSI LDH DWLG + IG EKAG++ Sbjct: 125 YLFKQANVEAAVLEIGLGGRLDAVNLVDPDVSIVTSIGLDHQDWLGDTLDKIGYEKAGVY 184 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH---DWAFSDAHG---TLE 246 R KPAI G+ PS + A E A L + ++++ + + DW +A G Sbjct: 185 RQSKPAICGQVNPPSGLLAHANEIDAKLLIKHQDFHHQLNEQGGFDWFGVNASGERIVFN 244 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS------ESPRVI 300 +LPLP VP NA TAL A+ +E + +R + + + GR Q +S + Sbjct: 245 DLPLPKVPIENACTALQAMMMLPIEWAIEDVRLALQNVFVEGRLQAFCYQGSSGQSVSGM 304 Query: 301 FDVAHNPHAAEYLTGRMKALPK-NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 DV HNP AAE+L ++ +P+ GRV AV+ ML DK+ + LK VD W A L+G Sbjct: 305 LDVGHNPQAAEFL---LQYIPETKGRVFAVLAMLQDKNPNDVVTALKDRVDQWCFAGLQG 361 Query: 360 PRGATAEQLL---EHLGNG-KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 RG TA++L+ +HL +G + F SV+QA + M + +D V+V GSF TV+ Sbjct: 362 YRGQTAQELMSRIDHLPHGSRDFHSVSQAMECVMEEVTCDDYVVVLGSFLTVS 414 >UniRef50_A6GNX1 FolC bifunctional protein n=1 Tax=Limnobacter sp. MED105 RepID=A6GNX1_9BURK Length = 468 Score = 331 bits (848), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 190/450 (42%), Positives = 252/450 (56%), Gaps = 39/450 (8%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P A + L WL+YLE++HSK ID+GL+R+ +V + VFTVAGTNGKG+TC Sbjct: 16 PNADASLNDWLAYLESIHSKPIDMGLDRLKVVQQHMNFTLKG-VVFTVAGTNGKGSTCAM 74 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR--GDISLTYF 124 LESIL+ AGYKVG+Y+SPHL+R+TER R+ G+E+ ES ++F ++E R ISLTYF Sbjct: 75 LESILIQAGYKVGMYTSPHLIRFTERARINGEEVSESELISAFEKVEQTRVATGISLTYF 134 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E+ TL+ +F + L+ VILEVGLGGRLDA NI DAD A+ TS+ +DH +LGPDRESI Sbjct: 135 EFTTLAVALVFSRLDLEAVILEVGLGGRLDAVNIFDADCAICTSVDIDHQAFLGPDRESI 194 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 GREKAGIFR KPAIVG+P+ P ++ D A GA L ++NYS WA+ Sbjct: 195 GREKAGIFRPGKPAIVGDPKPPQSVIDHANSIGADLWLFSRDYNYSGDKQQWAYGGRSMR 254 Query: 245 LENLPLPLVPQPNAATALAALRASG------LEVSENAIRDGIASAILPGRFQIVSESPR 298 L P + N +A A+ L V +IR G PGRFQ++ P Sbjct: 255 RAALAYPALRGTNQLLNASAALAALESVRDRLPVPAQSIRQGFLLVEWPGRFQVLPGQPT 314 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 V+ DV HNPHAA +L + + + GML DKD + LK VD W+ PLE Sbjct: 315 VVLDVGHNPHAAAHLRESLDNMGFFPYTHCIFGMLADKDAVEVVKALKDRVDHWHLVPLE 374 Query: 359 GPRGATAEQLLEHL------------------------------GNGKSFDSVAQAWDAA 388 G RG + EQL + L + +S++SV QA+ Sbjct: 375 GDRGRSTEQLKQQLELAGVDAGAFDWVANSQALAKGGIAKQPPEKSVQSYESVGQAYAVV 434 Query: 389 MADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 + D +LV GSF VA M+ +A R Sbjct: 435 TSAVPPNDRILVFGSFLVVAQAMQAKEALR 464 >UniRef50_C6MBR5 FolC bifunctional protein n=1 Tax=Nitrosomonas sp. AL212 RepID=C6MBR5_9PROT Length = 432 Score = 327 bits (837), Expect = 6e-88, Method: Compositional matrix adjust. Identities = 173/419 (41%), Positives = 245/419 (58%), Gaps = 16/419 (3%) Query: 16 WLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 WLSY E H +TI+LGL+R++L+ + L L P + V GTNGKG+ C LESIL AG Sbjct: 14 WLSYFEAFHPQTIELGLDRINLIRSELA-LHPQFPIIIVGGTNGKGSVCAMLESILYCAG 72 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSALW 133 Y+VG Y+SPHL+ Y ER+R+ + + + +F +I SA DISLTYFE GTL+A++ Sbjct: 73 YEVGCYTSPHLLHYNERIRISKKNIDDQRLCNAFMQIYSACKVRDISLTYFEVGTLAAMY 132 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F QA ++ +LEVGLGGRLDA NI DAD +++TS+ LDH D+LG RE IG EKA IFR Sbjct: 133 CFVQAGVNAAVLEVGLGGRLDAVNIFDADCSILTSVDLDHIDYLGDTREKIGFEKAAIFR 192 Query: 194 SEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV 253 KPAI E ++P ++ A+ A+L R + + + W F +LP P + Sbjct: 193 KNKPAICAEIDLPQSVIQQAENNDAILYRINKHFGFLKQEMHWDFWGPRNKRYSLPFPAL 252 Query: 254 ----PQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNP 307 NA+T LAAL L VS + +R G+ A++ GRFQ+VS P +I DVAHNP Sbjct: 253 RGEKQLQNASTCLAALDTLEETLPVSMSNVRQGLIEAVISGRFQVVSTQPFIILDVAHNP 312 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQ 367 AA L+ ++A G+ A++ ML DKDI G + LK+ +D W+ + ++ R A A+ Sbjct: 313 GAAMVLSQNLRATRPTGQTFAIMAMLQDKDIRGVIQALKNDMDYWFVSSVDASRAAAADY 372 Query: 368 LLEHLGNG-------KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 L+ L + F A+ A A D + V GSF+TV V+ ++ +S Sbjct: 373 LINELYEAEVANDRIRKFSDTISAFVFACEQAGKNDRICVFGSFYTVGDVLRYLNTHQS 431 >UniRef50_Q2BMN3 Folylpolyglutamate synthase n=1 Tax=Neptuniibacter caesariensis RepID=Q2BMN3_9GAMM Length = 419 Score = 326 bits (835), Expect = 1e-87, Method: Compositional matrix adjust. Identities = 182/408 (44%), Positives = 249/408 (61%), Gaps = 11/408 (2%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WLS++E H+ IDLGL+RVS VA L + + V TVAGTNGKG+T L SI + Sbjct: 7 LTQWLSWMEQCHTAEIDLGLDRVSRVADELQLDLSSSTVVTVAGTNGKGSTVSYLSSIYL 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AGY VG Y+SPH +RY ERVR+ G E + +F I+ ARG I LTYFE+GTL+AL Sbjct: 67 QAGYSVGAYTSPHFLRYNERVRLNGLEATDEQLCDAFERIDQARGQIPLTYFEFGTLAAL 126 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +F + D+V+LEVGLGGRLDA NI+DADV+VVT++++DH DWLG DRE IG EK+GIF Sbjct: 127 IIFADTKPDLVLLEVGLGGRLDAVNIIDADVSVVTTVSIDHVDWLGDDREFIGHEKSGIF 186 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS--DAHGT---LEN 247 R++KPAI G+ P ++A A + GA L + ++++ T W + +A G+ + + Sbjct: 187 RADKPAICGDLNPPVSVAKYAADIGAELYQADQQFSFEKTKKGWHWKGLNADGSEQIIND 246 Query: 248 LPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDVAHN 306 LPLP +P NA+TA+ + L VS + I+ G+ +A L GR Q + + DVAHN Sbjct: 247 LPLPSLPLQNASTAIQVCQHIPLNVSADQIKTGLQTATLTGRMQKLEVDGVNYWLDVAHN 306 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 P AAE L R+K +PK V ++GML DKD + + VVD Y L PRG A Sbjct: 307 PEAAELLAKRIKDMPK--PVTLLLGMLADKDCQQVIDLITPVVDSIYLTDLNVPRGQKAS 364 Query: 367 QLLEHLGNGK---SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 L L +G D+V A + AE+ V++ GSF TV+ + Sbjct: 365 ALAALLPSGVHALQADTVKSAIEQIKKHTNAEENVIIAGSFFTVSDAL 412 >UniRef50_B4RUR1 Bifunctional folylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Alteromonas macleodii RepID=B4RUR1_ALTMD Length = 443 Score = 320 bits (821), Expect = 5e-86, Method: Compositional matrix adjust. Identities = 187/418 (44%), Positives = 251/418 (60%), Gaps = 25/418 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WLSYLE++H ID+GL+RV VA + + V TVAGTNGKGTTCR LE ++ Sbjct: 28 LGQWLSYLESIHPSAIDMGLDRVKAVAQSMALSLSQSLVITVAGTNGKGTTCRLLEQAML 87 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR----GD-ISLTYFEYG 127 + G V VYSSPHL Y ERVR G+ P + +F +E +R GD I+LTYFE+G Sbjct: 88 SQGKSVAVYSSPHLTDYRERVRYNGELPPANEFVKAFEFVEKSRKETEGDPITLTYFEFG 147 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 TL+A+ + + ++DVVILEVGLGGRLDATNI+ D+A++T+I LDH DWLG RE I RE Sbjct: 148 TLAAMKMMQSWEVDVVILEVGLGGRLDATNIIHPDLAIITTIDLDHQDWLGNTREKIARE 207 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEW------NYSVTDH-DWAFSD 240 KAGI R A+VG+ PS++ DV E A V W +D+ +W++ Sbjct: 208 KAGIMRKNGNAVVGDLFPPSSLYDVVNELQA-----NVRWATQDFVTVVASDYSEWSWKG 262 Query: 241 AHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 + + +LP P +P NA+TALAAL L E +RD I + +PGR + +SESP V+ Sbjct: 263 KNSSYASLPYPKIPLQNASTALAALELLELLPEEQVVRDIIKNTTMPGRQETISESPLVV 322 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHNP A + + + ++ V+GML DK IA TLA L ++ DWY A GP Sbjct: 323 VDVAHNPQATAEMQNWLNRYDVS-KMRIVVGMLKDKSIAETLAPLAALNADWYVASTSGP 381 Query: 361 RGATAEQLLEHLGNG-------KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 RG AE L L N ++F +V A+ A+AD + + +LV GSF TVA V+ Sbjct: 382 RGCEAEVLENALVNAGTTIENIETFQTVTSAYQRALADYQTGELILVFGSFVTVADVL 439 >UniRef50_B5JSE1 FolC bifunctional protein n=1 Tax=gamma proteobacterium HTCC5015 RepID=B5JSE1_9GAMM Length = 427 Score = 318 bits (816), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 182/414 (43%), Positives = 253/414 (61%), Gaps = 17/414 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L +WLS+ LHS +DLGL+R+ V ARL + V TVAGTNGKG+T LESI Sbjct: 8 LQAWLSWQGRLHSSEVDLGLDRIRAVLARLSLDFSQSIVVTVAGTNGKGSTLAFLESIYR 67 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AGY+VG+++SPH + Y ER+R+ G + E A +FA I+S RG+ISLTYFE+ TL+AL Sbjct: 68 QAGYRVGLFTSPHFLHYCERIRIDGDRVSEQAVCDAFAAIDSVRGEISLTYFEFSTLAAL 127 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 WLF + L V++LEVGLGGRLDA+N++DADV +VTS+++DH DWLG +RE IGREKAGI+ Sbjct: 128 WLFARESLAVILLEVGLGGRLDASNVIDADVGIVTSVSIDHRDWLGDNREDIGREKAGIY 187 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 R + AI G+P P ++ +VA KG+ Q RG ++ + D A E+ P Sbjct: 188 RRNRMAISGDPHPPHSLREVASIKGSDWQGRGEQFEVFTSSEDRARWRLQWRGEDFEFPY 247 Query: 253 -------VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 + NAA+AL A LRA V ++ + G+ A LPGR Q++ ++P V+ D Sbjct: 248 PERLTAPIQLDNAASALVAVLGLRAQ-RPVDKSDMDRGLCQAGLPGRLQVIGQNPEVMLD 306 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 VAHN AA+ L G + +V V+GML DK++ T + L+++ WY A + R Sbjct: 307 VAHNEAAAKALFGAVAGRSYE-QVHLVLGMLQDKEVRATASVLEALQPHWYLATPQSERA 365 Query: 363 ATAEQLLEHL-GNGKS----FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 +L L G+ S + SV +A+ AA+ A D V+V GSF TVA VM Sbjct: 366 MDCRELAAMLPGSAASASVCYASVTEAYRAALGRAGENDLVIVTGSFFTVAEVM 419 >UniRef50_Q47XK6 FolC bifunctional protein n=1 Tax=Colwellia psychrerythraea 34H RepID=Q47XK6_COLP3 Length = 437 Score = 316 bits (809), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 177/421 (42%), Positives = 243/421 (57%), Gaps = 18/421 (4%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 Q + L WL YLENLHS IDLGL RV VA RL + V TVAGTNGKGTTC + Sbjct: 10 QDLTNLDQWLYYLENLHSTEIDLGLSRVGKVAERLAINLNFAKVITVAGTNGKGTTCAFI 69 Query: 68 ESILM-----AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 E+ L+ A+ V VYSSPH+ R+ ER+R+ Q++ + A +F IE AR DISL+ Sbjct: 70 ENALLNSKELASPRGVAVYSSPHIERFNERLRINKQDVEDQALINAFKRIEVAREDISLS 129 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 Y+EY TL+AL + +A +ILEVGLGGRLDATNI+DAD+AV+T+I LDH +LG DRE Sbjct: 130 YYEYTTLAALLVLMEAMPSFIILEVGLGGRLDATNIIDADIAVITTIDLDHQSFLGNDRE 189 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQE----KGALLQRRGVEWNYSVTDHDWAF 238 SIG EKAGI R E+ ++G+ P ++ + A E + + R ++ T W + Sbjct: 190 SIGFEKAGIMRQEQDIVIGDTNAPKSVINHANELHKNQVNRIFLRDQDFIVQNTQPHWNW 249 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES-- 296 L L P +P+ N ATAL L L ++ + + + IA + GR +++ + Sbjct: 250 KTKQTQLTELKAPHIPRDNVATALMVLEKLNLTLTPDFVNEVIAKTKVAGRTELIKQKGL 309 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNG---RVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 VI DV HNP A YL G +K + + + AV+ ML DKDI+ +L LK +D WY Sbjct: 310 CDVILDVGHNPQATRYLAGYLKQIKEQANYQNIYAVVAMLGDKDISASLESLKDDIDFWY 369 Query: 354 CAPLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 L PR AT E + L + FD+V +A+ A A + D +LV GSF TV+ Sbjct: 370 TGALSVPRAATKETMASKLALFTNSVNCFDNVDEAFRMANKQANSSDLILVFGSFFTVSK 429 Query: 410 V 410 + Sbjct: 430 I 430 >UniRef50_Q6FEE4 Bifunctional protein n=18 Tax=Acinetobacter RepID=Q6FEE4_ACIAD Length = 428 Score = 311 bits (797), Expect = 3e-83, Method: Compositional matrix adjust. Identities = 181/421 (42%), Positives = 253/421 (60%), Gaps = 13/421 (3%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P L +WL+Y ++H IDLGLERV VA +LGV + + VFTVAGTNGKG+T T Sbjct: 6 PSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKGSTTTT 65 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD--ISLTYF 124 L SIL GY+VG+Y SPH+ R+ ERV++ GQE + +F +++ R + +SL++F Sbjct: 66 LASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGLSLSFF 125 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E TL+A +F+Q D+ +LEVGLGGRLD N++D DVAV+T+I LDHTDWLG E I Sbjct: 126 EATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGDTIEKI 185 Query: 185 GREKAGIFRSEKPAIVGEPE-MPSTIADVAQEKGALLQRRGVEWNYSVT--DHDWAFSDA 241 EKAGI RS P I G + +P IAD A + A L G ++ Y V W F+ + Sbjct: 186 AFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSWNFASS 245 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRF-QIVSESPRVI 300 GT LPL + N +TA+AAL SG++VS+ AI GI A L GRF Q + ++ V+ Sbjct: 246 -GTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKNKAVV 304 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGR----VLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 FD HN H ++L +++ + + V+AV ML DKDI + LK V W A Sbjct: 305 FDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHWKVAA 364 Query: 357 LEGPRGATAEQLLEHLGN--GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 L PR A QLL+ L + +DS+ +A+ A+ +++ +LVCGSFHT+ V E + Sbjct: 365 LSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAVWEYL 424 Query: 415 D 415 + Sbjct: 425 E 425 >UniRef50_UPI0000E0E8A2 FolC bifunctional protein n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=UPI0000E0E8A2 Length = 425 Score = 310 bits (793), Expect = 9e-83, Method: Compositional matrix adjust. Identities = 181/417 (43%), Positives = 245/417 (58%), Gaps = 16/417 (3%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 T A + L WL++LE++H ID+GL+RV V RL + V TVAGTNGKGTTC Sbjct: 2 TLTADASLMEWLTHLESIHPVGIDMGLDRVQAVYQRLNLDWSGVTVITVAGTNGKGTTCA 61 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 +E+ + GY+VGVYSSPH+ Y ERVR+ Q L ++AHT +FA IE+ARG+ISLTYFE Sbjct: 62 FIEAAAIQCGYEVGVYSSPHINTYNERVRINQQLLDDTAHTQAFAAIEAARGNISLTYFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 +GTL+ LWL Q LDV +LEVGLGGRLDA N+VD D+AV+TSI LDH +LG R I Sbjct: 122 FGTLAGLWLLHQQALDVAVLEVGLGGRLDAINVVDPDIAVITSIGLDHQAFLGDTRALIA 181 Query: 186 REKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 +EKAGI R+ KP I+GEPE P T+ + A Q ++ Y + +H+ T Sbjct: 182 QEKAGIMRAGKPVIIGEPEPPHTLREAVVSYAADAQWVSQDFAYHI-EHNLFHFKMGSTQ 240 Query: 246 ENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIV------SESPRV 299 +LPLP +P PNAATA+A + VS + A L GR ++ SE+P + Sbjct: 241 LSLPLPHIPFPNAATAMAVVHQLAWPVSASQWAYCAAHTRLNGRLTVLTEHAFGSEAPVI 300 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 + D AHN A+EYL + L RV AV G++ DKD AG A L +V WY ++ Sbjct: 301 MLDAAHNIQASEYLATHIAHLAPR-RVFAVCGIMQDKDWAGVCAPLVPLVSHWYPCDVQI 359 Query: 360 PRGATAEQLLEHLGNGKSFD-----SVAQAWDA---AMADAKAEDTVLVCGSFHTVA 408 R A + L N + + +V ++ A+ A +D VL+ GSF T++ Sbjct: 360 ERAAKGSDIAACLVNSLAINKTQVTAVNTPYEGVVNAIKTATNQDLVLIFGSFFTLS 416 >UniRef50_B8GQE7 FolC bifunctional protein n=1 Tax=Thioalkalivibrio sp. HL-EbGR7 RepID=B8GQE7_THISH Length = 386 Score = 308 bits (788), Expect = 4e-82, Method: Compositional matrix adjust. Identities = 165/310 (53%), Positives = 212/310 (68%), Gaps = 9/310 (2%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WL++ E LH + IDLGLERV+ VAARL +L PA V TVAGTNGKG+T LE+I Sbjct: 6 LDQWLAWQETLHPRAIDLGLERVARVAARLDLLTPACPVITVAGTNGKGSTVAMLEAIYR 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AAGY+V Y+SPHL+RY ER+R+ G +++ +FA +++ARG+ +L+YFE+GTL+AL Sbjct: 66 AAGYRVCAYTSPHLLRYNERIRIHGSLADDASLCRAFAAVDAARGEDTLSYFEFGTLAAL 125 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 WLF++A D+++LEVGLGGRLDA NIVD DV+VVTS+ +DH WLGPDRESIG EKAGIF Sbjct: 126 WLFREAGADILVLEVGLGGRLDAVNIVDPDVSVVTSVGIDHEQWLGPDRESIGAEKAGIF 185 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT---DHDWAFSDAHGTLENLP 249 R+++PA+ G+P P++IA A GA L G +++SV DH L++LP Sbjct: 186 RAQRPAVCGDPTPPASIAGTAARLGAKLYAAGQAFSWSVDASGDHWQWRGPGDVVLDDLP 245 Query: 250 LPLVPQP----NAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 P +P NAATAL A L A V AI G+AS LPGRFQ + P VI DV Sbjct: 246 PPALPGAIQFNNAATALTAVTLLAPRCPVPREAICRGLASVSLPGRFQRLRSDPAVILDV 305 Query: 304 AHNPHAAEYL 313 AHNP AE L Sbjct: 306 AHNPQGAEVL 315 >UniRef50_A7C245 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Beggiatoa sp. PS RepID=A7C245_9GAMM Length = 441 Score = 306 bits (784), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 175/432 (40%), Positives = 248/432 (57%), Gaps = 30/432 (6%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + L WL++ +LH I+LGL+RV+ VA RL +L P + TVAGTNGKG++ L+SI Sbjct: 4 TTLKQWLNWQSSLHPTEIELGLDRVTTVAKRLNLLPPPFPIITVAGTNGKGSSIILLDSI 63 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L AGY VG + SPHL+RY ER+ V G E + +F IE RG+ISLTYFE+ TL+ Sbjct: 64 LSTAGYHVGRFMSPHLLRYNERICVGGVEASDVQICHTFELIEKVRGEISLTYFEFSTLA 123 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ +F+ Q+D+ +LEVGLGGRLDA NI DAD+ +VT+I +DHTDWLG DRESIG EKAG Sbjct: 124 AMLIFQHNQVDIAVLEVGLGGRLDAVNIFDADITLVTAIDIDHTDWLGNDRESIGFEKAG 183 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNY--------------------- 229 IFR+ PA+ + P ++ + A+ L +++Y Sbjct: 184 IFRAHCPAVCSDTNPPQSLINYAEHLKTPLYYLNHDFSYFKKADKNPSWQMKCHLKSLPL 243 Query: 230 -SVTDHDWAFSDAHGTLENLPLPLVPQPNAATALA--ALRASGLEVSENAIRDGIASAIL 286 + + + +H L NL Q NAA L AL + V + AI G+ IL Sbjct: 244 SPINKKKYQYIFSHLPLPNLVGDFQLQ-NAAGVLMVLALLSDRFPVLDAAIHQGLTHLIL 302 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 PGRFQI+ I DV HNP A+ L ++ P G AV+GML+DKDI L ++ Sbjct: 303 PGRFQILKGRVTRILDVTHNPLGAKVLAKLLEQHPCEGETHAVVGMLNDKDITSVLTIMQ 362 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHLGNG-----KSFDSVAQAWDAAMADAKAEDTVLVC 401 + +D W+ APL+ R A + L+++L S+ S+ +A++ +A A D ++V Sbjct: 363 NSIDHWHVAPLDTARSADIDVLIDNLTTLGITLIYSYSSIQEAYEEWLAYAPDGDRIVVF 422 Query: 402 GSFHTVAHVMEV 413 GSF+ VA +EV Sbjct: 423 GSFYAVAEALEV 434 >UniRef50_C6WVE3 FolC bifunctional protein n=1 Tax=Methylotenera mobilis JLW8 RepID=C6WVE3_METML Length = 458 Score = 306 bits (783), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 186/436 (42%), Positives = 259/436 (59%), Gaps = 34/436 (7%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L++WL+Y+E LH I++GL R+ VA RL LKP + TVAGTNGKG+TC L I Sbjct: 14 LSAWLTYIEQLHPSAIEMGLGRIKTVADRLA-LKPTFKIITVAGTNGKGSTCTMLSQIYQ 72 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR-------GDISLTYFE 125 AGY+VG Y+SPH++RY ERV+V GQE +++ A+FA +E+AR ISLTYFE Sbjct: 73 HAGYRVGCYTSPHILRYNERVQVNGQEASDASLCAAFAAVEAARLGTANQSFAISLTYFE 132 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 GTL+A+W F Q +DV +LE+GLGGRLDA N + D +VT++ LDH D LG RE IG Sbjct: 133 IGTLAAVWHFVQTGVDVAVLEIGLGGRLDAVNAFEPDCTIVTNVDLDHQDLLGDTRELIG 192 Query: 186 REKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 EKAG++R+ PAI G+ PST+ A+E A L+ E+ Y + D W + + + Sbjct: 193 YEKAGVYRASIPAICGDINPPSTLIAYAKEVKADLKCVQHEFGYELADAGWYYLNNQQRV 252 Query: 246 ENLPLPLVP----QPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 +LP+P + NAA A+ A+ A S L V+ +I + L GRF P + Sbjct: 253 YHLPIPALKGQYQLTNAACAITAVTALQSVLPVALESIVKAMQEIKLMGRFYTDERFPWL 312 Query: 300 IFDVAHNPHAAEYLTGRMKALP-----KNG---RVLAVIGMLHDKDIAGTLAWLKSVVDD 351 IFDVAHNPHAA L +K+L K+G R+L+V ML DKDI G + LK VD Sbjct: 313 IFDVAHNPHAAVALAENLKSLKSLTSNKSGEPVRILSVFSMLADKDIKGVVEILKGEVDT 372 Query: 352 WYCAPLEGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKA------EDTVL 399 WY AP+E RG + + L+ + + K+F S+A A+ A D ++ D ++ Sbjct: 373 WYVAPIEHARGTSVKALVTAIHEVIPDASVKTFASLADAYTQAYLDRESCIEQHENDKIV 432 Query: 400 VCGSFHTVAHVMEVID 415 GSF TV+ VM+ ++ Sbjct: 433 AFGSFFTVSSVMQYLN 448 >UniRef50_C6N083 FolC bifunctional protein n=2 Tax=Legionella RepID=C6N083_9GAMM Length = 429 Score = 305 bits (781), Expect = 2e-81, Method: Compositional matrix adjust. Identities = 169/413 (40%), Positives = 238/413 (57%), Gaps = 7/413 (1%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 LA WLS LE +++ I LGL R+ VA +L + V TVAGTNGKG+T LE I Sbjct: 10 LAKWLSALETRNTQEIQLGLTRIQEVAQKLKLQNTECRVITVAGTNGKGSTVTALEHIYH 69 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AGYKVG Y+SPHL+++ ER+RV + + +F IE+ARG I LTYFE TL+AL Sbjct: 70 TAGYKVGTYTSPHLIQFNERIRVGLTPISDHDLCMAFRTIEAARGQIILTYFEMTTLAAL 129 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 FKQA LD++ILEVGLGGRLDATN++DAD++++T+I DH D+LG ++IG EKAGI Sbjct: 130 LYFKQACLDLIILEVGLGGRLDATNVIDADLSIITTIDFDHQDFLGTTLDAIGYEKAGIL 189 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 R KP I + P+TI DVA + E++++ W+ L NLP P Sbjct: 190 RQRKPFIYADVNPPATIVDVASKLFCPTYFFNQEYSFAEQKASWSIYCGDHQLNNLPKPS 249 Query: 253 VPQPNAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 + +AA A+ A L A L V+ ++ + +PGR Q+ +++DV+HN +A Sbjct: 250 IQLKSAAAAIMAVFLLARDLPVAFEQVQAAMRQIFIPGRLQLQKGPVSILYDVSHNAQSA 309 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 + L + +L GR+ AV L DKDI G + LK+ VD WY A L R +A LL Sbjct: 310 KLLADTLYSLDSKGRIHAVFSALKDKDILGLIEPLKNCVDRWYPAQLGVKRAVSANLLLS 369 Query: 371 HLGNGKSFDSVAQ-----AWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 + + + + A++ A+ A+ D ++V GSF TV HV+ RR Sbjct: 370 YFKKAEIYVEICYNNPLLAFETALNQAEPGDLIVVYGSFFTVGHVLAAKPNRR 422 >UniRef50_C1D9J6 FolC n=26 Tax=Neisseriaceae RepID=C1D9J6_LARHH Length = 424 Score = 303 bits (776), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 176/412 (42%), Positives = 235/412 (57%), Gaps = 14/412 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 LA WLS+LE+LH +IDLGLERV V + L+P V TV GTNGKG+ C L IL Sbjct: 7 LAGWLSHLESLHLSSIDLGLERVRQVVDAMP-LRPGFPVITVGGTNGKGSVCAMLTRILA 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 +AGY+VG Y+SPHL+ Y ER+ + + L + A A +E+ RGD+ LTYFE+GTL+A+ Sbjct: 66 SAGYRVGTYTSPHLMVYNERIAIDAESLSDEAIVRGLAAVEAGRGDVPLTYFEFGTLAAM 125 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 W F A++DV ILEVGLGGRLDA N+ + D A V S+ LDH DWLG +RE IG EKAGIF Sbjct: 126 WNFVDAKVDVAILEVGLGGRLDAVNVFEPDCAAVVSVDLDHQDWLGDNREDIGFEKAGIF 185 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH-DWAFSDAHGTLENLPLP 251 R+ KPA+ +P+ P+ + A GA L G ++ ++ TD W F LP P Sbjct: 186 RAGKPALCADPQPPARLVGHAAAIGAPLWLAGRDFGFTRTDPLQWEFWCGQSRRHALPTP 245 Query: 252 LV----PQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 + NAA LA L A L V A+R G+ P RFQ++ P + DV H Sbjct: 246 ALRGNYQMGNAALVLAILEAVRDRLPVGAGAVRRGLLEVEWPARFQVLPGRPVTVLDVGH 305 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGAT 364 NPHA + ++ L R LAV ML DKD+ + K D+W+ AP+ + PR Sbjct: 306 NPHAIRAMVSSLQTLNYAERRLAVFSMLADKDVDSVIELAKDEFDEWWVAPIADSPRAMP 365 Query: 365 AEQLLEHL---GNGKSFDS--VAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 L+ L G + + +A A+ A A D + V GSFHTVA ++ Sbjct: 366 VAGLVARLRAHGVTRIHECADLATAYRQAREQATENDRITVFGSFHTVAAIV 417 >UniRef50_Q2NZP7 Folylpolyglutamate synthase n=19 Tax=Xanthomonadaceae RepID=Q2NZP7_XANOM Length = 432 Score = 302 bits (773), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 190/425 (44%), Positives = 259/425 (60%), Gaps = 22/425 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + L+ WL+Y+E H +I +GLERV VAARL + PA V GTNGKG+T +E+I Sbjct: 5 TTLSEWLAYIEQQHPSSIAMGLERVREVAARLQIAAPAKHAIVVGGTNGKGSTVAFIEAI 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 AAG+K+G Y+SPHL+RY ERVR+ G+E ++ +FA +E+ARGD +LTYFE+GTL+ Sbjct: 65 GRAAGWKIGAYTSPHLLRYNERVRIDGEEASDAQLVDAFAAVEAARGDTALTYFEFGTLA 124 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 ALWLF+ A LD+ +LE+GLGGRLDA NIVDADVAV+T++ +DHTDWLG DRE+IG EKAG Sbjct: 125 ALWLFQSAALDLTVLEIGLGGRLDAVNIVDADVAVITTVDIDHTDWLGEDREAIGTEKAG 184 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-----------HDWAFS 239 I R+ KP ++GE + PS++ A + GA R G ++ + + W + Sbjct: 185 IMRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIEVQHPENPQSDAPQWRWR 244 Query: 240 DAHGTLENLPLPLVPQP----NAATALAALRASGLEVSENAIRDGIASAILPGRFQ-IVS 294 D TLE LP+P + P NAA A+AAL+A +EV A GI +A + GR Q + Sbjct: 245 DVAVTLE-LPMPALHAPVQLANAAAAIAALQALPVEVPAAAWVQGIGNAQVAGRLQRLAV 303 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 + +V+ DV HNP AA L + A G A+ L DKD+ G + + + +D W Sbjct: 304 DGLQVLLDVGHNPQAARALAAALGAQAHAGSTYAIYAALADKDVVGVVEAVAAQIDHWAL 363 Query: 355 APLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 A LEG RG +A+ L L VA A +A +A A D VLV GSFHTVA Sbjct: 364 AGLEGARGQSAQALHARLQGTAAAQALCHRDVASAVEAVLATASPGDRVLVFGSFHTVAD 423 Query: 410 VMEVI 414 + + Sbjct: 424 ALSAL 428 >UniRef50_C5SCQ4 FolC bifunctional protein n=1 Tax=Allochromatium vinosum DSM 180 RepID=C5SCQ4_CHRVI Length = 432 Score = 301 bits (771), Expect = 3e-80, Method: Compositional matrix adjust. Identities = 189/416 (45%), Positives = 249/416 (59%), Gaps = 18/416 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLK---PAPFVFTVAGTNGKGTTCRTLES 69 L WL + +LH +DLGLERV V ARL + P P V TV GTNGKG+T +ES Sbjct: 13 LDDWLDWQSSLHPSRMDLGLERVGAVWARLAPERGRLPCP-VITVGGTNGKGSTVAMIES 71 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 + +AAGY+ GVY+SPHL RY ERVR+ G + + A SF I+ AR ISLTYFE+GTL Sbjct: 72 MALAAGYRCGVYTSPHLCRYNERVRLDGVPVADEALCDSFERIDRAREGISLTYFEFGTL 131 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +AL +F +A+ D+V+LEVGLGGRLDA N++D+DV+VVTSI LDHTDWLG ESI REKA Sbjct: 132 AALDIFARARPDLVVLEVGLGGRLDAVNLIDSDVSVVTSIGLDHTDWLGDSLESIAREKA 191 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 GIFR +PAI+G+ + P T+ A GAL + G E +++ T W ++ G LP Sbjct: 192 GIFRPGRPAIIGQRDAPETLRAEAARIGALALQLGRELDHARTTEGWIWTGPDGQRLALP 251 Query: 250 LP-------LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 +P L A A+ ALR L V NAIR G+ A LPGRFQ++ + I D Sbjct: 252 IPALRGSFQLDNATAAIAAVQALRER-LPVPVNAIRAGLQRARLPGRFQVMPGAVTWILD 310 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 VAHN AAE L ++ GR+ AV+ +L DK+ + ++ V+DWY A E R Sbjct: 311 VAHNGEAAEALAANLRDFACPGRLRAVLAVLADKNPERLVTPIREYVNDWYLAQSEDARA 370 Query: 363 ATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 EQL L +F VA+A AA+A++ D +L+ GSF TV + Sbjct: 371 LPVEQLSARLDGLIGANRRGAFGCVAEAIGAALAESAPGDALLIVGSFTTVGQALR 426 >UniRef50_B3PFP2 Folylpolyglutamate synthetase n=1 Tax=Cellvibrio japonicus Ueda107 RepID=B3PFP2_CELJU Length = 430 Score = 300 bits (768), Expect = 8e-80, Method: Compositional matrix adjust. Identities = 181/418 (43%), Positives = 255/418 (61%), Gaps = 18/418 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 LA+WL +LEN H + IDLGLER+ LVA R+G+L+P V TV GTNGKG+ ++L Sbjct: 6 LAAWLEWLENCHPREIDLGLERIRLVAGRMGLLQPTARVVTVGGTNGKGSCVTATAALLR 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEY 126 AAGY VGVY+SPHL Y ERV + G+ + + A SF I + ISLTYFEY Sbjct: 66 AAGYSVGVYTSPHLRVYNERVTIDGEPVDDQALCNSFERIYACCHANPPAEPISLTYFEY 125 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 GTL+AL +F+ +D ++LEVGLGGRLDA NI+DAD++V+TSI +DH DWLG +RE IG Sbjct: 126 GTLAALDIFRARSVDAMVLEVGLGGRLDAVNILDADISVITSIDIDHKDWLGDNREDIGF 185 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-HDWAFSDAHGTL 245 EKAGI+R+ +PAI + + P + + GA RG ++Y D + W +S + G Sbjct: 186 EKAGIYRAGRPAICADFDPPQRLLQAIIDLGAKGYLRGKHFDYHQEDTNHWRWSGSAGHF 245 Query: 246 ENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR-VIFDVA 304 E+ PLP +P P+ A AL A+ G+ V+ + +A +PGRFQ ++ R VI DVA Sbjct: 246 EHQPLPQLPLPSMAAALEAVTHLGVTVTPASFA-LLAELRVPGRFQHLAWQGRTVILDVA 304 Query: 305 HNPHAAEYLTGRM---KALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 HNP A +L + + RV A + M+ DKD G+LA L++++D W L+ PR Sbjct: 305 HNPAATLHLAKGLSDWRNTNPGARVFAAVAMMSDKDRPGSLANLQALMDGWLLVDLDIPR 364 Query: 362 GATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAE-----DTVLVCGSFHTVAHVMEVI 414 A++EQL ++L + F+ +A A A + D ++V GSF TVA +EV+ Sbjct: 365 AASSEQLRKNLQD-LGFEPLASGKMKACLQALLQVSVQGDLLVVFGSFFTVAAALEVL 421 >UniRef50_A5IBI5 FolC bifunctional protein n=4 Tax=Legionella pneumophila RepID=A5IBI5_LEGPC Length = 428 Score = 299 bits (766), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 163/413 (39%), Positives = 236/413 (57%), Gaps = 7/413 (1%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 TP + L WL++LE +++ I LGL RV VA +L + +P V TVAGTNGKG+T Sbjct: 3 TPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGSTVT 62 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 LE+I +G++VG Y+SPHL+ + ER+R+ + + +F+ IE AR +LTYFE Sbjct: 63 ALETIYHQSGFRVGTYTSPHLLVFNERIRINLTPIQDKDLCKAFSVIEEARYPTNLTYFE 122 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 TL+ALW FKQ LD++ILEVGLGGRLDATNIVD D+A++T+I DH ++LG E IG Sbjct: 123 MATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDLAIITTIDFDHQNFLGDTLELIG 182 Query: 186 REKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 EKAGI R KP I + P ++ +VA + GA G ++ Y W + Sbjct: 183 YEKAGILRKNKPFIYADLSPPKSVVEVALQLGASSYLYGKDYFYQEEADHWEVTCQGKPF 242 Query: 246 ENLPLPLVPQPNAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 E L P + +AA A+ A L + L VS ++ + +PGR Q+ +++DV Sbjct: 243 EQLTRPKIQLRSAAAAVMACHLMQNDLPVSYKNLKKAMELIYIPGRLQLQKGKTDILYDV 302 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 +HNP + L +K + G++ AV L DKD+ G + L+ V+ WY A L R A Sbjct: 303 SHNPQSVRLLADTIKKINVKGQIHAVFSALKDKDLYGLIMPLRDCVNRWYPAQLHNKRAA 362 Query: 364 TAEQLLEHLGNGKSFDSVA-----QAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 + E+LL + F V A++ A+ A +D ++V GSF TV+HVM Sbjct: 363 SQEELLSVFREAEIFLDVCYNDPFTAFEMALKQASDDDLIIVYGSFFTVSHVM 415 >UniRef50_Q31HH1 FolC bifunctional folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Thiomicrospira crunogena XCL-2 RepID=Q31HH1_THICR Length = 425 Score = 296 bits (757), Expect = 1e-78, Method: Compositional matrix adjust. Identities = 169/419 (40%), Positives = 240/419 (57%), Gaps = 16/419 (3%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P + L W+ +L +LH+ IDLG++RV VA + + P+P V +VAGTNGKG++ Sbjct: 3 PTDTTSLTEWIDWLVSLHADEIDLGIDRVKSVAEAMNLASPSPVVISVAGTNGKGSSVAM 62 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 L SI A+GY+VGVY+SPHL+ + ER+RVQGQ + +FA IE+ARG LTYFE+ Sbjct: 63 LSSIYEASGYQVGVYTSPHLLHFNERIRVQGQLADDQQIVQAFAAIEAARGQTKLTYFEF 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 TL+ALW+F Q LDV++LEVGLGGRLDA N+VDAD +++T+I +DH DWLG DR I Sbjct: 123 STLAALWVFAQHALDVILLEVGLGGRLDAVNLVDADASLITAIGVDHEDWLGSDRNQIAV 182 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG--T 244 EKAGI RS KP I + ++P T+ A + L+R E+ Y D W+F D+ Sbjct: 183 EKAGIMRSGKPTICSDNDIPETLISYASQHNVPLKRLAKEFFYQKNDQAWSFLDSEHKPI 242 Query: 245 LENLPLPLVPQ----PNAA--TALAALRASGLEVSENAIRDGIASAILPGRFQ-IVSESP 297 ++L LP + NAA AL S L VS + + G++ PGR Q I + Sbjct: 243 YQDLALPALSGDFQIQNAAGVVALVETLQSDLPVSFDQLSQGLSDVTHPGRLQKIQFDHQ 302 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 + DVAHNP AA+ L +K A+ +L DKD+ + +K + W A L Sbjct: 303 NWLIDVAHNPQAAQVLAHYLKQASIQAN--AIFSVLQDKDVVPMVEAIKPYIKKWSIADL 360 Query: 358 EGPRGATAEQLLE-HLGNGKSFDSVAQAWDAAMADAKAEDT----VLVCGSFHTVAHVM 411 PR + ++L L +G +++ + + + A A T VLV GSF TV+ + Sbjct: 361 AVPRALSVDKLERVLLQSGVPSENIVKCSNISEAVAHNRQTSGNDVLVWGSFFTVSQTL 419 >UniRef50_A1U0X0 FolC bifunctional protein n=3 Tax=Marinobacter RepID=A1U0X0_MARAV Length = 438 Score = 295 bits (756), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 181/422 (42%), Positives = 251/422 (59%), Gaps = 24/422 (5%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P + + WL +LE +H IDLGL+RV +V RL KP + TVAGTNGKGTT Sbjct: 16 PARGASVQEWLHWLEAIHPTEIDLGLDRVLVVLRRLFPRKPQARIITVAGTNGKGTTVTA 75 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 LESIL+AAG G Y SPHL RY ERVR+ GQE+ ++A +F +E+AR ++LTYFE+ Sbjct: 76 LESILLAAGRSTGAYVSPHLFRYNERVRIGGQEISDAALVTAFERVEAARRGVTLTYFEF 135 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 GTL+A F A ++ +LEVGLGGRLDA N++D D AV+TS+ +DH +LG +RE IG Sbjct: 136 GTLAAFVAFAGAGVENWVLEVGLGGRLDAVNVLDPDYAVITSVDIDHIGFLGDNREVIGF 195 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL- 245 EKAGI R PA+ +P PS++ A + L+ G ++ + A G + Sbjct: 196 EKAGILRPGIPAVCADPNPPSSVLQQAAAQKVALKLTGRDYTLA--------PGAPGQVL 247 Query: 246 -----ENLPLPLVPQPNAATALAALRASGL--EVSENAIRDGIASAILPGRFQIVSESPR 298 E + LP P P + A AA+ + L E+S +++ I + +PGRF+ + P Sbjct: 248 LTIGDEKIELPAGPLPVQSVAAAAVLSRQLVPELSLESLQHAIQNVRVPGRFETIHHDPD 307 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKN--GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 VI DV HNPHAA +L ++ L GR+LAV G L DKD+ G + + SVVD WY A Sbjct: 308 VIIDVGHNPHAAAWLADNLRRLRCGGPGRILAVYGALGDKDVEGVVGAMSSVVDQWYLAG 367 Query: 357 LEGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 L+ PRG ++ L++ + G +F SV++A AAM AK+ D ++V GSF TVA Sbjct: 368 LDVPRGLDSDSLMKRISTVALQGKPGAFGSVSEALAAAMKAAKSGDRIVVFGSFFTVALA 427 Query: 411 ME 412 E Sbjct: 428 RE 429 >UniRef50_Q1QDK0 FolC bifunctional protein n=4 Tax=Moraxellaceae RepID=Q1QDK0_PSYCK Length = 457 Score = 292 bits (747), Expect = 2e-77, Method: Compositional matrix adjust. Identities = 168/446 (37%), Positives = 249/446 (55%), Gaps = 35/446 (7%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP---FVFTVAGTNGKGT 62 TP + L WL+Y++ +H ID+GL RV VA LGV++ A +VFTVAGTNGKG+ Sbjct: 13 TPDNQATLTEWLNYMQQIHVSAIDMGLSRVLPVAEALGVVQSAKDDAYVFTVAGTNGKGS 72 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR--GDIS 120 T + + AAGYK +Y SPHL + ERVR+ G+ + + A+F+++E+AR D++ Sbjct: 73 TTAVIAQMCQAAGYKTALYQSPHLSVFNERVRIDGEMVSDETLIAAFSKVEAARLQCDLT 132 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 L++FE TL+AL +F +A DV +LEVGLGGRLD NI+D D+AV+T+IA+DH DWLG + Sbjct: 133 LSFFEMTTLAALLIFAEADCDVWVLEVGLGGRLDVVNIIDPDMAVITNIAIDHVDWLGDN 192 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-WAFS 239 E+IG EKAGI R I G EMP+++ + A + E++Y + W +S Sbjct: 193 VEAIGAEKAGILRDGISVIYGATEMPNSVQQAIDKHQATCYQVSKEFSYCENNSTRWQYS 252 Query: 240 DAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 +A TL+ LP P + N A AL+A+ AS L+V NAI + + L GRF R Sbjct: 253 NAAVTLQ-LPRPALSLTNTANALSAVLASPLDVDTNAIEQALKTVKLAGRFDYREVHERH 311 Query: 300 -IFDVAHNPHAAEYLTGRMKALPKN------------------GRVLAVIGMLHDKDIAG 340 +FDVAHN E+L ++ L + + + ML DKDI Sbjct: 312 WLFDVAHNDQGVEFLLAQLVPLWQQHLTQQSTSEQVNQTSGEPATIKMLFSMLGDKDINK 371 Query: 341 TLAWLKSV---VDDWYCAPLEGPRGATAEQLLEHLGNG------KSFDSVAQAWDAAMAD 391 + L + + DW+ A ++ PR AT E L L + F + +A A + Sbjct: 372 VVQRLTTAGLPISDWFIAEIDYPRAATTEHLQGILASYVDDSQIHEFARLQEATHAIINA 431 Query: 392 AKAEDTVLVCGSFHTVAHVMEVIDAR 417 ++ +D ++VCGSFHT+ + ++ R Sbjct: 432 SQPQDLIVVCGSFHTIGEALSTLETR 457 >UniRef50_A1UZ44 FolC bifunctional protein n=107 Tax=cellular organisms RepID=A1UZ44_BURMS Length = 461 Score = 291 bits (745), Expect = 3e-77, Method: Compositional matrix adjust. Identities = 181/430 (42%), Positives = 242/430 (56%), Gaps = 27/430 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L +WLS+LE+ H ID+GL R+ V L + P V TV GTNGKG+TC +E+IL+ Sbjct: 31 LDAWLSHLESAHPVGIDMGLARIGQVKDALKLAFACP-VITVGGTNGKGSTCAFIETILV 89 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD----ISLTYFEYGT 128 AGYKVG ++SPHL+R+ ER R+ G+ + + F +E+AR +SLTYFE+ T Sbjct: 90 RAGYKVGCHTSPHLLRFNERARLDGRIVDDEELLPHFEAVEAARTSLPEAVSLTYFEFTT 149 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+ + LF LD VILEVGLGGRLDA N++DAD A+VTSI +DH ++LG RE I EK Sbjct: 150 LAIMHLFASRGLDAVILEVGLGGRLDAVNVIDADCAIVTSIDVDHIEYLGDTREKIAFEK 209 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT----DHDWAFSDAHGT 244 AGIFR KPAI G+P P T+ D A GA L G ++ +S W ++ Sbjct: 210 AGIFRPGKPAICGDPAPPQTLVDHAGAIGADLWLVGRDFRFSTQPGSERQQWTYAGRDKR 269 Query: 245 LENLPLPLVPQPN------AATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 L P + N AA A L VS IR G+A+ LPGRFQ++ P Sbjct: 270 YPALAYPALRGANQLLNASAALAALEALRERLPVSAQDIRLGLANVELPGRFQVLPGKPL 329 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 V+ DVAHNPHAA L + ++ AV G + DKD+AG + LK +D W+ L Sbjct: 330 VLLDVAHNPHAAAVLAQNLDSMGYYPYTHAVFGAMADKDLAGIVERLKGAIDHWHLTDLP 389 Query: 359 GPRGATAEQLLEHLGNGKSFDSVAQ-----------AWDAAMADAKAEDTVLVCGSFHTV 407 PR A A+ +LE + G + AQ A+ A+ A D ++V GSF+TV Sbjct: 390 LPRAAAAD-VLERVLRGAGVEHGAQHNITRHAGPADAFLDALKSASDNDRIVVFGSFYTV 448 Query: 408 AHVMEVIDAR 417 A VM V+D R Sbjct: 449 AGVMPVVDRR 458 >UniRef50_Q0A999 FolC bifunctional protein n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A999_ALHEH Length = 437 Score = 288 bits (737), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 181/438 (41%), Positives = 248/438 (56%), Gaps = 27/438 (6%) Query: 6 TPQAASP--------LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGT 57 TP +A+P L WL + E L I+ GLERV V RLG L P V TVAGT Sbjct: 4 TPGSAAPMPQRDRWRLEDWLRWQEGLSPVEINPGLERVQAVGERLGALTPRCPVITVAGT 63 Query: 58 NGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG 117 NGKG+ LE++L AAGY+ Y+SPHL+RY ER+R+ G + + A TA+F+ +E AR Sbjct: 64 NGKGSCIAYLEAMLGAAGYRTAAYTSPHLLRYNERIRLAGVPVSDEAITAAFSRVEQARQ 123 Query: 118 DISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWL 177 LTYFEYGTL+AL LF +A+ +V +LEVG+GGRLDA N VD D++++TSI LDHT+WL Sbjct: 124 GTPLTYFEYGTLAALSLFSEAEAEVWLLEVGMGGRLDAVNAVDPDLSIITSIGLDHTEWL 183 Query: 178 GPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWA 237 G DRE IG EKAGI R +P +G+ ++P +++D A+ A + G ++++ W Sbjct: 184 GADRERIGAEKAGIMRPGRPVCLGQADLPDSVSDRARTLRAPVTAAGRDFHWRRQALGWD 243 Query: 238 FSDAHGTLENLPLP----LVPQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQ 291 + L+ LP P V NAA +A LR L V A+ G+ SA LPG + Sbjct: 244 WLSGDERLDGLPWPGLTGTVQLDNAAVVIAGLRRLRERLPVDRAALERGLRSARLPGHME 303 Query: 292 IVSESP-RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 V +FDVAHN + L ++ GRV+ + +H K ++G LA + +VVD Sbjct: 304 RVRRRGVEWLFDVAHNEDSVRVLAETVRDEAGKGRVIGLFAAMHRKALSGVLATMGAVVD 363 Query: 351 DWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQ-----AWDAAMAD-AKAEDTVLVCGSF 404 +WY LE P+ E + L SV A AA+AD A+ D V+V GSF Sbjct: 364 EWYLPRLEDPQAHPPEAVAAGLRETGVDASVIHTGGLSALLAAVADRARPGDRVVVFGSF 423 Query: 405 HTVAHVMEVIDARRSGGK 422 TV VM R+GG+ Sbjct: 424 RTVEAVM------RAGGR 435 >UniRef50_Q1QY39 FolC bifunctional protein n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QY39_CHRSD Length = 437 Score = 288 bits (737), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 180/431 (41%), Positives = 243/431 (56%), Gaps = 31/431 (7%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKP--APFVFTVAGTNGKGTTCRT 66 AA+ L +WL+ LE H IDLGLERV+ VA RL +L A V TVAGTNGKG+T Sbjct: 3 AATSLQAWLARLERQHPVAIDLGLERVAEVARRLALLDTPLATRVITVAGTNGKGSTVAM 62 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD---ISLTY 123 LE++ G + Y+SPHL+RY ER+R+ G E ++A F +E+AR D ++LTY Sbjct: 63 LEAVAREHGLRTAAYTSPHLLRYNERLRLAGCEADDAALVEGFEAVEAARLDGDPVTLTY 122 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE GTL+ALWL + Q DV +LEVGLGGRLDA N++D DVAVVT++A DH +LG ++ Sbjct: 123 FEAGTLAALWLIARWQPDVALLEVGLGGRLDAVNVIDPDVAVVTTVAQDHAAFLGTHLDT 182 Query: 184 IGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGA---LLQ-----------RRGVEWNY 229 IGREKAGI R+ +PA++G +P+++ + A A LQ + G EW + Sbjct: 183 IGREKAGILRAGRPAVLGSTTLPASVRERADALSAPVFALQEAFAWRMGDRGQEGSEWQW 242 Query: 230 SVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGR 289 T A L LP P +P NAA AL L + +++ E A R ++ +L GR Sbjct: 243 QGT----APGGEKVALHGLPDPGLPLDNAAVALQTLALADVKLDETATRRALSRVVLAGR 298 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 Q + DV HNPHAA Y+ G++ P+ GR L ++GML DKD G +A L + Sbjct: 299 LQWMGPW---CLDVGHNPHAAAYVAGQLAQRPRRGRRLCLLGMLADKDADGVIAALAPQI 355 Query: 350 DDWYCAPLEGPRGATAEQLLEHL-GNG-KSFDSVAQAWDAAM---ADAKAEDTVLVCGSF 404 D W L G R A QL + G G K A D A+ D +LVCGSF Sbjct: 356 DAWVTVSLSGDRARDAAQLATFVEGRGAKVLHQGASPEDGVRWLHANMDNGDDILVCGSF 415 Query: 405 HTVAHVMEVID 415 TVA + ++ Sbjct: 416 WTVAEALAALE 426 >UniRef50_Q2SJC8 Folylpolyglutamate synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SJC8_HAHCH Length = 430 Score = 288 bits (737), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 171/420 (40%), Positives = 241/420 (57%), Gaps = 27/420 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGV-LKPAPFVFTVAGTNGKGTTCRTLESIL 71 L+ WL Y+ LHS+ I++GL+RV+ V RL + A V T+AGTNGKG+T +E++ Sbjct: 6 LSDWLDYVSQLHSQVIEMGLDRVNDVFRRLCRNARLAKTVVTIAGTNGKGSTLAAVEALA 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 +AAG VG Y+SPH++R+ ERVR+ G ++ + A A+FA +ESARG +LTYFE+ TL Sbjct: 66 LAAGKTVGAYTSPHILRFNERVRINGVDVSDEALEAAFAAVESARGQTALTYFEFTTLVG 125 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 +LF+QA+LD+V+LEVGLGGRLDA NIVD D+AV+TS+ LDH +WLG RE IGREKAGI Sbjct: 126 FYLFQQARLDLVLLEVGLGGRLDAVNIVDPDLAVITSVDLDHQEWLGESREDIGREKAGI 185 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGA---------LLQRRG-----VEWNYSVTDHDWA 237 R P I+ E P+++ DVA + G L+R G ++W D Sbjct: 186 LRPGIPLIIAEEAPPTSVVDVAGKLGCATFIWRQDFTLERTGDASQALQWRGRRKHADI- 244 Query: 238 FSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 ++ L +P N A A+ +SE+ + IA +PGRFQ++ P Sbjct: 245 ------VVDGLSDNGLPMANMAAAMQVAMLLDFPLSESQVAAVIAGVKVPGRFQLLRRDP 298 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 V DV HNPHAA YL + LP +AV L DKD+AG + L V D W PL Sbjct: 299 EVYADVGHNPHAARYLKQWLGGLPVKKPQIAVFSALKDKDVAGIVKELAGVFDRWIVFPL 358 Query: 358 EGPRGATAEQLLEHLGNGKS-----FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 R QL E + +S S+++ A ++A ++ ++ GSF TVA + + Sbjct: 359 NVDRAMPLAQLAELVERNQSAPLQTCASLSECLAQATSEAGSDGRIVAFGSFFTVAEIFQ 418 >UniRef50_A0YB05 FolC bifunctional protein n=1 Tax=marine gamma proteobacterium HTCC2143 RepID=A0YB05_9GAMM Length = 428 Score = 288 bits (736), Expect = 3e-76, Method: Compositional matrix adjust. Identities = 167/419 (39%), Positives = 246/419 (58%), Gaps = 15/419 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WL + E+ HS I+LGLERV VA +G+ V TVAGTNGKG+T L ++L Sbjct: 6 LNEWLVWQESCHSSEIELGLERVGAVARAMGLTLDRSKVITVAGTNGKGSTVAVLNTLLR 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 +AGY V ++SPH +RY ER+++ ++ + SF I+ ARG I LT+FE+GTL+A+ Sbjct: 66 SAGYSVACFTSPHFLRYNERIKLDDCDVSDQLLIESFDRIDQARGTIPLTFFEFGTLAAI 125 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 + + DV++LEVGLGGRLDA NI+DAD+AV+TSI +DH DWLG DRE IGREKAGI Sbjct: 126 DICQHHNADVILLEVGLGGRLDAVNIIDADIAVITSIDIDHEDWLGSDREQIGREKAGIM 185 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNY-SVTDH---DWAFSDAHGT---L 245 RS KP + P+++ A + G + + G ++ Y +H +W+ G L Sbjct: 186 RSGKPTVSAGLTPPASLQIEADKIGTTIYQAGRDFMYRQAREHGRWNWSGQSIDGQPVEL 245 Query: 246 ENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQI-VSESPRVIFDVA 304 L P +P + + AL L+ L +++ + +A+ L GRFQ V E +V+ DVA Sbjct: 246 LALQFPSLPAESVSAALQTLQLLDLPITK-IDYNSLANVDLTGRFQCRVIEGKQVVLDVA 304 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGA 363 HNP AA YL R++ GR +A++ ++ DKDI G + L + D WY L + PR Sbjct: 305 HNPAAASYLAKRLQQTHGVGRTIALVAVMADKDIDGIVEPLINSFDTWYALELADVPRAM 364 Query: 364 TAEQLLEHLGNGKSFD-----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 A L + + + D ++A A+ A++ + ED ++V GSF TVA ++E D + Sbjct: 365 KASALAKKISSLTDVDVHVSSTIAIAFSDALSMMEKEDRLVVFGSFFTVAGLLEFADGK 423 >UniRef50_B8KYD9 Folylpolyglutamate synthase n=1 Tax=gamma proteobacterium NOR51-B RepID=B8KYD9_9GAMM Length = 409 Score = 284 bits (727), Expect = 3e-75, Method: Compositional matrix adjust. Identities = 172/413 (41%), Positives = 231/413 (55%), Gaps = 20/413 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 LA WL YLE LH + IDLGLERV VA L + P TVAGTNGKG+ + L Sbjct: 7 LADWLRYLEGLHPRAIDLGLERVGAVADALELRPPRCSTLTVAGTNGKGSVVAVTAAGLR 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AAG+ VGVY+SPHL+ + ER+ + + +P+ A A+F EIE +RGDISL+YFE+ TL+AL Sbjct: 67 AAGHSVGVYTSPHLIDFNERIVIDDKPVPDEALLAAFEEIERSRGDISLSYFEFATLAAL 126 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 WLF++A +D +LEVGLGGRLDA NI+D D+AV+TSI LDHT+WLGP RE+I EKAGI Sbjct: 127 WLFRRASVDWQVLEVGLGGRLDAVNILDPDIAVITSIGLDHTEWLGPTREAIAPEKAGIA 186 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD------HDWAFSDAHGTLE 246 R KP +V E + P ++A+ + GA ++ RG +W S A D G L Sbjct: 187 RRGKPVVVLETDPPDSLAESLESMGADIKWRGRDWTMSAEQVHLCDGGQVALPDIDGLLS 246 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDVAH 305 + N AL AL +G+ V + + D +AS +PGR Q + V+ DVAH Sbjct: 247 D---------NIGGALQALSLAGV-VIDAPMLDELASVRVPGRRQRRHWKGHEVLLDVAH 296 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGAT 364 N + E + +++LP R LA+ + DK I L D W+ L E PR Sbjct: 297 NLESVEAMVASLESLPGGERTLALFAAMADKPIHAMLNACAGCFDRWFLPDLAEQPRAMK 356 Query: 365 AEQLLEHLGN--GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + + FD AW A A D ++V GSF TV + +D Sbjct: 357 PADIAALMPEVISTCFDDFDDAWSAVTAALVPGDRLIVFGSFITVGAALARLD 409 >UniRef50_C7RCA3 FolC bifunctional protein n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RCA3_KANKD Length = 436 Score = 282 bits (722), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 168/423 (39%), Positives = 241/423 (56%), Gaps = 24/423 (5%) Query: 10 ASP----LASWLSYLENLHS-KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 ASP L W+++LE H I+LGL R+ VA LG+L+ V TVAGTNGKGT Sbjct: 3 ASPDFNTLNEWIAWLEQAHPIHEIELGLSRIQKVANSLGLLELNAPVITVAGTNGKGTVV 62 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 TLES+ + V Y+SPHL+ + ERV+ G + + +F I + DI LTYF Sbjct: 63 ATLESLAVEHDLSVASYTSPHLLAFNERVKHNGYPVSDDLLITAFRHIAQHQSDIPLTYF 122 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E+ TL A W+FKQ +LD+++LEVGLGGR+DA NI++ D+AV+TSI LDH DWLG E + Sbjct: 123 EFTTLVAFWIFKQQELDLIVLEVGLGGRMDAVNIINPDIAVITSIGLDHVDWLGDTLEKV 182 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTI---ADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 EKAGI RS+KP I+ + + S + Q KG + Q +++ Y +WAFS Sbjct: 183 AHEKAGIMRSDKPVIIADSQTQSLLLPEISARQAKGVVAQ---LDYQYEDRGSEWAFSSV 239 Query: 242 HG----TLENLPLPLVPQPNAATALAA-LRASGLEVSENAIRDGIASAILPGRFQIVSES 296 + ++ L + N A+AL A L +V+ +I+ GRFQ +S++ Sbjct: 240 NEGQELSINGLANNDLLVSNLASALQAFLLVFPAKVNPESIKRAYEHLQFIGRFQYLSKA 299 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNG--RVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 P VI DVAHNP +A+ L +++ L + G + A+ GML DKDIAG+LA+ + +D W C Sbjct: 300 PIVIVDVAHNPDSAKILNQKLEQLKERGVEHITAICGMLKDKDIAGSLAYC-TAIDQWNC 358 Query: 355 APLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 L G RG+ E+LL L + K++ + A D ++V GSF TVA Sbjct: 359 IDLPGQRGSKGEELLNKLPEKSQKDAKTYHLLVDALDEYWQHQHQNQALVVFGSFVTVAM 418 Query: 410 VME 412 ++E Sbjct: 419 MLE 421 >UniRef50_B7RU63 FolC bifunctional protein n=1 Tax=marine gamma proteobacterium HTCC2148 RepID=B7RU63_9GAMM Length = 431 Score = 282 bits (722), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 173/420 (41%), Positives = 242/420 (57%), Gaps = 15/420 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 LA WL +LE LH ++LGL+RVS VA LG+L + V TVAGTNGKG+T LES+L Sbjct: 6 LAQWLQHLETLHPNEMELGLDRVSQVADTLGLLPLSSPVVTVAGTNGKGSTVAVLESLLR 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 G++ G ++SPH +R+ ER+RV G E + A+F IE R ISLTYFE+ TL+AL Sbjct: 66 ECGFRPGAFTSPHFLRFNERIRVGGNEAQDEQLIAAFEAIEGVRDGISLTYFEFSTLAAL 125 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +F++ ++D V+LEVGLGGRLD+ N+VDAD+AV+TSI LDH DWLG R I REKAGI Sbjct: 126 MVFEREEVDYVLLEVGLGGRLDSANMVDADIAVITSIDLDHQDWLGDTRGVIAREKAGIM 185 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGA-LLQRRGVEWNYSVTDHDW-----AFSDAHGTLE 246 R KP ++ +PE P + +VA+++ A L R G E+++S W A L+ Sbjct: 186 RVGKPVVIADPEPPGELLEVARDRAAGPLYRLGQEFDFSGPADRWQGRVQALKGDKKLLQ 245 Query: 247 NL-PLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP-RVIFDVA 304 +L + L+P N A A G+E E+ ++ I +I PGR Q + + DVA Sbjct: 246 HLSSVSLLP-ANVCAAAQAAVLLGVEFGEDQLQRAIDGSIRPGRLQRMELGGFHYLLDVA 304 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGA 363 HNP A + L + A P NG+V+A+ + DK I L D W+ + PR Sbjct: 305 HNPAAIDKLLENIAASPCNGKVIALFSAMKDKAIDEMLEACSGHFDAWFLGEQPDNPRAM 364 Query: 364 TAEQLLEHL-GNGKSFDSVA----QAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 Q+ E L G+ S++ QA+ A ED ++V GSF TVA V+ ++ R Sbjct: 365 PTAQIAELLREQGQEAISISKNLRQAFRRAQTVMNGEDLLVVFGSFFTVAAVLPQLEKDR 424 >UniRef50_Q21IZ3 FolC bifunctional protein n=1 Tax=Saccharophagus degradans 2-40 RepID=Q21IZ3_SACD2 Length = 427 Score = 278 bits (710), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 165/422 (39%), Positives = 235/422 (55%), Gaps = 26/422 (6%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLK-----------PAPFVFTVAGTNGKGTTCRTLE 68 +E LHS IDLGL R+ VA L + +P V TVAGTNGKG+ R+ E Sbjct: 1 METLHSSEIDLGLSRILSVAKSLDIFHASSAKVKNANGSSPTVITVAGTNGKGSFVRSCE 60 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 ++L A+G G ++SPH++ Y ER+RV G +L + FA+I+ ARG+ SLTYFE+G Sbjct: 61 AMLGASGMHFGSFTSPHILEYNERIRVDGVDLSDGLICDVFAQIDEARGNTSLTYFEFGA 120 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+AL F ++ D +LEVGLGGRLDA NIVDAD AV+TS+ LDH WLG E IGREK Sbjct: 121 LAALLAFHKSNCDYWVLEVGLGGRLDAVNIVDADFAVITSVGLDHEAWLGNTVEVIGREK 180 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 AGI R+ + A++ ++P ++ DVAQ G G ++ Y TD + L L Sbjct: 181 AGILRANQTAVLASKDLPDSVFDVAQTLGTKCLVGGKDYTYDKTDGGLKVKLNNNKLVEL 240 Query: 249 PLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV-IFDVAHNP 307 +P P+ A A+ + + V + +R +A+ L GRF++++ V + DVAHN Sbjct: 241 AGVNLPIPSVAAAVQVMSLLDISVQASKVRAAVAAVKLAGRFEVIAAQGNVLVLDVAHNA 300 Query: 308 HAAEYLTGRM-KALPKN--GRVLAVIGMLHDKDIAGTLAWLKSVVDDW-YCAPLEGPRGA 363 A E L + K + +N V V+GM+ DK+IA +LA L +V W C + R A Sbjct: 301 MAMELLAKNIAKYVGENEVSSVTCVLGMMADKNIAASLASLLPIVSSWCVCDIPDNKRAA 360 Query: 364 TAEQLLE-------HLGNGKSFDSVAQAWDAAMADAKAEDT---VLVCGSFHTVAHVMEV 413 TAE L E +L +VA A + + +K D V+VCGSF TV + + Sbjct: 361 TAEYLREVLIGLQPNLTQVAQHQTVAAALNECLVLSKVGDKPNLVVVCGSFFTVCNAKQY 420 Query: 414 ID 415 ++ Sbjct: 421 LN 422 >UniRef50_D2UBJ9 Probable folc bifunctional protein [includes folylpolyglutamate synthase and dihydrofolate synthase] n=1 Tax=Xanthomonas albilineans RepID=D2UBJ9_XANAL Length = 423 Score = 275 bits (704), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 184/413 (44%), Positives = 243/413 (58%), Gaps = 18/413 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+ WL+Y+E H I + LER+ VAA +G+ +PA V TV GTNGKG+T +ESI Sbjct: 8 LSDWLTYIEQQHPLAIAMRLERLRAVAACMGLTRPAKRVITVGGTNGKGSTVAFIESIAR 67 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 A G+ VG Y+SPHL+RY ERVR+ G+E ++ A F +E+ARGD LTYFEY TL AL Sbjct: 68 AGGWAVGSYTSPHLLRYNERVRIGGEEASDAQLIAGFVAVEAARGDTPLTYFEYSTLVAL 127 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 WLF+Q+ LD+ +LEVGLGGRLDA N+VDADVAV+T++ +DHT+WLG DRE+IG EK GI Sbjct: 128 WLFEQSGLDLAVLEVGLGGRLDAVNVVDADVAVITTVDIDHTEWLGSDREAIGTEKVGIA 187 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-WAFSDAHGTLENLPLP 251 R KP ++GE + PS++ A GA + R G ++ + D + W + D GT +LPLP Sbjct: 188 RPWKPLVLGEIDPPSSVLRHAYAIGASVLRAGSDFFHEPLDAERWRWRDV-GTELSLPLP 246 Query: 252 -------LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQ-IVSESPRVIFDV 303 L A AL ALR S + +A +GIA+A L GR Q + + V+ DV Sbjct: 247 QLRASVQLANAATAIAALRALRKS---LPRSAYAEGIAAARLGGRLQSCMRDGVEVLVDV 303 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 HNP AA L ++A P G V L DKD G + L+ VD W+ A L G RG Sbjct: 304 GHNPQAARVLAASLQAQPVVGATRVVFAALGDKDAVGVVKALEGQVDAWHLAGLSGVRGQ 363 Query: 364 TAEQLLEHLGNGKSFDSVAQAWDAAMADAKAE-----DTVLVCGSFHTVAHVM 411 + QL E L + +V + D VLV GSFHT A + Sbjct: 364 SGVQLRERLAGTAAAVAVVAESVVQALQQALQQAHPGDRVLVFGSFHTAADAL 416 >UniRef50_A4BRV9 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Nitrococcus mobilis Nb-231 RepID=A4BRV9_9GAMM Length = 426 Score = 275 bits (702), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 177/415 (42%), Positives = 238/415 (57%), Gaps = 12/415 (2%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 S L WL + E LH +TI+LGLERV+ VA RLGV + V TV GTNGKG+T LE+ Sbjct: 3 CSSLRDWLRWQEGLHPRTIELGLERVAAVAKRLGVDRSGARVITVGGTNGKGSTVAYLEA 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 +L A GY GVYSSPH+ RY ER+R+ G+E + A A+F ++ AR D LTYFE+GTL Sbjct: 63 MLRALGYHPGVYSSPHVQRYNERIRIDGREATDEAIVAAFEAVDEARSDTPLTYFEFGTL 122 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +AL LF+ Q DV +LEVG+GGRLDA NI+ ADVAV+T++ LDHTDWLG DR+SIGREKA Sbjct: 123 AALHLFQLTQCDVWLLEVGMGGRLDAVNILAADVAVLTNVELDHTDWLGHDRDSIGREKA 182 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYS--VTDHDWAFSDAHGTLEN 247 GI R +P I G MP T+ A+ G+ +R G +++Y V W + L Sbjct: 183 GIMRPGRPVIFGSVAMPCTVTAHARCLGSDARRLGRDFDYGSPVGVPHWWWRGRSVHLSE 242 Query: 248 LPLPLVPQPNAATALAALRASGLEVSE------NAIRDGIASAILPGRFQIVSESPRVIF 301 LPLP + + AA A+ E +A R + LPGR Q ++ P + Sbjct: 243 LPLPGLSGCHQLANAAAALAALEAFGEPAARLADAARRALPRVYLPGRAQWLAGPPDWLL 302 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGP 360 DVAHN AA L ++A +GRV + G+L KD+AG +A L +VD WY L +G Sbjct: 303 DVAHNAAAAARLPALLRARSGSGRVRCIFGLLRRKDLAGVVAPLLPLVDQWYLLQLADGE 362 Query: 361 RGATAEQLLEHLGNGKSFDSVAQAWD---AAMADAKAEDTVLVCGSFHTVAHVME 412 A A N ++ A + +A+ D ++ GSF VA ++ Sbjct: 363 ALAAAHVAAHLRANEARIAAIGPAHELVSRVCGEAETVDCIVAFGSFRVVAEILH 417 >UniRef50_A4A847 Folylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=unclassified Gammaproteobacteria RepID=A4A847_9GAMM Length = 428 Score = 274 bits (700), Expect = 5e-72, Method: Compositional matrix adjust. Identities = 166/418 (39%), Positives = 243/418 (58%), Gaps = 21/418 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WL YLE LH IDLGL RV A +L + P V TVAGTNGKG+ E IL Sbjct: 6 LGEWLRYLEQLHPVDIDLGLARVRKAAEQLALFPYGPEVITVAGTNGKGSVVFGTECILR 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 A G + G Y+SPHL+ + ER+ V G + + A+F IE+ARGD++LTYFE+ TL+A Sbjct: 66 AHGRRTGRYTSPHLLSFNERIAVDGCPVSDGQIVAAFDAIEAARGDVTLTYFEFATLAAY 125 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 W+F++ ++DV ++EVGLGGRLDA N+VD+D+AV+T+I LDH WLG E I EKA I Sbjct: 126 WIFRELRVDVAVMEVGLGGRLDAVNLVDSDIAVITAIDLDHQHWLGDTVEQIAPEKAAIA 185 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT-DHDWAFSDAHGTLENLPLP 251 R +P ++ E + P T+ + GA+ R G EW++ D + D H +PLP Sbjct: 186 RPGRPVVLAEADYPDTLFHTLDDIGAVPLRAGREWSWRYEGDLQLSLKD-HRESITVPLP 244 Query: 252 LVPQPNAATALAALRASGLEVSE----NAIRDGIASAILPGRFQIVSESPR-VIFDVAHN 306 +P+ AAL+AS + + + R+ + + +P R Q +S + R ++ DVAHN Sbjct: 245 DGLRPSNLG--AALQASAVSLGQTFDPQKSREALRTLSVPARRQTISFAGRALLLDVAHN 302 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-PRGATA 365 P A L +KA P G+ A +G++ DKD+AG A L + VD + G R A Sbjct: 303 PAAMVALVEHLKARPVPGKTFAALGLMKDKDLAGMAASLATAVDGACALAIPGIDRAAAP 362 Query: 366 E---QLLEHLG----NGK-SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 E Q L+ +G G+ + D+V W + + A D +++CGSF++VA +ME+++ Sbjct: 363 EAVWQALDDVGIAIPQGEFTADAV---WSQLLDGSAAGDRLVICGSFYSVAGIMELLN 417 >UniRef50_A1WY03 FolC bifunctional protein n=1 Tax=Halorhodospira halophila SL1 RepID=A1WY03_HALHL Length = 434 Score = 270 bits (689), Expect = 9e-71, Method: Compositional matrix adjust. Identities = 177/427 (41%), Positives = 235/427 (55%), Gaps = 23/427 (5%) Query: 5 RTPQAASP--LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 R PQ A+P L WL+ LE H IDLGLERV+ V RLGVL PA V TV GTNGKG+ Sbjct: 5 RRPQPAAPPDLEGWLARLEAAHPTAIDLGLERVAAVGLRLGVLAPAARVVTVGGTNGKGS 64 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD--IS 120 RTLE++L G +Y+SPH R+ ER+R+ G E+ ++ + +E ARGD +S Sbjct: 65 VARTLEALLRGLGVSTALYTSPHFQRFNERMRLDGVEVADAPLVKALGRVEEARGDADVS 124 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 LTYFE+ TL+A LF ++ V ILEVGLGGRLDA N +DADVAVVT IA DH ++LG D Sbjct: 125 LTYFEHTTLAAFDLFARSGARVWILEVGLGGRLDAVNAIDADVAVVTRIARDHAEFLGDD 184 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV-TDHDWAFS 239 ++I EKAGIFR +PA++G+ + P+ + A E GA + + GVEW +S D W + Sbjct: 185 LQAIAAEKAGIFRKGRPAVIGQQDAPAALRQSALEVGAEVAQAGVEWTFSAEADGRWWWR 244 Query: 240 DAHGTLENLPLPLVP----QPNAATALAAL-----RASGLEVSENAIRDGIASAILPGRF 290 LP +P + N ATALAAL + + DG+ +PGR Sbjct: 245 CGEYHWGGLPASGIPGCAARGNVATALAALVQLPEAVGVDAAAVARLLDGVR---VPGRL 301 Query: 291 Q-IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 + I + S + DVAHN AE L + G+ A+ + KD +A L + Sbjct: 302 ERIEAGSLEWLLDVAHNADGAEELARVLDDRTVTGQTRALFAVAARKDARALVAALSGRI 361 Query: 350 DDWYCAPLEGPRGATAEQLLEHLGN-GKSF----DSVAQAWDAAMADAKAEDTVLVCGSF 404 D WY L+ P A++L L + G+S D VA A A D V+V GSF Sbjct: 362 DAWYLPQLDEPDMRNADELASQLADAGESVVHCGDGVATTLAALQGQAGPGDRVVVFGSF 421 Query: 405 HTVAHVM 411 TVA V Sbjct: 422 RTVAAVQ 428 >UniRef50_UPI0000E88026 folylpolyglutamate synthetase n=1 Tax=Methylophilales bacterium HTCC2181 RepID=UPI0000E88026 Length = 423 Score = 267 bits (682), Expect = 7e-70, Method: Compositional matrix adjust. Identities = 150/409 (36%), Positives = 226/409 (55%), Gaps = 15/409 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L +WL Y+E LH I+L LERV V L + P + V GTNGKG+ C +ESIL Sbjct: 11 LEAWLDYIEKLHPSEIELTLERVREVK-DLANISPDFPIILVGGTNGKGSVCAFIESILH 69 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 A+ K+G Y+SPHL+R+ ER+R+ E+ + A + IE +R DI LTYFE TL+A+ Sbjct: 70 ASDLKIGCYTSPHLLRFNERIRINKHEVDDKAIVNALDHIERSRRDIPLTYFEITTLAAV 129 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +D+ ILEVGLGGRLDA NI ++++T+++LDH +LG + IG EK+GIF Sbjct: 130 KCMNDEAVDIAILEVGLGGRLDAVNIFSPTISLITTVSLDHQAYLGDSVDKIGFEKSGIF 189 Query: 193 RSEKPAIVGEPE-MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLP 251 R PAI+ +PS I+ A + A L G ++N + D +++ + +LPLP Sbjct: 190 RRNIPAIINHKNPIPSMIS-AANKINANLSLLGNDYNLVIHDKSLSYTSNDLSYSDLPLP 248 Query: 252 LVPQPNAATALA-ALRA-----SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 + + LA ALR S + +S AI+ GI+ A + GRF+++ +P V+ DVAH Sbjct: 249 QIKGNHQIINLAGALRCIELLNSTIPISIKAIKKGISDASIRGRFEVLLNNPLVVVDVAH 308 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATA 365 NP +A L +G A+ + DKD+ + +V+D WY A L R + Sbjct: 309 NPESANNLANNFMDAKLDGITTAIFSVFEDKDVLSIIQPFINVIDKWYIAELSSERALSC 368 Query: 366 EQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 E + E L + + F +V A+ A+ +A D +L+ GSF ++ Sbjct: 369 EGIEEALKSVMPTVTVEKFPTVRHAYKEALKNAHDNDNILMFGSFLVIS 417 >UniRef50_B9ZQU2 FolC bifunctional protein n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZQU2_9GAMM Length = 443 Score = 259 bits (661), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 163/417 (39%), Positives = 224/417 (53%), Gaps = 22/417 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESIL 71 LA WL++ E LH +DL LER++LVA RLG+ P P VAGTNGKGT ++L Sbjct: 6 LAEWLAFQERLHPVGMDLTLERIALVADRLGLRGPGTPRTVMVAGTNGKGTVTTRTAALL 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 A G KVG+++SPHL++Y ER+R+ G + +F I+ ARGD SLTYFE+ L+A Sbjct: 66 QAQGLKVGLFTSPHLLQYNERIRLNGMTASDEDLCRAFEAIDQARGDDSLTYFEFAALAA 125 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 WLF++A++DV +LEVGLGGRLDA NI DADVA VT++ LDH WLG RE IGREKAGI Sbjct: 126 AWLFREARVDVQVLEVGLGGRLDAVNIWDADVAAVTAVDLDHQAWLGDSREVIGREKAGI 185 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGA-----------LLQRRGVEWNYSVTDHDWAFSD 240 R+ +P ++GE P ++ D A+ G L+++ + W ++ +W Sbjct: 186 MRAGRPVVLGELSPPQSVLDHARALGCRTVRLGRDFDLLVEQERLVWRWNGVQVEWNVPL 245 Query: 241 AHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 A G +L ++GL S + G+ PGR Q +S P + Sbjct: 246 ARGLSGAALANTATALAVVESLGM--SAGL--SAVTMEQGL-KVRPPGRLQRLSGPPEWL 300 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHN A L ++ P G +A++ ++ DKD + L +VD W PL+ P Sbjct: 301 LDVAHNAQAVAELARWLRENPLVGPTVALVAVMADKDRSAMWRDLDGLVDIWIPVPLDLP 360 Query: 361 RGATAEQLLEHLGNGKSFD-----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 R A L L D + QA A A + +V GSFHTVA V E Sbjct: 361 RALPAPDLAAELEQAGQADVRPAAGIRQALQQATDSAGIQGRCVVFGSFHTVAAVFE 417 >UniRef50_B1FP43 FolC bifunctional protein n=1 Tax=Burkholderia ambifaria IOP40-10 RepID=B1FP43_9BURK Length = 441 Score = 258 bits (659), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 171/437 (39%), Positives = 228/437 (52%), Gaps = 35/437 (8%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 LA WL Y L I+LGL+R+ V +G P V TV GTNGKG+T L++ L Sbjct: 6 LAEWLQYQTTLTVHAIELGLDRIGSVWCNMGAPAPGRIVVTVTGTNGKGSTVAMLDACLR 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 A G + G Y+SP+L RY E++R+ G + + A+F I++ R I LT FE+ TL+A Sbjct: 66 AMGLRTGCYTSPYLHRYNEQIRIIGNCVDDEQLVAAFERIDACRAAIPLTGFEFATLAAF 125 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 L +A LDV +LEVG+GGR DA NIVDADVAV+T++ LDH WLG DR SIGREK GI Sbjct: 126 DLMARADLDVTLLEVGMGGRTDAVNIVDADVAVITTVDLDHLAWLGQDRNSIGREKGGIA 185 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV-TDHDWAFSDAHGTLENLPLP 251 R +PA+VGE E P + D E+GA+ RR +++ + T W + A GT LPL Sbjct: 186 RRGRPAVVGEHEPPQGLLDELSERGAVPVRRDIQYRFDKPTAQGWRWHHADGTTLTLPLL 245 Query: 252 LVPQP----NAATALAALRA--------------------SGLEVSENAIRDGIASAILP 287 + P NAA +A L A ++ SE AI G+ S +P Sbjct: 246 PLEAPVQYDNAACVIATLHALRDALLRCRHERGEAVEAGTFAVQFSE-AIAAGLQSVRIP 304 Query: 288 GRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS 347 GR Q + P V+ DV HNP AA L ++ RV AV G L DKD+ G + L Sbjct: 305 GRLQRIKGEPDVVVDVGHNPQAALALADWLRTSAYR-RVRAVYGALTDKDVEGVVRALGP 363 Query: 348 VVDDWYCAPL--EGPRGATAEQLLEHLGNG------KSFDSVAQAWDAAMADAKAEDTVL 399 +V +W+ L E PRG +L + + VA A A A A D +L Sbjct: 364 LVAEWHLIDLSQETPRGMPMGELFTRVRAAVPRALVEVQPDVASAIVALRKSADAGDCIL 423 Query: 400 VCGSFHTVAHVMEVIDA 416 GSF + +DA Sbjct: 424 TFGSFFVAKAALSTVDA 440 >UniRef50_A4BHC7 FolC bifunctional folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Reinekea blandensis MED297 RepID=A4BHC7_9GAMM Length = 401 Score = 257 bits (657), Expect = 5e-67, Method: Compositional matrix adjust. Identities = 162/412 (39%), Positives = 232/412 (56%), Gaps = 21/412 (5%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 ++ L WL Y+E +H I+LGLER+ VA L + K P V TVAGTNGKGTT + + Sbjct: 4 STDLNEWLRYIEAIHPTEIELGLERLKRVATEL-LQKTPPTVMTVAGTNGKGTTSAAIAA 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 + +AG KVG+Y+SPHL R+ ER+R+ + + + +F +E ARGD+SL+YFEY TL Sbjct: 63 LCQSAGAKVGLYTSPHLFRFNERIRINNEPVADQLLVEAFQAVEQARGDVSLSYFEYTTL 122 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +A W+F+ QLD +LE+GLGGRLDA N++D D+AVVT++ LDH +LG E IGREKA Sbjct: 123 AAFWVFEHEQLDAWVLEIGLGGRLDAVNLIDPDIAVVTNVGLDHQGFLGDTLEEIGREKA 182 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 GI R+ +P ++G E+P ++ + AQ GA L G E + W + + LP Sbjct: 183 GICRTGRPLVLGS-EVPESVLNTAQSVGAELYPFGQEHGLNNDRLYWKTGETRQSALGLP 241 Query: 250 LPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQ-IVSESPRVIFDVAHNPH 308 A AL+ L V E A + + +PGR Q + RVI DV HNPH Sbjct: 242 RANAAAALQAFALSPW---SLPVEECA--SVLQALSVPGRLQSFQHQGRRVIVDVGHNPH 296 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 AA Y+ ++ LP+ R +GML DKD G + L+ + L PRG TA+ Sbjct: 297 AAAYIASQL--LPE--RFHVALGMLADKDSDGFIRALQPAMLSLSTVSLNVPRGLTAQA- 351 Query: 369 LEHLGNGKSFDSVAQA--WDAAMADAKAE---DTVLVCGSFHTVAHVMEVID 415 LG+ + + QA + MA E + + + GSF+TV M+ ++ Sbjct: 352 ---LGDRTTQPVLCQADTIEELMAVLDREHPGEPLFIGGSFYTVCAAMDFLE 400 >UniRef50_Q1YT82 Folylpolyglutamate synthetase n=2 Tax=Proteobacteria RepID=Q1YT82_9GAMM Length = 443 Score = 257 bits (656), Expect = 7e-67, Method: Compositional matrix adjust. Identities = 169/433 (39%), Positives = 243/433 (56%), Gaps = 36/433 (8%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARL-------GVLKPAPFVFTVAGTNGKGTTCR 65 LA WL+ LE H IDLGL+RV+ V + + G P TVAGTNGKG+ Sbjct: 6 LAEWLTLLEARHPSEIDLGLDRVAAVWSAIVQQRRQRGDAISLPTAITVAGTNGKGSCLA 65 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 +++++ A GY+VG+++SPH + Y ER+ +QG + +F EIE+ARG+ISLTYFE Sbjct: 66 SMQAVAHAHGYRVGLFTSPHFLHYNERIAIQGLPAQDRVIVDAFDEIEAARGEISLTYFE 125 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 +GTL+AL +F A LD+V+LEVGLGGRLDA NI+DADVAVVTSIALDH WLG RE I Sbjct: 126 FGTLAALVVFLDAGLDLVLLEVGLGGRLDAINIIDADVAVVTSIALDHQAWLGDTRELIA 185 Query: 186 REKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEW---------------NYS 230 EK GI R +P ++ E + P GA G ++ +S Sbjct: 186 VEKLGIARPSRPLVIAEADGPKGFDRAIAATGAQPFVIGRDFILDPDPDPDPDQKPERFS 245 Query: 231 VTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRF 290 ++ D H + LP+ + N A AL AL +GL +S + + + L GR Sbjct: 246 LSLGDSGAGSQH--FDGLPVSGLMPSNKAAALQALSCAGLSLSADKVVAALDGLALTGRQ 303 Query: 291 Q-IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 Q ++ VI DVAHNP AA+ L + + +GR LAV+ +L+DKD G + L + Sbjct: 304 QRMMVNDCSVILDVAHNPAAAKALAAALPPI--SGRYLAVVSVLNDKDWPGIVEPLSDIF 361 Query: 350 DDWYCAPL-EGPRGATAEQLLEHLGNG----KSFDSVAQAWDAAMADAKAE----DTVLV 400 +WY + + R A+ + E L N + F+SV +A+ +A+A+ E D ++V Sbjct: 362 AEWYVGEISDSERATKAQTMFEVLYNAGLSSRLFESVEEAFTSALAEVAKEAGKDDVIVV 421 Query: 401 CGSFHTVAHVMEV 413 GSF+TV+ V+ + Sbjct: 422 FGSFYTVSAVLNM 434 >UniRef50_D0KZW9 FolC bifunctional protein n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0KZW9_HALNC Length = 429 Score = 253 bits (646), Expect = 9e-66, Method: Compositional matrix adjust. Identities = 160/423 (37%), Positives = 235/423 (55%), Gaps = 13/423 (3%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARL---GVLKPAPFVFTVAGTNG 59 + P + LA WL +LE + IDLGL+RV+ V +L G L P V TVAGTNG Sbjct: 1 MSHAPAEQAALAEWLLWLEARNPARIDLGLDRVADVWRKLKQEGNL-VVPKVITVAGTNG 59 Query: 60 KGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI 119 KG++ LE+IL+A GY+VG Y+SPH+ R+ ER+R+ G ++ + + ++ + G Sbjct: 60 KGSSVALLEAILLAEGYRVGAYTSPHIERFNERIRLMGADIQDHELVVAMCQLAATDGSE 119 Query: 120 SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGP 179 +LTY+E+ TL+A F +A LD+ ILEVGLGGRLDA NI+DAD+A++T+I LDH +LG Sbjct: 120 ALTYYEWATLAAFLAFCRANLDIWILEVGLGGRLDAVNILDADLALITNIGLDHQAYLGD 179 Query: 180 DRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS 239 R IG EKAG+ R + A+ + + ++ D A G L RG ++ W Sbjct: 180 TRTQIGYEKAGVLRKGQAAVYADTDPIESVIDHANAIGCPLIVRGRDFMVEADATGWRLE 239 Query: 240 DAHGTLENLPLP----LVPQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQI- 292 + PLP NAA+ +A L+ S L + ++I G+ SA GRF+I Sbjct: 240 QGDRS-SYWPLPGMFGRTQVDNAASVVALLQHPKSTLNLRASSIEAGVRSAKNRGRFEIW 298 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 V E +VI DVAHN + L + AL R LAV G L DK I ++ + D+W Sbjct: 299 VHEGRQVILDVAHNLESVRVLLDNLHALATPSRRLAVFGALDDKPIEAMISLCRPEFDEW 358 Query: 353 YCAPLEGPRGATAEQLLEHLGNGK-SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 Y L+ R A+ +L L + S S+ A++AA A + D ++ GSF+TV+ + Sbjct: 359 YLGQLDSVRSASIARLSSALDRPQISETSITSAYNAAFAHSAVGDQIIAFGSFYTVSAIR 418 Query: 412 EVI 414 V+ Sbjct: 419 HVL 421 >UniRef50_A5EVX7 Folylpolyglutamate synthase n=2 Tax=Cardiobacteriaceae RepID=A5EVX7_DICNV Length = 422 Score = 247 bits (631), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 152/413 (36%), Positives = 216/413 (52%), Gaps = 19/413 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+ WL++ EN H KT DLGLER+ V +LG K A + TVAGTNGKG+ +E+I + Sbjct: 10 LSEWLAWQENAHPKTWDLGLERIGRVWQQLGAPKIAEHIITVAGTNGKGSCVAWVEAICL 69 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 A G V ++SPH++ Y ER+R + E+ A+F I+ ARG I+LT+FE+ L+A Sbjct: 70 AHGISVASFTSPHVIDYRERIRFNDHMVRETELCAAFEAIDRARGTITLTFFEWSALAAF 129 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +L Q + +LEVGLGGRLDA N++DAD + + I LDHTDWLG + I EKAG+ Sbjct: 130 YLMAQRPPHIAVLEVGLGGRLDAVNLLDADAVIFSRIGLDHTDWLGDHIDKIAAEKAGVL 189 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 R+++ + + + +AD + A L VE WA +LPLP Sbjct: 190 RAKQWVAMAAEQPTNVLADAVKRMQAQLCPYRVESQNDRFHIQWAHYHF-----DLPLPT 244 Query: 253 V----PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPH 308 + Q A A + A ++ ++ + A R + + PR++ DVAHN Sbjct: 245 LLRGEHQLCHCAAAAVILAHWFDLKPELMQRAVKEAHNFARLMVKNTRPRIVIDVAHNAD 304 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 +AE L + L R L V GML DKD L+S+ W+ L G RG A L Sbjct: 305 SAEILAHFLTTLDAPERFLFVCGMLRDKDHDAIFKQLQSLAQHWFLGGLTGARGTDAPTL 364 Query: 369 LEH-LGNG------KSFDSVAQAWDAAMADAKA---EDTVLVCGSFHTVAHVM 411 H L G + V QA+ AA A A +DT++V GSFHTV ++ Sbjct: 365 AMHALAAGIPENAITTCPDVIQAFRAAQQKAHAQDTQDTIVVMGSFHTVQQIL 417 >UniRef50_A1AXP8 FolC bifunctional protein n=5 Tax=Bacteria RepID=A1AXP8_RUTMC Length = 404 Score = 245 bits (625), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 142/410 (34%), Positives = 220/410 (53%), Gaps = 25/410 (6%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + L WL++ +NLH K IDLGLERV+ V +L + V TVAGTNGKG+T + I Sbjct: 5 NTLDDWLNFQKNLHFKKIDLGLERVTKVYQKLFPKGISFKVITVAGTNGKGSTAAFINGI 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 + +KV +SSPH+++Y ER + + + ++F +IE RG +LTYFE+ TL+ Sbjct: 65 YQQSNFKVAKFSSPHILKYNERFVINDAQATDEQICSAFNKIEQIRGKTTLTYFEFSTLA 124 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 AL +F+ ++++ ILEVGLGGRLD+ NIVD DV+++T+I +DH D+LG RE IG EKAG Sbjct: 125 ALIIFELEKVNIAILEVGLGGRLDSVNIVDNDVSIITNIDIDHVDYLGDTRELIGFEKAG 184 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 I R P I + P++I+ A + A L+ + S+ H Sbjct: 185 IMRKNIPCICADINPPASISQYAHQIKAQLEFVKQRYTGSI-----GLIGKH-------- 231 Query: 251 PLVPQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQI-VSESPRVIFDVAHNP 307 Q NAATA+ ++ L +S I GI L RFQI + + VIFDVAHN Sbjct: 232 ---QQQNAATAILTVQKLHKTLPISTIEIETGIKCTQLDARFQIKIINNKTVIFDVAHNA 288 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQ 367 A + L+ + + +A+ L DK+I + + ++D W PL R + Sbjct: 289 AAVKVLSAELA--KQKCSTIAIFSALEDKNIGLMINKISVIIDQWLLVPLNVSRAIGMKA 346 Query: 368 LLEHLG---NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 L N + D++ A + + D + + +++ GSFH +A ++++ Sbjct: 347 LSNQFDLTQNIRVCDNMQDAINQGLNDNQHQ-RIVIFGSFHVIADALKIL 395 >UniRef50_C5BL57 FolC bifunctional protein n=1 Tax=Teredinibacter turnerae T7901 RepID=C5BL57_TERTT Length = 436 Score = 243 bits (619), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 160/432 (37%), Positives = 221/432 (51%), Gaps = 33/432 (7%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVL-------KPAPF---VFTVAGTNGKGT 62 L WL++LE LH I+LGL R+S VA LG AP + TVAGTNGKG+ Sbjct: 7 LNEWLAWLETLHPTEIELGLSRISTVARTLGFAPVMQSRDDSAPVACKLITVAGTNGKGS 66 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 + E++ AG G Y+SPH++ Y ER+R+ G + ++ +F I+ ARGD++LT Sbjct: 67 FVTSCEALFAHAGKTTGAYTSPHILAYNERIRINGAPVSDATIIHAFERIDLARGDLTLT 126 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+ TL+A +F+ A +D +LEVGLGGRLDA N DVAV+TSI LDH +WLG RE Sbjct: 127 YFEFSTLAAALIFRDAGVDYWLLEVGLGGRLDAVNCFFPDVAVITSIDLDHQNWLGDTRE 186 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADV-AQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 +I EKAGI R P + EP P + + QE + V W ++ Sbjct: 187 AIAVEKAGIIRPGIPVVCAEPNPPKNLTQILPQETFYIDVAFHVLQEAGRVRFFWTDAET 246 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQ--IVSESPRV 299 + + L P + A AL L G V A+ I+ L GRFQ +++ V Sbjct: 247 TNSTSQVECAL-PLSSVAAALQVLSLEGYAVPGAALDQTISGLALAGRFQRKFLADGTEV 305 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-E 358 + DVAHNP A + L + A + + A++ M+ DKDIA L + VD WY L + Sbjct: 306 VLDVAHNPAATQLLAKNLAANYEAQKFDALVAMMADKDIAAALQPMLQWVDHWYLLALAD 365 Query: 359 GPRGATAEQL----------------LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCG 402 PR AT EQ LEH + F + + A A +LV G Sbjct: 366 IPRAATPEQFRAQLLELGVAPENIYALEHTSD--FFSTSDDSGVKTSAQASTAKRLLVFG 423 Query: 403 SFHTVAHVMEVI 414 SF+TVA+V+ I Sbjct: 424 SFYTVANVLNEI 435 >UniRef50_Q12D50 FolC bifunctional protein n=4 Tax=Proteobacteria RepID=Q12D50_POLSJ Length = 501 Score = 234 bits (598), Expect = 4e-60, Method: Compositional matrix adjust. Identities = 130/230 (56%), Positives = 164/230 (71%), Gaps = 5/230 (2%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WL++ E LH K+ID+GLERV VA R+G+ P V TVAGTNGKG+TC LE+IL+ Sbjct: 16 LQDWLAHCERLHPKSIDMGLERVQAVARRMGLAFACP-VITVAGTNGKGSTCAMLEAILL 74 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR---GD-ISLTYFEYGT 128 AGY+ GVY+SPHLV + ER RV+G + + A+FA +E+AR GD ISLTYFE+ T Sbjct: 75 EAGYRTGVYTSPHLVHFEERCRVRGDIVNATDLVANFARVEAARVQNGDEISLTYFEFTT 134 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+ L L A+LDVVILEVGLGGRLDA NI+D D AV+TSI LDH ++LG DRESIGREK Sbjct: 135 LAILQLLADAKLDVVILEVGLGGRLDAVNILDTDCAVITSIDLDHMEFLGNDRESIGREK 194 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF 238 AGI R+ KP +V +P P +I D A GA L R G ++N+S W++ Sbjct: 195 AGIMRAGKPVVVSDPVPPQSILDHAAALGADLWRFGQDFNFSGDKQQWSW 244 Score = 89.4 bits (220), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 61/166 (36%), Positives = 86/166 (51%), Gaps = 10/166 (6%) Query: 257 NAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLT 314 NA+ LAAL A L V+ A+R+G++ LPGRFQIV P ++ DVAHNPH+ L Sbjct: 323 NASGVLAALTALRDRLPVTAQAVRNGLSMVELPGRFQIVPGQPTLVLDVAHNPHSVAALA 382 Query: 315 GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN 374 + A+ AV G + DKD+A LA + ++D WY L R A+ E+L Sbjct: 383 ENLDAMGFYPCTHAVFGAMADKDLAPMLARVGPLIDKWYFTDLPTARAASGEELAAKWQA 442 Query: 375 GKSFDSVAQ--------AWDAAMADAKAEDTVLVCGSFHTVAHVME 412 +S V A AA+ A D ++V GSF+TV V++ Sbjct: 443 VESRPDVTATTHKDPELALQAAVRAAGPADRIVVFGSFYTVGGVLK 488 >UniRef50_Q0VPJ2 Folylpolyglutamate synthase / dihydrofolate synthase n=2 Tax=Alcanivorax RepID=Q0VPJ2_ALCBS Length = 410 Score = 226 bits (576), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 161/407 (39%), Positives = 224/407 (55%), Gaps = 16/407 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WL +E +H I+LGL+R+ VA RL V + + V TVAGTNGKG+T R + ++ Sbjct: 10 LPEWLRRIEAMHPADIELGLDRLRDVATRLEVARFSVPVITVAGTNGKGSTLRLMTALAE 69 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 G KV +Y+SPHL + ER+R+ ++ A+FA++E AR + LTYFE+ TL+AL Sbjct: 70 QQGRKVCLYTSPHLHVFNERIRLPDGLASDTQLCAAFAQVELARAGVPLTYFEFTTLAAL 129 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 WLFK + D+++LEVGLGGRLDA NIV+ DV+VVTS+ LDH DWLG RE+I EK GI Sbjct: 130 WLFKDSNADLILLEVGLGGRLDAVNIVEPDVSVVTSVGLDHQDWLGNTREAIAAEKCGIA 189 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP-LP 251 R KP + GE P + + GA+ G +++ W G NLP + Sbjct: 190 RPGKPLVYGEALWPDNLVPLVSTLGAIPVFAGRDFHIDGATL-WLID---GESVNLPEVV 245 Query: 252 LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRF--QIVSESPRVIFDVAHNPHA 309 + N ATA AL +G+ + + +A+ L GR Q+++ FDV HN A Sbjct: 246 RLGADNLATACQALSLAGVNCQQGDLA-AVATLGLFGRCEHQLIA-GVSCWFDVGHNLPA 303 Query: 310 AEYLTGRMKALPKN-GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 + ++ LP G V GM+ DK G +A + + WY A PR A+ L Sbjct: 304 VQRF---LRQLPDCAGTRHLVFGMMADKPFDGVMALFEGMAAHWYLAAPRIPRAASTRVL 360 Query: 369 LEHL---GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 L + SVA A AA+A A A+D V+V GSF+TVA E Sbjct: 361 QSALPATAQYNEYASVAAATHAALAAASADDQVIVFGSFYTVAEARE 407 >UniRef50_B5EK15 FolC bifunctional protein n=2 Tax=Acidithiobacillus ferrooxidans RepID=B5EK15_ACIF5 Length = 429 Score = 224 bits (572), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 160/407 (39%), Positives = 220/407 (54%), Gaps = 29/407 (7%) Query: 26 KTIDLGLERV--SLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSS 83 + I +GLER+ +L A ++ P P V V GTNGKG+T LE+ AGY+VG Y+S Sbjct: 20 EQIVMGLERMRAALAALKMSARLPMP-VMLVGGTNGKGSTVVYLEAFYRQAGYRVGAYTS 78 Query: 84 PHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVV 143 PHL ++TER+R+ G+ PES E+ + I LTYFE TL+A+ + ++DV Sbjct: 79 PHLWQFTERLRLDGRSAPESLWHQQLTEVAATVRQIPLTYFEIATLAAVRMMLATRVDVA 138 Query: 144 ILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEP 203 ILEVGLGGRLDA N D ++VT++ LDH DWLG DR +IG EKAGIFR PA+ G+ Sbjct: 139 ILEVGLGGRLDAVNAFTPDCSIVTTVDLDHQDWLGSDRAAIGHEKAGIFRRGVPALYGDT 198 Query: 204 EMP-STIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVP------QP 256 E P +++ + A LQR G +++ W+ G ++ P PL Sbjct: 199 EDPCASVLEAAVRADVPLQRLGRDFHIDPLHGKWS---GFGHGKDAPPPLWEGAVQWANL 255 Query: 257 NAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS----ESPRVIFDVAHNPHAAEY 312 A A +L L VS+ A+ LPGR Q + + P ++ DVAHNP AA Sbjct: 256 ALALAAVSLLQEKLPVSDAAVSAWTRLPQLPGRCQWLQPWGKDGPDLLVDVAHNPQAARQ 315 Query: 313 LTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQLLEH 371 L + A +GR AV+GML DKDIAGTLA L VD W+ + + PR A+ QL + Sbjct: 316 LAALLAARKGSGRCHAVVGMLADKDIAGTLAPLLHWVDAWHVLEITDTPRAASMLQLRDT 375 Query: 372 LGNGKSFDSVAQAWDAAMADA--------KAEDTVLVCGSFHTVAHV 410 L + + A + DA+M A D +L GSFH V + Sbjct: 376 L---RGLGATAVSADASMEQALERSRTTLATGDILLCFGSFHLVKQL 419 >UniRef50_B6BU94 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=beta proteobacterium KB13 RepID=B6BU94_9PROT Length = 381 Score = 223 bits (568), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 125/389 (32%), Positives = 199/389 (51%), Gaps = 19/389 (4%) Query: 30 LGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRY 89 + L+RV +L L P + TVAGTNGKG+ C + IL + YK+G+Y+SPH + Sbjct: 1 MSLKRVQEFKQKL-TLNPNFKIITVAGTNGKGSVCFYINQILKHSNYKIGLYTSPHFFDF 59 Query: 90 TERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGL 149 ER+ + ++ ES S I SLT+FE TL+A+ +F +D+ ILEVGL Sbjct: 60 NERIVINSEKCSESEILQSLEYILGFDDSDSLTFFEITTLAAILIFDNHNIDIAILEVGL 119 Query: 150 GGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTI 209 GGRLDA N + D++V+TSI LDHT++LG E I EK+G+ R+ KP ++G+ + Sbjct: 120 GGRLDAVNAFEPDISVITSIGLDHTEYLGDTLEKIAVEKSGVMRATKPCVIGDENCIDIL 179 Query: 210 ADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASG 269 + A E ++ +++ ++ D + L V Q N + A+ +L G Sbjct: 180 KNQASEINSIPYFFNKDFDSNIIPFDKS-----------QLTYVQQKNLSCAIFSLHQLG 228 Query: 270 LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAV 329 L + +++ + GRF +S P VI DVAHN + + L + L N + V Sbjct: 229 LTEFTSNLKEELLQQDFFGRFHRISTKPEVIIDVAHNLDSVKNLVHSLLKLG-NKKTYFV 287 Query: 330 IGMLHDKDIAGTLAWLKSVVDD--WYCAPLEGPRGATAEQLLEHLGNGK----SFDSVAQ 383 L DKDI+ + + D W + L PR + +HL S DS+ + Sbjct: 288 FSALKDKDISSIIQLFEKFTYDSEWLISELSSPRAQKLSLIEQHLQKNNYIFDSADSIKR 347 Query: 384 AWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A++ A+ A +D ++V GSF+ ++ + E Sbjct: 348 AYELALNKALNDDRIVVFGSFYVISEIFE 376 >UniRef50_A0Z5L0 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=marine gamma proteobacterium HTCC2080 RepID=A0Z5L0_9GAMM Length = 427 Score = 220 bits (561), Expect = 6e-56, Method: Compositional matrix adjust. Identities = 147/412 (35%), Positives = 213/412 (51%), Gaps = 23/412 (5%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 A L +WL++LE LH + IDL L RV VA +LG+L TVAGTNGKG+ L + Sbjct: 6 AETLDAWLTHLETLHPQKIDLELTRVKTVAHQLGLLPAGCRTVTVAGTNGKGSCVSALSA 65 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 +L G VG Y+SPHL+ + ER+ + G ++ +FA IE R ISL+YFE+ TL Sbjct: 66 LLRQKGLSVGCYTSPHLLTFNERITINGIPASDAEIMGAFALIEERRAAISLSYFEFATL 125 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +AL LF++ + V ILEVGLGGRLDA N+VDAD V+TSI +DHT+WLG R+ I EKA Sbjct: 126 AALLLFQEKGVAVQILEVGLGGRLDAVNMVDADACVITSIGIDHTEWLGDTRDLIAIEKA 185 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 G+ R KPA+V E ++P T+ + GA N + D DW S+ TL + Sbjct: 186 GVARLGKPAVVAESDLPLTLLPTLEALGA---------NVAALDRDWLISEQMLTLPDGT 236 Query: 250 ---LPLVP---QPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV-IFD 302 LP VP N A+ A + ++ I + +PGR Q + R+ D Sbjct: 237 QRLLPTVPGLQTSNLGAAVVAAMKLNVTPDQDCIDKAFLALSVPGRQQQLVAMDRLWWLD 296 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG--- 359 VAHN + L + + A+ G + DK + + + + W+ EG Sbjct: 297 VAHNCESVARLAAAIAEKTGGVQTHAIFGAMADKPLRAMIELISEGISSWHLPAHEGIAR 356 Query: 360 -PRGATAEQLLEHL---GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 A QL++ + + + + A++ +K D ++V GSF TV Sbjct: 357 AANPADLAQLIKRISPKATVQCYPTPESAFNGIENVSKPGDRIVVFGSFVTV 408 >UniRef50_C5CEI6 FolC bifunctional protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CEI6_KOSOT Length = 428 Score = 216 bits (550), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 142/416 (34%), Positives = 218/416 (52%), Gaps = 23/416 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L YL +L I G+ R+ ++ LG + + V VAGTNGKG+T + SIL AGY Sbjct: 7 LDYLYSLRRFGIKPGVRRIKMLLELLGNPQDSLNVVHVAGTNGKGSTVAFISSILKEAGY 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYGTLS 130 +VG Y SPHL+ +TER+ + G ++ E +I ++ S T+FE T Sbjct: 67 RVGTYISPHLIDFTERMTINGLQIKEEVVVEILNKIRPHITEVANSKFGSPTFFEVVTAM 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A FKQ ++D +LEVGLGG DATN+V V+V+T+ DH D LG D SI +E AG Sbjct: 127 AFVYFKQQKVDFAVLEVGLGGENDATNVVKPLVSVITNSDYDHMDILGNDITSIAKEDAG 186 Query: 191 IFRSEKPAIV-GEPEMPSTIADVAQEKGALLQR--RGVEWNYSVTDHDWAFSDAHGTL-- 245 I + + E E I + +EK A + + R +++ + +D W + G Sbjct: 187 IIKENGFVVTAAEGEALDVIKKIGEEKRARIYQIGRDIKYEFVNSDLKWQRFNVKGIFSE 246 Query: 246 -ENLPLPLVPQ---PNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 +NL +PL+ + NA+ A+ A LR +E+S+ +IR G+ + PGRF+IV ++P Sbjct: 247 SDNLKIPLLGKYQLINASCAVGAIEILRFYDIEISDESIRKGLENTFWPGRFEIVQDAPM 306 Query: 299 VIFDVAHNPHAAEYLT-GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 V+ D AHN AA+ L M+ L K +++ VIG++ DK++ + L + Sbjct: 307 VVLDGAHNHLAAKRLKEALMEVLEKKDKLILVIGIMKDKEVEKIVKELAPLAYKVVATSP 366 Query: 358 EGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 + PR T+ L E + N + V A + A+++AK D V V GS +TV Sbjct: 367 KTPRATTSHDLREIVVKFNKNISVVEDVETALELALSEAKENDIVCVTGSLYTVGE 422 >UniRef50_B0VF02 FolC bifunctional protein n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VF02_9BACT Length = 426 Score = 203 bits (517), Expect = 8e-51, Method: Compositional matrix adjust. Identities = 134/416 (32%), Positives = 212/416 (50%), Gaps = 18/416 (4%) Query: 16 WLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 +L ++ +S + L L R+ + +G + F + GTNGKG+ C TLE++ +G Sbjct: 6 FLEHIFKRYSGNVKLELNRMQGLLNDMGNPERKLNGFHIGGTNGKGSVCATLEALCRESG 65 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 + +SPHL+ Y ER R+ G+E +F E+ ++FE T A +F Sbjct: 66 LNTALNTSPHLINYNERFRINGKEPSFETILNTFLRYENLFDKWEASFFEITTALAFSMF 125 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 + +DV I+EVGLGGRLDATN+ DVAV+T+I LDH LG E I EKAGI + Sbjct: 126 SEHNVDVSIIEVGLGGRLDATNLFIPDVAVITNIGLDHIKTLGGTLEIIAGEKAGIIKEG 185 Query: 196 KPAIVGE-PEMPSTIAD-VAQEKGALLQRRGVEWNYSVTDHDWA---FSDAHGTLE--NL 248 P ++G+ E P +I + VA+ K + R +W S+ + + F + G E NL Sbjct: 186 IPLVLGDIEESPRSIIEAVAKTKKVPVFRYKRDWQTSIRNDNLTGINFDYSFGNYEFPNL 245 Query: 249 PLPLVPQPNAATALAALRA-------SGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 L+ + A +AL A L V+E IR + GR Q++S+ P +I Sbjct: 246 EANLMGEHQAINIGSALTAFILYAEKKKLPVAEEVIRKALQHISWKGRMQLLSQKPIIII 305 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D AHN H + L ++ + N +V ++ +L DKD L+ + + Y A + R Sbjct: 306 DGAHNVHGVKALMSTLEKIFPNRKVKFMVSILRDKDYKQMLSLICPKAEQIYVARNQSER 365 Query: 362 GATAEQ----LLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 A+ E + E+ K+ +VA+A+ A+ + K +D ++VCGS TV V+E+ Sbjct: 366 AASVEDQVAVIEEYNIPYKTAPTVAEAYSLAVKECKEDDILIVCGSLFTVGEVLEI 421 >UniRef50_Q28WD6 FolC bifunctional protein n=2 Tax=Rhodobacterales RepID=Q28WD6_JANSC Length = 421 Score = 200 bits (509), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 148/416 (35%), Positives = 210/416 (50%), Gaps = 26/416 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKP-APFVFTVAGTNGKGTTCRTLESILMAAG 75 L+ + LH K IDL L+R+ + LG + P V VAGTNGKG+T + + L AG Sbjct: 9 LARMMALHPKIIDLTLDRMWRILYALGDPQTRIPPVIHVAGTNGKGSTQAMIRAGLEGAG 68 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 Y+SPHL R+ ER+R+ G+ + E + +A G +TYFE T +AL F Sbjct: 69 LTTHAYTSPHLARFHERIRLAGELIDEDHLSRILDTCLAANGPDPITYFEITTAAALHAF 128 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIFRS 194 Q D +LEVGLGGRLDATN++DA ++V+T I LDH +LG E+I EKAGI + Sbjct: 129 AQMPADYTLLEVGLGGRLDATNVIDAPALSVITPIDLDHQQFLGDTLEAIAGEKAGIIKR 188 Query: 195 EKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 P +VG + E I A GA + G W+ + F D G L +LPLP Sbjct: 189 GIPVVVGPQQDEALEVIEARAARLGAPVIAHGQHWHVTTERERLIFQDETGLL-DLPLPS 247 Query: 253 VPQP----NAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP--------RVI 300 + P NA TALAALR G+ ++ A+ D I P R Q + P + Sbjct: 248 LAGPHQIQNAGTALAALRTLGVGDADAAMTD----TIWPARMQKLRHGPLTEVAPSVELW 303 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 D HNPHAA + ++ LPK L + GML+ KD+ G +A L V+ + G Sbjct: 304 LDGGHNPHAARAIAATLETLPKRPTYL-ICGMLNTKDVTGYMAPLVPWVESLTAVSIPGQ 362 Query: 361 RGA-TAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDT---VLVCGSFHTVAHVME 412 +AE+ E + +A DAA+ + +D VL+CGS + +++ Sbjct: 363 TATLSAEETAEAARSVGLTTRIAPGVDAALTEIAVDDPRARVLICGSLYLAGEILK 418 >UniRef50_B9L391 Folylpolyglutamate synthase (Folylpoly-gamma-glutamatesynthetase) n=2 Tax=Thermomicrobia (class) RepID=B9L391_THERP Length = 454 Score = 200 bits (509), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 152/407 (37%), Positives = 218/407 (53%), Gaps = 22/407 (5%) Query: 30 LGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRY 89 +GL R + + + LG +AGT GKG+T L S+L AAGY+VG+Y+SPHL Sbjct: 33 IGLARTAWLCSALGDPHRRYRSVHIAGTKGKGSTAALLSSMLQAAGYRVGLYTSPHLHTL 92 Query: 90 TERVRVQGQEL-PESAHT--ASFAEIESARGDI-----SLTYFEYGTLSALWLFKQAQLD 141 ER+++ GQ + PE+ T A AE+++A + T FE T+ A F + +D Sbjct: 93 RERIQIDGQPIAPETFGTLMAELAEVDAALQRAHPDWGAATAFELVTVLAFAAFARVPVD 152 Query: 142 VVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG 201 + ++EVGLGGRLDATN++ DVA++T I DH LG +I REKAGI + +P + Sbjct: 153 IAVIEVGLGGRLDATNVILPDVALITRIGYDHMAILGSTLAAIAREKAGIVKPGRPVVSA 212 Query: 202 --EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQ---P 256 EPE I VAQE+GA L G +W + T +AF L +L L L Sbjct: 213 PQEPEATRVIEAVAQERGAPLWLGGRDWQVTGTWRRFAFHAPGWELADLALALRGSHQVE 272 Query: 257 NAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYL 313 NA ALA+ L + E+AIR G+A+A+ PGR +++ E+P V+ D AHN +A+ L Sbjct: 273 NAGVALASLPWLARVEMVAPESAIRQGLATAVWPGRLELLRENPSVVVDGAHNRESAQRL 332 Query: 314 TGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG 373 + + R+ V+G++ DK+I +A L + D + PR A+AE+LL Sbjct: 333 AEAVHESFRWRRLWLVLGIMRDKEIERIVAALAPLADALFAVEGFAPRAASAERLLAAWA 392 Query: 374 N---GK---SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 GK S+ SV A AA+ A D VLV GS VA E + Sbjct: 393 ASTVGKPAASYRSVEDALRAALEQADPADLVLVTGSLSMVAAAREAL 439 >UniRef50_C6NYQ6 Dihydrofolate synthase / Folylpolyglutamate synthase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NYQ6_9GAMM Length = 437 Score = 200 bits (509), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 156/405 (38%), Positives = 211/405 (52%), Gaps = 24/405 (5%) Query: 28 IDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 I+LGL R+ A L + P+ V TVAGTNGKG+T LES+ AGY+V Y+SPHL Sbjct: 20 IELGLARMRAAMAELEIAPRQPWPVITVAGTNGKGSTVAYLESLYRQAGYRVAAYTSPHL 79 Query: 87 VRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILE 146 R+ ER+R+ G L E A+ E+ G I LTYFE TL+AL L + A +++ILE Sbjct: 80 WRFVERLRIDGTVLTEGQWLAALEEVAQDAGHIPLTYFELATLAALLLVRAAAPELLILE 139 Query: 147 VGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMP 206 VG+GGRLDA N V D++++T++ +DH WLG RE+IGREKAGI R P + G+ + P Sbjct: 140 VGMGGRLDAVNAVHPDLSIITTVDMDHQQWLGDSREAIGREKAGILRRGVPLLYGDADDP 199 Query: 207 ST-IADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV----PQPNAATA 261 T + A+ GA + G E V D G +LP PL N A A Sbjct: 200 CTSVLTAARASGAPIYLLGRE---LVVDPVAGVLHMGGECWHLPEPLWGGREQWDNLALA 256 Query: 262 LAALRASGLEVSENAIRDGI---ASAILPGRFQIV----SESPRVIFDVAHNPHAAEYLT 314 AA R + A+ G LPGR Q + S+ P ++ DVAHNP A L Sbjct: 257 TAATRLLRERLPAAAVEPGADWRCPPRLPGRCQRLRPWGSDGPTLLLDVAHNPQAVRQLA 316 Query: 315 GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQLLEHLG 373 ++ P RV A+ +L DKD+ LA L +V W+ L E R LL L Sbjct: 317 SVLRRHP-GARVYALFNLLADKDLDACLAPLAGLVQHWFPVALPESARTRPWPDLLAALD 375 Query: 374 N-GKSFDSV-----AQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 G ++ +V + + +AA A A D VL GSF +A + E Sbjct: 376 TRGLTWTAVEGGDCSASLEAACAGLGAGDLVLCFGSFQVLAQLPE 420 >UniRef50_B5YJI6 Folylpolyglutamate synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YJI6_THEYD Length = 438 Score = 199 bits (505), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 130/410 (31%), Positives = 214/410 (52%), Gaps = 33/410 (8%) Query: 28 IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLV 87 I LGL RV V +LG + +AGTNGKG+ + + ++ A G VG+++SPHL Sbjct: 22 IKLGLNRVISVLEKLGNPHHSFKSIHIAGTNGKGSVSKIIYCLIRAQGLSVGLFTSPHLT 81 Query: 88 RYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEV 147 R+TER+ V E+ E +I+ + LT+FEY T+ AL FK+ ++ ++E Sbjct: 82 RFTERIIVNDIEISEEEVEHLIEKIKPFSDE--LTFFEYVTVMALQYFKEKGIEYAVIET 139 Query: 148 GLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEM 205 G+GGRLDATN+V+ ++V+T+I LDH ++LG D SI +EKAGI ++ P + + E+ Sbjct: 140 GMGGRLDATNVVNPLISVITNIGLDHQEFLGADLASIAKEKAGIIKNGIPVVSSSQKKEV 199 Query: 206 PSTIADVAQEK------------GAL--LQRRGVEWNYSVTDHDWAFSDAHGTLE-NLPL 250 I A+E G L + G+ +++ + ++F + +L+ NL L Sbjct: 200 EKVIIKKAEEMESPLFIYDRDFIGVLKSMSLEGIVFDF----YPFSFQPSTSSLQSNLFL 255 Query: 251 PLV---PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNP 307 PL N + AL A +ENAI++G+ + +PGR +I+ + P +FD+AHNP Sbjct: 256 PLTGFHQLENVSVALKAFINIYPMYNENAIKEGLKNVKIPGRLEIIYDKPLAVFDIAHNP 315 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQ 367 AAE L +K L + + + V M+ DK++ + ++ R T ++ Sbjct: 316 DAAEVLIKSLKTLT-DKKPVVVFAMMRDKNVNEFIKCFENYAYKMIFTVPNYERALTYKE 374 Query: 368 LLEHLGNGKSFDSVAQAWDA-----AMADAKAEDTVLVCGSFHTVAHVME 412 LL+ L N K D V + +A ++ ++ VL GS + V + E Sbjct: 375 LLKRL-NDKKIDFVPEPLEAFRNAISLCKNNSDIYVLCTGSAYLVGEIKE 423 >UniRef50_A0LIV6 FolC bifunctional protein n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LIV6_SYNFM Length = 431 Score = 195 bits (496), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 135/420 (32%), Positives = 205/420 (48%), Gaps = 29/420 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + YL L I GL + + RLG + +AGTNGKG+T L S+L G Sbjct: 13 VDYLFGLQKHGIKFGLNSTNNLLMRLGNPHRSLRCIHIAGTNGKGSTAAMLSSMLRKHGV 72 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL-TYFEYGTLSALWLF 135 +VG+Y+SPHLVR+TER R+ +E+ A F ++ D T+FE T AL LF Sbjct: 73 RVGLYTSPHLVRFTERFRIDEREVRIDRILAIFEKVRKQIDDREPPTFFEVVTAMALLLF 132 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 + ++ ++E G+GGRLDATN++ V+V+T++ DH ++LG SI REKAGI + E Sbjct: 133 AEENVEWAVIETGMGGRLDATNVIHPRVSVITNVTFDHQEYLGSTLSSIAREKAGIIKEE 192 Query: 196 KPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWN----------YSVTDHDWAFSDAHG 243 P + G +P + + Q K A+L R G E+ Y DW Sbjct: 193 VPVVTGVTQPLVHGVLTATCQRKRAVLYRLGKEFKARRRPGGAARYQGLKWDWP------ 246 Query: 244 TLENLPLPLVPQ-PNAATALAALRA----SGLEVSENAIRDGIASAILPGRFQIVSESPR 298 +LE + LP V Q NAA A+A L + A+ G+++ P R +++ P Sbjct: 247 SLE-ISLPGVHQVRNAALAIAVLEVLEEKGDFYIDSGAVELGLSAVRWPARLEVLGRRPL 305 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 ++ D AHNP AE L ++ ++ V+G++ DKDIAG L + + Sbjct: 306 IVLDGAHNPQGAESLRDALRNCFTYQKLHLVMGIMEDKDIAGIFRRLLPLAETAIFTQPR 365 Query: 359 GPRGATAEQLLE----HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 R A A++L + + GN VA+A A A +D + + GS + V E+ Sbjct: 366 YSRAAKADRLRQLARPYAGNHCVIPDVAEAIQQAGRFAGPDDLICITGSLYFAGEVKELF 425 >UniRef50_A4XL37 FolC bifunctional protein n=5 Tax=Clostridia RepID=A4XL37_CALS8 Length = 431 Score = 192 bits (489), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 132/414 (31%), Positives = 202/414 (48%), Gaps = 25/414 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L Y+ + + LGLE + + +G + + VAGTNGKG+TC + +L+ AGY Sbjct: 9 LEYIHGTYKFGVKLGLENIKKLLELMGNPQKDLRIVHVAGTNGKGSTCAFINQMLIEAGY 68 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESA-HTASFAEIESARGDISL-------TYFEYGT 128 KVG+Y+SP+L + ER+++ +P S A+ E + D+ + T FE T Sbjct: 69 KVGLYTSPYLEFFNERIKINN--IPISNDELATITEFVKDKVDLMISQGFNHPTEFEIVT 126 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDA-DVAVVTSIALDHTDWLGPDRESIGRE 187 A FK+ +D V+LEVGLGGR DATN+V+ ++ ++TSI DH D LG E I E Sbjct: 127 AIAFEYFKRTNVDFVVLEVGLGGRFDATNVVETPELCIITSIGYDHMDILGQTIEQIAYE 186 Query: 188 KAGIFRSEKPAIVG---EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA--- 241 KAGI + I+G E I+ V ++K A L ++ D D Sbjct: 187 KAGIIKESSTVILGLQRYKEAIDVISKVCKQKNANLIEVKSDYKIIKNTLDGIVFDCTTP 246 Query: 242 HGTLENLPLPLVPQPNAATALAALRA-----SGLEVSENAIRDGIASAILPGRFQIVSES 296 G +NL + L+ AL + A +S A+ G+ +A GRF+I+S+ Sbjct: 247 KGIYKNLEINLLGVHQVENALNCIYAFEYLSDKYNISTIALVKGLLNAKWNGRFEIISKE 306 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD--WYC 354 P VI D AHN L K K+ ++ AV+G+L DK+ L+ +K V D + Sbjct: 307 PLVILDGAHNIDGMRVLVDSCKQYLKDKKISAVVGILKDKEYKKMLSMIKEVTSDVIFTL 366 Query: 355 APLEGPRGATAEQLLEHLGNGKSF-DSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 P + + AE L G F +A D ++ A+ + +L+CGS + V Sbjct: 367 VPYQKRAFSPAEAKEAALKFGFEFIKDYKEAIDVSLKKAEKDTAILICGSLYLV 420 >UniRef50_C0GS76 FolC bifunctional protein n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GS76_9DELT Length = 428 Score = 192 bits (487), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 133/411 (32%), Positives = 202/411 (49%), Gaps = 22/411 (5%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL++L ++LGLER+ R+ P++ + GTNGKG+T LES+ G K Sbjct: 13 YLDHLGLFRMELGLERMQKALQRVDFRPGEPYLVQIIGTNGKGSTASYLESLARMHGLKT 72 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQA 138 G+++SPHLV ER V G++LP+ A + ++ + GD+ LTYFE+ TL+A+ +F+ A Sbjct: 73 GIFTSPHLVSVKERALVNGKKLPDKAWLKAANLLDGSCGDLELTYFEFLTLAAVLMFRDA 132 Query: 139 QLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPA 198 +D+ ++E GLGGR DAT ++A + V T I +DHT LG E I R+KA R++ Sbjct: 133 GVDLGVMEAGLGGRYDATTTLEAGLQVYTCIDMDHTSILGETIEEIARDKAMAVRADSTV 192 Query: 199 IVGE---PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV-- 253 ++ P+ T+ A G+ L R V+ + D F+ +P + Sbjct: 193 VLARQNYPQAAETVQSTASGVGSSLYR--VQDFFVQKDAGTYFTGEPDFFVGTDVPGIHG 250 Query: 254 --PQPNAATALAALRASG----LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNP 307 NA TAL A R L++ + LPGR +VS P +I D AHNP Sbjct: 251 DYQLQNAETALVAWRILSRRFDLKMDPQKCLQALQDTFLPGRMHVVSRDPLIILDGAHNP 310 Query: 308 HAAEYLTGRMKALP-KNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL--EGPRGAT 364 A + + + L + G + V L DK+I L L+ P GPR Sbjct: 311 GAMDRVHSFLGGLAIRPGHI--VFTCLSDKEIEPMLQMLRRFYPARVLVPDMGSGPRSMD 368 Query: 365 AEQLLEHLGNG-KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 ++LL +G+G K D + A +D VLVCGS + + HV + Sbjct: 369 RQELLSMMGDGAKPLDDLEGFLKGL---APGDDPVLVCGSLYLLGHVYRLF 416 >UniRef50_Q3A6L0 Folylpolyglutamate synthetase; dihydrofolate synthetase n=1 Tax=Pelobacter carbinolicus DSM 2380 RepID=Q3A6L0_PELCD Length = 422 Score = 191 bits (485), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 143/422 (33%), Positives = 210/422 (49%), Gaps = 31/422 (7%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L+YL L I LGL + + ARL + A + VAGTNGKG+ IL AGY Sbjct: 7 LAYLYGLQRFGIKLGLTNIQTLLARLDHPERAMRIVHVAGTNGKGSVSAATALILQTAGY 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFK 136 + G+Y+SPHL +TER+R+ G ++ E + E+ + G + +T+FE+ T AL F+ Sbjct: 67 RTGLYTSPHLHSFTERIRIDGVQVSEPDMVSLVDEVRAVVGSLPVTFFEFTTAMALVYFR 126 Query: 137 QAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEK 196 D +LEVG+GGRLDATN V+++++VVT + DH + LG D +I EKAGI + + Sbjct: 127 NRHTDFAVLEVGMGGRLDATNAVESEISVVTPVCCDHAEHLGADLATIAGEKAGIIKRQV 186 Query: 197 PAIVGE--PEMPSTIADVAQEKGALLQRRGVEW--NYSVTDHD--WAFSDAHGTLENLPL 250 P ++ E P+ + A E A + W ++ + DHD + F TL+ L Sbjct: 187 PVVIAEQHPDAQRVLLTKAAEMLAPV----CLWDRDFRIIDHDTHFDFFAPSLTLKGLRP 242 Query: 251 PLV---PQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 L + N A ALAA LR G+ +SE A+R G+ PGR + + R++ D A Sbjct: 243 GLAGAHQRQNLAVALAACMSLRNRGVALSEEALRYGVEKVQWPGRLEWWRQQRRILLDGA 302 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA--------- 355 HN H + R A +V V+G+ + I L L Y Sbjct: 303 HN-HGGAVVLARYLASLDGKKVRWVVGIKGQRCIDDILTPLLPHTAHLYATLPPVDQGIE 361 Query: 356 PLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 P + R A A +L K++ + A A AA+AD +D VLV GS VA V + + Sbjct: 362 PDKLVRAARAAGVL-----AKAYATPADAMTAALADQGEDDVVLVAGSLFLVAAVRDYLM 416 Query: 416 AR 417 R Sbjct: 417 DR 418 >UniRef50_Q1D8V1 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Cystobacterineae RepID=Q1D8V1_MYXXD Length = 410 Score = 190 bits (483), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 141/395 (35%), Positives = 198/395 (50%), Gaps = 22/395 (5%) Query: 32 LERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTE 91 +ERV A LG + VAGTNGKG+TC + L AAG++VG+Y+SPHLVR E Sbjct: 1 MERVQEALAALGHPERRYPALHVAGTNGKGSTCAMTAASLHAAGHRVGLYTSPHLVRVNE 60 Query: 92 RVRVQGQELPESAHTASFAEI-ESARGDIS--LTYFEYGTLSALWLFKQAQLDVVILEVG 148 R+RV +++ ++ E+ E +S +TYFE+GT+ ALW F Q ++DV +LE G Sbjct: 61 RIRVDSEDISDADFGLRILEVLERYPSAVSSPMTYFEFGTVVALWHFAQVRVDVAVLETG 120 Query: 149 LGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PEMP 206 LGGRLDAT V +T ++ DH ++LG +I EKAGI + P +V PE Sbjct: 121 LGGRLDATTAASPVVTAITPVSFDHMEYLGDTLAAIAGEKAGILKPGVPCVVARQAPEAL 180 Query: 207 STIADVAQEKGALLQRRGVEWN-YSVTDHDWAFSDAHGTLENLPLPLV---PQPNAATAL 262 I A++ GA ++ G ++ D ++ A +L+ L + L + NAA AL Sbjct: 181 EAILRKAEQVGAPVRLEGRDFTGERQPDGGLSYRGATWSLDGLSVALRGPHQRQNAAVAL 240 Query: 263 AALRA---SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKA 319 A L A G+ A R G+ASA PGR + V + P ++ D AHNP E L +K Sbjct: 241 ACLEALQERGVTAPPEAARAGLASACWPGRLEEVGQQPILLLDGAHNPAGVEVLLASLKD 300 Query: 320 LPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFD 379 L R+ V G++ DKD + L PLE PR E +L ++ Sbjct: 301 LYPGRRLHLVFGVVGDKDRGPMMRALLPECASVQLTPLETPRSLAPEA---YLAEARALC 357 Query: 380 SVAQAWD-------AAMADAKAEDTVLVCGSFHTV 407 + AW AA A A D VL GS V Sbjct: 358 ADVTAWPDADAALAAARKRAAANDLVLCTGSLFLV 392 >UniRef50_B0K4K8 FolC bifunctional protein n=15 Tax=Clostridia RepID=B0K4K8_THEPX Length = 429 Score = 190 bits (482), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 136/418 (32%), Positives = 213/418 (50%), Gaps = 32/418 (7%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + Y+ ++ I LGLE + + +G + + + VAGTNGKG+T + +IL AGY Sbjct: 7 IGYIHGIYKFGIKLGLENIRKLLDYMGNPQKSLKIIHVAGTNGKGSTSAFISNILQQAGY 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE------SARGDISLTYFEYGTLS 130 KV +Y+SP+L + ER+R+ G+ + + I+ G T FE T Sbjct: 67 KVALYTSPYLEEFEERMRINGENISKEKLIYYVEYIKPIISRMVEEGYNHPTEFEVVTAI 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKA 189 A F ++D V+LEVGLGGR DATN +D+ V+V+T+I DHTD LG I EKA Sbjct: 127 AFKYFYDEKVDFVVLEVGLGGRFDATNAIDSSLVSVITTIDYDHTDRLGHTLGEIAYEKA 186 Query: 190 GIFRSEKPAIVG---EPEMPSTIADVAQEKGA---LLQRRGV---EWNYSVTDHDWAFSD 240 GI + +K +V +PE I + + + A +L++ V E N D+ D Sbjct: 187 GIIK-QKGVVVSFYQQPEAMKVIIEACEVRNAYLTVLEKSNVIIKEQN-----PDFQIFD 240 Query: 241 AHGTLENLPLPLVPQP---NAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVS 294 + ++L + L+ + NAA A+ + L+ G E++E IR+G+ A PGR +++ Sbjct: 241 -YKKYKDLKITLLGEHQIYNAALAIESVEKLKMYGYEITEKDIREGLYRAKWPGRLEVMR 299 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 + P V+ D AHNP L +K L K +++ VIGML DKD L + + Sbjct: 300 KKPYVVIDGAHNPQGMTVLKESLK-LFKYDKLILVIGMLKDKDTQKMLDIIVPEANMIIT 358 Query: 355 APLEGPRGATAEQLLEHLGNGK--SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 R A +L E + K + +++ +A A+ AK ED VL CGS + + +V Sbjct: 359 TTPISERAYKASELAERIEKEKVIAIENIEEAVKYALDIAKEEDMVLFCGSLYMIGYV 416 >UniRef50_C1A3X2 Folylpolyglutamate synthase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A3X2_GEMAT Length = 430 Score = 189 bits (480), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 157/423 (37%), Positives = 211/423 (49%), Gaps = 40/423 (9%) Query: 20 LENLHSKT---IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 LE L ++T LGLERV+ + +RLG VF +AGTNGKG+T TL+++L AG Sbjct: 9 LERLFARTGGAWRLGLERVAELLSRLGDPHRRYPVFHIAGTNGKGSTVATLDALLRGAGR 68 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFK 136 KVG Y+SPHLV + ERV V G+ + +A T E ++ T+FE T AL F Sbjct: 69 KVGRYTSPHLVDFAERVVVNGEPMSHAAITEWLVTHEPLLTELGATFFEATTAMALSHFA 128 Query: 137 QAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEK 196 +DV I+EVGLGGRLDATNIV+ A VT I DH ++LG E+I EKAGIF+ Sbjct: 129 NEAVDVAIIEVGLGGRLDATNIVEPIAAAVTQIGFDHLEFLGDTLEAIAGEKAGIFKPGA 188 Query: 197 PAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS----DAHGT-------- 244 A+VG+ I D+ Q + + V VT DW DA GT Sbjct: 189 AAVVGDTR--PAIRDMLQARAEGVGSGPV----LVTGRDWQVDDIVVDAQGTSFTLAVAD 242 Query: 245 -----LENLPLPLVPQ---PNAATALAALRASG---LEVSENAIRDGIASAILPGRFQIV 293 L PLV Q NA+ ALA LR++G E+ NA R +A + GRF Sbjct: 243 GAGHHTRRLTTPLVGQFQAHNASVALALLRSAGGPWAEIERNASRY-LADVRIAGRFH-- 299 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 SP +FDVAHNP A + + A+ + AV+ +L DKD G L + + Sbjct: 300 -RSPPWLFDVAHNPDGAATVVANLLAVGVPHPLTAVVCVLRDKDWRGILQAVSRAAERIL 358 Query: 354 CAPLEGPRGATAEQLLEHLGNGKSFDSVAQAW---DAAMADAK-AEDTVLVCGSFHTVAH 409 L + + ++ Q + D A+++A+ TVLV GSFHTV Sbjct: 359 VTMAPTAPANRTWNLDDVMAWAEAEGLPVQRYDDFDRALSEAQVGAATVLVTGSFHTVGD 418 Query: 410 VME 412 ME Sbjct: 419 AME 421 >UniRef50_B4CZE0 FolC bifunctional protein n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4CZE0_9BACT Length = 408 Score = 188 bits (478), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 129/366 (35%), Positives = 186/366 (50%), Gaps = 27/366 (7%) Query: 16 WLSYLENLHSKTIDLGLERVSLVAA--RLGVLKP-APFVFTVAGTNGKGTTCRTLESILM 72 WL Y LH I LGLE + + ++ V P AP +AGTNGKG+ C L++ Sbjct: 9 WL-YASQLHG--IKLGLENIQRLVETLKIDVAGPRAPKFLHIAGTNGKGSVCAMLDACCR 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES--ARGDISLTYFEYGTLS 130 AAG + G+++SPHL+ + ER+R+ G+ + E+ +I + D T+FE T Sbjct: 66 AAGLRTGLFTSPHLITFRERIRLDGEMISEAEVAEGLTKIRTLAENWDHEPTFFEITTAL 125 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 AL F+ ++V+LE G+GGRLDATN+V V+T I LDH WLG +I REKAG Sbjct: 126 ALAWFQAKGAEIVVLETGMGGRLDATNVVSPVACVLTPIDLDHQQWLGESLGAIAREKAG 185 Query: 191 IFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 I + PA+ E+ + A+VA EK L+ + ++ A + +H Sbjct: 186 ILKQGVPAVSAPQADEVGAVFAEVATEKQVALEY----IPTPLAGYEVALAGSHQMW--- 238 Query: 249 PLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPH 308 NAA A+ AL +GL VSE AI G+ PGRFQ V R I D AHNP Sbjct: 239 --------NAALAVRALSLAGLPVSEEAIVRGLREVSWPGRFQHVQS--RFIIDGAHNPA 288 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 AA L + + + R ++G+L DKD+ G L + P+ PR AT+ ++ Sbjct: 289 AARRLATTWREVFGDKRASLILGVLRDKDVNGICEALLPIAGRILTVPVNNPRSATSMEV 348 Query: 369 LEHLGN 374 +G Sbjct: 349 ARAIGK 354 >UniRef50_Q1JY09 FolC bifunctional protein n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1JY09_DESAC Length = 430 Score = 188 bits (478), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 141/418 (33%), Positives = 203/418 (48%), Gaps = 25/418 (5%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 TP AA L +L L I LGLE + + +G + + VAGTNGKG+ C Sbjct: 2 NTPDAA------LEFLYGLQMFGIKLGLENIQTLVDSVGQPQRNYGIVHVAGTNGKGSVC 55 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L I AGY+VGVY+SPHL R+ ER+RV GQ + + A E+ ++ T+F Sbjct: 56 AFLGRIYRQAGYQVGVYTSPHLHRFNERIRVNGQPIDDHDLVALVDELRQKNSEVPATFF 115 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E+ T AL F + +D+VILEVG+GGRLDATN+V V+V+T ++ DH D+LG I Sbjct: 116 EFTTALALLYFARQNVDLVILEVGMGGRLDATNVVAPLVSVITPVSDDHGDYLGGSLAEI 175 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADV---AQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 EK GI + P ++G P+ + +A + A+E A G +++ T + Sbjct: 176 AAEKGGIIKPGVPVVIG-PQDKAAMAVLSARAKEMAAPCLCFGRDFSVEKTTSGCRVTTG 234 Query: 242 HGTLENLPLPLVP----QPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVS 294 L P +P N A AL L G +V++ +R+ +A PGR + V Sbjct: 235 ALCWSELQ-PSLPGRHQYDNLAVALMVVTHLAEQGWQVTQQVVREAVADTRWPGRLEWVG 293 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 E R++ D AHN A L ++ R+ V G DKD+ ++ L V YC Sbjct: 294 E--RILLDGAHNASGAHALADYLRGCNVQ-RIHWVAGFKADKDMEAVVSSLLPFVVQAYC 350 Query: 355 A--PLEG--PRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 P E PR L +H ++DS A +AA+ D V+V GS VA Sbjct: 351 VEPPTEQAYPRENVVVHLQQHGCEASAWDSPTVALEAALQQCGDHDLVVVAGSLFLVA 408 >UniRef50_C7N4J3 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N4J3_SLAHD Length = 427 Score = 188 bits (477), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 134/415 (32%), Positives = 215/415 (51%), Gaps = 19/415 (4%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 +YL + LGLER++ + RLG + A V +AGTNGKG+T IL AAG++ Sbjct: 14 AYLNQSSWTQVKLGLERITTLLERLGHPEQAYPVVHIAGTNGKGSTSAFTAGILQAAGFR 73 Query: 78 VGVYSSPHLVRYTERVRVQGQELPES-AHTASFAEIESARG-DISLTYFEYGTLSALWLF 135 G+++SP+++ + ER++V + + ++ H + A ++A G + T FE T A F Sbjct: 74 TGLFTSPYILEFNERIQVNRENIGDADLHDIALAVRQAADGLEEEPTPFELVTAVAFEYF 133 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 ++A+ D+V+LEVGLGGR DATN+ V +T IA+DH LG I EKAGI + Sbjct: 134 RRAECDIVVLEVGLGGRYDATNVTTPAVCAITPIAMDHVGVLGNTLAEIAGEKAGIIKPG 193 Query: 196 KPAIV--GEPEMPSTIADVAQEKGA-LLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 P + +PE + I A+ GA ++ R + + FS + + ++ L L Sbjct: 194 VPVVCYTQKPEAEAVIRAEARAIGAPVMTPRFGRIHARMEGLQQVFS--YDGINDVKLRL 251 Query: 253 VP--QP-NAATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 + QP NA A+ LR G ++++ I+ G+ PGRF++V+ P I D HN Sbjct: 252 LGAYQPCNAVMAIEIARTLRNQGFDIADEDIKRGLEETRWPGRFELVATDPVTIVDGGHN 311 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA-PLEGPRGATA 365 AE L ++ + V V+G+L DK + ++ + +YCA P E R +A Sbjct: 312 EQGAEVLADSLRRYFPDTPVTFVMGVLKDKQYPQMINYVVPLAKRFYCATPPESERALSA 371 Query: 366 EQLLEHLGNGKSFD-----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 E L + L + D S+A+A A A A +D V GS +++A +M ++ Sbjct: 372 EDLAQALREAGAADARPCASIAEAVQTARAQAGPDDVVCCFGSLYSIATIMAALE 426 >UniRef50_C7MLS9 Folylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Coriobacteriaceae RepID=C7MLS9_CRYCD Length = 466 Score = 188 bits (477), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 140/429 (32%), Positives = 211/429 (49%), Gaps = 36/429 (8%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 ++YL ++ LGLER+ + A LG + V VAGTNGKG+TC + S+L AGY Sbjct: 39 IAYLNEPRWRSSRLGLERIESLMAALGNPQDKLTVVHVAGTNGKGSTCAMVASVLQHAGY 98 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE--SARGDISLTYFEYGTLSALWL 134 + G+++SP+++ +T+R+R+ GQ + +A A+ + + + D T FE T A Sbjct: 99 RTGLFTSPYIIEFTDRIRIDGQNVSLAALCAATQTVRRVAEQMDDHPTEFELMTAVAFVC 158 Query: 135 FKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F A + ++EVGLGGRLD+TN++ A V + I+ DHTD LG I EKAGI + Sbjct: 159 FVAAGCTMAVVEVGLGGRLDSTNVIAAPAVCALAPISFDHTDILGSTLAQIAHEKAGIIK 218 Query: 194 SEKPAIVG---EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 AIV PE I + A + G+ + E S T +++ + +L + Sbjct: 219 -PGAAIVSALQRPEAMRVIENAALQVGSPVTVVD-EQRLSGTPAHFSYR----SYTDLSI 272 Query: 251 PL---VPQPNAATALAALRA---SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 PL NAA A+ A+ A G+ ++E +R+G+A PGRFQ+VS SP I D Sbjct: 273 PLKGSYQTHNAALAIEAIDALIQKGITITEQDLREGLAQVSWPGRFQVVSHSPEFIVDGG 332 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNP A+ L ++A R + +IG+L DKD+ L + C PR Sbjct: 333 HNPQGAQALVDSLEANYPARRTVLLIGVLADKDVTSMLRRVLPSGCGVVCITPPNPRALG 392 Query: 365 AEQLL------------------EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 A++L E L N S+ Q A A AE V GS ++ Sbjct: 393 AQELASQVVSLAKQLQNESIAIDERLLNPVCAPSIGQGVTCAQQMAGAEGLVCAFGSLYS 452 Query: 407 VAHVMEVID 415 +A +M +D Sbjct: 453 IADIMAALD 461 >UniRef50_A5FMS8 FolC bifunctional protein n=21 Tax=Bacteroidetes RepID=A5FMS8_FLAJ1 Length = 408 Score = 187 bits (476), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 122/392 (31%), Positives = 195/392 (49%), Gaps = 28/392 (7%) Query: 32 LERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTE 91 L + L+A LG + VAGTNGKG+T L S+L AGYKVG+Y+SPHL + E Sbjct: 29 LTNIKLLAEHLGNPEKKLQTIHVAGTNGKGSTSHMLASVLQEAGYKVGLYTSPHLKDFRE 88 Query: 92 RVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGG 151 R+++ GQE+ E A+ + +++FE A F + D+ I+EVGLGG Sbjct: 89 RIKINGQEITEDFVCEFIAKHKDFFEANDMSFFEMSVGLAFDYFAAEKTDIAIIEVGLGG 148 Query: 152 RLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PE-MPST 208 RLDATNI+ V+V+T+I LDHT +LG E+I EKAGI + P ++GE PE P Sbjct: 149 RLDATNIITPLVSVITNIGLDHTQFLGNTLEAIAGEKAGIIKPNVPVVIGEYTPETQPVF 208 Query: 209 IADVAQEKGALLQRRGVEWNYSVTD--HDWAFSDAHGTLENLPLPLVPQPNAATALAALR 266 +A K + + +D D+ F + + + + Sbjct: 209 LAKAEANKAPIYFASDLISEVFPSDLIGDYQFHNKKTVQQTIKI-------------VNE 255 Query: 267 ASGLEVSENAIRDGIASAI----LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPK 322 + ++S+ ++ G+ + + L GR+Q + E+P+++ D AHN H + +++ K Sbjct: 256 TTDFKISDENLKSGLLNTVKNTGLQGRWQQLGENPKIVCDTAHNKHGLSVVMNQLRN-EK 314 Query: 323 NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN----GKSF 378 ++ V+G+++DKD+ L ++C+P RG E L N G+ + Sbjct: 315 YEKLHIVLGVVNDKDLDSILPLFPKEAQYYFCSP-NSSRGLPTEVLQNAAKNFGLIGEKY 373 Query: 379 DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 DSV A+ A +A D + V GS VA + Sbjct: 374 DSVESAFAKAKQNASKNDFIYVGGSTFVVAEL 405 >UniRef50_D0MEF9 FolC bifunctional protein n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MEF9_RHOM4 Length = 442 Score = 187 bits (475), Expect = 6e-46, Method: Compositional matrix adjust. Identities = 138/406 (33%), Positives = 198/406 (48%), Gaps = 22/406 (5%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GLER+ + A +G A +AGTNGKG+T L +I AAGY+VG+++SPHL Sbjct: 24 GLERMGALLAAMGAPHRAYPCVHIAGTNGKGSTASLLAAIARAAGYRVGLHTSPHLWHVG 83 Query: 91 ERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLG 150 ER+R+ G P + + A + ++FE + F + Q+D+ ++EVGLG Sbjct: 84 ERMRIDGIPAPTTWLEKAVARCRPLFEQVQPSFFEATVALSFLYFAEQQVDLAVVEVGLG 143 Query: 151 GRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPST 208 GRLDATN+V +AV+TSI LDHTD LG E+I REKAGI + P + G +PE + Sbjct: 144 GRLDATNVVQPRLAVITSIGLDHTDILGETIEAITREKAGIIKPGVPVLTGVTQPEALAV 203 Query: 209 IADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG-----TLENLPLPLVPQPNAATALA 263 I + A + A L E + + F E+L + L + AA AL Sbjct: 204 IRETAARQQAPLHYLWEEVHLEQVAPETVFMRLTARTPARRYEDLEVGLPGRHQAANALL 263 Query: 264 ALRASGLEVSE---------NAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLT 314 A+RA+ L + E +RD + L GRF ++ P V+ DVAHNP + Sbjct: 264 AIRAAELVLPEVLDDPRPIRQGLRDVRQLSGLRGRFDVLQTRPLVVADVAHNPDGLAAVL 323 Query: 315 GRMKAL--PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL 372 + AL P GR A+ L DKD L Y A LE PR +A +L+ + Sbjct: 324 TTIDALHPPGTGRRYAIWSALRDKDAPTMAGQLVQAGFSVYVAALESPRAWSAVELVAMV 383 Query: 373 ----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 G +VA W +A+D +L+ GS VA + V+ Sbjct: 384 QQVGGQVPGVGTVASGWQLLQKRLQADDVLLITGSHQVVAALPPVL 429 >UniRef50_D0WG21 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Slackia exigua ATCC 700122 RepID=D0WG21_9ACTN Length = 442 Score = 187 bits (474), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 144/419 (34%), Positives = 211/419 (50%), Gaps = 21/419 (5%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 +YL+ + +DLGL+R + A LG + A + VAGTNGKG+T + IL AAGY Sbjct: 24 AYLQQGSWRDMDLGLDRTRALLAALGNPQDAYPIVHVAGTNGKGSTSAFIAGILQAAGYD 83 Query: 78 VGVYSSPHLVRYTERVRVQGQELP--ESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 G+++SP ++R+ ER++V ++ E A +A D+ T FE T AL F Sbjct: 84 TGLFTSPFILRFNERIQVNRVDISDGELDEVARAVRDAAASIDVHPTAFELITAVALEHF 143 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 ++ D V+LEVGLGGRLDATN+V +TSIA DH LG I EKAGI + Sbjct: 144 RRRGCDAVVLEVGLGGRLDATNVVVPAACAITSIAFDHMRILGDTLAQIAAEKAGIVKPG 203 Query: 196 KPAIVGE--PEMPSTIADVAQEKGALL--QRRGVEWNYSVTDHDWAFSDAHGTLENLPLP 251 P + PE + I D + G++L R G V ++ ++ + ++ L Sbjct: 204 VPVVSYRQAPEAQAVIEDACRAAGSVLVFPRFG---RIHVRQEGFSQVFSYDGIADVRLS 260 Query: 252 LVP--QP-NAATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 L+ QP NA A+ LR GL +S++AI+ G+ + PGRF++V+ SP I D H Sbjct: 261 LLGTYQPCNAVMAIEVARVLRTRGLAISDDAIKRGLETTRWPGRFELVAASPTTIVDGGH 320 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA-PLEGPRGAT 364 N A L ++A + V V GML DK +A + + YC P E R Sbjct: 321 NEQGAAMLASSLRAYFPHRTVTFVAGMLKDKRYRDMVALVAPLAAKVYCVEPPEPERALP 380 Query: 365 AEQLLEHLGNGKSFDSVAQAWDA-----AMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 A L + D+VA A A A A+A +D V GS ++++ VME + + R Sbjct: 381 AADLAQEFVRAGVADTVACASIADGVHRARAEASPDDVVCCFGSLYSISEVMEALGSSR 439 >UniRef50_C7JGW9 Bifunctional protein FolC n=8 Tax=Acetobacter pasteurianus RepID=C7JGW9_ACEP3 Length = 445 Score = 187 bits (474), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 151/419 (36%), Positives = 207/419 (49%), Gaps = 38/419 (9%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLG-VLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 L L NL+ IDL L R+ + A+LG + P V VAGTNGKG+TC TL +I AAG Sbjct: 21 LERLNNLYPALIDLSLGRLEALLAKLGHPEEKLPPVIHVAGTNGKGSTCATLRAIGEAAG 80 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 ++V V +SPHLV TER R+ G+ + ES A+ EIE +T FE T + LF Sbjct: 81 WRVHVMTSPHLVDVTERFRIAGKLVSESELVATLEEIEQVNDGAPITVFEVLTAAGFLLF 140 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIGREKAGIFRS 194 + D+ I+EVGLGGR DATN++ A +VTS++ DH +LG E+I EKAGIF+ Sbjct: 141 SRHPADMAIIEVGLGGRCDATNVLRKPAACIVTSVSRDHEAFLGDTLEAIAGEKAGIFKP 200 Query: 195 EKPAIVG-EPEMPSTIADVAQEK-GALLQRRGVEWNYSVTDH------DWAFSDAHGTLE 246 PA+ G +PE + +K GA L RRG EW+ S + + F+D G L Sbjct: 201 GVPAVTGNQPEAVMKVLQAQADKVGAPLYRRGAEWSISPQNDAESDTAELRFADKAGELT 260 Query: 247 NLPLPLVPQP---------NAATALAALRASGLEVSENAIRDGIASAILPGRFQ-----I 292 +PQP N A+ ALR SGL V E A + GI P R Q + Sbjct: 261 ------LPQPALVGAWQVENVGLAVEALRVSGLHVPEQAWQ-GIGRVNWPARMQQLHGKL 313 Query: 293 VSESP---RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTL-AWLKSV 348 S P + D HNP A L + A K+ + ++GM KD G L L Sbjct: 314 ASHLPEGWELWLDGGHNPGAGNALAQEL-AHWKDQPLHVLVGMKQTKDATGFLNPVLPFA 372 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLGNGKSFD-SVAQAWDAAMA-DAKAEDTVLVCGSFH 405 W + E ++E G ++ +A DA +A + + VL+CGS + Sbjct: 373 SSVWAICEPQQHLALPVEAIVEASGGKAQIGPTLVEALDALVAQNPQQHARVLICGSLY 431 >UniRef50_B8CY17 Folylpolyglutamate synthase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CY17_HALOH Length = 457 Score = 186 bits (473), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 138/426 (32%), Positives = 216/426 (50%), Gaps = 52/426 (12%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GL+R++ + + V VAGTNGKG+T L+SI AGY+VGVY+SPHL+ + Sbjct: 22 GLDRINALLGSFNHPEDRLKVIHVAGTNGKGSTIAFLKSIYTEAGYRVGVYTSPHLIHFN 81 Query: 91 ERVRVQGQELPESAHTASFAE----IESARGDISL---TYFEYGTLSALWLFKQAQLDVV 143 ER+ V + + + T +E +E + D + TYFE+ T AL F + +D+V Sbjct: 82 ERIEVGNRAISTAELTDLVSELVPRVEDLKKDPEVGGPTYFEFVTALALLYFARKDVDLV 141 Query: 144 ILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG- 201 +LEVGLGGRLDATN++ + V+V+TSI+LDHT LG D +SI REK+GI + + P + G Sbjct: 142 LLEVGLGGRLDATNVIKEPLVSVITSISLDHTSILGNDVKSIAREKSGIIKRDCPVVTGV 201 Query: 202 -EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD--------WAFSDAHGTLEN----- 247 E I + A+ K + L+ E++Y++ + + ++ +LE Sbjct: 202 RNKEALRVIEETAKLKNSPLKIIDKEYSYNIIESSLEGQSFTVFRLNNGDYSLEKEAESI 261 Query: 248 ---------LPLPLVPQ-PNAATALAALRASGLEVSEN--AIRDGIASAILPGRFQIVSE 295 + LP V Q NA A+A + + N I+ G+ASA +PGR ++++ Sbjct: 262 NGTEKIEYFIKLPGVYQVRNALLAMAVVDYLQEQYPVNLVQIKKGLASAFIPGRMEVLAR 321 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVI-GMLHDKDIAGTLAWLKSVVDDWYC 354 SP +I D AHN + L + L R +I G+L DKD+ G + L D+ Sbjct: 322 SPLIIADGAHNVEGVKKLVNSLGPLINEDRQFYIIVGILGDKDVEGMIEML-----DFGK 376 Query: 355 APLE-------GPRGATAE---QLLEHLG-NGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 A E R + E Q + G + + + + + DA+ ED + V GS Sbjct: 377 AKKELIITRNTNSRSCSPEVIGQYAQRRGIKYRVYPDLKTSLTGVLNDARPEDVICVTGS 436 Query: 404 FHTVAH 409 +TV+ Sbjct: 437 LYTVSE 442 >UniRef50_C6Y3V5 FolC bifunctional protein n=4 Tax=Sphingobacteriales RepID=C6Y3V5_PEDHD Length = 428 Score = 186 bits (472), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 129/384 (33%), Positives = 195/384 (50%), Gaps = 32/384 (8%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 V GTNGKG+T TL +I AGYK G+Y+SPHL + ER+R+ G +PE+ T + Sbjct: 51 VGGTNGKGSTSHTLAAIFQQAGYKTGLYTSPHLKDFRERIRINGTMVPETFVTDFVNRQK 110 Query: 114 SARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDH 173 IS ++FE A F + ++D+ I+EVGLGGRLD+TNI+ +++V+T+I+LDH Sbjct: 111 ETIEAISPSFFEVTVAMAFAYFAEEKVDIAIIEVGLGGRLDSTNIITPELSVITNISLDH 170 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPS-----TIADVAQEKGALLQRRGVEWN 228 T+ LG I EKAGI + P ++GE + S T A K + N Sbjct: 171 TNMLGNTLTEIATEKAGIIKPGIPVVIGEKQTESEAVFLTKASTTNSKIVFADQELSTTN 230 Query: 229 ------YSVTDHDWAFSDAHGTLENLPLPL---VPQPNAATALAA---LRASGLEVSENA 276 Y VT + ++L L L N T L A L+ G +++ A Sbjct: 231 TFREKEYLVTS---ILKNKILIYKDLQLDLNGIYQLKNILTVLQAVDILKNKGYTLNDKA 287 Query: 277 IRDGIASAI----LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGM 332 + + + L GR+Q +SE P VI D HN + + +K P ++ VIGM Sbjct: 288 LYTALKNVKTLTGLQGRWQKLSEHPLVICDTGHNMAGIKEVVQNLKETPFE-KLHIVIGM 346 Query: 333 LHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL-----LEHLGNGKSFDSVAQAWDA 387 + DKDI+G L L + ++C P + R A++L ++ L +G FD+V A +A Sbjct: 347 VKDKDISGVLTLLPTEAIYYFCQP-QLERALPAQELALQAKVQQL-HGNVFDTVTAALNA 404 Query: 388 AMADAKAEDTVLVCGSFHTVAHVM 411 A +A +D + + GS VA V+ Sbjct: 405 AKENAGKDDLIFIGGSNFVVAEVL 428 >UniRef50_B5EAK4 FolC bifunctional protein n=6 Tax=Geobacter RepID=B5EAK4_GEOBB Length = 424 Score = 186 bits (472), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 136/416 (32%), Positives = 208/416 (50%), Gaps = 14/416 (3%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 A LS++ L + GL R+S + A LG + V GTNGKG+T L SIL A Sbjct: 4 AETLSHIYALGRFGMKPGLSRISPLLAALGNPQERFRSVHVVGTNGKGSTASFLSSILSA 63 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALW 133 GY+ G+++SPHL+ +TER+R+ G E+ + A + +A S T+FE T A+ Sbjct: 64 GGYRTGLFTSPHLISFTERIRIDGNEISQEDVVLVAARVMAAAPPES-TFFEIVTALAVL 122 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F + ++V + E G+GGRLDATN +D + VT I+L+HT++LG I +EKAGI + Sbjct: 123 YFAEKGVEVAVFEAGMGGRLDATNALDGILCAVTPISLEHTEYLGETLAEIAQEKAGICK 182 Query: 194 SEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLP 251 P + ++ + IA A E G+ L R+ ++ + TL++L + Sbjct: 183 PGAPLVSASQHADVEAAIATRADEIGSPLYRQQESFDAFWQGERLCYRGIGVTLDDLKVG 242 Query: 252 LVPQPNAATALAALRAS------GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 L + A AL + G + A+ G+A A PGR ++ PRV+ D AH Sbjct: 243 LFGRYQRGNAALALAVAELLGGLGFPLPPQAMAAGMARAFWPGRMELFPGPPRVLLDGAH 302 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATA 365 NP A L + +P+ R+ V+G++ DK++ G L L + D +C R A Sbjct: 303 NPAGANALAEALAEVPR-ARLFMVVGVMGDKELGGILGPLLPMADQVFCVTPALERALPA 361 Query: 366 EQLLEH-LGNG---KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 E++ L G + SV Q A + A ED +LVCGS TV + +R Sbjct: 362 EEIARFCLAAGVPAQEAGSVTQGVQQAQSAAADEDLILVCGSLFTVGEARGYLLSR 417 >UniRef50_D0GKP2 Tetrahydrofolate synthase n=1 Tax=Leptotrichia goodfellowii F0264 RepID=D0GKP2_9FUSO Length = 426 Score = 186 bits (471), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 112/415 (26%), Positives = 207/415 (49%), Gaps = 41/415 (9%) Query: 31 GLERVSLVAARLGVLKPAPF--VFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVR 88 ++ + L+ LG KP + +AGTNGKG+T +E+IL AAGY V ++SPH+++ Sbjct: 21 NIDDLKLIYDLLG--KPCKNNKIIHIAGTNGKGSTASFIENILTAAGYSVCKFTSPHILK 78 Query: 89 YTERVRVQGQELPESAHTASFAEIE--------SARGDISLTYFEYGTLSALWLFKQAQL 140 Y ER+ + + +++ I+ S +I+L +FE T AL F++ Sbjct: 79 YNERIVSDKKMITNEEILQNYSIIKGTVSNYNKSGSNEINLNFFEITTFIALLYFQKQNP 138 Query: 141 DVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV 200 D ++LE GLGGRLDATNIVD++++V+T+I DH + LG + I EKAGI ++ + I Sbjct: 139 DFIVLETGLGGRLDATNIVDSNISVITNITFDHVNILGNTLQQIAYEKAGIIKNGELCIY 198 Query: 201 GE--PEMPSTIADVAQEKGALLQR-RGVEWNYSVTDHDWAFSDAHGTLEN--LPLPLVPQ 255 + PE+ I + ++++ + +E ++ EN LPL + Sbjct: 199 SDNLPELKKEIDKKTSKAINVIEKYKNIEIELDKKNYKTVLY-----FENKRFILPLFGK 253 Query: 256 PNAATALAALRASGL-EVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLT 314 A L A + + + + I+ G+ + P RF+ S++P +I D AHN + + L+ Sbjct: 254 FQAYNFLIAYEIAKIYNIHDKVIQKGLDNVYWPARFEFYSKNPTIILDAAHNDDSIKKLS 313 Query: 315 GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-PRGATAEQLLEHLG 373 +K L K V+ + +L KD + L+++ D + L+ G T++++ + + Sbjct: 314 ENLKELYKKNEVIIITSLLQTKDFKAVFSELQNISDKIFITSLKNVAYGLTSQEIKDKMK 373 Query: 374 N--------------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 K++ + + + + KA ++VCGSF+ ++ +++ Sbjct: 374 ELNISVENIIFEDDINKAYKESLKLLNNTIYNFKA---IIVCGSFYEISEFEKIV 425 >UniRef50_Q1GD59 FolC bifunctional protein n=6 Tax=Alphaproteobacteria RepID=Q1GD59_SILST Length = 423 Score = 185 bits (470), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 145/417 (34%), Positives = 198/417 (47%), Gaps = 29/417 (6%) Query: 17 LSYLENLHSKTIDLGLERV-SLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 L+ + LH K IDL L+RV L+AA P V +AGTNGKG+T + + L G Sbjct: 10 LARMMALHPKIIDLTLDRVWRLLAALENPQDKLPPVIHIAGTNGKGSTQAMIRAGLEGWG 69 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 V Y+SPHL R+ ER+R+ G + E+ T E SA GD S+TYFE T++ L F Sbjct: 70 KSVHAYTSPHLARFHERIRLAGDLISEAHLTEVLDECYSANGDASITYFEITTVAGLLAF 129 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 + D +LEVGLGGRLDATN++ +V+V+T +++DH +LG I EKAGI + Sbjct: 130 SRTPADYTLLEVGLGGRLDATNVITPEVSVITPVSIDHEQFLGNTLAKIAGEKAGIIKRG 189 Query: 196 KPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV 253 P +VG E I D A GA L G W+ + D G L +LPLP + Sbjct: 190 VPVVVGPQAEEAMEVIEDTAMRLGAPLIAYGQHWHVHEERGRLVYQDERGLL-DLPLPNL 248 Query: 254 ----PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI--------F 301 NA ALA LR G + E A + A P R Q + P V Sbjct: 249 MGAHQIQNAGAALAVLRHLGAD--EAACEAAVVGAQWPARMQRLKTGPLVEIAGAAELWL 306 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D HN A L + LPK L + GML+ KD+ G L L + + G Sbjct: 307 DGGHNAAAGIALADVLAKLPKRPTHL-ICGMLNTKDVTGYLRPLAAEAQSLTAVSIPGEA 365 Query: 362 GATAEQLLEHLGNGKSFD-------SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 + + E S D SVA+A A +A + VL+CGS + +++ Sbjct: 366 ATLSAE--ETKAAASSVDLPATTAESVAEALTAILAR-DPDSRVLICGSLYLAGNIL 419 >UniRef50_D1PA28 Tetrahydrofolate synthase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PA28_9BACT Length = 412 Score = 185 bits (470), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 119/409 (29%), Positives = 210/409 (51%), Gaps = 34/409 (8%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 E + +K GL+ + + G +AGTNGKG++ TL +IL + GYKVG Sbjct: 17 FEKIGAKAYKPGLDTMYKMDEHFGHPHNQYKCIHIAGTNGKGSSSHTLAAILQSQGYKVG 76 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD-ISLTYFEYGTLSALWLFKQA 138 +++SPHLV + ER+R+ G+ + E + F E + + ++FE T+ A F + Sbjct: 77 LFTSPHLVDFRERIRINGEMVSEE-YVIDFVENNRKFFEPLHPSFFELTTMMAFQYFAEQ 135 Query: 139 QLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPA 198 ++D ++EVGLGGRLD+TNI+ ++V+T+I+ DHT +LG I EKAGI + Sbjct: 136 KVDFAVIEVGLGGRLDSTNIITPILSVITNISFDHTQFLGNTLGEIAGEKAGIIK----- 190 Query: 199 IVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV-----TDHDWAFSDAHGTLENLPLPLV 253 P++P I + +E + ++ E N + TD D F + G + + Sbjct: 191 ----PKIPVVIGEWNEETQPVFIKKAHEQNSPIHFAHETDADMNF-ELKGNYQKKNFCTI 245 Query: 254 PQPNAATALAALRASGLEVSENAIRDGIASAI----LPGRFQIVSESPRVIFDVAHNPHA 309 + A+ L+ G+E+ + +I++G L GR++ ++E P I D HN Sbjct: 246 -----SAAVECLKEEGIEIKDQSIKNGFEHVCELTGLRGRWEKLNEHPLTICDTGHNLAG 300 Query: 310 AEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD---WYCAPLEGPRGATAE 366 EYL ++ ++ + + + V GM+ DKD+ + L+ + + +Y R + Sbjct: 301 WEYLEPQIASVKADTKHI-VFGMVDDKDVEHVMELLEKLPKESTIFYWTQPSTKRAIPVD 359 Query: 367 QLL----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 +L +H NG + ++AQA++ A A+AK +D + + GS + VA ++ Sbjct: 360 KLFGYAQKHGLNGTCYQTIAQAFNTAKANAKKDDFIFIGGSSYVVADLL 408 >UniRef50_B8FMP6 FolC bifunctional protein n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FMP6_DESAA Length = 444 Score = 185 bits (470), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 131/412 (31%), Positives = 204/412 (49%), Gaps = 36/412 (8%) Query: 28 IDLGLERVSLVAARLGVLKPAPFV--FTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPH 85 I LGLE +++A G+ P + +AGTNGKG+ + SIL AAGYKVGVY+SPH Sbjct: 22 IKLGLE--TILAMLKGIGDPHLRIQCIHIAGTNGKGSVAQNTASILQAAGYKVGVYTSPH 79 Query: 86 LVRYTERVRVQGQELPESAHTASFAEIESARG-DISLTYFEYGTLSALWLFKQAQLDVVI 144 LV ER V G+ + + ++ ++S G + T+FEY T AL+ F +A +D + Sbjct: 80 LVHINERFTVNGRPISDDEVLEAYQAVKSVSGLERHATFFEYTTAMALYAFDRAGVDYAV 139 Query: 145 LEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--E 202 +E G+GGRLDATN++ ++ ++T+I+++H +LG I EKAGI + P + G + Sbjct: 140 METGMGGRLDATNVLKPELCIITNISVEHEMYLGNTIAQIAYEKAGIIKPGVPVVTGVRQ 199 Query: 203 PEMPSTIADVAQEKGALLQRRGVE----------WNYSVTDHDWAFSDAHGTLENLPLPL 252 P+ + A E A L R G + +N+ DH W + L L Sbjct: 200 PDAIKAVEKAAAESKAPLYRMGKDFKTRRLQGGGFNFYGQDHAW---------KGLQCRL 250 Query: 253 VPQ---PNAATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 + PNA+ ALA AL G +++E + G+ PGR + + ESP VI D AHN Sbjct: 251 KGEYQIPNASLALAGCQALTKRGAKITEEQAKAGLEQVKWPGRLETIQESPMVILDGAHN 310 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 A + LT + + V + G L DK L L+++ + R + Sbjct: 311 LAAMKVLTKYLAETFADRDVTVITGFLDDKPYKKMLPMLEALAAKIIITRPKIGRAVETK 370 Query: 367 QLLEHLGNGK----SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 +L + N K SV +A A+ +A+ D ++V GS + V + + Sbjct: 371 ELTPLIRNKKDRFVEKPSVEEAVKYALENARDTDVIVVAGSLYIVGEARQTL 422 >UniRef50_B9XQF6 FolC bifunctional protein n=1 Tax=bacterium Ellin514 RepID=B9XQF6_9BACT Length = 435 Score = 185 bits (470), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 144/419 (34%), Positives = 203/419 (48%), Gaps = 27/419 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + +L NL LGLE +A G + VAGTNGKG+TC LESI AG Sbjct: 7 IQFLYNLQVFGTKLGLENTYRLAKLAGNPQEKLRFIHVAGTNGKGSTCAMLESIYRHAGL 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR----GDISLTYFEYGTLSAL 132 KVG+++SPHLV + ER+++ + + E E+++ D T+FE T+ AL Sbjct: 67 KVGLFTSPHLVAFGERIQINRELISEEEIIRLVEEMKALLQEFPADEHPTFFEVVTIMAL 126 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F + + DVVI E GLGGRLDATNIV V+V+T+I DH WLG I EKAGI Sbjct: 127 SYFARQKCDVVIWETGLGGRLDATNIVTPLVSVITNIQFDHQKWLGDTLAKIAFEKAGII 186 Query: 193 RSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 + P I V +PE + AQEK A +S+ WA ++ H ++ L L Sbjct: 187 KPRVPVITAVDDPEALRILFKTAQEKAA---------PFSLI--TWAQTEFH-PMQGLTL 234 Query: 251 PLV---PQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSES--PRVIFDV 303 PL+ + NAATA+ A+ A S + VS+ IR G++ PGR Q+V +V+ D Sbjct: 235 PLLGEHQRLNAATAVHAVMAARSCIPVSDETIRKGLSGVKWPGRLQLVERKNGQKVLLDG 294 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 AHN +AE L + R V+G+L DKD + + P+ R Sbjct: 295 AHNIGSAEALKTALNTYFATRRPTLVMGILSDKDAHPMCEIIAPLAGRILLVPVNSQRTI 354 Query: 364 TAEQLLEHLGNGKSFDSVAQAWDAAMA-DAKAEDT-VLVCGSFHTVAHVMEVIDARRSG 420 +L+ V + A D AED V V GS + + ME++ +G Sbjct: 355 LPRELIPVCRRANPDVEVRECRSLKEALDVAAEDPFVAVTGSLYLIGEAMELLGLSPAG 413 >UniRef50_B8DZV7 FolC bifunctional protein n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8DZV7_DICTD Length = 443 Score = 184 bits (468), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 144/427 (33%), Positives = 209/427 (48%), Gaps = 41/427 (9%) Query: 13 LASWLSY---LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 L S+++Y L+N+ + LER+ + +G + F VAGT GKG+T + S Sbjct: 10 LNSFINYEKRLDNITYEEKKFYLERMRYLLKLMGNPQDNLQAFHVAGTKGKGSTSAMIFS 69 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQ----GQELPESAHTASFAE--IESARGDISL-- 121 IL AGYKVG+Y+SPHL ER+ QE E +A+ IE A+ Sbjct: 70 ILKEAGYKVGLYTSPHLQSIRERISTHKGFISQE--EFIDLIDYAKPYIEEAKKHPIFGP 127 Query: 122 -TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 T+FE T A F +LD V++EVGLGGRLDATN+++ V+++T I DH LG Sbjct: 128 PTFFEVLTALAFLYFYIKKLDYVVIEVGLGGRLDATNVINPLVSIITPIGFDHMHILGNT 187 Query: 181 RESIGREKAGIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQR--RGVEW---NYSVTD 233 E I EKAGI + K I + + E IA VA+E+ A+ + +W ++S+ Sbjct: 188 IEKIAFEKAGIIKEGKFVISSIQKEEAEKVIAKVAKERNAIYYKIDNLFKWERKDFSLNG 247 Query: 234 HDWAFSDAHGTLENLPLPLVPQP---NAATALAA--LRASGLEVSENAIRDGIASAILPG 288 + S E +PL+ + NA TA A L L + +R+G G Sbjct: 248 QRFLLS-GKDINEEFFIPLLGEHQIVNAITAFGAIYLLRDKLSIDYETVREGFKKVQWMG 306 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 RFQIVS+SP I D AHN +A L +K R+ + G++ DKD G L L + Sbjct: 307 RFQIVSKSPLTIIDGAHNVESAIALRDTLKNYVNFNRLFLICGLMKDKDAEGFLKILNPL 366 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLGN-GKSFDSVA---------QAWDAAMADAKAEDTV 398 V + PL R + E+ LGN KSF++ A +A + +A ED + Sbjct: 367 VYSYNFVPLSSHRTRSPEE----LGNIVKSFNADANINLHTNFYEAINFVKKEASPEDLI 422 Query: 399 LVCGSFH 405 L+ GS + Sbjct: 423 LITGSLY 429 >UniRef50_B5ZCR5 FolC bifunctional protein n=2 Tax=Gluconacetobacter diazotrophicus PAl 5 RepID=B5ZCR5_GLUDA Length = 432 Score = 184 bits (467), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 137/344 (39%), Positives = 181/344 (52%), Gaps = 21/344 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLG-VLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 L L L+ IDL L R+ + ARLG + P V VAGTNGKG+TC TL +I AG Sbjct: 18 LERLNRLYPALIDLSLGRLQALLARLGHPERHLPPVIHVAGTNGKGSTCATLRAIGEQAG 77 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 + V V +SPHLV TER RV G + A A EIE +T FE T + LF Sbjct: 78 WPVHVMTSPHLVDVTERFRVAGHIVSTDALVAVLEEIERVNDGAPITVFEVLTAAGFLLF 137 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAV-VTSIALDHTDWLGPDRESIGREKAGIFRS 194 + + I+EVGLGGR DATN+++ A +TSI++DH +LG +I EKAGI + Sbjct: 138 ARHPARLAIIEVGLGGRFDATNVLEKPAACAITSISMDHEAFLGDSLAAIAAEKAGIMKP 197 Query: 195 EKPAIVG---EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLP 251 P + G E M A AQ GA L+ RG +W+ + T ++DA G L +LPLP Sbjct: 198 GVPVVTGRQAEAAMAVLRAQAAQ-CGAPLRVRGEDWDIAATPGGLRYTDARGAL-DLPLP 255 Query: 252 LVPQP----NAATALAALRASGLEVSENAIRDGIASAILPGRFQ--------IVSESPRV 299 +P NA A+AALRASGLEV ++A GIA + P R Q ++ + Sbjct: 256 GLPGAHQIDNAGLAVAALRASGLEVPDSAW-AGIAHTVWPARMQRLGGALAGLLPPEWEL 314 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA 343 D HNP A + L + + V V+GM KD AG L+ Sbjct: 315 WLDGGHNPGAGQALADVLAGW-SDRPVHLVVGMKQTKDAAGFLS 357 >UniRef50_Q5CB75 Folylpolyglutamate synthase/dihydrofolate synthase n=11 Tax=Thermotogaceae RepID=Q5CB75_THESQ Length = 437 Score = 184 bits (466), Expect = 7e-45, Method: Compositional matrix adjust. Identities = 133/420 (31%), Positives = 207/420 (49%), Gaps = 22/420 (5%) Query: 15 SWLSYLENLHSK----TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 ++L L+ L+ K + GLER+S++ ++LG V GTNGKG+ + I Sbjct: 9 AYLEVLKYLYHKRPMGKVKPGLERISMLLSKLGNPHLKYKSIHVGGTNGKGSVTNMISHI 68 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYF 124 L++ GY+VG Y SPHL + ER+R+ + + E + ++E ++ S ++F Sbjct: 69 LISQGYRVGSYYSPHLSTFRERIRLNEEYISEEDVVKIYEKMEPILNELDKEEIFSPSFF 128 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T A F + +D+ +LEVGLGGRLDATN+V + + ++ DH LG E I Sbjct: 129 EVVTAMAFLYFAEKNVDIAVLEVGLGGRLDATNVVFPLCSTIVTVDRDHEKTLGYTIEQI 188 Query: 185 GREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTD---HDWAFS 239 EK+GI + P + GE E + DVA++K + + +++ V H+ F Sbjct: 189 AWEKSGIIKERVPLVTGERKREALKVMEDVARKKSSRMYVIDKDFSVKVKSLKLHENRFD 248 Query: 240 DA-HGTLENLPLPLV-PQ--PNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSE 295 T E+L L + P NA AL L A+GL +SE AIR+G+ +A GRF+I+ + Sbjct: 249 YCGENTFEDLVLTMNGPHQIENAGVALKTLEATGLPLSEKAIREGLKNAKNLGRFEILEK 308 Query: 296 SPRV-IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 + I D AHNPH AE L +K + + VIG+L DK+ L + + Sbjct: 309 DGKTYILDGAHNPHGAESLVRSLKLYFNDKPLNLVIGILDDKNREDILRKYTGIFERVIV 368 Query: 355 APLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 + PR L++ K F +V D A +E +V GS V +V E + Sbjct: 369 TCVPSPRMKDMNSLVD--TAKKFFKNVEVIEDPLEAIESSEGDTVVTGSLFLVGYVREFL 426 >UniRef50_Q01UR3 FolC bifunctional protein n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q01UR3_SOLUE Length = 422 Score = 184 bits (466), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 145/407 (35%), Positives = 205/407 (50%), Gaps = 34/407 (8%) Query: 26 KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPH 85 KT LGLER++ V LG + VAGTNGKG+TC +ES L A+G G+++SPH Sbjct: 18 KTAKLGLERIARVLEALGNPHRRTRIVHVAGTNGKGSTCAMIESGLRASGRSTGLFTSPH 77 Query: 86 LVRYTERVRVQGQELPESAHTASFAEIESARG--------DISLTYFEYGTLSALWLFKQ 137 L TER+R+ G + +A+F + +A D+ TYFE T A +F + Sbjct: 78 LAEPTERIRINGVPVSAERFSAAFDRVHAAVEQLLAVNAIDLHTTYFETVTAMAFLIFAE 137 Query: 138 AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKP 197 +D+V+LEVGLGGRLDATN+V ++ V+T + DH +LG + I EKAGI ++ P Sbjct: 138 EAVDIVVLEVGLGGRLDATNVVLPELCVITPVDFDHEAFLGRSLQEIAGEKAGILKAGVP 197 Query: 198 AIVGEPEM-PSTIADVAQEKGALLQRRGVEWNYS--VTDHDWAFSDAHGTLE-NLPLPLV 253 A+ S + D + ++ R V W V D + G + ++ PL Sbjct: 198 AVFARQRAEASAVLDQRAAQLSIPIARTVAWPVDDLVLDSRGSRFLLSGERDLHIACPLA 257 Query: 254 PQ---PNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 + NAATA AL + L VS+++I GIA PGR + VSE P +I D AHNP A Sbjct: 258 GEHQVENAATAAIAL--TRLGVSDHSIETGIAQTRWPGRLERVSEHPEIILDGAHNPAGA 315 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDK---DIAGTLAWLKSVVDDWYCAPLEGPRGATA-- 365 L ++ RV + G + DK +IAG L L V L PR A A Sbjct: 316 RALAAYIERFYAGRRVRLIYGAMRDKAIDEIAGILFPLAHQV------ILTAPRQARALA 369 Query: 366 ----EQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 ++ +H + D +AQA A + DA + D V + GS VA Sbjct: 370 PEAIREIADHPDVQVAPD-LAQAI-ALLCDAASNDAVFITGSLFLVA 414 >UniRef50_A5TUM3 Tetrahydrofolate synthase n=15 Tax=Fusobacterium RepID=A5TUM3_FUSNP Length = 415 Score = 183 bits (465), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 115/395 (29%), Positives = 198/395 (50%), Gaps = 13/395 (3%) Query: 27 TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 +I LGL+ + + LG + + V + GTNGKG+ T+E IL+ AGYKVG Y+SPH+ Sbjct: 21 SIRLGLDNIKEICKYLGNPEKSYKVIHITGTNGKGSVSTTVERILLDAGYKVGKYTSPHI 80 Query: 87 VRYTERVRVQGQELPESAHTASFAEIESA--RGDISLTYFEYGTLSALWLFKQAQLDVVI 144 +++ ER+ + + + + ++ +I T+FE T FK + D VI Sbjct: 81 LKFNERIIFNDKYISDENVAKYYERVKKIIDEHNIQATFFEVTTAMMFDYFKDMKADYVI 140 Query: 145 LEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE-- 202 LE G+GGR DATN+ D V+V+T+++L+HT++LG I +EKAGI ++ I + Sbjct: 141 LEAGMGGRYDATNVCDNIVSVITNVSLEHTEYLGDTIYKIAKEKAGIIKNCPYTIFADNN 200 Query: 203 PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATAL 262 P++ I + + +L++ + YS+ D + ++ L L Sbjct: 201 PDVKKAIEEATDKYVNVLEKYR-DSTYSL-DFNTFTTNILINGNKYEYSLFGDYQYKNFL 258 Query: 263 AALR-ASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALP 321 A L + EN I++ + I RF++ S++P VIFD AHN E L +K Sbjct: 259 CAYEVVKYLGIDENIIKEAVKKVIWQCRFEVYSKNPLVIFDGAHNLAGVEELIKIVKQHF 318 Query: 322 KNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQLLEHLGNGKSFDS 380 V ++ +L DKD L + + + + PR +TA++L +++ N K F+ Sbjct: 319 SKDEVTILVSILKDKDRVSMFRKLNEISSNIVLTSIPDNPRASTAKELYDYVENKKDFEY 378 Query: 381 VA---QAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 +A++ A+ +K + CGSF+ + + E Sbjct: 379 EEDPIKAYNLAL--SKKRKLTICCGSFYILIKLKE 411 >UniRef50_Q2JLQ4 Folylpolyglutamate synthase n=2 Tax=Synechococcus RepID=Q2JLQ4_SYNJB Length = 433 Score = 183 bits (464), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 144/424 (33%), Positives = 215/424 (50%), Gaps = 31/424 (7%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 P W ++LE+L +DL LER+ ++ RLG + VAGTNGKG+ C + +L Sbjct: 9 PDWDWPAFLESLGHFGVDLSLERMQVLLQRLGQPQAGIPAIHVAGTNGKGSVCAWVSHVL 68 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-----ARGDISLTYFEY 126 AAGY+VG Y+SPHLV + ER+ + G+ + + + + A++ A + S T FE Sbjct: 69 WAAGYRVGRYTSPHLVDWRERIWLNGEYISANDWSQALAQVRDCLQTYAPDEASPTQFEV 128 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNI-VDADVAVVTSIALDHTDWLGPDRESIG 185 T +A F++ ++DV ++EVGLGGRLDATN ++ V +TSI DH LG I Sbjct: 129 ITAAAWLYFRRQKVDVAVIEVGLGGRLDATNAGIEPVVTAITSIGWDHWQRLGNSLPQIA 188 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTI-ADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 EKAGI + PA+ PE+ + I A Q + L ++W+ T H W Sbjct: 189 SEKAGILKPGIPAVCAPQTPEVTAVIRAKAEQLRSPLRVVDPLQWSEPQTVH-W-----R 242 Query: 243 GTLENLPLP-LVPQPNAATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 G L LPL V NAA ALA L+ G +++ A+ G A PGR Q V R Sbjct: 243 GQLLTLPLSGDVQLTNAAVALAVVETLQQQGWRIADAAVEKGFAITRWPGRLQRVQIGSR 302 Query: 299 -VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 ++ D AHN AA+ L R + G + +G+L KD+ G L+ L D ++ P+ Sbjct: 303 QLLMDGAHNLPAAQALR-RYLDEHQPGPLTWYVGILTTKDVQGILSTLLRPGDCFFALPI 361 Query: 358 EGPRGATAEQLLE-------HLGNGKSFDSVAQAWDAAMADAK--AEDTVLVCGSFHTVA 408 G G EQL + HL + + +++ A A + K E ++CGS + + Sbjct: 362 AGHSGTDPEQLAQLAQTLQPHLASARELPNLS-ALRAQLLKPKNLTELPAVICGSLYLLG 420 Query: 409 HVME 412 VM+ Sbjct: 421 QVMQ 424 >UniRef50_A8SN77 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SN77_9FIRM Length = 425 Score = 182 bits (462), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 116/403 (28%), Positives = 195/403 (48%), Gaps = 16/403 (3%) Query: 28 IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLV 87 + LGL+ + + +LG + + +AGTNGKG+ + S+L++ GYKVG+++SP + Sbjct: 18 VKLGLQNIKNLMEKLGNPQDKLKIIHIAGTNGKGSCTSFVNSVLVSQGYKVGMFTSPSIY 77 Query: 88 RYTERVRVQGQELPESAHTASFAEIESARGDISL--TYFEYGTLSALWLFKQAQLDVVIL 145 + ER+R+ + +PE E+ + + FE T A F + D I+ Sbjct: 78 NFEERIRINNKNIPEDKLIELMNEVREIANTLEVFPADFELVTALAFLYFYRENCDFAIM 137 Query: 146 EVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV--GE 202 EVGLGGRLDATN+++ + ++TSI+ DH +LG + I EKAGI + P ++ + Sbjct: 138 EVGLGGRLDATNVINKPLITLITSISFDHQQFLGNTIKEIALEKAGIIKDGVPLVLYSQD 197 Query: 203 PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATA- 261 E+ I VA+ K + + + + + + +NL + L+ A Sbjct: 198 TEIMDNIMGVAKSKNSKVIVNDLSKIKVLENKKSGQVIDYKDFKNLKINLLGSHQVKNAT 257 Query: 262 -----LAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGR 316 L LR G E+S +I +G ++ P RF++VS+SP I D AHN E Sbjct: 258 ISLELLLELRKIGFEISNESIYNGFSTVTWPCRFELVSKSPDFILDGAHNIDGIEKFVSN 317 Query: 317 MKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL---LEHLG 373 M KN + +A+ G+L DKD L + D + + R A +L +E L Sbjct: 318 MNFYYKNNKKIAIFGVLADKDYNEMLEKIVPCFDVFLTVRPDSERAMEAYELKEKIEALT 377 Query: 374 NGK--SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 K SF++ +A D A + +D + GS + V + +++ Sbjct: 378 EKKVYSFENYQEAIDKAFEISSKDDVISAFGSLYFVGEIRKLL 420 >UniRef50_D2QCN6 FolC bifunctional protein n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QCN6_9SPHI Length = 428 Score = 181 bits (460), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 140/429 (32%), Positives = 208/429 (48%), Gaps = 28/429 (6%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 +A L S L + K I GL L+ LG VAGTNGKG+T L Sbjct: 5 EAIDYLYSRLPVFHRIGPKAIKPGLGNTLLLCEGLGNPHQQFTSIHVAGTNGKGSTSHML 64 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 +I +AGY+VG+Y+SPHL +TER+R+ G+ +PE + + + ++FE Sbjct: 65 AAIYQSAGYRVGLYTSPHLKSFTERIRLNGRPIPEEEVVRFVEQQQPLIESVEPSFFEVT 124 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 A + F + +D+ I+EVGLGGRLD+TN++ +V+T+I DHTD LG I E Sbjct: 125 VAMAFYFFARHAVDIAIIEVGLGGRLDSTNVITPIASVITNIGYDHTDILGDTLPLIAAE 184 Query: 188 KAGIFRSEKPAIVGE--PEMPSTIADVA---QEKGALLQRRGVEWNYSVTD----HDWAF 238 KAGI + P I+GE PE V+ Q R+ + + + D + Sbjct: 185 KAGIIKPGVPVIIGESHPETQEVFTSVSASLQAPITFADRQYLVNDLGLVDGIRQASISR 244 Query: 239 SDAHGTLENLPL----PLVPQPNAATALAALRASGLEVSENAIRDGIASAI----LPGRF 290 D G L L L L P + L+ V+ ++G+AS L GRF Sbjct: 245 GDGSGWLAQLDLLGAYQLKNLPGVFATVEQLQQQ-FPVTAAQQQEGLASVSLLTGLKGRF 303 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALP-KNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 Q + PRVI D AHN E L ++++P K R+ +IG++ DKD + L+ L + Sbjct: 304 QTLGSHPRVIADTAHNQPGLEALFDTIRSIPYKTLRI--IIGLVADKDRSKVLSVLPTNA 361 Query: 350 DDWYCAPLEGPRGATAEQLLEH----LGN-GKSFDSVAQAWDAAMADAKAEDTVLVCGSF 404 ++C PR +A QLL+ LG G F V A AA+ A +D +L+ GS Sbjct: 362 VYYFCQA-NTPRSLSA-QLLQQEARVLGRIGDVFTDVNTALAAALEQADPDDLLLITGSN 419 Query: 405 HTVAHVMEV 413 +T+A + + Sbjct: 420 YTIAELTNL 428 >UniRef50_A6TN35 FolC bifunctional protein n=2 Tax=Alkaliphilus RepID=A6TN35_ALKMQ Length = 439 Score = 181 bits (459), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 128/421 (30%), Positives = 200/421 (47%), Gaps = 30/421 (7%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L+Y+ + + LGL+ + + L V VAGTNGKG+ + S+L GY Sbjct: 7 LTYIHDTYKFGRKLGLDNIKYLLNLLDNPHQKVKVIHVAGTNGKGSIASLIHSVLKTQGY 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEYGTLS 130 +VG+Y+SP+L +TER+R+ G+++P E++ G T FE T Sbjct: 67 RVGLYTSPYLEEFTERIRISGEDIPRERLAQVTEEVKMKIEEMVKSGQNHPTEFEVVTAI 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESIGREKA 189 A + Q ++D V+LEVGLGGRLDATN+++ + +++T I DHT +LG + I EK Sbjct: 127 AFLYYAQEEVDFVVLEVGLGGRLDATNVINTPLLSIITPIGYDHTAYLGNTLKEIAFEKG 186 Query: 190 GIFRSEKPAIVG--EPEMPSTIADVAQEKGALL---QRRGVEWNYSVTDHDWAFSDAHG- 243 G+ + + +V E E + ++QE+ L +G+E S + + + Sbjct: 187 GVIKEDGLTLVAPQEEEALQVLKKLSQERNNQLFMTNLQGLEIKKSTIEEQVFSCETYAR 246 Query: 244 TLENLPLPLV---PQPNAATALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSES 296 EN+ + L+ N TAL A+ +EVS+ +I GI PGR ++V + Sbjct: 247 AYENVEIKLLGAHQIENCCTALTAIDILKEHHDIEVSDESIYQGILETRWPGRMEVVQDE 306 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P VI D AHN + L +K L R+ V+GML DK++ G L L +VD Sbjct: 307 PTVIIDGAHNLQGGQALANTLKQLLSGRRITFVMGMLEDKEVDGFLNELIPLVDIVIATT 366 Query: 357 LEGPRGATAEQLLEHLGNGKSFDS-------VAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 PR A L G F V +A + +A +D +L GS + + Sbjct: 367 PNSPRSMPANVL---AGKMDVFKKPIHVEAEVRKAIEKGLALTGKDDVLLFAGSLYMIGE 423 Query: 410 V 410 V Sbjct: 424 V 424 >UniRef50_B9KIR3 Folylpolyglutamate synthase (FolC) n=5 Tax=Rickettsiales RepID=B9KIR3_ANAMF Length = 455 Score = 181 bits (458), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 138/419 (32%), Positives = 209/419 (49%), Gaps = 32/419 (7%) Query: 23 LHSKTIDLGLERVSLVAARLG-VLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVY 81 L + D L+R++ + RLG K P V VAGTNGKG+T L I +AG + VY Sbjct: 35 LECRVPDFQLDRITKMLERLGNPEKHMPPVVHVAGTNGKGSTIAFLAHIFRSAGIRAHVY 94 Query: 82 SSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLD 141 +SPHLV + ER+ + G+++ ++ AE E+A I T+FE T +A F + + D Sbjct: 95 TSPHLVEFNERIVLSGEQISDAYLDEILAECEAASSGIQTTFFEATTAAAFLAFSKVEAD 154 Query: 142 VVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG 201 + ++EVG+GGRLDATN+V+ ++++TSI+LDHT LG E I EK+GI + +V Sbjct: 155 ITLVEVGMGGRLDATNVVEPIMSIITSISLDHTSSLGTTVELIAGEKSGIIKRGTSCVVA 214 Query: 202 EPEMPS---TIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQP-- 256 E S TI A A L R G+EW+ + FS + E PLP +P Sbjct: 215 PQETESIMRTIEYYAMRDQAFLYRGGIEWSCKKSSGRMLFSTGEASYE-FPLPSLPGDHQ 273 Query: 257 --NAATALAALR----ASGLEVSENAIRDGIASAILPGRFQ---------IVSESPRVIF 301 NA A+AA G ++ I G+ + P R + ++ + R+ Sbjct: 274 VINAGNAIAACSILSGKFGYKIDYEDIVGGLTNTRWPARLERITSGFIPKLLPKGWRLFL 333 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL--EG 359 D AHNP A+ L+ ++ G L ++GM KD L+ LK + + CA Sbjct: 334 DGAHNPAGAQVLSDWIEQSTSGGLYL-IVGMTRGKDSKTFLSCLKKHI-KFLCAVCVKSE 391 Query: 360 PRGATAEQLLE---HLGNGKSFDSVAQA---WDAAMADAKAEDTVLVCGSFHTVAHVME 412 PR AE+L + LG S +S Q+ ++ D+ E T+LVCGS +++ Sbjct: 392 PRAQLAEELAQDAAELGIPSSAESDIQSSIRKILSIGDSGPEPTILVCGSLFLAGDLLK 450 >UniRef50_Q7NLP7 Folylpolyglutamate synthase n=1 Tax=Gloeobacter violaceus RepID=Q7NLP7_GLOVI Length = 413 Score = 181 bits (458), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 143/407 (35%), Positives = 208/407 (51%), Gaps = 22/407 (5%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL++L + LGLER+ + RLG + A VAGTNGKG+ C L IL AGY+ Sbjct: 6 YLDHLQKFGVHLGLERIQALLKRLGEPQVAFQAVHVAGTNGKGSVCAYLSHILQTAGYRT 65 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI--SL---TYFEYGTLSALW 133 G Y+SPHL+ + ER+ + G + + A A A+++++ + SL T FE T +A Sbjct: 66 GRYTSPHLLDWNERIWIDGAFISDGALQACLAKVKASAEHLPKSLGEPTQFEIVTAAAFL 125 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIGREKAGIF 192 F Q+ ++V ++EVGLGGRLDATN+ + A V+T I LDH D LG +I EKAGI Sbjct: 126 HFAQSAVEVAVVEVGLGGRLDATNVFEQPPASVITGIGLDHCDQLGSTLAAIAAEKAGIL 185 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 RS P +V P P + V ++ AL GV + H+ A +A LPL Sbjct: 186 RSGCP-LVCAPLAPEAMQVVTEKALAL----GVVITLAEPAHEVAPGEAQWQGFRYRLPL 240 Query: 253 ---VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 V N+ATALA LR GL + E AIR G+ + + PGR+Q + E R++ D AHN Sbjct: 241 AGGVQLQNSATALATCQVLRERGLPIDETAIRTGLENTVWPGRYQWLGE--RLLLDGAHN 298 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 +A YL + L + ++G+L KD L L D + P+ R E Sbjct: 299 EDSAVYLRRYLDTLHPKESIRWIVGILESKDARAVLKALLRPGDAFVAVPVPDARSHPPE 358 Query: 367 QLLEHLGNGKSFDSVAQA--WDAAMADAKAEDTVLVCGSFHTVAHVM 411 +L + S+A A + A+ + E ++ GS + V+ Sbjct: 359 RLAS-MAQTMGIHSIASASGFSEALQLSDTEQLTVIAGSLYLAGAVL 404 >UniRef50_B9MJT0 FolC bifunctional protein n=2 Tax=Clostridiales RepID=B9MJT0_ANATD Length = 432 Score = 180 bits (457), Expect = 7e-44, Method: Compositional matrix adjust. Identities = 125/415 (30%), Positives = 201/415 (48%), Gaps = 27/415 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L ++ + + LGLE ++ + +G + V VAGTNGKG+TC + +L+ AG+ Sbjct: 7 LDFIHSTYKFGTKLGLENITKLLEFMGNPQKGLKVIHVAGTNGKGSTCAFINQMLIEAGF 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR-------GDISLTYFEYGTL 129 +VG+Y+SP L + ER+++ Q + ++ AS E R G T FE T Sbjct: 67 RVGLYTSPFLESFNERIKLNNQPI-DNQELASITEFVKERIEELIRQGFSHPTEFEVVTA 125 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDA-DVAVVTSIALDHTDWLGPDRESIGREK 188 FK+ +D V+LEVGLGGR DATN+V+ ++ V+TSI DH D LG E I EK Sbjct: 126 IGFEFFKRKNVDFVVLEVGLGGRFDATNVVENPEICVITSIGFDHMDILGSTIEKIAFEK 185 Query: 189 AGIFRSEKPAIVG---EPEMPSTIADVAQEKGALLQRRGVEWNYSV---TDHDWAFSDA- 241 AGI + I+ E+ I+ V +E+ A Q VE NY V T F Sbjct: 186 AGIIKQNTKVILALQRYEEVKEVISKVCKEQNA--QLIEVERNYHVLKSTLEGIVFDCVT 243 Query: 242 -HGTLENLPLPLVPQPNAATALAALRA-----SGLEVSENAIRDGIASAILPGRFQIVSE 295 G +NL + L+ AL + ++ A+ G+ +A GRF+++ + Sbjct: 244 PKGIYKNLEIKLLGTHQVENALNCVYVYECLKEKYDIKTEALIKGLLNARWNGRFEVLID 303 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 +P V+ D AHN + L K + +++AV+G+L DK+ ++ +KSV Sbjct: 304 TPLVVLDGAHNVDGMKVLVENCKIYLNDKKIVAVVGILKDKEYEKMISLIKSVAQRVIFT 363 Query: 356 PLEGPRGATAEQ---LLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 + + A +E+ + H + +A A+ +D V++CGS + V Sbjct: 364 LVPSQKRAFSEKEALEISHKCGVEFVPDFREAIKYALGLCNEDDAVIICGSLYLV 418 >UniRef50_A9KNK7 FolC bifunctional protein n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KNK7_CLOPH Length = 424 Score = 180 bits (457), Expect = 8e-44, Method: Compositional matrix adjust. Identities = 127/385 (32%), Positives = 190/385 (49%), Gaps = 39/385 (10%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 VAGTNGKG+TC+ L SIL AG KVG+++SP L E++++ G E FA++ Sbjct: 44 VAGTNGKGSTCKMLSSILRCAGLKVGLFTSPFLETENEQIQING----EVISNEDFAKVC 99 Query: 114 SARGDISL--------TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VA 164 D + T FE T A F + D+V+LEVGLGG LDATN+++ V+ Sbjct: 100 KKVKDFTTYLMLDEIPTEFELTTAMAFQYFYDTKCDLVVLEVGLGGELDATNVIETPLVS 159 Query: 165 VVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG---EPEMPSTIADVAQEKGALL- 220 V+T+I +DH D+LG + I +KAGI + E +V E E+ I +E+ L Sbjct: 160 VLTNIGIDHVDYLGTTLKEIACKKAGIIK-ENGIVVSYEQEKEVEEVIKLTCEERHNKLV 218 Query: 221 -----QRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV---PQPNAATAL---AALRASG 269 + + + N S FS T NL L L+ + NAA AL A L+ G Sbjct: 219 FAEFSELKLHQENLS----RQKFSYKQNT--NLSLSLIGEHQRKNAAVALEVIAQLQTLG 272 Query: 270 LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAV 329 ++SENAI +G+ PGRF+++ + P VI D HN E + +K + + + Sbjct: 273 YKISENAISEGMNYVTWPGRFEVLCKQPLVILDGGHNVQCVEAFSEVLKQFIPGKKAIVI 332 Query: 330 IGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDS----VAQAW 385 +G+L DKD G + +L + + R +EQL E L S + Sbjct: 333 LGVLADKDYKGMIPYLVPFTKRFIAVTPKNTRALPSEQLAEELSKHHPLVSHNATPVEGI 392 Query: 386 DAAMADAKAEDTVLVCGSFHTVAHV 410 AA+ DA+ +D + V GS + A + Sbjct: 393 MAALRDAREDDIICVIGSLYMAAEI 417 >UniRef50_A6LA17 Folylpolyglutamate synthase n=8 Tax=Bacteroidales RepID=A6LA17_PARD8 Length = 439 Score = 179 bits (455), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 130/383 (33%), Positives = 204/383 (53%), Gaps = 35/383 (9%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 VAGTNGKG+ L +IL +G+KVG+Y+SPHLV + ER+RV G+++ + + F E Sbjct: 51 VAGTNGKGSVSHLLAAILRQSGFKVGLYTSPHLVDFRERIRVNGKKISQD-YVVDFVERH 109 Query: 114 SARGD-ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALD 172 + + + ++FE + A F+ Q++ ++EVGLGGRLD+TNI+ ++++T+I+LD Sbjct: 110 RSFFEPLHPSFFELTSSMAFEYFRDQQVNYAVIEVGLGGRLDSTNIITPILSIITNISLD 169 Query: 173 HTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYS-- 230 HT +LG E I EKAGI + PA++GE E S + DV + K + G + Y+ Sbjct: 170 HTQFLGDTEEKIAAEKAGIIKKGVPALLGEAEKQS-VYDVFKNKA---EEVGAPFYYAQR 225 Query: 231 ---VTDH-------DWAF-SDAHGTLENLPLPLVPQPNAATALAA---LRAS-GLEVSEN 275 V D W F S +G ++ V NA T L+A LR G+++ Sbjct: 226 MDMVKDECRLTVGGKWFFPSVEYGEIQGELGGEVQVRNAVTVLSAIHILRTELGVDIIPE 285 Query: 276 AIRDGIASAI----LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKN-GRVLAVI 330 A+ +G A L GR+Q + P VI D HN E+L +K L + G++ ++ Sbjct: 286 AVHEGFAHVTKLTGLMGRWQTLRSKPTVICDTGHNVGGWEHLAEHLKVLRQYCGQIYMIV 345 Query: 331 GMLHDKDIAGTLAWLKSVVDDWYC---APLEG--PRGATAEQLLEHLGNGKSFDSVAQAW 385 GM++DKDI G L+ + D +Y A +E P A + + H +G D+V A Sbjct: 346 GMVNDKDIDGVLSLMPQ--DAFYFFTQASVERAMPVEDFAVKAMRHGLSGTLCDTVQDAV 403 Query: 386 DAAMADAKAEDTVLVCGSFHTVA 408 + A+ A+ D + + GS VA Sbjct: 404 EKALRRARENDLIFIGGSTFIVA 426 >UniRef50_A8ZTL3 FolC bifunctional protein n=1 Tax=Desulfococcus oleovorans Hxd3 RepID=A8ZTL3_DESOH Length = 434 Score = 179 bits (454), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 132/382 (34%), Positives = 195/382 (51%), Gaps = 24/382 (6%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 +AGTNGKG+ TL +IL AAGY+ G+Y+SPHLV + ER+++ + + +A + + Sbjct: 48 IAGTNGKGSIATTLATILHAAGYRTGLYTSPHLVTFNERIQINNRPVSNAAVVRACKAVR 107 Query: 114 SARGD-ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALD 172 GD T+FEY T A +LF + +D+ ++E G+GGR DATNI+ ++V+++I+++ Sbjct: 108 GLSGDGREPTFFEYTTAMAFYLFAELGVDIAVIETGMGGRFDATNIITPCLSVISNISVE 167 Query: 173 HTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMP--STIADVAQEKGALLQRRGVEWNYS 230 H +LG I EKAGI + P + G + P I VA+++ A L R G E + Sbjct: 168 HRMYLGNTLGEIAGEKAGIIKPGVPVVTGARQKPVLDVIKKVAKKQAAPLYRLGGE--FR 225 Query: 231 VTDH-DWAFSDAHGT------LENLPLPLVPQPNAATALAA---LRASGLEVSENAIRDG 280 V H D FS HG L + NAA ALA L ASG +SE +R G Sbjct: 226 VRRHGDGTFS-YHGISHRWDRLRTVLAGGFQMDNAALALAGCELLMASGKPLSEATVRKG 284 Query: 281 IASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAG 340 +AS P R +IVS+SP ++ D AHN AA+ L + ++ V G+L DK Sbjct: 285 LASTRWPARLEIVSDSPTILIDGAHNLQAAKNLAAFLSEQMAGRKITLVAGILDDKPYRA 344 Query: 341 TLAWLKSVVDDWYCAPLEGPRGATAEQLLE----HLGNGKS--FDSVAQAWDAAMADA-K 393 L L + D + R A A ++LE +LG ++ D V +A A+A K Sbjct: 345 MLRALVPLCDRVILTRAQIGR-AIAPEILEREARNLGATRTHVVDRVDKALAFALAHTPK 403 Query: 394 AEDTVLVCGSFHTVAHVMEVID 415 V V GS + I Sbjct: 404 KSGAVCVAGSLYVAGEARHAIK 425 >UniRef50_C9M7C2 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Synergistaceae RepID=C9M7C2_9BACT Length = 439 Score = 179 bits (453), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 143/400 (35%), Positives = 203/400 (50%), Gaps = 24/400 (6%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GLERVS++ LG + P + +AGTNGKG+T LESI AAGYK +Y+SPHL+ Sbjct: 27 GLERVSVLLEALGTPQAFPAIH-LAGTNGKGSTAAFLESIYRAAGYKTALYTSPHLIHLG 85 Query: 91 ERVRVQGQEL-PESAHTASFAEIESARGDISL-----TYFEYGTLSALWLFKQAQLDVVI 144 ER+ V G L PE AS ++ G L TYFE T +A L + A+ DV I Sbjct: 86 ERLLVNGYPLPPELWAEASQKVAQTILGHPWLSQHRPTYFETLTAAAYLLVRDAKPDVAI 145 Query: 145 LEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE- 202 +E G+GGRLDATNI+ D +AV+T I DH +LG +I EK GI +PAI + Sbjct: 146 IETGMGGRLDATNILPDCRLAVITPIDWDHMAFLGNTLSAIASEKFGIIVPGRPAIFSDN 205 Query: 203 -----PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL-VPQP 256 PE + A + + R + S+ +++ + GT L QP Sbjct: 206 HPELAPEFRACCAAKNSPAYTMDECRIFDAETSLDGCEFSLTTPCGTNRWFSRLLGTYQP 265 Query: 257 -NAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYL 313 NA+ AL A + V+E A R+G+ + PGR ++VS P VI D AHNPH + L Sbjct: 266 ENASLALRATEILQKDFPVTEEARREGLRTVRWPGRLEVVSRDPDVILDGAHNPHGMKAL 325 Query: 314 TGRMKALPKNGRVLAVI-GMLHDKDIAGTLAWLKSVVD-DWYCAPLEGPRGATAEQLLEH 371 T + AL R+L V+ + DKD AG +++ S + C + + Q+L Sbjct: 326 TDSLLALYGKDRLLTVVFTAMADKDYAGEFSYMSSRLKIRLICTRVPHNTRCESAQVLAQ 385 Query: 372 LGNGKSFDSVAQAWD---AAMADAKA-EDTVLVCGSFHTV 407 G F V A + AA+ A+ D V++CGS + + Sbjct: 386 KATGYPFIDVPLAVEDPVAALEKARGFSDPVILCGSLYFI 425 >UniRef50_C7H9L3 Tetrahydrofolate synthase n=2 Tax=Faecalibacterium prausnitzii RepID=C7H9L3_9FIRM Length = 423 Score = 178 bits (452), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 122/368 (33%), Positives = 190/368 (51%), Gaps = 13/368 (3%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L+Y+ + GL R + LG VAGTNGKG+T L S L AAGY Sbjct: 7 LNYIHAVQWAGHKPGLTRTRTLLTALGDPHKQLRFIHVAGTNGKGSTAAMLASCLQAAGY 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWL-- 134 +VG+Y+SP + R+ ER++V GQ++P+ A ++ A ++ E+ ++AL + Sbjct: 67 RVGLYTSPFINRFNERIQVNGQQIPDEALVRLVERVKPAADAMTDIPTEFEIITALGMLW 126 Query: 135 FKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F + + D+V+LEVGLGG LD+TN++D + AV+T++ +DH LGP I KAGI + Sbjct: 127 FAETKCDIVVLEVGLGGTLDSTNVIDPPECAVITALGMDHVKELGPTLADIASAKAGIIK 186 Query: 194 SEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDW-AFSDAHGTLENLPL 250 P + G PE + IA A E+ A L + ++ D D A + L + L Sbjct: 187 PGSPVVSYGGVPEADAVIARTAAERHAPLTVVDLS-RLTIEDGDLDAVTFDFDGLNGIRL 245 Query: 251 PLVP--QP-NAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 PL+ QP NAATA+ A LR+ G + ++AIR G+ PGRF+++ SP + D + Sbjct: 246 PLIGSYQPRNAATAITALRVLRSRGWNIPDSAIRAGLEQVRWPGRFELLRHSPAFLLDGS 305 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HN H ++ + + ++ ++ DKD+ LA L + + PR Sbjct: 306 HNAHGMRATVQSLRDRFPGQKFVFLLSIMADKDVDEMLALLLPLAGQFVTVAAHTPRAMP 365 Query: 365 AEQLLEHL 372 AE L E + Sbjct: 366 AETLAEQI 373 >UniRef50_C0QUQ6 Folylpolyglutamate synthetase n=2 Tax=Aquificales RepID=C0QUQ6_PERMH Length = 406 Score = 178 bits (452), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 113/390 (28%), Positives = 188/390 (48%), Gaps = 9/390 (2%) Query: 32 LERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTE 91 LER+ +G + ++GTNGKG+T LES+L G K G+++SPH++ E Sbjct: 18 LERIKKALEEIGEPQKEFPSILISGTNGKGSTAVYLESLLRYHGLKTGLFTSPHIMEENE 77 Query: 92 RVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGG 151 R +V + + EIE LTYFE + A F +D+ +LEVGLGG Sbjct: 78 RWQVNRKSIEVDKLDRYIKEIEDLIKRYDLTYFEASAVIAFRYFLDENVDIAVLEVGLGG 137 Query: 152 RLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIAD 211 R DATN+V +++V+T+++LDHTD LG I REK GI R ++P ++G +M I+ Sbjct: 138 RWDATNVVYPEISVITNVSLDHTDLLGNSLMEIAREKLGITRKDRPVVIGTDQM-EIISQ 196 Query: 212 VAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQ---PNAATALAAL--- 265 + + + + Y + D + + ++ ++ NAATAL A Sbjct: 197 AVMKGIKEIYHYPIGFTYQIKDRSMDYIFKGKEIRDIRTSILGDRQLSNAATALTAFLLY 256 Query: 266 -RASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNG 324 G++V + ++ I+ + +PGR QI+ E P VI D AHN A +K L Sbjct: 257 SERKGIKVDDEKVKKAISGSFIPGRMQILKEEPPVIVDGAHNLDAVSKTVEEVKRLYPGR 316 Query: 325 RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQA 384 +++ V + DKD + ++S D L R T ++ + + + A Sbjct: 317 KIITVFSCMKDKDYKSIIHIIRSSSDRVIATKLPFSRSITEDE-ISQFKDIDFIPDIDGA 375 Query: 385 WDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 A+ +A ++ VL+ GS + +++ I Sbjct: 376 LKKAIEEADSKSVVLITGSLYLAGEILKKI 405 >UniRef50_Q31PP5 FolC bifunctional protein n=2 Tax=Synechococcus elongatus RepID=Q31PP5_SYNE7 Length = 412 Score = 178 bits (451), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 136/405 (33%), Positives = 209/405 (51%), Gaps = 16/405 (3%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 L + + +DLGL+R V RLG + + +AGTNGKG+TC +++ L A GY+VG Sbjct: 10 LGSFAQRGVDLGLDRSLTVLERLGNPQNQIPIVHIAGTNGKGSTCAFVDTALRANGYRVG 69 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWL-FKQA 138 Y+SPHL+ + ER+++ GQ++ + + +A I LT FE T +A+WL + Sbjct: 70 RYTSPHLISWCERLQLNGQQVSSDRLLEAVQTVLAAADGIDLTPFELLT-AAVWLVLADS 128 Query: 139 QLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKP 197 LD+V++E GLGGRLDATN+V V +TSI DH LGP +I EKAGI +S P Sbjct: 129 DLDIVVIETGLGGRLDATNVVAQPLVTAITSIGHDHQAVLGPTLGAIAAEKAGIIKSRCP 188 Query: 198 AIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG-TLENLPLPLVP 254 +VG PE + I + A++ AL+ +E + W + G T ++ + V Sbjct: 189 VVVGPLLPEARTVIRNRAEQLQALM--IAIEPATVIESGLW---QSQGLTYQSGLIGDVQ 243 Query: 255 QPNAATALAALR---ASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDVAHNPHAA 310 + N+A A+A LR G + + AI G+A PGR Q + + R++ D AHNP AA Sbjct: 244 RINSAIAIAILRQLQQQGWGLQDAAIAQGLADTDWPGRLQWLDYQGRRLLIDGAHNPEAA 303 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 L + L N + +IGML KD LA L D P+ ++E+L Sbjct: 304 IALRQAVDQLLPNQSITWLIGMLRAKDAQAVLATLLRSGDRCIAIPVPDHDCWSSEELQT 363 Query: 371 HLGNGKSFDSVAQAWDAAMADAKA-EDTVLVCGSFHTVAHVMEVI 414 + S A W +A A+ + ++ CGS + + ++ + Sbjct: 364 WAAAQGAIASTAADWAEGLAIAQTYPEAIVFCGSLYLLGDFLQKV 408 >UniRef50_B0S2B5 Folylpolyglutamate synthase n=2 Tax=Finegoldia magna RepID=B0S2B5_FINM2 Length = 415 Score = 177 bits (450), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 117/411 (28%), Positives = 207/411 (50%), Gaps = 23/411 (5%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL+ + LGL+R+ LG + + + VAGTNGKG+T + L GYK Sbjct: 9 YLDKIGRDGYKLGLDRMQKTLKILGNPEKSFKIIHVAGTNGKGSTSTFIYQTLKEHGYKT 68 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA--RGDISLTYFEYGTLSALWLFK 136 G+++SPH++ + +R+++ +E+ E F I+ + DI ++ FE+ TL A++ F Sbjct: 69 GLFTSPHIINFYDRIKID-KEISEEDFMRIFEIIKDTIEKNDIKVSTFEFITLCAIYYFA 127 Query: 137 QAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 + + + V+LEVG+GGRLDATN D ++V+T I LDH ++LG E I EKA I + Sbjct: 128 EQKCEYVVLEVGMGGRLDATNATDETLLSVITKIGLDHQEYLGNTLEEIAYEKACIMKQN 187 Query: 196 KPAIVGEPE--MPSTIADVAQEKGALL------QRRGVEWNYSVTDHDWAFSDAHGTLEN 247 +V + + + +VA+E+ L + + +E N + DW + H +E Sbjct: 188 GRCVVYDQQESVLDVFREVAEERNNKLYICDFDEAKNIEINATHNSFDW--KNLH--IET 243 Query: 248 LPLPLVPQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 + NA AL A+ L++S+ I +G +A +P RF ++ +P VI+D H Sbjct: 244 RLVGRYQLFNAQLALTAIDVLRDELDLSDEDIINGFKNAYIPARFDVIRHNPTVIYDGGH 303 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATA 365 N + L ++++ + +++ V G+L DKD + + + + PR A Sbjct: 304 NADGVKALKSSIESVFGDKKIVFVYGVLKDKDYNDEIKLIHENAKAFVTFTPDSPRALKA 363 Query: 366 EQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 E L + + N + +V A D A+ K +D +++ G+ ++ E Sbjct: 364 EDLKKQIEVYSDNVVAKSNVNDAVDYAIEHFK-DDVIIIFGTLYSAEQAYE 413 >UniRef50_Q5V5Y3 Dihydropteroate synthase n=1 Tax=Haloarcula marismortui RepID=Q5V5Y3_HALMA Length = 799 Score = 177 bits (450), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 141/415 (33%), Positives = 204/415 (49%), Gaps = 35/415 (8%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL++L + LG + + + + LG + +AG+NGKG+T R ES+L AAG V Sbjct: 9 YLQSLQRRRPKLGTDTTARMLSHLGDPDGSFDSVQIAGSNGKGSTARMTESVLRAAGLDV 68 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-----ARGDISLTYFEYGTLSALW 133 G+++SP L + E++ V G +P++ T +IE A D T+FE T AL+ Sbjct: 69 GLFTSPGLNGFREQITVNGGRVPKARVTEFVEQIEPCINQLAAEDDKPTHFEVLTALALY 128 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F +DV +LEVG+GGR DAT+ VD + VTSI+L+HTD LG E I R+K + Sbjct: 129 HFDVEDVDVAVLEVGIGGRYDATSAVDPVASAVTSISLEHTDLLGDTIEEIARDKGQVAP 188 Query: 194 SEKPAIVGE--------PEMPSTI------ADV-AQEKGALLQRRGVEWNYSVTDHDWAF 238 S+ P + G E+ TI ADV A E G R VE S+T +WA Sbjct: 189 SDAPLVTGTAGAALDAIQEITDTITVGSEAADVTATENG---MRSAVENRISLTGSNWAL 245 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 NL L Q A A L ++V I +G+ +A LPGRF++ S P Sbjct: 246 E------SNLKLLGQHQAENAGVAATLARQLIDVDTETISEGLRAATLPGRFEVRSTDPM 299 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 V+ D +HNP A E LT + + + V + DK+ +A L +V + P Sbjct: 300 VVLDGSHNPGAMETLTTLIGRYEYDD-LHVVFAAMQDKEYEQMIATLPAVETAFATRPAV 358 Query: 359 GPRGATAEQLLE----HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 R A+ E L + +SV +A + A+A A +D VLV GS + VA Sbjct: 359 D-RAASTESLAAAFEGQAAQIQQVESVPEATERAIATAGEDDFVLVAGSLYAVAE 412 >UniRef50_B2J1B6 FolC bifunctional protein n=25 Tax=Bacteria RepID=B2J1B6_NOSP7 Length = 448 Score = 177 bits (450), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 145/437 (33%), Positives = 214/437 (48%), Gaps = 47/437 (10%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 S ++ + LGL+R+ + A LG V VAGTNGKG+ C L SIL AGY+ Sbjct: 21 SVIQPFQRFGVHLGLDRIINLLANLGNPHHQVPVIHVAGTNGKGSVCAYLSSILTEAGYR 80 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA--RGDISLTYFEYGTLSALWLF 135 G Y+SPHLV +TER+ + Q + + +++ D S T FE T +A F Sbjct: 81 TGRYTSPHLVDWTERICLNEQPISSEELSQLLEKVQGVIRPEDESATQFEVITAAAWLYF 140 Query: 136 KQAQLDVVILEVGLGGRLDATNI-VDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRS 194 Q Q+DV ++EVGLGGRLDATN+ ++ V ++TSI+ +H LGP I REKAGI + Sbjct: 141 AQQQVDVAVVEVGLGGRLDATNVCLEPIVTIITSISREHWQQLGPTVADIAREKAGILKP 200 Query: 195 EKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG-----TLEN-- 247 P +VG ++P +V ++ R +E + A A G TL+N Sbjct: 201 GCPVVVG--QLPLDAEEV-------VRSRALELKCPIFTPQPARQIATGWAEYQTLQNSQ 251 Query: 248 ---LPLPLVPQ---PNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVS-ESP 297 PLPL Q N+A A+AA L+ G +SE AI G+A PGR Q + + Sbjct: 252 LIKYPLPLAGQIQLANSALAIAALEILQEQGWHISEEAIIKGMAKTQWPGRMQWTTWNNH 311 Query: 298 RVIFDVAHNPHAAEYLTGRMKAL----PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 +++ D AHN AA+ L + +L PK + V+GM DKD A A L D + Sbjct: 312 KILLDGAHNTAAAQVLRQYVDSLDAVNPKP--ITWVMGMFSDKDHADIFAALLRPGDRLF 369 Query: 354 CAPL--EGPRGAT----------AEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVC 401 P+ E G T A +L L + + + A + A++ +D +++C Sbjct: 370 LVPIPVESWTGRTSADLDSLANLAYRLCPQLSDRQIHPDLFTALEVAISTTSTDDLIVLC 429 Query: 402 GSFHTVAHVMEVIDARR 418 GS + V + + R Sbjct: 430 GSLYLVGDFLATTNIIR 446 >UniRef50_D1AM93 FolC bifunctional protein n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AM93_SEBTE Length = 413 Score = 177 bits (449), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 114/395 (28%), Positives = 195/395 (49%), Gaps = 16/395 (4%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 L + V +LG + + +AGTNGKG+ LES+L+ AGY VG ++SPH++++ Sbjct: 20 NLNNIKFVLKKLGNPEKNLKIIHIAGTNGKGSAASMLESVLITAGYNVGKFTSPHIIKFN 79 Query: 91 ERVRVQGQELPESAHTASFAEIE--SARGDISLTYFEYGTLSALWLFKQAQLDVVILEVG 148 ER+ +E+P+ F IE + + +I L +FE T+ F + + D I+E G Sbjct: 80 ERIVYNKKEIPDEEIAGFFDIIEKITEKYNIYLNFFEVTTIIMFCYFNKLKPDYTIIECG 139 Query: 149 LGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV--GEPEMP 206 LGGRLDATN ++ ++V+T+I+ DHT LG + I EKAGI + I E+ Sbjct: 140 LGGRLDATNTGNSYLSVITNISFDHTAVLGNTLKEIAFEKAGIVHDGQICIFAGNHSELT 199 Query: 207 STIADVAQEKGALLQR-RGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAAL 265 + + ++ + + ++ + T S + E +PL + Q L Sbjct: 200 EAVKNKTDNFVDIMTKYKNIDISLDKTTLHTKISLNNSIFE-IPLYGIFQ-GWNFLLVYE 257 Query: 266 RASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGR 325 A L++ ++ I GI+ PGRF+I S+ P +I D AHN + + L + +L Sbjct: 258 TAKILKIEDSIIAKGISDVKWPGRFEIYSKDPLIILDAAHNTDSVKVLRDNILSLYPKSE 317 Query: 326 VLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQLLEHLGNGKSFDSVAQA 384 +I +L DK+I + + D+ +C L E RG T+E+L + S+ Sbjct: 318 TAVIISVLKDKNINEIFSLAEEFTDNIFCTSLSESHRGFTSEELKNVIKRNDP--SIEYY 375 Query: 385 WDAAM------ADAKAEDTVLVCGSFHTVAHVMEV 413 +D + A + + ++VCGSF+ ++ E+ Sbjct: 376 FDDDLEKITRKALSLNKKVLIVCGSFYLISKFKEL 410 >UniRef50_Q3B220 Folylpolyglutamate synthetase n=8 Tax=Chlorobiaceae RepID=Q3B220_PELLD Length = 443 Score = 177 bits (449), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 144/436 (33%), Positives = 214/436 (49%), Gaps = 41/436 (9%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGV-LKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 L +L LH I GLERV ++ G + V VAGTNGKGT + S+ AAG Sbjct: 17 LDFLFPLHRFGIKPGLERVRMLLQAAGSPERSLGMVVHVAGTNGKGTAASAMASMFTAAG 76 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 K +Y+SPHLV +TER+R+ G+ +PE A ++ A + T+FE T A F Sbjct: 77 KKTALYTSPHLVDFTERIRIDGRRIPEDAAARYATLLKPAALEHQSTFFEVTTAIAFAWF 136 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI---- 191 ++V +LE G+GGRLDATN+V++D AV+T I LDHT+WLG +I EKA I Sbjct: 137 ADCGVEVSVLETGMGGRLDATNVVESDYAVLTRIGLDHTEWLGSTISAIAGEKAAIIKPS 196 Query: 192 ---FRSEKP-AIVGEPEMPSTIADVAQEKGALLQRRGVEWNY-------SVTDHDWAFSD 240 F S P A G+ E + D AQ GA LQ G ++++ + D + Sbjct: 197 SRVFTSINPDADPGQSEAFGPVRDAAQGCGAPLQVVGRDFSFGGVVAEPGLLQLDVVTAS 256 Query: 241 AHGTLENLPLPLVP---QPNAATALAALRASGLEVSENAIRDG---IASAILPGRFQIVS 294 H + L +P+ P ATA+A +G V A+R+G +AS GR +++ Sbjct: 257 CH--YKGLRVPVTGAFHAPGIATAVAVAEDAG--VGPEAVREGLDALASTGYRGRLELLG 312 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALP------KNGRVLAVIGMLHDKDIAGTLAWLKSV 348 P DV+HN A+ + + AL ++ RVL G++ DKD + L + Sbjct: 313 HRPDTFLDVSHN---ADGMRATVDALMPFLSRYRDARVL--FGLVSDKDSESMIRELMRL 367 Query: 349 VDDWYCAPLEGPRGATAEQLLE---HLG-NGKSFDSVAQAWDAAMADAKAEDTVLVCGSF 404 + L RG +E+L E LG +F S +A +A + +L+ GSF Sbjct: 368 RCRFATTGLPSERGVASEELAEICRGLGAEAVAFSSPPEALQFLREEASPDSLILITGSF 427 Query: 405 HTVAHVMEVIDARRSG 420 + ++E A ++G Sbjct: 428 YLAGALLEKGTAGKAG 443 >UniRef50_D2RP25 FolC bifunctional protein n=2 Tax=Acidaminococcus RepID=D2RP25_ACIFE Length = 426 Score = 177 bits (449), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 131/416 (31%), Positives = 198/416 (47%), Gaps = 19/416 (4%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 ++Y+E+L I LG+ER+ + A L + V GTNGKG+ L ++L AG Sbjct: 7 VTYVESLGKFGIHLGMERIQGLTALLDHPERKIRTIHVTGTNGKGSVTTFLANMLQQAGK 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEYGTLS 130 KVG Y+SPH VRY ER+ + G+E+ A ++A G T FE+ T Sbjct: 67 KVGSYTSPHFVRYNERICLNGEEISNEDFAAVTERTKAALDRFLAEGGEQPTQFEFITAM 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A F + Q+D ++EVG+GG D+TNI+ +V+V+T++ L+HTD LG E+I +KAG Sbjct: 127 AFLYFAEKQVDYAVIEVGMGGLWDSTNIITPEVSVITNVTLEHTDRLGKTIEAIAAQKAG 186 Query: 191 IFRSEKPAIV-GEPEMPSTIADVAQEKGALLQRRG-----VEWNYSVTDHDWAFSDAHGT 244 I + P + E + I A+ A L G E S+ + + Sbjct: 187 IIKPGVPVVTEAEGKALEVIRGTAEASHAPLYVYGDDFSTEELTSSMDAQTFLYRMGEKE 246 Query: 245 LE-NLPLP----LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 +E + LP ++ A A LR + E A+ G+ +A PGR + + +P + Sbjct: 247 MEVTIHLPGEHQILNGAAALAAAEILREKDGSIDEAAMLRGMDAARWPGRLERIHRNPDI 306 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA-PLE 358 I D AHNP L + R + V GM+ DKD++ L D Y E Sbjct: 307 ILDGAHNPSGVTVLRKALDEYYPGARRIYVFGMMADKDVSQVSEILFRPEDTIYTVLAHE 366 Query: 359 GPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 G R E+L L N D +A A+ A+ +A ED V+VCGS + + E+ Sbjct: 367 GDRSEKPEKLARRLHKNAVPMDELAAAYRRAVQEAGPEDVVIVCGSLYLIGTFKEL 422 >UniRef50_A7VV81 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VV81_9CLOT Length = 432 Score = 177 bits (448), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 130/408 (31%), Positives = 200/408 (49%), Gaps = 38/408 (9%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GLER+ + R+G + VAGTNGKG+ C L S+L AGY+ G+++SP++ + Sbjct: 21 GLERIQALLDRMGNPQKQLKFVHVAGTNGKGSACALLSSVLREAGYRTGLFTSPYITDFR 80 Query: 91 ERVRVQGQELPES------AHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVI 144 ER ++ G+E+PE E + RG++ +T FE T A F + + DVV+ Sbjct: 81 ERFQINGEEIPEETLARILGRLMPMVEEMAERGEV-ITEFELITALAFQWFYEEKCDVVV 139 Query: 145 LEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEP 203 LEVGLGGR DATN++D +A V+ SI+LDHT LG E I EK GI + E +V P Sbjct: 140 LEVGLGGRFDATNVIDTPLAAVIMSISLDHTAILGDTVEQIAFEKCGIVK-EGGDVVLYP 198 Query: 204 EMPSTIADVA-----QEKGALL------------QRRGVEWNYSVTDHDWAFSDAHGTLE 246 + + V G L+ G +Y ++ F AH L+ Sbjct: 199 DQEEGVYGVVAHAVQNHNGRLVLPSPSSVREVSSSIEGTVASYRDEEYQLPFLGAH-QLK 257 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 N A AL L+ G +S A++ G+A A +P R +++ SP VI D AHN Sbjct: 258 N-------AAAAFAALELLKEKGYRISREAMQAGVAKAYIPARMEVLGRSPLVILDGAHN 310 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 P AA L ++ + +++ V+GML DKD +L L S+ A + PR A Sbjct: 311 PGAARVLAQALEKYLPHRKIIGVMGMLKDKDSRSSLRSLASLFQALITASPKNPRALPAA 370 Query: 367 QLL----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 +L E+ + + +++A A A + +++CGS + + Sbjct: 371 ELADRAREYCSQVFAEEDLSKAICLARKLAGEDGAIVICGSLYLAGEI 418 >UniRef50_Q0BQJ2 Folylpolyglutamate synthase n=2 Tax=Acetobacteraceae RepID=Q0BQJ2_GRABC Length = 430 Score = 177 bits (448), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 138/418 (33%), Positives = 210/418 (50%), Gaps = 23/418 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLG-VLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 + L LH K IDL L R+ + +LG + P V VAGTNGKG+TC L ++ AAG Sbjct: 10 IERLHGLHPKMIDLSLGRLEALLEKLGHPERSLPPVVHVAGTNGKGSTCAFLRALAEAAG 69 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 +V VY SPHLV++ ER+R+ G+ + E + E+E +T FE T AL LF Sbjct: 70 QRVHVYISPHLVQFNERIRLAGELVSEPVLVEALEEVERVNAGAPITVFEVITAVALLLF 129 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 + D+ ++EVGLGGR DATN+V V+ + SI++DH ++LG D I EKAGI +S Sbjct: 130 SRVPADLCVVEVGLGGRFDATNVVTPVVSAIASISIDHREYLGDDIRGIAAEKAGILKSG 189 Query: 196 KPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV 253 P + G P++ + A ++G L R +W+ + +SD G + +LPLP + Sbjct: 190 APGVTGLQLPDVLEVLDREAAKQGVSLLARDRDWHIARRGDGLRYSDPDGVV-DLPLPAL 248 Query: 254 PQP----NAATALAALRASGLEVSENAIR-DGIASAILPGRFQ-----IVSESP---RVI 300 P NA A+AA+RA+ + R +G+A A P R Q + + P + Sbjct: 249 PGEHQLDNAGIAVAAMRAAAKTALPLSWRAEGLARAEWPARMQRLTGLLAKDLPDGWELW 308 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 D HNP A L G ++ K+ ++GM KD LA + D + G Sbjct: 309 LDGGHNPGAGVMLAGHLRGW-KDRPAHVIVGMKQAKDAGQFLASVLPEADTVWAIAEPGQ 367 Query: 361 RGATAEQLLEHLGNGKSF--DSVAQAWDAAMADAKAEDT---VLVCGSFHTVAHVMEV 413 A + + GK+ +V QA A + A+A +L+CGS + ++++ Sbjct: 368 YLALPVEAIVSASGGKAIPGPTVRQAMAAILKQAEAGSIPGRILICGSLYLAGEILKL 425 >UniRef50_A3VQ98 FolC bifunctional protein n=1 Tax=Parvularcula bermudensis HTCC2503 RepID=A3VQ98_9PROT Length = 443 Score = 176 bits (447), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 147/419 (35%), Positives = 204/419 (48%), Gaps = 38/419 (9%) Query: 28 IDLGLERVSLVAARLGVLKP---APFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSP 84 I LGL+R+ ARLG P P V VAGTNGKG+TC L SIL AAG KV +++SP Sbjct: 26 ITLGLDRIEEALARLG--NPHHRLPPVLHVAGTNGKGSTCAFLGSILKAAGLKVHIFTSP 83 Query: 85 HLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVI 144 HLVR+ ER+ + G+ + + A+ E+A GD+ L+YFE T SA F + DVVI Sbjct: 84 HLVRFNERITLAGEPISDDLLAATLGRCEAAAGDLPLSYFEAVTASAFLAFAETAGDVVI 143 Query: 145 LEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG-- 201 LE GLGGRLDATN++D A++T IALDH +LG + I EKAGI ++ + G Sbjct: 144 LETGLGGRLDATNVIDHPRAAIITPIALDHQRFLGTELADIAFEKAGILKAGAAFVTGAQ 203 Query: 202 EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQP----N 257 E + A GA G +W++ + D G L +L LP + N Sbjct: 204 RHEALPVLKSRALAIGAHPHVYGEDWSFRQEAGRLVYEDEDG-LRDLGLPRLAGSHQVEN 262 Query: 258 AATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI-------------FDVA 304 AA A+AAL+A GL + GI +A P R Q ++ P V D Sbjct: 263 AALAVAALKAGGLLPDDQTASYGIETAFWPARLQRLTRGPLVDRAQRHAGEHAELWLDGG 322 Query: 305 HNPHAAEYLTGRMKALPKNG--RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 HNPHAA L + L + V+ ++GM +KD G A + + + + Sbjct: 323 HNPHAARALARALADLDDHTPRPVILIVGMQENKDAEGFFAAFEGLASAVFTVEAKSGTP 382 Query: 363 ATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDT---------VLVCGSFHTVAHVME 412 +L E + +V AA D E+T +L+CGS + HV+E Sbjct: 383 VVKSRLAE-MAQKAGLPAVPVENIAAGIDQAVEETGRSGEGMPRILICGSLYLAGHVLE 440 >UniRef50_B6YQL7 Folylpolyglutamate synthase n=7 Tax=Bacteroidales RepID=B6YQL7_AZOPC Length = 432 Score = 176 bits (447), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 111/383 (28%), Positives = 195/383 (50%), Gaps = 39/383 (10%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 +AGTNGKG+T L S+L + YKVG+Y+SPHL+ + ER+++ G + ++ A+ + Sbjct: 51 IAGTNGKGSTSHLLASVLQESNYKVGLYTSPHLLDFRERIKINGSSINKNFVINFIAKYK 110 Query: 114 SARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDH 173 I ++FE T A F + +DV ++EVGLGG+LD TN++ ++++T+I+ DH Sbjct: 111 FFFESIQPSFFELTTAMAFSYFAEQAIDVAVIEVGLGGKLDCTNLITPVLSIITNISFDH 170 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIVGEPE-------------MPSTIADVAQEKGALL 220 T+ LG I +EKAGI + P I+G+ E +T AQE+ +L Sbjct: 171 TNLLGNTLTQIAKEKAGIIKPNIPVIIGKAEEKVKKVFLDLKRKAQNTKFIFAQEENFIL 230 Query: 221 QRRGV---EWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAA---LRASGLEVSE 274 + + W + ++ ++ G + NA T L A L+ L + Sbjct: 231 SSKLLLSGYWQLNTKEYPNLINELGGYAQ--------IQNAVTTLCAIKILKRDVLNIPP 282 Query: 275 NAIRDGI----ASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVI 330 A+ G A+ + GR+QI+ +P+++ D+ HN EY+ ++++ K ++ + Sbjct: 283 QAVYRGFRYVTANTGIKGRWQILQYAPKILLDIGHNIGGLEYVVQQLES-EKYDKLHIIF 341 Query: 331 GMLHDKDIAGTLAWL-KSVVDDWYCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAW 385 G++ DKDI L L K+ + +Y PR A+ L+ + + G+++ +V A+ Sbjct: 342 GIVSDKDILSILQILPKNAI--YYFTQANIPRALNAQTLMNYAKSFGLRGRNYSTVTHAF 399 Query: 386 DAAMADAKAEDTVLVCGSFHTVA 408 +A A ED + + GS VA Sbjct: 400 ASAKLSATKEDVIFIGGSTFVVA 422 >UniRef50_B0T696 FolC bifunctional protein n=2 Tax=Alphaproteobacteria RepID=B0T696_CAUSK Length = 437 Score = 176 bits (446), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 144/423 (34%), Positives = 211/423 (49%), Gaps = 34/423 (8%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLG-VLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 L+ L+ LH K IDL L+R+ + LG K P V VAGTNGKG+T L ++ AAG Sbjct: 12 LARLQALHPKLIDLSLDRMRRLCTALGEPQKRLPPVIHVAGTNGKGSTVAYLRAMAEAAG 71 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAE-IESARGDISLTYFEYGTLSALWL 134 V V++SPHLVR+ ER+R+ G L AH A E +E+A + +T+FE T +AL Sbjct: 72 LTVHVFTSPHLVRFAERIRLAGT-LITDAHLADVLERVEAANAGLPITFFEITTAAALQA 130 Query: 135 FKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRS 194 F + D+ ++EVGLGG LDATN+V V+V+ I +DH ++LG +I +EKAGI + Sbjct: 131 FSEVPADLCLVEVGLGGVLDATNVVSPVVSVIAPIDIDHREFLGDTLAAIAQEKAGIIKP 190 Query: 195 EKPAIVGEP-----EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 P + + AD+++ L+ R WN + L +LP Sbjct: 191 NTPVVSARQAEEAERVVEREADLSEAPLTLMGRDFDAWN----ERGRLLVQLQDRLLDLP 246 Query: 250 LPLVPQ----PNAATALAA-LRASGLEVSENAIRDGIASAILPGRFQIVSESP------- 297 P +P NA A+AA L + + E A+ GIA+ P RFQ ++ P Sbjct: 247 APSLPGEHQFANAGLAVAAILTLNDPRIDEAAMARGIAATTWPARFQRLTAGPLAERAKA 306 Query: 298 ---RVIFDVAHNPHAAEYLTGRMKAL-PKNGRVLAVI-GMLHDKDIAGTLAWLKSVVDDW 352 + D HNPHA + + L ++GR +A+I G+L +KD G A S+ Sbjct: 307 ADADLWLDGGHNPHAGLAVARALGDLAARDGRPVALIAGLLANKDATGFFAPFASLKARL 366 Query: 353 YCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 + EG A+A Q + DSV +A D A+A + VL+CGS + Sbjct: 367 FSVTFEGHAAASAAQTAAAAELAGIRAHACDSVREALDKALA-IEPTPHVLICGSLYLAG 425 Query: 409 HVM 411 V+ Sbjct: 426 EVL 428 >UniRef50_B1CAR2 Putative uncharacterized protein n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1CAR2_9FIRM Length = 433 Score = 176 bits (446), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 118/408 (28%), Positives = 191/408 (46%), Gaps = 30/408 (7%) Query: 30 LGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRY 89 LGL+ + + RLG + V +AGTNGKG+ L +L AGY VG+Y+SP L ++ Sbjct: 20 LGLDNILNLLDRLGNPQKDLKVIHIAGTNGKGSISTMLNGVLTQAGYNVGLYTSPFLEKF 79 Query: 90 TERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEYGTLSALWLFKQAQLDVV 143 ER++ ++P+ E++ + G T FE T AL+ FK+ +D+V Sbjct: 80 NERIKTNNMDIPDEDIAYYLTEVKEKINEMISEGLNHPTEFEIITAMALYYFKEKNVDIV 139 Query: 144 ILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV-- 200 ILEVGLGGRLDATN++D + ++ SI+ DHT++LG + I EK GI + I+ Sbjct: 140 ILEVGLGGRLDATNVIDDPILEIIASISFDHTEYLGNTLKQIAYEKGGIIKENSKVILYP 199 Query: 201 GEPEMPSTIADVAQEKGA---LLQRRGVEWNYSVTDHDWAFSDAHGT--LENLPLPLVPQ 255 E + +++EK + +R +E + D + LE L L+ + Sbjct: 200 SHKEALDELIRISKEKNTSYIIGNKRDIELIKTDIDGSELYYKKENEFGLEKFRLSLLGE 259 Query: 256 P---NAAT---ALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHA 309 N T AL L+ G ++++ I + + GRF+I ++ P +I D HN Sbjct: 260 NQIYNVLTVIKALETLKKDGYKINKCNIEKALTNIHFNGRFEIFNKKPYIILDGGHNKEG 319 Query: 310 AEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLL 369 E +K K+ ++ GML DKDI L L + Y R T++ + Sbjct: 320 IESFVKNIKLYFKDKKITLFFGMLADKDIDSALKKLIPLSKKIYTLTPNNNRAYTSKDMY 379 Query: 370 EHLGNGKSFDSVAQAWD-------AAMADAKAEDTVLVCGSFHTVAHV 410 E + K D+ +A A + D +++ GS + + V Sbjct: 380 EKI---KKVDNHIEATYLDESDEIAGIIDKNSDEIYAFVGSLYLIGEV 424 >UniRef50_C0ZAJ3 Folylpolyglutamate synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0ZAJ3_BREBN Length = 457 Score = 176 bits (445), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 141/420 (33%), Positives = 204/420 (48%), Gaps = 43/420 (10%) Query: 31 GLERVSLVAARLG-VLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRY 89 GLER+ V ++G + PF+ VAGTNGKG+TC L +LM AGY VG ++SP+LV + Sbjct: 28 GLERMQWVLEQVGHPERRIPFIH-VAGTNGKGSTCAFLTQMLMEAGYSVGTFTSPYLVDF 86 Query: 90 TERVRVQGQELPESAHTASFAEI---------ESARGDISLTYFEYGTLSALWLFKQ-AQ 139 ER+R G + E E+ E+ G S T FE TL A+ F + A+ Sbjct: 87 RERIRYNGSMIAEEDLLQLVNEVKVWVQRCEQETEYG--SPTEFEVITLIAILYFSRVAR 144 Query: 140 LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI 199 VV+ E GLGGRLD+TN+V V+V+T+I +DHT LG E I REKAGI + P + Sbjct: 145 PAVVVWETGLGGRLDSTNVVLPLVSVITNIGMDHTQVLGESLEDIAREKAGIIKPGVPVV 204 Query: 200 VGE--PEMPSTIADVAQEKGALLQRRGVEWN-----YSVTDHDWAFSDAHGTLE---NLP 249 GE PE+ + + A++ + L G + + D + + H E L Sbjct: 205 TGEVRPELLAVFEERARQMKSTLYHIGEHFQAEQVEEQLGDQQFGYKSIHRRAEASYRLT 264 Query: 250 LPLVPQ-PNAATALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 + + Q NAA AL + + E I G+ PGR +++S P VI D A Sbjct: 265 MNGIHQTTNAAVALMTIDVLRNYFSFLLEEEEISRGLQQTRWPGRLEVISPRPMVILDGA 324 Query: 305 HNPHAAEYLTGRM-KALPKNGRVLAVIGMLHDK---DIAGTLAWLKSVVDDWYCAPLEGP 360 HN E L + + LP ++ + L DK +A +LA +KS + + + P Sbjct: 325 HNQEGMEALVSSLDRLLPDGVQLHLLFSGLADKPLAKMAESLAPVKSKMKKLHVTTFDFP 384 Query: 361 RGATAEQLLEHLGNG---KSFDSVAQAWDAAMAD-------AKAEDTVLVCGSFHTVAHV 410 R A A L E G + F W A + AKA+D ++VCGS + +A V Sbjct: 385 RAAEANSLQESFLAGGWEQEFLDAVPDWRAFLLSWMREKQLAKADDWLVVCGSLYFIAQV 444 >UniRef50_C6WZI5 Dihydrofolate synthase n=2 Tax=Flavobacteriaceae RepID=C6WZI5_FLAB3 Length = 412 Score = 176 bits (445), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 117/391 (29%), Positives = 190/391 (48%), Gaps = 23/391 (5%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GLE + + G + + GTNGKG+ L S+L AGYK G+Y+SPHL+ +T Sbjct: 31 GLENIIALCEHFGNPQRKIKTIHIGGTNGKGSVSNMLASVLYEAGYKTGLYNSPHLIDFT 90 Query: 91 ERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLG 150 ER++V G+ + +++ +I+ ++FE+ T+ A F Q +D+ I+EVGLG Sbjct: 91 ERIKVNGKTCEKEFVFEFIQKLKDLPAEITPSFFEFTTIMAFEYFHQQNVDIAIIEVGLG 150 Query: 151 GRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPST 208 GRLD+TNI+ ++ +T++ALDH D LG E I EKAGI + I G + + + Sbjct: 151 GRLDSTNIISPMISAITNVALDHQDILGETIEEIAFEKAGIIKDGVTVISGAEDETVRNI 210 Query: 209 IADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS 268 I AQ+K + G T SD G + + +V + LR S Sbjct: 211 IRSTAQQKNSRFVDAG-------TIQSELKSDLKGDYQQKNIKVV-----VALVDQLRES 258 Query: 269 GLEVSENAIRDGI----ASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNG 324 GL V+ + G+ + GR+ S P +I D AHN + + +++++PK+ Sbjct: 259 GLNVTAKNVERGLLKVHQNTGFIGRWFEFSSEPLIICDTAHNQAGLQAVFAQLESIPKHK 318 Query: 325 RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL--EGPRGATAEQLLEHLG-NGKSFDSV 381 + ++G ++DK I L L ++ P G E LL++ N K FD V Sbjct: 319 HI--ILGFVNDKKIDDVLGILPRNSTYYFAKPKVNRGRHPLDYEDLLKNSKINYKIFDEV 376 Query: 382 AQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A+ +A + K + + + GS V +E Sbjct: 377 QLAYVSAKQNIKNNEMIFIGGSNFVVGEFLE 407 >UniRef50_B2V618 FolC bifunctional protein n=3 Tax=Sulfurihydrogenibium RepID=B2V618_SULSY Length = 413 Score = 175 bits (444), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 109/394 (27%), Positives = 190/394 (48%), Gaps = 10/394 (2%) Query: 27 TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 I+ GLER+ L + VAGTNGKG+T LES+L GYK G+++SPHL Sbjct: 14 NIEPGLERIRSALKELNNPEKNFKSILVAGTNGKGSTSAYLESLLRHYGYKTGLFTSPHL 73 Query: 87 VRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILE 146 +R ER ++ +E+ + E++ +LTYFE TL A F ++D+ ++E Sbjct: 74 IRENERWQIDRKEIDDKKLQNYINELKPIIEKYNLTYFEACTLLAFKYFSDKKVDIAVVE 133 Query: 147 VGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMP 206 VGLGGR D+TN+++ + +V+T+++ DH LG I EK GI R +KPA++G + P Sbjct: 134 VGLGGRWDSTNVLEPETSVITNVSFDHMHMLGNTLLDIAYEKTGITRQDKPAVIGRNQ-P 192 Query: 207 STIADVAQEKGALLQRRGVEWNYSVTDHD-WAFSDAHGTLENLPLPLVPQPNAATA---- 261 I + + K + +++ D + + + ENL + ++ + + Sbjct: 193 EIIHWLKERKIKEYYIKDIDYFVKEIDFNKYNYKFKEHIFENLEISMLGKRQIENSSLAL 252 Query: 262 ---LAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMK 318 L L + V EN IR + + GR +I+S++P +I D AHN +K Sbjct: 253 TTFLLFLDKNNQPVVENIIRKALYNTKWKGRMEIISKNPFIIIDGAHNEEGLIKTFQEIK 312 Query: 319 ALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSF 378 + N ++ + + DKD + +K D + + R TAE ++LG Sbjct: 313 EIFPNKKIFTIFSFMKDKDTEKMINIIKQNSDFYIATVMPFSRAMTAED-FKNLGIENVK 371 Query: 379 DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 ++ +A + +L+ GS + + +++ Sbjct: 372 ENHLEAVKELKNSVDKDTIILITGSLYLIGEILK 405 >UniRef50_C3J886 Folylpolyglutamate synthase n=15 Tax=Bacteria RepID=C3J886_9PORP Length = 441 Score = 175 bits (444), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 135/412 (32%), Positives = 202/412 (49%), Gaps = 43/412 (10%) Query: 31 GLERVSLVAARLGV--LKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVR 88 GLERV +A +G L VAGTNGKG+T TL +IL AAGY+ G+++SPHLV Sbjct: 28 GLERVLAMAEAIGSPHLGTGIRYIHVAGTNGKGSTSSTLAAILSAAGYRTGLFTSPHLVD 87 Query: 89 YTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVG 148 + ER+R+ G + E A S ++FE TL AL F ++DV I+EVG Sbjct: 88 FRERIRIDGMPIEECAVVDFVERTRPLIERFSPSFFELTTLMALHHFAAKKVDVAIIEVG 147 Query: 149 LGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPST 208 +GGRLD+TNI+ ++++VT+I+LDHT +LG E I EKAGIF+ PA+VGE ++ Sbjct: 148 MGGRLDSTNIITPELSIVTNISLDHTQFLGSTLEEIAGEKAGIFKPNVPALVGEAS--AS 205 Query: 209 IADVAQEKGALLQ-----------------RRGVEWNYSVTDHDWAFSDAHGTLENLPLP 251 + V + K LL RG W D+ + + G + L Sbjct: 206 LRPVFRAKAELLDAPLYFAEDSDVLQDAEPDRG-GWLLHTRDYGTLWGELGGAAQRL--- 261 Query: 252 LVPQPNAATALAALRA---SGLEVSENAIRDGIASAI----LPGRFQIVSESPRVIFDVA 304 NA T LAAL ++ A+ +G A + L GR+Q V+ P D Sbjct: 262 -----NARTILAALSILARQSFQIPRVAVEEGFAHVVERSHLLGRWQKVASQPDTYCDTG 316 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HN + ++K + + V GM+ DKD L L + ++ P R + Sbjct: 317 HNEAGICLVVEQLKQ-EQYQALHIVFGMVADKDWHSVLRLLPTSAHYYFVQP-TSDRALS 374 Query: 365 AEQLLEH---LG-NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 +E+L + +G G F S+ + AA +A +D + + GS + VA ++ Sbjct: 375 SEELAQEARSIGLEGSVFPSIEEGCLAAQKEALPQDLIYIGGSNYVVAEALK 426 >UniRef50_B3CMD5 Folylpolyglutamate synthase n=2 Tax=Wolbachia endosymbiont of Culex quinquefasciatus RepID=B3CMD5_WOLPP Length = 436 Score = 175 bits (444), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 127/408 (31%), Positives = 201/408 (49%), Gaps = 30/408 (7%) Query: 25 SKTIDLGLERVSLVAARLGV-LKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSS 83 S+ D L+R+ +LG K P + +AGTNGKG+T + I+ AAGYKV Y+S Sbjct: 13 SRPKDFSLDRIKSFLNKLGNPEKKIPPIIHIAGTNGKGSTLSFIRYIMQAAGYKVHTYTS 72 Query: 84 PHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVV 143 PHLV + ER+ V G ++ +S S E A + +T FE T +A F + + D+ Sbjct: 73 PHLVNFNERIVVAGNDIDDSELHNSLEECRIAVAEQPITLFEAATTAAFLAFSRHKADIT 132 Query: 144 ILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG- 201 ++EVGLGGRLDATN++D + ++TSIALDHT++LGP E+I EKAGI + P ++ Sbjct: 133 LVEVGLGGRLDATNVIDNPILTIITSIALDHTEYLGPTVETIAGEKAGIMKPNVPCVIAP 192 Query: 202 -EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLP-------LV 253 E + +T+ A K + L R G EWN ++ F ++E LP ++ Sbjct: 193 QEKSIMNTLEQHAINKKSPLYRGGFEWNCEKQNNRMVFQSTIQSIE-FSLPSLKGDHQII 251 Query: 254 PQPNAATALAALRAS-GLEVSENAIRDGIASAILPGRFQIVSESP---------RVIFDV 303 NA A + L G + E I G+ S P R + + E ++ D Sbjct: 252 NSGNAIAACSILSGKYGFNIGEEDIASGLQSTYWPARLESIKEGNLISLLPKDWQLFLDG 311 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 AHN A L ++ G + + G+ ++++A L LK + ++ A Sbjct: 312 AHNNDGARVLAKWVRDNFAEG-IYMIFGVTRNRNVAEFLEHLKPYIKLLCAVCVKSEPKA 370 Query: 364 TAEQLL----EHLG-NGKSFDSVAQAWDAAMADAKAED--TVLVCGSF 404 T+ L+ ++G N +S+ A + A ++ T+L+CGS Sbjct: 371 TSTDLIREGAHNIGINAIECESIRDAISNHILKASIQNVKTILICGSL 418 >UniRef50_A8F8Q4 FolC bifunctional protein n=1 Tax=Thermotoga lettingae TMO RepID=A8F8Q4_THELT Length = 441 Score = 175 bits (443), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 129/433 (29%), Positives = 215/433 (49%), Gaps = 39/433 (9%) Query: 15 SWLSYLENLH----SKTIDLGLERVSLVAARLG----VLKPAPFVFTVAGTNGKGTTCRT 66 ++L LE L+ S I LGL+R+ + RLG V K A +AGTNGKG+ R Sbjct: 2 TYLKMLEYLYKERPSGKITLGLDRIQKLCERLGNPQNVFKSAH----IAGTNGKGSVTRF 57 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDIS 120 L + + G K Y SPHL + ER+ V + + + +F E++ A G+ S Sbjct: 58 LSWLFIEHGLKTAAYYSPHLTSFKERILVDEKFITDETMLNAFHEVQQAAIELDKEGEQS 117 Query: 121 L-TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGP 179 ++FE+ T A +++ + +EVGLGGR DATN++ +V+V+ ++ DH LG Sbjct: 118 KPSFFEFTTAMAFCVYRDMKTQAASIEVGLGGRFDATNVLTPEVSVIVTVGFDHMHILGN 177 Query: 180 DRESIGREKAGIFRSEKPAIVGEP-EMP-STIADVAQEKGALLQRRGVEWNYS-----VT 232 E I EKAGI + P + GE E+P + I VA K + + G ++ Y ++ Sbjct: 178 TLEKIAFEKAGIIKENIPVVCGETNEIPLNVINQVAHLKNSSVYLLGKDFYYDNEKLFLS 237 Query: 233 DHDWAFSDAHGTLENLPLPLVPQP---NAATALAAL----RASGLEVSENAIRDGIASAI 285 ++ + F L++L + L NA+ AL A + + +++ + IR ++ Sbjct: 238 NNTFDFHSDIIELKDLKISLNGAHQFLNASVALQAFLIFAQRNNIKIDKLRIRSALSKTT 297 Query: 286 LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 +PGRF++V E P+VIFD AHN AA L +K ++ ++ AVIG++ DKD L + Sbjct: 298 MPGRFEVVGEKPKVIFDGAHNLSAALVLRKSIKDYLEDEKIAAVIGIVDDKDKRSILTQI 357 Query: 346 KSVVDDWYCA-PLEGPRGATAE--QLLEHLGNGKSFD-SVAQAWDAAMADAKAEDTVLVC 401 + D P T E Q+ + + +A++ +D +T++V Sbjct: 358 APMFDRIVVTRPFSHRAQNTQETFQITREINANTILEPDPIKAYEILKSDGY--ETIIVT 415 Query: 402 GSFHTVAHVMEVI 414 GS + V ++ + I Sbjct: 416 GSLYLVGYLRDYI 428 >UniRef50_B3QVA8 FolC bifunctional protein n=1 Tax=Chloroherpeton thalassium ATCC 35110 RepID=B3QVA8_CHLT3 Length = 432 Score = 175 bits (443), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 124/406 (30%), Positives = 195/406 (48%), Gaps = 22/406 (5%) Query: 30 LGLERVSLVAARLGVLKPAPFVFT---VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 LGLE + + LG P + T VAGTNGKG+ SI G KVG+YSSPHL Sbjct: 20 LGLENIQALCDALG--NPERNLGTIVHVAGTNGKGSVSAMTASICKEMGKKVGLYSSPHL 77 Query: 87 VRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILE 146 +TER+++ G +P+ +I+ IS T+FE T A F + ++DV ++E Sbjct: 78 ACFTERIKINGMSIPKEKVAEYCTQIKEIVPRISSTFFEVTTALAFKYFAEEKVDVSVIE 137 Query: 147 VGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMP 206 G+GGRLDATN++ + +V+T++ L+HT+WLG +E I EKA I R + ++ Sbjct: 138 TGIGGRLDATNVIPSSYSVITNVELEHTEWLGETKEKIAVEKADIIRPKSSVFTAAKDLD 197 Query: 207 S--TIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH-----GTLENLPLPLVPQPNAA 259 + I A+++ A ++ +Y + + H T L +P A Sbjct: 198 ALEVITRTARDRKAKIRIASALSDYQIISQEIGLLSVHLRTKRRTYHGLKVPFSGSYQAE 257 Query: 260 TA-LAALRASGLEVSENAIRDGIASAILP----GRFQIVSESPRVIFDVAHNPHAAEYLT 314 A LA L A + E IR+G+A+ R + V E P V+ DV+HNP + Sbjct: 258 NAQLAILLAEEMGADELQIRNGLANVHQNTGHRARLERVQEKPVVLLDVSHNPPGMQATV 317 Query: 315 GRMKALPKN-GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG 373 + KN RV V L +KD+A +A LK+ D + + L+ + A ++ + Sbjct: 318 KTISHYRKNYARVAVVFAALQEKDVASMVAALKNGCDKIFVSELKIEKALPATEIHQICE 377 Query: 374 ----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + F + A AA A + VL+ GSF+ V+ ++ Sbjct: 378 AQDVRAEVFPNPMDAIAAAKAFVGEDGLVLITGSFYLAGEVLAFLE 423 >UniRef50_C9RB31 FolC bifunctional protein n=1 Tax=Ammonifex degensii KC4 RepID=C9RB31_AMMDK Length = 426 Score = 175 bits (443), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 140/416 (33%), Positives = 207/416 (49%), Gaps = 27/416 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L+Y++ + + I GLER+ + RLG V GTNGKG+ L SIL AAGY Sbjct: 5 LAYIQQVAAVGIKPGLERIEALLERLGNPHRRLRFLHVGGTNGKGSVTAFLSSILRAAGY 64 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAH----TASFAEIESARGD-ISLTYFEYGTLSA 131 +VG ++SPHL Y ER R+ G+ + E + +E+ R + I LT FE T A Sbjct: 65 RVGTFTSPHLRSYLERFRLNGRPIREREFVWLVNELYPHLEALRQEGIRLTEFEIHTALA 124 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 LF +A+++V ++EVGLGGR DATN+V ++AV+T++A+DHTD+LG D SI REKAGI Sbjct: 125 FLLFARARVEVAVVEVGLGGRWDATNVVLPELAVITNVAVDHTDYLGSDITSIAREKAGI 184 Query: 192 FRSEKPAIVGEP-EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWA-----FSDAHGTL 245 ++ P + G E + +VA+EKGA L +G ++++ +D G Sbjct: 185 IKAGVPVVTGATGEALRVVEEVAREKGAPLYVQGRDFSFREKANDLTGQVIEVEGWWGKT 244 Query: 246 ENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 L L L+ + + A L G ++ + AI+ G+ PGR +IV P + Sbjct: 245 PPLRLNLLGRHQQSNAALAVAAARLLEERGWQIDKGAIKVGLYRTRWPGRLEIVFSQPTL 304 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 I D AHNP L + GR L V+GM DK +K +V + Sbjct: 305 ILDGAHNPAGTAALREALDYYFPRGRRLLVLGMCDDK---AREEMVKIIVPGASLVVVTR 361 Query: 360 PRGATAEQLLEHLGNGKSF-------DSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 P G +E +S + +A A+ A+ ED V+V GS + V Sbjct: 362 PPGPRSEDWRRVADWARSLCPQVYLVEEPQEALGQALRQARPEDLVVVTGSLYLVG 417 >UniRef50_C0QB10 FolC n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QB10_DESAH Length = 480 Score = 174 bits (442), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 128/428 (29%), Positives = 214/428 (50%), Gaps = 27/428 (6%) Query: 4 KRTPQAASPLA--SWLSYLENLHSKT---IDLGLERVSLVAARLGVLKPAPFVFTVAGTN 58 KRT +A+ + S+ LE ++ + I LGLE +S + LG + +AGTN Sbjct: 39 KRTDRASHKMKQISYEECLERMYKRGRFGIKLGLETISEILTNLGSPEKRFKSIHIAGTN 98 Query: 59 GKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA-RG 117 GKG+ + SIL AG+KVG+Y+SPHL+++ ER + G+E+ ++ ++ + A Sbjct: 99 GKGSIASYIASILKEAGFKVGLYTSPHLIKFNERFVINGREVSDNDIVEAYVALNKADTA 158 Query: 118 DISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWL 177 + T+FE T A +LF + ++ I+E G+GGRLDATNI+ ++V+++I+L+HT++L Sbjct: 159 ERKATFFELATAIAFYLFAREGVEWAIIETGMGGRLDATNILLPKLSVISNISLEHTEYL 218 Query: 178 GPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD 235 G E+I EK GI + + P + G + + + +AQ+ A L R +++ S Sbjct: 219 GNTLEAIAMEKGGIIKHKTPVVTGVNQENALAVLTKLAQKNMAPLYRLDNDFHVSQEPDR 278 Query: 236 WAFS------DAHGTLENLPLPLVPQPNAATALAAL-------RASGLEVSENAIRDGIA 282 F+ G LP L N+A A+AA+ + +S+ I+ GI+ Sbjct: 279 TRFTYNGIERTITGVQTRLP-GLHQLDNSAIAIAAVELVFPPQKKQASVLSDEIIQRGIS 337 Query: 283 SAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTL 342 PGR + + ++P V+ D AHN AA L + + R+ V+G+L DKD + L Sbjct: 338 KTQWPGRLETIMQTPFVVIDGAHNLAAAINLARYFEEKFSDKRLTLVLGILDDKDFSSML 397 Query: 343 AWLKSVVDDWYCAPLEGPRGATA---EQLLEHLGNGK--SFDSVAQAWDAAMADAKAEDT 397 D + R EQ L G+ + V A A+A + ++D Sbjct: 398 KQFVPWADRIIFTRADNKRSIDPHLLEQTARTLFTGEITVIEKVGDAVAHAIATSSSQDA 457 Query: 398 VLVCGSFH 405 V + GS + Sbjct: 458 VCIAGSLY 465 >UniRef50_B3ELQ9 FolC bifunctional protein n=2 Tax=Chlorobiaceae RepID=B3ELQ9_CHLPB Length = 436 Score = 174 bits (442), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 141/416 (33%), Positives = 200/416 (48%), Gaps = 19/416 (4%) Query: 17 LSYLENLHSKTIDLGLERV-SLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 +++L LH + GLER+ SL+ A K V +AGTNGKGT + SI +AG Sbjct: 20 INFLFPLHRFGMKPGLERIRSLLNAVGNPQKRLGKVVHIAGTNGKGTVAYAVASIFSSAG 79 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 + G+Y+SPHLV +TER+ V G +PE A ++ D T+FE T A F Sbjct: 80 FTTGLYTSPHLVSFTERICVNGCRIPEPQVAAYCDVLKEEVADRKATFFEVTTAMACMYF 139 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFR-- 193 + Q +V ++E G+GGRLDATN+VD D ++ SI DHT WLG E I EKA I + Sbjct: 140 AEMQAEVSVIETGMGGRLDATNVVDPDYVIIPSIGKDHTAWLGDTVEKIAAEKAAIIKKG 199 Query: 194 SEKPAIVGEPEMPSTIADVAQEKGA---LLQRRGVEWNYSVTDHDWAFS-DAHGT-LENL 248 S V +P I A GA +LQ +S + FS A G L Sbjct: 200 SRVYTAVKDPAALKPIIGRAAAVGATLHVLQDFPEPVVHSAAVGELVFSLKARGADFRKL 259 Query: 249 PLPLVPQPNAAT-ALAALRASGLEVSENAIRDGIASAILPG---RFQIVSESPRVIFDVA 304 + +A+ LA L A + E +IR G+ S G R + +S P ++ DVA Sbjct: 260 KSGVTGDFHASNLELAVLAAHDAGIEERSIRKGLLSMRDFGYRARLERLSGKPDLLLDVA 319 Query: 305 HNPHAAEYLTGRMKALPKNGR-VLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 HNP E + R VL V+G++ DKD+A + LK + L RG Sbjct: 320 HNPDGMEKSVNTLLRFSHAYRNVLVVLGLVRDKDVAEVVRCLKKLTKTVITVNLLSERGL 379 Query: 364 TAEQLLEHLGNGKSFDSV-----AQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 A +L N + F ++ A+A D A +D VLV GSF+ V++++ Sbjct: 380 PASELGGMCRN-EGFHAIVAETAAEALDIVKRTADKDDLVLVTGSFYLAGEVLKLM 434 >UniRef50_B1ZVD5 FolC bifunctional protein n=4 Tax=Verrucomicrobia RepID=B1ZVD5_OPITP Length = 440 Score = 174 bits (441), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 137/431 (31%), Positives = 213/431 (49%), Gaps = 31/431 (7%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P AA+ + YL L + LGL+R+ L+AA LG + A VAGTNGKG+ Sbjct: 15 PDAAAGFEAVAEYLCGLKAGGSKLGLDRMRLLAAELGHPERALRCVHVAGTNGKGSVAAM 74 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL----- 121 LE+IL AAG++VG+++SPHLV ERV+V Q L + E++ I+ Sbjct: 75 LEAILRAAGWRVGLFTSPHLVHVGERVQVNRQPLAPAEIVGYVRELDVLADRIAAREGPG 134 Query: 122 ---TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLG 178 ++FEY T AL F + + D+ ++EVGLGG DATN+VD ++ V+TSI DH +WLG Sbjct: 135 DRPSFFEYMTAMALLQFGRQRCDIAVMEVGLGGEFDATNLVDPEMTVITSIGFDHCEWLG 194 Query: 179 PDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRR--GVEWNYSVTDHDW 236 E I R KAGI + E+P ++G +P V + + ++ R V Y + Sbjct: 195 HTLEEIARAKAGIIKPERPVVIG--RVPPAAETVIRARAEEMEARVISVREVYGENLAVY 252 Query: 237 AFSDAHGTLENLPLPLVPQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQ-IV 293 ++ G + NAATA A R S +SE AI G+ PGR+Q ++ Sbjct: 253 PETNLAGDYQRW--------NAATATLAARELDSRWRISERAIAHGLWHVRWPGRWQRVL 304 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKAL-PKNGRV-LAVIGMLHDKDIAGTLAWLKSVVDD 351 RVI D +HN A L + L + GR + V+G+L + +A + + Sbjct: 305 VGGRRVILDASHNAEGASVLDANLARLRAETGRAPIVVVGVLGAERAQPLMAAICRHAGE 364 Query: 352 WYCAPLEGPRGATAEQLLEHLGNG----KSFDSVAQAWDAA--MADAKAEDTVLVCGSFH 405 + PR ++ E+L + G + +VA+ + A +D++++ GS + Sbjct: 365 VHLVVPNQPRASSYEELAALIPAGFPGRVARTTVAEIFPGGDHCALGGPDDSIVITGSIY 424 Query: 406 TVAHVMEVIDA 416 + V+ I A Sbjct: 425 LLGEVLPRIGA 435 >UniRef50_Q11UV3 Tetrahydrofolylpolyglutamate synthase (Folylpolyglutamate synthetase) n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11UV3_CYTH3 Length = 429 Score = 174 bits (441), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 117/379 (30%), Positives = 196/379 (51%), Gaps = 31/379 (8%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 VAGTNGKG++ L ++L +AGY VG+Y+SPH+ +TER+R+ G +P+ F + Sbjct: 51 VAGTNGKGSSSSILAAVLQSAGYTVGLYTSPHIHDFTERIRINGVPIPKDI-VVDFVQNN 109 Query: 114 SARGD-ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALD 172 +A D ++FE T+ A F + Q+D+ I+E G+GGRLDATNIV +V+++T+++LD Sbjct: 110 TAVFDRFKPSFFEITTILAFVWFAKQQVDIAIIETGMGGRLDATNIVQPEVSLITNVSLD 169 Query: 173 HTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALL--------QRRG 224 HT +LG ++I EKAGI ++ P ++ E+ + V +E+ L + Sbjct: 170 HTQFLGNTIQAIASEKAGIIKAGIPVVIS--ELQQELISVYEEQANALNSPLIKAFEAYT 227 Query: 225 VEWNYSVTDHDWAFSDAHGTLENLPLPLVPQ--------PNAATALAALRASGLEVSENA 276 V+ + ++H H + + L L Q T + L+ G + E++ Sbjct: 228 VDTIITASEHTEISITDHVLKKIIALRLDLQGLYQSKNVVGVLTVIDQLKKDGWAIPEDS 287 Query: 277 IRDGIAS----AILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGM 332 I++G+A A GR+QI+S+ P I D AHN +++ K+ + VIGM Sbjct: 288 IKEGLAHVQQLAGFKGRWQIISQKPLTILDAAHNEAGITLSMQQLQLYHKSIHI--VIGM 345 Query: 333 LHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAA 388 + DKDI L+ L ++C + PR A +L G++ +V A AA Sbjct: 346 VKDKDIEKVLSLLPVQATYYFCQA-DSPRAMPAAELQTAAAVNGLQGQAITNVNDAVRAA 404 Query: 389 MADAKAEDTVLVCGSFHTV 407 +A +D + + GS + + Sbjct: 405 RKNAAPDDVIWIGGSLYVL 423 >UniRef50_Q0AWF7 Putative uncharacterized protein n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AWF7_SYNWW Length = 416 Score = 174 bits (441), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 128/411 (31%), Positives = 197/411 (47%), Gaps = 35/411 (8%) Query: 23 LHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYS 82 + S I GL R+ + +G + +AGTNGKG+T L ++L AGY+VG + Sbjct: 1 MASSGIKPGLSRIEALLREMGHPEKCLKTVHIAGTNGKGSTSFILSAVLSQAGYRVGRFI 60 Query: 83 SPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL--TYFEYGTLSALWLFKQAQL 140 SPH+ Y ER + + E A+++ ++S T FE T AL F+ Q+ Sbjct: 61 SPHIHSYRERFTINDTFIEEEEFLFYMAQVKKHIKNLSQRPTEFEILTAIALEYFRDKQV 120 Query: 141 DVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV 200 D+ I EVG+GG D+TN+++ V+V+T I DHT +LG E I R KAGI + + P ++ Sbjct: 121 DLAIFEVGMGGIYDSTNVIEPVVSVITGIDYDHTQYLGTSLEEIARNKAGIIKKKVPLVM 180 Query: 201 G------------------EPEMPSTIADVAQEKGALLQRRGVEWNYS--VTDHDWAFSD 240 G P PS++A+V +E A L+ + ++ +S V D + S Sbjct: 181 GPVNPPARQVIAARARELDSPLYPSSLAEVTREAQASLEGQLLKLVFSGQVVDKVFLPSP 240 Query: 241 AHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 A LENL + A TAL L+ +G +E ++ +A +PGR +IV +P I Sbjct: 241 ASYQLENLAV-------AFTALQVLKMAGFLWTEGDMKAALAKLRIPGRMEIVRINPPFI 293 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 D AHNP AA L + + + V+G+L DKD L L + EG Sbjct: 294 LDAAHNPQAASVLASSLNDILPGKKKALVLGVLDDKDAQNILKPLGHNTRVLVLSRPEGS 353 Query: 361 RGATAEQLLE---HLGNGKSF---DSVAQAWDAAMADAKAEDTVLVCGSFH 405 R ++L E L G + + +A + K D +L+ GSF+ Sbjct: 354 RSKNWKRLKEDWLSLFPGADLYMEEDIIEAIKVGESLLKLGDYLLITGSFY 404 >UniRef50_B8FVG3 FolC bifunctional protein n=2 Tax=Desulfitobacterium hafniense RepID=B8FVG3_DESHD Length = 459 Score = 174 bits (440), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 131/427 (30%), Positives = 206/427 (48%), Gaps = 26/427 (6%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL +L ++ GL R+ + R+G + V + GTNGKG+T IL AGY+V Sbjct: 34 YLVSLTKFGMNFGLGRIEELLKRMGNPEERLRVVHIGGTNGKGSTTMMTAEILEDAGYRV 93 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFA------EIESARGDISLTYFEYGTLSAL 132 GV++SPHL Y ER+ + G+ +P+ T E +G T FE T AL Sbjct: 94 GVFTSPHLHDYRERITINGEMIPKGEVTRLIQILRPHLEELVQKGVEHPTEFEVNTAMAL 153 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F ++D+V+LEVGLGG +D+TN+V ++V+T++ +DH D+LG E I KAGI Sbjct: 154 MYFADQKVDLVLLEVGLGGAIDSTNVVKPLISVITNVGMDHMDYLGETYEEIAGVKAGII 213 Query: 193 RSEKPAIVG--EPEMPSTIADVAQEKGALLQRRG--VEWNYSVT---DHDWAFSDAHGTL 245 ++ + PE+ + I AQE + L G V W + + ++ + G Sbjct: 214 KAGAITVTAADRPEVLNVIRKKAQEMNSPLWVVGDDVRWEIRWSGELEQEFDLAGLRGAY 273 Query: 246 ENLPLPLVPQP---NAATALAALR----ASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 L L LV + NAATA+ G+ + I +G+ A+ PGR +++S P+ Sbjct: 274 NKLRLRLVGEHQVVNAATAVTVCELLKFEYGMNLERRNIYEGLRKAVWPGRLELLSLKPK 333 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 V+ D AHN A L + + R++ +GML DK+ + L + D+ Sbjct: 334 VLIDGAHNVDGAHALAKALNIFQRQ-RLVLCLGMLGDKEREKVVDILVPLADEVIITKPN 392 Query: 359 GPRGATAEQLLEHLG-NGKSFDSVAQ---AWDAAMADAKAEDTVLVCGSFHTVAHVME-V 413 PR E L E + GK ++ + A + A ED + V GS + +A + + Sbjct: 393 SPRSGNWEYLHELVKEKGKPVLTIEEPRLAVEEAFRRLDKEDMLCVTGSLYMIAEARQAL 452 Query: 414 IDARRSG 420 +D R G Sbjct: 453 LDVLRKG 459 >UniRef50_Q6MAP9 Putative folylpolyglutamate synthase n=1 Tax=Candidatus Protochlamydia amoebophila UWE25 RepID=Q6MAP9_PARUW Length = 410 Score = 174 bits (440), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 132/406 (32%), Positives = 200/406 (49%), Gaps = 41/406 (10%) Query: 22 NLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVY 81 NLH I LGL + L + VAGTNGKG+ + S L AGY+VGVY Sbjct: 14 NLHGG-IKLGLSNCEKLQTILKFPDHSFSSIHVAGTNGKGSVVAKIASALEYAGYRVGVY 72 Query: 82 SSPHLVRYTERVRVQGQELPESAHTASFAEIE--SARGDISLTYFEYGTLSALWLFKQAQ 139 +SPH+ + ER+RV G + E+ +++ +A+ I T+FE T AL F + + Sbjct: 73 TSPHISSFRERIRVNGIMISEADVEKILSQLFNLTAQYSIPATFFELTTFLALVYFSREK 132 Query: 140 LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI 199 +D +LE GLGGRLDATNIV ++++TSI+LDHTD LG E+I +EKAGI +S P I Sbjct: 133 VDFAVLEAGLGGRLDATNIVSPVLSIITSISLDHTDILGDTLEAIAKEKAGIIKSHTPVI 192 Query: 200 VGEPEMPST-IADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNA 258 +G P+ P I +A +K + T++N L L Q N Sbjct: 193 IG-PQTPYLFIEKLAYQKNSFCH----------------------TIKNQFL-LFDQENN 228 Query: 259 ATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGR 316 A A +L + ++ + AI G+ A P RF+I++ S VI DVAHNP L + Sbjct: 229 AIAKKSLEVLSENWDIPQEAIFKGL-EAKQPCRFEIINNS--VILDVAHNPSGLTSLFAK 285 Query: 317 MKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNG- 375 + N + + G+ KD+ G L L ++ RG + + L + L N Sbjct: 286 TQTHFPNQPLRILFGLSKGKDLEGCLKILSRHGSAFHLVEAPNGRGISFDLLKQGLMNTG 345 Query: 376 ------KSFDSVAQAWDAAMADAKAE-DTVLVCGSFHTVAHVMEVI 414 S ++ + A+ A++ +L+CGSF ++ V + + Sbjct: 346 IASTVIYSHINIQEGVKIAIKQAESSGQLLLICGSFFIMSQVRQAL 391 >UniRef50_D2LDB9 FolC bifunctional protein n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LDB9_RHOVA Length = 457 Score = 174 bits (440), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 143/421 (33%), Positives = 212/421 (50%), Gaps = 30/421 (7%) Query: 20 LENLHSKTIDLGLERVSLVAARLG-VLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 L+ LH K+IDL L RV + LG + P V VAGTNGKG+ L+++L A+GY+ Sbjct: 29 LQTLHPKSIDLSLGRVHRLLRALGDPHRSIPPVVHVAGTNGKGSVVAFLKAMLEASGYRA 88 Query: 79 GVYSSPHLVRYTERVRV--QGQELPES-AHTAS-FAEIESARGDISLTYFEYGTLSALWL 134 V++SPHLVR+ ER+++ QG P S +H A A E+A +T+FE T +A Sbjct: 89 HVFTSPHLVRFHERIQLAAQGGARPISESHLADVLARTETANRGEPITFFEITTAAAFLA 148 Query: 135 FKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIGREKAGIFR 193 F + D+V+LE GLGGRLDATN++D +A V+T+I++DH +LG + E+I EKAGI + Sbjct: 149 FAENPADIVLLETGLGGRLDATNVIDEPLATVLTAISIDHCSYLGDNIEAIAGEKAGILK 208 Query: 194 SEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLP 251 +PAIV E IA A A + G W+ + D +L +LPLP Sbjct: 209 RGRPAIVSRQSDEAMHVIAMRAAALEAPVIAAGASWDVFEQQGHLVYQDEE-SLLDLPLP 267 Query: 252 LV----PQPNAATALAALRA-SGLEVSENAIRDGIASAILPGRFQ---------IVSESP 297 + NA TA+A R G VSE AI GI SA+ P R + + E Sbjct: 268 RLFGHHQFENAGTAIATARNLEGFHVSEAAIAKGITSAVWPARLERLGPGRLHALAPEGS 327 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 + D HNP A E + + L + + + ++GML KD G L + + + Sbjct: 328 EIWVDGGHNPAAGEVVARALADLEERVSSPIHLIVGMLSTKDAGGFLRHFQGLPELTATV 387 Query: 356 PLEGPRGATAEQLLEHLGNGKSF-----DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 +EG A L + + S+ +A+ + A AK +++ GS + V Sbjct: 388 DIEGQTSAYKADELAAIARREGLAAEPAGSLEEAFAKSRAAAKGPIRIVIAGSLYLAGQV 447 Query: 411 M 411 + Sbjct: 448 L 448 >UniRef50_B0MYL2 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MYL2_9BACT Length = 430 Score = 174 bits (440), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 125/404 (30%), Positives = 190/404 (47%), Gaps = 23/404 (5%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GLER++ LG + F VAGTNGKG+ L S+L AGY+ G+Y+SPHL + Sbjct: 28 GLERITAFCKHLGNPQRNYFTIHVAGTNGKGSVSHMLASVLQQAGYRTGLYTSPHLRDFR 87 Query: 91 ERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLG 150 ER+ V G+ +P+ + ++ L++FE T A F Q+ ++V ++E GLG Sbjct: 88 ERILVDGEMIPKQKVVNFVDKHYDCMKELGLSFFEMSTALAFDYFDQSDVEVAVIETGLG 147 Query: 151 GRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEP-----EM 205 GRLDATN++ V+V+T+I LDH LG I EKAGI + P ++GE + Sbjct: 148 GRLDATNLIIPIVSVITNIGLDHMALLGDTLPKIAAEKAGIIKKSIPVVIGEKSDEYNHV 207 Query: 206 PSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS---DAHGTLENLPLPLVPQ---PNAA 259 A K + N+S FS + NL L L N Sbjct: 208 FDQAATAMMSKIVYAENDFACINHSTEGDFQKFSIQRHRDNKVFNLELDLTGNYQVHNIL 267 Query: 260 TALAAL----RASGLEVSENAIRDGI----ASAILPGRFQIVSESPRVIFDVAHNPHAAE 311 TA+A + + + L +S A+ +G+ + L GR+Q + + P I D HN H Sbjct: 268 TAIAVIDLLHQETPLTISLRALTEGMRTVASGTALQGRWQKLGDKPLTICDTGHNAHGIR 327 Query: 312 YLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG---PRGATAEQL 368 Y+ ++ A P + V+G ++DKD++ L + P P G AE+ Sbjct: 328 YVAEQLAATPHRD-LYCVLGFVNDKDLSSVLPLFPKEARYIFTQPGNERALPAGKLAEKA 386 Query: 369 LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 + G+ D+V+ A A A ED + + GS VA V+E Sbjct: 387 AAYGLRGEVADTVSGALARAREMASEEDMIFIGGSNFVVAEVLE 430 >UniRef50_D0RRC3 Folylpolyglutamate synthase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RRC3_9RICK Length = 429 Score = 174 bits (440), Expect = 8e-42, Method: Compositional matrix adjust. Identities = 129/434 (29%), Positives = 207/434 (47%), Gaps = 42/434 (9%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGV-LKPAPFVFTVAGTNGKGTTCRTLE 68 + L L+ L L+ I+L L+RV +A +G K V TV GTNGKG T L+ Sbjct: 4 SKKLQFILNKLYELNPDKIELKLDRVLRLANDVGNPHKKLKNVITVTGTNGKGGTAFYLK 63 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 IL A GY V ++ SP L + R + G+ L E E++ A + +T+FEY T Sbjct: 64 EILQAHGYSVALFQSPFLYNFLTRFLINGEPLDEEKFINYVIEVDKANNNQDITFFEYIT 123 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNI--VDADVAVVTSIALDHTDWLGPDRESIGR 186 A F++A D I+E GLGG+ D+TN+ D V+T I++DH D+LG + I Sbjct: 124 CIAFKAFEEANCDFNIMETGLGGKYDSTNVDYQDLKAQVLTPISMDHKDFLGDTLKEITH 183 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGV-------EWNYSVTDHDWAFS 239 K GI + I+ + + + V +E L+R+ + ++N SV ++ + Sbjct: 184 NKCGIIKDNSNVIIAK-QSSEVLGYVDEE----LKRKKIKKYIFSEDFNVSVENNRMIYQ 238 Query: 240 DAHGTLENLPLPLVPQP----NAATALAALRASGLEVSENAIRDGIASAILPGRFQ---- 291 D G ++ L +P + NAA AL AL++ GL++ I +GI + + GR Q Sbjct: 239 DDDGLID-LDMPNMKGSFQIQNAAVALKALKSIGLKLDNKKISEGIKNTKVEGRIQHITK 297 Query: 292 ------IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 I E+ +I D HN A + L ++ + + V ML KD+ L+ Sbjct: 298 GKLLSYIHEETNTLIVDGGHNEQAGKSLAEYLEKIKGKRSIYLVFSMLTSKDLKAYLSSF 357 Query: 346 KSVVDDWYCAPLEGPRGATAEQLLE--HLG-----NGKSFDSVAQAWDAAMADAKAEDTV 398 S+V + C L T + + + LG N + +++AQ A+ D A + Sbjct: 358 SSLVTEIKCFKLRENFYETKDIIAQAKELGIHANPNNSATEAIAQ---LAIQDPNA--II 412 Query: 399 LVCGSFHTVAHVME 412 +VCGS ++ V+E Sbjct: 413 VVCGSLYSAGKVLE 426 >UniRef50_C6XMV8 FolC bifunctional protein n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XMV8_HIRBI Length = 439 Score = 173 bits (439), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 140/415 (33%), Positives = 201/415 (48%), Gaps = 37/415 (8%) Query: 28 IDLGLERVSLVAARLG-VLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 I GL+R+ A LG P +AGTNGKG+ L S+ A+ V V++SPHL Sbjct: 23 IRFGLDRIKQALASLGDPQNKLPPTIHIAGTNGKGSVAAFLRSMAEASDLGVHVFTSPHL 82 Query: 87 VRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILE 146 +R ER+RV G+ + + A+ +E D LTYFE T +A LF Q Q D+ I+E Sbjct: 83 IRVNERIRVAGRLVTDDELIAALERVEDTGCD--LTYFEALTAAAFLLFSQIQADLCIIE 140 Query: 147 VGLGGRLDATNIV-DADVAVVTSIALDHTDWLG-PDRESIGREKAGIFRSEKPAIVG--- 201 G GG LD+TN++ ++TSI DH G D SI R KAGI RS+ P I+ Sbjct: 141 TGAGGELDSTNVMARPSACIITSIGRDHERMFGVSDIPSIARTKAGIMRSDVPVIISQQT 200 Query: 202 EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV---PQPNA 258 E + + + A++KGA + +W S+ D + F D GT+ L L + NA Sbjct: 201 ENDATQALLEAAKDKGANVILAERDWKDSLEDQSFVFEDDSGTVRAPWLGLAGPHQRMNA 260 Query: 259 ATALAALRASGL-EVSENAIRDGIASAILPGRFQIVSESP-------RVIFDVAHNPHAA 310 A AAL GL V++ + G+ A P R Q + P RV+ D AHNP AA Sbjct: 261 GAACAALNVLGLPHVTKATMSVGLREASWPARMQTLKSGPLQKVIGGRVVVDGAHNPAAA 320 Query: 311 EYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL------EGPRG 362 + L +K+ + + + ++ M +KD +A L V + L EG G Sbjct: 321 KVLAQAIKSQLEFDEAKPIILMAMQGNKDAEKIIAELAPYVSQFVMTSLPTDTGQEGSLG 380 Query: 363 ATAEQLLEHLGNGKSFDSVAQAWD------AAMADAKAEDTVLVCGSFHTVAHVM 411 A +L++ +SF AQA A + D KA DTV +CGS + V+ Sbjct: 381 ADPNKLVKI---AQSFKVSAQAIPSLESAIAKLGDIKA-DTVYICGSLYLAGVVL 431 >UniRef50_B1I4S5 FolC bifunctional protein n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I4S5_DESAP Length = 425 Score = 173 bits (439), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 128/340 (37%), Positives = 177/340 (52%), Gaps = 16/340 (4%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L + L + ++ GLERV + A LG + F + GTNGKG+ + +I A G Sbjct: 7 LEAVRGLAATGVNFGLERVRELLAVLGDPQAGLFAAHIGGTNGKGSVAALVSAIARAGGL 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQ----ELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 KVG ++SPHL YTER + GQ E T + + + T FE T+ AL Sbjct: 67 KVGTFTSPHLSSYTERFLIDGQPVTGERLAGLITTHWNLLAPVARQVRPTEFELHTVLAL 126 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 LF++ ++DV +LEVGLGGRLDATN++ VAV+T++ALDH ++LG I REKAGI Sbjct: 127 QLFREERVDVAVLEVGLGGRLDATNVIRPAVAVITNVALDHQEYLGETIAEIAREKAGII 186 Query: 193 RSEKPAIV-GEPEMPSTIADVAQEKGALLQRRG--VEWNYSVTDHDWAFSDAHG---TLE 246 + P + E IA +E A L R G V W + D +G Sbjct: 187 KPGVPLVTAAEGGALDVIAGACRELDAPLVRVGADVRWEPRDDSGEKQGLDIYGRRAVYR 246 Query: 247 NLPLPLV---PQPNAATALAALRASGLE---VSENAIRDGIASAILPGRFQIVSESPRVI 300 L LPL Q NAA A+AA G + AIR+G+A+ PGRF++++ P V+ Sbjct: 247 GLALPLAGRHQQVNAACAVAAAEVLGEHAPSLGPRAIREGLAAVNWPGRFEVLAGQPTVV 306 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAG 340 D AHNP AA L + A ++ V+G+L DKD AG Sbjct: 307 LDAAHNPAAAVVLRDTLVARFPGREIILVLGVLGDKDRAG 346 >UniRef50_A6DMK1 Folylpolyglutamate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DMK1_9BACT Length = 423 Score = 173 bits (439), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 127/366 (34%), Positives = 181/366 (49%), Gaps = 28/366 (7%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL++L I LGLE + + LG + VAGTNGKG+TC + + AG K Sbjct: 13 YLDSLLVFGIKLGLENMIQLNQLLGDPASSLKFVHVAGTNGKGSTCAMIATACKYAGLKT 72 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEYGTLSAL 132 G YSSP LV + ER R+ G + ES + + +I + R + TYFE T +AL Sbjct: 73 GFYSSPFLVNFLERWRINGSPINESIYLDAMQKIIAIEDELVERTGVKPTYFEVLTAAAL 132 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +FK+ + +VVI E G+GGRLDATNI + + ++T+IA+DH +LG E + +EKAGI Sbjct: 133 LIFKEEKCEVVIWETGMGGRLDATNIANPLLTIITNIAMDHGSYLGDTLEEVAKEKAGII 192 Query: 193 RSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE-NLP 249 + + P I GE PE+ A+ A ++ + D D + G E N Sbjct: 193 KDQVPLICGERKPELRKLFAESANNSTQYFIDS--DFTSAQVDDDILY---QGKQEINYK 247 Query: 250 LPLVPQPN------AATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF-D 302 L L+ + A AL L GL S G+ A PGR Q + P I+ D Sbjct: 248 LRLLGEHQVSNSSLAIKALEVLEDQGLLESAQIAARGLQYAHWPGRIQ---KLPNDIYVD 304 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 AHNP A E L+ P N + + GM+ DK+I TL L + + P++ PR Sbjct: 305 GAHNPAAMEKLSS---CFP-NKKFTVICGMMEDKEIIPTLEKLVPICTKFIAVPIKIPRA 360 Query: 363 ATAEQL 368 A+ L Sbjct: 361 IKAQDL 366 >UniRef50_Q97AP2 Folylpolyglutamate synthase n=2 Tax=Thermoplasma volcanium RepID=Q97AP2_THEVO Length = 407 Score = 172 bits (436), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 121/378 (32%), Positives = 192/378 (50%), Gaps = 19/378 (5%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI- 112 + G+NGKG+T + SIL + VGVY+SPHL R+ ER+ V +E+P+ + F E Sbjct: 21 ITGSNGKGSTSAFIYSILRQK-FSVGVYTSPHLERFNERIIVDNEEVPDE-YIDGFIEKY 78 Query: 113 -----ESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVT 167 E ++ + + T+FE T+ A FK ++D +EVGLGGRLDATNI+ +V+V+ Sbjct: 79 RPKFDELSKVNRNPTFFEVTTMMAFQYFKDRKVDYASVEVGLGGRLDATNIIMPEVSVIA 138 Query: 168 SIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALL----- 220 + +H D LG SI EKAGI + +P ++ + PE+ + + +AQ K + L Sbjct: 139 QVGYEHADKLGCSLTSIAYEKAGIIKEGRPIVLQDDKPEVVNEVRRIAQVKHSPLITLDR 198 Query: 221 -QRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRD 279 + + + + + TD D+ ++ + + NAATA+ A+ S ++V + I Sbjct: 199 NKIKNLHVDENGTDFDFDGTNDTYHIHTSLIGDYQALNAATAILAVENSKVQVYKKDIET 258 Query: 280 GIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIA 339 GI+ I PGR +I+ SP VI D AHNP AA + +K + N V G+L DKD Sbjct: 259 GISRTIWPGRLEIIDRSPLVIIDAAHNPPAANKMVRTVKKV-FNREPTIVAGILSDKDAY 317 Query: 340 GTLAWLKSVVDD-WYCAPLEGPRGATAEQLLEHLGN-GKSFDSVAQAWDAAMADAKAEDT 397 + L+ + + P E R L+ GN +S + A K +D Sbjct: 318 SFFSVLRQLSGKIIFTTPEEKERAVDPNILMAQYGNLFRSARVIPDPISAFEHAKKVDDF 377 Query: 398 VLVCGSFHTVAHVMEVID 415 V V GS + + + + D Sbjct: 378 VFVTGSIYLIGVIRGLYD 395 >UniRef50_D1R940 Putative uncharacterized protein n=1 Tax=Parachlamydia acanthamoebae str. Hall's coccus RepID=D1R940_9CHLA Length = 396 Score = 172 bits (436), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 127/365 (34%), Positives = 182/365 (49%), Gaps = 38/365 (10%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 VAGTNGKG+ + + + AAGY+VG Y SPH+ + ER+ + G+ + E+ E+ Sbjct: 39 VAGTNGKGSVTAKIAAGMQAAGYRVGRYVSPHIATFRERMSINGEMISEAEVVEILNELF 98 Query: 114 SA--RGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIAL 171 + R IS T+FE TL A F Q + D+ +LE GLGGRLDATNIV ++V+TSI++ Sbjct: 99 AVADREKISPTFFELTTLLAFCFFAQKKADIAVLETGLGGRLDATNIVHPILSVITSISV 158 Query: 172 DHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMP-STIADVAQEKGALLQRRGVEWNYS 230 DHT+ LG E I +EKAGI +S P ++G P +P S I +A E + L YS Sbjct: 159 DHTEILGHTLEEIAKEKAGIIKSHVPVLIG-PSVPHSIIQPIADELKSPL--------YS 209 Query: 231 VTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRF 290 V+ GT N Q N A A AL+ L++ E I+ G+ A LP R+ Sbjct: 210 VS----------GTFFN-----PEQENCAIAERALQH--LQLQEENIQQGLL-ACLPCRY 251 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 + + + + DVAHNP E L R + V G +KD+ L + Sbjct: 252 EKIQTNIPIFLDVAHNPAGVEGLLKRARKDYSGVPFHIVCGFSRNKDLQTCLHLIAQEAK 311 Query: 351 DWYCAPLEGPRGATAEQL------LEHLGNG-KSFDSVAQAWDAAMADAKAE-DTVLVCG 402 Y G + A +L HL S S+ QA AM +A + VL+CG Sbjct: 312 HIYLVSSTGEKAAPVSKLEAIIRTFVHLPEEIHSHLSIQQAVILAMRNASQDGGIVLICG 371 Query: 403 SFHTV 407 +F+ + Sbjct: 372 TFYIM 376 >UniRef50_C7NET4 FolC bifunctional protein n=3 Tax=Leptotrichia RepID=C7NET4_LEPBD Length = 455 Score = 171 bits (434), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 111/400 (27%), Positives = 186/400 (46%), Gaps = 35/400 (8%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 +AGTNGKG+T LE+I A GY V ++SPH++++ ER+ + + + + + + Sbjct: 51 IAGTNGKGSTATFLENIFFAGGYSVAKFTSPHILKFNERILINKKMISDEDVVKYYEVVM 110 Query: 114 S--ARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIAL 171 + + +FE T AL F++ D + LE GLGGR DATN+V++ +AV+T+I+ Sbjct: 111 DILEKNSFQINFFEIATFMALLYFEEKNPDFIFLETGLGGRYDATNVVNSTIAVITNISF 170 Query: 172 DHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRR---GVE 226 DH LG + I KAGI ++ + I + PE+ + + +L++ VE Sbjct: 171 DHVSLLGNSLDKIADRKAGIIKNRQLCIYAQNLPELENAVKKETDNSVNILKKYENLQVE 230 Query: 227 W---NYSVT---------DHDWAFSD---AHGTLENLPLPLVPQPNAATALAALRASGLE 271 NY D D H + LPL + A L A + + Sbjct: 231 LDTQNYKTIVKILESENLDESENIEDKKNKHNLEKTFILPLFGKFQANNFLIAYEIAKIY 290 Query: 272 -VSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVI 330 +S+ I+ G+ L GRF+I S P I DVAHN + L + L KN V+ ++ Sbjct: 291 GISDEIIQKGLDEISLAGRFEIFSPKPITILDVAHNHDSVRVLVENLNELFKNDEVIFIL 350 Query: 331 GMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQLLEHLGNGKSF-------DSVA 382 +L KDIA + + L E G +A ++ ++L N D++ Sbjct: 351 SILGTKDIANIFEKILEKNYKIFITSLKEVTYGLSANEIKKNLENSNILTNNIIFEDNIL 410 Query: 383 QAWDAAMADAKAEDT----VLVCGSFHTVAHVMEVIDARR 418 A++ A +++ ++VCGSF+ +A ++ R Sbjct: 411 DAYNQAKQMVLQKNSRYKAIVVCGSFYEIAKFKKLCGKRN 450 >UniRef50_B2A1F3 FolC bifunctional protein n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A1F3_NATTJ Length = 465 Score = 171 bits (434), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 132/456 (28%), Positives = 213/456 (46%), Gaps = 62/456 (13%) Query: 16 WLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 W+ L+ SK GLER++ + L V VAGTNGKG+TC LES+L + G Sbjct: 11 WIQNLDKFGSKP---GLERINWLLTELNHPHNHYPVIHVAGTNGKGSTCSILESLLSSMG 67 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE------SARGDISLTYFEYGTL 129 Y+VG+++SP + + ERV + + ++ EI+ A+G T FE T Sbjct: 68 YQVGLFTSPFIDDFAERVTCNSKPITKTELGELVCEIKPIVEAAEAKGLGHPTQFEVITA 127 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 AL F++ D+VILE GLGGRLDATN+V ++++TSI DH + LG I EKA Sbjct: 128 LALLYFQKKSPDMVILETGLGGRLDATNVVTPVLSIITSIGYDHINVLGNTLTKIAEEKA 187 Query: 190 GIFRSEKPAIVG------------EPEMPSTIADVAQEKGALLQRRGVEWNYSV-----T 232 GI + P I G + + S I + Q+KG+ L WNY + T Sbjct: 188 GIIKENIPVITGLHQDKASIEEDTQEQAFSVIEEKCQKKGSPLYASERNWNYRIKAFSST 247 Query: 233 DHDWAFSDAHGTLENLPLPLVPQ---PNAATALAAL----RASGLEVSENAIRDGIASAI 285 + + + NL LPL+ + NA+ AL AL + E+ N +R G+ Sbjct: 248 GYCFDYFGLEAEFINLKLPLLGESQIKNASMALCALELLKKQGWNEIDWNDMRKGMVRVN 307 Query: 286 LPGRFQI--------------VSESPRVIFDVAHNPHAAEYLTGRMKALPKN---GRVLA 328 +P R + + P V+ D +HNP + + L ++ L N +++ Sbjct: 308 IPARMEFWPADSGEKTITGSRAEKQPDVLLDASHNPPSVQNLMSCIRRLDTNRKWNKIVF 367 Query: 329 VIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVA------ 382 V G+L DK + +A + D+ + R +A LL+++ + +++ Sbjct: 368 VTGVLQDKPMEKIVANFSLIPDEIVVTEPQNTRALSAHCLLDYITDQLPDTNISVESDLY 427 Query: 383 QAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 +A ++ A +++ GSF+ V++ARR Sbjct: 428 KAVRMGISKAGNGSLLVIFGSFYL------VVEARR 457 >UniRef50_B9LS84 Dihydropteroate synthase n=5 Tax=cellular organisms RepID=B9LS84_HALLT Length = 878 Score = 171 bits (434), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 146/431 (33%), Positives = 205/431 (47%), Gaps = 41/431 (9%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 ++L +L ++ G ERV+ + ++G + VAG+NGKG+T R ESIL AG Sbjct: 8 AFLFDLRRFSVKPGTERVAALLDQVGNPEEDVSFVQVAGSNGKGSTARMTESILREAGLS 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAE------IESARGDISLTYFEYGTLSA 131 VG+Y+SPHL +RVRV G + E+A A F E +E A LT+FE T A Sbjct: 68 VGLYTSPHLSALADRVRVDGLAMTEAA-IADFVEEVKPWLVERAANGEPLTFFEVVTAMA 126 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 + F + ++DV +LEVGLGG DAT+ VD VT+++L+HT LG I R KA I Sbjct: 127 IHDFARREVDVAVLEVGLGGEYDATSAVDPVATAVTNVSLEHTAVLGDTIAEIARTKARI 186 Query: 192 FRSEKPAIVG-EPEMPSTIADVAQEKGA----LLQRRGVEWNYSVTDHDWAF-------- 238 + P + E E S + +VA + GA + + G N D + Sbjct: 187 ADAGVPLVTACEGEALSVVREVANDAGAPIATVARASGSSGNGETDDQTLSVAYEGRVSP 246 Query: 239 SDAHGTLE-----NLPLPLVPQ---PNAATALAALR------ASGLEVS--ENAIRDGIA 282 +DA TL +PLV NA A+A R +G + S + A+RDG+A Sbjct: 247 TDAEVTLAGEVDGTYRIPLVGDHQATNAGIAVALARRTAGALGNGTDASLPDEAVRDGLA 306 Query: 283 SAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTL 342 A PGRF++V +P + D AHNP A L G + + L V G +HDKD G Sbjct: 307 RATWPGRFEVVDTAPLTVLDGAHNPAACRTLAGTLAEYDYDDLHL-VYGAMHDKDHVGAA 365 Query: 343 AWLKSVVDDWYCAP----LEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTV 398 + L C P E P A + + + D VA A + A+ A D V Sbjct: 366 SALPDADSAVTCRPDLDRAEDPEVLAAALRTAGVDDVTAGDDVAAALETAVERADLGDCV 425 Query: 399 LVCGSFHTVAH 409 L+ GS VA Sbjct: 426 LLVGSLFAVAE 436 >UniRef50_Q2LQC5 Folylpolyglutamate synthase / dihydrofolate synthase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LQC5_SYNAS Length = 465 Score = 171 bits (434), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 119/404 (29%), Positives = 193/404 (47%), Gaps = 14/404 (3%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 L +L+ I LGL+ + + R+ + + GTNGKG+T L IL +GYKVG Sbjct: 41 LLDLNCNIIRLGLDPIRHLLERMENPQLKYPAVLIGGTNGKGSTAAILSCILKESGYKVG 100 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQ 139 +Y+SPHL ER+R+ G + E F I+S+ + LTYFE T SA F Q + Sbjct: 101 LYTSPHLTSICERIRINGSLISEERMQDCFGMIQSSLEE-PLTYFEVLTASAYLYFYQEK 159 Query: 140 LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI 199 +D+ +LEVG+GGRLDATN+V V+V++++ L+H ++LG I EKAGI + + Sbjct: 160 VDIAVLEVGMGGRLDATNVVTPLVSVISNVHLEHQEYLGRHLRDIAAEKAGIIKENSVCV 219 Query: 200 --VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT-DHDWAFSDAHGTLENLPLPLV--- 253 V + + +++ ++K A L R G + V D +++ L++L L Sbjct: 220 TAVTQKAVLDLLSETCRQKEATLYRLGKDIRVRVKGDGTFSYQGIAIKLDDLKCTLSGAH 279 Query: 254 ---PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 A A + G+ V+ A+ G+A A GR +I+ +P V+ D AHNP AA Sbjct: 280 QIKNAALALAAAEVVTTKGIRVNRQAMLSGVACASWDGRLEILQNTPTVLVDGAHNPAAA 339 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 L ++ + L + G L DK+ L L D + R L+ Sbjct: 340 NVLCQALRNRNADDHRLLIFGALGDKNYRLMLKKLLPFFDHVIFTKPKTERAVDVADLIR 399 Query: 371 ----HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 + + ++ + +A A+ D + + GS + V + Sbjct: 400 AARHYDRSAEAIEDSCEALQRALCLTGKNDMICITGSLYLVGEI 443 >UniRef50_P15925 Folylpolyglutamate synthase n=9 Tax=Lactobacillus RepID=FOLC_LACCA Length = 428 Score = 171 bits (434), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 114/387 (29%), Positives = 193/387 (49%), Gaps = 33/387 (8%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHT------- 106 V GTNGKG+ + +L A+G VG+Y+SP ++R+ ER+ + + +P++A Sbjct: 44 VTGTNGKGSAANAIAHVLEASGLTVGLYTSPFIMRFNERIMIDHEPIPDAALVNAVAFVR 103 Query: 107 ASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVV 166 A+ ++ + D ++T FE+ T W F+Q Q+DV ++EVG+GG D+TN++ V+V+ Sbjct: 104 AALERLQQQQADFNVTEFEFITALGYWYFRQRQVDVAVIEVGIGGDTDSTNVITPVVSVL 163 Query: 167 TSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVE 226 T +ALDH LG +I + KAGI + P + G + + D A A + G + Sbjct: 164 TEVALDHQKLLGHTITAIAKHKAGIIKRGIPVVTG-----NLVPDAAAVVAAKVATTGSQ 218 Query: 227 W-----NYSVTD---HDWA----FSDAHGTLENLPLPLV---PQPNAATALAALRASGLE 271 W ++SV H W + D G + +L +PLV Q N A A+ + + Sbjct: 219 WLRFDRDFSVPKAKLHGWGQRFTYEDQDGRISDLEVPLVGDYQQRNMAIAIQTAKVYAKQ 278 Query: 272 ----VSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVL 327 ++ IR G+A++ P R + +S++P ++ D AHNP L +K L + Sbjct: 279 TEWPLTPQNIRQGLAASHWPARLEKISDTPLIVIDGAHNPDGINGLITALKQLFSQ-PIT 337 Query: 328 AVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDA 387 + G+L DKD A L + Y P+ G A E E L G+ DS +A A Sbjct: 338 VIAGILADKDYAAMADRLTAAFSTVYLVPVPGTPRALPEAGYEALHEGRLKDSWQEALAA 397 Query: 388 AMADAKAEDTVLVCGSFHTVAHVMEVI 414 ++ D + +++ GS + + V + + Sbjct: 398 SLNDVP-DQPIVITGSLYLASAVRQTL 423 >UniRef50_C6D869 FolC bifunctional protein n=3 Tax=Bacillales RepID=C6D869_PAESJ Length = 458 Score = 171 bits (433), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 111/345 (32%), Positives = 176/345 (51%), Gaps = 29/345 (8%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GL+R+ + RL +AGTNGKG+TC L S+LM GY VG ++SP++ ++T Sbjct: 35 GLDRIEQLLERLNNPHRRLKFIHIAGTNGKGSTCAYLTSVLMKCGYDVGTFTSPYITKFT 94 Query: 91 ERVRVQGQELPE----------SAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQL 140 R + GQ++ E +H AE E S T FE T A+ + Sbjct: 95 NRFQYNGQDIDEETLLRLSNVLKSHVEELAETEFG----SPTMFEVSTALAILFYATVTY 150 Query: 141 -DVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI 199 D V+ E GLGGR+D TNIV ++V+T++ DH D LG E++ EKAGI ++ P + Sbjct: 151 PDYVVWETGLGGRMDVTNIVTPIISVITNVGHDHMDRLGDTLEAVAFEKAGIIKAGVPVV 210 Query: 200 --VGEPEMPSTIADVAQEKGALLQRRGVEWNYS-----VTDHDWAFSDAHGTLENLPLPL 252 V +PE+ + A EK + L G ++N + + F +++ L + L Sbjct: 211 SAVDQPEVVEVVKRTAAEKKSTLYLLGDQFNIKELSSEEDEQTFRFEGMFRSIDPLTITL 270 Query: 253 V---PQPNAATALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 + NAA A+ L + L V ++A+ DG+ A PGR ++VS SPR++ D AH Sbjct: 271 NGAHQRTNAAVAVMTLEVLRQYYALIVEDDALADGLREAKWPGRLEMVSRSPRILIDGAH 330 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 NP AE L +++ + R+ ++ M+ +K+ L + +VD Sbjct: 331 NPEGAESLVQALRSTYRYDRLHVMMAMVENKNHRDVLKHILPIVD 375 >UniRef50_A8YUM7 Folylpolyglutamate synthase n=28 Tax=Lactobacillus RepID=A8YUM7_LACH4 Length = 424 Score = 171 bits (433), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 113/411 (27%), Positives = 201/411 (48%), Gaps = 22/411 (5%) Query: 16 WLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 +L L ++H K DL + + +LG + + GTNGKG+T L +++ AG Sbjct: 12 YLYSLPHVHPKN-DLSF--IKKLLQQLGNPQDQVKTIHITGTNGKGSTSYYLANLVKKAG 68 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPES-----AHT--ASFAEIESARGDISLTYFEYGT 128 + G++ SP++ R+ ER+++ Q++ + A+T A++ +++ SL FEY Sbjct: 69 QRTGLFVSPYVYRFNERIQLNNQDISDEDLVNVANTVQAAYEKLKQEDEQFSLVTFEYEV 128 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 A F+Q Q D ++EVG+GG D TN++ +V+++T+I LDH +GP + I +EK Sbjct: 129 AMAFVYFEQKQCDYAVIEVGIGGEHDKTNVIIPEVSIITTIGLDHEKIIGPTIQDIAQEK 188 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEK-----GALLQRRGVEWNYSVTDHDWAFSDAHG 243 +GI + +P ++G +P ++ + +K LLQ + ++ + +SDA Sbjct: 189 SGIIKQNRPVVLG--NVPDSVLSILVKKADKMHAPLLQLKH-DFTIETQNGRLKYSDAKR 245 Query: 244 TLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 +L P V + A A+ A L +++ I D I +PGR+ I+ + P +I D Sbjct: 246 SLSFAYRPQVEGYDIAVAVKAFLLLKLNLNDQEIEDAINQTQIPGRYHILQKEPLIILDG 305 Query: 304 AHNPHAAEYLTG--RMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 AHN A L +A ++ V A++ M+ DKD+ + D L+ PR Sbjct: 306 AHNIQAMSNLLEVVHAEAKKRHSHVYALVTMMKDKDLEQVFSLFNK-DDQVLLTTLDYPR 364 Query: 362 GATAEQLLEHLGNGKSFD-SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 A + S++ Q + A D +LV GSF+ V+ ++ Sbjct: 365 VAKENDFPIDIQRRYSYEGDYRQGFTKLKEKMDASDILLVTGSFYLVSAIL 415 >UniRef50_C1I5V8 FolC bifunctional protein n=1 Tax=Clostridium sp. 7_2_43FAA RepID=C1I5V8_9CLOT Length = 432 Score = 171 bits (433), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 124/433 (28%), Positives = 204/433 (47%), Gaps = 43/433 (9%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + YLE L + GLER + LG + +AGTNGKG+T L +L+ GY Sbjct: 7 IKYLEELRVLGSNYGLERTERLLELLGNPHKKLKLIHIAGTNGKGSTSSILGKVLIEHGY 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE------SARGDISLTYFEYGT-L 129 KVG ++SPHL E +RV + +PE EI+ G T FE T + Sbjct: 67 KVGFFNSPHLEEIEETIRVNDENIPEEDLVYLLEEIKPYVNKVVEEGYKHPTEFEVLTCI 126 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 L+L++Q ++D ++EVGLGGRLD+TN++ ++++TSI+LDHT+ LG + I EKA Sbjct: 127 MFLYLYRQ-KVDFGVIEVGLGGRLDSTNVIKPILSIITSISLDHTNILGNTIQEITNEKA 185 Query: 190 GIFRSEKPAIVGEPE-------------MPSTIADVAQEKGALL---------QRRGVEW 227 GI + P I + S + V L QR V + Sbjct: 186 GIIKDAIPVITCNQKDEALYIIKNKALLTKSKLTIVDSNDFVFLEIVNDDIPYQRVSVNF 245 Query: 228 NYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAAL-RASGLEVSENAIRDGIASAIL 286 N + D A H + NL L A AL L + + ++V+ N + G+ + Sbjct: 246 NNNKYTLDLALLGKHQII-NLSL-------AIKALEELEKLNYIKVNINKLYKGVKNVKW 297 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 GR +++ + P ++ D AHN E+L ++ K + ++G+L DK++ + + Sbjct: 298 KGRLEVLKKDPFIVIDGAHNIAGIEFLKSNIEEYFKYKNLYLILGILADKNVEEMVKIIA 357 Query: 347 SVVDDWYCAPLEGPRGATAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCG 402 V + Y R A+A +L LE+ N +FD +A +++ A +D ++ G Sbjct: 358 PVATEVYTVTANSIRAASANELKEVVLEYNNNCIAFDDYDKAIKLSLSKANKDDLIVAAG 417 Query: 403 SFHTVAHVMEVID 415 S + + + + I+ Sbjct: 418 SLYMIGEIRKQIN 430 >UniRef50_D1AJ52 FolC bifunctional protein n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AJ52_SEBTE Length = 407 Score = 171 bits (433), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 111/395 (28%), Positives = 186/395 (47%), Gaps = 13/395 (3%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 L+++ I LGLE + LG + + +AGTNGKG+ LE+ L+ AGYK G Sbjct: 7 LDSIDKNKIKLGLETMEKSLKILGNPERNYKIIHIAGTNGKGSAAAFLEAGLIEAGYKTG 66 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR--GDISLTYFEYGTLSALWLFKQ 137 Y+SP + R+ ER+ + +E+ + + ++ A DI LTYFE T K Sbjct: 67 KYTSPEIYRFNERITINREEISDGDVELYYEKVNKALELSDIKLTYFEITTAMMFLYMKD 126 Query: 138 AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKP 197 +D ++LE GLGGR DATN V ++++T+++ DH ++LG I EKAGI + + P Sbjct: 127 KNIDYLVLETGLGGRTDATNTVTPVISLITNVSFDHMEFLGNTLREIAHEKAGIIKKDIP 186 Query: 198 AIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQ 255 + PE+ I + +L++ N + D + + + L L + Sbjct: 187 VFFADDNPELLEEIKAKTENYINVLKKYEFNENSTKLDKEKLNTLVKINNKEFRLSLFGK 246 Query: 256 PNAATALAALRA-SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLT 314 L A A L + + I+ + + GRFQI +E+P +I D AHN +A L+ Sbjct: 247 FQGKNFLLAYEALKYLGIDDEVIKRACSETVWNGRFQIAAENPFIILDGAHNKDSAAVLS 306 Query: 315 GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN 374 ++ + N ++ +I +L DKD L L D + RG + +++ Sbjct: 307 ESLREVFPNKELVYIISILRDKDNESILEELAKASDYAVFTGINNNRGQSCDEM---YNK 363 Query: 375 GKSFDSVAQAWDAAMADAKA-----EDTVLVCGSF 404 GK + + A + + K + ++CGSF Sbjct: 364 GKKYFKHSYAENTPESALKKAVSLNKKATVICGSF 398 >UniRef50_UPI0001745D4D FolC bifunctional protein n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI0001745D4D Length = 413 Score = 171 bits (432), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 132/410 (32%), Positives = 190/410 (46%), Gaps = 46/410 (11%) Query: 28 IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLV 87 I LGLE + + + VAGTNGKG+ C L S+L AA G+++SPHL+ Sbjct: 23 IKLGLENTRKLLDDMKLPMGGQKFLHVAGTNGKGSVCAFLHSLLKAAEVNAGLFTSPHLI 82 Query: 88 RYTERVR-----VQGQELPESAHTASFAEIESARG-----DISLTYFEYGTLSALWLFKQ 137 + ER+R + QE+ E+++ R D T+FE AL F++ Sbjct: 83 HFRERIRDAERTITSQEI--------VKEVDALRKRVEGWDPHPTFFELTFALALDWFRK 134 Query: 138 AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKP 197 +L+ V+LE G+GGRLDATN V V+TSI+LDH LG I EKAGI + P Sbjct: 135 QELEWVVLETGMGGRLDATNTVLPAACVITSISLDHQQHLGATLREIATEKAGIIKPGVP 194 Query: 198 AIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQ 255 I + PE+ ++D A+E+GA L S L L L Q Sbjct: 195 VITLKQAPEVMQVLSDTARERGAPL------------------SIVTTPLRGYQLGLFGQ 236 Query: 256 P---NAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEY 312 NA A+AA +A+G SE +R G+ + P RFQ E R+I D AHNP AAE Sbjct: 237 HQLWNATLAVAAFKAAGFRASEPVLRVGLKTVEWPARFQ-REEQDRLIIDGAHNPDAAET 295 Query: 313 LTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL 372 L + V G + +KD + L+ + W+ + PR E L + L Sbjct: 296 LVRTWHQAFPGEKASVVFGAVSNKDAKAVMRSLQPIASHWHFTRFDSPRAMAPEDLRKEL 355 Query: 373 GN---GKSFDSVAQAWDAAMADAKAE-DTVLVCGSFHTVAHVMEVIDARR 418 + SV + + A+A A+ + VLV GS + V+ ++ R Sbjct: 356 ADLYASAVNCSVHETIEDALAKARHNAERVLVTGSLYLAGEVISILRGER 405 >UniRef50_Q13EP9 FolC bifunctional protein n=37 Tax=Alphaproteobacteria RepID=Q13EP9_RHOPS Length = 448 Score = 171 bits (432), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 143/436 (32%), Positives = 205/436 (47%), Gaps = 29/436 (6%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVS-LVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 PQ ++ + + L LH IDL L R+ L+AA + P V +AGTNGKG+T Sbjct: 7 PQPSALVGELRARLAQLHPAQIDLTLGRIERLLAALDHPQRRLPPVIHIAGTNGKGSTLA 66 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQ----GQELPESAHTASFAEIESARGDISL 121 L +IL AAG V Y+SPHLVR E VR+ G + + A+ A E + Sbjct: 67 FLRAILEAAGLSVHAYTSPHLVRVNETVRLGRPGGGALVSDDEFAAALAHCERVNQGAPI 126 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPD 180 T FE T +ALWLF Q DV +LEVGLGGRLDATN++D +A V+T I +DHT++LGP Sbjct: 127 TLFEIETAAALWLFAQHPADVTLLEVGLGGRLDATNVIDQPLACVLTPIGIDHTEFLGPT 186 Query: 181 RESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF 238 I EKAGI R P IV + + I A+ A L RG +W+ V A+ Sbjct: 187 LADIAAEKAGIIRRGVPVIVAGQQNDAMDVIEREAERLRAPLHARGQQWHVEVEHGRLAY 246 Query: 239 SDAHGTLENLPLPLVPQ---PNAATALAALRASG-LEVSENAIRDGIASAILPGRFQ--- 291 D G ++ L + NA A+A LRA + A + G+ SA P R Q Sbjct: 247 QDDRGLMDLTAPKLFGRHQIDNAWLAIATLRAQQRFTFDQAAYQAGLLSADWPARMQRLT 306 Query: 292 ---IVSESP---RVIFDVAHNPHAAEYLTGRMKALPKN-GRVLAVI-GMLHDKDIAGTLA 343 ++ E+P + D HN + L + R L +I GM+ +KD + L Sbjct: 307 TGRLIDEAPPGSELWLDGGHNADGGRVAAAALGDLEERVSRPLVIIAGMMANKDASAFLT 366 Query: 344 WLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFD-SVAQAWDAAMADA-----KAEDT 397 + P+ GA + L G +A + +AA++ + Sbjct: 367 NFTGLTRHVIAVPIPDRDGAMPPEKLADAGRALGLRVELADSVEAALSRIAGLAYELPPR 426 Query: 398 VLVCGSFHTVAHVMEV 413 +L+ GS + HV+ + Sbjct: 427 ILITGSLYLAGHVLRL 442 >UniRef50_C8QY00 FolC bifunctional protein n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QY00_9DELT Length = 453 Score = 170 bits (431), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 133/431 (30%), Positives = 195/431 (45%), Gaps = 44/431 (10%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL+ L I LGL+ + ARLG + VAGTNGKG+ L ++L AGY+V Sbjct: 9 YLDRLQFFKIKLGLDSMERFLARLGKPQQQLRFIHVAGTNGKGSVAAALLAVLSRAGYRV 68 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQA 138 G+Y+SPHL ER R+ + + + I GD +TYFE+ T AL F Sbjct: 69 GLYTSPHLSCVRERFRINDEFIGKDEFARHATAIHEVLGDDQITYFEFTTALALLWFAAR 128 Query: 139 QLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPA 198 ++DV ILEVGLGGRLDATN++ +V V+T+++LDH +LG + EKAGI ++ P Sbjct: 129 RVDVAILEVGLGGRLDATNVITPEVGVITNVSLDHQAYLGDTLAEVAAEKAGIIKAGVPL 188 Query: 199 IVGEPEMPSTIADVAQEKGALLQR------RGVEWNYS-------------------VTD 233 + G S +V +++ LL+ R W Y Sbjct: 189 VTGVAADESR--EVVEQRCRLLKAPCYLLGRNFSWAYGDDRQARQDSAQSVSDSAAAAAG 246 Query: 234 HDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLE-----VSENAIRDGIASAILPG 288 + W + +G + L L + AL L V+E +IR GIA+ PG Sbjct: 247 NLWHYRGLNGEISGLQCRLRGRHQRDNLSLALATLELLAPIWPVTEESIRAGIAAVNWPG 306 Query: 289 RFQIVSESP-------RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGT 341 R + + P RV+ D AHNP L G ++ R++ V + DKD+A Sbjct: 307 RLEYLEIRPAGADGRRRVLLDGAHNPAGIGALVGALQEDFSYRRLVVVWASMADKDVAAG 366 Query: 342 LAWLKSVVDDWYCAPLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAED 396 L + + D+ E R AT + + L + + A A A + +D Sbjct: 367 LQQIAPLADELVLTRPESERSATPAAMRQMLPPATRTAAREAEDTAGALQLAWQASTPDD 426 Query: 397 TVLVCGSFHTV 407 VLV GS + V Sbjct: 427 LVLVAGSLYLV 437 >UniRef50_D1BNH4 FolC bifunctional protein n=3 Tax=Veillonella RepID=D1BNH4_VEIPT Length = 435 Score = 170 bits (431), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 129/414 (31%), Positives = 196/414 (47%), Gaps = 25/414 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L+YLE S I GLER++ + LG + + V GTNGKG+ + L +G Sbjct: 7 LAYLEQASSFGIKPGLERITALMDVLGNPQEDYKIVHVTGTNGKGSVTSYISYALFTSGL 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYGTLS 130 +VG ++SPHL YTER+++ + E A + ++ A I + T FE T + Sbjct: 67 RVGRFTSPHLQSYTERIQINDGNITEEAFGELISRVKGAVDTIVSNGIEAPTQFEMLTAA 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A FK+ +D ++EVGLGG LD+TNIV V+V+T++ +DH + G E I R KAG Sbjct: 127 AFLFFKEQGVDYAVVEVGLGGLLDSTNIVTPKVSVITNVTIDHQAYCGDTVEEIARHKAG 186 Query: 191 IFRSEKPAIVGEPEMP-STIADVAQEKGALL----QRRGVEWNYSVTDHDW---AFSDAH 242 I + + P + + P + I DVA+++ A L + G++ +VT + +DA Sbjct: 187 IIKPKVPVVTAAQDTPLNIIEDVAKKQHAKLYVFNKDFGIDSRSAVTGGQMITVSTNDAA 246 Query: 243 GTLENLPLPLVPQP-NAATALAALR---ASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 + + + Q N A AL A+R +SE +R+G A GRF++ R Sbjct: 247 PAMLFTTMAGIHQSVNLACALMAVRLLMKEDTNISEETMREGFARTTWAGRFEVKRGLDR 306 Query: 299 V-IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 IFD AHN AE L K+ V+ +L DKD + + V D P Sbjct: 307 TFIFDGAHNAAGAESFAMTYDELFKDSPKTIVMAILKDKDQEAIIREVVKVGDTVLVVPA 366 Query: 358 EGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 R E L+E + ++ DS+ A A K D + VCGS + Sbjct: 367 PTDRTEVPETLVEMIRRTVPKATAQTADSIEAALALAYKHTKTGDIIAVCGSLY 420 >UniRef50_Q6AJ73 Related to folylpolyglutamate synthase n=3 Tax=Deltaproteobacteria RepID=Q6AJ73_DESPS Length = 441 Score = 170 bits (430), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 132/421 (31%), Positives = 210/421 (49%), Gaps = 25/421 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L++L++L I LGL + A + V VAGTNGKG+ C +L S+L GY Sbjct: 18 LAFLDSLQFHKIKLGLAPMRDFLALFDNPEAKMKVVHVAGTNGKGSVCSSLVSVLAKGGY 77 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT-LSALWLF 135 ++G+Y+SPHL ER R+ + + + I + +TYFE+ T L+ LW + Sbjct: 78 QLGLYTSPHLSSPRERFRINDEYISRADFACLTDRIRTRLAGRPITYFEFTTALAFLWFY 137 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIFRS 194 ++ +D+V+LE GLGGRLDATN+V + ++TSI++DH +LG E++ EKAGI + Sbjct: 138 ERG-VDLVVLETGLGGRLDATNVVRQPLLTIITSISIDHVAYLGDTIEAVASEKAGIIKE 196 Query: 195 EKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWN-YSVTDHDWAF------SDAH-GT 244 P + G +P++ + +A A+EK A L G +++ + + W + +DA Sbjct: 197 GVPVVCGSYDPKVVAVVAGFAREKKAPLYLAGRDFDAHWLAGASWDYQGEGFLADASLQA 256 Query: 245 LENLPLPLVPQPNAA---TALAALRASGLEVSENAIRDGIASAILPGRFQIVS--ESPR- 298 +EN + N A T L L+ G VSE+ +R G+ S PGR + + SP Sbjct: 257 VENAKPGRIQAENGALVLTTLCLLKRHGFVVSEDELRSGLFSVSWPGRLEYLQLDRSPAP 316 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 + D AHNP L + AL R++ V G + DKDIA L + VD ++ Sbjct: 317 YLLDGAHNPAGIASLVEAL-ALYSYRRLICVWGAMADKDIATGLNRIVPHVDLLCLTAVD 375 Query: 359 GPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 R A + L F S + A + A A +D +L+ GS + + + + Sbjct: 376 SERAAEPAAMFALLTEDDRKKTTCFTSSSLALEYAERMAGKDDLILIAGSLYLMGELRPI 435 Query: 414 I 414 + Sbjct: 436 L 436 >UniRef50_A9BIJ6 FolC bifunctional protein n=1 Tax=Petrotoga mobilis SJ95 RepID=A9BIJ6_PETMO Length = 438 Score = 170 bits (430), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 129/416 (31%), Positives = 205/416 (49%), Gaps = 33/416 (7%) Query: 28 IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLV 87 + LGLER+ ++ R+G + + GTNGKG+ + IL G KVG Y SPHLV Sbjct: 20 VKLGLERIDELSKRIGSPQNTFKSIHITGTNGKGSVTTAISRILRFNGMKVGTYISPHLV 79 Query: 88 RYTERVRVQGQELPESAHTASFAEIESARGDISL-------TYFEYGTLSALWLFKQAQL 140 TER++V G+ + E + EIE + L ++FE T A F++ ++ Sbjct: 80 SITERIKVNGENISEKEFVEIYNEIEEEIKTMDLKGEEYAPSFFEITTAMAFKYFEKQKV 139 Query: 141 DVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV 200 DV + EVGLGGRLDATNI+++DV+V+TSI+ DH LG E+I EKAGI + I+ Sbjct: 140 DVGVFEVGLGGRLDATNIINSDVSVITSISKDHIKTLGDTLEAIAYEKAGIIKKNNFLIL 199 Query: 201 GE-PEMP-STIADVAQEKGA-LLQRRGVEWNYSVTDHDWAFS----DAHG---TLENLPL 250 G E P I + A+E A + G ++ YS+ +H + + D HG +++L Sbjct: 200 GNIDESPKKVILNKAKEVNAEKIYEHGKDF-YSI-NHRYFINNNMLDYHGLNYEIKDLIF 257 Query: 251 ---PLVPQPNAATALAA----LRASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFD 302 N T+LAA ++ G +S +R+ +A+ GRF+ +++FD Sbjct: 258 GANGTFQIENVTTSLAATEAFMQKFGKTLSIEKVREAMANFYWEGRFEYTEINGKKMVFD 317 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 AHN AA+ L + + +A+IG+L DKD SV D + RG Sbjct: 318 GAHNLAAAQQLEKSVNLYFPTQKKIALIGILDDKDYEKMSQIFASVFDKIIVTSVPSERG 377 Query: 363 ATAEQLLE----HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 E + E H N + ++ ++ +++ D V GS + + + E++ Sbjct: 378 RHPELIYEEFKKHTKNVEFIKDPSEGFNKLLSE--KSDIYFVTGSLYLLGKMKELM 431 >UniRef50_A5I6P2 FolC bifunctional protein n=14 Tax=Clostridia RepID=A5I6P2_CLOBH Length = 429 Score = 170 bits (430), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 115/415 (27%), Positives = 201/415 (48%), Gaps = 34/415 (8%) Query: 29 DLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVR 88 +LGLER + LG +AGTNGKG+T + ++L +GYKVG+Y+SP++ Sbjct: 19 NLGLERTEKLLELLGNPHKRLRCIHIAGTNGKGSTTAMISAVLKESGYKVGMYTSPYIEE 78 Query: 89 YTERVRVQGQELPES------AHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDV 142 + ER+++ G + + A+ E G + T FE T++ + F ++D Sbjct: 79 FEERIQINGHNITKEDLGYIITKVANIVEKVENMGYGNPTEFEIITVAMFYYFCLKEVDF 138 Query: 143 VILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE 202 ++EVGLGGRLD+TN+++ ++++TSI+ DH + LG E I EKAGI + K ++ Sbjct: 139 AVIEVGLGGRLDSTNVLEPILSIITSISYDHMNILGETLEEITYEKAGIIK--KAPVITY 196 Query: 203 P---EMPSTIADVAQEKGALLQRRGVEWNY----------SVTDHDWAFSDAHGTLENLP 249 P E+ I V +EK L + VE N ++ + T N+ Sbjct: 197 PQKKEVEKNIEKVCKEKNCELIK--VEDNLINIEIEIIEKNMGQQSFKLKTKEDTY-NIC 253 Query: 250 LPLVPQ---PNAAT---ALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 L L+ + N T AL L G+++ + I + P R +IV+++P + D Sbjct: 254 LSLLGEHQIKNCITVILALEKLMKLGIKIEKIHIISALKKVKWPARLEIVNKNPLTVIDG 313 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 AHN E L + K +++ ++G+L DK + + L + D RG Sbjct: 314 AHNIDGIESLKNNVSKYFKYNKLILILGILKDKQVEDMIKTLVPLADRVLTVAPHNDRGE 373 Query: 364 TAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 ++++L L+H + + + + +D A + D +L+CGS + V + ++I Sbjct: 374 SSKELMHIVLKHNESCEHLEDYKECYDKAKFYCEDGDMILICGSLYMVGDMRKLI 428 >UniRef50_UPI0001BC3950 FolC bifunctional protein n=1 Tax=Butyrivibrio crossotus DSM 2876 RepID=UPI0001BC3950 Length = 428 Score = 170 bits (430), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 126/394 (31%), Positives = 194/394 (49%), Gaps = 32/394 (8%) Query: 51 VFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFA 110 V +AGTNGKG+T ++ IL G G YSSP ++ E +R+ G+ + + Sbjct: 41 VIHIAGTNGKGSTGAFIDKILTNTGLTTGRYSSPAVMEPLEIIRINGKNIGCEDFSEVVT 100 Query: 111 EIESAR-----GDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADV-A 164 E+++AR +I T FE T SA F + ++DV I+E G+GG LDATN+ + + + Sbjct: 101 EVKAARERLAEDNIYPTRFEVETASAFLFFSRKKVDVAIIECGMGGLLDATNVFEEVLCS 160 Query: 165 VVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRG 224 V+TSI++DHTD+LG E I KAGI + P + + +A V +++ AL + Sbjct: 161 VITSISMDHTDFLGDTLEKIAFNKAGIIKDHCPVVTCNRD--EAVAKVIEQEAALKKAPL 218 Query: 225 VEWNYSVTDH------DWAFSDAHGTLENLPLPL---VPQPNAATALAA---LRASGLEV 272 ++ +V + FS + ENL L NAA A+ A L+ SG + Sbjct: 219 IQVKDAVLSEIGSQGPELIFS--YEEYENLKCGLKGIYQTVNAAAAIEAVKVLKNSGYGI 276 Query: 273 SENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGM 332 S++ IRDGI + PGRF+I+ +P VI D AHNP A L+ ++ N + +IG+ Sbjct: 277 SDDNIRDGIENTYWPGRFEIIHNNPLVITDGAHNPDGARALSETLRYYFGNKKHTFLIGI 336 Query: 333 LHDKDIAGTLAWLKSVVDDWYCAPLEGP-RGATAEQLLEHLG-----NGKSFDSVAQAWD 386 DKDI G L + + D+ G R A E + + N + F V Sbjct: 337 FKDKDIYGILDEIMDLADNVIVIETPGNIRAADCEHVASIIKERYSINAEPFKDVKDGVL 396 Query: 387 AAMADAKAEDTVLVCGSFHTVAHVMEVI--DARR 418 + D+V+ GS + + E+I D RR Sbjct: 397 RCL--ELCTDSVVTFGSLSNIKRIKEIIKNDYRR 428 >UniRef50_C9LMI1 Tetrahydrofolate synthase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMI1_9FIRM Length = 440 Score = 169 bits (429), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 131/421 (31%), Positives = 198/421 (47%), Gaps = 31/421 (7%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 +S LE I GLER+ + A LG + A + + GTNGKG+ + S+L Sbjct: 7 ISRLEEASVFGIKPGLERMQKILAVLGNPEKACKMIHITGTNGKGSVAAMITSVLENTNL 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPE----SAHTASFAEIES--ARGDISLTYFEYGTLS 130 +VG ++SPHL+ YTER+ + G+++ A T F + A G+ +LT FE T Sbjct: 67 RVGRFTSPHLIDYTERIYLGGKDISREDFAKAATVVFKAHDELVAAGEEALTEFELLTAI 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A W F++ + D ++EVG+GGR DATN+V V+V+T++A+DH +LG + I REKAG Sbjct: 127 AFWYFRENKADYAVMEVGMGGRFDATNVVMPVVSVITNVAMDHMQYLGNTLQEIAREKAG 186 Query: 191 IFRSEKPAIVGEPEMP-STIADVAQEKGALLQRRGVEWNYSVTDHDW-----AFSDAHGT 244 I + P + + + A K A + G ++ T + W G Sbjct: 187 IIKEGIPVVTAAQHVALKELKKDAHNKKARIYFYGRDFEID-TRNKWEQGQVVVVKRKGM 245 Query: 245 LENLPLPLVPQP-----------NAATALAALRASGLEVSENAIRDGIASAILPGRFQIV 293 + L ++ P AA AL L ++EN +R+G+A A GRF+I Sbjct: 246 PKELEKSMLFVPFIGAHQAVNAAVAAMALTILMKEDGRINENDLREGLARARWQGRFEIH 305 Query: 294 SESPR-VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 + V+ D AHN AE L ++ + R + V L DK + L D Sbjct: 306 HAGGKTVVLDGAHNEAGAEALQEALREQYPDKRRIFVFSSLQDKTTETIIQMLVRKGDKV 365 Query: 353 YCAPLEGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 Y PR T E++ E + K SVA A + A+ +A D VLVCGS + Sbjct: 366 YACAAPTPRTRTPEEICEMIDRQKIRAEHKIAGSVADALEKAVKEADENDIVLVCGSLYI 425 Query: 407 V 407 + Sbjct: 426 L 426 >UniRef50_B3DQR8 Folylpolyglutamate synthase n=18 Tax=Bifidobacterium RepID=B3DQR8_BIFLD Length = 543 Score = 169 bits (429), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 117/350 (33%), Positives = 182/350 (52%), Gaps = 27/350 (7%) Query: 26 KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPH 85 T +L L+R++L+ LG + + V + GTNGKG+T R E+I A G + G+Y+SPH Sbjct: 28 NTTNLDLDRMNLMLDILGHPEQSFRVIHITGTNGKGSTARMAEAICRAYGMRTGLYTSPH 87 Query: 86 LVRYTERVRVQGQELPESA------HTASFAEIESAR----GDISLTYFEYGTLSALWLF 135 L + ER+ + GQ+L + T + A+ G +++FE T A+W F Sbjct: 88 LEKINERIAIDGQQLSDDDFIDIWDQTKDLVALVDAKMEEQGKPKMSFFEVLTAMAIWKF 147 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 +DV I+EVG+GG DATN+++AD A++ + +DH WLG E I EKAGI + Sbjct: 148 ADTPVDVAIVEVGMGGLWDATNVLNADAAIIGPVDMDHMQWLGDTVEQIATEKAGIIKPN 207 Query: 196 KPAIVG-----EPEMPSTIADVAQEKGALLQRRGVEWNYS-----VTDHDWAFSDAHGTL 245 AI+G E MP +A+ A+ A+L R G E S V + +GT Sbjct: 208 CTAIIGPQPHEEAVMP-ILAEAAERNHAMLVRDGYEMTVSDRMAAVGGQVATLTTPNGTY 266 Query: 246 ENLPLPLVPQPNAATALAALRASGLEVSENAIRDG------IASAILPGRFQIVSESPRV 299 E +P+ + A ALAAL AS + + N DG ++S +PGR + + SP + Sbjct: 267 EGVPIAKFGEHQAHNALAALAASEVVIPVNGPLDGDLVGEALSSVKIPGRIEQIRTSPTI 326 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 I D HN +AAE L ++ +++ V+ M+ DK + L L+ ++ Sbjct: 327 ILDGGHNVNAAEALRKAIEESYDFKQLVGVVAMMRDKQVEEYLGVLEPIL 376 >UniRef50_A6C8Q2 Folyl-polyglutamate synthetase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C8Q2_9PLAN Length = 477 Score = 169 bits (428), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 132/438 (30%), Positives = 211/438 (48%), Gaps = 54/438 (12%) Query: 27 TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 T D L R+ + LG + +AGT GKG+T + +L AAG++ G+++SPH+ Sbjct: 31 TSDFKLGRMQELLESLGNPQSEVRTIHIAGTKGKGSTSAMIAEMLSAAGFRTGLFTSPHI 90 Query: 87 VRYTERVRVQGQEL-PE------SAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQ 139 Y ER+ + G+++ PE S +++ G++S T+FE T A F+Q + Sbjct: 91 TCYEERILIDGRQIEPEQLVDLVSELIQVVEQLDLKPGNLSPTFFELTTALAWMHFQQQR 150 Query: 140 LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI 199 +D ++EVGLGGRLD+TN+ + +VVT+I+ DHT LG E I REKAGI + P Sbjct: 151 VDFAVMEVGLGGRLDSTNVCEPLASVVTNISYDHTALLGNTIEQITREKAGIIKQGVPVF 210 Query: 200 VG--EPEMPSTIADVAQEKGA---LLQR---RGVE----WNYSVTDHDWAFSDAH----- 242 G +PE + + +V +EK A LL R R VE + D F D++ Sbjct: 211 SGVTQPEAMAVLEEVCREKQAPLYLLNRDFKRLVEPYQGFRREQADDSRLFPDSNQQTIQ 270 Query: 243 -----GTLENLPLPLVPQPN------AATALAALRASGLEVSENAIRDGIASAILPGRFQ 291 ++ +P+ L+ A T + LR G+ + ++ +R G+ P R + Sbjct: 271 VRTPWSLIDQMPVTLLGTHQLINATLAVTVIDFLRQQGVPLEDSQMRQGMTRLKWPARIE 330 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKA-LPKNGRVLAVIGMLHDKDIAGTLAWL----K 346 +V ++P V+ D AHN + E L + A P+ R+L + DKD+ L L + Sbjct: 331 LVQKNPPVVIDTAHNGASIEALVETLAASFPQTNRIL-IFAATKDKDVGEMLETLLPSFQ 389 Query: 347 SVVDDWYCAPLEGPRGATAEQLLE-----HLGNGKS-----FDSVAQAWDAAMADAKAED 396 +V+ Y + PR E+L+E L G + DS AW A + Sbjct: 390 TVILTQYRS---NPRRIPVEELVELTRAVQLSTGNTSQLSITDSPEAAWLQAKDMLTPDT 446 Query: 397 TVLVCGSFHTVAHVMEVI 414 + V GSF A + E++ Sbjct: 447 LICVTGSFFIAAELRELL 464 >UniRef50_Q67SJ1 Folylpolyglutamate synthase n=1 Tax=Symbiobacterium thermophilum RepID=Q67SJ1_SYMTH Length = 437 Score = 169 bits (427), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 150/421 (35%), Positives = 213/421 (50%), Gaps = 25/421 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKP---APFVFTVAGTNGKGTTCRTLESILMA 73 L+YL L + GLER + +LG +P V + GT+GKG+ +E+ L A Sbjct: 7 LAYLAGLQRFGMKPGLERTVALLEQLG--RPDRRVGRVVHITGTSGKGSVAAMVEAGLRA 64 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPE------SAHTASFAEIESARGDISLTYFEYG 127 AG +VG+Y+SP L+R+ ER++V E+PE +A A AE A G T FE Sbjct: 65 AGRRVGLYTSPPLMRFKERMQVNRAEIPEADVARLTARVAEAAEAVIAAGLEPPTEFEVI 124 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGR 186 T AL F + +D ++LE G+GGR DAT V+ A V +T++ LDHT WLG E+I Sbjct: 125 TAMALAWFAEQSVDDLVLEAGMGGRFDATTAVEKAAVTAITNVGLDHTQWLGQTHEAIAW 184 Query: 187 EKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGA-LLQRRGVEWNYSVTDHDWAFSDAHG 243 +KAG+ R P + G P + I VA+E+GA LL ++ D +D G Sbjct: 185 DKAGVIRPGVPCVTGTDHPGALAVIERVAREQGAPLLHVTPADFRVLGADLSGQVADLRG 244 Query: 244 T---LENLPLPLVPQPNAATALAALRA-SGLEVSENAIRDGIASAILPGRFQIVSES--P 297 + L L+ + AA A ALR L V E AIR+G A PGR +++ + Sbjct: 245 ERGWYRRVRLSLLGRHQAANAAVALRILEVLGVDEGAIREGFAHVAWPGRMELLRAAGGQ 304 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 V+ D AHNP L G + L RV V+GML DKD A LA L + + + Sbjct: 305 LVLLDAAHNPAKCAALAGAVAELFPGRRVHLVVGMLADKDAAQGLAPLLPLAERVWATTP 364 Query: 358 EGPRGATAE---QLLEHLGNGKSFDS-VAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 E PR A QL LG+ + + +A +AA+A A D V++ GSF+TV + Sbjct: 365 ESPRAMPAPELAQLCRELGHPALVAADLPEALEAALAAAAPGDLVVITGSFYTVGPARRI 424 Query: 414 I 414 + Sbjct: 425 L 425 >UniRef50_Q18JB6 Folylpolyglutamate synthase / dihydropteroate synthase n=6 Tax=Halobacteriaceae RepID=Q18JB6_HALWD Length = 836 Score = 169 bits (427), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 137/416 (32%), Positives = 206/416 (49%), Gaps = 36/416 (8%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 L L + LG+E + + A L + +AG+NGKG+T R LE IL AG +VG Sbjct: 10 LTGLQQRRPKLGVETTARMLAHLDNPHASIDCVQIAGSNGKGSTARMLEQILDDAGLRVG 69 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAE-----IESARGDISL-TYFEYGTLSALW 133 +++SP L + E++RV+G+ + + H + + E +E+ R D T+FE T +L Sbjct: 70 LFTSPGLNDFREQIRVEGRTIAKK-HVSKYVERLVPCLETLRADNDEPTHFEALTAVSLA 128 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F +D+ ILEVG+GGR DAT+ VD + VTS++L+HT+ LG + I R+KA + Sbjct: 129 HFAAMDVDIAILEVGIGGRYDATSAVDPIASAVTSVSLEHTELLGETVDVIARDKAQVAP 188 Query: 194 SEKPAIVG-----------EPEMPSTIADVAQEKGALLQRRG----VEWNYSVTDHDWAF 238 SE P I G E ++ + D E + G +E S+ +WA Sbjct: 189 SEAPLITGTTGDALAAIREETDVITVGNDSDSEADIIATETGIPSPIESAVSIVGSEWAV 248 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 +LPL Q A A L +VS + I G+ A PGRF+++S SPR Sbjct: 249 E------THLPLVGAHQATNAGVAATLARQVQDVSIDTIETGLRGATWPGRFELMSHSPR 302 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 V+ D +HNP A L G + + + V + DKD + L S+ + P Sbjct: 303 VVLDGSHNPGATATL-GSLLERYEYDELHVVFAAMQDKDHEAMIQSLPSITTAYATEPAV 361 Query: 359 GPRGATAEQLLEHLG-NGKSFD---SVAQAWDAAM--ADAKAEDTVLVCGSFHTVA 408 R TAE L L N K+ + SV +A + A+ A A+++D VLV GS + VA Sbjct: 362 -ERAETAETLAPILQMNAKTVETIQSVPEATEEAIETAGARSDDLVLVTGSLYAVA 416 >UniRef50_A1HP48 FolC bifunctional protein n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HP48_9FIRM Length = 429 Score = 169 bits (427), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 137/418 (32%), Positives = 206/418 (49%), Gaps = 20/418 (4%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L YL L+ I+LGL R+ + +G + V GTNGKG+T L +IL A+G Sbjct: 7 LEYLATLNKFGINLGLARIKRLLDLMGHPERRYRTVHVTGTNGKGSTTAMLAAILQASGI 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESA------HTASFAEIESARGDISLTYFEYGTLS 130 K G+Y+SPHLV YTER+ V G+ +A +T F E +A G T FE T + Sbjct: 67 KTGMYTSPHLVDYTERMVVDGRPAAPAAFAAAIDYTRRFIEQMTAEGWEHPTEFEVLTAA 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A F +A+++ ++EVGLGG LD+TN++ + AV+T++AL+HTD G I R KAG Sbjct: 127 AFHYFAEAKVEYAVIEVGLGGLLDSTNVISPEAAVITNVALEHTDRCGATVREIARHKAG 186 Query: 191 IFRSEKPAIV-GEPEMPSTIADVAQEKGALLQRRGVEW------NYSVTDHDWAFSDAHG 243 I ++ P I E E + I + A G++L RG ++ Y + G Sbjct: 187 IIKAGVPVITAAEGEALAVIREAAAACGSMLYVRGRDFVGEYLGRYDYGQRVAVHTAQTG 246 Query: 244 TLENLPLPLVPQ---PNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 L L L+ + N A A+ L G ++ +A+ G+A+A PGRF++ P Sbjct: 247 RLGPFSLTLLGRHQVENCAIAVMTALVLAERGAPITPDALAAGLAAARWPGRFEVFPGEP 306 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY-CAP 356 ++ D AHNPH A L + + + ++G+L DKDI G + L D AP Sbjct: 307 VIVVDGAHNPHGARALRVALDEVFGGRPITFLLGILRDKDITGIVRALVRPQDMVVAAAP 366 Query: 357 LEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 L A E E G+ + S+A A A A+ V GS + + V +++ Sbjct: 367 LSERAAAPGEIAREIGGSVEEAPSIAAGLAQARRLAGADGVVCAAGSLYLIGAVRQIL 424 >UniRef50_B5YD69 Folylpolyglutamate synthase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YD69_DICT6 Length = 442 Score = 168 bits (426), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 130/435 (29%), Positives = 204/435 (46%), Gaps = 37/435 (8%) Query: 15 SWLSY---LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 S+++Y L+NL + LER+ + +G + F +AGT GKG+T + SIL Sbjct: 11 SFINYEKRLDNLTYEEKKFYLERMRYLLQLMGNPQDNLQAFHIAGTKGKGSTSAMIFSIL 70 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQ----GQELPESAHTASFAE--IESARGDI---SLT 122 +AGYKVG+Y+SPHL ER+ QE E +A+ IE A+ S T Sbjct: 71 KSAGYKVGLYTSPHLQSIRERIATHEGFISQE--EFVDLIDYAKPYIEEAKKHPIFGSPT 128 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 +FE T A F +LD V++EVGLGGRLDATN+++ ++++T I DH LG E Sbjct: 129 FFEVLTALAFLYFSMKKLDYVVIEVGLGGRLDATNVINPLISIITPIGFDHMHILGDTLE 188 Query: 183 SIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQR-------RGVEWNYSVTD 233 I EKAGI + K I + E I V++E+ A+ + R E N D Sbjct: 189 KIAFEKAGIIKEGKIVISSPQKKEAEEVIERVSRERNAVYYKVDDLFSWRKKEAN---LD 245 Query: 234 HDWAFSDAHGTLENLPLPLVPQP---NAATALAALRA--SGLEVSENAIRDGIASAILPG 288 + E +PL+ + NA TA A+ + L + ++ G + G Sbjct: 246 GQKFLLEGRDIKEEFFIPLLGEHQIVNAVTAYGAIYVLKNRLNIDNEVVKKGFENVQWRG 305 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 RFQI++++P ++ D AHN +A L +++ R+ + G++ DKD L L + Sbjct: 306 RFQIINKNPLIVVDGAHNVDSAMALKNTLESYVNFDRLFLICGIMKDKDAEKFLKILDPL 365 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLGNGKS------FDSVAQAWDAAMADAKAEDTVLVCG 402 V + PL R T E+L + + +D+ + A A D +L+ G Sbjct: 366 VYSYNFIPLPSHRTRTPEELANIVKVFRPNAEINIYDNFSSAISFVNKKASPADLILITG 425 Query: 403 SFHTVAHVMEVIDAR 417 S + ++ R Sbjct: 426 SLYLAGEALDYFYGR 440 >UniRef50_C9L620 Tetrahydrofolate synthase n=1 Tax=Blautia hansenii DSM 20583 RepID=C9L620_RUMHA Length = 432 Score = 168 bits (425), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 128/416 (30%), Positives = 205/416 (49%), Gaps = 28/416 (6%) Query: 30 LGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRY 89 LGLE + + RL + + ++GTNGKGT L +IL AGY+ G Y SP L Y Sbjct: 20 LGLENMKALLDRLDNPQESLKFIHISGTNGKGTVLAYLSTILRKAGYRTGRYISPTLFSY 79 Query: 90 TERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYGTLSALWLFKQAQLDVV 143 ER++V +++ + A I +A D+ + T FE T A FK+ D+V Sbjct: 80 RERIQVNEEKIEKEALAQHVTAIAAAVADMKEKKAGTPTAFEIETALAFLYFKEKNCDIV 139 Query: 144 ILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI--V 200 +LE GLGG LDATNI+ + V+ I++DHTD LG + I +KAGI + + V Sbjct: 140 VLETGLGGALDATNIIQTTQLEVIAPISMDHTDVLGKTLKEIAAQKAGIIKPHTTMVTAV 199 Query: 201 GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF---SDAHGTLENLPLPLVPQ-- 255 E E + V +EK + VE + ++D + + S ++ +N+ + L + Sbjct: 200 QEEEAKEVLQKVCKEKESRFCE--VEKD-EISDIQYGYIRQSFSYKNWKNVEISLAGEFQ 256 Query: 256 -PNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAE 311 N A AL A LR GL + A+ G+ A GRF ++S++P VI D AHNP AAE Sbjct: 257 IQNGALALEAVNQLRKLGLSLPNEAVYAGMKEAKWVGRFTVMSQNPLVILDGAHNPQAAE 316 Query: 312 YLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQLLE 370 L ++ K ++ V G+ DKD + + + + PR AE+L + Sbjct: 317 ALRKSLELYFKGKKLYYVFGVFQDKDYKKIIELTAPLAEHIITVETPDNPRALPAEELKK 376 Query: 371 HL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID--ARRSG 420 + + ++ +S+ A + ++ AED ++V GS + +V+ R++G Sbjct: 377 QVEKINASVETGESIEAAIEKNLSYMGAEDVLVVFGSLSFLGIAAKVLQGGGRKNG 432 >UniRef50_D0LYA5 FolC bifunctional protein n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LYA5_HALO1 Length = 461 Score = 168 bits (425), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 132/353 (37%), Positives = 179/353 (50%), Gaps = 34/353 (9%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFV-FTVAGTNGKGTTCRTLE 68 A+P+ LS L + LGLERV ARLG + V + GTNGKG+T E Sbjct: 12 AAPMQRLLSRLYAARRAGVVLGLERVHACLARLGHPERRMRVRVHIGGTNGKGSTAAFTE 71 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 +I AAG++ G +SSPHL R+ ER + G + + A A+ + +A G+ LT+FE T Sbjct: 72 AIARAAGHRTGRFSSPHLHRFAERFVIDGAAVDDEALIAAGDAVAAAGGE-QLTFFEQTT 130 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 A+WLF + ++V ++EVGLGGRLDATN V A+VA VT +A+DH ++LG +I EK Sbjct: 131 AMAMWLFAERGVEVGVIEVGLGGRLDATNAVSAEVAAVTGVAMDHQEYLGDTLAAIAAEK 190 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 AGIF+ + +VG +R V W + E Sbjct: 191 AGIFKPGQRVVVGRAG----------------EREAVPW-LVEAARAAGAAAVTVVQEPS 233 Query: 249 PLPLV-------PQPNAATALAALRASGL--EVSENAIR--DGIASAILPGRFQIVSESP 297 P L + NAA ALA + + + +N R +A LPGR + V+ P Sbjct: 234 PAALALRLRGPHQRDNAACALAIVEHLAILGHLDDNPARWRQAVAETRLPGRLEQVA--P 291 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 V D AHNPHAA L + ALP+ RVL V+ M DKD AG A L VD Sbjct: 292 EVFVDGAHNPHAARALAASLDALPRP-RVL-VLAMSRDKDQAGIAAALLPAVD 342 >UniRef50_A1ZCQ8 Folylpolyglutamate synthase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZCQ8_9SPHI Length = 428 Score = 168 bits (425), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 124/439 (28%), Positives = 205/439 (46%), Gaps = 54/439 (12%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 Q L L +N+ K + L+ + A LG +AGTNGKG++ L Sbjct: 5 QTLDYLYKQLPIFQNIGGKAFNASLDNIRRFCAHLGNPHTQYPTLHIAGTNGKGSSSHML 64 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 ++L AAGYKVG+Y+SPHL +TERVRV GQ + + A ++ ++FE Sbjct: 65 AAVLQAAGYKVGLYTSPHLKSFTERVRVNGQAIAPAQIVAFVQRYQTQIESWRPSFFEVT 124 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 AL F Q ++DV ++EVGLGGRLDATNIV + ++T+I+ DH LG ++I +E Sbjct: 125 VAMALDYFAQQKVDVAVIEVGLGGRLDATNIVTPEACLITNISFDHQQILGNTLKAIAKE 184 Query: 188 KAGIFRSEKPAIVGEPEMPSTI------------------------ADVAQEKGALLQRR 223 KAGI + P ++GE + +T ADVAQ K ++++ Sbjct: 185 KAGIIKLNTPVVIGERQTETTPVFETTSQQHQAPLYFAQDEYFCKWADVAQGK-LMVKKN 243 Query: 224 GVEWNYSVT---DHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDG 280 G + +T + + +G L+ L + L+ ++++ I +G Sbjct: 244 GKAFLPEITMSLKGSYQEKNINGVLKVLEI--------------LQNRDWQITQEHIIEG 289 Query: 281 IASAI----LPGRFQIVSESPRVIFDVAHNPHA-AEYLTGRMKALPKNGRVLAVIGMLHD 335 + + L GR+Q++ ++P I D AHN ++ +T + + + V+G + D Sbjct: 290 LQKTVELTQLKGRWQVLKKAPLTICDTAHNEAGLSQVMTQLQQLPRQQLHI--VLGAMAD 347 Query: 336 KDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMAD 391 K + L ++CAP PR +L + G ++ SV +A+ A + Sbjct: 348 KVLDKILPLFPMEATYYFCAP-AIPRAMEVNKLKQLAAGFELRGLAYASVMEAYTQAQSQ 406 Query: 392 AKAEDTVLVCGSFHTVAHV 410 A+ D V GS +A + Sbjct: 407 AQINDVVFAGGSTFVLAEI 425 >UniRef50_C7P2D7 FolC bifunctional protein n=4 Tax=Halobacteriaceae RepID=C7P2D7_HALMD Length = 817 Score = 168 bits (425), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 137/422 (32%), Positives = 202/422 (47%), Gaps = 42/422 (9%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 ++L +L + G E + A+LG + +AG+NGKG+T R +E L AG Sbjct: 8 NFLFDLRRFALRPGTEATRSLLAQLGDPHDSLDCVQIAGSNGKGSTARMVERTLREAGLD 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD-----ISLTYFEYGTLSAL 132 VG+Y+SPHL ER+RV G+++ ESA +E D S T FE T A Sbjct: 68 VGLYTSPHLDDVRERIRVNGRKITESAIVEFVESVEPYVTDRAADGTSPTLFETLTALAY 127 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 W F++ +DV ++EVG+GG+LDAT++VD + VT++ L+HTD LG I R+KA + Sbjct: 128 WEFERQSVDVAVIEVGIGGKLDATSVVDPVASAVTTVTLEHTDILGDTVGEIARDKAHVA 187 Query: 193 RSEKPAIVG-EPEMPSTIADVAQEKGALLQ---------------RRGVEWNYSVTDHDW 236 +++P + E + + DVA + + R G+E + S+ +W Sbjct: 188 PADRPLVTATEGDALDAVRDVAGDVVTVADTADGEAGDVSVTDHGREGLEGSVSIAGDEW 247 Query: 237 AFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 G LPL Q A A L +V E I G+ +A PGRF+I+ Sbjct: 248 ------GVETKLPLLGAHQAINAGIAATLCRQVSDVDEATIARGLRNAHWPGRFEIMGRD 301 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKD---IAGTLAWLKSVVDDWY 353 P V+ D AHNP E + + A + + V G + DKD IAG L VV Sbjct: 302 PLVVLDGAHNPGGVERVVETLAAFDYD-ELHVVAGSMVDKDLRAIAGALDGADHVV---A 357 Query: 354 CAPLEGPRGATAEQLL------EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 C P A EQ++ E + ++ VA A+D A+ A +D VLV GS + V Sbjct: 358 CEPDRDR--AEDEQVVAKAFRDETAASVETRSDVAGAFDVALDGAGEDDCVLVTGSLYAV 415 Query: 408 AH 409 A Sbjct: 416 AE 417 >UniRef50_B8I1X5 FolC bifunctional protein n=2 Tax=Clostridium RepID=B8I1X5_CLOCE Length = 424 Score = 167 bits (424), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 115/406 (28%), Positives = 202/406 (49%), Gaps = 31/406 (7%) Query: 30 LGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRY 89 GL+R++ + +G +AGTNGKG+T + SIL+ AGY+ G+++SP++ R+ Sbjct: 20 FGLDRITKLLDLMGNPHKKLKFIHIAGTNGKGSTTAFISSILIEAGYRTGMFTSPYIQRF 79 Query: 90 TERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEYGTLSALWLFKQAQLDVV 143 TER++V E+ ++I++ + G T FE T +++ F + + D+V Sbjct: 80 TERIKVDNNEISNDELAELISQIKNCIEKMVSNGFEHPTEFEIITAASMEYFYKKKCDIV 139 Query: 144 ILEVGLGGRLDATNIVDA-DVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV-- 200 +LEVGLGG +D+TN++D + +VVTSI++DH D LG I +KAGI + + ++ Sbjct: 140 VLEVGLGGIVDSTNVIDTPEASVVTSISMDHMDRLGETLGEIAYQKAGIIKQDGVVVLYP 199 Query: 201 GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA---HGTLENLPLPLV---P 254 E E I V++EK A + + V+++ ++ D ++ S+ + N+ + L+ Sbjct: 200 QEQEAEEVIERVSKEKNAQIHK--VDFS-TIYDKGFSLSEQIFDYKDYRNIKIGLLGDHQ 256 Query: 255 QPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAE 311 NAA A+ L G ++ I DG+ PGR +I++++P V+ D AHN + Sbjct: 257 MRNAAVAIDTCELLCNKGFALTHRNILDGLEKTRWPGRLEIINKNPLVLIDGAHNLEGGQ 316 Query: 312 YLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEH 371 L + + + V+G L DKD G + L + D R + +L E Sbjct: 317 ALNTALDKYFTQKKKIFVVGFLRDKDYIGIMDMLGNKADTIITVTPNNERAVPSAELAEI 376 Query: 372 LGNGKSFD-------SVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 L KS+ S+ A+ A +E + GS + + + Sbjct: 377 L---KSYSNHVVDGMSIENGLQTAVGLADSESVICAFGSLYMIGEI 419 >UniRef50_D1BZM6 FolC bifunctional protein n=10 Tax=Actinomycetales RepID=D1BZM6_XYLCX Length = 468 Score = 167 bits (423), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 120/345 (34%), Positives = 176/345 (51%), Gaps = 23/345 (6%) Query: 28 IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLV 87 ID L+RV V LG + V + GTNGK +T R +ES++ G + G+++SPHL Sbjct: 42 IDPTLDRVRRVLELLGDPQRTYRVVHLTGTNGKTSTARMVESLVREHGLRTGLFTSPHLT 101 Query: 88 RYTERVRVQGQELP---------ESAHTASFAEIESAR-GDISLTYFEYGTLSALWLFKQ 137 TER++V G L + A A+ ESA G L++FE T+ AL F Sbjct: 102 SVTERIQVDGAPLSAARFVEVWEDVAPYIGVADRESAESGGPRLSFFEVLTVMALAAFAD 161 Query: 138 AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKP 197 A +DV ++EVG+GG D+TN+ D DVAVVT + +DH WLG E+I K+GI + Sbjct: 162 APVDVAVIEVGMGGTWDSTNVADGDVAVVTPVGMDHQRWLGDTLEAIASTKSGIVKDGAT 221 Query: 198 AI--VGEPEMPSTIADVAQEKGALLQRRGVEW-----NYSVTDHDWAFSDAHGTLENLPL 250 A+ V EP + + A+ GA L R G E +V G + + Sbjct: 222 AVMSVQEPVVSDVVRARAEAVGAHLLREGYELEVAGRQVAVGGQVVDLRTPAGLYTGVLV 281 Query: 251 PLVPQPNA------ATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 PL + A A+ AL + G + + G A + PGR ++V SP V+ DVA Sbjct: 282 PLHGEHQAHNALLALAAVEALLSGGGALDAGVVEAGFAGVVAPGRVEVVRSSPTVLVDVA 341 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 HNPH A+ L + + + R++ V+G++ DKD G LA L+ V+ Sbjct: 342 HNPHGAQALVDTLDEVFEFTRLVGVVGIMGDKDAEGLLATLEPVL 386 >UniRef50_Q1PZI3 Similar to multifunctional folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZI3_9BACT Length = 464 Score = 167 bits (423), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 129/444 (29%), Positives = 205/444 (46%), Gaps = 32/444 (7%) Query: 1 MIIKRTPQAASPLASWLSY--LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTN 58 + ++ +A + L + L Y L + T L+R+ + ++G + GT Sbjct: 11 LCLRSYEEACAFLNTSLDYEKLISYQYNTSTFNLDRMVRLLEQVGNPHREFSSLHITGTK 70 Query: 59 GKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFA----EIES 114 GKG+T L ++L AGYK G+++SPHL ER+++ ++PE TA+ +I+ Sbjct: 71 GKGSTAIMLSTVLQRAGYKTGLFTSPHLTNLKERIQLNHTKIPEEDFTAALNVLVPDIQR 130 Query: 115 ARGDI---SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIAL 171 R S T+FE T FK+ Q ++ +LEVG+GGRLDATN+V V+V+T+I L Sbjct: 131 LRNTTPAESPTFFETLTAICFLYFKEKQAEMAVLEVGMGGRLDATNVVLPLVSVITNIGL 190 Query: 172 DHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWN- 228 DH + LG I EKAGI + P I +PE S I +V EKGA L G + Sbjct: 191 DHVNILGNTIPRIAYEKAGIIKKGIPVISAAEKPEALSVIKEVCMEKGAPLYLLGKDIRI 250 Query: 229 -----YSVTDHDWAFSDA---HGTLENLPLPLV---PQPNAATALAA---LRASG-LEVS 273 Y+ + + G NL +PL+ N A AL A LR G + + Sbjct: 251 DDAQPYTNKNSRGLLCNIKTWQGVYGNLFIPLMGIHQAKNCAMALGALDVLREHGKISID 310 Query: 274 ENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGML 333 IR+ PGR +++ E+P ++ D AH + L + +++ ++G Sbjct: 311 NETIREAFTHVRCPGRIEVLGETPLIVLDFAHTVESMAALRETLFEHFTFNKLVVILGFS 370 Query: 334 HDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG--NGKSFDSVAQAWDAAMAD 391 DKDI L + +D + R E+L + + GK + A DA +A Sbjct: 371 QDKDIDNILREIVPCANDIFVTKSTNSRAVPPEELAKKIKAVYGKRAEICNSARDAVIAA 430 Query: 392 AKA---EDTVLVCGSFHTVAHVME 412 A +D + + GS + V + Sbjct: 431 QHAASPDDLLCITGSAYIAGEVRQ 454 >UniRef50_C2E893 Folylpolyglutamate synthase / dihydrofolate synthase n=1 Tax=Lactobacillus ruminis ATCC 25644 RepID=C2E893_9LACO Length = 437 Score = 167 bits (423), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 120/427 (28%), Positives = 209/427 (48%), Gaps = 29/427 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 +S++ T D L ++ +A +G + + V GTNGKG+ L +LM+ GY Sbjct: 10 VSFIHGRRKFTKDPSLVKMRRMAELMGNPQKKLKLIHVTGTNGKGSVTAYLRELLMSHGY 69 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTY-----FEYGTLSA 131 +VG ++SP +VR+ ERV + G+ +P++ I+ I + E+ L+A Sbjct: 70 RVGTFTSPFIVRFNERVAINGEMIPDNELVEEVERIKPVIERIDDEFDNDGPKEFEVLTA 129 Query: 132 LWL--FKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 + L F + ++D I+EVG+GG D+TNI+D V+V+T++A+DH + LG + KA Sbjct: 130 IMLDYFVKMEVDYAIIEVGIGGTYDSTNIIDPIVSVITTVAMDHANILGDTIAKVAENKA 189 Query: 190 GIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSV---TDHDWAFSDAHGT 244 GI + ++P I+G+ E I A+E+ + + + V++ + DH W S A+ Sbjct: 190 GIIKKKRPVIIGKLPKEALEVILSKAKEQDSRIYQPEVDYRARLEEGCDHFWGESFAY-E 248 Query: 245 LENLPLPL--------VPQPNAATALAALRA----SGLEVSENAIRDGIASAILPGRFQI 292 E PL NAA AL A G+++ + + PGRF+ Sbjct: 249 FEEEKWPLQRTGLFGNFQVDNAACALTAFNVLSEIEGIKIDRRKAGEALEKTRWPGRFEK 308 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTL-AWLKSVVDD 351 + E P ++ D AHNP A E + ++ K ++ ++G+L DK+ + LK+ Sbjct: 309 IQEDPLIVLDGAHNPSAMEEVEKTLETNFKGKKITVILGILADKNSGEMIEVLLKNPKAS 368 Query: 352 WYCAPLEGPRG-ATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 +GPR A+ ++L E+ D +A +AA+ + D +L GS + ++ V Sbjct: 369 IILTGFDGPRQVASPKKLHENHPRTIEIDDWKEALEAAL--MQKSDLILASGSLYFISDV 426 Query: 411 MEVIDAR 417 + I R Sbjct: 427 RKYILER 433 >UniRef50_D2R4J4 FolC bifunctional protein n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R4J4_9PLAN Length = 465 Score = 167 bits (423), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 137/401 (34%), Positives = 184/401 (45%), Gaps = 57/401 (14%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 + GT GKG+T + SILMA+GYKVG+Y+SPHL ER V GQ++ EI Sbjct: 60 ITGTKGKGSTSLMMASILMASGYKVGLYTSPHLEHLEERFVVDGQQISSEVLVELVREIR 119 Query: 114 SA----------RGDIS--LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDA 161 SA RGD+ T+FE T A+ F + ++D+ +LEVGLGGRLD+TN+ Sbjct: 120 SAVDQLDAEAEARGDLEGGPTFFEVTTAMAMLHFAREKVDIAVLEVGLGGRLDSTNVCHP 179 Query: 162 DVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG----EPEMPSTIADVAQEKG 217 +TSI+ DH LG ++I REKAGI + P I G EP I +A E+ Sbjct: 180 IATAITSISFDHMRQLGNTLDAIAREKAGIIKPGVPMICGVLANEPR--EAIEAIASEQR 237 Query: 218 ALLQRRGVEWNY------------------SVTDHDWAFSDAHGTLENLPLPLVPQ-PNA 258 A L + G E+ S + W +D L +P Q N Sbjct: 238 APLVQLGKEFEAIDLGASPSGGQLMHYREPSGREGAWELNDV-----ELAMPGAHQVRNG 292 Query: 259 ATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTG 315 A A+A L G +S IR G+ASA R + V+ P VI DVAHN + E L Sbjct: 293 AIAIAICHQLVQQGYRISPATIRQGLASARAQARIERVNIRPAVILDVAHNVASIEALAD 352 Query: 316 RMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD-WYCAPLEGPRGATAEQLLEH--- 371 + + R + ++ DK+ + L L + D L PR QLLE Sbjct: 353 VISQQFSSHRKILILASSRDKETSAMLGALLPLFDHVILTCYLLNPRAVEPPQLLEMARR 412 Query: 372 -LGNGK-------SFDSVAQAWDAAMADAKAEDTVLVCGSF 404 L K + DS A A+ AM A ED V + GSF Sbjct: 413 VLSESKLPEPMLETADSPASAYARAMELAGGEDLVCITGSF 453 >UniRef50_B6JCP5 FolC bifunctional protein n=17 Tax=Alphaproteobacteria RepID=B6JCP5_OLICO Length = 442 Score = 166 bits (421), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 127/364 (34%), Positives = 174/364 (47%), Gaps = 19/364 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLG-VLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L L+ L LH K IDL L R+ + L + P V VAGTNGKG+T L +I Sbjct: 11 LDDLLARLAALHPKRIDLDLSRMHRILEALDHPERRLPPVIHVAGTNGKGSTVAFLRAIC 70 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 AAG +V VY+SPHLVR ER R+ G+ ++ +FA E A G +T FE T +A Sbjct: 71 EAAGLRVHVYTSPHLVRLNERFRIAGELASDAQLEDAFARCERANGGAPITLFEIETAAA 130 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIGREKAG 190 LF Q DV++LEVGLGGRLDATN+V+ +A V+T + LDH ++LG I EKAG Sbjct: 131 FLLFSQHIADVLLLEVGLGGRLDATNVVETPLASVITPVGLDHFEFLGDTLIKIATEKAG 190 Query: 191 IFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 I + P IV E E + I A++ A L EW+ V + D G L+ Sbjct: 191 IIKRNVPVIVAEQQAEAQAVIEQTARKMRAPLFCATQEWHVGVEHGRLVYHDERGLLDVT 250 Query: 249 PLPLVPQ---PNAATALAALRA-SGLEVSENAIRDGIASAILPGRFQ---------IVSE 295 L + NA A+A LRA L + A G+ SA P R Q + + Sbjct: 251 APRLFGRHQFDNAGLAIATLRAIPSLAIEPAAFEQGVVSAQWPARMQRLPAGTLATLAPQ 310 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGR--VLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 + D HN + L + V+ ++GM+ +KD LA + Sbjct: 311 GCELWLDGGHNADGGRVAAAALADLGERVERPVVLIVGMMGNKDARAFLANFSGLTRHVL 370 Query: 354 CAPL 357 P+ Sbjct: 371 AVPI 374 >UniRef50_Q38XD0 Putative polylpolyglutamate synthase n=1 Tax=Lactobacillus sakei subsp. sakei 23K RepID=Q38XD0_LACSS Length = 434 Score = 166 bits (420), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 120/409 (29%), Positives = 198/409 (48%), Gaps = 35/409 (8%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 L R++ + A LG V GTNGKG+ + S+L+ G KVG Y+SP + R+ Sbjct: 24 NLNRMTQLLAALGNPHQGQQFIHVTGTNGKGSVVNMVSSLLVELGLKVGRYTSPFITRFN 83 Query: 91 ERVRVQGQELPE------SAHTASFAE-IESARGDISLTYFEYGTLSALWLFKQAQLDVV 143 ER+ + Q + + + H E ++ A +T FE T FKQ +D+ Sbjct: 84 ERIAIDQQPIADDDLVAVTQHVQQTIETVQQADTTFEVTEFELITAIMFTYFKQQAVDIA 143 Query: 144 ILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE- 202 ++EVG+GG D+TN++ ++V+TS+ LDH LG +I +KAGI +++ P ++G+ Sbjct: 144 VIEVGIGGLYDSTNVLTPLISVITSVGLDHQALLGDTLAAIATQKAGIIKAQHPVVIGKL 203 Query: 203 -PEMPSTIADVAQEKGALLQRRGVEWNYSVTD------HDWAFSDAHGTLENLPLPLVPQ 255 E + I + A+ + L GV+++ + F + TL+ L +PL+ Sbjct: 204 PAEAQTVIVETAKRLASPLAISGVDFSTTAVKTLPTWGQQLNFQNQTVTLKQLQIPLMGD 263 Query: 256 ---PNAATALA------ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 NAA AL AL L++ ++ G+A PGRF+ V++ P +I D AHN Sbjct: 264 YQIENAAVALETFCQYLALTQQPLDI--KTLKRGLAHVSWPGRFEKVNDEPLIILDGAHN 321 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATA 365 P E L K K+ + + G L DK +AG L L + + + PR AT Sbjct: 322 PAGVEQLVKTAKHQFKHQDIYILFGALGDKSLAGMLPELNQLATHLVLTTVPDNPRAATQ 381 Query: 366 EQLLEHLGNGKSFDSVAQAWDAAM----ADAKAEDTVLVCGSFHTVAHV 410 Q + N F++ W A+ ++ A+D +LV GS + ++ + Sbjct: 382 AQ-YAAVDNTIPFEA---DWPVALTTMVSELSADDVLLVTGSLYLISTI 426 >UniRef50_D0WR93 Tetrahydrofolate synthase n=2 Tax=Actinomycetales RepID=D0WR93_9ACTO Length = 571 Score = 166 bits (420), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 133/431 (30%), Positives = 201/431 (46%), Gaps = 38/431 (8%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 A + S L + LERV A LG + A + GTNGK +T R +E++L Sbjct: 129 AVYRSILTRAPEHKVQPSLERVRKALAMLGNPERAFRSIHITGTNGKTSTARMIEALLRE 188 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE----------SARGDISLTY 123 G + G ++SPHL ER+ + G + A + E+ +A G +++ Sbjct: 189 RGLRTGRFTSPHLTSVRERMAIDGAAISREDFLAVWEEVNPVVELVDRESTAAGGPRMSF 248 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T+ A F A +DV ++EVG+GG DATN+++ADVAV+ +A+DH WLG E Sbjct: 249 FEVFTVMAYAAFANAPVDVAVVEVGMGGLWDATNVIEADVAVILPVAMDHERWLGHTIEE 308 Query: 184 IGREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRG-----VEWNYSVTDHDW 236 I REK GI + + E E + + D +E A L G V +V Sbjct: 309 IAREKVGIVKPGSFVVSAEQEDSVAQIVMDATREAKARLVAEGPSLHLVSRETAVGGQLV 368 Query: 237 AFSDAHGTLENLPLPLVPQPN-----AATALAALRASGLEVSENAIRDGIASAILPGRFQ 291 E++PL L + A A A G + + + S PGR + Sbjct: 369 TLQTPAARYEDVPLALKGEHQARNAAIALAAAEAFFGGGAFAADVVEHAFMSVSSPGRLE 428 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKA-LPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 IV SP V+ D AHNPH A+ ++ P GR++ V+GM+ DKD+ G L L+ V+D Sbjct: 429 IVRSSPTVVVDAAHNPHGAQATADALREYFP--GRLVGVVGMMADKDVEGFLGVLEPVLD 486 Query: 351 DWYCAPLEGPRGATAEQLLE----HLGNGKSF--DSVAQAWDAAMADAKAED-------T 397 + R A++L + G+G+ F ++A+A D A A+++D Sbjct: 487 AVVVTDIASDRAMDADELADIAGGVFGDGRVFVERNLAEAIDRAAGLAESDDGAPMASPA 546 Query: 398 VLVCGSFHTVA 408 V+V GS VA Sbjct: 547 VVVLGSIQLVA 557 >UniRef50_C6J218 Bifunctional protein folC n=1 Tax=Paenibacillus sp. oral taxon 786 str. D14 RepID=C6J218_9BACL Length = 462 Score = 166 bits (419), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 126/440 (28%), Positives = 204/440 (46%), Gaps = 34/440 (7%) Query: 5 RTPQAASPLASW---LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 RT + PL S+ + ++ L I GLER+ L+ +LG + VAGTNGKG Sbjct: 9 RTEEETRPLNSYAEAVDWINGLLPFGIRPGLERIELMMEKLGHPERRLKFIHVAGTNGKG 68 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-- 119 ++C L L GY VG Y+SP++ ++T R + +++PE+ + +I Sbjct: 69 SSCAFLTRTLRECGYHVGTYTSPYITKFTNRFQYDEEDIPETVLLELANRVAPLVAEIAG 128 Query: 120 ----SLTYFEYGTLSALWLFKQAQL-DVVILEVGLGGRLDATNIVDADVAVVTSIALDHT 174 S T FE T A+ F + DVV+ E GLGGR+D TNIV V+++T+I LDH Sbjct: 129 TELGSPTMFEVSTAIAILYFAEVCYPDVVVWETGLGGRMDVTNIVTPIVSLITNIGLDHM 188 Query: 175 DWLGPDRESIGREKAGIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT 232 D LG E I REKAGI ++ P + +PE + + + A K A L G ++ Y Sbjct: 189 DVLGDTIEQIAREKAGIIKAGVPVVSCAEQPEAVAVLKETAAAKHATLYLMGEQFRYERV 248 Query: 233 DHDWAFSDAH--GTLENLPLPLV-----PQPNAATALAAL----RASGLEVSENAIRDGI 281 D H G + + NAA + L + + + ++DG Sbjct: 249 AVDAKEQQLHFQGPFREMDFTIRMLGEHQCKNAAGVMMVLEVLRQYMAFILEDEQVQDGF 308 Query: 282 ASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGT 341 ++ GR ++V E PR++ D AHNP A L + + ++ ++GML +K G Sbjct: 309 RTSFWAGRLEVVREEPRLVLDGAHNPEGAASLAKSLPEAFQYRKLHLMMGMLANKHHQGY 368 Query: 342 LAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDS-------VAQAWDAAM----A 390 L + +VD + R A+ L E + + ++ V + W A+ + Sbjct: 369 LKHILPIVDTLILTEPDFRRKMDADALYELVAELQGIEAKADLEIIVERDWRKALSLLES 428 Query: 391 DAKAEDTVLVCGSFHTVAHV 410 + ED +V G+ + ++ V Sbjct: 429 RTEREDLGVVTGTLYLISDV 448 >UniRef50_UPI00016C3FCF FolC bifunctional protein n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C3FCF Length = 437 Score = 166 bits (419), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 135/419 (32%), Positives = 197/419 (47%), Gaps = 29/419 (6%) Query: 13 LASWLSYL--ENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 LA W + E + +DL LER+ + RLG + + V GT GKG+TC LES+ Sbjct: 7 LAFWYGRINYEVRSAGPLDLKLERMRALLRRLGDPQDRLRLVHVTGTKGKGSTCAMLESV 66 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-------SLTY 123 L AGY+ G+++SPHL ER++V + A E+ A + S T+ Sbjct: 67 LRTAGYRAGLFTSPHLAHIEERMQVDRVPISHGELAACMEEVAPAVRAMETDPRFPSPTF 126 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE GT F + + D+ ++EVGLGGR D+TN+ V+V+T++ DH LG E+ Sbjct: 127 FEIGTALGFLHFVRRRCDIALIEVGLGGRFDSTNVCQPLVSVITNVGPDHMAQLGTTLEA 186 Query: 184 IGREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNY---SVTDHDWAF 238 I +KAGI + P + G + + I VA E A + GV+ S + Sbjct: 187 IAFQKAGIIKRRVPVVSGVTQDGPRAVIRQVAAELSAPIWEVGVKPCSPIPSFKREELHV 246 Query: 239 SDAHGTLENLPLPLV---PQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQI 292 ++ G + P+ L+ + NAA A A LR +G+ + A+ G+ P R ++ Sbjct: 247 AEEVG-VRAAPIGLLGAHQRANAAVATAVLDRLRTAGMHIPAAAVARGLGEVKWPARVEV 305 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMK-ALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 V E P I D AHN +AE L ++ A P G V + DK A L L S D Sbjct: 306 VRERPTTILDTAHNVPSAEALVTTLREAFPNAGTKRVVFAVSSDKQFAEILRVLASYFDH 365 Query: 352 WYCAPL-EGPRGATAEQLLEHLGN---GKSFD---SVAQAWDAAMADAKAEDTVLVCGS 403 +Y PRG E L L GK F + +AW+AA++ D V V GS Sbjct: 366 FYFTKYSNNPRGVPTEALATALAAVAPGKPFTLHATAPKAWNAAVSTVTDTDLVCVTGS 424 >UniRef50_C0GEY6 FolC bifunctional protein n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GEY6_9FIRM Length = 431 Score = 165 bits (418), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 127/420 (30%), Positives = 208/420 (49%), Gaps = 22/420 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + ++ +L+ I+ GLER++ + RL + +AGTNGKG+T L S+L A G Sbjct: 7 IDWIHSLYRFGINPGLERITELLRRLEDPQKKIRCIHIAGTNGKGSTAAFLASMLEAQGL 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTY------FEYGTLS 130 +VG+Y+SP+L +T R+ + G ++ E+ +I +IS T FE T Sbjct: 67 QVGLYTSPYLEAFTNRMAINGGDIDENRLAELVTQIRRHVEEISQTEAGQPTEFEVVTAL 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A F + Q D VI+EVGLGGRLDATN+++ V+V+T+I L+HT LG +I EKAG Sbjct: 127 AFLYFAEEQPDWVIMEVGLGGRLDATNVIEPAVSVLTNIGLEHTQVLGDTISAIAFEKAG 186 Query: 191 IFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY-----SVTDHDWAFSDAHG 243 I + PA+ + + VA E+GA L ++ Y S+ + + Sbjct: 187 IIKPSTPAVTAAEKEDALQVFRSVAVERGATLVEMDRDFGYEQLSASLDGQVFNYWSRQR 246 Query: 244 TLENLPLPLV-PQP--NAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 L+NL + L+ P NAA A+A + + +AI G+A+A PGR ++ S P V+ Sbjct: 247 KLDNLQISLLGPHQVRNAALAVATRELLPVPLDTDAIYRGLAAAKWPGRLEVFSRRPLVL 306 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD-DWYCAPLEG 359 D AHN + L + + + V+G+L DK + L+ + + + Sbjct: 307 VDGAHNIDGIKALKSALDTILDGRPLRLVLGILGDKAVDEILSLIVPLATAGLIVTKPDN 366 Query: 360 PRGATAEQLLEHLGNGKS-----FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 PR + ++ E S D+V +A +A E+ + + GS +T++ EV+ Sbjct: 367 PRASNPREVAELARRYTSAPVAATDTVEEAVALGLAQTGEEEALCISGSLYTISEAREVL 426 >UniRef50_Q5SLF0 Folyl-polyglutamate synthetase n=6 Tax=Deinococci RepID=Q5SLF0_THET8 Length = 414 Score = 164 bits (416), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 142/404 (35%), Positives = 198/404 (49%), Gaps = 34/404 (8%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GLER+ ARLG + A V V GTNGKGTT R L +IL AG++VG+Y+SPHLV + Sbjct: 17 GLERIRAFLARLGHPEEAYPVALVGGTNGKGTTARALAAILEEAGFRVGLYTSPHLVDFR 76 Query: 91 ERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLG 150 ER++VQG+ +PE A AE+ + ++FE T AL F + ++ +LEVGLG Sbjct: 77 ERIQVQGRPIPEEKLLALLAELRPHAERLEASFFEVATALALLHFAREGVEFAVLEVGLG 136 Query: 151 GRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIA 210 GRLDATN + ++VVT++ DH + LGP + + REKAGIFR PA+ + Sbjct: 137 GRLDATNATEPVLSVVTNVGHDHLEVLGPTLKDVAREKAGIFRGGVPALTA-----ARGE 191 Query: 211 DVAQEKGALLQRRGVEWNYSVTDH---------DWAFS-DAHGTLENLPLP---LVPQPN 257 + + L R+ W H AF+ T E L L L P Sbjct: 192 GLGVLRAEALARKTPLWVLGEDFHAEGVEALPQGLAFTLRLERTGEALRLTARLLGPHQA 251 Query: 258 AATALAALRASGLEVSENAIRDGIASAILPGRFQ-IVSESPRVIFDVAHNPHAAEYLTGR 316 ALAAL L A++ G+A A PGR Q ++ ++ D AHNP A L Sbjct: 252 ENLALAALSGRLLGAGWEAVKRGVARAENPGRLQRLLWRGRELLLDGAHNPEGALALR-- 309 Query: 317 MKALPKNGRVLA--VIGMLHDKD---IAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEH 371 +AL +G + A V+G DKD +A L L VV Y + PR LL Sbjct: 310 -EALRFHGLLPAAFVLGFSRDKDHAAMAEALRGLGPVVLTRYAS----PRSEDPRALLPL 364 Query: 372 LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 K + +A + A + E V+V GS + V V+ ++ Sbjct: 365 FPGAKVVEDPLEALEEAFSR---EGRVVVAGSLYLVGEVLRRLE 405 >UniRef50_D0JAL7 Bifunctional folylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Blattabacterium RepID=D0JAL7_BLASB Length = 415 Score = 164 bits (416), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 107/403 (26%), Positives = 195/403 (48%), Gaps = 41/403 (10%) Query: 31 GLERVSLVAARLGVLKPAPFV--FTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVR 88 GL+R+ + LG P F V GTNGKG+T L SIL YK+G+++SPHL+ Sbjct: 28 GLKRILNFCSHLG--NPQNFFKSIHVGGTNGKGSTVHMLSSILQEEKYKIGLFTSPHLID 85 Query: 89 YTERVRVQGQELPESAHTASFAE-----IESARGDISLTYFEYGTLSALWLFKQAQLDVV 143 + ER+ G L E F IE+ + +++FE T A FK+ Q+++ Sbjct: 86 FRERITCNGV-LIEKDFVVDFIRKNQKFIENEK----ISFFEMNTALAFQYFKERQVNIA 140 Query: 144 ILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEP 203 I+EVGLGGRLD+TN++ +++V+T++++DHT+ LG + I EKAGI + I+G Sbjct: 141 IIEVGLGGRLDSTNLIIPEISVITNVSIDHTETLGNSKLKIAFEKAGIIKKNVSVIIGRK 200 Query: 204 EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQP-NAATAL 262 +++E + + ++ N + ++ + +P Q N + L Sbjct: 201 --------ISKEIQFIFFKEALKKNSPIY---FSVKEKEDFKYKMPFEADYQDLNRSVVL 249 Query: 263 AALRA----SGLEVSENAIRDGIASAI----LPGRFQIVSESPRVIFDVAHNPHAAEYLT 314 + + VS +I+ G+ + I GR+QI+ P+++ D+AHN + + Sbjct: 250 KTVNILHYRKNIIVSNQSIKKGLKNVIKNTNFKGRWQILQNKPKIVCDIAHNEEGIDMIN 309 Query: 315 GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR------GATAEQL 368 ++K N ++ V+G + +K++ L + ++C P + ++ Sbjct: 310 HQLKKESYN-KLHLVLGFVKEKEVEKLLKYFPIESFYYFCQPKIDRKFPIDDLKILVHKM 368 Query: 369 LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 ++ + SV +A+ +A A D +L+ GS V+ V+ Sbjct: 369 FKNRSKISFYSSVEKAFLSAKERADKNDLILISGSTFIVSEVL 411 >UniRef50_B1YJU6 FolC bifunctional protein n=2 Tax=Exiguobacterium RepID=B1YJU6_EXIS2 Length = 416 Score = 164 bits (416), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 132/416 (31%), Positives = 207/416 (49%), Gaps = 30/416 (7%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L +L L + I GL R+ + A L + A VAGTNGKG+T L + +A G Sbjct: 8 LEWLSALLAFGIKPGLSRMEALLAELMIDPDAIPTIHVAGTNGKGSTVAFLREMGVAEGL 67 Query: 77 KVGVYSSPHLVRYTERVRVQG-----QELPESAHT--ASFAEIESARGDISLTYFEYGTL 129 +VG ++SP+++++ ER+ + G +L E+A+ A+ ++E G +LT FE T+ Sbjct: 68 QVGTFTSPYIIQFEERIMLNGVPISEADLVEAANVVQAAILKLEPVIG--ALTEFEALTV 125 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDA-DVAVVTSIALDHTDWLGPDRESIGREK 188 A + F Q + D VI EVGLGG D+TN++ A++TSI DH LG + I +K Sbjct: 126 LAFYHFYQIRPDFVIYEVGLGGLYDSTNVLKQPKAAIITSIGHDHQAILGDTLQEIALQK 185 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT-DHDWAFSDAHGTLEN 247 GI + I G+ + T+ +A ++ + W+ V D+ + + T E Sbjct: 186 FGIIKQGTRVIAGKLQEELTVPLMAYCGD---RQASLSWSQEVIRDYRLSATGTWATYEG 242 Query: 248 LP-----LPLVPQ-PNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 +P L + Q NAA A+ + G S+ AIR G+ +A PGRF+I+S PR+I Sbjct: 243 IPETRLGLEGMHQVHNAANAVVCAKQLGW--SKTAIRRGLRNATHPGRFEIISRKPRIIL 300 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D AHNP L R+K K V+ + +L DKD L L+ V D Y + PR Sbjct: 301 DGAHNPEGVTALVERLKEESKP--VVVLCSILRDKDRKAMLRQLREVTPDIYETTFDFPR 358 Query: 362 GATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 T E+L +S + D A+ T++V GS + ++ V ++ A+ Sbjct: 359 ARTLEELEMDGAKAMELNSFFKEVDT------ADKTLIVTGSLYFISTVRTLLKAQ 408 >UniRef50_Q9K8G9 Folyl-polyglutamate synthetase n=1 Tax=Bacillus halodurans RepID=Q9K8G9_BACHD Length = 430 Score = 164 bits (415), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 129/407 (31%), Positives = 194/407 (47%), Gaps = 26/407 (6%) Query: 28 IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLV 87 I GL+R+ + +LG + V + GTNGKG+T + +L AGY VG ++SP++ Sbjct: 19 IKPGLQRIEWMLEKLGHPEKELNVVHIGGTNGKGSTVSFMRCMLTEAGYNVGTFTSPYIE 78 Query: 88 RYTERVRVQGQELPESAHTASFAEI-----ESARGDI-SLTYFEYGTLSALWLFKQAQLD 141 + ER+ +G+ + S I E R D+ S T FE T+ A F + D Sbjct: 79 HFRERIAYKGEPISSEELVRSCLNIIDVVEELKRTDLGSPTEFEVITVIAFDFFARVNPD 138 Query: 142 VVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI-- 199 +V+LEVGLGGRLD+TNIV ++++TSI DH + LG ESI EKAGI + + PAI Sbjct: 139 IVLLEVGLGGRLDSTNIVTPLLSIITSIGHDHMNVLGGTLESIAYEKAGIIKPDIPAIVH 198 Query: 200 VGEPEMPSTIADVAQEKGALLQRRGVEWN---YSVTDHDWAFSDAHGTLENLPLPLVPQ- 255 V +PE I D A + A L G +++ SVT FS + L L V + Sbjct: 199 VKQPEAFRVIQDKANKVKAPLFAYGTDFHSLPKSVTMDKQFFSYQSQSGLTLSLETVMKG 258 Query: 256 ----PNAATALAALRA----SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNP 307 NA+ A+ A+ E+S + I GI + GRF+ +SE+P D AHN Sbjct: 259 HHQIENASMAIQAIEQLRSMKHYELSNDHIVRGIRNTTWIGRFEKISEAPLTFVDGAHNE 318 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQ 367 + L + + V+ + +K++ LA + + E R AEQ Sbjct: 319 EGMKALAELLALHFPTYKYRFVMAVTKEKEMKALLAPYVDLPASFTFTTFEFERAQKAEQ 378 Query: 368 LLEHLGNGKSFDSVAQAWDAAM----ADAKAEDTVLVCGSFHTVAHV 410 L E S+ W A+ KA + V++CGS + ++ V Sbjct: 379 LYEQAPVYNK--SICADWKVAIRRERESCKANEMVIICGSLYFISKV 423 >UniRef50_A3ZWP1 Folyl-polyglutamate synthetase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZWP1_9PLAN Length = 470 Score = 164 bits (414), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 138/403 (34%), Positives = 198/403 (49%), Gaps = 31/403 (7%) Query: 32 LERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTE 91 L R+ + LG L + +AGT GKG+T TL +IL A GY+VG++SSPHL R E Sbjct: 50 LARMRRLDQLLGNLVDQLKIVHIAGTKGKGSTATTLSAILEADGYQVGLFSSPHLERLEE 109 Query: 92 RVRVQ-----GQELPESAHTAS--FAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVI 144 R + E+ + H + +I++ R TYFE T AL F + +D I Sbjct: 110 RFAINRIACSADEVTQLIHDIAPVVLQIDAERDGDGPTYFEITTAMALMHFVRKGVDAAI 169 Query: 145 LEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--E 202 LEVGLGGRLD+TNI V+V+T+I+ DH LG I EKAG+ ++E P I G + Sbjct: 170 LEVGLGGRLDSTNICRPLVSVITTISRDHMALLGDTLAEIAAEKAGVIKTETPIISGVDQ 229 Query: 203 PEMPSTIADVAQEKGALLQRRGVEW-----NYSVTDHDWAFSDAHGTLENLPLPLVPQ-- 255 P+ + I +A + A L G ++ D W + TL L + + Sbjct: 230 PDPTAVIEQIAAQHAAQLIEVGRDFVVQSHGERTFDLTWRQGEKSETLTGLMCRMAGKHQ 289 Query: 256 -PNAATAL---AALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAE 311 NAA A+ +L++ G VSE AIR G++ A LPGR + +++SP + D AHN + Sbjct: 290 MRNAALAVMVAKSLQSYGFTVSEAAIRRGVSDAELPGRIERLADSPVIYVDAAHNDASIT 349 Query: 312 YLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD-WYCAPLEGPRG---ATAEQ 367 L + LP N R L V+ + DK+ L L D+ W+ PR A E Sbjct: 350 ALLDVLNELPVNRRRL-VLALSSDKEHREILKLLLPHFDEIWFTRYATNPRAVEPAELEA 408 Query: 368 LLEHLGNGKS------FDSVAQAWDAAMADAKAEDTVLVCGSF 404 L L G+ + QA+ AA+A + D + V GSF Sbjct: 409 LAVKLPTGRRTVIRHIVEDPQQAFAAAIAASDENDLLCVAGSF 451 >UniRef50_C6W460 FolC bifunctional protein n=7 Tax=Bacteroidetes RepID=C6W460_DYAFD Length = 433 Score = 163 bits (412), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 129/425 (30%), Positives = 202/425 (47%), Gaps = 31/425 (7%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L L +N+ ++ GL + LG + +AGTNGKG+T L +IL Sbjct: 10 LYDRLPVFQNIGARAFKPGLHTTRELCKLLGDPQDQFPTIHIAGTNGKGSTSHMLAAILQ 69 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AGY+VG+Y+SPHL + ER+RV G + E + +S +S ++FE A Sbjct: 70 EAGYRVGLYTSPHLKDFRERIRVNGVPVSEDFIVDFIDDQKSNIERLSPSFFEVTVAMAF 129 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F ++++DV ++EVG+GGRLD+TN++ +++V+T+I+ DH +LG I EKAGI Sbjct: 130 SYFGRSKVDVAVIEVGMGGRLDSTNVITPELSVITNISFDHMQFLGDTLGKIAAEKAGII 189 Query: 193 RSEKPAIVGE---PEMPSTIADVAQEKGALLQ--RRGVEWNYS--------VTDHDWAFS 239 ++ P +V E E+ I A+ A L R + Y V + Sbjct: 190 KNAVPVVVSEDQNAEISDVITAAAENAQAPLTFAARAYDVTYVGMRDGLMLVNIQNRGSG 249 Query: 240 DAHGTLENLPLPLVPQ---PNAA---TALAALRASGLEVSENAIRDGIAS----AILPGR 289 D ENL L L N A A AL + G + + A+ + + L GR Sbjct: 250 DLEA--ENLALDLTGSYQLKNVAGVWAARKALLSKGWNICDEAVIRALRAVGSITGLKGR 307 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 +Q + ++P V D AHN + +++ K G+ VIG + DKDI+ L+ Sbjct: 308 WQQLGQAPNVYCDTAHNTAGLTATLAQFESVCK-GKKRFVIGFVGDKDISTMLSLFPRDA 366 Query: 350 DDWYCAPLEGPRGATAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 ++C P R A +L LE G++F +V +A AA+ D+ D + V GS Sbjct: 367 QYYFCEP-SNMRALKAPELQARALECGLAGETFGNVKEALAAALRDSAPTDAIYVGGSTF 425 Query: 406 TVAHV 410 VA + Sbjct: 426 VVADI 430 >UniRef50_B7L3L1 FolC bifunctional protein n=2 Tax=Methylobacterium chloromethanicum RepID=B7L3L1_METC4 Length = 467 Score = 163 bits (412), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 139/438 (31%), Positives = 203/438 (46%), Gaps = 38/438 (8%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLG----VLKPAPFVFTVAGTNGKGTTC 64 A + + L LH++ ID L R+ + A LG VL P V VAGTNGKG+ Sbjct: 22 AGTGVERLLEQCSRLHTQEIDYSLHRMHRLLADLGSPERVLPP---VIHVAGTNGKGSAI 78 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESA-----HTASFAEIESARGDI 119 + ++L A G +V Y+SPHLV + ER+R+ A +E RG Sbjct: 79 AVMRTLLEAGGLRVHTYTSPHLVHFNERIRLASINASRPVADDVLENALMYCLECNRGR- 137 Query: 120 SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLG 178 +T FE T +A +F DVV+LE GLGGR DATN+V VA V+TSI+ DH +LG Sbjct: 138 PITQFEVVTAAAFHMFATHDADVVLLEAGLGGRCDATNVVPKPVATVITSISYDHETYLG 197 Query: 179 PDRESIGREKAGIFRSEKPAIVGEPEM---PSTIADVAQEKGALLQRRGVEWNYSVTDHD 235 E I EKAGIFR P IVG + + I+ A GA + + G ++ V Sbjct: 198 SSIEQIAVEKAGIFRPGIPVIVGPQQYFVAENVISRAASLIGAPIHKAGRDFRGKVRGDK 257 Query: 236 WAFSDAHGTLENLPLPLVPQP----NAATALAALRASGLEVSENAIRDGIASAILPGRFQ 291 + + D+ G L + PLP + N++TA+A L +GL +R + PGR Q Sbjct: 258 FVYIDSEG-LHSWPLPGLAGEHQIDNSSTAIATLLTTGLMPDSATVRRALPLVRWPGRLQ 316 Query: 292 --------IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGR--VLAVIGMLHDKDIAGT 341 ++ V+ D HNP AA + ++ + + + ++GML KD A Sbjct: 317 PLTGRVAEMLPPDTDVVVDGGHNPGAAAVIASELRRRNETDQRSTVLILGMLATKDAAAF 376 Query: 342 LAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG-----NGKSFDSVAQAW-DAAMADAKAE 395 LA V PL + Q L + +G + SV +A +A + + Sbjct: 377 LAPFLGSVFRVVTVPLRPDLISHDPQTLAAIAGDIGLSGHAASSVTEAIAEAGRLTSTLK 436 Query: 396 DTVLVCGSFHTVAHVMEV 413 +L GS H V+E+ Sbjct: 437 LRLLFIGSLHLAGEVLEL 454 >UniRef50_C7GYL0 Tetrahydrofolate synthase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7GYL0_9FIRM Length = 441 Score = 162 bits (411), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 128/413 (30%), Positives = 194/413 (46%), Gaps = 33/413 (7%) Query: 30 LGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRY 89 LGL+R++ + A LGV + VAGTNGKG+ C L+ IL A G K G+Y+SP+L Y Sbjct: 18 LGLDRMNRLMAELGVSCADFKIIHVAGTNGKGSVCTMLDKILRAHGIKTGMYTSPYLSNY 77 Query: 90 TERVRVQGQELP-ESAHTASFAEIESAR------GDISLTYFEYGTLSALWLFKQAQLDV 142 + + V G+ + E +E+A G++++T FE T AL+ FK+ + Sbjct: 78 RDSIAVDGRSISCEDLDRVGETVLEAADKLPKEDGELAVTEFEVITGLALYYFKEVGAEY 137 Query: 143 VILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG- 201 VILE GLGG LD+TNI A VAV+TSI+ DH D LG I + KAGI + A+V Sbjct: 138 VILETGLGGALDSTNIAPAKVAVITSISYDHMDVLGDSLAEIAKNKAGIIKEGATAVVNV 197 Query: 202 -EPEMPSTIADVAQEKGALLQR-------RGVEWN--YSVTDHDWAFSDAHGTLENLPLP 251 E E S I + +K A + R V++N +S+ D A S +G ++ L Sbjct: 198 DEEEALSVIKNEVCKKHANIVRADEAVKINSVDYNKKFSLVDMSTA-SQNYGRIKFSLLG 256 Query: 252 LVPQPNAATALAAL----RASGLEVSENAIRDGIASAILPGRFQIV---SESPRVIFDVA 304 N T +A + A G + + GRF++ + ++ D A Sbjct: 257 KHQLSNLKTVIATVGELKSAFGFCERHEITVEALGDVHFSGRFEVFEGDAGCADIVLDGA 316 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HN E L +K N ++LAV ML DK + L L +D + R + Sbjct: 317 HNVAGIEALEQNVKLYYPNAKILAVTSMLGDKQVDEILHRLCKFSNDVIFTEINNERRIS 376 Query: 365 AEQLLE-------HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 A ++LE + GN + +A+ A + D +L GS + + + Sbjct: 377 AHEMLEIAKQSEGNTGNYQEIPDTGKAFTQAYDSRRNYDLILFTGSLYMMGDI 429 >UniRef50_B1VGM7 Dihydrofolate synthase / folylpolyglutamate synthase n=28 Tax=Actinomycetales RepID=B1VGM7_CORU7 Length = 545 Score = 162 bits (411), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 126/383 (32%), Positives = 188/383 (49%), Gaps = 42/383 (10%) Query: 28 IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLV 87 ID LER+ ++ LG + + VAGTNGK + R +ES+L A + G +SPHL Sbjct: 105 IDPSLERIEMLMDLLGNPERSFATIQVAGTNGKTSVVRMIESLLRAFHRRTGRTTSPHLQ 164 Query: 88 RYTERVRVQGQELPESAHTASFAEIE----------SARGDISLTYFEYGTLSALWLFKQ 137 TER+ V G+ + + + EI+ +A G ++ FE A F Sbjct: 165 LVTERIAVDGEPIHPQDYIRMWREIQPMVEMVDAKSTAEGGPQMSKFEVLVALAYSAFAD 224 Query: 138 AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRS--- 194 A +DV ++E G+GG DATN+V++DV+V+T I +DHTD+LG I EKAGI +S Sbjct: 225 APVDVAVIETGMGGTWDATNVVNSDVSVITPIGMDHTDFLGDTLTEIAGEKAGIIKSRWD 284 Query: 195 --------EKPAIVG--EPEMPSTIADVAQEKGALLQRRG-----VEWNYSVTDHDWAFS 239 E AI+ EPE + + A E A + R G VE +V Sbjct: 285 REDLLTPPENIAIISEQEPEAMRVLLERAVEVDAAVARAGAEFGAVESTVAVGGQRLTIK 344 Query: 240 DAHGTLENLPLPLVPQPNAATALAA-------LRASG-LEVSENAIRDGIASAILPGRFQ 291 GT +++ LPL + A A A A G ++ + +R+G A+ PGR + Sbjct: 345 GLAGTYDDIFLPLSGEHQARNAATALAAVEAFFGAGGDRQLDVDKVREGFATVTSPGRLE 404 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKN---GRVLAVIGMLHDKDIAGTLAWLKSV 348 V +P V D +HNPH A L KA+ ++ R++ V+ +L DKD G LA L+ V Sbjct: 405 RVRATPSVFIDASHNPHGAAALA---KAVDRDFDFRRLIGVVAVLGDKDARGILAALEPV 461 Query: 349 VDDWYCAPLEGPRGATAEQLLEH 371 +DD ++ PR + L E+ Sbjct: 462 LDDVVITEVQSPRALPVDVLAEY 484 >UniRef50_A5V9W9 FolC bifunctional protein n=6 Tax=Sphingomonadaceae RepID=A5V9W9_SPHWW Length = 453 Score = 162 bits (411), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 124/351 (35%), Positives = 183/351 (52%), Gaps = 24/351 (6%) Query: 30 LGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVR 88 LGL+R++ + RLG + A P VF VAGTNGKG+TC L + + AAG V++SPHL+R Sbjct: 41 LGLDRIARLCDRLGNPERALPPVFHVAGTNGKGSTCAYLRAAIEAAGMSAHVFTSPHLIR 100 Query: 89 YTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVG 148 + ER+R+ G + ++A A AE+ I ++FE T +A F + D I+EVG Sbjct: 101 FNERIRIAGSLIEDAALAALLAEVLDVSEGIGASFFEVTTAAAFLAFSRTPADACIVEVG 160 Query: 149 LGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPS 207 LGGRLDATN++ D V + + LDH +LG E+I EKAGI + P + P+ Sbjct: 161 LGGRLDATNVIADPLVCGIAQLGLDHQSFLGDTIEAIAAEKAGIAKPGVPILT--LHYPA 218 Query: 208 TIAD----VAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLP-LVPQP---NAA 259 T+A+ +E GA +G W+ + + DA G L+ LPLP L Q NAA Sbjct: 219 TVANEIGRAIREAGAEWHVKGGSWDAAAYQGRLHYRDAQGKLD-LPLPGLAGQHQAMNAA 277 Query: 260 TALAALR-ASGLEVSENAIRDGIASAILPGRFQ------IVSESP---RVIFDVAHNPHA 309 A+A LR + + +A+R + A P R Q ++ P + D HNP A Sbjct: 278 LAVAMLRHQDAIAIPASALRAAMGWADWPARLQHLRGGALLDRLPPGSDLWIDGGHNPSA 337 Query: 310 AEYLTGRMKALPKNGRVL-AVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 + ++ R L V+G+L +KD G LA + V ++ P+ G Sbjct: 338 GRVIGDFLRGHVAPERPLHIVLGLLANKDAGGFLAAMGRVPAHFHMVPVPG 388 >UniRef50_D1CGA1 FolC bifunctional protein n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CGA1_THET1 Length = 451 Score = 162 bits (411), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 139/460 (30%), Positives = 213/460 (46%), Gaps = 58/460 (12%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M I A + S+ Y N + LE V L+ +G + +AGT GK Sbjct: 1 MTINSYADALRYIYSFADYERNKPRSPEGMHLENVRLLLESVGNPHEKLKLVHIAGTKGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 G+T + S+L+++GYKVG Y+SPHL + ER ++ Q + E EI+ A +++ Sbjct: 61 GSTSAMISSVLISSGYKVGTYTSPHLHTHRERYQINAQPVNEDTFVNVLNEIKPAADELA 120 Query: 121 ----LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDW 176 +T +E T A LF++ +D ++EVGLGGRLD+TN++ V+V+T+I+LDHT+ Sbjct: 121 KDRKVTTYEITTALAFKLFEEEDIDWGVIEVGLGGRLDSTNVIIPKVSVITAISLDHTEV 180 Query: 177 LGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDW 236 LG I EKAGI + P++P IA QE +L++R ++ N+S Sbjct: 181 LGDTLAKIAAEKAGIIK---------PQVPVVIAPQYQEAMEVLKQRALD-NHSQALIVD 230 Query: 237 AFSDAHGT-----------------LENLPL-------PLVPQPNAATALAALRASGLEV 272 +A T L N PL PL+ + AL A+ + L + Sbjct: 231 ELMEARNTQTEDLSSQSFTLHTKLCLHNQPLDSQSFTIPLIGRYQTDNALTAITTAWL-L 289 Query: 273 SENA--------IRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNG 324 S++A + +G+ + PGRF++V +P +I D AHNP + L +K L N Sbjct: 290 SQDAAPAINLTTLMEGLRNVKWPGRFEVVPGTPLIILDGAHNPESVGKLKNTVKELLSNK 349 Query: 325 RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQA 384 R + V G D G L L+ ++ PR E L + N V Sbjct: 350 RRIYVFGAGFGHDFHGMLEQLRE--EELIICKSIHPRAVPPETLSQIASNLGIKHQVRPT 407 Query: 385 WDAAMADAKA---EDTVLVCGSFHTVAHVMEVIDARRSGG 421 + A+ AK+ D V+V GS VA DAR + G Sbjct: 408 VEEALDLAKSLDDVDAVIVGGSLFVVA------DARLALG 441 >UniRef50_B7CA46 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7CA46_9FIRM Length = 386 Score = 162 bits (409), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 117/367 (31%), Positives = 178/367 (48%), Gaps = 35/367 (9%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 VAGTNGKG+T L +LM GY+VGV++SPHL+ +TER+RV + + + + E Sbjct: 42 VAGTNGKGSTSIWLRDLLMKKGYRVGVFTSPHLIHHTERIRVNDTCISLADWERIYDQYE 101 Query: 114 SARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDH 173 +T FE +L F + ++D I+E G+GGRLDAT +D ++T++ LDH Sbjct: 102 ELFSFHKMTMFEMDLWMSLAYFIEQKVDYCIIEAGMGGRLDATTALDYQACLITNVGLDH 161 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALL------QRRGV 225 T++LG E I EK+GIF+ PA+ E PE + VA L + + Sbjct: 162 TEYLGNTFEQIAYEKSGIFKPNVPALTTEDKPECRKVMELVADYMNTPLCFIDCQETDVL 221 Query: 226 EWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAI 285 WN G +L PL N + AL L G+ + EN I++ I Sbjct: 222 RWN--------------GMTFHLNPPLYQAKNLSLALETLNVLGIWLEENEIQEVIDHFQ 267 Query: 286 LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 GRF ++ ++P V+ D AHN H +T + AL KN +L +KD + L Sbjct: 268 WAGRFMVLRKAPLVLLDGAHNVHG---ITALIHAL-KNFHGKIYFSVLKEKDAPHMIELL 323 Query: 346 KSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 +++ D + R E+L G +V + + + D K ED+ L+CGS + Sbjct: 324 QTISKDITLVEISSARLYPLEKL------GYPIITVDEL-ISRLLDTK-EDS-LLCGSLY 374 Query: 406 TVAHVME 412 V V+E Sbjct: 375 YVGEVLE 381 >UniRef50_B5IFG1 FolC bifunctional protein n=2 Tax=Aciduliprofundum boonei T469 RepID=B5IFG1_9EURY Length = 422 Score = 161 bits (408), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 120/379 (31%), Positives = 176/379 (46%), Gaps = 38/379 (10%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI- 112 +AGTNGKG+ + SIL Y VG+Y+SPHLVRY+ER+ V +E+ E E+ Sbjct: 43 IAGTNGKGSVASAIYSIL-RKNYNVGIYTSPHLVRYSERIIVNDREISEDYIARFVREVK 101 Query: 113 ----ESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTS 168 E A+ + + T+FE T+ A F +D +LEVGLGGRLDATNIV ++ + + Sbjct: 102 PIIEELAKENRNPTFFEVSTMLAFEYFSYMSVDFAVLEVGLGGRLDATNIVMPEITSIVT 161 Query: 169 IALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWN 228 I LDHT LG I REKAGI + P ++GE + + +E + + R + Sbjct: 162 IDLDHTHILGDTIRDIAREKAGIIKPNVPVVIGENK-----KEAIEEIKRIAELRNAPY- 215 Query: 229 YSVTDHDWAFSDAHGTLENL---------------PLP---LVPQPNAATALAALRASGL 270 +++ D + F D H L L PLP + A +A L Sbjct: 216 HNIWD-EMEFEDVHIDLNGLRFKAHTPISTYTIETPLPGKHQITNMLVAIRIAELLQENY 274 Query: 271 EVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVI 330 +S + I DGI + RFQ+ P +IFD AHNP AA L ++ + + Sbjct: 275 SISHSDIEDGIKNIKWKDRFQVKRRRPLLIFDSAHNPSAARALVSTIRDVGIEEPTF-LF 333 Query: 331 GMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATA-EQLLEHLGNGKSFDSV---AQAWD 386 +L DK+I L + V ++ R T E ++EH K F V D Sbjct: 334 SILSDKNIDEFLKEISKVSKKIIVTEIDYERRRTELEDIVEHA--KKYFSEVIPIKNPCD 391 Query: 387 AAMADAKAEDTVLVCGSFH 405 A + E ++ GS + Sbjct: 392 ALKYAMENEKKIIATGSIY 410 >UniRef50_Q4FND2 FolC bifunctional protein (Folylpolyglutamate synthase/Dihydrofolate synthase) n=3 Tax=Candidatus Pelagibacter RepID=Q4FND2_PELUB Length = 422 Score = 161 bits (407), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 107/422 (25%), Positives = 206/422 (48%), Gaps = 24/422 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L + L+ LH K IDL L+R + +LG + ++ GTNGK +T + L +IL Sbjct: 3 LQKIVERLQKLHPKEIDLSLDRTKNLLEKLGNPQDQINCISIVGTNGKFSTIQALYAILK 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 A YK +Y+SPH+ + ER + L + F+E+E A +T+FE T++ Sbjct: 63 EADYKCNIYTSPHIQKINERFVFNNKPLTDDELANLFSEVEEANNQTQITFFEILTVAYF 122 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIGR---EK 188 K+ ++ ++E GL R DATNI+ ++A +VT+I LDH DWL + +++ + EK Sbjct: 123 HYAKKYPENINLIESGLFHRFDATNILKKNLASIVTAIGLDHLDWLPKEEQTVEKIIFEK 182 Query: 189 AGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-WAFSDAHGTL 245 + K + + E+ +I + ++ + +N+++ ++D + F D G L Sbjct: 183 TSTLLNSKIVVAKQSSNEISKSIENTIKDNTSKKIIFNKNYNFTLKENDFFYFEDEFGAL 242 Query: 246 ENLPLPLVP----QPNAATALAALRA-SGLEVSENAIRDGIA--------SAILPGRFQI 292 + LP P +P N +TA+A +R + ++++ I+ GI + G+ + Sbjct: 243 K-LPKPNLPGEFQLENVSTAIATVRQLTDYKITDEHIKSGITKIESIARLQELKSGKLKD 301 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 ++ + + D +HNP A+ L +++L N + ++GM+ +KD +++ K + Sbjct: 302 LTSNNLLFVDGSHNPLGAKVLNEYLQSLNCNKHI--ILGMMANKDHNEYMSYFKDIKSLT 359 Query: 353 YCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDA-AMADAKAEDTVLVCGSFHTVAHVM 411 P +L E + N ++ + +A + D + D +L+ GS + V+ Sbjct: 360 TIDIPNQPNAIKGSELKEKIKNFENINYKNSIEEAISSIDLQENDIILITGSLYLAGEVL 419 Query: 412 EV 413 + Sbjct: 420 NL 421 >UniRef50_C4V4R4 Possible tetrahydrofolate synthase n=2 Tax=Selenomonas RepID=C4V4R4_9FIRM Length = 433 Score = 161 bits (407), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 120/352 (34%), Positives = 180/352 (51%), Gaps = 26/352 (7%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L YL+ L++ I LGL R+ + ARLG + + V +AGTNGKG+ + ++++ A+G Sbjct: 7 LHYLDELNTFGIRLGLARMEELCARLGHPERSYRVIHIAGTNGKGSVTQMMDAVCRASGI 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE------SARGDISLTYFEYGTLS 130 + G Y SPHLV YTER+ V G+E+ E A + +A G T FE T Sbjct: 67 RSGRYLSPHLVSYTERMSVGGEEIGEEQFAALLTRVSAAADAMTAEGHEHPTQFEALTAL 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A F + + +V ++E GLGG LD+TN+V ++ ++T++A+DH D G I KAG Sbjct: 127 AFLYFAEEKAEVAVVETGLGGLLDSTNVVLPELTIITNVAMDHADRCGGTLAGIAEHKAG 186 Query: 191 IFRSEKPAIV---GEPEMPSTIADVAQEKGALLQRRGVEWNYSV--TDHDWAFSDAHGTL 245 I + P I GEP S IA A+E GA L G +++ + ++ H + Sbjct: 187 IIKEGVPVITAAAGEP--LSIIAARAEELGADLFVYGEDFSAQMLRMENGGQCVSFHSVV 244 Query: 246 ENLPLPL-------VPQPNAATALAALRASGLE---VSENAIRDGIASAILPGRFQIVSE 295 P P NAA A+ A E ++E+A+R + + P RF+I+S Sbjct: 245 SRAPEPFEIALAGPYQAENAALAIMAAELMAPEDERITEDAVRTALRTVHHPARFEILSC 304 Query: 296 SPR-VIFDVAHNPHAAEYLTGRMKA-LPKNGRVLAVIGMLHDKDIAGTLAWL 345 + V+ D AHNP + L + A P RV ++G+L DKDI LA L Sbjct: 305 GGQTVVVDGAHNPAGMQALRAGLDAYFPAQPRVF-LLGILKDKDIDRMLAIL 355 >UniRef50_Q05865 Folylpolyglutamate synthase n=5 Tax=Bacillus subtilis group RepID=FOLC_BACSU Length = 430 Score = 160 bits (406), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 120/403 (29%), Positives = 189/403 (46%), Gaps = 23/403 (5%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GL R+ + ARLG + F VAGTNGKG+T + S+L AGY VG ++SP+++ + Sbjct: 23 GLGRMKQLMARLGHPEKKIRAFHVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFN 82 Query: 91 ERVRVQGQELPESAHTASFAEIESARGDISL------TYFEYGTLSALWLFKQ-AQLDVV 143 ER+ V G + + TA +++ + T FE T A F + ++D V Sbjct: 83 ERISVNGIPISDEEWTALVNQMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFV 142 Query: 144 ILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI--VG 201 I E GLGGR D+TN+V+ + V+TSI DH + LG E I EKAGI + P + V Sbjct: 143 IFETGLGGRFDSTNVVEPLLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVT 202 Query: 202 EPEMPSTIADVAQEKGALLQR---RGVEWNYSV--TDHDWAFSDAHGTLENLPLPLV--- 253 +PE I A+ A Q V +N ++F E++ L+ Sbjct: 203 QPEALQVIRHEAERHAAPFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTH 262 Query: 254 PQPNAATALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHA 309 + NAA ++ A + + +S+ A+R G+ A PGR ++V E P V D AHN Sbjct: 263 QRQNAALSILAAEWLNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEG 322 Query: 310 AEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLL 369 E L MK N R+ V L DK + L+++ + A + PR + A+ L Sbjct: 323 VEKLAETMKQRFANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLY 382 Query: 370 E--HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 + + N + + + + VL+ GS + ++ + Sbjct: 383 DASEISNKSWSEDPDDVIKFIESKKGSNEIVLITGSLYFISDI 425 >UniRef50_C2KWA8 Possible tetrahydrofolate synthase n=1 Tax=Oribacterium sinus F0268 RepID=C2KWA8_9FIRM Length = 447 Score = 160 bits (406), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 112/380 (29%), Positives = 186/380 (48%), Gaps = 24/380 (6%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 +AG+NGKG+ ++L+ IL +GYK G+Y SPH+ ER + G+ + + ++ Sbjct: 58 IAGSNGKGSVAKSLQQILSLSGYKTGMYISPHIEIMNERYTIDGEMISDEDLKRLCLKMR 117 Query: 114 SARGDISL---TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSI 169 + FE T A F + +D V+LEVGLGGRLDATN++ +++V+ I Sbjct: 118 ELSESLEEEKPNSFEMLTALAFCYFLEKGVDYVVLEVGLGGRLDATNVIPHKELSVIAHI 177 Query: 170 ALDHTDWLGPDRESIGREKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEW 227 L+HT LG E I REK GI + P ++ +PE+ I + +EK A L ++ Sbjct: 178 GLEHTAILGDTLEEIAREKGGIIAKDTPVVLMHQKPEVMEEIRRICKEKNAKLHITNPKY 237 Query: 228 NYSVTDH------DWAFSDAHGTLENLPLPLVPQPNA---ATALAALRASGLEVSENAIR 278 +S + H +++ + H +L L NA A+ L+ G+ + E+ ++ Sbjct: 238 FHSYSFHIDNGYQYFSYRERHEYALSL-LGDYQLDNAMVICDAIDCLKERGISIPEDCVK 296 Query: 279 DGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDI 338 G+ + PGRF+I+ + P +I D AHNP A L ++ L N + ++ DKD Sbjct: 297 QGLMTVTWPGRFEILKKRPLIILDGAHNPQAVNSLVRSIEMLFPNYKKRIFFSVMADKDY 356 Query: 339 AGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE----HL-GNGKSFDSVAQA--WDAAMAD 391 L LK+ + +E RG E L + H G + +S+ + W+ Sbjct: 357 MTMLELLKNNTLSFSFFQVESHRGQNPEILKQQWQSHFDGEIRCPESLEEGLEWNLNAVK 416 Query: 392 AKAEDTVLVC-GSFHTVAHV 410 + E T+L+C GS + V + Sbjct: 417 KEEEKTLLLCLGSLYQVGQI 436 >UniRef50_C2BRT3 Possible tetrahydrofolate synthase n=3 Tax=Mobiluncus RepID=C2BRT3_9ACTO Length = 549 Score = 160 bits (405), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 113/377 (29%), Positives = 184/377 (48%), Gaps = 25/377 (6%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 A + + L I+ LE V V LG + + GTNGK + R +E++L Sbjct: 112 AIYETLLTRRAEHQIEPSLEPVRGVLDYLGNPQELFHSVHITGTNGKTSIARMIEALLAE 171 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-------ARGDISLTYFEY 126 GY+ G ++SPHLV ER+ + L ++ +IE+ A L++FE Sbjct: 172 LGYRTGRFTSPHLVDVCERISIDQAPLTTEQFVQAYEDIEAQLALWEHAHPGRRLSFFEV 231 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T+ A LF +DV ++EVG+GGR DATN++DAD AV+ I+L+H WLG +I R Sbjct: 232 MTVMAYALFADVPIDVAVVEVGMGGRWDATNVIDADTAVIGPISLEHEQWLGKGLTNIAR 291 Query: 187 EKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNY-----SVTDHDWAFS 239 EKAGI R ++ A+V + E + I D A + +L+ G ++ +V Sbjct: 292 EKAGIMRPQRVAVVAKQPDEALAVIRDTAAAEDVVLRYEGEDFEVLRRVPAVGGQVLDIR 351 Query: 240 DAHGTLENLPLPLVPQ---PNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQIVS 294 +++ LPL + NAA AL A+ A G+ + ++ + + PGR +++ Sbjct: 352 TPAAVYQDIYLPLYGEFQAENAALALTAVEAQLGGMPLHGESVERALGTVKSPGRLEVLH 411 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGM---LHDKDIAGTLAWLKSVVDD 351 +P ++ D HNP AA+ L +A+ + R +G+ + DKDI L ++ + + Sbjct: 412 STPMIVADAGHNPGAAQALR---RAIEDDFRFEHTVGIYSAMADKDIETVLGIMEPTIAE 468 Query: 352 WYCAPLEGPRGATAEQL 368 + G R A E L Sbjct: 469 LIVTQMPGERAAKVEDL 485 >UniRef50_Q6G1D4 Folylpolyglutamate synthase n=2 Tax=Bartonella RepID=Q6G1D4_BARQU Length = 439 Score = 160 bits (405), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 119/363 (32%), Positives = 178/363 (49%), Gaps = 35/363 (9%) Query: 24 HSKTIDLGLERVSLVAARLGV--LKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVY 81 + K DL LER+ + +G LK AP + +AGTNGKG+ ++L +AGY+V VY Sbjct: 17 YPKKFDLSLERILRLLKSIGSPHLKLAPIIH-IAGTNGKGSASAICRALLESAGYRVHVY 75 Query: 82 SSPHLVRYTERVRV----QGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQ 137 SSPHLV + ER R+ GQ + E + ++ A +T FE T +A LF Sbjct: 76 SSPHLVNWNERCRLGQTGSGQLVTEELLAETIHQVVKANDQKPITVFEILTAAAFILFST 135 Query: 138 AQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIFRSEK 196 D VILEVGLGG DATN+++ V+++ I DH +LG I +K GI + + Sbjct: 136 HPADCVILEVGLGGHFDATNVINKPAVSLIMPIDYDHETFLGKTIAQIAFQKGGIIKPQV 195 Query: 197 PAIVGEPE------MPSTIADVAQEKGALLQRRGVEWNY-SVTDHDWAFSDAHGTLENLP 249 P ++G+ E + +T+AD + +L E +Y S T+H + L NLP Sbjct: 196 PVVIGKQEHDETLSVLTTLADKNKAPYSLF-----EQDYQSYTEHGHMVFQNNQGLINLP 250 Query: 250 LP----LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSE-------SPR 298 LP + NA +L A+ +G +SE AI + + P R Q ++ SP Sbjct: 251 LPNLIGMHQIANAGASLEAIYQAGFRLSEQAISHALQNIYWPARMQHLTHGNLVDQMSPG 310 Query: 299 VI--FDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 + D HNP A + + + K N ++ + ML+ KD G L ++VD Y Sbjct: 311 IDLWLDGGHNPAAGKVVAAELIQWKKKSNRPIIMIASMLNTKDTVGYFRPLANLVDKVYT 370 Query: 355 APL 357 PL Sbjct: 371 IPL 373 >UniRef50_D2RA71 Bifunctional protein FolC n=3 Tax=Bifidobacteriaceae RepID=D2RA71_GARVA Length = 485 Score = 160 bits (404), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 116/355 (32%), Positives = 184/355 (51%), Gaps = 30/355 (8%) Query: 24 HSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSS 83 H+KT +L L+R+ L+ LG + + V + GTNGKG+T R ESI A G + G+Y+S Sbjct: 27 HNKT-NLDLDRMRLILDILGHPEQSMRVIHITGTNGKGSTARMAESICRAYGLRTGLYTS 85 Query: 84 PHLVRYTERVRVQGQELPESAHTASFAEIES----------ARGDISLTYFEYGTLSALW 133 PHL R ER+ + GQE+ ++ + +++ A G +++FE T A+W Sbjct: 86 PHLERVNERIMIDGQEISDNQFVDVWDQMKDIIDMVDARMEADGKPKMSFFEVLTAMAIW 145 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F A +DV ++EVG+GG DATN+++AD A++ + +DH WLG E I R KAGI + Sbjct: 146 AFADAPVDVAVMEVGMGGEWDATNVMNADAAIIGPVDMDHMQWLGNTVEEIARTKAGIIK 205 Query: 194 SEKPAIVG----EPEMPSTIADVAQEKGALLQRRG---------VEWNYSVTDHDWAFSD 240 I+G E ++ I +VA+ A L R V +V Sbjct: 206 PNCTVILGPQPHEAKVLPIIKEVAERNHATLLRDSSYGDGELEVVSRTPAVGGQVVTLRT 265 Query: 241 AHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDG--IASAI----LPGRFQIVS 294 GT E++P+ + A ALAAL A+ + + + DG +A A+ +PGR + V Sbjct: 266 PLGTYEDVPVDKFGKHQAHNALAALAAAEVVLPVSGALDGDLVAEALSQVKVPGRIEQVR 325 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 SP +I D HN +AAE L ++ +++ V+ M+ DK + L L+ ++ Sbjct: 326 TSPTIIIDGGHNVNAAESLRETIEENYHFEQLIGVVAMMADKQVEEYLGVLEPIL 380 >UniRef50_D1PK55 Tetrahydrofolate synthase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PK55_9FIRM Length = 432 Score = 160 bits (404), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 132/416 (31%), Positives = 192/416 (46%), Gaps = 55/416 (13%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GLER+ + A LG + + +AGTNGKG+ +IL AAGYK G+ SP++V + Sbjct: 22 GLERMKNLLAHLGNPEESLQCVHIAGTNGKGSLAAMTAAILTAAGYKTGLTISPYVVDFR 81 Query: 91 ERVRVQGQELP----ESAHTASFAEIESAR--GDISLTYFEYGTLSALWLFKQAQLDVVI 144 ER ++ G+ +P S IE+ R G FE T AL F + + D+V+ Sbjct: 82 ERFQIDGEMIPPRTLASLTQKVLGAIEAIRQEGGEEPVQFEAVTALALLWFAREKCDLVV 141 Query: 145 LEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEP 203 LE GLGGR DATN V VA +T I DH + LG + I EKAGI + E A+V P Sbjct: 142 LETGLGGRYDATNAVPHTLVAAITKIGYDHMELLGDTLDKIAAEKAGIIK-EGCAVVCYP 200 Query: 204 EMPST--------------------IADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 + P+ + D+ Q G L+ R +Y AF AH Sbjct: 201 DQPAEAMGPILTAAAEAHTSIITPELEDIRQLPGKTLENR---IDYGGYQASLAFPGAH- 256 Query: 244 TLENLPLPLVPQPNAAT-----ALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 Q N A ALA R G E+S++AI G+A+A +P R +++ P Sbjct: 257 -----------QANHAAMAVEIALALWREYGYEISDDAILQGLAAARMPARIEVLRRHPL 305 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 ++ D HNP L ++ ++ V+GML DKD L L Y Sbjct: 306 LLLDGCHNPDGTRALAETLQKAKYEENLVGVLGMLADKDYQKMLEILAPCFAKVYTVTPN 365 Query: 359 GPRGATAEQLLE----HLGNGKSFDSVAQAWDAAMADAKAEDT--VLVCGSFHTVA 408 PR + E L + H+ + ++ +V +A AA+ A+ + V+VCGS + A Sbjct: 366 CPRALSGEDLQKAARFHM-DAEAAATVPEALRAAVRYAEDHNLAGVVVCGSLYLAA 420 >UniRef50_A8MIR1 FolC bifunctional protein n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MIR1_ALKOO Length = 439 Score = 160 bits (404), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 116/430 (26%), Positives = 200/430 (46%), Gaps = 40/430 (9%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + +++ +S L LE + ++ LG + +AGTNGKG+T + S+L A GY Sbjct: 7 VQFIDRSYSYGTKLDLEHMKILLQILGNPQNQLKFIHIAGTNGKGSTSSFIHSMLKAEGY 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG--------- 127 +VG+++SPHL YT+R+R+ G + + FA S + ++E G Sbjct: 67 QVGLFTSPHLHCYTDRIRINGVNISKE----DFARYTSMVEETIAPFYEQGFNHPALFDI 122 Query: 128 -TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIG 185 TL A+ F + +D V+LEVGLGG DATNI+ +A V+T I +DH D LG D + I Sbjct: 123 VTLVAMMYFAKENVDYVVLEVGLGGLNDATNIISQSLASVITPIGIDHVDILGTDLKQIA 182 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGA---LLQRRGVEWNYSVTDHDWA--- 237 KAGI +S+ I +P + + + A ++ A LL++ + S+ D+ Sbjct: 183 YHKAGIIKSQGRVISTWQDPIVEEVLVETAAQQNASLCLLRKEQI----SIIHQDFKEQI 238 Query: 238 --FSDAHGTLENLPLPLVPQPN------AATALAALRASG-LEVSENAIRDGIASAILPG 288 + +G L + + ++ AA L LR L +S +I G+ G Sbjct: 239 FHLNTPYGILRDCKIRMIGDHQIFNGALAALTLIILREDQILSISNESIYQGLYENYWAG 298 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 R +++ ++P ++ D AHN +E L + N ++ +IGML DKD+ G L L Sbjct: 299 RLELLQDNPLILIDGAHNVQGSEVLASALTKYFNNKKITLIIGMLKDKDVDGVLNNLIPF 358 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDA----AMADAKAEDTVLVCGSF 404 P+ ++L + + Q + A+ +A ++ + GS Sbjct: 359 AHKVIFTKPNNPKAMDPQELANRVNFFGKETYITQTIEESVVLALENASLDEITIFTGSL 418 Query: 405 HTVAHVMEVI 414 + + ++I Sbjct: 419 YLIGDARKII 428 >UniRef50_D0MSD1 Folylpolyglutamate synthase, putative n=1 Tax=Phytophthora infestans T30-4 RepID=D0MSD1_PHYIN Length = 573 Score = 159 bits (403), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 128/394 (32%), Positives = 190/394 (48%), Gaps = 45/394 (11%) Query: 9 AASPLASWLSYLENLHS----KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 AA A++ L+ L+ + LGLE + + A G + VAGTNGKG+ Sbjct: 93 AAETSATYEMLLQRLYQVNRFSAVKLGLENMQKLNAAFGDPASQFEIIHVAGTNGKGSVA 152 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE--SARGDISLT 122 + L +G+K G++ SPH+ + ERV+V GQ + ES + +EI SA+ I T Sbjct: 153 FKVAKALERSGHKTGLFVSPHVACFRERVQVNGQLISESDVCDALSEIFNISAQLRIPAT 212 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 +FE T+ A F + +D V+LE GLGGRLD+TNIV ++V+TSI LDHT LG RE Sbjct: 213 FFEITTMLAFMHFAKQGVDCVVLETGLGGRLDSTNIVTPALSVITSIGLDHTRILGNTRE 272 Query: 183 SIGREKAGIFRSEKPAIVGEPEMP-STIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 +I REKAGI ++ P +VG P P + + + A A L R ++ ++ D D+ +A Sbjct: 273 AIAREKAGIIKANVPVVVG-PNTPVNVMMEFAARNNAPLVRVPLQADF---DEDY---NA 325 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAIL----PGRFQIV---- 293 T + Q N +L R+ + + + +A L P RFQ++ Sbjct: 326 ENTA--IAREACVQLNTLHSLKTGRSRAAQKLCVDLTNKRVNAALEARPPCRFQVLHLMR 383 Query: 294 ----SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 V+ DVAHNP A + L G + + + V G DK I L + VV Sbjct: 384 PNSKERKMTVVLDVAHNPQAIDKLVGLLHKQFPDKKFRFVCGFSADKAINKVLDKITEVV 443 Query: 350 DDWYCAPLEG---------------PRGATAEQL 368 D + P E PRGA+ E++ Sbjct: 444 RDTH--PDESDEELQERIHLVKANHPRGASLEEI 475 >UniRef50_A9QPJ9 Folylpolyglutamate synthase n=1 Tax=Methylacidiphilum infernorum V4 RepID=A9QPJ9_METI4 Length = 441 Score = 159 bits (403), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 129/424 (30%), Positives = 200/424 (47%), Gaps = 26/424 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L++L + LGL+ V +A +G +AGTNGKG+T + S L A+G Sbjct: 15 LNFLGQARKVGMKLGLQNVQRLAMEMGNPHENLNFIHIAGTNGKGSTAAFIASALQASGL 74 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA-------RGDISLTYFEYGTL 129 K G++SSPHLV ER++V G+ + + + EI+ + D + T+FE + Sbjct: 75 KTGLFSSPHLVTIRERIQVNGKPITKIQFSRWVLEIQGKIQKIRQLKEDFTCTFFEIMAI 134 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +A+ F ++++D V+ E GLGGRLDATN V ++V+T+I DHT +LG E I EKA Sbjct: 135 AAILEFSRSKVDWVVWETGLGGRLDATNFVIPRLSVITNIDYDHTQFLGETLEEIAAEKA 194 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT------DHDWAFSDAHG 243 GI + P +VG + +V ++ A + VE SV+ D+ + + G Sbjct: 195 GIIKEGVPVVVG--NLSHGALEVVKKCAARVGAPVVEVFRSVSLKSIKLDYKEHWVEIAG 252 Query: 244 TLENLPLPLVPQ-PNAATALAALR---ASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 L L Q NAA A +L+ + + +I+ G + PGRFQ++ E P Sbjct: 253 FPFCLGLTGYHQLENAACAFVSLKLLFSKEDPLDIKSIQQGFRAVDWPGRFQLLWEKPLC 312 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 I D AHN A L + + + V G+L DK+ A LK + Sbjct: 313 IVDGAHNVGAVVQLVANWEKIFGDEPYHLVFGVLKDKNFALMADVLKRKAQEVTLIKPPT 372 Query: 360 PRGATAEQLLEHLGNGKSFDSVAQAW-DAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 RG ++L G+ K V W D ++ + +LV GS + + HV+ Sbjct: 373 VRGLEPQKLFPFFGDVKL--RVCSCWSDFKLSLDRTSLPILVTGSLYLIGHVL----VEE 426 Query: 419 SGGK 422 GGK Sbjct: 427 CGGK 430 >UniRef50_Q6KZL1 Folylpolyglutamate synthase/dihydrofolate synthase n=3 Tax=Thermoplasmatales RepID=Q6KZL1_PICTO Length = 435 Score = 159 bits (402), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 127/421 (30%), Positives = 200/421 (47%), Gaps = 30/421 (7%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + + L+YL L + I LGL+ A LG + +AGTNGKG+ + +IL Sbjct: 1 MDNILNYLYELKREGIKLGLDTTRAFAEHLGNPQDKYKKIHIAGTNGKGSISSYIYNILR 60 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD------ISLTYFEY 126 Y G+Y+SPHL+++ ER+ + +E+ + +F D ++ T+FE Sbjct: 61 QR-YNTGLYTSPHLIKFNERI-IFNKEMISDDYIINFISENRDYIDKLSKIKMNPTFFET 118 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T+ A F D +EVGLGGRLD+TNI+ +++++ I +H LG SI Sbjct: 119 TTVMAFKYFYDMHADYAAIEVGLGGRLDSTNIIIPEISIIGQIGYEHYQKLGCSLTSIAY 178 Query: 187 EKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALL-----QRRGVE---WNYS-VTDHD 235 EK GI + P ++ + PE+ + I ++Q + + L + E +N+ V D Sbjct: 179 EKGGIIKPGIPVVLQDKKPEVLAEIKKLSQVRKSKLILSEDYSKSTEPELYNFKMVFDLK 238 Query: 236 WAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSE 295 ++ H NL L V N TA+AAL ++++ + GI AI GR +I+ Sbjct: 239 TPLNEYHIESNNLGLYQV--KNIKTAVAALENMDTSINKHDVESGIDKAIWHGRMEIIRA 296 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 SP VI D AHNP AA L K K + L +IGML DKD+ L ++ + D Sbjct: 297 SPLVIIDSAHNPPAASNLVPSFKKFIKK-KPLLLIGMLSDKDVFSFLTIMRQLSDKIVLT 355 Query: 356 PLEGPRGATAEQLLEHLGNG-----KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 P A ++ + + K A+D ++ K D VLVCGS + + + Sbjct: 356 MPNEPDRALDPDNIKDIASSIYRDVKIIKDPLSAYDYSL---KNSDCVLVCGSMYLIGDI 412 Query: 411 M 411 M Sbjct: 413 M 413 >UniRef50_B8J1M9 FolC bifunctional protein n=1 Tax=Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774 RepID=B8J1M9_DESDA Length = 444 Score = 159 bits (401), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 124/365 (33%), Positives = 174/365 (47%), Gaps = 46/365 (12%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFV-FTVAGTNGKGTTCRTLESILMAAGYK 77 +L+ L +D+GL+R+ + LG+ +P PFV V GTNGKG+T L S+ + G + Sbjct: 14 HLDGLGLFHMDMGLDRMRRALSILGLARP-PFVTVQVLGTNGKGSTAAFLSSLCQSHGLR 72 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQ 137 G+Y+SPH V TER+R+ G P I +A + LTYFE+ T+ AL F++ Sbjct: 73 TGLYTSPHFVSPTERIRIDGHPWPPDLWPPQADSIMNAVPE--LTYFEFLTVLALLAFRE 130 Query: 138 AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKP 197 Q+DV +LE GLGG DAT V AD+ T IA+DH D LG D +I R+KAG R Sbjct: 131 EQVDVAVLEAGLGGSHDATTAVSADLTCFTPIAMDHKDVLGADLAAIARDKAGAIR---- 186 Query: 198 AIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVP--- 254 P +P A + +L+ + WA + L P VP Sbjct: 187 -----PNVPVCAARQFPQATRVLENAAAACKAPLV---WA--------DTLEAPFVPGLA 230 Query: 255 ----QPNAATALAALRASGLEVSENAI-----RDGIASAILPGRFQIVSES---PRVIFD 302 + NAA AL A R + +N + G+A A +PGR Q + + P ++ D Sbjct: 231 GPHQRDNAALALTAWRRLAPMLGKNPADAALQQQGLARAFVPGRLQAIPAADGLPPLLLD 290 Query: 303 VAHNPHAAEYLTGRMKALPKNG--RVLAVIGMLHDKDIAGTLAWLKSVVDDW--YCAPLE 358 AHNPH L + AL + G AV L DKD LK ++ + L Sbjct: 291 GAHNPHGMAAL---VNALNQTGVRPAAAVFSCLGDKDWHSVAGMLKKILGHTPVFIPALH 347 Query: 359 GPRGA 363 PR A Sbjct: 348 NPRAA 352 >UniRef50_A8UBK8 Folyl-polyglutamate synthetase n=1 Tax=Carnobacterium sp. AT7 RepID=A8UBK8_9LACT Length = 434 Score = 159 bits (401), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 121/415 (29%), Positives = 203/415 (48%), Gaps = 37/415 (8%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GL+R+ + +++G + +AGTNGKG+T L +L A G VG Y+SP++ + Sbjct: 23 GLKRMEWMLSQVGHPERKFKSIHIAGTNGKGSTLAFLRGMLEANGQIVGTYTSPYIELFN 82 Query: 91 ERVRVQGQELPESAHTASFAEI---------ESARGDISLTYFEYGTLSALWLFKQAQLD 141 ER+ V G L + A A I ++ G+ S FE T+ L F + D Sbjct: 83 ERISVNGDPLSD-AEILRLANIVYPLTKELEKTILGEPS--EFEIITMMMLLYFGEGHAD 139 Query: 142 VVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG 201 VV++EVG+GG D+TN++ V+V+T+I LDH + LG I KAGI ++ P ++G Sbjct: 140 VVLIEVGIGGTYDSTNVITPIVSVITTIGLDHMNLLGDTLSEIAGNKAGIIKATVPVVIG 199 Query: 202 E--PEMPSTIADVAQEKGALLQRRG-----VEWNYSVT-DHDWAFSDAHGTLENLPLPLV 253 + E + I + A E+ + L + +W T + F D L + + ++ Sbjct: 200 KIGKEAMTVIENKAAEQDSTLLKYNQDFFVTKWQTLPTWGEQFVFEDDFIRLSPIQIEML 259 Query: 254 PQ---PNAATALAALRA----SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 + NAA A+ LR +GL ++ + G+ PGRF+ ++E P ++ D AHN Sbjct: 260 GRHQVENAAVAVETLRVYSHETGLAINHEKLLSGLKHTFWPGRFERINEQPLLVLDGAHN 319 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD-WYCAPLEGPRGATA 365 HA + L +K V ++ + DK+I G + L+ + + + PR A Sbjct: 320 EHAMKTLIETIKKNFAQQEVYIIMATMRDKNIQGMVDQLEEIPNSHLILTSFDYPRAAGI 379 Query: 366 EQLLE-HLGNGKSFDSVAQAWDAAMADAKAE----DTVLVCGSFHTVAHVMEVID 415 E+L + L NG +V + W A+ D+ E VLV GS + ++ V + ++ Sbjct: 380 EELSKVALKNG----AVTEHWQKALVDSLNEMDETGIVLVTGSLYFISEVRKYLN 430 >UniRef50_C6HY59 Folylpolyglutamate synthase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HY59_9BACT Length = 465 Score = 158 bits (400), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 108/323 (33%), Positives = 156/323 (48%), Gaps = 34/323 (10%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 + L L + GLERV LG + P F + GTNGKG+T ++SIL AGY+ Sbjct: 9 TILSKLLRFGVRPGLERVDAALTALGHPERGPLTFQIVGTNGKGSTAAFIDSILRQAGYR 68 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSALWLF 135 G ++SPHL ER+ + G+ L + +A E+ + G I LT+FE+ T+ A F Sbjct: 69 TGRFTSPHLTDIRERISISGEMLSPESFSALVREVAALDGSLQIGLTFFEFLTVMAHVAF 128 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 ++A++D V+LE GLGGR DAT + V V+T ++LDH + LGP I EK + R Sbjct: 129 QRAEVDCVVLEAGLGGRWDATTVSRPIVTVLTGVSLDHEEILGPGISRIFEEKVAVGRRG 188 Query: 196 KPAI--VGEPEMPSTIADVAQEKGAL-----------------------LQRRGVEWNYS 230 +P + + +P + D A+ G L L+ RG Y Sbjct: 189 RPFVANLKDPSLRGLFLDRARLVGFLPVLSGRDFEARWEDEAPLPSVNGLEGRGRRVLYQ 248 Query: 231 VTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRF 290 FS + N A+AA+ S L +S A R+GI+ A PGRF Sbjct: 249 GRWGRRTFSSGMSAAYQV-------ENVGAAVAAIEWSPLPISLTAFREGISRAEHPGRF 301 Query: 291 QIVSESPRVIFDVAHNPHAAEYL 313 + +S P ++ D AHNP A E L Sbjct: 302 ETISRHPAILLDGAHNPEAMERL 324 >UniRef50_A7HJX6 FolC bifunctional protein n=3 Tax=Thermotogaceae RepID=A7HJX6_FERNB Length = 435 Score = 158 bits (400), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 106/332 (31%), Positives = 179/332 (53%), Gaps = 20/332 (6%) Query: 27 TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 T+ LGL R+ + +++G F V G+NGKG+ LE++ G+ V + SPHL Sbjct: 21 TMKLGLFRIEQLLSKMGNPHLGVKFFHVTGSNGKGSVTTFLENLTYYHGHNVTGFYSPHL 80 Query: 87 VRYTERVR-----VQGQELPESA-HTASFAE-IESARGDISLTYFEYGTLSALWLFKQAQ 139 ER + +E ++A + +AE ++ + S ++FEY T L K Sbjct: 81 STILERFHWNTNLINQEEFVDAAEYVKKYAEEMDKIGEEFSPSFFEYMTAMYFHLTKVKN 140 Query: 140 LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI 199 + +EVGLGGR D+TN++ V+V+T+I+L+HT+ LG E I EKAGI +S P + Sbjct: 141 AEFGSVEVGLGGRFDSTNVITPVVSVITTISLEHTNVLGNTHEEIAFEKAGIIKSGVPVV 200 Query: 200 VGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDW--AFSDAHG--TLENLPLPL- 252 +GE E I ++A+E+G+ + G +++ V +D+ + +G T++N+P+ L Sbjct: 201 IGEMPEEAKIVIKNIAKERGSKVYEYGKDFSAEVVKYDFNNNIYNYYGDSTVKNIPVRLN 260 Query: 253 -VPQ-PNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 V Q N A AL A ++ E +++ ++A +PGRF++ +I D +HNP AA Sbjct: 261 GVHQLYNLAIALKAYETVE-KLYEEKVQNAFSNAFIPGRFELFD---GLILDGSHNPQAA 316 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTL 342 E ++ N + +A+ G++ DKD G L Sbjct: 317 EAFVSNIELYFSNKKRVALFGIVDDKDKMGVL 348 >UniRef50_C9KNY5 Tetrahydrofolate synthase n=2 Tax=Veillonellaceae RepID=C9KNY5_9FIRM Length = 439 Score = 158 bits (399), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 130/433 (30%), Positives = 204/433 (47%), Gaps = 39/433 (9%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 +SYLE L I LGL R+ + L + + V GTNGKG+ +E +L +G Sbjct: 12 ISYLEGLKIFGIRLGLTRIERLLELLDMPQDRYRTIHVTGTNGKGSVSAMVEGVLRRSGI 71 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAE---IESARGDISL-------TYFEY 126 G YSSPHLV YTER+RV GQ + E FAE + A+ D+ L T FE Sbjct: 72 HTGFYSSPHLVSYTERIRVDGQNISEQ----DFAEGMTVIRAKIDMMLAEGAECPTQFEV 127 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T + F + Q++ ++EVGLGG LD+TN++ +V+V+T++ ++H D LG +SI Sbjct: 128 LTALGFYYFAKCQVEYAVIEVGLGGTLDSTNVITPEVSVITNVTMEHADKLGGTLQSIAE 187 Query: 187 EKAGIFRSEKPAIV---GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 KAGI + P + GEP I VA+EK A + G ++ D Sbjct: 188 NKAGIIKEGVPVVTAAKGEP--LEVIRAVAEEKNADIFVAGEDFCSQFLSCDGRTQKLEF 245 Query: 244 TLENLPLPLVPQ----------PNAATALAALR---ASGLEVSENAIRDGIASAILPGRF 290 T E L + P N+A AL +R ++ + + + P RF Sbjct: 246 TSELLGIDHEPYELHLLGVHQVENSAVALMTIRLLHNIDDRITMKTVTEALRLVSWPARF 305 Query: 291 QIVSESPR-VIFDVAHNPHAAEYLTGRM-KALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 + + + ++ D AHNP + L + + P RVL ++G+L DKDI L L Sbjct: 306 ERLELGQQAIVVDGAHNPAGMKALRESLDEIFPAEERVL-LLGILKDKDIDTMLDILLRP 364 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSF 404 D + R +A LL + + ++F++ +A + A+ A E +++ GS Sbjct: 365 NDTVVVTVPQSERADSAADLLRRVAPAVQHVEAFENNTEALNRALELANGEKLLVIAGSL 424 Query: 405 HTVAHVMEVIDAR 417 + V V +++ R Sbjct: 425 YLVGGVRQMLLKR 437 >UniRef50_Q1IVH6 FolC bifunctional protein n=2 Tax=Acidobacteria RepID=Q1IVH6_ACIBL Length = 447 Score = 158 bits (399), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 120/353 (33%), Positives = 167/353 (47%), Gaps = 42/353 (11%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 +AGTNGKG+T TL SIL+AAGYK G+Y+SPHLV+ ER R+ G ++ ++ TA++ +E Sbjct: 49 IAGTNGKGSTAATLSSILLAAGYKTGLYTSPHLVKINERFRINGSQVNDAEFTAAYEHVE 108 Query: 114 SARGDISLT--------YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAV 165 + + T +FE T A LF +A + + +LEVG+GGRLDATN+V+ ++V Sbjct: 109 TLASALVETKALPWHPSFFEMLTAMAFELFARAGIQIAVLEVGMGGRLDATNVVEPLISV 168 Query: 166 VTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGV 225 + I+LDH +LG I EKAGI + +V P+ P+ DV Q +G+ Sbjct: 169 IADISLDHQKFLGNTIAEIAAEKAGIIKPNG-TVVTLPQHPAA-NDVIGHAILDHQAKGI 226 Query: 226 EWNYSVTDH-------DWAFSDAHGT----LE--------NLPLPLVPQ-PNAATALAA- 264 S H + D G LE N PLP Q N A A+ Sbjct: 227 ----SAVKHMPPMAPGSADYRDVEGRNRYPLEVMNEIIEVNSPLPGRHQLRNLALAITTA 282 Query: 265 --LRASGLEVSENAIRDGIASAILPGRFQIVSESPR-----VIFDVAHNPHAAEYLTGRM 317 L G V+ I GI GRFQ++S +IFDVAHNP A L + Sbjct: 283 EELARFGFPVTSKQIEQGIRETRWAGRFQVISAEKNALKRELIFDVAHNPDGAWALRSAL 342 Query: 318 KALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 + V G +HDK + L + PR AT +L E Sbjct: 343 SDKIAERPLTLVFGAMHDKAFREMVQILFPTAQQVIVTQAKNPRAATTAELAE 395 >UniRef50_Q2GGC6 Folylpolyglutamate synthase n=11 Tax=Rickettsiales RepID=Q2GGC6_EHRCR Length = 435 Score = 157 bits (398), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 124/395 (31%), Positives = 188/395 (47%), Gaps = 33/395 (8%) Query: 46 KPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAH 105 K P V +AGTNGKG+T + IL +AG K +Y+SPHLV + ERV + G+ + + Sbjct: 39 KKLPPVIHIAGTNGKGSTISFIRYILNSAGLKTHIYTSPHLVEFNERVVLAGKRISDQYL 98 Query: 106 TASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAV 165 A I +T+FE T + L F + D+V++E G+GGRLDATN+V + + Sbjct: 99 HEVIEICREASEGIPVTFFEGTTAAILLAFSKVDADIVLVETGVGGRLDATNVVHPILNI 158 Query: 166 VTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADV----AQEKGALLQ 221 +TSI+L+HT+ LG E I EKAGI + ++ P+ +I +V A +K L Sbjct: 159 ITSISLEHTEALGNTVELIAGEKAGIMKENVTCVIA-PQDQESIMNVLEYHAIKKNVPLY 217 Query: 222 RRGVEWNYSVTDHDWAFSDAHGTLENLPLP-------LVPQPNAATALAALRAS-GLEVS 273 R G++W F + L PLP ++ NA A + L G + Sbjct: 218 RGGIDWFCERKGDSMLFKSSVDELL-FPLPSLRGEHQIINAGNAIAACSILSGKFGYNID 276 Query: 274 ENAIRDGIASAILPGRFQIVSES------PR---VIFDVAHNPHAAEYLTGRMKALPKNG 324 I G+ A P R + ++ P+ + D AHNP E L+ R + G Sbjct: 277 YENIVQGLKEAYWPARLEKITTGFLSKMVPQLWDLFLDGAHNPAGGEMLS-RWIQNNELG 335 Query: 325 RVLAVIGMLHDKDIAGTLAWLKSVVD--DWYCAPLEGPRGATAEQLLE---HLG-NGKSF 378 + +IGM +KD A L +LK + C E PR TA +LL+ LG + Sbjct: 336 DLYIIIGMTREKDSAVFLNYLKPYIKFLSSVCIKSE-PRAQTAAELLQTALSLGIKAVAA 394 Query: 379 DSVAQAWDAAM--ADAKAEDTVLVCGSFHTVAHVM 411 ++A A + D + T+L+CGS + V+ Sbjct: 395 KTLADAISKILEVGDCNRKSTILICGSLYLAGDVL 429 >UniRef50_B9JXV9 Folylpolyglutamate synthase n=81 Tax=Alphaproteobacteria RepID=B9JXV9_AGRVS Length = 470 Score = 157 bits (398), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 134/428 (31%), Positives = 208/428 (48%), Gaps = 34/428 (7%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESILMAAG 75 ++ L LH K D+ LER+ + LG + P V VAGTNGKG+ ++L A G Sbjct: 36 INELMQLHPKGFDMTLERMRRLLEVLGNPQDKLPPVIHVAGTNGKGSVSAFSRALLEAGG 95 Query: 76 YKVGVYSSPHLVRYTERVRV-----QGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 V V++SPHLV + ER R+ +GQ + + + + + A +T FE T + Sbjct: 96 LAVHVHTSPHLVNWHERYRIGVKGGKGQIVDDGSLADALRRVAVANAGQHITVFEILTAA 155 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKA 189 A LF + D VI+EVG+GGRLD TN+VD V+V+ I+ DH +LG E I EKA Sbjct: 156 AFLLFSEIPADAVIMEVGMGGRLDCTNVVDRPAVSVIMPISFDHQAYLGDRVELIAAEKA 215 Query: 190 GIFRSEKPAIVGEPEMPS---TIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 GI + +P ++G E + + D+A+ G L G ++ + +H L Sbjct: 216 GIMKRRRPVVIGHQEFAAAREALVDIAERLGCPLSVFGQDY-LAFEEHGRLVYQDESGLM 274 Query: 247 NLPLPLVPQPN----AATALAALRASGLEVSENAIRDGIASAILPGRFQIVSE------S 296 +LPLP +P + AA A+ A+R++G V+E + S PGR Q ++E + Sbjct: 275 DLPLPKLPGRHQFANAAAAIRAVRSAGFTVTEAMAETAMYSVEWPGRLQKLTEGALLAHA 334 Query: 297 PR---VIFDVAHNPHAAEYLTGRMKAL-PKNGRVLAVI-GMLHDKDIAGTLAWLKSVVDD 351 P+ + D HNP A E + M + R L +I GML+ KD G + + Sbjct: 335 PKGAEIWVDGGHNPGAGEVIAEAMAGFEERQSRPLYLITGMLNTKDPLGYFKAFEGLAIQ 394 Query: 352 WYCAPLEGPRG-----ATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDT---VLVCGS 403 + P+ G A A + + SVA+A +A + AE+ +L+ GS Sbjct: 395 AFTVPIRGTDAALDPVALASSAYDAGIPAEPVSSVAEALEAICSRVNAEEIAPRILIGGS 454 Query: 404 FHTVAHVM 411 + V +V+ Sbjct: 455 LYVVGNVL 462 >UniRef50_Q0BWJ9 Putative folylpolyglutamate synthase n=1 Tax=Hyphomonas neptunium ATCC 15444 RepID=Q0BWJ9_HYPNA Length = 417 Score = 157 bits (398), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 130/412 (31%), Positives = 195/412 (47%), Gaps = 31/412 (7%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPA---PFVFTVAGTNGKGTTCRTLESILMA 73 L E L+ TI+L L R+ LG +P P V VAGTNGKG+TC + ++ A Sbjct: 12 LKRFEGLYPDTIELSLGRIEHALDALG--RPQDRLPPVIHVAGTNGKGSTCAFMRAMAEA 69 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALW 133 AG KV V++SPHLVR+ ER+R+ G+ + ++A A G +T+FE T +AL Sbjct: 70 AGLKVHVFTSPHLVRFNERIRLAGKLVEDAALIGWLDRTFEAIGGGQITHFEATTAAALL 129 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F + DV+ILEVGLGG+ DATN++ A ++V+T + DH +LG D I EKAGI Sbjct: 130 AFSEVPADVLILEVGLGGKYDATNVIGAPALSVITPVDYDHAQFLGTDLAGIAAEKAGII 189 Query: 193 RSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 ++ +PA+ + + + I A E GA L R + ++ + + A S H Sbjct: 190 KAGRPALTSIQQDVADAVITARAAEVGAPLYRLKPHFIEAMPE-EVALSGRHQRANAALA 248 Query: 251 PLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP--------RVIFD 302 + Q L + + + AI G A+ P R Q + + P V D Sbjct: 249 AMAMQ---------LFGQSVRIDQAAIFKGAREAVWPARMQRLKDGPVTALAGGLPVWLD 299 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV-VDDWYCAPLEGPR 361 HNPHAA + + L G+ V ML KD AG + V+ + C G + Sbjct: 300 GGHNPHAARAIALHLDGL--GGKTALVSAMLASKDSAGFFVPFAPLGVEVFTCPNAPGHQ 357 Query: 362 GATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAE--DTVLVCGSFHTVAHVM 411 +L + + ++ AM A A D +L+CGS + V+ Sbjct: 358 AMPPAELAQAASRAGLRVTACTSFQDAMRAAAASRPDRLLICGSLYLAGEVL 409 >UniRef50_Q2GD55 Folylpolyglutamate synthase n=2 Tax=Neorickettsia RepID=Q2GD55_NEOSM Length = 442 Score = 157 bits (397), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 123/406 (30%), Positives = 191/406 (47%), Gaps = 34/406 (8%) Query: 28 IDLGLERVSLVAARLGVLK-PAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 IDL L RV+ V RLG P V VAGTNGKG+T L +IL A+GY V VY+SPHL Sbjct: 25 IDLKLHRVTRVLKRLGSPHLSVPPVIHVAGTNGKGSTIAFLRAILQASGYSVNVYTSPHL 84 Query: 87 VRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILE 146 + ER+ ++ +E+ + ++ A LT+FE TL+A+ F ++ D ++E Sbjct: 85 RYFNERIVLRNREISDKFLYDVLEDVRIASQGEKLTFFEGTTLAAILAFSRSNADFSLIE 144 Query: 147 VGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEP-- 203 G+GGRLDATN+ +A ++T+I DHT +LG I EKAGI + P +V Sbjct: 145 TGMGGRLDATNVFPKPIATIITAIDFDHTSYLGATIAQIAYEKAGIIKEGVPCVVARQHG 204 Query: 204 EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLP---------LVP 254 E I VA+ K + R+G EW F +E PLP Sbjct: 205 EAIDIIQGVAKSKRVPVFRQGHEWEVGTDGRMLQFG-VSSHVEEYPLPNLRGLHQIGNAG 263 Query: 255 QPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS-----------ESPRVIFDV 303 AA + + R + +S ++ GI +A P R Q++ E D Sbjct: 264 NAIAAATILSSRYNCDAISVESVSIGIKNADWPARLQLIRGKKNKLVGMLPEGWEFYMDG 323 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-PRG 362 AHNP A+ ++ + + ++ ++GM DKD ++ L ++ ++G PR Sbjct: 324 AHNPSGAKTISEWL----EKEKIHIILGMTRDKDTKEFVSHLLPNIESISVVCVQGEPRS 379 Query: 363 ATAEQLLE---HLG-NGKSFDSVAQAWDAAMADAKAEDTVLVCGSF 404 T E++ + LG + S+ A+ ++ +L+CGS Sbjct: 380 KTIEEIAQPILELGLECRKSSSLEDAFYHILSRDSDSKKILLCGSL 425 >UniRef50_B4UGX6 FolC bifunctional protein n=4 Tax=Anaeromyxobacter RepID=B4UGX6_ANASK Length = 408 Score = 157 bits (396), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 134/352 (38%), Positives = 175/352 (49%), Gaps = 22/352 (6%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 +YL +L + GLER+ LG + V V GTNGKG+TC + L AG + Sbjct: 8 AYLSSLQPLAMRFGLERMERALDALGHPERGYRVLHVGGTNGKGSTCAMAAAALREAGLR 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA--------RGDISLTYFEYGTL 129 G+Y+SPHLVR+ ER++V G E+ ++A A+ + A GD LTYFE TL Sbjct: 68 TGLYTSPHLVRFNERIQVDGVEISDAALAAALEAVRRACPWHEAGGEGD-RLTYFEVATL 126 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 + L A++D ++EVGLGGR DATN + V + I LDHT LG E + EKA Sbjct: 127 AGLLHLADARVDAAVIEVGLGGRFDATNAIRPAVTAIARIGLDHTQLLGDTVERVAFEKA 186 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 GIF+ PA+V P+ +V + + A RRG + V W D L P Sbjct: 187 GIFKPGVPAVV-HAAQPAGALEVLRAEAA---RRGAP--FVVAGEAW---DGPVALRG-P 236 Query: 250 LPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHA 309 AA AL AL +G+ V E+AI GIA A PGR + E V+ D AHNP Sbjct: 237 HQRANAALAAAALRALAGAGVAVPEDAIARGIAGARWPGRLE---ELGGVLLDGAHNPQG 293 Query: 310 AEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 A L + AL V V G+L DKD AG LA L V + PR Sbjct: 294 AAALAAALPALHPGRPVELVFGVLADKDHAGMLAALAPAVRRLHLVTPPSPR 345 >UniRef50_A5CR24 FolC protein n=6 Tax=Actinobacteria (class) RepID=A5CR24_CLAM3 Length = 524 Score = 157 bits (396), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 120/344 (34%), Positives = 173/344 (50%), Gaps = 34/344 (9%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 V GTNGK +T R ESIL AAG + G+++SPHLVR+ ER+ V G + + A + ++A++E Sbjct: 124 VTGTNGKTSTSRMTESILRAAGLRTGLFTSPHLVRFNERIVVDGLPITDEALSRNWADVE 183 Query: 114 S----------ARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADV 163 A G+ +T+FE T+ A F A +DV ++EVG+GG D+TN+ D V Sbjct: 184 PFIDLVDRELVAAGEEPVTFFEALTVLAFAAFADAPVDVAVIEVGMGGEWDSTNVGDGQV 243 Query: 164 AVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPA--IVGEPEMPSTIADVAQEKGALLQ 221 AV T ++LDHT LG I R K+GI KPA +V + P +A++ + A L Sbjct: 244 AVFTPVSLDHTQRLGSTVAEIARTKSGIV---KPAADVVSSAQAPDVVAELV--RAAELT 298 Query: 222 R----------RGVEWNYSVTDHDWAFSDAHGTLENLPLPLVP--QPNAATALAALRASG 269 R ++ +V + GT ++ LP+ Q A A S Sbjct: 299 ESTWSIEGERFRLLDTTLAVGGQVISVQGLAGTYRDVFLPMFGAHQAQNAAVAIAAVESF 358 Query: 270 LEVSENAIRD-----GIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNG 324 L ++AI D G+A+A PGR Q+V P V+ D AHNP A L + Sbjct: 359 LGGCDHAIHDDVLAEGLATATSPGRLQVVGTEPTVLVDAAHNPAGAASLAAALPVYFTFD 418 Query: 325 RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 RV AVIG+L DKD G + L VVD + + R ++L Sbjct: 419 RVTAVIGVLADKDAEGIVRELAPVVDHFIVTRSQSERSVDPDEL 462 >UniRef50_Q1MS38 Folylpolyglutamate synthase n=1 Tax=Lawsonia intracellularis PHE/MN1-00 RepID=Q1MS38_LAWIP Length = 435 Score = 156 bits (395), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 116/320 (36%), Positives = 168/320 (52%), Gaps = 23/320 (7%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCRTLESILMAAGY 76 ++L+NL IDL L R++ +L P+ V + GTNGKG+T L S+ + G Sbjct: 11 NFLDNLGLFNIDLELTRMNQALTKLD-FNSLPYKVVQIVGTNGKGSTATFLASLAKSHGL 69 Query: 77 KVGVYSSPHLVRYTERVRVQGQEL-PESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 KVG+Y+SPH V ER+ + G+ L PE T + +++ +SLTYFE T+ A+ F Sbjct: 70 KVGIYTSPHFVTPRERICINGEMLSPEVWITLTERILDNT---LSLTYFELLTVLAIVAF 126 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 + ++D+ ILE GLGG+ DAT V AD+ T I LDH +LG E+I +EK+ R Sbjct: 127 SEFKVDLAILEAGLGGQHDATTAVPADLVCYTPIDLDHEQFLGSTVEAIAKEKSQAMRFR 186 Query: 196 KPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL-ENLPLPL 252 KP + +PE+ S + +A+EK Q +E V D + D T E L L + Sbjct: 187 KPVLSSFQQPEVMSILCAMAKEKNCSFQ--SLEQISLVYDLFYPNLDGSQTKSEYLTLGM 244 Query: 253 V---PQPNAATALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSESPRV-----I 300 + NA ALAA + G + + N I G+A A +PGRFQ V +P + I Sbjct: 245 AGKHQRVNAQLALAAWHVLSQNFGWDFNLNCIYKGLAHAFIPGRFQYVPPNPSLGCLPTI 304 Query: 301 FDVAHNPHAAEYLTGRMKAL 320 D AHNPH E K++ Sbjct: 305 LDGAHNPHGLEACIAACKSI 324 >UniRef50_B6IV82 FolC bifunctional protein n=5 Tax=Alphaproteobacteria RepID=B6IV82_RHOCS Length = 436 Score = 156 bits (395), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 119/332 (35%), Positives = 170/332 (51%), Gaps = 22/332 (6%) Query: 2 IIKRTPQAASP-LASWLSYLENLHSKTIDLGLERVSLVAARLG-VLKPAPFVFTVAGTNG 59 +IK T A+P L + L L LH K IDL L RV + ARLG + P + VAGTNG Sbjct: 1 MIKATVVPAAPRLEAALDRLRLLHPKVIDLSLGRVERLLARLGNPERRLPPLVHVAGTNG 60 Query: 60 KGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI 119 KG+T L ++L AAG +V VY+SPHLV + ER+R+ G+ + + A + E A GD Sbjct: 61 KGSTVAFLRAMLEAAGARVHVYTSPHLVHFNERIRLAGRLIGDEALAGLLEDCERANGDD 120 Query: 120 SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLG 178 +T+FE T +A F D+ +LEVGLGGRLDATN+++ V+++T I++DH +LG Sbjct: 121 PVTFFEITTAAAFRAFADVPADICLLEVGLGGRLDATNVIERPAVSLLTRISMDHMQFLG 180 Query: 179 PDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEK----GALLQRRGVEWNYSVTDH 234 I EKAGI + PA+ G P+ + V +E+ G L+ G W D Sbjct: 181 STLAEIAWEKAGILKPGAPAVAG-PQADPVVLHVFRERAADLGVPLRSYGESWTARPRDG 239 Query: 235 DWAFSDAHGTLENLPLPLVPQPNAATALAALRASG----LEVSENAIRDGIASAILPGRF 290 + F +L +LPLP +P + A+ + V + A R+G+ P R Sbjct: 240 GFRFESPARSL-DLPLPGLPGAHQILNAGLALAALEHLPVAVDDGAAREGMRRVEWPARL 298 Query: 291 QIVSESP---------RVIFDVAHNPHAAEYL 313 Q + P + D HN A E L Sbjct: 299 QRLHRGPLTEALPPGWELWLDGGHNDSAGEVL 330 >UniRef50_Q02Z16 Folylpolyglutamate synthase n=20 Tax=Bacteria RepID=Q02Z16_LACLS Length = 427 Score = 156 bits (395), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 125/426 (29%), Positives = 207/426 (48%), Gaps = 32/426 (7%) Query: 20 LENLHSK---TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 LE +HS+ I GL RVS + LG + + + +AGTNGKG+T SI M AG Sbjct: 7 LEWIHSRLKFNIRPGLNRVSALLELLGNPEESLSMIHIAGTNGKGSTVAFTRSIFMQAGL 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI----ESARGDISLT---YFEYGTL 129 KV ++SP + + ER+ + Q +P+ I E D LT FE T Sbjct: 67 KVASFTSPFITTFGERMSINAQPIPDEKLIYYVKMIQPLVEKLDNDAELTGITEFEIITA 126 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 A F ++D+ ++EVGLGG LD+TN++ V+ +T+I LDH D LG E I +KA Sbjct: 127 MAFKYFADEKVDLAVIEVGLGGLLDSTNVIRPVVSGITTIGLDHIDILGSTIEEIAAQKA 186 Query: 190 GIFRSEKPAIVGEPEMPS--TIADVAQEKGALLQRRGVEWNYSVTDHD----WAFSDAHG 243 GI ++ P +VG E+ + I +VA++ A + + ++ + +H+ +A +A Sbjct: 187 GIIKAGIPVVVGNIELKALRVIWEVARKNTARIYQYPYDYRTELKEHEHFDFFASQEAIL 246 Query: 244 TLENLPLPLVPQPNAATA--LAALRAS--GLEVSENAIRDGIASAILPGRFQIVSESPRV 299 LE + L NA A LA + A+ G+ ++E IR GI A P R + + E+P + Sbjct: 247 DLEKSLIGLHQVENAGMAIELALVYANKVGINLNEEIIRAGIREAFWPARMEKLGENPLI 306 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD-WYCAPLE 358 + D AHN HA L + + ++ + + KDI + L++V + + Sbjct: 307 LLDGAHNVHAMNRLLENLGKEFPDKKITIIFSAITTKDIRQMIKMLQTVKNSRLILTTFD 366 Query: 359 GPRGATAEQL--LEHLGNGKSFDSVAQAWDAAMADAKA----EDTVLVCGSFHTVAHVME 412 P+ + LE G +A +W+ A+ A+ ++ +L+ GS + + V E Sbjct: 367 YPKALDLKDFRYLEDEGV-----ELAPSWELAIVRAQKALNEDELLLITGSLYFSSQVRE 421 Query: 413 VIDARR 418 + + Sbjct: 422 FLKKEK 427 >UniRef50_C8X0V4 FolC bifunctional protein n=1 Tax=Desulfohalobium retbaense DSM 5692 RepID=C8X0V4_DESRD Length = 413 Score = 156 bits (395), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 138/408 (33%), Positives = 185/408 (45%), Gaps = 18/408 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 S A++ +++ L +DL LER+ V L +P V GTNGKG+T LE + Sbjct: 5 SSFAAFEAHVNTLGLFHMDLRLERMDRVLTCLERTRPQGLTLQVLGTNGKGSTSSMLEGL 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 A G + GV+SSPH V ERVR+ G L E + + + D LTYFE+ T Sbjct: 65 ARAQGRRTGVFSSPHFVSLRERVRIDGALLDEQQWLRAANSVAAC--DPELTYFEWMTAV 122 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 AL LF +DV+ILE GLGGR DAT V D VVT I DH + LGP E I +KAG Sbjct: 123 ALELFAIHDVDVLILEAGLGGRHDATTAVAVDGTVVTPIGEDHENILGPGLERIAADKAG 182 Query: 191 IFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 FR P E+ + + A++ + L R V + GT + Sbjct: 183 AFRPGVPVFSARQSAEVRNVLEGAAEKCRSPL--RFVPSDPPCDVPSCLAERLPGTHQQD 240 Query: 249 PLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP-RVIFDVAHNP 307 L +A A + G E S +R G A LPGR Q V+ D AHN Sbjct: 241 NFRLATLAWSACA----KQLGAETSPAILRRGAQLAWLPGRLQWCRLGELEVLLDGAHNL 296 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD--WYCAPLEGPRGATA 365 A E L ++AL R L + L DK AG L ++ D W GPR A Sbjct: 297 PALECLQQFVEALEAPPRQL-IFSCLSDKATAGLLEQIRQFNMDAVWVPEIAAGPRNLPA 355 Query: 366 EQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 QL +G G + ++ A A +A VL+CGS + +A + Sbjct: 356 RQLASQVG-GTAVATLGHALQCAQ---EAGGRVLICGSLYLLAEFFRL 399 >UniRef50_C6LLD0 Tetrahydrofolate synthase n=3 Tax=Clostridiales RepID=C6LLD0_9FIRM Length = 437 Score = 156 bits (394), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 127/408 (31%), Positives = 195/408 (47%), Gaps = 29/408 (7%) Query: 30 LGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRY 89 LGLE + + + LG + +AGTNGKG+ + +IL AGY+VG Y SP L Y Sbjct: 23 LGLEAMRALLSELGDPQDKLKFIHIAGTNGKGSVLAYVSTILKEAGYRVGRYISPTLFSY 82 Query: 90 TERVRVQGQELPESAHTASFAEIESARGDISL------TYFEYGTLSALWLFKQAQLDVV 143 ER++V + + A T + A G + T FE T A F Q D+V Sbjct: 83 RERIQVNEIYITKEALTEHTFRVREAVGRMKAAGNPLPTVFEIETAIAFLYFVQEDCDIV 142 Query: 144 ILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG- 201 +LE G+GG DATN V V ++TSI++DH +LG I KAGI + + + Sbjct: 143 VLETGMGGDTDATNAVQTTVLEILTSISMDHMQFLGNSLAEIAAHKAGIIKPDTVVVSAA 202 Query: 202 -EPEMPSTIADVAQEKGALLQ----RRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV--- 253 EPE I ++A + A L+ R E Y + +A + G +NL + L Sbjct: 203 QEPEAMRVIEEIAAGQRAQLRIADAGRAEEVAYGL----FAQRFSCGGYKNLEIRLAGTY 258 Query: 254 ---PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 A A+ AL+ G ++E +R G+A + GRF ++ + P I D AHN AA Sbjct: 259 QIANAVVAVEAVRALQELGFRITEEQLRQGLAKTVWRGRFTVICDEPLFIVDGAHNRGAA 318 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQLL 369 E L +K R++AV G+L DK+ L +D + PR AE+L Sbjct: 319 EQLRESIKTYLAGRRIIAVCGVLKDKEYEAVLQITAPYIDRMITIETPDNPRALPAEELA 378 Query: 370 ----EHLGNGKSFDSVAQAWDAAMADAKAE-DTVLVCGSFHTVAHVME 412 +++ + ++ +S+AQA D + + A E D +L GS + +++ Sbjct: 379 RTAQKYIPHVEAAESLAQAVDRSFSAADREGDVILAFGSLSYLGEMIK 426 >UniRef50_A8RF48 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM 3991 RepID=A8RF48_9FIRM Length = 405 Score = 156 bits (394), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 113/364 (31%), Positives = 179/364 (49%), Gaps = 16/364 (4%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 V GTNGKG+T + +IL AAGY+VG ++SP+L+ + +R+R+ E+ E+ + Sbjct: 44 VGGTNGKGSTTNYVRAILQAAGYRVGSFTSPYLITHRDRIRINDIEISEADFLKIANDYY 103 Query: 114 SARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDH 173 ++ + L+ FE A FKQ ++D + EVGLGGRLDATN++ ++V+T+I +DH Sbjct: 104 ASWIEWDLSMFEIDMCIASVYFKQQKVDYCVFEVGLGGRLDATNVLQPLLSVITNIGMDH 163 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSV 231 ++ LG +I +EKAGI + P + E E S A++A+EK + + N Sbjct: 164 SELLGDSYTAIAKEKAGIIKEGIPLVTAEKKAECCSVFAEIAKEKHSEVHVLKPIENRRC 223 Query: 232 TDHDWAFSDAHGTLENLPLPLVPQ---PNAATALAA--LRASGLEVSENAIRDGIASAIL 286 + F +G + + L NAA A+ A L L +SE +R +A+ Sbjct: 224 ENLHILFD--YGDHKQIKLATAADYQCENAALAIEAVSLLHGRLHISEEILRQALAATQW 281 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 GRF+IV + P VI D AHN E L + + + V +L DK+ L L Sbjct: 282 KGRFEIVQKEPLVILDGAHNVEGIEALCDSLDNIHNP---VIVFSVLKDKNFTVMLEKLM 338 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 + D L R ++L + DS A A A +A V++ GS + Sbjct: 339 GITDTMIVTKLHHERAYDMDRLAQQYDVCYIEDS-KTAIQQACAMKRA---VVITGSLYF 394 Query: 407 VAHV 410 ++ V Sbjct: 395 ISEV 398 >UniRef50_Q3ZAH8 Folylpolyglutamate synthetase n=5 Tax=Dehalococcoides RepID=Q3ZAH8_DEHE1 Length = 439 Score = 155 bits (393), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 126/401 (31%), Positives = 193/401 (48%), Gaps = 40/401 (9%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESA------HTA 107 +AGT GKG+T + S++ AAGY+ G+Y+SPHL+ + ER+R+ G+ + ++ + + Sbjct: 41 LAGTKGKGSTAALIASVMSAAGYRTGLYTSPHLLDFRERIRLDGKMISKAHLVRIMDYIS 100 Query: 108 SFAEIESARGDI-SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVV 166 E +AR + +T FE T+ A F + Q ++E GLGGRLDATN++ +++V+ Sbjct: 101 PMVEEMNARTCLGKITSFEVMTVLAFEFFHRQQAFFQVIETGLGGRLDATNVITPNLSVL 160 Query: 167 TSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALL---- 220 T I+LDHT+ LG I EKAGI + P + PE + I + + G+ L Sbjct: 161 TPISLDHTEVLGDSLAKISAEKAGIIKHFVPVVSAAQRPEAMAVIRERCLKTGSKLIEVT 220 Query: 221 -QRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV---PQPNAATALAALRA---SGLEVS 273 + Y+ S L LPL+ + NA TALA+L A G ++S Sbjct: 221 DSYKAELLGYTAQGQSLKLSGRQAEY-RLCLPLLGHYQRQNALTALASLEALVEEGFKIS 279 Query: 274 ENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRV-----LA 328 I +G PGRF+++ P ++ D AHN AA L ++ P +V L Sbjct: 280 NEDIAEGFGQVRWPGRFKVIKGKPLMVIDGAHNQEAAAELLLSLQEYPPAAKVEKEKRLL 339 Query: 329 VIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG----PRGATAEQLLEHLGNGKSF-----D 379 V G DKD AG +A V+ ++ + PR A LL +G+ D Sbjct: 340 VFGTSFDKD-AGAMA---DVLSGYFGTVILTHSLHPR-AMKPDLLRKAFDGRGLKVLEAD 394 Query: 380 SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSG 420 V +A + A A A+ V V GS A ++ RSG Sbjct: 395 GVPKALELAGRIAPADGLVCVAGSLFVAAEALKGQSQPRSG 435 >UniRef50_A5N275 FolC n=22 Tax=Clostridium RepID=A5N275_CLOK5 Length = 450 Score = 155 bits (392), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 115/441 (26%), Positives = 207/441 (46%), Gaps = 39/441 (8%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L Y+ N+ ++LGLER + LG VAGTNGKG+ + +LM AG+ Sbjct: 7 LQYINNIAKFGVNLGLERTEKILELLGNPHKKIKAVHVAGTNGKGSITVMISRVLMEAGF 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYGTLS 130 KVG+Y+SP+L ++ ER+++ G+ + + ++ A + + T FE T + Sbjct: 67 KVGMYTSPYLEKFEERIQINGKNISHDDLSRVVTKVSKAVDKVLQLGYDNPTEFEVITCA 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIV---------DADVAVVTSIALDHTDWLGPDR 181 + F + ++++ ++EVGLGGR D+TN++ +V+ SI+ DH + LG Sbjct: 127 MFYYFWEKKVEIAVIEVGLGGRFDSTNVMVSFAKECEGGVMASVIASISYDHMNILGDTL 186 Query: 182 ESIGREKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH----- 234 E I EKAGI + P I+ + I V +EKG+ L + V + + + Sbjct: 187 EKIAYEKAGIIKKGIPVILYPQSESVEKVIEKVCEEKGSELLKVPVNSSNLIGGNKIDSG 246 Query: 235 --DWAFSDAHGTLE---NLPLPLVPQP---NAATALAALRA---SGLEVSENAIRDGIAS 283 ++ T E ++ L L+ + N A AL L + V ++ I + + Sbjct: 247 SREYVQQVKIATKEADYDIKLSLLGKHQLLNCAAALFTLEQLSRYDILVDKSVISRALGN 306 Query: 284 AILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA 343 GR +++ +P V+ D AHN L + + ++ ++G+L DK++ + Sbjct: 307 VSWKGRLEVMGRNPLVVIDGAHNIQGISMLKENICRYFQYNDMILILGILADKEVEKMVK 366 Query: 344 WLKSVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVL 399 + + + RG A +L +G N + F+ +A+ A++ ED +L Sbjct: 367 TIVPLAKRVMAVTPKDKRGQIAGRLKTIIGKYNSNCEDFNDYEKAYRKALSYCSKEDLIL 426 Query: 400 VCGSFHTVAHVMEVIDARRSG 420 VCGS + V + ++I +R G Sbjct: 427 VCGSLYMVGDMRKII--KRHG 445 >UniRef50_C6VI65 Folylpolyglutamate synthase n=8 Tax=Bacilli RepID=C6VI65_LACPJ Length = 444 Score = 155 bits (392), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 119/388 (30%), Positives = 188/388 (48%), Gaps = 33/388 (8%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 VAGTNGKG+T L + MA G VG ++SP +VR+ ER+ V G + + +I+ Sbjct: 46 VAGTNGKGSTVANLRELFMADGLTVGTFTSPFIVRFNERISVDGTPISDEELVGLVQQIQ 105 Query: 114 S--ARGDISL-----TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVV 166 A+ D +L T FE T F +D+ I+EVGLGG D+TN+ V+V+ Sbjct: 106 PIVAKLDATLASGGPTEFEIITAMMFLYFAAQPIDIAIIEVGLGGLYDSTNVWTPAVSVI 165 Query: 167 TSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRG 224 T+I DH LG +I +KAGI +++ P IVG+ E + D A K A L+ G Sbjct: 166 TTIGYDHMQILGNTLTAIATQKAGIIKTQVPVIVGKLPAEAQQVMIDTAMSKRAPLRTLG 225 Query: 225 VEWNYSVT-----DHDWAFSDAHGTLENLPLPLVPQ---PNAATALAAL----RASGLEV 272 V++ + + F ++L PL+ NAA A+AA +A+ L V Sbjct: 226 VDFTTKLLPPQGWQERFNFDGLEAHFKDLTTPLLGDYQVDNAAVAIAAYLTYHQATQLPV 285 Query: 273 SENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGM 332 + ++ +A+ PGRF+ +++ P ++ D AHN A L + V + + Sbjct: 286 VTSDVKAAVAATQWPGRFERLNQDPLIMIDGAHNEPAVTELAATLSERFGQQTVYVIFAV 345 Query: 333 LHDK---DIAGTLAWLKSVVDDWYCAPLEGP---RGATAEQLLEH-LGNGKS---FDSVA 382 L DK + TL L +V EGP R AT +L H + NG++ FD+ Sbjct: 346 LADKQHQQMIQTLGALPNV--QLRLTQFEGPNAKRPATDPTMLAHEMPNGRTAEVFDNWQ 403 Query: 383 QAWDAAMADAKAEDTVLVCGSFHTVAHV 410 A + + ++D +L+ GS + ++ V Sbjct: 404 AALMQTLQEMSSDDALLLTGSLYFISDV 431 >UniRef50_A5FWT1 FolC bifunctional protein n=1 Tax=Acidiphilium cryptum JF-5 RepID=A5FWT1_ACICJ Length = 437 Score = 155 bits (391), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 124/385 (32%), Positives = 182/385 (47%), Gaps = 31/385 (8%) Query: 49 PFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTAS 108 P VAGTNGKG+ C L ++ AAG + VY+SPHLVR+ ER+R+ G + + A+ Sbjct: 52 PPTIHVAGTNGKGSVCAFLRGMVEAAGLRAHVYTSPHLVRFNERIRLAGALVSDDELDAA 111 Query: 109 FAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNI-VDADVAVVT 167 E+E +T FE T +A LF ++ I+EVGLGG DATN+ A +T Sbjct: 112 LDEVERVNDAAPITVFEAITAAAFVLFAARSAEIAIIEVGLGGTFDATNVIPPPAAAAIT 171 Query: 168 SIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGV 225 +I+LDH ++LG I EKAGI + A+ G P++ + + A+ G L RG Sbjct: 172 AISLDHREFLGETETVIAAEKAGIMKPGSRAVTGFQTPDVLAVLESRAKAAGVPLAARGR 231 Query: 226 EWNYSVTDHDWAFSDAHGTLENLPLPLVPQP----NAATALAALRASGLEVSENAIRDGI 281 +W + D G LE LP P +P NA A+AALRA G + ++A G+ Sbjct: 232 QWRIMKQGEGAVYEDEEGRLE-LPRPALPGAHQFDNAGIAIAALRAGGFGLDQDAFARGM 290 Query: 282 ASAILPGRFQ--------IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGML 333 A+A P R Q ++ + D AHNP A+ L + G V+GM Sbjct: 291 AAAEWPARLQRLGPPLASLLPAGSELWLDGAHNPGGAQALAEVLAGW--EGPTHLVVGMK 348 Query: 334 HDKDIAGTL-------AWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWD 386 KD+A L A +++VV+ L E ++E G + +A Sbjct: 349 QAKDVAEFLRILLPQAASVQAVVEPGQHLAL------PVEAIIEASGGVATAGPDVEAAL 402 Query: 387 AAMADAKAEDTVLVCGSFHTVAHVM 411 +A VLVCGS + ++ Sbjct: 403 RRLAADGTPKRVLVCGSLYLAGVIL 427 >UniRef50_C0W165 Possible tetrahydrofolate synthase n=1 Tax=Actinomyces coleocanis DSM 15436 RepID=C0W165_9ACTO Length = 528 Score = 155 bits (391), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 112/389 (28%), Positives = 191/389 (49%), Gaps = 26/389 (6%) Query: 8 QAASPLASWLSYLENLHSKT----IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTT 63 +AA A +L+ E + ++T + L+R+ + LG + + V GTNGK +T Sbjct: 82 EAAQVEADYLALQEAILTRTPEHKFEPTLDRMLMAFNLLGDPQLSYRSVHVTGTNGKTST 141 Query: 64 CRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI---- 119 R + ++L A+G KVG Y+SPHL ER+ V + + E ++A++ G + Sbjct: 142 SRMISALLQASGRKVGRYTSPHLTSMKERICVNEEPISERQFLEAYADVAPYIGMVDELG 201 Query: 120 ------SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDH 173 +++FE T++ L F +D ++EVG+GG DATN+++A+VAV T I +DH Sbjct: 202 RRNNGPQMSFFEVFTVTGLAAFADIPVDAAVVEVGIGGEWDATNVINAEVAVFTPIGVDH 261 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY-- 229 +LGP ES R K+GI + A+ EPE+ + + A E GA+++ G E Sbjct: 262 EAYLGPTAESAARIKSGIMKPGAIAVSAPQEPEVEAVLRAKAAEVGAVIRFIGQEVQLLD 321 Query: 230 ---SVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS-----GLEVSENAIRDGI 281 +V + +++ +PL + A A AL A G + + + +G Sbjct: 322 RKVAVGGQVITVQTSAAVYQDIFVPLHGEHQAQNATLALAALEAFNGGRALEDRIVEEGF 381 Query: 282 ASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGT 341 A + PGR ++V SP ++ D AHNPH A L ++ ++ V + DK + Sbjct: 382 AMSTSPGRLEVVRTSPSILVDAAHNPHGASALAAALQESFDYSHIVGVYSAMADKQVEAV 441 Query: 342 LAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 LA ++ ++D+ + R E+L E Sbjct: 442 LAEMEPILDEIVITGMNSARAMDVEELAE 470 >UniRef50_A5VL10 FolC bifunctional protein n=8 Tax=Lactobacillus RepID=A5VL10_LACRD Length = 419 Score = 155 bits (391), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 121/394 (30%), Positives = 191/394 (48%), Gaps = 17/394 (4%) Query: 38 VAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQG 97 + RLG + +AGTNGKG+T LE L AGY+VG +SSP LV E+++V Sbjct: 29 ILTRLGNPDQRFKIIHIAGTNGKGSTGTMLEQGLQNAGYRVGYFSSPALVDDREQIKVND 88 Query: 98 QELPESAHTASFAEI-ESARGDI---SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRL 153 + + ++ +I E D+ +T FE+ TL L F ++D ++E GLGG+ Sbjct: 89 HLISKKDFAMTYQKITEHLPADLLPDDITIFEWWTLIMLQYFADQKVDWAVIECGLGGQD 148 Query: 154 DATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADV 212 DATNI+ A ++V+T IALDHT LGP I + KAGI ++ + P + Sbjct: 149 DATNIISAPFISVITHIALDHTRILGPTIAKIAQAKAGIIKTGTKQVFLAPHQEKDALTI 208 Query: 213 AQEKGALLQRRGVEW--NYSVTDHDWAFSDAHGTLENLPLPLV---PQPNAATALAA--- 264 +EK A Q+ G+ S+ D H + +P L+ N T ++ Sbjct: 209 IREK-AQQQKVGLTQADAQSIVDGKAILKVNH-KIYKVPFNLLGTFQSENLGTVVSVFNF 266 Query: 265 LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNG 324 L L S + +A+ + GR Q +++ P +I D AHNP AA+ LT + LP N Sbjct: 267 LYQRRLVTSWQPLLSTLATVKIAGRMQKIADHPPIILDGAHNPDAAKQLTKTISKLPHN- 325 Query: 325 RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP-RGATAEQLLEHLGNGKSFDSVAQ 383 +V+ V+G L DK+I+ + + + D+ + P R A L L ++ Q Sbjct: 326 KVIMVLGFLADKNISQMVKIYQQMADEIIITTPDHPTRALDASALKSVLPQAIIANNPRQ 385 Query: 384 AWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 A A+ D ++V GSF+T+ + +D + Sbjct: 386 GLVVAKKIAEPNDLIIVTGSFYTIKDIEANLDEK 419 >UniRef50_C7MB66 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Brachybacterium faecium DSM 4810 RepID=C7MB66_BRAFD Length = 462 Score = 154 bits (390), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 140/448 (31%), Positives = 202/448 (45%), Gaps = 40/448 (8%) Query: 6 TPQAASP--LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTT 63 +PQA SP + + LE I+ L R++ V +G + + +AGTNGK TT Sbjct: 10 SPQAMSPELREVYAALLERAPENRIEPDLSRITRVMELMGDPQNSYRSIRIAGTNGKTTT 69 Query: 64 CRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAH------TASFAEI----E 113 R LE IL AG + G +SPHL ER+ + G + E A FA I + Sbjct: 70 ARILERILREAGLRTGRTTSPHLRSPVERIAIDGASIDEEGFLQAYHDVAPFAAIVDAEQ 129 Query: 114 SARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDH 173 A G + LTYFEY T A F A +DV ++E GLGG DAT V DVAV+T I+LDH Sbjct: 130 EAAGGVPLTYFEYLTAMAFQAFASAPVDVAVIETGLGGTWDATGAVHPDVAVITPISLDH 189 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEK-GALLQRRGVE-WNYSV 231 D+LG I EKAGI +E AI+ ADV +E+ G L VE V Sbjct: 190 QDYLGDTIAEIAAEKAGILTAEATAILASQPYEDA-ADVLRERIGELGAEAAVEDQQIGV 248 Query: 232 TDHD-------WAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDG---- 280 H + G E + L L+ + A AL A+ A+ + + G Sbjct: 249 LSHTPGVGGQMLSLQGIAGRYEEVFLSLLGEHQARNALLAVAAAEALLGDGRTPLGGELL 308 Query: 281 ---IASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKD 337 ++S PGR ++V ++P ++ D AHNP A L ++ + R + ++G+L +KD Sbjct: 309 SAALSSVTSPGRAEVVRQAPTILLDAAHNPAGALTLVETVRENFRFTRTVGLVGILREKD 368 Query: 338 IAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEH-----------LGNGKSFDSVAQAWD 386 A L L+ ++D PR + L + + D++ A D Sbjct: 369 AAEILDVLEPLLDSVVITQSSSPRAIPTDVLADIARDIFQDEDRVVERASLPDAIQAAVD 428 Query: 387 AAMADAKAEDTVLVCGSFHTVAHVMEVI 414 A D V+V GS V E++ Sbjct: 429 LAETDGDQFGGVVVAGSVTLTGEVRELL 456 >UniRef50_B1HVC8 Folylpolyglutamate synthase n=2 Tax=Bacillaceae RepID=B1HVC8_LYSSC Length = 426 Score = 154 bits (390), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 113/388 (29%), Positives = 188/388 (48%), Gaps = 34/388 (8%) Query: 51 VFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFA 110 V VAG+NGKG+T L +L AGY+VG ++SPHL R ER+ + G+ + + F Sbjct: 40 VIHVAGSNGKGSTVNALREMLQHAGYQVGAFTSPHLERVNERMTINGEPITDEQFLYYFN 99 Query: 111 EI-----ESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAV 165 ++ E GD ++FE TL F +D+ ++E GLGGRLDATN+V +A+ Sbjct: 100 KLAKIIEEQYNGDFP-SFFEVVTLVMFQFFADQGIDIALIETGLGGRLDATNVVSPLLAI 158 Query: 166 VTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTI---ADVAQEKGALL 220 +T+I+L+HT +LG + EKAGI + P ++G E + I AD Q + +L Sbjct: 159 ITTISLEHTAFLGDTFAKVASEKAGIIKKGVPVVIGVSNEEALAVIKQTADAQQAQCFIL 218 Query: 221 QRRGVEWNYSVTD-------HDWAFSDAHGTLENLPLPLV--PQPN----AATALAALRA 267 + +++V+D + + ++ + ++ L + Q N A TA+ ALR Sbjct: 219 GQ-----DFTVSDILQGTDVQQFTYEKSNIVMTDIALKMAGPHQINNAILAITAILALRE 273 Query: 268 SG-LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRV 326 G + +S+ +IR G+ A GRF+ +++ D AHN L +K + Sbjct: 274 EGAITLSDQSIRHGLLYAHWAGRFE--QWPQKIVLDGAHNSEGTAALIQTLKNVFPKSHY 331 Query: 327 LAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL--LEHLGNGKSFDSVAQA 384 V L DKD A ++A + V + P A+ L L N + ++ Sbjct: 332 RFVYAALADKDHANSIALMDDVATSITFTQINLPNAMPAKDLSILSTNANKSYHEDWMES 391 Query: 385 WDAAMADAKAEDTVLVCGSFHTVAHVME 412 + + ED V++ GS + +A+V + Sbjct: 392 VQTVLRERAEEDVVVITGSLYFIANVRQ 419 >UniRef50_C0EVS7 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EVS7_9FIRM Length = 435 Score = 154 bits (390), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 127/427 (29%), Positives = 195/427 (45%), Gaps = 40/427 (9%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 +++S +E L + GL+ + + LG + + +AGTNGKG+ L SILMAA Sbjct: 2 NYISLIEELKKRGSIPGLDAIQGLLEELGHPEDDLKIVHIAGTNGKGSVFAYLSSILMAA 61 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA----RGDISL--TYFEYGT 128 G+KVG Y SP + Y ER ++ G + + + +E A I L T FE T Sbjct: 62 GFKVGRYISPTISCYEERFQINGTYIAKDKLERLYGVVEEAMRKEEAKIGLRPTLFEVET 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGRE 187 + FK+ ++D ++EVG+GGRLDATN++ ++ V++SI+ DH LG E I + Sbjct: 122 ALSFLYFKEEKVDYALVEVGMGGRLDATNVIKHPELTVISSISYDHKAILGDTLEEIACQ 181 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVE---WNYSV---TDHDWAFSDA 241 KAGI + P ++ E P + V + + A + +E +Y + T + F Sbjct: 182 KAGIIKESAPVVLSEN--PEEVCKVVKHEAAEKKVHCIEVKPQDYEILAETPYGSTFLWK 239 Query: 242 HGTLENLPLPLVPQ-PNAATALAA---LRASGLEVSE---------------NAIRDGIA 282 E LP Q NA TAL A L E +E A + GI Sbjct: 240 EQRYET-KLPGNHQISNAVTALTASEYLFEKDYEKNEARKKIPKELDTMNIKAAQQGGII 298 Query: 283 SAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTL 342 I PGR +++ + P D AHNP A L ++ N R++ ++G+L DK+ L Sbjct: 299 RTIWPGRLEVLKKEPLFYRDGAHNPDGARKLASFLQKHFTNKRIIYIMGVLKDKEYTKIL 358 Query: 343 AWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSF-----DSVAQAWDAAMADAKAEDT 397 +L + Y RG +AE L + V A A+ A+ ED Sbjct: 359 QYLMPMAKKVYVFRPNNERGLSAEILANTIKEKADVPVMIEPDVNTAVSKALEAAQPEDI 418 Query: 398 VLVCGSF 404 ++ CGS Sbjct: 419 LVACGSL 425 >UniRef50_D1AAV2 FolC bifunctional protein n=1 Tax=Thermomonospora curvata DSM 43183 RepID=D1AAV2_THECD Length = 471 Score = 154 bits (390), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 140/458 (30%), Positives = 204/458 (44%), Gaps = 78/458 (17%) Query: 28 IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLV 87 D L+R++ + LG + A V V GTNGK +T R +E++L G + G+ +SPHL Sbjct: 25 FDPTLDRIADLMDLLGRPQDAYPVIHVTGTNGKSSTARMIETLLRERGLRTGLSTSPHLT 84 Query: 88 RYTERVRVQGQELPESAHTASFA------EIESARGDISLTYFEYGTLSALWLFKQAQLD 141 ER+ V G+ + E A A++ E+ A+ + L+YFE T A +F A +D Sbjct: 85 TMRERIVVDGEPISEEAFVAAYRDVAPYLEMVDAKHERPLSYFETLTAMAYAVFADAPVD 144 Query: 142 VVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG 201 V ++EVG+GG DATN+ D V+VVT I+LDH LGP E I EKAGI + A++ Sbjct: 145 VAVIEVGMGGVWDATNVADGTVSVVTPISLDHLRHLGPTIEDIAAEKAGIIKPGAIAVLA 204 Query: 202 EPEMPSTIADVAQ-------EKGALLQRRGVEW-----NYSVTDHDWAFSDAHGTLENLP 249 + ++P VAQ E GA R G+E+ + +V HG E + Sbjct: 205 QQQLP-----VAQVLLRRVVEVGATAAREGMEFGVLGRDLAVGGQQLRLQGLHGVYEEIF 259 Query: 250 LPLV----------------------PQPNAATALAALRASGLEVSEN--------AIRD 279 LPL P AA R + E E +R Sbjct: 260 LPLFGSHQAGNAACALAAVEAFASGAPSRTGGDLSAATRIAAGEDFEGDHGQLDPALVRS 319 Query: 280 GIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKN---GRVLAVIGMLHDK 336 A PGR +I P V+ D AHNP ++ + A+ ++ R++ V+ DK Sbjct: 320 AFAKVTSPGRLEIARTGPTVLIDSAHNPAG---MSATVNAITEDFGFTRLIGVVAAAGDK 376 Query: 337 DIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNG-------KSFDSVAQAWDAAM 389 D+AG L L+ V+ + R QL E L G D + A D A+ Sbjct: 377 DVAGMLEQLEPVLTELIVTRNTSHRSMPPRQLGE-LAEGIFGAERVHVIDRLDDAIDRAV 435 Query: 390 ADAKAEDT-------VLVCGSFHTV--AHVMEVIDARR 418 A AE+T VL+ GS T A + ++ RR Sbjct: 436 --ALAEETGEYQGAGVLITGSVVTAGEARTLLRVEERR 471 >UniRef50_A0LA36 FolC bifunctional protein n=2 Tax=cellular organisms RepID=A0LA36_MAGSM Length = 426 Score = 154 bits (390), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 123/390 (31%), Positives = 189/390 (48%), Gaps = 36/390 (9%) Query: 51 VFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFA 110 V VAGTNGKG+ +IL AG V Y+SPHLV ER++ G + ++ Sbjct: 47 VVHVAGTNGKGSVIAFFGAILRQAGRSVAAYTSPHLVTIHERIQYNGVPVEDALLRYYAQ 106 Query: 111 EIESARGDISLTYFEYGTLSALWLFKQAQLD----VVILEVGLGGRLDATNIVDADVAVV 166 ++ + T+FE T +A + Q VV+LE GLGGRLDATN+V + + Sbjct: 107 QVLALPQSQQATFFERLTATAFAVMAHWQASDPSLVVVLETGLGGRLDATNVVQPVLTAI 166 Query: 167 TSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRG 224 T++ LDH +LG I +EKAGI ++ PA++ + E + + AQ+ GA +Q G Sbjct: 167 TAMGLDHQSYLGTSMAQIAQEKAGILKAGVPAVLAPAQDEALAVLVQQAQQVGAPVQVAG 226 Query: 225 VEWNYSVTDH--DWAFSDAHGTLENLPLPLVPQP---------NAATALAALR---ASGL 270 ++ + + W +SD G L ++P+P N A A+A +R A G Sbjct: 227 QDYRWGQNNEGAGWWYSDGVGQL------MLPEPGLLGAHQYHNGAQAVAMVRQLVAQGW 280 Query: 271 EVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRV-LAV 329 V +A G+ + PGR + V ++P V D AHNP A+ + + GRV + + Sbjct: 281 SVPSSAYAAGLTAVRWPGRLERVGDAPEVWLDGAHNPAGAQVCADFFR---QYGRVDVML 337 Query: 330 IGMLHDKDIAGTLA-WLKSVVDDWYCAPLEGPRGATAEQLLE---HLG-NGKSFDSVAQA 384 ++ DKD+AG L WL+ +V G R AE L + +G ++ S Q Sbjct: 338 FALMADKDVAGMLEPWLE-LVKTVVVVEPVGGRSMAAEGLAQAWRAVGVTAETAPSTEQG 396 Query: 385 WDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 W A A +LV GS + V V +++ Sbjct: 397 WQLARKKAGHAGKILVSGSLYLVGEVKKLL 426 >UniRef50_Q8KFQ9 Folylpolyglutamate synthase n=1 Tax=Chlorobaculum tepidum RepID=Q8KFQ9_CHLTE Length = 392 Score = 154 bits (390), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 120/378 (31%), Positives = 175/378 (46%), Gaps = 25/378 (6%) Query: 54 VAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE 113 VAGTNGKGT + SI +G K G+++SPHLV +TER+R+ GQ++ + A A + Sbjct: 3 VAGTNGKGTVASCVASIFSTSGRKTGLFTSPHLVDFTERIRIDGQQIGQ-ARVAEYCTKL 61 Query: 114 SARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDH 173 + T+FE T A F +D ++E G+GGRLDATN+V ++ ++ SI +DH Sbjct: 62 QPAVETGATFFETTTAMAFAFFADEGVDAAVIETGMGGRLDATNVVQPEIVIIPSIGMDH 121 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIA---DVAQEKGALLQRRGVEWNYS 230 T+WLG I EKA I + PE A + A+ GA L + E Sbjct: 122 TEWLGGSLREIAAEKAAIIKRCSRVFTAVPEAGEAFAPIREAAEAVGAELHQVEREAECL 181 Query: 231 VTD-----HDWAFSDAHGTLENLPLPLVPQ---PNAATALAALRASGLEVSENAIRDGIA 282 V + S G L PN A+ A R+ G +S I DG+A Sbjct: 182 VEEVCPGALALRISLDGGESRQFRAALTGSFHAPNVCLAVMAARSEG--ISWEHIDDGLA 239 Query: 283 SAILPG---RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVL-AVIGMLHDKDI 338 G R + +++ P V+ DV+HNP + + L R L +IG+ DKD Sbjct: 240 RLGASGYRARLERIADKPVVMLDVSHNPEGMQKTAQSILELRNCFRFLYVIIGVAADKDA 299 Query: 339 AGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG--NGKSF----DSVAQAWDAAMADA 392 AG + + + D+ L R AE +LE L G + S A+A + Sbjct: 300 AGIVHHIAPIADEIVAVDLPVERSLQAE-VLERLCVEAGAQYVSSRHSAAEALEFLDQRV 358 Query: 393 KAEDTVLVCGSFHTVAHV 410 + ED +LV GSF+ V Sbjct: 359 EPEDMILVTGSFYLSGEV 376 >UniRef50_C1CYP7 Putative tetrahydrofolate synthase (Folylpolyglutamate synthase) n=2 Tax=Bacteria RepID=C1CYP7_DEIDV Length = 435 Score = 154 bits (390), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 129/392 (32%), Positives = 190/392 (48%), Gaps = 14/392 (3%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GL RV + RLG + A V V GTNGKG+T +L S+L A G +VG+++SPHL R+ Sbjct: 38 GLTRVHSLLTRLGEPQRAFRVVLVGGTNGKGSTAASLASMLRAQGRRVGLFTSPHLTRFA 97 Query: 91 ERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLG 150 ER V G+ LP+ S ++ I ++FE T +F +A + ++EVGLG Sbjct: 98 ERFVVGGELLPDDVVLRSLHQVRPHAEAIEASFFEIVTALGCLVFAEAGVQDAVMEVGLG 157 Query: 151 GRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE-----PEM 205 GRLDATN +D ++V+T++ALDHT+ LG E I EKAGI R +PA+ G P + Sbjct: 158 GRLDATNALDPVLSVITNVALDHTEVLGNTVELIAAEKAGILRPGRPAVTGAAPDVWPML 217 Query: 206 PSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV-PQPNAATALAA 264 + AD+ + ++R+ + W+ G PL+ ALAA Sbjct: 218 EAEGADLWSLENR-VRRQSLGWD----GEQVVVRLPAGVELTFRTPLLGAHGAQNAALAA 272 Query: 265 LRASGLEVSENAIRDGIASAILPGRFQIVSESP-RVIFDVAHNPHAAEYLTGRMKALPKN 323 A L VS AI G + PGR ++++ RV+ D AHNP AE + ++ L Sbjct: 273 AAAYRLGVSPEAISRGAQTTQWPGRMEVLTVGEGRVLLDGAHNPAGAEAVVRALRDL-GV 331 Query: 324 GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE-GPRGATAEQLLEHLGNGKSFDSVA 382 G++ V G DKD++G A L+ V PR A L + + + Sbjct: 332 GKLPLVFGAAADKDLSGVAAALEPVASQVVLTRARLSPRSADPAALAPLFPGHQVTLTES 391 Query: 383 QAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 A A LVCGS + + V ++ Sbjct: 392 PEQAIAALRALGAPLALVCGSLYLIGEVRPLL 423 >UniRef50_B3E778 FolC bifunctional protein n=3 Tax=Desulfuromonadales RepID=B3E778_GEOLS Length = 428 Score = 154 bits (388), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 114/346 (32%), Positives = 172/346 (49%), Gaps = 14/346 (4%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 P + LS L I GLER++ + R G + + V GTNGKG+T L +I+ Sbjct: 2 PASQQLSRLFGRRRFNIKPGLERITALLERHGHPERSFAAIHVVGTNGKGSTAAFLAAII 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 AGY G+++SPHLV YTER RV G + P A ++ G T+FE T A Sbjct: 62 EQAGYCTGLFTSPHLVSYTERFRVNGVDCPPEQLEALIPDLLEQAGPDD-TFFELTTALA 120 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 F + ++ + +LE G+GGR DAT V +++ IALDH WLG D +SI EK I Sbjct: 121 CHWFARNKVQLAVLEAGMGGRSDATAAVAGIATIISPIALDHCQWLGNDLQSIAAEKVAI 180 Query: 192 FRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT--DHDWAFSDAHGTLEN 247 R P I V P++ + I + + L G ++N + D F+ + G+L Sbjct: 181 ARPGSPVISAVQPPDVQAVIEEYCRTNNNRLLLAGRDFNATSNGADTGLTFTGSSGSLSG 240 Query: 248 LPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQ--IVSESPRV 299 L L A L G +S+ A++ G+A+A PGR + +++ + Sbjct: 241 LHPSLSGSYQTGNAALALAAAEQLATLGFPISQQAMQAGLATARWPGRLERLRLADGSEL 300 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 + D AHNP A+ L ++ L K R++ ++GM+ DKD+ G L L Sbjct: 301 LLDGAHNPAGAQALAAALQELGKR-RIILLLGMMEDKDLQGVLQPL 345 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B5FFN4 Bifunctional protein FolC n=7 Tax=Vibrionaceae R... 521 e-146 UniRef50_P43775 Folylpolyglutamate synthase n=258 Tax=Gammaprote... 489 e-136 UniRef50_Q604P6 Folylpolyglutamate synthase/dihydrofolate syntha... 475 e-132 UniRef50_C5CEI6 FolC bifunctional protein n=1 Tax=Kosmotoga olea... 474 e-132 UniRef50_Q12P54 FolC bifunctional protein n=10 Tax=Shewanella Re... 473 e-132 UniRef50_B6J6W5 Folylpolyglutamate synthase n=6 Tax=Coxiella bur... 471 e-131 UniRef50_B0K4K8 FolC bifunctional protein n=15 Tax=Clostridia Re... 471 e-131 UniRef50_C6P114 FolC bifunctional protein n=1 Tax=Sideroxydans l... 468 e-130 UniRef50_A0LIV6 FolC bifunctional protein n=1 Tax=Syntrophobacte... 467 e-130 UniRef50_C7N4J3 Folylpolyglutamate synthase/dihydrofolate syntha... 464 e-129 UniRef50_Q15VG0 FolC bifunctional protein n=1 Tax=Pseudoalteromo... 464 e-129 UniRef50_C6AMR7 FolC bifunctional protein n=3 Tax=Pasteurellacea... 463 e-129 UniRef50_A6VWY8 FolC bifunctional protein n=2 Tax=Marinomonas Re... 463 e-129 UniRef50_C6MBR5 FolC bifunctional protein n=1 Tax=Nitrosomonas s... 462 e-129 UniRef50_Q492H5 Folylpolyglutamate synthase n=3 Tax=Enterobacter... 462 e-129 UniRef50_B8FMP6 FolC bifunctional protein n=1 Tax=Desulfatibacil... 462 e-128 UniRef50_A5IBI5 FolC bifunctional protein n=4 Tax=Legionella pne... 461 e-128 UniRef50_Q5QWH7 Folylpolyglutamate synthase n=2 Tax=Idiomarina R... 460 e-128 UniRef50_A8PMD7 FolC bifunctional protein n=1 Tax=Rickettsiella ... 458 e-127 UniRef50_Q3JCB5 Folylpolyglutamate synthetase n=3 Tax=Gammaprote... 457 e-127 UniRef50_B0UU80 FolC bifunctional protein n=14 Tax=Pasteurellace... 457 e-127 UniRef50_Q88LD8 Folylpolyglutamate synthetase n=23 Tax=Pseudomon... 457 e-127 UniRef50_A4XL37 FolC bifunctional protein n=5 Tax=Clostridia Rep... 456 e-127 UniRef50_Q0AGX2 FolC bifunctional protein n=1 Tax=Nitrosomonas e... 456 e-127 UniRef50_C6N083 FolC bifunctional protein n=2 Tax=Legionella Rep... 455 e-126 UniRef50_C1D9J6 FolC n=26 Tax=Neisseriaceae RepID=C1D9J6_LARHH 455 e-126 UniRef50_B8DZV7 FolC bifunctional protein n=1 Tax=Dictyoglomus t... 454 e-126 UniRef50_B5YD69 Folylpolyglutamate synthase n=1 Tax=Dictyoglomus... 454 e-126 UniRef50_A2SKX9 Cytoplasmic peptidoglycan synthetase, C-terminal... 454 e-126 UniRef50_Q2BMN3 Folylpolyglutamate synthase n=1 Tax=Neptuniibact... 453 e-126 UniRef50_Q1JY09 FolC bifunctional protein n=1 Tax=Desulfuromonas... 451 e-125 UniRef50_A6GNX1 FolC bifunctional protein n=1 Tax=Limnobacter sp... 451 e-125 UniRef50_Q05865 Folylpolyglutamate synthase n=5 Tax=Bacillus sub... 451 e-125 UniRef50_A8SN77 Putative uncharacterized protein n=1 Tax=Parvimo... 449 e-125 UniRef50_B9XQF6 FolC bifunctional protein n=1 Tax=bacterium Elli... 449 e-124 UniRef50_A1SW71 FolC bifunctional protein n=2 Tax=Psychromonas R... 449 e-124 UniRef50_Q3IF42 Bifunctional: folylpolyglutamate synthase; dihyd... 449 e-124 UniRef50_D2RP25 FolC bifunctional protein n=2 Tax=Acidaminococcu... 448 e-124 UniRef50_D0WG21 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 447 e-124 UniRef50_A1UZ44 FolC bifunctional protein n=107 Tax=cellular org... 447 e-124 UniRef50_B8FVG3 FolC bifunctional protein n=2 Tax=Desulfitobacte... 446 e-124 UniRef50_B9MJT0 FolC bifunctional protein n=2 Tax=Clostridiales ... 446 e-124 UniRef50_B5JSE1 FolC bifunctional protein n=1 Tax=gamma proteoba... 445 e-123 UniRef50_Q6FEE4 Bifunctional protein n=18 Tax=Acinetobacter RepI... 445 e-123 UniRef50_C0QB10 FolC n=1 Tax=Desulfobacterium autotrophicum HRM2... 445 e-123 UniRef50_A7C245 Folylpolyglutamate synthase/dihydrofolate syntha... 444 e-123 UniRef50_C0GEY6 FolC bifunctional protein n=1 Tax=Dethiobacter a... 443 e-123 UniRef50_A8ZTL3 FolC bifunctional protein n=1 Tax=Desulfococcus ... 443 e-123 UniRef50_C7H9L3 Tetrahydrofolate synthase n=2 Tax=Faecalibacteri... 442 e-123 UniRef50_B0VF02 FolC bifunctional protein n=1 Tax=Candidatus Clo... 442 e-122 UniRef50_Q0A999 FolC bifunctional protein n=1 Tax=Alkalilimnicol... 440 e-122 UniRef50_Q71ZB7 FolC bifunctional protein n=12 Tax=Listeria RepI... 440 e-122 UniRef50_Q3AF86 Folylpolyglutamate synthase n=1 Tax=Carboxydothe... 440 e-122 UniRef50_B5EAK4 FolC bifunctional protein n=6 Tax=Geobacter RepI... 439 e-122 UniRef50_A6FEP3 Dihydrofolate synthase / folylpolyglutamate synt... 439 e-122 UniRef50_B8DHJ7 Folylpolyglutamate synthase (Folylpoly-gamma-glu... 439 e-122 UniRef50_B8I1X5 FolC bifunctional protein n=2 Tax=Clostridium Re... 439 e-122 UniRef50_C0ZAJ3 Folylpolyglutamate synthase n=1 Tax=Brevibacillu... 439 e-121 UniRef50_A6TN35 FolC bifunctional protein n=2 Tax=Alkaliphilus R... 438 e-121 UniRef50_C7MLS9 Folylpolyglutamate synthase/dihydrofolate syntha... 438 e-121 UniRef50_A5I6P2 FolC bifunctional protein n=14 Tax=Clostridia Re... 438 e-121 UniRef50_A0AJ00 FolC protein n=2 Tax=Listeria RepID=A0AJ00_LISW6 437 e-121 UniRef50_C8QY00 FolC bifunctional protein n=1 Tax=Desulfurivibri... 436 e-121 UniRef50_Q2LQC5 Folylpolyglutamate synthase / dihydrofolate synt... 436 e-121 UniRef50_B2J1B6 FolC bifunctional protein n=25 Tax=Bacteria RepI... 436 e-120 UniRef50_C6WVE3 FolC bifunctional protein n=1 Tax=Methylotenera ... 435 e-120 UniRef50_A8UBK8 Folyl-polyglutamate synthetase n=1 Tax=Carnobact... 434 e-120 UniRef50_A6C8Q2 Folyl-polyglutamate synthetase n=1 Tax=Planctomy... 434 e-120 UniRef50_C9LMI1 Tetrahydrofolate synthase n=1 Tax=Dialister invi... 434 e-120 UniRef50_B7RU63 FolC bifunctional protein n=1 Tax=marine gamma p... 434 e-120 UniRef50_Q5CB75 Folylpolyglutamate synthase/dihydrofolate syntha... 433 e-120 UniRef50_B8KYD9 Folylpolyglutamate synthase n=1 Tax=gamma proteo... 433 e-120 UniRef50_Q9K8G9 Folyl-polyglutamate synthetase n=1 Tax=Bacillus ... 432 e-119 UniRef50_C9RB31 FolC bifunctional protein n=1 Tax=Ammonifex dege... 432 e-119 UniRef50_Q1N6P7 Folylpolyglutamate synthetase n=1 Tax=Bermanella... 432 e-119 UniRef50_A8FFU4 Tetrahydrofolate synthase n=88 Tax=Bacillaceae R... 431 e-119 UniRef50_Q8K9X3 Dihydrofolate synthase n=1 Tax=Buchnera aphidico... 431 e-119 UniRef50_Q8D2P3 FolC protein n=1 Tax=Wigglesworthia glossinidia ... 431 e-119 UniRef50_B2V618 FolC bifunctional protein n=3 Tax=Sulfurihydroge... 431 e-119 UniRef50_A7VV81 Putative uncharacterized protein n=1 Tax=Clostri... 431 e-119 UniRef50_Q1PZI3 Similar to multifunctional folylpolyglutamate sy... 430 e-119 UniRef50_UPI0000E0E8A2 FolC bifunctional protein n=1 Tax=Rhodoba... 430 e-119 UniRef50_B5YJI6 Folylpolyglutamate synthase n=1 Tax=Thermodesulf... 430 e-119 UniRef50_C9KNY5 Tetrahydrofolate synthase n=2 Tax=Veillonellacea... 429 e-118 UniRef50_Q02Z16 Folylpolyglutamate synthase n=20 Tax=Bacteria Re... 429 e-118 UniRef50_C5SCQ4 FolC bifunctional protein n=1 Tax=Allochromatium... 429 e-118 UniRef50_Q3A6L0 Folylpolyglutamate synthetase; dihydrofolate syn... 428 e-118 UniRef50_C2E893 Folylpolyglutamate synthase / dihydrofolate synt... 427 e-118 UniRef50_Q2JLQ4 Folylpolyglutamate synthase n=2 Tax=Synechococcu... 427 e-118 UniRef50_Q1D8V1 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 427 e-118 UniRef50_Q89AT2 Dihydrofolate synthase n=4 Tax=Buchnera aphidico... 427 e-118 UniRef50_B0S2B5 Folylpolyglutamate synthase n=2 Tax=Finegoldia m... 426 e-118 UniRef50_Q01UR3 FolC bifunctional protein n=1 Tax=Candidatus Sol... 426 e-118 UniRef50_Q31HH1 FolC bifunctional folylpolyglutamate synthase/di... 426 e-118 UniRef50_UPI0000E88026 folylpolyglutamate synthetase n=1 Tax=Met... 426 e-117 UniRef50_D1BNH4 FolC bifunctional protein n=3 Tax=Veillonella Re... 426 e-117 UniRef50_Q47XK6 FolC bifunctional protein n=1 Tax=Colwellia psyc... 425 e-117 UniRef50_A8MIR1 FolC bifunctional protein n=1 Tax=Alkaliphilus o... 425 e-117 UniRef50_Q38XD0 Putative polylpolyglutamate synthase n=1 Tax=Lac... 425 e-117 UniRef50_A5N275 FolC n=22 Tax=Clostridium RepID=A5N275_CLOK5 424 e-117 UniRef50_B4RUR1 Bifunctional folylpolyglutamate synthase/dihydro... 424 e-117 UniRef50_A0YB05 FolC bifunctional protein n=1 Tax=marine gamma p... 424 e-117 UniRef50_C1I5V8 FolC bifunctional protein n=1 Tax=Clostridium sp... 424 e-117 UniRef50_B9L391 Folylpolyglutamate synthase (Folylpoly-gamma-glu... 424 e-117 UniRef50_Q6AJ73 Related to folylpolyglutamate synthase n=3 Tax=D... 424 e-117 UniRef50_Q12D50 FolC bifunctional protein n=4 Tax=Proteobacteria... 423 e-117 UniRef50_A1U0X0 FolC bifunctional protein n=3 Tax=Marinobacter R... 423 e-117 UniRef50_Q28WD6 FolC bifunctional protein n=2 Tax=Rhodobacterale... 422 e-116 UniRef50_C0CJ78 Putative uncharacterized protein n=2 Tax=Clostri... 422 e-116 UniRef50_Q2SJC8 Folylpolyglutamate synthase n=1 Tax=Hahella chej... 422 e-116 UniRef50_C9L620 Tetrahydrofolate synthase n=1 Tax=Blautia hansen... 422 e-116 UniRef50_Q5WEQ5 Folylpolyglutamate synthase n=1 Tax=Bacillus cla... 421 e-116 UniRef50_C5CFS4 FolC bifunctional protein n=1 Tax=Kosmotoga olea... 421 e-116 UniRef50_Q1WT76 Folylpolyglutamate synthase / Dihydrofolate synt... 420 e-116 UniRef50_C6J218 Bifunctional protein folC n=1 Tax=Paenibacillus ... 420 e-116 UniRef50_C0QUQ6 Folylpolyglutamate synthetase n=2 Tax=Aquificale... 419 e-116 UniRef50_A9KNK7 FolC bifunctional protein n=1 Tax=Clostridium ph... 419 e-115 UniRef50_Q1QDK0 FolC bifunctional protein n=4 Tax=Moraxellaceae ... 418 e-115 UniRef50_A5ZW55 Putative uncharacterized protein n=1 Tax=Ruminoc... 418 e-115 UniRef50_C6D869 FolC bifunctional protein n=3 Tax=Bacillales Rep... 417 e-115 UniRef50_A9QPJ9 Folylpolyglutamate synthase n=1 Tax=Methylacidip... 417 e-115 UniRef50_B2A1F3 FolC bifunctional protein n=1 Tax=Natranaerobius... 416 e-115 UniRef50_B3PFP2 Folylpolyglutamate synthetase n=1 Tax=Cellvibrio... 416 e-114 UniRef50_B8CY17 Folylpolyglutamate synthase n=1 Tax=Halothermoth... 416 e-114 UniRef50_Q1GD59 FolC bifunctional protein n=6 Tax=Alphaproteobac... 415 e-114 UniRef50_A1HP48 FolC bifunctional protein n=1 Tax=Thermosinus ca... 415 e-114 UniRef50_C8ZWR3 FolC family protein n=26 Tax=Enterococcus RepID=... 414 e-114 UniRef50_UPI0001745D4D FolC bifunctional protein n=1 Tax=Verruco... 414 e-114 UniRef50_B0MBL9 Putative uncharacterized protein n=2 Tax=Clostri... 414 e-114 UniRef50_C6VI65 Folylpolyglutamate synthase n=8 Tax=Bacilli RepI... 414 e-114 UniRef50_D2QCN6 FolC bifunctional protein n=1 Tax=Spirosoma ling... 414 e-114 UniRef50_B4CZE0 FolC bifunctional protein n=1 Tax=Chthoniobacter... 414 e-114 UniRef50_D1PA28 Tetrahydrofolate synthase n=1 Tax=Prevotella cop... 414 e-114 UniRef50_Q03EP1 Folylpolyglutamate synthase n=2 Tax=Pediococcus ... 414 e-114 UniRef50_D1PK55 Tetrahydrofolate synthase n=1 Tax=Subdoligranulu... 414 e-114 UniRef50_C2ETR7 Tetrahydrofolate synthase n=3 Tax=Lactobacillus ... 414 e-114 UniRef50_D0MEF9 FolC bifunctional protein n=1 Tax=Rhodothermus m... 413 e-114 UniRef50_UPI0001C42143 folyl-polyglutamate synthetase n=1 Tax=Ba... 413 e-114 UniRef50_A4A847 Folylpolyglutamate synthase/dihydrofolate syntha... 413 e-114 UniRef50_A8RF48 Putative uncharacterized protein n=1 Tax=Eubacte... 413 e-114 UniRef50_C0CPE6 Putative uncharacterized protein n=2 Tax=Clostri... 412 e-113 UniRef50_C6Y3V5 FolC bifunctional protein n=4 Tax=Sphingobacteri... 412 e-113 UniRef50_Q0AWF7 Putative uncharacterized protein n=1 Tax=Syntrop... 412 e-113 UniRef50_A8F8Q4 FolC bifunctional protein n=1 Tax=Thermotoga let... 410 e-113 UniRef50_C7RCA3 FolC bifunctional protein n=1 Tax=Kangiella kore... 410 e-113 UniRef50_D1AJ52 FolC bifunctional protein n=1 Tax=Sebaldella ter... 410 e-113 UniRef50_B3QVA8 FolC bifunctional protein n=1 Tax=Chloroherpeton... 410 e-113 UniRef50_D2R4J4 FolC bifunctional protein n=1 Tax=Pirellula stal... 409 e-112 UniRef50_C2BDR7 Possible tetrahydrofolate synthase n=2 Tax=Anaer... 409 e-112 UniRef50_B1CAR2 Putative uncharacterized protein n=1 Tax=Anaerof... 409 e-112 UniRef50_Q67SJ1 Folylpolyglutamate synthase n=1 Tax=Symbiobacter... 409 e-112 UniRef50_C0EVS7 Putative uncharacterized protein n=1 Tax=Eubacte... 408 e-112 UniRef50_Q7NLP7 Folylpolyglutamate synthase n=1 Tax=Gloeobacter ... 408 e-112 UniRef50_B3ELQ9 FolC bifunctional protein n=2 Tax=Chlorobiaceae ... 407 e-112 UniRef50_C6W460 FolC bifunctional protein n=7 Tax=Bacteroidetes ... 407 e-112 UniRef50_A5FMS8 FolC bifunctional protein n=21 Tax=Bacteroidetes... 407 e-112 UniRef50_Q1QY39 FolC bifunctional protein n=1 Tax=Chromohalobact... 407 e-112 UniRef50_B9ZQU2 FolC bifunctional protein n=1 Tax=Thioalkalivibr... 407 e-112 UniRef50_D0KZW9 FolC bifunctional protein n=1 Tax=Halothiobacill... 405 e-111 UniRef50_UPI0001BC3950 FolC bifunctional protein n=1 Tax=Butyriv... 405 e-111 UniRef50_B1HVC8 Folylpolyglutamate synthase n=2 Tax=Bacillaceae ... 404 e-111 UniRef50_C2KWA8 Possible tetrahydrofolate synthase n=1 Tax=Oriba... 404 e-111 UniRef50_C6LLD0 Tetrahydrofolate synthase n=3 Tax=Clostridiales ... 404 e-111 UniRef50_A6LA17 Folylpolyglutamate synthase n=8 Tax=Bacteroidale... 404 e-111 UniRef50_B4VMJ0 FolC bifunctional protein n=2 Tax=Cyanobacteria ... 404 e-111 UniRef50_B6JCP5 FolC bifunctional protein n=17 Tax=Alphaproteoba... 403 e-111 UniRef50_B2GB02 Folylpolyglutamate synthase n=11 Tax=Lactobacill... 403 e-111 UniRef50_B0MYL2 Putative uncharacterized protein n=1 Tax=Alistip... 403 e-111 UniRef50_A5TUM3 Tetrahydrofolate synthase n=15 Tax=Fusobacterium... 402 e-110 UniRef50_B1FP43 FolC bifunctional protein n=1 Tax=Burkholderia a... 402 e-110 UniRef50_D1CGA1 FolC bifunctional protein n=1 Tax=Thermobaculum ... 401 e-110 UniRef50_A3CKF3 Dihydrofolate synthetase, putative n=32 Tax=Stre... 401 e-110 UniRef50_A9BIJ6 FolC bifunctional protein n=1 Tax=Petrotoga mobi... 400 e-110 UniRef50_UPI0001C16345 Folylpolyglutamate synthetase n=2 Tax=Nos... 400 e-110 UniRef50_UPI00016C3FCF FolC bifunctional protein n=1 Tax=Gemmata... 400 e-110 UniRef50_C0EHC4 Putative uncharacterized protein n=1 Tax=Clostri... 400 e-110 UniRef50_C6LLF0 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 400 e-110 UniRef50_Q11UV3 Tetrahydrofolylpolyglutamate synthase (Folylpoly... 400 e-110 UniRef50_A4BHC7 FolC bifunctional folylpolyglutamate synthase/di... 400 e-110 UniRef50_C5BL57 FolC bifunctional protein n=1 Tax=Teredinibacter... 399 e-109 UniRef50_Q3B220 Folylpolyglutamate synthetase n=8 Tax=Chlorobiac... 399 e-109 UniRef50_B8GQE7 FolC bifunctional protein n=1 Tax=Thioalkalivibr... 398 e-109 UniRef50_A8YUM7 Folylpolyglutamate synthase n=28 Tax=Lactobacill... 398 e-109 UniRef50_C7JGW9 Bifunctional protein FolC n=8 Tax=Acetobacter pa... 398 e-109 UniRef50_C3J886 Folylpolyglutamate synthase n=15 Tax=Bacteria Re... 397 e-109 UniRef50_A6DMK1 Folylpolyglutamate synthase n=1 Tax=Lentisphaera... 397 e-109 UniRef50_UPI0001C36E14 FolC bifunctional protein n=1 Tax=Ruminoc... 396 e-109 UniRef50_B1YJU6 FolC bifunctional protein n=2 Tax=Exiguobacteriu... 395 e-108 UniRef50_P15925 Folylpolyglutamate synthase n=9 Tax=Lactobacillu... 395 e-108 UniRef50_Q31PP5 FolC bifunctional protein n=2 Tax=Synechococcus ... 394 e-108 UniRef50_C9M7C2 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 394 e-108 UniRef50_D2RA71 Bifunctional protein FolC n=3 Tax=Bifidobacteria... 394 e-108 UniRef50_Q21IZ3 FolC bifunctional protein n=1 Tax=Saccharophagus... 393 e-108 UniRef50_A5KJF0 Putative uncharacterized protein n=4 Tax=Clostri... 393 e-108 UniRef50_Q13EP9 FolC bifunctional protein n=37 Tax=Alphaproteoba... 393 e-108 UniRef50_A5Z386 Putative uncharacterized protein n=1 Tax=Eubacte... 393 e-108 UniRef50_A7NFK2 FolC bifunctional protein n=2 Tax=Roseiflexus Re... 393 e-108 UniRef50_D1N952 FolC bifunctional protein n=1 Tax=Victivallis va... 392 e-107 UniRef50_A1AXP8 FolC bifunctional protein n=5 Tax=Bacteria RepID... 392 e-107 UniRef50_B5ZCR5 FolC bifunctional protein n=2 Tax=Gluconacetobac... 392 e-107 UniRef50_D0WR93 Tetrahydrofolate synthase n=2 Tax=Actinomycetale... 392 e-107 UniRef50_A8RZ26 Putative uncharacterized protein n=1 Tax=Clostri... 391 e-107 UniRef50_D1AAV2 FolC bifunctional protein n=1 Tax=Thermomonospor... 391 e-107 UniRef50_B6BU94 Folylpolyglutamate synthase/dihydrofolate syntha... 391 e-107 UniRef50_A8RV28 Putative uncharacterized protein n=1 Tax=Clostri... 391 e-107 UniRef50_Q49Y95 Folylpolyglutamate synthase n=66 Tax=Staphylococ... 390 e-107 UniRef50_A0LA36 FolC bifunctional protein n=2 Tax=cellular organ... 390 e-107 UniRef50_A8SU33 Putative uncharacterized protein n=2 Tax=Clostri... 389 e-107 UniRef50_A1WY03 FolC bifunctional protein n=1 Tax=Halorhodospira... 389 e-107 UniRef50_B1VGM7 Dihydrofolate synthase / folylpolyglutamate synt... 389 e-106 UniRef50_C4V4R4 Possible tetrahydrofolate synthase n=2 Tax=Selen... 389 e-106 UniRef50_B3DQR8 Folylpolyglutamate synthase n=18 Tax=Bifidobacte... 389 e-106 UniRef50_C4LJV2 Dihydrofolate synthase / folylpolyglutamate synt... 388 e-106 UniRef50_B3E778 FolC bifunctional protein n=3 Tax=Desulfuromonad... 387 e-106 UniRef50_Q6KZL1 Folylpolyglutamate synthase/dihydrofolate syntha... 387 e-106 UniRef50_Q2NZP7 Folylpolyglutamate synthase n=19 Tax=Xanthomonad... 387 e-106 UniRef50_B1ZVD5 FolC bifunctional protein n=4 Tax=Verrucomicrobi... 387 e-106 UniRef50_Q0BQJ2 Folylpolyglutamate synthase n=2 Tax=Acetobactera... 387 e-106 UniRef50_B0TC04 Folylpolyglutamate synthase n=5 Tax=Clostridia R... 387 e-106 UniRef50_C4Z2M8 Folylpolyglutamate synthase n=1 Tax=Eubacterium ... 387 e-106 UniRef50_B4RCL3 Bifunctional dihydrofolate synthase/folylpolyglu... 386 e-106 UniRef50_B1H0E2 Folylpolyglutamate synthetase n=1 Tax=uncultured... 386 e-106 UniRef50_Q97AP2 Folylpolyglutamate synthase n=2 Tax=Thermoplasma... 386 e-106 UniRef50_B5Y836 Folylpolyglutamate synthase/dihydrofolate syntha... 385 e-105 UniRef50_A1ZCQ8 Folylpolyglutamate synthase n=1 Tax=Microscilla ... 385 e-105 UniRef50_A0Z5L0 Folylpolyglutamate synthase/dihydrofolate syntha... 385 e-105 UniRef50_C1CYP7 Putative tetrahydrofolate synthase (Folylpolyglu... 385 e-105 UniRef50_Q6MAP9 Putative folylpolyglutamate synthase n=1 Tax=Can... 385 e-105 UniRef50_B7ARH5 Putative uncharacterized protein n=1 Tax=Bactero... 385 e-105 UniRef50_Q3ZAH8 Folylpolyglutamate synthetase n=5 Tax=Dehalococc... 385 e-105 UniRef50_A5EVX7 Folylpolyglutamate synthase n=2 Tax=Cardiobacter... 385 e-105 UniRef50_C8WXM1 FolC bifunctional protein n=2 Tax=Alicyclobacill... 384 e-105 UniRef50_B9KIR3 Folylpolyglutamate synthase (FolC) n=5 Tax=Ricke... 384 e-105 UniRef50_B0T696 FolC bifunctional protein n=2 Tax=Alphaproteobac... 384 e-105 UniRef50_A6BCX0 Putative uncharacterized protein n=9 Tax=Clostri... 384 e-105 UniRef50_Q1IVH6 FolC bifunctional protein n=2 Tax=Acidobacteria ... 383 e-105 UniRef50_B2IS30 Dihydrofolate synthetase, putative n=37 Tax=Bact... 383 e-105 UniRef50_Q1JHI7 Folylpolyglutamate synthase / Dihydrofolate synt... 383 e-105 UniRef50_B5IFG1 FolC bifunctional protein n=2 Tax=Aciduliprofund... 383 e-105 UniRef50_C7GYL0 Tetrahydrofolate synthase n=1 Tax=Eubacterium sa... 383 e-105 UniRef50_C0FMZ7 Putative uncharacterized protein n=1 Tax=Rosebur... 383 e-105 UniRef50_D2LRU4 FolC bifunctional protein n=1 Tax=Bacillus cellu... 383 e-105 UniRef50_C8P2J5 Folylpolyglutamate synthase (Tetrahydrofolate sy... 382 e-104 UniRef50_C2BRT3 Possible tetrahydrofolate synthase n=3 Tax=Mobil... 381 e-104 UniRef50_UPI0001C34EE0 FolC bifunctional protein n=1 Tax=Clostri... 381 e-104 UniRef50_C7RHW8 FolC bifunctional protein n=3 Tax=Anaerococcus R... 381 e-104 UniRef50_A3ZWP1 Folyl-polyglutamate synthetase n=1 Tax=Blastopir... 381 e-104 UniRef50_D1VUP4 Tetrahydrofolate synthase n=1 Tax=Peptoniphilus ... 380 e-104 UniRef50_B6YQL7 Folylpolyglutamate synthase n=7 Tax=Bacteroidale... 380 e-104 UniRef50_A4BRV9 Folylpolyglutamate synthase/dihydrofolate syntha... 379 e-103 Sequences not found previously or not previously below threshold: >UniRef50_B5FFN4 Bifunctional protein FolC n=7 Tax=Vibrionaceae RepID=B5FFN4_VIBFM Length = 426 Score = 521 bits (1342), Expect = e-146, Method: Composition-based stats. Identities = 220/421 (52%), Positives = 287/421 (68%), Gaps = 8/421 (1%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M +P+A S L+ WL YLE++H+ IDLGL+RV VA R + KPAP V TVAGTNGK Sbjct: 1 MTTFDSPKATSDLSMWLRYLESIHTSAIDLGLDRVQRVAQRAKLTKPAPTVITVAGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 G+TC +ESIL+ AGY+VGVYSSPHL+RY ER+R+ G +L +S + SFA IE+ R DIS Sbjct: 61 GSTCALMESILINAGYRVGVYSSPHLIRYNERIRINGNDLSDSLISQSFAAIEAWRKDIS 120 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 L+ FE+GTLSALW FK Q+DVV+LEVGLGGRLDATN+VD DV+++TS+A+DH DWLG D Sbjct: 121 LSLFEFGTLSALWAFKAHQVDVVLLEVGLGGRLDATNVVDHDVSIITSLAVDHVDWLGDD 180 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV--TDHDWAF 238 E IG EKAGIFRSEK AI G+P PS++A A + A L + G +++Y+V W++ Sbjct: 181 IEVIGFEKAGIFRSEKAAICGQPNPPSSVAAHADDINADLYQVGYQFDYNVHADTQTWSW 240 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES-- 296 L+NLPLP +P NAATA+ AL SGLE+S+ I +G+ SA LPGR Q ++ Sbjct: 241 KSGAFDLDNLPLPNLPLANAATAIMALGVSGLELSDINIVEGLKSARLPGRMQRLTRGNS 300 Query: 297 ---PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 P +I DVAHNPH+A YL +++ N ++ AV+GMLHDKDI TL V+D WY Sbjct: 301 EFEPTIILDVAHNPHSAHYLVQQVRQRFPNKKIHAVVGMLHDKDIKSTLGEFTGVIDVWY 360 Query: 354 CAPLEGPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A L GPR A A +L L + S A+ A+ A+++D +LV GSFHTV V + Sbjct: 361 PASLSGPRAANASELTAVLSKEITEYSSPVDAFKVALQQAESDDLILVFGSFHTVGEVWD 420 Query: 413 V 413 Sbjct: 421 Y 421 >UniRef50_P43775 Folylpolyglutamate synthase n=258 Tax=Gammaproteobacteria RepID=FOLC_HAEIN Length = 437 Score = 489 bits (1259), Expect = e-136, Method: Composition-based stats. Identities = 214/432 (49%), Positives = 279/432 (64%), Gaps = 25/432 (5%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 +A SPLA WLSYLE H K IDLGL+R+ VA +L +L P P+V TV GTNGKGTTCR L Sbjct: 7 KATSPLAEWLSYLEKSHFKPIDLGLDRIKSVAEKLDLLHPVPYVITVGGTNGKGTTCRLL 66 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 E+IL+ G +VGVYSSPHL+RY ERVR+Q Q+LP+ AHTASFA I+ + + SLTYFE+ Sbjct: 67 ETILLNHGLRVGVYSSPHLLRYNERVRIQNQDLPDEAHTASFAFIDENKTE-SLTYFEFS 125 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 TLSAL LFKQA+LDVVILEVGLGGRLDATNIVD+ +AV+TSI +DHTD+LG RE+I E Sbjct: 126 TLSALHLFKQAKLDVVILEVGLGGRLDATNIVDSHLAVITSIDIDHTDFLGDTREAIAFE 185 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 KAGIFR P ++GEP +P T+ D A++ + RR V+W + +W + + LEN Sbjct: 186 KAGIFRENCPVVIGEPNVPQTMLDQAEKLHCQVARRDVDWLFEQNAENWQWQNKKVRLEN 245 Query: 248 LPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES----------- 296 LP +P NAAT LAA++ ++SE +R + L GRFQ + Sbjct: 246 LPFCQIPLANAATVLAAVQYLPFDISEQTLRKSLQEVELVGRFQAIKTDKREKLADYLGV 305 Query: 297 -----PRVIFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVV 349 P +I DV HNPHAA+YL+ ++ AL + G+++AV GML DKD G L ++ Sbjct: 306 PVETLPTIIVDVGHNPHAAKYLSEKLTALKRSIEGKMIAVCGMLKDKDANGVFEHLTPII 365 Query: 350 DDWYCAPLEGPRGATAEQLLEHLG------NGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 D+W+C L G RG + ++L+E L S +SV A+ A D VLV GS Sbjct: 366 DEWHCVTLGGYRGQSGDELVEKLKSHFPNIQATSDNSVMDGVCTALKSAVKNDVVLVFGS 425 Query: 404 FHTVAHVMEVID 415 FHTVA V++ Sbjct: 426 FHTVAEFWAVVE 437 >UniRef50_Q604P6 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Methylococcus capsulatus RepID=Q604P6_METCA Length = 431 Score = 475 bits (1224), Expect = e-132, Method: Composition-based stats. Identities = 185/417 (44%), Positives = 252/417 (60%), Gaps = 12/417 (2%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 S L WLS+ E LH + IDLGLERV V L + PF TV GTNGKG+ L++I Sbjct: 4 STLGEWLSWQETLHPQAIDLGLERVRRVYRALNPAQDRPFTITVGGTNGKGSCVAALDTI 63 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L AGY+VG Y+SPH++RY ER+ + G + ++A ASF IE+ RGD +L++FE+GTL+ Sbjct: 64 LRRAGYRVGAYTSPHILRYNERICIDGTPVDDAAICASFERIEAVRGDTTLSFFEFGTLA 123 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ +F++A+LDV ILEVGLGGRLDA NIVDAD A+V SI +DH +WLG RE+IG EKAG Sbjct: 124 AMDIFRRAELDVQILEVGLGGRLDAVNIVDADAALVASIGIDHEEWLGLTREAIGLEKAG 183 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 IFR +P I+G+P+ P+T+ A+ GA L +G ++++ + W + T LP Sbjct: 184 IFRPARPCILGDPDAPATVLRHAEAIGADLLMQGRDFSFRRENDGWTWYGRGETHAALPE 243 Query: 251 PLV----PQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 P + N A L + A L V E A+R G+AS LPGRFQI P V+ DVA Sbjct: 244 PCLRGDHQYFNMAAVLQVIEAIRPRLPVPEAAVRAGLASVHLPGRFQIQEGEPTVLLDVA 303 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNPHA L ++ + V AV M+ DKDI G + ++ +VDDWY APL+ PR AT Sbjct: 304 HNPHAVRVLAEFLRQFKRGRPVHAVFAMMRDKDIRGVVECIRDLVDDWYLAPLQLPRAAT 363 Query: 365 AEQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 E LL + F A+ + +A+ + +LV GSF VA + I+ Sbjct: 364 PEILLPVFSALGISQVQQGFADAAEVFARVRRNAENDSIILVFGSFFLVAEYLARIE 420 >UniRef50_C5CEI6 FolC bifunctional protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CEI6_KOSOT Length = 428 Score = 474 bits (1221), Expect = e-132, Method: Composition-based stats. Identities = 138/426 (32%), Positives = 213/426 (50%), Gaps = 23/426 (5%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L YL +L I G+ R+ ++ LG + + V VAGTNGKG+T + SIL Sbjct: 2 DYKEALDYLYSLRRFGIKPGVRRIKMLLELLGNPQDSLNVVHVAGTNGKGSTVAFISSIL 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFE 125 AGY+VG Y SPHL+ +TER+ + G ++ E +I ++ S T+FE Sbjct: 62 KEAGYRVGTYISPHLIDFTERMTINGLQIKEEVVVEILNKIRPHITEVANSKFGSPTFFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T A FKQ ++D +LEVGLGG DATN+V V+V+T+ DH D LG D SI Sbjct: 122 VVTAMAFVYFKQQKVDFAVLEVGLGGENDATNVVKPLVSVITNSDYDHMDILGNDITSIA 181 Query: 186 REKAGIFRSEKPAIV-GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS----- 239 +E AGI + + E E I + +EK A + + G + Y + D + Sbjct: 182 KEDAGIIKENGFVVTAAEGEALDVIKKIGEEKRARIYQIGRDIKYEFVNSDLKWQRFNVK 241 Query: 240 DAHGTLENLPLPLVPQP------NAATALAALRASGLEVSENAIRDGIASAILPGRFQIV 293 +NL +PL+ + A A+ LR +E+S+ +IR G+ + PGRF+IV Sbjct: 242 GIFSESDNLKIPLLGKYQLINASCAVGAIEILRFYDIEISDESIRKGLENTFWPGRFEIV 301 Query: 294 SESPRVIFDVAHNPHAAEYLTGRM-KALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 ++P V+ D AHN AA+ L + + L K +++ VIG++ DK++ + L + Sbjct: 302 QDAPMVVLDGAHNHLAAKRLKEALMEVLEKKDKLILVIGIMKDKEVEKIVKELAPLAYKV 361 Query: 353 YCAPLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 + PR T+ L E + N + V A + A+++AK D V V GS +TV Sbjct: 362 VATSPKTPRATTSHDLREIVVKFNKNISVVEDVETALELALSEAKENDIVCVTGSLYTVG 421 Query: 409 HVMEVI 414 + + Sbjct: 422 EARKFL 427 >UniRef50_Q12P54 FolC bifunctional protein n=10 Tax=Shewanella RepID=Q12P54_SHEDO Length = 448 Score = 473 bits (1218), Expect = e-132, Method: Composition-based stats. Identities = 205/425 (48%), Positives = 286/425 (67%), Gaps = 16/425 (3%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNGKGTTC 64 P+ + L WL YL ++H ID+GL RVS VA +L +L AP V TVAGTNGKGT+C Sbjct: 22 RPKQGATLQDWLDYLLSIHPAEIDMGLSRVSQVAKQLQLLDLAPAQVITVAGTNGKGTSC 81 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 LES+L AG +VGVYSSPHL+ Y ERVR+QG + + A A+F+ IE+ARG ISLT+F Sbjct: 82 AMLESVLSFAGKRVGVYSSPHLIHYNERVRIQGVDASDEALIAAFSAIEAARGAISLTFF 141 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 EY TL+ LWLFK A+LDV+ILEVGLGGRLDATN++DAD+ ++TSIALDH ++LG RE++ Sbjct: 142 EYATLAGLWLFKAAKLDVIILEVGLGGRLDATNMIDADICLLTSIALDHQEYLGDTREAV 201 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 GREKAG+FR+ + A++GEP +P T+ D A++ G + R G E++Y + W+F+ + Sbjct: 202 GREKAGVFRANRLAVIGEPALPITVTDYAEQIGTPVCRVGHEFSYEAQGNTWSFNSPNRQ 261 Query: 245 LENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 + L LP++P NAA+ +A L E+S+ + GI A L GRF+ +S SP VI DVA Sbjct: 262 IAALALPVLPLANAASVVALLTQRWPEISDEQLSLGIGQARLAGRFETLSTSPLVIVDVA 321 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNPHAA YL ++ ++ R+LA+ ML DKD+AG L+ L VVD WY A L+ RGA+ Sbjct: 322 HNPHAAAYLAKQL-SVFNGKRILALCAMLKDKDMAGVLSELTDVVDAWYFASLQNERGAS 380 Query: 365 AEQLLEHLGNGKS--------------FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 A QL L ++ F+S++Q W A +A+ +D ++V GSF+TVA + Sbjct: 381 ASQLSAALEQTQAQALEVNLALTQVLEFESLSQGWKALTLEAQEDDIIIVFGSFYTVAGI 440 Query: 411 MEVID 415 +++ Sbjct: 441 KALLE 445 >UniRef50_B6J6W5 Folylpolyglutamate synthase n=6 Tax=Coxiella burnetii RepID=B6J6W5_COXB1 Length = 416 Score = 471 bits (1214), Expect = e-131, Method: Composition-based stats. Identities = 178/416 (42%), Positives = 258/416 (62%), Gaps = 7/416 (1%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + +WL+Y+ +LHS+ IDLGL R++ +A +L + A V TVAGTNGKG+ ++LESI + Sbjct: 1 MKNWLAYINSLHSREIDLGLSRITSLAEKLSLNNFACPVVTVAGTNGKGSVVKSLESIYL 60 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AAGYKV Y+SPHL+++ ER+R+ G+ + +F IE R L++FE+ TL+ Sbjct: 61 AAGYKVAAYTSPHLLQFNERLRLNGEPATDELFIEAFKFIEDNRNHQPLSFFEFTTLAIF 120 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 ++ K+ LD+++LEVGLGGRLDA NIV+ DVAV+T+I +DHTDWLG DRESIGREKAGI Sbjct: 121 YICKKQNLDILLLEVGLGGRLDAVNIVEPDVAVITTIDIDHTDWLGEDRESIGREKAGII 180 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 R KP I G+P +P+++ + A + ++ T +W + + LPLP Sbjct: 181 RRHKPVIGGDPNLPNSVYEQVHLLEAPFYQLEKDFFAVSTKENWQWQGPTQDYQGLPLPS 240 Query: 253 VPQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 + N AT+L + S L VS++++ GI +A+LPGRF+ + ++FDVAHNP A Sbjct: 241 LKIENIATSLMVIHCLQSQLPVSQHSLIAGIKNAVLPGRFEWIQTPAPIVFDVAHNPQAT 300 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 YL+ +++ GR L V+GML DKDI G L + +D WY L RGAT+ L Sbjct: 301 AYLSEQLRKTDHAGRTLGVVGMLRDKDIPGALKPMLPCIDQWYAGTLSESRGATSANLQN 360 Query: 371 HLG-----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSGG 421 L N FDSVA A+ A+ D + +D ++V GSF+TVA EV+ +G Sbjct: 361 VLSELQVENCYDFDSVADAFKKAVEDCRPQDRIVVFGSFYTVAMAKEVLLGGENGN 416 >UniRef50_B0K4K8 FolC bifunctional protein n=15 Tax=Clostridia RepID=B0K4K8_THEPX Length = 429 Score = 471 bits (1214), Expect = e-131, Method: Composition-based stats. Identities = 129/422 (30%), Positives = 205/422 (48%), Gaps = 20/422 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + Y+ ++ I LGLE + + +G + + + VAGTNGKG+T + +IL Sbjct: 3 YEEAIGYIHGIYKFGIKLGLENIRKLLDYMGNPQKSLKIIHVAGTNGKGSTSAFISNILQ 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEY 126 AGYKV +Y+SP+L + ER+R+ G+ + + I+ G T FE Sbjct: 63 QAGYKVALYTSPYLEEFEERMRINGENISKEKLIYYVEYIKPIISRMVEEGYNHPTEFEV 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIG 185 T A F ++D V+LEVGLGGR DATN +D+ V+V+T+I DHTD LG I Sbjct: 123 VTAIAFKYFYDEKVDFVVLEVGLGGRFDATNAIDSSLVSVITTIDYDHTDRLGHTLGEIA 182 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS-DAH 242 EKAGI + + + +PE I + + + A L N + + + F + Sbjct: 183 YEKAGIIKQKGVVVSFYQQPEAMKVIIEACEVRNAYLTVLEKS-NVIIKEQNPDFQIFDY 241 Query: 243 GTLENLPLPLVPQPNAATALAA------LRASGLEVSENAIRDGIASAILPGRFQIVSES 296 ++L + L+ + A A L+ G E++E IR+G+ A PGR +++ + Sbjct: 242 KKYKDLKITLLGEHQIYNAALAIESVEKLKMYGYEITEKDIREGLYRAKWPGRLEVMRKK 301 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P V+ D AHNP L +K L K +++ VIGML DKD L + + Sbjct: 302 PYVVIDGAHNPQGMTVLKESLK-LFKYDKLILVIGMLKDKDTQKMLDIIVPEANMIITTT 360 Query: 357 LEGPRGATAEQLLEHLGNGK--SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 R A +L E + K + +++ +A A+ AK ED VL CGS + + +V ++ Sbjct: 361 PISERAYKASELAERIEKEKVIAIENIEEAVKYALDIAKEEDMVLFCGSLYMIGYVRSML 420 Query: 415 DA 416 Sbjct: 421 KK 422 >UniRef50_C6P114 FolC bifunctional protein n=1 Tax=Sideroxydans lithotrophicus ES-1 RepID=C6P114_9PROT Length = 456 Score = 468 bits (1204), Expect = e-130, Method: Composition-based stats. Identities = 203/450 (45%), Positives = 250/450 (55%), Gaps = 49/450 (10%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 S LA WLSYLE+LH KTI LGLERV V +L L+PA V V GTNGKG+ C LESI Sbjct: 3 STLADWLSYLESLHPKTIALGLERVEQVRRKL-NLQPAFPVIIVGGTNGKGSVCAMLESI 61 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L AAGYKVG Y+SPHL+ Y ERVR+ Q+ ++ ASFAEIE ARGDISLTYFE+GTL+ Sbjct: 62 LHAAGYKVGCYTSPHLLEYNERVRIAKQQASDAELCASFAEIEQARGDISLTYFEFGTLA 121 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ F Q+DV +LEVGLGGRLDA N+ DADVAVV S+ +DH D+LG RE I EKAG Sbjct: 122 AMQCFISHQVDVAVLEVGLGGRLDAVNVFDADVAVVASVDIDHVDYLGDTREKIAFEKAG 181 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD----------------- 233 IFR + AI + ++P + AQ A L G E+ + + Sbjct: 182 IFRQGRVAICADGDVPQALRQHAQAVAAELWCIGSEFGFQLPSPAGGGEGGGEAHVINVG 241 Query: 234 ------------------HDWAFSDAHGTLENLPLPLV----PQPNAATALAALRAS--G 269 W F GT +LP P + NA+ LA L A Sbjct: 242 QPLSLALSRSREREQKPMGQWNFYSKVGTRSSLPFPALRGAFQLHNASAVLAVLDALKDK 301 Query: 270 LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAV 329 L VS A+R G+ L GRFQ V P++I DVAHNPHAA L + ALP + AV Sbjct: 302 LPVSMEAVRRGLVEVQLAGRFQFVPGLPQLILDVAHNPHAARSLAQNLAALPP-AKTFAV 360 Query: 330 IGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL------GNGKSFDSVAQ 383 ML DKD+ G + L +D W A + PRGATA +L++ L G + S+A Sbjct: 361 FAMLKDKDMTGVVEALDGQIDVWLVAGITAPRGATAAELVQVLQDVQVRGEIQPCASIAD 420 Query: 384 AWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 A A A D + GSF+TVA VM V Sbjct: 421 AMHEASNRAGENDRIAAFGSFYTVAEVMRV 450 >UniRef50_A0LIV6 FolC bifunctional protein n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LIV6_SYNFM Length = 431 Score = 467 bits (1202), Expect = e-130, Method: Composition-based stats. Identities = 130/425 (30%), Positives = 202/425 (47%), Gaps = 15/425 (3%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 + S + YL L I GL + + RLG + +AGTNGKG+T Sbjct: 3 EMSLSEYQDSVDYLFGLQKHGIKFGLNSTNNLLMRLGNPHRSLRCIHIAGTNGKGSTAAM 62 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD-ISLTYFE 125 L S+L G +VG+Y+SPHLVR+TER R+ +E+ A F ++ D T+FE Sbjct: 63 LSSMLRKHGVRVGLYTSPHLVRFTERFRIDEREVRIDRILAIFEKVRKQIDDREPPTFFE 122 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T AL LF + ++ ++E G+GGRLDATN++ V+V+T++ DH ++LG SI Sbjct: 123 VVTAMALLLFAEENVEWAVIETGMGGRLDATNVIHPRVSVITNVTFDHQEYLGSTLSSIA 182 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWA-FSDAH 242 REKAGI + E P + G +P + + Q K A+L R G E+ A + Sbjct: 183 REKAGIIKEEVPVVTGVTQPLVHGVLTATCQRKRAVLYRLGKEFKARRRPGGAARYQGLK 242 Query: 243 GTLENLPLPL---VPQPNAATALAALRAS----GLEVSENAIRDGIASAILPGRFQIVSE 295 +L + L NAA A+A L + A+ G+++ P R +++ Sbjct: 243 WDWPSLEISLPGVHQVRNAALAIAVLEVLEEKGDFYIDSGAVELGLSAVRWPARLEVLGR 302 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 P ++ D AHNP AE L ++ ++ V+G++ DKDIAG L + + Sbjct: 303 RPLIVLDGAHNPQGAESLRDALRNCFTYQKLHLVMGIMEDKDIAGIFRRLLPLAETAIFT 362 Query: 356 PLEGPRGATAEQLLE----HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 R A A++L + + GN VA+A A A +D + + GS + V Sbjct: 363 QPRYSRAAKADRLRQLARPYAGNHCVIPDVAEAIQQAGRFAGPDDLICITGSLYFAGEVK 422 Query: 412 EVIDA 416 E+ Sbjct: 423 ELFGE 427 >UniRef50_C7N4J3 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N4J3_SLAHD Length = 427 Score = 464 bits (1195), Expect = e-129, Method: Composition-based stats. Identities = 125/415 (30%), Positives = 203/415 (48%), Gaps = 17/415 (4%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 +YL + LGLER++ + RLG + A V +AGTNGKG+T IL AAG++ Sbjct: 14 AYLNQSSWTQVKLGLERITTLLERLGHPEQAYPVVHIAGTNGKGSTSAFTAGILQAAGFR 73 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSALWLF 135 G+++SP+++ + ER++V + + ++ + A + T FE T A F Sbjct: 74 TGLFTSPYILEFNERIQVNRENIGDADLHDIALAVRQAADGLEEEPTPFELVTAVAFEYF 133 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 ++A+ D+V+LEVGLGGR DATN+ V +T IA+DH LG I EKAGI + Sbjct: 134 RRAECDIVVLEVGLGGRYDATNVTTPAVCAITPIAMDHVGVLGNTLAEIAGEKAGIIKPG 193 Query: 196 KPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV 253 P + +PE + I A+ GA + ++ + G + ++ L L+ Sbjct: 194 VPVVCYTQKPEAEAVIRAEARAIGAPVMTPRFGRIHARMEGLQQVFSYDG-INDVKLRLL 252 Query: 254 PQPNAATALAA------LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNP 307 A+ A LR G ++++ I+ G+ PGRF++V+ P I D HN Sbjct: 253 GAYQPCNAVMAIEIARTLRNQGFDIADEDIKRGLEETRWPGRFELVATDPVTIVDGGHNE 312 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC-APLEGPRGATAE 366 AE L ++ + V V+G+L DK + ++ + +YC P E R +AE Sbjct: 313 QGAEVLADSLRRYFPDTPVTFVMGVLKDKQYPQMINYVVPLAKRFYCATPPESERALSAE 372 Query: 367 QLLEHLGNGKSFD-----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 L + L + D S+A+A A A A +D V GS +++A +M ++ Sbjct: 373 DLAQALREAGAADARPCASIAEAVQTARAQAGPDDVVCCFGSLYSIATIMAALEG 427 >UniRef50_Q15VG0 FolC bifunctional protein n=1 Tax=Pseudoalteromonas atlantica T6c RepID=Q15VG0_PSEA6 Length = 426 Score = 464 bits (1194), Expect = e-129, Method: Composition-based stats. Identities = 179/417 (42%), Positives = 254/417 (60%), Gaps = 4/417 (0%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 I+ + A L WL +L LH K I++GLERV+ V +L + V TVAGTNGKGT Sbjct: 7 IQASSFEAWSLNEWLDHLSALHPKNIEMGLERVNKVFEQLNISFSKQTVVTVAGTNGKGT 66 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 TC LE +AAG +VGVYSSPHL++YTERVR+ G + E AH +F +E ARGDI LT Sbjct: 67 TCAFLEQACLAAGKRVGVYSSPHLIQYTERVRINGIDGSEQAHCRAFQAVERARGDIPLT 126 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+GTL+ L L A +D+ +LEVGLGGRLDA N+V D+AV+TSI LDH D+LG +E Sbjct: 127 YFEFGTLAGLKLVHDANVDIALLEVGLGGRLDAVNVVSPDIAVITSIDLDHQDFLGDTKE 186 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 + EKAGI R P +VGEP + D + AL + V+++Y + D +S+ Sbjct: 187 LVAAEKAGIMRDNIPVVVGEPVKYQALLDAVSQHSALASWQHVDFDYQLADDYMVWSNHQ 246 Query: 243 GTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 + LP+P +P N +T L ++ L++SE + + I LPGR Q + SP ++ D Sbjct: 247 LSYAQLPIPHIPAQNVSTGLQVIQLLKLDLSEGDLANVITDTRLPGRCQYIGYSPAIMVD 306 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 VAHNPHA YL +++ L + R+ V+GML DKDI +LA ++ W L+ PRG Sbjct: 307 VAHNPHATGYLLSQIRKLDYD-RLYLVVGMLKDKDIRSSLADFSNLNAHWMLGGLDVPRG 365 Query: 363 ATAEQLLEHLGNGK---SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 A A + L + F +V QA++ A A A+ +D ++V GSF TV+ ++++ + Sbjct: 366 AAAADIKSVLDEQQKVLEFSTVCQAFEKAKALAQEQDLIVVFGSFFTVSDILKLSNK 422 >UniRef50_C6AMR7 FolC bifunctional protein n=3 Tax=Pasteurellaceae RepID=C6AMR7_AGGAN Length = 448 Score = 463 bits (1193), Expect = e-129, Method: Composition-based stats. Identities = 222/446 (49%), Positives = 280/446 (62%), Gaps = 36/446 (8%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 ++ +A +PL WLSYLEN H K IDLGLERV VA L +L PAP+V TV GTNGKGT Sbjct: 1 MQTELKATTPLNEWLSYLENSHFKAIDLGLERVKSVAQELDLLTPAPYVITVGGTNGKGT 60 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 TCR LE+IL+ AGY VGVYSSPHL+RY ERVR+Q QEL ++ HTASFA IE+ + SLT Sbjct: 61 TCRLLETILLNAGYSVGVYSSPHLLRYNERVRIQNQELDDAQHTASFAYIEAHKSQ-SLT 119 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+ TLSAL LFK A+LDVVILEVGLGGRLDATNIVD +AV+TSI +DHTD+LG RE Sbjct: 120 YFEFSTLSALHLFKCAKLDVVILEVGLGGRLDATNIVDNHMAVITSIDIDHTDFLGSTRE 179 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 IG EKAGIFR+ KP I+GEP +P + D A + G+ R ++W +S W + Sbjct: 180 QIGFEKAGIFRANKPVIIGEPMIPQAMLDRANQLGSQHFCRHLDWTFSQQGQSWTWQTTQ 239 Query: 243 -------GTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQI--- 292 L +LPL +P NAATALAA++ E+S + ++ +A L GRFQ Sbjct: 240 SDEKVRWNFLTDLPLCQIPLANAATALAAVQKLPFEISLDVVKKSLAEVELIGRFQTLKP 299 Query: 293 -------------VSESPRVIFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKD 337 VS+ P++I DV HNPHAA YL ++ AL NG+ +AV GML DKD Sbjct: 300 ECLAHLAQKLNRHVSQLPQMIIDVGHNPHAARYLAEKLTALKAQSNGKFIAVCGMLKDKD 359 Query: 338 IAGTLAWLKSVVDDWYCAPLEGPRGATAEQLL----------EHLGNGKSFDSVAQAWDA 387 G L L ++D+W C L G RG T EQL + + G +SVA+ + Sbjct: 360 AEGVLEPLLPLIDEWRCVTLGGYRGQTGEQLFVTLQQTARLHQKVVKGSYSNSVAEGVKS 419 Query: 388 AMADAKAEDTVLVCGSFHTVAHVMEV 413 A+ + DT+LV GSFHTV + Sbjct: 420 AVEISNENDTLLVFGSFHTVGEFLTY 445 >UniRef50_A6VWY8 FolC bifunctional protein n=2 Tax=Marinomonas RepID=A6VWY8_MARMS Length = 418 Score = 463 bits (1192), Expect = e-129, Method: Composition-based stats. Identities = 192/414 (46%), Positives = 254/414 (61%), Gaps = 11/414 (2%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 A + LASWLSY+E+ H I+LGLER S V ARL + +P V TVAGTNGKG+TC L Sbjct: 2 AHTSLASWLSYIESQHPSEIELGLERGSKVLARLNLSRPKHKVITVAGTNGKGSTCAMLT 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 L A Y VG Y+SPH + + ER+ + + +F +E AR ISLTYFE+ T Sbjct: 62 QYLCAQNYSVGTYTSPHFIAFNERIALNDSPCDDEVLCRAFEVVEEAREGISLTYFEFST 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+ALW+F Q+ LD +LEVGLGGRLD+ N++D DVAVVTSI+LDH DWLG + + I REK Sbjct: 122 LAALWIFDQSNLDYWVLEVGLGGRLDSVNMMDTDVAVVTSISLDHIDWLGDNLDVIAREK 181 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 AGI R +K I G PSTIA A E GA L+++GV++++ + W++S E L Sbjct: 182 AGIARKDKLLISGVVNPPSTIASTALEVGAHLRQKGVDFHFELDGSTWSWSGDGVQFEKL 241 Query: 249 PLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPH 308 P+P +P NAAT +A L G + + SA L GRFQ V+ SP V DVAHNP Sbjct: 242 PIPALPLQNAATVIAVLVYMGFSPAYADLVTLFDSAQLMGRFQKVATSPDVYIDVAHNPE 301 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 AA L R+ LP + +AV GML DKDIA + L DW+C L GPRGA A +L Sbjct: 302 AAIELAQRISNLP--IQPVAVCGMLKDKDIASVMEHLAGSFSDWFCCDLAGPRGAKASEL 359 Query: 369 LEHLG--------NGKSFDSVAQAWDAAMADAKAEDT-VLVCGSFHTVAHVMEV 413 ++H+ N K+F SV A+ +A+ A+ E V+V GSF TV++ + + Sbjct: 360 IKHIVHSSPSLALNAKAFQSVGDAFSSALVKAQDEQRSVIVFGSFVTVSNYLAL 413 >UniRef50_C6MBR5 FolC bifunctional protein n=1 Tax=Nitrosomonas sp. AL212 RepID=C6MBR5_9PROT Length = 432 Score = 462 bits (1191), Expect = e-129, Method: Composition-based stats. Identities = 173/420 (41%), Positives = 245/420 (58%), Gaps = 16/420 (3%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 WLSY E H +TI+LGL+R++L+ + L L P + V GTNGKG+ C LESIL A Sbjct: 13 DWLSYFEAFHPQTIELGLDRINLIRSEL-ALHPQFPIIIVGGTNGKGSVCAMLESILYCA 71 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA--RGDISLTYFEYGTLSAL 132 GY+VG Y+SPHL+ Y ER+R+ + + + +F +I SA DISLTYFE GTL+A+ Sbjct: 72 GYEVGCYTSPHLLHYNERIRISKKNIDDQRLCNAFMQIYSACKVRDISLTYFEVGTLAAM 131 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 + F QA ++ +LEVGLGGRLDA NI DAD +++TS+ LDH D+LG RE IG EKA IF Sbjct: 132 YCFVQAGVNAAVLEVGLGGRLDAVNIFDADCSILTSVDLDHIDYLGDTREKIGFEKAAIF 191 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 R KPAI E ++P ++ A+ A+L R + + + W F +LP P Sbjct: 192 RKNKPAICAEIDLPQSVIQQAENNDAILYRINKHFGFLKQEMHWDFWGPRNKRYSLPFPA 251 Query: 253 V----PQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 + NA+T LAAL L VS + +R G+ A++ GRFQ+VS P +I DVAHN Sbjct: 252 LRGEKQLQNASTCLAALDTLEETLPVSMSNVRQGLIEAVISGRFQVVSTQPFIILDVAHN 311 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 P AA L+ ++A G+ A++ ML DKDI G + LK+ +D W+ + ++ R A A+ Sbjct: 312 PGAAMVLSQNLRATRPTGQTFAIMAMLQDKDIRGVIQALKNDMDYWFVSSVDASRAAAAD 371 Query: 367 QLLEHLGNG-------KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 L+ L + F A+ A A D + V GSF+TV V+ ++ +S Sbjct: 372 YLINELYEAEVANDRIRKFSDTISAFVFACEQAGKNDRICVFGSFYTVGDVLRYLNTHQS 431 >UniRef50_Q492H5 Folylpolyglutamate synthase n=3 Tax=Enterobacteriaceae RepID=Q492H5_BLOPB Length = 424 Score = 462 bits (1190), Expect = e-129, Method: Composition-based stats. Identities = 210/419 (50%), Positives = 281/419 (67%), Gaps = 7/419 (1%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 I TP S L WL+Y+E+L IDL L+RV +A LG++ PA +V V GTNGKGT Sbjct: 4 IFHTPPERSSLGKWLNYIESLSHVLIDLNLDRVRKIAINLGLMHPAEYVILVGGTNGKGT 63 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 TC LE+IL+ VG+Y+SPHL+ Y ER+RV G+ELP+S H + + IES R I+LT Sbjct: 64 TCCLLETILLNNNNTVGLYTSPHLLSYNERIRVCGKELPDSIHIEALSVIESVRHHIALT 123 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+ TLSAL++FK+A+LDVVILEVGLGGRLDATNIV+ D++V+T+ A+DHTD+LG +R+ Sbjct: 124 YFEFITLSALYIFKRAKLDVVILEVGLGGRLDATNIVNPDISVITNFAIDHTDFLGINRD 183 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF---S 239 I +EK+GIFR KPA++GE P +AQ GA+L RG +WN+ V + W + S Sbjct: 184 MIAQEKSGIFRFNKPAVIGESCFPVIARKMAQYCGAMLFARGRDWNFRVYGNKWIWWECS 243 Query: 240 DAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 + + L +LPLP++P NAATAL+ L V + AI G+ A LPGRFQIV+ P Sbjct: 244 NEYKLLYDLPLPIIPIENAATALSVLYWLPFLVDKTAISYGLQVATLPGRFQIVTRRPIA 303 Query: 300 IFDVAHNPHAAEYLTGRMKALPKN--GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 I DV HNPHAA YLT R+ L K G+V VIGML +KDI GT+ L +VD WYC+ L Sbjct: 304 ILDVGHNPHAANYLTKRLPVLLKRRTGKVRMVIGMLKNKDIQGTIYCLSHLVDVWYCSDL 363 Query: 358 EGPRGATAEQLLEHL--GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 P A++ +L + L N + F ++ AW+ A+ DA +D +LV GSFH V+ +M I Sbjct: 364 NVPFSASSVELSDCLLHCNVQIFSNILDAWNQAVLDASFDDCILVFGSFHAVSPIMRNI 422 >UniRef50_B8FMP6 FolC bifunctional protein n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FMP6_DESAA Length = 444 Score = 462 bits (1189), Expect = e-128, Method: Composition-based stats. Identities = 128/418 (30%), Positives = 201/418 (48%), Gaps = 14/418 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + L +L I LGLE + + +G +AGTNGKG+ + SIL Sbjct: 7 FNQAMEELFSLGRFGIKLGLETILAMLKGIGDPHLRIQCIHIAGTNGKGSVAQNTASILQ 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-DISLTYFEYGTLSA 131 AAGYKVGVY+SPHLV ER V G+ + + ++ ++S G + T+FEY T A Sbjct: 67 AAGYKVGVYTSPHLVHINERFTVNGRPISDDEVLEAYQAVKSVSGLERHATFFEYTTAMA 126 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 L+ F +A +D ++E G+GGRLDATN++ ++ ++T+I+++H +LG I EKAGI Sbjct: 127 LYAFDRAGVDYAVMETGMGGRLDATNVLKPELCIITNISVEHEMYLGNTIAQIAYEKAGI 186 Query: 192 FRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY-SVTDHDWAFSDAHGTLENL 248 + P + G +P+ + A E A L R G ++ + + F + L Sbjct: 187 IKPGVPVVTGVRQPDAIKAVEKAAAESKAPLYRMGKDFKTRRLQGGGFNFYGQDHAWKGL 246 Query: 249 PLPL---VPQPNAATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 L PNA+ ALA AL G +++E + G+ PGR + + ESP VI D Sbjct: 247 QCRLKGEYQIPNASLALAGCQALTKRGAKITEEQAKAGLEQVKWPGRLETIQESPMVILD 306 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 AHN A + LT + + V + G L DK L L+++ + R Sbjct: 307 GAHNLAAMKVLTKYLAETFADRDVTVITGFLDDKPYKKMLPMLEALAAKIIITRPKIGRA 366 Query: 363 ATAEQLLEHLGNGK----SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 ++L + N K SV +A A+ +A+ D ++V GS + V + + Sbjct: 367 VETKELTPLIRNKKDRFVEKPSVEEAVKYALENARDTDVIVVAGSLYIVGEARQTLQD 424 >UniRef50_A5IBI5 FolC bifunctional protein n=4 Tax=Legionella pneumophila RepID=A5IBI5_LEGPC Length = 428 Score = 461 bits (1186), Expect = e-128, Method: Composition-based stats. Identities = 163/426 (38%), Positives = 241/426 (56%), Gaps = 11/426 (2%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 TP + L WL++LE +++ I LGL RV VA +L + +P V TVAGTNGKG+T Sbjct: 2 HTPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGSTV 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 LE+I +G++VG Y+SPHL+ + ER+R+ + + +F+ IE AR +LTYF Sbjct: 62 TALETIYHQSGFRVGTYTSPHLLVFNERIRINLTPIQDKDLCKAFSVIEEARYPTNLTYF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E TL+ALW FKQ LD++ILEVGLGGRLDATNIVD D+A++T+I DH ++LG E I Sbjct: 122 EMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDLAIITTIDFDHQNFLGDTLELI 181 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 G EKAGI R KP I + P ++ +VA + GA G ++ Y W + Sbjct: 182 GYEKAGILRKNKPFIYADLSPPKSVVEVALQLGASSYLYGKDYFYQEEADHWEVTCQGKP 241 Query: 245 LENLPLPLVPQPNAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 E L P + +AA A+ A L + L VS ++ + +PGR Q+ +++D Sbjct: 242 FEQLTRPKIQLRSAAAAVMACHLMQNDLPVSYKNLKKAMELIYIPGRLQLQKGKTDILYD 301 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 V+HNP + L +K + G++ AV L DKD+ G + L+ V+ WY A L R Sbjct: 302 VSHNPQSVRLLADTIKKINVKGQIHAVFSALKDKDLYGLIMPLRDCVNRWYPAQLHNKRA 361 Query: 363 ATAEQLLEHLGNGKSFDSVA-----QAWDAAMADAKAEDTVLVCGSFHTVAHVM----EV 413 A+ E+LL + F V A++ A+ A +D ++V GSF TV+HVM + Sbjct: 362 ASQEELLSVFREAEIFLDVCYNDPFTAFEMALKQASDDDLIIVYGSFFTVSHVMAAQHNL 421 Query: 414 IDARRS 419 ++ + + Sbjct: 422 LEQKEN 427 >UniRef50_Q5QWH7 Folylpolyglutamate synthase n=2 Tax=Idiomarina RepID=Q5QWH7_IDILO Length = 430 Score = 460 bits (1184), Expect = e-128, Method: Composition-based stats. Identities = 208/426 (48%), Positives = 264/426 (61%), Gaps = 11/426 (2%) Query: 2 IIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 I P + L WL+YLE LH K ID+GLERV+ VAA GVLKPA V TV+GTNGKG Sbjct: 4 ISSSAPAVTASLQEWLTYLEKLHPKNIDMGLERVARVAANAGVLKPAALVITVSGTNGKG 63 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL 121 +T LE+IL AAGY GVY+SPH+ Y ERVRV QELP+S H +F IE AR + SL Sbjct: 64 STVCYLETILQAAGYTTGVYTSPHITEYRERVRVNAQELPDSEHVKAFHAIEQARNNTSL 123 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 TYFE+GTL+ALWL + DV ILEVGLGGRLDA N VDADVAVVTSI +DH +LG +R Sbjct: 124 TYFEFGTLAALWLMGRQSPDVAILEVGLGGRLDAVNCVDADVAVVTSIGIDHIAFLGNNR 183 Query: 182 ESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 E IG EKAGI RS KP I GE ++IA+ A+ GA L + G +++ + D W++ Sbjct: 184 EHIGYEKAGIARSGKPLICGEASPTASIAESAERIGAKLYQVGRDFHRTEYDESWSYRSQ 243 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP-RVI 300 + L +LPLP +P NA+TA+AA+ L VS +AIR+GI A LPGR Q + + V+ Sbjct: 244 NTQLNDLPLPKLPLINASTAIAAIEQLPLPVSLSAIREGITQASLPGRMQPDTVNGIEVL 303 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHNP AA Y + + ++ AV+GML DKD AG L S WY L P Sbjct: 304 LDVAHNPQAAVYASRYLNKFYPQHKIFAVVGMLSDKDHAGVANALSSQASAWYLGSLSEP 363 Query: 361 RGATAEQLLEHLG----NGKSFDSVAQAWDAAMADA------KAEDTVLVCGSFHTVAHV 410 RG TA+ L+ + + F+SV QA+ AA+ A + V GSF+TVA + Sbjct: 364 RGETADNLVINAKLPTESCYLFESVEQAFAAAVTAAQQWQMNDGKALVFGFGSFYTVARI 423 Query: 411 MEVIDA 416 + Sbjct: 424 NAYLKG 429 >UniRef50_A8PMD7 FolC bifunctional protein n=1 Tax=Rickettsiella grylli RepID=A8PMD7_9COXI Length = 430 Score = 458 bits (1180), Expect = e-127, Method: Composition-based stats. Identities = 176/418 (42%), Positives = 249/418 (59%), Gaps = 9/418 (2%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 + L+ WLSY+E LH ++ GLER+S VA L +L + TVAGTNGKG+ L Sbjct: 11 DSRQLSDWLSYIETLHPHRMEFGLERISHVAENLNLLHFDCPIVTVAGTNGKGSNVGLLA 70 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 +IL AGY+VG Y+SPHL Y ER+RV Q + + +F ++E R SLTYFEYGT Sbjct: 71 AILSVAGYRVGTYTSPHLRHYHERIRVGSQCISDQDLCHAFFQVEKKRLGTSLTYFEYGT 130 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+AL+ FKQ LD++ILEVGLGGRLDA N VDAD++++++IA+DHT WLG RE IG EK Sbjct: 131 LAALYYFKQVPLDLIILEVGLGGRLDAVNCVDADLSIISTIAIDHTQWLGKTREKIGLEK 190 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 A I R+ +P + G+ P+++ + A+ + L R GVE++Y + W++ +L +L Sbjct: 191 AAIMRAYRPCVCGDFSPPTSVLNTAKSLNSPLYRLGVEFDYKMQHSSWSWQSRKRSLHHL 250 Query: 249 PLPLVPQPNAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPR-VIFDVAH 305 PLP + NAAT L A L + ++ AI++G+ +PGRF I+ ++ R +I DVAH Sbjct: 251 PLPTIDLQNAATVLQAVELLSERFTIASFAIQEGLKRVFVPGRFHIIEKNARQIIVDVAH 310 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATA 365 NP L+ R+ P G A+ GM+ DKDI T L + VD WY L RGA A Sbjct: 311 NPAGGVCLSKRLANTPCLGETYALAGMMADKDITNTFRPLSNHVDYWYLCDLTEHRGAKA 370 Query: 366 EQLLEHLGNGK------SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 QL + L + K F S A+ A + + D +L+ GSFHT A + ++ Sbjct: 371 TQLKQSLLDLKVKQSILEFSSPEFAFQRAFSQLRKNDRLLIFGSFHTAAAIYHYLERE 428 >UniRef50_Q3JCB5 Folylpolyglutamate synthetase n=3 Tax=Gammaproteobacteria RepID=Q3JCB5_NITOC Length = 432 Score = 457 bits (1178), Expect = e-127, Method: Composition-based stats. Identities = 189/411 (45%), Positives = 263/411 (63%), Gaps = 8/411 (1%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 S L+ WL + E H +D L R S V R+ + P + T+AGTNGKG+T LE+I Sbjct: 5 SRLSDWLRWQETAHWPRVDPSLIRASAVLQRMVLSTPPFPIVTIAGTNGKGSTVALLEAI 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L+AAGY+VG Y+SPHL+RY ER+++QG+ + + SFA I++AR +ISLTYFE+GTL+ Sbjct: 65 LLAAGYRVGSYTSPHLLRYNERIKIQGEAVSDDIICQSFARIDAARHEISLTYFEFGTLA 124 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ +F QA LD+ +LEVGLGGRLDA N +DADVAV+T++ +DH ++LGPDRESIG EKAG Sbjct: 125 AIDIFHQAGLDIALLEVGLGGRLDAVNALDADVAVITTVDIDHINFLGPDRESIGFEKAG 184 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 IFRS +PAI G+PE P ++ A+E L R G +++Y + W++ +LP Sbjct: 185 IFRSHRPAICGDPEPPESVLAHAKESSVPLYRIGRDFHYQMAGEGWSWWSNGSHYADLPH 244 Query: 251 PLVPQPNA----ATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 P + A AL AL+ A+ L VSE AIRDG+++ LPGRFQ + IFDVA Sbjct: 245 PALQGACQYQNGAAALMALKLMAARLPVSETAIRDGLSAVRLPGRFQCLPGEMERIFDVA 304 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HN A +L + P GR AV+GML DKD+AG ++ L++ + W+ L RG + Sbjct: 305 HNLQGARWLARSLTDRPCGGRTYAVLGMLADKDVAGVVSVLENAIHGWFVGGLAVDRGLS 364 Query: 365 AEQLLEHLGNGKS--FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 + L E +G+ + SVA+A+ AA+ A+ D VL GSFHTV VM + Sbjct: 365 GQALAERMGHLTPAIYQSVAEAYRAALEAAQPGDRVLAFGSFHTVEAVMRL 415 >UniRef50_B0UU80 FolC bifunctional protein n=14 Tax=Pasteurellaceae RepID=B0UU80_HAES2 Length = 443 Score = 457 bits (1178), Expect = e-127, Method: Composition-based stats. Identities = 205/444 (46%), Positives = 281/444 (63%), Gaps = 31/444 (6%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M+ A SPL WL +LE H+K IDLGL+RV VA +L +L+PAPFV TV GTNGK Sbjct: 1 MMSSLNLFATSPLEQWLCFLEKAHAKAIDLGLDRVKTVAQQLDLLQPAPFVITVGGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 GTTCR LE +L+ +G++VGVYSSPHL+RY ERVR+Q QEL + HT +FA IE + S Sbjct: 61 GTTCRLLEILLLNSGFRVGVYSSPHLIRYNERVRIQNQELADEEHTQAFAFIEQHKSQ-S 119 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 LTYFE+ TLSAL+LFKQA LDVVILEVGLGGRLDATNIVDAD+AV+TSI +DHTD+LG Sbjct: 120 LTYFEFSTLSALYLFKQANLDVVILEVGLGGRLDATNIVDADLAVITSIDIDHTDFLGNT 179 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD 240 RE I EK+GIFR KPA++GE +P ++ + ++ ++L R +W +S ++ W + Sbjct: 180 REEIAFEKSGIFRPNKPAVIGENNIPCSLLEQGKKLDSILFCRNKDWKFSKQENGWTWET 239 Query: 241 AHG----TLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 G ++NLP+ +P NAATALA L ++S + I + L GRFQ ++ Sbjct: 240 IKGNKAIYMDNLPICSIPLANAATALATLAYLPFDISISVIHKSLREVELAGRFQKINPE 299 Query: 297 ----------------PRVIFDVAHNPHAAEYLTGRMKALPKN--GRVLAVIGMLHDKDI 338 P++I DV HNPHAA YL R+ AL G++++V G+L DKD Sbjct: 300 KLLNLAKLSKKTVKQLPQIIVDVGHNPHAASYLLERLTALKAKSIGKIISVCGILKDKDS 359 Query: 339 AGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN--------GKSFDSVAQAWDAAMA 390 G L+ L VVD W L+G RG ++ +L L +++ SV + +A+ Sbjct: 360 QGILSPLIKVVDQWNLVTLDGVRGQSSHELFMTLQQISTTNELSAQTYSSVYEGVKSAVQ 419 Query: 391 DAKAEDTVLVCGSFHTVAHVMEVI 414 +A +D +LV GSF+TV ++++ Sbjct: 420 NATEKDIILVFGSFYTVGSFLKLL 443 >UniRef50_Q88LD8 Folylpolyglutamate synthetase n=23 Tax=Pseudomonadaceae RepID=Q88LD8_PSEPK Length = 436 Score = 457 bits (1176), Expect = e-127, Method: Composition-based stats. Identities = 199/424 (46%), Positives = 258/424 (60%), Gaps = 14/424 (3%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L WL+YLE LH ID+GLER V ARL + K AP V TV GTNGKG+TC + S+L Sbjct: 6 SLGEWLAYLEQLHPSAIDMGLERSQKVLARLALGKLAPRVVTVTGTNGKGSTCAFVASLL 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 A G KVGVYSSPHL+RY ERV + GQE + +FA +E+ARGDISLTYFE GTL+A Sbjct: 66 RAQGLKVGVYSSPHLLRYNERVVIDGQEASDERLCEAFAAVEAARGDISLTYFEMGTLAA 125 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 WLF Q+QLD V+LEVGLGGRLD N+VDAD A+VTSI +DH D+LG RE + EKAGI Sbjct: 126 FWLFYQSQLDAVVLEVGLGGRLDTVNVVDADFALVTSIGVDHVDYLGDTRELVAFEKAGI 185 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS-----DAHGTLE 246 FR KPA+ G+ + P + D A E A L RG E++ + + W++ A L Sbjct: 186 FRPGKPALCGDLDPPGPLLDKAAELAAPLFLRGREFDLASAEGCWSWRGTAADGAQVELR 245 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS-----ESPRVIF 301 +LPL +P NA AL A GL + +R + + GR + + + ++ Sbjct: 246 DLPLLDLPMENATLALQAFLLMGLPWNAAQVRQALLDTRITGRLDLRNVNWQGKPVALLL 305 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 DV HNPHAA+YL R+ A P GR LAV G+L DKD+ G +A L+ ++DDW APL+ PR Sbjct: 306 DVGHNPHAAQYLARRLAARPLKGRRLAVFGLLADKDLEGVIAPLQGLIDDWAVAPLDTPR 365 Query: 362 GATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 A +L L N KS+ SV A + A A A+D +L+ GSF VA +E ++ Sbjct: 366 SRPAAELASSLANLGATVKSYVSVDAALEGQCAQATADDQILLFGSFFCVAQALEWLERH 425 Query: 418 RSGG 421 G Sbjct: 426 AQEG 429 >UniRef50_A4XL37 FolC bifunctional protein n=5 Tax=Clostridia RepID=A4XL37_CALS8 Length = 431 Score = 456 bits (1174), Expect = e-127, Method: Composition-based stats. Identities = 123/428 (28%), Positives = 199/428 (46%), Gaps = 21/428 (4%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + L Y+ + + LGLE + + +G + + VAGTNGKG+TC + Sbjct: 2 SMTYEEALEYIHGTYKFGVKLGLENIKKLLELMGNPQKDLRIVHVAGTNGKGSTCAFINQ 61 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTY 123 +L+ AGYKVG+Y+SP+L + ER+++ + ++ +G T Sbjct: 62 MLIEAGYKVGLYTSPYLEFFNERIKINNIPISNDELATITEFVKDKVDLMISQGFNHPTE 121 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRE 182 FE T A FK+ +D V+LEVGLGGR DATN+V+ ++ ++TSI DH D LG E Sbjct: 122 FEIVTAIAFEYFKRTNVDFVVLEVGLGGRFDATNVVETPELCIITSIGYDHMDILGQTIE 181 Query: 183 SIGREKAGIFRSEKPAIVGEP---EMPSTIADVAQEKGALLQRRGVEWNY---SVTDHDW 236 I EKAGI + I+G E I+ V ++K A L ++ ++ + Sbjct: 182 QIAYEKAGIIKESSTVILGLQRYKEAIDVISKVCKQKNANLIEVKSDYKIIKNTLDGIVF 241 Query: 237 AFSDAHGTLENLPLPLVPQPNAATALAALRAS-----GLEVSENAIRDGIASAILPGRFQ 291 + G +NL + L+ AL + A +S A+ G+ +A GRF+ Sbjct: 242 DCTTPKGIYKNLEINLLGVHQVENALNCIYAFEYLSDKYNISTIALVKGLLNAKWNGRFE 301 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 I+S+ P VI D AHN L K K+ ++ AV+G+L DK+ L+ +K V D Sbjct: 302 IISKEPLVILDGAHNIDGMRVLVDSCKQYLKDKKISAVVGILKDKEYKKMLSMIKEVTSD 361 Query: 352 WYCAPLEGP-RGATAEQLLEHLGN--GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 + R + + E + +A D ++ A+ + +L+CGS + V Sbjct: 362 VIFTLVPYQKRAFSPAEAKEAALKFGFEFIKDYKEAIDVSLKKAEKDTAILICGSLYLVG 421 Query: 409 HVMEVIDA 416 I + Sbjct: 422 AARTYIKS 429 >UniRef50_Q0AGX2 FolC bifunctional protein n=1 Tax=Nitrosomonas eutropha C91 RepID=Q0AGX2_NITEC Length = 428 Score = 456 bits (1173), Expect = e-127, Method: Composition-based stats. Identities = 191/419 (45%), Positives = 255/419 (60%), Gaps = 19/419 (4%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + L WL YLE LH K ID+GLERV V LG++ P V TVAGTNGKG+ C LES Sbjct: 6 SMTLDDWLLYLEKLHPKAIDMGLERVKKVRDALGLM-PKFPVITVAGTNGKGSVCTILES 64 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYG 127 IL A Y+VG Y+SPHL+ Y ER+R+ + + + FAEIES R ++LTYFE+G Sbjct: 65 ILGRASYRVGCYTSPHLLHYGERIRIDQRAITDEVLCGVFAEIESVRESVQVTLTYFEFG 124 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 TL+A+ +F +AQ+DV ILEVGLGGRLDA N+ D D A++TSI LDH D+LG RE+IG+E Sbjct: 125 TLAAMLIFVRAQVDVAILEVGLGGRLDAVNVFDTDCAILTSIDLDHMDYLGSTREAIGQE 184 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 K GIFR KPAI EP++P+ + + GALL + Y+ + W + N Sbjct: 185 KIGIFRPNKPAICTEPDIPAGLLPKMKATGALLCCINKNFGYTQDNLQWCYEGVRRY--N 242 Query: 248 LPLPL------VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 L LP + +AA A L V NAIR G+A A L GRFQI+S P +I Sbjct: 243 LSLPALKGEYQLQNASAALAALEAMEGTLPVPMNAIRRGLAEATLAGRFQIISARPVIIL 302 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 DVAHNP A L ++A+P G A++GML DKD+AGT+ LK+ VD W A L+ R Sbjct: 303 DVAHNPAATRKLLANLEAMPVKGCTYAIVGMLKDKDMAGTIRVLKNNVDQWLIAGLDVAR 362 Query: 362 GATAEQLLEHLGNG--------KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 GAT ++L+ LG+ + F +V A+ A A ++D + V GSFHTV+ +++ Sbjct: 363 GATGNEILKALGDAGIAEQECVRVFQNVQSAYVYAREHAGSDDRICVFGSFHTVSSILK 421 >UniRef50_C6N083 FolC bifunctional protein n=2 Tax=Legionella RepID=C6N083_9GAMM Length = 429 Score = 455 bits (1172), Expect = e-126, Method: Composition-based stats. Identities = 170/419 (40%), Positives = 239/419 (57%), Gaps = 7/419 (1%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P LA WLS LE +++ I LGL R+ VA +L + V TVAGTNGKG+T Sbjct: 4 PYNEWDLAKWLSALETRNTQEIQLGLTRIQEVAQKLKLQNTECRVITVAGTNGKGSTVTA 63 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 LE I AGYKVG Y+SPHL+++ ER+RV + + +F IE+ARG I LTYFE Sbjct: 64 LEHIYHTAGYKVGTYTSPHLIQFNERIRVGLTPISDHDLCMAFRTIEAARGQIILTYFEM 123 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 TL+AL FKQA LD++ILEVGLGGRLDATN++DAD++++T+I DH D+LG ++IG Sbjct: 124 TTLAALLYFKQACLDLIILEVGLGGRLDATNVIDADLSIITTIDFDHQDFLGTTLDAIGY 183 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 EKAGI R KP I + P+TI DVA + E++++ W+ L Sbjct: 184 EKAGILRQRKPFIYADVNPPATIVDVASKLFCPTYFFNQEYSFAEQKASWSIYCGDHQLN 243 Query: 247 NLPLPLVPQPNAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 NLP P + +AA A+ A L A L V+ ++ + +PGR Q+ +++DV+ Sbjct: 244 NLPKPSIQLKSAAAAIMAVFLLARDLPVAFEQVQAAMRQIFIPGRLQLQKGPVSILYDVS 303 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HN +A+ L + +L GR+ AV L DKDI G + LK+ VD WY A L R + Sbjct: 304 HNAQSAKLLADTLYSLDSKGRIHAVFSALKDKDILGLIEPLKNCVDRWYPAQLGVKRAVS 363 Query: 365 AEQLLEHLGNGKSFDSVAQ-----AWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 A LL + + + + A++ A+ A+ D ++V GSF TV HV+ RR Sbjct: 364 ANLLLSYFKKAEIYVEICYNNPLLAFETALNQAEPGDLIVVYGSFFTVGHVLAAKPNRR 422 >UniRef50_C1D9J6 FolC n=26 Tax=Neisseriaceae RepID=C1D9J6_LARHH Length = 424 Score = 455 bits (1172), Expect = e-126, Method: Composition-based stats. Identities = 175/413 (42%), Positives = 232/413 (56%), Gaps = 14/413 (3%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + LA WLS+LE+LH +IDLGLERV V + L+P V TV GTNGKG+ C L I Sbjct: 5 TTLAGWLSHLESLHLSSIDLGLERVRQVVDAM-PLRPGFPVITVGGTNGKGSVCAMLTRI 63 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L +AGY+VG Y+SPHL+ Y ER+ + + L + A A +E+ RGD+ LTYFE+GTL+ Sbjct: 64 LASAGYRVGTYTSPHLMVYNERIAIDAESLSDEAIVRGLAAVEAGRGDVPLTYFEFGTLA 123 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+W F A++DV ILEVGLGGRLDA N+ + D A V S+ LDH DWLG +RE IG EKAG Sbjct: 124 AMWNFVDAKVDVAILEVGLGGRLDAVNVFEPDCAAVVSVDLDHQDWLGDNREDIGFEKAG 183 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-HDWAFSDAHGTLENLP 249 IFR+ KPA+ +P+ P+ + A GA L G ++ ++ TD W F LP Sbjct: 184 IFRAGKPALCADPQPPARLVGHAAAIGAPLWLAGRDFGFTRTDPLQWEFWCGQSRRHALP 243 Query: 250 LPLV----PQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 P + NAA LA L A L V A+R G+ P RFQ++ P + DV Sbjct: 244 TPALRGNYQMGNAALVLAILEAVRDRLPVGAGAVRRGLLEVEWPARFQVLPGRPVTVLDV 303 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRG 362 HNPHA + ++ L R LAV ML DKD+ + K D+W+ AP+ + PR Sbjct: 304 GHNPHAIRAMVSSLQTLNYAERRLAVFSMLADKDVDSVIELAKDEFDEWWVAPIADSPRA 363 Query: 363 ATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 L+ L +A A+ A A D + V GSFHTVA + Sbjct: 364 MPVAGLVARLRAHGVTRIHECADLATAYRQAREQATENDRITVFGSFHTVAAI 416 >UniRef50_B8DZV7 FolC bifunctional protein n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8DZV7_DICTD Length = 443 Score = 454 bits (1170), Expect = e-126, Method: Composition-based stats. Identities = 129/434 (29%), Positives = 198/434 (45%), Gaps = 27/434 (6%) Query: 8 QAASPLASWLSY---LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 + + L S+++Y L+N+ + LER+ + +G + F VAGT GKG+T Sbjct: 5 ERLNYLNSFINYEKRLDNITYEEKKFYLERMRYLLKLMGNPQDNLQAFHVAGTKGKGSTS 64 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAE----IESARGDI- 119 + SIL AGYKVG+Y+SPHL ER+ + + IE A+ Sbjct: 65 AMIFSILKEAGYKVGLYTSPHLQSIRERISTHKGFISQEEFIDLIDYAKPYIEEAKKHPI 124 Query: 120 --SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWL 177 T+FE T A F +LD V++EVGLGGRLDATN+++ V+++T I DH L Sbjct: 125 FGPPTFFEVLTALAFLYFYIKKLDYVVIEVGLGGRLDATNVINPLVSIITPIGFDHMHIL 184 Query: 178 GPDRESIGREKAGIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD 235 G E I EKAGI + K I + + E IA VA+E+ A+ + + + D Sbjct: 185 GNTIEKIAFEKAGIIKEGKFVISSIQKEEAEKVIAKVAKERNAIYYKIDNLFKWERKDFS 244 Query: 236 WA----FSDAHGTLENLPLPLVPQPNAATALAA-----LRASGLEVSENAIRDGIASAIL 286 E +PL+ + A+ A L L + +R+G Sbjct: 245 LNGQRFLLSGKDINEEFFIPLLGEHQIVNAITAFGAIYLLRDKLSIDYETVREGFKKVQW 304 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 GRFQIVS+SP I D AHN +A L +K R+ + G++ DKD G L L Sbjct: 305 MGRFQIVSKSPLTIIDGAHNVESAIALRDTLKNYVNFNRLFLICGLMKDKDAEGFLKILN 364 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVA------QAWDAAMADAKAEDTVLV 400 +V + PL R + E+L + + + ++ +A + +A ED +L+ Sbjct: 365 PLVYSYNFVPLSSHRTRSPEELGNIVKSFNADANINLHTNFYEAINFVKKEASPEDLILI 424 Query: 401 CGSFHTVAHVMEVI 414 GS + + Sbjct: 425 TGSLYLAGEALNYF 438 >UniRef50_B5YD69 Folylpolyglutamate synthase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YD69_DICT6 Length = 442 Score = 454 bits (1169), Expect = e-126, Method: Composition-based stats. Identities = 119/437 (27%), Positives = 200/437 (45%), Gaps = 27/437 (6%) Query: 8 QAASPLASWLSY---LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 + + + S+++Y L+NL + LER+ + +G + F +AGT GKG+T Sbjct: 4 DSLNYVNSFINYEKRLDNLTYEEKKFYLERMRYLLQLMGNPQDNLQAFHIAGTKGKGSTS 63 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAE----IESARGDI- 119 + SIL +AGYKVG+Y+SPHL ER+ + + IE A+ Sbjct: 64 AMIFSILKSAGYKVGLYTSPHLQSIRERIATHEGFISQEEFVDLIDYAKPYIEEAKKHPI 123 Query: 120 --SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWL 177 S T+FE T A F +LD V++EVGLGGRLDATN+++ ++++T I DH L Sbjct: 124 FGSPTFFEVLTALAFLYFSMKKLDYVVIEVGLGGRLDATNVINPLISIITPIGFDHMHIL 183 Query: 178 GPDRESIGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHD 235 G E I EKAGI + K I E I V++E+ A+ + +++ + + Sbjct: 184 GDTLEKIAFEKAGIIKEGKIVISSPQKKEAEEVIERVSRERNAVYYKVDDLFSWRKKEAN 243 Query: 236 WA----FSDAHGTLENLPLPLVPQPNAATALAA-----LRASGLEVSENAIRDGIASAIL 286 + E +PL+ + A+ A + + L + ++ G + Sbjct: 244 LDGQKFLLEGRDIKEEFFIPLLGEHQIVNAVTAYGAIYVLKNRLNIDNEVVKKGFENVQW 303 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 GRFQI++++P ++ D AHN +A L +++ R+ + G++ DKD L L Sbjct: 304 RGRFQIINKNPLIVVDGAHNVDSAMALKNTLESYVNFDRLFLICGIMKDKDAEKFLKILD 363 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLV 400 +V + PL R T E+L + +D+ + A A D +L+ Sbjct: 364 PLVYSYNFIPLPSHRTRTPEELANIVKVFRPNAEINIYDNFSSAISFVNKKASPADLILI 423 Query: 401 CGSFHTVAHVMEVIDAR 417 GS + ++ R Sbjct: 424 TGSLYLAGEALDYFYGR 440 >UniRef50_A2SKX9 Cytoplasmic peptidoglycan synthetase, C-terminal domain n=4 Tax=Betaproteobacteria RepID=A2SKX9_METPP Length = 448 Score = 454 bits (1168), Expect = e-126, Method: Composition-based stats. Identities = 201/433 (46%), Positives = 262/433 (60%), Gaps = 17/433 (3%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 R P+ + LA+WL++ + LH++TID+GLERV V LG+ KP + TVAGTNGKG+TC Sbjct: 16 RRPRQGADLAAWLAHADALHAQTIDMGLERVVKVRDALGL-KPGFPLITVAGTNGKGSTC 74 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L S+L AAGY+VGVYSSPHL+RY ERVR+ G + ++A A++A +E ARG LT F Sbjct: 75 ALLASVLGAAGYRVGVYSSPHLLRYNERVRIDGAPVGDAALCAAYARVEGARGHTPLTPF 134 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E+GTL+A+ +F +A LD +LEVGLGGRLDA N DAD A+VTSI +DH ++LGP RESI Sbjct: 135 EFGTLAAMCVFAEADLDAAVLEVGLGGRLDAVNAFDADCAIVTSIGIDHVEYLGPTRESI 194 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-WAFSDAHG 243 EK+G+FR+ +PAI +PE P+TIA A+ GA L + G ++ D W S G Sbjct: 195 AVEKSGVFRAGRPAICADPEPPATIAQEARRLGARLLQSGRDYRVRRDPGDTWTLSRRSG 254 Query: 244 TLENLPLPLV----PQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSES- 296 L LPLP + NA L AL L V I G+ L GRFQ Sbjct: 255 ELGGLPLPALAGDVQLHNAGACLMALETLARTLPVDAAQIHRGLRQVQLIGRFQRWRRHP 314 Query: 297 --PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 P V+ DVAHNPHAA+ L + P GR LAV ML DKDIAGT L+ VD W+ Sbjct: 315 GAPEVLLDVAHNPHAAQRLALTLTQHPVPGRTLAVFAMLRDKDIAGTAQALRDGVDAWFV 374 Query: 355 APLEGPRGATAEQLLEHLGNGKSFDSV------AQAWDAAMADAKAEDTVLVCGSFHTVA 408 A + RGA+A + L + +V A+ A+A A +D VLVCGSF TVA Sbjct: 375 AGIAERRGASAADMAAALDAAQVQRTVHLSASPLDAYRDALASAGPDDRVLVCGSFSTVA 434 Query: 409 HVMEVIDARRSGG 421 V+ ++A + G Sbjct: 435 AVLRELEAEATAG 447 >UniRef50_Q2BMN3 Folylpolyglutamate synthase n=1 Tax=Neptuniibacter caesariensis RepID=Q2BMN3_9GAMM Length = 419 Score = 453 bits (1166), Expect = e-126, Method: Composition-based stats. Identities = 179/415 (43%), Positives = 247/415 (59%), Gaps = 11/415 (2%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WLS++E H+ IDLGL+RVS VA L + + V TVAGTNGKG+T L SI + Sbjct: 7 LTQWLSWMEQCHTAEIDLGLDRVSRVADELQLDLSSSTVVTVAGTNGKGSTVSYLSSIYL 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AGY VG Y+SPH +RY ERVR+ G E + +F I+ ARG I LTYFE+GTL+AL Sbjct: 67 QAGYSVGAYTSPHFLRYNERVRLNGLEATDEQLCDAFERIDQARGQIPLTYFEFGTLAAL 126 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +F + D+V+LEVGLGGRLDA NI+DADV+VVT++++DH DWLG DRE IG EK+GIF Sbjct: 127 IIFADTKPDLVLLEVGLGGRLDAVNIIDADVSVVTTVSIDHVDWLGDDREFIGHEKSGIF 186 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS-----DAHGTLEN 247 R++KPAI G+ P ++A A + GA L + ++++ T W + + + + Sbjct: 187 RADKPAICGDLNPPVSVAKYAADIGAELYQADQQFSFEKTKKGWHWKGLNADGSEQIIND 246 Query: 248 LPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDVAHN 306 LPLP +P NA+TA+ + L VS + I+ G+ +A L GR Q + + DVAHN Sbjct: 247 LPLPSLPLQNASTAIQVCQHIPLNVSADQIKTGLQTATLTGRMQKLEVDGVNYWLDVAHN 306 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 P AAE L R+K +P V ++GML DKD + + VVD Y L PRG A Sbjct: 307 PEAAELLAKRIKDMP--KPVTLLLGMLADKDCQQVIDLITPVVDSIYLTDLNVPRGQKAS 364 Query: 367 QLLEHLGNGK---SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 L L +G D+V A + AE+ V++ GSF TV+ + + + Sbjct: 365 ALAALLPSGVHALQADTVKSAIEQIKKHTNAEENVIIAGSFFTVSDALSELGKEK 419 >UniRef50_Q1JY09 FolC bifunctional protein n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1JY09_DESAC Length = 430 Score = 451 bits (1162), Expect = e-125, Method: Composition-based stats. Identities = 134/422 (31%), Positives = 199/422 (47%), Gaps = 21/422 (4%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 TP AA L +L L I LGLE + + +G + + VAGTNGKG+ C Sbjct: 2 NTPDAA------LEFLYGLQMFGIKLGLENIQTLVDSVGQPQRNYGIVHVAGTNGKGSVC 55 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L I AGY+VGVY+SPHL R+ ER+RV GQ + + A E+ ++ T+F Sbjct: 56 AFLGRIYRQAGYQVGVYTSPHLHRFNERIRVNGQPIDDHDLVALVDELRQKNSEVPATFF 115 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E+ T AL F + +D+VILEVG+GGRLDATN+V V+V+T ++ DH D+LG I Sbjct: 116 EFTTALALLYFARQNVDLVILEVGMGGRLDATNVVAPLVSVITPVSDDHGDYLGGSLAEI 175 Query: 185 GREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 EK GI + P ++G + + ++ A+E A G +++ T + Sbjct: 176 AAEKGGIIKPGVPVVIGPQDKAAMAVLSARAKEMAAPCLCFGRDFSVEKTTSGCRVTTGA 235 Query: 243 GTLENLPLPLVPQPN---AATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSES 296 L L + A AL L G +V++ +R+ +A PGR + V E Sbjct: 236 LCWSELQPSLPGRHQYDNLAVALMVVTHLAEQGWQVTQQVVREAVADTRWPGRLEWVGE- 294 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 R++ D AHN A L ++ R+ V G DKD+ ++ L V YC Sbjct: 295 -RILLDGAHNASGAHALADYLRGCNV-QRIHWVAGFKADKDMEAVVSSLLPFVVQAYCVE 352 Query: 357 LEGPRGATAEQ----LLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 + E L +H ++DS A +AA+ D V+V GS VA + Sbjct: 353 PPTEQAYPRENVVVHLQQHGCEASAWDSPTVALEAALQQCGDHDLVVVAGSLFLVAACRD 412 Query: 413 VI 414 + Sbjct: 413 WL 414 >UniRef50_A6GNX1 FolC bifunctional protein n=1 Tax=Limnobacter sp. MED105 RepID=A6GNX1_9BURK Length = 468 Score = 451 bits (1162), Expect = e-125, Method: Composition-based stats. Identities = 191/463 (41%), Positives = 250/463 (53%), Gaps = 63/463 (13%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P A + L WL+YLE++HSK ID+GL+R+ +V + VFTVAGTNGKG+TC Sbjct: 16 PNADASLNDWLAYLESIHSKPIDMGLDRLKVVQQHMNFTLKGV-VFTVAGTNGKGSTCAM 74 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR--GDISLTYF 124 LESIL+ AGYKVG+Y+SPHL+R+TER R+ G+E+ ES ++F ++E R ISLTYF Sbjct: 75 LESILIQAGYKVGMYTSPHLIRFTERARINGEEVSESELISAFEKVEQTRVATGISLTYF 134 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E+ TL+ +F + L+ VILEVGLGGRLDA NI DAD A+ TS+ +DH +LGPDRESI Sbjct: 135 EFTTLAVALVFSRLDLEAVILEVGLGGRLDAVNIFDADCAICTSVDIDHQAFLGPDRESI 194 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 GREKAGIFR KPAIVG+P+ P ++ D A GA L ++NYS WA+ Sbjct: 195 GREKAGIFRPGKPAIVGDPKPPQSVIDHANSIGADLWLFSRDYNYSGDKQQWAYGGRSMR 254 Query: 245 LENLPLPLVPQPNAATALAALR------------------ASGLEVSENAIRDGIASAIL 286 AA A ALR L V +IR G Sbjct: 255 ------------RAALAYPALRGTNQLLNASAALAALESVRDRLPVPAQSIRQGFLLVEW 302 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 PGRFQ++ P V+ DV HNPHAA +L + + + GML DKD + LK Sbjct: 303 PGRFQVLPGQPTVVLDVGHNPHAAAHLRESLDNMGFFPYTHCIFGMLADKDAVEVVKALK 362 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHL------------------------------GNGK 376 VD W+ PLEG RG + EQL + L + + Sbjct: 363 DRVDHWHLVPLEGDRGRSTEQLKQQLELAGVDAGAFDWVANSQALAKGGIAKQPPEKSVQ 422 Query: 377 SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 S++SV QA+ + D +LV GSF VA M+ +A R Sbjct: 423 SYESVGQAYAVVTSAVPPNDRILVFGSFLVVAQAMQAKEALRK 465 >UniRef50_Q05865 Folylpolyglutamate synthase n=5 Tax=Bacillus subtilis group RepID=FOLC_BACSU Length = 430 Score = 451 bits (1161), Expect = e-125, Method: Composition-based stats. Identities = 121/428 (28%), Positives = 193/428 (45%), Gaps = 23/428 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + S++ + GL R+ + ARLG + F VAGTNGKG+T + S+ Sbjct: 3 TAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAFHVAGTNGKGSTVAFIRSM 62 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYF 124 L AGY VG ++SP+++ + ER+ V G + + TA +++ + T F Sbjct: 63 LQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVNQMKPHVEALDQTEYGQPTEF 122 Query: 125 EYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 E T A F + ++D VI E GLGGR D+TN+V+ + V+TSI DH + LG E Sbjct: 123 EIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEPLLTVITSIGHDHMNILGNTIEE 182 Query: 184 IGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGAL---LQRRGVEWNYSV--TDHDW 236 I EKAGI + P + +PE I A+ A L V +N + Sbjct: 183 IAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHAAPFQSLHDACVIFNEEALPAGEQF 242 Query: 237 AFSDAHGTLENLPLPLV---PQPNAATALAALRASGLE----VSENAIRDGIASAILPGR 289 +F E++ L+ + NAA ++ A E +S+ A+R G+ A PGR Sbjct: 243 SFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEWLNKENIAHISDEALRSGLVKAAWPGR 302 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 ++V E P V D AHN E L MK N R+ V L DK + L+++ Sbjct: 303 LELVQEHPPVYLDGAHNEEGVEKLAETMKQRFANSRISVVFSALKDKPYQNMIKRLETIA 362 Query: 350 DDWYCAPLEGPRGATAEQL--LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 + A + PR + A+ L + N + + + + VL+ GS + + Sbjct: 363 HAIHFASFDFPRASLAKDLYDASEISNKSWSEDPDDVIKFIESKKGSNEIVLITGSLYFI 422 Query: 408 AHVMEVID 415 + + + + Sbjct: 423 SDIRKRLK 430 >UniRef50_A8SN77 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SN77_9FIRM Length = 425 Score = 449 bits (1157), Expect = e-125, Method: Composition-based stats. Identities = 114/405 (28%), Positives = 192/405 (47%), Gaps = 16/405 (3%) Query: 26 KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPH 85 + LGL+ + + +LG + + +AGTNGKG+ + S+L++ GYKVG+++SP Sbjct: 16 SGVKLGLQNIKNLMEKLGNPQDKLKIIHIAGTNGKGSCTSFVNSVLVSQGYKVGMFTSPS 75 Query: 86 LVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSALWLFKQAQLDVV 143 + + ER+R+ + +PE E+ ++ FE T A F + D Sbjct: 76 IYNFEERIRINNKNIPEDKLIELMNEVREIANTLEVFPADFELVTALAFLYFYRENCDFA 135 Query: 144 ILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV-- 200 I+EVGLGGRLDATN++ + ++TSI+ DH +LG + I EKAGI + P ++ Sbjct: 136 IMEVGLGGRLDATNVINKPLITLITSISFDHQQFLGNTIKEIALEKAGIIKDGVPLVLYS 195 Query: 201 GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAAT 260 + E+ I VA+ K + + + + + + +NL + L+ Sbjct: 196 QDTEIMDNIMGVAKSKNSKVIVNDLSKIKVLENKKSGQVIDYKDFKNLKINLLGSHQVKN 255 Query: 261 A------LAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLT 314 A L LR G E+S +I +G ++ P RF++VS+SP I D AHN E Sbjct: 256 ATISLELLLELRKIGFEISNESIYNGFSTVTWPCRFELVSKSPDFILDGAHNIDGIEKFV 315 Query: 315 GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL-- 372 M KN + +A+ G+L DKD L + D + + R A +L E + Sbjct: 316 SNMNFYYKNNKKIAIFGVLADKDYNEMLEKIVPCFDVFLTVRPDSERAMEAYELKEKIEA 375 Query: 373 ---GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 SF++ +A D A + +D + GS + V + +++ Sbjct: 376 LTEKKVYSFENYQEAIDKAFEISSKDDVISAFGSLYFVGEIRKLL 420 >UniRef50_B9XQF6 FolC bifunctional protein n=1 Tax=bacterium Ellin514 RepID=B9XQF6_9BACT Length = 435 Score = 449 bits (1156), Expect = e-124, Method: Composition-based stats. Identities = 137/421 (32%), Positives = 197/421 (46%), Gaps = 27/421 (6%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 + +L NL LGLE +A G + VAGTNGKG+TC LESI A Sbjct: 5 EAIQFLYNLQVFGTKLGLENTYRLAKLAGNPQEKLRFIHVAGTNGKGSTCAMLESIYRHA 64 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR----GDISLTYFEYGTLS 130 G KVG+++SPHLV + ER+++ + + E E+++ D T+FE T+ Sbjct: 65 GLKVGLFTSPHLVAFGERIQINRELISEEEIIRLVEEMKALLQEFPADEHPTFFEVVTIM 124 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 AL F + + DVVI E GLGGRLDATNIV V+V+T+I DH WLG I EKAG Sbjct: 125 ALSYFARQKCDVVIWETGLGGRLDATNIVTPLVSVITNIQFDHQKWLGDTLAKIAFEKAG 184 Query: 191 IFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 I + P I +PE + AQEK A WA ++ H ++ L Sbjct: 185 IIKPRVPVITAVDDPEALRILFKTAQEKAAPFSLI-----------TWAQTEFHP-MQGL 232 Query: 249 PLPLVPQPN---AATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSE--SPRVIF 301 LPL+ + AATA+ A+ A+ + VS+ IR G++ PGR Q+V +V+ Sbjct: 233 TLPLLGEHQRLNAATAVHAVMAARSCIPVSDETIRKGLSGVKWPGRLQLVERKNGQKVLL 292 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D AHN +AE L + R V+G+L DKD + + P+ R Sbjct: 293 DGAHNIGSAEALKTALNTYFATRRPTLVMGILSDKDAHPMCEIIAPLAGRILLVPVNSQR 352 Query: 362 GATAEQLLEHLGNGKSFDSVAQA--WDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 +L+ V + A+ A + V V GS + + ME++ + Sbjct: 353 TILPRELIPVCRRANPDVEVRECRSLKEALDVAAEDPFVAVTGSLYLIGEAMELLGLSPA 412 Query: 420 G 420 G Sbjct: 413 G 413 >UniRef50_A1SW71 FolC bifunctional protein n=2 Tax=Psychromonas RepID=A1SW71_PSYIN Length = 428 Score = 449 bits (1156), Expect = e-124, Method: Composition-based stats. Identities = 187/426 (43%), Positives = 265/426 (62%), Gaps = 17/426 (3%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 +I ++ PQ L WL+Y+E LH IDLGL R++ VA+ L V+ V TVAGTNGK Sbjct: 4 VIPQKLPQ---TLPQWLAYIEILHPSAIDLGLSRIAKVASALQVINFDAQVITVAGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 GTTC LE IL+ AG+KVGVYSSPH+ RYTER+R+ QEL + AH +F+ IE R + S Sbjct: 61 GTTCAFLEEILLQAGFKVGVYSSPHIQRYTERLRINKQELSDQAHCDAFSAIEKIRKETS 120 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 L+YFEY TL L L KQA D ++LEVGLGGRLDATN+V++D +V+T+I +DH DWLG D Sbjct: 121 LSYFEYATLGCLSLLKQAHCDYILLEVGLGGRLDATNVVESDASVITTIDIDHIDWLGSD 180 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD 240 RE IG EKAG+FR+ KP I GE + P ++ AQ ++ G +++Y VT W +S Sbjct: 181 REKIGFEKAGVFRANKPVICGEFDPPLSLQAHAQNLNCQIKYAGKDFSYQVTGKQWNWSG 240 Query: 241 AHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES--PR 298 TL+++ LPL+P NA+TALA + A ++V+ +++ I +A L GR Q +S + Sbjct: 241 KQ-TLKDIRLPLLPVQNASTALAVIEALQVKVNPAVLKNAIENASLAGRLQKISTTSVCD 299 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNG----RVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 V DVAHNP +A YL +++ + +V A++GML DKDI GT + + +D Sbjct: 300 VYLDVAHNPQSAGYLASQLRLIKAEKPEKCKVHAIVGMLADKDITGTFDQINTEIDFCNL 359 Query: 355 APLEGPRGATAEQLLE-------HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 L+ RG +A+ LLE L F++V A++ + D +++ GSFHTV Sbjct: 360 VSLDCYRGLSADSLLENHQKSKNALTTPICFENVNLAYETVRNKVDSSDIIIIFGSFHTV 419 Query: 408 AHVMEV 413 + + Sbjct: 420 SDFLNF 425 >UniRef50_Q3IF42 Bifunctional: folylpolyglutamate synthase; dihydrofolate synthase n=3 Tax=Alteromonadales RepID=Q3IF42_PSEHT Length = 421 Score = 449 bits (1155), Expect = e-124, Method: Composition-based stats. Identities = 180/422 (42%), Positives = 254/422 (60%), Gaps = 8/422 (1%) Query: 2 IIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 + K P +S L WL YLE++H + I +GLERV+ VA +G+L + + +AGTNGKG Sbjct: 1 MTKTIPSQSSSLDDWLFYLESVHPENIAMGLERVASVANNIGLLNTSSKIILIAGTNGKG 60 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL 121 TT R LES+L+A G VG Y+SPHL Y ERVRV GQEL + H +F +E R D +L Sbjct: 61 TTARCLESLLLAQGLSVGTYASPHLTHYNERVRVNGQELSDQYHVDAFHLLEQGRKDTAL 120 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 TYFEYGTL+AL +FK+ ++D V+LEVGLGGR DATNIV +V+T+I LDH ++LG R Sbjct: 121 TYFEYGTLAALAIFKRCEVDYVLLEVGLGGRYDATNIVTPFASVITTIDLDHKEYLGDTR 180 Query: 182 ESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 E + +KAGIFR PAI+G+ +P T+ D E A + G ++ + +++ Sbjct: 181 ELVAYDKAGIFRENTPAIIGDLNIPHTMTDYGDEINAKMVLSGSDFIFKEHADTFSWQYQ 240 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 LE L P +P NAATAL L L SE+ I+ +A+ ++ GRF+ +S+ P V Sbjct: 241 QYNLE-LAKPAIPSQNAATALTTLSVLNLLPSESVIKACLANLVVEGRFEQLSDQPLVYT 299 Query: 302 DVAHNPHAAEYLTGRMKAL-PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHNP +A YL ++ + K ++ A++ ML DKD AG L + +VD W A L GP Sbjct: 300 DVAHNPESARYLASKLLSYKDKGFKIHALVAMLADKDKAGVLKEVSHLVDQWSLASLNGP 359 Query: 361 RGATAEQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 RG +A L L + S++SVA A D + + + ++V GSF TVA ++ Sbjct: 360 RGDSASNLQNALQSIPHNDIKHSYNSVAAALDVILPTQQNDTVLIVFGSFFTVAGAIDYF 419 Query: 415 DA 416 Sbjct: 420 KK 421 >UniRef50_D2RP25 FolC bifunctional protein n=2 Tax=Acidaminococcus RepID=D2RP25_ACIFE Length = 426 Score = 448 bits (1153), Expect = e-124, Method: Composition-based stats. Identities = 132/424 (31%), Positives = 202/424 (47%), Gaps = 19/424 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 ++ ++Y+E+L I LG+ER+ + A L + V GTNGKG+ L ++L Sbjct: 3 YSAAVTYVESLGKFGIHLGMERIQGLTALLDHPERKIRTIHVTGTNGKGSVTTFLANMLQ 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEY 126 AG KVG Y+SPH VRY ER+ + G+E+ A ++A G T FE+ Sbjct: 63 QAGKKVGSYTSPHFVRYNERICLNGEEISNEDFAAVTERTKAALDRFLAEGGEQPTQFEF 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T A F + Q+D ++EVG+GG D+TNI+ +V+V+T++ L+HTD LG E+I Sbjct: 123 ITAMAFLYFAEKQVDYAVIEVGMGGLWDSTNIITPEVSVITNVTLEHTDRLGKTIEAIAA 182 Query: 187 EKAGIFRSEKPAIV-GEPEMPSTIADVAQEKGALLQRRGVEWN-----YSVTDHDWAFSD 240 +KAGI + P + E + I A+ A L G +++ S+ + + Sbjct: 183 QKAGIIKPGVPVVTEAEGKALEVIRGTAEASHAPLYVYGDDFSTEELTSSMDAQTFLYRM 242 Query: 241 AHGTLE-NLPLPLVPQ----PNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSE 295 +E + LP Q A A LR + E A+ G+ +A PGR + + Sbjct: 243 GEKEMEVTIHLPGEHQILNGAAALAAAEILREKDGSIDEAAMLRGMDAARWPGRLERIHR 302 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 +P +I D AHNP L + R + V GM+ DKD++ L D Y Sbjct: 303 NPDIILDGAHNPSGVTVLRKALDEYYPGARRIYVFGMMADKDVSQVSEILFRPEDTIYTV 362 Query: 356 -PLEGPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 EG R E+L L N D +A A+ A+ +A ED V+VCGS + + E+ Sbjct: 363 LAHEGDRSEKPEKLARRLHKNAVPMDELAAAYRRAVQEAGPEDVVIVCGSLYLIGTFKEL 422 Query: 414 IDAR 417 R Sbjct: 423 GLDR 426 >UniRef50_D0WG21 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Slackia exigua ATCC 700122 RepID=D0WG21_9ACTN Length = 442 Score = 447 bits (1151), Expect = e-124, Method: Composition-based stats. Identities = 135/417 (32%), Positives = 203/417 (48%), Gaps = 17/417 (4%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 +YL+ + +DLGL+R + A LG + A + VAGTNGKG+T + IL AAGY Sbjct: 24 AYLQQGSWRDMDLGLDRTRALLAALGNPQDAYPIVHVAGTNGKGSTSAFIAGILQAAGYD 83 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSALWLF 135 G+++SP ++R+ ER++V ++ + + A D+ T FE T AL F Sbjct: 84 TGLFTSPFILRFNERIQVNRVDISDGELDEVARAVRDAAASIDVHPTAFELITAVALEHF 143 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 ++ D V+LEVGLGGRLDATN+V +TSIA DH LG I EKAGI + Sbjct: 144 RRRGCDAVVLEVGLGGRLDATNVVVPAACAITSIAFDHMRILGDTLAQIAAEKAGIVKPG 203 Query: 196 KPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV 253 P + PE + I D + G++L V ++ ++ + ++ L L+ Sbjct: 204 VPVVSYRQAPEAQAVIEDACRAAGSVL-VFPRFGRIHVRQEGFSQVFSYDGIADVRLSLL 262 Query: 254 PQPNAATALAA------LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNP 307 A+ A LR GL +S++AI+ G+ + PGRF++V+ SP I D HN Sbjct: 263 GTYQPCNAVMAIEVARVLRTRGLAISDDAIKRGLETTRWPGRFELVAASPTTIVDGGHNE 322 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP-RGATAE 366 A L ++A + V V GML DK +A + + YC P R A Sbjct: 323 QGAAMLASSLRAYFPHRTVTFVAGMLKDKRYRDMVALVAPLAAKVYCVEPPEPERALPAA 382 Query: 367 QLLEHLGNGKSFDSVAQA-----WDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 L + D+VA A A A+A +D V GS ++++ VME + + R Sbjct: 383 DLAQEFVRAGVADTVACASIADGVHRARAEASPDDVVCCFGSLYSISEVMEALGSSR 439 >UniRef50_A1UZ44 FolC bifunctional protein n=107 Tax=cellular organisms RepID=A1UZ44_BURMS Length = 461 Score = 447 bits (1150), Expect = e-124, Method: Composition-based stats. Identities = 179/435 (41%), Positives = 238/435 (54%), Gaps = 25/435 (5%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 L +WLS+LE+ H ID+GL R+ V L + A V TV GTNGKG+TC + Sbjct: 26 STFPTLDAWLSHLESAHPVGIDMGLARIGQVKDALKLAF-ACPVITVGGTNGKGSTCAFI 84 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR----GDISLTY 123 E+IL+ AGYKVG ++SPHL+R+ ER R+ G+ + + F +E+AR +SLTY Sbjct: 85 ETILVRAGYKVGCHTSPHLLRFNERARLDGRIVDDEELLPHFEAVEAARTSLPEAVSLTY 144 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE+ TL+ + LF LD VILEVGLGGRLDA N++DAD A+VTSI +DH ++LG RE Sbjct: 145 FEFTTLAIMHLFASRGLDAVILEVGLGGRLDAVNVIDADCAIVTSIDVDHIEYLGDTREK 204 Query: 184 IGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV----TDHDWAFS 239 I EKAGIFR KPAI G+P P T+ D A GA L G ++ +S W ++ Sbjct: 205 IAFEKAGIFRPGKPAICGDPAPPQTLVDHAGAIGADLWLVGRDFRFSTQPGSERQQWTYA 264 Query: 240 DAHGTLENLPLPLV------PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIV 293 L P + +AA A L VS IR G+A+ LPGRFQ++ Sbjct: 265 GRDKRYPALAYPALRGANQLLNASAALAALEALRERLPVSAQDIRLGLANVELPGRFQVL 324 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 P V+ DVAHNPHAA L + ++ AV G + DKD+AG + LK +D W+ Sbjct: 325 PGKPLVLLDVAHNPHAAAVLAQNLDSMGYYPYTHAVFGAMADKDLAGIVERLKGAIDHWH 384 Query: 354 CAPLEGPRGATAEQLLEHLG----------NGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 L PR A A+ L L N A A+ A+ A D ++V GS Sbjct: 385 LTDLPLPRAAAADVLERVLRGAGVEHGAQHNITRHAGPADAFLDALKSASDNDRIVVFGS 444 Query: 404 FHTVAHVMEVIDARR 418 F+TVA VM V+D R Sbjct: 445 FYTVAGVMPVVDRRH 459 >UniRef50_B8FVG3 FolC bifunctional protein n=2 Tax=Desulfitobacterium hafniense RepID=B8FVG3_DESHD Length = 459 Score = 446 bits (1148), Expect = e-124, Method: Composition-based stats. Identities = 126/428 (29%), Positives = 205/428 (47%), Gaps = 26/428 (6%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 YL +L ++ GL R+ + R+G + V + GTNGKG+T IL AGY+ Sbjct: 33 DYLVSLTKFGMNFGLGRIEELLKRMGNPEERLRVVHIGGTNGKGSTTMMTAEILEDAGYR 92 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYGTLSA 131 VGV++SPHL Y ER+ + G+ +P+ T + ++ T FE T A Sbjct: 93 VGVFTSPHLHDYRERITINGEMIPKGEVTRLIQILRPHLEELVQKGVEHPTEFEVNTAMA 152 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 L F ++D+V+LEVGLGG +D+TN+V ++V+T++ +DH D+LG E I KAGI Sbjct: 153 LMYFADQKVDLVLLEVGLGGAIDSTNVVKPLISVITNVGMDHMDYLGETYEEIAGVKAGI 212 Query: 192 FRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT-----DHDWAFSDAHGT 244 ++ + PE+ + I AQE + L G + + + + ++ + G Sbjct: 213 IKAGAITVTAADRPEVLNVIRKKAQEMNSPLWVVGDDVRWEIRWSGELEQEFDLAGLRGA 272 Query: 245 LENLPLPLVPQPN---AATALAALRASGLE----VSENAIRDGIASAILPGRFQIVSESP 297 L L LV + AATA+ E + I +G+ A+ PGR +++S P Sbjct: 273 YNKLRLRLVGEHQVVNAATAVTVCELLKFEYGMNLERRNIYEGLRKAVWPGRLELLSLKP 332 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 +V+ D AHN A L + + + R++ +GML DK+ + L + D+ Sbjct: 333 KVLIDGAHNVDGAHALAKALN-IFQRQRLVLCLGMLGDKEREKVVDILVPLADEVIITKP 391 Query: 358 EGPRGATAEQLLEHLGN-GKSFDSVAQ---AWDAAMADAKAEDTVLVCGSFHTVAHVME- 412 PR E L E + GK ++ + A + A ED + V GS + +A + Sbjct: 392 NSPRSGNWEYLHELVKEKGKPVLTIEEPRLAVEEAFRRLDKEDMLCVTGSLYMIAEARQA 451 Query: 413 VIDARRSG 420 ++D R G Sbjct: 452 LLDVLRKG 459 >UniRef50_B9MJT0 FolC bifunctional protein n=2 Tax=Clostridiales RepID=B9MJT0_ANATD Length = 432 Score = 446 bits (1148), Expect = e-124, Method: Composition-based stats. Identities = 113/426 (26%), Positives = 198/426 (46%), Gaps = 21/426 (4%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L ++ + + LGLE ++ + +G + V VAGTNGKG+TC + +L Sbjct: 2 TYEQALDFIHSTYKFGTKLGLENITKLLEFMGNPQKGLKVIHVAGTNGKGSTCAFINQML 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFE 125 + AG++VG+Y+SP L + ER+++ Q + + ++ ++ T FE Sbjct: 62 IEAGFRVGLYTSPFLESFNERIKLNNQPIDNQELASITEFVKERIEELIRQGFSHPTEFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESI 184 T FK+ +D V+LEVGLGGR DATN+V+ ++ V+TSI DH D LG E I Sbjct: 122 VVTAIGFEFFKRKNVDFVVLEVGLGGRFDATNVVENPEICVITSIGFDHMDILGSTIEKI 181 Query: 185 GREKAGIFRSEKPAIVGEP---EMPSTIADVAQEKGALLQRRGVEWNY---SVTDHDWAF 238 EKAGI + I+ E+ I+ V +E+ A L ++ ++ + Sbjct: 182 AFEKAGIIKQNTKVILALQRYEEVKEVISKVCKEQNAQLIEVERNYHVLKSTLEGIVFDC 241 Query: 239 SDAHGTLENLPLPLVPQPNAATALAAL-----RASGLEVSENAIRDGIASAILPGRFQIV 293 G +NL + L+ AL + ++ A+ G+ +A GRF+++ Sbjct: 242 VTPKGIYKNLEIKLLGTHQVENALNCVYVYECLKEKYDIKTEALIKGLLNARWNGRFEVL 301 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 ++P V+ D AHN + L K + +++AV+G+L DK+ ++ +KSV Sbjct: 302 IDTPLVVLDGAHNVDGMKVLVENCKIYLNDKKIVAVVGILKDKEYEKMISLIKSVAQRVI 361 Query: 354 CAPLEGP-RGATAEQLLEHLGNG--KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 + R + ++ LE + +A A+ +D V++CGS + V Sbjct: 362 FTLVPSQKRAFSEKEALEISHKCGVEFVPDFREAIKYALGLCNEDDAVIICGSLYLVGAA 421 Query: 411 MEVIDA 416 + + Sbjct: 422 RGFLKS 427 >UniRef50_B5JSE1 FolC bifunctional protein n=1 Tax=gamma proteobacterium HTCC5015 RepID=B5JSE1_9GAMM Length = 427 Score = 445 bits (1146), Expect = e-123, Method: Composition-based stats. Identities = 180/416 (43%), Positives = 251/416 (60%), Gaps = 17/416 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L +WLS+ LHS +DLGL+R+ V ARL + V TVAGTNGKG+T LESI Sbjct: 6 DSLQAWLSWQGRLHSSEVDLGLDRIRAVLARLSLDFSQSIVVTVAGTNGKGSTLAFLESI 65 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 AGY+VG+++SPH + Y ER+R+ G + E A +FA I+S RG+ISLTYFE+ TL+ Sbjct: 66 YRQAGYRVGLFTSPHFLHYCERIRIDGDRVSEQAVCDAFAAIDSVRGEISLTYFEFSTLA 125 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 ALWLF + L V++LEVGLGGRLDA+N++DADV +VTS+++DH DWLG +RE IGREKAG Sbjct: 126 ALWLFARESLAVILLEVGLGGRLDASNVIDADVGIVTSVSIDHRDWLGDNREDIGREKAG 185 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 I+R + AI G+P P ++ +VA KG+ Q RG ++ + D A E+ Sbjct: 186 IYRRNRMAISGDPHPPHSLREVASIKGSDWQGRGEQFEVFTSSEDRARWRLQWRGEDFEF 245 Query: 251 PL-------VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 P + NAA+AL A LRA V ++ + G+ A LPGR Q++ ++P V+ Sbjct: 246 PYPERLTAPIQLDNAASALVAVLGLRAQR-PVDKSDMDRGLCQAGLPGRLQVIGQNPEVM 304 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHN AA+ L G + +V V+GML DK++ T + L+++ WY A + Sbjct: 305 LDVAHNEAAAKALFGAVAGR-SYEQVHLVLGMLQDKEVRATASVLEALQPHWYLATPQSE 363 Query: 361 RGATAEQLLEHLGNGKS-----FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 R +L L + + SV +A+ AA+ A D V+V GSF TVA VM Sbjct: 364 RAMDCRELAAMLPGSAASASVCYASVTEAYRAALGRAGENDLVIVTGSFFTVAEVM 419 >UniRef50_Q6FEE4 Bifunctional protein n=18 Tax=Acinetobacter RepID=Q6FEE4_ACIAD Length = 428 Score = 445 bits (1146), Expect = e-123, Method: Composition-based stats. Identities = 180/428 (42%), Positives = 255/428 (59%), Gaps = 11/428 (2%) Query: 2 IIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 + P L +WL+Y ++H IDLGLERV VA +LGV + + VFTVAGTNGKG Sbjct: 1 MKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD--I 119 +T TL SIL GY+VG+Y SPH+ R+ ERV++ GQE + +F +++ R + + Sbjct: 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120 Query: 120 SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGP 179 SL++FE TL+A +F+Q D+ +LEVGLGGRLD N++D DVAV+T+I LDHTDWLG Sbjct: 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180 Query: 180 DRESIGREKAGIFRSEKPAIVGEPE-MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF 238 E I EKAGI RS P I G + +P IAD A + A L G ++ Y V ++ Sbjct: 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240 Query: 239 SDA-HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRF-QIVSES 296 + A GT LPL + N +TA+AAL SG++VS+ AI GI A L GRF Q + ++ Sbjct: 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGR----VLAVIGMLHDKDIAGTLAWLKSVVDDW 352 V+FD HN H ++L +++ + + V+AV ML DKDI + LK V W Sbjct: 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360 Query: 353 YCAPLEGPRGATAEQLLEHLGN--GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 A L PR A QLL+ L + +DS+ +A+ A+ +++ +LVCGSFHT+ V Sbjct: 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420 Query: 411 MEVIDARR 418 E ++ + Sbjct: 421 WEYLEKCQ 428 >UniRef50_C0QB10 FolC n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QB10_DESAH Length = 480 Score = 445 bits (1146), Expect = e-123, Method: Composition-based stats. Identities = 125/437 (28%), Positives = 207/437 (47%), Gaps = 27/437 (6%) Query: 4 KRTPQAASPL-----ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTN 58 KRT +A+ + L + I LGLE +S + LG + +AGTN Sbjct: 39 KRTDRASHKMKQISYEECLERMYKRGRFGIKLGLETISEILTNLGSPEKRFKSIHIAGTN 98 Query: 59 GKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR-G 117 GKG+ + SIL AG+KVG+Y+SPHL+++ ER + G+E+ ++ ++ + A Sbjct: 99 GKGSIASYIASILKEAGFKVGLYTSPHLIKFNERFVINGREVSDNDIVEAYVALNKADTA 158 Query: 118 DISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWL 177 + T+FE T A +LF + ++ I+E G+GGRLDATNI+ ++V+++I+L+HT++L Sbjct: 159 ERKATFFELATAIAFYLFAREGVEWAIIETGMGGRLDATNILLPKLSVISNISLEHTEYL 218 Query: 178 GPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD 235 G E+I EK GI + + P + G + + + +AQ+ A L R +++ S Sbjct: 219 GNTLEAIAMEKGGIIKHKTPVVTGVNQENALAVLTKLAQKNMAPLYRLDNDFHVSQEPDR 278 Query: 236 WAF------SDAHGTLENLPLPLVPQPNAATALAALRASGLE-------VSENAIRDGIA 282 F G LP L N+A A+AA+ +S+ I+ GI+ Sbjct: 279 TRFTYNGIERTITGVQTRLP-GLHQLDNSAIAIAAVELVFPPQKKQASVLSDEIIQRGIS 337 Query: 283 SAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTL 342 PGR + + ++P V+ D AHN AA L + + R+ V+G+L DKD + L Sbjct: 338 KTQWPGRLETIMQTPFVVIDGAHNLAAAINLARYFEEKFSDKRLTLVLGILDDKDFSSML 397 Query: 343 AWLKSVVDDWYCAPLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDT 397 D + R L + G + V A A+A + ++D Sbjct: 398 KQFVPWADRIIFTRADNKRSIDPHLLEQTARTLFTGEITVIEKVGDAVAHAIATSSSQDA 457 Query: 398 VLVCGSFHTVAHVMEVI 414 V + GS + + I Sbjct: 458 VCIAGSLYVAGEARKKI 474 >UniRef50_A7C245 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Beggiatoa sp. PS RepID=A7C245_9GAMM Length = 441 Score = 444 bits (1143), Expect = e-123, Method: Composition-based stats. Identities = 175/431 (40%), Positives = 247/431 (57%), Gaps = 28/431 (6%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + L WL++ +LH I+LGL+RV+ VA RL +L P + TVAGTNGKG++ L+SI Sbjct: 4 TTLKQWLNWQSSLHPTEIELGLDRVTTVAKRLNLLPPPFPIITVAGTNGKGSSIILLDSI 63 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L AGY VG + SPHL+RY ER+ V G E + +F IE RG+ISLTYFE+ TL+ Sbjct: 64 LSTAGYHVGRFMSPHLLRYNERICVGGVEASDVQICHTFELIEKVRGEISLTYFEFSTLA 123 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ +F+ Q+D+ +LEVGLGGRLDA NI DAD+ +VT+I +DHTDWLG DRESIG EKAG Sbjct: 124 AMLIFQHNQVDIAVLEVGLGGRLDAVNIFDADITLVTAIDIDHTDWLGNDRESIGFEKAG 183 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV---TDHDWAFSD------- 240 IFR+ PA+ + P ++ + A+ L +++Y + W Sbjct: 184 IFRAHCPAVCSDTNPPQSLINYAEHLKTPLYYLNHDFSYFKKADKNPSWQMKCHLKSLPL 243 Query: 241 -------AHGTLENLPLPLV----PQPNAATALA--ALRASGLEVSENAIRDGIASAILP 287 +LPLP + NAA L AL + V + AI G+ ILP Sbjct: 244 SPINKKKYQYIFSHLPLPNLVGDFQLQNAAGVLMVLALLSDRFPVLDAAIHQGLTHLILP 303 Query: 288 GRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS 347 GRFQI+ I DV HNP A+ L ++ P G AV+GML+DKDI L +++ Sbjct: 304 GRFQILKGRVTRILDVTHNPLGAKVLAKLLEQHPCEGETHAVVGMLNDKDITSVLTIMQN 363 Query: 348 VVDDWYCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADAKAEDTVLVCG 402 +D W+ APL+ R A + L+++L S+ S+ +A++ +A A D ++V G Sbjct: 364 SIDHWHVAPLDTARSADIDVLIDNLTTLGITLIYSYSSIQEAYEEWLAYAPDGDRIVVFG 423 Query: 403 SFHTVAHVMEV 413 SF+ VA +EV Sbjct: 424 SFYAVAEALEV 434 >UniRef50_C0GEY6 FolC bifunctional protein n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GEY6_9FIRM Length = 431 Score = 443 bits (1141), Expect = e-123, Method: Composition-based stats. Identities = 125/426 (29%), Positives = 206/426 (48%), Gaps = 22/426 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + ++ +L+ I+ GLER++ + RL + +AGTNGKG+T L S+L Sbjct: 3 YNEAIDWIHSLYRFGINPGLERITELLRRLEDPQKKIRCIHIAGTNGKGSTAAFLASMLE 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LTYFEY 126 A G +VG+Y+SP+L +T R+ + G ++ E+ +I +IS T FE Sbjct: 63 AQGLQVGLYTSPYLEAFTNRMAINGGDIDENRLAELVTQIRRHVEEISQTEAGQPTEFEV 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T A F + Q D VI+EVGLGGRLDATN+++ V+V+T+I L+HT LG +I Sbjct: 123 VTALAFLYFAEEQPDWVIMEVGLGGRLDATNVIEPAVSVLTNIGLEHTQVLGDTISAIAF 182 Query: 187 EKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY-----SVTDHDWAFS 239 EKAGI + PA+ + + VA E+GA L ++ Y S+ + + Sbjct: 183 EKAGIIKPSTPAVTAAEKEDALQVFRSVAVERGATLVEMDRDFGYEQLSASLDGQVFNYW 242 Query: 240 DAHGTLENLPLPLVPQPN---AATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 L+NL + L+ AA A+A + + +AI G+A+A PGR ++ S Sbjct: 243 SRQRKLDNLQISLLGPHQVRNAALAVATRELLPVPLDTDAIYRGLAAAKWPGRLEVFSRR 302 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD-WYCA 355 P V+ D AHN + L + + + V+G+L DK + L+ + + Sbjct: 303 PLVLVDGAHNIDGIKALKSALDTILDGRPLRLVLGILGDKAVDEILSLIVPLATAGLIVT 362 Query: 356 PLEGPRGATAEQLLEHLGNGKSF-----DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 + PR + ++ E S D+V +A +A E+ + + GS +T++ Sbjct: 363 KPDNPRASNPREVAELARRYTSAPVAATDTVEEAVALGLAQTGEEEALCISGSLYTISEA 422 Query: 411 MEVIDA 416 EV+ Sbjct: 423 REVLKK 428 >UniRef50_A8ZTL3 FolC bifunctional protein n=1 Tax=Desulfococcus oleovorans Hxd3 RepID=A8ZTL3_DESOH Length = 434 Score = 443 bits (1140), Expect = e-123, Method: Composition-based stats. Identities = 130/423 (30%), Positives = 197/423 (46%), Gaps = 16/423 (3%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 S + + NL I L L + + LG +AGTNGKG+ TL +I Sbjct: 5 SEYQRLIHEMYNLRRFGIKLELTTMQRMLDALGRPHTRYETIHIAGTNGKGSIATTLATI 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD-ISLTYFEYGTL 129 L AAGY+ G+Y+SPHLV + ER+++ + + +A + + GD T+FEY T Sbjct: 65 LHAAGYRTGLYTSPHLVTFNERIQINNRPVSNAAVVRACKAVRGLSGDGREPTFFEYTTA 124 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 A +LF + +D+ ++E G+GGR DATNI+ ++V+++I+++H +LG I EKA Sbjct: 125 MAFYLFAELGVDIAVIETGMGGRFDATNIITPCLSVISNISVEHRMYLGNTLGEIAGEKA 184 Query: 190 GIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSV-TDHDWAFSDAHGTLE 246 GI + P + G + + I VA+++ A L R G E+ D +++ + Sbjct: 185 GIIKPGVPVVTGARQKPVLDVIKKVAKKQAAPLYRLGGEFRVRRHGDGTFSYHGISHRWD 244 Query: 247 NLPL---PLVPQPNAATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 L NAA ALA L ASG +SE +R G+AS P R +IVS+SP ++ Sbjct: 245 RLRTVLAGGFQMDNAALALAGCELLMASGKPLSEATVRKGLASTRWPARLEIVSDSPTIL 304 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 D AHN AA+ L + ++ V G+L DK L L + D + Sbjct: 305 IDGAHNLQAAKNLAAFLSEQMAGRKITLVAGILDDKPYRAMLRALVPLCDRVILTRAQIG 364 Query: 361 RGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADA-KAEDTVLVCGSFHTVAHVMEVI 414 R E L N D V +A A+A K V V GS + I Sbjct: 365 RAIAPEILEREARNLGATRTHVVDRVDKALAFALAHTPKKSGAVCVAGSLYVAGEARHAI 424 Query: 415 DAR 417 + Sbjct: 425 KKQ 427 >UniRef50_C7H9L3 Tetrahydrofolate synthase n=2 Tax=Faecalibacterium prausnitzii RepID=C7H9L3_9FIRM Length = 423 Score = 442 bits (1139), Expect = e-123, Method: Composition-based stats. Identities = 127/418 (30%), Positives = 196/418 (46%), Gaps = 18/418 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+Y+ + GL R + LG VAGTNGKG+T L S L Sbjct: 3 YEEALNYIHAVQWAGHKPGLTRTRTLLTALGDPHKQLRFIHVAGTNGKGSTAAMLASCLQ 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS--LTYFEYGTLS 130 AAGY+VG+Y+SP + R+ ER++V GQ++P+ A ++ A ++ T FE T Sbjct: 63 AAGYRVGLYTSPFINRFNERIQVNGQQIPDEALVRLVERVKPAADAMTDIPTEFEIITAL 122 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKA 189 + F + + D+V+LEVGLGG LD+TN++D AV+T++ +DH LGP I KA Sbjct: 123 GMLWFAETKCDIVVLEVGLGGTLDSTNVIDPPECAVITALGMDHVKELGPTLADIASAKA 182 Query: 190 GIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDW-AFSDAHGTLE 246 GI + P + G PE + IA A E+ A L + ++ D D A + L Sbjct: 183 GIIKPGSPVVSYGGVPEADAVIARTAAERHAPLTVVDLS-RLTIEDGDLDAVTFDFDGLN 241 Query: 247 NLPLPLVPQPN---AATALAALRAS---GLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 + LPL+ AATA+ ALR G + ++AIR G+ PGRF+++ SP + Sbjct: 242 GIRLPLIGSYQPRNAATAITALRVLRSRGWNIPDSAIRAGLEQVRWPGRFELLRHSPAFL 301 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 D +HN H ++ + + ++ ++ DKD+ LA L + + P Sbjct: 302 LDGSHNAHGMRATVQSLRDRFPGQKFVFLLSIMADKDVDEMLALLLPLAGQFVTVAAHTP 361 Query: 361 RGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 R AE L E + G + ++ A+A V G+ + V E Sbjct: 362 RAMPAETLAEQIRARGGRAEPAPTIEAGVARAVALGGTG-PVCALGTLYFSGDVREAF 418 >UniRef50_B0VF02 FolC bifunctional protein n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VF02_9BACT Length = 426 Score = 442 bits (1137), Expect = e-122, Method: Composition-based stats. Identities = 132/419 (31%), Positives = 209/419 (49%), Gaps = 18/419 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 +L ++ +S + L L R+ + +G + F + GTNGKG+ C TLE++ Sbjct: 3 YNEFLEHIFKRYSGNVKLELNRMQGLLNDMGNPERKLNGFHIGGTNGKGSVCATLEALCR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 +G + +SPHL+ Y ER R+ G+E +F E+ ++FE T A Sbjct: 63 ESGLNTALNTSPHLINYNERFRINGKEPSFETILNTFLRYENLFDKWEASFFEITTALAF 122 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +F + +DV I+EVGLGGRLDATN+ DVAV+T+I LDH LG E I EKAGI Sbjct: 123 SMFSEHNVDVSIIEVGLGGRLDATNLFIPDVAVITNIGLDHIKTLGGTLEIIAGEKAGII 182 Query: 193 RSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDH-----DWAFSDAHGTL 245 + P ++G+ E S I VA+ K + R +W S+ + ++ +S + Sbjct: 183 KEGIPLVLGDIEESPRSIIEAVAKTKKVPVFRYKRDWQTSIRNDNLTGINFDYSFGNYEF 242 Query: 246 ENLPLPLVPQPNAAT---ALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 NL L+ + A AL A L V+E IR + GR Q++S+ P Sbjct: 243 PNLEANLMGEHQAINIGSALTAFILYAEKKKLPVAEEVIRKALQHISWKGRMQLLSQKPI 302 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 +I D AHN H + L ++ + N +V ++ +L DKD L+ + + Y A + Sbjct: 303 IIIDGAHNVHGVKALMSTLEKIFPNRKVKFMVSILRDKDYKQMLSLICPKAEQIYVARNQ 362 Query: 359 GPRGATAEQ----LLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 R A+ E + E+ K+ +VA+A+ A+ + K +D ++VCGS TV V+E+ Sbjct: 363 SERAASVEDQVAVIEEYNIPYKTAPTVAEAYSLAVKECKEDDILIVCGSLFTVGEVLEI 421 >UniRef50_Q0A999 FolC bifunctional protein n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A999_ALHEH Length = 437 Score = 440 bits (1133), Expect = e-122, Method: Composition-based stats. Identities = 180/439 (41%), Positives = 248/439 (56%), Gaps = 27/439 (6%) Query: 5 RTPQAASP--------LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAG 56 TP +A+P L WL + E L I+ GLERV V RLG L P V TVAG Sbjct: 3 DTPGSAAPMPQRDRWRLEDWLRWQEGLSPVEINPGLERVQAVGERLGALTPRCPVITVAG 62 Query: 57 TNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR 116 TNGKG+ LE++L AAGY+ Y+SPHL+RY ER+R+ G + + A TA+F+ +E AR Sbjct: 63 TNGKGSCIAYLEAMLGAAGYRTAAYTSPHLLRYNERIRLAGVPVSDEAITAAFSRVEQAR 122 Query: 117 GDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDW 176 LTYFEYGTL+AL LF +A+ +V +LEVG+GGRLDA N VD D++++TSI LDHT+W Sbjct: 123 QGTPLTYFEYGTLAALSLFSEAEAEVWLLEVGMGGRLDAVNAVDPDLSIITSIGLDHTEW 182 Query: 177 LGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDW 236 LG DRE IG EKAGI R +P +G+ ++P +++D A+ A + G ++++ W Sbjct: 183 LGADRERIGAEKAGIMRPGRPVCLGQADLPDSVSDRARTLRAPVTAAGRDFHWRRQALGW 242 Query: 237 AFSDAHGTLENLPLPLV----PQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRF 290 + L+ LP P + NAA +A LR L V A+ G+ SA LPG Sbjct: 243 DWLSGDERLDGLPWPGLTGTVQLDNAAVVIAGLRRLRERLPVDRAALERGLRSARLPGHM 302 Query: 291 QIV-SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 + V +FDVAHN + L ++ GRV+ + +H K ++G LA + +VV Sbjct: 303 ERVRRRGVEWLFDVAHNEDSVRVLAETVRDEAGKGRVIGLFAAMHRKALSGVLATMGAVV 362 Query: 350 DDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQ-----AWDAAMAD-AKAEDTVLVCGS 403 D+WY LE P+ E + L SV A AA+AD A+ D V+V GS Sbjct: 363 DEWYLPRLEDPQAHPPEAVAAGLRETGVDASVIHTGGLSALLAAVADRARPGDRVVVFGS 422 Query: 404 FHTVAHVMEVIDARRSGGK 422 F TV VM R+GG+ Sbjct: 423 FRTVEAVM------RAGGR 435 >UniRef50_Q71ZB7 FolC bifunctional protein n=12 Tax=Listeria RepID=Q71ZB7_LISMF Length = 429 Score = 440 bits (1133), Expect = e-122, Method: Composition-based stats. Identities = 104/431 (24%), Positives = 200/431 (46%), Gaps = 25/431 (5%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 + L ++ I GL R+ + +L + A +AGTNGKG+T + Sbjct: 2 TLNSYEEALDWIHGTLRLGIKPGLARMEYMMEKLNHPEKANKWVHIAGTNGKGSTLTFVR 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLT 122 + L AGY+ G ++SP++ + ER+ + G+ + + + I+ ++ + Sbjct: 62 NALEEAGYRTGTFTSPYIEVFNERISINGEPISDEMIVSLANRIKPIAEELEKTIYGPPS 121 Query: 123 YFEYGTLSALWLFKQA-QLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 FE T F + +D+ I+EVGLGGRLD+TNI+ ++V+T+I +DH ++LG Sbjct: 122 EFEIITAMMFLCFAEYVSIDIGIIEVGLGGRLDSTNILVPLISVITTIGMDHMEFLGDTI 181 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS 239 E I EKAGI + P + G + E IA +A++ + + + + + + + Sbjct: 182 EQIASEKAGIIKPGIPVVSGAIQKEAQEVIAKIAKKNKSNVAQLNETFFMHNENGNITYK 241 Query: 240 DAHG-TLENLPLPLVPQPN---AATALAALRASG----LEVSENAIRDGIASAILPGRFQ 291 +G + NL + L+ AA A+ L+ E+ AI+ G+ A PGR + Sbjct: 242 TIYGEEISNLSIGLLGLHQLNNAAVAIKVLQYLNTFSTFEIGLAAIKKGLEKAFWPGRME 301 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD- 350 + +P ++ D AHNP + ++ ++ ++ +L DK+ L LKS+ + Sbjct: 302 KIISNPFIMLDGAHNPEGIKTFAHSIQKYSGPKKI--IVSILADKNYQEMLGMLKSIPNT 359 Query: 351 DWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMA---DAKAEDTVLVCGSFHTV 407 + + PR AE++++ N S+ W + + + + + GS + + Sbjct: 360 EIILTTFDYPRAMMAEEVIQIGKNEGI--SLNPDWQQVLGNLYETETNTKIFITGSLYFI 417 Query: 408 AHVMEVIDARR 418 + V + + A + Sbjct: 418 SEVRKYLLASK 428 >UniRef50_Q3AF86 Folylpolyglutamate synthase n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=Q3AF86_CARHZ Length = 432 Score = 440 bits (1133), Expect = e-122, Method: Composition-based stats. Identities = 116/429 (27%), Positives = 186/429 (43%), Gaps = 23/429 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L +L NL I+LGL R+S + RLG + V + GTNGKG+ C S+L Sbjct: 3 YNEALEFLSNLTKFGINLGLGRISELLKRLGNPQEKVKVVHIGGTNGKGSVCSLTASVLA 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEY 126 AGYK G+++SPHL RYTER ++ G+E+ + EI G T FE Sbjct: 63 EAGYKTGLFTSPHLSRYTERYKINGKEISPERVSQLVTEIRPLLLAMVEEGFEHPTEFEV 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIG 185 T A F + ++D V+LEVGLGG +D+TN+V +V +T++ +DH D+LG I Sbjct: 123 STAMAFKYFAEEEVDFVVLEVGLGGLIDSTNVVSRPEVVAITNVGMDHMDYLGNTITEIA 182 Query: 186 REKAGIFRSEKPAIVGEP-EMPSTIADVAQEKGALLQRRGVEWNY-----SVTDHDWAFS 239 R KAGI + P + E I +VA+EK + L + S+ + Sbjct: 183 RVKAGIIKPGVPVVTAATGEALEVIKEVAKEKNSPLLDVNKDIVLNLKEKSLKGQVFDLI 242 Query: 240 DAHGTLENLPLPLVPQPNAATA-----LAALRASGLEVSENAIRDGIASAILPGRFQIVS 294 T + + L+ A + + + AI G ++A GRF+ + Sbjct: 243 YRGETYPEIKIRLLGAHQLLNAKTSFGILNILREKYNIPVEAIYRGFSNATWSGRFEYIP 302 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 +P V+ D AHN L + + ++G+L DK+ +A L + + Sbjct: 303 GNPPVLLDGAHNHDGVRALRQAFTDYFPGVKPVLLLGVLADKEREKVVAELLDLPLEVVV 362 Query: 355 APLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKA-EDTVLVCGSFHTVAH 409 PR L K + +A + A+ + +L+ GS + + Sbjct: 363 TRPPTPRAGDITVLARLFKEKGVRVKVIEEPTEALSYGLEIAQEYQTLLLITGSLYMIGE 422 Query: 410 VMEVIDARR 418 + ++ R Sbjct: 423 IRPLLLQDR 431 >UniRef50_B5EAK4 FolC bifunctional protein n=6 Tax=Geobacter RepID=B5EAK4_GEOBB Length = 424 Score = 439 bits (1131), Expect = e-122, Method: Composition-based stats. Identities = 134/418 (32%), Positives = 205/418 (49%), Gaps = 14/418 (3%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 A LS++ L + GL R+S + A LG + V GTNGKG+T L SIL Sbjct: 2 TYAETLSHIYALGRFGMKPGLSRISPLLAALGNPQERFRSVHVVGTNGKGSTASFLSSIL 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 A GY+ G+++SPHL+ +TER+R+ G E+ + A + +A S T+FE T A Sbjct: 62 SAGGYRTGLFTSPHLISFTERIRIDGNEISQEDVVLVAARVMAAAPPES-TFFEIVTALA 120 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 + F + ++V + E G+GGRLDATN +D + VT I+L+HT++LG I +EKAGI Sbjct: 121 VLYFAEKGVEVAVFEAGMGGRLDATNALDGILCAVTPISLEHTEYLGETLAEIAQEKAGI 180 Query: 192 FRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 + P + ++ + IA A E G+ L R+ ++ + TL++L Sbjct: 181 CKPGAPLVSASQHADVEAAIATRADEIGSPLYRQQESFDAFWQGERLCYRGIGVTLDDLK 240 Query: 250 LPLVPQPNAATALAALRA------SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 + L + A AL G + A+ G+A A PGR ++ PRV+ D Sbjct: 241 VGLFGRYQRGNAALALAVAELLGGLGFPLPPQAMAAGMARAFWPGRMELFPGPPRVLLDG 300 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 AHNP A L + +P+ R+ V+G++ DK++ G L L + D +C R Sbjct: 301 AHNPAGANALAEALAEVPR-ARLFMVVGVMGDKELGGILGPLLPMADQVFCVTPALERAL 359 Query: 364 TAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 AE++ + SV Q A + A ED +LVCGS TV + +R Sbjct: 360 PAEEIARFCLAAGVPAQEAGSVTQGVQQAQSAAADEDLILVCGSLFTVGEARGYLLSR 417 >UniRef50_A6FEP3 Dihydrofolate synthase / folylpolyglutamate synthase n=1 Tax=Moritella sp. PE36 RepID=A6FEP3_9GAMM Length = 441 Score = 439 bits (1131), Expect = e-122, Method: Composition-based stats. Identities = 206/439 (46%), Positives = 270/439 (61%), Gaps = 27/439 (6%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 + + + LA WL YLE++H I++GL R+ VAA L + A V TVAGTNGKG+ Sbjct: 1 MLNSINKSQSLADWLCYLESIHPVNIEMGLGRIGRVAADLALTTFAAKVITVAGTNGKGS 60 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 TC LE IL+ AG+ VGV SSPH+ Y ERVRV G+ L AH SFA IE+ RGD +LT Sbjct: 61 TCAFLERILLDAGFNVGVTSSPHIQDYRERVRVNGKMLTAQAHADSFAFIEAGRGDTTLT 120 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+ TLS+L LF+ A LDVVILEVGLGGRLDA+NIV ADVAVVT+I +DH DWLG D+ Sbjct: 121 YFEFTTLSSLKLFQDAALDVVILEVGLGGRLDASNIVSADVAVVTTIDIDHADWLGTDKA 180 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 I REKAGIFR+ K AI G PSTIA A+E GA L ++ Y+ W + Sbjct: 181 VIAREKAGIFRAGKKAICGVINPPSTIAAYAEEVGADLIAVNRDYYYTQHADTWDWQSNP 240 Query: 243 GTLEN--------LPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS 294 ++ L +P +P NAATA+AA++A GL V + AI G+ASA LPGR Q + Sbjct: 241 TEQQDASALTFTALEIPQLPLQNAATAIAAIQALGLTVPDTAIHSGVASARLPGRMQQLG 300 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNG----RVLAVIGMLHDKDIAGTLAWLKSVVD 350 SP+ DVAHNP +A YL ++ L + +++AV+GML DKDIA +LA L V+D Sbjct: 301 TSPQQFLDVAHNPESARYLASQLTRLKQQASSPVKIIAVVGMLKDKDIAASLAALTDVID 360 Query: 351 DWYCAPLEGPRGATAEQLLEHL---------------GNGKSFDSVAQAWDAAMADAKAE 395 W+ A L+G R A +Q+ + L S D++A+AW +A A Sbjct: 361 CWHLAALQGERAAPCQQIEQGLVAAMQQNSKSRDSLRQQPMSHDTIAKAWQSANQSADCN 420 Query: 396 DTVLVCGSFHTVAHVMEVI 414 D ++ GSF TVA +++ I Sbjct: 421 DIIIGFGSFFTVAEIIQHI 439 >UniRef50_B8DHJ7 Folylpolyglutamate synthase (Folylpoly-gamma-glutamatesynthetase) (Fpgs) (Tetrahydrofolate synthase)(Tetrahydrofolylpolyglutamate synthase) n=3 Tax=Listeria monocytogenes RepID=B8DHJ7_LISMH Length = 431 Score = 439 bits (1131), Expect = e-122, Method: Composition-based stats. Identities = 109/429 (25%), Positives = 200/429 (46%), Gaps = 27/429 (6%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 + L ++ I GL R+ + +L + A +AGTNGKG+T + Sbjct: 2 TLNSYEEALDWIHGTLRLGIKPGLARMEYMMEKLNHPEKANKWVHIAGTNGKGSTLTFIR 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLT 122 + L AGYK G ++SP++ + ER+ V G+ + + + I+ ++ + Sbjct: 62 NALEEAGYKTGTFTSPYIEVFNERISVNGEPISDELIVSLANRIKPIAEELEETIYGPPS 121 Query: 123 YFEYGTLSALWLFKQA-QLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 FE T F + +D+ I+EVGLGGRLD+TNI+ ++V+TSI +DH ++LG Sbjct: 122 EFEIITAMMFLCFAEYVSIDIGIVEVGLGGRLDSTNILMPLISVITSIGMDHMEFLGDTI 181 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS 239 E I EKAGI + P + G + E IA++A + + + ++ + + Sbjct: 182 EQIASEKAGIIKPGVPVVSGAIQKEAQEVIAEIATNNKSNVAQLYDSFSMVNKNGVITYK 241 Query: 240 DAHG-TLENLPLPLVPQPN---AATALAALRASG----LEVSENAIRDGIASAILPGRFQ 291 +G + +L + L+ AA A+ L+ + +AIR+G+ A PGR + Sbjct: 242 TIYGEEINDLSIGLLGIHQLNNAAIAIKVLQYLNTFSSFTIELSAIRNGLEKAFWPGRME 301 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD- 350 V +P ++ D AHNP ++ P+ ++ V+ +L DK+ L L+++ + Sbjct: 302 KVMSNPFIMLDGAHNPEGINTFARSIEMYPEPKKI--VVSILADKNYQEMLTTLRAISNS 359 Query: 351 DWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMA-----DAKAEDTVLVCGSFH 405 + PR T E++L+ SV W A+ +++++ + V GS + Sbjct: 360 EIILTTFNYPRAMTTEEVLQIGEEEGI--SVNPNWQQALNNLYKGESESDAKIFVTGSLY 417 Query: 406 TVAHVMEVI 414 ++ V + Sbjct: 418 FISEVRNYL 426 >UniRef50_B8I1X5 FolC bifunctional protein n=2 Tax=Clostridium RepID=B8I1X5_CLOCE Length = 424 Score = 439 bits (1131), Expect = e-122, Method: Composition-based stats. Identities = 113/422 (26%), Positives = 198/422 (46%), Gaps = 27/422 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + L YL GL+R++ + +G +AGTNGKG+T + SIL+ Sbjct: 3 YEAALEYLHGTLKFGSIFGLDRITKLLDLMGNPHKKLKFIHIAGTNGKGSTTAFISSILI 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEY 126 AGY+ G+++SP++ R+TER++V E+ ++I++ G T FE Sbjct: 63 EAGYRTGMFTSPYIQRFTERIKVDNNEISNDELAELISQIKNCIEKMVSNGFEHPTEFEI 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIG 185 T +++ F + + D+V+LEVGLGG +D+TN++D + +VVTSI++DH D LG I Sbjct: 123 ITAASMEYFYKKKCDIVVLEVGLGGIVDSTNVIDTPEASVVTSISMDHMDRLGETLGEIA 182 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGV----EWNYSVTDHDWAFS 239 +KAGI + + ++ E E I V++EK A + + + +S+++ + + Sbjct: 183 YQKAGIIKQDGVVVLYPQEQEAEEVIERVSKEKNAQIHKVDFSTIYDKGFSLSEQIFDYK 242 Query: 240 DAHGTLENLPLPLVPQPNAATALAA------LRASGLEVSENAIRDGIASAILPGRFQIV 293 D N+ + L+ A A L G ++ I DG+ PGR +I+ Sbjct: 243 D----YRNIKIGLLGDHQMRNAAVAIDTCELLCNKGFALTHRNILDGLEKTRWPGRLEII 298 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 +++P V+ D AHN + L + + + V+G L DKD G + L + D Sbjct: 299 NKNPLVLIDGAHNLEGGQALNTALDKYFTQKKKIFVVGFLRDKDYIGIMDMLGNKADTII 358 Query: 354 CAPLEGPRGATAEQLLEHLGNGKSFD----SVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 R + +L E L + + S+ A+ A +E + GS + + Sbjct: 359 TVTPNNERAVPSAELAEILKSYSNHVVDGMSIENGLQTAVGLADSESVICAFGSLYMIGE 418 Query: 410 VM 411 + Sbjct: 419 IR 420 >UniRef50_C0ZAJ3 Folylpolyglutamate synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0ZAJ3_BREBN Length = 457 Score = 439 bits (1129), Expect = e-121, Method: Composition-based stats. Identities = 138/447 (30%), Positives = 197/447 (44%), Gaps = 37/447 (8%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 + L +L L GLER+ V ++G + VAGTNGKG+TC Sbjct: 2 HAEEGFVEYTQALDWLHGLLRFGQRPGLERMQWVLEQVGHPERRIPFIHVAGTNGKGSTC 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI-------ESARG 117 L +LM AGY VG ++SP+LV + ER+R G + E E+ E Sbjct: 62 AFLTQMLMEAGYSVGTFTSPYLVDFRERIRYNGSMIAEEDLLQLVNEVKVWVQRCEQETE 121 Query: 118 DISLTYFEYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDW 176 S T FE TL A+ F + A+ VV+ E GLGGRLD+TN+V V+V+T+I +DHT Sbjct: 122 YGSPTEFEVITLIAILYFSRVARPAVVVWETGLGGRLDSTNVVLPLVSVITNIGMDHTQV 181 Query: 177 LGPDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNY----- 229 LG E I REKAGI + P + GE PE+ + + A++ + L G + Sbjct: 182 LGESLEDIAREKAGIIKPGVPVVTGEVRPELLAVFEERARQMKSTLYHIGEHFQAEQVEE 241 Query: 230 SVTDHDWAFSDAHGTLE---NLPLPLVPQ-PNAATALAALRASG----LEVSENAIRDGI 281 + D + + H E L + + Q NAA AL + + E I G+ Sbjct: 242 QLGDQQFGYKSIHRRAEASYRLTMNGIHQTTNAAVALMTIDVLRNYFSFLLEEEEISRGL 301 Query: 282 ASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNG-RVLAVIGMLHDKDIAG 340 PGR +++S P VI D AHN E L + L +G ++ + L DK +A Sbjct: 302 QQTRWPGRLEVISPRPMVILDGAHNQEGMEALVSSLDRLLPDGVQLHLLFSGLADKPLAK 361 Query: 341 TLAWLKSV---VDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQA----------WDA 387 L V + + + PR A A L E G A W Sbjct: 362 MAESLAPVKSKMKKLHVTTFDFPRAAEANSLQESFLAGGWEQEFLDAVPDWRAFLLSWMR 421 Query: 388 AMADAKAEDTVLVCGSFHTVAHVMEVI 414 AKA+D ++VCGS + +A V Sbjct: 422 EKQLAKADDWLVVCGSLYFIAQVRAFF 448 >UniRef50_A6TN35 FolC bifunctional protein n=2 Tax=Alkaliphilus RepID=A6TN35_ALKMQ Length = 439 Score = 438 bits (1128), Expect = e-121, Method: Composition-based stats. Identities = 121/428 (28%), Positives = 199/428 (46%), Gaps = 24/428 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+Y+ + + LGL+ + + L V VAGTNGKG+ + S+L Sbjct: 3 YEQALTYIHDTYKFGRKLGLDNIKYLLNLLDNPHQKVKVIHVAGTNGKGSIASLIHSVLK 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 GY+VG+Y+SP+L +TER+R+ G+++P E++ ++ T FE Sbjct: 63 TQGYRVGLYTSPYLEEFTERIRISGEDIPRERLAQVTEEVKMKIEEMVKSGQNHPTEFEV 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIG 185 T A + Q ++D V+LEVGLGGRLDATN+++ ++++T I DHT +LG + I Sbjct: 123 VTAIAFLYYAQEEVDFVVLEVGLGGRLDATNVINTPLLSIITPIGYDHTAYLGNTLKEIA 182 Query: 186 REKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVE----WNYSVTDHDWAFS 239 EK G+ + + +V E + ++QE+ L ++ ++ + ++ Sbjct: 183 FEKGGVIKEDGLTLVAPQEEEALQVLKKLSQERNNQLFMTNLQGLEIKKSTIEEQVFSCE 242 Query: 240 DAHGTLENLPLPLVPQPNA---ATALAAL----RASGLEVSENAIRDGIASAILPGRFQI 292 EN+ + L+ TAL A+ +EVS+ +I GI PGR ++ Sbjct: 243 TYARAYENVEIKLLGAHQIENCCTALTAIDILKEHHDIEVSDESIYQGILETRWPGRMEV 302 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 V + P VI D AHN + L +K L R+ V+GML DK++ G L L +VD Sbjct: 303 VQDEPTVIIDGAHNLQGGQALANTLKQLLSGRRITFVMGMLEDKEVDGFLNELIPLVDIV 362 Query: 353 YCAPLEGPRGATAEQLLEHLGNGK----SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 PR A L + K V +A + +A +D +L GS + + Sbjct: 363 IATTPNSPRSMPANVLAGKMDVFKKPIHVEAEVRKAIEKGLALTGKDDVLLFAGSLYMIG 422 Query: 409 HVMEVIDA 416 V + Sbjct: 423 EVRSYFKS 430 >UniRef50_C7MLS9 Folylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Coriobacteriaceae RepID=C7MLS9_CRYCD Length = 466 Score = 438 bits (1127), Expect = e-121, Method: Composition-based stats. Identities = 140/448 (31%), Positives = 212/448 (47%), Gaps = 36/448 (8%) Query: 3 IKRTPQAASPLASW--LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 I T A + ++ ++YL ++ LGLER+ + A LG + V VAGTNGK Sbjct: 23 ISDTIDTADAVDTFDPIAYLNEPRWRSSRLGLERIESLMAALGNPQDKLTVVHVAGTNGK 82 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--D 118 G+TC + S+L AGY+ G+++SP+++ +T+R+R+ GQ + +A A+ + D Sbjct: 83 GSTCAMVASVLQHAGYRTGLFTSPYIIEFTDRIRIDGQNVSLAALCAATQTVRRVAEQMD 142 Query: 119 ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWL 177 T FE T A F A + ++EVGLGGRLD+TN++ A V + I+ DHTD L Sbjct: 143 DHPTEFELMTAVAFVCFVAAGCTMAVVEVGLGGRLDSTNVIAAPAVCALAPISFDHTDIL 202 Query: 178 GPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD 235 G I EKAGI + + PE I + A + G+ + E S T Sbjct: 203 GSTLAQIAHEKAGIIKPGAAIVSALQRPEAMRVIENAALQVGSPVTVVD-EQRLSGTPAH 261 Query: 236 WAFSDAHGTLENLPLPL---VPQPNAATALA---ALRASGLEVSENAIRDGIASAILPGR 289 +++ +L +PL NAA A+ AL G+ ++E +R+G+A PGR Sbjct: 262 FSYRS----YTDLSIPLKGSYQTHNAALAIEAIDALIQKGITITEQDLREGLAQVSWPGR 317 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 FQ+VS SP I D HNP A+ L ++A R + +IG+L DKD+ L + Sbjct: 318 FQVVSHSPEFIVDGGHNPQGAQALVDSLEANYPARRTVLLIGVLADKDVTSMLRRVLPSG 377 Query: 350 DDWYCAPLEGPRGATAEQLL------------------EHLGNGKSFDSVAQAWDAAMAD 391 C PR A++L E L N S+ Q A Sbjct: 378 CGVVCITPPNPRALGAQELASQVVSLAKQLQNESIAIDERLLNPVCAPSIGQGVTCAQQM 437 Query: 392 AKAEDTVLVCGSFHTVAHVMEVIDARRS 419 A AE V GS +++A +M +D + Sbjct: 438 AGAEGLVCAFGSLYSIADIMAALDKHSA 465 >UniRef50_A5I6P2 FolC bifunctional protein n=14 Tax=Clostridia RepID=A5I6P2_CLOBH Length = 429 Score = 438 bits (1127), Expect = e-121, Method: Composition-based stats. Identities = 108/429 (25%), Positives = 197/429 (45%), Gaps = 28/429 (6%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 Y+++ +LGLER + LG +AGTNGKG+T + ++L Sbjct: 2 DYKEAREYIQSKAKFGSNLGLERTEKLLELLGNPHKRLRCIHIAGTNGKGSTTAMISAVL 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LTYFE 125 +GYKVG+Y+SP++ + ER+++ G + + ++ + + T FE Sbjct: 62 KESGYKVGMYTSPYIEEFEERIQINGHNITKEDLGYIITKVANIVEKVENMGYGNPTEFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T++ + F ++D ++EVGLGGRLD+TN+++ ++++TSI+ DH + LG E I Sbjct: 122 IITVAMFYYFCLKEVDFAVIEVGLGGRLDSTNVLEPILSIITSISYDHMNILGETLEEIT 181 Query: 186 REKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNY--------SVTDHD 235 EKAGI + P I E+ I V +EK L + ++ Sbjct: 182 YEKAGIIKK-APVITYPQKKEVEKNIEKVCKEKNCELIKVEDNLINIEIEIIEKNMGQQS 240 Query: 236 WAFSDAHGTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGR 289 + T N+ L L+ + AL L G+++ + I + P R Sbjct: 241 FKLKTKEDTY-NICLSLLGEHQIKNCITVILALEKLMKLGIKIEKIHIISALKKVKWPAR 299 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 +IV+++P + D AHN E L + K +++ ++G+L DK + + L + Sbjct: 300 LEIVNKNPLTVIDGAHNIDGIESLKNNVSKYFKYNKLILILGILKDKQVEDMIKTLVPLA 359 Query: 350 DDWYCAPLEGPRGATAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 D RG ++++L L+H + + + + +D A + D +L+CGS + Sbjct: 360 DRVLTVAPHNDRGESSKELMHIVLKHNESCEHLEDYKECYDKAKFYCEDGDMILICGSLY 419 Query: 406 TVAHVMEVI 414 V + ++I Sbjct: 420 MVGDMRKLI 428 >UniRef50_A0AJ00 FolC protein n=2 Tax=Listeria RepID=A0AJ00_LISW6 Length = 429 Score = 437 bits (1124), Expect = e-121, Method: Composition-based stats. Identities = 111/438 (25%), Positives = 197/438 (44%), Gaps = 38/438 (8%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M +K +A L ++ I GL R+ + +L + A +AGTNGK Sbjct: 1 MTLKSYEEA-------LEWIHGTLRLGIKPGLARMEYIMEKLNHPEKANKWIHIAGTNGK 53 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI- 119 G+T + + + AGY G ++SP++ + ER+ V G+ + + ++ ++ Sbjct: 54 GSTLTFIRNCIEEAGYTTGTFTSPYIETFNERISVNGKPISDDKILILANRMKPIAEELK 113 Query: 120 -----SLTYFEYGTLSALWLFKQAQ-LDVVILEVGLGGRLDATNIVDADVAVVTSIALDH 173 + FE T F + +D+ I+EVGLGGRLD+TNI+ V+V+T+I +DH Sbjct: 114 NTIYGPPSEFEIITAMMFLYFAEYDSIDIGIIEVGLGGRLDSTNILLPLVSVITTIGMDH 173 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSV 231 ++LG E I EKAGI + P I G + E I +A + A + ++ + Sbjct: 174 MEFLGNTIEEIASEKAGIIKPGTPVISGVIQSEAQEVIKAIASKNKANFAQLNQDFFIQL 233 Query: 232 TDHDWAFSDAHG-TLENLPLPL---VPQPNAATALAALRASG----LEVSENAIRDGIAS 283 F HG + +L L NA+ A+ ++ ++ E AI+ G+ Sbjct: 234 DGKTATFKTKHGEEIVDLVTGLDGFHQLNNASLAIKVIQYLNTYSLYDIDEKAIKAGLKK 293 Query: 284 AILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA 343 A PGR + + E P +I D AHNP E L + + + ++ +L DK+ L+ Sbjct: 294 AFWPGRMETILEKPLIIVDGAHNPEGIETLKHSINRFSGHK--IIIVSILKDKNYKEMLS 351 Query: 344 WLKSVVD-DWYCAPLEGPRGATAEQ------LLEHLGNGKSFDSVAQAWDAAMADAKAED 396 LKS+ D + + R +A++ L + N D++ +K + Sbjct: 352 SLKSIPDCEIILTTFDYSRAMSAQETINVGKLEDIAVNPVWHDAINDTVQ-----SKNDS 406 Query: 397 TVLVCGSFHTVAHVMEVI 414 + + GS + ++ V + + Sbjct: 407 KIFITGSLYFISEVRKFV 424 >UniRef50_C8QY00 FolC bifunctional protein n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QY00_9DELT Length = 453 Score = 436 bits (1122), Expect = e-121, Method: Composition-based stats. Identities = 130/444 (29%), Positives = 195/444 (43%), Gaps = 41/444 (9%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 +W YL+ L I LGL+ + ARLG + VAGTNGKG+ L ++L Sbjct: 5 QAW-DYLDRLQFFKIKLGLDSMERFLARLGKPQQQLRFIHVAGTNGKGSVAAALLAVLSR 63 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALW 133 AGY+VG+Y+SPHL ER R+ + + + I GD +TYFE+ T AL Sbjct: 64 AGYRVGLYTSPHLSCVRERFRINDEFIGKDEFARHATAIHEVLGDDQITYFEFTTALALL 123 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F ++DV ILEVGLGGRLDATN++ +V V+T+++LDH +LG + EKAGI + Sbjct: 124 WFAARRVDVAILEVGLGGRLDATNVITPEVGVITNVSLDHQAYLGDTLAEVAAEKAGIIK 183 Query: 194 SEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD---------------- 235 + P + G E + + A G ++++ D Sbjct: 184 AGVPLVTGVAADESREVVEQRCRLLKAPCYLLGRNFSWAYGDDRQARQDSAQSVSDSAAA 243 Query: 236 -----WAFSDAHGTLENLPLPLVPQPNAATALAALRASG-----LEVSENAIRDGIASAI 285 W + +G + L L + AL V+E +IR GIA+ Sbjct: 244 AAGNLWHYRGLNGEISGLQCRLRGRHQRDNLSLALATLELLAPIWPVTEESIRAGIAAVN 303 Query: 286 LPGRFQIVSESP-------RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDI 338 PGR + + P RV+ D AHNP L G ++ R++ V + DKD+ Sbjct: 304 WPGRLEYLEIRPAGADGRRRVLLDGAHNPAGIGALVGALQEDFSYRRLVVVWASMADKDV 363 Query: 339 AGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG-----NGKSFDSVAQAWDAAMADAK 393 A L + + D+ E R AT + + L + + A A A + Sbjct: 364 AAGLQQIAPLADELVLTRPESERSATPAAMRQMLPPATRTAAREAEDTAGALQLAWQAST 423 Query: 394 AEDTVLVCGSFHTVAHVMEVIDAR 417 +D VLV GS + V ++ Sbjct: 424 PDDLVLVAGSLYLVGAARRLLQGE 447 >UniRef50_Q2LQC5 Folylpolyglutamate synthase / dihydrofolate synthase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LQC5_SYNAS Length = 465 Score = 436 bits (1122), Expect = e-121, Method: Composition-based stats. Identities = 117/408 (28%), Positives = 191/408 (46%), Gaps = 14/408 (3%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 L +L+ I LGL+ + + R+ + + GTNGKG+T L IL +GYK Sbjct: 39 QRLLDLNCNIIRLGLDPIRHLLERMENPQLKYPAVLIGGTNGKGSTAAILSCILKESGYK 98 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQ 137 VG+Y+SPHL ER+R+ G + E F I+S+ + LTYFE T SA F Q Sbjct: 99 VGLYTSPHLTSICERIRINGSLISEERMQDCFGMIQSSLEE-PLTYFEVLTASAYLYFYQ 157 Query: 138 AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKP 197 ++D+ +LEVG+GGRLDATN+V V+V++++ L+H ++LG I EKAGI + Sbjct: 158 EKVDIAVLEVGMGGRLDATNVVTPLVSVISNVHLEHQEYLGRHLRDIAAEKAGIIKENSV 217 Query: 198 AIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT-DHDWAFSDAHGTLENLPLPLVP 254 + + + +++ ++K A L R G + V D +++ L++L L Sbjct: 218 CVTAVTQKAVLDLLSETCRQKEATLYRLGKDIRVRVKGDGTFSYQGIAIKLDDLKCTLSG 277 Query: 255 QPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPH 308 A + G+ V+ A+ G+A A GR +I+ +P V+ D AHNP Sbjct: 278 AHQIKNAALALAAAEVVTTKGIRVNRQAMLSGVACASWDGRLEILQNTPTVLVDGAHNPA 337 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 AA L ++ + L + G L DK+ L L D + R L Sbjct: 338 AANVLCQALRNRNADDHRLLIFGALGDKNYRLMLKKLLPFFDHVIFTKPKTERAVDVADL 397 Query: 369 LEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 + + ++ + +A A+ D + + GS + V + + Sbjct: 398 IRAARHYDRSAEAIEDSCEALQRALCLTGKNDMICITGSLYLVGEIKK 445 >UniRef50_B2J1B6 FolC bifunctional protein n=25 Tax=Bacteria RepID=B2J1B6_NOSP7 Length = 448 Score = 436 bits (1121), Expect = e-120, Method: Composition-based stats. Identities = 131/426 (30%), Positives = 199/426 (46%), Gaps = 27/426 (6%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 ++ + LGL+R+ + A LG V VAGTNGKG+ C L SIL AGY+ G Sbjct: 23 IQPFQRFGVHLGLDRIINLLANLGNPHHQVPVIHVAGTNGKGSVCAYLSSILTEAGYRTG 82 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR--GDISLTYFEYGTLSALWLFKQ 137 Y+SPHLV +TER+ + Q + + +++ D S T FE T +A F Q Sbjct: 83 RYTSPHLVDWTERICLNEQPISSEELSQLLEKVQGVIRPEDESATQFEVITAAAWLYFAQ 142 Query: 138 AQLDVVILEVGLGGRLDATNI-VDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEK 196 Q+DV ++EVGLGGRLDATN+ ++ V ++TSI+ +H LGP I REKAGI + Sbjct: 143 QQVDVAVVEVGLGGRLDATNVCLEPIVTIITSISREHWQQLGPTVADIAREKAGILKPGC 202 Query: 197 PAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVP 254 P +VG+ + + A E + + ++ + + L PLPL Sbjct: 203 PVVVGQLPLDAEEVVRSRALELKCPIFTPQPARQIATGWAEYQ-TLQNSQLIKYPLPLAG 261 Query: 255 QPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDVAHNP 307 Q A AL L+ G +SE AI G+A PGR Q + + +++ D AHN Sbjct: 262 QIQLANSALAIAALEILQEQGWHISEEAIIKGMAKTQWPGRMQWTTWNNHKILLDGAHNT 321 Query: 308 HAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP----R 361 AA+ L + +L + V+GM DKD A A L D + P+ R Sbjct: 322 AAAQVLRQYVDSLDAVNPKPITWVMGMFSDKDHADIFAALLRPGDRLFLVPIPVESWTGR 381 Query: 362 --------GATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 A +L L + + + A + A++ +D +++CGS + V + Sbjct: 382 TSADLDSLANLAYRLCPQLSDRQIHPDLFTALEVAISTTSTDDLIVLCGSLYLVGDFLAT 441 Query: 414 IDARRS 419 + R Sbjct: 442 TNIIRK 447 >UniRef50_C6WVE3 FolC bifunctional protein n=1 Tax=Methylotenera mobilis JLW8 RepID=C6WVE3_METML Length = 458 Score = 435 bits (1119), Expect = e-120, Method: Composition-based stats. Identities = 182/446 (40%), Positives = 254/446 (56%), Gaps = 34/446 (7%) Query: 4 KRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTT 63 L++WL+Y+E LH I++GL R+ VA RL LKP + TVAGTNGKG+T Sbjct: 5 FSLEAPPKDLSAWLTYIEQLHPSAIEMGLGRIKTVADRL-ALKPTFKIITVAGTNGKGST 63 Query: 64 CRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD----- 118 C L I AGY+VG Y+SPH++RY ERV+V GQE +++ A+FA +E+AR Sbjct: 64 CTMLSQIYQHAGYRVGCYTSPHILRYNERVQVNGQEASDASLCAAFAAVEAARLGTANQS 123 Query: 119 --ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDW 176 ISLTYFE GTL+A+W F Q +DV +LE+GLGGRLDA N + D +VT++ LDH D Sbjct: 124 FAISLTYFEIGTLAAVWHFVQTGVDVAVLEIGLGGRLDAVNAFEPDCTIVTNVDLDHQDL 183 Query: 177 LGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDW 236 LG RE IG EKAG++R+ PAI G+ PST+ A+E A L+ E+ Y + D W Sbjct: 184 LGDTRELIGYEKAGVYRASIPAICGDINPPSTLIAYAKEVKADLKCVQHEFGYELADAGW 243 Query: 237 AFSDAHGTLENLPLPLV----PQPNAATALAALRASG--LEVSENAIRDGIASAILPGRF 290 + + + +LP+P + NAA A+ A+ A L V+ +I + L GRF Sbjct: 244 YYLNNQQRVYHLPIPALKGQYQLTNAACAITAVTALQSVLPVALESIVKAMQEIKLMGRF 303 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALP--------KNGRVLAVIGMLHDKDIAGTL 342 P +IFDVAHNPHAA L +K+L + R+L+V ML DKDI G + Sbjct: 304 YTDERFPWLIFDVAHNPHAAVALAENLKSLKSLTSNKSGEPVRILSVFSMLADKDIKGVV 363 Query: 343 AWLKSVVDDWYCAPLEGPRGATAEQLLEHL------GNGKSFDSVAQAWDAA------MA 390 LK VD WY AP+E RG + + L+ + + K+F S+A A+ A Sbjct: 364 EILKGEVDTWYVAPIEHARGTSVKALVTAIHEVIPDASVKTFASLADAYTQAYLDRESCI 423 Query: 391 DAKAEDTVLVCGSFHTVAHVMEVIDA 416 + D ++ GSF TV+ VM+ ++ Sbjct: 424 EQHENDKIVAFGSFFTVSSVMQYLNE 449 >UniRef50_A8UBK8 Folyl-polyglutamate synthetase n=1 Tax=Carnobacterium sp. AT7 RepID=A8UBK8_9LACT Length = 434 Score = 434 bits (1118), Expect = e-120, Method: Composition-based stats. Identities = 110/429 (25%), Positives = 202/429 (47%), Gaps = 23/429 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + L+++ + GL+R+ + +++G + +AGTNGKG+T L + Sbjct: 3 ATYEEALNWIHTTRTFGKKPGLKRMEWMLSQVGHPERKFKSIHIAGTNGKGSTLAFLRGM 62 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYF 124 L A G VG Y+SP++ + ER+ V G L ++ + ++ + F Sbjct: 63 LEANGQIVGTYTSPYIELFNERISVNGDPLSDAEILRLANIVYPLTKELEKTILGEPSEF 122 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T+ L F + DVV++EVG+GG D+TN++ V+V+T+I LDH + LG I Sbjct: 123 EIITMMMLLYFGEGHADVVLIEVGIGGTYDSTNVITPIVSVITTIGLDHMNLLGDTLSEI 182 Query: 185 GREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYS------VTDHDW 236 KAGI ++ P ++G+ E + I + A E+ + L + ++ + + Sbjct: 183 AGNKAGIIKATVPVVIGKIGKEAMTVIENKAAEQDSTLLKYNQDFFVTKWQTLPTWGEQF 242 Query: 237 AFSDAHGTLENLPLPLVPQPN---AATALAALR----ASGLEVSENAIRDGIASAILPGR 289 F D L + + ++ + AA A+ LR +GL ++ + G+ PGR Sbjct: 243 VFEDDFIRLSPIQIEMLGRHQVENAAVAVETLRVYSHETGLAINHEKLLSGLKHTFWPGR 302 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 F+ ++E P ++ D AHN HA + L +K V ++ + DK+I G + L+ + Sbjct: 303 FERINEQPLLVLDGAHNEHAMKTLIETIKKNFAQQEVYIIMATMRDKNIQGMVDQLEEIP 362 Query: 350 D-DWYCAPLEGPRGATAEQLLE-HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 + + PR A E+L + L NG + +A ++ + VLV GS + + Sbjct: 363 NSHLILTSFDYPRAAGIEELSKVALKNGAVTEHWQKALVDSLNEMDETGIVLVTGSLYFI 422 Query: 408 AHVMEVIDA 416 + V + ++ Sbjct: 423 SEVRKYLNE 431 >UniRef50_A6C8Q2 Folyl-polyglutamate synthetase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C8Q2_9PLAN Length = 477 Score = 434 bits (1118), Expect = e-120, Method: Composition-based stats. Identities = 120/458 (26%), Positives = 196/458 (42%), Gaps = 48/458 (10%) Query: 5 RTPQAASPLASWLSY--LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 + Q+ L L+Y + + T D L R+ + LG + +AGT GKG+ Sbjct: 7 KYQQSLDFLFGRLNYERMGSSKYSTSDFKLGRMQELLESLGNPQSEVRTIHIAGTKGKGS 66 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR------ 116 T + +L AAG++ G+++SPH+ Y ER+ + G+++ +E+ Sbjct: 67 TSAMIAEMLSAAGFRTGLFTSPHITCYEERILIDGRQIEPEQLVDLVSELIQVVEQLDLK 126 Query: 117 -GDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTD 175 G++S T+FE T A F+Q ++D ++EVGLGGRLD+TN+ + +VVT+I+ DHT Sbjct: 127 PGNLSPTFFELTTALAWMHFQQQRVDFAVMEVGLGGRLDSTNVCEPLASVVTNISYDHTA 186 Query: 176 WLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT- 232 LG E I REKAGI + P G +PE + + +V +EK A L ++ V Sbjct: 187 LLGNTIEQITREKAGIIKQGVPVFSGVTQPEAMAVLEEVCREKQAPLYLLNRDFKRLVEP 246 Query: 233 -------------------DHDWAFSDAHGTLENLPLPLVPQPNAATALAA------LRA 267 ++ +P+ L+ A A LR Sbjct: 247 YQGFRREQADDSRLFPDSNQQTIQVRTPWSLIDQMPVTLLGTHQLINATLAVTVIDFLRQ 306 Query: 268 SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVL 327 G+ + ++ +R G+ P R ++V ++P V+ D AHN + E L + A + Sbjct: 307 QGVPLEDSQMRQGMTRLKWPARIELVQKNPPVVIDTAHNGASIEALVETLAASFPQTNRI 366 Query: 328 AVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQLLEHLGNGK---------- 376 + DKD+ L L PR E+L+E + Sbjct: 367 LIFAATKDKDVGEMLETLLPSFQTVILTQYRSNPRRIPVEELVELTRAVQLSTGNTSQLS 426 Query: 377 SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 DS AW A + + V GSF A + E++ Sbjct: 427 ITDSPEAAWLQAKDMLTPDTLICVTGSFFIAAELRELL 464 >UniRef50_C9LMI1 Tetrahydrofolate synthase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMI1_9FIRM Length = 440 Score = 434 bits (1117), Expect = e-120, Method: Composition-based stats. Identities = 127/435 (29%), Positives = 196/435 (45%), Gaps = 29/435 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 +S LE I GLER+ + A LG + A + + GTNGKG+ + S+L Sbjct: 3 YQESISRLEEASVFGIKPGLERMQKILAVLGNPEKACKMIHITGTNGKGSVAAMITSVLE 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEY 126 +VG ++SPHL+ YTER+ + G+++ + + A G+ +LT FE Sbjct: 63 NTNLRVGRFTSPHLIDYTERIYLGGKDISREDFAKAATVVFKAHDELVAAGEEALTEFEL 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T A W F++ + D ++EVG+GGR DATN+V V+V+T++A+DH +LG + I R Sbjct: 123 LTAIAFWYFRENKADYAVMEVGMGGRFDATNVVMPVVSVITNVAMDHMQYLGNTLQEIAR 182 Query: 187 EKAGIFRSEKPAIVGEPE-MPSTIADVAQEKGALLQRRGVEWNYSVTDH-------DWAF 238 EKAGI + P + + A K A + G ++ + Sbjct: 183 EKAGIIKEGIPVVTAAQHVALKELKKDAHNKKARIYFYGRDFEIDTRNKWEQGQVVVVKR 242 Query: 239 SDAHGTLEN--LPLPLVP------QPNAATALAALRASGLEVSENAIRDGIASAILPGRF 290 LE L +P + AA AL L ++EN +R+G+A A GRF Sbjct: 243 KGMPKELEKSMLFVPFIGAHQAVNAAVAAMALTILMKEDGRINENDLREGLARARWQGRF 302 Query: 291 QIVSESPR-VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 +I + V+ D AHN AE L ++ + R + V L DK + L Sbjct: 303 EIHHAGGKTVVLDGAHNEAGAEALQEALREQYPDKRRIFVFSSLQDKTTETIIQMLVRKG 362 Query: 350 DDWYCAPLEGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 D Y PR T E++ E + K SVA A + A+ +A D VLVCGS Sbjct: 363 DKVYACAAPTPRTRTPEEICEMIDRQKIRAEHKIAGSVADALEKAVKEADENDIVLVCGS 422 Query: 404 FHTVAHVMEVIDARR 418 + + + + + Sbjct: 423 LYILGDAIRWLRKQE 437 >UniRef50_B7RU63 FolC bifunctional protein n=1 Tax=marine gamma proteobacterium HTCC2148 RepID=B7RU63_9GAMM Length = 431 Score = 434 bits (1117), Expect = e-120, Method: Composition-based stats. Identities = 172/424 (40%), Positives = 242/424 (57%), Gaps = 15/424 (3%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 + LA WL +LE LH ++LGL+RVS VA LG+L + V TVAGTNGKG+T LE Sbjct: 2 TSKTLAQWLQHLETLHPNEMELGLDRVSQVADTLGLLPLSSPVVTVAGTNGKGSTVAVLE 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 S+L G++ G ++SPH +R+ ER+RV G E + A+F IE R ISLTYFE+ T Sbjct: 62 SLLRECGFRPGAFTSPHFLRFNERIRVGGNEAQDEQLIAAFEAIEGVRDGISLTYFEFST 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+AL +F++ ++D V+LEVGLGGRLD+ N+VDAD+AV+TSI LDH DWLG R I REK Sbjct: 122 LAALMVFEREEVDYVLLEVGLGGRLDSANMVDADIAVITSIDLDHQDWLGDTRGVIAREK 181 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGA-LLQRRGVEWNYSVTDHDW-----AFSDAH 242 AGI R KP ++ +PE P + +VA+++ A L R G E+++S W A Sbjct: 182 AGIMRVGKPVVIADPEPPGELLEVARDRAAGPLYRLGQEFDFSGPADRWQGRVQALKGDK 241 Query: 243 GTLENL-PLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR-VI 300 L++L + L+P A A AA+ G+E E+ ++ I +I PGR Q + + Sbjct: 242 KLLQHLSSVSLLPANVCAAAQAAV-LLGVEFGEDQLQRAIDGSIRPGRLQRMELGGFHYL 300 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP-LEG 359 DVAHNP A + L + A P NG+V+A+ + DK I L D W+ + Sbjct: 301 LDVAHNPAAIDKLLENIAASPCNGKVIALFSAMKDKAIDEMLEACSGHFDAWFLGEQPDN 360 Query: 360 PRGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 PR Q+ E L ++ QA+ A ED ++V GSF TVA V+ + Sbjct: 361 PRAMPTAQIAELLREQGQEAISISKNLRQAFRRAQTVMNGEDLLVVFGSFFTVAAVLPQL 420 Query: 415 DARR 418 + R Sbjct: 421 EKDR 424 >UniRef50_Q5CB75 Folylpolyglutamate synthase/dihydrofolate synthase n=11 Tax=Thermotogaceae RepID=Q5CB75_THESQ Length = 437 Score = 433 bits (1115), Expect = e-120, Method: Composition-based stats. Identities = 129/425 (30%), Positives = 208/425 (48%), Gaps = 32/425 (7%) Query: 15 SWLSYLENLHSK----TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 ++L L+ L+ K + GLER+S++ ++LG V GTNGKG+ + I Sbjct: 9 AYLEVLKYLYHKRPMGKVKPGLERISMLLSKLGNPHLKYKSIHVGGTNGKGSVTNMISHI 68 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYF 124 L++ GY+VG Y SPHL + ER+R+ + + E + ++E ++ S ++F Sbjct: 69 LISQGYRVGSYYSPHLSTFRERIRLNEEYISEEDVVKIYEKMEPILNELDKEEIFSPSFF 128 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T A F + +D+ +LEVGLGGRLDATN+V + + ++ DH LG E I Sbjct: 129 EVVTAMAFLYFAEKNVDIAVLEVGLGGRLDATNVVFPLCSTIVTVDRDHEKTLGYTIEQI 188 Query: 185 GREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVT-----DHDWA 237 EK+GI + P + GE E + DVA++K + + +++ V ++ + Sbjct: 189 AWEKSGIIKERVPLVTGERKREALKVMEDVARKKSSRMYVIDKDFSVKVKSLKLHENRFD 248 Query: 238 FSDAHGTLENLPLPL---VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS 294 + T E+L L + NA AL L A+GL +SE AIR+G+ +A GRF+I+ Sbjct: 249 YCG-ENTFEDLVLTMNGPHQIENAGVALKTLEATGLPLSEKAIREGLKNAKNLGRFEILE 307 Query: 295 ESPRV-IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 + + I D AHNPH AE L +K + + VIG+L DK+ L + + Sbjct: 308 KDGKTYILDGAHNPHGAESLVRSLKLYFNDKPLNLVIGILDDKNREDILRKYTGIFERVI 367 Query: 354 CAPLEGPRGATAEQLLEH----LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 + PR L++ N + + +A + + DTV V GS V + Sbjct: 368 VTCVPSPRMKDMNSLVDTAKKFFKNVEVIEDPLEAIE-----SSEGDTV-VTGSLFLVGY 421 Query: 410 VMEVI 414 V E + Sbjct: 422 VREFL 426 >UniRef50_B8KYD9 Folylpolyglutamate synthase n=1 Tax=gamma proteobacterium NOR51-B RepID=B8KYD9_9GAMM Length = 409 Score = 433 bits (1114), Expect = e-120, Method: Composition-based stats. Identities = 169/409 (41%), Positives = 231/409 (56%), Gaps = 8/409 (1%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + LA WL YLE LH + IDLGLERV VA L + P TVAGTNGKG+ + Sbjct: 5 ADLADWLRYLEGLHPRAIDLGLERVGAVADALELRPPRCSTLTVAGTNGKGSVVAVTAAG 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L AAG+ VGVY+SPHL+ + ER+ + + +P+ A A+F EIE +RGDISL+YFE+ TL+ Sbjct: 65 LRAAGHSVGVYTSPHLIDFNERIVIDDKPVPDEALLAAFEEIERSRGDISLSYFEFATLA 124 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 ALWLF++A +D +LEVGLGGRLDA NI+D D+AV+TSI LDHT+WLGP RE+I EKAG Sbjct: 125 ALWLFRRASVDWQVLEVGLGGRLDAVNILDPDIAVITSIGLDHTEWLGPTREAIAPEKAG 184 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 I R KP +V E + P ++A+ + GA ++ RG +W S G + + Sbjct: 185 IARRGKPVVVLETDPPDSLAESLESMGADIKWRGRDWTMSAEQVHL---CDGGQVALPDI 241 Query: 251 PLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDVAHNPHA 309 + N AL AL +G+ + + D +AS +PGR Q + V+ DVAHN + Sbjct: 242 DGLLSDNIGGALQALSLAGVVID-APMLDELASVRVPGRRQRRHWKGHEVLLDVAHNLES 300 Query: 310 AEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQL 368 E + +++LP R LA+ + DK I L D W+ L E PR + Sbjct: 301 VEAMVASLESLPGGERTLALFAAMADKPIHAMLNACAGCFDRWFLPDLAEQPRAMKPADI 360 Query: 369 LEHLGNGKS--FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + S FD AW A A D ++V GSF TV + +D Sbjct: 361 AALMPEVISTCFDDFDDAWSAVTAALVPGDRLIVFGSFITVGAALARLD 409 >UniRef50_Q9K8G9 Folyl-polyglutamate synthetase n=1 Tax=Bacillus halodurans RepID=Q9K8G9_BACHD Length = 430 Score = 432 bits (1111), Expect = e-119, Method: Composition-based stats. Identities = 121/423 (28%), Positives = 195/423 (46%), Gaps = 22/423 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + ++ + I GL+R+ + +LG + V + GTNGKG+T + +L AGY Sbjct: 8 IEWIHSFLPFGIKPGLQRIEWMLEKLGHPEKELNVVHIGGTNGKGSTVSFMRCMLTEAGY 67 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYGTLS 130 VG ++SP++ + ER+ +G+ + S I ++ S T FE T+ Sbjct: 68 NVGTFTSPYIEHFRERIAYKGEPISSEELVRSCLNIIDVVEELKRTDLGSPTEFEVITVI 127 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A F + D+V+LEVGLGGRLD+TNIV ++++TSI DH + LG ESI EKAG Sbjct: 128 AFDFFARVNPDIVLLEVGLGGRLDSTNIVTPLLSIITSIGHDHMNVLGGTLESIAYEKAG 187 Query: 191 IFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWN-----YSVTDHDWAFSDAHG 243 I + + PAI V +PE I D A + A L G +++ ++ +++ G Sbjct: 188 IIKPDIPAIVHVKQPEAFRVIQDKANKVKAPLFAYGTDFHSLPKSVTMDKQFFSYQSQSG 247 Query: 244 ---TLENLPLPLVPQPNAATALAALRASG----LEVSENAIRDGIASAILPGRFQIVSES 296 +LE + NA+ A+ A+ E+S + I GI + GRF+ +SE+ Sbjct: 248 LTLSLETVMKGHHQIENASMAIQAIEQLRSMKHYELSNDHIVRGIRNTTWIGRFEKISEA 307 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P D AHN + L + + V+ + +K++ LA + + Sbjct: 308 PLTFVDGAHNEEGMKALAELLALHFPTYKYRFVMAVTKEKEMKALLAPYVDLPASFTFTT 367 Query: 357 LEGPRGATAEQLLEHLG--NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 E R AEQL E N A KA + V++CGS + ++ V + Sbjct: 368 FEFERAQKAEQLYEQAPVYNKSICADWKVAIRRERESCKANEMVIICGSLYFISKVRAFL 427 Query: 415 DAR 417 R Sbjct: 428 LER 430 >UniRef50_C9RB31 FolC bifunctional protein n=1 Tax=Ammonifex degensii KC4 RepID=C9RB31_AMMDK Length = 426 Score = 432 bits (1111), Expect = e-119, Method: Composition-based stats. Identities = 136/419 (32%), Positives = 203/419 (48%), Gaps = 21/419 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + L+Y++ + + I GLER+ + RLG V GTNGKG+ L SIL Sbjct: 1 MREALAYIQQVAAVGIKPGLERIEALLERLGNPHRRLRFLHVGGTNGKGSVTAFLSSILR 60 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA-----RGDISLTYFEYG 127 AAGY+VG ++SPHL Y ER R+ G+ + E E+ + I LT FE Sbjct: 61 AAGYRVGTFTSPHLRSYLERFRLNGRPIREREFVWLVNELYPHLEALRQEGIRLTEFEIH 120 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T A LF +A+++V ++EVGLGGR DATN+V ++AV+T++A+DHTD+LG D SI RE Sbjct: 121 TALAFLLFARARVEVAVVEVGLGGRWDATNVVLPELAVITNVAVDHTDYLGSDITSIARE 180 Query: 188 KAGIFRSEKPAIVGEP-EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWA-----FSDA 241 KAGI ++ P + G E + +VA+EKGA L +G ++++ +D Sbjct: 181 KAGIIKAGVPVVTGATGEALRVVEEVAREKGAPLYVQGRDFSFREKANDLTGQVIEVEGW 240 Query: 242 HGTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSE 295 G L L L+ + + A L G ++ + AI+ G+ PGR +IV Sbjct: 241 WGKTPPLRLNLLGRHQQSNAALAVAAARLLEERGWQIDKGAIKVGLYRTRWPGRLEIVFS 300 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 P +I D AHNP L + GR L V+GM DK + + Sbjct: 301 QPTLILDGAHNPAGTAALREALDYYFPRGRRLLVLGMCDDKAREEMVKIIVPGASLVVVT 360 Query: 356 PLEGPRGATAEQLLE----HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 GPR ++ + + +A A+ A+ ED V+V GS + V + Sbjct: 361 RPPGPRSEDWRRVADWARSLCPQVYLVEEPQEALGQALRQARPEDLVVVTGSLYLVGAL 419 >UniRef50_Q1N6P7 Folylpolyglutamate synthetase n=1 Tax=Bermanella marisrubri RepID=Q1N6P7_9GAMM Length = 422 Score = 432 bits (1111), Expect = e-119, Method: Composition-based stats. Identities = 181/422 (42%), Positives = 251/422 (59%), Gaps = 18/422 (4%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + L WL YLE+ H K IDLGL+RV VA RL ++KPA +V VAGTNGKGTT T Sbjct: 2 SRNLDQWLQYLESAHPKDIDLGLDRVRAVAERLDLIKPAKYVVLVAGTNGKGTTVATCGE 61 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 + +G+ VGV++SPH+ +Y ERV + G+++ ++ SF IES RGDISLTYFE L Sbjct: 62 LFRQSGFSVGVFTSPHITKYNERVSINGKQVSDAQLIDSFEAIESKRGDISLTYFEVSAL 121 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 SAL+LFKQA ++ +LE+GLGGRLDA N+VD DV++VTSI LDH DWLG + IG EKA Sbjct: 122 SALYLFKQANVEAAVLEIGLGGRLDAVNLVDPDVSIVTSIGLDHQDWLGDTLDKIGYEKA 181 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH---DWAFSDAHGT-- 244 G++R KPAI G+ PS + A E A L + ++++ + + DW +A G Sbjct: 182 GVYRQSKPAICGQVNPPSGLLAHANEIDAKLLIKHQDFHHQLNEQGGFDWFGVNASGERI 241 Query: 245 -LENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIV------SESP 297 +LPLP VP NA TAL A+ +E + +R + + + GR Q +S Sbjct: 242 VFNDLPLPKVPIENACTALQAMMMLPIEWAIEDVRLALQNVFVEGRLQAFCYQGSSGQSV 301 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 + DV HNP AAE+L + GRV AV+ ML DK+ + LK VD W A L Sbjct: 302 SGMLDVGHNPQAAEFLLQYIPE--TKGRVFAVLAMLQDKNPNDVVTALKDRVDQWCFAGL 359 Query: 358 EGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 +G RG TA++L+ + + + F SV+QA + M + +D V+V GSF TV+ Sbjct: 360 QGYRGQTAQELMSRIDHLPHGSRDFHSVSQAMECVMEEVTCDDYVVVLGSFLTVSAAKSW 419 Query: 414 ID 415 ++ Sbjct: 420 LE 421 >UniRef50_A8FFU4 Tetrahydrofolate synthase n=88 Tax=Bacillaceae RepID=A8FFU4_BACP2 Length = 434 Score = 431 bits (1110), Expect = e-119, Method: Composition-based stats. Identities = 117/428 (27%), Positives = 192/428 (44%), Gaps = 24/428 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + + ++ + + + GLER+ + +L + VAGTNGKG+T S+ Sbjct: 5 TTYHEAIEWIHSRLAFGVKPGLERMKWLMNKLSHPEQRIKAVHVAGTNGKGSTIAFTRSV 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LTYF 124 L AAGY VG ++SP ++ + ER+ V G + + + +I+ ++ T F Sbjct: 65 LQAAGYSVGTFTSPFILTFNERISVNGAPIQDEEWLSLVNKIKPFVDELDQTELGAATEF 124 Query: 125 EYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 E T A F Q+D V+LE GLGGRLD+TN+ + +TSI DH LG E Sbjct: 125 EIITACAFAYFADVQQVDFVLLETGLGGRLDSTNVAAPILTAITSIGHDHMAILGDTLEQ 184 Query: 184 IGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYS-----VTDHDW 236 I EKAGI + P I +PE + I ++A+EK A +S T + Sbjct: 185 IASEKAGIIKVGIPMITAVHQPEALAVIQNIAKEKKAECISLQETCTFSHQQPTETGEQF 244 Query: 237 AFSDAHGTLENLPLPLV---PQPNAATA---LAALRASG-LEVSENAIRDGIASAILPGR 289 + + L L+ + NA+ A + L G + V+E + +GI A+ GR Sbjct: 245 TLNTSKRQYPQLETGLIGTHQRQNASLAVLLIEWLEQEGYISVTEEQVYEGIRHAVWAGR 304 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 F+ V + P V D AHN + L ++A + +V L DK + L++V Sbjct: 305 FEKVKDHPPVYLDGAHNEEGIDRLIETVQAHFSSKQVHICFSALKDKPYKQMIQKLEAVS 364 Query: 350 DDWYCAPLEGPRGATAEQLLEHLG-NGKSFDSVAQAWDAAMADAKAED--TVLVCGSFHT 406 + + PR +AE+L KS+D +A + + +LV GS + Sbjct: 365 SSIHFVSFDFPRAESAEKLYACSQLEAKSYDDDPRAVLEWIQKKSDDPSAVILVTGSLYF 424 Query: 407 VAHVMEVI 414 ++ + + Sbjct: 425 ISDIRNRM 432 >UniRef50_Q8K9X3 Dihydrofolate synthase n=1 Tax=Buchnera aphidicola (Schizaphis graminum) RepID=FOLC_BUCAP Length = 418 Score = 431 bits (1110), Expect = e-119, Method: Composition-based stats. Identities = 186/409 (45%), Positives = 267/409 (65%), Gaps = 4/409 (0%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 + W+ YLE K L + L+A +LG+L F FTV GTNGKGTTC LE +L Sbjct: 7 TFSMWMKYLEKFDKKDRK-NLFELKLIAKKLGLLNLKSFFFTVGGTNGKGTTCAMLEKLL 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 + +GY+VG+Y+SPHL+ Y+ER++V G L E H SF I++ +G++SLTYFE+ TLSA Sbjct: 66 LDSGYQVGLYTSPHLINYSERIKVNGLYLSEKDHIFSFLIIDAEKGNVSLTYFEFITLSA 125 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 L+LF Q LD++ILEVGLGGRLDATNI+D+D++V+T+I +DHT LG DR SIGREK+GI Sbjct: 126 LFLFSQYSLDIIILEVGLGGRLDATNIIDSDLSVITNIGIDHTSCLGTDRISIGREKSGI 185 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-WAFSDAHGTLENLPL 250 FR K A++GE +P ++ ++A+EK +L++ V+W ++ T D W F ++ L NLP+ Sbjct: 186 FRKGKIAVIGEKNIPISVDEIAKEKKTILKKIDVDWFWTRTKIDSWNFIHSNIELYNLPV 245 Query: 251 PLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 +P N A ALA+L SGLEV+ ++ I+ L GRFQ V SPR+I DVAHN HAA Sbjct: 246 SRIPLSNTAIALASLFYSGLEVNLKKLKSSISKVQLSGRFQTVFNSPRIILDVAHNVHAA 305 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 YL+ ++ + G++ AV G+L DKD+AG + L+ ++ WY L+ R A+ L + Sbjct: 306 LYLSEKIDEIDTEGQIYAVFGILKDKDVAGVVQVLQKKINYWYVVNLKTNRSASINYLKK 365 Query: 371 HLG--NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 L N F+++ ++W A +D +LV GSF TV+ M + D R Sbjct: 366 KLSLNNALFFNNINESWQAIKKVITKKDIILVFGSFFTVSEFMSIKDRR 414 >UniRef50_Q8D2P3 FolC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2P3_WIGBR Length = 428 Score = 431 bits (1110), Expect = e-119, Method: Composition-based stats. Identities = 171/414 (41%), Positives = 255/414 (61%), Gaps = 9/414 (2%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P S + W +Y+ LH K IDL L+RV A RL +LKPAP V GTNGKG+TCR Sbjct: 7 PNTHSSIKDWTNYISKLHYKEIDLRLDRVYYFAKRLNLLKPAPITIVVGGTNGKGSTCRF 66 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 LE + + + KVGVYSSPHL+ Y ER+R+ G E+ + + I S++YFE+ Sbjct: 67 LELMFIYSNIKVGVYSSPHLINYNERIRLHGNEVSDEECINAMNFINKIIKKTSISYFEF 126 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 TL AL +FK +LDVVILEVGLGGRLDATN+VD D++VVT++++DHT++LG + I + Sbjct: 127 STLVALLIFKSKKLDVVILEVGLGGRLDATNVVDIDISVVTNVSIDHTEFLGKNCSEIAK 186 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 EK+GIFR +K +I G ++ ++ V W Y W +S+ + Sbjct: 187 EKSGIFRYKKLSIFGGFNNLLNFKSASEYYKSIPYFLNVHWFYKKNKKYWMWSNKTNNIF 246 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 LP P++ NAATALA +++ + +I G+ +A LPGRFQI+++ P +I DVAHN Sbjct: 247 -LPYPILNIENAATALAVIKSLPFTIPYQSIFKGLKTATLPGRFQIINKKPFIILDVAHN 305 Query: 307 PHAAEYLTGRMKALPKNGRVL-AVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGAT 364 P +A++L ++K + KN ++ A+IGML DKDI TL + ++D W CA L E PRGA+ Sbjct: 306 PSSAKHLAKKIKRIKKNFSIIYAIIGMLSDKDIKNTLKYFIKIIDIWNCASLSEFPRGAS 365 Query: 365 AEQL------LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 E++ + N K+F +V A+ + A +D +L+ GSF+T++++++ Sbjct: 366 CEEISIFLNKNKEKNNVKNFKNVISAFKYVINIATKKDCILIFGSFYTISYILK 419 >UniRef50_B2V618 FolC bifunctional protein n=3 Tax=Sulfurihydrogenibium RepID=B2V618_SULSY Length = 413 Score = 431 bits (1108), Expect = e-119, Method: Composition-based stats. Identities = 110/401 (27%), Positives = 192/401 (47%), Gaps = 10/401 (2%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 L + I+ GLER+ L + VAGTNGKG+T LES+L GYK G Sbjct: 7 LFQKKAFNIEPGLERIRSALKELNNPEKNFKSILVAGTNGKGSTSAYLESLLRHYGYKTG 66 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQ 139 +++SPHL+R ER ++ +E+ + E++ +LTYFE TL A F + Sbjct: 67 LFTSPHLIRENERWQIDRKEIDDKKLQNYINELKPIIEKYNLTYFEACTLLAFKYFSDKK 126 Query: 140 LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI 199 +D+ ++EVGLGGR D+TN+++ + +V+T+++ DH LG I EK GI R +KPA+ Sbjct: 127 VDIAVVEVGLGGRWDSTNVLEPETSVITNVSFDHMHMLGNTLLDIAYEKTGITRQDKPAV 186 Query: 200 VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-HDWAFSDAHGTLENLPLPLVPQPNA 258 +G + P I + + K + +++ D + + + ENL + ++ + Sbjct: 187 IGRNQ-PEIIHWLKERKIKEYYIKDIDYFVKEIDFNKYNYKFKEHIFENLEISMLGKRQI 245 Query: 259 ATA-------LAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAE 311 + L L + V EN IR + + GR +I+S++P +I D AHN Sbjct: 246 ENSSLALTTFLLFLDKNNQPVVENIIRKALYNTKWKGRMEIISKNPFIIIDGAHNEEGLI 305 Query: 312 YLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEH 371 +K + N ++ + + DKD + +K D + + R TAE ++ Sbjct: 306 KTFQEIKEIFPNKKIFTIFSFMKDKDTEKMINIIKQNSDFYIATVMPFSRAMTAED-FKN 364 Query: 372 LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 LG ++ +A + +L+ GS + + +++ Sbjct: 365 LGIENVKENHLEAVKELKNSVDKDTIILITGSLYLIGEILK 405 >UniRef50_A7VV81 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VV81_9CLOT Length = 432 Score = 431 bits (1108), Expect = e-119, Method: Composition-based stats. Identities = 123/413 (29%), Positives = 196/413 (47%), Gaps = 18/413 (4%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 + +L + GLER+ + R+G + VAGTNGKG+ C L S+L AGY+ G Sbjct: 10 INSLLRFGMKPGLERIQALLDRMGNPQKQLKFVHVAGTNGKGSACALLSSVLREAGYRTG 69 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEI-----ESARGDISLTYFEYGTLSALWL 134 +++SP++ + ER ++ G+E+PE + E A +T FE T A Sbjct: 70 LFTSPYITDFRERFQINGEEIPEETLARILGRLMPMVEEMAERGEVITEFELITALAFQW 129 Query: 135 FKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F + + DVV+LEVGLGGR DATN++D AV+ SI+LDHT LG E I EK GI + Sbjct: 130 FYEEKCDVVVLEVGLGGRFDATNVIDTPLAAVIMSISLDHTAILGDTVEQIAFEKCGIVK 189 Query: 194 SEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN--LPLP 251 ++ + VA R + SV + + + + LP Sbjct: 190 EGGDVVLYPDQEEGVYGVVAHAVQNHNGRLVLPSPSSVREVSSSIEGTVASYRDEEYQLP 249 Query: 252 LVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 + AL L+ G +S A++ G+A A +P R +++ SP VI D AH Sbjct: 250 FLGAHQLKNAAAAFAALELLKEKGYRISREAMQAGVAKAYIPARMEVLGRSPLVILDGAH 309 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATA 365 NP AA L ++ + +++ V+GML DKD +L L S+ A + PR A Sbjct: 310 NPGAARVLAQALEKYLPHRKIIGVMGMLKDKDSRSSLRSLASLFQALITASPKNPRALPA 369 Query: 366 EQLL----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 +L E+ + + +++A A A + +++CGS + + ++ Sbjct: 370 AELADRAREYCSQVFAEEDLSKAICLARKLAGEDGAIVICGSLYLAGEIRPLL 422 >UniRef50_Q1PZI3 Similar to multifunctional folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZI3_9BACT Length = 464 Score = 430 bits (1107), Expect = e-119, Method: Composition-based stats. Identities = 123/446 (27%), Positives = 198/446 (44%), Gaps = 32/446 (7%) Query: 1 MIIKRTPQAASPLASWLSY--LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTN 58 + ++ +A + L + L Y L + T L+R+ + ++G + GT Sbjct: 11 LCLRSYEEACAFLNTSLDYEKLISYQYNTSTFNLDRMVRLLEQVGNPHREFSSLHITGTK 70 Query: 59 GKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASF-------AE 111 GKG+T L ++L AGYK G+++SPHL ER+++ ++PE TA+ Sbjct: 71 GKGSTAIMLSTVLQRAGYKTGLFTSPHLTNLKERIQLNHTKIPEEDFTAALNVLVPDIQR 130 Query: 112 IESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIAL 171 + + S T+FE T FK+ Q ++ +LEVG+GGRLDATN+V V+V+T+I L Sbjct: 131 LRNTTPAESPTFFETLTAICFLYFKEKQAEMAVLEVGMGGRLDATNVVLPLVSVITNIGL 190 Query: 172 DHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEW-- 227 DH + LG I EKAGI + P I +PE S I +V EKGA L G + Sbjct: 191 DHVNILGNTIPRIAYEKAGIIKKGIPVISAAEKPEALSVIKEVCMEKGAPLYLLGKDIRI 250 Query: 228 -------NYSVTDHDWAFSDAHGTLENLPLPLVPQPNAAT------ALAALRASG-LEVS 273 N + G NL +PL+ A AL LR G + + Sbjct: 251 DDAQPYTNKNSRGLLCNIKTWQGVYGNLFIPLMGIHQAKNCAMALGALDVLREHGKISID 310 Query: 274 ENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGML 333 IR+ PGR +++ E+P ++ D AH + L + +++ ++G Sbjct: 311 NETIREAFTHVRCPGRIEVLGETPLIVLDFAHTVESMAALRETLFEHFTFNKLVVILGFS 370 Query: 334 HDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAA 388 DKDI L + +D + R E+L + + + +S A AA Sbjct: 371 QDKDIDNILREIVPCANDIFVTKSTNSRAVPPEELAKKIKAVYGKRAEICNSARDAVIAA 430 Query: 389 MADAKAEDTVLVCGSFHTVAHVMEVI 414 A +D + + GS + V + + Sbjct: 431 QHAASPDDLLCITGSAYIAGEVRQEL 456 >UniRef50_UPI0000E0E8A2 FolC bifunctional protein n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=UPI0000E0E8A2 Length = 425 Score = 430 bits (1106), Expect = e-119, Method: Composition-based stats. Identities = 180/423 (42%), Positives = 244/423 (57%), Gaps = 16/423 (3%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 T A + L WL++LE++H ID+GL+RV V RL + V TVAGTNGKGTTC Sbjct: 2 TLTADASLMEWLTHLESIHPVGIDMGLDRVQAVYQRLNLDWSGVTVITVAGTNGKGTTCA 61 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 +E+ + GY+VGVYSSPH+ Y ERVR+ Q L ++AHT +FA IE+ARG+ISLTYFE Sbjct: 62 FIEAAAIQCGYEVGVYSSPHINTYNERVRINQQLLDDTAHTQAFAAIEAARGNISLTYFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 +GTL+ LWL Q LDV +LEVGLGGRLDA N+VD D+AV+TSI LDH +LG R I Sbjct: 122 FGTLAGLWLLHQQALDVAVLEVGLGGRLDAINVVDPDIAVITSIGLDHQAFLGDTRALIA 181 Query: 186 REKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 +EKAGI R+ KP I+GEPE P T+ + A Q ++ Y + + + F L Sbjct: 182 QEKAGIMRAGKPVIIGEPEPPHTLREAVVSYAADAQWVSQDFAYHIEHNLFHFKMGSTQL 241 Query: 246 ENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIV------SESPRV 299 +LPLP +P PNAATA+A + VS + A L GR ++ SE+P + Sbjct: 242 -SLPLPHIPFPNAATAMAVVHQLAWPVSASQWAYCAAHTRLNGRLTVLTEHAFGSEAPVI 300 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 + D AHN A+EYL + L RV AV G++ DKD AG A L +V WY ++ Sbjct: 301 MLDAAHNIQASEYLATHIAHLAP-RRVFAVCGIMQDKDWAGVCAPLVPLVSHWYPCDVQI 359 Query: 360 PRGATAEQLLEHLGN--------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 R A + L N + ++ + A+ A +D VL+ GSF T++ Sbjct: 360 ERAAKGSDIAACLVNSLAINKTQVTAVNTPYEGVVNAIKTATNQDLVLIFGSFFTLSDFY 419 Query: 412 EVI 414 + Sbjct: 420 AQL 422 >UniRef50_B5YJI6 Folylpolyglutamate synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YJI6_THEYD Length = 438 Score = 430 bits (1106), Expect = e-119, Method: Composition-based stats. Identities = 127/425 (29%), Positives = 214/425 (50%), Gaps = 23/425 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 ++ L + I LGL RV V +LG + +AGTNGKG+ + + ++ Sbjct: 7 YKELINELYKKRTNGIKLGLNRVISVLEKLGNPHHSFKSIHIAGTNGKGSVSKIIYCLIR 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 A G VG+++SPHL R+TER+ V E+ E +I+ + LT+FEY T+ AL Sbjct: 67 AQGLSVGLFTSPHLTRFTERIIVNDIEISEEEVEHLIEKIKPFSDE--LTFFEYVTVMAL 124 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 FK+ ++ ++E G+GGRLDATN+V+ ++V+T+I LDH ++LG D SI +EKAGI Sbjct: 125 QYFKEKGIEYAVIETGMGGRLDATNVVNPLISVITNIGLDHQEFLGADLASIAKEKAGII 184 Query: 193 RSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTD----------HDWAFSD 240 ++ P + E+ I A+E + L ++ + + ++F Sbjct: 185 KNGIPVVSSSQKKEVEKVIIKKAEEMESPLFIYDRDFIGVLKSMSLEGIVFDFYPFSFQP 244 Query: 241 AHGTLE-NLPLPL---VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 + +L+ NL LPL N + AL A +ENAI++G+ + +PGR +I+ + Sbjct: 245 STSSLQSNLFLPLTGFHQLENVSVALKAFINIYPMYNENAIKEGLKNVKIPGRLEIIYDK 304 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P +FD+AHNP AAE L +K L + + + V M+ DK++ + ++ Sbjct: 305 PLAVFDIAHNPDAAEVLIKSLKTLT-DKKPVVVFAMMRDKNVNEFIKCFENYAYKMIFTV 363 Query: 357 LEGPRGATAEQLLEHLGNGK--SFDSVAQAWDAAMADAKAEDTV--LVCGSFHTVAHVME 412 R T ++LL+ L + K +A+ A++ K + L GS + V + E Sbjct: 364 PNYERALTYKELLKRLNDKKIDFVPEPLEAFRNAISLCKNNSDIYVLCTGSAYLVGEIKE 423 Query: 413 VIDAR 417 + + Sbjct: 424 RLGEK 428 >UniRef50_C9KNY5 Tetrahydrofolate synthase n=2 Tax=Veillonellaceae RepID=C9KNY5_9FIRM Length = 439 Score = 429 bits (1104), Expect = e-118, Method: Composition-based stats. Identities = 121/437 (27%), Positives = 196/437 (44%), Gaps = 25/437 (5%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 + A +SYLE L I LGL R+ + L + + V GTNGKG+ Sbjct: 2 ERRAMNYQEAISYLEGLKIFGIRLGLTRIERLLELLDMPQDRYRTIHVTGTNGKGSVSAM 61 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDIS 120 +E +L +G G YSSPHLV YTER+RV GQ + E I + A G Sbjct: 62 VEGVLRRSGIHTGFYSSPHLVSYTERIRVDGQNISEQDFAEGMTVIRAKIDMMLAEGAEC 121 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 T FE T + F + Q++ ++EVGLGG LD+TN++ +V+V+T++ ++H D LG Sbjct: 122 PTQFEVLTALGFYYFAKCQVEYAVIEVGLGGTLDSTNVITPEVSVITNVTMEHADKLGGT 181 Query: 181 RESIGREKAGIFRSEKPAIVGEP-EMPSTIADVAQEKGALLQRRGVEW-----NYSVTDH 234 +SI KAGI + P + E I VA+EK A + G ++ + Sbjct: 182 LQSIAENKAGIIKEGVPVVTAAKGEPLEVIRAVAEEKNADIFVAGEDFCSQFLSCDGRTQ 241 Query: 235 DWAFSDA-----HGTLENLPLPLVPQPNAATALAALRAS---GLEVSENAIRDGIASAIL 286 F+ H E L + N+A AL +R ++ + + + Sbjct: 242 KLEFTSELLGIDHEPYELHLLGVHQVENSAVALMTIRLLHNIDDRITMKTVTEALRLVSW 301 Query: 287 PGRFQIVS-ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 P RF+ + ++ D AHNP + L + + + ++G+L DKDI L L Sbjct: 302 PARFERLELGQQAIVVDGAHNPAGMKALRESLDEIFPAEERVLLLGILKDKDIDTMLDIL 361 Query: 346 KSVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVC 401 D + R +A LL + + ++F++ +A + A+ A E +++ Sbjct: 362 LRPNDTVVVTVPQSERADSAADLLRRVAPAVQHVEAFENNTEALNRALELANGEKLLVIA 421 Query: 402 GSFHTVAHVMEVIDARR 418 GS + V V +++ R Sbjct: 422 GSLYLVGGVRQMLLKRE 438 >UniRef50_Q02Z16 Folylpolyglutamate synthase n=20 Tax=Bacteria RepID=Q02Z16_LACLS Length = 427 Score = 429 bits (1103), Expect = e-118, Method: Composition-based stats. Identities = 110/426 (25%), Positives = 192/426 (45%), Gaps = 19/426 (4%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 + L ++ + I GL RVS + LG + + + +AGTNGKG+T SI Sbjct: 2 SIEQALEWIHSRLKFNIRPGLNRVSALLELLGNPEESLSMIHIAGTNGKGSTVAFTRSIF 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTYF 124 M AG KV ++SP + + ER+ + Q +P+ I+ + +T F Sbjct: 62 MQAGLKVASFTSPFITTFGERMSINAQPIPDEKLIYYVKMIQPLVEKLDNDAELTGITEF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T A F ++D+ ++EVGLGG LD+TN++ V+ +T+I LDH D LG E I Sbjct: 122 EIITAMAFKYFADEKVDLAVIEVGLGGLLDSTNVIRPVVSGITTIGLDHIDILGSTIEEI 181 Query: 185 GREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDHD-WAFSDA 241 +KAGI ++ P +VG E I +VA++ A + + ++ + +H+ + F + Sbjct: 182 AAQKAGIIKAGIPVVVGNIELKALRVIWEVARKNTARIYQYPYDYRTELKEHEHFDFFAS 241 Query: 242 HGTLENLPLPLVPQPNAATALAALRAS-------GLEVSENAIRDGIASAILPGRFQIVS 294 + +L L+ A A+ + G+ ++E IR GI A P R + + Sbjct: 242 QEAILDLEKSLIGLHQVENAGMAIELALVYANKVGINLNEEIIRAGIREAFWPARMEKLG 301 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD-DWY 353 E+P ++ D AHN HA L + + ++ + + KDI + L++V + Sbjct: 302 ENPLILLDGAHNVHAMNRLLENLGKEFPDKKITIIFSAITTKDIRQMIKMLQTVKNSRLI 361 Query: 354 CAPLEGPRGATAEQLLEHLGNGKS-FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 + P+ + G S A A ++ +L+ GS + + V E Sbjct: 362 LTTFDYPKALDLKDFRYLEDEGVELAPSWELAIVRAQKALNEDELLLITGSLYFSSQVRE 421 Query: 413 VIDARR 418 + + Sbjct: 422 FLKKEK 427 >UniRef50_C5SCQ4 FolC bifunctional protein n=1 Tax=Allochromatium vinosum DSM 180 RepID=C5SCQ4_CHRVI Length = 432 Score = 429 bits (1103), Expect = e-118, Method: Composition-based stats. Identities = 186/417 (44%), Positives = 248/417 (59%), Gaps = 16/417 (3%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF--VFTVAGTNGKGTTCRTLE 68 + L WL + +LH +DLGLERV V ARL + V TV GTNGKG+T +E Sbjct: 11 ATLDDWLDWQSSLHPSRMDLGLERVGAVWARLAPERGRLPCPVITVGGTNGKGSTVAMIE 70 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 S+ +AAGY+ GVY+SPHL RY ERVR+ G + + A SF I+ AR ISLTYFE+GT Sbjct: 71 SMALAAGYRCGVYTSPHLCRYNERVRLDGVPVADEALCDSFERIDRAREGISLTYFEFGT 130 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+AL +F +A+ D+V+LEVGLGGRLDA N++D+DV+VVTSI LDHTDWLG ESI REK Sbjct: 131 LAALDIFARARPDLVVLEVGLGGRLDAVNLIDSDVSVVTSIGLDHTDWLGDSLESIAREK 190 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 AGIFR +PAI+G+ + P T+ A GAL + G E +++ T W ++ G L Sbjct: 191 AGIFRPGRPAIIGQRDAPETLRAEAARIGALALQLGRELDHARTTEGWIWTGPDGQRLAL 250 Query: 249 PLPLV-------PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 P+P + A A+ ALR L V NAIR G+ A LPGRFQ++ + I Sbjct: 251 PIPALRGSFQLDNATAAIAAVQALR-ERLPVPVNAIRAGLQRARLPGRFQVMPGAVTWIL 309 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 DVAHN AAE L ++ GR+ AV+ +L DK+ + ++ V+DWY A E R Sbjct: 310 DVAHNGEAAEALAANLRDFACPGRLRAVLAVLADKNPERLVTPIREYVNDWYLAQSEDAR 369 Query: 362 GATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 EQL L +F VA+A AA+A++ D +L+ GSF TV + Sbjct: 370 ALPVEQLSARLDGLIGANRRGAFGCVAEAIGAALAESAPGDALLIVGSFTTVGQALR 426 >UniRef50_Q3A6L0 Folylpolyglutamate synthetase; dihydrofolate synthetase n=1 Tax=Pelobacter carbinolicus DSM 2380 RepID=Q3A6L0_PELCD Length = 422 Score = 428 bits (1102), Expect = e-118, Method: Composition-based stats. Identities = 137/418 (32%), Positives = 206/418 (49%), Gaps = 13/418 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+YL L I LGL + + ARL + A + VAGTNGKG+ IL Sbjct: 3 YQQSLAYLYGLQRFGIKLGLTNIQTLLARLDHPERAMRIVHVAGTNGKGSVSAATALILQ 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AGY+ G+Y+SPHL +TER+R+ G ++ E + E+ + G + +T+FE+ T AL Sbjct: 63 TAGYRTGLYTSPHLHSFTERIRIDGVQVSEPDMVSLVDEVRAVVGSLPVTFFEFTTAMAL 122 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F+ D +LEVG+GGRLDATN V+++++VVT + DH + LG D +I EKAGI Sbjct: 123 VYFRNRHTDFAVLEVGMGGRLDATNAVESEISVVTPVCCDHAEHLGADLATIAGEKAGII 182 Query: 193 RSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 + + P ++ E P+ + A E A + ++ D + F TL+ L Sbjct: 183 KRQVPVVIAEQHPDAQRVLLTKAAEMLAPVCLWDRDFRIIDHDTHFDFFAPSLTLKGLRP 242 Query: 251 PL---VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 L + N A ALAA LR G+ +SE A+R G+ PGR + + R++ D A Sbjct: 243 GLAGAHQRQNLAVALAACMSLRNRGVALSEEALRYGVEKVQWPGRLEWWRQQRRILLDGA 302 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HN A L + +L +V V+G+ + I L L Y +G Sbjct: 303 HNHGGAVVLARYLASLD-GKKVRWVVGIKGQRCIDDILTPLLPHTAHLYATLPPVDQGIE 361 Query: 365 AEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 ++L+ K++ + A A AA+AD +D VLV GS VA V + + R Sbjct: 362 PDKLVRAARAAGVLAKAYATPADAMTAALADQGEDDVVLVAGSLFLVAAVRDYLMDRE 419 >UniRef50_C2E893 Folylpolyglutamate synthase / dihydrofolate synthase n=1 Tax=Lactobacillus ruminis ATCC 25644 RepID=C2E893_9LACO Length = 437 Score = 427 bits (1100), Expect = e-118, Method: Composition-based stats. Identities = 116/431 (26%), Positives = 200/431 (46%), Gaps = 27/431 (6%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 +S++ T D L ++ +A +G + + V GTNGKG+ L +L Sbjct: 5 SYDEAVSFIHGRRKFTKDPSLVKMRRMAELMGNPQKKLKLIHVTGTNGKGSVTAYLRELL 64 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTYF 124 M+ GY+VG ++SP +VR+ ERV + G+ +P++ I+ I F Sbjct: 65 MSHGYRVGTFTSPFIVRFNERVAINGEMIPDNELVEEVERIKPVIERIDDEFDNDGPKEF 124 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T L F + ++D I+EVG+GG D+TNI+D V+V+T++A+DH + LG + Sbjct: 125 EVLTAIMLDYFVKMEVDYAIIEVGIGGTYDSTNIIDPIVSVITTVAMDHANILGDTIAKV 184 Query: 185 GREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 KAGI + ++P I+G E I A+E+ + + + V++ + + F Sbjct: 185 AENKAGIIKKKRPVIIGKLPKEALEVILSKAKEQDSRIYQPEVDYRARLEEGCDHFWGES 244 Query: 243 GTL----ENLPL------PLVPQPNAATALAAL----RASGLEVSENAIRDGIASAILPG 288 E PL NAA AL A G+++ + + PG Sbjct: 245 FAYEFEEEKWPLQRTGLFGNFQVDNAACALTAFNVLSEIEGIKIDRRKAGEALEKTRWPG 304 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA-WLKS 347 RF+ + E P ++ D AHNP A E + ++ K ++ ++G+L DK+ + LK+ Sbjct: 305 RFEKIQEDPLIVLDGAHNPSAMEEVEKTLETNFKGKKITVILGILADKNSGEMIEVLLKN 364 Query: 348 VVDDWYCAPLEGPRG-ATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 +GPR A+ ++L E+ D +A +AA+ + D +L GS + Sbjct: 365 PKASIILTGFDGPRQVASPKKLHENHPRTIEIDDWKEALEAAL--MQKSDLILASGSLYF 422 Query: 407 VAHVMEVIDAR 417 ++ V + I R Sbjct: 423 ISDVRKYILER 433 >UniRef50_Q2JLQ4 Folylpolyglutamate synthase n=2 Tax=Synechococcus RepID=Q2JLQ4_SYNJB Length = 433 Score = 427 bits (1100), Expect = e-118, Method: Composition-based stats. Identities = 139/423 (32%), Positives = 210/423 (49%), Gaps = 29/423 (6%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 P W ++LE+L +DL LER+ ++ RLG + VAGTNGKG+ C + +L Sbjct: 9 PDWDWPAFLESLGHFGVDLSLERMQVLLQRLGQPQAGIPAIHVAGTNGKGSVCAWVSHVL 68 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-----ARGDISLTYFEY 126 AAGY+VG Y+SPHLV + ER+ + G+ + + + + A++ A + S T FE Sbjct: 69 WAAGYRVGRYTSPHLVDWRERIWLNGEYISANDWSQALAQVRDCLQTYAPDEASPTQFEV 128 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNI-VDADVAVVTSIALDHTDWLGPDRESIG 185 T +A F++ ++DV ++EVGLGGRLDATN ++ V +TSI DH LG I Sbjct: 129 ITAAAWLYFRRQKVDVAVIEVGLGGRLDATNAGIEPVVTAITSIGWDHWQRLGNSLPQIA 188 Query: 186 REKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 EKAGI + PA+ PE+ + I A++ + L+ W G Sbjct: 189 SEKAGILKPGIPAVCAPQTPEVTAVIRAKAEQLRSPLRVVDPLQWSEPQTVHW-----RG 243 Query: 244 TLENLPLPL-VPQPNAATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVS-ESPR 298 L LPL V NAA ALA L+ G +++ A+ G A PGR Q V S + Sbjct: 244 QLLTLPLSGDVQLTNAAVALAVVETLQQQGWRIADAAVEKGFAITRWPGRLQRVQIGSRQ 303 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 ++ D AHN AA+ L + G + +G+L KD+ G L+ L D ++ P+ Sbjct: 304 LLMDGAHNLPAAQALRRYLDEHQP-GPLTWYVGILTTKDVQGILSTLLRPGDCFFALPIA 362 Query: 359 GPRGATAEQLLE-------HLGNGKSFDSVAQAWDAAMADAKA--EDTVLVCGSFHTVAH 409 G G EQL + HL + + ++ A A + K E ++CGS + + Sbjct: 363 GHSGTDPEQLAQLAQTLQPHLASARELPNL-SALRAQLLKPKNLTELPAVICGSLYLLGQ 421 Query: 410 VME 412 VM+ Sbjct: 422 VMQ 424 >UniRef50_Q1D8V1 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Cystobacterineae RepID=Q1D8V1_MYXXD Length = 410 Score = 427 bits (1100), Expect = e-118, Method: Composition-based stats. Identities = 137/395 (34%), Positives = 195/395 (49%), Gaps = 16/395 (4%) Query: 33 ERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTER 92 ERV A LG + VAGTNGKG+TC + L AAG++VG+Y+SPHLVR ER Sbjct: 2 ERVQEALAALGHPERRYPALHVAGTNGKGSTCAMTAASLHAAGHRVGLYTSPHLVRVNER 61 Query: 93 VRVQGQELPESAHTASFAEI---ESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGL 149 +RV +++ ++ E+ + +TYFE+GT+ ALW F Q ++DV +LE GL Sbjct: 62 IRVDSEDISDADFGLRILEVLERYPSAVSSPMTYFEFGTVVALWHFAQVRVDVAVLETGL 121 Query: 150 GGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PEMPS 207 GGRLDAT V +T ++ DH ++LG +I EKAGI + P +V PE Sbjct: 122 GGRLDATTAASPVVTAITPVSFDHMEYLGDTLAAIAGEKAGILKPGVPCVVARQAPEALE 181 Query: 208 TIADVAQEKGALLQRRGVEWN-YSVTDHDWAFSDAHGTLENLPLPL---VPQPNAATALA 263 I A++ GA ++ G ++ D ++ A +L+ L + L + NAA ALA Sbjct: 182 AILRKAEQVGAPVRLEGRDFTGERQPDGGLSYRGATWSLDGLSVALRGPHQRQNAAVALA 241 Query: 264 ---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKAL 320 AL+ G+ A R G+ASA PGR + V + P ++ D AHNP E L +K L Sbjct: 242 CLEALQERGVTAPPEAARAGLASACWPGRLEEVGQQPILLLDGAHNPAGVEVLLASLKDL 301 Query: 321 PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE----QLLEHLGNGK 376 R+ V G++ DKD + L PLE PR E + + Sbjct: 302 YPGRRLHLVFGVVGDKDRGPMMRALLPECASVQLTPLETPRSLAPEAYLAEARALCADVT 361 Query: 377 SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 ++ A AA A A D VL GS V + Sbjct: 362 AWPDADAALAAARKRAAANDLVLCTGSLFLVGMMK 396 >UniRef50_Q89AT2 Dihydrofolate synthase n=4 Tax=Buchnera aphidicola RepID=FOLC_BUCBP Length = 426 Score = 427 bits (1100), Expect = e-118, Method: Composition-based stats. Identities = 181/417 (43%), Positives = 264/417 (63%), Gaps = 4/417 (0%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 MI K+ ++ S L WL YL++ ID L RV VA +LGVLK FVF V GTNGK Sbjct: 1 MINKKLARSFS-LYEWLYYLDHFMLDNIDPTLNRVFYVAKKLGVLKSKAFVFIVGGTNGK 59 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 G+TC LE++L+ +GY+VG+Y+SPHL+RYTERVR+ G EL H ++F +++ + D+ Sbjct: 60 GSTCHVLENLLLNSGYRVGLYTSPHLMRYTERVRINGFELEHLYHISAFNDVKYFQNDVL 119 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 LT FE+ TLSAL LFK LD++ILEVGLGGRLDATNI+ ADV+V+T+I +DH+ LG + Sbjct: 120 LTRFEFITLSALILFKSYNLDIIILEVGLGGRLDATNILSADVSVITNIDIDHSKILGVN 179 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD 240 R SI EK+GIFR K AIV + P +A++K L+ ++W Y + +W+F Sbjct: 180 RSSISVEKSGIFRKNKIAIVADNNFPKVAQYLAKKKKVRLRIVNIDWIYKKIEFEWSFCS 239 Query: 241 AHGTLENLPLP-LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 + T +LPLP V + ATAL+A+ SG+++++ R I+ L GRF+ +S +P + Sbjct: 240 SKITWLHLPLPRNVSLDSVATALSAVSESGIKINQKVFRSCISEITLCGRFETISYNPII 299 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 I DVAHNPH+A YL +M + KNG + AV+G+L +K+I ++ L +VD WYC L Sbjct: 300 ILDVAHNPHSARYLFKKMSSFKKNGNIFAVVGILKEKNIKDIVSPLIPIVDYWYCITLLT 359 Query: 360 PRGATAEQLLEHLGNG--KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 R AT+ +++++L N + ++ A + D VL+ GSF TV + + Sbjct: 360 HRSATSSEIIKYLPNHNSQISKNMTVALEKIFDKVTNNDIVLIFGSFITVCEANKFL 416 >UniRef50_B0S2B5 Folylpolyglutamate synthase n=2 Tax=Finegoldia magna RepID=B0S2B5_FINM2 Length = 415 Score = 426 bits (1097), Expect = e-118, Method: Composition-based stats. Identities = 114/412 (27%), Positives = 206/412 (50%), Gaps = 19/412 (4%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 YL+ + LGL+R+ LG + + + VAGTNGKG+T + L GYK Sbjct: 8 EYLDKIGRDGYKLGLDRMQKTLKILGNPEKSFKIIHVAGTNGKGSTSTFIYQTLKEHGYK 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES--ARGDISLTYFEYGTLSALWLF 135 G+++SPH++ + +R+++ +E+ E F I+ + DI ++ FE+ TL A++ F Sbjct: 68 TGLFTSPHIINFYDRIKID-KEISEEDFMRIFEIIKDTIEKNDIKVSTFEFITLCAIYYF 126 Query: 136 KQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIFRS 194 + + + V+LEVG+GGRLDATN D ++V+T I LDH ++LG E I EKA I + Sbjct: 127 AEQKCEYVVLEVGMGGRLDATNATDETLLSVITKIGLDHQEYLGNTLEEIAYEKACIMKQ 186 Query: 195 EKPAIVGEPE--MPSTIADVAQEKGALLQRRGVE----WNYSVTDHDWAFSDAHGTLENL 248 +V + + + +VA+E+ L + + T + + + + H +E Sbjct: 187 NGRCVVYDQQESVLDVFREVAEERNNKLYICDFDEAKNIEINATHNSFDWKNLH--IETR 244 Query: 249 PLPLVPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 + NA AL A+ L++S+ I +G +A +P RF ++ +P VI+D HN Sbjct: 245 LVGRYQLFNAQLALTAIDVLRDELDLSDEDIINGFKNAYIPARFDVIRHNPTVIYDGGHN 304 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 + L ++++ + +++ V G+L DKD + + + + PR AE Sbjct: 305 ADGVKALKSSIESVFGDKKIVFVYGVLKDKDYNDEIKLIHENAKAFVTFTPDSPRALKAE 364 Query: 367 QLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 L + + N + +V A D A+ K +D +++ G+ ++ E + Sbjct: 365 DLKKQIEVYSDNVVAKSNVNDAVDYAIEHFK-DDVIIIFGTLYSAEQAYEHL 415 >UniRef50_Q01UR3 FolC bifunctional protein n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q01UR3_SOLUE Length = 422 Score = 426 bits (1096), Expect = e-118, Method: Composition-based stats. Identities = 133/406 (32%), Positives = 190/406 (46%), Gaps = 20/406 (4%) Query: 26 KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPH 85 KT LGLER++ V LG + VAGTNGKG+TC +ES L A+G G+++SPH Sbjct: 18 KTAKLGLERIARVLEALGNPHRRTRIVHVAGTNGKGSTCAMIESGLRASGRSTGLFTSPH 77 Query: 86 LVRYTERVRVQGQELPESAHTASFAEIESARG--------DISLTYFEYGTLSALWLFKQ 137 L TER+R+ G + +A+F + +A D+ TYFE T A +F + Sbjct: 78 LAEPTERIRINGVPVSAERFSAAFDRVHAAVEQLLAVNAIDLHTTYFETVTAMAFLIFAE 137 Query: 138 AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKP 197 +D+V+LEVGLGGRLDATN+V ++ V+T + DH +LG + I EKAGI ++ P Sbjct: 138 EAVDIVVLEVGLGGRLDATNVVLPELCVITPVDFDHEAFLGRSLQEIAGEKAGILKAGVP 197 Query: 198 AIVGEP--EMPSTIADVAQEKGALLQRRGV----EWNYSVTDHDWAFSDAHGTLENLPLP 251 A+ E + + A + + R + + S PL Sbjct: 198 AVFARQRAEASAVLDQRAAQLSIPIARTVAWPVDDLVLDSRGSRFLLSGERDLHIACPLA 257 Query: 252 L-VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 NAATA AL G VS+++I GIA PGR + VSE P +I D AHNP A Sbjct: 258 GEHQVENAATAAIALTRLG--VSDHSIETGIAQTRWPGRLERVSEHPEIILDGAHNPAGA 315 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 L ++ RV + G + DK I L + R E + E Sbjct: 316 RALAAYIERFYAGRRVRLIYGAMRDKAIDEIAGILFPLAHQVILTAPRQARALAPEAIRE 375 Query: 371 HL--GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 + + +AQA A + DA + D V + GS VA ++ Sbjct: 376 IADHPDVQVAPDLAQAI-ALLCDAASNDAVFITGSLFLVAEARALL 420 >UniRef50_Q31HH1 FolC bifunctional folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Thiomicrospira crunogena XCL-2 RepID=Q31HH1_THICR Length = 425 Score = 426 bits (1096), Expect = e-118, Method: Composition-based stats. Identities = 167/419 (39%), Positives = 241/419 (57%), Gaps = 16/419 (3%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P + L W+ +L +LH+ IDLG++RV VA + + P+P V +VAGTNGKG++ Sbjct: 3 PTDTTSLTEWIDWLVSLHADEIDLGIDRVKSVAEAMNLASPSPVVISVAGTNGKGSSVAM 62 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 L SI A+GY+VGVY+SPHL+ + ER+RVQGQ + +FA IE+ARG LTYFE+ Sbjct: 63 LSSIYEASGYQVGVYTSPHLLHFNERIRVQGQLADDQQIVQAFAAIEAARGQTKLTYFEF 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 TL+ALW+F Q LDV++LEVGLGGRLDA N+VDAD +++T+I +DH DWLG DR I Sbjct: 123 STLAALWVFAQHALDVILLEVGLGGRLDAVNLVDADASLITAIGVDHEDWLGSDRNQIAV 182 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA--HGT 244 EKAGI RS KP I + ++P T+ A + L+R E+ Y D W+F D+ Sbjct: 183 EKAGIMRSGKPTICSDNDIPETLISYASQHNVPLKRLAKEFFYQKNDQAWSFLDSEHKPI 242 Query: 245 LENLPLPLV----PQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVS-ESP 297 ++L LP + NAA +A + S L VS + + G++ PGR Q + + Sbjct: 243 YQDLALPALSGDFQIQNAAGVVALVETLQSDLPVSFDQLSQGLSDVTHPGRLQKIQFDHQ 302 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 + DVAHNP AA+ L +K A+ +L DKD+ + +K + W A L Sbjct: 303 NWLIDVAHNPQAAQVLAHYLKQASIQAN--AIFSVLQDKDVVPMVEAIKPYIKKWSIADL 360 Query: 358 EGPRGATAEQLLE-HLGNGKSFDSVAQAWDAAMADAKAEDT----VLVCGSFHTVAHVM 411 PR + ++L L +G +++ + + + A A T VLV GSF TV+ + Sbjct: 361 AVPRALSVDKLERVLLQSGVPSENIVKCSNISEAVAHNRQTSGNDVLVWGSFFTVSQTL 419 >UniRef50_UPI0000E88026 folylpolyglutamate synthetase n=1 Tax=Methylophilales bacterium HTCC2181 RepID=UPI0000E88026 Length = 423 Score = 426 bits (1095), Expect = e-117, Method: Composition-based stats. Identities = 145/411 (35%), Positives = 221/411 (53%), Gaps = 13/411 (3%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L +WL Y+E LH I+L LERV V L + P + V GTNGKG+ C +ESI Sbjct: 9 DSLEAWLDYIEKLHPSEIELTLERVREV-KDLANISPDFPIILVGGTNGKGSVCAFIESI 67 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L A+ K+G Y+SPHL+R+ ER+R+ E+ + A + IE +R DI LTYFE TL+ Sbjct: 68 LHASDLKIGCYTSPHLLRFNERIRINKHEVDDKAIVNALDHIERSRRDIPLTYFEITTLA 127 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ +D+ ILEVGLGGRLDA NI ++++T+++LDH +LG + IG EK+G Sbjct: 128 AVKCMNDEAVDIAILEVGLGGRLDAVNIFSPTISLITTVSLDHQAYLGDSVDKIGFEKSG 187 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 IFR PAI+ ++ A + A L G ++N + D +++ + +LPL Sbjct: 188 IFRRNIPAIINHKNPIPSMISAANKINANLSLLGNDYNLVIHDKSLSYTSNDLSYSDLPL 247 Query: 251 PLV----PQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 P + N A AL + + +S AI+ GI+ A + GRF+++ +P V+ DVA Sbjct: 248 PQIKGNHQIINLAGALRCIELLNSTIPISIKAIKKGISDASIRGRFEVLLNNPLVVVDVA 307 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNP +A L +G A+ + DKD+ + +V+D WY A L R + Sbjct: 308 HNPESANNLANNFMDAKLDGITTAIFSVFEDKDVLSIIQPFINVIDKWYIAELSSERALS 367 Query: 365 AEQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 E + E L + + F +V A+ A+ +A D +L+ GSF ++ Sbjct: 368 CEGIEEALKSVMPTVTVEKFPTVRHAYKEALKNAHDNDNILMFGSFLVISE 418 >UniRef50_D1BNH4 FolC bifunctional protein n=3 Tax=Veillonella RepID=D1BNH4_VEIPT Length = 435 Score = 426 bits (1095), Expect = e-117, Method: Composition-based stats. Identities = 124/428 (28%), Positives = 188/428 (43%), Gaps = 25/428 (5%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L+YLE S I GLER++ + LG + + V GTNGKG+ + L Sbjct: 2 TYQEALAYLEQASSFGIKPGLERITALMDVLGNPQEDYKIVHVTGTNGKGSVTSYISYAL 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFE 125 +G +VG ++SPHL YTER+++ + E A + ++ A I + T FE Sbjct: 62 FTSGLRVGRFTSPHLQSYTERIQINDGNITEEAFGELISRVKGAVDTIVSNGIEAPTQFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T +A FK+ +D ++EVGLGG LD+TNIV V+V+T++ +DH + G E I Sbjct: 122 MLTAAAFLFFKEQGVDYAVVEVGLGGLLDSTNIVTPKVSVITNVTIDHQAYCGDTVEEIA 181 Query: 186 REKAGIFRSEKPAIVGEPEMP-STIADVAQEKGALLQRRGVEW-----NYSVTDHDWAFS 239 R KAGI + + P + + P + I DVA+++ A L ++ + S Sbjct: 182 RHKAGIIKPKVPVVTAAQDTPLNIIEDVAKKQHAKLYVFNKDFGIDSRSAVTGGQMITVS 241 Query: 240 DAHGTLENLPLPLVPQPN---AATALAALRASGLE---VSENAIRDGIASAILPGRFQIV 293 L + A AL A+R E +SE +R+G A GRF++ Sbjct: 242 TNDAAPAMLFTTMAGIHQSVNLACALMAVRLLMKEDTNISEETMREGFARTTWAGRFEVK 301 Query: 294 SE-SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 IFD AHN AE L K+ V+ +L DKD + + V D Sbjct: 302 RGLDRTFIFDGAHNAAGAESFAMTYDELFKDSPKTIVMAILKDKDQEAIIREVVKVGDTV 361 Query: 353 YCAPLEGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 P R E L+E + ++ DS+ A A K D + VCGS + Sbjct: 362 LVVPAPTDRTEVPETLVEMIRRTVPKATAQTADSIEAALALAYKHTKTGDIIAVCGSLYI 421 Query: 407 VAHVMEVI 414 + + Sbjct: 422 LGDARQWF 429 >UniRef50_Q47XK6 FolC bifunctional protein n=1 Tax=Colwellia psychrerythraea 34H RepID=Q47XK6_COLP3 Length = 437 Score = 425 bits (1094), Expect = e-117, Method: Composition-based stats. Identities = 177/425 (41%), Positives = 243/425 (57%), Gaps = 18/425 (4%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 Q + L WL YLENLHS IDLGL RV VA RL + V TVAGTNGKGTTC + Sbjct: 10 QDLTNLDQWLYYLENLHSTEIDLGLSRVGKVAERLAINLNFAKVITVAGTNGKGTTCAFI 69 Query: 68 ESILM-----AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 E+ L+ A+ V VYSSPH+ R+ ER+R+ Q++ + A +F IE AR DISL+ Sbjct: 70 ENALLNSKELASPRGVAVYSSPHIERFNERLRINKQDVEDQALINAFKRIEVAREDISLS 129 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 Y+EY TL+AL + +A +ILEVGLGGRLDATNI+DAD+AV+T+I LDH +LG DRE Sbjct: 130 YYEYTTLAALLVLMEAMPSFIILEVGLGGRLDATNIIDADIAVITTIDLDHQSFLGNDRE 189 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKG----ALLQRRGVEWNYSVTDHDWAF 238 SIG EKAGI R E+ ++G+ P ++ + A E + R ++ T W + Sbjct: 190 SIGFEKAGIMRQEQDIVIGDTNAPKSVINHANELHKNQVNRIFLRDQDFIVQNTQPHWNW 249 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 L L P +P+ N ATAL L L ++ + + + IA + GR +++ + Sbjct: 250 KTKQTQLTELKAPHIPRDNVATALMVLEKLNLTLTPDFVNEVIAKTKVAGRTELIKQKGL 309 Query: 299 --VIFDVAHNPHAAEYLTGRMKALPK---NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 VI DV HNP A YL G +K + + + AV+ ML DKDI+ +L LK +D WY Sbjct: 310 CDVILDVGHNPQATRYLAGYLKQIKEQANYQNIYAVVAMLGDKDISASLESLKDDIDFWY 369 Query: 354 CAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 L PR AT E + L + FD+V +A+ A A + D +LV GSF TV+ Sbjct: 370 TGALSVPRAATKETMASKLALFTNSVNCFDNVDEAFRMANKQANSSDLILVFGSFFTVSK 429 Query: 410 VMEVI 414 + + Sbjct: 430 IRAQL 434 >UniRef50_A8MIR1 FolC bifunctional protein n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MIR1_ALKOO Length = 439 Score = 425 bits (1094), Expect = e-117, Method: Composition-based stats. Identities = 110/426 (25%), Positives = 196/426 (46%), Gaps = 24/426 (5%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 + +++ +S L LE + ++ LG + +AGTNGKG+T + S+L A Sbjct: 5 EAVQFIDRSYSYGTKLDLEHMKILLQILGNPQNQLKFIHIAGTNGKGSTSSFIHSMLKAE 64 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEYGT 128 GY+VG+++SPHL YT+R+R+ G + + + +E +G F+ T Sbjct: 65 GYQVGLFTSPHLHCYTDRIRINGVNISKEDFARYTSMVEETIAPFYEQGFNHPALFDIVT 124 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGRE 187 L A+ F + +D V+LEVGLGG DATNI+ + +V+T I +DH D LG D + I Sbjct: 125 LVAMMYFAKENVDYVVLEVGLGGLNDATNIISQSLASVITPIGIDHVDILGTDLKQIAYH 184 Query: 188 KAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVE----WNYSVTDHDWAFSDA 241 KAGI +S+ I +P + + + A ++ A L E + + + + Sbjct: 185 KAGIIKSQGRVISTWQDPIVEEVLVETAAQQNASLCLLRKEQISIIHQDFKEQIFHLNTP 244 Query: 242 HGTLENLPLPLVPQPNAAT-ALAAL------RASGLEVSENAIRDGIASAILPGRFQIVS 294 +G L + + ++ ALAAL L +S +I G+ GR +++ Sbjct: 245 YGILRDCKIRMIGDHQIFNGALAALTLIILREDQILSISNESIYQGLYENYWAGRLELLQ 304 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 ++P ++ D AHN +E L + N ++ +IGML DKD+ G L L Sbjct: 305 DNPLILIDGAHNVQGSEVLASALTKYFNNKKITLIIGMLKDKDVDGVLNNLIPFAHKVIF 364 Query: 355 APLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 P+ ++L + ++ ++ A+ +A ++ + GS + + Sbjct: 365 TKPNNPKAMDPQELANRVNFFGKETYITQTIEESVVLALENASLDEITIFTGSLYLIGDA 424 Query: 411 MEVIDA 416 ++I Sbjct: 425 RKIITE 430 >UniRef50_Q38XD0 Putative polylpolyglutamate synthase n=1 Tax=Lactobacillus sakei subsp. sakei 23K RepID=Q38XD0_LACSS Length = 434 Score = 425 bits (1093), Expect = e-117, Method: Composition-based stats. Identities = 116/429 (27%), Positives = 192/429 (44%), Gaps = 23/429 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + + L+Y+ + + L R++ + A LG V GTNGKG+ + S+ Sbjct: 4 TDYETALAYIHSRPRLHKEANLNRMTQLLAALGNPHQGQQFIHVTGTNGKGSVVNMVSSL 63 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTAS-------FAEIESARGDISLTY 123 L+ G KVG Y+SP + R+ ER+ + Q + + A ++ A +T Sbjct: 64 LVELGLKVGRYTSPFITRFNERIAIDQQPIADDDLVAVTQHVQQTIETVQQADTTFEVTE 123 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T FKQ +D+ ++EVG+GG D+TN++ ++V+TS+ LDH LG + Sbjct: 124 FELITAIMFTYFKQQAVDIAVIEVGIGGLYDSTNVLTPLISVITSVGLDHQALLGDTLAA 183 Query: 184 IGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWN------YSVTDHD 235 I +KAGI +++ P ++G E + I + A+ + L GV+++ Sbjct: 184 IATQKAGIIKAQHPVVIGKLPAEAQTVIVETAKRLASPLAISGVDFSTTAVKTLPTWGQQ 243 Query: 236 WAFSDAHGTLENLPLPL---VPQPNAATALAA----LRASGLEVSENAIRDGIASAILPG 288 F + TL+ L +PL NAA AL L + + ++ G+A PG Sbjct: 244 LNFQNQTVTLKQLQIPLMGDYQIENAAVALETFCQYLALTQQPLDIKTLKRGLAHVSWPG 303 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 RF+ V++ P +I D AHNP E L K K+ + + G L DK +AG L L + Sbjct: 304 RFEKVNDEPLIILDGAHNPAGVEQLVKTAKHQFKHQDIYILFGALGDKSLAGMLPELNQL 363 Query: 349 VDDWYCAP-LEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 + PR AT Q A +++ A+D +LV GS + + Sbjct: 364 ATHLVLTTVPDNPRAATQAQYAAVDNTIPFEADWPVALTTMVSELSADDVLLVTGSLYLI 423 Query: 408 AHVMEVIDA 416 + + Sbjct: 424 STIRSYFKG 432 >UniRef50_A5N275 FolC n=22 Tax=Clostridium RepID=A5N275_CLOK5 Length = 450 Score = 424 bits (1092), Expect = e-117, Method: Composition-based stats. Identities = 111/445 (24%), Positives = 203/445 (45%), Gaps = 39/445 (8%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L Y+ N+ ++LGLER + LG VAGTNGKG+ + +LM Sbjct: 3 YKDTLQYINNIAKFGVNLGLERTEKILELLGNPHKKIKAVHVAGTNGKGSITVMISRVLM 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 AG+KVG+Y+SP+L ++ ER+++ G+ + + ++ A + + T FE Sbjct: 63 EAGFKVGMYTSPYLEKFEERIQINGKNISHDDLSRVVTKVSKAVDKVLQLGYDNPTEFEV 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDA---------DVAVVTSIALDHTDWL 177 T + + F + ++++ ++EVGLGGR D+TN++ + +V+ SI+ DH + L Sbjct: 123 ITCAMFYYFWEKKVEIAVIEVGLGGRFDSTNVMVSFAKECEGGVMASVIASISYDHMNIL 182 Query: 178 GPDRESIGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHD 235 G E I EKAGI + P I+ + I V +EKG+ L + V + + + Sbjct: 183 GDTLEKIAYEKAGIIKKGIPVILYPQSESVEKVIEKVCEEKGSELLKVPVNSSNLIGGNK 242 Query: 236 WAFSDAHGTLE----------NLPLPLVPQPNAATALAALRAS------GLEVSENAIRD 279 + ++ L L+ + AAL + V ++ I Sbjct: 243 IDSGSREYVQQVKIATKEADYDIKLSLLGKHQLLNCAAALFTLEQLSRYDILVDKSVISR 302 Query: 280 GIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIA 339 + + GR +++ +P V+ D AHN L + + ++ ++G+L DK++ Sbjct: 303 ALGNVSWKGRLEVMGRNPLVVIDGAHNIQGISMLKENICRYFQYNDMILILGILADKEVE 362 Query: 340 GTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAE 395 + + + + RG A +L +G N + F+ +A+ A++ E Sbjct: 363 KMVKTIVPLAKRVMAVTPKDKRGQIAGRLKTIIGKYNSNCEDFNDYEKAYRKALSYCSKE 422 Query: 396 DTVLVCGSFHTVAHVMEVIDARRSG 420 D +LVCGS + V + ++I +R G Sbjct: 423 DLILVCGSLYMVGDMRKII--KRHG 445 >UniRef50_B4RUR1 Bifunctional folylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Alteromonas macleodii RepID=B4RUR1_ALTMD Length = 443 Score = 424 bits (1092), Expect = e-117, Method: Composition-based stats. Identities = 183/418 (43%), Positives = 250/418 (59%), Gaps = 15/418 (3%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 L WLSYLE++H ID+GL+RV VA + + V TVAGTNGKGTTCR L Sbjct: 23 NTQKSLGQWLSYLESIHPSAIDMGLDRVKAVAQSMALSLSQSLVITVAGTNGKGTTCRLL 82 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD-----ISLT 122 E +++ G V VYSSPHL Y ERVR G+ P + +F +E +R + I+LT Sbjct: 83 EQAMLSQGKSVAVYSSPHLTDYRERVRYNGELPPANEFVKAFEFVEKSRKETEGDPITLT 142 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+GTL+A+ + + ++DVVILEVGLGGRLDATNI+ D+A++T+I LDH DWLG RE Sbjct: 143 YFEFGTLAAMKMMQSWEVDVVILEVGLGGRLDATNIIHPDLAIITTIDLDHQDWLGNTRE 202 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH--DWAFSD 240 I REKAGI R A+VG+ PS++ DV E A ++ ++ V +W++ Sbjct: 203 KIAREKAGIMRKNGNAVVGDLFPPSSLYDVVNELQANVRWATQDFVTVVASDYSEWSWKG 262 Query: 241 AHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 + + +LP P +P NA+TALAAL L E +RD I + +PGR + +SESP V+ Sbjct: 263 KNSSYASLPYPKIPLQNASTALAALELLELLPEEQVVRDIIKNTTMPGRQETISESPLVV 322 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHNP A + + + ++ V+GML DK IA TLA L ++ DWY A GP Sbjct: 323 VDVAHNPQATAEMQNWLNRYDVS-KMRIVVGMLKDKSIAETLAPLAALNADWYVASTSGP 381 Query: 361 RGATAEQLLEHLGNG-------KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 RG AE L L N ++F +V A+ A+AD + + +LV GSF TVA V+ Sbjct: 382 RGCEAEVLENALVNAGTTIENIETFQTVTSAYQRALADYQTGELILVFGSFVTVADVL 439 >UniRef50_A0YB05 FolC bifunctional protein n=1 Tax=marine gamma proteobacterium HTCC2143 RepID=A0YB05_9GAMM Length = 428 Score = 424 bits (1092), Expect = e-117, Method: Composition-based stats. Identities = 166/421 (39%), Positives = 243/421 (57%), Gaps = 15/421 (3%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L WL + E+ HS I+LGLERV VA +G+ V TVAGTNGKG+T L ++ Sbjct: 4 DTLNEWLVWQESCHSSEIELGLERVGAVARAMGLTLDRSKVITVAGTNGKGSTVAVLNTL 63 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L +AGY V ++SPH +RY ER+++ ++ + SF I+ ARG I LT+FE+GTL+ Sbjct: 64 LRSAGYSVACFTSPHFLRYNERIKLDDCDVSDQLLIESFDRIDQARGTIPLTFFEFGTLA 123 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ + + DV++LEVGLGGRLDA NI+DAD+AV+TSI +DH DWLG DRE IGREKAG Sbjct: 124 AIDICQHHNADVILLEVGLGGRLDAVNIIDADIAVITSIDIDHEDWLGSDREQIGREKAG 183 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV--TDHDWAFSDAHG----- 243 I RS KP + P+++ A + G + + G ++ Y W +S Sbjct: 184 IMRSGKPTVSAGLTPPASLQIEADKIGTTIYQAGRDFMYRQAREHGRWNWSGQSIDGQPV 243 Query: 244 TLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQ-IVSESPRVIFD 302 L L P +P + + AL L+ L +++ + +A+ L GRFQ V E +V+ D Sbjct: 244 ELLALQFPSLPAESVSAALQTLQLLDLPITKID-YNSLANVDLTGRFQCRVIEGKQVVLD 302 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPR 361 VAHNP AA YL R++ GR +A++ ++ DKDI G + L + D WY L + PR Sbjct: 303 VAHNPAAASYLAKRLQQTHGVGRTIALVAVMADKDIDGIVEPLINSFDTWYALELADVPR 362 Query: 362 GATAEQLLEHLGNGKSFD-----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 A L + + + D ++A A+ A++ + ED ++V GSF TVA ++E D Sbjct: 363 AMKASALAKKISSLTDVDVHVSSTIAIAFSDALSMMEKEDRLVVFGSFFTVAGLLEFADG 422 Query: 417 R 417 + Sbjct: 423 K 423 >UniRef50_C1I5V8 FolC bifunctional protein n=1 Tax=Clostridium sp. 7_2_43FAA RepID=C1I5V8_9CLOT Length = 432 Score = 424 bits (1091), Expect = e-117, Method: Composition-based stats. Identities = 116/424 (27%), Positives = 194/424 (45%), Gaps = 25/424 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + YLE L + GLER + LG + +AGTNGKG+T L +L+ GY Sbjct: 7 IKYLEELRVLGSNYGLERTERLLELLGNPHKKLKLIHIAGTNGKGSTSSILGKVLIEHGY 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEYGTLS 130 KVG ++SPHL E +RV + +PE EI+ G T FE T Sbjct: 67 KVGFFNSPHLEEIEETIRVNDENIPEEDLVYLLEEIKPYVNKVVEEGYKHPTEFEVLTCI 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 + ++D ++EVGLGGRLD+TN++ ++++TSI+LDHT+ LG + I EKAG Sbjct: 127 MFLYLYRQKVDFGVIEVGLGGRLDSTNVIKPILSIITSISLDHTNILGNTIQEITNEKAG 186 Query: 191 IFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRG---------VEWNYSVTDHDWAFS 239 I + P I E I + A + L V + F+ Sbjct: 187 IIKDAIPVITCNQKDEALYIIKNKALLTKSKLTIVDSNDFVFLEIVNDDIPYQRVSVNFN 246 Query: 240 DAHGTLENLPLPLVPQPNAATALAALRASG----LEVSENAIRDGIASAILPGRFQIVSE 295 + TL+ L N + A+ AL ++V+ N + G+ + GR +++ + Sbjct: 247 NNKYTLDLALLGKHQIINLSLAIKALEELEKLNYIKVNINKLYKGVKNVKWKGRLEVLKK 306 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 P ++ D AHN E+L ++ K + ++G+L DK++ + + V + Y Sbjct: 307 DPFIVIDGAHNIAGIEFLKSNIEEYFKYKNLYLILGILADKNVEEMVKIIAPVATEVYTV 366 Query: 356 PLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 R A+A +L E + N +FD +A +++ A +D ++ GS + + + Sbjct: 367 TANSIRAASANELKEVVLEYNNNCIAFDDYDKAIKLSLSKANKDDLIVAAGSLYMIGEIR 426 Query: 412 EVID 415 + I+ Sbjct: 427 KQIN 430 >UniRef50_B9L391 Folylpolyglutamate synthase (Folylpoly-gamma-glutamatesynthetase) n=2 Tax=Thermomicrobia (class) RepID=B9L391_THERP Length = 454 Score = 424 bits (1091), Expect = e-117, Method: Composition-based stats. Identities = 144/406 (35%), Positives = 206/406 (50%), Gaps = 22/406 (5%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GL R + + + LG +AGT GKG+T L S+L AAGY+VG+Y+SPHL Sbjct: 34 GLARTAWLCSALGDPHRRYRSVHIAGTKGKGSTAALLSSMLQAAGYRVGLYTSPHLHTLR 93 Query: 91 ERVRVQGQELPESAH---TASFAEIESARGDISL-----TYFEYGTLSALWLFKQAQLDV 142 ER+++ GQ + A AE+++A T FE T+ A F + +D+ Sbjct: 94 ERIQIDGQPIAPETFGTLMAELAEVDAALQRAHPDWGAATAFELVTVLAFAAFARVPVDI 153 Query: 143 VILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG- 201 ++EVGLGGRLDATN++ DVA++T I DH LG +I REKAGI + +P + Sbjct: 154 AVIEVGLGGRLDATNVILPDVALITRIGYDHMAILGSTLAAIAREKAGIVKPGRPVVSAP 213 Query: 202 -EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAAT 260 EPE I VAQE+GA L G +W + T +AF L +L L L Sbjct: 214 QEPEATRVIEAVAQERGAPLWLGGRDWQVTGTWRRFAFHAPGWELADLALALRGSHQVEN 273 Query: 261 ALAALRASGLE------VSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLT 314 A AL + E+AIR G+A+A+ PGR +++ E+P V+ D AHN +A+ L Sbjct: 274 AGVALASLPWLARVEMVAPESAIRQGLATAVWPGRLELLRENPSVVVDGAHNRESAQRLA 333 Query: 315 GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN 374 + + R+ V+G++ DK+I +A L + D + PR A+AE+LL Sbjct: 334 EAVHESFRWRRLWLVLGIMRDKEIERIVAALAPLADALFAVEGFAPRAASAERLLAAWAA 393 Query: 375 ------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 S+ SV A AA+ A D VLV GS VA E + Sbjct: 394 STVGKPAASYRSVEDALRAALEQADPADLVLVTGSLSMVAAAREAL 439 >UniRef50_Q6AJ73 Related to folylpolyglutamate synthase n=3 Tax=Deltaproteobacteria RepID=Q6AJ73_DESPS Length = 441 Score = 424 bits (1091), Expect = e-117, Method: Composition-based stats. Identities = 129/426 (30%), Positives = 202/426 (47%), Gaps = 23/426 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 S L++L++L I LGL + A + V VAGTNGKG+ C +L S+ Sbjct: 12 SRYQDALAFLDSLQFHKIKLGLAPMRDFLALFDNPEAKMKVVHVAGTNGKGSVCSSLVSV 71 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L GY++G+Y+SPHL ER R+ + + + I + +TYFE+ T Sbjct: 72 LAKGGYQLGLYTSPHLSSPRERFRINDEYISRADFACLTDRIRTRLAGRPITYFEFTTAL 131 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKA 189 A F + +D+V+LE GLGGRLDATN+V + ++TSI++DH +LG E++ EKA Sbjct: 132 AFLWFYERGVDLVVLETGLGGRLDATNVVRQPLLTIITSISIDHVAYLGDTIEAVASEKA 191 Query: 190 GIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYS-VTDHDWAFSDAH---- 242 GI + P + G +P++ + +A A+EK A L G +++ + W + Sbjct: 192 GIIKEGVPVVCGSYDPKVVAVVAGFAREKKAPLYLAGRDFDAHWLAGASWDYQGEGFLAD 251 Query: 243 ---GTLENLPLPLVPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVS-- 294 +EN + N A L L+ G VSE+ +R G+ S PGR + + Sbjct: 252 ASLQAVENAKPGRIQAENGALVLTTLCLLKRHGFVVSEDELRSGLFSVSWPGRLEYLQLD 311 Query: 295 ESP-RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 SP + D AHNP L + AL R++ V G + DKDIA L + VD Sbjct: 312 RSPAPYLLDGAHNPAGIASLVEAL-ALYSYRRLICVWGAMADKDIATGLNRIVPHVDLLC 370 Query: 354 CAPLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 ++ R A + L F S + A + A A +D +L+ GS + + Sbjct: 371 LTAVDSERAAEPAAMFALLTEDDRKKTTCFTSSSLALEYAERMAGKDDLILIAGSLYLMG 430 Query: 409 HVMEVI 414 + ++ Sbjct: 431 ELRPIL 436 >UniRef50_Q12D50 FolC bifunctional protein n=4 Tax=Proteobacteria RepID=Q12D50_POLSJ Length = 501 Score = 423 bits (1089), Expect = e-117, Method: Composition-based stats. Identities = 185/479 (38%), Positives = 248/479 (51%), Gaps = 75/479 (15%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + L WL++ E LH K+ID+GLERV VA R+G+ A V TVAGTNGKG+TC L Sbjct: 11 EQLKTLQDWLAHCERLHPKSIDMGLERVQAVARRMGLAF-ACPVITVAGTNGKGSTCAML 69 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR----GDISLTY 123 E+IL+ AGY+ GVY+SPHLV + ER RV+G + + A+FA +E+AR +ISLTY Sbjct: 70 EAILLEAGYRTGVYTSPHLVHFEERCRVRGDIVNATDLVANFARVEAARVQNGDEISLTY 129 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE+ TL+ L L A+LDVVILEVGLGGRLDA NI+D D AV+TSI LDH ++LG DRES Sbjct: 130 FEFTTLAILQLLADAKLDVVILEVGLGGRLDAVNILDTDCAVITSIDLDHMEFLGNDRES 189 Query: 184 IGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 IGREKAGI R+ KP +V +P P +I D A GA L R G ++N+S W++ Sbjct: 190 IGREKAGIMRAGKPVVVSDPVPPQSILDHAAALGADLWRFGQDFNFSGDKQQWSWVGRAD 249 Query: 244 T------------------------LENLPLPLV--------------------PQPNAA 259 T + P + A Sbjct: 250 TGPPQGSTAPSGGSAVHEVTSVGAKVRRAGPPQASTAPSGGSAAHEVASVGAKTYRRYAG 309 Query: 260 TALAALRASGLEVSENAIRDGIAS------------------AILPGRFQIVSESPRVIF 301 A ALR + V+ + + + + LPGRFQIV P ++ Sbjct: 310 LAYPALRGANQLVNASGVLAALTALRDRLPVTAQAVRNGLSMVELPGRFQIVPGQPTLVL 369 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 DVAHNPH+ L + A+ AV G + DKD+A LA + ++D WY L R Sbjct: 370 DVAHNPHSVAALAENLDAMGFYPCTHAVFGAMADKDLAPMLARVGPLIDKWYFTDLPTAR 429 Query: 362 GATAEQLLEHLGNGKSFDSVAQ--------AWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A+ E+L +S V A AA+ A D ++V GSF+TV V++ Sbjct: 430 AASGEELAAKWQAVESRPDVTATTHKDPELALQAAVRAAGPADRIVVFGSFYTVGGVLK 488 >UniRef50_A1U0X0 FolC bifunctional protein n=3 Tax=Marinobacter RepID=A1U0X0_MARAV Length = 438 Score = 423 bits (1088), Expect = e-117, Method: Composition-based stats. Identities = 176/416 (42%), Positives = 244/416 (58%), Gaps = 8/416 (1%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P + + WL +LE +H IDLGL+RV +V RL KP + TVAGTNGKGTT Sbjct: 16 PARGASVQEWLHWLEAIHPTEIDLGLDRVLVVLRRLFPRKPQARIITVAGTNGKGTTVTA 75 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 LESIL+AAG G Y SPHL RY ERVR+ GQE+ ++A +F +E+AR ++LTYFE+ Sbjct: 76 LESILLAAGRSTGAYVSPHLFRYNERVRIGGQEISDAALVTAFERVEAARRGVTLTYFEF 135 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 GTL+A F A ++ +LEVGLGGRLDA N++D D AV+TS+ +DH +LG +RE IG Sbjct: 136 GTLAAFVAFAGAGVENWVLEVGLGGRLDAVNVLDPDYAVITSVDIDHIGFLGDNREVIGF 195 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 EKAGI R PA+ +P PS++ A + L+ G ++ + Sbjct: 196 EKAGILRPGIPAVCADPNPPSSVLQQAAAQKVALKLTGRDYTLAPGAPGQVLLTIGDEKI 255 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 LP +P + A A R E+S +++ I + +PGRF+ + P VI DV HN Sbjct: 256 ELPAGPLPVQSVAAAAVLSRQLVPELSLESLQHAIQNVRVPGRFETIHHDPDVIIDVGHN 315 Query: 307 PHAAEYLTGRMKALPKN--GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 PHAA +L ++ L GR+LAV G L DKD+ G + + SVVD WY A L+ PRG Sbjct: 316 PHAAAWLADNLRRLRCGGPGRILAVYGALGDKDVEGVVGAMSSVVDQWYLAGLDVPRGLD 375 Query: 365 AEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 ++ L++ + G +F SV++A AAM AK+ D ++V GSF TVA E + Sbjct: 376 SDSLMKRISTVALQGKPGAFGSVSEALAAAMKAAKSGDRIVVFGSFFTVALAREEL 431 >UniRef50_Q28WD6 FolC bifunctional protein n=2 Tax=Rhodobacterales RepID=Q28WD6_JANSC Length = 421 Score = 422 bits (1086), Expect = e-116, Method: Composition-based stats. Identities = 146/419 (34%), Positives = 207/419 (49%), Gaps = 26/419 (6%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESILM 72 L+ + LH K IDL L+R+ + LG + P V VAGTNGKG+T + + L Sbjct: 6 DQLLARMMALHPKIIDLTLDRMWRILYALGDPQTRIPPVIHVAGTNGKGSTQAMIRAGLE 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AG Y+SPHL R+ ER+R+ G+ + E + +A G +TYFE T +AL Sbjct: 66 GAGLTTHAYTSPHLARFHERIRLAGELIDEDHLSRILDTCLAANGPDPITYFEITTAAAL 125 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGI 191 F Q D +LEVGLGGRLDATN++DA ++V+T I LDH +LG E+I EKAGI Sbjct: 126 HAFAQMPADYTLLEVGLGGRLDATNVIDAPALSVITPIDLDHQQFLGDTLEAIAGEKAGI 185 Query: 192 FRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 + P +VG E I A GA + G W+ + F D G L +LP Sbjct: 186 IKRGIPVVVGPQQDEALEVIEARAARLGAPVIAHGQHWHVTTERERLIFQDETGLL-DLP 244 Query: 250 LPLV----PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR------- 298 LP + NA TALAALR G+ ++ A+ D I P R Q + P Sbjct: 245 LPSLAGPHQIQNAGTALAALRTLGVGDADAAMTD----TIWPARMQKLRHGPLTEVAPSV 300 Query: 299 -VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 + D HNPHAA + ++ LPK + GML+ KD+ G +A L V+ + Sbjct: 301 ELWLDGGHNPHAARAIAATLETLPK-RPTYLICGMLNTKDVTGYMAPLVPWVESLTAVSI 359 Query: 358 EGPRG-ATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAED---TVLVCGSFHTVAHVME 412 G +AE+ E + +A DAA+ + +D VL+CGS + +++ Sbjct: 360 PGQTATLSAEETAEAARSVGLTTRIAPGVDAALTEIAVDDPRARVLICGSLYLAGEILK 418 >UniRef50_C0CJ78 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0CJ78_9FIRM Length = 433 Score = 422 bits (1086), Expect = e-116, Method: Composition-based stats. Identities = 118/420 (28%), Positives = 184/420 (43%), Gaps = 21/420 (5%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 +Y++ + LGLE + + +LG + V VAGTNGKG+T L +IL AGYK Sbjct: 8 AYIDQVECYGRVLGLENIEELTQKLGNPQEDLNVIHVAGTNGKGSTIAYLSTILQEAGYK 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAE------IESARGDISLTYFEYGTLSA 131 VG Y SP + Y ER+ + +++ + A + +A+G T FE T A Sbjct: 68 VGKYISPTIYSYRERMSIGEKKISKEAFARHLTKVAAVAEEMAAQGRPHPTPFEIETAVA 127 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDA-DVAVVTSIALDHTDWLGPDRESIGREKAG 190 F++ + D V+LE G+GG DATN+V +AV+T I LDH +LG I KAG Sbjct: 128 FLFFREEKCDFVVLETGMGGATDATNVVRNTRMAVLTPIGLDHMSFLGNTLSEIAAVKAG 187 Query: 191 IFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 I + + + E I Q+K + L + V + EN Sbjct: 188 IIKEGCVTVCSCQKAEAREVIEQECQKKHSELIWVDTK-TLKVKETSCFGQTFQWEGENY 246 Query: 249 PLPL---VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 + L NA AL A LR G E+ + A+ G+++ GRF ++ +SP + D Sbjct: 247 EVSLAGVYQIDNAVLALTAVTQLRKMGYEIPKEAVSRGLSNTRWGGRFTVIGQSPLFVVD 306 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP-LEGPR 361 AHNP AA L + + + ++GM DKD L + R Sbjct: 307 GAHNPDAARRLEESICQYFSHKNIYYIVGMFRDKDYDEVLRITAPYAKGIFTVQTPNSQR 366 Query: 362 GATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 +A +L E G ++ + +A A A +D ++ GS + + ++ R Sbjct: 367 ALSARELAEDAGKYHDRVEAVSDLTEAVKRAYEVAGPQDVIVAFGSLSYLGEITRIVRER 426 >UniRef50_Q2SJC8 Folylpolyglutamate synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SJC8_HAHCH Length = 430 Score = 422 bits (1086), Expect = e-116, Method: Composition-based stats. Identities = 169/413 (40%), Positives = 238/413 (57%), Gaps = 13/413 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARL-GVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L+ WL Y+ LHS+ I++GL+RV+ V RL + A V T+AGTNGKG+T +E++ Sbjct: 6 LSDWLDYVSQLHSQVIEMGLDRVNDVFRRLCRNARLAKTVVTIAGTNGKGSTLAAVEALA 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 +AAG VG Y+SPH++R+ ERVR+ G ++ + A A+FA +ESARG +LTYFE+ TL Sbjct: 66 LAAGKTVGAYTSPHILRFNERVRINGVDVSDEALEAAFAAVESARGQTALTYFEFTTLVG 125 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 +LF+QA+LD+V+LEVGLGGRLDA NIVD D+AV+TS+ LDH +WLG RE IGREKAGI Sbjct: 126 FYLFQQARLDLVLLEVGLGGRLDAVNIVDPDLAVITSVDLDHQEWLGESREDIGREKAGI 185 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH-----DWAFSDAHG--T 244 R P I+ E P+++ DVA + G ++ T W H Sbjct: 186 LRPGIPLIIAEEAPPTSVVDVAGKLGCATFIWRQDFTLERTGDASQALQWRGRRKHADIV 245 Query: 245 LENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 ++ L +P N A A+ +SE+ + IA +PGRFQ++ P V DV Sbjct: 246 VDGLSDNGLPMANMAAAMQVAMLLDFPLSESQVAAVIAGVKVPGRFQLLRRDPEVYADVG 305 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNPHAA YL + LP +AV L DKD+AG + L V D W PL R Sbjct: 306 HNPHAARYLKQWLGGLPVKKPQIAVFSALKDKDVAGIVKELAGVFDRWIVFPLNVDRAMP 365 Query: 365 AEQLLEHLGNGKSFD-----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 QL E + +S S+++ A ++A ++ ++ GSF TVA + + Sbjct: 366 LAQLAELVERNQSAPLQTCASLSECLAQATSEAGSDGRIVAFGSFFTVAEIFQ 418 >UniRef50_C9L620 Tetrahydrofolate synthase n=1 Tax=Blautia hansenii DSM 20583 RepID=C9L620_RUMHA Length = 432 Score = 422 bits (1086), Expect = e-116, Method: Composition-based stats. Identities = 126/424 (29%), Positives = 199/424 (46%), Gaps = 22/424 (5%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL+ LGLE + + RL + + ++GTNGKGT L +IL AGY+ Sbjct: 9 YLDETSKYGSVLGLENMKALLDRLDNPQESLKFIHISGTNGKGTVLAYLSTILRKAGYRT 68 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LTYFEYGTLSAL 132 G Y SP L Y ER++V +++ + A I +A D+ T FE T A Sbjct: 69 GRYISPTLFSYRERIQVNEEKIEKEALAQHVTAIAAAVADMKEKKAGTPTAFEIETALAF 128 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 FK+ D+V+LE GLGG LDATNI+ + V+ I++DHTD LG + I +KAGI Sbjct: 129 LYFKEKNCDIVVLETGLGGALDATNIIQTTQLEVIAPISMDHTDVLGKTLKEIAAQKAGI 188 Query: 192 FRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 + + E E + V +EK + + + S ++ +N+ Sbjct: 189 IKPHTTMVTAVQEEEAKEVLQKVCKEKESRFCEVEKDEISDIQYGYIRQSFSYKNWKNVE 248 Query: 250 LPL---VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 + L N A AL A LR GL + A+ G+ A GRF ++S++P VI D Sbjct: 249 ISLAGEFQIQNGALALEAVNQLRKLGLSLPNEAVYAGMKEAKWVGRFTVMSQNPLVILDG 308 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP-LEGPRG 362 AHNP AAE L ++ K ++ V G+ DKD + + + + PR Sbjct: 309 AHNPQAAEALRKSLELYFKGKKLYYVFGVFQDKDYKKIIELTAPLAEHIITVETPDNPRA 368 Query: 363 ATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID--A 416 AE+L + + + ++ +S+ A + ++ AED ++V GS + +V+ Sbjct: 369 LPAEELKKQVEKINASVETGESIEAAIEKNLSYMGAEDVLVVFGSLSFLGIAAKVLQGGG 428 Query: 417 RRSG 420 R++G Sbjct: 429 RKNG 432 >UniRef50_Q5WEQ5 Folylpolyglutamate synthase n=1 Tax=Bacillus clausii KSM-K16 RepID=Q5WEQ5_BACSK Length = 436 Score = 421 bits (1083), Expect = e-116, Method: Composition-based stats. Identities = 108/429 (25%), Positives = 195/429 (45%), Gaps = 22/429 (5%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 + ++ +L I GL+R+ + LG + VAGTNGKG+T L IL A Sbjct: 7 EEAVQWIHSLLPFGIKPGLKRMEWMLEALGHPEQRLTAVHVAGTNGKGSTVSFLRHILTA 66 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYG 127 G+ VG ++SP++ +++ER+ V G + + + ++ ++ S T FE Sbjct: 67 GGFSVGTFTSPYIEQFSERISVNGVPISDRDLLQAAQRLKPIVEEVAQSDLGSPTEFEVL 126 Query: 128 TLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T + F + A+ D+ ++EVGLGGRLD+TN+V ++++T I DH LG I Sbjct: 127 TAMMFYHFAEVAKPDICLIEVGLGGRLDSTNVVTPVLSIITMIGHDHMHILGHTLAEIAY 186 Query: 187 EKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY-SVTDHDWAFSDAHG 243 EKAGI + P I G E + I++ A++ G+ L + + S+ + + + Sbjct: 187 EKAGIIKPGIPVISGVEGEEAYTVISETARQIGSPLHQLNETFLVESLQGRTFTYKEEKD 246 Query: 244 ----TLENLPLPLVPQPNAATALAALR----ASGLEVSENAIRDGIASAILPGRFQIVSE 295 NAA AL A+ + ++ + A GIA+ PGRF+I+ Sbjct: 247 EEAVRYHAGLYGSHQHKNAALALKAVSLLSNSLKRQIGKEAKAIGIANTSWPGRFEIIQV 306 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW--Y 353 +P ++ D AHN LT ++ + + ++ +KD+ L + + Sbjct: 307 NPPIVLDGAHNEEGFLALTAALQERFSDKNIHVLLASTTEKDMNVLLKPFATSGLEVAFS 366 Query: 354 CAPLEGPRGATAEQLLEH--LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 + R A AE L + + + +A M + +D ++V GS + ++ V Sbjct: 367 FTSFDFHRAANAEDLFKQAPVKRKQVAADWRKALKTMMENLGEQDVLVVTGSLYFISEVR 426 Query: 412 EVIDARRSG 420 + + + + G Sbjct: 427 QSLASYKEG 435 >UniRef50_C5CFS4 FolC bifunctional protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CFS4_KOSOT Length = 443 Score = 421 bits (1082), Expect = e-116, Method: Composition-based stats. Identities = 114/428 (26%), Positives = 199/428 (46%), Gaps = 31/428 (7%) Query: 15 SWLSYLENLHSKT-IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 L YL + I GL R+ + RLG + + + GTNGKG+ L+ +L A Sbjct: 8 EALEYLYSSRPYGKIKYGLFRIEELMERLGNPQESYPTIHITGTNGKGSVATILKGVLEA 67 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-------DISLTYFEY 126 G VG+ SPH+V + ER+++ + + E + EI A + + ++FE Sbjct: 68 HGLHVGMNISPHIVSFRERIQLDNRYITEEEVCETLKEILPAIETMDKKGPEYAPSFFEV 127 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIG 185 T A F++ ++DV ++EVGLGGR DATNI+ V+V+T+++LDH + LG + E I Sbjct: 128 VTAMAFHFFRKKKVDVAVIEVGLGGRYDATNIIKKPLVSVITTVSLDHKNILGKNEEKIA 187 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYS-----VTDHDWAF 238 EKAGI + P + G P + TI + A EK A ++ + ++ + + Sbjct: 188 IEKAGIIKEGVPVVSGVTRPSIRYTIEEKAGEKNAPSYFLWKDFQVETKELKINENVYNY 247 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASGL-------EVSENAIRDGIASAILPGRFQ 291 S T NL L L A A++ + ++ +RD + PGRF+ Sbjct: 248 SGEE-TYPNLVLSLNGTHQARNLAVAMKTLEIAFNGLKKKIDNAKLRDSLKKTSWPGRFE 306 Query: 292 IV-SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 ++ ++ ++I D AHN A L ++ ++ + G L DKD ++ L + Sbjct: 307 VLTHKNRKIILDGAHNIDGAYALRNSLEIYFPGQKLDIIFGSLDDKDYESVISILAPISG 366 Query: 351 DWYCAPLEGPRGATAEQLLE----HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 + R E++ E + GN + +A++ + T+L+ GS + Sbjct: 367 KVVVTKVPSHRSINPERVREIWKVYHGNVEFITEPDRAFEKFFNSTQN--TLLITGSLYL 424 Query: 407 VAHVMEVI 414 V+++ +I Sbjct: 425 VSYLRNLI 432 >UniRef50_Q1WT76 Folylpolyglutamate synthase / Dihydrofolate synthase n=2 Tax=Lactobacillus salivarius RepID=Q1WT76_LACS1 Length = 433 Score = 420 bits (1081), Expect = e-116, Method: Composition-based stats. Identities = 104/428 (24%), Positives = 186/428 (43%), Gaps = 24/428 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+++ L+R+ RLG V GTNGKG+T L ++ Sbjct: 6 YNDALAFIHGRTKFKKIPTLDRMRDFMKRLGNPHEKVKAIHVTGTNGKGSTTAYLRDLIA 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS---------LTY 123 GY VG ++SP + ++ ER+ V G+ + + I ++ T Sbjct: 66 EQGYNVGTFTSPFIEKFNERISVNGKMISDEEIVRLVNIIGPVVKEMDSDWRDREGGPTE 125 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T F + +D ++EVG+GG D+TN++ ++V+T++A+DH LG Sbjct: 126 FEIVTAMMFVYFAEGHVDYAVIEVGIGGLFDSTNVITPLMSVITTVAMDHAHILGDTIAK 185 Query: 184 IGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT-----DHDW 236 I KAGI + +KP ++G E + VA+EK A L +++ V + Sbjct: 186 IATHKAGIIKYKKPILIGKLPDEAIKVVKQVAKEKEAPLLIMDKDFSSKVKLEQGWGEKF 245 Query: 237 AFSDAHGTLENLPLPL---VPQPNAATALAAL----RASGLEVSENAIRDGIASAILPGR 289 FSD+ G + N+ + + NA A+ G+ S I++ I GR Sbjct: 246 DFSDSRGEISNIHISMEGFHQIENATLAIETFIQFAELEGINYSNKDIKNAIQKTQWLGR 305 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 F+++++ P V+ D AHN A + ++ ++ + V ++ +L DK L L + Sbjct: 306 FELLNKEPLVVIDGAHNTAAMKRISQLLRKEFADREVYVILAILADKQPNEMLDELLKLP 365 Query: 350 D-DWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 + EGPR T + N K + +A +++ +D +L+ GS + ++ Sbjct: 366 NVHVTVTRFEGPRKVTKLADFKLHDNVKYVEHWQEAIGEVISNMSLDDMLLITGSLYFIS 425 Query: 409 HVMEVIDA 416 V + Sbjct: 426 EVRNNFEG 433 >UniRef50_C6J218 Bifunctional protein folC n=1 Tax=Paenibacillus sp. oral taxon 786 str. D14 RepID=C6J218_9BACL Length = 462 Score = 420 bits (1080), Expect = e-116, Method: Composition-based stats. Identities = 122/445 (27%), Positives = 202/445 (45%), Gaps = 36/445 (8%) Query: 5 RTPQAASPLASW---LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 RT + PL S+ + ++ L I GLER+ L+ +LG + VAGTNGKG Sbjct: 9 RTEEETRPLNSYAEAVDWINGLLPFGIRPGLERIELMMEKLGHPERRLKFIHVAGTNGKG 68 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-- 119 ++C L L GY VG Y+SP++ ++T R + +++PE+ + +I Sbjct: 69 SSCAFLTRTLRECGYHVGTYTSPYITKFTNRFQYDEEDIPETVLLELANRVAPLVAEIAG 128 Query: 120 ----SLTYFEYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHT 174 S T FE T A+ F + DVV+ E GLGGR+D TNIV V+++T+I LDH Sbjct: 129 TELGSPTMFEVSTAIAILYFAEVCYPDVVVWETGLGGRMDVTNIVTPIVSLITNIGLDHM 188 Query: 175 DWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYS-- 230 D LG E I REKAGI ++ P + +PE + + + A K A L G ++ Y Sbjct: 189 DVLGDTIEQIAREKAGIIKAGVPVVSCAEQPEAVAVLKETAAAKHATLYLMGEQFRYERV 248 Query: 231 ---VTDHDWAFSDAHGTLENLPLPLVPQPNAATA------LAALRA-SGLEVSENAIRDG 280 + F + + + ++ + A L LR + + ++DG Sbjct: 249 AVDAKEQQLHFQGPFREM-DFTIRMLGEHQCKNAAGVMMVLEVLRQYMAFILEDEQVQDG 307 Query: 281 IASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAG 340 ++ GR ++V E PR++ D AHNP A L + + ++ ++GML +K G Sbjct: 308 FRTSFWAGRLEVVREEPRLVLDGAHNPEGAASLAKSLPEAFQYRKLHLMMGMLANKHHQG 367 Query: 341 TLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFD-----------SVAQAWDAAM 389 L + +VD + R A+ L E + + + +A Sbjct: 368 YLKHILPIVDTLILTEPDFRRKMDADALYELVAELQGIEAKADLEIIVERDWRKALSLLE 427 Query: 390 ADAKAEDTVLVCGSFHTVAHVMEVI 414 + + ED +V G+ + ++ V + Sbjct: 428 SRTEREDLGVVTGTLYLISDVRAAL 452 >UniRef50_C0QUQ6 Folylpolyglutamate synthetase n=2 Tax=Aquificales RepID=C0QUQ6_PERMH Length = 406 Score = 419 bits (1079), Expect = e-116, Method: Composition-based stats. Identities = 113/406 (27%), Positives = 190/406 (46%), Gaps = 9/406 (2%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L L N I LER+ +G + ++GTNGKG+T LES+L G Sbjct: 3 LYRLFNRKVFHIQPDLERIKKALEEIGEPQKEFPSILISGTNGKGSTAVYLESLLRYHGL 62 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFK 136 K G+++SPH++ ER +V + + EIE LTYFE + A F Sbjct: 63 KTGLFTSPHIMEENERWQVNRKSIEVDKLDRYIKEIEDLIKRYDLTYFEASAVIAFRYFL 122 Query: 137 QAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEK 196 +D+ +LEVGLGGR DATN+V +++V+T+++LDHTD LG I REK GI R ++ Sbjct: 123 DENVDIAVLEVGLGGRWDATNVVYPEISVITNVSLDHTDLLGNSLMEIAREKLGITRKDR 182 Query: 197 PAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQP 256 P ++G + I+ + + + + Y + D + + ++ ++ Sbjct: 183 PVVIG-TDQMEIISQAVMKGIKEIYHYPIGFTYQIKDRSMDYIFKGKEIRDIRTSILGDR 241 Query: 257 NAATALAALRA-------SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHA 309 + A AL A G++V + ++ I+ + +PGR QI+ E P VI D AHN A Sbjct: 242 QLSNAATALTAFLLYSERKGIKVDDEKVKKAISGSFIPGRMQILKEEPPVIVDGAHNLDA 301 Query: 310 AEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLL 369 +K L +++ V + DKD + ++S D L R T +++ Sbjct: 302 VSKTVEEVKRLYPGRKIITVFSCMKDKDYKSIIHIIRSSSDRVIATKLPFSRSITEDEIS 361 Query: 370 EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + + + A A+ +A ++ VL+ GS + +++ I Sbjct: 362 Q-FKDIDFIPDIDGALKKAIEEADSKSVVLITGSLYLAGEILKKIK 406 >UniRef50_A9KNK7 FolC bifunctional protein n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KNK7_CLOPH Length = 424 Score = 419 bits (1077), Expect = e-115, Method: Composition-based stats. Identities = 123/420 (29%), Positives = 201/420 (47%), Gaps = 23/420 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + YL + T +L L+ ++ + + + VAGTNGKG+TC+ L SIL Sbjct: 3 YQEAIKYLRSYKRNTGELSLKNLNKLLDYMDHPEKKLKFIHVAGTNGKGSTCKMLSSILR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG----DISLTYFEYGT 128 AG KVG+++SP L E++++ G+ + +++ D T FE T Sbjct: 63 CAGLKVGLFTSPFLETENEQIQINGEVISNEDFAKVCKKVKDFTTYLMLDEIPTEFELTT 122 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGRE 187 A F + D+V+LEVGLGG LDATN+++ V+V+T+I +DH D+LG + I + Sbjct: 123 AMAFQYFYDTKCDLVVLEVGLGGELDATNVIETPLVSVLTNIGIDHVDYLGTTLKEIACK 182 Query: 188 KAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 KAGI + + E E+ I +E+ L E++ + H S + Sbjct: 183 KAGIIKENGIVVSYEQEKEVEEVIKLTCEERHNKLVFA--EFS-ELKLHQENLSRQKFSY 239 Query: 246 E---NLPLPLVPQPN---AATAL---AALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 + NL L L+ + AA AL A L+ G ++SENAI +G+ PGRF+++ + Sbjct: 240 KQNTNLSLSLIGEHQRKNAAVALEVIAQLQTLGYKISENAISEGMNYVTWPGRFEVLCKQ 299 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P VI D HN E + +K + + ++G+L DKD G + +L + Sbjct: 300 PLVILDGGHNVQCVEAFSEVLKQFIPGKKAIVILGVLADKDYKGMIPYLVPFTKRFIAVT 359 Query: 357 LEGPRGATAEQLLEHLGNGKSF----DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 + R +EQL E L + + AA+ DA+ +D + V GS + A + + Sbjct: 360 PKNTRALPSEQLAEELSKHHPLVSHNATPVEGIMAALRDAREDDIICVIGSLYMAAEIRD 419 >UniRef50_Q1QDK0 FolC bifunctional protein n=4 Tax=Moraxellaceae RepID=Q1QDK0_PSYCK Length = 457 Score = 418 bits (1076), Expect = e-115, Method: Composition-based stats. Identities = 165/451 (36%), Positives = 247/451 (54%), Gaps = 39/451 (8%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLK---PAPFVFTVAGTNG 59 TP + L WL+Y++ +H ID+GL RV VA LGV++ +VFTVAGTNG Sbjct: 10 PSSTPDNQATLTEWLNYMQQIHVSAIDMGLSRVLPVAEALGVVQSAKDDAYVFTVAGTNG 69 Query: 60 KGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-- 117 KG+T + + AAGYK +Y SPHL + ERVR+ G+ + + A+F+++E+AR Sbjct: 70 KGSTTAVIAQMCQAAGYKTALYQSPHLSVFNERVRIDGEMVSDETLIAAFSKVEAARLQC 129 Query: 118 DISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWL 177 D++L++FE TL+AL +F +A DV +LEVGLGGRLD NI+D D+AV+T+IA+DH DWL Sbjct: 130 DLTLSFFEMTTLAALLIFAEADCDVWVLEVGLGGRLDVVNIIDPDMAVITNIAIDHVDWL 189 Query: 178 GPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNY-SVTDHDW 236 G + E+IG EKAGI R I G EMP+++ + A + E++Y W Sbjct: 190 GDNVEAIGAEKAGILRDGISVIYGATEMPNSVQQAIDKHQATCYQVSKEFSYCENNSTRW 249 Query: 237 AFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRF---QIV 293 +S+A TL+ LP P + N A AL+A+ AS L+V NAI + + L GRF ++ Sbjct: 250 QYSNAAVTLQ-LPRPALSLTNTANALSAVLASPLDVDTNAIEQALKTVKLAGRFDYREVH 308 Query: 294 SESPRVIFDVAHNPHAAEYLTGRM------------------KALPKNGRVLAVIGMLHD 335 +FDVAHN E+L ++ + + + + ML D Sbjct: 309 ERH--WLFDVAHNDQGVEFLLAQLVPLWQQHLTQQSTSEQVNQTSGEPATIKMLFSMLGD 366 Query: 336 KDIAGTLAWLKSV---VDDWYCAPLEGPRGATAEQLLEHLG------NGKSFDSVAQAWD 386 KDI + L + + DW+ A ++ PR AT E L L F + +A Sbjct: 367 KDINKVVQRLTTAGLPISDWFIAEIDYPRAATTEHLQGILASYVDDSQIHEFARLQEATH 426 Query: 387 AAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 A + ++ +D ++VCGSFHT+ + ++ R Sbjct: 427 AIINASQPQDLIVVCGSFHTIGEALSTLETR 457 >UniRef50_A5ZW55 Putative uncharacterized protein n=1 Tax=Ruminococcus obeum ATCC 29174 RepID=A5ZW55_9FIRM Length = 433 Score = 418 bits (1076), Expect = e-115, Method: Composition-based stats. Identities = 117/427 (27%), Positives = 181/427 (42%), Gaps = 27/427 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 ++Y+E T LE RLG + V VAGTNGKG+TC L S+ Sbjct: 3 YEEAVAYIEETPKFTTKNKLEHTKECLRRLGNPQKQFQVVHVAGTNGKGSTCAFLTSVFR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEY 126 AGY G+++SPHLV ER ++ + + +F +++ A G TYFE+ Sbjct: 63 EAGYSCGLFTSPHLVVINERFQINEKNIDNDTFLRAFEKVKKLADELVAEGSYHPTYFEF 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIG 185 L + +F A +D VILE GLGGRLDAT V + V+TSI+ DH +LG E+I Sbjct: 123 LFLMGMVIFADANVDYVILETGLGGRLDATTAVEEPSACVITSISFDHMQYLGNTIEAIA 182 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH----DWAFS 239 EKA I P I P I AQE G+ E + + D+++ Sbjct: 183 GEKAEIIVPGVPVIYDGNNPAAAGVIRARAQELGSPYFEVKREDTKIIRNTRAGIDFSYE 242 Query: 240 DAHGTLENLPLPLVPQPNAATALAALR-----ASGLEVSENAIRDGIASAILPGRFQIVS 294 + + LP + + + AL+ +++ A+R G+ GR + V Sbjct: 243 NEYYGNTVFTLPFIAEYQVMNSSLALKTIEVLKDQVKIPVEAVRKGLLETRWQGRMETVL 302 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD--DW 352 P VI D AHN E K+ + + + DKD + + + Sbjct: 303 --PGVIVDGAHNEDGVEKFVETAVHFQKDYPLTLLFSAVDDKDYTDMIRTILGKISFHHV 360 Query: 353 YCAPLEGPRGATAEQLLEH-----LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 + G R AE+L E ++ + V +A+ A+A + + GS + V Sbjct: 361 IVTQVGGYRKVPAEKLAEIFREKGCPTAEACEDVEEAFKKALAAKGEDGMLFCVGSLYLV 420 Query: 408 AHVMEVI 414 + +I Sbjct: 421 GEIKTLI 427 >UniRef50_C6D869 FolC bifunctional protein n=3 Tax=Bacillales RepID=C6D869_PAESJ Length = 458 Score = 417 bits (1074), Expect = e-115, Method: Composition-based stats. Identities = 119/433 (27%), Positives = 199/433 (45%), Gaps = 30/433 (6%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 + ++ L I GL+R+ + RL +AGTNGKG+TC L S+L Sbjct: 16 SYKEAVDWINGLIPFGIRPGLDRIEQLLERLNNPHRRLKFIHIAGTNGKGSTCAYLTSVL 75 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFE 125 M GY VG ++SP++ ++T R + GQ++ E ++S ++ S T FE Sbjct: 76 MKCGYDVGTFTSPYITKFTNRFQYNGQDIDEETLLRLSNVLKSHVEELAETEFGSPTMFE 135 Query: 126 YGTLSALWLFKQAQ-LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 T A+ + D V+ E GLGGR+D TNIV ++V+T++ DH D LG E++ Sbjct: 136 VSTALAILFYATVTYPDYVVWETGLGGRMDVTNIVTPIISVITNVGHDHMDRLGDTLEAV 195 Query: 185 GREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY-----SVTDHDWA 237 EKAGI ++ P + +PE+ + A EK + L G ++N + + Sbjct: 196 AFEKAGIIKAGVPVVSAVDQPEVVEVVKRTAAEKKSTLYLLGDQFNIKELSSEEDEQTFR 255 Query: 238 FSDAHGTLENLPLPL---VPQPNAATALAALRASG----LEVSENAIRDGIASAILPGRF 290 F +++ L + L + NAA A+ L L V ++A+ DG+ A PGR Sbjct: 256 FEGMFRSIDPLTITLNGAHQRTNAAVAVMTLEVLRQYYALIVEDDALADGLREAKWPGRL 315 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 ++VS SPR++ D AHNP AE L +++ + R+ ++ M+ +K+ L + +VD Sbjct: 316 EMVSRSPRILIDGAHNPEGAESLVQALRSTYRYDRLHVMMAMVENKNHRDVLKHILPIVD 375 Query: 351 DWYCAPLEGPRGATAEQLLEHLGNGKSFDS---------VAQAWDAAMADAKAEDTVLVC 401 + AE L + + + K +S + D +V Sbjct: 376 TLIVTEPDFRSKLDAELLADLVRDVKPAESSFELIVEKDWREGLRKLQQLTGETDLGVVT 435 Query: 402 GSFHTVAHVMEVI 414 G+ + + V I Sbjct: 436 GTLYLIGDVRSRI 448 >UniRef50_A9QPJ9 Folylpolyglutamate synthase n=1 Tax=Methylacidiphilum infernorum V4 RepID=A9QPJ9_METI4 Length = 441 Score = 417 bits (1074), Expect = e-115, Method: Composition-based stats. Identities = 123/422 (29%), Positives = 186/422 (44%), Gaps = 22/422 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L++L + LGL+ V +A +G +AGTNGKG+T + S L A+G Sbjct: 15 LNFLGQARKVGMKLGLQNVQRLAMEMGNPHENLNFIHIAGTNGKGSTAAFIASALQASGL 74 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE-------SARGDISLTYFEYGTL 129 K G++SSPHLV ER++V G+ + + + EI+ + D + T+FE + Sbjct: 75 KTGLFSSPHLVTIRERIQVNGKPITKIQFSRWVLEIQGKIQKIRQLKEDFTCTFFEIMAI 134 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +A+ F ++++D V+ E GLGGRLDATN V ++V+T+I DHT +LG E I EKA Sbjct: 135 AAILEFSRSKVDWVVWETGLGGRLDATNFVIPRLSVITNIDYDHTQFLGETLEEIAAEKA 194 Query: 190 GIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 GI + P +VG + A GA + + D+ Sbjct: 195 GIIKEGVPVVVGNLSHGALEVVKKCAARVGAPVVEVFRSVSLKSIKLDYKEHWVEIAGFP 254 Query: 248 LPLPLVPQPNAATALAALRASGLEVSENA------IRDGIASAILPGRFQIVSESPRVIF 301 L L A A + L S+ I+ G + PGRFQ++ E P I Sbjct: 255 FCLGLTGYHQLENAACAFVSLKLLFSKEDPLDIKSIQQGFRAVDWPGRFQLLWEKPLCIV 314 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D AHN A L + + + V G+L DK+ A LK + R Sbjct: 315 DGAHNVGAVVQLVANWEKIFGDEPYHLVFGVLKDKNFALMADVLKRKAQEVTLIKPPTVR 374 Query: 362 GATAEQLLEHLGNGKSFDSVAQAW-DAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSG 420 G ++L G+ K V W D ++ + +LV GS + + HV+ G Sbjct: 375 GLEPQKLFPFFGDVKL--RVCSCWSDFKLSLDRTSLPILVTGSLYLIGHVL----VEECG 428 Query: 421 GK 422 GK Sbjct: 429 GK 430 >UniRef50_B2A1F3 FolC bifunctional protein n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A1F3_NATTJ Length = 465 Score = 416 bits (1070), Expect = e-115, Method: Composition-based stats. Identities = 127/456 (27%), Positives = 205/456 (44%), Gaps = 53/456 (11%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 + +++NL GLER++ + L V VAGTNGKG+TC LES+L + Sbjct: 6 DEAIKWIQNLDKFGSKPGLERINWLLTELNHPHNHYPVIHVAGTNGKGSTCSILESLLSS 65 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE------SARGDISLTYFEYG 127 GY+VG+++SP + + ERV + + ++ EI+ A+G T FE Sbjct: 66 MGYQVGLFTSPFIDDFAERVTCNSKPITKTELGELVCEIKPIVEAAEAKGLGHPTQFEVI 125 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T AL F++ D+VILE GLGGRLDATN+V ++++TSI DH + LG I E Sbjct: 126 TALALLYFQKKSPDMVILETGLGGRLDATNVVTPVLSIITSIGYDHINVLGNTLTKIAEE 185 Query: 188 KAGIFRSEKPAIVG------------EPEMPSTIADVAQEKGALLQRRGVEWNYSV---- 231 KAGI + P I G + + S I + Q+KG+ L WNY + Sbjct: 186 KAGIIKENIPVITGLHQDKASIEEDTQEQAFSVIEEKCQKKGSPLYASERNWNYRIKAFS 245 Query: 232 -TDHDWAFSDAHGTLENLPLPLVPQ------PNAATALAALRASGL-EVSENAIRDGIAS 283 T + + + NL LPL+ + A AL L+ G E+ N +R G+ Sbjct: 246 STGYCFDYFGLEAEFINLKLPLLGESQIKNASMALCALELLKKQGWNEIDWNDMRKGMVR 305 Query: 284 AILPGRFQ--------------IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNG---RV 326 +P R + + P V+ D +HNP + + L ++ L N ++ Sbjct: 306 VNIPARMEFWPADSGEKTITGSRAEKQPDVLLDASHNPPSVQNLMSCIRRLDTNRKWNKI 365 Query: 327 LAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL------GNGKSFDS 380 + V G+L DK + +A + D+ + R +A LL+++ N Sbjct: 366 VFVTGVLQDKPMEKIVANFSLIPDEIVVTEPQNTRALSAHCLLDYITDQLPDTNISVESD 425 Query: 381 VAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 + +A ++ A +++ GSF+ V + Sbjct: 426 LYKAVRMGISKAGNGSLLVIFGSFYLVVEARRYLKT 461 >UniRef50_B3PFP2 Folylpolyglutamate synthetase n=1 Tax=Cellvibrio japonicus Ueda107 RepID=B3PFP2_CELJU Length = 430 Score = 416 bits (1070), Expect = e-114, Method: Composition-based stats. Identities = 178/419 (42%), Positives = 252/419 (60%), Gaps = 16/419 (3%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 LA+WL +LEN H + IDLGLER+ LVA R+G+L+P V TV GTNGKG+ ++ Sbjct: 4 DSLAAWLEWLENCHPREIDLGLERIRLVAGRMGLLQPTARVVTVGGTNGKGSCVTATAAL 63 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYF 124 L AAGY VGVY+SPHL Y ERV + G+ + + A SF I + ISLTYF Sbjct: 64 LRAAGYSVGVYTSPHLRVYNERVTIDGEPVDDQALCNSFERIYACCHANPPAEPISLTYF 123 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 EYGTL+AL +F+ +D ++LEVGLGGRLDA NI+DAD++V+TSI +DH DWLG +RE I Sbjct: 124 EYGTLAALDIFRARSVDAMVLEVGLGGRLDAVNILDADISVITSIDIDHKDWLGDNREDI 183 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-HDWAFSDAHG 243 G EKAGI+R+ +PAI + + P + + GA RG ++Y D + W +S + G Sbjct: 184 GFEKAGIYRAGRPAICADFDPPQRLLQAIIDLGAKGYLRGKHFDYHQEDTNHWRWSGSAG 243 Query: 244 TLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR-VIFD 302 E+ PLP +P P+ A AL A+ G+ V+ + +A +PGRFQ ++ R VI D Sbjct: 244 HFEHQPLPQLPLPSMAAALEAVTHLGVTVTPASFAL-LAELRVPGRFQHLAWQGRTVILD 302 Query: 303 VAHNPHAAEYLTGRM---KALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 VAHNP A +L + + RV A + M+ DKD G+LA L++++D W L+ Sbjct: 303 VAHNPAATLHLAKGLSDWRNTNPGARVFAAVAMMSDKDRPGSLANLQALMDGWLLVDLDI 362 Query: 360 PRGATAEQLLEHLGNGKSFD----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 PR A++EQL ++L + + A + + D ++V GSF TVA +EV+ Sbjct: 363 PRAASSEQLRKNLQDLGFEPLASGKMKACLQALLQVSVQGDLLVVFGSFFTVAAALEVL 421 >UniRef50_B8CY17 Folylpolyglutamate synthase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CY17_HALOH Length = 457 Score = 416 bits (1069), Expect = e-114, Method: Composition-based stats. Identities = 133/440 (30%), Positives = 218/440 (49%), Gaps = 46/440 (10%) Query: 18 SYLENLHSKTID----LGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 Y+ +L D GL+R++ + + V VAGTNGKG+T L+SI Sbjct: 5 KYINSLSRFGTDAGFKPGLDRINALLGSFNHPEDRLKVIHVAGTNGKGSTIAFLKSIYTE 64 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTYFEY 126 AGY+VGVY+SPHL+ + ER+ V + + + T +E+ D+ TYFE+ Sbjct: 65 AGYRVGVYTSPHLIHFNERIEVGNRAISTAELTDLVSELVPRVEDLKKDPEVGGPTYFEF 124 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIG 185 T AL F + +D+V+LEVGLGGRLDATN++ + V+V+TSI+LDHT LG D +SI Sbjct: 125 VTALALLYFARKDVDLVLLEVGLGGRLDATNVIKEPLVSVITSISLDHTSILGNDVKSIA 184 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-------- 235 REK+GI + + P + G E I + A+ K + L+ E++Y++ + Sbjct: 185 REKSGIIKRDCPVVTGVRNKEALRVIEETAKLKNSPLKIIDKEYSYNIIESSLEGQSFTV 244 Query: 236 WAFSDAHGTLEN--------------LPLPLVPQ-PNAATALAAL--RASGLEVSENAIR 278 + ++ +LE + LP V Q NA A+A + V+ I+ Sbjct: 245 FRLNNGDYSLEKEAESINGTEKIEYFIKLPGVYQVRNALLAMAVVDYLQEQYPVNLVQIK 304 Query: 279 DGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKAL-PKNGRVLAVIGMLHDKD 337 G+ASA +PGR ++++ SP +I D AHN + L + L ++ + ++G+L DKD Sbjct: 305 KGLASAFIPGRMEVLARSPLIIADGAHNVEGVKKLVNSLGPLINEDRQFYIIVGILGDKD 364 Query: 338 IAGTLAWL--KSVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMAD 391 + G + L + R + E + ++ + + + + + D Sbjct: 365 VEGMIEMLDFGKAKKELIITRNTNSRSCSPEVIGQYAQRRGIKYRVYPDLKTSLTGVLND 424 Query: 392 AKAEDTVLVCGSFHTVAHVM 411 A+ ED + V GS +TV+ Sbjct: 425 ARPEDVICVTGSLYTVSEAK 444 >UniRef50_Q1GD59 FolC bifunctional protein n=6 Tax=Alphaproteobacteria RepID=Q1GD59_SILST Length = 423 Score = 415 bits (1068), Expect = e-114, Method: Composition-based stats. Identities = 142/419 (33%), Positives = 199/419 (47%), Gaps = 25/419 (5%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESILM 72 + L+ + LH K IDL L+RV + A L + P V +AGTNGKG+T + + L Sbjct: 7 DAILARMMALHPKIIDLTLDRVWRLLAALENPQDKLPPVIHIAGTNGKGSTQAMIRAGLE 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 G V Y+SPHL R+ ER+R+ G + E+ T E SA GD S+TYFE T++ L Sbjct: 67 GWGKSVHAYTSPHLARFHERIRLAGDLISEAHLTEVLDECYSANGDASITYFEITTVAGL 126 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F + D +LEVGLGGRLDATN++ +V+V+T +++DH +LG I EKAGI Sbjct: 127 LAFSRTPADYTLLEVGLGGRLDATNVITPEVSVITPVSIDHEQFLGNTLAKIAGEKAGII 186 Query: 193 RSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 + P +VG E I D A GA L G W+ + D G L +LPL Sbjct: 187 KRGVPVVVGPQAEEAMEVIEDTAMRLGAPLIAYGQHWHVHEERGRLVYQDERGLL-DLPL 245 Query: 251 PLV----PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV------- 299 P + NA ALA LR G E A + A P R Q + P V Sbjct: 246 PNLMGAHQIQNAGAALAVLRHLGA--DEAACEAAVVGAQWPARMQRLKTGPLVEIAGAAE 303 Query: 300 -IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 D HN A L + LPK + GML+ KD+ G L L + + Sbjct: 304 LWLDGGHNAAAGIALADVLAKLPK-RPTHLICGMLNTKDVTGYLRPLAAEAQSLTAVSIP 362 Query: 359 GPRG-ATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 G +AE+ + + +SVA+A A +A + VL+CGS + +++ Sbjct: 363 GEAATLSAEETKAAASSVDLPATTAESVAEALTAILAR-DPDSRVLICGSLYLAGNILR 420 >UniRef50_A1HP48 FolC bifunctional protein n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HP48_9FIRM Length = 429 Score = 415 bits (1067), Expect = e-114, Method: Composition-based stats. Identities = 132/423 (31%), Positives = 205/423 (48%), Gaps = 20/423 (4%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L YL L+ I+LGL R+ + +G + V GTNGKG+T L +IL Sbjct: 2 TYQQALEYLATLNKFGINLGLARIKRLLDLMGHPERRYRTVHVTGTNGKGSTTAMLAAIL 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPES------AHTASFAEIESARGDISLTYFE 125 A+G K G+Y+SPHLV YTER+ V G+ + +T F E +A G T FE Sbjct: 62 QASGIKTGMYTSPHLVDYTERMVVDGRPAAPAAFAAAIDYTRRFIEQMTAEGWEHPTEFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T +A F +A+++ ++EVGLGG LD+TN++ + AV+T++AL+HTD G I Sbjct: 122 VLTAAAFHYFAEAKVEYAVIEVGLGGLLDSTNVISPEAAVITNVALEHTDRCGATVREIA 181 Query: 186 REKAGIFRSEKPAIV-GEPEMPSTIADVAQEKGALLQRRGVEW------NYSVTDHDWAF 238 R KAGI ++ P I E E + I + A G++L RG ++ Y Sbjct: 182 RHKAGIIKAGVPVITAAEGEALAVIREAAAACGSMLYVRGRDFVGEYLGRYDYGQRVAVH 241 Query: 239 SDAHGTLENLPLPLVPQPNA-ATALAALRAS-----GLEVSENAIRDGIASAILPGRFQI 292 + G L L L+ + A+A + A G ++ +A+ G+A+A PGRF++ Sbjct: 242 TAQTGRLGPFSLTLLGRHQVENCAIAVMTALVLAERGAPITPDALAAGLAAARWPGRFEV 301 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 P ++ D AHNPH A L + + + ++G+L DKDI G + L D Sbjct: 302 FPGEPVIVVDGAHNPHGARALRVALDEVFGGRPITFLLGILRDKDITGIVRALVRPQDMV 361 Query: 353 YCAPLEGPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 A R A ++ + G+ + S+A A A A+ V GS + + V Sbjct: 362 VAAAPLSERAAAPGEIAREIGGSVEEAPSIAAGLAQARRLAGADGVVCAAGSLYLIGAVR 421 Query: 412 EVI 414 +++ Sbjct: 422 QIL 424 >UniRef50_C8ZWR3 FolC family protein n=26 Tax=Enterococcus RepID=C8ZWR3_ENTGA Length = 446 Score = 414 bits (1066), Expect = e-114, Method: Composition-based stats. Identities = 104/438 (23%), Positives = 180/438 (41%), Gaps = 33/438 (7%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 + ++ + GL RV+ + G + +AGTNGKG+T L +L Sbjct: 6 DEAVRWIHSRKKFGSRPGLIRVNELLKLCGHPEKNSIGIHIAGTNGKGSTVTYLRCLLEM 65 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTYFEY 126 VG ++SP++ + ER+ + G+ + E + +T FE Sbjct: 66 QKLAVGTFTSPYIESFYERISINGKAISAEEFVQLANEFRPLVDSMDEDTRYQGITEFEI 125 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T A F Q D+ I E G+GG+ D+TN+ + +T+I LDHTD LG E I Sbjct: 126 LTAMAFSYF-QKHADIAIFEAGIGGKWDSTNVFIPILTAITTIGLDHTDILGETEEEIAL 184 Query: 187 EKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY--------------S 230 +KAGI + P + G I +VA +K A L ++ + S Sbjct: 185 QKAGIIKKNIPIVTGNISQNAVKIIEEVASKKNAPLSKKNTSYQVHYVKQSPESHSPKDS 244 Query: 231 VTDHDWAFSDAHGTLENLPLPLVPQPNAATALAAL-------RASGLEVSENAIRDGIAS 283 ++ + F + NL +PL + A AL + + + +I+ + Sbjct: 245 ISGEMFHFENEDFQFLNLRIPLCGKYQVENAATALQLFLLYCQQQNKAIQKESIQKALEK 304 Query: 284 AILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA 343 A PGR + +S P +I D AHNPHA + + + G+ + L K+ + Sbjct: 305 ARWPGRMEKISSQPTIIIDGAHNPHAIKEFVDTVTEKFQQGKKYILFSALTTKNSRKMIR 364 Query: 344 WLKSVVDD-WYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCG 402 ++ + ++ + P+ E L+ K + Q +A ++DT+ + G Sbjct: 365 QMQQIPNNCLIITTFDYPKALKKEDLVRENSQFKYYQEWQQGIKEIVAKMGSKDTLFITG 424 Query: 403 SFHTVAHVMEV-IDARRS 419 S + V+ V +D RR Sbjct: 425 SLYFVSQVRTYLLDDRRC 442 >UniRef50_UPI0001745D4D FolC bifunctional protein n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI0001745D4D Length = 413 Score = 414 bits (1066), Expect = e-114, Method: Composition-based stats. Identities = 125/410 (30%), Positives = 185/410 (45%), Gaps = 24/410 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L +L I LGLE + + + VAGTNGKG+ C L S+L AA Sbjct: 12 LDWLYGTQLFGIKLGLENTRKLLDDMKLPMGGQKFLHVAGTNGKGSVCAFLHSLLKAAEV 71 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSALWL 134 G+++SPHL+ + ER+R + + + D T+FE AL Sbjct: 72 NAGLFTSPHLIHFRERIRDAERTITSQEIVKEVDALRKRVEGWDPHPTFFELTFALALDW 131 Query: 135 FKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRS 194 F++ +L+ V+LE G+GGRLDATN V V+TSI+LDH LG I EKAGI + Sbjct: 132 FRKQELEWVVLETGMGGRLDATNTVLPAACVITSISLDHQQHLGATLREIATEKAGIIKP 191 Query: 195 EKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 P I PE+ ++D A+E+GA L + + H Sbjct: 192 GVPVITLKQAPEVMQVLSDTARERGAPLSIV----TTPLRGYQLGLFGQH---------- 237 Query: 253 VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEY 312 NA A+AA +A+G SE +R G+ + P RFQ + R+I D AHNP AAE Sbjct: 238 -QLWNATLAVAAFKAAGFRASEPVLRVGLKTVEWPARFQREEQD-RLIIDGAHNPDAAET 295 Query: 313 LTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL 372 L + V G + +KD + L+ + W+ + PR E L + L Sbjct: 296 LVRTWHQAFPGEKASVVFGAVSNKDAKAVMRSLQPIASHWHFTRFDSPRAMAPEDLRKEL 355 Query: 373 GNGKSFD---SVAQAWDAAMADAKAE-DTVLVCGSFHTVAHVMEVIDARR 418 + + SV + + A+A A+ + VLV GS + V+ ++ R Sbjct: 356 ADLYASAVNCSVHETIEDALAKARHNAERVLVTGSLYLAGEVISILRGER 405 >UniRef50_B0MBL9 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=B0MBL9_9FIRM Length = 425 Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats. Identities = 110/422 (26%), Positives = 185/422 (43%), Gaps = 23/422 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + + ++ + LGL+ + + RLG + + +AGTNGKG+T L S+ Sbjct: 3 YQATMEFIGRANKFGSILGLDNIRELLNRLGNPQDRLKIVHIAGTNGKGSTLAFLASVFK 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 GY+ G Y SP Y E+ R+ + + + +I+ ++ T FE Sbjct: 63 EQGYEAGRYVSPASFCYEEKFRINDEIITKEDLCFYMEKIKKTAEEMVRDGKEHPTVFEM 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIG 185 T + F ++D V+LE GLGGRLDATN++ + V+ SI DHT +LG + I Sbjct: 123 ETALSFLYFLDKKVDAVLLETGLGGRLDATNVIKHPICTVIASIGYDHTQYLGSTIQEIA 182 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVE----WNYSVTDHDWAFS 239 EKAGI + PA+ E I A+EK L + ++ +++ Sbjct: 183 GEKAGILKKGCPAVSYDNTSEAREVIEKAAEEKNVPLIFADTSRVTILSENLEGSVFSYV 242 Query: 240 DAHGT-LENLPLPLVPQPNAATALAALRASGLE-----VSENAIRDGIASAILPGRFQIV 293 A GT N+ + ++ + A AAL + +++IR G A GR Q + Sbjct: 243 CADGTEYRNMEIGMLGEHQIFNAAAALETIQILKKSYIFRQDSIRKGFKKARWDGRLQRI 302 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 S P D AHNP A+ L ++ N +++ ++G+L DKD L + S+ D+ Y Sbjct: 303 SAVPAAFCDGAHNPDGAQKLLQFLQKNFTNKKIIYIMGVLSDKDYPQMLEIMSSMSDEIY 362 Query: 354 CAPLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 EG R + L E S+ + + + +D ++V G+ + Sbjct: 363 TVTPEGDRALPSGVLAEAARPFYRKVTEGGSLGECYQQVKKECGQDDVIVVFGTLSFLKE 422 Query: 410 VM 411 + Sbjct: 423 LR 424 >UniRef50_C6VI65 Folylpolyglutamate synthase n=8 Tax=Bacilli RepID=C6VI65_LACPJ Length = 444 Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats. Identities = 114/435 (26%), Positives = 189/435 (43%), Gaps = 29/435 (6%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 ++ L+++ L R+ LG + VAGTNGKG+T L + Sbjct: 3 DTYSAALAFIHGRTQFKKAPTLSRMRQFLHELGDPQLKVAGIHVAGTNGKGSTVANLREL 62 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTY 123 MA G VG ++SP +VR+ ER+ V G + + +I+ + T Sbjct: 63 FMADGLTVGTFTSPFIVRFNERISVDGTPISDEELVGLVQQIQPIVAKLDATLASGGPTE 122 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T F +D+ I+EVGLGG D+TN+ V+V+T+I DH LG + Sbjct: 123 FEIITAMMFLYFAAQPIDIAIIEVGLGGLYDSTNVWTPAVSVITTIGYDHMQILGNTLTA 182 Query: 184 IGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT-----DHDW 236 I +KAGI +++ P IVG E + D A K A L+ GV++ + + Sbjct: 183 IATQKAGIIKTQVPVIVGKLPAEAQQVMIDTAMSKRAPLRTLGVDFTTKLLPPQGWQERF 242 Query: 237 AFSDAHGTLENLPLPLV---PQPNAATALAAL----RASGLEVSENAIRDGIASAILPGR 289 F ++L PL+ NAA A+AA +A+ L V + ++ +A+ PGR Sbjct: 243 NFDGLEAHFKDLTTPLLGDYQVDNAAVAIAAYLTYHQATQLPVVTSDVKAAVAATQWPGR 302 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 F+ +++ P ++ D AHN A L + V + +L DK + L ++ Sbjct: 303 FERLNQDPLIMIDGAHNEPAVTELAATLSERFGQQTVYVIFAVLADKQHQQMIQTLGALP 362 Query: 350 D-DWYCAPLEGPRGATAEQ----LLEHLGNGKS---FDSVAQAWDAAMADAKAEDTVLVC 401 + EGP L + NG++ FD+ A + + ++D +L+ Sbjct: 363 NVQLRLTQFEGPNAKRPATDPTMLAHEMPNGRTAEVFDNWQAALMQTLQEMSSDDALLLT 422 Query: 402 GSFHTVAHVMEVIDA 416 GS + ++ V Sbjct: 423 GSLYFISDVRAYFKD 437 >UniRef50_D2QCN6 FolC bifunctional protein n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QCN6_9SPHI Length = 428 Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats. Identities = 132/424 (31%), Positives = 201/424 (47%), Gaps = 24/424 (5%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 +A L S L + K I GL L+ LG VAGTNGKG+T L Sbjct: 5 EAIDYLYSRLPVFHRIGPKAIKPGLGNTLLLCEGLGNPHQQFTSIHVAGTNGKGSTSHML 64 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 +I +AGY+VG+Y+SPHL +TER+R+ G+ +PE + + + ++FE Sbjct: 65 AAIYQSAGYRVGLYTSPHLKSFTERIRLNGRPIPEEEVVRFVEQQQPLIESVEPSFFEVT 124 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 A + F + +D+ I+EVGLGGRLD+TN++ +V+T+I DHTD LG I E Sbjct: 125 VAMAFYFFARHAVDIAIIEVGLGGRLDSTNVITPIASVITNIGYDHTDILGDTLPLIAAE 184 Query: 188 KAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYS-------VTDHDWAF 238 KAGI + P I+GE PE V+ A + ++ + + + Sbjct: 185 KAGIIKPGVPVIIGESHPETQEVFTSVSASLQAPITFADRQYLVNDLGLVDGIRQASISR 244 Query: 239 SDAHGTLENLPLPLVPQ----PNAATALAALRASGLEVSENAIRDGIASAI----LPGRF 290 D G L L L Q P + L+ V+ ++G+AS L GRF Sbjct: 245 GDGSGWLAQLDLLGAYQLKNLPGVFATVEQLQQQ-FPVTAAQQQEGLASVSLLTGLKGRF 303 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 Q + PRVI D AHN E L ++++P + +IG++ DKD + L+ L + Sbjct: 304 QTLGSHPRVIADTAHNQPGLEALFDTIRSIP-YKTLRIIIGLVADKDRSKVLSVLPTNAV 362 Query: 351 DWYCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 ++C PR +A+ L + G F V A AA+ A +D +L+ GS +T Sbjct: 363 YYFC-QANTPRSLSAQLLQQEARVLGRIGDVFTDVNTALAAALEQADPDDLLLITGSNYT 421 Query: 407 VAHV 410 +A + Sbjct: 422 IAEL 425 >UniRef50_B4CZE0 FolC bifunctional protein n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4CZE0_9BACT Length = 408 Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats. Identities = 130/418 (31%), Positives = 197/418 (47%), Gaps = 33/418 (7%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVL---KPAPFVFTVAGTNGKGTTCRTLESIL 71 + +L I LGLE + + L + AP +AGTNGKG+ C L++ Sbjct: 5 EAVDWLYASQLHGIKLGLENIQRLVETLKIDVAGPRAPKFLHIAGTNGKGSVCAMLDACC 64 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE--SARGDISLTYFEYGTL 129 AAG + G+++SPHL+ + ER+R+ G+ + E+ +I + D T+FE T Sbjct: 65 RAAGLRTGLFTSPHLITFRERIRLDGEMISEAEVAEGLTKIRTLAENWDHEPTFFEITTA 124 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 AL F+ ++V+LE G+GGRLDATN+V V+T I LDH WLG +I REKA Sbjct: 125 LALAWFQAKGAEIVVLETGMGGRLDATNVVSPVACVLTPIDLDHQQWLGESLGAIAREKA 184 Query: 190 GIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 GI + PA+ E+ + A+VA EK L+ + ++ A + +H Sbjct: 185 GILKQGVPAVSAPQADEVGAVFAEVATEKQVALEYIPT----PLAGYEVALAGSH----- 235 Query: 248 LPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNP 307 NAA A+ AL +GL VSE AI G+ PGRFQ V R I D AHNP Sbjct: 236 ------QMWNAALAVRALSLAGLPVSEEAIVRGLREVSWPGRFQHVQS--RFIIDGAHNP 287 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQ 367 AA L + + + R ++G+L DKD+ G L + P+ PR AT+ + Sbjct: 288 AAARRLATTWREVFGDKRASLILGVLRDKDVNGICEALLPIAGRILTVPVNNPRSATSME 347 Query: 368 LLEHLG------NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 + +G + A A + + L+ GS + ++A+ + Sbjct: 348 VARAIGKIAPRLECIVVRDLPAAIRIAQSMERK---TLITGSLFLAGEALAFLEAQPA 402 >UniRef50_D1PA28 Tetrahydrofolate synthase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PA28_9BACT Length = 412 Score = 414 bits (1064), Expect = e-114, Method: Composition-based stats. Identities = 117/404 (28%), Positives = 202/404 (50%), Gaps = 26/404 (6%) Query: 21 ENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGV 80 E + +K GL+ + + G +AGTNGKG++ TL +IL + GYKVG+ Sbjct: 18 EKIGAKAYKPGLDTMYKMDEHFGHPHNQYKCIHIAGTNGKGSSSHTLAAILQSQGYKVGL 77 Query: 81 YSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQL 140 ++SPHLV + ER+R+ G+ + E + ++FE T+ A F + ++ Sbjct: 78 FTSPHLVDFRERIRINGEMVSEEYVIDFVENNRKFFEPLHPSFFELTTMMAFQYFAEQKV 137 Query: 141 DVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV 200 D ++EVGLGGRLD+TNI+ ++V+T+I+ DHT +LG I EKAGI + + P ++ Sbjct: 138 DFAVIEVGLGGRLDSTNIITPILSVITNISFDHTQFLGNTLGEIAGEKAGIIKPKIPVVI 197 Query: 201 GE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNA 258 GE E A E+ + + TD D F G + + Sbjct: 198 GEWNEETQPVFIKKAHEQNSPIHFAHE------TDADMNFE-LKGNYQKKNFCTI----- 245 Query: 259 ATALAALRASGLEVSENAIRDGIASAI----LPGRFQIVSESPRVIFDVAHNPHAAEYLT 314 + A+ L+ G+E+ + +I++G L GR++ ++E P I D HN EYL Sbjct: 246 SAAVECLKEEGIEIKDQSIKNGFEHVCELTGLRGRWEKLNEHPLTICDTGHNLAGWEYLE 305 Query: 315 GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD---WYCAPLEGPRGATAEQLL-- 369 ++ ++ + + V GM+ DKD+ + L+ + + +Y R ++L Sbjct: 306 PQIASVKADTK-HIVFGMVDDKDVEHVMELLEKLPKESTIFYWTQPSTKRAIPVDKLFGY 364 Query: 370 --EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 +H NG + ++AQA++ A A+AK +D + + GS + VA ++ Sbjct: 365 AQKHGLNGTCYQTIAQAFNTAKANAKKDDFIFIGGSSYVVADLL 408 >UniRef50_Q03EP1 Folylpolyglutamate synthase n=2 Tax=Pediococcus RepID=Q03EP1_PEDPA Length = 424 Score = 414 bits (1064), Expect = e-114, Method: Composition-based stats. Identities = 104/423 (24%), Positives = 189/423 (44%), Gaps = 22/423 (5%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 + L ++ + ++R++ +LG + A VAGTNGKG+T L ++ Sbjct: 2 DYKTALKFIHGRPRLRKEPTVKRMTAFLDQLGNPQDAIQGIHVAGTNGKGSTIAFLAKMM 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT------YFE 125 G +VG ++SP+L R+ ER+ V G + + EI+ ++ T FE Sbjct: 62 ETTGQRVGTFTSPYLERFNERIAVNGIPIRDDEILTLVEEIKPIVDELDQTPLGGPLEFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T FK+ +D+V++EVG+GGR D+TN+ +V+T+I DH LG I Sbjct: 122 IVTAMMFLYFKKHPVDIVLIEVGIGGRYDSTNVFTPIASVITNIGWDHMQILGDTLPKIA 181 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 +KAGI ++ P I G + I + A++ A L+ ++ ++ FS+ Sbjct: 182 FQKAGIIKTNVPVITGTEDQAALRVIEEEAKKLHAPLKILKRDFKIDSKEN--FFSNTFA 239 Query: 244 TLENLP---LPLVPQPNAATALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSES 296 +E++ L L N A AL + R +++ + +R + GR +I+ + Sbjct: 240 QIEHIHSGLLGLYQVNNLAVALETMLVVSRQLNWKINYDQLRQAVQHTQWAGRMEIIQKR 299 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD-DWYCA 355 P++I D AHN + L ++A +V + +L DK L L + + Sbjct: 300 PKIILDGAHNLPGIQALKKSIQAYWPEQKVFILAAILDDKRFEAMLTELVDLKQVELTLT 359 Query: 356 PLEGP--RGA-TAEQLLEHLGNGKSFD-SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 GP R A +L + + ++ + A + AK D +++ GS + ++ V Sbjct: 360 RFNGPIKRAAVDWSELHDPIRKDINYQANWQLALKEILRQAKPSDVIIITGSLYFISEVR 419 Query: 412 EVI 414 + Sbjct: 420 PQL 422 >UniRef50_D1PK55 Tetrahydrofolate synthase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PK55_9FIRM Length = 432 Score = 414 bits (1064), Expect = e-114, Method: Composition-based stats. Identities = 123/426 (28%), Positives = 186/426 (43%), Gaps = 22/426 (5%) Query: 14 ASWLSYLENLHSKTI-DLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + L L GLER+ + A LG + + +AGTNGKG+ +IL Sbjct: 4 QQAMEALHALPRLGSGKPGLERMKNLLAHLGNPEESLQCVHIAGTNGKGSLAAMTAAILT 63 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEY 126 AAGYK G+ SP++V + ER ++ G+ +P + ++ A G FE Sbjct: 64 AAGYKTGLTISPYVVDFRERFQIDGEMIPPRTLASLTQKVLGAIEAIRQEGGEEPVQFEA 123 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIG 185 T AL F + + D+V+LE GLGGR DATN V VA +T I DH + LG + I Sbjct: 124 VTALALLWFAREKCDLVVLETGLGGRYDATNAVPHTLVAAITKIGYDHMELLGDTLDKIA 183 Query: 186 REKAGIFRSEKPAIV---GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 EKAGI + + E I A E + +E + + Sbjct: 184 AEKAGIIKEGCAVVCYPDQPAEAMGPILTAAAEAHTSIITPELEDIRQLPGKTLENRIDY 243 Query: 243 GTLE-NLPLPLVPQPNAAT-----ALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 G + +L P Q N A ALA R G E+S++AI G+A+A +P R +++ Sbjct: 244 GGYQASLAFPGAHQANHAAMAVEIALALWREYGYEISDDAILQGLAAARMPARIEVLRRH 303 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P ++ D HNP L ++ ++ V+GML DKD L L Y Sbjct: 304 PLLLLDGCHNPDGTRALAETLQKAKYEENLVGVLGMLADKDYQKMLEILAPCFAKVYTVT 363 Query: 357 LEGPRGATAEQLLEHLG---NGKSFDSVAQAWDAAMADAKAEDT--VLVCGSFHTVAHVM 411 PR + E L + + ++ +V +A AA+ A+ + V+VCGS + A Sbjct: 364 PNCPRALSGEDLQKAARFHMDAEAAATVPEALRAAVRYAEDHNLAGVVVCGSLYLAAEAR 423 Query: 412 EVIDAR 417 + Sbjct: 424 PWLLKE 429 >UniRef50_C2ETR7 Tetrahydrofolate synthase n=3 Tax=Lactobacillus RepID=C2ETR7_9LACO Length = 441 Score = 414 bits (1064), Expect = e-114, Method: Composition-based stats. Identities = 105/437 (24%), Positives = 184/437 (42%), Gaps = 29/437 (6%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + A L+++ L+R+ L RLG + + GTNGKG+T L Sbjct: 5 EMIESYAEALNFIHGRTKFKKIPTLDRMRLFLDRLGNPQKGLKYVHITGTNGKGSTVAML 64 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------- 120 S+LM AG VG ++SP + R+ ER+ + + + + T ++E + Sbjct: 65 RSMLMKAGLNVGSFTSPFITRFNERIALNAEPISDEDLTRLARKVEPVVQQLDQELPTGG 124 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 T FE T F + Q D+V+LEVG+GG D+TN++ V+V+T+++ DH +LG Sbjct: 125 PTEFEIDTAIMFCYFAEKQPDLVLLEVGIGGLYDSTNVITPLVSVITTVSWDHMKYLGDT 184 Query: 181 RESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDH---- 234 I +KAGI + P ++G+ I A EK A + G +++ + Sbjct: 185 LAKIAHQKAGIIKKGVPVVIGQLPSSARQVIMREANEKSAKVYELGKDFSAQKINRNAIK 244 Query: 235 -DWAFSDAHGTLENLPLPL---VPQPNAATALAA----LRASGLEVSENAIRDGIASAIL 286 + + L L NAA A+ L G+ V ++ G+ Sbjct: 245 AEIVYDGDQLHHFRSNLGLAGDYQVENAAIAITTVQIVLTKLGIPVITGDLKKGLEMTRW 304 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 PGR + + P V+ D AHN + L ++ + V ++ +L DK L L Sbjct: 305 PGRMETIISEPLVLLDGAHNLPGMQALVKTIRDDFSDREVYVLVAILADKQYELMLGELA 364 Query: 347 SVVD-DWYCAPLEGP-RGATAEQLLEHLGNGKS------FDSVAQAWDAAMADAKAEDTV 398 S+ + GP + L +G K+ ++ + + A+D + Sbjct: 365 SLGNVHLMVTNFAGPGPKRPSADLATTIGEFKTKYPIQVAENWQTGFVKLSQELAADDVM 424 Query: 399 LVCGSFHTVAHVMEVID 415 ++ GS + V+ V + + Sbjct: 425 IITGSLYFVSEVRKNLK 441 >UniRef50_D0MEF9 FolC bifunctional protein n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MEF9_RHOM4 Length = 442 Score = 413 bits (1063), Expect = e-114, Method: Composition-based stats. Identities = 143/428 (33%), Positives = 204/428 (47%), Gaps = 28/428 (6%) Query: 15 SWLSYLENLHSKT------IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 L+YL +L T GLER+ + A +G A +AGTNGKG+T L Sbjct: 2 DALNYLLSLPRFTDQGRAAYRPGLERMGALLAAMGAPHRAYPCVHIAGTNGKGSTASLLA 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 +I AAGY+VG+++SPHL ER+R+ G P + + A + ++FE Sbjct: 62 AIARAAGYRVGLHTSPHLWHVGERMRIDGIPAPTTWLEKAVARCRPLFEQVQPSFFEATV 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 + F + Q+D+ ++EVGLGGRLDATN+V +AV+TSI LDHTD LG E+I REK Sbjct: 122 ALSFLYFAEQQVDLAVVEVGLGGRLDATNVVQPRLAVITSIGLDHTDILGETIEAITREK 181 Query: 189 AGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF-----SDA 241 AGI + P + G +PE + I + A + A L E + + F Sbjct: 182 AGIIKPGVPVLTGVTQPEALAVIRETAARQQAPLHYLWEEVHLEQVAPETVFMRLTARTP 241 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSE-----NAIRDGIASAI----LPGRFQI 292 E+L + L + AA AL A+RA+ L + E IR G+ L GRF + Sbjct: 242 ARRYEDLEVGLPGRHQAANALLAIRAAELVLPEVLDDPRPIRQGLRDVRQLSGLRGRFDV 301 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKN--GRVLAVIGMLHDKDIAGTLAWLKSVVD 350 + P V+ DVAHNP + + AL GR A+ L DKD L Sbjct: 302 LQTRPLVVADVAHNPDGLAAVLTTIDALHPPGTGRRYAIWSALRDKDAPTMAGQLVQAGF 361 Query: 351 DWYCAPLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 Y A LE PR +A +L+ + G +VA W +A+D +L+ GS Sbjct: 362 SVYVAALESPRAWSAVELVAMVQQVGGQVPGVGTVASGWQLLQKRLQADDVLLITGSHQV 421 Query: 407 VAHVMEVI 414 VA + V+ Sbjct: 422 VAALPPVL 429 >UniRef50_UPI0001C42143 folyl-polyglutamate synthetase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C42143 Length = 442 Score = 413 bits (1063), Expect = e-114, Method: Composition-based stats. Identities = 114/430 (26%), Positives = 208/430 (48%), Gaps = 23/430 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + + ++ +L I GL+R+ + ARLG + + GTNGKG+T L +L Sbjct: 4 VEEAIEWIHSLLPFGIKPGLKRMEWMLARLGHPERELKTIHIGGTNGKGSTVSYLRHMLE 63 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 A+ YKVG ++SP++ + ER+ V G+ +P ++++ ++ S T FE Sbjct: 64 ASSYKVGTFTSPYIECFEERISVNGEPIPGDDLLECASKVKPLVEELEKTELGSPTEFEV 123 Query: 127 GTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T F ++ D V++EVGLGGRLD+TN++D ++++TSI DH LG E I Sbjct: 124 ITTIGFLYFATVSKPDFVLVEVGLGGRLDSTNVIDPLLSIITSIGHDHMHILGDSLEDIA 183 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSV-----TDHDWAF 238 EKAGI + KP I G +PE + + A E+ A L++ ++ + ++F Sbjct: 184 FEKAGIIKYGKPVISGVSQPEAKQVLKEKAAEEKAALKQLNEDFEQVLITRNAASQMFSF 243 Query: 239 SDAHGTLENLPLPL---VPQPNAATALAALRASG----LEVSENAIRDGIASAILPGRFQ 291 + + + + + NAA AL A+ G +E+ + + G+ +A GRF+ Sbjct: 244 YSQRLSFDTCTIQMAGKHQRNNAALALEAMITLGELGIIELDTDLVLKGLKNASWAGRFE 303 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 +V++ P +I D AHN L + + + V+ +KD+ LA +++ D Sbjct: 304 VVNKEPVIILDGAHNEEGMSALAETLTSHYPDKHYKLVMAATKEKDMKKLLAPFETMDAD 363 Query: 352 WYCAPLEGPRGATAEQLLEH--LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 + + R A+ +L E + + + S ++A A+ + + ++V GS + V+ Sbjct: 364 FTFTTFDFFRAASERELYEQALVPHKRMSISWSEAIKDAVGNINDNEIIIVSGSLYFVSD 423 Query: 410 VMEVIDARRS 419 V + + Sbjct: 424 VRRWLKESPA 433 >UniRef50_A4A847 Folylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=unclassified Gammaproteobacteria RepID=A4A847_9GAMM Length = 428 Score = 413 bits (1063), Expect = e-114, Method: Composition-based stats. Identities = 160/413 (38%), Positives = 231/413 (55%), Gaps = 9/413 (2%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L WL YLE LH IDLGL RV A +L + P V TVAGTNGKG+ E IL Sbjct: 5 SLGEWLRYLEQLHPVDIDLGLARVRKAAEQLALFPYGPEVITVAGTNGKGSVVFGTECIL 64 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 A G + G Y+SPHL+ + ER+ V G + + A+F IE+ARGD++LTYFE+ TL+A Sbjct: 65 RAHGRRTGRYTSPHLLSFNERIAVDGCPVSDGQIVAAFDAIEAARGDVTLTYFEFATLAA 124 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 W+F++ ++DV ++EVGLGGRLDA N+VD+D+AV+T+I LDH WLG E I EKA I Sbjct: 125 YWIFRELRVDVAVMEVGLGGRLDAVNLVDSDIAVITAIDLDHQHWLGDTVEQIAPEKAAI 184 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLP 251 R +P ++ E + P T+ + GA+ R G EW++ H +PLP Sbjct: 185 ARPGRPVVLAEADYPDTLFHTLDDIGAVPLRAGREWSWRYEGDLQLSLKDHRESITVPLP 244 Query: 252 --LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR-VIFDVAHNPH 308 L P A A+ + G R+ + + +P R Q +S + R ++ DVAHNP Sbjct: 245 DGLRPSNLGAALQASAVSLGQTFDPQKSREALRTLSVPARRQTISFAGRALLLDVAHNPA 304 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-PRGATAEQ 367 A L +KA P G+ A +G++ DKD+AG A L + VD + G R A E Sbjct: 305 AMVALVEHLKARPVPGKTFAALGLMKDKDLAGMAASLATAVDGACALAIPGIDRAAAPEA 364 Query: 368 LLEHLGNGKSF----DSVAQA-WDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + + L + + A A W + + A D +++CGSF++VA +ME+++ Sbjct: 365 VWQALDDVGIAIPQGEFTADAVWSQLLDGSAAGDRLVICGSFYSVAGIMELLN 417 >UniRef50_A8RF48 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM 3991 RepID=A8RF48_9FIRM Length = 405 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 117/409 (28%), Positives = 189/409 (46%), Gaps = 14/409 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + ++ +E ++ GL +G V GTNGKG+T + +IL Sbjct: 5 VDELIAEIEGRKNRG--YGLSHFQAYMESIGNPHLDLCAIHVGGTNGKGSTTNYVRAILQ 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AAGY+VG ++SP+L+ + +R+R+ E+ E+ + ++ + L+ FE A Sbjct: 63 AAGYRVGSFTSPYLITHRDRIRINDIEISEADFLKIANDYYASWIEWDLSMFEIDMCIAS 122 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 FKQ ++D + EVGLGGRLDATN++ ++V+T+I +DH++ LG +I +EKAGI Sbjct: 123 VYFKQQKVDYCVFEVGLGGRLDATNVLQPLLSVITNIGMDHSELLGDSYTAIAKEKAGII 182 Query: 193 RSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS-DAHGTLENLP 249 + P + E E S A++A+EK + + N + F H ++ Sbjct: 183 KEGIPLVTAEKKAECCSVFAEIAKEKHSEVHVLKPIENRRCENLHILFDYGDHKQIKLAT 242 Query: 250 LPLVPQPNAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNP 307 NAA A+ A L L +SE +R +A+ GRF+IV + P VI D AHN Sbjct: 243 AADYQCENAALAIEAVSLLHGRLHISEEILRQALAATQWKGRFEIVQKEPLVILDGAHNV 302 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQ 367 E L + + + V +L DK+ L L + D L R ++ Sbjct: 303 EGIEALCDSLDNIH---NPVIVFSVLKDKNFTVMLEKLMGITDTMIVTKLHHERAYDMDR 359 Query: 368 LLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 L + DS A A A +A V++ GS + ++ V A Sbjct: 360 LAQQYDVCYIEDS-KTAIQQACAMKRA---VVITGSLYFISEVRAYFKA 404 >UniRef50_C0CPE6 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0CPE6_9FIRM Length = 448 Score = 412 bits (1060), Expect = e-113, Method: Composition-based stats. Identities = 110/430 (25%), Positives = 181/430 (42%), Gaps = 28/430 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 ++Y++ T LE RLG + A V VAGTNGKG+TC L S+L Sbjct: 19 YNEAVAYIDETPKFTTKNSLEHTRECLRRLGNPQEAFRVIHVAGTNGKGSTCAFLTSMLR 78 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEY 126 AGY G+++SPHL+ ER ++ + A+F ++ A+G TYFE Sbjct: 79 EAGYSCGLFTSPHLIEINERFQINEVPVDNEIFLAAFHRVKEMADELVAQGSHHPTYFEM 138 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIG 185 L + +FK+A +D V LE GLGGRLDAT ++ V+TSI++DH ++LG E I Sbjct: 139 LFLMGMLIFKEAGVDYVTLETGLGGRLDATTSIENPMACVITSISMDHMEYLGNSLEEIA 198 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH----DWAFS 239 EKAGI P I + AQE G+ + + D++ Sbjct: 199 SEKAGIIVPGVPVIFDGNHGAAAEVVRKKAQELGSPFYEVCEADCEILRNTRDGIDFSMK 258 Query: 240 DAHGTLENLPLPLVPQPNAATALAALRA-----SGLEVSENAIRDGIASAILPGRFQIVS 294 + + +P V + A AL+ + ++ G+A GR + V Sbjct: 259 NGYYEKNIFSIPFVARYQVMNAALALKTMEVMREQFSFTTRQLQMGMAQTRWQGRMETVL 318 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS--VVDDW 352 P VI D AHN + + ++ + + DKD + + +D Sbjct: 319 --PGVIVDGAHNEDGVFRFVETARYFQEESKITLLFSAVSDKDYKDMIRTICQGIHLDQV 376 Query: 353 YCAPLEGPRGATAEQLLEH-----LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 ++G R A++L + + + + +A+ A + + + GS + V Sbjct: 377 VTTQIDGYRVVPAQELAQLFRDCGCSDVIAEPEIPKAFVQARKK-QGDGLLFCVGSLYLV 435 Query: 408 AHVMEVIDAR 417 + + I + Sbjct: 436 GEIKDEIRRQ 445 >UniRef50_C6Y3V5 FolC bifunctional protein n=4 Tax=Sphingobacteriales RepID=C6Y3V5_PEDHD Length = 428 Score = 412 bits (1059), Expect = e-113, Method: Composition-based stats. Identities = 127/429 (29%), Positives = 202/429 (47%), Gaps = 24/429 (5%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 Q L S L + + L L+ A+L + V GTNGKG+T Sbjct: 2 NYKQTIDYLYSRLPMFTRVGAVAFKKDLHNTILMCAQLDNPQNKFKTIHVGGTNGKGSTS 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 TL +I AGYK G+Y+SPHL + ER+R+ G +PE+ T + IS ++F Sbjct: 62 HTLAAIFQQAGYKTGLYTSPHLKDFRERIRINGTMVPETFVTDFVNRQKETIEAISPSFF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E A F + ++D+ I+EVGLGGRLD+TNI+ +++V+T+I+LDHT+ LG I Sbjct: 122 EVTVAMAFAYFAEEKVDIAIIEVGLGGRLDSTNIITPELSVITNISLDHTNMLGNTLTEI 181 Query: 185 GREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF---- 238 EKAGI + P ++G + E + A + + E + + T + + Sbjct: 182 ATEKAGIIKPGIPVVIGEKQTESEAVFLTKASTTNSKIVFADQELSTTNTFREKEYLVTS 241 Query: 239 --SDAHGTLENLPLPLVPQPNAATALAALRA------SGLEVSENAIRDGIASAI----L 286 + ++L L L L L+A G +++ A+ + + L Sbjct: 242 ILKNKILIYKDLQLDLNGIYQLKNILTVLQAVDILKNKGYTLNDKALYTALKNVKTLTGL 301 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 GR+Q +SE P VI D HN + + +K ++ VIGM+ DKDI+G L L Sbjct: 302 QGRWQKLSEHPLVICDTGHNMAGIKEVVQNLKE-TPFEKLHIVIGMVKDKDISGVLTLLP 360 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCG 402 + ++C + R A++L +G FD+V A +AA +A +D + + G Sbjct: 361 TEAIYYFC-QPQLERALPAQELALQAKVQQLHGNVFDTVTAALNAAKENAGKDDLIFIGG 419 Query: 403 SFHTVAHVM 411 S VA V+ Sbjct: 420 SNFVVAEVL 428 >UniRef50_Q0AWF7 Putative uncharacterized protein n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AWF7_SYNWW Length = 416 Score = 412 bits (1059), Expect = e-113, Method: Composition-based stats. Identities = 120/411 (29%), Positives = 188/411 (45%), Gaps = 21/411 (5%) Query: 25 SKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSP 84 S I GL R+ + +G + +AGTNGKG+T L ++L AGY+VG + SP Sbjct: 3 SSGIKPGLSRIEALLREMGHPEKCLKTVHIAGTNGKGSTSFILSAVLSQAGYRVGRFISP 62 Query: 85 HLVRYTERVRVQGQELPESAHTASFAEIESARGDIS--LTYFEYGTLSALWLFKQAQLDV 142 H+ Y ER + + E A+++ ++S T FE T AL F+ Q+D+ Sbjct: 63 HIHSYRERFTINDTFIEEEEFLFYMAQVKKHIKNLSQRPTEFEILTAIALEYFRDKQVDL 122 Query: 143 VILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE 202 I EVG+GG D+TN+++ V+V+T I DHT +LG E I R KAGI + + P ++G Sbjct: 123 AIFEVGMGGIYDSTNVIEPVVSVITGIDYDHTQYLGTSLEEIARNKAGIIKKKVPLVMGP 182 Query: 203 --PEMPSTIADVAQEKGALLQ-----RRGVEWNYSVTDHDWAFSDAHGTLENLPLP---- 251 P IA A+E + L E S+ + ++ + LP Sbjct: 183 VNPPARQVIAARARELDSPLYPSSLAEVTREAQASLEGQLLKLVFSGQVVDKVFLPSPAS 242 Query: 252 --LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHA 309 L A TAL L+ +G +E ++ +A +PGR +IV +P I D AHNP A Sbjct: 243 YQLENLAVAFTALQVLKMAGFLWTEGDMKAALAKLRIPGRMEIVRINPPFILDAAHNPQA 302 Query: 310 AEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLL 369 A L + + + V+G+L DKD L L + EG R ++L Sbjct: 303 ASVLASSLNDILPGKKKALVLGVLDDKDAQNILKPLGHNTRVLVLSRPEGSRSKNWKRLK 362 Query: 370 EHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 E + + + +A + K D +L+ GSF+ + + + Sbjct: 363 EDWLSLFPGADLYMEEDIIEAIKVGESLLKLGDYLLITGSFYLLDKARKYL 413 >UniRef50_A8F8Q4 FolC bifunctional protein n=1 Tax=Thermotoga lettingae TMO RepID=A8F8Q4_THELT Length = 441 Score = 410 bits (1056), Expect = e-113, Method: Composition-based stats. Identities = 119/429 (27%), Positives = 205/429 (47%), Gaps = 31/429 (7%) Query: 15 SWLSYLENLHSK----TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 ++L LE L+ + I LGL+R+ + RLG + +AGTNGKG+ R L + Sbjct: 2 TYLKMLEYLYKERPSGKITLGLDRIQKLCERLGNPQNVFKSAHIAGTNGKGSVTRFLSWL 61 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTY 123 + G K Y SPHL + ER+ V + + + +F E++ A ++ ++ Sbjct: 62 FIEHGLKTAAYYSPHLTSFKERILVDEKFITDETMLNAFHEVQQAAIELDKEGEQSKPSF 121 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE+ T A +++ + +EVGLGGR DATN++ +V+V+ ++ DH LG E Sbjct: 122 FEFTTAMAFCVYRDMKTQAASIEVGLGGRFDATNVLTPEVSVIVTVGFDHMHILGNTLEK 181 Query: 184 IGREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYS-----VTDHDW 236 I EKAGI + P + GE + I VA K + + G ++ Y ++++ + Sbjct: 182 IAFEKAGIIKENIPVVCGETNEIPLNVINQVAHLKNSSVYLLGKDFYYDNEKLFLSNNTF 241 Query: 237 AFSDAHGTLENLPLPLVPQPNAATALAALRA-------SGLEVSENAIRDGIASAILPGR 289 F L++L + L A AL+A + +++ + IR ++ +PGR Sbjct: 242 DFHSDIIELKDLKISLNGAHQFLNASVALQAFLIFAQRNNIKIDKLRIRSALSKTTMPGR 301 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 F++V E P+VIFD AHN AA L +K ++ ++ AVIG++ DKD L + + Sbjct: 302 FEVVGEKPKVIFDGAHNLSAALVLRKSIKDYLEDEKIAAVIGIVDDKDKRSILTQIAPMF 361 Query: 350 DDWYCAPLEGPRGATAEQLL----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 D R ++ E N +A++ +D +T++V GS + Sbjct: 362 DRIVVTRPFSHRAQNTQETFQITREINANTILEPDPIKAYEILKSD--GYETIIVTGSLY 419 Query: 406 TVAHVMEVI 414 V ++ + I Sbjct: 420 LVGYLRDYI 428 >UniRef50_C7RCA3 FolC bifunctional protein n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RCA3_KANKD Length = 436 Score = 410 bits (1056), Expect = e-113, Method: Composition-based stats. Identities = 162/417 (38%), Positives = 235/417 (56%), Gaps = 14/417 (3%) Query: 9 AASPLASWLSYLENLHS-KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + L W+++LE H I+LGL R+ VA LG+L+ V TVAGTNGKGT TL Sbjct: 6 DFNTLNEWIAWLEQAHPIHEIELGLSRIQKVANSLGLLELNAPVITVAGTNGKGTVVATL 65 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 ES+ + V Y+SPHL+ + ERV+ G + + +F I + DI LTYFE+ Sbjct: 66 ESLAVEHDLSVASYTSPHLLAFNERVKHNGYPVSDDLLITAFRHIAQHQSDIPLTYFEFT 125 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 TL A W+FKQ +LD+++LEVGLGGR+DA NI++ D+AV+TSI LDH DWLG E + E Sbjct: 126 TLVAFWIFKQQELDLIVLEVGLGGRMDAVNIINPDIAVITSIGLDHVDWLGDTLEKVAHE 185 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS----DAHG 243 KAGI RS+KP I+ + + S + + A +++ Y +WAFS Sbjct: 186 KAGIMRSDKPVIIADSQTQSLLLPEISARQAKGVVAQLDYQYEDRGSEWAFSSVNEGQEL 245 Query: 244 TLENLPLPLVPQPNAATALAA-LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 ++ L + N A+AL A L +V+ +I+ GRFQ +S++P VI D Sbjct: 246 SINGLANNDLLVSNLASALQAFLLVFPAKVNPESIKRAYEHLQFIGRFQYLSKAPIVIVD 305 Query: 303 VAHNPHAAEYLTGRMKALPKNG--RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 VAHNP +A+ L +++ L + G + A+ GML DKDIAG+LA+ + +D W C L G Sbjct: 306 VAHNPDSAKILNQKLEQLKERGVEHITAICGMLKDKDIAGSLAY-CTAIDQWNCIDLPGQ 364 Query: 361 RGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 RG+ E+LL L + K++ + A D ++V GSF TVA ++E Sbjct: 365 RGSKGEELLNKLPEKSQKDAKTYHLLVDALDEYWQHQHQNQALVVFGSFVTVAMMLE 421 >UniRef50_D1AJ52 FolC bifunctional protein n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AJ52_SEBTE Length = 407 Score = 410 bits (1055), Expect = e-113, Method: Composition-based stats. Identities = 110/402 (27%), Positives = 190/402 (47%), Gaps = 11/402 (2%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 L+++ I LGLE + LG + + +AGTNGKG+ LE+ L+ AGYK G Sbjct: 7 LDSIDKNKIKLGLETMEKSLKILGNPERNYKIIHIAGTNGKGSAAAFLEAGLIEAGYKTG 66 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSALWLFKQ 137 Y+SP + R+ ER+ + +E+ + + ++ A DI LTYFE T K Sbjct: 67 KYTSPEIYRFNERITINREEISDGDVELYYEKVNKALELSDIKLTYFEITTAMMFLYMKD 126 Query: 138 AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKP 197 +D ++LE GLGGR DATN V ++++T+++ DH ++LG I EKAGI + + P Sbjct: 127 KNIDYLVLETGLGGRTDATNTVTPVISLITNVSFDHMEFLGNTLREIAHEKAGIIKKDIP 186 Query: 198 AIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQ 255 + PE+ I + +L++ N + D + + + L L + Sbjct: 187 VFFADDNPELLEEIKAKTENYINVLKKYEFNENSTKLDKEKLNTLVKINNKEFRLSLFGK 246 Query: 256 PNAATALAALRASG-LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLT 314 L A A L + + I+ + + GRFQI +E+P +I D AHN +A L+ Sbjct: 247 FQGKNFLLAYEALKYLGIDDEVIKRACSETVWNGRFQIAAENPFIILDGAHNKDSAAVLS 306 Query: 315 GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL----LE 370 ++ + N ++ +I +L DKD L L D + RG + +++ + Sbjct: 307 ESLREVFPNKELVYIISILRDKDNESILEELAKASDYAVFTGINNNRGQSCDEMYNKGKK 366 Query: 371 HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 + + + ++ A A++ K ++CGSF + + Sbjct: 367 YFKHSYAENTPESALKKAVSLNKK--ATVICGSFLLLKEYKK 406 >UniRef50_B3QVA8 FolC bifunctional protein n=1 Tax=Chloroherpeton thalassium ATCC 35110 RepID=B3QVA8_CHLT3 Length = 432 Score = 410 bits (1054), Expect = e-113, Method: Composition-based stats. Identities = 124/421 (29%), Positives = 196/421 (46%), Gaps = 18/421 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNGKGTTCRTLESIL 71 + +L L LGLE + + LG + + VAGTNGKG+ SI Sbjct: 3 YQETIEFLFPLRRFGQKLGLENIQALCDALGNPERNLGTIVHVAGTNGKGSVSAMTASIC 62 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 G KVG+YSSPHL +TER+++ G +P+ +I+ IS T+FE T A Sbjct: 63 KEMGKKVGLYSSPHLACFTERIKINGMSIPKEKVAEYCTQIKEIVPRISSTFFEVTTALA 122 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 F + ++DV ++E G+GGRLDATN++ + +V+T++ L+HT+WLG +E I EKA I Sbjct: 123 FKYFAEEKVDVSVIETGIGGRLDATNVIPSSYSVITNVELEHTEWLGETKEKIAVEKADI 182 Query: 192 FRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH-----GT 244 R + + I A+++ A ++ +Y + + H T Sbjct: 183 IRPKSSVFTAAKDLDALEVITRTARDRKAKIRIASALSDYQIISQEIGLLSVHLRTKRRT 242 Query: 245 LENLPLPLVPQPNAATA-LAALRASGLEVSENAIRDGIASAI----LPGRFQIVSESPRV 299 L +P A A LA L A + E IR+G+A+ R + V E P V Sbjct: 243 YHGLKVPFSGSYQAENAQLAILLAEEMGADELQIRNGLANVHQNTGHRARLERVQEKPVV 302 Query: 300 IFDVAHNPHAAEYLTGRMKALPKN-GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 + DV+HNP + + KN RV V L +KD+A +A LK+ D + + L+ Sbjct: 303 LLDVSHNPPGMQATVKTISHYRKNYARVAVVFAALQEKDVASMVAALKNGCDKIFVSELK 362 Query: 359 GPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 + A ++ + + F + A AA A + VL+ GSF+ V+ + Sbjct: 363 IEKALPATEIHQICEAQDVRAEVFPNPMDAIAAAKAFVGEDGLVLITGSFYLAGEVLAFL 422 Query: 415 D 415 + Sbjct: 423 E 423 >UniRef50_D2R4J4 FolC bifunctional protein n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R4J4_9PLAN Length = 465 Score = 409 bits (1052), Expect = e-112, Method: Composition-based stats. Identities = 132/428 (30%), Positives = 188/428 (43%), Gaps = 43/428 (10%) Query: 32 LERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTE 91 L+R+ + A LG + GT GKG+T + SILMA+GYKVG+Y+SPHL E Sbjct: 38 LQRMQSLLALLGNPHYNWPAVHITGTKGKGSTSLMMASILMASGYKVGLYTSPHLEHLEE 97 Query: 92 RVRVQGQELPESAHTASFAEIESARGDIS------------LTYFEYGTLSALWLFKQAQ 139 R V GQ++ EI SA + T+FE T A+ F + + Sbjct: 98 RFVVDGQQISSEVLVELVREIRSAVDQLDAEAEARGDLEGGPTFFEVTTAMAMLHFAREK 157 Query: 140 LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI 199 +D+ +LEVGLGGRLD+TN+ +TSI+ DH LG ++I REKAGI + P I Sbjct: 158 VDIAVLEVGLGGRLDSTNVCHPIATAITSISFDHMRQLGNTLDAIAREKAGIIKPGVPMI 217 Query: 200 VG--EPEMPSTIADVAQEKGALLQRRGVEWNY------SVTDHDWAFSDAHGT-----LE 246 G E I +A E+ A L + G E+ + + G L Sbjct: 218 CGVLANEPREAIEAIASEQRAPLVQLGKEFEAIDLGASPSGGQLMHYREPSGREGAWELN 277 Query: 247 NLPLPLVPQPNA---ATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 ++ L + A A+A L G +S IR G+ASA R + V+ P VI Sbjct: 278 DVELAMPGAHQVRNGAIAIAICHQLVQQGYRISPATIRQGLASARAQARIERVNIRPAVI 337 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP-LEG 359 DVAHN + E L + + R + ++ DK+ + L L + D L Sbjct: 338 LDVAHNVASIEALADVISQQFSSHRKILILASSRDKETSAMLGALLPLFDHVILTCYLLN 397 Query: 360 PRGATAEQLLEHLGNG-----------KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 PR QLLE ++ DS A A+ AM A ED V + GSF Sbjct: 398 PRAVEPPQLLEMARRVLSESKLPEPMLETADSPASAYARAMELAGGEDLVCITGSFFLAG 457 Query: 409 HVMEVIDA 416 + ++ Sbjct: 458 EIRPLLKR 465 >UniRef50_C2BDR7 Possible tetrahydrofolate synthase n=2 Tax=Anaerococcus RepID=C2BDR7_9FIRM Length = 424 Score = 409 bits (1052), Expect = e-112, Method: Composition-based stats. Identities = 109/423 (25%), Positives = 191/423 (45%), Gaps = 21/423 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 +L YL S D L + V + VAGTNGKG+T + L ++L Sbjct: 4 FDDYLDYLYGRGSSGEDHTLRNIRKVMEAFDNPQDKIKTIHVAGTNGKGSTAKMLANVL- 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA-----RGDISLTYFEYG 127 + K G+++SP++VR E + + G ++ I +TYFE+ Sbjct: 63 SKKVKCGIFTSPYMVRINEEISINGVDISNEDFCNLMDRIRPVAEQCDEEGYHITYFEFL 122 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGR 186 T F + ++DV ++EVGLGG LD+TNI+ +V+ SI++DH + LG E I Sbjct: 123 TAMVYLYFYEQKVDVAVIEVGLGGSLDSTNIIKSPLASVICSISMDHMNVLGSTIEEIAA 182 Query: 187 EKAGIFRSEKPAIVGEP---EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 KAGI + +P V E I + + + A L + D+ + Sbjct: 183 NKAGIIKKNRPVFVYPQTSEEAFRVIKEKSIAEQAQLFTFKKDEINIKDFSDFGNTFDFK 242 Query: 244 TLENLPLPL---VPQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 + ++L L NA+ AL L +SE+ I++GI PGR +VS +PR Sbjct: 243 SYKDLQTSLRGEHQIYNASLALMVLDYFKKDFNLSEDDIKEGIRETYNPGRVDLVSTNPR 302 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL- 357 V+ D +HN + + L +K + +++ +L DKD + + + D+ + Sbjct: 303 VLLDGSHNKESIDALLASLKKFDYD-KLIVGFSILKDKDHKDIIRKIAGLADELIITHID 361 Query: 358 EGPRGATA----EQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 + PR E+ + + ++ QA++ ++ +AK +D VL CGS + + ++ Sbjct: 362 DNPRALDTQIIDEEAKAYASDIHVIENNKQAFEFSLKEAKDKDLVLWCGSLYLIGKILSY 421 Query: 414 IDA 416 ++ Sbjct: 422 MEK 424 >UniRef50_B1CAR2 Putative uncharacterized protein n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1CAR2_9FIRM Length = 433 Score = 409 bits (1051), Expect = e-112, Method: Composition-based stats. Identities = 115/427 (26%), Positives = 192/427 (44%), Gaps = 24/427 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + Y+ + LGL+ + + RLG + V +AGTNGKG+ L +L Sbjct: 3 YKEAIEYIHMTNKFGSVLGLDNILNLLDRLGNPQKDLKVIHIAGTNGKGSISTMLNGVLT 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 AGY VG+Y+SP L ++ ER++ ++P+ E++ ++ T FE Sbjct: 63 QAGYNVGLYTSPFLEKFNERIKTNNMDIPDEDIAYYLTEVKEKINEMISEGLNHPTEFEI 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIG 185 T AL+ FK+ +D+VILEVGLGGRLDATN++ D + ++ SI+ DHT++LG + I Sbjct: 123 ITAMALYYFKEKNVDIVILEVGLGGRLDATNVIDDPILEIIASISFDHTEYLGNTLKQIA 182 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGA---LLQRRGVEWNYSVTDHDWAFSD 240 EK GI + I+ E + +++EK + +R +E + D + Sbjct: 183 YEKGGIIKENSKVILYPSHKEALDELIRISKEKNTSYIIGNKRDIELIKTDIDGSELYYK 242 Query: 241 AHGT--LENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQI 292 LE L L+ + AL L+ G ++++ I + + GRF+I Sbjct: 243 KENEFGLEKFRLSLLGENQIYNVLTVIKALETLKKDGYKINKCNIEKALTNIHFNGRFEI 302 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 ++ P +I D HN E +K K+ ++ GML DKDI L L + Sbjct: 303 FNKKPYIILDGGHNKEGIESFVKNIKLYFKDKKITLFFGMLADKDIDSALKKLIPLSKKI 362 Query: 353 YCAPLEGPRGATAEQLLEHLG---NGKSFDSVAQAWDAAMADAKAEDTVLVC-GSFHTVA 408 Y R T++ + E + N + ++ + A K D + GS + + Sbjct: 363 YTLTPNNNRAYTSKDMYEKIKKVDNHIEATYLDESDEIAGIIDKNSDEIYAFVGSLYLIG 422 Query: 409 HVMEVID 415 V + Sbjct: 423 EVRTKLK 429 >UniRef50_Q67SJ1 Folylpolyglutamate synthase n=1 Tax=Symbiobacterium thermophilum RepID=Q67SJ1_SYMTH Length = 437 Score = 409 bits (1051), Expect = e-112, Method: Composition-based stats. Identities = 141/424 (33%), Positives = 204/424 (48%), Gaps = 21/424 (4%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNGKGTTCRTLESI 70 + L+YL L + GLER + +LG V + GT+GKG+ +E+ Sbjct: 2 TYEAALAYLAGLQRFGMKPGLERTVALLEQLGRPDRRVGRVVHITGTSGKGSVAAMVEAG 61 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTAS------FAEIESARGDISLTYF 124 L AAG +VG+Y+SP L+R+ ER++V E+PE+ AE A G T F Sbjct: 62 LRAAGRRVGLYTSPPLMRFKERMQVNRAEIPEADVARLTARVAEAAEAVIAAGLEPPTEF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRES 183 E T AL F + +D ++LE G+GGR DAT V+ A V +T++ LDHT WLG E+ Sbjct: 122 EVITAMALAWFAEQSVDDLVLEAGMGGRFDATTAVEKAAVTAITNVGLDHTQWLGQTHEA 181 Query: 184 IGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGAL-LQRRGVEWNY---SVTDHDWA 237 I +KAG+ R P + G P + I VA+E+GA L ++ ++ Sbjct: 182 IAWDKAGVIRPGVPCVTGTDHPGALAVIERVAREQGAPLLHVTPADFRVLGADLSGQVAD 241 Query: 238 FSDAHGTLENLPLPLVPQPNAATALAALRASG-LEVSENAIRDGIASAILPGRFQIVS-- 294 G + L L+ + AA A ALR L V E AIR+G A PGR +++ Sbjct: 242 LRGERGWYRRVRLSLLGRHQAANAAVALRILEVLGVDEGAIREGFAHVAWPGRMELLRAA 301 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 V+ D AHNP L G + L RV V+GML DKD A LA L + + + Sbjct: 302 GGQLVLLDAAHNPAKCAALAGAVAELFPGRRVHLVVGMLADKDAAQGLAPLLPLAERVWA 361 Query: 355 APLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 E PR A +L + + +A +AA+A A D V++ GSF+TV Sbjct: 362 TTPESPRAMPAPELAQLCRELGHPALVAADLPEALEAALAAAAPGDLVVITGSFYTVGPA 421 Query: 411 MEVI 414 ++ Sbjct: 422 RRIL 425 >UniRef50_C0EVS7 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EVS7_9FIRM Length = 435 Score = 408 bits (1050), Expect = e-112, Method: Composition-based stats. Identities = 119/430 (27%), Positives = 192/430 (44%), Gaps = 34/430 (7%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 +++S +E L + GL+ + + LG + + +AGTNGKG+ L SILMAA Sbjct: 2 NYISLIEELKKRGSIPGLDAIQGLLEELGHPEDDLKIVHIAGTNGKGSVFAYLSSILMAA 61 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI------ESARGDISLTYFEYGT 128 G+KVG Y SP + Y ER ++ G + + + + E A+ + T FE T Sbjct: 62 GFKVGRYISPTISCYEERFQINGTYIAKDKLERLYGVVEEAMRKEEAKIGLRPTLFEVET 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGRE 187 + FK+ ++D ++EVG+GGRLDATN++ ++ V++SI+ DH LG E I + Sbjct: 122 ALSFLYFKEEKVDYALVEVGMGGRLDATNVIKHPELTVISSISYDHKAILGDTLEEIACQ 181 Query: 188 KAGIFRSEKPAIVGE--PEMPSTIADVAQEKGAL-LQRRGVEWN-YSVTDHDWAFSDAHG 243 KAGI + P ++ E E+ + A EK ++ + ++ + T + F Sbjct: 182 KAGIIKESAPVVLSENPEEVCKVVKHEAAEKKVHCIEVKPQDYEILAETPYGSTFLWKEQ 241 Query: 244 TLENLPLPLVPQPNAATALAALRASG--------------LEVSENAIRD----GIASAI 285 E NA TAL A E+ I+ GI I Sbjct: 242 RYETKLPGNHQISNAVTALTASEYLFEKDYEKNEARKKIPKELDTMNIKAAQQGGIIRTI 301 Query: 286 LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 PGR +++ + P D AHNP A L ++ N R++ ++G+L DK+ L +L Sbjct: 302 WPGRLEVLKKEPLFYRDGAHNPDGARKLASFLQKHFTNKRIIYIMGVLKDKEYTKILQYL 361 Query: 346 KSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSF-----DSVAQAWDAAMADAKAEDTVLV 400 + Y RG +AE L + V A A+ A+ ED ++ Sbjct: 362 MPMAKKVYVFRPNNERGLSAEILANTIKEKADVPVMIEPDVNTAVSKALEAAQPEDILVA 421 Query: 401 CGSFHTVAHV 410 CGS + + Sbjct: 422 CGSLSFMEEM 431 >UniRef50_Q7NLP7 Folylpolyglutamate synthase n=1 Tax=Gloeobacter violaceus RepID=Q7NLP7_GLOVI Length = 413 Score = 408 bits (1049), Expect = e-112, Method: Composition-based stats. Identities = 135/408 (33%), Positives = 201/408 (49%), Gaps = 22/408 (5%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL++L + LGLER+ + RLG + A VAGTNGKG+ C L IL AGY+ Sbjct: 6 YLDHLQKFGVHLGLERIQALLKRLGEPQVAFQAVHVAGTNGKGSVCAYLSHILQTAGYRT 65 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-----LTYFEYGTLSALW 133 G Y+SPHL+ + ER+ + G + + A A A+++++ + T FE T +A Sbjct: 66 GRYTSPHLLDWNERIWIDGAFISDGALQACLAKVKASAEHLPKSLGEPTQFEIVTAAAFL 125 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F Q+ ++V ++EVGLGGRLDATN+ + +V+T I LDH D LG +I EKAGI Sbjct: 126 HFAQSAVEVAVVEVGLGGRLDATNVFEQPPASVITGIGLDHCDQLGSTLAAIAAEKAGIL 185 Query: 193 RSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 RS P + PE + + A G ++ + + W G LPL Sbjct: 186 RSGCPLVCAPLAPEAMQVVTEKALALGVVITLAEPAHEVAPGEAQW-----QGFRYRLPL 240 Query: 251 -PLVPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 V N+ATALA LR GL + E AIR G+ + + PGR+Q + E R++ D AHN Sbjct: 241 AGGVQLQNSATALATCQVLRERGLPIDETAIRTGLENTVWPGRYQWLGE--RLLLDGAHN 298 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 +A YL + L + ++G+L KD L L D + P+ R E Sbjct: 299 EDSAVYLRRYLDTLHPKESIRWIVGILESKDARAVLKALLRPGDAFVAVPVPDARSHPPE 358 Query: 367 QLLEHLGNGKSFDSVAQA--WDAAMADAKAEDTVLVCGSFHTVAHVME 412 +L + S+A A + A+ + E ++ GS + V+ Sbjct: 359 RLAS-MAQTMGIHSIASASGFSEALQLSDTEQLTVIAGSLYLAGAVLR 405 >UniRef50_B3ELQ9 FolC bifunctional protein n=2 Tax=Chlorobiaceae RepID=B3ELQ9_CHLPB Length = 436 Score = 407 bits (1047), Expect = e-112, Method: Composition-based stats. Identities = 130/422 (30%), Positives = 192/422 (45%), Gaps = 17/422 (4%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNGKGTTCRTLESI 70 +++L LH + GLER+ + +G + V +AGTNGKGT + SI Sbjct: 15 TYQDAINFLFPLHRFGMKPGLERIRSLLNAVGNPQKRLGKVVHIAGTNGKGTVAYAVASI 74 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 +AG+ G+Y+SPHLV +TER+ V G +PE A ++ D T+FE T Sbjct: 75 FSSAGFTTGLYTSPHLVSFTERICVNGCRIPEPQVAAYCDVLKEEVADRKATFFEVTTAM 134 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A F + Q +V ++E G+GGRLDATN+VD D ++ SI DHT WLG E I EKA Sbjct: 135 ACMYFAEMQAEVSVIETGMGGRLDATNVVDPDYVIIPSIGKDHTAWLGDTVEKIAAEKAA 194 Query: 191 IFRSEKPAIVG--EPEMPSTIADVAQEKGALLQR-----RGVEWNYSVTDHDWAFSDAHG 243 I + +P I A GA L V + +V + ++ Sbjct: 195 IIKKGSRVYTAVKDPAALKPIIGRAAAVGATLHVLQDFPEPVVHSAAVGELVFSLKARGA 254 Query: 244 TLENLPLPLVPQPNAATA-LAALRASGLEVSENAIRDGIASAILPG---RFQIVSESPRV 299 L + +A+ LA L A + E +IR G+ S G R + +S P + Sbjct: 255 DFRKLKSGVTGDFHASNLELAVLAAHDAGIEERSIRKGLLSMRDFGYRARLERLSGKPDL 314 Query: 300 IFDVAHNPHAAEYLTGRMKAL-PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 + DVAHNP E + VL V+G++ DKD+A + LK + L Sbjct: 315 LLDVAHNPDGMEKSVNTLLRFSHAYRNVLVVLGLVRDKDVAEVVRCLKKLTKTVITVNLL 374 Query: 359 GPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 RG A +L N ++ A+A D A +D VLV GSF+ V++++ Sbjct: 375 SERGLPASELGGMCRNEGFHAIVAETAAEALDIVKRTADKDDLVLVTGSFYLAGEVLKLM 434 Query: 415 DA 416 Sbjct: 435 KR 436 >UniRef50_C6W460 FolC bifunctional protein n=7 Tax=Bacteroidetes RepID=C6W460_DYAFD Length = 433 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 123/431 (28%), Positives = 196/431 (45%), Gaps = 27/431 (6%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 + L L +N+ ++ GL + LG + +AGTNGKG+T Sbjct: 2 TYQETIEYLYDRLPVFQNIGARAFKPGLHTTRELCKLLGDPQDQFPTIHIAGTNGKGSTS 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L +IL AGY+VG+Y+SPHL + ER+RV G + E + +S +S ++F Sbjct: 62 HMLAAILQEAGYRVGLYTSPHLKDFRERIRVNGVPVSEDFIVDFIDDQKSNIERLSPSFF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E A F ++++DV ++EVG+GGRLD+TN++ +++V+T+I+ DH +LG I Sbjct: 122 EVTVAMAFSYFGRSKVDVAVIEVGMGGRLDSTNVITPELSVITNISFDHMQFLGDTLGKI 181 Query: 185 GREKAGIFRSEKPAIVGE---PEMPSTIADVAQEKGALLQ--RRGVEWNYSVTDHDWAFS 239 EKAGI ++ P +V E E+ I A+ A L R + Y Sbjct: 182 AAEKAGIIKNAVPVVVSEDQNAEISDVITAAAENAQAPLTFAARAYDVTYVGMRDGLMLV 241 Query: 240 DAHGT------LENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIAS---- 283 + ENL L L A AL + G + + A+ + + Sbjct: 242 NIQNRGSGDLEAENLALDLTGSYQLKNVAGVWAARKALLSKGWNICDEAVIRALRAVGSI 301 Query: 284 AILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA 343 L GR+Q + ++P V D AHN + +++ K + VIG + DKDI+ L+ Sbjct: 302 TGLKGRWQQLGQAPNVYCDTAHNTAGLTATLAQFESVCKGKK-RFVIGFVGDKDISTMLS 360 Query: 344 WLKSVVDDWYCAPLEGPRGATAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAEDTVL 399 +Y R A +L LE G++F +V +A AA+ D+ D + Sbjct: 361 LFPRDA-QYYFCEPSNMRALKAPELQARALECGLAGETFGNVKEALAAALRDSAPTDAIY 419 Query: 400 VCGSFHTVAHV 410 V GS VA + Sbjct: 420 VGGSTFVVADI 430 >UniRef50_A5FMS8 FolC bifunctional protein n=21 Tax=Bacteroidetes RepID=A5FMS8_FLAJ1 Length = 408 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 122/392 (31%), Positives = 193/392 (49%), Gaps = 28/392 (7%) Query: 32 LERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTE 91 L + L+A LG + VAGTNGKG+T L S+L AGYKVG+Y+SPHL + E Sbjct: 29 LTNIKLLAEHLGNPEKKLQTIHVAGTNGKGSTSHMLASVLQEAGYKVGLYTSPHLKDFRE 88 Query: 92 RVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGG 151 R+++ GQE+ E A+ + +++FE A F + D+ I+EVGLGG Sbjct: 89 RIKINGQEITEDFVCEFIAKHKDFFEANDMSFFEMSVGLAFDYFAAEKTDIAIIEVGLGG 148 Query: 152 RLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PEMPSTI 209 RLDATNI+ V+V+T+I LDHT +LG E+I EKAGI + P ++GE PE Sbjct: 149 RLDATNIITPLVSVITNIGLDHTQFLGNTLEAIAGEKAGIIKPNVPVVIGEYTPETQPVF 208 Query: 210 ADVAQEKGALLQRRG---VEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALR 266 A+ A + E S D+ F + + + + Sbjct: 209 LAKAEANKAPIYFASDLISEVFPSDLIGDYQFHNKKTVQQTIKI-------------VNE 255 Query: 267 ASGLEVSENAIRDGIASAI----LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPK 322 + ++S+ ++ G+ + + L GR+Q + E+P+++ D AHN H + +++ K Sbjct: 256 TTDFKISDENLKSGLLNTVKNTGLQGRWQQLGENPKIVCDTAHNKHGLSVVMNQLRN-EK 314 Query: 323 NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN----GKSF 378 ++ V+G+++DKD+ L ++C+P RG E L N G+ + Sbjct: 315 YEKLHIVLGVVNDKDLDSILPLFPKEAQYYFCSP-NSSRGLPTEVLQNAAKNFGLIGEKY 373 Query: 379 DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 DSV A+ A +A D + V GS VA + Sbjct: 374 DSVESAFAKAKQNASKNDFIYVGGSTFVVAEL 405 >UniRef50_Q1QY39 FolC bifunctional protein n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QY39_CHRSD Length = 437 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 170/428 (39%), Positives = 236/428 (55%), Gaps = 23/428 (5%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP--FVFTVAGTNGKGTTCRT 66 AA+ L +WL+ LE H IDLGLERV+ VA RL +L V TVAGTNGKG+T Sbjct: 3 AATSLQAWLARLERQHPVAIDLGLERVAEVARRLALLDTPLATRVITVAGTNGKGSTVAM 62 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD---ISLTY 123 LE++ G + Y+SPHL+RY ER+R+ G E ++A F +E+AR D ++LTY Sbjct: 63 LEAVAREHGLRTAAYTSPHLLRYNERLRLAGCEADDAALVEGFEAVEAARLDGDPVTLTY 122 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE GTL+ALWL + Q DV +LEVGLGGRLDA N++D DVAVVT++A DH +LG ++ Sbjct: 123 FEAGTLAALWLIARWQPDVALLEVGLGGRLDAVNVIDPDVAVVTTVAQDHAAFLGTHLDT 182 Query: 184 IGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH-----DWAF 238 IGREKAGI R+ +PA++G +P+++ + A A + + + + D +W + Sbjct: 183 IGREKAGILRAGRPAVLGSTTLPASVRERADALSAPVFALQEAFAWRMGDRGQEGSEWQW 242 Query: 239 S-----DAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIV 293 L LP P +P NAA AL L + +++ E A R ++ +L GR Q + Sbjct: 243 QGTAPGGEKVALHGLPDPGLPLDNAAVALQTLALADVKLDETATRRALSRVVLAGRLQWM 302 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 DV HNPHAA Y+ G++ P+ GR L ++GML DKD G +A L +D W Sbjct: 303 G---PWCLDVGHNPHAAAYVAGQLAQRPRRGRRLCLLGMLADKDADGVIAALAPQIDAWV 359 Query: 354 CAPLEGPRGATAEQLL-----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 L G R A QL S A+ D +LVCGSF TVA Sbjct: 360 TVSLSGDRARDAAQLATFVEGRGAKVLHQGASPEDGVRWLHANMDNGDDILVCGSFWTVA 419 Query: 409 HVMEVIDA 416 + ++ Sbjct: 420 EALAALET 427 >UniRef50_B9ZQU2 FolC bifunctional protein n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZQU2_9GAMM Length = 443 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 168/416 (40%), Positives = 232/416 (55%), Gaps = 14/416 (3%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLE 68 + LA WL++ E LH +DL LER++LVA RLG+ P P VAGTNGKGT Sbjct: 3 YATLAEWLAFQERLHPVGMDLTLERIALVADRLGLRGPGTPRTVMVAGTNGKGTVTTRTA 62 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 ++L A G KVG+++SPHL++Y ER+R+ G + +F I+ ARGD SLTYFE+ Sbjct: 63 ALLQAQGLKVGLFTSPHLLQYNERIRLNGMTASDEDLCRAFEAIDQARGDDSLTYFEFAA 122 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+A WLF++A++DV +LEVGLGGRLDA NI DADVA VT++ LDH WLG RE IGREK Sbjct: 123 LAAAWLFREARVDVQVLEVGLGGRLDAVNIWDADVAAVTAVDLDHQAWLGDSREVIGREK 182 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE-N 247 AGI R+ +P ++GE P ++ D A+ G R G +++ V + +E N Sbjct: 183 AGIMRAGRPVVLGELSPPQSVLDHARALGCRTVRLGRDFDLLVEQERLVWRWNGVQVEWN 242 Query: 248 LP----LPLVPQPNAATALAALRASGLE--VSENAIRDGIASAILPGRFQIVSESPRVIF 301 +P L N ATALA + + G+ +S + G+ PGR Q +S P + Sbjct: 243 VPLARGLSGAALANTATALAVVESLGMSAGLSAVTMEQGL-KVRPPGRLQRLSGPPEWLL 301 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 DVAHN A L ++ P G +A++ ++ DKD + L +VD W PL+ PR Sbjct: 302 DVAHNAQAVAELARWLRENPLVGPTVALVAVMADKDRSAMWRDLDGLVDIWIPVPLDLPR 361 Query: 362 GATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A L L + + + QA A A + +V GSFHTVA V E Sbjct: 362 ALPAPDLAAELEQAGQADVRPAAGIRQALQQATDSAGIQGRCVVFGSFHTVAAVFE 417 >UniRef50_D0KZW9 FolC bifunctional protein n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0KZW9_HALNC Length = 429 Score = 405 bits (1043), Expect = e-111, Method: Composition-based stats. Identities = 157/422 (37%), Positives = 233/422 (55%), Gaps = 11/422 (2%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARL---GVLKPAPFVFTVAGTNG 59 + P + LA WL +LE + IDLGL+RV+ V +L G L P V TVAGTNG Sbjct: 1 MSHAPAEQAALAEWLLWLEARNPARIDLGLDRVADVWRKLKQEGNL-VVPKVITVAGTNG 59 Query: 60 KGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI 119 KG++ LE+IL+A GY+VG Y+SPH+ R+ ER+R+ G ++ + + ++ + G Sbjct: 60 KGSSVALLEAILLAEGYRVGAYTSPHIERFNERIRLMGADIQDHELVVAMCQLAATDGSE 119 Query: 120 SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGP 179 +LTY+E+ TL+A F +A LD+ ILEVGLGGRLDA NI+DAD+A++T+I LDH +LG Sbjct: 120 ALTYYEWATLAAFLAFCRANLDIWILEVGLGGRLDAVNILDADLALITNIGLDHQAYLGD 179 Query: 180 DRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF- 238 R IG EKAG+ R + A+ + + ++ D A G L RG ++ W Sbjct: 180 TRTQIGYEKAGVLRKGQAAVYADTDPIESVIDHANAIGCPLIVRGRDFMVEADATGWRLE 239 Query: 239 SDAHGTLENLP--LPLVPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQI-V 293 + LP NAA+ +A L+ L + ++I G+ SA GRF+I V Sbjct: 240 QGDRSSYWPLPGMFGRTQVDNAASVVALLQHPKSTLNLRASSIEAGVRSAKNRGRFEIWV 299 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 E +VI DVAHN + L + AL R LAV G L DK I ++ + D+WY Sbjct: 300 HEGRQVILDVAHNLESVRVLLDNLHALATPSRRLAVFGALDDKPIEAMISLCRPEFDEWY 359 Query: 354 CAPLEGPRGATAEQLLEHLGNGKSFD-SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 L+ R A+ +L L + + S+ A++AA A + D ++ GSF+TV+ + Sbjct: 360 LGQLDSVRSASIARLSSALDRPQISETSITSAYNAAFAHSAVGDQIIAFGSFYTVSAIRH 419 Query: 413 VI 414 V+ Sbjct: 420 VL 421 >UniRef50_UPI0001BC3950 FolC bifunctional protein n=1 Tax=Butyrivibrio crossotus DSM 2876 RepID=UPI0001BC3950 Length = 428 Score = 405 bits (1043), Expect = e-111, Method: Composition-based stats. Identities = 128/423 (30%), Positives = 197/423 (46%), Gaps = 24/423 (5%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 YL+++ GL + + L + V +AGTNGKG+T ++ IL G Sbjct: 8 KYLDSVGRMGSVPGLTAIKALLLELKNPEKNLKVIHIAGTNGKGSTGAFIDKILTNTGLT 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-----DISLTYFEYGTLSAL 132 G YSSP ++ E +R+ G+ + + E+++AR +I T FE T SA Sbjct: 68 TGRYSSPAVMEPLEIIRINGKNIGCEDFSEVVTEVKAARERLAEDNIYPTRFEVETASAF 127 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESIGREKAGI 191 F + ++DV I+E G+GG LDATN+ + + +V+TSI++DHTD+LG E I KAGI Sbjct: 128 LFFSRKKVDVAIIECGMGGLLDATNVFEEVLCSVITSISMDHTDFLGDTLEKIAFNKAGI 187 Query: 192 FRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 + P + + + I A K A L + + ++ ENL Sbjct: 188 IKDHCPVVTCNRDEAVAKVIEQEAALKKAPLIQVKDAVLSEIGSQGPELIFSYEEYENLK 247 Query: 250 LPLVPQPN---AATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 L AA A+ A L+ SG +S++ IRDGI + PGRF+I+ +P VI D Sbjct: 248 CGLKGIYQTVNAAAAIEAVKVLKNSGYGISDDNIRDGIENTYWPGRFEIIHNNPLVITDG 307 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP-RG 362 AHNP A L+ ++ N + +IG+ DKDI G L + + D+ G R Sbjct: 308 AHNPDGARALSETLRYYFGNKKHTFLIGIFKDKDIYGILDEIMDLADNVIVIETPGNIRA 367 Query: 363 ATAEQLLEHLG-----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI--D 415 A E + + N + F V + D+V+ GS + + E+I D Sbjct: 368 ADCEHVASIIKERYSINAEPFKDVKDGVLRCLELCT--DSVVTFGSLSNIKRIKEIIKND 425 Query: 416 ARR 418 RR Sbjct: 426 YRR 428 >UniRef50_B1HVC8 Folylpolyglutamate synthase n=2 Tax=Bacillaceae RepID=B1HVC8_LYSSC Length = 426 Score = 404 bits (1040), Expect = e-111, Method: Composition-based stats. Identities = 111/403 (27%), Positives = 184/403 (45%), Gaps = 22/403 (5%) Query: 35 VSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVR 94 + V A L V VAG+NGKG+T L +L AGY+VG ++SPHL R ER+ Sbjct: 24 MKEVLAHLENPHNKLRVIHVAGSNGKGSTVNALREMLQHAGYQVGAFTSPHLERVNERMT 83 Query: 95 VQGQELPESAHTASFAE----IESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLG 150 + G+ + + F + IE ++FE TL F +D+ ++E GLG Sbjct: 84 INGEPITDEQFLYYFNKLAKIIEEQYNGDFPSFFEVVTLVMFQFFADQGIDIALIETGLG 143 Query: 151 GRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPST 208 GRLDATN+V +A++T+I+L+HT +LG + EKAGI + P ++G E + Sbjct: 144 GRLDATNVVSPLLAIITTISLEHTAFLGDTFAKVASEKAGIIKKGVPVVIGVSNEEALAV 203 Query: 209 IADVAQEKGALLQRRGVEWNYS-----VTDHDWAFSDAHGTLENLPLPLVPQPN------ 257 I A + A G ++ S + + ++ + ++ L + Sbjct: 204 IKQTADAQQAQCFILGQDFTVSDILQGTDVQQFTYEKSNIVMTDIALKMAGPHQINNAIL 263 Query: 258 AATALAALRASG-LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGR 316 A TA+ ALR G + +S+ +IR G+ A GRF+ + +++ D AHN L Sbjct: 264 AITAILALREEGAITLSDQSIRHGLLYAHWAGRFEQWPQ--KIVLDGAHNSEGTAALIQT 321 Query: 317 MKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL--LEHLGN 374 +K + V L DKD A ++A + V + P A+ L L N Sbjct: 322 LKNVFPKSHYRFVYAALADKDHANSIALMDDVATSITFTQINLPNAMPAKDLSILSTNAN 381 Query: 375 GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 + ++ + + ED V++ GS + +A+V + + Sbjct: 382 KSYHEDWMESVQTVLRERAEEDVVVITGSLYFIANVRQWLQEE 424 >UniRef50_C2KWA8 Possible tetrahydrofolate synthase n=1 Tax=Oribacterium sinus F0268 RepID=C2KWA8_9FIRM Length = 447 Score = 404 bits (1040), Expect = e-111, Method: Composition-based stats. Identities = 114/425 (26%), Positives = 192/425 (45%), Gaps = 25/425 (5%) Query: 15 SWLSYLENLH---SKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 +W +E L +GL+ + + G + +AG+NGKG+ ++L+ IL Sbjct: 16 TWEECMETLGVNDWYGCKMGLQPTRNLLKKCGNPENKLRFIHIAGSNGKGSVAKSLQQIL 75 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI---SLTYFEYGT 128 +GYK G+Y SPH+ ER + G+ + + ++ + FE T Sbjct: 76 SLSGYKTGMYISPHIEIMNERYTIDGEMISDEDLKRLCLKMRELSESLEEEKPNSFEMLT 135 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDA-DVAVVTSIALDHTDWLGPDRESIGRE 187 A F + +D V+LEVGLGGRLDATN++ +++V+ I L+HT LG E I RE Sbjct: 136 ALAFCYFLEKGVDYVVLEVGLGGRLDATNVIPHKELSVIAHIGLEHTAILGDTLEEIARE 195 Query: 188 KAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQ----RRGVEWNYSVTDHDWAFSDA 241 K GI + P ++ +PE+ I + +EK A L + +++ + + FS Sbjct: 196 KGGIIAKDTPVVLMHQKPEVMEEIRRICKEKNAKLHITNPKYFHSYSFHIDNGYQYFSYR 255 Query: 242 HGTLENLPL-PLVPQPNAAT---ALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 L L NA A+ L+ G+ + E+ ++ G+ + PGRF+I+ + P Sbjct: 256 ERHEYALSLLGDYQLDNAMVICDAIDCLKERGISIPEDCVKQGLMTVTWPGRFEILKKRP 315 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 +I D AHNP A L ++ L N + ++ DKD L LK+ + + Sbjct: 316 LIILDGAHNPQAVNSLVRSIEMLFPNYKKRIFFSVMADKDYMTMLELLKNNTLSFSFFQV 375 Query: 358 EGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAED---TVLVCGSFHTVAH 409 E RG E L + G + +S+ + + + K E+ +L GS + V Sbjct: 376 ESHRGQNPEILKQQWQSHFDGEIRCPESLEEGLEWNLNAVKKEEEKTLLLCLGSLYQVGQ 435 Query: 410 VMEVI 414 + Sbjct: 436 IRNFF 440 >UniRef50_C6LLD0 Tetrahydrofolate synthase n=3 Tax=Clostridiales RepID=C6LLD0_9FIRM Length = 437 Score = 404 bits (1039), Expect = e-111, Method: Composition-based stats. Identities = 127/431 (29%), Positives = 196/431 (45%), Gaps = 21/431 (4%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 A +YL LGLE + + + LG + +AGTNGKG+ + Sbjct: 2 TAMDYTEARAYLAEAAKSGSVLGLEAMRALLSELGDPQDKLKFIHIAGTNGKGSVLAYVS 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LT 122 +IL AGY+VG Y SP L Y ER++V + + A T + A G + T Sbjct: 62 TILKEAGYRVGRYISPTLFSYRERIQVNEIYITKEALTEHTFRVREAVGRMKAAGNPLPT 121 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDR 181 FE T A F Q D+V+LE G+GG DATN V V ++TSI++DH +LG Sbjct: 122 VFEIETAIAFLYFVQEDCDIVVLETGMGGDTDATNAVQTTVLEILTSISMDHMQFLGNSL 181 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS 239 I KAGI + + + EPE I ++A + A L+ V +A Sbjct: 182 AEIAAHKAGIIKPDTVVVSAAQEPEAMRVIEEIAAGQRAQLRIADAGRAEEVAYGLFAQR 241 Query: 240 DAHGTLENLPLPLVPQPNA------ATALAALRASGLEVSENAIRDGIASAILPGRFQIV 293 + G +NL + L A+ AL+ G ++E +R G+A + GRF ++ Sbjct: 242 FSCGGYKNLEIRLAGTYQIANAVVAVEAVRALQELGFRITEEQLRQGLAKTVWRGRFTVI 301 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 + P I D AHN AAE L +K R++AV G+L DK+ L +D Sbjct: 302 CDEPLFIVDGAHNRGAAEQLRESIKTYLAGRRIIAVCGVLKDKEYEAVLQITAPYIDRMI 361 Query: 354 CAP-LEGPRGATAEQLL----EHLGNGKSFDSVAQAWDAAMADAK-AEDTVLVCGSFHTV 407 + PR AE+L +++ + ++ +S+AQA D + + A D +L GS + Sbjct: 362 TIETPDNPRALPAEELARTAQKYIPHVEAAESLAQAVDRSFSAADREGDVILAFGSLSYL 421 Query: 408 AHVMEVIDARR 418 +++ + R Sbjct: 422 GEMIKETEKWR 432 >UniRef50_A6LA17 Folylpolyglutamate synthase n=8 Tax=Bacteroidales RepID=A6LA17_PARD8 Length = 439 Score = 404 bits (1038), Expect = e-111, Method: Composition-based stats. Identities = 125/432 (28%), Positives = 204/432 (47%), Gaps = 23/432 (5%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 + L + + ++ + GL + LG A VAGTNGKG+ Sbjct: 2 TYEETLHYLYTSIPVFQHSGASAYKPGLGTSIALDDYLGNPHKAYKTIHVAGTNGKGSVS 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L +IL +G+KVG+Y+SPHLV + ER+RV G+++ + S + ++F Sbjct: 62 HLLAAILRQSGFKVGLYTSPHLVDFRERIRVNGKKISQDYVVDFVERHRSFFEPLHPSFF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E + A F+ Q++ ++EVGLGGRLD+TNI+ ++++T+I+LDHT +LG E I Sbjct: 122 ELTSSMAFEYFRDQQVNYAVIEVGLGGRLDSTNIITPILSIITNISLDHTQFLGDTEEKI 181 Query: 185 GREKAGIFRSEKPAIVGEPE---MPSTIADVAQEKGALLQRRGV------EWNYSVTDHD 235 EKAGI + PA++GE E + + A+E GA E +V Sbjct: 182 AAEKAGIIKKGVPALLGEAEKQSVYDVFKNKAEEVGAPFYYAQRMDMVKDECRLTVGGKW 241 Query: 236 WAFSDAHGTLENLPLPLVPQPNAATALAALR----ASGLEVSENAIRDGIASAI----LP 287 + S +G ++ V NA T L+A+ G+++ A+ +G A L Sbjct: 242 FFPSVEYGEIQGELGGEVQVRNAVTVLSAIHILRTELGVDIIPEAVHEGFAHVTKLTGLM 301 Query: 288 GRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKN-GRVLAVIGMLHDKDIAGTLAWLK 346 GR+Q + P VI D HN E+L +K L + G++ ++GM++DKDI G L+ + Sbjct: 302 GRWQTLRSKPTVICDTGHNVGGWEHLAEHLKVLRQYCGQIYMIVGMVNDKDIDGVLSLMP 361 Query: 347 SVVDDWYCAPLEGPRGATAEQLL----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCG 402 ++ R E H +G D+V A + A+ A+ D + + G Sbjct: 362 QDAFYFF-TQASVERAMPVEDFAVKAMRHGLSGTLCDTVQDAVEKALRRARENDLIFIGG 420 Query: 403 SFHTVAHVMEVI 414 S VA + + Sbjct: 421 STFIVADALPLF 432 >UniRef50_B4VMJ0 FolC bifunctional protein n=2 Tax=Cyanobacteria RepID=B4VMJ0_9CYAN Length = 451 Score = 404 bits (1038), Expect = e-111, Method: Composition-based stats. Identities = 126/439 (28%), Positives = 199/439 (45%), Gaps = 48/439 (10%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 S L+ + LGLER+ + A LG + VAG+NGKG+ C L S+L AGY+ Sbjct: 14 SLLQPYQRFGVHLGLERIQRLLAALGNPHQRIPMIHVAGSNGKGSVCAYLSSVLSEAGYR 73 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA---RGDISLTYFEYGTLSALWL 134 VG Y+SPHL+ +TER+ + + + ++++A + S T FE T +A Sbjct: 74 VGRYTSPHLIDWTERICINQYPISTAELVNVLEQVQAAVPPDSEESPTQFEVITAAAWLY 133 Query: 135 FKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F Q Q+D+ ++EVGLGGRLDATN+ D ++TSI+ +H LG I EKAGI + Sbjct: 134 FAQKQVDIAVIEVGLGGRLDATNVCDQPLATIITSISREHWQVLGSTLSQIATEKAGILK 193 Query: 194 SEKPAIVG--EPEMPSTIADVAQEKGALLQ--------------RRGVEWNYSVTDHDWA 237 + PAI+ PE + + ++ + R G E S + Sbjct: 194 ANCPAIIAPLPPEAKAVVQSRIEQLNCPVTWVEPAQKFNRQTVVRAGFEPRLSSIATPKS 253 Query: 238 FSDA-----------HGTLENLPLPLVPQPNA---ATALAALRAS---GLEVSENAIRDG 280 + PLPL+ + A A+A ++ G ++ ++AI G Sbjct: 254 LNPPLHQNADAPLWASYAGITYPLPLLGEIQLTNSAVAIATFQSLIRQGWQIPDSAIVSG 313 Query: 281 IASAILPGRFQIVS-ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIA 339 +A GR Q ++ R++ D AHNP AA L + L N V V+G+L K+ Sbjct: 314 MAKTQWLGRLQWTEWKNYRLLVDGAHNPAAATALREYVDTL--NTPVTWVMGILSTKEHE 371 Query: 340 GTLAWLKSVVDDWYCAPLEGPRGATAEQL-------LEHLGNGKSFDSVAQAWDAAMADA 392 G L D Y P+ A E+L L + ++ ++ A Sbjct: 372 GIFRALLRGGDRVYLVPVPDHSSAEPEELSAIARSVCPTLADCHTYPNLEAGLQA-ATAT 430 Query: 393 KAEDTVLVCGSFHTVAHVM 411 A+ T+++CGS + V + + Sbjct: 431 AADSTIVLCGSLYLVGYFL 449 >UniRef50_B6JCP5 FolC bifunctional protein n=17 Tax=Alphaproteobacteria RepID=B6JCP5_OLICO Length = 442 Score = 403 bits (1037), Expect = e-111, Method: Composition-based stats. Identities = 136/428 (31%), Positives = 191/428 (44%), Gaps = 25/428 (5%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTL 67 A L L+ L LH K IDL L R+ + L + P V VAGTNGKG+T L Sbjct: 7 APRKLDDLLARLAALHPKRIDLDLSRMHRILEALDHPERRLPPVIHVAGTNGKGSTVAFL 66 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 +I AAG +V VY+SPHLVR ER R+ G+ ++ +FA E A G +T FE Sbjct: 67 RAICEAAGLRVHVYTSPHLVRLNERFRIAGELASDAQLEDAFARCERANGGAPITLFEIE 126 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGR 186 T +A LF Q DV++LEVGLGGRLDATN+V+ +V+T + LDH ++LG I Sbjct: 127 TAAAFLLFSQHIADVLLLEVGLGGRLDATNVVETPLASVITPVGLDHFEFLGDTLIKIAT 186 Query: 187 EKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 EKAGI + P IV E E + I A++ A L EW+ V + D G Sbjct: 187 EKAGIIKRNVPVIVAEQQAEAQAVIEQTARKMRAPLFCATQEWHVGVEHGRLVYHDERGL 246 Query: 245 LENLPLPLVPQPN---AATALAALRA-SGLEVSENAIRDGIASAILPGRFQIV------- 293 L+ L + A A+A LRA L + A G+ SA P R Q + Sbjct: 247 LDVTAPRLFGRHQFDNAGLAIATLRAIPSLAIEPAAFEQGVVSAQWPARMQRLPAGTLAT 306 Query: 294 --SESPRVIFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVV 349 + + D HN + L + V+ ++GM+ +KD LA + Sbjct: 307 LAPQGCELWLDGGHNADGGRVAAAALADLGERVERPVVLIVGMMGNKDARAFLANFSGLT 366 Query: 350 DDWYCAPL-EGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADA-----KAEDTVLVCGS 403 P+ + E L + V A+A + +L+ GS Sbjct: 367 RHVLAVPILDNDNAMEPEALAAVARSLDLRADVMPGVTEALARLASLAYETPPRILITGS 426 Query: 404 FHTVAHVM 411 + HV+ Sbjct: 427 LYLAGHVL 434 >UniRef50_B2GB02 Folylpolyglutamate synthase n=11 Tax=Lactobacillus RepID=B2GB02_LACF3 Length = 440 Score = 403 bits (1037), Expect = e-111, Method: Composition-based stats. Identities = 107/438 (24%), Positives = 184/438 (42%), Gaps = 32/438 (7%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + + L+++ L+R+ L RLG + + + GTNGKG+T Sbjct: 2 EEITTYDQALAFIHGRTRFKKIPTLKRMRLFLERLGNPQEGLNMIHITGTNGKGSTVAMT 61 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI-------ESARGDIS 120 IL A+G +VG ++SP + RY ER+ + GQ + + T + + + Sbjct: 62 RDILGASGLRVGTFTSPFITRYNERMAIDGQPISDEDLTRIANRVAKVATVLDQELTEGG 121 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGP 179 T FE GT + + D+VILEVG+GG+ D+TN+++A V +T++ DH +LG Sbjct: 122 PTEFEIGTAIMFCYMNEQRPDLVILEVGIGGKWDSTNVIEAPLVTAITTVGYDHMRYLGD 181 Query: 180 DRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-- 235 E I KAGI + P ++G +A VA+ A L G +++ Sbjct: 182 TYEQIASHKAGIIKEGAPLVIGHLPTSAREVVAQVAKAHHAKLYELGTDFDAPNVTPHAL 241 Query: 236 ---WAFSDAHGTLENLPLPLVPQPNAATAL-------AALRASGLEVSENAIRDGIASAI 285 ++S L L A A AL A GL V +R G+ + Sbjct: 242 YPTVSYSGLGLHRAQFKLGLAGDYQVANAAVAITVSQLALAALGLPVLAKDVRRGLEESA 301 Query: 286 LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 P R ++V++ P +I D AHN + L +K + +V + +L DK L L Sbjct: 302 WPARMEVVNDEPLMILDGAHNLPGVQALVQTIKDDFFDRQVYLEVAILADKQYELMLGEL 361 Query: 346 KSVVD-DWYCAPLEGPRGATA--------EQLLEHLGNGKSFDSVAQAWDAAMADAKAED 396 S+ + GP + ++L + + +A+ +D Sbjct: 362 ASLANVHLLVTHFAGPAASRPSADLGLAVKELATRYP-VEYVPNWQLGIARLAQEAQGDD 420 Query: 397 TVLVCGSFHTVAHVMEVI 414 +++ GS + V+ V + + Sbjct: 421 VIIITGSLYFVSEVRQFL 438 >UniRef50_B0MYL2 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MYL2_9BACT Length = 430 Score = 403 bits (1036), Expect = e-111, Method: Composition-based stats. Identities = 127/423 (30%), Positives = 197/423 (46%), Gaps = 26/423 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 +S +SY E + GLER++ LG + F VAGTNGKG+ L S+L Sbjct: 11 FSSLVSYQEK-GPEAYKPGLERITAFCKHLGNPQRNYFTIHVAGTNGKGSVSHMLASVLQ 69 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AGY+ G+Y+SPHL + ER+ V G+ +P+ + ++ L++FE T A Sbjct: 70 QAGYRTGLYTSPHLRDFRERILVDGEMIPKQKVVNFVDKHYDCMKELGLSFFEMSTALAF 129 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F Q+ ++V ++E GLGGRLDATN++ V+V+T+I LDH LG I EKAGI Sbjct: 130 DYFDQSDVEVAVIETGLGGRLDATNLIIPIVSVITNIGLDHMALLGDTLPKIAAEKAGII 189 Query: 193 RSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEW---NYSVTDHDWAFSDAH---GT 244 + P ++GE E A + + ++ N+S FS Sbjct: 190 KKSIPVVIGEKSDEYNHVFDQAATAMMSKIVYAENDFACINHSTEGDFQKFSIQRHRDNK 249 Query: 245 LENLPLPL---VPQPNAATALAAL----RASGLEVSENAIRDGIAS----AILPGRFQIV 293 + NL L L N TA+A + + + L +S A+ +G+ + L GR+Q + Sbjct: 250 VFNLELDLTGNYQVHNILTAIAVIDLLHQETPLTISLRALTEGMRTVASGTALQGRWQKL 309 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 + P I D HN H Y+ ++ A + + V+G ++DKD++ L + Sbjct: 310 GDKPLTICDTGHNAHGIRYVAEQLAA-TPHRDLYCVLGFVNDKDLSSVLPLFPKEA-RYI 367 Query: 354 CAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 R A +L E G+ D+V+ A A A ED + + GS VA Sbjct: 368 FTQPGNERALPAGKLAEKAAAYGLRGEVADTVSGALARAREMASEEDMIFIGGSNFVVAE 427 Query: 410 VME 412 V+E Sbjct: 428 VLE 430 >UniRef50_A5TUM3 Tetrahydrofolate synthase n=15 Tax=Fusobacterium RepID=A5TUM3_FUSNP Length = 415 Score = 402 bits (1034), Expect = e-110, Method: Composition-based stats. Identities = 115/418 (27%), Positives = 201/418 (48%), Gaps = 13/418 (3%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + + L L +I LGL+ + + LG + + V + GTNGKG+ T+ Sbjct: 2 EEKMNINDLLEELYAYSMFSIRLGLDNIKEICKYLGNPEKSYKVIHITGTNGKGSVSTTV 61 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD--ISLTYFE 125 E IL+ AGYKVG Y+SPH++++ ER+ + + + + ++ + I T+FE Sbjct: 62 ERILLDAGYKVGKYTSPHILKFNERIIFNDKYISDENVAKYYERVKKIIDEHNIQATFFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T FK + D VILE G+GGR DATN+ D V+V+T+++L+HT++LG I Sbjct: 122 VTTAMMFDYFKDMKADYVILEAGMGGRYDATNVCDNIVSVITNVSLEHTEYLGDTIYKIA 181 Query: 186 REKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQR-RGVEWNYSVTDHDWAFSDAH 242 +EKAGI ++ I + P++ I + + +L++ R ++ Sbjct: 182 KEKAGIIKNCPYTIFADNNPDVKKAIEEATDKYVNVLEKYRDSTYSLDFNTFTTNILING 241 Query: 243 GTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 E N A ++ G + EN I++ + I RF++ S++P VIFD Sbjct: 242 NKYEYSLFGDYQYKNFLCAYEVVKYLG--IDENIIKEAVKKVIWQCRFEVYSKNPLVIFD 299 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPR 361 AHN E L +K V ++ +L DKD L + + + + PR Sbjct: 300 GAHNLAGVEELIKIVKQHFSKDEVTILVSILKDKDRVSMFRKLNEISSNIVLTSIPDNPR 359 Query: 362 GATAEQLLEHLGNGKSF---DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 +TA++L +++ N K F + +A++ A++ K + CGSF+ + + E ++ Sbjct: 360 ASTAKELYDYVENKKDFEYEEDPIKAYNLALS--KKRKLTICCGSFYILIKLKEGLNG 415 >UniRef50_B1FP43 FolC bifunctional protein n=1 Tax=Burkholderia ambifaria IOP40-10 RepID=B1FP43_9BURK Length = 441 Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 169/438 (38%), Positives = 224/438 (51%), Gaps = 33/438 (7%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 LA WL Y L I+LGL+R+ V +G P V TV GTNGKG+T L++ L Sbjct: 5 TLAEWLQYQTTLTVHAIELGLDRIGSVWCNMGAPAPGRIVVTVTGTNGKGSTVAMLDACL 64 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 A G + G Y+SP+L RY E++R+ G + + A+F I++ R I LT FE+ TL+A Sbjct: 65 RAMGLRTGCYTSPYLHRYNEQIRIIGNCVDDEQLVAAFERIDACRAAIPLTGFEFATLAA 124 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 L +A LDV +LEVG+GGR DA NIVDADVAV+T++ LDH WLG DR SIGREK GI Sbjct: 125 FDLMARADLDVTLLEVGMGGRTDAVNIVDADVAVITTVDLDHLAWLGQDRNSIGREKGGI 184 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV-TDHDWAFSDAHGTLENLPL 250 R +PA+VGE E P + D E+GA+ RR +++ + T W + A GT LPL Sbjct: 185 ARRGRPAVVGEHEPPQGLLDELSERGAVPVRRDIQYRFDKPTAQGWRWHHADGTTLTLPL 244 Query: 251 PL----VPQPNAATALAALRASGLEVSE-------------------NAIRDGIASAILP 287 V NAA +A L A + AI G+ S +P Sbjct: 245 LPLEAPVQYDNAACVIATLHALRDALLRCRHERGEAVEAGTFAVQFSEAIAAGLQSVRIP 304 Query: 288 GRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS 347 GR Q + P V+ DV HNP AA L ++ RV AV G L DKD+ G + L Sbjct: 305 GRLQRIKGEPDVVVDVGHNPQAALALADWLRT-SAYRRVRAVYGALTDKDVEGVVRALGP 363 Query: 348 VVDDWYCAPL--EGPRGATAEQLLEHLGNG------KSFDSVAQAWDAAMADAKAEDTVL 399 +V +W+ L E PRG +L + + VA A A A A D +L Sbjct: 364 LVAEWHLIDLSQETPRGMPMGELFTRVRAAVPRALVEVQPDVASAIVALRKSADAGDCIL 423 Query: 400 VCGSFHTVAHVMEVIDAR 417 GSF + +DA Sbjct: 424 TFGSFFVAKAALSTVDAE 441 >UniRef50_D1CGA1 FolC bifunctional protein n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CGA1_THET1 Length = 451 Score = 401 bits (1032), Expect = e-110, Method: Composition-based stats. Identities = 124/444 (27%), Positives = 198/444 (44%), Gaps = 34/444 (7%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M I A + S+ Y N + LE V L+ +G + +AGT GK Sbjct: 1 MTINSYADALRYIYSFADYERNKPRSPEGMHLENVRLLLESVGNPHEKLKLVHIAGTKGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI- 119 G+T + S+L+++GYKVG Y+SPHL + ER ++ Q + E EI+ A ++ Sbjct: 61 GSTSAMISSVLISSGYKVGTYTSPHLHTHRERYQINAQPVNEDTFVNVLNEIKPAADELA 120 Query: 120 ---SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDW 176 +T +E T A LF++ +D ++EVGLGGRLD+TN++ V+V+T+I+LDHT+ Sbjct: 121 KDRKVTTYEITTALAFKLFEEEDIDWGVIEVGLGGRLDSTNVIIPKVSVITAISLDHTEV 180 Query: 177 LGPDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDH 234 LG I EKAGI + + P ++ E + A + + E + Sbjct: 181 LGDTLAKIAAEKAGIIKPQVPVVIAPQYQEAMEVLKQRALDNHSQALIVD-ELMEARNTQ 239 Query: 235 DWAFSDAHGTL-------------ENLPLPLVPQPNAATALAALRASGL-------EVSE 274 S TL ++ +PL+ + AL A+ + L ++ Sbjct: 240 TEDLSSQSFTLHTKLCLHNQPLDSQSFTIPLIGRYQTDNALTAITTAWLLSQDAAPAINL 299 Query: 275 NAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLH 334 + +G+ + PGRF++V +P +I D AHNP + L +K L N R + V G Sbjct: 300 TTLMEGLRNVKWPGRFEVVPGTPLIILDGAHNPESVGKLKNTVKELLSNKRRIYVFGAGF 359 Query: 335 DKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMA 390 D G L L+ ++ PR E L + N + +V +A D A + Sbjct: 360 GHDFHGMLEQLRE--EELIICKSIHPRAVPPETLSQIASNLGIKHQVRPTVEEALDLAKS 417 Query: 391 DAKAEDTVLVCGSFHTVAHVMEVI 414 D V+V GS VA + Sbjct: 418 L-DDVDAVIVGGSLFVVADARLAL 440 >UniRef50_A3CKF3 Dihydrofolate synthetase, putative n=32 Tax=Streptococcus RepID=A3CKF3_STRSV Length = 464 Score = 401 bits (1032), Expect = e-110, Method: Composition-based stats. Identities = 114/422 (27%), Positives = 191/422 (45%), Gaps = 24/422 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 LS+LE + + + GLER+ + G V +AGTNGKG+T L +L G Sbjct: 9 LSWLEAYRTASPNFGLERMERLLELRGDPHLQLPVIHIAGTNGKGSTIAHLRQLLEVRGL 68 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASF-------AEIESARGDISLTYFEYGTL 129 +VG ++SP+LV Y E++ + G + + A+ + G +T FE T Sbjct: 69 RVGTFTSPYLVSYNEQIAINGNAISDQDLQRLLSLYQDLLAQHATDSGLQGVTEFEIVTA 128 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 A F Q Q+DV I+EVG+GG LD+TN+ + +T++ LDH LG E+I ++KA Sbjct: 129 LAYDYFVQQQVDVAIIEVGMGGLLDSTNVCQPLLTAITTVGLDHVALLGDSLEAIAQQKA 188 Query: 190 GIFRSEKPAIVG--EPEMPSTIADVAQEKGALL----QRRGVEWNYSVTDHDWAFSDAHG 243 GI + P + G EPE + + A EK + L Q VE S ++FS+A+ Sbjct: 189 GIIKHGVPIVTGRLEPEALAVVEQKAAEKDSPLFSWSQAYQVEPQESEEGECFSFSNAYR 248 Query: 244 TLENLPLPLVPQPNAATALAALRASGL--------EVSENAIRDGIASAILPGRFQIVSE 295 ++ L+ A A AL L +++ + + +A PGR + +S+ Sbjct: 249 AKDSYQTALMGLHQADNAGLALHLCDLYCQLQSLSLLTKAEVERALLTAEWPGRLERISD 308 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD-DWYC 354 P ++ D AHNPHA L + + + + K + + L+ + Sbjct: 309 QPLILLDGAHNPHALRSLAATLDQHYPTYKKHILFACIQTKALDDMVELLQKIPKAAISL 368 Query: 355 APLEGPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMA-DAKAEDTVLVCGSFHTVAHVME 412 PR + E + G S+ +A + + ++ +L+ GS + +A V + Sbjct: 369 TAFADPRSFSKESMQSLAEQQGLSYKEWPDYVADYLAVEHEPDELLLITGSLYFLAQVRK 428 Query: 413 VI 414 I Sbjct: 429 SI 430 >UniRef50_A9BIJ6 FolC bifunctional protein n=1 Tax=Petrotoga mobilis SJ95 RepID=A9BIJ6_PETMO Length = 438 Score = 400 bits (1030), Expect = e-110, Method: Composition-based stats. Identities = 122/431 (28%), Positives = 207/431 (48%), Gaps = 31/431 (7%) Query: 13 LASWLSYLENLHS--KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 LA+ + YL + + LGLER+ ++ R+G + + GTNGKG+ + I Sbjct: 3 LANLVDYLYQRGAANFKVKLGLERIDELSKRIGSPQNTFKSIHITGTNGKGSVTTAISRI 62 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAE-------IESARGDISLTY 123 L G KVG Y SPHLV TER++V G+ + E + E ++ + + ++ Sbjct: 63 LRFNGMKVGTYISPHLVSITERIKVNGENISEKEFVEIYNEIEEEIKTMDLKGEEYAPSF 122 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T A F++ ++DV + EVGLGGRLDATNI+++DV+V+TSI+ DH LG E+ Sbjct: 123 FEITTAMAFKYFEKQKVDVGVFEVGLGGRLDATNIINSDVSVITSISKDHIKTLGDTLEA 182 Query: 184 IGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGA-LLQRRGVEW-----NYSVTDHD 235 I EKAGI + I+G + I + A+E A + G ++ Y + ++ Sbjct: 183 IAYEKAGIIKKNNFLILGNIDESPKKVILNKAKEVNAEKIYEHGKDFYSINHRYFINNNM 242 Query: 236 WAFSDAHGTLENLPLPL---VPQPNAATALAA----LRASGLEVSENAIRDGIASAILPG 288 + + +++L N T+LAA ++ G +S +R+ +A+ G Sbjct: 243 LDYHGLNYEIKDLIFGANGTFQIENVTTSLAATEAFMQKFGKTLSIEKVREAMANFYWEG 302 Query: 289 RFQIVS-ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS 347 RF+ +++FD AHN AA+ L + + +A+IG+L DKD S Sbjct: 303 RFEYTEINGKKMVFDGAHNLAAAQQLEKSVNLYFPTQKKIALIGILDDKDYEKMSQIFAS 362 Query: 348 VVDDWYCAPLEGPRGATA----EQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 V D + RG E+ +H N + ++ ++ +++ D V GS Sbjct: 363 VFDKIIVTSVPSERGRHPELIYEEFKKHTKNVEFIKDPSEGFNKLLSE--KSDIYFVTGS 420 Query: 404 FHTVAHVMEVI 414 + + + E++ Sbjct: 421 LYLLGKMKELM 431 >UniRef50_UPI0001C16345 Folylpolyglutamate synthetase n=2 Tax=Nostocaceae RepID=UPI0001C16345 Length = 471 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 123/443 (27%), Positives = 195/443 (44%), Gaps = 45/443 (10%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 S L+ L ++LGL R+ + L + VAGTNGKG+ C L SIL +GYK Sbjct: 26 SLLQPLKHFGVNLGLNRIVKLLETLNNPHRQVPIIHVAGTNGKGSVCAYLSSILTESGYK 85 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA--RGDISLTYFEYGTLSALWLF 135 G Y+SPHL+ + ER+ + + + T ++ + T FE T ++ F Sbjct: 86 TGRYTSPHLIDWNERICINEKPIASEELTRLIEIVKGVINSNEDQPTQFEIITAASWLYF 145 Query: 136 KQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIFRS 194 Q ++D+ ++EVGLGGRLDATN+ D V V+TSI DH LG I REKAGI ++ Sbjct: 146 AQEKVDIAVVEVGLGGRLDATNVCDHPLVTVITSIGRDHWQQLGSSISDIAREKAGIIKA 205 Query: 195 EKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 P ++G + + + E + + S ++ G ++ + PL Sbjct: 206 GCPVVMGKLPEDAKRAVICRSIELESPIFVVSPAREISPGWAEYQTVGPGGRIKAIKYPL 265 Query: 253 -----VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPR-----V 299 + N+A ALA+ L+ G E+S AI G+ PGR Q + + Sbjct: 266 PLKGQIQLTNSALALASLGMLQRQGWEISGQAIIRGMEKTKWPGRMQWFNWKKDNSDCQL 325 Query: 300 IFDVAHNPHAAEYLTGRMKAL-PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 + D AHNP +A+ L + ++ +N + V+GML KD L D Y P+ Sbjct: 326 LIDGAHNPESAQVLRNYVDSIGDRNKNITWVMGMLTTKDHKDIFRELLKTKDRLYLVPVP 385 Query: 359 GPRGATAEQL----LEHLGN---GKSFDSVAQAWDAAMADAKA----------------- 394 G A + L LE + ++ + A +AA + Sbjct: 386 GSDYANLDYLKTLALETCPDLDFCAIYEDIFLALNAAFNNFNNTNNNTNNNTNNNTNNNT 445 Query: 395 --EDTVLVCGSFHTVAHVMEVID 415 V++CGS + + H ++ Sbjct: 446 NINGPVILCGSLYLIGHFFSQVN 468 >UniRef50_UPI00016C3FCF FolC bifunctional protein n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C3FCF Length = 437 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 128/432 (29%), Positives = 192/432 (44%), Gaps = 29/432 (6%) Query: 11 SPLASW---LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 LA W ++Y E + +DL LER+ + RLG + + V GT GKG+TC L Sbjct: 5 EALAFWYGRINY-EVRSAGPLDLKLERMRALLRRLGDPQDRLRLVHVTGTKGKGSTCAML 63 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-------S 120 ES+L AGY+ G+++SPHL ER++V + A E+ A + S Sbjct: 64 ESVLRTAGYRAGLFTSPHLAHIEERMQVDRVPISHGELAACMEEVAPAVRAMETDPRFPS 123 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 T+FE GT F + + D+ ++EVGLGGR D+TN+ V+V+T++ DH LG Sbjct: 124 PTFFEIGTALGFLHFVRRRCDIALIEVGLGGRFDSTNVCQPLVSVITNVGPDHMAQLGTT 183 Query: 181 RESIGREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVT--DHDW 236 E+I +KAGI + P + G + + I VA E A + GV+ + + Sbjct: 184 LEAIAFQKAGIIKRRVPVVSGVTQDGPRAVIRQVAAELSAPIWEVGVKPCSPIPSFKREE 243 Query: 237 AFSDAHGTLENLPLPLVPQPNAATALAA------LRASGLEVSENAIRDGIASAILPGRF 290 + P+ L+ A A A LR +G+ + A+ G+ P R Sbjct: 244 LHVAEEVGVRAAPIGLLGAHQRANAAVATAVLDRLRTAGMHIPAAAVARGLGEVKWPARV 303 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALPKN-GRVLAVIGMLHDKDIAGTLAWLKSVV 349 ++V E P I D AHN +AE L ++ N G V + DK A L L S Sbjct: 304 EVVRERPTTILDTAHNVPSAEALVTTLREAFPNAGTKRVVFAVSSDKQFAEILRVLASYF 363 Query: 350 DDWYCAP-LEGPRGATAEQLLEHLGNGKS------FDSVAQAWDAAMADAKAEDTVLVCG 402 D +Y PRG E L L + +AW+AA++ D V V G Sbjct: 364 DHFYFTKYSNNPRGVPTEALATALAAVAPGKPFTLHATAPKAWNAAVSTVTDTDLVCVTG 423 Query: 403 SFHTVAHVMEVI 414 S + ++ Sbjct: 424 SVFLAGELRPLM 435 >UniRef50_C0EHC4 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EHC4_9CLOT Length = 439 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 120/432 (27%), Positives = 194/432 (44%), Gaps = 21/432 (4%) Query: 4 KRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTT 63 K L ++ L + GLERV + LG + VAGTNGKG+ Sbjct: 7 KGRSNDMKDYQQALDWVHGLPPFSKRPGLERVRRLLDLLGNPQERLRFIHVAGTNGKGSV 66 Query: 64 CRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-----D 118 SIL AGY+ G+Y SP ++ + ER ++ G+ + ++ T E+ Sbjct: 67 TTMCSSILREAGYRTGLYISPFVIDFRERFQIDGEMISKAEFTRLCQEVREGYETLRAQG 126 Query: 119 ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWL 177 I + ++ T +L F + D+V EVGLGG DATNI+ AV+ I+ DHT L Sbjct: 127 ILMNEYDVITALSLLYFHNHRCDIVCFEVGLGGLYDATNIIPPPEAAVIMKISYDHTAVL 186 Query: 178 GPDRESIGREKAGIFRSEKPAIV---GEPEMPSTIADVAQEKGALL---QRRGVEWNYSV 231 G +I EKAGI + + E E + I + ++G L + G+E Sbjct: 187 GDTLTAIAGEKAGIIKRGSVCVCYPDQEEEALAVIMEQCAQQGVPLILPNQSGIELKQEG 246 Query: 232 TDHDWAFSDAHGTLENLPLPLVPQ-PNAATALAALRAS-GLEVSENAIRDGIASAILPGR 289 + +F E L LP Q NA TA+ +R +VS +R G+A P R Sbjct: 247 LEGS-SFCYDGQEYE-LALPGHHQVLNAVTAIETIRQLRDFQVSGEQLRRGLAKTTFPAR 304 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 +++S+ P ++ D AHN + + L +K + + ++ AV GML DKD LA L V Sbjct: 305 MELLSQHPLLLLDGAHNANGVQALMQAVKKIEASPKI-AVAGMLADKDYGAELALLSGAV 363 Query: 350 DDWYCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 D ++ R + +L + + + +A++ A+ A A+ V++ GS Sbjct: 364 DQLILTQVQSARAESLSRLQDAAQGHGYPVSVCEDLREAYELALKMAGADGLVVIFGSLF 423 Query: 406 TVAHVMEVIDAR 417 + + +I + Sbjct: 424 LASDLRRIILGK 435 >UniRef50_C6LLF0 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Clostridiales RepID=C6LLF0_9FIRM Length = 463 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 116/440 (26%), Positives = 191/440 (43%), Gaps = 29/440 (6%) Query: 4 KRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTT 63 K+ +SY+E++ T E + RLG + V VAGTNGKG+ Sbjct: 25 KKEVTFVMTYEEAVSYIESVPKFTTKNKPENTIEMIERLGRPERKMKVIHVAGTNGKGSV 84 Query: 64 CRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARG 117 C L S+L A G K G++ SPHLV+ ER ++ + + ++ ++ A G Sbjct: 85 CAFLSSMLTAGGKKTGLFISPHLVKINERFQINNVPVTDGEFLEAYEKVFKVIREMLADG 144 Query: 118 DISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDW 176 YFE L LF++ +++ +LE GLGGRLDATNIV+ + V+TSI+LDHT+ Sbjct: 145 FAHPAYFEILFAVCLVLFERHEVEYAVLETGLGGRLDATNIVEHPLACVITSISLDHTEI 204 Query: 177 LGPDRESIGREKAGIFRSEKPAI---VGEPEMPSTIADVAQEKGALLQRRGVE----WNY 229 LG I EKAGI + P I PE I AQE+ A + + Sbjct: 205 LGDTIGQIAWEKAGIIKEGVPVIYDGCRSPEAEEVIRKRAQEQHAPAIGLHADMYEILDK 264 Query: 230 SVTDHDWAFSDAHGTLENLPLPL---VPQPNAATALAALRASGL--EVSENAIRDGIASA 284 + D+ + + + +P NA+ AL A+ E+S + +A Sbjct: 265 TDKSIDFKLNALYYEKRKITVPYPAPYQAENASLALLAMEKIDPSHEISCDVRLQAMADT 324 Query: 285 ILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAW 344 GR + V P VI D AHN + + + R++ + + +K+ + Sbjct: 325 HWQGRMETVL--PGVIVDGAHNEDGVRQFVRTLVGVQEGRRIVLLFSAVVEKNYEQMIKT 382 Query: 345 LKSV--VDDWYCAPLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDT 397 + + + +EG R AE+L + + +A++ A+A + + Sbjct: 383 ICDTGRLSEVIATQIEGKRIVPAEELAGIFRKYTDAEVTAVPDIGKAFETALAK-RGDGL 441 Query: 398 VLVCGSFHTVAHVMEVIDAR 417 + GS + V + +I+ R Sbjct: 442 LFCVGSLYLVGEIKALIEER 461 >UniRef50_Q11UV3 Tetrahydrofolylpolyglutamate synthase (Folylpolyglutamate synthetase) n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11UV3_CYTH3 Length = 429 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 123/425 (28%), Positives = 203/425 (47%), Gaps = 25/425 (5%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 QA L + E GL V ++A A VAGTNGKG++ L Sbjct: 5 QAIQFLYTQYPAFEKQGGLAYKPGLGNVLNISAAFNNPHTAFKSIHVAGTNGKGSSSSIL 64 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 ++L +AGY VG+Y+SPH+ +TER+R+ G +P+ + ++FE Sbjct: 65 AAVLQSAGYTVGLYTSPHIHDFTERIRINGVPIPKDIVVDFVQNNTAVFDRFKPSFFEIT 124 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T+ A F + Q+D+ I+E G+GGRLDATNIV +V+++T+++LDHT +LG ++I E Sbjct: 125 TILAFVWFAKQQVDIAIIETGMGGRLDATNIVQPEVSLITNVSLDHTQFLGNTIQAIASE 184 Query: 188 KAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALL----QRRGVEWNYSVTDHDWAFSDA 241 KAGI ++ P ++ + E+ S + A + L + V+ + ++H Sbjct: 185 KAGIIKAGIPVVISELQQELISVYEEQANALNSPLIKAFEAYTVDTIITASEHTEISITD 244 Query: 242 HGTLENLPLPLVPQP--------NAATALAALRASGLEVSENAIRDGIASAI----LPGR 289 H + + L L Q T + L+ G + E++I++G+A GR Sbjct: 245 HVLKKIIALRLDLQGLYQSKNVVGVLTVIDQLKKDGWAIPEDSIKEGLAHVQQLAGFKGR 304 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 +QI+S+ P I D AHN +++ K+ + VIGM+ DKDI L+ L V Sbjct: 305 WQIISQKPLTILDAAHNEAGITLSMQQLQLYHKS--IHIVIGMVKDKDIEKVLSLL-PVQ 361 Query: 350 DDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 +Y + PR A +L G++ +V A AA +A +D + + GS + Sbjct: 362 ATYYFCQADSPRAMPAAELQTAAAVNGLQGQAITNVNDAVRAARKNAAPDDVIWIGGSLY 421 Query: 406 TVAHV 410 + Sbjct: 422 VLGEF 426 >UniRef50_A4BHC7 FolC bifunctional folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Reinekea blandensis MED297 RepID=A4BHC7_9GAMM Length = 401 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 156/410 (38%), Positives = 227/410 (55%), Gaps = 15/410 (3%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 ++ L WL Y+E +H I+LGLER+ VA L + K P V TVAGTNGKGTT + + Sbjct: 4 STDLNEWLRYIEAIHPTEIELGLERLKRVATEL-LQKTPPTVMTVAGTNGKGTTSAAIAA 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 + +AG KVG+Y+SPHL R+ ER+R+ + + + +F +E ARGD+SL+YFEY TL Sbjct: 63 LCQSAGAKVGLYTSPHLFRFNERIRINNEPVADQLLVEAFQAVEQARGDVSLSYFEYTTL 122 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +A W+F+ QLD +LE+GLGGRLDA N++D D+AVVT++ LDH +LG E IGREKA Sbjct: 123 AAFWVFEHEQLDAWVLEIGLGGRLDAVNLIDPDIAVVTNVGLDHQGFLGDTLEEIGREKA 182 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 GI R+ +P ++G E+P ++ + AQ GA L G E + + + + L Sbjct: 183 GICRTGRPLVLGS-EVPESVLNTAQSVGAELYPFGQE--HGLNNDRLYWKTGETRQSALG 239 Query: 250 LPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP-RVIFDVAHNPH 308 LP + NAA AL A S + + + +PGR Q RVI DV HNPH Sbjct: 240 LP---RANAAAALQAFALSPWSLPVEECASVLQALSVPGRLQSFQHQGRRVIVDVGHNPH 296 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 AA Y+ ++ R +GML DKD G + L+ + L PRG TA+ L Sbjct: 297 AAAYIASQLL----PERFHVALGMLADKDSDGFIRALQPAMLSLSTVSLNVPRGLTAQAL 352 Query: 369 LEHLGNGK--SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 + D++ + A + + + + GSF+TV M+ ++ Sbjct: 353 GDRTTQPVLCQADTIEE-LMAVLDREHPGEPLFIGGSFYTVCAAMDFLEK 401 >UniRef50_C5BL57 FolC bifunctional protein n=1 Tax=Teredinibacter turnerae T7901 RepID=C5BL57_TERTT Length = 436 Score = 399 bits (1026), Expect = e-109, Method: Composition-based stats. Identities = 155/434 (35%), Positives = 218/434 (50%), Gaps = 29/434 (6%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLG----------VLKPAPFVFTVAGTN 58 + L WL++LE LH I+LGL R+S VA LG A + TVAGTN Sbjct: 3 QHNTLNEWLAWLETLHPTEIELGLSRISTVARTLGFAPVMQSRDDSAPVACKLITVAGTN 62 Query: 59 GKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD 118 GKG+ + E++ AG G Y+SPH++ Y ER+R+ G + ++ +F I+ ARGD Sbjct: 63 GKGSFVTSCEALFAHAGKTTGAYTSPHILAYNERIRINGAPVSDATIIHAFERIDLARGD 122 Query: 119 ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLG 178 ++LTYFE+ TL+A +F+ A +D +LEVGLGGRLDA N DVAV+TSI LDH +WLG Sbjct: 123 LTLTYFEFSTLAAALIFRDAGVDYWLLEVGLGGRLDAVNCFFPDVAVITSIDLDHQNWLG 182 Query: 179 PDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF 238 RE+I EKAGI R P + EP P + + ++ + + + Sbjct: 183 DTREAIAVEKAGIIRPGIPVVCAEPNPPKNLTQILPQETFYIDVA-FHVLQEAGRVRFFW 241 Query: 239 SDAHGTLENLPLP-LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQI--VSE 295 +DA T + +P + A AL L G V A+ I+ L GRFQ +++ Sbjct: 242 TDAETTNSTSQVECALPLSSVAAALQVLSLEGYAVPGAALDQTISGLALAGRFQRKFLAD 301 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 V+ DVAHNP A + L + A + + A++ M+ DKDIA L + VD WY Sbjct: 302 GTEVVLDVAHNPAATQLLAKNLAANYEAQKFDALVAMMADKDIAAALQPMLQWVDHWYLL 361 Query: 356 PL-EGPRGATAEQLLEHLGNGKSFDSVAQAWD--------------AAMADAKAEDTVLV 400 L + PR AT EQ L A + A A +LV Sbjct: 362 ALADIPRAATPEQFRAQLLELGVAPENIYALEHTSDFFSTSDDSGVKTSAQASTAKRLLV 421 Query: 401 CGSFHTVAHVMEVI 414 GSF+TVA+V+ I Sbjct: 422 FGSFYTVANVLNEI 435 >UniRef50_Q3B220 Folylpolyglutamate synthetase n=8 Tax=Chlorobiaceae RepID=Q3B220_PELLD Length = 443 Score = 399 bits (1025), Expect = e-109, Method: Composition-based stats. Identities = 134/445 (30%), Positives = 205/445 (46%), Gaps = 30/445 (6%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNG 59 + + R P L +L LH I GLERV ++ G + + V VAGTNG Sbjct: 4 ITVSRYP---VTYQETLDFLFPLHRFGIKPGLERVRMLLQAAGSPERSLGMVVHVAGTNG 60 Query: 60 KGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI 119 KGT + S+ AAG K +Y+SPHLV +TER+R+ G+ +PE A ++ A + Sbjct: 61 KGTAASAMASMFTAAGKKTALYTSPHLVDFTERIRIDGRRIPEDAAARYATLLKPAALEH 120 Query: 120 SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGP 179 T+FE T A F ++V +LE G+GGRLDATN+V++D AV+T I LDHT+WLG Sbjct: 121 QSTFFEVTTAIAFAWFADCGVEVSVLETGMGGRLDATNVVESDYAVLTRIGLDHTEWLGS 180 Query: 180 DRESIGREKAGIFRSEKPAIV--------GEPEMPSTIADVAQEKGALLQRRGVEWNY-- 229 +I EKA I + G+ E + D AQ GA LQ G ++++ Sbjct: 181 TISAIAGEKAAIIKPSSRVFTSINPDADPGQSEAFGPVRDAAQGCGAPLQVVGRDFSFGG 240 Query: 230 ---SVTDHDWAFSDAHGTLENLPLPLVPQPNA---ATALAALRASGLEVSENAIRDG--- 280 A + L +P+ +A ATA+A +G V A+R+G Sbjct: 241 VVAEPGLLQLDVVTASCHYKGLRVPVTGAFHAPGIATAVAVAEDAG--VGPEAVREGLDA 298 Query: 281 IASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKA-LPKNGRVLAVIGMLHDKDIA 339 +AS GR +++ P DV+HN + L + + G++ DKD Sbjct: 299 LASTGYRGRLELLGHRPDTFLDVSHNADGMRATVDALMPFLSRYRDARVLFGLVSDKDSE 358 Query: 340 GTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAE 395 + L + + L RG +E+L E +F S +A +A + Sbjct: 359 SMIRELMRLRCRFATTGLPSERGVASEELAEICRGLGAEAVAFSSPPEALQFLREEASPD 418 Query: 396 DTVLVCGSFHTVAHVMEVIDARRSG 420 +L+ GSF+ ++E A ++G Sbjct: 419 SLILITGSFYLAGALLEKGTAGKAG 443 >UniRef50_B8GQE7 FolC bifunctional protein n=1 Tax=Thioalkalivibrio sp. HL-EbGR7 RepID=B8GQE7_THISH Length = 386 Score = 398 bits (1024), Expect = e-109, Method: Composition-based stats. Identities = 164/315 (52%), Positives = 212/315 (67%), Gaps = 9/315 (2%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L WL++ E LH + IDLGLERV+ VAARL +L PA V TVAGTNGKG+T LE+I Sbjct: 4 DTLDQWLAWQETLHPRAIDLGLERVARVAARLDLLTPACPVITVAGTNGKGSTVAMLEAI 63 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 AAGY+V Y+SPHL+RY ER+R+ G +++ +FA +++ARG+ +L+YFE+GTL+ Sbjct: 64 YRAAGYRVCAYTSPHLLRYNERIRIHGSLADDASLCRAFAAVDAARGEDTLSYFEFGTLA 123 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 ALWLF++A D+++LEVGLGGRLDA NIVD DV+VVTS+ +DH WLGPDRESIG EKAG Sbjct: 124 ALWLFREAGADILVLEVGLGGRLDAVNIVDPDVSVVTSVGIDHEQWLGPDRESIGAEKAG 183 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT--DHDWAFSDAHG-TLEN 247 IFR+++PA+ G+P P++IA A GA L G +++SV W + L++ Sbjct: 184 IFRAQRPAVCGDPTPPASIAGTAARLGAKLYAAGQAFSWSVDASGDHWQWRGPGDVVLDD 243 Query: 248 LPLPLVPQP----NAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 LP P +P NAATAL A L A V AI G+AS LPGRFQ + P VI Sbjct: 244 LPPPALPGAIQFNNAATALTAVTLLAPRCPVPREAICRGLASVSLPGRFQRLRSDPAVIL 303 Query: 302 DVAHNPHAAEYLTGR 316 DVAHNP AE L Sbjct: 304 DVAHNPQGAEVLAQN 318 >UniRef50_A8YUM7 Folylpolyglutamate synthase n=28 Tax=Lactobacillus RepID=A8YUM7_LACH4 Length = 424 Score = 398 bits (1023), Expect = e-109, Method: Composition-based stats. Identities = 110/419 (26%), Positives = 193/419 (46%), Gaps = 13/419 (3%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 + YL +L L + + +LG + + GTNGKG+T L +++ Sbjct: 7 EEVIHYLYSLPHVHPKNDLSFIKKLLQQLGNPQDQVKTIHITGTNGKGSTSYYLANLVKK 66 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHT-------ASFAEIESARGDISLTYFEY 126 AG + G++ SP++ R+ ER+++ Q++ + A++ +++ SL FEY Sbjct: 67 AGQRTGLFVSPYVYRFNERIQLNNQDISDEDLVNVANTVQAAYEKLKQEDEQFSLVTFEY 126 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 A F+Q Q D ++EVG+GG D TN++ +V+++T+I LDH +GP + I + Sbjct: 127 EVAMAFVYFEQKQCDYAVIEVGIGGEHDKTNVIIPEVSIITTIGLDHEKIIGPTIQDIAQ 186 Query: 187 EKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 EK+GI + +P ++G + S + A + A L + ++ + +SDA + Sbjct: 187 EKSGIIKQNRPVVLGNVPDSVLSILVKKADKMHAPLLQLKHDFTIETQNGRLKYSDAKRS 246 Query: 245 LENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 L P V + A A+ A L +++ I D I +PGR+ I+ + P +I D A Sbjct: 247 LSFAYRPQVEGYDIAVAVKAFLLLKLNLNDQEIEDAINQTQIPGRYHILQKEPLIILDGA 306 Query: 305 HNPHAAEYLTGRMKALPKNG--RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 HN A L + A K V A++ M+ DKD+ + D L+ PR Sbjct: 307 HNIQAMSNLLEVVHAEAKKRHSHVYALVTMMKDKDLEQVFSLFNKD-DQVLLTTLDYPRV 365 Query: 363 ATAEQLLEHLGNGKSFD-SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSG 420 A + S++ Q + A D +LV GSF+ V+ ++ +G Sbjct: 366 AKENDFPIDIQRRYSYEGDYRQGFTKLKEKMDASDILLVTGSFYLVSAILNWKGKGNAG 424 >UniRef50_C7JGW9 Bifunctional protein FolC n=8 Tax=Acetobacter pasteurianus RepID=C7JGW9_ACEP3 Length = 445 Score = 398 bits (1023), Expect = e-109, Method: Composition-based stats. Identities = 146/421 (34%), Positives = 204/421 (48%), Gaps = 28/421 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESILMAAG 75 L L NL+ IDL L R+ + A+LG + P V VAGTNGKG+TC TL +I AAG Sbjct: 21 LERLNNLYPALIDLSLGRLEALLAKLGHPEEKLPPVIHVAGTNGKGSTCATLRAIGEAAG 80 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 ++V V +SPHLV TER R+ G+ + ES A+ EIE +T FE T + LF Sbjct: 81 WRVHVMTSPHLVDVTERFRIAGKLVSESELVATLEEIEQVNDGAPITVFEVLTAAGFLLF 140 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVV-TSIALDHTDWLGPDRESIGREKAGIFRS 194 + D+ I+EVGLGGR DATN++ A + TS++ DH +LG E+I EKAGIF+ Sbjct: 141 SRHPADMAIIEVGLGGRCDATNVLRKPAACIVTSVSRDHEAFLGDTLEAIAGEKAGIFKP 200 Query: 195 EKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDH------DWAFSDAHGTLE 246 PA+ G + + A + GA L RRG EW+ S + + F+D G L Sbjct: 201 GVPAVTGNQPEAVMKVLQAQADKVGAPLYRRGAEWSISPQNDAESDTAELRFADKAGEL- 259 Query: 247 NLPLPLV----PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS-------- 294 LP P + N A+ ALR SGL V E A GI P R Q + Sbjct: 260 TLPQPALVGAWQVENVGLAVEALRVSGLHVPEQAW-QGIGRVNWPARMQQLHGKLASHLP 318 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD-WY 353 E + D HNP A L + A K+ + ++GM KD G L + W Sbjct: 319 EGWELWLDGGHNPGAGNALAQEL-AHWKDQPLHVLVGMKQTKDATGFLNPVLPFASSVWA 377 Query: 354 CAPLEGPRGATAEQLLEH-LGNGKSFDSVAQAWDAAMADA-KAEDTVLVCGSFHTVAHVM 411 + E ++E G + ++ +A DA +A + VL+CGS + + Sbjct: 378 ICEPQQHLALPVEAIVEASGGKAQIGPTLVEALDALVAQNPQQHARVLICGSLYLAGVAL 437 Query: 412 E 412 + Sbjct: 438 K 438 >UniRef50_C3J886 Folylpolyglutamate synthase n=15 Tax=Bacteria RepID=C3J886_9PORP Length = 441 Score = 397 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 133/427 (31%), Positives = 194/427 (45%), Gaps = 28/427 (6%) Query: 12 PLASWLSYLENLHSK-------TIDLGLERVSLVAARLGVLK--PAPFVFTVAGTNGKGT 62 + YL + GLERV +A +G VAGTNGKG+ Sbjct: 2 TYQQTIDYLFAATPQFEQQGGSAYKPGLERVLAMAEAIGSPHLGTGIRYIHVAGTNGKGS 61 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 T TL +IL AAGY+ G+++SPHLV + ER+R+ G + E A S + Sbjct: 62 TSSTLAAILSAAGYRTGLFTSPHLVDFRERIRIDGMPIEECAVVDFVERTRPLIERFSPS 121 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 +FE TL AL F ++DV I+EVG+GGRLD+TNI+ ++++VT+I+LDHT +LG E Sbjct: 122 FFELTTLMALHHFAAKKVDVAIIEVGMGGRLDSTNIITPELSIVTNISLDHTQFLGSTLE 181 Query: 183 SIGREKAGIFRSEKPAIVGEPEMP--STIADVAQEKGALLQRR---GVEWNYSVTDHDWA 237 I EKAGIF+ PA+VGE A+ A L V + W Sbjct: 182 EIAGEKAGIFKPNVPALVGEASASLRPVFRAKAELLDAPLYFAEDSDVLQDAEPDRGGWL 241 Query: 238 FSD-AHGTLENLPLPLVPQPNAATALAA---LRASGLEVSENAIRDGIASA----ILPGR 289 +GTL + NA T LAA L ++ A+ +G A L GR Sbjct: 242 LHTRDYGTLWGELGGAAQRLNARTILAALSILARQSFQIPRVAVEEGFAHVVERSHLLGR 301 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 +Q V+ P D HN + ++K + + V GM+ DKD L L Sbjct: 302 WQKVASQPDTYCDTGHNEAGICLVVEQLKQ-EQYQALHIVFGMVADKDWHSVLRLL-PTS 359 Query: 350 DDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 +Y R ++E+L + G F S+ + AA +A +D + + GS + Sbjct: 360 AHYYFVQPTSDRALSSEELAQEARSIGLEGSVFPSIEEGCLAAQKEALPQDLIYIGGSNY 419 Query: 406 TVAHVME 412 VA ++ Sbjct: 420 VVAEALK 426 >UniRef50_A6DMK1 Folylpolyglutamate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DMK1_9BACT Length = 423 Score = 397 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 127/417 (30%), Positives = 192/417 (46%), Gaps = 25/417 (5%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 + YL++L I LGLE + + LG + VAGTNGKG+TC + + Sbjct: 6 TFSDAEKYLDSLLVFGIKLGLENMIQLNQLLGDPASSLKFVHVAGTNGKGSTCAMIATAC 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFE 125 AG K G YSSP LV + ER R+ G + ES + + +I + ++ TYFE Sbjct: 66 KYAGLKTGFYSSPFLVNFLERWRINGSPINESIYLDAMQKIIAIEDELVERTGVKPTYFE 125 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T +AL +FK+ + +VVI E G+GGRLDATNI + + ++T+IA+DH +LG E + Sbjct: 126 VLTAAALLIFKEEKCEVVIWETGMGGRLDATNIANPLLTIITNIAMDHGSYLGDTLEEVA 185 Query: 186 REKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 +EKAGI + + P I GE PE+ A+ A + ++ + D D + Sbjct: 186 KEKAGIIKDQVPLICGERKPELRKLFAESAN--NSTQYFIDSDFTSAQVDDDILYQGKQE 243 Query: 244 TLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 N L L+ + + AL L GL S G+ A PGR Q + Sbjct: 244 I--NYKLRLLGEHQVSNSSLAIKALEVLEDQGLLESAQIAARGLQYAHWPGRIQKLPN-- 299 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 + D AHNP A E L+ + N + + GM+ DK+I TL L + + P+ Sbjct: 300 DIYVDGAHNPAAMEKLS----SCFPNKKFTVICGMMEDKEIIPTLEKLVPICTKFIAVPI 355 Query: 358 EGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 + PR A+ L N S + + VL+ GS + V+ + Sbjct: 356 KIPRAIKAQDLA-ISANTVLSCSCESSSSWEETLKQISGPVLITGSLYLSGEVLSKL 411 >UniRef50_UPI0001C36E14 FolC bifunctional protein n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C36E14 Length = 422 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 115/415 (27%), Positives = 182/415 (43%), Gaps = 21/415 (5%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 YL+ +K LGLERV + +G + V VAGTNGKG+ + S+L AGYK Sbjct: 8 EYLKAASAKGSILGLERVVELLHLMGDPQEKVKVIHVAGTNGKGSFGAMMTSVLREAGYK 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTAS--FAEIESARGDISLTYFEYGTLSALWLF 135 G +SSP + T+ R+ G E+ T +A + D T FE +A LF Sbjct: 68 TGGFSSPAITDITDSYRINGTEISHEKFTELIGWAAELCEKMDEKPTEFEIMAAAAYELF 127 Query: 136 KQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKAGIFRS 194 + D+ ++E G+GG DATN+V ++V+T++ DH +LG I KAGI + Sbjct: 128 YREGCDIAVIECGMGGDTDATNVVNKPVLSVITNVQSDHCKFLGNTIAEIAAHKAGIIKE 187 Query: 195 EKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN--LPL 250 P G + E ++ A+E GA + V+ ++ ++ + Sbjct: 188 GCPVFFGGDDAEAFEVVSAKAREVGAPFRFMDYS---DVSGVRFSLDGMEFDYKDKLYKV 244 Query: 251 PLVPQPNAATAL------AALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 PL+ AL L G + IR G+A GRF+++ P VIFD A Sbjct: 245 PLLGVYQLNNALNVIFCSEILTKKGYNIDYGDIRRGLAKTEWHGRFEMLRREPYVIFDGA 304 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNP + + ++ +V +IG++ DKD L + + + PR Sbjct: 305 HNPDGIRFASESIERYFGRKKVAMLIGVMADKDYRLYSEMLGNHAAKVFTVKPDNPRALD 364 Query: 365 AEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVC-GSFHTVAHVMEVI 414 + L + +SFD +A +A AK+ + L+ GS + EV+ Sbjct: 365 SASLAKVFSEKNISAESFDVLADGVKSAYEYAKSRNIPLIALGSLYMYREFNEVL 419 >UniRef50_B1YJU6 FolC bifunctional protein n=2 Tax=Exiguobacterium RepID=B1YJU6_EXIS2 Length = 416 Score = 395 bits (1017), Expect = e-108, Method: Composition-based stats. Identities = 125/419 (29%), Positives = 200/419 (47%), Gaps = 30/419 (7%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 L +L L + I GL R+ + A L + A VAGTNGKG+T L + +A Sbjct: 5 EDVLEWLSALLAFGIKPGLSRMEALLAELMIDPDAIPTIHVAGTNGKGSTVAFLREMGVA 64 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL-----TYFEYGT 128 G +VG ++SP+++++ ER+ + G + E+ + +++A + T FE T Sbjct: 65 EGLQVGTFTSPYIIQFEERIMLNGVPISEADLVEAANVVQAAILKLEPVIGALTEFEALT 124 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGRE 187 + A + F Q + D VI EVGLGG D+TN++ A++TSI DH LG + I + Sbjct: 125 VLAFYHFYQIRPDFVIYEVGLGGLYDSTNVLKQPKAAIITSIGHDHQAILGDTLQEIALQ 184 Query: 188 KAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSV-TDHDWAFSDAHGT 244 K GI + I G + E+ + ++ A L W+ V D+ + + T Sbjct: 185 KFGIIKQGTRVIAGKLQEELTVPLMAYCGDRQASL-----SWSQEVIRDYRLSATGTWAT 239 Query: 245 LENLP------LPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 E +P + NAA A+ + G S+ AIR G+ +A PGRF+I+S PR Sbjct: 240 YEGIPETRLGLEGMHQVHNAANAVVCAKQLGW--SKTAIRRGLRNATHPGRFEIISRKPR 297 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 +I D AHNP L R+K ++ V+ + +L DKD L L+ V D Y + Sbjct: 298 IILDGAHNPEGVTALVERLKE--ESKPVVVLCSILRDKDRKAMLRQLREVTPDIYETTFD 355 Query: 359 GPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 PR T E+L +S + D A + T++V GS + ++ V ++ A+ Sbjct: 356 FPRARTLEELEMDGAKAMELNSFFKEVDTA------DKTLIVTGSLYFISTVRTLLKAQ 408 >UniRef50_P15925 Folylpolyglutamate synthase n=9 Tax=Lactobacillus RepID=FOLC_LACCA Length = 428 Score = 395 bits (1015), Expect = e-108, Method: Composition-based stats. Identities = 114/407 (28%), Positives = 199/407 (48%), Gaps = 23/407 (5%) Query: 34 RVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERV 93 R+ + LG + V GTNGKG+ + +L A+G VG+Y+SP ++R+ ER+ Sbjct: 24 RILTLLHALGNPQQQGRYIHVTGTNGKGSAANAIAHVLEASGLTVGLYTSPFIMRFNERI 83 Query: 94 RVQGQELPESAHTASFAEIESARG-------DISLTYFEYGTLSALWLFKQAQLDVVILE 146 + + +P++A + A + +A D ++T FE+ T W F+Q Q+DV ++E Sbjct: 84 MIDHEPIPDAALVNAVAFVRAALERLQQQQADFNVTEFEFITALGYWYFRQRQVDVAVIE 143 Query: 147 VGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PE 204 VG+GG D+TN++ V+V+T +ALDH LG +I + KAGI + P + G P+ Sbjct: 144 VGIGGDTDSTNVITPVVSVLTEVALDHQKLLGHTITAIAKHKAGIIKRGIPVVTGNLVPD 203 Query: 205 MPSTIADVAQEKGALLQRRGVEWNYSVT-----DHDWAFSDAHGTLENLPLPLV---PQP 256 + +A G+ R +++ + + D G + +L +PLV Q Sbjct: 204 AAAVVAAKVATTGSQWLRFDRDFSVPKAKLHGWGQRFTYEDQDGRISDLEVPLVGDYQQR 263 Query: 257 NAATALAA----LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEY 312 N A A+ + + ++ IR G+A++ P R + +S++P ++ D AHNP Sbjct: 264 NMAIAIQTAKVYAKQTEWPLTPQNIRQGLAASHWPARLEKISDTPLIVIDGAHNPDGING 323 Query: 313 LTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL 372 L +K L + + + G+L DKD A L + Y P+ G A E E L Sbjct: 324 LITALKQLF-SQPITVIAGILADKDYAAMADRLTAAFSTVYLVPVPGTPRALPEAGYEAL 382 Query: 373 GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 G+ DS +A A++ D + +++ GS + + V + + +S Sbjct: 383 HEGRLKDSWQEALAASLNDV-PDQPIVITGSLYLASAVRQTLLGGKS 428 >UniRef50_Q31PP5 FolC bifunctional protein n=2 Tax=Synechococcus elongatus RepID=Q31PP5_SYNE7 Length = 412 Score = 394 bits (1014), Expect = e-108, Method: Composition-based stats. Identities = 132/411 (32%), Positives = 205/411 (49%), Gaps = 12/411 (2%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 LA L + + +DLGL+R V RLG + + +AGTNGKG+TC +++ L Sbjct: 2 SLAELDRLLGSFAQRGVDLGLDRSLTVLERLGNPQNQIPIVHIAGTNGKGSTCAFVDTAL 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 A GY+VG Y+SPHL+ + ER+++ GQ++ + + +A I LT FE T + Sbjct: 62 RANGYRVGRYTSPHLISWCERLQLNGQQVSSDRLLEAVQTVLAAADGIDLTPFELLTAAV 121 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKAG 190 + + LD+V++E GLGGRLDATN+V V +TSI DH LGP +I EKAG Sbjct: 122 WLVLADSDLDIVVIETGLGGRLDATNVVAQPLVTAITSIGHDHQAVLGPTLGAIAAEKAG 181 Query: 191 IFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 I +S P +VG PE + I + A++ AL+ + + + T ++ Sbjct: 182 IIKSRCPVVVGPLLPEARTVIRNRAEQLQALM----IAIEPATVIESGLWQSQGLTYQSG 237 Query: 249 PLPLVPQPNAATALAALR---ASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDVA 304 + V + N+A A+A LR G + + AI G+A PGR Q + + R++ D A Sbjct: 238 LIGDVQRINSAIAIAILRQLQQQGWGLQDAAIAQGLADTDWPGRLQWLDYQGRRLLIDGA 297 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNP AA L + L N + +IGML KD LA L D P+ + Sbjct: 298 HNPEAAIALRQAVDQLLPNQSITWLIGMLRAKDAQAVLATLLRSGDRCIAIPVPDHDCWS 357 Query: 365 AEQLLEHLGNGKSFDSVAQAWDAAMADAKA-EDTVLVCGSFHTVAHVMEVI 414 +E+L + S A W +A A+ + ++ CGS + + ++ + Sbjct: 358 SEELQTWAAAQGAIASTAADWAEGLAIAQTYPEAIVFCGSLYLLGDFLQKV 408 >UniRef50_C9M7C2 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Synergistaceae RepID=C9M7C2_9BACT Length = 439 Score = 394 bits (1013), Expect = e-108, Method: Composition-based stats. Identities = 138/433 (31%), Positives = 202/433 (46%), Gaps = 26/433 (6%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 P + L ++ S GLERVS++ LG + A +AGTNGKG+T Sbjct: 2 RPSDIALYEKVEKALSDVSSDGWHPGLERVSVLLEALGTPQ-AFPAIHLAGTNGKGSTAA 60 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS----- 120 LESI AAGYK +Y+SPHL+ ER+ V G LP + ++ Sbjct: 61 FLESIYRAAGYKTALYTSPHLIHLGERLLVNGYPLPPELWAEASQKVAQTILGHPWLSQH 120 Query: 121 -LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLG 178 TYFE T +A L + A+ DV I+E G+GGRLDATNI+ D +AV+T I DH +LG Sbjct: 121 RPTYFETLTAAAYLLVRDAKPDVAIIETGMGGRLDATNILPDCRLAVITPIDWDHMAFLG 180 Query: 179 PDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGV----EWNYSVT 232 +I EK GI +PAI + PE+ K + + S+ Sbjct: 181 NTLSAIASEKFGIIVPGRPAIFSDNHPELAPEFRACCAAKNSPAYTMDECRIFDAETSLD 240 Query: 233 DHDWAFSDAHGTLENLP--LPLVPQPNAATALAA--LRASGLEVSENAIRDGIASAILPG 288 +++ + GT L NA+ AL A + V+E A R+G+ + PG Sbjct: 241 GCEFSLTTPCGTNRWFSRLLGTYQPENASLALRATEILQKDFPVTEEARREGLRTVRWPG 300 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGR-VLAVIGMLHDKDIAGTLAWLKS 347 R ++VS P VI D AHNPH + LT + AL R + V + DKD AG +++ S Sbjct: 301 RLEVVSRDPDVILDGAHNPHGMKALTDSLLALYGKDRLLTVVFTAMADKDYAGEFSYMSS 360 Query: 348 VVD-DWYCAPLE-GPRGATAEQLLEHLGNGKSFDSVAQAWD---AAMADAKA-EDTVLVC 401 + C + R +A+ L + G F V A + AA+ A+ D V++C Sbjct: 361 RLKIRLICTRVPHNTRCESAQVLAQK-ATGYPFIDVPLAVEDPVAALEKARGFSDPVILC 419 Query: 402 GSFHTVAHVMEVI 414 GS + + + + Sbjct: 420 GSLYFIGSMRSRL 432 >UniRef50_D2RA71 Bifunctional protein FolC n=3 Tax=Bifidobacteriaceae RepID=D2RA71_GARVA Length = 485 Score = 394 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 122/431 (28%), Positives = 196/431 (45%), Gaps = 46/431 (10%) Query: 29 DLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVR 88 +L L+R+ L+ LG + + V + GTNGKG+T R ESI A G + G+Y+SPHL R Sbjct: 31 NLDLDRMRLILDILGHPEQSMRVIHITGTNGKGSTARMAESICRAYGLRTGLYTSPHLER 90 Query: 89 YTERVRVQGQELPESAHTASFAEIE----------SARGDISLTYFEYGTLSALWLFKQA 138 ER+ + GQE+ ++ + +++ A G +++FE T A+W F A Sbjct: 91 VNERIMIDGQEISDNQFVDVWDQMKDIIDMVDARMEADGKPKMSFFEVLTAMAIWAFADA 150 Query: 139 QLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPA 198 +DV ++EVG+GG DATN+++AD A++ + +DH WLG E I R KAGI + Sbjct: 151 PVDVAVMEVGMGGEWDATNVMNADAAIIGPVDMDHMQWLGNTVEEIARTKAGIIKPNCTV 210 Query: 199 IVGEPE----MPSTIADVAQEKGALLQRRG---------VEWNYSVTDHDWAFSDAHGTL 245 I+G + I +VA+ A L R V +V GT Sbjct: 211 ILGPQPHEAKVLPIIKEVAERNHATLLRDSSYGDGELEVVSRTPAVGGQVVTLRTPLGTY 270 Query: 246 ENLPLPLVPQPNAATALA-------ALRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 E++P+ + A ALA L SG + + + + ++ +PGR + V SP Sbjct: 271 EDVPVDKFGKHQAHNALAALAAAEVVLPVSG-ALDGDLVAEALSQVKVPGRIEQVRTSPT 329 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP-L 357 +I D HN +AAE L ++ +++ V+ M+ DK + L L+ ++ Sbjct: 330 IIIDGGHNVNAAESLRETIEENYHFEQLIGVVAMMADKQVEEYLGVLEPILTKIIVTRNS 389 Query: 358 EGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAED--------TVLVCGS 403 R E+L + D + A A+ +D VL+CGS Sbjct: 390 WRDRVMDPEELEKIAVGVFGEDRVIRVDELPDAIQTAVDLVDEDDELGVGYGHGVLICGS 449 Query: 404 FHTVAHVMEVI 414 F T ++ Sbjct: 450 FVTAGDARTML 460 >UniRef50_Q21IZ3 FolC bifunctional protein n=1 Tax=Saccharophagus degradans 2-40 RepID=Q21IZ3_SACD2 Length = 427 Score = 393 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 162/423 (38%), Positives = 231/423 (54%), Gaps = 26/423 (6%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLK-----------PAPFVFTVAGTNGKGTTCRTLE 68 +E LHS IDLGL R+ VA L + +P V TVAGTNGKG+ R+ E Sbjct: 1 METLHSSEIDLGLSRILSVAKSLDIFHASSAKVKNANGSSPTVITVAGTNGKGSFVRSCE 60 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 ++L A+G G ++SPH++ Y ER+RV G +L + FA+I+ ARG+ SLTYFE+G Sbjct: 61 AMLGASGMHFGSFTSPHILEYNERIRVDGVDLSDGLICDVFAQIDEARGNTSLTYFEFGA 120 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+AL F ++ D +LEVGLGGRLDA NIVDAD AV+TS+ LDH WLG E IGREK Sbjct: 121 LAALLAFHKSNCDYWVLEVGLGGRLDAVNIVDADFAVITSVGLDHEAWLGNTVEVIGREK 180 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 AGI R+ + A++ ++P ++ DVAQ G G ++ Y TD + L L Sbjct: 181 AGILRANQTAVLASKDLPDSVFDVAQTLGTKCLVGGKDYTYDKTDGGLKVKLNNNKLVEL 240 Query: 249 PLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV-IFDVAHNP 307 +P P+ A A+ + + V + +R +A+ L GRF++++ V + DVAHN Sbjct: 241 AGVNLPIPSVAAAVQVMSLLDISVQASKVRAAVAAVKLAGRFEVIAAQGNVLVLDVAHNA 300 Query: 308 HAAEYLTGRMKALPKNGR---VLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGA 363 A E L + V V+GM+ DK+IA +LA L +V W + + R A Sbjct: 301 MAMELLAKNIAKYVGENEVSSVTCVLGMMADKNIAASLASLLPIVSSWCVCDIPDNKRAA 360 Query: 364 TAEQLLE-------HLGNGKSFDSVAQAWDAAMADAKAED---TVLVCGSFHTVAHVMEV 413 TAE L E +L +VA A + + +K D V+VCGSF TV + + Sbjct: 361 TAEYLREVLIGLQPNLTQVAQHQTVAAALNECLVLSKVGDKPNLVVVCGSFFTVCNAKQY 420 Query: 414 IDA 416 ++ Sbjct: 421 LNK 423 >UniRef50_A5KJF0 Putative uncharacterized protein n=4 Tax=Clostridiales RepID=A5KJF0_9FIRM Length = 445 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 113/421 (26%), Positives = 183/421 (43%), Gaps = 21/421 (4%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL+ L LGL+ + + LG + +AGTNGKG+ +IL AGY++ Sbjct: 19 YLDELSKYGSVLGLDAIRGLLRELGNPQDDLRFIHIAGTNGKGSVLAYTSTILSEAGYRI 78 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEYGTLSAL 132 G Y SP +V Y ER++V G+ + + A +++ A G T FE T A Sbjct: 79 GRYVSPTVVSYRERIQVDGEMISKHAFAEETEKVQDAIVRLKEAGKQLPTVFEAETAIAF 138 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIGREKAGI 191 +K+ + D V+LE GLGG DATN+V V V + I++DH +G I KAGI Sbjct: 139 LYYKRMKCDFVVLESGLGGMEDATNVVKNTVCAVFSPISMDHIGVIGNTLSEIAENKAGI 198 Query: 192 FRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 + + E+ + A++ G + E + + ++ EN+ Sbjct: 199 IKPGCIVVSAPQKQEVREILEQKARQFGCPIIYAEPEKAVVLEEDYRGMRFSYKDSENIS 258 Query: 250 LPL---VPQPNAATALAALRASGLEVSEN--AIRDGIASAILPGRFQIVSESPRVIFDVA 304 + L NA TA A+ GL E A+ G GRF +SE P + D A Sbjct: 259 IRLSGKYQLINAVTAWEAVHVPGLLKKEEKRAVETGFFDTEWFGRFTCISEWPVFLVDGA 318 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-PRGA 363 HN AA+ L ++A +++ ++G+ DK+ + Y L R Sbjct: 319 HNEDAAKRLRESIEAYFPGRKLIYIMGVFQDKEYEKIIRLTIPYAKCVYTVDLPNKERTL 378 Query: 364 TAEQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 +A++L E + + + QA A+ +A +D +L GS + V E ++ Sbjct: 379 SAQKLKEAVEAQSEYVPAYAVGEIKQAVKEALENADEDDVILAFGSLSYLGKVKEAVEKE 438 Query: 418 R 418 + Sbjct: 439 Q 439 >UniRef50_Q13EP9 FolC bifunctional protein n=37 Tax=Alphaproteobacteria RepID=Q13EP9_RHOPS Length = 448 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 136/442 (30%), Positives = 194/442 (43%), Gaps = 29/442 (6%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNG 59 M PQ ++ + + L LH IDL L R+ + A L + P V +AGTNG Sbjct: 1 MSAATAPQPSALVGELRARLAQLHPAQIDLTLGRIERLLAALDHPQRRLPPVIHIAGTNG 60 Query: 60 KGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRV----QGQELPESAHTASFAEIESA 115 KG+T L +IL AAG V Y+SPHLVR E VR+ G + + A+ A E Sbjct: 61 KGSTLAFLRAILEAAGLSVHAYTSPHLVRVNETVRLGRPGGGALVSDDEFAAALAHCERV 120 Query: 116 RGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHT 174 +T FE T +ALWLF Q DV +LEVGLGGRLDATN++D V+T I +DHT Sbjct: 121 NQGAPITLFEIETAAALWLFAQHPADVTLLEVGLGGRLDATNVIDQPLACVLTPIGIDHT 180 Query: 175 DWLGPDRESIGREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVT 232 ++LGP I EKAGI R P IV + I A+ A L RG +W+ V Sbjct: 181 EFLGPTLADIAAEKAGIIRRGVPVIVAGQQNDAMDVIEREAERLRAPLHARGQQWHVEVE 240 Query: 233 DHDWAFSDAHGTLENLPLPLVPQPN---AATALAALRA-SGLEVSENAIRDGIASAILPG 288 A+ D G ++ L + A A+A LRA + A + G+ SA P Sbjct: 241 HGRLAYQDDRGLMDLTAPKLFGRHQIDNAWLAIATLRAQQRFTFDQAAYQAGLLSADWPA 300 Query: 289 RFQIVSESPRV---------IFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKD 337 R Q ++ + D HN + L + + ++ + GM+ +KD Sbjct: 301 RMQRLTTGRLIDEAPPGSELWLDGGHNADGGRVAAAALGDLEERVSRPLVIIAGMMANKD 360 Query: 338 IAGTLAWLKSVVDDWYCAPLEGPR-GATAEQLLEHLG----NGKSFDSVAQAWDAAMADA 392 + L + P+ E+L + + DSV A A Sbjct: 361 ASAFLTNFTGLTRHVIAVPIPDRDGAMPPEKLADAGRALGLRVELADSVEAALSRIAGLA 420 Query: 393 KA-EDTVLVCGSFHTVAHVMEV 413 +L+ GS + HV+ + Sbjct: 421 YELPPRILITGSLYLAGHVLRL 442 >UniRef50_A5Z386 Putative uncharacterized protein n=1 Tax=Eubacterium ventriosum ATCC 27560 RepID=A5Z386_9FIRM Length = 462 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 119/447 (26%), Positives = 195/447 (43%), Gaps = 50/447 (11%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 YL+N++ LGL + + RLG + V +AGTNGKG+ +++ILM +GYK Sbjct: 10 EYLKNVNKLGSILGLNTIKELLKRLGNPQNELKVVHIAGTNGKGSIMTFVQNILMESGYK 69 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEYGTLSA 131 VG Y SP + E +R+ + + E I+ G T FE T A Sbjct: 70 VGRYCSPAVFNEREIIRINDEYISEEQSADLLTRIKEKCDSMYSEGLPHPTSFEIETAEA 129 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESIGREKAG 190 L FK+ D+ ++E G+GG DATN+ + + +V+ +I+LDHT +LG E I + K+G Sbjct: 130 LMFFKEQNCDIALIECGMGGETDATNVFEKVLCSVIATISLDHTQFLGSTIEEITKVKSG 189 Query: 191 IFRSEKPAIVGEP--EMPSTIADVAQEKGALLQR------RGVEWNYSVTDHDWAFSDAH 242 I + P ++ + E + I V ++ + L VE + T + S+ Sbjct: 190 IIKENCPVVMSKQTVEAENVIKKVCKQNNSKLIIPTEQDFENVEIDGLTTKVTYKASNNK 249 Query: 243 GTLENL-PLPLVPQPNAATALAALRASGLEVSENA------------------------- 276 + NL L NA TA+ ++E Sbjct: 250 EYILNLQALGTYQIKNAKTAVEVALVLDKALTEKTNICDESDKKNGTGMKNNINNSGNTI 309 Query: 277 ---IRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGML 333 I+ GI + PGR +++S+ P +I D AHNP A L + N R+ ++G+L Sbjct: 310 EKNIKKGIEKTVWPGRMEVISKEPLIIIDGAHNPGAVLELRKTLDLYFTNKRITFIMGVL 369 Query: 334 HDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT----AEQLLEHLGNGKSFDSVAQAWDAAM 389 DKD + + + RG AE L+++ N + DS+ QA + ++ Sbjct: 370 SDKDFSKEAEIIADRAERIITITPNNSRGLDGHKLAETLVKYNHNVQVADSLKQAAEESI 429 Query: 390 ADAKAE--DTVLVCGSFHTVAHVMEVI 414 K D +L GS + + +V+ Sbjct: 430 DTIKENRADMILAFGSLSYLGELKQVV 456 >UniRef50_A7NFK2 FolC bifunctional protein n=2 Tax=Roseiflexus RepID=A7NFK2_ROSCS Length = 454 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 126/446 (28%), Positives = 184/446 (41%), Gaps = 36/446 (8%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 QA L S++ + L R + A LG + A VAGT GKG+T Sbjct: 2 DYQQALDYLYSFIGGQQGAQRPPPMFNLVRTRALLAALGNPQHAMPSVIVAGTKGKGSTA 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI----- 119 LE+I AAG + G+++SPHL Y ER++V Q + + I + Sbjct: 62 AFLEAIARAAGLRTGLWTSPHLHTYRERIQVNRQPITRDELVQAVESIRPIVESMANGPI 121 Query: 120 -SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLG 178 + F G AL F + +D+ ILEVG+GGR D+ +V ++VVT I+ DH D LG Sbjct: 122 GAPVTFAIGFGLALRYFAERNVDLAILEVGVGGRFDSAAVVTPILSVVTPISYDHMDLLG 181 Query: 179 PDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRG------------ 224 I EKAGI + PAI PE + A E GA L Sbjct: 182 DTLAQIAWEKAGIMKPGTPAISAPQHPEALGALIRCAAEIGAPLYVVQDAAPESAVVCEP 241 Query: 225 -VEWNYSVTDHDWAFSDAHGTLENLPLPLVP-------QPNAATALAALRASGLEVSENA 276 + + + + + + +P +P A A LR +GL +++ A Sbjct: 242 FLPGPWRIPAERYLEVEPQQRFQRDIMPSLPGIFQVVNARLATGAALLLRDAGLPITDAA 301 Query: 277 IRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDK 336 I G+ASA PGR +I+ SP ++ D AHN + + L + + R + V G DK Sbjct: 302 IAAGLASARWPGRMEIIDGSPPIVLDGAHNGESIQQLVVSLNRIFPGRRCVIVFGASRDK 361 Query: 337 DIAGTLAWLKSVVDDWYCAPLEGPRGATA-EQLLEHLGNGKSFD-------SVAQAWDAA 388 D+A + L +D PR A +L + D A+A A Sbjct: 362 DLARMIPALAPAIDALVLTASRHPRALVALHELRQQFAPLVRSDTPIDIVIDPAEALARA 421 Query: 389 MADAKAEDTVLVCGSFHTVAHVMEVI 414 A D + V GS VA E + Sbjct: 422 QDLAAPNDLICVTGSLFVVAAAREAL 447 >UniRef50_D1N952 FolC bifunctional protein n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N952_9BACT Length = 432 Score = 392 bits (1009), Expect = e-107, Method: Composition-based stats. Identities = 131/423 (30%), Positives = 192/423 (45%), Gaps = 26/423 (6%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 YL++L I GLE + R G +AGTNGKG+T LE L +AG+ Sbjct: 8 EYLDSLTMFGIKPGLEATVELMNRAGNPDRDLKFIHLAGTNGKGSTGAMLECALRSAGFT 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAH-----TASFAEIESARGDISLTYFEYGTLSAL 132 G YSSPHL+ ER RV G+ +P+ + A + D TYFE+ T+ A Sbjct: 68 TGFYSSPHLIDIRERFRVNGRAVPQGDFDAYAAELAEAARRNTGRDFRFTYFEFTTVLAA 127 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +F +A +DVVI E G+GGRLD+TN+V+ V+T+IALDH +LG + I EKAGI Sbjct: 128 LIFARAGVDVVIWETGMGGRLDSTNVVNPIATVITNIALDHQAYLGDTIDKIAWEKAGII 187 Query: 193 RSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSV---TDHDWAFSDAHGTLEN 247 + P G E + D A++ GA G E + T + + Sbjct: 188 KPAVPLFYGVMPEEARQVLLDRARQLGAAPTGPGPETAGRLHYKTANGMTVQEFEYEGRR 247 Query: 248 LPLPLV---PQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 + LPL+ + N L+ S + + DG+A+ P R Q ++E R+ D Sbjct: 248 VRLPLLGAMQRRNFRVVYPVLKFMQSRYGLDLDRALDGLANVRWPARCQQLNE--RLFVD 305 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 HNP L ++ + V DKD+AG+L + V ++ PL Sbjct: 306 GGHNPDGLAALCEALQEAAPGEKFRIVFAGFRDKDVAGSLKLIAPVAAEFVFVPLHEADR 365 Query: 363 --ATAEQLLEHLGNGKSFDSVAQ-----AWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + E+L + S S A A + A+AD+K VLV GS + V+ + Sbjct: 366 PCYSGEELCKLAAECCSVPSRAAENALLAVNDALADSKC--RVLVAGSLYLAGEVLSGMA 423 Query: 416 ARR 418 RR Sbjct: 424 DRR 426 >UniRef50_A1AXP8 FolC bifunctional protein n=5 Tax=Bacteria RepID=A1AXP8_RUTMC Length = 404 Score = 392 bits (1008), Expect = e-107, Method: Composition-based stats. Identities = 141/416 (33%), Positives = 219/416 (52%), Gaps = 25/416 (6%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + L WL++ +NLH K IDLGLERV+ V +L + V TVAGTNGKG+T + I Sbjct: 5 NTLDDWLNFQKNLHFKKIDLGLERVTKVYQKLFPKGISFKVITVAGTNGKGSTAAFINGI 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 + +KV +SSPH+++Y ER + + + ++F +IE RG +LTYFE+ TL+ Sbjct: 65 YQQSNFKVAKFSSPHILKYNERFVINDAQATDEQICSAFNKIEQIRGKTTLTYFEFSTLA 124 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 AL +F+ ++++ ILEVGLGGRLD+ NIVD DV+++T+I +DH D+LG RE IG EKAG Sbjct: 125 ALIIFELEKVNIAILEVGLGGRLDSVNIVDNDVSIITNIDIDHVDYLGDTRELIGFEKAG 184 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 I R P I + P++I+ A + A L+ + S+ + Sbjct: 185 IMRKNIPCICADINPPASISQYAHQIKAQLEFVKQRYTGSIG----------------LI 228 Query: 251 PLVPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQI-VSESPRVIFDVAHNP 307 Q NAATA+ ++ L +S I GI L RFQI + + VIFDVAHN Sbjct: 229 GKHQQQNAATAILTVQKLHKTLPISTIEIETGIKCTQLDARFQIKIINNKTVIFDVAHNA 288 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQ 367 A + L+ + + +A+ L DK+I + + ++D W PL R + Sbjct: 289 AAVKVLSAELAKQKCS--TIAIFSALEDKNIGLMINKISVIIDQWLLVPLNVSRAIGMKA 346 Query: 368 LLEHL---GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSG 420 L N + D++ A + + D +++ GSFH +A ++++ + Sbjct: 347 LSNQFDLTQNIRVCDNMQDAINQGLND-NQHQRIVIFGSFHVIADALKILTPFKKN 401 >UniRef50_B5ZCR5 FolC bifunctional protein n=2 Tax=Gluconacetobacter diazotrophicus PAl 5 RepID=B5ZCR5_GLUDA Length = 432 Score = 392 bits (1007), Expect = e-107, Method: Composition-based stats. Identities = 143/413 (34%), Positives = 201/413 (48%), Gaps = 22/413 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKP-APFVFTVAGTNGKGTTCRTLESILMAAG 75 L L L+ IDL L R+ + ARLG + P V VAGTNGKG+TC TL +I AG Sbjct: 18 LERLNRLYPALIDLSLGRLQALLARLGHPERHLPPVIHVAGTNGKGSTCATLRAIGEQAG 77 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 + V V +SPHLV TER RV G + A A EIE +T FE T + LF Sbjct: 78 WPVHVMTSPHLVDVTERFRVAGHIVSTDALVAVLEEIERVNDGAPITVFEVLTAAGFLLF 137 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAV-VTSIALDHTDWLGPDRESIGREKAGIFRS 194 + + I+EVGLGGR DATN+++ A +TSI++DH +LG +I EKAGI + Sbjct: 138 ARHPARLAIIEVGLGGRFDATNVLEKPAACAITSISMDHEAFLGDSLAAIAAEKAGIMKP 197 Query: 195 EKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 P + G + + A + GA L+ RG +W+ + T ++DA G L +LPLP Sbjct: 198 GVPVVTGRQAEAAMAVLRAQAAQCGAPLRVRGEDWDIAATPGGLRYTDARGAL-DLPLPG 256 Query: 253 V----PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS--------ESPRVI 300 + NA A+AALRASGLEV ++A GIA + P R Q + + Sbjct: 257 LPGAHQIDNAGLAVAALRASGLEVPDSAWA-GIAHTVWPARMQRLGGALAGLLPPEWELW 315 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 D HNP A + L + + V V+GM KD AG L+ + G Sbjct: 316 LDGGHNPGAGQALADVLAGW-SDRPVHLVVGMKQTKDAAGFLSPMLPHAASVQAVAEAGQ 374 Query: 361 RGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAED-TVLVCGSFHTVAHVME 412 A + + +G++ + AA+ E V++CGS + +E Sbjct: 375 HLALPVEAIIAASSGRA--TPGPTLRAALGRLTGEPARVVICGSLYLAGVALE 425 >UniRef50_D0WR93 Tetrahydrofolate synthase n=2 Tax=Actinomycetales RepID=D0WR93_9ACTO Length = 571 Score = 392 bits (1007), Expect = e-107, Method: Composition-based stats. Identities = 132/443 (29%), Positives = 203/443 (45%), Gaps = 36/443 (8%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 A + S L + LERV A LG + A + GTNGK +T R +E++L Sbjct: 129 AVYRSILTRAPEHKVQPSLERVRKALAMLGNPERAFRSIHITGTNGKTSTARMIEALLRE 188 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES----------ARGDISLTY 123 G + G ++SPHL ER+ + G + A + E+ A G +++ Sbjct: 189 RGLRTGRFTSPHLTSVRERMAIDGAAISREDFLAVWEEVNPVVELVDRESTAAGGPRMSF 248 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T+ A F A +DV ++EVG+GG DATN+++ADVAV+ +A+DH WLG E Sbjct: 249 FEVFTVMAYAAFANAPVDVAVVEVGMGGLWDATNVIEADVAVILPVAMDHERWLGHTIEE 308 Query: 184 IGREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNY-----SVTDHDW 236 I REK GI + + E E + + D +E A L G + +V Sbjct: 309 IAREKVGIVKPGSFVVSAEQEDSVAQIVMDATREAKARLVAEGPSLHLVSRETAVGGQLV 368 Query: 237 AFSDAHGTLENLPLPLVPQPN-----AATALAALRASGLEVSENAIRDGIASAILPGRFQ 291 E++PL L + A A A G + + + S PGR + Sbjct: 369 TLQTPAARYEDVPLALKGEHQARNAAIALAAAEAFFGGGAFAADVVEHAFMSVSSPGRLE 428 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 IV SP V+ D AHNPH A+ ++ GR++ V+GM+ DKD+ G L L+ V+D Sbjct: 429 IVRSSPTVVVDAAHNPHGAQATADALREYFP-GRLVGVVGMMADKDVEGFLGVLEPVLDA 487 Query: 352 WYCAPLEGPRGATAEQLLEH----LGNGKSF--DSVAQAWDAAMADAKAED-------TV 398 + R A++L + G+G+ F ++A+A D A A+++D V Sbjct: 488 VVVTDIASDRAMDADELADIAGGVFGDGRVFVERNLAEAIDRAAGLAESDDGAPMASPAV 547 Query: 399 LVCGSFHTVAHVMEVIDARRSGG 421 +V GS VA ++ + G Sbjct: 548 VVLGSIQLVAAARTLMGKPGADG 570 >UniRef50_A8RZ26 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RZ26_9CLOT Length = 477 Score = 391 bits (1006), Expect = e-107, Method: Composition-based stats. Identities = 125/434 (28%), Positives = 193/434 (44%), Gaps = 28/434 (6%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L +LE +GL+ + + L + +AGTNGKG+ L SIL Sbjct: 37 DFDGALDFLEQRSGLGSVMGLDSIRNLLRELSDPQKDLEFVHIAGTNGKGSVSACLSSIL 96 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LTYFE 125 AG + G Y+SP ++ ER +V G + E +++A G + T FE Sbjct: 97 KEAGCRTGTYTSPAVISVRERYQVDGSWITEREFALLADRVKAAAGRMEEKGRGIPTVFE 156 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESI 184 T A FK+ VV+LE GLGG DATN+V+ + AV TSI++DH LG I Sbjct: 157 IETAMAFLYFKEKGCRVVVLETGLGGEQDATNVVENTLAAVFTSISMDHMGVLGNTLGQI 216 Query: 185 GREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRG------------VEWNYS 230 KAGI + + E+ S + D A EKG + + E Sbjct: 217 AACKAGIIKPGCEVVSAHQPLEVLSVLKDRAGEKGCVFTQVDMSSLSALSCPEREENRGE 276 Query: 231 VTDHDWAFSDAHGTLENLP--LPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPG 288 ++ + + G +LP L A A +AL G+ + E+A+R G+++ PG Sbjct: 277 YAENVFTYKAMEGIRISLPGTYQLENGALALEAASALSRKGIHIPESAMRKGLSNVSWPG 336 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 RFQ++ +SP VI D AHN AA L ++ R++ ++G+ DK+ + + Sbjct: 337 RFQMLKKSPMVIVDGAHNRDAALRLRECVETCLNGRRLIFIMGVFGDKEYGLMTQIMAPL 396 Query: 349 VDDWYCAPLEGP-RGATAEQLL----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 + Y L R E L ++ ++ DSV A D A+ DA + VLV GS Sbjct: 397 AERIYTVWLPDRGRSLNPEILAREAGKYCAGTQAVDSVETALDMALKDAGEQGAVLVFGS 456 Query: 404 FHTVAHVMEVIDAR 417 + +M+ + R Sbjct: 457 LSYLGQIMKETERR 470 >UniRef50_D1AAV2 FolC bifunctional protein n=1 Tax=Thermomonospora curvata DSM 43183 RepID=D1AAV2_THECD Length = 471 Score = 391 bits (1006), Expect = e-107, Method: Composition-based stats. Identities = 130/448 (29%), Positives = 192/448 (42%), Gaps = 56/448 (12%) Query: 27 TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 D L+R++ + LG + A V V GTNGK +T R +E++L G + G+ +SPHL Sbjct: 24 KFDPTLDRIADLMDLLGRPQDAYPVIHVTGTNGKSSTARMIETLLRERGLRTGLSTSPHL 83 Query: 87 VRYTERVRVQGQELPESAHTASFA------EIESARGDISLTYFEYGTLSALWLFKQAQL 140 ER+ V G+ + E A A++ E+ A+ + L+YFE T A +F A + Sbjct: 84 TTMRERIVVDGEPISEEAFVAAYRDVAPYLEMVDAKHERPLSYFETLTAMAYAVFADAPV 143 Query: 141 DVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV 200 DV ++EVG+GG DATN+ D V+VVT I+LDH LGP E I EKAGI + A++ Sbjct: 144 DVAVIEVGMGGVWDATNVADGTVSVVTPISLDHLRHLGPTIEDIAAEKAGIIKPGAIAVL 203 Query: 201 GEPEMP--STIADVAQEKGALLQRRGVEW-----NYSVTDHDWAFSDAHGTLENLPLPLV 253 + ++P + E GA R G+E+ + +V HG E + LPL Sbjct: 204 AQQQLPVAQVLLRRVVEVGATAAREGMEFGVLGRDLAVGGQQLRLQGLHGVYEEIFLPLF 263 Query: 254 PQPN---------------------------AATALAA---LRASGLEVSENAIRDGIAS 283 AAT +AA ++ +R A Sbjct: 264 GSHQAGNAACALAAVEAFASGAPSRTGGDLSAATRIAAGEDFEGDHGQLDPALVRSAFAK 323 Query: 284 AILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA 343 PGR +I P V+ D AHNP + R++ V+ DKD+AG L Sbjct: 324 VTSPGRLEIARTGPTVLIDSAHNPAGMSATVNAITEDFGFTRLIGVVAAAGDKDVAGMLE 383 Query: 344 WLKSVVDDWYCAPLEGPRGATAEQLLEH------LGNGKSFDSVAQAWDAAMADAKAED- 396 L+ V+ + R QL E D + A D A+A A+ Sbjct: 384 QLEPVLTELIVTRNTSHRSMPPRQLGELAEGIFGAERVHVIDRLDDAIDRAVALAEETGE 443 Query: 397 ----TVLVCGSFHTVAHVMEVI--DARR 418 VL+ GS T ++ + RR Sbjct: 444 YQGAGVLITGSVVTAGEARTLLRVEERR 471 >UniRef50_B6BU94 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=beta proteobacterium KB13 RepID=B6BU94_9PROT Length = 381 Score = 391 bits (1006), Expect = e-107, Method: Composition-based stats. Identities = 124/389 (31%), Positives = 199/389 (51%), Gaps = 19/389 (4%) Query: 30 LGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRY 89 + L+RV +L L P + TVAGTNGKG+ C + IL + YK+G+Y+SPH + Sbjct: 1 MSLKRVQEFKQKL-TLNPNFKIITVAGTNGKGSVCFYINQILKHSNYKIGLYTSPHFFDF 59 Query: 90 TERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGL 149 ER+ + ++ ES S I SLT+FE TL+A+ +F +D+ ILEVGL Sbjct: 60 NERIVINSEKCSESEILQSLEYILGFDDSDSLTFFEITTLAAILIFDNHNIDIAILEVGL 119 Query: 150 GGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEMPSTI 209 GGRLDA N + D++V+TSI LDHT++LG E I EK+G+ R+ KP ++G+ + Sbjct: 120 GGRLDAVNAFEPDISVITSIGLDHTEYLGDTLEKIAVEKSGVMRATKPCVIGDENCIDIL 179 Query: 210 ADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASG 269 + A E ++ +++ ++ D + L V Q N + A+ +L G Sbjct: 180 KNQASEINSIPYFFNKDFDSNIIPFDKS-----------QLTYVQQKNLSCAIFSLHQLG 228 Query: 270 LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAV 329 L + +++ + GRF +S P VI DVAHN + + L + L N + V Sbjct: 229 LTEFTSNLKEELLQQDFFGRFHRISTKPEVIIDVAHNLDSVKNLVHSLLKL-GNKKTYFV 287 Query: 330 IGMLHDKDIAGTLAWLKSVV--DDWYCAPLEGPRGATAEQLLEHLGNGK----SFDSVAQ 383 L DKDI+ + + +W + L PR + +HL S DS+ + Sbjct: 288 FSALKDKDISSIIQLFEKFTYDSEWLISELSSPRAQKLSLIEQHLQKNNYIFDSADSIKR 347 Query: 384 AWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A++ A+ A +D ++V GSF+ ++ + E Sbjct: 348 AYELALNKALNDDRIVVFGSFYVISEIFE 376 >UniRef50_A8RV28 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RV28_9CLOT Length = 454 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 117/451 (25%), Positives = 180/451 (39%), Gaps = 54/451 (11%) Query: 18 SYLENLH-SKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 YL+ + LE V LG VAGTNGKG+ C L SIL AGY Sbjct: 6 EYLDRIPMWTRKKNSLEDVRRFLDYLGNPDRDRPAIHVAGTNGKGSVCAFLTSILGEAGY 65 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYGTLS 130 G + SPHLV ER + G+ + + + +F + A + T+FE+ Sbjct: 66 STGTFISPHLVEVRERFLINGEMVDQESFEGAFETVLEASRKLADQGLCHPTFFEFLFYM 125 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKA 189 A+ LF+ +DV+ILE G+GGRLD TN+++ V+TSI++DHT +LG I EKA Sbjct: 126 AMVLFRMHDVDVMILETGMGGRLDTTNVLERPAACVITSISMDHTRYLGDTLAKIAGEKA 185 Query: 190 GIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD----AHG 243 GI ++ P + G+PE+ + + A KGA G + Y + S G Sbjct: 186 GIIKTGVPLVFDDGQPEVSTILEGFAFRKGAARYPVGRDDFYVEEIGEKGLSINARMKDG 245 Query: 244 TLENLPLPLVPQPNAATALAALRASG----------------------------LEVSEN 275 L +P A A+ A+R +S+ Sbjct: 246 RCLELEIPFEAFYQAENAMLAVRTLDVLRYPGECPRTGCRMPGHGPCICPDGKEWGISDQ 305 Query: 276 AIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKAL--PKNGRVLAVIGML 333 I G+ + PGR + V P + D AHNP E + + + + + Sbjct: 306 HIIKGLKNTFWPGRMEQVR--PGIYLDGAHNPGGIEAFIQTAGEISDRQGKKPWLLFAAV 363 Query: 334 HDKDIAGTLAWLKSVV--DDWYCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQAWD 386 DKD L + + + RG AE+L S+ A + Sbjct: 364 SDKDYERMAEQLCKEMIWEAVGVVHMNSDRGLAAEELARVFRTYTSRPVYSYGDTKSAVE 423 Query: 387 AAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 MA+ E + GS + + + V++ + Sbjct: 424 D-MAEKSREGLLFCAGSLYLIGEIKAVLEQK 453 >UniRef50_Q49Y95 Folylpolyglutamate synthase n=66 Tax=Staphylococcaceae RepID=Q49Y95_STAS1 Length = 424 Score = 390 bits (1002), Expect = e-107, Method: Composition-based stats. Identities = 104/421 (24%), Positives = 183/421 (43%), Gaps = 20/421 (4%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L ++ I G++R+ + RL + V GTNGKG+T L S L+ GY Sbjct: 7 LYWIHERTKFGIKPGVKRMEWMLERLNNPQFNINGIHVGGTNGKGSTVSYLRSALVDNGY 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL-------TYFEYGTL 129 +VG ++SP + + ER+ + G + + A ++ + + T FE T Sbjct: 67 EVGTFTSPFIETFNERISLNGNPISDDEIVALVQHVKPVSEALEIETELGTATEFEIITT 126 Query: 130 SALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 F + +D VI+E GLG + D+TN+ ++++TSI LDHTD LG I ++K Sbjct: 127 MMFLYFGEIHPVDFVIVEAGLGIKNDSTNVFKPILSILTSIGLDHTDLLGDTYVDIAKDK 186 Query: 189 AGIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 I + P I V E I D +++ A + + D ++ + LE Sbjct: 187 GAIVKPNTPVIYAVKNDEALKVIRDYVEQQEAEGIELDRDISIISEDEEFTYRYKDYELE 246 Query: 247 NLPLPLVPQPN---AATALAALRASG----LEVSENAIRDGIASAILPGRFQIVSESPRV 299 L L +V + AA A+ AL +++ N + DGI S GR + V + P + Sbjct: 247 TLLLNMVGEHQKENAALAITALIELNEDGIVDLDFNKMIDGIESVSWTGRIEQVKDQPLM 306 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 I D AHN + E L +K + + + K I + LK++ +Y + Sbjct: 307 IMDGAHNVESVEALISTIKQYYNIENIDILFSAIKGKPINAMVDQLKTIASTFYITDFDF 366 Query: 360 PRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 P+ T E++ E + + + + + + E + + GS + ++ V ++ S Sbjct: 367 PKALTKEEIFEDVRYDQKA--LVDDYVKFIETYEGEGLI-ITGSLYFISEVKSKVNFNES 423 Query: 420 G 420 Sbjct: 424 N 424 >UniRef50_A0LA36 FolC bifunctional protein n=2 Tax=cellular organisms RepID=A0LA36_MAGSM Length = 426 Score = 390 bits (1002), Expect = e-107, Method: Composition-based stats. Identities = 130/426 (30%), Positives = 197/426 (46%), Gaps = 23/426 (5%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNGKGTTCRTL 67 + S L + L+ E+ I+L L R+ + +G + V VAGTNGKG+ Sbjct: 4 SLSVLDALLAQSESRADCIIELKLARMLDLLQAMGNPQRRLGPVVHVAGTNGKGSVIAFF 63 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 +IL AG V Y+SPHLV ER++ G + ++ ++ + T+FE Sbjct: 64 GAILRQAGRSVAAYTSPHLVTIHERIQYNGVPVEDALLRYYAQQVLALPQSQQATFFERL 123 Query: 128 TLSALWLFKQAQLD----VVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 T +A + Q VV+LE GLGGRLDATN+V + +T++ LDH +LG Sbjct: 124 TATAFAVMAHWQASDPSLVVVLETGLGGRLDATNVVQPVLTAITAMGLDHQSYLGTSMAQ 183 Query: 184 IGREKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVE--WNYSVTDHDWAFS 239 I +EKAGI ++ PA++ + E + + AQ+ GA +Q G + W + W +S Sbjct: 184 IAQEKAGILKAGVPAVLAPAQDEALAVLVQQAQQVGAPVQVAGQDYRWGQNNEGAGWWYS 243 Query: 240 DAHGTL---ENLPLPLVPQPNAATALAALR---ASGLEVSENAIRDGIASAILPGRFQIV 293 D G L E L N A A+A +R A G V +A G+ + PGR + V Sbjct: 244 DGVGQLMLPEPGLLGAHQYHNGAQAVAMVRQLVAQGWSVPSSAYAAGLTAVRWPGRLERV 303 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRV-LAVIGMLHDKDIAGTLAWLKSVVDDW 352 ++P V D AHNP A+ + GRV + + ++ DKD+AG L +V Sbjct: 304 GDAPEVWLDGAHNPAGAQVCADFFRQY---GRVDVMLFALMADKDVAGMLEPWLELVKTV 360 Query: 353 YCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 G R AE L + ++ S Q W A A +LV GS + V Sbjct: 361 VVVEPVGGRSMAAEGLAQAWRAVGVTAETAPSTEQGWQLARKKAGHAGKILVSGSLYLVG 420 Query: 409 HVMEVI 414 V +++ Sbjct: 421 EVKKLL 426 >UniRef50_A8SU33 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=A8SU33_9FIRM Length = 448 Score = 389 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 115/428 (26%), Positives = 187/428 (43%), Gaps = 28/428 (6%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 ++ Y + L S LGL+ + + RLG + V +AGTNGKG+ C L+ IL A Sbjct: 8 KYIEYTDTLGSV---LGLDSIKELLRRLGDPQNKVKVVHIAGTNGKGSICAFLDGILENA 64 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE------SARGDISLTYFEYGT 128 GY VG Y SP + Y ER ++ G + E ++ +A G T FE T Sbjct: 65 GYVVGRYISPTIFTYLERFQINGTYMDEDTFAVYLERVKNVADAMAADGLNRPTSFETET 124 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIGRE 187 A F +D+++LE G+GG LDATN+ + + ++ SI++DHT +LG + I + Sbjct: 125 AIAFCYFMDKNVDILLLETGMGGLLDATNVCKSPLCTIIASISMDHTQFLGDTLQKIYSQ 184 Query: 188 KAGIFRSEKPAI---VGEPEMPSTIA--DVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 K GI + + P + V E MP I D G + + + D + Sbjct: 185 KLGIMKKDVPCVAYPVNEDLMPQWIEKCDENATTGFSVMVNPSDIGILHSGLDGSSYIYK 244 Query: 243 GTLENLPLPLV-PQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 G +L +P + N+ A+ L+ G ++ I DG+A+ GRFQ + + P Sbjct: 245 GNTYDLAVPGIYQIYNSVVAVETAYMLQKEGYDLKNVNISDGLAATRWKGRFQKLMDVPP 304 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 V D AHNP L + ++ + G+ DKD L + + + Sbjct: 305 VYVDGAHNPGGWRALRKNIDTYFPGRDLIYICGVFRDKDYRQMLEIMMPGAGSFIAVQPD 364 Query: 359 GPRGATAEQLLE----HLGNGKSFDSVAQAWDAAMADAK--AEDTVLVCGSFHTVAHVME 412 PR + +L E ++ + D V A + A+ + + V++ GS + Sbjct: 365 NPRALSNRELGELAKMYIDSVYVQDDVDDAVEQALRISSEVEDPVVIIFGSLSFIG---P 421 Query: 413 VIDARRSG 420 +ID G Sbjct: 422 IIDRAEHG 429 >UniRef50_A1WY03 FolC bifunctional protein n=1 Tax=Halorhodospira halophila SL1 RepID=A1WY03_HALHL Length = 434 Score = 389 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 173/423 (40%), Positives = 229/423 (54%), Gaps = 17/423 (4%) Query: 5 RTPQAASP--LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 R PQ A+P L WL+ LE H IDLGLERV+ V RLGVL PA V TV GTNGKG+ Sbjct: 5 RRPQPAAPPDLEGWLARLEAAHPTAIDLGLERVAAVGLRLGVLAPAARVVTVGGTNGKGS 64 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD--IS 120 RTLE++L G +Y+SPH R+ ER+R+ G E+ ++ + +E ARGD +S Sbjct: 65 VARTLEALLRGLGVSTALYTSPHFQRFNERMRLDGVEVADAPLVKALGRVEEARGDADVS 124 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 LTYFE+ TL+A LF ++ V ILEVGLGGRLDA N +DADVAVVT IA DH ++LG D Sbjct: 125 LTYFEHTTLAAFDLFARSGARVWILEVGLGGRLDAVNAIDADVAVVTRIARDHAEFLGDD 184 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT-DHDWAFS 239 ++I EKAGIFR +PA++G+ + P+ + A E GA + + GVEW +S D W + Sbjct: 185 LQAIAAEKAGIFRKGRPAVIGQQDAPAALRQSALEVGAEVAQAGVEWTFSAEADGRWWWR 244 Query: 240 DAHGTLENLPLPLVPQPNA----ATALAALRAS--GLEVSENAIRDGIASAILPGRFQIV 293 LP +P A ATALAAL + V A+ + +PGR + + Sbjct: 245 CGEYHWGGLPASGIPGCAARGNVATALAALVQLPEAVGVDAAAVARLLDGVRVPGRLERI 304 Query: 294 SESPR-VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 + DVAHN AE L + G+ A+ + KD +A L +D W Sbjct: 305 EAGSLEWLLDVAHNADGAEELARVLDDRTVTGQTRALFAVAARKDARALVAALSGRIDAW 364 Query: 353 YCAPLEGPRGATAEQLLEHLGNG-----KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 Y L+ P A++L L + D VA A A D V+V GSF TV Sbjct: 365 YLPQLDEPDMRNADELASQLADAGESVVHCGDGVATTLAALQGQAGPGDRVVVFGSFRTV 424 Query: 408 AHV 410 A V Sbjct: 425 AAV 427 >UniRef50_B1VGM7 Dihydrofolate synthase / folylpolyglutamate synthase n=28 Tax=Actinomycetales RepID=B1VGM7_CORU7 Length = 545 Score = 389 bits (1000), Expect = e-106, Method: Composition-based stats. Identities = 136/462 (29%), Positives = 210/462 (45%), Gaps = 50/462 (10%) Query: 6 TPQAASPLASWLSYLENLHSKT-IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 T + + LA+ + L +T ID LER+ ++ LG + + VAGTNGK + Sbjct: 82 TEEDLADLAAVEAELNQRWPETKIDPSLERIEMLMDLLGNPERSFATIQVAGTNGKTSVV 141 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES---------- 114 R +ES+L A + G +SPHL TER+ V G+ + + + EI+ Sbjct: 142 RMIESLLRAFHRRTGRTTSPHLQLVTERIAVDGEPIHPQDYIRMWREIQPMVEMVDAKST 201 Query: 115 ARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHT 174 A G ++ FE A F A +DV ++E G+GG DATN+V++DV+V+T I +DHT Sbjct: 202 AEGGPQMSKFEVLVALAYSAFADAPVDVAVIETGMGGTWDATNVVNSDVSVITPIGMDHT 261 Query: 175 DWLGPDRESIGREKAGIFR-----------SEKPAIVG--EPEMPSTIADVAQEKGALLQ 221 D+LG I EKAGI + E AI+ EPE + + A E A + Sbjct: 262 DFLGDTLTEIAGEKAGIIKSRWDREDLLTPPENIAIISEQEPEAMRVLLERAVEVDAAVA 321 Query: 222 RRGVEW-----NYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS-------- 268 R G E+ +V GT +++ LPL + A A AL A Sbjct: 322 RAGAEFGAVESTVAVGGQRLTIKGLAGTYDDIFLPLSGEHQARNAATALAAVEAFFGAGG 381 Query: 269 GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLA 328 ++ + +R+G A+ PGR + V +P V D +HNPH A L + R++ Sbjct: 382 DRQLDVDKVREGFATVTSPGRLERVRATPSVFIDASHNPHGAAALAKAVDRDFDFRRLIG 441 Query: 329 VIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNG------KSFDSVA 382 V+ +L DKD G LA L+ V+DD ++ PR + L E+ + + + Sbjct: 442 VVAVLGDKDARGILAALEPVLDDVVITEVQSPRALPVDVLAEYARDAFGEERVHVAEQLP 501 Query: 383 QAWDAAMADAKAEDT-------VLVCGSFHTVAHVMEVIDAR 417 A + A+ A+ + VLV GS T + + Sbjct: 502 TAVETAIQLAEDDSDGMLAGAGVLVTGSVVTAGEARTLFAKK 543 >UniRef50_C4V4R4 Possible tetrahydrofolate synthase n=2 Tax=Selenomonas RepID=C4V4R4_9FIRM Length = 433 Score = 389 bits (999), Expect = e-106, Method: Composition-based stats. Identities = 127/431 (29%), Positives = 196/431 (45%), Gaps = 25/431 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L YL+ L++ I LGL R+ + ARLG + + V +AGTNGKG+ + ++++ Sbjct: 3 YEESLHYLDELNTFGIRLGLARMEELCARLGHPERSYRVIHIAGTNGKGSVTQMMDAVCR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI------ESARGDISLTYFEY 126 A+G + G Y SPHLV YTER+ V G+E+ E A + +A G T FE Sbjct: 63 ASGIRSGRYLSPHLVSYTERMSVGGEEIGEEQFAALLTRVSAAADAMTAEGHEHPTQFEA 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T A F + + +V ++E GLGG LD+TN+V ++ ++T++A+DH D G I Sbjct: 123 LTALAFLYFAEEKAEVAVVETGLGGLLDSTNVVLPELTIITNVAMDHADRCGGTLAGIAE 182 Query: 187 EKAGIFRSEKPAIVGEP-EMPSTIADVAQEKGALLQRRGVEWNYSVT--DHDWAFSDAHG 243 KAGI + P I E S IA A+E GA L G +++ + ++ H Sbjct: 183 HKAGIIKEGVPVITAAAGEPLSIIAARAEELGADLFVYGEDFSAQMLRMENGGQCVSFHS 242 Query: 244 TLENLPLPL-------VPQPNAATALAALRASGLE---VSENAIRDGIASAILPGRFQIV 293 + P P NAA A+ A E ++E+A+R + + P RF+I+ Sbjct: 243 VVSRAPEPFEIALAGPYQAENAALAIMAAELMAPEDERITEDAVRTALRTVHHPARFEIL 302 Query: 294 S-ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 S V+ D AHNP + L + A + ++G+L DKDI LA L D Sbjct: 303 SCGGQTVVVDGAHNPAGMQALRAGLDAYFPAQPRVFLLGILKDKDIDRMLAILLRPGDQV 362 Query: 353 YCAPLEGPRGATAE----QLLEHLGNGKSFDSVAQAW-DAAMADAKAEDTVLVCGSFHTV 407 R A A+ + A +A A+ ++ GS + V Sbjct: 363 VTVRPNSERAAGADLVAAVAAGMGAVTHAAGDPAAGLSEALARAHAADALLVAAGSLYLV 422 Query: 408 AHVMEVIDARR 418 + + A R Sbjct: 423 GGIRTRLLAGR 433 >UniRef50_B3DQR8 Folylpolyglutamate synthase n=18 Tax=Bifidobacterium RepID=B3DQR8_BIFLD Length = 543 Score = 389 bits (999), Expect = e-106, Method: Composition-based stats. Identities = 126/430 (29%), Positives = 205/430 (47%), Gaps = 40/430 (9%) Query: 27 TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 T +L L+R++L+ LG + + V + GTNGKG+T R E+I A G + G+Y+SPHL Sbjct: 29 TTNLDLDRMNLMLDILGHPEQSFRVIHITGTNGKGSTARMAEAICRAYGMRTGLYTSPHL 88 Query: 87 VRYTERVRVQGQELPESAHTASFAEIE----------SARGDISLTYFEYGTLSALWLFK 136 + ER+ + GQ+L + + + + +G +++FE T A+W F Sbjct: 89 EKINERIAIDGQQLSDDDFIDIWDQTKDLVALVDAKMEEQGKPKMSFFEVLTAMAIWKFA 148 Query: 137 QAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEK 196 +DV I+EVG+GG DATN+++AD A++ + +DH WLG E I EKAGI + Sbjct: 149 DTPVDVAIVEVGMGGLWDATNVLNADAAIIGPVDMDHMQWLGDTVEQIATEKAGIIKPNC 208 Query: 197 PAIVGEPEMPST----IADVAQEKGALLQRRGVEWNYS-----VTDHDWAFSDAHGTLEN 247 AI+G +A+ A+ A+L R G E S V + +GT E Sbjct: 209 TAIIGPQPHEEAVMPILAEAAERNHAMLVRDGYEMTVSDRMAAVGGQVATLTTPNGTYEG 268 Query: 248 LPLPLVPQPNAATALAALRASGL------EVSENAIRDGIASAILPGRFQIVSESPRVIF 301 +P+ + A ALAAL AS + + + + + ++S +PGR + + SP +I Sbjct: 269 VPIAKFGEHQAHNALAALAASEVVIPVNGPLDGDLVGEALSSVKIPGRIEQIRTSPTIIL 328 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP-LEGP 360 D HN +AAE L ++ +++ V+ M+ DK + L L+ ++ Sbjct: 329 DGGHNVNAAEALRKAIEESYDFKQLVGVVAMMRDKQVEEYLGVLEPILSSVVVTENSWRE 388 Query: 361 RGATAEQLLEHLGNGKSFDSV------AQAWDAAMADAKAED--------TVLVCGSFHT 406 R A++L + + D V A A+ AED VL+CGSF T Sbjct: 389 RVMPADELEKIAVDVFGRDRVIKEANLPDAIQTAVNMVDAEDELGVGYGHGVLICGSFVT 448 Query: 407 VAHVMEVIDA 416 +++ Sbjct: 449 AGDARLMLEE 458 >UniRef50_C4LJV2 Dihydrofolate synthase / folylpolyglutamate synthase n=68 Tax=Actinomycetales RepID=C4LJV2_CORK4 Length = 538 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 131/465 (28%), Positives = 201/465 (43%), Gaps = 53/465 (11%) Query: 6 TPQAASPLASWLSYLENLHSKT-IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 TP LA L + +T ID L R+ V LG + A VAGTNGK + Sbjct: 72 TPDDLEALADVEDQLNSRWPETKIDPTLYRMHQVLDLLGDPQHAYPSIHVAGTNGKTSVT 131 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE----------S 114 R +ES+L A + G +SPHL TER+ + G+ + + ++ I+ Sbjct: 132 RMIESLLRAFHRRTGRTTSPHLQSVTERIAIDGEPIHPADFVQTWKSIKPFVEMVDRRSE 191 Query: 115 ARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHT 174 G ++ FE T A F A +DV ++EVG+GGR DATN+V DV V+T + +DH+ Sbjct: 192 DEGGPRMSTFEVLTTMAFAAFADAPVDVAVVEVGMGGRWDATNVVHGDVTVITPVGMDHS 251 Query: 175 DWLGPDRESIGREKAGIFR-----------SEKPAIVGE--PEMPSTIADVAQEKGALLQ 221 ++LG E I EKAGI + + AI+ E P + I + A A + Sbjct: 252 EYLGDTIEEIAGEKAGIIKSRWDKDDLLTPPDNVAIIAEQDPAAMNVILEQAVSVDASVA 311 Query: 222 RRGVEW-----NYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS-------- 268 R G E+ + +V GT EN+ LPL A A AL A Sbjct: 312 RAGSEYGVVERSVAVGGQTLTIRGLGGTYENIFLPLSGAYQARNAATALAAVEAFFGAGG 371 Query: 269 GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLA 328 G ++ N +R+G + P R + + SP V D HNP A L + R++ Sbjct: 372 GRQLDINTVREGFGNVSSPARLERIRTSPSVFVDATHNPQGARALAETLHDDFSFRRLIG 431 Query: 329 VIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG------NGKSFDSVA 382 ++ + DKD+ G L L+ D+ ++ PR ++L E S+A Sbjct: 432 IVSIFQDKDVVGVLETLRDTFDEIVVTEVDSPRAMPVDELAELARTLFGDERVHVSASMA 491 Query: 383 QAWDAAMADAKAEDT----------VLVCGSFHTVAHVMEVIDAR 417 A + A+A A+ E V++ GS ++ ++ Sbjct: 492 DAIEDAVALAEEEGEEEGYGLAGTGVVITGSVYSAGRARALLGKE 536 >UniRef50_B3E778 FolC bifunctional protein n=3 Tax=Desulfuromonadales RepID=B3E778_GEOLS Length = 428 Score = 387 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 127/419 (30%), Positives = 190/419 (45%), Gaps = 18/419 (4%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 P + LS L I GLER++ + R G + + V GTNGKG+T L +I+ Sbjct: 2 PASQQLSRLFGRRRFNIKPGLERITALLERHGHPERSFAAIHVVGTNGKGSTAAFLAAII 61 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 AGY G+++SPHLV YTER RV G + P A ++ G T+FE T A Sbjct: 62 EQAGYCTGLFTSPHLVSYTERFRVNGVDCPPEQLEALIPDLLEQAG-PDDTFFELTTALA 120 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 F + ++ + +LE G+GGR DAT V +++ IALDH WLG D +SI EK I Sbjct: 121 CHWFARNKVQLAVLEAGMGGRSDATAAVAGIATIISPIALDHCQWLGNDLQSIAAEKVAI 180 Query: 192 FRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT--DHDWAFSDAHGTLEN 247 R P I V P++ + I + + L G ++N + D F+ + G+L Sbjct: 181 ARPGSPVISAVQPPDVQAVIEEYCRTNNNRLLLAGRDFNATSNGADTGLTFTGSSGSLSG 240 Query: 248 LPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVS--ESPRV 299 L L A L G +S+ A++ G+A+A PGR + + + + Sbjct: 241 LHPSLSGSYQTGNAALALAAAEQLATLGFPISQQAMQAGLATARWPGRLERLRLADGSEL 300 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 + D AHNP A+ R++ ++GM+ DKD+ G L L V Sbjct: 301 LLDGAHNPAGAQA-LAAALQELGKRRIILLLGMMEDKDLQGVLQPLLQRVQQVITVSPAQ 359 Query: 360 PRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 R A +L + DSVA +AA A A D ++ GS V + ++ Sbjct: 360 ERALPATELAARCRTAGTPATAADSVAAGLEAARAAAGPGDLIVAAGSLFLVGELKALL 418 >UniRef50_Q6KZL1 Folylpolyglutamate synthase/dihydrofolate synthase n=3 Tax=Thermoplasmatales RepID=Q6KZL1_PICTO Length = 435 Score = 387 bits (995), Expect = e-106, Method: Composition-based stats. Identities = 121/419 (28%), Positives = 197/419 (47%), Gaps = 26/419 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + + L+YL L + I LGL+ A LG + +AGTNGKG+ + +IL Sbjct: 1 MDNILNYLYELKREGIKLGLDTTRAFAEHLGNPQDKYKKIHIAGTNGKGSISSYIYNILR 60 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAE----IESARG-DISLTYFEYG 127 Y G+Y+SPHL+++ ER+ + + + +E I+ ++ T+FE Sbjct: 61 QR-YNTGLYTSPHLIKFNERIIFNKEMISDDYIINFISENRDYIDKLSKIKMNPTFFETT 119 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T+ A F D +EVGLGGRLD+TNI+ +++++ I +H LG SI E Sbjct: 120 TVMAFKYFYDMHADYAAIEVGLGGRLDSTNIIIPEISIIGQIGYEHYQKLGCSLTSIAYE 179 Query: 188 KAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS------ 239 K GI + P ++ + PE+ + I ++Q + + L +++ S + F Sbjct: 180 KGGIIKPGIPVVLQDKKPEVLAEIKKLSQVRKSKL-ILSEDYSKSTEPELYNFKMVFDLK 238 Query: 240 --DAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 +E+ L L N TA+AAL ++++ + GI AI GR +I+ SP Sbjct: 239 TPLNEYHIESNNLGLYQVKNIKTAVAALENMDTSINKHDVESGIDKAIWHGRMEIIRASP 298 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 VI D AHNP AA L K K + L +IGML DKD+ L ++ + D Sbjct: 299 LVIIDSAHNPPAASNLVPSFKKFIK-KKPLLLIGMLSDKDVFSFLTIMRQLSDKIVLTMP 357 Query: 358 EGP-RGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 P R + + + + K A+D ++ ++ D VLVCGS + + +M Sbjct: 358 NEPDRALDPDNIKDIASSIYRDVKIIKDPLSAYDYSLKNS---DCVLVCGSMYLIGDIM 413 >UniRef50_Q2NZP7 Folylpolyglutamate synthase n=19 Tax=Xanthomonadaceae RepID=Q2NZP7_XANOM Length = 432 Score = 387 bits (995), Expect = e-106, Method: Composition-based stats. Identities = 190/425 (44%), Positives = 258/425 (60%), Gaps = 22/425 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + L+ WL+Y+E H +I +GLERV VAARL + PA V GTNGKG+T +E+I Sbjct: 5 TTLSEWLAYIEQQHPSSIAMGLERVREVAARLQIAAPAKHAIVVGGTNGKGSTVAFIEAI 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 AAG+K+G Y+SPHL+RY ERVR+ G+E ++ +FA +E+ARGD +LTYFE+GTL+ Sbjct: 65 GRAAGWKIGAYTSPHLLRYNERVRIDGEEASDAQLVDAFAAVEAARGDTALTYFEFGTLA 124 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 ALWLF+ A LD+ +LE+GLGGRLDA NIVDADVAV+T++ +DHTDWLG DRE+IG EKAG Sbjct: 125 ALWLFQSAALDLTVLEIGLGGRLDAVNIVDADVAVITTVDIDHTDWLGEDREAIGTEKAG 184 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH-----------DWAFS 239 I R+ KP ++GE + PS++ A + GA R G ++ + + W + Sbjct: 185 IMRAWKPVVLGEIDPPSSVLRRAYQLGANAIRAGSDYFFEPIEVQHPENPQSDAPQWRWR 244 Query: 240 DAHGTLENLPLPLVPQP----NAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSE 295 D TLE LP+P + P NAA A+AAL+A +EV A GI +A + GR Q ++ Sbjct: 245 DVAVTLE-LPMPALHAPVQLANAAAAIAALQALPVEVPAAAWVQGIGNAQVAGRLQRLAV 303 Query: 296 SPR-VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 V+ DV HNP AA L + A G A+ L DKD+ G + + + +D W Sbjct: 304 DGLQVLLDVGHNPQAARALAAALGAQAHAGSTYAIYAALADKDVVGVVEAVAAQIDHWAL 363 Query: 355 APLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 A LEG RG +A+ L L VA A +A +A A D VLV GSFHTVA Sbjct: 364 AGLEGARGQSAQALHARLQGTAAAQALCHRDVASAVEAVLATASPGDRVLVFGSFHTVAD 423 Query: 410 VMEVI 414 + + Sbjct: 424 ALSAL 428 >UniRef50_B1ZVD5 FolC bifunctional protein n=4 Tax=Verrucomicrobia RepID=B1ZVD5_OPITP Length = 440 Score = 387 bits (995), Expect = e-106, Method: Composition-based stats. Identities = 135/431 (31%), Positives = 209/431 (48%), Gaps = 31/431 (7%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P AA+ + YL L + LGL+R+ L+AA LG + A VAGTNGKG+ Sbjct: 15 PDAAAGFEAVAEYLCGLKAGGSKLGLDRMRLLAAELGHPERALRCVHVAGTNGKGSVAAM 74 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------ 120 LE+IL AAG++VG+++SPHLV ERV+V Q L + E++ I+ Sbjct: 75 LEAILRAAGWRVGLFTSPHLVHVGERVQVNRQPLAPAEIVGYVRELDVLADRIAAREGPG 134 Query: 121 --LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLG 178 ++FEY T AL F + + D+ ++EVGLGG DATN+VD ++ V+TSI DH +WLG Sbjct: 135 DRPSFFEYMTAMALLQFGRQRCDIAVMEVGLGGEFDATNLVDPEMTVITSIGFDHCEWLG 194 Query: 179 PDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDW 236 E I R KAGI + E+P ++G P + I A+E A + + ++ + Sbjct: 195 HTLEEIARAKAGIIKPERPVVIGRVPPAAETVIRARAEEMEARVISVREVYGENLA--VY 252 Query: 237 AFSDAHGTLENLPLPLVPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVS 294 ++ G + NAATA A R +SE AI G+ PGR+Q V Sbjct: 253 PETNLAGDY--------QRWNAATATLAARELDSRWRISERAIAHGLWHVRWPGRWQRVL 304 Query: 295 ESP-RVIFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 RVI D +HN A L + L + V+G+L + +A + + Sbjct: 305 VGGRRVILDASHNAEGASVLDANLARLRAETGRAPIVVVGVLGAERAQPLMAAICRHAGE 364 Query: 352 WYCAPLEGPRGATAEQLLEHLGNG----KSFDSVAQAWDAA--MADAKAEDTVLVCGSFH 405 + PR ++ E+L + G + +VA+ + A +D++++ GS + Sbjct: 365 VHLVVPNQPRASSYEELAALIPAGFPGRVARTTVAEIFPGGDHCALGGPDDSIVITGSIY 424 Query: 406 TVAHVMEVIDA 416 + V+ I A Sbjct: 425 LLGEVLPRIGA 435 >UniRef50_Q0BQJ2 Folylpolyglutamate synthase n=2 Tax=Acetobacteraceae RepID=Q0BQJ2_GRABC Length = 430 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 133/420 (31%), Positives = 205/420 (48%), Gaps = 27/420 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESILMAAG 75 + L LH K IDL L R+ + +LG + + P V VAGTNGKG+TC L ++ AAG Sbjct: 10 IERLHGLHPKMIDLSLGRLEALLEKLGHPERSLPPVVHVAGTNGKGSTCAFLRALAEAAG 69 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 +V VY SPHLV++ ER+R+ G+ + E + E+E +T FE T AL LF Sbjct: 70 QRVHVYISPHLVQFNERIRLAGELVSEPVLVEALEEVERVNAGAPITVFEVITAVALLLF 129 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 + D+ ++EVGLGGR DATN+V V+ + SI++DH ++LG D I EKAGI +S Sbjct: 130 SRVPADLCVVEVGLGGRFDATNVVTPVVSAIASISIDHREYLGDDIRGIAAEKAGILKSG 189 Query: 196 KPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV 253 P + G P++ + A ++G L R +W+ + +SD G + +LPLP + Sbjct: 190 APGVTGLQLPDVLEVLDREAAKQGVSLLARDRDWHIARRGDGLRYSDPDGVV-DLPLPAL 248 Query: 254 P-QPNAATA------LAALRASGLEVSENAIRDGIASAILPGRFQI--------VSESPR 298 P + A + A + L +S A +G+A A P R Q + + Sbjct: 249 PGEHQLDNAGIAVAAMRAAAKTALPLSWRA--EGLARAEWPARMQRLTGLLAKDLPDGWE 306 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 + D HNP A L G ++ K+ ++GM KD LA + D + Sbjct: 307 LWLDGGHNPGAGVMLAGHLRGW-KDRPAHVIVGMKQAKDAGQFLASVLPEADTVWAIAEP 365 Query: 359 GPR-GATAEQLLEH-LGNGKSFDSVAQAWDAAMADAKAE---DTVLVCGSFHTVAHVMEV 413 G E ++ G +V QA A + A+A +L+CGS + ++++ Sbjct: 366 GQYLALPVEAIVSASGGKAIPGPTVRQAMAAILKQAEAGSIPGRILICGSLYLAGEILKL 425 >UniRef50_B0TC04 Folylpolyglutamate synthase n=5 Tax=Clostridia RepID=B0TC04_HELMI Length = 459 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 121/448 (27%), Positives = 196/448 (43%), Gaps = 44/448 (9%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKP--APFVFTVAGTNGKGTTCRTLES 69 L+YL++L + GL R++ + RLG P + GTNGKG+T + Sbjct: 9 SYDDALAYLKDLTKFGFNFGLGRITELLRRLGEPHRKKRPAFIHIGGTNGKGSTSVMTAA 68 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTY 123 +L AAG++VG+++SPHL YTER R+ G+ +P+ A AE+ A G T Sbjct: 69 VLQAAGHRVGLFTSPHLHCYTERTRINGKPIPKETMAALIAELRPHLEAMVAGGFEHPTE 128 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T +L F + +DVV+LEVGLGG +D+TN+V VA +T+++ DH D+LG Sbjct: 129 FEVWTALSLLYFAREAVDVVVLEVGLGGSIDSTNVVTPIVACITNVSFDHMDYLGTTLPE 188 Query: 184 IGREKAGIFRSEKPAIVGEPEM--PSTIADVAQEKGALLQRRGVE------------WNY 229 I KAGI ++ P + + + + + AQ GA + + + + Sbjct: 189 IAAVKAGIVKAGVPLVTASDDAAVLAVLREKAQRLGAPIIQVLRQGPRLPSATPVRWYPV 248 Query: 230 SVTDHDWAFSDAHGTLENLPLPL---VPQPNAATALAALRAS---GLEVSENAIRDGIAS 283 + G L PL Q N ATA+A L A+ G + + + G+ Sbjct: 249 TARRAGILVEGRFGIYGPLTPPLSGRHQQANLATAVAVLEAAKEKGFDWRADHLEAGLGQ 308 Query: 284 AILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA 343 PGR + + + D AHN A L ++ G+ + V+GML DK+ + Sbjct: 309 VSWPGRLERIG---PFLLDGAHNVAGALSLAAALRE-EGAGKYVFVLGMLADKERERVVD 364 Query: 344 WLKSVVDDWYCAPLEGPRGATAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAED--- 396 L + PR + L + + +A + A A+ + Sbjct: 365 ILAPLAKAIIVTRPNSPRAGEWQALASLAARRCDSVTVVSDIGEALEMARLSAQDPEKAD 424 Query: 397 -----TVLVCGSFHTVAHVMEVIDARRS 419 ++V GS + VA +I + + Sbjct: 425 GEGHAPIVVTGSLYMVAEARGIILSCEN 452 >UniRef50_C4Z2M8 Folylpolyglutamate synthase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z2M8_EUBE2 Length = 427 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 100/428 (23%), Positives = 191/428 (44%), Gaps = 24/428 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + L ++ G++R ++ + + + VAGTNGKG+ C + IL Sbjct: 2 YDEIIDRLNSIGQFASSSGVQRAEILLRDMNNPEEKLNIIHVAGTNGKGSVCAYIAQILQ 61 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 GYK G+++SPHLV ER+R+ + + + ++ +E L YF+Y A+ Sbjct: 62 ENGYKTGLFTSPHLVDVRERIRINNEMISKEDFVEAYEYVEEHHSG-ELAYFDYLFGMAV 120 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 + + + +D V++E GLGGRLDATN V ++V+++I+L+HT LG E I EKAGI Sbjct: 121 YYYNRQNVDYVVMETGLGGRLDATNAVKQPLISVISTISLEHTAILGDTIEKIATEKAGI 180 Query: 192 FRSEKPAIVG--EPEMPSTIADVAQEKGA---LLQRRGVEWNYSVTDH-DWAFSDAHGTL 245 + P + + + I ++A + + +L E + + D+ + + Sbjct: 181 IKPGIPVVCSGVDKHAANVIKEIASDNSSACIVLDENSYELKQNTYGNIDFLIHNEYYKN 240 Query: 246 ENLPL---PLVPQPNAATAL---AALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 + L L NA+ AL A L+ SG+++ + ++ ++ GR + V E+ + Sbjct: 241 DCFRLATNALYQIENASIALTVCAVLKDSGVKLDDRLTKEAVSKTHWAGRMEPVKEN--L 298 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRV---LAVIGMLHDKDIAGTLAWLKSV--VDDWYC 354 D AHNP + +L ++ + + ++ DK+ + L Y Sbjct: 299 YVDGAHNPQGIRSFVDSVNSLYESEELSDATLLFSVVSDKNYEQMIKILCECKHFKHIYV 358 Query: 355 APLEGPRGATAEQLLEHLGNGKSFDSVA--QAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 G R ++E + + S S+ + D + + + GS + V V+ Sbjct: 359 TMTGGARRLSSEIIKQTFEVYLSGISIEISDSVDRVIHEWD-NGLMFATGSLYLVGDVVR 417 Query: 413 VIDARRSG 420 ++ + + Sbjct: 418 ALERKENN 425 >UniRef50_B4RCL3 Bifunctional dihydrofolate synthase/folylpolyglutamate synthase n=4 Tax=Caulobacteraceae RepID=B4RCL3_PHEZH Length = 444 Score = 386 bits (993), Expect = e-106, Method: Composition-based stats. Identities = 127/419 (30%), Positives = 191/419 (45%), Gaps = 25/419 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESILMAAG 75 + L H IDL RV + A L + P V VAGTNGKG+T L +I AAG Sbjct: 18 IQRLRRSHPTLIDLTTGRVERLLAALDHPERRLPPVIHVAGTNGKGSTVAYLRAIGEAAG 77 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLF 135 +V +SPHLVR+ ER+R+ G+ + + A +E+A D +++FE T+ AL F Sbjct: 78 LRVHTLTSPHLVRFAERIRLAGRLISDEQLLALTERVEAANADQPISFFEITTVLALLAF 137 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKAGIFRS 194 + D+ ++EVGLGGR DATN+ DA V+V+T + DH + LGP I EKAGI + Sbjct: 138 AETPADLCVVEVGLGGRFDATNVFDAPAVSVITPVDYDHLEMLGPGLAKIAWEKAGIIKR 197 Query: 195 EKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLP- 251 +P +V E I A ++ A + G +++ L +LP P Sbjct: 198 GRPVVVARQLDEALEMIEREADDRMAPMLLMGRDFDAWEERGRLLVQMPE-RLLDLPPPS 256 Query: 252 ---LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR---------- 298 NA A+AA ++ + + DG+ASA+ P R Q ++ P Sbjct: 257 LFGGYQFANAGLAVAAALTFDHDLPDEVLGDGVASAVWPARMQRLTAGPLFELARARGAD 316 Query: 299 VIFDVAHNPHAAEYLTGRM-KALPKNGR-VLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 + D HNPHA L + + ++ R + V GM KD G + Sbjct: 317 IWLDGGHNPHAGRALAEAASRIVDRDPRPLTLVAGMFARKDAEGFFRPFAEMKPRVIATT 376 Query: 357 LEGPRGATAEQLL----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 + P+ A+AE + + + +V A A++ VLVCG H V+ Sbjct: 377 FDSPQAASAEDIAVAAVKAGLPAEMSPNVEDAVRRALSVDGPAPHVLVCGGLHFAGEVL 435 >UniRef50_B1H0E2 Folylpolyglutamate synthetase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1H0E2_UNCTG Length = 421 Score = 386 bits (993), Expect = e-106, Method: Composition-based stats. Identities = 105/412 (25%), Positives = 181/412 (43%), Gaps = 22/412 (5%) Query: 25 SKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSP 84 + + GL R+ + + +AGTNGKG+T + IL A GYK +YSSP Sbjct: 9 YEGMTPGLSRIKKFFKSIDNPQNKLKAVHIAGTNGKGSTAAFISEILKAGGYKTALYSSP 68 Query: 85 HLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVI 144 HL+ TER+++ G+ +P + L+YFEY T A F + + D+ + Sbjct: 69 HLIDITERIKIDGENIPSKIFNGLSKKYLERAVKYKLSYFEYLTALAFIYFAEQKTDIAV 128 Query: 145 LEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEP 203 +E GLGGR DATN++ + +TSIA +H + LG + E I EKAGI + + + G+ Sbjct: 129 IETGLGGRFDATNVIKKPLICAITSIAKEHQEILGAETEKIAFEKAGIIKGDAYVVCGK- 187 Query: 204 EMPSTIADVAQEKGALLQRRGVEWNY-----SVTDHDWAFSDAHGTLENLPLPLVPQPNA 258 +P V + K G + S + + ++ + L+N+ + L+ + A Sbjct: 188 -LPKRAITVIKNKSNPYYLYGKDLKVANNKSSRSRQKFDYTSKNAELKNIEIGLLGRHQA 246 Query: 259 ATALAALRASGLE------VSENAIRDGIASAILPGRFQIV-----SESPRVIFDVAHNP 307 A A+ A+GL +SE IR G+ +A+ GRF I +++ +I D AHN Sbjct: 247 VNASIAIFAAGLLNKKGYYLSEAHIRTGLKNAVWQGRFDIRKIHSNNKNFELIIDGAHNI 306 Query: 308 HAAEYLTGRMKAL-PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 + L + + + ++ +K + S + R E Sbjct: 307 QGLNAFFETFEQLGFSKKKRIFIFTVMKEKKYKYMVKKTASFAKKVILPRINNDRALNPE 366 Query: 367 QLLEHLGNGKSFDSVAQA--WDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 L + + + + A A A +T + GS + V +++ I+ Sbjct: 367 VLKKEFSKYIAQNKICTADSVKNACAMISDNETSVAVGSLYLVGEILKYINE 418 >UniRef50_Q97AP2 Folylpolyglutamate synthase n=2 Tax=Thermoplasma volcanium RepID=Q97AP2_THEVO Length = 407 Score = 386 bits (992), Expect = e-106, Method: Composition-based stats. Identities = 122/408 (29%), Positives = 194/408 (47%), Gaps = 25/408 (6%) Query: 35 VSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVR 94 + A LG + + G+NGKG+T + SIL + VGVY+SPHL R+ ER+ Sbjct: 2 MREFADMLGHPERDFRSIHITGSNGKGSTSAFIYSILRQK-FSVGVYTSPHLERFNERII 60 Query: 95 VQGQELPESAHTASFAEIESARGDIS-----LTYFEYGTLSALWLFKQAQLDVVILEVGL 149 V +E+P+ + ++S T+FE T+ A FK ++D +EVGL Sbjct: 61 VDNEEVPDEYIDGFIEKYRPKFDELSKVNRNPTFFEVTTMMAFQYFKDRKVDYASVEVGL 120 Query: 150 GGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PEMPS 207 GGRLDATNI+ +V+V+ + +H D LG SI EKAGI + +P ++ + PE+ + Sbjct: 121 GGRLDATNIIMPEVSVIAQVGYEHADKLGCSLTSIAYEKAGIIKEGRPIVLQDDKPEVVN 180 Query: 208 TIADVAQEKGALL------QRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATA 261 + +AQ K + L + + + + + TD D+ ++ + + NAATA Sbjct: 181 EVRRIAQVKHSPLITLDRNKIKNLHVDENGTDFDFDGTNDTYHIHTSLIGDYQALNAATA 240 Query: 262 LAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALP 321 + A+ S ++V + I GI+ I PGR +I+ SP VI D AHNP AA + +K + Sbjct: 241 ILAVENSKVQVYKKDIETGISRTIWPGRLEIIDRSPLVIIDAAHNPPAANKMVRTVKKVF 300 Query: 322 KNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-PRGATAEQLLEHLGN----GK 376 N V G+L DKD + L+ + E R L+ GN + Sbjct: 301 -NREPTIVAGILSDKDAYSFFSVLRQLSGKIIFTTPEEKERAVDPNILMAQYGNLFRSAR 359 Query: 377 SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA--RRSGGK 422 A++ A +D V V GS + + + + D + G K Sbjct: 360 VIPDPISAFEHAKKV---DDFVFVTGSIYLIGVIRGLYDKANEKKGTK 404 >UniRef50_B5Y836 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y836_COPPD Length = 417 Score = 385 bits (991), Expect = e-105, Method: Composition-based stats. Identities = 116/408 (28%), Positives = 180/408 (44%), Gaps = 24/408 (5%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 L L R+ + LG+ + V GT+GKG+ C L SIL YKVG Sbjct: 12 LNQAPWFGRTPDLTRMDALLDELGLPQANTKNIIVTGTDGKGSVCSYLHSILGRR-YKVG 70 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG------DISLTYFEYGTLSALW 133 + SPHL +TER+ V ++ + + ++ T FE AL Sbjct: 71 RFISPHLEEWTERITVGKDDISKEDFARLYVKVMEGAKKACRVSGEMPTVFERLLAMALL 130 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F++ + ++EVG+ G D+TN++ A VVTS+ +DH LG E I + FR Sbjct: 131 YFEEQGTEWNVIEVGIEGHYDSTNLLPAKAVVVTSVGMDHMRLLGNTIEEIADAISAAFR 190 Query: 194 SEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE-NLPL 250 A++G +P + + A+ K A + R G ++ Y D F G+L+ L L Sbjct: 191 PHAVAVIGKTDPAAMNILEVNARRKKATVYRYGRDFWY-----DGKFLSYSGSLDFQLAL 245 Query: 251 PLVPQPNAATA----LAALRASGLE-VSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 V Q A+A + AL ++ L + + I++G+ A PGR + V E+P +I D AH Sbjct: 246 RGVHQWYNASAAIQTVLALSSTELNNIDASDIQEGLREAFWPGRMETVRENPLIILDGAH 305 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATA 365 NPHAA+ L + L + + DKD L + + Y + R + Sbjct: 306 NPHAAQSLRTSLDLLYPGKKWNIFFAAMKDKDWRSVLTQFLDLANHVYVVRMPYERAESP 365 Query: 366 EQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 E ++E L + SV + D D A LV GS + V V + Sbjct: 366 ETIVEFLKEKGTSSSVCEEQDVIKCDEDA----LVFGSLYLVGDVRRL 409 >UniRef50_A1ZCQ8 Folylpolyglutamate synthase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZCQ8_9SPHI Length = 428 Score = 385 bits (991), Expect = e-105, Method: Composition-based stats. Identities = 118/426 (27%), Positives = 190/426 (44%), Gaps = 22/426 (5%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 Q L L +N+ K + L+ + A LG +AGTNGKG++ Sbjct: 2 TYEQTLDYLYKQLPIFQNIGGKAFNASLDNIRRFCAHLGNPHTQYPTLHIAGTNGKGSSS 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L ++L AAGYKVG+Y+SPHL +TERVRV GQ + + A ++ ++F Sbjct: 62 HMLAAVLQAAGYKVGLYTSPHLKSFTERVRVNGQAIAPAQIVAFVQRYQTQIESWRPSFF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E AL F Q ++DV ++EVGLGGRLDATNIV + ++T+I+ DH LG ++I Sbjct: 122 EVTVAMALDYFAQQKVDVAVIEVGLGGRLDATNIVTPEACLITNISFDHQQILGNTLKAI 181 Query: 185 GREKAGIFRSEKPAIVGEPEMPS--TIADVAQEKGALLQRRGVEWNYSVTDHD----WAF 238 +EKAGI + P ++GE + + +Q+ A L E+ D Sbjct: 182 AKEKAGIIKLNTPVVIGERQTETTPVFETTSQQHQAPLYFAQDEYFCKWADVAQGKLMVK 241 Query: 239 SDAHGTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIAS----AILPG 288 + L + + L L L+ ++++ I +G+ L G Sbjct: 242 KNGKAFLPEITMSLKGSYQEKNINGVLKVLEILQNRDWQITQEHIIEGLQKTVELTQLKG 301 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 R+Q++ ++P I D AHN + ++ V+G + DK + L L + Sbjct: 302 RWQVLKKAPLTICDTAHNEAGLSQVM-TQLQQLPRQQLHIVLGAMADKVLDKIL-PLFPM 359 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSF 404 +Y PR +L + G ++ SV +A+ A + A+ D V GS Sbjct: 360 EATYYFCAPAIPRAMEVNKLKQLAAGFELRGLAYASVMEAYTQAQSQAQINDVVFAGGST 419 Query: 405 HTVAHV 410 +A + Sbjct: 420 FVLAEI 425 >UniRef50_A0Z5L0 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=marine gamma proteobacterium HTCC2080 RepID=A0Z5L0_9GAMM Length = 427 Score = 385 bits (991), Expect = e-105, Method: Composition-based stats. Identities = 143/414 (34%), Positives = 213/414 (51%), Gaps = 13/414 (3%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 A L +WL++LE LH + IDL L RV VA +LG+L TVAGTNGKG+ L + Sbjct: 6 AETLDAWLTHLETLHPQKIDLELTRVKTVAHQLGLLPAGCRTVTVAGTNGKGSCVSALSA 65 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 +L G VG Y+SPHL+ + ER+ + G ++ +FA IE R ISL+YFE+ TL Sbjct: 66 LLRQKGLSVGCYTSPHLLTFNERITINGIPASDAEIMGAFALIEERRAAISLSYFEFATL 125 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +AL LF++ + V ILEVGLGGRLDA N+VDAD V+TSI +DHT+WLG R+ I EKA Sbjct: 126 AALLLFQEKGVAVQILEVGLGGRLDAVNMVDADACVITSIGIDHTEWLGDTRDLIAIEKA 185 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 G+ R KPA+V E ++P T+ + GA + +W S + + GT LP Sbjct: 186 GVARLGKPAVVAESDLPLTLLPTLEALGANVAALDRDWLIS----EQMLTLPDGTQRLLP 241 Query: 250 -LPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGR-FQIVSESPRVIFDVAHNP 307 +P + N A+ A + ++ I + +PGR Q+V+ DVAHN Sbjct: 242 TVPGLQTSNLGAAVVAAMKLNVTPDQDCIDKAFLALSVPGRQQQLVAMDRLWWLDVAHNC 301 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-PRGATAE 366 + L + + A+ G + DK + + + + W+ EG R A Sbjct: 302 ESVARLAAAIAEKTGGVQTHAIFGAMADKPLRAMIELISEGISSWHLPAHEGIARAANPA 361 Query: 367 QLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 L + + + + + A++ +K D ++V GSF TV + + Sbjct: 362 DLAQLIKRISPKATVQCYPTPESAFNGIENVSKPGDRIVVFGSFVTVGAQLACL 415 >UniRef50_C1CYP7 Putative tetrahydrofolate synthase (Folylpolyglutamate synthase) n=2 Tax=Bacteria RepID=C1CYP7_DEIDV Length = 435 Score = 385 bits (991), Expect = e-105, Method: Composition-based stats. Identities = 135/414 (32%), Positives = 195/414 (47%), Gaps = 14/414 (3%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 A L + L +L + + GL RV + RLG + A V V GTNGKG+T +L Sbjct: 16 ACVRLEADLEWLFSRQRFGMHPGLTRVHSLLTRLGEPQRAFRVVLVGGTNGKGSTAASLA 75 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 S+L A G +VG+++SPHL R+ ER V G+ LP+ S ++ I ++FE T Sbjct: 76 SMLRAQGRRVGLFTSPHLTRFAERFVVGGELLPDDVVLRSLHQVRPHAEAIEASFFEIVT 135 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 +F +A + ++EVGLGGRLDATN +D ++V+T++ALDHT+ LG E I EK Sbjct: 136 ALGCLVFAEAGVQDAVMEVGLGGRLDATNALDPVLSVITNVALDHTEVLGNTVELIAAEK 195 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQR---RGVEWNYSVTDHDWAFSDAHGTL 245 AGI R +PA+ G P + + +GA L R + G Sbjct: 196 AGILRPGRPAVTGA--APDV-WPMLEAEGADLWSLENRVRRQSLGWDGEQVVVRLPAGVE 252 Query: 246 ENLPLPLVPQPNAATALAALRAS-GLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDV 303 PL+ A A A A+ L VS AI G + PGR ++++ RV+ D Sbjct: 253 LTFRTPLLGAHGAQNAALAAAAAYRLGVSPEAISRGAQTTQWPGRMEVLTVGEGRVLLDG 312 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE-GPRG 362 AHNP AE + ++ L G++ V G DKD++G A L+ V PR Sbjct: 313 AHNPAGAEAVVRALRDL-GVGKLPLVFGAAADKDLSGVAAALEPVASQVVLTRARLSPRS 371 Query: 363 ATAEQLLEHLGNGKS--FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 A L + +S QA A A LVCGS + + V ++ Sbjct: 372 ADPAALAPLFPGHQVTLTESPEQAIAALRALGAP--LALVCGSLYLIGEVRPLL 423 >UniRef50_Q6MAP9 Putative folylpolyglutamate synthase n=1 Tax=Candidatus Protochlamydia amoebophila UWE25 RepID=Q6MAP9_PARUW Length = 410 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 127/416 (30%), Positives = 198/416 (47%), Gaps = 39/416 (9%) Query: 12 PLASWLSYLENLHSKT-IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 P + + L L+ I LGL + L + VAGTNGKG+ + S Sbjct: 2 PYSELIQRLFALNLHGGIKLGLSNCEKLQTILKFPDHSFSSIHVAGTNGKGSVVAKIASA 61 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI--ESARGDISLTYFEYGT 128 L AGY+VGVY+SPH+ + ER+RV G + E+ +++ +A+ I T+FE T Sbjct: 62 LEYAGYRVGVYTSPHISSFRERIRVNGIMISEADVEKILSQLFNLTAQYSIPATFFELTT 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 AL F + ++D +LE GLGGRLDATNIV ++++TSI+LDHTD LG E+I +EK Sbjct: 122 FLALVYFSREKVDFAVLEAGLGGRLDATNIVSPVLSIITSISLDHTDILGDTLEAIAKEK 181 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 AGI +S P I+G I +A +K + + +++ + F Sbjct: 182 AGIIKSHTPVIIGPQTPYLFIEKLAYQKNS--------FCHTIKNQFLLFD--------- 224 Query: 249 PLPLVPQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 Q N A A +L ++ + AI G+ A P RF+I++ S VI DVAHN Sbjct: 225 ------QENNAIAKKSLEVLSENWDIPQEAIFKGLE-AKQPCRFEIINNS--VILDVAHN 275 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 P L + + N + + G+ KD+ G L L ++ RG + + Sbjct: 276 PSGLTSLFAKTQTHFPNQPLRILFGLSKGKDLEGCLKILSRHGSAFHLVEAPNGRGISFD 335 Query: 367 QLLEHLGNGKSFDSV-------AQAWDAAMADAK-AEDTVLVCGSFHTVAHVMEVI 414 L + L N +V + A+ A+ + +L+CGSF ++ V + + Sbjct: 336 LLKQGLMNTGIASTVIYSHINIQEGVKIAIKQAESSGQLLLICGSFFIMSQVRQAL 391 >UniRef50_B7ARH5 Putative uncharacterized protein n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7ARH5_9BACE Length = 446 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 119/441 (26%), Positives = 195/441 (44%), Gaps = 44/441 (9%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 + ++ ++ G E + ARLG + V +AGTNGKG+ C + +L + Sbjct: 4 EEAVEHINSVSRYGNRPGAECTKALLARLGNPERELKVIHIAGTNGKGSVCMYIAGMLRS 63 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYG 127 G GV++SPHL+R ER+R + + + T F ++ A ++ ++YF++ Sbjct: 64 LGLNTGVFTSPHLIRENERIRFNDELISDEDFTDCFEKVHRAELELLKDGFGQISYFDFF 123 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESIGR 186 A+ + + DVVILE GLGGRLD+TN V++ V V+TSI+LDH LG E I Sbjct: 124 VGIAMLYYAMKKPDVVILETGLGGRLDSTNAVESPVMTVITSISLDHVAILGDTVEKIAA 183 Query: 187 EKAGIFRSEKPAI-VGEPEMPSTIADVAQEKGALLQRRGVEWN----YSVTDHDWAFSDA 241 EKAGI + P + V E I + A+ G ++ GVE + + + FS Sbjct: 184 EKAGIIKHGAPVVYVAGQEYSHVIEEKAEAMG--IKAAGVEKSQCEIHEIGSKHIDFSLD 241 Query: 242 HGTLENLPLPL-----VPQPNAATALAALRAS-----GLEVSENA---------IRDGIA 282 ++ L NAA A+ A++ ++ ++ IR G+ Sbjct: 242 SIYYKDNVFRLATPAVYQVMNAALAMTAVQMLVESRCFDRIAYDSMDRQNYIDRIRRGLE 301 Query: 283 SAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAV--IGMLHDKDIAG 340 S GR + V E D AHNP L A+ KN R V ++DKD + Sbjct: 302 SVTWEGRMEQVCEG--FYIDGAHNPDGIAALLDTAAAMKKNTRGHYVLMFSAVNDKDYSS 359 Query: 341 TLAWL--KSVVDDWYCAPLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAK 393 + + ++ D++ +EG R ++ + G+ V QA ++ Sbjct: 360 MIKEICDSNIFDEYVITQIEGARCLDVSKIADTFRRYTDGHVNEEPDVGQAVKKSVECFG 419 Query: 394 AEDTVLVCGSFHTVAHVMEVI 414 TV+ GS + V +V+ Sbjct: 420 GNATVICAGSLYLAGEVRKVM 440 >UniRef50_Q3ZAH8 Folylpolyglutamate synthetase n=5 Tax=Dehalococcoides RepID=Q3ZAH8_DEHE1 Length = 439 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 122/418 (29%), Positives = 183/418 (43%), Gaps = 30/418 (7%) Query: 32 LERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTE 91 L RV + RL +AGT GKG+T + S++ AAGY+ G+Y+SPHL+ + E Sbjct: 19 LRRVVELLLRLHSPHIGIPSVHLAGTKGKGSTAALIASVMSAAGYRTGLYTSPHLLDFRE 78 Query: 92 RVRVQGQELPESAHTASFAEIESARGDI-------SLTYFEYGTLSALWLFKQAQLDVVI 144 R+R+ G+ + ++ I ++ +T FE T+ A F + Q + Sbjct: 79 RIRLDGKMISKAHLVRIMDYISPMVEEMNARTCLGKITSFEVMTVLAFEFFHRQQAFFQV 138 Query: 145 LEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--E 202 +E GLGGRLDATN++ +++V+T I+LDHT+ LG I EKAGI + P + Sbjct: 139 IETGLGGRLDATNVITPNLSVLTPISLDHTEVLGDSLAKISAEKAGIIKHFVPVVSAAQR 198 Query: 203 PEMPSTIADVAQEKGALLQRRGVEWN-----YSVTDHDWAFSDAHGTLENLPLPLV---P 254 PE + I + + G+ L + Y+ S L LPL+ Sbjct: 199 PEAMAVIRERCLKTGSKLIEVTDSYKAELLGYTAQGQSLKLSGRQAEYR-LCLPLLGHYQ 257 Query: 255 QPNAATALAALRAS---GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAE 311 + NA TALA+L A G ++S I +G PGRF+++ P ++ D AHN AA Sbjct: 258 RQNALTALASLEALVEEGFKISNEDIAEGFGQVRWPGRFKVIKGKPLMVIDGAHNQEAAA 317 Query: 312 YLTGRMKALPK-----NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 L ++ P + L V G DKD L PR + Sbjct: 318 ELLLSLQEYPPAAKVEKEKRLLVFGTSFDKDAGAMADVLSGYFGTVILTHSLHPRAMKPD 377 Query: 367 QLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSG 420 L + D V +A + A A A+ V V GS A ++ RSG Sbjct: 378 LLRKAFDGRGLKVLEADGVPKALELAGRIAPADGLVCVAGSLFVAAEALKGQSQPRSG 435 >UniRef50_A5EVX7 Folylpolyglutamate synthase n=2 Tax=Cardiobacteriaceae RepID=A5EVX7_DICNV Length = 422 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 148/413 (35%), Positives = 215/413 (52%), Gaps = 19/413 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+ WL++ EN H KT DLGLER+ V +LG K A + TVAGTNGKG+ +E+I + Sbjct: 10 LSEWLAWQENAHPKTWDLGLERIGRVWQQLGAPKIAEHIITVAGTNGKGSCVAWVEAICL 69 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 A G V ++SPH++ Y ER+R + E+ A+F I+ ARG I+LT+FE+ L+A Sbjct: 70 AHGISVASFTSPHVIDYRERIRFNDHMVRETELCAAFEAIDRARGTITLTFFEWSALAAF 129 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +L Q + +LEVGLGGRLDA N++DAD + + I LDHTDWLG + I EKAG+ Sbjct: 130 YLMAQRPPHIAVLEVGLGGRLDAVNLLDADAVIFSRIGLDHTDWLGDHIDKIAAEKAGVL 189 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 R+++ + + + +AD + A L + + + AH +LPLP Sbjct: 190 RAKQWVAMAAEQPTNVLADAVKRMQAQL----CPYRVESQNDRFHIQWAHYHF-DLPLPT 244 Query: 253 V----PQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPH 308 + Q A A + A ++ ++ + A R + + PR++ DVAHN Sbjct: 245 LLRGEHQLCHCAAAAVILAHWFDLKPELMQRAVKEAHNFARLMVKNTRPRIVIDVAHNAD 304 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 +AE L + L R L V GML DKD L+S+ W+ L G RG A L Sbjct: 305 SAEILAHFLTTLDAPERFLFVCGMLRDKDHDAIFKQLQSLAQHWFLGGLTGARGTDAPTL 364 Query: 369 LEHLGNG-------KSFDSVAQAWDAAMADAKA---EDTVLVCGSFHTVAHVM 411 H + V QA+ AA A A +DT++V GSFHTV ++ Sbjct: 365 AMHALAAGIPENAITTCPDVIQAFRAAQQKAHAQDTQDTIVVMGSFHTVQQIL 417 >UniRef50_C8WXM1 FolC bifunctional protein n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXM1_ALIAD Length = 432 Score = 384 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 115/424 (27%), Positives = 176/424 (41%), Gaps = 25/424 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + Y+ L + GL+R+ + ++L + + VAGTNGKG+ C L ++L Sbjct: 3 YEEAVRYISTLRRFGMKPGLDRMRRILSKLDHPESDLCFYHVAGTNGKGSVCAMLAAMLT 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-DISLTYFEYGTLSA 131 A GY+ G+Y+SP L + RV + G + E + A T FE T A Sbjct: 63 ALGYRTGLYTSPGLGGFNGRVAIDGAPISEPEFAEHVEAVRRASDTSDPPTEFEVLTAVA 122 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 L F+ A ++ V+ E GLGGRLDATN+V V +T+++ DH + LGP I REKAGI Sbjct: 123 LLAFRSAGVERVVWETGLGGRLDATNVVWPHVTAITNVSYDHVEILGPTLVDIAREKAGI 182 Query: 192 FRSEKPAIVGEPE-MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH-GTLENLP 249 + P + + I A +G+ L G + +++T A+ G + P Sbjct: 183 VKPGVPVVTACADGAYRVIERTAARRGSRLVSVGRDVQFTITGAGVRLRGAYRGLFRDAP 242 Query: 250 ------LPLVPQPNAATALAALRASGLEVSENAIRDGIAS---AILPGRFQIVSESPR-V 299 NAA +LA L ++E +AS P R ++ R V Sbjct: 243 SVRLGLCGEHQAQNAAVSLAMLELGEGRIAEANWERALASLERVRWPLRCEVFDVGGRLV 302 Query: 300 IFDVAHNPHAAEYLTGRMKALPKN---GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 + D AHN A L ++ L K V DKD+ G LA + + D Sbjct: 303 VIDGAHNEEGARTLARALRRLGKGVGANGWRMVFAAFADKDVRGMLAQMLPLACDALMVR 362 Query: 357 LEGPRGATAEQLLEHLGNGKS------FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 PRGA L + S+ A A+ + ++V G+ + Sbjct: 363 SPHPRGADPRALAALACEIRPDLSIHVMSSIEDAVQEALDHPEP---IVVWGNLYMAELA 419 Query: 411 MEVI 414 I Sbjct: 420 RNTI 423 >UniRef50_B9KIR3 Folylpolyglutamate synthase (FolC) n=5 Tax=Rickettsiales RepID=B9KIR3_ANAMF Length = 455 Score = 384 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 127/418 (30%), Positives = 202/418 (48%), Gaps = 30/418 (7%) Query: 23 LHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESILMAAGYKVGVY 81 L + D L+R++ + RLG + P V VAGTNGKG+T L I +AG + VY Sbjct: 35 LECRVPDFQLDRITKMLERLGNPEKHMPPVVHVAGTNGKGSTIAFLAHIFRSAGIRAHVY 94 Query: 82 SSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLD 141 +SPHLV + ER+ + G+++ ++ AE E+A I T+FE T +A F + + D Sbjct: 95 TSPHLVEFNERIVLSGEQISDAYLDEILAECEAASSGIQTTFFEATTAAAFLAFSKVEAD 154 Query: 142 VVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG 201 + ++EVG+GGRLDATN+V+ ++++TSI+LDHT LG E I EK+GI + +V Sbjct: 155 ITLVEVGMGGRLDATNVVEPIMSIITSISLDHTSSLGTTVELIAGEKSGIIKRGTSCVVA 214 Query: 202 EPEMPST---IADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPN- 257 E S I A A L R G+EW+ + FS + E PLP +P + Sbjct: 215 PQETESIMRTIEYYAMRDQAFLYRGGIEWSCKKSSGRMLFSTGEASYE-FPLPSLPGDHQ 273 Query: 258 ---AATALAALRAS----GLEVSENAIRDGIASAILPGRFQIV---------SESPRVIF 301 A A+AA G ++ I G+ + P R + + + R+ Sbjct: 274 VINAGNAIAACSILSGKFGYKIDYEDIVGGLTNTRWPARLERITSGFIPKLLPKGWRLFL 333 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-P 360 D AHNP A+ L+ ++ G + ++GM KD L+ LK + ++ P Sbjct: 334 DGAHNPAGAQVLSDWIEQSTSGG-LYLIVGMTRGKDSKTFLSCLKKHIKFLCAVCVKSEP 392 Query: 361 RGATAEQLLEHLGN----GKSFDSVAQAWDAAMA--DAKAEDTVLVCGSFHTVAHVME 412 R AE+L + + + + ++ D+ E T+LVCGS +++ Sbjct: 393 RAQLAEELAQDAAELGIPSSAESDIQSSIRKILSIGDSGPEPTILVCGSLFLAGDLLK 450 >UniRef50_B0T696 FolC bifunctional protein n=2 Tax=Alphaproteobacteria RepID=B0T696_CAUSK Length = 437 Score = 384 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 131/422 (31%), Positives = 202/422 (47%), Gaps = 26/422 (6%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESILM 72 + L+ L+ LH K IDL L+R+ + LG + P V VAGTNGKG+T L ++ Sbjct: 9 DAALARLQALHPKLIDLSLDRMRRLCTALGEPQKRLPPVIHVAGTNGKGSTVAYLRAMAE 68 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AAG V V++SPHLVR+ ER+R+ G + ++ +E+A + +T+FE T +AL Sbjct: 69 AAGLTVHVFTSPHLVRFAERIRLAGTLITDAHLADVLERVEAANAGLPITFFEITTAAAL 128 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F + D+ ++EVGLGG LDATN+V V+V+ I +DH ++LG +I +EKAGI Sbjct: 129 QAFSEVPADLCLVEVGLGGVLDATNVVSPVVSVIAPIDIDHREFLGDTLAAIAQEKAGII 188 Query: 193 RSEKPAIVGEPEMPSTIADVAQE--KGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 + P + + + A L G +++ + + L +LP Sbjct: 189 KPNTPVVSARQAEEAERVVEREADLSEAPLTLMGRDFD-AWNERGRLLVQLQDRLLDLPA 247 Query: 251 PLVPQPN----AATALAA-LRASGLEVSENAIRDGIASAILPGRFQIVSESPR------- 298 P +P + A A+AA L + + E A+ GIA+ P RFQ ++ P Sbjct: 248 PSLPGEHQFANAGLAVAAILTLNDPRIDEAAMARGIAATTWPARFQRLTAGPLAERAKAA 307 Query: 299 ---VIFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 + D HNPHA + + L V + G+L +KD G A S+ + Sbjct: 308 DADLWLDGGHNPHAGLAVARALGDLAARDGRPVALIAGLLANKDATGFFAPFASLKARLF 367 Query: 354 CAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 EG A+A Q + DSV +A D A+A + VL+CGS + Sbjct: 368 SVTFEGHAAASAAQTAAAAELAGIRAHACDSVREALDKALAI-EPTPHVLICGSLYLAGE 426 Query: 410 VM 411 V+ Sbjct: 427 VL 428 >UniRef50_A6BCX0 Putative uncharacterized protein n=9 Tax=Clostridiales RepID=A6BCX0_9FIRM Length = 446 Score = 384 bits (987), Expect = e-105, Method: Composition-based stats. Identities = 117/441 (26%), Positives = 189/441 (42%), Gaps = 30/441 (6%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M+ K+ P+ + +Y+E + T LE RLG + VAGTNGK Sbjct: 2 MLTKKEPETFTY-EEAAAYIEEIPKFTKKHTLEHTKTFLKRLGNPAADRKIVHVAGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI- 119 G+ C L++ILMA G + G ++SPHLV ER+RV ++ F ++ + Sbjct: 61 GSVCAYLQAILMAEGKRTGFFTSPHLVSVNERIRVDNIQIDNETFLKVFRKVLKIVRQMV 120 Query: 120 -----SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDH 173 +YFE+ + F + ++ +ILE GLGGRLDATN +D +A++TSI+LDH Sbjct: 121 EDGIEHPSYFEFLFGMGMTAFAETDVEYIILETGLGGRLDATNAIDNPALAIITSISLDH 180 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSV 231 T LG E I EKAGI + P + I A E G + Sbjct: 181 TAILGDTIEKIAGEKAGIIKPGVPVFFDGSSKKAAEVIKAKASELGVSCREVTKNAYEIQ 240 Query: 232 TDHDWAFSDAHGTLEN----LPLPLVPQPNAATALAALRA-----SGLEVSENAIRDGIA 282 H + + + + +P+ A A AL A +G E+ + ++ +A Sbjct: 241 EVHRKYIAFSRRSAYDKDVIFQVPMCGCYQAMNAELALEASEYLLAGEEIHMDRWKEALA 300 Query: 283 SAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGR--VLAVIGMLHDKDIAG 340 GR + V + D AHNP A E +KAL ++ R ++ + + DK Sbjct: 301 ELHWEGRMERVGAH--ITVDGAHNPGAMEAFVESVKALDESERGEMVLLFSAVSDKKYDQ 358 Query: 341 TLAWLKSVVD--DWYCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADAK 393 + +L +D + +E RG AE+L + + + A AM + Sbjct: 359 MIEYLCENLDVKAYVVTQIEDERGVPAEELADVFRRYTDRPVYCKERLEDAVRTAMNERG 418 Query: 394 AEDTVLVCGSFHTVAHVMEVI 414 + GS + V + +++ Sbjct: 419 ETGEIYCLGSLYLVGMMKKLL 439 >UniRef50_Q1IVH6 FolC bifunctional protein n=2 Tax=Acidobacteria RepID=Q1IVH6_ACIBL Length = 447 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 119/420 (28%), Positives = 180/420 (42%), Gaps = 34/420 (8%) Query: 29 DLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVR 88 L + ++ L + +AGTNGKG+T TL SIL+AAGYK G+Y+SPHLV+ Sbjct: 24 KFDLAHMRVLLDALAHPERRFASVLIAGTNGKGSTAATLSSILLAAGYKTGLYTSPHLVK 83 Query: 89 YTERVRVQGQELPESAHTASFAEIESARGDI--------SLTYFEYGTLSALWLFKQAQL 140 ER R+ G ++ ++ TA++ +E+ + ++FE T A LF +A + Sbjct: 84 INERFRINGSQVNDAEFTAAYEHVETLASALVETKALPWHPSFFEMLTAMAFELFARAGI 143 Query: 141 DVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV 200 + +LEVG+GGRLDATN+V+ ++V+ I+LDH +LG I EKAGI + + Sbjct: 144 QIAVLEVGMGGRLDATNVVEPLISVIADISLDHQKFLGNTIAEIAAEKAGIIKPNGTVVT 203 Query: 201 GEPEMP-------STIADVAQEKGALLQRRG-----VEWNYSVTDHDWAFSDAHGTLE-N 247 + + A+ A+ ++ + + + +E N Sbjct: 204 LPQHPAANDVIGHAILDHQAKGISAVKHMPPMAPGSADYRDVEGRNRYPLEVMNEIIEVN 263 Query: 248 LPLPL-VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESP-----R 298 PLP N A A+ L G V+ I GI GRFQ++S Sbjct: 264 SPLPGRHQLRNLALAITTAEELARFGFPVTSKQIEQGIRETRWAGRFQVISAEKNALKRE 323 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 +IFDVAHNP A L + + V G +HDK + L + Sbjct: 324 LIFDVAHNPDGAWALRSALSDKIAERPLTLVFGAMHDKAFREMVQILFPTAQQVIVTQAK 383 Query: 359 GPRGATAEQLLEHLGNGKS----FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 PR AT +L E + SV A A ++V GS V M + Sbjct: 384 NPRAATTAELAEVAKEVGTEVVQCASVEAAVHKAPELTAENGVIVVTGSIFVVGEAMNAL 443 >UniRef50_B2IS30 Dihydrofolate synthetase, putative n=37 Tax=Bacteria RepID=B2IS30_STRPS Length = 418 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 110/415 (26%), Positives = 179/415 (43%), Gaps = 21/415 (5%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 +L + GL R+ LG + + + V GTNGKG+T + + M G K Sbjct: 8 EWLHSRIGLNFRSGLGRIQQAVDLLGNPEQSYPIIHVTGTNGKGSTIAFMRELFMGHGKK 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-----SLTYFEYGTLSAL 132 V ++SPH+V +R+ + GQ + ++ +++ + L++FE TL A Sbjct: 68 VATFTSPHIVSINDRICINGQPIADADFIRLADQVKEMEKTLLQTPDQLSFFELLTLVAF 127 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F++ ++D+V+LEVG+GG LD TN+V ++AV+TSI LDH + LG E+I +KAGIF Sbjct: 128 LYFREQEVDLVLLEVGIGGLLDTTNVVTGELAVITSIGLDHQETLGDSLEAIAEQKAGIF 187 Query: 193 RSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 ++ K A++ PE A+ L + G ++ D + + L Sbjct: 188 KAGKKAVIAKLPPEARLVCQKKAESLAVNLYQAGQDFLMLNGDFSSSLLNLSQLNIGLE- 246 Query: 251 PLVPQPNAATALAALRASGLE----VSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 + Q NAA AL E V E A+R + GR + + P++ D AHN Sbjct: 247 GVYQQENAALALQTFLLFMGEGKEAVDEQAVRKALEQTHWAGRLERIR--PQIYLDGAHN 304 Query: 307 PHAAEYLTGRMKALPKNG-RVLAVIGMLHDKDIAGTLAWLKSVVDDWYC--APLEGPRGA 363 A L +K + G R + G L KD G L +L + + Sbjct: 305 LPALTRLVEFIKEKEQEGYRPQILFGALKRKDYQGMLGYLTEKLPQVELKVTGFDYQGAL 364 Query: 364 TAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 + S + A A+D + V GS + ++ V + R Sbjct: 365 DERD----VTGYDIVSSYREFISDFEERADAQDLLFVTGSLYFISEVRGYLLDRE 415 >UniRef50_Q1JHI7 Folylpolyglutamate synthase / Dihydrofolate synthase n=20 Tax=Streptococcus RepID=Q1JHI7_STRPD Length = 430 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 101/416 (24%), Positives = 179/416 (43%), Gaps = 26/416 (6%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 +S++ + L R++ + LG + V GTNGKG+ L+ IL Sbjct: 12 YDSISWIHTFKANGRKTDLARMAWLLEALGRPQDKFPAIHVVGTNGKGSVTAYLQHILST 71 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTYFEY 126 +GY+VG ++SP ++ + +R+ + GQ + + + I +S T FE Sbjct: 72 SGYQVGTFTSPFIISFHDRICLNGQPISDLELAQCVSVIRPILTKMSLETNWDRPTEFEL 131 Query: 127 GTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 TL F +D+ I+E G+GG+ DATN+ A V SI+ DH + LG I Sbjct: 132 VTLIMFCYFANLKPVDIAIIEAGIGGKTDATNVFHALAVVCPSISFDHQERLGYSLAEIA 191 Query: 186 REKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 +KA + ++++P I+G+ E V Q+ G+ L + G ++ + ++ +F + Sbjct: 192 HQKAEVIKAKEPVIIGQLEQEASQVFQQVTQKAGSRLYQLGKDFLLNPSEKTISFQHDNL 251 Query: 244 TLENLPLPLVPQPNAATALAA------LRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 L L L L+ Q A A LR S ++S I+ GI + PGR + + P Sbjct: 252 NLTKLRLKLLGQHQKANACLTIMTAQLLRKSFPKISPKTIQKGIETTTWPGRSEFIQ--P 309 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 ++ D AHNP + L ++ + + L K +A LA L + + Sbjct: 310 NLLLDGAHNPDSIAKLKSLLQEEFPKRPIHILFAGLKRKPLADLLAQLDTF--EVSVTTF 367 Query: 358 EGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 + P E + K + Q +++ +V GS + ++ V + Sbjct: 368 DFPEANLLEDYPDKYPQVKDYRDWLQG------SVTSDELFVVTGSLYFISEVRQY 417 >UniRef50_B5IFG1 FolC bifunctional protein n=2 Tax=Aciduliprofundum boonei T469 RepID=B5IFG1_9EURY Length = 422 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 118/420 (28%), Positives = 182/420 (43%), Gaps = 28/420 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + Y+ NL + L L + A G + +AGTNGKG+ + SIL Y Sbjct: 6 IEYIYNLRRFGMKLDLSIMREFAEIRGNPQDKFKSVHIAGTNGKGSVASAIYSILRK-NY 64 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-----ARGDISLTYFEYGTLSA 131 VG+Y+SPHLVRY+ER+ V +E+ E E++ A+ + + T+FE T+ A Sbjct: 65 NVGIYTSPHLVRYSERIIVNDREISEDYIARFVREVKPIIEELAKENRNPTFFEVSTMLA 124 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 F +D +LEVGLGGRLDATNIV ++ + +I LDHT LG I REKAGI Sbjct: 125 FEYFSYMSVDFAVLEVGLGGRLDATNIVMPEITSIVTIDLDHTHILGDTIRDIAREKAGI 184 Query: 192 FRSEKPAIVGE--PEMPSTIADVAQEKGALLQ-----RRGVEWNYSVTDHDWAFSDAHGT 244 + P ++GE E I +A+ + A + + + + T Sbjct: 185 IKPNVPVVIGENKKEAIEEIKRIAELRNAPYHNIWDEMEFEDVHIDLNGLRFKAHTPIST 244 Query: 245 LENLPLPLVPQPNAATALAALR-----ASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 + PL + L A+R +S + I DGI + RFQ+ P + Sbjct: 245 Y-TIETPLPGKHQITNMLVAIRIAELLQENYSISHSDIEDGIKNIKWKDRFQVKRRRPLL 303 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 IFD AHNP AA L ++ + + +L DK+I L + V ++ Sbjct: 304 IFDSAHNPSAARALVSTIRDV-GIEEPTFLFSILSDKNIDEFLKEISKVSKKIIVTEIDY 362 Query: 360 PRGAT-----AEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 R T E ++ + A AM E ++ GS + + + + + Sbjct: 363 ERRRTELEDIVEHAKKYFSEVIPIKNPCDALKYAME---NEKKIIATGSIYLLGELEKCL 419 >UniRef50_C7GYL0 Tetrahydrofolate synthase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7GYL0_9FIRM Length = 441 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 123/433 (28%), Positives = 193/433 (44%), Gaps = 31/433 (7%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + + + +++L LGL+R++ + A LGV + VAGTNGKG+ C L+ IL Sbjct: 1 MGNAVDKIKSLGRFGSKLGLDRMNRLMAELGVSCADFKIIHVAGTNGKGSVCTMLDKILR 60 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR-------GDISLTYFE 125 A G K G+Y+SP+L Y + + V G+ + + A G++++T FE Sbjct: 61 AHGIKTGMYTSPYLSNYRDSIAVDGRSISCEDLDRVGETVLEAADKLPKEDGELAVTEFE 120 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T AL+ FK+ + VILE GLGG LD+TNI A VAV+TSI+ DH D LG I Sbjct: 121 VITGLALYYFKEVGAEYVILETGLGGALDSTNIAPAKVAVITSISYDHMDVLGDSLAEIA 180 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF----- 238 + KAGI + A+V E E S I + +K A + R + D++ F Sbjct: 181 KNKAGIIKEGATAVVNVDEEEALSVIKNEVCKKHANIVRADEAVKINSVDYNKKFSLVDM 240 Query: 239 SDAHGTLENLPLPLVPQPNAA---TALAAL----RASGLEVSENAIRDGIASAILPGRFQ 291 S A + L+ + + T +A + A G + + GRF+ Sbjct: 241 STASQNYGRIKFSLLGKHQLSNLKTVIATVGELKSAFGFCERHEITVEALGDVHFSGRFE 300 Query: 292 IVSES---PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 + ++ D AHN E L +K N ++LAV ML DK + L L Sbjct: 301 VFEGDAGCADIVLDGAHNVAGIEALEQNVKLYYPNAKILAVTSMLGDKQVDEILHRLCKF 360 Query: 349 VDDWYCAPLEGPRGATAEQLLEHL-------GNGKSFDSVAQAWDAAMADAKAEDTVLVC 401 +D + R +A ++LE GN + +A+ A + D +L Sbjct: 361 SNDVIFTEINNERRISAHEMLEIAKQSEGNTGNYQEIPDTGKAFTQAYDSRRNYDLILFT 420 Query: 402 GSFHTVAHVMEVI 414 GS + + + + Sbjct: 421 GSLYMMGDIRRRL 433 >UniRef50_C0FMZ7 Putative uncharacterized protein n=1 Tax=Roseburia inulinivorans DSM 16841 RepID=C0FMZ7_9FIRM Length = 452 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 118/443 (26%), Positives = 193/443 (43%), Gaps = 47/443 (10%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 +Y N+ LGL+ + + LG ++ + +AGTNGKG+T LE +L+ AGY+ Sbjct: 8 AYAVNVSRSGSILGLDSIENLMHELGDIQERLKIIHIAGTNGKGSTGAYLERVLIEAGYR 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEYGTLSA 131 VG YSSP + E R+ Q + + +++ A +G T FE T A Sbjct: 68 VGRYSSPAVFDPMEVWRINLQSMSHEEYADIMEQVKCACDRMVEKGMEHPTIFEVETAMA 127 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESIGREKAG 190 F Q + D V+LEVG+GGR DATN++ V +V+TS+++DH +LG I + KAG Sbjct: 128 FLYFYQKKCDYVLLEVGMGGRTDATNLIKKPVCSVITSVSMDHMQFLGNTLTEIAQAKAG 187 Query: 191 IFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH---GTL 245 I + + P + + E I A+++ A L V T+ H GT+ Sbjct: 188 IIKKDCPVVTILQKAEAMEAIEAEAEKQHARLYTADVSKVTVETETLKEIRFDHPGLGTV 247 Query: 246 ENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 N A+ L+ L +++ I DGI + + PGRF+I+ E P I D AH Sbjct: 248 TTQLTGTYQVENCCLAVTVLKEV-LGIADRIIIDGIRNTVWPGRFEIIGEQPLFIIDGAH 306 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT- 364 N AA L+ ++ N + +IG+L DK+ L + + + PR Sbjct: 307 NEDAALQLSASVEKYFTNIPITYIIGVLADKEHKKVLEAMLPYAGAVFTVTPDNPRAMRA 366 Query: 365 ---------------------AEQL------------LEHLGNGKSFDSVAQAWDAAMAD 391 E++ +E L + S+ +A A+ Sbjct: 367 EELASEAEAIVARLWKKRAGKPEKVQGTENSPQGAGGMEPLPKVSACSSMKEAVQLALEH 426 Query: 392 AKAEDTVLVCGSFHTVAHVMEVI 414 K + +L GS + + +++ Sbjct: 427 TKKDGVILAFGSLSYLKEIRQIM 449 >UniRef50_D2LRU4 FolC bifunctional protein n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2LRU4_BACS4 Length = 426 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 104/421 (24%), Positives = 183/421 (43%), Gaps = 19/421 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + + + Y+ + I L+R+ + L + VAGTNGKG+T L S+ Sbjct: 3 TTYKNAIDYVNSKRVAGIRYDLKRMEKLMEALNHPERKVKTIHVAGTNGKGSTVTFLRSM 62 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE------SARGDISLTYF 124 L AG+ VG Y +P E++ + G+ + ES T +EI D ++ F Sbjct: 63 LQEAGFFVGTYMTPSFGDVREQIAINGEPMSESQFTTMISEIAPTVAVVEQEMDELISEF 122 Query: 125 EYGTLSALWLFK-QAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 E T AL+ F ++ +D+ ++E G+GGR DATN++ V+V+T++ DH ++LG + Sbjct: 123 ELITALALYYFSFKSPVDIAVIEAGMGGRNDATNVIFPLVSVITNVGYDHQEYLGDSLKE 182 Query: 184 IGREKAGIFRSEKPAIVG-EPEMPSTIADVAQEKGALLQ----RRGVEWNYSVTDHDWAF 238 I +EKAGI + + + + + A+EK + L R E + ++ Sbjct: 183 IAKEKAGIIKPGVAVMTACDSNIQFVFEEEAKEKRSSLYALQSRITYETSLEADTQTLSY 242 Query: 239 SDAHGTLENLPLPLVPQPNAATALAAL-------RASGLEVSENAIRDGIASAILPGRFQ 291 A+ L+++PL L+ A AL + L V++ G++ A L GRF+ Sbjct: 243 EAAYRKLKHVPLKLLGDHQGKNAALALMTIDYLHQFYALMVTDEQAVAGLSKAQLAGRFE 302 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 I+ P ++ D AHNP A E +K + + + + DK+I + L+ Sbjct: 303 IIDTIPVIVLDTAHNPPAIEKTLETVKKRFREKEITVLFAAMKDKEIKTMIEQLEGATSK 362 Query: 352 WYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 + PR + + +AW + VL+ GS + + Sbjct: 363 LFVTTFSSPRALPLSDFEQFGIHENQLVEHPKAWMKDYVINNESNIVLITGSHQFINDMK 422 Query: 412 E 412 Sbjct: 423 R 423 >UniRef50_C8P2J5 Folylpolyglutamate synthase (Tetrahydrofolate synthase) (Fragment) n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P2J5_ERYRH Length = 394 Score = 382 bits (982), Expect = e-104, Method: Composition-based stats. Identities = 113/395 (28%), Positives = 177/395 (44%), Gaps = 26/395 (6%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 G++ A +G + + + GTNGKG+T +IL AGY VG ++SPHL + Sbjct: 9 GIDLFRQCLADMGNPQDSLTCIHIGGTNGKGSTTNYTRAILQEAGYSVGTFTSPHLTVHN 68 Query: 91 ERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLG 150 +R+R+ + + +S E L+ FE L ++ F +D I EVGLG Sbjct: 69 DRIRINNENISDSDLLMYINVTEPFWDQYQLSMFEIDVLISILYFIDNDIDYAIYEVGLG 128 Query: 151 GRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEP-----EM 205 GRLDATN++ + +T+I LDH + LG E I EKAGI + P E E+ Sbjct: 129 GRLDATNVIQPVITGITNIGLDHMNILGDTIEKIATEKAGIIKMNVPFFTTERKDSCLEV 188 Query: 206 PSTIADVAQEKGALL-----QRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAAT 260 S D+ Q + +R G+ + + V + + + L NA+ Sbjct: 189 FSYFTDLKQTNMHQVMIPEPKREGLAYYFDVLEEPYVIQNQ---------GLYQVGNASL 239 Query: 261 ALAALRASG-LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKA 319 A+ ++A + V I++ IASA GRF+ V + V D AHN E L M+ Sbjct: 240 AIHLVKALPHITVDTKTIQNAIASASWAGRFEPVLDG--VYVDGAHNEMGIEMLVRSMEM 297 Query: 320 LPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFD 379 LP +AV L DKD + L+SV D+ + R AE+L N + Sbjct: 298 LP--RPWVAVFTALKDKDYTLMINKLESVFDEVIITQFDFYRSERAEKLA-FGHNVTIIE 354 Query: 380 SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 +A D M + T ++ GS + ++ + + Sbjct: 355 DQYKAIDTGMKH-RNNGTCVITGSLYFISEARDYL 388 >UniRef50_C2BRT3 Possible tetrahydrofolate synthase n=3 Tax=Mobiluncus RepID=C2BRT3_9ACTO Length = 549 Score = 381 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 117/437 (26%), Positives = 198/437 (45%), Gaps = 37/437 (8%) Query: 16 WLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 + + L I+ LE V V LG + + GTNGK + R +E++L G Sbjct: 114 YETLLTRRAEHQIEPSLEPVRGVLDYLGNPQELFHSVHITGTNGKTSIARMIEALLAELG 173 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-------ARGDISLTYFEYGT 128 Y+ G ++SPHLV ER+ + L ++ +IE+ A L++FE T Sbjct: 174 YRTGRFTSPHLVDVCERISIDQAPLTTEQFVQAYEDIEAQLALWEHAHPGRRLSFFEVMT 233 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 + A LF +DV ++EVG+GGR DATN++DAD AV+ I+L+H WLG +I REK Sbjct: 234 VMAYALFADVPIDVAVVEVGMGGRWDATNVIDADTAVIGPISLEHEQWLGKGLTNIAREK 293 Query: 189 AGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNY-----SVTDHDWAFSDA 241 AGI R ++ A+V + E + I D A + +L+ G ++ +V Sbjct: 294 AGIMRPQRVAVVAKQPDEALAVIRDTAAAEDVVLRYEGEDFEVLRRVPAVGGQVLDIRTP 353 Query: 242 HGTLENLPLPL---VPQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQIVSES 296 +++ LPL NAA AL A+ A G+ + ++ + + PGR +++ + Sbjct: 354 AAVYQDIYLPLYGEFQAENAALALTAVEAQLGGMPLHGESVERALGTVKSPGRLEVLHST 413 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P ++ D HNP AA+ L ++ + + + + DKDI L ++ + + Sbjct: 414 PMIVADAGHNPGAAQALRRAIEDDFRFEHTVGIYSAMADKDIETVLGIMEPTIAELIVTQ 473 Query: 357 LEGPRGATAEQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDT---------VLVC 401 + G R A E L + + S+ +A A + +D V++ Sbjct: 474 MPGERAAKVEDLQTLAADVFGDERVYAIGSLPEAIAKA---GEIDDLQGGVPGSTGVVIF 530 Query: 402 GSFHTVAHVMEVIDARR 418 GS +V+ + Sbjct: 531 GSVVLAGMAQDVLRKDK 547 >UniRef50_UPI0001C34EE0 FolC bifunctional protein n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001C34EE0 Length = 456 Score = 381 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 120/441 (27%), Positives = 189/441 (42%), Gaps = 30/441 (6%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 +P A +L + + L+ + + +G+ + VAGTNGKG+ C Sbjct: 22 SPDACREAEQYLDGIPKFSRE--KHSLDDIRAMMKAMGLSLDKIRLIHVAGTNGKGSVCA 79 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDI 119 L SIL AG V++SPHLV ER G++ E +F + + G Sbjct: 80 FLSSILREAGEHTAVFTSPHLVSVRERFCFDGEQAGEKEFLQAFYRVREGLCRLQSLGLT 139 Query: 120 SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLG 178 TYFE+ L + + + ++E GLGGRLDATN VD + V+TSI+LDH ++LG Sbjct: 140 HPTYFEFLFLMFAAMMQSRKGFTAVVETGLGGRLDATNAVDRPTLCVLTSISLDHMEYLG 199 Query: 179 PDRESIGREKAGIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVE-WNYSVTDHD 235 E I EKAGI + P + +P + I D A+E + + G + ++ SV Sbjct: 200 NTVELIAGEKAGIIKPGVPVVYDSTDPAAAAVIRDRARELKSPARAVGTDSFSESVLKDG 259 Query: 236 WAFSDAHGTLENLPLPLVPQPNAATALAALRASGLE-VSENAIRDGIASAILPGRFQIVS 294 F +G E L +P Q A A+ A++A+ + + E A+R+G+ + PGR + + Sbjct: 260 HLFIRKNGE-EPLEIPFAAQYQAVNAMLAVQAAEILGIPERAVREGLQKTVWPGRMEEIM 318 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV--DDW 352 P V D AHN +L R + + + DK+ L D Sbjct: 319 --PGVYLDGAHNEGGIRAFARAAASL-SGKRKILLFAVSSDKEYREMAEILLREFAPDVL 375 Query: 353 YCAPLEGPRGATAEQLLEHLGNGKS-----------FDSVAQAWDAAMADAKAEDTVLVC 401 + RG +L E + S +A A+ + EDTV Sbjct: 376 ILTQIAYGRGLDIHRLEEASREAMAKAGGHGPRLFVRPSAEEALLTALDEKGEEDTVFCA 435 Query: 402 GSFHTVAHVMEVIDARRSGGK 422 GS + + + +VI G + Sbjct: 436 GSLYLIGEMKDVIRRNHYGER 456 >UniRef50_C7RHW8 FolC bifunctional protein n=3 Tax=Anaerococcus RepID=C7RHW8_ANAPD Length = 425 Score = 381 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 94/418 (22%), Positives = 183/418 (43%), Gaps = 20/418 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + ++ N S + LE++ + + V +AGTNGKG+T + + L Sbjct: 4 FNQYYEFILNRGSTSGGHSLEKIKNLLEYFDNPQDKIKVIHIAGTNGKGSTANMIANTLS 63 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-----ARGDISLTYFEYG 127 +VG+++SP++ + E + + G ++ +S ++ + + +YFE Sbjct: 64 REN-RVGLFTSPYMTKINEAISISGVDISDSDFAEIIDRLKKPLEELDKKGLHNSYFEVL 122 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGR 186 T F + ++DV ++EVGLGG LD+TNI+ V+T+I+ DH LG E I + Sbjct: 123 TAIMYIYFYEKKVDVAVVEVGLGGSLDSTNIIKSPLACVITTISKDHIQILGDSLEEIAQ 182 Query: 187 EKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 KAGI + + + E + + + L E + + + Sbjct: 183 NKAGIIKDKSEVFLYPKEGTVKEVFIKKIENTSSRLHTFDKEEINIIKTGPDYNEFSFRS 242 Query: 245 LENLPLPLVPQPNAATALAALRASG-----LEVSENAIRDGIASAILPGRFQIVSESPRV 299 +N+ LV A+ AL + E I +G+ + PGR ++++++PRV Sbjct: 243 YKNIKTRLVGIHQIYNAVTALITLDFLKDEFSICERDIYEGLLTTRNPGRLELINKNPRV 302 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-E 358 + D +HN A + L + + K +++ +L DKD + L + D+ + + Sbjct: 303 LVDGSHNREAIDALIDSISSY-KYRKLIVGFSILKDKDYDYVIDSLAKIADEIIVTKIKD 361 Query: 359 GPRGATAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 PR ++L + + +A++ + A +D VL CGS + V +++ Sbjct: 362 NPRAFDTDELYSLVKDKAKKAIEIVDLVKAYEYSKELAHEDDLVLWCGSLYLVGDILK 419 >UniRef50_A3ZWP1 Folyl-polyglutamate synthetase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZWP1_9PLAN Length = 470 Score = 381 bits (979), Expect = e-104, Method: Composition-based stats. Identities = 136/446 (30%), Positives = 198/446 (44%), Gaps = 33/446 (7%) Query: 3 IKRTPQAASPLASWLSYLEN--LHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 I+ +A L ++Y + ++ L R+ + LG L + +AGT GK Sbjct: 19 IRSYDEAIDFLLGRINYERAAVIPYRSPQFHLARMRRLDQLLGNLVDQLKIVHIAGTKGK 78 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFA-------EIE 113 G+T TL +IL A GY+VG++SSPHL R ER + T +I+ Sbjct: 79 GSTATTLSAILEADGYQVGLFSSPHLERLEERFAINRIACSADEVTQLIHDIAPVVLQID 138 Query: 114 SARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDH 173 + R TYFE T AL F + +D ILEVGLGGRLD+TNI V+V+T+I+ DH Sbjct: 139 AERDGDGPTYFEITTAMALMHFVRKGVDAAILEVGLGGRLDSTNICRPLVSVITTISRDH 198 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY-- 229 LG I EKAG+ ++E P I G +P+ + I +A + A L G ++ Sbjct: 199 MALLGDTLAEIAAEKAGVIKTETPIISGVDQPDPTAVIEQIAAQHAAQLIEVGRDFVVQS 258 Query: 230 ---SVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAA------LRASGLEVSENAIRDG 280 D W + TL L + + A A L++ G VSE AIR G Sbjct: 259 HGERTFDLTWRQGEKSETLTGLMCRMAGKHQMRNAALAVMVAKSLQSYGFTVSEAAIRRG 318 Query: 281 IASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAG 340 ++ A LPGR + +++SP + D AHN + L + LP N R V+ + DK+ Sbjct: 319 VSDAELPGRIERLADSPVIYVDAAHNDASITALLDVLNELPVNRR-RLVLALSSDKEHRE 377 Query: 341 TLAWLKSVVDDWYCAP-LEGPRGATA---EQLLEHLGNGKS------FDSVAQAWDAAMA 390 L L D+ + PR E L L G+ + QA+ AA+A Sbjct: 378 ILKLLLPHFDEIWFTRYATNPRAVEPAELEALAVKLPTGRRTVIRHIVEDPQQAFAAAIA 437 Query: 391 DAKAEDTVLVCGSFHTVAHVMEVIDA 416 + D + V GSF Sbjct: 438 ASDENDLLCVAGSFFIAGEFRRFFRE 463 >UniRef50_D1VUP4 Tetrahydrofolate synthase n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VUP4_9FIRM Length = 422 Score = 380 bits (977), Expect = e-104, Method: Composition-based stats. Identities = 93/426 (21%), Positives = 187/426 (43%), Gaps = 27/426 (6%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 +++ +L + +D +E V+ + +L + ++GTNGKG+ LE+ L Sbjct: 2 TYIKWLIERKTPMVDFTVENVAFLLEKLNNPQDRIKTIHISGTNGKGSLVFYLENALFFN 61 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-----LTYFEYGTL 129 YKVG ++SP++ + + + GQ++ + A+I ++ +T FE Sbjct: 62 NYKVGTFTSPYMTDINDSIEINGQKISNEDYENVLAKIYPIILEMDKINKYVTGFEIQVA 121 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREK 188 +A F + ++DV I+EVG+GGR DATN++ ++ TSI+LDH + LG + I K Sbjct: 122 AAFLYFYEKKVDVAIIEVGMGGRFDATNVMKSPLLSAFTSISLDHANLLGKTLKEIAWNK 181 Query: 189 AGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVE----WNYSVTDHDWAFSDAH 242 GI + +P + + E+ + ++A E + + + N + ++++F Sbjct: 182 GGIIKKSRPTFLYPQKEEVYKELKEIADENKSEIYKFDFSEINIINEDINGNEFSFR--- 238 Query: 243 GTLENLPLPLVPQPNAATALAALR-----ASGLEVSENAIRDGIASAILPGRFQIVSESP 297 +N+ L+ + A A AL + + + IR GI P R +I+S+ P Sbjct: 239 -EYKNIKTSLIGRHQAYNASLALSILSYLKNFFVLDDEKIRQGIYKTTNPARLEIISDEP 297 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 ++ D +HN + L + +++ +L DK+ + L D + Sbjct: 298 LILMDGSHNEESINSLISNLDK-FNYEKLILGFSILRDKEREKIIKNLAKYADTVVLTDI 356 Query: 358 EGPRGATAEQLLEHLGNGKS-----FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 + R + L + + +A + + A +D +L CGS + + + Sbjct: 357 DSDRKSDINDLYNIFKSYTDKKIYMETDIEKAVNKTLELASKKDLILWCGSLYLMKDIRH 416 Query: 413 VIDARR 418 + + Sbjct: 417 FLKNHK 422 >UniRef50_B6YQL7 Folylpolyglutamate synthase n=7 Tax=Bacteroidales RepID=B6YQL7_AZOPC Length = 432 Score = 380 bits (977), Expect = e-104, Method: Composition-based stats. Identities = 113/426 (26%), Positives = 200/426 (46%), Gaps = 21/426 (4%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 Q + + + + G+E L+ L +AGTNGKG+T Sbjct: 2 DYEQTVEYIYNTSPMFQQIGGNAYKKGMENSFLIDKYLNHPHTKYKTIHIAGTNGKGSTS 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L S+L + YKVG+Y+SPHL+ + ER+++ G + ++ A+ + I ++F Sbjct: 62 HLLASVLQESNYKVGLYTSPHLLDFRERIKINGSSINKNFVINFIAKYKFFFESIQPSFF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T A F + +DV ++EVGLGG+LD TN++ ++++T+I+ DHT+ LG I Sbjct: 122 ELTTAMAFSYFAEQAIDVAVIEVGLGGKLDCTNLITPVLSIITNISFDHTNLLGNTLTQI 181 Query: 185 GREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVT-----DHDWA 237 +EKAGI + P I+G+ E + D+ ++ E N+ ++ W Sbjct: 182 AKEKAGIIKPNIPVIIGKAEEKVKKVFLDLKRKAQNTKFIFAQEENFILSSKLLLSGYWQ 241 Query: 238 FSD-AHGTLENLPLPLVPQPNAATALAALRASG---LEVSENAIRDGI----ASAILPGR 289 + + L N NA T L A++ L + A+ G A+ + GR Sbjct: 242 LNTKEYPNLINELGGYAQIQNAVTTLCAIKILKRDVLNIPPQAVYRGFRYVTANTGIKGR 301 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 +QI+ +P+++ D+ HN EY+ ++++ K ++ + G++ DKDI L L Sbjct: 302 WQILQYAPKILLDIGHNIGGLEYVVQQLES-EKYDKLHIIFGIVSDKDILSILQILPKNA 360 Query: 350 DDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 +Y PR A+ L+ + G+++ +V A+ +A A ED + + GS Sbjct: 361 -IYYFTQANIPRALNAQTLMNYAKSFGLRGRNYSTVTHAFASAKLSATKEDVIFIGGSTF 419 Query: 406 TVAHVM 411 VA + Sbjct: 420 VVADAL 425 >UniRef50_A4BRV9 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Nitrococcus mobilis Nb-231 RepID=A4BRV9_9GAMM Length = 426 Score = 379 bits (975), Expect = e-103, Method: Composition-based stats. Identities = 177/417 (42%), Positives = 238/417 (57%), Gaps = 12/417 (2%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 S L WL + E LH +TI+LGLERV+ VA RLGV + V TV GTNGKG+T LE+ Sbjct: 3 CSSLRDWLRWQEGLHPRTIELGLERVAAVAKRLGVDRSGARVITVGGTNGKGSTVAYLEA 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 +L A GY GVYSSPH+ RY ER+R+ G+E + A A+F ++ AR D LTYFE+GTL Sbjct: 63 MLRALGYHPGVYSSPHVQRYNERIRIDGREATDEAIVAAFEAVDEARSDTPLTYFEFGTL 122 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +AL LF+ Q DV +LEVG+GGRLDA NI+ ADVAV+T++ LDHTDWLG DR+SIGREKA Sbjct: 123 AALHLFQLTQCDVWLLEVGMGGRLDAVNILAADVAVLTNVELDHTDWLGHDRDSIGREKA 182 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNY--SVTDHDWAFSDAHGTLEN 247 GI R +P I G MP T+ A+ G+ +R G +++Y V W + L Sbjct: 183 GIMRPGRPVIFGSVAMPCTVTAHARCLGSDARRLGRDFDYGSPVGVPHWWWRGRSVHLSE 242 Query: 248 LPLPLVPQPNAATALAALRASGLEVSE------NAIRDGIASAILPGRFQIVSESPRVIF 301 LPLP + + AA A+ E +A R + LPGR Q ++ P + Sbjct: 243 LPLPGLSGCHQLANAAAALAALEAFGEPAARLADAARRALPRVYLPGRAQWLAGPPDWLL 302 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGP 360 DVAHN AA L ++A +GRV + G+L KD+AG +A L +VD WY L +G Sbjct: 303 DVAHNAAAAARLPALLRARSGSGRVRCIFGLLRRKDLAGVVAPLLPLVDQWYLLQLADGE 362 Query: 361 RGATAEQLLEHLGNGKSFDSVAQA---WDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 A A N ++ A +A+ D ++ GSF VA ++ + Sbjct: 363 ALAAAHVAAHLRANEARIAAIGPAHELVSRVCGEAETVDCIVAFGSFRVVAEILHEL 419 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B5FFN4 Bifunctional protein FolC n=7 Tax=Vibrionaceae R... 502 e-141 UniRef50_B0K4K8 FolC bifunctional protein n=15 Tax=Clostridia Re... 498 e-139 UniRef50_C5CEI6 FolC bifunctional protein n=1 Tax=Kosmotoga olea... 496 e-139 UniRef50_A0LIV6 FolC bifunctional protein n=1 Tax=Syntrophobacte... 491 e-137 UniRef50_A4XL37 FolC bifunctional protein n=5 Tax=Clostridia Rep... 483 e-135 UniRef50_B8FMP6 FolC bifunctional protein n=1 Tax=Desulfatibacil... 481 e-134 UniRef50_B9MJT0 FolC bifunctional protein n=2 Tax=Clostridiales ... 478 e-133 UniRef50_C7N4J3 Folylpolyglutamate synthase/dihydrofolate syntha... 478 e-133 UniRef50_Q05865 Folylpolyglutamate synthase n=5 Tax=Bacillus sub... 475 e-132 UniRef50_B8DZV7 FolC bifunctional protein n=1 Tax=Dictyoglomus t... 474 e-132 UniRef50_B5YD69 Folylpolyglutamate synthase n=1 Tax=Dictyoglomus... 473 e-132 UniRef50_C0GEY6 FolC bifunctional protein n=1 Tax=Dethiobacter a... 473 e-132 UniRef50_C7H9L3 Tetrahydrofolate synthase n=2 Tax=Faecalibacteri... 472 e-132 UniRef50_B8FVG3 FolC bifunctional protein n=2 Tax=Desulfitobacte... 472 e-131 UniRef50_Q1JY09 FolC bifunctional protein n=1 Tax=Desulfuromonas... 469 e-130 UniRef50_C0QB10 FolC n=1 Tax=Desulfobacterium autotrophicum HRM2... 468 e-130 UniRef50_Q3AF86 Folylpolyglutamate synthase n=1 Tax=Carboxydothe... 468 e-130 UniRef50_Q604P6 Folylpolyglutamate synthase/dihydrofolate syntha... 467 e-130 UniRef50_P43775 Folylpolyglutamate synthase n=258 Tax=Gammaprote... 466 e-130 UniRef50_B8DHJ7 Folylpolyglutamate synthase (Folylpoly-gamma-glu... 466 e-130 UniRef50_A5I6P2 FolC bifunctional protein n=14 Tax=Clostridia Re... 465 e-129 UniRef50_B8I1X5 FolC bifunctional protein n=2 Tax=Clostridium Re... 465 e-129 UniRef50_C0ZAJ3 Folylpolyglutamate synthase n=1 Tax=Brevibacillu... 465 e-129 UniRef50_B5EAK4 FolC bifunctional protein n=6 Tax=Geobacter RepI... 464 e-129 UniRef50_Q71ZB7 FolC bifunctional protein n=12 Tax=Listeria RepI... 464 e-129 UniRef50_A8ZTL3 FolC bifunctional protein n=1 Tax=Desulfococcus ... 464 e-129 UniRef50_A0AJ00 FolC protein n=2 Tax=Listeria RepID=A0AJ00_LISW6 462 e-129 UniRef50_A6TN35 FolC bifunctional protein n=2 Tax=Alkaliphilus R... 462 e-129 UniRef50_A8SN77 Putative uncharacterized protein n=1 Tax=Parvimo... 462 e-128 UniRef50_B9XQF6 FolC bifunctional protein n=1 Tax=bacterium Elli... 462 e-128 UniRef50_D2RP25 FolC bifunctional protein n=2 Tax=Acidaminococcu... 462 e-128 UniRef50_A8FFU4 Tetrahydrofolate synthase n=88 Tax=Bacillaceae R... 461 e-128 UniRef50_A8UBK8 Folyl-polyglutamate synthetase n=1 Tax=Carnobact... 461 e-128 UniRef50_C7MLS9 Folylpolyglutamate synthase/dihydrofolate syntha... 460 e-128 UniRef50_A6C8Q2 Folyl-polyglutamate synthetase n=1 Tax=Planctomy... 460 e-128 UniRef50_D0WG21 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 459 e-128 UniRef50_Q1PZI3 Similar to multifunctional folylpolyglutamate sy... 457 e-127 UniRef50_C8QY00 FolC bifunctional protein n=1 Tax=Desulfurivibri... 457 e-127 UniRef50_B6J6W5 Folylpolyglutamate synthase n=6 Tax=Coxiella bur... 457 e-127 UniRef50_Q9K8G9 Folyl-polyglutamate synthetase n=1 Tax=Bacillus ... 456 e-127 UniRef50_Q02Z16 Folylpolyglutamate synthase n=20 Tax=Bacteria Re... 456 e-127 UniRef50_Q5CB75 Folylpolyglutamate synthase/dihydrofolate syntha... 456 e-127 UniRef50_Q5WEQ5 Folylpolyglutamate synthase n=1 Tax=Bacillus cla... 455 e-126 UniRef50_Q12P54 FolC bifunctional protein n=10 Tax=Shewanella Re... 455 e-126 UniRef50_C9KNY5 Tetrahydrofolate synthase n=2 Tax=Veillonellacea... 455 e-126 UniRef50_A7VV81 Putative uncharacterized protein n=1 Tax=Clostri... 454 e-126 UniRef50_C9LMI1 Tetrahydrofolate synthase n=1 Tax=Dialister invi... 454 e-126 UniRef50_Q2BMN3 Folylpolyglutamate synthase n=1 Tax=Neptuniibact... 453 e-126 UniRef50_B0VF02 FolC bifunctional protein n=1 Tax=Candidatus Clo... 452 e-125 UniRef50_C6MBR5 FolC bifunctional protein n=1 Tax=Nitrosomonas s... 452 e-125 UniRef50_Q2LQC5 Folylpolyglutamate synthase / dihydrofolate synt... 452 e-125 UniRef50_C2E893 Folylpolyglutamate synthase / dihydrofolate synt... 452 e-125 UniRef50_C6P114 FolC bifunctional protein n=1 Tax=Sideroxydans l... 451 e-125 UniRef50_D1BNH4 FolC bifunctional protein n=3 Tax=Veillonella Re... 450 e-125 UniRef50_A5N275 FolC n=22 Tax=Clostridium RepID=A5N275_CLOK5 450 e-125 UniRef50_B5YJI6 Folylpolyglutamate synthase n=1 Tax=Thermodesulf... 450 e-125 UniRef50_Q3A6L0 Folylpolyglutamate synthetase; dihydrofolate syn... 450 e-125 UniRef50_Q38XD0 Putative polylpolyglutamate synthase n=1 Tax=Lac... 449 e-125 UniRef50_A5IBI5 FolC bifunctional protein n=4 Tax=Legionella pne... 449 e-124 UniRef50_C9RB31 FolC bifunctional protein n=1 Tax=Ammonifex dege... 448 e-124 UniRef50_Q15VG0 FolC bifunctional protein n=1 Tax=Pseudoalteromo... 447 e-124 UniRef50_A9KNK7 FolC bifunctional protein n=1 Tax=Clostridium ph... 446 e-124 UniRef50_C6D869 FolC bifunctional protein n=3 Tax=Bacillales Rep... 446 e-124 UniRef50_Q01UR3 FolC bifunctional protein n=1 Tax=Candidatus Sol... 446 e-124 UniRef50_C2ETR7 Tetrahydrofolate synthase n=3 Tax=Lactobacillus ... 445 e-123 UniRef50_A6VWY8 FolC bifunctional protein n=2 Tax=Marinomonas Re... 445 e-123 UniRef50_Q3JCB5 Folylpolyglutamate synthetase n=3 Tax=Gammaprote... 445 e-123 UniRef50_A5ZW55 Putative uncharacterized protein n=1 Tax=Ruminoc... 445 e-123 UniRef50_A2SKX9 Cytoplasmic peptidoglycan synthetase, C-terminal... 444 e-123 UniRef50_Q1WT76 Folylpolyglutamate synthase / Dihydrofolate synt... 444 e-123 UniRef50_A8PMD7 FolC bifunctional protein n=1 Tax=Rickettsiella ... 444 e-123 UniRef50_B2J1B6 FolC bifunctional protein n=25 Tax=Bacteria RepI... 444 e-123 UniRef50_Q88LD8 Folylpolyglutamate synthetase n=23 Tax=Pseudomon... 444 e-123 UniRef50_A1UZ44 FolC bifunctional protein n=107 Tax=cellular org... 444 e-123 UniRef50_Q03EP1 Folylpolyglutamate synthase n=2 Tax=Pediococcus ... 444 e-123 UniRef50_A8MIR1 FolC bifunctional protein n=1 Tax=Alkaliphilus o... 443 e-123 UniRef50_Q5QWH7 Folylpolyglutamate synthase n=2 Tax=Idiomarina R... 443 e-123 UniRef50_C6J218 Bifunctional protein folC n=1 Tax=Paenibacillus ... 443 e-123 UniRef50_C5CFS4 FolC bifunctional protein n=1 Tax=Kosmotoga olea... 443 e-123 UniRef50_C1D9J6 FolC n=26 Tax=Neisseriaceae RepID=C1D9J6_LARHH 443 e-123 UniRef50_C6N083 FolC bifunctional protein n=2 Tax=Legionella Rep... 442 e-122 UniRef50_C1I5V8 FolC bifunctional protein n=1 Tax=Clostridium sp... 442 e-122 UniRef50_B2V618 FolC bifunctional protein n=3 Tax=Sulfurihydroge... 441 e-122 UniRef50_Q0A999 FolC bifunctional protein n=1 Tax=Alkalilimnicol... 440 e-122 UniRef50_A7C245 Folylpolyglutamate synthase/dihydrofolate syntha... 440 e-122 UniRef50_B0S2B5 Folylpolyglutamate synthase n=2 Tax=Finegoldia m... 440 e-122 UniRef50_C6AMR7 FolC bifunctional protein n=3 Tax=Pasteurellacea... 440 e-122 UniRef50_C0CPE6 Putative uncharacterized protein n=2 Tax=Clostri... 440 e-122 UniRef50_B9L391 Folylpolyglutamate synthase (Folylpoly-gamma-glu... 439 e-122 UniRef50_C9L620 Tetrahydrofolate synthase n=1 Tax=Blautia hansen... 439 e-122 UniRef50_A1HP48 FolC bifunctional protein n=1 Tax=Thermosinus ca... 439 e-121 UniRef50_Q0AGX2 FolC bifunctional protein n=1 Tax=Nitrosomonas e... 439 e-121 UniRef50_Q6AJ73 Related to folylpolyglutamate synthase n=3 Tax=D... 438 e-121 UniRef50_C8ZWR3 FolC family protein n=26 Tax=Enterococcus RepID=... 438 e-121 UniRef50_A6GNX1 FolC bifunctional protein n=1 Tax=Limnobacter sp... 437 e-121 UniRef50_UPI0001C42143 folyl-polyglutamate synthetase n=1 Tax=Ba... 437 e-121 UniRef50_Q3IF42 Bifunctional: folylpolyglutamate synthase; dihyd... 437 e-121 UniRef50_Q2JLQ4 Folylpolyglutamate synthase n=2 Tax=Synechococcu... 437 e-121 UniRef50_Q492H5 Folylpolyglutamate synthase n=3 Tax=Enterobacter... 437 e-121 UniRef50_Q1D8V1 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 437 e-121 UniRef50_A1SW71 FolC bifunctional protein n=2 Tax=Psychromonas R... 436 e-121 UniRef50_B4CZE0 FolC bifunctional protein n=1 Tax=Chthoniobacter... 436 e-121 UniRef50_B2A1F3 FolC bifunctional protein n=1 Tax=Natranaerobius... 435 e-120 UniRef50_B2GB02 Folylpolyglutamate synthase n=11 Tax=Lactobacill... 435 e-120 UniRef50_C0QUQ6 Folylpolyglutamate synthetase n=2 Tax=Aquificale... 435 e-120 UniRef50_B0MBL9 Putative uncharacterized protein n=2 Tax=Clostri... 435 e-120 UniRef50_B0UU80 FolC bifunctional protein n=14 Tax=Pasteurellace... 435 e-120 UniRef50_A9QPJ9 Folylpolyglutamate synthase n=1 Tax=Methylacidip... 435 e-120 UniRef50_C2BDR7 Possible tetrahydrofolate synthase n=2 Tax=Anaer... 435 e-120 UniRef50_D1PK55 Tetrahydrofolate synthase n=1 Tax=Subdoligranulu... 435 e-120 UniRef50_Q6FEE4 Bifunctional protein n=18 Tax=Acinetobacter RepI... 435 e-120 UniRef50_Q67SJ1 Folylpolyglutamate synthase n=1 Tax=Symbiobacter... 434 e-120 UniRef50_B5JSE1 FolC bifunctional protein n=1 Tax=gamma proteoba... 434 e-120 UniRef50_C5SCQ4 FolC bifunctional protein n=1 Tax=Allochromatium... 433 e-120 UniRef50_UPI0001745D4D FolC bifunctional protein n=1 Tax=Verruco... 433 e-120 UniRef50_B3QVA8 FolC bifunctional protein n=1 Tax=Chloroherpeton... 433 e-120 UniRef50_C0CJ78 Putative uncharacterized protein n=2 Tax=Clostri... 432 e-120 UniRef50_C6VI65 Folylpolyglutamate synthase n=8 Tax=Bacilli RepI... 432 e-119 UniRef50_C6Y3V5 FolC bifunctional protein n=4 Tax=Sphingobacteri... 432 e-119 UniRef50_Q0AWF7 Putative uncharacterized protein n=1 Tax=Syntrop... 432 e-119 UniRef50_D2R4J4 FolC bifunctional protein n=1 Tax=Pirellula stal... 432 e-119 UniRef50_Q12D50 FolC bifunctional protein n=4 Tax=Proteobacteria... 431 e-119 UniRef50_B8CY17 Folylpolyglutamate synthase n=1 Tax=Halothermoth... 431 e-119 UniRef50_D0MEF9 FolC bifunctional protein n=1 Tax=Rhodothermus m... 430 e-119 UniRef50_UPI0000E88026 folylpolyglutamate synthetase n=1 Tax=Met... 430 e-119 UniRef50_Q28WD6 FolC bifunctional protein n=2 Tax=Rhodobacterale... 429 e-119 UniRef50_B7RU63 FolC bifunctional protein n=1 Tax=marine gamma p... 429 e-119 UniRef50_D2QCN6 FolC bifunctional protein n=1 Tax=Spirosoma ling... 429 e-118 UniRef50_D1PA28 Tetrahydrofolate synthase n=1 Tax=Prevotella cop... 429 e-118 UniRef50_B3ELQ9 FolC bifunctional protein n=2 Tax=Chlorobiaceae ... 428 e-118 UniRef50_A8F8Q4 FolC bifunctional protein n=1 Tax=Thermotoga let... 428 e-118 UniRef50_C0EHC4 Putative uncharacterized protein n=1 Tax=Clostri... 428 e-118 UniRef50_A8RF48 Putative uncharacterized protein n=1 Tax=Eubacte... 427 e-118 UniRef50_C6LLF0 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 426 e-118 UniRef50_A6LA17 Folylpolyglutamate synthase n=8 Tax=Bacteroidale... 425 e-117 UniRef50_D1CGA1 FolC bifunctional protein n=1 Tax=Thermobaculum ... 425 e-117 UniRef50_C0EVS7 Putative uncharacterized protein n=1 Tax=Eubacte... 425 e-117 UniRef50_B1CAR2 Putative uncharacterized protein n=1 Tax=Anaerof... 424 e-117 UniRef50_C6W460 FolC bifunctional protein n=7 Tax=Bacteroidetes ... 424 e-117 UniRef50_C6WVE3 FolC bifunctional protein n=1 Tax=Methylotenera ... 424 e-117 UniRef50_Q1N6P7 Folylpolyglutamate synthetase n=1 Tax=Bermanella... 424 e-117 UniRef50_UPI0000E0E8A2 FolC bifunctional protein n=1 Tax=Rhodoba... 424 e-117 UniRef50_B8KYD9 Folylpolyglutamate synthase n=1 Tax=gamma proteo... 423 e-117 UniRef50_B0MYL2 Putative uncharacterized protein n=1 Tax=Alistip... 423 e-117 UniRef50_C2KWA8 Possible tetrahydrofolate synthase n=1 Tax=Oriba... 423 e-117 UniRef50_A6FEP3 Dihydrofolate synthase / folylpolyglutamate synt... 423 e-117 UniRef50_Q31HH1 FolC bifunctional folylpolyglutamate synthase/di... 422 e-116 UniRef50_C3J886 Folylpolyglutamate synthase n=15 Tax=Bacteria Re... 422 e-116 UniRef50_UPI0001BC3950 FolC bifunctional protein n=1 Tax=Butyriv... 422 e-116 UniRef50_UPI00016C3FCF FolC bifunctional protein n=1 Tax=Gemmata... 422 e-116 UniRef50_C6LLD0 Tetrahydrofolate synthase n=3 Tax=Clostridiales ... 422 e-116 UniRef50_B6JCP5 FolC bifunctional protein n=17 Tax=Alphaproteoba... 422 e-116 UniRef50_Q1GD59 FolC bifunctional protein n=6 Tax=Alphaproteobac... 422 e-116 UniRef50_A0YB05 FolC bifunctional protein n=1 Tax=marine gamma p... 420 e-116 UniRef50_Q3B220 Folylpolyglutamate synthetase n=8 Tax=Chlorobiac... 419 e-116 UniRef50_A5FMS8 FolC bifunctional protein n=21 Tax=Bacteroidetes... 419 e-116 UniRef50_B4VMJ0 FolC bifunctional protein n=2 Tax=Cyanobacteria ... 419 e-115 UniRef50_Q7NLP7 Folylpolyglutamate synthase n=1 Tax=Gloeobacter ... 419 e-115 UniRef50_UPI0001C16345 Folylpolyglutamate synthetase n=2 Tax=Nos... 419 e-115 UniRef50_Q1IVH6 FolC bifunctional protein n=2 Tax=Acidobacteria ... 418 e-115 UniRef50_D1AJ52 FolC bifunctional protein n=1 Tax=Sebaldella ter... 417 e-115 UniRef50_Q2SJC8 Folylpolyglutamate synthase n=1 Tax=Hahella chej... 417 e-115 UniRef50_C4LJV2 Dihydrofolate synthase / folylpolyglutamate synt... 417 e-115 UniRef50_D2RA71 Bifunctional protein FolC n=3 Tax=Bifidobacteria... 417 e-115 UniRef50_Q11UV3 Tetrahydrofolylpolyglutamate synthase (Folylpoly... 417 e-115 UniRef50_Q8D2P3 FolC protein n=1 Tax=Wigglesworthia glossinidia ... 416 e-115 UniRef50_A3CKF3 Dihydrofolate synthetase, putative n=32 Tax=Stre... 416 e-115 UniRef50_UPI0001C36E14 FolC bifunctional protein n=1 Tax=Ruminoc... 415 e-114 UniRef50_Q47XK6 FolC bifunctional protein n=1 Tax=Colwellia psyc... 415 e-114 UniRef50_Q1QDK0 FolC bifunctional protein n=4 Tax=Moraxellaceae ... 415 e-114 UniRef50_C4Z2M8 Folylpolyglutamate synthase n=1 Tax=Eubacterium ... 415 e-114 UniRef50_B1HVC8 Folylpolyglutamate synthase n=2 Tax=Bacillaceae ... 415 e-114 UniRef50_A8RV28 Putative uncharacterized protein n=1 Tax=Clostri... 415 e-114 UniRef50_C8WXM1 FolC bifunctional protein n=2 Tax=Alicyclobacill... 414 e-114 UniRef50_B0TC04 Folylpolyglutamate synthase n=5 Tax=Clostridia R... 414 e-114 UniRef50_D1AAV2 FolC bifunctional protein n=1 Tax=Thermomonospor... 414 e-114 UniRef50_B3DQR8 Folylpolyglutamate synthase n=18 Tax=Bifidobacte... 414 e-114 UniRef50_B4RUR1 Bifunctional folylpolyglutamate synthase/dihydro... 414 e-114 UniRef50_A9BIJ6 FolC bifunctional protein n=1 Tax=Petrotoga mobi... 413 e-114 UniRef50_A5KJF0 Putative uncharacterized protein n=4 Tax=Clostri... 413 e-114 UniRef50_A5TUM3 Tetrahydrofolate synthase n=15 Tax=Fusobacterium... 412 e-114 UniRef50_D0WR93 Tetrahydrofolate synthase n=2 Tax=Actinomycetale... 412 e-113 UniRef50_Q13EP9 FolC bifunctional protein n=37 Tax=Alphaproteoba... 412 e-113 UniRef50_A7NFK2 FolC bifunctional protein n=2 Tax=Roseiflexus Re... 412 e-113 UniRef50_B1VGM7 Dihydrofolate synthase / folylpolyglutamate synt... 412 e-113 UniRef50_A6BCX0 Putative uncharacterized protein n=9 Tax=Clostri... 412 e-113 UniRef50_C9M7C2 Tetrahydrofolylpolyglutamate synthase/dihydrofol... 411 e-113 UniRef50_A6DMK1 Folylpolyglutamate synthase n=1 Tax=Lentisphaera... 411 e-113 UniRef50_A8RZ26 Putative uncharacterized protein n=1 Tax=Clostri... 410 e-113 UniRef50_Q8K9X3 Dihydrofolate synthase n=1 Tax=Buchnera aphidico... 410 e-113 UniRef50_B1YJU6 FolC bifunctional protein n=2 Tax=Exiguobacteriu... 410 e-113 UniRef50_C7JGW9 Bifunctional protein FolC n=8 Tax=Acetobacter pa... 410 e-113 UniRef50_B4RCL3 Bifunctional dihydrofolate synthase/folylpolyglu... 410 e-113 UniRef50_D1N952 FolC bifunctional protein n=1 Tax=Victivallis va... 409 e-113 UniRef50_A1U0X0 FolC bifunctional protein n=3 Tax=Marinobacter R... 409 e-112 UniRef50_A8YUM7 Folylpolyglutamate synthase n=28 Tax=Lactobacill... 408 e-112 UniRef50_A0LA36 FolC bifunctional protein n=2 Tax=cellular organ... 408 e-112 UniRef50_B5IFG1 FolC bifunctional protein n=2 Tax=Aciduliprofund... 408 e-112 UniRef50_Q49Y95 Folylpolyglutamate synthase n=66 Tax=Staphylococ... 408 e-112 UniRef50_A4A847 Folylpolyglutamate synthase/dihydrofolate syntha... 407 e-112 UniRef50_Q89AT2 Dihydrofolate synthase n=4 Tax=Buchnera aphidico... 407 e-112 UniRef50_B7ARH5 Putative uncharacterized protein n=1 Tax=Bactero... 407 e-112 UniRef50_Q1QY39 FolC bifunctional protein n=1 Tax=Chromohalobact... 407 e-112 UniRef50_Q1JHI7 Folylpolyglutamate synthase / Dihydrofolate synt... 407 e-112 UniRef50_C4V4R4 Possible tetrahydrofolate synthase n=2 Tax=Selen... 407 e-112 UniRef50_P15925 Folylpolyglutamate synthase n=9 Tax=Lactobacillu... 407 e-112 UniRef50_C2BRT3 Possible tetrahydrofolate synthase n=3 Tax=Mobil... 406 e-112 UniRef50_Q3ZAH8 Folylpolyglutamate synthetase n=5 Tax=Dehalococc... 406 e-112 UniRef50_Q31PP5 FolC bifunctional protein n=2 Tax=Synechococcus ... 406 e-112 UniRef50_D2LRU4 FolC bifunctional protein n=1 Tax=Bacillus cellu... 406 e-112 UniRef50_A8SU33 Putative uncharacterized protein n=2 Tax=Clostri... 406 e-111 UniRef50_B3E778 FolC bifunctional protein n=3 Tax=Desulfuromonad... 405 e-111 UniRef50_Q97AP2 Folylpolyglutamate synthase n=2 Tax=Thermoplasma... 405 e-111 UniRef50_C7RCA3 FolC bifunctional protein n=1 Tax=Kangiella kore... 405 e-111 UniRef50_B5ZCR5 FolC bifunctional protein n=2 Tax=Gluconacetobac... 404 e-111 UniRef50_B1H0E2 Folylpolyglutamate synthetase n=1 Tax=uncultured... 404 e-111 UniRef50_UPI0001C34EE0 FolC bifunctional protein n=1 Tax=Clostri... 404 e-111 UniRef50_A1ZCQ8 Folylpolyglutamate synthase n=1 Tax=Microscilla ... 404 e-111 UniRef50_C1CYP7 Putative tetrahydrofolate synthase (Folylpolyglu... 404 e-111 UniRef50_B3PFP2 Folylpolyglutamate synthetase n=1 Tax=Cellvibrio... 404 e-111 UniRef50_B1ZVD5 FolC bifunctional protein n=4 Tax=Verrucomicrobi... 403 e-111 UniRef50_A5Z386 Putative uncharacterized protein n=1 Tax=Eubacte... 403 e-111 UniRef50_Q6KZL1 Folylpolyglutamate synthase/dihydrofolate syntha... 402 e-110 UniRef50_C7RHW8 FolC bifunctional protein n=3 Tax=Anaerococcus R... 402 e-110 UniRef50_D0KZW9 FolC bifunctional protein n=1 Tax=Halothiobacill... 402 e-110 UniRef50_D1BZM6 FolC bifunctional protein n=10 Tax=Actinomycetal... 402 e-110 UniRef50_C0D144 Putative uncharacterized protein n=1 Tax=Clostri... 402 e-110 UniRef50_A3ZWP1 Folyl-polyglutamate synthetase n=1 Tax=Blastopir... 402 e-110 UniRef50_B9ZQU2 FolC bifunctional protein n=1 Tax=Thioalkalivibr... 400 e-110 UniRef50_B2IS30 Dihydrofolate synthetase, putative n=37 Tax=Bact... 400 e-110 UniRef50_Q0BQJ2 Folylpolyglutamate synthase n=2 Tax=Acetobactera... 400 e-110 UniRef50_D0BMT5 Bifunctional protein FolC n=1 Tax=Granulicatella... 400 e-110 UniRef50_B0P9P5 Putative uncharacterized protein n=1 Tax=Anaerot... 399 e-110 UniRef50_A8SYS4 Putative uncharacterized protein n=2 Tax=Clostri... 399 e-109 UniRef50_B0T696 FolC bifunctional protein n=2 Tax=Alphaproteobac... 399 e-109 UniRef50_A7HJX6 FolC bifunctional protein n=3 Tax=Thermotogaceae... 399 e-109 UniRef50_C0W165 Possible tetrahydrofolate synthase n=1 Tax=Actin... 399 e-109 UniRef50_Q1JBW2 Folylpolyglutamate synthase / Dihydrofolate synt... 398 e-109 UniRef50_B5Y836 Folylpolyglutamate synthase/dihydrofolate syntha... 398 e-109 UniRef50_A9WDT0 FolC bifunctional protein n=4 Tax=Chloroflexi (c... 398 e-109 UniRef50_D1VUP4 Tetrahydrofolate synthase n=1 Tax=Peptoniphilus ... 398 e-109 UniRef50_B1I4S5 FolC bifunctional protein n=1 Tax=Candidatus Des... 397 e-109 UniRef50_B8GQE7 FolC bifunctional protein n=1 Tax=Thioalkalivibr... 397 e-109 UniRef50_Q2GGC6 Folylpolyglutamate synthase n=11 Tax=Rickettsial... 397 e-109 UniRef50_A6WDS1 FolC bifunctional protein n=2 Tax=Actinomycetale... 397 e-109 UniRef50_C7GYL0 Tetrahydrofolate synthase n=1 Tax=Eubacterium sa... 396 e-109 UniRef50_Q6MAP9 Putative folylpolyglutamate synthase n=1 Tax=Can... 396 e-109 UniRef50_C8NGA7 FolC bifunctional protein n=1 Tax=Granulicatella... 395 e-108 UniRef50_Q8EPN5 Folyl-polyglutamate synthase n=1 Tax=Oceanobacil... 395 e-108 UniRef50_A1AXP8 FolC bifunctional protein n=5 Tax=Bacteria RepID... 395 e-108 Sequences not found previously or not previously below threshold: >UniRef50_B5FFN4 Bifunctional protein FolC n=7 Tax=Vibrionaceae RepID=B5FFN4_VIBFM Length = 426 Score = 502 bits (1294), Expect = e-141, Method: Composition-based stats. Identities = 220/425 (51%), Positives = 287/425 (67%), Gaps = 8/425 (1%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M +P+A S L+ WL YLE++H+ IDLGL+RV VA R + KPAP V TVAGTNGK Sbjct: 1 MTTFDSPKATSDLSMWLRYLESIHTSAIDLGLDRVQRVAQRAKLTKPAPTVITVAGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 G+TC +ESIL+ AGY+VGVYSSPHL+RY ER+R+ G +L +S + SFA IE+ R DIS Sbjct: 61 GSTCALMESILINAGYRVGVYSSPHLIRYNERIRINGNDLSDSLISQSFAAIEAWRKDIS 120 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 L+ FE+GTLSALW FK Q+DVV+LEVGLGGRLDATN+VD DV+++TS+A+DH DWLG D Sbjct: 121 LSLFEFGTLSALWAFKAHQVDVVLLEVGLGGRLDATNVVDHDVSIITSLAVDHVDWLGDD 180 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV--TDHDWAF 238 E IG EKAGIFRSEK AI G+P PS++A A + A L + G +++Y+V W++ Sbjct: 181 IEVIGFEKAGIFRSEKAAICGQPNPPSSVAAHADDINADLYQVGYQFDYNVHADTQTWSW 240 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES-- 296 L+NLPLP +P NAATA+ AL SGLE+S+ I +G+ SA LPGR Q ++ Sbjct: 241 KSGAFDLDNLPLPNLPLANAATAIMALGVSGLELSDINIVEGLKSARLPGRMQRLTRGNS 300 Query: 297 ---PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 P +I DVAHNPH+A YL +++ N ++ AV+GMLHDKDI TL V+D WY Sbjct: 301 EFEPTIILDVAHNPHSAHYLVQQVRQRFPNKKIHAVVGMLHDKDIKSTLGEFTGVIDVWY 360 Query: 354 CAPLEGPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A L GPR A A +L L + S A+ A+ A+++D +LV GSFHTV V + Sbjct: 361 PASLSGPRAANASELTAVLSKEITEYSSPVDAFKVALQQAESDDLILVFGSFHTVGEVWD 420 Query: 413 VIDAR 417 Sbjct: 421 YWKKE 425 >UniRef50_B0K4K8 FolC bifunctional protein n=15 Tax=Clostridia RepID=B0K4K8_THEPX Length = 429 Score = 498 bits (1283), Expect = e-139, Method: Composition-based stats. Identities = 128/422 (30%), Positives = 204/422 (48%), Gaps = 20/422 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + Y+ ++ I LGLE + + +G + + + VAGTNGKG+T + +IL Sbjct: 3 YEEAIGYIHGIYKFGIKLGLENIRKLLDYMGNPQKSLKIIHVAGTNGKGSTSAFISNILQ 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 AGYKV +Y+SP+L + ER+R+ G+ + + I+ + T FE Sbjct: 63 QAGYKVALYTSPYLEEFEERMRINGENISKEKLIYYVEYIKPIISRMVEEGYNHPTEFEV 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIG 185 T A F ++D V+LEVGLGGR DATN +D + V+V+T+I DHTD LG I Sbjct: 123 VTAIAFKYFYDEKVDFVVLEVGLGGRFDATNAIDSSLVSVITTIDYDHTDRLGHTLGEIA 182 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS-DAH 242 EKAGI + + + +PE I + + + A L N + + + F + Sbjct: 183 YEKAGIIKQKGVVVSFYQQPEAMKVIIEACEVRNAYLTVLEKS-NVIIKEQNPDFQIFDY 241 Query: 243 GTLENLP---LPLVPQPNAATALAALRAS---GLEVSENAIRDGIASAILPGRFQIVSES 296 ++L L NAA A+ ++ G E++E IR+G+ A PGR +++ + Sbjct: 242 KKYKDLKITLLGEHQIYNAALAIESVEKLKMYGYEITEKDIREGLYRAKWPGRLEVMRKK 301 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P V+ D AHNP L +K L K +++ VIGML DKD L + + Sbjct: 302 PYVVIDGAHNPQGMTVLKESLK-LFKYDKLILVIGMLKDKDTQKMLDIIVPEANMIITTT 360 Query: 357 LEGPRGATAEQLLEHL--GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 R A +L E + + +++ +A A+ AK ED VL CGS + + +V ++ Sbjct: 361 PISERAYKASELAERIEKEKVIAIENIEEAVKYALDIAKEEDMVLFCGSLYMIGYVRSML 420 Query: 415 DA 416 Sbjct: 421 KK 422 >UniRef50_C5CEI6 FolC bifunctional protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CEI6_KOSOT Length = 428 Score = 496 bits (1279), Expect = e-139, Method: Composition-based stats. Identities = 136/427 (31%), Positives = 210/427 (49%), Gaps = 23/427 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L YL +L I G+ R+ ++ LG + + V VAGTNGKG+T + SI Sbjct: 1 MDYKEALDYLYSLRRFGIKPGVRRIKMLLELLGNPQDSLNVVHVAGTNGKGSTVAFISSI 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYF 124 L AGY+VG Y SPHL+ +TER+ + G ++ E +I ++ S T+F Sbjct: 61 LKEAGYRVGTYISPHLIDFTERMTINGLQIKEEVVVEILNKIRPHITEVANSKFGSPTFF 120 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T A FKQ ++D +LEVGLGG DATN+V V+V+T+ DH D LG D SI Sbjct: 121 EVVTAMAFVYFKQQKVDFAVLEVGLGGENDATNVVKPLVSVITNSDYDHMDILGNDITSI 180 Query: 185 GREKAGIFRSEKPAIV-GEPEMPSTIADVAQEKGALLQRRGVEWNYS-----VTDHDWAF 238 +E AGI + + E E I + +EK A + + G + Y + + Sbjct: 181 AKEDAGIIKENGFVVTAAEGEALDVIKKIGEEKRARIYQIGRDIKYEFVNSDLKWQRFNV 240 Query: 239 SDAHGTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQI 292 +NL +PL+ + A+ LR +E+S+ +IR G+ + PGRF+I Sbjct: 241 KGIFSESDNLKIPLLGKYQLINASCAVGAIEILRFYDIEISDESIRKGLENTFWPGRFEI 300 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKA-LPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 V ++P V+ D AHN AA+ L + L K +++ VIG++ DK++ + L + Sbjct: 301 VQDAPMVVLDGAHNHLAAKRLKEALMEVLEKKDKLILVIGIMKDKEVEKIVKELAPLAYK 360 Query: 352 WYCAPLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 + PR T+ L E + N + V A + A+++AK D V V GS +TV Sbjct: 361 VVATSPKTPRATTSHDLREIVVKFNKNISVVEDVETALELALSEAKENDIVCVTGSLYTV 420 Query: 408 AHVMEVI 414 + + Sbjct: 421 GEARKFL 427 >UniRef50_A0LIV6 FolC bifunctional protein n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LIV6_SYNFM Length = 431 Score = 491 bits (1266), Expect = e-137, Method: Composition-based stats. Identities = 128/425 (30%), Positives = 199/425 (46%), Gaps = 15/425 (3%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 + S + YL L I GL + + RLG + +AGTNGKG+T Sbjct: 3 EMSLSEYQDSVDYLFGLQKHGIKFGLNSTNNLLMRLGNPHRSLRCIHIAGTNGKGSTAAM 62 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD-ISLTYFE 125 L S+L G +VG+Y+SPHLVR+TER R+ +E+ A F ++ D T+FE Sbjct: 63 LSSMLRKHGVRVGLYTSPHLVRFTERFRIDEREVRIDRILAIFEKVRKQIDDREPPTFFE 122 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T AL LF + ++ ++E G+GGRLDATN++ V+V+T++ DH ++LG SI Sbjct: 123 VVTAMALLLFAEENVEWAVIETGMGGRLDATNVIHPRVSVITNVTFDHQEYLGSTLSSIA 182 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT-DHDWAFSDAH 242 REKAGI + E P + G +P + + Q K A+L R G E+ + Sbjct: 183 REKAGIIKEEVPVVTGVTQPLVHGVLTATCQRKRAVLYRLGKEFKARRRPGGAARYQGLK 242 Query: 243 GTLENLPLPL---VPQPNAATALAALRAS----GLEVSENAIRDGIASAILPGRFQIVSE 295 +L + L NAA A+A L + A+ G+++ P R +++ Sbjct: 243 WDWPSLEISLPGVHQVRNAALAIAVLEVLEEKGDFYIDSGAVELGLSAVRWPARLEVLGR 302 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 P ++ D AHNP AE L ++ ++ V+G++ DKDIAG L + + Sbjct: 303 RPLIVLDGAHNPQGAESLRDALRNCFTYQKLHLVMGIMEDKDIAGIFRRLLPLAETAIFT 362 Query: 356 PLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 R A A++L + N VA+A A A +D + + GS + V Sbjct: 363 QPRYSRAAKADRLRQLARPYAGNHCVIPDVAEAIQQAGRFAGPDDLICITGSLYFAGEVK 422 Query: 412 EVIDA 416 E+ Sbjct: 423 ELFGE 427 >UniRef50_A4XL37 FolC bifunctional protein n=5 Tax=Clostridia RepID=A4XL37_CALS8 Length = 431 Score = 483 bits (1244), Expect = e-135, Method: Composition-based stats. Identities = 123/427 (28%), Positives = 197/427 (46%), Gaps = 21/427 (4%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + L Y+ + + LGLE + + +G + + VAGTNGKG+TC + Sbjct: 2 SMTYEEALEYIHGTYKFGVKLGLENIKKLLELMGNPQKDLRIVHVAGTNGKGSTCAFINQ 61 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR------GDISLTY 123 +L+ AGYKVG+Y+SP+L + ER+++ + ++ G T Sbjct: 62 MLIEAGYKVGLYTSPYLEFFNERIKINNIPISNDELATITEFVKDKVDLMISQGFNHPTE 121 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRE 182 FE T A FK+ +D V+LEVGLGGR DATN+V+ ++ ++TSI DH D LG E Sbjct: 122 FEIVTAIAFEYFKRTNVDFVVLEVGLGGRFDATNVVETPELCIITSIGYDHMDILGQTIE 181 Query: 183 SIGREKAGIFRSEKPAIVGEP---EMPSTIADVAQEKGALLQRRGVEWNY---SVTDHDW 236 I EKAGI + I+G E I+ V ++K A L ++ ++ + Sbjct: 182 QIAYEKAGIIKESSTVILGLQRYKEAIDVISKVCKQKNANLIEVKSDYKIIKNTLDGIVF 241 Query: 237 AFSDAHGTLENLPLPLVPQPNAATALAALRAS-----GLEVSENAIRDGIASAILPGRFQ 291 + G +NL + L+ AL + A +S A+ G+ +A GRF+ Sbjct: 242 DCTTPKGIYKNLEINLLGVHQVENALNCIYAFEYLSDKYNISTIALVKGLLNAKWNGRFE 301 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 I+S+ P VI D AHN L K K+ ++ AV+G+L DK+ L+ +K V D Sbjct: 302 IISKEPLVILDGAHNIDGMRVLVDSCKQYLKDKKISAVVGILKDKEYKKMLSMIKEVTSD 361 Query: 352 WYCAPLEGP-RGATAEQLLEHLGN--GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 + R + + E + +A D ++ A+ + +L+CGS + V Sbjct: 362 VIFTLVPYQKRAFSPAEAKEAALKFGFEFIKDYKEAIDVSLKKAEKDTAILICGSLYLVG 421 Query: 409 HVMEVID 415 I Sbjct: 422 AARTYIK 428 >UniRef50_B8FMP6 FolC bifunctional protein n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FMP6_DESAA Length = 444 Score = 481 bits (1239), Expect = e-134, Method: Composition-based stats. Identities = 128/423 (30%), Positives = 202/423 (47%), Gaps = 14/423 (3%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + + L +L I LGLE + + +G +AGTNGKG+ + Sbjct: 2 TDINAFNQAMEELFSLGRFGIKLGLETILAMLKGIGDPHLRIQCIHIAGTNGKGSVAQNT 61 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-DISLTYFEY 126 SIL AAGYKVGVY+SPHLV ER V G+ + + ++ ++S G + T+FEY Sbjct: 62 ASILQAAGYKVGVYTSPHLVHINERFTVNGRPISDDEVLEAYQAVKSVSGLERHATFFEY 121 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T AL+ F +A +D ++E G+GGRLDATN++ ++ ++T+I+++H +LG I Sbjct: 122 TTAMALYAFDRAGVDYAVMETGMGGRLDATNVLKPELCIITNISVEHEMYLGNTIAQIAY 181 Query: 187 EKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY-SVTDHDWAFSDAHG 243 EKAGI + P + G +P+ + A E A L R G ++ + + F Sbjct: 182 EKAGIIKPGVPVVTGVRQPDAIKAVEKAAAESKAPLYRMGKDFKTRRLQGGGFNFYGQDH 241 Query: 244 TLENLPLPL---VPQPNAATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 + L L PNA+ ALA AL G +++E + G+ PGR + + ESP Sbjct: 242 AWKGLQCRLKGEYQIPNASLALAGCQALTKRGAKITEEQAKAGLEQVKWPGRLETIQESP 301 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 VI D AHN A + LT + + V + G L DK L L+++ Sbjct: 302 MVILDGAHNLAAMKVLTKYLAETFADRDVTVITGFLDDKPYKKMLPMLEALAAKIIITRP 361 Query: 358 EGPRGATAEQLLEHLGNGK----SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 + R ++L + N K SV +A A+ +A+ D ++V GS + V + Sbjct: 362 KIGRAVETKELTPLIRNKKDRFVEKPSVEEAVKYALENARDTDVIVVAGSLYIVGEARQT 421 Query: 414 IDA 416 + Sbjct: 422 LQD 424 >UniRef50_B9MJT0 FolC bifunctional protein n=2 Tax=Clostridiales RepID=B9MJT0_ANATD Length = 432 Score = 478 bits (1231), Expect = e-133, Method: Composition-based stats. Identities = 113/426 (26%), Positives = 197/426 (46%), Gaps = 21/426 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L ++ + + LGLE ++ + +G + V VAGTNGKG+TC + + Sbjct: 1 MTYEQALDFIHSTYKFGTKLGLENITKLLEFMGNPQKGLKVIHVAGTNGKGSTCAFINQM 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYF 124 L+ AG++VG+Y+SP L + ER+++ Q + + ++ ++ T F Sbjct: 61 LIEAGFRVGLYTSPFLESFNERIKLNNQPIDNQELASITEFVKERIEELIRQGFSHPTEF 120 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRES 183 E T FK+ +D V+LEVGLGGR DATN+V+ ++ V+TSI DH D LG E Sbjct: 121 EVVTAIGFEFFKRKNVDFVVLEVGLGGRFDATNVVENPEICVITSIGFDHMDILGSTIEK 180 Query: 184 IGREKAGIFRSEKPAIVGEP---EMPSTIADVAQEKGALLQRRGVEWNY---SVTDHDWA 237 I EKAGI + I+ E+ I+ V +E+ A L ++ ++ + Sbjct: 181 IAFEKAGIIKQNTKVILALQRYEEVKEVISKVCKEQNAQLIEVERNYHVLKSTLEGIVFD 240 Query: 238 FSDAHGTLENLPLPLVPQPNAATALAAL-----RASGLEVSENAIRDGIASAILPGRFQI 292 G +NL + L+ AL + ++ A+ G+ +A GRF++ Sbjct: 241 CVTPKGIYKNLEIKLLGTHQVENALNCVYVYECLKEKYDIKTEALIKGLLNARWNGRFEV 300 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 + ++P V+ D AHN + L K + +++AV+G+L DK+ ++ +KSV Sbjct: 301 LIDTPLVVLDGAHNVDGMKVLVENCKIYLNDKKIVAVVGILKDKEYEKMISLIKSVAQRV 360 Query: 353 YCAPLEGP-RGATAEQLLEHLGN--GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 + R + ++ LE + +A A+ +D V++CGS + V Sbjct: 361 IFTLVPSQKRAFSEKEALEISHKCGVEFVPDFREAIKYALGLCNEDDAVIICGSLYLVGA 420 Query: 410 VMEVID 415 + Sbjct: 421 ARGFLK 426 >UniRef50_C7N4J3 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Slackia heliotrinireducens DSM 20476 RepID=C7N4J3_SLAHD Length = 427 Score = 478 bits (1231), Expect = e-133, Method: Composition-based stats. Identities = 125/427 (29%), Positives = 202/427 (47%), Gaps = 17/427 (3%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 T +YL + LGLER++ + RLG + A V +AGTNGKG+T Sbjct: 2 TQDIRDDAFDAHAYLNQSSWTQVKLGLERITTLLERLGHPEQAYPVVHIAGTNGKGSTSA 61 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTY 123 IL AAG++ G+++SP+++ + ER++V + + ++ + A + T Sbjct: 62 FTAGILQAAGFRTGLFTSPYILEFNERIQVNRENIGDADLHDIALAVRQAADGLEEEPTP 121 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T A F++A+ D+V+LEVGLGGR DATN+ V +T IA+DH LG Sbjct: 122 FELVTAVAFEYFRRAECDIVVLEVGLGGRYDATNVTTPAVCAITPIAMDHVGVLGNTLAE 181 Query: 184 IGREKAGIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 I EKAGI + P + +PE + I A+ GA + + Sbjct: 182 IAGEKAGIIKPGVPVVCYTQKPEAEAVIRAEARAIGAPV-MTPRFGRIHARMEGLQQVFS 240 Query: 242 HGTLENLPLPLVPQPNAATALAA------LRASGLEVSENAIRDGIASAILPGRFQIVSE 295 + + ++ L L+ A+ A LR G ++++ I+ G+ PGRF++V+ Sbjct: 241 YDGINDVKLRLLGAYQPCNAVMAIEIARTLRNQGFDIADEDIKRGLEETRWPGRFELVAT 300 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC- 354 P I D HN AE L ++ + V V+G+L DK + ++ + +YC Sbjct: 301 DPVTIVDGGHNEQGAEVLADSLRRYFPDTPVTFVMGVLKDKQYPQMINYVVPLAKRFYCA 360 Query: 355 APLEGPRGATAEQLLEHLGNGKSFD-----SVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 P E R +AE L + L + D S+A+A A A A +D V GS +++A Sbjct: 361 TPPESERALSAEDLAQALREAGAADARPCASIAEAVQTARAQAGPDDVVCCFGSLYSIAT 420 Query: 410 VMEVIDA 416 +M ++ Sbjct: 421 IMAALEG 427 >UniRef50_Q05865 Folylpolyglutamate synthase n=5 Tax=Bacillus subtilis group RepID=FOLC_BACSU Length = 430 Score = 475 bits (1224), Expect = e-132, Method: Composition-based stats. Identities = 121/429 (28%), Positives = 192/429 (44%), Gaps = 23/429 (5%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + S++ + GL R+ + ARLG + F VAGTNGKG+T + S Sbjct: 2 FTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAFHVAGTNGKGSTVAFIRS 61 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTY 123 +L AGY VG ++SP+++ + ER+ V G + + TA +++ + T Sbjct: 62 MLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVNQMKPHVEALDQTEYGQPTE 121 Query: 124 FEYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 FE T A F + ++D VI E GLGGR D+TN+V+ + V+TSI DH + LG E Sbjct: 122 FEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEPLLTVITSIGHDHMNILGNTIE 181 Query: 183 SIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGAL---LQRRGVEWNYS--VTDHD 235 I EKAGI + P + +PE I A+ A L V +N Sbjct: 182 EIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHAAPFQSLHDACVIFNEEALPAGEQ 241 Query: 236 WAFSDAHGTLENLPLPL---VPQPNAATALAALRASGLE----VSENAIRDGIASAILPG 288 ++F E++ L + NAA ++ A E +S+ A+R G+ A PG Sbjct: 242 FSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEWLNKENIAHISDEALRSGLVKAAWPG 301 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 R ++V E P V D AHN E L MK N R+ V L DK + L+++ Sbjct: 302 RLELVQEHPPVYLDGAHNEEGVEKLAETMKQRFANSRISVVFSALKDKPYQNMIKRLETI 361 Query: 349 VDDWYCAPLEGPRGATAEQL--LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 + A + PR + A+ L + N + + + + VL+ GS + Sbjct: 362 AHAIHFASFDFPRASLAKDLYDASEISNKSWSEDPDDVIKFIESKKGSNEIVLITGSLYF 421 Query: 407 VAHVMEVID 415 ++ + + + Sbjct: 422 ISDIRKRLK 430 >UniRef50_B8DZV7 FolC bifunctional protein n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8DZV7_DICTD Length = 443 Score = 474 bits (1220), Expect = e-132, Method: Composition-based stats. Identities = 127/438 (28%), Positives = 200/438 (45%), Gaps = 29/438 (6%) Query: 5 RTPQAASPLASWLSY---LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 + + L S+++Y L+N+ + LER+ + +G + F VAGT GKG Sbjct: 2 SYFERLNYLNSFINYEKRLDNITYEEKKFYLERMRYLLKLMGNPQDNLQAFHVAGTKGKG 61 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD--- 118 +T + SIL AGYKVG+Y+SPHL ER+ + + + + Sbjct: 62 STSAMIFSILKEAGYKVGLYTSPHLQSIRERISTHKGFISQEEFIDLIDYAKPYIEEAKK 121 Query: 119 ----ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHT 174 T+FE T A F +LD V++EVGLGGRLDATN+++ V+++T I DH Sbjct: 122 HPIFGPPTFFEVLTALAFLYFYIKKLDYVVIEVGLGGRLDATNVINPLVSIITPIGFDHM 181 Query: 175 DWLGPDRESIGREKAGIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEW----- 227 LG E I EKAGI + K I + + E IA VA+E+ A+ + + Sbjct: 182 HILGNTIEKIAFEKAGIIKEGKFVISSIQKEEAEKVIAKVAKERNAIYYKIDNLFKWERK 241 Query: 228 NYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAA-----LRASGLEVSENAIRDGIA 282 ++S+ + S E +PL+ + A+ A L L + +R+G Sbjct: 242 DFSLNGQRFLLSGKDIN-EEFFIPLLGEHQIVNAITAFGAIYLLRDKLSIDYETVREGFK 300 Query: 283 SAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTL 342 GRFQIVS+SP I D AHN +A L +K R+ + G++ DKD G L Sbjct: 301 KVQWMGRFQIVSKSPLTIIDGAHNVESAIALRDTLKNYVNFNRLFLICGLMKDKDAEGFL 360 Query: 343 AWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVA------QAWDAAMADAKAED 396 L +V + PL R + E+L + + + ++ +A + +A ED Sbjct: 361 KILNPLVYSYNFVPLSSHRTRSPEELGNIVKSFNADANINLHTNFYEAINFVKKEASPED 420 Query: 397 TVLVCGSFHTVAHVMEVI 414 +L+ GS + + Sbjct: 421 LILITGSLYLAGEALNYF 438 >UniRef50_B5YD69 Folylpolyglutamate synthase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YD69_DICT6 Length = 442 Score = 473 bits (1219), Expect = e-132, Method: Composition-based stats. Identities = 116/440 (26%), Positives = 197/440 (44%), Gaps = 29/440 (6%) Query: 6 TPQAASPLASWLSY---LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 + + + S+++Y L+NL + LER+ + +G + F +AGT GKG+ Sbjct: 2 YWDSLNYVNSFINYEKRLDNLTYEEKKFYLERMRYLLQLMGNPQDNLQAFHIAGTKGKGS 61 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD---- 118 T + SIL +AGYKVG+Y+SPHL ER+ + + + + Sbjct: 62 TSAMIFSILKSAGYKVGLYTSPHLQSIRERIATHEGFISQEEFVDLIDYAKPYIEEAKKH 121 Query: 119 ---ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTD 175 S T+FE T A F +LD V++EVGLGGRLDATN+++ ++++T I DH Sbjct: 122 PIFGSPTFFEVLTALAFLYFSMKKLDYVVIEVGLGGRLDATNVINPLISIITPIGFDHMH 181 Query: 176 WLGPDRESIGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYS--- 230 LG E I EKAGI + K I E I V++E+ A+ + +++ Sbjct: 182 ILGDTLEKIAFEKAGIIKEGKIVISSPQKKEAEEVIERVSRERNAVYYKVDDLFSWRKKE 241 Query: 231 --VTDHDWAFSDAHGTLENLPLPLVPQPNAATALAA-----LRASGLEVSENAIRDGIAS 283 + + E +PL+ + A+ A + + L + ++ G + Sbjct: 242 ANLDGQKFLLEGRDIK-EEFFIPLLGEHQIVNAVTAYGAIYVLKNRLNIDNEVVKKGFEN 300 Query: 284 AILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA 343 GRFQI++++P ++ D AHN +A L +++ R+ + G++ DKD L Sbjct: 301 VQWRGRFQIINKNPLIVVDGAHNVDSAMALKNTLESYVNFDRLFLICGIMKDKDAEKFLK 360 Query: 344 WLKSVVDDWYCAPLEGPRGATAEQLLEHLG------NGKSFDSVAQAWDAAMADAKAEDT 397 L +V + PL R T E+L + +D+ + A A D Sbjct: 361 ILDPLVYSYNFIPLPSHRTRTPEELANIVKVFRPNAEINIYDNFSSAISFVNKKASPADL 420 Query: 398 VLVCGSFHTVAHVMEVIDAR 417 +L+ GS + ++ R Sbjct: 421 ILITGSLYLAGEALDYFYGR 440 >UniRef50_C0GEY6 FolC bifunctional protein n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GEY6_9FIRM Length = 431 Score = 473 bits (1219), Expect = e-132, Method: Composition-based stats. Identities = 124/427 (29%), Positives = 205/427 (48%), Gaps = 22/427 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + ++ +L+ I+ GLER++ + RL + +AGTNGKG+T L S+L Sbjct: 3 YNEAIDWIHSLYRFGINPGLERITELLRRLEDPQKKIRCIHIAGTNGKGSTAAFLASMLE 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LTYFEY 126 A G +VG+Y+SP+L +T R+ + G ++ E+ +I +IS T FE Sbjct: 63 AQGLQVGLYTSPYLEAFTNRMAINGGDIDENRLAELVTQIRRHVEEISQTEAGQPTEFEV 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T A F + Q D VI+EVGLGGRLDATN+++ V+V+T+I L+HT LG +I Sbjct: 123 VTALAFLYFAEEQPDWVIMEVGLGGRLDATNVIEPAVSVLTNIGLEHTQVLGDTISAIAF 182 Query: 187 EKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYS-----VTDHDWAFS 239 EKAGI + PA+ + + VA E+GA L ++ Y + + + Sbjct: 183 EKAGIIKPSTPAVTAAEKEDALQVFRSVAVERGATLVEMDRDFGYEQLSASLDGQVFNYW 242 Query: 240 DAHGTLENLPLPLVPQP---NAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 L+NL + L+ NAA A+A + + +AI G+A+A PGR ++ S Sbjct: 243 SRQRKLDNLQISLLGPHQVRNAALAVATRELLPVPLDTDAIYRGLAAAKWPGRLEVFSRR 302 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD-WYCA 355 P V+ D AHN + L + + + V+G+L DK + L+ + + Sbjct: 303 PLVLVDGAHNIDGIKALKSALDTILDGRPLRLVLGILGDKAVDEILSLIVPLATAGLIVT 362 Query: 356 PLEGPRGATAEQLLEHLGNGKSFD-----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 + PR + ++ E S +V +A +A E+ + + GS +T++ Sbjct: 363 KPDNPRASNPREVAELARRYTSAPVAATDTVEEAVALGLAQTGEEEALCISGSLYTISEA 422 Query: 411 MEVIDAR 417 EV+ Sbjct: 423 REVLKKH 429 >UniRef50_C7H9L3 Tetrahydrofolate synthase n=2 Tax=Faecalibacterium prausnitzii RepID=C7H9L3_9FIRM Length = 423 Score = 472 bits (1217), Expect = e-132, Method: Composition-based stats. Identities = 125/419 (29%), Positives = 192/419 (45%), Gaps = 16/419 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+Y+ + GL R + LG VAGTNGKG+T L S L Sbjct: 3 YEEALNYIHAVQWAGHKPGLTRTRTLLTALGDPHKQLRFIHVAGTNGKGSTAAMLASCLQ 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS--LTYFEYGTLS 130 AAGY+VG+Y+SP + R+ ER++V GQ++P+ A ++ A ++ T FE T Sbjct: 63 AAGYRVGLYTSPFINRFNERIQVNGQQIPDEALVRLVERVKPAADAMTDIPTEFEIITAL 122 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWLGPDRESIGREKA 189 + F + + D+V+LEVGLGG LD+TN++D AV+T++ +DH LGP I KA Sbjct: 123 GMLWFAETKCDIVVLEVGLGGTLDSTNVIDPPECAVITALGMDHVKELGPTLADIASAKA 182 Query: 190 GIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 GI + P + G PE + IA A E+ A L + A + L Sbjct: 183 GIIKPGSPVVSYGGVPEADAVIARTAAERHAPLTVVDLSRLTIEDGDLDAVTFDFDGLNG 242 Query: 248 LPLPLVPQP---NAATALAALRAS---GLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 + LPL+ NAATA+ ALR G + ++AIR G+ PGRF+++ SP + Sbjct: 243 IRLPLIGSYQPRNAATAITALRVLRSRGWNIPDSAIRAGLEQVRWPGRFELLRHSPAFLL 302 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D +HN H ++ + + ++ ++ DKD+ LA L + + PR Sbjct: 303 DGSHNAHGMRATVQSLRDRFPGQKFVFLLSIMADKDVDEMLALLLPLAGQFVTVAAHTPR 362 Query: 362 GATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 AE L E + + ++ A+A V G+ + V E Sbjct: 363 AMPAETLAEQIRARGGRAEPAPTIEAGVARAVAL-GGTGPVCALGTLYFSGDVREAFAK 420 >UniRef50_B8FVG3 FolC bifunctional protein n=2 Tax=Desulfitobacterium hafniense RepID=B8FVG3_DESHD Length = 459 Score = 472 bits (1216), Expect = e-131, Method: Composition-based stats. Identities = 122/428 (28%), Positives = 200/428 (46%), Gaps = 25/428 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 YL +L ++ GL R+ + R+G + V + GTNGKG+T IL Sbjct: 28 YQEAKDYLVSLTKFGMNFGLGRIEELLKRMGNPEERLRVVHIGGTNGKGSTTMMTAEILE 87 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 AGY+VGV++SPHL Y ER+ + G+ +P+ T + ++ T FE Sbjct: 88 DAGYRVGVFTSPHLHDYRERITINGEMIPKGEVTRLIQILRPHLEELVQKGVEHPTEFEV 147 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T AL F ++D+V+LEVGLGG +D+TN+V ++V+T++ +DH D+LG E I Sbjct: 148 NTAMALMYFADQKVDLVLLEVGLGGAIDSTNVVKPLISVITNVGMDHMDYLGETYEEIAG 207 Query: 187 EKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT-----DHDWAFS 239 KAGI ++ + PE+ + I AQE + L G + + + + ++ + Sbjct: 208 VKAGIIKAGAITVTAADRPEVLNVIRKKAQEMNSPLWVVGDDVRWEIRWSGELEQEFDLA 267 Query: 240 DAHGTLENLPLPLVPQP---NAATALAALRAS----GLEVSENAIRDGIASAILPGRFQI 292 G L L LV + NAATA+ G+ + I +G+ A+ PGR ++ Sbjct: 268 GLRGAYNKLRLRLVGEHQVVNAATAVTVCELLKFEYGMNLERRNIYEGLRKAVWPGRLEL 327 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 +S P+V+ D AHN A L + + + R++ +GML DK+ + L + D+ Sbjct: 328 LSLKPKVLIDGAHNVDGAHALAKALN-IFQRQRLVLCLGMLGDKEREKVVDILVPLADEV 386 Query: 353 YCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 PR E L E + + + A + A ED + V GS + +A Sbjct: 387 IITKPNSPRSGNWEYLHELVKEKGKPVLTIEEPRLAVEEAFRRLDKEDMLCVTGSLYMIA 446 Query: 409 HVMEVIDA 416 + + Sbjct: 447 EARQALLD 454 >UniRef50_Q1JY09 FolC bifunctional protein n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1JY09_DESAC Length = 430 Score = 469 bits (1207), Expect = e-130, Method: Composition-based stats. Identities = 131/417 (31%), Positives = 197/417 (47%), Gaps = 15/417 (3%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + + L +L L I LGLE + + +G + + VAGTNGKG+ C L Sbjct: 1 MNTPDAALEFLYGLQMFGIKLGLENIQTLVDSVGQPQRNYGIVHVAGTNGKGSVCAFLGR 60 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 I AGY+VGVY+SPHL R+ ER+RV GQ + + A E+ ++ T+FE+ T Sbjct: 61 IYRQAGYQVGVYTSPHLHRFNERIRVNGQPIDDHDLVALVDELRQKNSEVPATFFEFTTA 120 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 AL F + +D+VILEVG+GGRLDATN+V V+V+T ++ DH D+LG I EK Sbjct: 121 LALLYFARQNVDLVILEVGMGGRLDATNVVAPLVSVITPVSDDHGDYLGGSLAEIAAEKG 180 Query: 190 GIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 GI + P ++G + + ++ A+E A G +++ T + Sbjct: 181 GIIKPGVPVVIGPQDKAAMAVLSARAKEMAAPCLCFGRDFSVEKTTSGCRVTTGALCWSE 240 Query: 248 LPLPL---VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 L L N A AL L G +V++ +R+ +A PGR + V E R++ Sbjct: 241 LQPSLPGRHQYDNLAVALMVVTHLAEQGWQVTQQVVREAVADTRWPGRLEWVGE--RILL 298 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D AHN A L ++ R+ V G DKD+ ++ L V YC + Sbjct: 299 DGAHNASGAHALADYLRGC-NVQRIHWVAGFKADKDMEAVVSSLLPFVVQAYCVEPPTEQ 357 Query: 362 GATAEQ----LLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 E L +H ++DS A +AA+ D V+V GS VA + + Sbjct: 358 AYPRENVVVHLQQHGCEASAWDSPTVALEAALQQCGDHDLVVVAGSLFLVAACRDWL 414 >UniRef50_C0QB10 FolC n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QB10_DESAH Length = 480 Score = 468 bits (1206), Expect = e-130, Method: Composition-based stats. Identities = 116/423 (27%), Positives = 202/423 (47%), Gaps = 20/423 (4%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L + I LGLE +S + LG + +AGTNGKG+ + SIL Sbjct: 52 SYEECLERMYKRGRFGIKLGLETISEILTNLGSPEKRFKSIHIAGTNGKGSIASYIASIL 111 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI-ESARGDISLTYFEYGTLS 130 AG+KVG+Y+SPHL+++ ER + G+E+ ++ ++ + ++ + T+FE T Sbjct: 112 KEAGFKVGLYTSPHLIKFNERFVINGREVSDNDIVEAYVALNKADTAERKATFFELATAI 171 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A +LF + ++ I+E G+GGRLDATNI+ ++V+++I+L+HT++LG E+I EK G Sbjct: 172 AFYLFAREGVEWAIIETGMGGRLDATNILLPKLSVISNISLEHTEYLGNTLEAIAMEKGG 231 Query: 191 IFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH--DWAFSDAHGTL- 245 I + + P + G + + + +AQ+ A L R +++ S + ++ T+ Sbjct: 232 IIKHKTPVVTGVNQENALAVLTKLAQKNMAPLYRLDNDFHVSQEPDRTRFTYNGIERTIT 291 Query: 246 --ENLPLPLVPQPNAATALAALRASGLE-------VSENAIRDGIASAILPGRFQIVSES 296 + L N+A A+AA+ +S+ I+ GI+ PGR + + ++ Sbjct: 292 GVQTRLPGLHQLDNSAIAIAAVELVFPPQKKQASVLSDEIIQRGISKTQWPGRLETIMQT 351 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P V+ D AHN AA L + + R+ V+G+L DKD + L D Sbjct: 352 PFVVIDGAHNLAAAINLARYFEEKFSDKRLTLVLGILDDKDFSSMLKQFVPWADRIIFTR 411 Query: 357 LEGPRGATAEQLLEHLG-----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 + R L + + V A A+A + ++D V + GS + Sbjct: 412 ADNKRSIDPHLLEQTARTLFTGEITVIEKVGDAVAHAIATSSSQDAVCIAGSLYVAGEAR 471 Query: 412 EVI 414 + I Sbjct: 472 KKI 474 >UniRef50_Q3AF86 Folylpolyglutamate synthase n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=Q3AF86_CARHZ Length = 432 Score = 468 bits (1206), Expect = e-130, Method: Composition-based stats. Identities = 116/429 (27%), Positives = 186/429 (43%), Gaps = 23/429 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L +L NL I+LGL R+S + RLG + V + GTNGKG+ C S+L Sbjct: 3 YNEALEFLSNLTKFGINLGLGRISELLKRLGNPQEKVKVVHIGGTNGKGSVCSLTASVLA 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEY 126 AGYK G+++SPHL RYTER ++ G+E+ + EI G T FE Sbjct: 63 EAGYKTGLFTSPHLSRYTERYKINGKEISPERVSQLVTEIRPLLLAMVEEGFEHPTEFEV 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIG 185 T A F + ++D V+LEVGLGG +D+TN+V +V +T++ +DH D+LG I Sbjct: 123 STAMAFKYFAEEEVDFVVLEVGLGGLIDSTNVVSRPEVVAITNVGMDHMDYLGNTITEIA 182 Query: 186 REKAGIFRSEKPAIVGEP-EMPSTIADVAQEKGALLQRRGVEW-----NYSVTDHDWAFS 239 R KAGI + P + E I +VA+EK + L + S+ + Sbjct: 183 RVKAGIIKPGVPVVTAATGEALEVIKEVAKEKNSPLLDVNKDIVLNLKEKSLKGQVFDLI 242 Query: 240 DAHGTLENLPLPLVPQPNAATA-----LAALRASGLEVSENAIRDGIASAILPGRFQIVS 294 T + + L+ A + + + AI G ++A GRF+ + Sbjct: 243 YRGETYPEIKIRLLGAHQLLNAKTSFGILNILREKYNIPVEAIYRGFSNATWSGRFEYIP 302 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 +P V+ D AHN L + + ++G+L DK+ +A L + + Sbjct: 303 GNPPVLLDGAHNHDGVRALRQAFTDYFPGVKPVLLLGVLADKEREKVVAELLDLPLEVVV 362 Query: 355 APLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKA-EDTVLVCGSFHTVAH 409 PR L K + +A + A+ + +L+ GS + + Sbjct: 363 TRPPTPRAGDITVLARLFKEKGVRVKVIEEPTEALSYGLEIAQEYQTLLLITGSLYMIGE 422 Query: 410 VMEVIDARR 418 + ++ R Sbjct: 423 IRPLLLQDR 431 >UniRef50_Q604P6 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Methylococcus capsulatus RepID=Q604P6_METCA Length = 431 Score = 467 bits (1203), Expect = e-130, Method: Composition-based stats. Identities = 185/418 (44%), Positives = 250/418 (59%), Gaps = 12/418 (2%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 S L WLS+ E LH + IDLGLERV V L + PF TV GTNGKG+ L++ Sbjct: 3 FSTLGEWLSWQETLHPQAIDLGLERVRRVYRALNPAQDRPFTITVGGTNGKGSCVAALDT 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 IL AGY+VG Y+SPH++RY ER+ + G + ++A ASF IE+ RGD +L++FE+GTL Sbjct: 63 ILRRAGYRVGAYTSPHILRYNERICIDGTPVDDAAICASFERIEAVRGDTTLSFFEFGTL 122 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +A+ +F++A+LDV ILEVGLGGRLDA NIVDAD A+V SI +DH +WLG RE+IG EKA Sbjct: 123 AAMDIFRRAELDVQILEVGLGGRLDAVNIVDADAALVASIGIDHEEWLGLTREAIGLEKA 182 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 GIFR +P I+G+P+ P+T+ A+ GA L +G ++++ + W + T LP Sbjct: 183 GIFRPARPCILGDPDAPATVLRHAEAIGADLLMQGRDFSFRRENDGWTWYGRGETHAALP 242 Query: 250 LP----LVPQPNAATALAALRA--SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 P N A L + A L V E A+R G+AS LPGRFQI P V+ DV Sbjct: 243 EPCLRGDHQYFNMAAVLQVIEAIRPRLPVPEAAVRAGLASVHLPGRFQIQEGEPTVLLDV 302 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 AHNPHA L ++ + V AV M+ DKDI G + ++ +VDDWY APL+ PR A Sbjct: 303 AHNPHAVRVLAEFLRQFKRGRPVHAVFAMMRDKDIRGVVECIRDLVDDWYLAPLQLPRAA 362 Query: 364 TAEQLLEHLGNGKS------FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 T E LL F A+ + +A+ + +LV GSF VA + I+ Sbjct: 363 TPEILLPVFSALGISQVQQGFADAAEVFARVRRNAENDSIILVFGSFFLVAEYLARIE 420 >UniRef50_P43775 Folylpolyglutamate synthase n=258 Tax=Gammaproteobacteria RepID=FOLC_HAEIN Length = 437 Score = 466 bits (1201), Expect = e-130, Method: Composition-based stats. Identities = 214/432 (49%), Positives = 277/432 (64%), Gaps = 25/432 (5%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 +A SPLA WLSYLE H K IDLGL+R+ VA +L +L P P+V TV GTNGKGTTCR L Sbjct: 7 KATSPLAEWLSYLEKSHFKPIDLGLDRIKSVAEKLDLLHPVPYVITVGGTNGKGTTCRLL 66 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 E+IL+ G +VGVYSSPHL+RY ERVR+Q Q+LP+ AHTASFA I+ SLTYFE+ Sbjct: 67 ETILLNHGLRVGVYSSPHLLRYNERVRIQNQDLPDEAHTASFAFIDE-NKTESLTYFEFS 125 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 TLSAL LFKQA+LDVVILEVGLGGRLDATNIVD+ +AV+TSI +DHTD+LG RE+I E Sbjct: 126 TLSALHLFKQAKLDVVILEVGLGGRLDATNIVDSHLAVITSIDIDHTDFLGDTREAIAFE 185 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 KAGIFR P ++GEP +P T+ D A++ + RR V+W + +W + + LEN Sbjct: 186 KAGIFRENCPVVIGEPNVPQTMLDQAEKLHCQVARRDVDWLFEQNAENWQWQNKKVRLEN 245 Query: 248 LPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES----------- 296 LP +P NAAT LAA++ ++SE +R + L GRFQ + Sbjct: 246 LPFCQIPLANAATVLAAVQYLPFDISEQTLRKSLQEVELVGRFQAIKTDKREKLADYLGV 305 Query: 297 -----PRVIFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVV 349 P +I DV HNPHAA+YL+ ++ AL + G+++AV GML DKD G L ++ Sbjct: 306 PVETLPTIIVDVGHNPHAAKYLSEKLTALKRSIEGKMIAVCGMLKDKDANGVFEHLTPII 365 Query: 350 DDWYCAPLEGPRGATAEQLLEHLG------NGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 D+W+C L G RG + ++L+E L S +SV A+ A D VLV GS Sbjct: 366 DEWHCVTLGGYRGQSGDELVEKLKSHFPNIQATSDNSVMDGVCTALKSAVKNDVVLVFGS 425 Query: 404 FHTVAHVMEVID 415 FHTVA V++ Sbjct: 426 FHTVAEFWAVVE 437 >UniRef50_B8DHJ7 Folylpolyglutamate synthase (Folylpoly-gamma-glutamatesynthetase) (Fpgs) (Tetrahydrofolate synthase)(Tetrahydrofolylpolyglutamate synthase) n=3 Tax=Listeria monocytogenes RepID=B8DHJ7_LISMH Length = 431 Score = 466 bits (1201), Expect = e-130, Method: Composition-based stats. Identities = 105/427 (24%), Positives = 196/427 (45%), Gaps = 23/427 (5%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 + L ++ I GL R+ + +L + A +AGTNGKG+T + Sbjct: 2 TLNSYEEALDWIHGTLRLGIKPGLARMEYMMEKLNHPEKANKWVHIAGTNGKGSTLTFIR 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLT 122 + L AGYK G ++SP++ + ER+ V G+ + + + I+ ++ + Sbjct: 62 NALEEAGYKTGTFTSPYIEVFNERISVNGEPISDELIVSLANRIKPIAEELEETIYGPPS 121 Query: 123 YFEYGTLSALWLFKQA-QLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 FE T F + +D+ I+EVGLGGRLD+TNI+ ++V+TSI +DH ++LG Sbjct: 122 EFEIITAMMFLCFAEYVSIDIGIVEVGLGGRLDSTNILMPLISVITSIGMDHMEFLGDTI 181 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS 239 E I EKAGI + P + G + E IA++A + + + ++ + + Sbjct: 182 EQIASEKAGIIKPGVPVVSGAIQKEAQEVIAEIATNNKSNVAQLYDSFSMVNKNGVITYK 241 Query: 240 DAHG-TLENLPLPLVPQPNAATALAALRASG-------LEVSENAIRDGIASAILPGRFQ 291 +G + +L + L+ A A++ + +AIR+G+ A PGR + Sbjct: 242 TIYGEEINDLSIGLLGIHQLNNAAIAIKVLQYLNTFSSFTIELSAIRNGLEKAFWPGRME 301 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV-D 350 V +P ++ D AHNP ++ P+ ++ V+ +L DK+ L L+++ Sbjct: 302 KVMSNPFIMLDGAHNPEGINTFARSIEMYPEPKKI--VVSILADKNYQEMLTTLRAISNS 359 Query: 351 DWYCAPLEGPRGATAEQLLEHLGN--GKSFDSVAQAWDAAMA-DAKAEDTVLVCGSFHTV 407 + PR T E++L+ + QA + +++++ + V GS + + Sbjct: 360 EIILTTFNYPRAMTTEEVLQIGEEEGISVNPNWQQALNNLYKGESESDAKIFVTGSLYFI 419 Query: 408 AHVMEVI 414 + V + Sbjct: 420 SEVRNYL 426 >UniRef50_A5I6P2 FolC bifunctional protein n=14 Tax=Clostridia RepID=A5I6P2_CLOBH Length = 429 Score = 465 bits (1198), Expect = e-129, Method: Composition-based stats. Identities = 108/431 (25%), Positives = 197/431 (45%), Gaps = 28/431 (6%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 Y+++ +LGLER + LG +AGTNGKG+T + ++ Sbjct: 1 MDYKEAREYIQSKAKFGSNLGLERTEKLLELLGNPHKRLRCIHIAGTNGKGSTTAMISAV 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LTYF 124 L +GYKVG+Y+SP++ + ER+++ G + + ++ + + T F Sbjct: 61 LKESGYKVGMYTSPYIEEFEERIQINGHNITKEDLGYIITKVANIVEKVENMGYGNPTEF 120 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T++ + F ++D ++EVGLGGRLD+TN+++ ++++TSI+ DH + LG E I Sbjct: 121 EIITVAMFYYFCLKEVDFAVIEVGLGGRLDSTNVLEPILSIITSISYDHMNILGETLEEI 180 Query: 185 GREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNY--------SVTDH 234 EKAGI + P I E+ I V +EK L + ++ Sbjct: 181 TYEKAGIIKK-APVITYPQKKEVEKNIEKVCKEKNCELIKVEDNLINIEIEIIEKNMGQQ 239 Query: 235 DWAFSDAHGTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPG 288 + T N+ L L+ + AL L G+++ + I + P Sbjct: 240 SFKLKTKEDTY-NICLSLLGEHQIKNCITVILALEKLMKLGIKIEKIHIISALKKVKWPA 298 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 R +IV+++P + D AHN E L + K +++ ++G+L DK + + L + Sbjct: 299 RLEIVNKNPLTVIDGAHNIDGIESLKNNVSKYFKYNKLILILGILKDKQVEDMIKTLVPL 358 Query: 349 VDDWYCAPLEGPRGATAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSF 404 D RG ++++L L+H + + + + +D A + D +L+CGS Sbjct: 359 ADRVLTVAPHNDRGESSKELMHIVLKHNESCEHLEDYKECYDKAKFYCEDGDMILICGSL 418 Query: 405 HTVAHVMEVID 415 + V + ++I Sbjct: 419 YMVGDMRKLIR 429 >UniRef50_B8I1X5 FolC bifunctional protein n=2 Tax=Clostridium RepID=B8I1X5_CLOCE Length = 424 Score = 465 bits (1198), Expect = e-129, Method: Composition-based stats. Identities = 113/423 (26%), Positives = 197/423 (46%), Gaps = 21/423 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + L YL GL+R++ + +G +AGTNGKG+T + SIL+ Sbjct: 3 YEAALEYLHGTLKFGSIFGLDRITKLLDLMGNPHKKLKFIHIAGTNGKGSTTAFISSILI 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 AGY+ G+++SP++ R+TER++V E+ ++I++ + T FE Sbjct: 63 EAGYRTGMFTSPYIQRFTERIKVDNNEISNDELAELISQIKNCIEKMVSNGFEHPTEFEI 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIG 185 T +++ F + + D+V+LEVGLGG +D+TN++D + +VVTSI++DH D LG I Sbjct: 123 ITAASMEYFYKKKCDIVVLEVGLGGIVDSTNVIDTPEASVVTSISMDHMDRLGETLGEIA 182 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRG----VEWNYSVTDHDWAFS 239 +KAGI + + ++ E E I V++EK A + + + +S+++ + + Sbjct: 183 YQKAGIIKQDGVVVLYPQEQEAEEVIERVSKEKNAQIHKVDFSTIYDKGFSLSEQIFDYK 242 Query: 240 DAHGTLENLPLPLVPQPNAATALAALRAS---GLEVSENAIRDGIASAILPGRFQIVSES 296 D L L NAA A+ G ++ I DG+ PGR +I++++ Sbjct: 243 DYRNIKIGL-LGDHQMRNAAVAIDTCELLCNKGFALTHRNILDGLEKTRWPGRLEIINKN 301 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P V+ D AHN + L + + + V+G L DKD G + L + D Sbjct: 302 PLVLIDGAHNLEGGQALNTALDKYFTQKKKIFVVGFLRDKDYIGIMDMLGNKADTIITVT 361 Query: 357 LEGPRGATAEQLLEHLGNGKSFD----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 R + +L E L + + S+ A+ A +E + GS + + + Sbjct: 362 PNNERAVPSAELAEILKSYSNHVVDGMSIENGLQTAVGLADSESVICAFGSLYMIGEIRG 421 Query: 413 VID 415 Sbjct: 422 HYK 424 >UniRef50_C0ZAJ3 Folylpolyglutamate synthase n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0ZAJ3_BREBN Length = 457 Score = 465 bits (1197), Expect = e-129, Method: Composition-based stats. Identities = 137/447 (30%), Positives = 196/447 (43%), Gaps = 37/447 (8%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 + L +L L GLER+ V ++G + VAGTNGKG+TC Sbjct: 2 HAEEGFVEYTQALDWLHGLLRFGQRPGLERMQWVLEQVGHPERRIPFIHVAGTNGKGSTC 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI-------ESARG 117 L +LM AGY VG ++SP+LV + ER+R G + E E+ E Sbjct: 62 AFLTQMLMEAGYSVGTFTSPYLVDFRERIRYNGSMIAEEDLLQLVNEVKVWVQRCEQETE 121 Query: 118 DISLTYFEYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDW 176 S T FE TL A+ F + A+ VV+ E GLGGRLD+TN+V V+V+T+I +DHT Sbjct: 122 YGSPTEFEVITLIAILYFSRVARPAVVVWETGLGGRLDSTNVVLPLVSVITNIGMDHTQV 181 Query: 177 LGPDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYS---- 230 LG E I REKAGI + P + GE PE+ + + A++ + L G + Sbjct: 182 LGESLEDIAREKAGIIKPGVPVVTGEVRPELLAVFEERARQMKSTLYHIGEHFQAEQVEE 241 Query: 231 -VTDHDWAFSDAHGTLE---NLPL-PLVPQPNAATALAALRASG----LEVSENAIRDGI 281 + D + + H E L + + NAA AL + + E I G+ Sbjct: 242 QLGDQQFGYKSIHRRAEASYRLTMNGIHQTTNAAVALMTIDVLRNYFSFLLEEEEISRGL 301 Query: 282 ASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNG-RVLAVIGMLHDKDIAG 340 PGR +++S P VI D AHN E L + L +G ++ + L DK +A Sbjct: 302 QQTRWPGRLEVISPRPMVILDGAHNQEGMEALVSSLDRLLPDGVQLHLLFSGLADKPLAK 361 Query: 341 TLAWLKSV---VDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQA----------WDA 387 L V + + + PR A A L E G A W Sbjct: 362 MAESLAPVKSKMKKLHVTTFDFPRAAEANSLQESFLAGGWEQEFLDAVPDWRAFLLSWMR 421 Query: 388 AMADAKAEDTVLVCGSFHTVAHVMEVI 414 AKA+D ++VCGS + +A V Sbjct: 422 EKQLAKADDWLVVCGSLYFIAQVRAFF 448 >UniRef50_B5EAK4 FolC bifunctional protein n=6 Tax=Geobacter RepID=B5EAK4_GEOBB Length = 424 Score = 464 bits (1195), Expect = e-129, Method: Composition-based stats. Identities = 132/419 (31%), Positives = 200/419 (47%), Gaps = 14/419 (3%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 A LS++ L + GL R+S + A LG + V GTNGKG+T L SI Sbjct: 1 MTYAETLSHIYALGRFGMKPGLSRISPLLAALGNPQERFRSVHVVGTNGKGSTASFLSSI 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L A GY+ G+++SPHL+ +TER+R+ G E+ + A + +A S T+FE T Sbjct: 61 LSAGGYRTGLFTSPHLISFTERIRIDGNEISQEDVVLVAARVMAAAPPES-TFFEIVTAL 119 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ F + ++V + E G+GGRLDATN +D + VT I+L+HT++LG I +EKAG Sbjct: 120 AVLYFAEKGVEVAVFEAGMGGRLDATNALDGILCAVTPISLEHTEYLGETLAEIAQEKAG 179 Query: 191 IFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 I + P + ++ + IA A E G+ L R+ ++ + TL++L Sbjct: 180 ICKPGAPLVSASQHADVEAAIATRADEIGSPLYRQQESFDAFWQGERLCYRGIGVTLDDL 239 Query: 249 PLPLVPQPNAATALAALRA------SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 + L + A AL G + A+ G+A A PGR ++ PRV+ D Sbjct: 240 KVGLFGRYQRGNAALALAVAELLGGLGFPLPPQAMAAGMARAFWPGRMELFPGPPRVLLD 299 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 AHNP A R+ V+G++ DK++ G L L + D +C R Sbjct: 300 GAHNPA-GANALAEALAEVPRARLFMVVGVMGDKELGGILGPLLPMADQVFCVTPALERA 358 Query: 363 ATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 AE++ + SV Q A + A ED +LVCGS TV + +R Sbjct: 359 LPAEEIARFCLAAGVPAQEAGSVTQGVQQAQSAAADEDLILVCGSLFTVGEARGYLLSR 417 >UniRef50_Q71ZB7 FolC bifunctional protein n=12 Tax=Listeria RepID=Q71ZB7_LISMF Length = 429 Score = 464 bits (1194), Expect = e-129, Method: Composition-based stats. Identities = 102/431 (23%), Positives = 198/431 (45%), Gaps = 25/431 (5%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 + L ++ I GL R+ + +L + A +AGTNGKG+T + Sbjct: 2 TLNSYEEALDWIHGTLRLGIKPGLARMEYMMEKLNHPEKANKWVHIAGTNGKGSTLTFVR 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLT 122 + L AGY+ G ++SP++ + ER+ + G+ + + + I+ ++ + Sbjct: 62 NALEEAGYRTGTFTSPYIEVFNERISINGEPISDEMIVSLANRIKPIAEELEKTIYGPPS 121 Query: 123 YFEYGTLSALWLFKQA-QLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 FE T F + +D+ I+EVGLGGRLD+TNI+ ++V+T+I +DH ++LG Sbjct: 122 EFEIITAMMFLCFAEYVSIDIGIIEVGLGGRLDSTNILVPLISVITTIGMDHMEFLGDTI 181 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS 239 E I EKAGI + P + G + E IA +A++ + + + + + + + Sbjct: 182 EQIASEKAGIIKPGIPVVSGAIQKEAQEVIAKIAKKNKSNVAQLNETFFMHNENGNITYK 241 Query: 240 DAHG-TLENLPLPLVPQPNAATALAALRASG-------LEVSENAIRDGIASAILPGRFQ 291 +G + NL + L+ A A++ E+ AI+ G+ A PGR + Sbjct: 242 TIYGEEISNLSIGLLGLHQLNNAAVAIKVLQYLNTFSTFEIGLAAIKKGLEKAFWPGRME 301 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD- 350 + +P ++ D AHNP + ++ ++ ++ +L DK+ L LKS+ + Sbjct: 302 KIISNPFIMLDGAHNPEGIKTFAHSIQKYSGPKKI--IVSILADKNYQEMLGMLKSIPNT 359 Query: 351 DWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMA---DAKAEDTVLVCGSFHTV 407 + + PR AE++++ N S+ W + + + + + GS + + Sbjct: 360 EIILTTFDYPRAMMAEEVIQIGKNEGI--SLNPDWQQVLGNLYETETNTKIFITGSLYFI 417 Query: 408 AHVMEVIDARR 418 + V + + A + Sbjct: 418 SEVRKYLLASK 428 >UniRef50_A8ZTL3 FolC bifunctional protein n=1 Tax=Desulfococcus oleovorans Hxd3 RepID=A8ZTL3_DESOH Length = 434 Score = 464 bits (1194), Expect = e-129, Method: Composition-based stats. Identities = 130/423 (30%), Positives = 197/423 (46%), Gaps = 16/423 (3%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 S + + NL I L L + + LG +AGTNGKG+ TL +I Sbjct: 5 SEYQRLIHEMYNLRRFGIKLELTTMQRMLDALGRPHTRYETIHIAGTNGKGSIATTLATI 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-SLTYFEYGTL 129 L AAGY+ G+Y+SPHLV + ER+++ + + +A + + GD T+FEY T Sbjct: 65 LHAAGYRTGLYTSPHLVTFNERIQINNRPVSNAAVVRACKAVRGLSGDGREPTFFEYTTA 124 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 A +LF + +D+ ++E G+GGR DATNI+ ++V+++I+++H +LG I EKA Sbjct: 125 MAFYLFAELGVDIAVIETGMGGRFDATNIITPCLSVISNISVEHRMYLGNTLGEIAGEKA 184 Query: 190 GIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSV-TDHDWAFSDAHGTLE 246 GI + P + G + + I VA+++ A L R G E+ D +++ + Sbjct: 185 GIIKPGVPVVTGARQKPVLDVIKKVAKKQAAPLYRLGGEFRVRRHGDGTFSYHGISHRWD 244 Query: 247 NLPL---PLVPQPNAATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 L NAA ALA L ASG +SE +R G+AS P R +IVS+SP ++ Sbjct: 245 RLRTVLAGGFQMDNAALALAGCELLMASGKPLSEATVRKGLASTRWPARLEIVSDSPTIL 304 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 D AHN AA+ L + ++ V G+L DK L L + D + Sbjct: 305 IDGAHNLQAAKNLAAFLSEQMAGRKITLVAGILDDKPYRAMLRALVPLCDRVILTRAQIG 364 Query: 361 RGATAEQLLEHLGNG-----KSFDSVAQAWDAAMADA-KAEDTVLVCGSFHTVAHVMEVI 414 R E L N D V +A A+A K V V GS + I Sbjct: 365 RAIAPEILEREARNLGATRTHVVDRVDKALAFALAHTPKKSGAVCVAGSLYVAGEARHAI 424 Query: 415 DAR 417 + Sbjct: 425 KKQ 427 >UniRef50_A0AJ00 FolC protein n=2 Tax=Listeria RepID=A0AJ00_LISW6 Length = 429 Score = 462 bits (1191), Expect = e-129, Method: Composition-based stats. Identities = 107/426 (25%), Positives = 192/426 (45%), Gaps = 23/426 (5%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 L ++ I GL R+ + +L + A +AGTNGKG+T + Sbjct: 2 TLKSYEEALEWIHGTLRLGIKPGLARMEYIMEKLNHPEKANKWIHIAGTNGKGSTLTFIR 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLT 122 + + AGY G ++SP++ + ER+ V G+ + + ++ ++ + Sbjct: 62 NCIEEAGYTTGTFTSPYIETFNERISVNGKPISDDKILILANRMKPIAEELKNTIYGPPS 121 Query: 123 YFEYGTLSALWLFKQAQ-LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 FE T F + +D+ I+EVGLGGRLD+TNI+ V+V+T+I +DH ++LG Sbjct: 122 EFEIITAMMFLYFAEYDSIDIGIIEVGLGGRLDSTNILLPLVSVITTIGMDHMEFLGNTI 181 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS 239 E I EKAGI + P I G + E I +A + A + ++ + F Sbjct: 182 EEIASEKAGIIKPGTPVISGVIQSEAQEVIKAIASKNKANFAQLNQDFFIQLDGKTATFK 241 Query: 240 DAHG-TLENLPLPL---VPQPNAATALAALRASG----LEVSENAIRDGIASAILPGRFQ 291 HG + +L L NA+ A+ ++ ++ E AI+ G+ A PGR + Sbjct: 242 TKHGEEIVDLVTGLDGFHQLNNASLAIKVIQYLNTYSLYDIDEKAIKAGLKKAFWPGRME 301 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD- 350 + E P +I D AHNP E L + + + ++ +L DK+ L+ LKS+ D Sbjct: 302 TILEKPLIIVDGAHNPEGIETLKHSINRFSGHK--IIIVSILKDKNYKEMLSSLKSIPDC 359 Query: 351 DWYCAPLEGPRGATAEQLLEH--LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 + + R +A++ + L + A + + +K + + + GS + ++ Sbjct: 360 EIILTTFDYSRAMSAQETINVGKLEDIAVNPVWHDAINDTVQ-SKNDSKIFITGSLYFIS 418 Query: 409 HVMEVI 414 V + + Sbjct: 419 EVRKFV 424 >UniRef50_A6TN35 FolC bifunctional protein n=2 Tax=Alkaliphilus RepID=A6TN35_ALKMQ Length = 439 Score = 462 bits (1190), Expect = e-129, Method: Composition-based stats. Identities = 119/427 (27%), Positives = 196/427 (45%), Gaps = 24/427 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+Y+ + + LGL+ + + L V VAGTNGKG+ + S+L Sbjct: 3 YEQALTYIHDTYKFGRKLGLDNIKYLLNLLDNPHQKVKVIHVAGTNGKGSIASLIHSVLK 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 GY+VG+Y+SP+L +TER+R+ G+++P E++ ++ T FE Sbjct: 63 TQGYRVGLYTSPYLEEFTERIRISGEDIPRERLAQVTEEVKMKIEEMVKSGQNHPTEFEV 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIG 185 T A + Q ++D V+LEVGLGGRLDATN+++ ++++T I DHT +LG + I Sbjct: 123 VTAIAFLYYAQEEVDFVVLEVGLGGRLDATNVINTPLLSIITPIGYDHTAYLGNTLKEIA 182 Query: 186 REKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVE----WNYSVTDHDWAFS 239 EK G+ + + +V E + ++QE+ L ++ ++ + ++ Sbjct: 183 FEKGGVIKEDGLTLVAPQEEEALQVLKKLSQERNNQLFMTNLQGLEIKKSTIEEQVFSCE 242 Query: 240 DAHGTLENLPLPLVPQPNAAT---ALAAL----RASGLEVSENAIRDGIASAILPGRFQI 292 EN+ + L+ AL A+ +EVS+ +I GI PGR ++ Sbjct: 243 TYARAYENVEIKLLGAHQIENCCTALTAIDILKEHHDIEVSDESIYQGILETRWPGRMEV 302 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 V + P VI D AHN + L +K L R+ V+GML DK++ G L L +VD Sbjct: 303 VQDEPTVIIDGAHNLQGGQALANTLKQLLSGRRITFVMGMLEDKEVDGFLNELIPLVDIV 362 Query: 353 YCAPLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 PR A L + V +A + +A +D +L GS + + Sbjct: 363 IATTPNSPRSMPANVLAGKMDVFKKPIHVEAEVRKAIEKGLALTGKDDVLLFAGSLYMIG 422 Query: 409 HVMEVID 415 V Sbjct: 423 EVRSYFK 429 >UniRef50_A8SN77 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SN77_9FIRM Length = 425 Score = 462 bits (1190), Expect = e-128, Method: Composition-based stats. Identities = 115/418 (27%), Positives = 194/418 (46%), Gaps = 16/418 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + + L + LGL+ + + +LG + + +AGTNGKG+ + S+L+ Sbjct: 3 YETAMIKLRGEVCSGVKLGLQNIKNLMEKLGNPQDKLKIIHIAGTNGKGSCTSFVNSVLV 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLS 130 + GYKVG+++SP + + ER+R+ + +PE E+ ++ FE T Sbjct: 63 SQGYKVGMFTSPSIYNFEERIRINNKNIPEDKLIELMNEVREIANTLEVFPADFELVTAL 122 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKA 189 A F + D I+EVGLGGRLDATN++ + ++TSI+ DH +LG + I EKA Sbjct: 123 AFLYFYRENCDFAIMEVGLGGRLDATNVINKPLITLITSISFDHQQFLGNTIKEIALEKA 182 Query: 190 GIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 GI + P + + E+ I VA+ K + + + + + + +N Sbjct: 183 GIIKDGVPLVLYSQDTEIMDNIMGVAKSKNSKVIVNDLSKIKVLENKKSGQVIDYKDFKN 242 Query: 248 LPLPLVPQPNAATA------LAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 L + L+ A L LR G E+S +I +G ++ P RF++VS+SP I Sbjct: 243 LKINLLGSHQVKNATISLELLLELRKIGFEISNESIYNGFSTVTWPCRFELVSKSPDFIL 302 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D AHN E M KN + +A+ G+L DKD L + D + + R Sbjct: 303 DGAHNIDGIEKFVSNMNFYYKNNKKIAIFGVLADKDYNEMLEKIVPCFDVFLTVRPDSER 362 Query: 362 GATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 A +L E + SF++ +A D A + +D + GS + V + +++ Sbjct: 363 AMEAYELKEKIEALTEKKVYSFENYQEAIDKAFEISSKDDVISAFGSLYFVGEIRKLL 420 >UniRef50_B9XQF6 FolC bifunctional protein n=1 Tax=bacterium Ellin514 RepID=B9XQF6_9BACT Length = 435 Score = 462 bits (1189), Expect = e-128, Method: Composition-based stats. Identities = 136/423 (32%), Positives = 195/423 (46%), Gaps = 27/423 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + +L NL LGLE +A G + VAGTNGKG+TC LESI Sbjct: 3 YPEAIQFLYNLQVFGTKLGLENTYRLAKLAGNPQEKLRFIHVAGTNGKGSTCAMLESIYR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS----LTYFEYGT 128 AG KVG+++SPHLV + ER+++ + + E E+++ + T+FE T Sbjct: 63 HAGLKVGLFTSPHLVAFGERIQINRELISEEEIIRLVEEMKALLQEFPADEHPTFFEVVT 122 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 + AL F + + DVVI E GLGGRLDATNIV V+V+T+I DH WLG I EK Sbjct: 123 IMALSYFARQKCDVVIWETGLGGRLDATNIVTPLVSVITNIQFDHQKWLGDTLAKIAFEK 182 Query: 189 AGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 AGI + P I +PE + AQEK A WA ++ Sbjct: 183 AGIIKPRVPVITAVDDPEALRILFKTAQEKAAPFSLI-----------TWA-QTEFHPMQ 230 Query: 247 NLPLPLVPQP---NAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSE--SPRV 299 L LPL+ + NAATA+ A+ A+ + VS+ IR G++ PGR Q+V +V Sbjct: 231 GLTLPLLGEHQRLNAATAVHAVMAARSCIPVSDETIRKGLSGVKWPGRLQLVERKNGQKV 290 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 + D AHN +AE L + R V+G+L DKD + + P+ Sbjct: 291 LLDGAHNIGSAEALKTALNTYFATRRPTLVMGILSDKDAHPMCEIIAPLAGRILLVPVNS 350 Query: 360 PRGATAEQLLEHLGNGKSFDSVAQA--WDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 R +L+ V + A+ A + V V GS + + ME++ Sbjct: 351 QRTILPRELIPVCRRANPDVEVRECRSLKEALDVAAEDPFVAVTGSLYLIGEAMELLGLS 410 Query: 418 RSG 420 +G Sbjct: 411 PAG 413 >UniRef50_D2RP25 FolC bifunctional protein n=2 Tax=Acidaminococcus RepID=D2RP25_ACIFE Length = 426 Score = 462 bits (1189), Expect = e-128, Method: Composition-based stats. Identities = 127/423 (30%), Positives = 199/423 (47%), Gaps = 21/423 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 ++ ++Y+E+L I LG+ER+ + A L + V GTNGKG+ L ++ Sbjct: 1 MEYSAAVTYVESLGKFGIHLGMERIQGLTALLDHPERKIRTIHVTGTNGKGSVTTFLANM 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYF 124 L AG KVG Y+SPH VRY ER+ + G+E+ A ++A G T F Sbjct: 61 LQQAGKKVGSYTSPHFVRYNERICLNGEEISNEDFAAVTERTKAALDRFLAEGGEQPTQF 120 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E+ T A F + Q+D ++EVG+GG D+TNI+ +V+V+T++ L+HTD LG E+I Sbjct: 121 EFITAMAFLYFAEKQVDYAVIEVGMGGLWDSTNIITPEVSVITNVTLEHTDRLGKTIEAI 180 Query: 185 GREKAGIFRSEKPAIV-GEPEMPSTIADVAQEKGALLQRRGVEWNYS-----VTDHDWAF 238 +KAGI + P + E + I A+ A L G +++ + + + Sbjct: 181 AAQKAGIIKPGVPVVTEAEGKALEVIRGTAEASHAPLYVYGDDFSTEELTSSMDAQTFLY 240 Query: 239 SDAHGTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQI 292 +E + + L + A LR + E A+ G+ +A PGR + Sbjct: 241 RMGEKEME-VTIHLPGEHQILNGAAALAAAEILREKDGSIDEAAMLRGMDAARWPGRLER 299 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 + +P +I D AHNP L + R + V GM+ DKD++ L D Sbjct: 300 IHRNPDIILDGAHNPSGVTVLRKALDEYYPGARRIYVFGMMADKDVSQVSEILFRPEDTI 359 Query: 353 YCA-PLEGPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 Y EG R E+L L N D +A A+ A+ +A ED V+VCGS + + Sbjct: 360 YTVLAHEGDRSEKPEKLARRLHKNAVPMDELAAAYRRAVQEAGPEDVVIVCGSLYLIGTF 419 Query: 411 MEV 413 E+ Sbjct: 420 KEL 422 >UniRef50_A8FFU4 Tetrahydrofolate synthase n=88 Tax=Bacillaceae RepID=A8FFU4_BACP2 Length = 434 Score = 461 bits (1188), Expect = e-128, Method: Composition-based stats. Identities = 114/429 (26%), Positives = 189/429 (44%), Gaps = 24/429 (5%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + + ++ + + + GLER+ + +L + VAGTNGKG+T S Sbjct: 4 FTTYHEAIEWIHSRLAFGVKPGLERMKWLMNKLSHPEQRIKAVHVAGTNGKGSTIAFTRS 63 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LTY 123 +L AAGY VG ++SP ++ + ER+ V G + + + +I+ ++ T Sbjct: 64 VLQAAGYSVGTFTSPFILTFNERISVNGAPIQDEEWLSLVNKIKPFVDELDQTELGAATE 123 Query: 124 FEYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 FE T A F Q+D V+LE GLGGRLD+TN+ + +TSI DH LG E Sbjct: 124 FEIITACAFAYFADVQQVDFVLLETGLGGRLDSTNVAAPILTAITSIGHDHMAILGDTLE 183 Query: 183 SIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGV-----EWNYSVTDHD 235 I EKAGI + P I +PE + I ++A+EK A + T Sbjct: 184 QIASEKAGIIKVGIPMITAVHQPEALAVIQNIAKEKKAECISLQETCTFSHQQPTETGEQ 243 Query: 236 WAFSDAHGTLENLPLPL---VPQPNAATALAALRASG----LEVSENAIRDGIASAILPG 288 + + + L L + NA+ A+ + + V+E + +GI A+ G Sbjct: 244 FTLNTSKRQYPQLETGLIGTHQRQNASLAVLLIEWLEQEGYISVTEEQVYEGIRHAVWAG 303 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 RF+ V + P V D AHN + L ++A + +V L DK + L++V Sbjct: 304 RFEKVKDHPPVYLDGAHNEEGIDRLIETVQAHFSSKQVHICFSALKDKPYKQMIQKLEAV 363 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLG-NGKSFDSVAQA-WDAAMADA-KAEDTVLVCGSFH 405 + + PR +AE+L KS+D +A + + +LV GS + Sbjct: 364 SSSIHFVSFDFPRAESAEKLYACSQLEAKSYDDDPRAVLEWIQKKSDDPSAVILVTGSLY 423 Query: 406 TVAHVMEVI 414 ++ + + Sbjct: 424 FISDIRNRM 432 >UniRef50_A8UBK8 Folyl-polyglutamate synthetase n=1 Tax=Carnobacterium sp. AT7 RepID=A8UBK8_9LACT Length = 434 Score = 461 bits (1188), Expect = e-128, Method: Composition-based stats. Identities = 107/430 (24%), Positives = 197/430 (45%), Gaps = 23/430 (5%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + L+++ + GL+R+ + +++G + +AGTNGKG+T L Sbjct: 2 FATYEEALNWIHTTRTFGKKPGLKRMEWMLSQVGHPERKFKSIHIAGTNGKGSTLAFLRG 61 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTY 123 +L A G VG Y+SP++ + ER+ V G L ++ + ++ + Sbjct: 62 MLEANGQIVGTYTSPYIELFNERISVNGDPLSDAEILRLANIVYPLTKELEKTILGEPSE 121 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T+ L F + DVV++EVG+GG D+TN++ V+V+T+I LDH + LG Sbjct: 122 FEIITMMMLLYFGEGHADVVLIEVGIGGTYDSTNVITPIVSVITTIGLDHMNLLGDTLSE 181 Query: 184 IGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYS------VTDHD 235 I KAGI ++ P ++G+ E + I + A E+ + L + ++ + Sbjct: 182 IAGNKAGIIKATVPVVIGKIGKEAMTVIENKAAEQDSTLLKYNQDFFVTKWQTLPTWGEQ 241 Query: 236 WAFSDAHGTLENLPLPLVPQPNAATALAALRAS-------GLEVSENAIRDGIASAILPG 288 + F D L + + ++ + A A+ GL ++ + G+ PG Sbjct: 242 FVFEDDFIRLSPIQIEMLGRHQVENAAVAVETLRVYSHETGLAINHEKLLSGLKHTFWPG 301 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 RF+ ++E P ++ D AHN HA + L +K V ++ + DK+I G + L+ + Sbjct: 302 RFERINEQPLLVLDGAHNEHAMKTLIETIKKNFAQQEVYIIMATMRDKNIQGMVDQLEEI 361 Query: 349 V-DDWYCAPLEGPRGATAEQLLE-HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 + PR A E+L + L NG + +A ++ + VLV GS + Sbjct: 362 PNSHLILTSFDYPRAAGIEELSKVALKNGAVTEHWQKALVDSLNEMDETGIVLVTGSLYF 421 Query: 407 VAHVMEVIDA 416 ++ V + ++ Sbjct: 422 ISEVRKYLNE 431 >UniRef50_C7MLS9 Folylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Coriobacteriaceae RepID=C7MLS9_CRYCD Length = 466 Score = 460 bits (1185), Expect = e-128, Method: Composition-based stats. Identities = 138/449 (30%), Positives = 212/449 (47%), Gaps = 36/449 (8%) Query: 3 IKRTPQAASPLASW--LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 I T A + ++ ++YL ++ LGLER+ + A LG + V VAGTNGK Sbjct: 23 ISDTIDTADAVDTFDPIAYLNEPRWRSSRLGLERIESLMAALGNPQDKLTVVHVAGTNGK 82 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI- 119 G+TC + S+L AGY+ G+++SP+++ +T+R+R+ GQ + +A A+ + + Sbjct: 83 GSTCAMVASVLQHAGYRTGLFTSPYIIEFTDRIRIDGQNVSLAALCAATQTVRRVAEQMD 142 Query: 120 -SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWL 177 T FE T A F A + ++EVGLGGRLD+TN++ V + I+ DHTD L Sbjct: 143 DHPTEFELMTAVAFVCFVAAGCTMAVVEVGLGGRLDSTNVIAAPAVCALAPISFDHTDIL 202 Query: 178 GPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD 235 G I EKAGI + + PE I + A + G+ + E S T Sbjct: 203 GSTLAQIAHEKAGIIKPGAAIVSALQRPEAMRVIENAALQVGSPVTVVD-EQRLSGTPAH 261 Query: 236 WAFSDAHGTLENLPLPL---VPQPNAATALAALRAS---GLEVSENAIRDGIASAILPGR 289 +++ +L +PL NAA A+ A+ A G+ ++E +R+G+A PGR Sbjct: 262 FSYRS----YTDLSIPLKGSYQTHNAALAIEAIDALIQKGITITEQDLREGLAQVSWPGR 317 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 FQ+VS SP I D HNP A+ L ++A R + +IG+L DKD+ L + Sbjct: 318 FQVVSHSPEFIVDGGHNPQGAQALVDSLEANYPARRTVLLIGVLADKDVTSMLRRVLPSG 377 Query: 350 DDWYCAPLEGPRGATAEQLL------------------EHLGNGKSFDSVAQAWDAAMAD 391 C PR A++L E L N S+ Q A Sbjct: 378 CGVVCITPPNPRALGAQELASQVVSLAKQLQNESIAIDERLLNPVCAPSIGQGVTCAQQM 437 Query: 392 AKAEDTVLVCGSFHTVAHVMEVIDARRSG 420 A AE V GS +++A +M +D + Sbjct: 438 AGAEGLVCAFGSLYSIADIMAALDKHSAD 466 >UniRef50_A6C8Q2 Folyl-polyglutamate synthetase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C8Q2_9PLAN Length = 477 Score = 460 bits (1184), Expect = e-128, Method: Composition-based stats. Identities = 119/458 (25%), Positives = 194/458 (42%), Gaps = 48/458 (10%) Query: 5 RTPQAASPLASWLSY--LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 + Q+ L L+Y + + T D L R+ + LG + +AGT GKG+ Sbjct: 7 KYQQSLDFLFGRLNYERMGSSKYSTSDFKLGRMQELLESLGNPQSEVRTIHIAGTKGKGS 66 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI--- 119 T + +L AAG++ G+++SPH+ Y ER+ + G+++ +E+ + Sbjct: 67 TSAMIAEMLSAAGFRTGLFTSPHITCYEERILIDGRQIEPEQLVDLVSELIQVVEQLDLK 126 Query: 120 ----SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTD 175 S T+FE T A F+Q ++D ++EVGLGGRLD+TN+ + +VVT+I+ DHT Sbjct: 127 PGNLSPTFFELTTALAWMHFQQQRVDFAVMEVGLGGRLDSTNVCEPLASVVTNISYDHTA 186 Query: 176 WLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTD 233 LG E I REKAGI + P G +PE + + +V +EK A L ++ V Sbjct: 187 LLGNTIEQITREKAGIIKQGVPVFSGVTQPEAMAVLEEVCREKQAPLYLLNRDFKRLVEP 246 Query: 234 --------------------HDWAFSDAHGTLENLPLPLVPQPNAATALAA------LRA 267 ++ +P+ L+ A A LR Sbjct: 247 YQGFRREQADDSRLFPDSNQQTIQVRTPWSLIDQMPVTLLGTHQLINATLAVTVIDFLRQ 306 Query: 268 SGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVL 327 G+ + ++ +R G+ P R ++V ++P V+ D AHN + E L + A + Sbjct: 307 QGVPLEDSQMRQGMTRLKWPARIELVQKNPPVVIDTAHNGASIEALVETLAASFPQTNRI 366 Query: 328 AVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQLLEHLGNGK---------- 376 + DKD+ L L PR E+L+E + Sbjct: 367 LIFAATKDKDVGEMLETLLPSFQTVILTQYRSNPRRIPVEELVELTRAVQLSTGNTSQLS 426 Query: 377 SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 DS AW A + + V GSF A + E++ Sbjct: 427 ITDSPEAAWLQAKDMLTPDTLICVTGSFFIAAELRELL 464 >UniRef50_D0WG21 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Slackia exigua ATCC 700122 RepID=D0WG21_9ACTN Length = 442 Score = 459 bits (1183), Expect = e-128, Method: Composition-based stats. Identities = 134/420 (31%), Positives = 202/420 (48%), Gaps = 17/420 (4%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 +YL+ + +DLGL+R + A LG + A + VAGTNGKG+T + IL AA Sbjct: 21 DAKAYLQQGSWRDMDLGLDRTRALLAALGNPQDAYPIVHVAGTNGKGSTSAFIAGILQAA 80 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSAL 132 GY G+++SP ++R+ ER++V ++ + + A D+ T FE T AL Sbjct: 81 GYDTGLFTSPFILRFNERIQVNRVDISDGELDEVARAVRDAAASIDVHPTAFELITAVAL 140 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F++ D V+LEVGLGGRLDATN+V +TSIA DH LG I EKAGI Sbjct: 141 EHFRRRGCDAVVLEVGLGGRLDATNVVVPAACAITSIAFDHMRILGDTLAQIAAEKAGIV 200 Query: 193 RSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 + P + PE + I D + G++L V ++ ++ + ++ L Sbjct: 201 KPGVPVVSYRQAPEAQAVIEDACRAAGSVL-VFPRFGRIHVRQEGFSQVFSYDGIADVRL 259 Query: 251 PLVPQPNAATALAA------LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 L+ A+ A LR GL +S++AI+ G+ + PGRF++V+ SP I D Sbjct: 260 SLLGTYQPCNAVMAIEVARVLRTRGLAISDDAIKRGLETTRWPGRFELVAASPTTIVDGG 319 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP-RGA 363 HN A L ++A + V V GML DK +A + + YC P R Sbjct: 320 HNEQGAAMLASSLRAYFPHRTVTFVAGMLKDKRYRDMVALVAPLAAKVYCVEPPEPERAL 379 Query: 364 TAEQLLEHLGNGKSFD-----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 A L + D S+A A A+A +D V GS ++++ VME + + R Sbjct: 380 PAADLAQEFVRAGVADTVACASIADGVHRARAEASPDDVVCCFGSLYSISEVMEALGSSR 439 >UniRef50_Q1PZI3 Similar to multifunctional folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZI3_9BACT Length = 464 Score = 457 bits (1178), Expect = e-127, Method: Composition-based stats. Identities = 120/446 (26%), Positives = 194/446 (43%), Gaps = 32/446 (7%) Query: 1 MIIKRTPQAASPLASWLSY--LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTN 58 + ++ +A + L + L Y L + T L+R+ + ++G + GT Sbjct: 11 LCLRSYEEACAFLNTSLDYEKLISYQYNTSTFNLDRMVRLLEQVGNPHREFSSLHITGTK 70 Query: 59 GKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASF-------AE 111 GKG+T L ++L AGYK G+++SPHL ER+++ ++PE TA+ Sbjct: 71 GKGSTAIMLSTVLQRAGYKTGLFTSPHLTNLKERIQLNHTKIPEEDFTAALNVLVPDIQR 130 Query: 112 IESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIAL 171 + + S T+FE T FK+ Q ++ +LEVG+GGRLDATN+V V+V+T+I L Sbjct: 131 LRNTTPAESPTFFETLTAICFLYFKEKQAEMAVLEVGMGGRLDATNVVLPLVSVITNIGL 190 Query: 172 DHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY 229 DH + LG I EKAGI + P I +PE S I +V EKGA L G + Sbjct: 191 DHVNILGNTIPRIAYEKAGIIKKGIPVISAAEKPEALSVIKEVCMEKGAPLYLLGKDIRI 250 Query: 230 S---------VTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASG-------LEVS 273 G NL +PL+ A AL A + + Sbjct: 251 DDAQPYTNKNSRGLLCNIKTWQGVYGNLFIPLMGIHQAKNCAMALGALDVLREHGKISID 310 Query: 274 ENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGML 333 IR+ PGR +++ E+P ++ D AH + L + +++ ++G Sbjct: 311 NETIREAFTHVRCPGRIEVLGETPLIVLDFAHTVESMAALRETLFEHFTFNKLVVILGFS 370 Query: 334 HDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAA 388 DKDI L + +D + R E+L + + + +S A AA Sbjct: 371 QDKDIDNILREIVPCANDIFVTKSTNSRAVPPEELAKKIKAVYGKRAEICNSARDAVIAA 430 Query: 389 MADAKAEDTVLVCGSFHTVAHVMEVI 414 A +D + + GS + V + + Sbjct: 431 QHAASPDDLLCITGSAYIAGEVRQEL 456 >UniRef50_C8QY00 FolC bifunctional protein n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QY00_9DELT Length = 453 Score = 457 bits (1177), Expect = e-127, Method: Composition-based stats. Identities = 129/447 (28%), Positives = 193/447 (43%), Gaps = 40/447 (8%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 YL+ L I LGL+ + ARLG + VAGTNGKG+ L ++ Sbjct: 1 MDYQQAWDYLDRLQFFKIKLGLDSMERFLARLGKPQQQLRFIHVAGTNGKGSVAAALLAV 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L AGY+VG+Y+SPHL ER R+ + + + I GD +TYFE+ T Sbjct: 61 LSRAGYRVGLYTSPHLSCVRERFRINDEFIGKDEFARHATAIHEVLGDDQITYFEFTTAL 120 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 AL F ++DV ILEVGLGGRLDATN++ +V V+T+++LDH +LG + EKAG Sbjct: 121 ALLWFAARRVDVAILEVGLGGRLDATNVITPEVGVITNVSLDHQAYLGDTLAEVAAEKAG 180 Query: 191 IFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD------------- 235 I ++ P + G E + + A G ++++ D Sbjct: 181 IIKAGVPLVTGVAADESREVVEQRCRLLKAPCYLLGRNFSWAYGDDRQARQDSAQSVSDS 240 Query: 236 --------WAFSDAHGTLENLPLPLVPQPNAATALAALRASG-----LEVSENAIRDGIA 282 W + +G + L L + AL V+E +IR GIA Sbjct: 241 AAAAAGNLWHYRGLNGEISGLQCRLRGRHQRDNLSLALATLELLAPIWPVTEESIRAGIA 300 Query: 283 SAILPGRFQIVSESP-------RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHD 335 + PGR + + P RV+ D AHNP L G ++ R++ V + D Sbjct: 301 AVNWPGRLEYLEIRPAGADGRRRVLLDGAHNPAGIGALVGALQEDFSYRRLVVVWASMAD 360 Query: 336 KDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG-----NGKSFDSVAQAWDAAMA 390 KD+A L + + D+ E R AT + + L + + A A A Sbjct: 361 KDVAAGLQQIAPLADELVLTRPESERSATPAAMRQMLPPATRTAAREAEDTAGALQLAWQ 420 Query: 391 DAKAEDTVLVCGSFHTVAHVMEVIDAR 417 + +D VLV GS + V ++ Sbjct: 421 ASTPDDLVLVAGSLYLVGAARRLLQGE 447 >UniRef50_B6J6W5 Folylpolyglutamate synthase n=6 Tax=Coxiella burnetii RepID=B6J6W5_COXB1 Length = 416 Score = 457 bits (1177), Expect = e-127, Method: Composition-based stats. Identities = 177/416 (42%), Positives = 257/416 (61%), Gaps = 7/416 (1%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + +WL+Y+ +LHS+ IDLGL R++ +A +L + A V TVAGTNGKG+ ++LESI + Sbjct: 1 MKNWLAYINSLHSREIDLGLSRITSLAEKLSLNNFACPVVTVAGTNGKGSVVKSLESIYL 60 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AAGYKV Y+SPHL+++ ER+R+ G+ + +F IE R L++FE+ TL+ Sbjct: 61 AAGYKVAAYTSPHLLQFNERLRLNGEPATDELFIEAFKFIEDNRNHQPLSFFEFTTLAIF 120 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 ++ K+ LD+++LEVGLGGRLDA NIV+ DVAV+T+I +DHTDWLG DRESIGREKAGI Sbjct: 121 YICKKQNLDILLLEVGLGGRLDAVNIVEPDVAVITTIDIDHTDWLGEDRESIGREKAGII 180 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 R KP I G+P +P+++ + A + ++ T +W + + LPLP Sbjct: 181 RRHKPVIGGDPNLPNSVYEQVHLLEAPFYQLEKDFFAVSTKENWQWQGPTQDYQGLPLPS 240 Query: 253 VPQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 + N AT+L + L VS++++ GI +A+LPGRF+ + ++FDVAHNP A Sbjct: 241 LKIENIATSLMVIHCLQSQLPVSQHSLIAGIKNAVLPGRFEWIQTPAPIVFDVAHNPQAT 300 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 YL+ +++ GR L V+GML DKDI G L + +D WY L RGAT+ L Sbjct: 301 AYLSEQLRKTDHAGRTLGVVGMLRDKDIPGALKPMLPCIDQWYAGTLSESRGATSANLQN 360 Query: 371 HLG-----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSGG 421 L N FDSVA A+ A+ D + +D ++V GSF+TVA EV+ +G Sbjct: 361 VLSELQVENCYDFDSVADAFKKAVEDCRPQDRIVVFGSFYTVAMAKEVLLGGENGN 416 >UniRef50_Q9K8G9 Folyl-polyglutamate synthetase n=1 Tax=Bacillus halodurans RepID=Q9K8G9_BACHD Length = 430 Score = 456 bits (1175), Expect = e-127, Method: Composition-based stats. Identities = 121/425 (28%), Positives = 195/425 (45%), Gaps = 22/425 (5%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 + ++ + I GL+R+ + +LG + V + GTNGKG+T + +L A Sbjct: 6 QAIEWIHSFLPFGIKPGLQRIEWMLEKLGHPEKELNVVHIGGTNGKGSTVSFMRCMLTEA 65 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYGT 128 GY VG ++SP++ + ER+ +G+ + S I ++ S T FE T Sbjct: 66 GYNVGTFTSPYIEHFRERIAYKGEPISSEELVRSCLNIIDVVEELKRTDLGSPTEFEVIT 125 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 + A F + D+V+LEVGLGGRLD+TNIV ++++TSI DH + LG ESI EK Sbjct: 126 VIAFDFFARVNPDIVLLEVGLGGRLDSTNIVTPLLSIITSIGHDHMNVLGGTLESIAYEK 185 Query: 189 AGIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEW-----NYSVTDHDWAFSDA 241 AGI + + PAI V +PE I D A + A L G ++ + ++ +++ Sbjct: 186 AGIIKPDIPAIVHVKQPEAFRVIQDKANKVKAPLFAYGTDFHSLPKSVTMDKQFFSYQSQ 245 Query: 242 HG---TLENLPLPLVPQPNAATALAALRASG----LEVSENAIRDGIASAILPGRFQIVS 294 G +LE + NA+ A+ A+ E+S + I GI + GRF+ +S Sbjct: 246 SGLTLSLETVMKGHHQIENASMAIQAIEQLRSMKHYELSNDHIVRGIRNTTWIGRFEKIS 305 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 E+P D AHN + L + + V+ + +K++ LA + + Sbjct: 306 EAPLTFVDGAHNEEGMKALAELLALHFPTYKYRFVMAVTKEKEMKALLAPYVDLPASFTF 365 Query: 355 APLEGPRGATAEQLLEHLG--NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 E R AEQL E N A KA + V++CGS + ++ V Sbjct: 366 TTFEFERAQKAEQLYEQAPVYNKSICADWKVAIRRERESCKANEMVIICGSLYFISKVRA 425 Query: 413 VIDAR 417 + R Sbjct: 426 FLLER 430 >UniRef50_Q02Z16 Folylpolyglutamate synthase n=20 Tax=Bacteria RepID=Q02Z16_LACLS Length = 427 Score = 456 bits (1174), Expect = e-127, Method: Composition-based stats. Identities = 109/427 (25%), Positives = 190/427 (44%), Gaps = 19/427 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + L ++ + I GL RVS + LG + + + +AGTNGKG+T SI Sbjct: 1 MSIEQALEWIHSRLKFNIRPGLNRVSALLELLGNPEESLSMIHIAGTNGKGSTVAFTRSI 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTY 123 M AG KV ++SP + + ER+ + Q +P+ I+ + +T Sbjct: 61 FMQAGLKVASFTSPFITTFGERMSINAQPIPDEKLIYYVKMIQPLVEKLDNDAELTGITE 120 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T A F ++D+ ++EVGLGG LD+TN++ V+ +T+I LDH D LG E Sbjct: 121 FEIITAMAFKYFADEKVDLAVIEVGLGGLLDSTNVIRPVVSGITTIGLDHIDILGSTIEE 180 Query: 184 IGREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDH-DWAFSD 240 I +KAGI ++ P +VG E I +VA++ A + + ++ + +H + F Sbjct: 181 IAAQKAGIIKAGIPVVVGNIELKALRVIWEVARKNTARIYQYPYDYRTELKEHEHFDFFA 240 Query: 241 AHGTLENLPLPLVPQPNAATALAALRAS-------GLEVSENAIRDGIASAILPGRFQIV 293 + + +L L+ A A+ + G+ ++E IR GI A P R + + Sbjct: 241 SQEAILDLEKSLIGLHQVENAGMAIELALVYANKVGINLNEEIIRAGIREAFWPARMEKL 300 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV-VDDW 352 E+P ++ D AHN HA L + + ++ + + KDI + L++V Sbjct: 301 GENPLILLDGAHNVHAMNRLLENLGKEFPDKKITIIFSAITTKDIRQMIKMLQTVKNSRL 360 Query: 353 YCAPLEGPRGATAEQLLEHLGN-GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 + P+ + + S A A ++ +L+ GS + + V Sbjct: 361 ILTTFDYPKALDLKDFRYLEDEGVELAPSWELAIVRAQKALNEDELLLITGSLYFSSQVR 420 Query: 412 EVIDARR 418 E + + Sbjct: 421 EFLKKEK 427 >UniRef50_Q5CB75 Folylpolyglutamate synthase/dihydrofolate synthase n=11 Tax=Thermotogaceae RepID=Q5CB75_THESQ Length = 437 Score = 456 bits (1174), Expect = e-127, Method: Composition-based stats. Identities = 128/429 (29%), Positives = 202/429 (47%), Gaps = 29/429 (6%) Query: 8 QAASPLASWLSYLENLHSKT-IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 L YL + + GLER+S++ ++LG V GTNGKG+ Sbjct: 5 DETMAYLEVLKYLYHKRPMGKVKPGLERISMLLSKLGNPHLKYKSIHVGGTNGKGSVTNM 64 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------S 120 + IL++ GY+VG Y SPHL + ER+R+ + + E + ++E ++ S Sbjct: 65 ISHILISQGYRVGSYYSPHLSTFRERIRLNEEYISEEDVVKIYEKMEPILNELDKEEIFS 124 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 ++FE T A F + +D+ +LEVGLGGRLDATN+V + + ++ DH LG Sbjct: 125 PSFFEVVTAMAFLYFAEKNVDIAVLEVGLGGRLDATNVVFPLCSTIVTVDRDHEKTLGYT 184 Query: 181 RESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVT-----D 233 E I EK+GI + P + GE E + DVA++K + + +++ V + Sbjct: 185 IEQIAWEKSGIIKERVPLVTGERKREALKVMEDVARKKSSRMYVIDKDFSVKVKSLKLHE 244 Query: 234 HDWAFSDAHGTLENLPL---PLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRF 290 + + + + T E+L L NA AL L A+GL +SE AIR+G+ +A GRF Sbjct: 245 NRFDYCGEN-TFEDLVLTMNGPHQIENAGVALKTLEATGLPLSEKAIREGLKNAKNLGRF 303 Query: 291 QIVSESP-RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 +I+ + I D AHNPH AE L +K + + VIG+L DK+ L + Sbjct: 304 EILEKDGKTYILDGAHNPHGAESLVRSLKLYFNDKPLNLVIGILDDKNREDILRKYTGIF 363 Query: 350 DDWYCAPLEGPRGATAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 + + PR L + N + + +A + + DTV V GS Sbjct: 364 ERVIVTCVPSPRMKDMNSLVDTAKKFFKNVEVIEDPLEAIE-----SSEGDTV-VTGSLF 417 Query: 406 TVAHVMEVI 414 V +V E + Sbjct: 418 LVGYVREFL 426 >UniRef50_Q5WEQ5 Folylpolyglutamate synthase n=1 Tax=Bacillus clausii KSM-K16 RepID=Q5WEQ5_BACSK Length = 436 Score = 455 bits (1172), Expect = e-126, Method: Composition-based stats. Identities = 106/434 (24%), Positives = 191/434 (44%), Gaps = 22/434 (5%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 + ++ +L I GL+R+ + LG + VAGTNGKG+T L Sbjct: 2 EVKTAEEAVQWIHSLLPFGIKPGLKRMEWMLEALGHPEQRLTAVHVAGTNGKGSTVSFLR 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLT 122 IL A G+ VG ++SP++ +++ER+ V G + + + ++ ++ S T Sbjct: 62 HILTAGGFSVGTFTSPYIEQFSERISVNGVPISDRDLLQAAQRLKPIVEEVAQSDLGSPT 121 Query: 123 YFEYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 FE T + F + A+ D+ ++EVGLGGRLD+TN+V ++++T I DH LG Sbjct: 122 EFEVLTAMMFYHFAEVAKPDICLIEVGLGGRLDSTNVVTPVLSIITMIGHDHMHILGHTL 181 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYS-VTDHDWAF 238 I EKAGI + P I G E + I++ A++ G+ L + + + + + Sbjct: 182 AEIAYEKAGIIKPGIPVISGVEGEEAYTVISETARQIGSPLHQLNETFLVESLQGRTFTY 241 Query: 239 SDAHG-TLENLPLPLVPQPNAATALAALRA-------SGLEVSENAIRDGIASAILPGRF 290 + L A AL+A ++ + A GIA+ PGRF Sbjct: 242 KEEKDEEAVRYHAGLYGSHQHKNAALALKAVSLLSNSLKRQIGKEAKAIGIANTSWPGRF 301 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 +I+ +P ++ D AHN LT ++ + + ++ +KD+ L + Sbjct: 302 EIIQVNPPIVLDGAHNEEGFLALTAALQERFSDKNIHVLLASTTEKDMNVLLKPFATSGL 361 Query: 351 DW--YCAPLEGPRGATAEQLLEHL--GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 + + R A AE L + + +A M + +D ++V GS + Sbjct: 362 EVAFSFTSFDFHRAANAEDLFKQAPVKRKQVAADWRKALKTMMENLGEQDVLVVTGSLYF 421 Query: 407 VAHVMEVIDARRSG 420 ++ V + + + + G Sbjct: 422 ISEVRQSLASYKEG 435 >UniRef50_Q12P54 FolC bifunctional protein n=10 Tax=Shewanella RepID=Q12P54_SHEDO Length = 448 Score = 455 bits (1172), Expect = e-126, Method: Composition-based stats. Identities = 205/425 (48%), Positives = 286/425 (67%), Gaps = 16/425 (3%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNGKGTTC 64 P+ + L WL YL ++H ID+GL RVS VA +L +L AP V TVAGTNGKGT+C Sbjct: 22 RPKQGATLQDWLDYLLSIHPAEIDMGLSRVSQVAKQLQLLDLAPAQVITVAGTNGKGTSC 81 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 LES+L AG +VGVYSSPHL+ Y ERVR+QG + + A A+F+ IE+ARG ISLT+F Sbjct: 82 AMLESVLSFAGKRVGVYSSPHLIHYNERVRIQGVDASDEALIAAFSAIEAARGAISLTFF 141 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 EY TL+ LWLFK A+LDV+ILEVGLGGRLDATN++DAD+ ++TSIALDH ++LG RE++ Sbjct: 142 EYATLAGLWLFKAAKLDVIILEVGLGGRLDATNMIDADICLLTSIALDHQEYLGDTREAV 201 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 GREKAG+FR+ + A++GEP +P T+ D A++ G + R G E++Y + W+F+ + Sbjct: 202 GREKAGVFRANRLAVIGEPALPITVTDYAEQIGTPVCRVGHEFSYEAQGNTWSFNSPNRQ 261 Query: 245 LENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 + L LP++P NAA+ +A L E+S+ + GI A L GRF+ +S SP VI DVA Sbjct: 262 IAALALPVLPLANAASVVALLTQRWPEISDEQLSLGIGQARLAGRFETLSTSPLVIVDVA 321 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNPHAA YL ++ ++ R+LA+ ML DKD+AG L+ L VVD WY A L+ RGA+ Sbjct: 322 HNPHAAAYLAKQL-SVFNGKRILALCAMLKDKDMAGVLSELTDVVDAWYFASLQNERGAS 380 Query: 365 AEQLLEHLGNGKS--------------FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 A QL L ++ F+S++Q W A +A+ +D ++V GSF+TVA + Sbjct: 381 ASQLSAALEQTQAQALEVNLALTQVLEFESLSQGWKALTLEAQEDDIIIVFGSFYTVAGI 440 Query: 411 MEVID 415 +++ Sbjct: 441 KALLE 445 >UniRef50_C9KNY5 Tetrahydrofolate synthase n=2 Tax=Veillonellaceae RepID=C9KNY5_9FIRM Length = 439 Score = 455 bits (1172), Expect = e-126, Method: Composition-based stats. Identities = 120/437 (27%), Positives = 195/437 (44%), Gaps = 25/437 (5%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 + A +SYLE L I LGL R+ + L + + V GTNGKG+ Sbjct: 2 ERRAMNYQEAISYLEGLKIFGIRLGLTRIERLLELLDMPQDRYRTIHVTGTNGKGSVSAM 61 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDIS 120 +E +L +G G YSSPHLV YTER+RV GQ + E I + A G Sbjct: 62 VEGVLRRSGIHTGFYSSPHLVSYTERIRVDGQNISEQDFAEGMTVIRAKIDMMLAEGAEC 121 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 T FE T + F + Q++ ++EVGLGG LD+TN++ +V+V+T++ ++H D LG Sbjct: 122 PTQFEVLTALGFYYFAKCQVEYAVIEVGLGGTLDSTNVITPEVSVITNVTMEHADKLGGT 181 Query: 181 RESIGREKAGIFRSEKPAIVGEP-EMPSTIADVAQEKGALLQRRGVEW-----NYSVTDH 234 +SI KAGI + P + E I VA+EK A + G ++ + Sbjct: 182 LQSIAENKAGIIKEGVPVVTAAKGEPLEVIRAVAEEKNADIFVAGEDFCSQFLSCDGRTQ 241 Query: 235 DWAFSD-----AHGTLENLPLPLVPQPNAATALAALRAS---GLEVSENAIRDGIASAIL 286 F+ H E L + N+A AL +R ++ + + + Sbjct: 242 KLEFTSELLGIDHEPYELHLLGVHQVENSAVALMTIRLLHNIDDRITMKTVTEALRLVSW 301 Query: 287 PGRFQIVS-ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 P RF+ + ++ D AHNP + L + + + ++G+L DKDI L L Sbjct: 302 PARFERLELGQQAIVVDGAHNPAGMKALRESLDEIFPAEERVLLLGILKDKDIDTMLDIL 361 Query: 346 KSVVDDWYCAPLEGPRGATAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVC 401 D + R +A L + + ++F++ +A + A+ A E +++ Sbjct: 362 LRPNDTVVVTVPQSERADSAADLLRRVAPAVQHVEAFENNTEALNRALELANGEKLLVIA 421 Query: 402 GSFHTVAHVMEVIDARR 418 GS + V V +++ R Sbjct: 422 GSLYLVGGVRQMLLKRE 438 >UniRef50_A7VV81 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VV81_9CLOT Length = 432 Score = 454 bits (1169), Expect = e-126, Method: Composition-based stats. Identities = 121/427 (28%), Positives = 199/427 (46%), Gaps = 18/427 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + + +L + GLER+ + R+G + VAGTNGKG+ C L S+ Sbjct: 1 MTYRDAVHKINSLLRFGMKPGLERIQALLDRMGNPQKQLKFVHVAGTNGKGSACALLSSV 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-----LTYFE 125 L AGY+ G+++SP++ + ER ++ G+E+PE + +++ +T FE Sbjct: 61 LREAGYRTGLFTSPYITDFRERFQINGEEIPEETLARILGRLMPMVEEMAERGEVITEFE 120 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESI 184 T A F + + DVV+LEVGLGGR DATN++D AV+ SI+LDHT LG E I Sbjct: 121 LITALAFQWFYEEKCDVVVLEVGLGGRFDATNVIDTPLAAVIMSISLDHTAILGDTVEQI 180 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 EK GI + ++ + VA R + SV + + + Sbjct: 181 AFEKCGIVKEGGDVVLYPDQEEGVYGVVAHAVQNHNGRLVLPSPSSVREVSSSIEGTVAS 240 Query: 245 LEN--LPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 + LP + AL L+ G +S A++ G+A A +P R +++ S Sbjct: 241 YRDEEYQLPFLGAHQLKNAAAAFAALELLKEKGYRISREAMQAGVAKAYIPARMEVLGRS 300 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P VI D AHNP AA L ++ + +++ V+GML DKD +L L S+ A Sbjct: 301 PLVILDGAHNPGAARVLAQALEKYLPHRKIIGVMGMLKDKDSRSSLRSLASLFQALITAS 360 Query: 357 LEGPRGATAEQLL----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 + PR A +L E+ + + +++A A A + +++CGS + + Sbjct: 361 PKNPRALPAAELADRAREYCSQVFAEEDLSKAICLARKLAGEDGAIVICGSLYLAGEIRP 420 Query: 413 VIDARRS 419 ++ + Sbjct: 421 LLLNGPA 427 >UniRef50_C9LMI1 Tetrahydrofolate synthase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMI1_9FIRM Length = 440 Score = 454 bits (1169), Expect = e-126, Method: Composition-based stats. Identities = 127/435 (29%), Positives = 195/435 (44%), Gaps = 29/435 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 +S LE I GLER+ + A LG + A + + GTNGKG+ + S+L Sbjct: 3 YQESISRLEEASVFGIKPGLERMQKILAVLGNPEKACKMIHITGTNGKGSVAAMITSVLE 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEY 126 +VG ++SPHL+ YTER+ + G+++ + + A G+ +LT FE Sbjct: 63 NTNLRVGRFTSPHLIDYTERIYLGGKDISREDFAKAATVVFKAHDELVAAGEEALTEFEL 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T A W F++ + D ++EVG+GGR DATN+V V+V+T++A+DH +LG + I R Sbjct: 123 LTAIAFWYFRENKADYAVMEVGMGGRFDATNVVMPVVSVITNVAMDHMQYLGNTLQEIAR 182 Query: 187 EKAGIFRSEKPAIVGEPE-MPSTIADVAQEKGALLQRRGVEWNYSVTD-------HDWAF 238 EKAGI + P + + A K A + G ++ + Sbjct: 183 EKAGIIKEGIPVVTAAQHVALKELKKDAHNKKARIYFYGRDFEIDTRNKWEQGQVVVVKR 242 Query: 239 SDAHGTLEN--LPLPLVP------QPNAATALAALRASGLEVSENAIRDGIASAILPGRF 290 LE L +P + AA AL L ++EN +R+G+A A GRF Sbjct: 243 KGMPKELEKSMLFVPFIGAHQAVNAAVAAMALTILMKEDGRINENDLREGLARARWQGRF 302 Query: 291 QIVSESP-RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 +I V+ D AHN AE L ++ + R + V L DK + L Sbjct: 303 EIHHAGGKTVVLDGAHNEAGAEALQEALREQYPDKRRIFVFSSLQDKTTETIIQMLVRKG 362 Query: 350 DDWYCAPLEGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 D Y PR T E++ E + K SVA A + A+ +A D VLVCGS Sbjct: 363 DKVYACAAPTPRTRTPEEICEMIDRQKIRAEHKIAGSVADALEKAVKEADENDIVLVCGS 422 Query: 404 FHTVAHVMEVIDARR 418 + + + + + Sbjct: 423 LYILGDAIRWLRKQE 437 >UniRef50_Q2BMN3 Folylpolyglutamate synthase n=1 Tax=Neptuniibacter caesariensis RepID=Q2BMN3_9GAMM Length = 419 Score = 453 bits (1167), Expect = e-126, Method: Composition-based stats. Identities = 178/415 (42%), Positives = 246/415 (59%), Gaps = 11/415 (2%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WLS++E H+ IDLGL+RVS VA L + + V TVAGTNGKG+T L SI + Sbjct: 7 LTQWLSWMEQCHTAEIDLGLDRVSRVADELQLDLSSSTVVTVAGTNGKGSTVSYLSSIYL 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AGY VG Y+SPH +RY ERVR+ G E + +F I+ ARG I LTYFE+GTL+AL Sbjct: 67 QAGYSVGAYTSPHFLRYNERVRLNGLEATDEQLCDAFERIDQARGQIPLTYFEFGTLAAL 126 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +F + D+V+LEVGLGGRLDA NI+DADV+VVT++++DH DWLG DRE IG EK+GIF Sbjct: 127 IIFADTKPDLVLLEVGLGGRLDAVNIIDADVSVVTTVSIDHVDWLGDDREFIGHEKSGIF 186 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS-----DAHGTLEN 247 R++KPAI G+ P ++A A + GA L + ++++ T W + + + + Sbjct: 187 RADKPAICGDLNPPVSVAKYAADIGAELYQADQQFSFEKTKKGWHWKGLNADGSEQIIND 246 Query: 248 LPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDVAHN 306 LPLP +P NA+TA+ + L VS + I+ G+ +A L GR Q + + DVAHN Sbjct: 247 LPLPSLPLQNASTAIQVCQHIPLNVSADQIKTGLQTATLTGRMQKLEVDGVNYWLDVAHN 306 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 P AAE L R+K +P V ++GML DKD + + VVD Y L PRG A Sbjct: 307 PEAAELLAKRIKDMP--KPVTLLLGMLADKDCQQVIDLITPVVDSIYLTDLNVPRGQKAS 364 Query: 367 QLLEHLG---NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 L L + D+V A + AE+ V++ GSF TV+ + + + Sbjct: 365 ALAALLPSGVHALQADTVKSAIEQIKKHTNAEENVIIAGSFFTVSDALSELGKEK 419 >UniRef50_B0VF02 FolC bifunctional protein n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VF02_9BACT Length = 426 Score = 452 bits (1164), Expect = e-125, Method: Composition-based stats. Identities = 132/419 (31%), Positives = 209/419 (49%), Gaps = 18/419 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 +L ++ +S + L L R+ + +G + F + GTNGKG+ C TLE++ Sbjct: 3 YNEFLEHIFKRYSGNVKLELNRMQGLLNDMGNPERKLNGFHIGGTNGKGSVCATLEALCR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 +G + +SPHL+ Y ER R+ G+E +F E+ ++FE T A Sbjct: 63 ESGLNTALNTSPHLINYNERFRINGKEPSFETILNTFLRYENLFDKWEASFFEITTALAF 122 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +F + +DV I+EVGLGGRLDATN+ DVAV+T+I LDH LG E I EKAGI Sbjct: 123 SMFSEHNVDVSIIEVGLGGRLDATNLFIPDVAVITNIGLDHIKTLGGTLEIIAGEKAGII 182 Query: 193 RSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDH-----DWAFSDAHGTL 245 + P ++G+ E S I VA+ K + R +W S+ + ++ +S + Sbjct: 183 KEGIPLVLGDIEESPRSIIEAVAKTKKVPVFRYKRDWQTSIRNDNLTGINFDYSFGNYEF 242 Query: 246 ENLPLPLVPQPNAAT---ALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 NL L+ + A AL A L V+E IR + GR Q++S+ P Sbjct: 243 PNLEANLMGEHQAINIGSALTAFILYAEKKKLPVAEEVIRKALQHISWKGRMQLLSQKPI 302 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 +I D AHN H + L ++ + N +V ++ +L DKD L+ + + Y A + Sbjct: 303 IIIDGAHNVHGVKALMSTLEKIFPNRKVKFMVSILRDKDYKQMLSLICPKAEQIYVARNQ 362 Query: 359 GPRGATAEQ----LLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 R A+ E + E+ K+ +VA+A+ A+ + K +D ++VCGS TV V+E+ Sbjct: 363 SERAASVEDQVAVIEEYNIPYKTAPTVAEAYSLAVKECKEDDILIVCGSLFTVGEVLEI 421 >UniRef50_C6MBR5 FolC bifunctional protein n=1 Tax=Nitrosomonas sp. AL212 RepID=C6MBR5_9PROT Length = 432 Score = 452 bits (1164), Expect = e-125, Method: Composition-based stats. Identities = 172/420 (40%), Positives = 245/420 (58%), Gaps = 16/420 (3%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 WLSY E H +TI+LGL+R++L+ + L + P + V GTNGKG+ C LESIL A Sbjct: 13 DWLSYFEAFHPQTIELGLDRINLIRSELAL-HPQFPIIIVGGTNGKGSVCAMLESILYCA 71 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA--RGDISLTYFEYGTLSAL 132 GY+VG Y+SPHL+ Y ER+R+ + + + +F +I SA DISLTYFE GTL+A+ Sbjct: 72 GYEVGCYTSPHLLHYNERIRISKKNIDDQRLCNAFMQIYSACKVRDISLTYFEVGTLAAM 131 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 + F QA ++ +LEVGLGGRLDA NI DAD +++TS+ LDH D+LG RE IG EKA IF Sbjct: 132 YCFVQAGVNAAVLEVGLGGRLDAVNIFDADCSILTSVDLDHIDYLGDTREKIGFEKAAIF 191 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL 252 R KPAI E ++P ++ A+ A+L R + + + W F +LP P Sbjct: 192 RKNKPAICAEIDLPQSVIQQAENNDAILYRINKHFGFLKQEMHWDFWGPRNKRYSLPFPA 251 Query: 253 V----PQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 + NA+T LAAL L VS + +R G+ A++ GRFQ+VS P +I DVAHN Sbjct: 252 LRGEKQLQNASTCLAALDTLEETLPVSMSNVRQGLIEAVISGRFQVVSTQPFIILDVAHN 311 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 P AA L+ ++A G+ A++ ML DKDI G + LK+ +D W+ + ++ R A A+ Sbjct: 312 PGAAMVLSQNLRATRPTGQTFAIMAMLQDKDIRGVIQALKNDMDYWFVSSVDASRAAAAD 371 Query: 367 QLLEHLGNGKS-------FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 L+ L + F A+ A A D + V GSF+TV V+ ++ +S Sbjct: 372 YLINELYEAEVANDRIRKFSDTISAFVFACEQAGKNDRICVFGSFYTVGDVLRYLNTHQS 431 >UniRef50_Q2LQC5 Folylpolyglutamate synthase / dihydrofolate synthase n=1 Tax=Syntrophus aciditrophicus SB RepID=Q2LQC5_SYNAS Length = 465 Score = 452 bits (1164), Expect = e-125, Method: Composition-based stats. Identities = 116/408 (28%), Positives = 190/408 (46%), Gaps = 14/408 (3%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 L +L+ I LGL+ + + R+ + + GTNGKG+T L IL +GYK Sbjct: 39 QRLLDLNCNIIRLGLDPIRHLLERMENPQLKYPAVLIGGTNGKGSTAAILSCILKESGYK 98 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQ 137 VG+Y+SPHL ER+R+ G + E F I+S+ + LTYFE T SA F Q Sbjct: 99 VGLYTSPHLTSICERIRINGSLISEERMQDCFGMIQSSLEE-PLTYFEVLTASAYLYFYQ 157 Query: 138 AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKP 197 ++D+ +LEVG+GGRLDATN+V V+V++++ L+H ++LG I EKAGI + Sbjct: 158 EKVDIAVLEVGMGGRLDATNVVTPLVSVISNVHLEHQEYLGRHLRDIAAEKAGIIKENSV 217 Query: 198 AIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-WAFSDAHGTLENLPLPLVP 254 + + + +++ ++K A L R G + V +++ L++L L Sbjct: 218 CVTAVTQKAVLDLLSETCRQKEATLYRLGKDIRVRVKGDGTFSYQGIAIKLDDLKCTLSG 277 Query: 255 QPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPH 308 A + G+ V+ A+ G+A A GR +I+ +P V+ D AHNP Sbjct: 278 AHQIKNAALALAAAEVVTTKGIRVNRQAMLSGVACASWDGRLEILQNTPTVLVDGAHNPA 337 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 AA L ++ + L + G L DK+ L L D + R L Sbjct: 338 AANVLCQALRNRNADDHRLLIFGALGDKNYRLMLKKLLPFFDHVIFTKPKTERAVDVADL 397 Query: 369 LEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 + + ++ + +A A+ D + + GS + V + + Sbjct: 398 IRAARHYDRSAEAIEDSCEALQRALCLTGKNDMICITGSLYLVGEIKK 445 >UniRef50_C2E893 Folylpolyglutamate synthase / dihydrofolate synthase n=1 Tax=Lactobacillus ruminis ATCC 25644 RepID=C2E893_9LACO Length = 437 Score = 452 bits (1164), Expect = e-125, Method: Composition-based stats. Identities = 113/434 (26%), Positives = 196/434 (45%), Gaps = 27/434 (6%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 +S++ T D L ++ +A +G + + V GTNGKG+ L Sbjct: 2 TKMSYDEAVSFIHGRRKFTKDPSLVKMRRMAELMGNPQKKLKLIHVTGTNGKGSVTAYLR 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------L 121 +LM+ GY+VG ++SP +VR+ ERV + G+ +P++ I+ I Sbjct: 62 ELLMSHGYRVGTFTSPFIVRFNERVAINGEMIPDNELVEEVERIKPVIERIDDEFDNDGP 121 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 FE T L F + ++D I+EVG+GG D+TNI+D V+V+T++A+DH + LG Sbjct: 122 KEFEVLTAIMLDYFVKMEVDYAIIEVGIGGTYDSTNIIDPIVSVITTVAMDHANILGDTI 181 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS 239 + KAGI + ++P I+G E I A+E+ + + + V++ + + F Sbjct: 182 AKVAENKAGIIKKKRPVIIGKLPKEALEVILSKAKEQDSRIYQPEVDYRARLEEGCDHFW 241 Query: 240 DAHGTLE----------NLPLPLVPQPNAATALAALRAS----GLEVSENAIRDGIASAI 285 E NAA AL A G+++ + + Sbjct: 242 GESFAYEFEEEKWPLQRTGLFGNFQVDNAACALTAFNVLSEIEGIKIDRRKAGEALEKTR 301 Query: 286 LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 PGRF+ + E P ++ D AHNP A E + ++ K ++ ++G+L DK+ + L Sbjct: 302 WPGRFEKIQEDPLIVLDGAHNPSAMEEVEKTLETNFKGKKITVILGILADKNSGEMIEVL 361 Query: 346 KSVVDD-WYCAPLEGPRG-ATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 +GPR A+ ++L E+ D +A +AA+ + D +L GS Sbjct: 362 LKNPKASIILTGFDGPRQVASPKKLHENHPRTIEIDDWKEALEAAL--MQKSDLILASGS 419 Query: 404 FHTVAHVMEVIDAR 417 + ++ V + I R Sbjct: 420 LYFISDVRKYILER 433 >UniRef50_C6P114 FolC bifunctional protein n=1 Tax=Sideroxydans lithotrophicus ES-1 RepID=C6P114_9PROT Length = 456 Score = 451 bits (1162), Expect = e-125, Method: Composition-based stats. Identities = 202/450 (44%), Positives = 250/450 (55%), Gaps = 49/450 (10%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 S LA WLSYLE+LH KTI LGLERV V +L L+PA V V GTNGKG+ C LESI Sbjct: 3 STLADWLSYLESLHPKTIALGLERVEQVRRKL-NLQPAFPVIIVGGTNGKGSVCAMLESI 61 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L AAGYKVG Y+SPHL+ Y ERVR+ Q+ ++ ASFAEIE ARGDISLTYFE+GTL+ Sbjct: 62 LHAAGYKVGCYTSPHLLEYNERVRIAKQQASDAELCASFAEIEQARGDISLTYFEFGTLA 121 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ F Q+DV +LEVGLGGRLDA N+ DADVAVV S+ +DH D+LG RE I EKAG Sbjct: 122 AMQCFISHQVDVAVLEVGLGGRLDAVNVFDADVAVVASVDIDHVDYLGDTREKIAFEKAG 181 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD----------------- 233 IFR + AI + ++P + AQ A L G E+ + + Sbjct: 182 IFRQGRVAICADGDVPQALRQHAQAVAAELWCIGSEFGFQLPSPAGGGEGGGEAHVINVG 241 Query: 234 ------------------HDWAFSDAHGTLENLPLPLV----PQPNAATALAALRAS--G 269 W F GT +LP P + NA+ LA L A Sbjct: 242 QPLSLALSRSREREQKPMGQWNFYSKVGTRSSLPFPALRGAFQLHNASAVLAVLDALKDK 301 Query: 270 LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAV 329 L VS A+R G+ L GRFQ V P++I DVAHNPHAA L + ALP + AV Sbjct: 302 LPVSMEAVRRGLVEVQLAGRFQFVPGLPQLILDVAHNPHAARSLAQNLAALPP-AKTFAV 360 Query: 330 IGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKS------FDSVAQ 383 ML DKD+ G + L +D W A + PRGATA +L++ L + + S+A Sbjct: 361 FAMLKDKDMTGVVEALDGQIDVWLVAGITAPRGATAAELVQVLQDVQVRGEIQPCASIAD 420 Query: 384 AWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 A A A D + GSF+TVA VM V Sbjct: 421 AMHEASNRAGENDRIAAFGSFYTVAEVMRV 450 >UniRef50_D1BNH4 FolC bifunctional protein n=3 Tax=Veillonella RepID=D1BNH4_VEIPT Length = 435 Score = 450 bits (1159), Expect = e-125, Method: Composition-based stats. Identities = 124/429 (28%), Positives = 188/429 (43%), Gaps = 25/429 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L+YLE S I GLER++ + LG + + V GTNGKG+ + Sbjct: 1 MTYQEALAYLEQASSFGIKPGLERITALMDVLGNPQEDYKIVHVTGTNGKGSVTSYISYA 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYF 124 L +G +VG ++SPHL YTER+++ + E A + ++ A I + T F Sbjct: 61 LFTSGLRVGRFTSPHLQSYTERIQINDGNITEEAFGELISRVKGAVDTIVSNGIEAPTQF 120 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T +A FK+ +D ++EVGLGG LD+TNIV V+V+T++ +DH + G E I Sbjct: 121 EMLTAAAFLFFKEQGVDYAVVEVGLGGLLDSTNIVTPKVSVITNVTIDHQAYCGDTVEEI 180 Query: 185 GREKAGIFRSEKPAIVGEPEMP-STIADVAQEKGALLQRRGVEW-----NYSVTDHDWAF 238 R KAGI + + P + + P + I DVA+++ A L ++ + Sbjct: 181 ARHKAGIIKPKVPVVTAAQDTPLNIIEDVAKKQHAKLYVFNKDFGIDSRSAVTGGQMITV 240 Query: 239 SDAHGTLENLPLPLVPQP---NAATALAALRAS---GLEVSENAIRDGIASAILPGRFQI 292 S L + N A AL A+R +SE +R+G A GRF++ Sbjct: 241 STNDAAPAMLFTTMAGIHQSVNLACALMAVRLLMKEDTNISEETMREGFARTTWAGRFEV 300 Query: 293 VSE-SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 IFD AHN AE L K+ V+ +L DKD + + V D Sbjct: 301 KRGLDRTFIFDGAHNAAGAESFAMTYDELFKDSPKTIVMAILKDKDQEAIIREVVKVGDT 360 Query: 352 WYCAPLEGPRGATAEQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 P R E L+E + ++ DS+ A A K D + VCGS + Sbjct: 361 VLVVPAPTDRTEVPETLVEMIRRTVPKATAQTADSIEAALALAYKHTKTGDIIAVCGSLY 420 Query: 406 TVAHVMEVI 414 + + Sbjct: 421 ILGDARQWF 429 >UniRef50_A5N275 FolC n=22 Tax=Clostridium RepID=A5N275_CLOK5 Length = 450 Score = 450 bits (1159), Expect = e-125, Method: Composition-based stats. Identities = 109/442 (24%), Positives = 200/442 (45%), Gaps = 37/442 (8%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L Y+ N+ ++LGLER + LG VAGTNGKG+ + +LM Sbjct: 3 YKDTLQYINNIAKFGVNLGLERTEKILELLGNPHKKIKAVHVAGTNGKGSITVMISRVLM 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 AG+KVG+Y+SP+L ++ ER+++ G+ + + ++ A + + T FE Sbjct: 63 EAGFKVGMYTSPYLEKFEERIQINGKNISHDDLSRVVTKVSKAVDKVLQLGYDNPTEFEV 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDA---------DVAVVTSIALDHTDWL 177 T + + F + ++++ ++EVGLGGR D+TN++ + +V+ SI+ DH + L Sbjct: 123 ITCAMFYYFWEKKVEIAVIEVGLGGRFDSTNVMVSFAKECEGGVMASVIASISYDHMNIL 182 Query: 178 GPDRESIGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHD 235 G E I EKAGI + P I+ + I V +EKG+ L + V + + + Sbjct: 183 GDTLEKIAYEKAGIIKKGIPVILYPQSESVEKVIEKVCEEKGSELLKVPVNSSNLIGGNK 242 Query: 236 WAFSDAHGTLE----------NLPLPLVPQPNAATALAALRAS------GLEVSENAIRD 279 + ++ L L+ + AAL + V ++ I Sbjct: 243 IDSGSREYVQQVKIATKEADYDIKLSLLGKHQLLNCAAALFTLEQLSRYDILVDKSVISR 302 Query: 280 GIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIA 339 + + GR +++ +P V+ D AHN L + + ++ ++G+L DK++ Sbjct: 303 ALGNVSWKGRLEVMGRNPLVVIDGAHNIQGISMLKENICRYFQYNDMILILGILADKEVE 362 Query: 340 GTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAE 395 + + + + RG A +L +G N + F+ +A+ A++ E Sbjct: 363 KMVKTIVPLAKRVMAVTPKDKRGQIAGRLKTIIGKYNSNCEDFNDYEKAYRKALSYCSKE 422 Query: 396 DTVLVCGSFHTVAHVMEVIDAR 417 D +LVCGS + V + ++I Sbjct: 423 DLILVCGSLYMVGDMRKIIKRH 444 >UniRef50_B5YJI6 Folylpolyglutamate synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YJI6_THEYD Length = 438 Score = 450 bits (1159), Expect = e-125, Method: Composition-based stats. Identities = 127/425 (29%), Positives = 214/425 (50%), Gaps = 23/425 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 ++ L + I LGL RV V +LG + +AGTNGKG+ + + ++ Sbjct: 7 YKELINELYKKRTNGIKLGLNRVISVLEKLGNPHHSFKSIHIAGTNGKGSVSKIIYCLIR 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 A G VG+++SPHL R+TER+ V E+ E +I+ + LT+FEY T+ AL Sbjct: 67 AQGLSVGLFTSPHLTRFTERIIVNDIEISEEEVEHLIEKIKPFSDE--LTFFEYVTVMAL 124 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 FK+ ++ ++E G+GGRLDATN+V+ ++V+T+I LDH ++LG D SI +EKAGI Sbjct: 125 QYFKEKGIEYAVIETGMGGRLDATNVVNPLISVITNIGLDHQEFLGADLASIAKEKAGII 184 Query: 193 RSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTD----------HDWAFSD 240 ++ P + E+ I A+E + L ++ + + ++F Sbjct: 185 KNGIPVVSSSQKKEVEKVIIKKAEEMESPLFIYDRDFIGVLKSMSLEGIVFDFYPFSFQP 244 Query: 241 AHGTLE-NLPLPL---VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 + +L+ NL LPL N + AL A +ENAI++G+ + +PGR +I+ + Sbjct: 245 STSSLQSNLFLPLTGFHQLENVSVALKAFINIYPMYNENAIKEGLKNVKIPGRLEIIYDK 304 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P +FD+AHNP AAE L +K L + + + V M+ DK++ + ++ Sbjct: 305 PLAVFDIAHNPDAAEVLIKSLKTL-TDKKPVVVFAMMRDKNVNEFIKCFENYAYKMIFTV 363 Query: 357 LEGPRGATAEQLLEHLGNGKS--FDSVAQAWDAAMADAKAEDTV--LVCGSFHTVAHVME 412 R T ++LL+ L + K +A+ A++ K + L GS + V + E Sbjct: 364 PNYERALTYKELLKRLNDKKIDFVPEPLEAFRNAISLCKNNSDIYVLCTGSAYLVGEIKE 423 Query: 413 VIDAR 417 + + Sbjct: 424 RLGEK 428 >UniRef50_Q3A6L0 Folylpolyglutamate synthetase; dihydrofolate synthetase n=1 Tax=Pelobacter carbinolicus DSM 2380 RepID=Q3A6L0_PELCD Length = 422 Score = 450 bits (1158), Expect = e-125, Method: Composition-based stats. Identities = 137/418 (32%), Positives = 206/418 (49%), Gaps = 13/418 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L+YL L I LGL + + ARL + A + VAGTNGKG+ IL Sbjct: 3 YQQSLAYLYGLQRFGIKLGLTNIQTLLARLDHPERAMRIVHVAGTNGKGSVSAATALILQ 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AGY+ G+Y+SPHL +TER+R+ G ++ E + E+ + G + +T+FE+ T AL Sbjct: 63 TAGYRTGLYTSPHLHSFTERIRIDGVQVSEPDMVSLVDEVRAVVGSLPVTFFEFTTAMAL 122 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F+ D +LEVG+GGRLDATN V+++++VVT + DH + LG D +I EKAGI Sbjct: 123 VYFRNRHTDFAVLEVGMGGRLDATNAVESEISVVTPVCCDHAEHLGADLATIAGEKAGII 182 Query: 193 RSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 + + P ++ E P+ + A E A + ++ D + F TL+ L Sbjct: 183 KRQVPVVIAEQHPDAQRVLLTKAAEMLAPVCLWDRDFRIIDHDTHFDFFAPSLTLKGLRP 242 Query: 251 PL---VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 L + N A ALAA LR G+ +SE A+R G+ PGR + + R++ D A Sbjct: 243 GLAGAHQRQNLAVALAACMSLRNRGVALSEEALRYGVEKVQWPGRLEWWRQQRRILLDGA 302 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HN A L + +L +V V+G+ + I L L Y +G Sbjct: 303 HNHGGAVVLARYLASLD-GKKVRWVVGIKGQRCIDDILTPLLPHTAHLYATLPPVDQGIE 361 Query: 365 AEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 ++L+ K++ + A A AA+AD +D VLV GS VA V + + R Sbjct: 362 PDKLVRAARAAGVLAKAYATPADAMTAALADQGEDDVVLVAGSLFLVAAVRDYLMDRE 419 >UniRef50_Q38XD0 Putative polylpolyglutamate synthase n=1 Tax=Lactobacillus sakei subsp. sakei 23K RepID=Q38XD0_LACSS Length = 434 Score = 449 bits (1156), Expect = e-125, Method: Composition-based stats. Identities = 112/430 (26%), Positives = 190/430 (44%), Gaps = 23/430 (5%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + + L+Y+ + + L R++ + A LG V GTNGKG+ + S Sbjct: 3 VTDYETALAYIHSRPRLHKEANLNRMTQLLAALGNPHQGQQFIHVTGTNGKGSVVNMVSS 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LT 122 +L+ G KVG Y+SP + R+ ER+ + Q + + A ++ + +T Sbjct: 63 LLVELGLKVGRYTSPFITRFNERIAIDQQPIADDDLVAVTQHVQQTIETVQQADTTFEVT 122 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 FE T FKQ +D+ ++EVG+GG D+TN++ ++V+TS+ LDH LG Sbjct: 123 EFELITAIMFTYFKQQAVDIAVIEVGIGGLYDSTNVLTPLISVITSVGLDHQALLGDTLA 182 Query: 183 SIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT------DH 234 +I +KAGI +++ P ++G E + I + A+ + L GV+++ + Sbjct: 183 AIATQKAGIIKAQHPVVIGKLPAEAQTVIVETAKRLASPLAISGVDFSTTAVKTLPTWGQ 242 Query: 235 DWAFSDAHGTLENLPLPLVPQPNAATALAALRAS-------GLEVSENAIRDGIASAILP 287 F + TL+ L +PL+ A AL + ++ G+A P Sbjct: 243 QLNFQNQTVTLKQLQIPLMGDYQIENAAVALETFCQYLALTQQPLDIKTLKRGLAHVSWP 302 Query: 288 GRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS 347 GRF+ V++ P +I D AHNP E L K K+ + + G L DK +AG L L Sbjct: 303 GRFEKVNDEPLIILDGAHNPAGVEQLVKTAKHQFKHQDIYILFGALGDKSLAGMLPELNQ 362 Query: 348 VVDDWYCAP-LEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 + + PR AT Q A +++ A+D +LV GS + Sbjct: 363 LATHLVLTTVPDNPRAATQAQYAAVDNTIPFEADWPVALTTMVSELSADDVLLVTGSLYL 422 Query: 407 VAHVMEVIDA 416 ++ + Sbjct: 423 ISTIRSYFKG 432 >UniRef50_A5IBI5 FolC bifunctional protein n=4 Tax=Legionella pneumophila RepID=A5IBI5_LEGPC Length = 428 Score = 449 bits (1155), Expect = e-124, Method: Composition-based stats. Identities = 162/426 (38%), Positives = 241/426 (56%), Gaps = 11/426 (2%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 TP + L WL++LE +++ I LGL RV VA +L + +P V TVAGTNGKG+T Sbjct: 2 HTPWSEWDLNHWLTHLETRNTQEIQLGLTRVLTVAQKLNLQRPNCKVITVAGTNGKGSTV 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 LE+I +G++VG Y+SPHL+ + ER+R+ + + +F+ IE AR +LTYF Sbjct: 62 TALETIYHQSGFRVGTYTSPHLLVFNERIRINLTPIQDKDLCKAFSVIEEARYPTNLTYF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E TL+ALW FKQ LD++ILEVGLGGRLDATNIVD D+A++T+I DH ++LG E I Sbjct: 122 EMATLAALWYFKQHDLDLIILEVGLGGRLDATNIVDTDLAIITTIDFDHQNFLGDTLELI 181 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 G EKAGI R KP I + P ++ +VA + GA G ++ Y W + Sbjct: 182 GYEKAGILRKNKPFIYADLSPPKSVVEVALQLGASSYLYGKDYFYQEEADHWEVTCQGKP 241 Query: 245 LENLPLPLVPQPNAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 E L P + +AA A+ A L + L VS ++ + +PGR Q+ +++D Sbjct: 242 FEQLTRPKIQLRSAAAAVMACHLMQNDLPVSYKNLKKAMELIYIPGRLQLQKGKTDILYD 301 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 V+HNP + L +K + G++ AV L DKD+ G + L+ V+ WY A L R Sbjct: 302 VSHNPQSVRLLADTIKKINVKGQIHAVFSALKDKDLYGLIMPLRDCVNRWYPAQLHNKRA 361 Query: 363 ATAEQLLEHLGNGKSF-----DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM----EV 413 A+ E+LL + F + A++ A+ A +D ++V GSF TV+HVM + Sbjct: 362 ASQEELLSVFREAEIFLDVCYNDPFTAFEMALKQASDDDLIIVYGSFFTVSHVMAAQHNL 421 Query: 414 IDARRS 419 ++ + + Sbjct: 422 LEQKEN 427 >UniRef50_C9RB31 FolC bifunctional protein n=1 Tax=Ammonifex degensii KC4 RepID=C9RB31_AMMDK Length = 426 Score = 448 bits (1154), Expect = e-124, Method: Composition-based stats. Identities = 136/419 (32%), Positives = 202/419 (48%), Gaps = 21/419 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + L+Y++ + + I GLER+ + RLG V GTNGKG+ L SIL Sbjct: 1 MREALAYIQQVAAVGIKPGLERIEALLERLGNPHRRLRFLHVGGTNGKGSVTAFLSSILR 60 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR-----GDISLTYFEYG 127 AAGY+VG ++SPHL Y ER R+ G+ + E E+ I LT FE Sbjct: 61 AAGYRVGTFTSPHLRSYLERFRLNGRPIREREFVWLVNELYPHLEALRQEGIRLTEFEIH 120 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T A LF +A+++V ++EVGLGGR DATN+V ++AV+T++A+DHTD+LG D SI RE Sbjct: 121 TALAFLLFARARVEVAVVEVGLGGRWDATNVVLPELAVITNVAVDHTDYLGSDITSIARE 180 Query: 188 KAGIFRSEKPAIVGEP-EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWA-----FSDA 241 KAGI ++ P + G E + +VA+EKGA L +G ++++ +D Sbjct: 181 KAGIIKAGVPVVTGATGEALRVVEEVAREKGAPLYVQGRDFSFREKANDLTGQVIEVEGW 240 Query: 242 HGTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSE 295 G L L L+ + + A L G ++ + AI+ G+ PGR +IV Sbjct: 241 WGKTPPLRLNLLGRHQQSNAALAVAAARLLEERGWQIDKGAIKVGLYRTRWPGRLEIVFS 300 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 P +I D AHNP L + GR L V+GM DK + + Sbjct: 301 QPTLILDGAHNPAGTAALREALDYYFPRGRRLLVLGMCDDKAREEMVKIIVPGASLVVVT 360 Query: 356 PLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 GPR ++ + + +A A+ A+ ED V+V GS + V + Sbjct: 361 RPPGPRSEDWRRVADWARSLCPQVYLVEEPQEALGQALRQARPEDLVVVTGSLYLVGAL 419 >UniRef50_Q15VG0 FolC bifunctional protein n=1 Tax=Pseudoalteromonas atlantica T6c RepID=Q15VG0_PSEA6 Length = 426 Score = 447 bits (1152), Expect = e-124, Method: Composition-based stats. Identities = 179/421 (42%), Positives = 254/421 (60%), Gaps = 4/421 (0%) Query: 2 IIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 I+ + A L WL +L LH K I++GLERV+ V +L + V TVAGTNGKG Sbjct: 6 SIQASSFEAWSLNEWLDHLSALHPKNIEMGLERVNKVFEQLNISFSKQTVVTVAGTNGKG 65 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL 121 TTC LE +AAG +VGVYSSPHL++YTERVR+ G + E AH +F +E ARGDI L Sbjct: 66 TTCAFLEQACLAAGKRVGVYSSPHLIQYTERVRINGIDGSEQAHCRAFQAVERARGDIPL 125 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 TYFE+GTL+ L L A +D+ +LEVGLGGRLDA N+V D+AV+TSI LDH D+LG + Sbjct: 126 TYFEFGTLAGLKLVHDANVDIALLEVGLGGRLDAVNVVSPDIAVITSIDLDHQDFLGDTK 185 Query: 182 ESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 E + EKAGI R P +VGEP + D + AL + V+++Y + D +S+ Sbjct: 186 ELVAAEKAGIMRDNIPVVVGEPVKYQALLDAVSQHSALASWQHVDFDYQLADDYMVWSNH 245 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 + LP+P +P N +T L ++ L++SE + + I LPGR Q + SP ++ Sbjct: 246 QLSYAQLPIPHIPAQNVSTGLQVIQLLKLDLSEGDLANVITDTRLPGRCQYIGYSPAIMV 305 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 DVAHNPHA YL +++ L + R+ V+GML DKDI +LA ++ W L+ PR Sbjct: 306 DVAHNPHATGYLLSQIRKLDYD-RLYLVVGMLKDKDIRSSLADFSNLNAHWMLGGLDVPR 364 Query: 362 GATAEQLLEHL---GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 GA A + L F +V QA++ A A A+ +D ++V GSF TV+ ++++ + Sbjct: 365 GAAAADIKSVLDEQQKVLEFSTVCQAFEKAKALAQEQDLIVVFGSFFTVSDILKLSNKGN 424 Query: 419 S 419 + Sbjct: 425 N 425 >UniRef50_A9KNK7 FolC bifunctional protein n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KNK7_CLOPH Length = 424 Score = 446 bits (1149), Expect = e-124, Method: Composition-based stats. Identities = 120/419 (28%), Positives = 197/419 (47%), Gaps = 17/419 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + YL + T +L L+ ++ + + + VAGTNGKG+TC+ L SIL Sbjct: 3 YQEAIKYLRSYKRNTGELSLKNLNKLLDYMDHPEKKLKFIHVAGTNGKGSTCKMLSSILR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES----ARGDISLTYFEYGT 128 AG KVG+++SP L E++++ G+ + +++ D T FE T Sbjct: 63 CAGLKVGLFTSPFLETENEQIQINGEVISNEDFAKVCKKVKDFTTYLMLDEIPTEFELTT 122 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGRE 187 A F + D+V+LEVGLGG LDATN+++ V+V+T+I +DH D+LG + I + Sbjct: 123 AMAFQYFYDTKCDLVVLEVGLGGELDATNVIETPLVSVLTNIGIDHVDYLGTTLKEIACK 182 Query: 188 KAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 KAGI + + E E+ I +E+ L ++ ++ Sbjct: 183 KAGIIKENGIVVSYEQEKEVEEVIKLTCEERHNKLVFAEFSELKLHQENLSRQKFSYKQN 242 Query: 246 ENLPLPLVPQP---NAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 NL L L+ + NAA AL L+ G ++SENAI +G+ PGRF+++ + P V Sbjct: 243 TNLSLSLIGEHQRKNAAVALEVIAQLQTLGYKISENAISEGMNYVTWPGRFEVLCKQPLV 302 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 I D HN E + +K + + ++G+L DKD G + +L + + Sbjct: 303 ILDGGHNVQCVEAFSEVLKQFIPGKKAIVILGVLADKDYKGMIPYLVPFTKRFIAVTPKN 362 Query: 360 PRGATAEQLLEHLGNGKSF----DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 R +EQL E L + + AA+ DA+ +D + V GS + A + + Sbjct: 363 TRALPSEQLAEELSKHHPLVSHNATPVEGIMAALRDAREDDIICVIGSLYMAAEIRDCF 421 >UniRef50_C6D869 FolC bifunctional protein n=3 Tax=Bacillales RepID=C6D869_PAESJ Length = 458 Score = 446 bits (1149), Expect = e-124, Method: Composition-based stats. Identities = 118/435 (27%), Positives = 198/435 (45%), Gaps = 30/435 (6%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + ++ L I GL+R+ + RL +AGTNGKG+TC L S Sbjct: 14 LRSYKEAVDWINGLIPFGIRPGLDRIEQLLERLNNPHRRLKFIHIAGTNGKGSTCAYLTS 73 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTY 123 +LM GY VG ++SP++ ++T R + GQ++ E ++S ++ S T Sbjct: 74 VLMKCGYDVGTFTSPYITKFTNRFQYNGQDIDEETLLRLSNVLKSHVEELAETEFGSPTM 133 Query: 124 FEYGTLSALWLFKQAQ-LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 FE T A+ + D V+ E GLGGR+D TNIV ++V+T++ DH D LG E Sbjct: 134 FEVSTALAILFYATVTYPDYVVWETGLGGRMDVTNIVTPIISVITNVGHDHMDRLGDTLE 193 Query: 183 SIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY-----SVTDHD 235 ++ EKAGI ++ P + +PE+ + A EK + L G ++N + Sbjct: 194 AVAFEKAGIIKAGVPVVSAVDQPEVVEVVKRTAAEKKSTLYLLGDQFNIKELSSEEDEQT 253 Query: 236 WAFSDAHGTLENLPL---PLVPQPNAATALAALRASG----LEVSENAIRDGIASAILPG 288 + F +++ L + + NAA A+ L L V ++A+ DG+ A PG Sbjct: 254 FRFEGMFRSIDPLTITLNGAHQRTNAAVAVMTLEVLRQYYALIVEDDALADGLREAKWPG 313 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 R ++VS SPR++ D AHNP AE L +++ + R+ ++ M+ +K+ L + + Sbjct: 314 RLEMVSRSPRILIDGAHNPEGAESLVQALRSTYRYDRLHVMMAMVENKNHRDVLKHILPI 373 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLGNGKSFDS---------VAQAWDAAMADAKAEDTVL 399 VD + AE L + + + K +S + D + Sbjct: 374 VDTLIVTEPDFRSKLDAELLADLVRDVKPAESSFELIVEKDWREGLRKLQQLTGETDLGV 433 Query: 400 VCGSFHTVAHVMEVI 414 V G+ + + V I Sbjct: 434 VTGTLYLIGDVRSRI 448 >UniRef50_Q01UR3 FolC bifunctional protein n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q01UR3_SOLUE Length = 422 Score = 446 bits (1148), Expect = e-124, Method: Composition-based stats. Identities = 133/421 (31%), Positives = 191/421 (45%), Gaps = 22/421 (5%) Query: 13 LASWLSYLENLHS--KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + +L L + KT LGLER++ V LG + VAGTNGKG+TC +ES Sbjct: 3 YPDSVQFLYALGNEVKTAKLGLERIARVLEALGNPHRRTRIVHVAGTNGKGSTCAMIESG 62 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--------DISLT 122 L A+G G+++SPHL TER+R+ G + +A+F + +A D+ T Sbjct: 63 LRASGRSTGLFTSPHLAEPTERIRINGVPVSAERFSAAFDRVHAAVEQLLAVNAIDLHTT 122 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE T A +F + +D+V+LEVGLGGRLDATN+V ++ V+T + DH +LG + Sbjct: 123 YFETVTAMAFLIFAEEAVDIVVLEVGLGGRLDATNVVLPELCVITPVDFDHEAFLGRSLQ 182 Query: 183 SIGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRR----GVEWNYSVTDHDW 236 I EKAGI ++ PA+ E + + A + + R + + Sbjct: 183 EIAGEKAGILKAGVPAVFARQRAEASAVLDQRAAQLSIPIARTVAWPVDDLVLDSRGSRF 242 Query: 237 AFSDAHGTLENLPL-PLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSE 295 S PL NAATA AL G VS+++I GIA PGR + VSE Sbjct: 243 LLSGERDLHIACPLAGEHQVENAATAAIALTRLG--VSDHSIETGIAQTRWPGRLERVSE 300 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 P +I D AHNP A L ++ RV + G + DK I L + Sbjct: 301 HPEIILDGAHNPAGARALAAYIERFYAGRRVRLIYGAMRDKAIDEIAGILFPLAHQVILT 360 Query: 356 PLEGPRGATAEQLLEHL--GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 R E + E + + +AQA A D V + GS VA + Sbjct: 361 APRQARALAPEAIREIADHPDVQVAPDLAQAIALLCDAAS-NDAVFITGSLFLVAEARAL 419 Query: 414 I 414 + Sbjct: 420 L 420 >UniRef50_C2ETR7 Tetrahydrofolate synthase n=3 Tax=Lactobacillus RepID=C2ETR7_9LACO Length = 441 Score = 445 bits (1146), Expect = e-123, Method: Composition-based stats. Identities = 104/437 (23%), Positives = 182/437 (41%), Gaps = 29/437 (6%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + A L+++ L+R+ L RLG + + GTNGKG+T L Sbjct: 5 EMIESYAEALNFIHGRTKFKKIPTLDRMRLFLDRLGNPQKGLKYVHITGTNGKGSTVAML 64 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------- 120 S+LM AG VG ++SP + R+ ER+ + + + + T ++E + Sbjct: 65 RSMLMKAGLNVGSFTSPFITRFNERIALNAEPISDEDLTRLARKVEPVVQQLDQELPTGG 124 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 T FE T F + Q D+V+LEVG+GG D+TN++ V+V+T+++ DH +LG Sbjct: 125 PTEFEIDTAIMFCYFAEKQPDLVLLEVGIGGLYDSTNVITPLVSVITTVSWDHMKYLGDT 184 Query: 181 RESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH---- 234 I +KAGI + P ++G I A EK A + G +++ + Sbjct: 185 LAKIAHQKAGIIKKGVPVVIGQLPSSARQVIMREANEKSAKVYELGKDFSAQKINRNAIK 244 Query: 235 -DWAFSDAHGTLENLPLPL---VPQPNAATALA----ALRASGLEVSENAIRDGIASAIL 286 + + L L NAA A+ L G+ V ++ G+ Sbjct: 245 AEIVYDGDQLHHFRSNLGLAGDYQVENAAIAITTVQIVLTKLGIPVITGDLKKGLEMTRW 304 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 PGR + + P V+ D AHN + L ++ + V ++ +L DK L L Sbjct: 305 PGRMETIISEPLVLLDGAHNLPGMQALVKTIRDDFSDREVYVLVAILADKQYELMLGELA 364 Query: 347 SVVD-DWYCAPLEGP-RGATAEQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTV 398 S+ + GP + L +G + ++ + + A+D + Sbjct: 365 SLGNVHLMVTNFAGPGPKRPSADLATTIGEFKTKYPIQVAENWQTGFVKLSQELAADDVM 424 Query: 399 LVCGSFHTVAHVMEVID 415 ++ GS + V+ V + + Sbjct: 425 IITGSLYFVSEVRKNLK 441 >UniRef50_A6VWY8 FolC bifunctional protein n=2 Tax=Marinomonas RepID=A6VWY8_MARMS Length = 418 Score = 445 bits (1146), Expect = e-123, Method: Composition-based stats. Identities = 192/414 (46%), Positives = 253/414 (61%), Gaps = 11/414 (2%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 A + LASWLSY+E+ H I+LGLER S V ARL + +P V TVAGTNGKG+TC L Sbjct: 2 AHTSLASWLSYIESQHPSEIELGLERGSKVLARLNLSRPKHKVITVAGTNGKGSTCAMLT 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 L A Y VG Y+SPH + + ER+ + + +F +E AR ISLTYFE+ T Sbjct: 62 QYLCAQNYSVGTYTSPHFIAFNERIALNDSPCDDEVLCRAFEVVEEAREGISLTYFEFST 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+ALW+F Q+ LD +LEVGLGGRLD+ N++D DVAVVTSI+LDH DWLG + + I REK Sbjct: 122 LAALWIFDQSNLDYWVLEVGLGGRLDSVNMMDTDVAVVTSISLDHIDWLGDNLDVIAREK 181 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 AGI R +K I G PSTIA A E GA L+++GV++++ + W++S E L Sbjct: 182 AGIARKDKLLISGVVNPPSTIASTALEVGAHLRQKGVDFHFELDGSTWSWSGDGVQFEKL 241 Query: 249 PLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPH 308 P+P +P NAAT +A L G + + SA L GRFQ V+ SP V DVAHNP Sbjct: 242 PIPALPLQNAATVIAVLVYMGFSPAYADLVTLFDSAQLMGRFQKVATSPDVYIDVAHNPE 301 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 AA L R+ LP + +AV GML DKDIA + L DW+C L GPRGA A +L Sbjct: 302 AAIELAQRISNLPI--QPVAVCGMLKDKDIASVMEHLAGSFSDWFCCDLAGPRGAKASEL 359 Query: 369 LEH--------LGNGKSFDSVAQAWDAAMADAKAEDT-VLVCGSFHTVAHVMEV 413 ++H N K+F SV A+ +A+ A+ E V+V GSF TV++ + + Sbjct: 360 IKHIVHSSPSLALNAKAFQSVGDAFSSALVKAQDEQRSVIVFGSFVTVSNYLAL 413 >UniRef50_Q3JCB5 Folylpolyglutamate synthetase n=3 Tax=Gammaproteobacteria RepID=Q3JCB5_NITOC Length = 432 Score = 445 bits (1146), Expect = e-123, Method: Composition-based stats. Identities = 190/412 (46%), Positives = 264/412 (64%), Gaps = 8/412 (1%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 S L+ WL + E H +D L R S V R+ + P + T+AGTNGKG+T LE+ Sbjct: 4 FSRLSDWLRWQETAHWPRVDPSLIRASAVLQRMVLSTPPFPIVTIAGTNGKGSTVALLEA 63 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 IL+AAGY+VG Y+SPHL+RY ER+++QG+ + + SFA I++AR +ISLTYFE+GTL Sbjct: 64 ILLAAGYRVGSYTSPHLLRYNERIKIQGEAVSDDIICQSFARIDAARHEISLTYFEFGTL 123 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +A+ +F QA LD+ +LEVGLGGRLDA N +DADVAV+T++ +DH ++LGPDRESIG EKA Sbjct: 124 AAIDIFHQAGLDIALLEVGLGGRLDAVNALDADVAVITTVDIDHINFLGPDRESIGFEKA 183 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 GIFRS +PAI G+PE P ++ A+E L R G +++Y + W++ +LP Sbjct: 184 GIFRSHRPAICGDPEPPESVLAHAKESSVPLYRIGRDFHYQMAGEGWSWWSNGSHYADLP 243 Query: 250 LPLV----PQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 P + N A AL AL+ A+ L VSE AIRDG+++ LPGRFQ + IFDV Sbjct: 244 HPALQGACQYQNGAAALMALKLMAARLPVSETAIRDGLSAVRLPGRFQCLPGEMERIFDV 303 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 AHN A +L + P GR AV+GML DKD+AG ++ L++ + W+ L RG Sbjct: 304 AHNLQGARWLARSLTDRPCGGRTYAVLGMLADKDVAGVVSVLENAIHGWFVGGLAVDRGL 363 Query: 364 TAEQLLEHLGNGK--SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 + + L E +G+ + SVA+A+ AA+ A+ D VL GSFHTV VM + Sbjct: 364 SGQALAERMGHLTPAIYQSVAEAYRAALEAAQPGDRVLAFGSFHTVEAVMRL 415 >UniRef50_A5ZW55 Putative uncharacterized protein n=1 Tax=Ruminococcus obeum ATCC 29174 RepID=A5ZW55_9FIRM Length = 433 Score = 445 bits (1145), Expect = e-123, Method: Composition-based stats. Identities = 118/427 (27%), Positives = 179/427 (41%), Gaps = 27/427 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 ++Y+E T LE RLG + V VAGTNGKG+TC L S+ Sbjct: 3 YEEAVAYIEETPKFTTKNKLEHTKECLRRLGNPQKQFQVVHVAGTNGKGSTCAFLTSVFR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEY 126 AGY G+++SPHLV ER ++ + + +F +++ A G TYFE+ Sbjct: 63 EAGYSCGLFTSPHLVVINERFQINEKNIDNDTFLRAFEKVKKLADELVAEGSYHPTYFEF 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIG 185 L + +F A +D VILE GLGGRLDAT V + V+TSI+ DH +LG E+I Sbjct: 123 LFLMGMVIFADANVDYVILETGLGGRLDATTAVEEPSACVITSISFDHMQYLGNTIEAIA 182 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVT----DHDWAFS 239 EKA I P I P I AQE G+ E + D+++ Sbjct: 183 GEKAEIIVPGVPVIYDGNNPAAAGVIRARAQELGSPYFEVKREDTKIIRNTRAGIDFSYE 242 Query: 240 DAHGTLENLPLPL---VPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVS 294 + + LP N++ AL + +++ A+R G+ GR + V Sbjct: 243 NEYYGNTVFTLPFIAEYQVMNSSLALKTIEVLKDQVKIPVEAVRKGLLETRWQGRMETVL 302 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS--VVDDW 352 P VI D AHN E K+ + + + DKD + + Sbjct: 303 --PGVIVDGAHNEDGVEKFVETAVHFQKDYPLTLLFSAVDDKDYTDMIRTILGKISFHHV 360 Query: 353 YCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 + G R AE+L E ++ + V +A+ A+A + + GS + V Sbjct: 361 IVTQVGGYRKVPAEKLAEIFREKGCPTAEACEDVEEAFKKALAAKGEDGMLFCVGSLYLV 420 Query: 408 AHVMEVI 414 + +I Sbjct: 421 GEIKTLI 427 >UniRef50_A2SKX9 Cytoplasmic peptidoglycan synthetase, C-terminal domain n=4 Tax=Betaproteobacteria RepID=A2SKX9_METPP Length = 448 Score = 444 bits (1144), Expect = e-123, Method: Composition-based stats. Identities = 199/433 (45%), Positives = 257/433 (59%), Gaps = 17/433 (3%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 R P+ + LA+WL++ + LH++TID+GLERV V LG+ KP + TVAGTNGKG+TC Sbjct: 16 RRPRQGADLAAWLAHADALHAQTIDMGLERVVKVRDALGL-KPGFPLITVAGTNGKGSTC 74 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L S+L AAGY+VGVYSSPHL+RY ERVR+ G + ++A A++A +E ARG LT F Sbjct: 75 ALLASVLGAAGYRVGVYSSPHLLRYNERVRIDGAPVGDAALCAAYARVEGARGHTPLTPF 134 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E+GTL+A+ +F +A LD +LEVGLGGRLDA N DAD A+VTSI +DH ++LGP RESI Sbjct: 135 EFGTLAAMCVFAEADLDAAVLEVGLGGRLDAVNAFDADCAIVTSIGIDHVEYLGPTRESI 194 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT-DHDWAFSDAHG 243 EK+G+FR+ +PAI +PE P+TIA A+ GA L + G ++ W S G Sbjct: 195 AVEKSGVFRAGRPAICADPEPPATIAQEARRLGARLLQSGRDYRVRRDPGDTWTLSRRSG 254 Query: 244 TLENLPLPLV----PQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSES- 296 L LPLP + NA L AL L V I G+ L GRFQ Sbjct: 255 ELGGLPLPALAGDVQLHNAGACLMALETLARTLPVDAAQIHRGLRQVQLIGRFQRWRRHP 314 Query: 297 --PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 P V+ DVAHNPHAA+ L + P GR LAV ML DKDIAGT L+ VD W+ Sbjct: 315 GAPEVLLDVAHNPHAAQRLALTLTQHPVPGRTLAVFAMLRDKDIAGTAQALRDGVDAWFV 374 Query: 355 APLEGPRG------ATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 A + RG A A + S A+ A+A A +D VLVCGSF TVA Sbjct: 375 AGIAERRGASAADMAAALDAAQVQRTVHLSASPLDAYRDALASAGPDDRVLVCGSFSTVA 434 Query: 409 HVMEVIDARRSGG 421 V+ ++A + G Sbjct: 435 AVLRELEAEATAG 447 >UniRef50_Q1WT76 Folylpolyglutamate synthase / Dihydrofolate synthase n=2 Tax=Lactobacillus salivarius RepID=Q1WT76_LACS1 Length = 433 Score = 444 bits (1144), Expect = e-123, Method: Composition-based stats. Identities = 104/431 (24%), Positives = 187/431 (43%), Gaps = 24/431 (5%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + L+++ L+R+ RLG V GTNGKG+T L Sbjct: 3 VNNYNDALAFIHGRTKFKKIPTLDRMRDFMKRLGNPHEKVKAIHVTGTNGKGSTTAYLRD 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS--------- 120 ++ GY VG ++SP + ++ ER+ V G+ + + I ++ Sbjct: 63 LIAEQGYNVGTFTSPFIEKFNERISVNGKMISDEEIVRLVNIIGPVVKEMDSDWRDREGG 122 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 T FE T F + +D ++EVG+GG D+TN++ ++V+T++A+DH LG Sbjct: 123 PTEFEIVTAMMFVYFAEGHVDYAVIEVGIGGLFDSTNVITPLMSVITTVAMDHAHILGDT 182 Query: 181 RESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT-----D 233 I KAGI + +KP ++G E + VA+EK A L +++ V Sbjct: 183 IAKIATHKAGIIKYKKPILIGKLPDEAIKVVKQVAKEKEAPLLIMDKDFSSKVKLEQGWG 242 Query: 234 HDWAFSDAHGTLENLPLPL---VPQPNAATALAAL----RASGLEVSENAIRDGIASAIL 286 + FSD+ G + N+ + + NA A+ G+ S I++ I Sbjct: 243 EKFDFSDSRGEISNIHISMEGFHQIENATLAIETFIQFAELEGINYSNKDIKNAIQKTQW 302 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 GRF+++++ P V+ D AHN A + ++ ++ + V ++ +L DK L L Sbjct: 303 LGRFELLNKEPLVVIDGAHNTAAMKRISQLLRKEFADREVYVILAILADKQPNEMLDELL 362 Query: 347 SVVD-DWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 + + EGPR T + N K + +A +++ +D +L+ GS + Sbjct: 363 KLPNVHVTVTRFEGPRKVTKLADFKLHDNVKYVEHWQEAIGEVISNMSLDDMLLITGSLY 422 Query: 406 TVAHVMEVIDA 416 ++ V + Sbjct: 423 FISEVRNNFEG 433 >UniRef50_A8PMD7 FolC bifunctional protein n=1 Tax=Rickettsiella grylli RepID=A8PMD7_9COXI Length = 430 Score = 444 bits (1143), Expect = e-123, Method: Composition-based stats. Identities = 175/418 (41%), Positives = 248/418 (59%), Gaps = 9/418 (2%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 + L+ WLSY+E LH ++ GLER+S VA L +L + TVAGTNGKG+ L Sbjct: 11 DSRQLSDWLSYIETLHPHRMEFGLERISHVAENLNLLHFDCPIVTVAGTNGKGSNVGLLA 70 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 +IL AGY+VG Y+SPHL Y ER+RV Q + + +F ++E R SLTYFEYGT Sbjct: 71 AILSVAGYRVGTYTSPHLRHYHERIRVGSQCISDQDLCHAFFQVEKKRLGTSLTYFEYGT 130 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+AL+ FKQ LD++ILEVGLGGRLDA N VDAD++++++IA+DHT WLG RE IG EK Sbjct: 131 LAALYYFKQVPLDLIILEVGLGGRLDAVNCVDADLSIISTIAIDHTQWLGKTREKIGLEK 190 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 A I R+ +P + G+ P+++ + A+ + L R GVE++Y + W++ +L +L Sbjct: 191 AAIMRAYRPCVCGDFSPPTSVLNTAKSLNSPLYRLGVEFDYKMQHSSWSWQSRKRSLHHL 250 Query: 249 PLPLVPQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQIVSESPR-VIFDVAH 305 PLP + NAAT L A+ ++ AI++G+ +PGRF I+ ++ R +I DVAH Sbjct: 251 PLPTIDLQNAATVLQAVELLSERFTIASFAIQEGLKRVFVPGRFHIIEKNARQIIVDVAH 310 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATA 365 NP L+ R+ P G A+ GM+ DKDI T L + VD WY L RGA A Sbjct: 311 NPAGGVCLSKRLANTPCLGETYALAGMMADKDITNTFRPLSNHVDYWYLCDLTEHRGAKA 370 Query: 366 EQLLEHLGNGKS------FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 QL + L + K F S A+ A + + D +L+ GSFHT A + ++ Sbjct: 371 TQLKQSLLDLKVKQSILEFSSPEFAFQRAFSQLRKNDRLLIFGSFHTAAAIYHYLERE 428 >UniRef50_B2J1B6 FolC bifunctional protein n=25 Tax=Bacteria RepID=B2J1B6_NOSP7 Length = 448 Score = 444 bits (1143), Expect = e-123, Method: Composition-based stats. Identities = 129/419 (30%), Positives = 195/419 (46%), Gaps = 27/419 (6%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 ++ + LGL+R+ + A LG V VAGTNGKG+ C L SIL AGY+ G Sbjct: 23 IQPFQRFGVHLGLDRIINLLANLGNPHHQVPVIHVAGTNGKGSVCAYLSSILTEAGYRTG 82 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR--GDISLTYFEYGTLSALWLFKQ 137 Y+SPHLV +TER+ + Q + + +++ D S T FE T +A F Q Sbjct: 83 RYTSPHLVDWTERICLNEQPISSEELSQLLEKVQGVIRPEDESATQFEVITAAAWLYFAQ 142 Query: 138 AQLDVVILEVGLGGRLDATNI-VDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEK 196 Q+DV ++EVGLGGRLDATN+ ++ V ++TSI+ +H LGP I REKAGI + Sbjct: 143 QQVDVAVVEVGLGGRLDATNVCLEPIVTIITSISREHWQQLGPTVADIAREKAGILKPGC 202 Query: 197 PAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVP 254 P +VG + + A E + + ++ + + L PLPL Sbjct: 203 PVVVGQLPLDAEEVVRSRALELKCPIFTPQPARQIATGWAEYQ-TLQNSQLIKYPLPLAG 261 Query: 255 QPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDVAHNP 307 Q A AL L+ G +SE AI G+A PGR Q + + +++ D AHN Sbjct: 262 QIQLANSALAIAALEILQEQGWHISEEAIIKGMAKTQWPGRMQWTTWNNHKILLDGAHNT 321 Query: 308 HAAEYLTGRMKALP--KNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP----- 360 AA+ L + +L + V+GM DKD A A L D + P+ Sbjct: 322 AAAQVLRQYVDSLDAVNPKPITWVMGMFSDKDHADIFAALLRPGDRLFLVPIPVESWTGR 381 Query: 361 RGATAEQLLEH-------LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A + L L + + + A + A++ +D +++CGS + V + Sbjct: 382 TSADLDSLANLAYRLCPQLSDRQIHPDLFTALEVAISTTSTDDLIVLCGSLYLVGDFLA 440 >UniRef50_Q88LD8 Folylpolyglutamate synthetase n=23 Tax=Pseudomonadaceae RepID=Q88LD8_PSEPK Length = 436 Score = 444 bits (1143), Expect = e-123, Method: Composition-based stats. Identities = 199/424 (46%), Positives = 256/424 (60%), Gaps = 14/424 (3%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L WL+YLE LH ID+GLER V ARL + K AP V TV GTNGKG+TC + S+L Sbjct: 6 SLGEWLAYLEQLHPSAIDMGLERSQKVLARLALGKLAPRVVTVTGTNGKGSTCAFVASLL 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 A G KVGVYSSPHL+RY ERV + GQE + +FA +E+ARGDISLTYFE GTL+A Sbjct: 66 RAQGLKVGVYSSPHLLRYNERVVIDGQEASDERLCEAFAAVEAARGDISLTYFEMGTLAA 125 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 WLF Q+QLD V+LEVGLGGRLD N+VDAD A+VTSI +DH D+LG RE + EKAGI Sbjct: 126 FWLFYQSQLDAVVLEVGLGGRLDTVNVVDADFALVTSIGVDHVDYLGDTRELVAFEKAGI 185 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS-----DAHGTLE 246 FR KPA+ G+ + P + D A E A L RG E++ + + W++ A L Sbjct: 186 FRPGKPALCGDLDPPGPLLDKAAELAAPLFLRGREFDLASAEGCWSWRGTAADGAQVELR 245 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQ-----IVSESPRVIF 301 +LPL +P NA AL A GL + +R + + GR + ++ Sbjct: 246 DLPLLDLPMENATLALQAFLLMGLPWNAAQVRQALLDTRITGRLDLRNVNWQGKPVALLL 305 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 DV HNPHAA+YL R+ A P GR LAV G+L DKD+ G +A L+ ++DDW APL+ PR Sbjct: 306 DVGHNPHAAQYLARRLAARPLKGRRLAVFGLLADKDLEGVIAPLQGLIDDWAVAPLDTPR 365 Query: 362 GATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 A +L L N KS+ SV A + A A A+D +L+ GSF VA +E ++ Sbjct: 366 SRPAAELASSLANLGATVKSYVSVDAALEGQCAQATADDQILLFGSFFCVAQALEWLERH 425 Query: 418 RSGG 421 G Sbjct: 426 AQEG 429 >UniRef50_A1UZ44 FolC bifunctional protein n=107 Tax=cellular organisms RepID=A1UZ44_BURMS Length = 461 Score = 444 bits (1142), Expect = e-123, Method: Composition-based stats. Identities = 180/435 (41%), Positives = 238/435 (54%), Gaps = 25/435 (5%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 L +WLS+LE+ H ID+GL R+ V L + A V TV GTNGKG+TC + Sbjct: 26 STFPTLDAWLSHLESAHPVGIDMGLARIGQVKDALKLA-FACPVITVGGTNGKGSTCAFI 84 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR----GDISLTY 123 E+IL+ AGYKVG ++SPHL+R+ ER R+ G+ + + F +E+AR +SLTY Sbjct: 85 ETILVRAGYKVGCHTSPHLLRFNERARLDGRIVDDEELLPHFEAVEAARTSLPEAVSLTY 144 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE+ TL+ + LF LD VILEVGLGGRLDA N++DAD A+VTSI +DH ++LG RE Sbjct: 145 FEFTTLAIMHLFASRGLDAVILEVGLGGRLDAVNVIDADCAIVTSIDVDHIEYLGDTREK 204 Query: 184 IGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSV----TDHDWAFS 239 I EKAGIFR KPAI G+P P T+ D A GA L G ++ +S W ++ Sbjct: 205 IAFEKAGIFRPGKPAICGDPAPPQTLVDHAGAIGADLWLVGRDFRFSTQPGSERQQWTYA 264 Query: 240 DAHGTLENLPLPLVPQPN------AATALAALRASGLEVSENAIRDGIASAILPGRFQIV 293 L P + N AA A L VS IR G+A+ LPGRFQ++ Sbjct: 265 GRDKRYPALAYPALRGANQLLNASAALAALEALRERLPVSAQDIRLGLANVELPGRFQVL 324 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 P V+ DVAHNPHAA L + ++ AV G + DKD+AG + LK +D W+ Sbjct: 325 PGKPLVLLDVAHNPHAAAVLAQNLDSMGYYPYTHAVFGAMADKDLAGIVERLKGAIDHWH 384 Query: 354 CAPLEGPRGATAEQLLEHLG----------NGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 L PR A A+ L L N A A+ A+ A D ++V GS Sbjct: 385 LTDLPLPRAAAADVLERVLRGAGVEHGAQHNITRHAGPADAFLDALKSASDNDRIVVFGS 444 Query: 404 FHTVAHVMEVIDARR 418 F+TVA VM V+D R Sbjct: 445 FYTVAGVMPVVDRRH 459 >UniRef50_Q03EP1 Folylpolyglutamate synthase n=2 Tax=Pediococcus RepID=Q03EP1_PEDPA Length = 424 Score = 444 bits (1142), Expect = e-123, Method: Composition-based stats. Identities = 100/422 (23%), Positives = 186/422 (44%), Gaps = 18/422 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + L ++ + ++R++ +LG + A VAGTNGKG+T L + Sbjct: 1 MDYKTALKFIHGRPRLRKEPTVKRMTAFLDQLGNPQDAIQGIHVAGTNGKGSTIAFLAKM 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT------YF 124 + G +VG ++SP+L R+ ER+ V G + + EI+ ++ T F Sbjct: 61 METTGQRVGTFTSPYLERFNERIAVNGIPIRDDEILTLVEEIKPIVDELDQTPLGGPLEF 120 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T FK+ +D+V++EVG+GGR D+TN+ +V+T+I DH LG I Sbjct: 121 EIVTAMMFLYFKKHPVDIVLIEVGIGGRYDSTNVFTPIASVITNIGWDHMQILGDTLPKI 180 Query: 185 GREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 +KAGI ++ P I G + I + A++ A L+ ++ ++ ++ + A Sbjct: 181 AFQKAGIIKTNVPVITGTEDQAALRVIEEEAKKLHAPLKILKRDFKIDSKENFFSNTFAQ 240 Query: 243 GT-LENLPLPLVPQPNAATALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSESP 297 + + L L N A AL + R +++ + +R + GR +I+ + P Sbjct: 241 IEHIHSGLLGLYQVNNLAVALETMLVVSRQLNWKINYDQLRQAVQHTQWAGRMEIIQKRP 300 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD-DWYCAP 356 ++I D AHN + L ++A +V + +L DK L L + + Sbjct: 301 KIILDGAHNLPGIQALKKSIQAYWPEQKVFILAAILDDKRFEAMLTELVDLKQVELTLTR 360 Query: 357 LEGP---RGATAEQLLEHLGNGKSF-DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 GP +L + + ++ + A + AK D +++ GS + ++ V Sbjct: 361 FNGPIKRAAVDWSELHDPIRKDINYQANWQLALKEILRQAKPSDVIIITGSLYFISEVRP 420 Query: 413 VI 414 + Sbjct: 421 QL 422 >UniRef50_A8MIR1 FolC bifunctional protein n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MIR1_ALKOO Length = 439 Score = 443 bits (1141), Expect = e-123, Method: Composition-based stats. Identities = 110/426 (25%), Positives = 195/426 (45%), Gaps = 24/426 (5%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 + +++ +S L LE + ++ LG + +AGTNGKG+T + S+L A Sbjct: 5 EAVQFIDRSYSYGTKLDLEHMKILLQILGNPQNQLKFIHIAGTNGKGSTSSFIHSMLKAE 64 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR------GDISLTYFEYGT 128 GY+VG+++SPHL YT+R+R+ G + + + +E G F+ T Sbjct: 65 GYQVGLFTSPHLHCYTDRIRINGVNISKEDFARYTSMVEETIAPFYEQGFNHPALFDIVT 124 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGRE 187 L A+ F + +D V+LEVGLGG DATNI+ + +V+T I +DH D LG D + I Sbjct: 125 LVAMMYFAKENVDYVVLEVGLGGLNDATNIISQSLASVITPIGIDHVDILGTDLKQIAYH 184 Query: 188 KAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVE----WNYSVTDHDWAFSDA 241 KAGI +S+ I +P + + + A ++ A L E + + + + Sbjct: 185 KAGIIKSQGRVISTWQDPIVEEVLVETAAQQNASLCLLRKEQISIIHQDFKEQIFHLNTP 244 Query: 242 HGTLENLPLPLVPQPNAAT-ALAAL------RASGLEVSENAIRDGIASAILPGRFQIVS 294 +G L + + ++ ALAAL L +S +I G+ GR +++ Sbjct: 245 YGILRDCKIRMIGDHQIFNGALAALTLIILREDQILSISNESIYQGLYENYWAGRLELLQ 304 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 ++P ++ D AHN +E L + N ++ +IGML DKD+ G L L Sbjct: 305 DNPLILIDGAHNVQGSEVLASALTKYFNNKKITLIIGMLKDKDVDGVLNNLIPFAHKVIF 364 Query: 355 APLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 P+ ++L + ++ ++ A+ +A ++ + GS + + Sbjct: 365 TKPNNPKAMDPQELANRVNFFGKETYITQTIEESVVLALENASLDEITIFTGSLYLIGDA 424 Query: 411 MEVIDA 416 ++I Sbjct: 425 RKIITE 430 >UniRef50_Q5QWH7 Folylpolyglutamate synthase n=2 Tax=Idiomarina RepID=Q5QWH7_IDILO Length = 430 Score = 443 bits (1141), Expect = e-123, Method: Composition-based stats. Identities = 203/426 (47%), Positives = 257/426 (60%), Gaps = 11/426 (2%) Query: 2 IIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 I P + L WL+YLE LH K ID+GLERV+ VAA GVLKPA V TV+GTNGKG Sbjct: 4 ISSSAPAVTASLQEWLTYLEKLHPKNIDMGLERVARVAANAGVLKPAALVITVSGTNGKG 63 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL 121 +T LE+IL AAGY GVY+SPH+ Y ERVRV QELP+S H +F IE AR + SL Sbjct: 64 STVCYLETILQAAGYTTGVYTSPHITEYRERVRVNAQELPDSEHVKAFHAIEQARNNTSL 123 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 TYFE+GTL+ALWL + DV ILEVGLGGRLDA N VDADVAVVTSI +DH +LG +R Sbjct: 124 TYFEFGTLAALWLMGRQSPDVAILEVGLGGRLDAVNCVDADVAVVTSIGIDHIAFLGNNR 183 Query: 182 ESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 E IG EKAGI RS KP I GE ++IA+ A+ GA L + G +++ + D W++ Sbjct: 184 EHIGYEKAGIARSGKPLICGEASPTASIAESAERIGAKLYQVGRDFHRTEYDESWSYRSQ 243 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP-RVI 300 + L +LPLP +P NA+TA+AA+ L VS +AIR+GI A LPGR Q + + V+ Sbjct: 244 NTQLNDLPLPKLPLINASTAIAAIEQLPLPVSLSAIREGITQASLPGRMQPDTVNGIEVL 303 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHNP AA Y + + ++ AV+GML DKD AG L S WY L P Sbjct: 304 LDVAHNPQAAVYASRYLNKFYPQHKIFAVVGMLSDKDHAGVANALSSQASAWYLGSLSEP 363 Query: 361 RGATAEQLLEHLG----NGKSFDSVA------QAWDAAMADAKAEDTVLVCGSFHTVAHV 410 RG TA+ L+ + + F+SV + V GSF+TVA + Sbjct: 364 RGETADNLVINAKLPTESCYLFESVEQAFAAAVTAAQQWQMNDGKALVFGFGSFYTVARI 423 Query: 411 MEVIDA 416 + Sbjct: 424 NAYLKG 429 >UniRef50_C6J218 Bifunctional protein folC n=1 Tax=Paenibacillus sp. oral taxon 786 str. D14 RepID=C6J218_9BACL Length = 462 Score = 443 bits (1141), Expect = e-123, Method: Composition-based stats. Identities = 116/439 (26%), Positives = 196/439 (44%), Gaps = 33/439 (7%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + + A + ++ L I GLER+ L+ +LG + VAGTNGKG++C L Sbjct: 15 RPLNSYAEAVDWINGLLPFGIRPGLERIELMMEKLGHPERRLKFIHVAGTNGKGSSCAFL 74 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SL 121 L GY VG Y+SP++ ++T R + +++PE+ + +I S Sbjct: 75 TRTLRECGYHVGTYTSPYITKFTNRFQYDEEDIPETVLLELANRVAPLVAEIAGTELGSP 134 Query: 122 TYFEYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 T FE T A+ F + DVV+ E GLGGR+D TNIV V+++T+I LDH D LG Sbjct: 135 TMFEVSTAIAILYFAEVCYPDVVVWETGLGGRMDVTNIVTPIVSLITNIGLDHMDVLGDT 194 Query: 181 RESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYS-----VTD 233 E I REKAGI ++ P + +PE + + + A K A L G ++ Y + Sbjct: 195 IEQIAREKAGIIKAGVPVVSCAEQPEAVAVLKETAAAKHATLYLMGEQFRYERVAVDAKE 254 Query: 234 HDWAFSDAHGTLENLPLPLVPQPNAATAL---AALRASG----LEVSENAIRDGIASAIL 286 F + + + ++ + A L + + ++DG ++ Sbjct: 255 QQLHFQGPFREM-DFTIRMLGEHQCKNAAGVMMVLEVLRQYMAFILEDEQVQDGFRTSFW 313 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 GR ++V E PR++ D AHNP A L + + ++ ++GML +K G L + Sbjct: 314 AGRLEVVREEPRLVLDGAHNPEGAASLAKSLPEAFQYRKLHLMMGMLANKHHQGYLKHIL 373 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFD-----------SVAQAWDAAMADAKAE 395 +VD + R A+ L E + + + +A + + E Sbjct: 374 PIVDTLILTEPDFRRKMDADALYELVAELQGIEAKADLEIIVERDWRKALSLLESRTERE 433 Query: 396 DTVLVCGSFHTVAHVMEVI 414 D +V G+ + ++ V + Sbjct: 434 DLGVVTGTLYLISDVRAAL 452 >UniRef50_C5CFS4 FolC bifunctional protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CFS4_KOSOT Length = 443 Score = 443 bits (1140), Expect = e-123, Method: Composition-based stats. Identities = 113/434 (26%), Positives = 197/434 (45%), Gaps = 31/434 (7%) Query: 9 AASPLASWLSYLENLHSKT-IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 L YL + I GL R+ + RLG + + + GTNGKG+ L Sbjct: 2 TVMEYREALEYLYSSRPYGKIKYGLFRIEELMERLGNPQESYPTIHITGTNGKGSVATIL 61 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-------DIS 120 + +L A G VG+ SPH+V + ER+++ + + E + EI A + + Sbjct: 62 KGVLEAHGLHVGMNISPHIVSFRERIQLDNRYITEEEVCETLKEILPAIETMDKKGPEYA 121 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGP 179 ++FE T A F++ ++DV ++EVGLGGR DATNI+ V+V+T+++LDH + LG Sbjct: 122 PSFFEVVTAMAFHFFRKKKVDVAVIEVGLGGRYDATNIIKKPLVSVITTVSLDHKNILGK 181 Query: 180 DRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYS-----VT 232 + E I EKAGI + P + G P + TI + A EK A ++ + Sbjct: 182 NEEKIAIEKAGIIKEGVPVVSGVTRPSIRYTIEEKAGEKNAPSYFLWKDFQVETKELKIN 241 Query: 233 DHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGL-------EVSENAIRDGIASAI 285 ++ + +S T NL L L A A++ + ++ +RD + Sbjct: 242 ENVYNYSGEE-TYPNLVLSLNGTHQARNLAVAMKTLEIAFNGLKKKIDNAKLRDSLKKTS 300 Query: 286 LPGRFQIV-SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAW 344 PGRF+++ ++ ++I D AHN A L ++ ++ + G L DKD ++ Sbjct: 301 WPGRFEVLTHKNRKIILDGAHNIDGAYALRNSLEIYFPGQKLDIIFGSLDDKDYESVISI 360 Query: 345 LKSVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLV 400 L + + R E++ E N + +A++ + T+L+ Sbjct: 361 LAPISGKVVVTKVPSHRSINPERVREIWKVYHGNVEFITEPDRAFEKFFNSTQN--TLLI 418 Query: 401 CGSFHTVAHVMEVI 414 GS + V+++ +I Sbjct: 419 TGSLYLVSYLRNLI 432 >UniRef50_C1D9J6 FolC n=26 Tax=Neisseriaceae RepID=C1D9J6_LARHH Length = 424 Score = 443 bits (1140), Expect = e-123, Method: Composition-based stats. Identities = 174/413 (42%), Positives = 231/413 (55%), Gaps = 14/413 (3%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + LA WLS+LE+LH +IDLGLERV V + + +P V TV GTNGKG+ C L I Sbjct: 5 TTLAGWLSHLESLHLSSIDLGLERVRQVVDAMPL-RPGFPVITVGGTNGKGSVCAMLTRI 63 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L +AGY+VG Y+SPHL+ Y ER+ + + L + A A +E+ RGD+ LTYFE+GTL+ Sbjct: 64 LASAGYRVGTYTSPHLMVYNERIAIDAESLSDEAIVRGLAAVEAGRGDVPLTYFEFGTLA 123 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+W F A++DV ILEVGLGGRLDA N+ + D A V S+ LDH DWLG +RE IG EKAG Sbjct: 124 AMWNFVDAKVDVAILEVGLGGRLDAVNVFEPDCAAVVSVDLDHQDWLGDNREDIGFEKAG 183 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-HDWAFSDAHGTLENLP 249 IFR+ KPA+ +P+ P+ + A GA L G ++ ++ TD W F LP Sbjct: 184 IFRAGKPALCADPQPPARLVGHAAAIGAPLWLAGRDFGFTRTDPLQWEFWCGQSRRHALP 243 Query: 250 LP----LVPQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 P NAA LA L A L V A+R G+ P RFQ++ P + DV Sbjct: 244 TPALRGNYQMGNAALVLAILEAVRDRLPVGAGAVRRGLLEVEWPARFQVLPGRPVTVLDV 303 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRG 362 HNPHA + ++ L R LAV ML DKD+ + K D+W+ AP+ + PR Sbjct: 304 GHNPHAIRAMVSSLQTLNYAERRLAVFSMLADKDVDSVIELAKDEFDEWWVAPIADSPRA 363 Query: 363 ATAEQLLEHLG-----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 L+ L +A A+ A A D + V GSFHTVA + Sbjct: 364 MPVAGLVARLRAHGVTRIHECADLATAYRQAREQATENDRITVFGSFHTVAAI 416 >UniRef50_C6N083 FolC bifunctional protein n=2 Tax=Legionella RepID=C6N083_9GAMM Length = 429 Score = 442 bits (1139), Expect = e-122, Method: Composition-based stats. Identities = 170/419 (40%), Positives = 240/419 (57%), Gaps = 7/419 (1%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P LA WLS LE +++ I LGL R+ VA +L + V TVAGTNGKG+T Sbjct: 4 PYNEWDLAKWLSALETRNTQEIQLGLTRIQEVAQKLKLQNTECRVITVAGTNGKGSTVTA 63 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 LE I AGYKVG Y+SPHL+++ ER+RV + + +F IE+ARG I LTYFE Sbjct: 64 LEHIYHTAGYKVGTYTSPHLIQFNERIRVGLTPISDHDLCMAFRTIEAARGQIILTYFEM 123 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 TL+AL FKQA LD++ILEVGLGGRLDATN++DAD++++T+I DH D+LG ++IG Sbjct: 124 TTLAALLYFKQACLDLIILEVGLGGRLDATNVIDADLSIITTIDFDHQDFLGTTLDAIGY 183 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 EKAGI R KP I + P+TI DVA + E++++ W+ L Sbjct: 184 EKAGILRQRKPFIYADVNPPATIVDVASKLFCPTYFFNQEYSFAEQKASWSIYCGDHQLN 243 Query: 247 NLPLPLVPQPNAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 NLP P + +AA A+ A L A L V+ ++ + +PGR Q+ +++DV+ Sbjct: 244 NLPKPSIQLKSAAAAIMAVFLLARDLPVAFEQVQAAMRQIFIPGRLQLQKGPVSILYDVS 303 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HN +A+ L + +L GR+ AV L DKDI G + LK+ VD WY A L R + Sbjct: 304 HNAQSAKLLADTLYSLDSKGRIHAVFSALKDKDILGLIEPLKNCVDRWYPAQLGVKRAVS 363 Query: 365 AEQLLEHLGNGKS-----FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 A LL + + +++ A++ A+ A+ D ++V GSF TV HV+ RR Sbjct: 364 ANLLLSYFKKAEIYVEICYNNPLLAFETALNQAEPGDLIVVYGSFFTVGHVLAAKPNRR 422 >UniRef50_C1I5V8 FolC bifunctional protein n=1 Tax=Clostridium sp. 7_2_43FAA RepID=C1I5V8_9CLOT Length = 432 Score = 442 bits (1137), Expect = e-122, Method: Composition-based stats. Identities = 116/425 (27%), Positives = 194/425 (45%), Gaps = 25/425 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + YLE L + GLER + LG + +AGTNGKG+T L +L+ GY Sbjct: 7 IKYLEELRVLGSNYGLERTERLLELLGNPHKKLKLIHIAGTNGKGSTSSILGKVLIEHGY 66 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEYGTLS 130 KVG ++SPHL E +RV + +PE EI+ G T FE T Sbjct: 67 KVGFFNSPHLEEIEETIRVNDENIPEEDLVYLLEEIKPYVNKVVEEGYKHPTEFEVLTCI 126 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 + ++D ++EVGLGGRLD+TN++ ++++TSI+LDHT+ LG + I EKAG Sbjct: 127 MFLYLYRQKVDFGVIEVGLGGRLDSTNVIKPILSIITSISLDHTNILGNTIQEITNEKAG 186 Query: 191 IFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRG---------VEWNYSVTDHDWAFS 239 I + P I E I + A + L V + F+ Sbjct: 187 IIKDAIPVITCNQKDEALYIIKNKALLTKSKLTIVDSNDFVFLEIVNDDIPYQRVSVNFN 246 Query: 240 DAHGTLENLPLPLVPQPNAATALAALRASG----LEVSENAIRDGIASAILPGRFQIVSE 295 + TL+ L N + A+ AL ++V+ N + G+ + GR +++ + Sbjct: 247 NNKYTLDLALLGKHQIINLSLAIKALEELEKLNYIKVNINKLYKGVKNVKWKGRLEVLKK 306 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 P ++ D AHN E+L ++ K + ++G+L DK++ + + V + Y Sbjct: 307 DPFIVIDGAHNIAGIEFLKSNIEEYFKYKNLYLILGILADKNVEEMVKIIAPVATEVYTV 366 Query: 356 PLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 R A+A +L E + N +FD +A +++ A +D ++ GS + + + Sbjct: 367 TANSIRAASANELKEVVLEYNNNCIAFDDYDKAIKLSLSKANKDDLIVAAGSLYMIGEIR 426 Query: 412 EVIDA 416 + I+ Sbjct: 427 KQINN 431 >UniRef50_B2V618 FolC bifunctional protein n=3 Tax=Sulfurihydrogenibium RepID=B2V618_SULSY Length = 413 Score = 441 bits (1136), Expect = e-122, Method: Composition-based stats. Identities = 110/401 (27%), Positives = 192/401 (47%), Gaps = 10/401 (2%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 L + I+ GLER+ L + VAGTNGKG+T LES+L GYK G Sbjct: 7 LFQKKAFNIEPGLERIRSALKELNNPEKNFKSILVAGTNGKGSTSAYLESLLRHYGYKTG 66 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQ 139 +++SPHL+R ER ++ +E+ + E++ +LTYFE TL A F + Sbjct: 67 LFTSPHLIRENERWQIDRKEIDDKKLQNYINELKPIIEKYNLTYFEACTLLAFKYFSDKK 126 Query: 140 LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI 199 +D+ ++EVGLGGR D+TN+++ + +V+T+++ DH LG I EK GI R +KPA+ Sbjct: 127 VDIAVVEVGLGGRWDSTNVLEPETSVITNVSFDHMHMLGNTLLDIAYEKTGITRQDKPAV 186 Query: 200 VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-HDWAFSDAHGTLENLPLPLVPQPNA 258 +G + P I + + K + +++ D + + + ENL + ++ + Sbjct: 187 IGRNQ-PEIIHWLKERKIKEYYIKDIDYFVKEIDFNKYNYKFKEHIFENLEISMLGKRQI 245 Query: 259 ATA-------LAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAE 311 + L L + V EN IR + + GR +I+S++P +I D AHN Sbjct: 246 ENSSLALTTFLLFLDKNNQPVVENIIRKALYNTKWKGRMEIISKNPFIIIDGAHNEEGLI 305 Query: 312 YLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEH 371 +K + N ++ + + DKD + +K D + + R TAE ++ Sbjct: 306 KTFQEIKEIFPNKKIFTIFSFMKDKDTEKMINIIKQNSDFYIATVMPFSRAMTAED-FKN 364 Query: 372 LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 LG ++ +A + +L+ GS + + +++ Sbjct: 365 LGIENVKENHLEAVKELKNSVDKDTIILITGSLYLIGEILK 405 >UniRef50_Q0A999 FolC bifunctional protein n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A999_ALHEH Length = 437 Score = 440 bits (1134), Expect = e-122, Method: Composition-based stats. Identities = 175/429 (40%), Positives = 242/429 (56%), Gaps = 19/429 (4%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 + L WL + E L I+ GLERV V RLG L P V TVAGTNGKG+ Sbjct: 13 QRDRWRLEDWLRWQEGLSPVEINPGLERVQAVGERLGALTPRCPVITVAGTNGKGSCIAY 72 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 LE++L AAGY+ Y+SPHL+RY ER+R+ G + + A TA+F+ +E AR LTYFEY Sbjct: 73 LEAMLGAAGYRTAAYTSPHLLRYNERIRLAGVPVSDEAITAAFSRVEQARQGTPLTYFEY 132 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 GTL+AL LF +A+ +V +LEVG+GGRLDA N VD D++++TSI LDHT+WLG DRE IG Sbjct: 133 GTLAALSLFSEAEAEVWLLEVGMGGRLDAVNAVDPDLSIITSIGLDHTEWLGADRERIGA 192 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 EKAGI R +P +G+ ++P +++D A+ A + G ++++ W + L+ Sbjct: 193 EKAGIMRPGRPVCLGQADLPDSVSDRARTLRAPVTAAGRDFHWRRQALGWDWLSGDERLD 252 Query: 247 NLPLPLV----PQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQIV-SESPRV 299 LP P + NAA +A LR L V A+ G+ SA LPG + V Sbjct: 253 GLPWPGLTGTVQLDNAAVVIAGLRRLRERLPVDRAALERGLRSARLPGHMERVRRRGVEW 312 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 +FDVAHN + L ++ GRV+ + +H K ++G LA + +VVD+WY LE Sbjct: 313 LFDVAHNEDSVRVLAETVRDEAGKGRVIGLFAAMHRKALSGVLATMGAVVDEWYLPRLED 372 Query: 360 PRGATAEQLLEHLGNGKSFDSVA-----QAWDAAMA-DAKAEDTVLVCGSFHTVAHVMEV 413 P+ E + L SV A AA+A A+ D V+V GSF TV VM Sbjct: 373 PQAHPPEAVAAGLRETGVDASVIHTGGLSALLAAVADRARPGDRVVVFGSFRTVEAVM-- 430 Query: 414 IDARRSGGK 422 R+GG+ Sbjct: 431 ----RAGGR 435 >UniRef50_A7C245 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Beggiatoa sp. PS RepID=A7C245_9GAMM Length = 441 Score = 440 bits (1133), Expect = e-122, Method: Composition-based stats. Identities = 174/432 (40%), Positives = 247/432 (57%), Gaps = 28/432 (6%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + L WL++ +LH I+LGL+RV+ VA RL +L P + TVAGTNGKG++ L+S Sbjct: 3 FTTLKQWLNWQSSLHPTEIELGLDRVTTVAKRLNLLPPPFPIITVAGTNGKGSSIILLDS 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 IL AGY VG + SPHL+RY ER+ V G E + +F IE RG+ISLTYFE+ TL Sbjct: 63 ILSTAGYHVGRFMSPHLLRYNERICVGGVEASDVQICHTFELIEKVRGEISLTYFEFSTL 122 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +A+ +F+ Q+D+ +LEVGLGGRLDA NI DAD+ +VT+I +DHTDWLG DRESIG EKA Sbjct: 123 AAMLIFQHNQVDIAVLEVGLGGRLDAVNIFDADITLVTAIDIDHTDWLGNDRESIGFEKA 182 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNY-SVTDHDWAFSDA------- 241 GIFR+ PA+ + P ++ + A+ L +++Y D + ++ Sbjct: 183 GIFRAHCPAVCSDTNPPQSLINYAEHLKTPLYYLNHDFSYFKKADKNPSWQMKCHLKSLP 242 Query: 242 ---------HGTLENLPLPLV----PQPNAATALAALRAS--GLEVSENAIRDGIASAIL 286 +LPLP + NAA L L V + AI G+ IL Sbjct: 243 LSPINKKKYQYIFSHLPLPNLVGDFQLQNAAGVLMVLALLSDRFPVLDAAIHQGLTHLIL 302 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 PGRFQI+ I DV HNP A+ L ++ P G AV+GML+DKDI L ++ Sbjct: 303 PGRFQILKGRVTRILDVTHNPLGAKVLAKLLEQHPCEGETHAVVGMLNDKDITSVLTIMQ 362 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADAKAEDTVLVC 401 + +D W+ APL+ R A + L+++L S+ S+ +A++ +A A D ++V Sbjct: 363 NSIDHWHVAPLDTARSADIDVLIDNLTTLGITLIYSYSSIQEAYEEWLAYAPDGDRIVVF 422 Query: 402 GSFHTVAHVMEV 413 GSF+ VA +EV Sbjct: 423 GSFYAVAEALEV 434 >UniRef50_B0S2B5 Folylpolyglutamate synthase n=2 Tax=Finegoldia magna RepID=B0S2B5_FINM2 Length = 415 Score = 440 bits (1133), Expect = e-122, Method: Composition-based stats. Identities = 113/410 (27%), Positives = 202/410 (49%), Gaps = 15/410 (3%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 YL+ + LGL+R+ LG + + + VAGTNGKG+T + L GYK Sbjct: 8 EYLDKIGRDGYKLGLDRMQKTLKILGNPEKSFKIIHVAGTNGKGSTSTFIYQTLKEHGYK 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSALWLF 135 G+++SPH++ + +R+++ +E+ E F I+ DI ++ FE+ TL A++ F Sbjct: 68 TGLFTSPHIINFYDRIKID-KEISEEDFMRIFEIIKDTIEKNDIKVSTFEFITLCAIYYF 126 Query: 136 KQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIFRS 194 + + + V+LEVG+GGRLDATN D ++V+T I LDH ++LG E I EKA I + Sbjct: 127 AEQKCEYVVLEVGMGGRLDATNATDETLLSVITKIGLDHQEYLGNTLEEIAYEKACIMKQ 186 Query: 195 EKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEW--NYSVTDHDWAFSDAHGTLENLPL 250 +V + + + +VA+E+ L + N + +F + +E + Sbjct: 187 NGRCVVYDQQESVLDVFREVAEERNNKLYICDFDEAKNIEINATHNSFDWKNLHIETRLV 246 Query: 251 PLVPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPH 308 NA AL A+ L++S+ I +G +A +P RF ++ +P VI+D HN Sbjct: 247 GRYQLFNAQLALTAIDVLRDELDLSDEDIINGFKNAYIPARFDVIRHNPTVIYDGGHNAD 306 Query: 309 AAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL 368 + L ++++ + +++ V G+L DKD + + + + PR AE L Sbjct: 307 GVKALKSSIESVFGDKKIVFVYGVLKDKDYNDEIKLIHENAKAFVTFTPDSPRALKAEDL 366 Query: 369 LEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 + + N + +V A D A+ +D +++ G+ ++ E + Sbjct: 367 KKQIEVYSDNVVAKSNVNDAVDYAIEHF-KDDVIIIFGTLYSAEQAYEHL 415 >UniRef50_C6AMR7 FolC bifunctional protein n=3 Tax=Pasteurellaceae RepID=C6AMR7_AGGAN Length = 448 Score = 440 bits (1132), Expect = e-122, Method: Composition-based stats. Identities = 220/446 (49%), Positives = 278/446 (62%), Gaps = 36/446 (8%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 ++ +A +PL WLSYLEN H K IDLGLERV VA L +L PAP+V TV GTNGKGT Sbjct: 1 MQTELKATTPLNEWLSYLENSHFKAIDLGLERVKSVAQELDLLTPAPYVITVGGTNGKGT 60 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 TCR LE+IL+ AGY VGVYSSPHL+RY ERVR+Q QEL ++ HTASFA IE+ + SLT Sbjct: 61 TCRLLETILLNAGYSVGVYSSPHLLRYNERVRIQNQELDDAQHTASFAYIEAHKSQ-SLT 119 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+ TLSAL LFK A+LDVVILEVGLGGRLDATNIVD +AV+TSI +DHTD+LG RE Sbjct: 120 YFEFSTLSALHLFKCAKLDVVILEVGLGGRLDATNIVDNHMAVITSIDIDHTDFLGSTRE 179 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 IG EKAGIFR+ KP I+GEP +P + D A + G+ R ++W +S W + Sbjct: 180 QIGFEKAGIFRANKPVIIGEPMIPQAMLDRANQLGSQHFCRHLDWTFSQQGQSWTWQTTQ 239 Query: 243 -------GTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSE 295 L +LPL +P NAATALAA++ E+S + ++ +A L GRFQ + Sbjct: 240 SDEKVRWNFLTDLPLCQIPLANAATALAAVQKLPFEISLDVVKKSLAEVELIGRFQTLKP 299 Query: 296 S----------------PRVIFDVAHNPHAAEYLTGRMKALP--KNGRVLAVIGMLHDKD 337 P++I DV HNPHAA YL ++ AL NG+ +AV GML DKD Sbjct: 300 ECLAHLAQKLNRHVSQLPQMIIDVGHNPHAARYLAEKLTALKAQSNGKFIAVCGMLKDKD 359 Query: 338 IAGTLAWLKSVVDDWYCAPLEGPRGATAEQLL----------EHLGNGKSFDSVAQAWDA 387 G L L ++D+W C L G RG T EQL + + G +SVA+ + Sbjct: 360 AEGVLEPLLPLIDEWRCVTLGGYRGQTGEQLFVTLQQTARLHQKVVKGSYSNSVAEGVKS 419 Query: 388 AMADAKAEDTVLVCGSFHTVAHVMEV 413 A+ + DT+LV GSFHTV + Sbjct: 420 AVEISNENDTLLVFGSFHTVGEFLTY 445 >UniRef50_C0CPE6 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0CPE6_9FIRM Length = 448 Score = 440 bits (1132), Expect = e-122, Method: Composition-based stats. Identities = 113/430 (26%), Positives = 181/430 (42%), Gaps = 28/430 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 ++Y++ T LE RLG + A V VAGTNGKG+TC L S+L Sbjct: 19 YNEAVAYIDETPKFTTKNSLEHTRECLRRLGNPQEAFRVIHVAGTNGKGSTCAFLTSMLR 78 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEY 126 AGY G+++SPHL+ ER ++ + A+F ++ A+G TYFE Sbjct: 79 EAGYSCGLFTSPHLIEINERFQINEVPVDNEIFLAAFHRVKEMADELVAQGSHHPTYFEM 138 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIG 185 L + +FK+A +D V LE GLGGRLDAT ++ V+TSI++DH ++LG E I Sbjct: 139 LFLMGMLIFKEAGVDYVTLETGLGGRLDATTSIENPMACVITSISMDHMEYLGNSLEEIA 198 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD--HDWAFSDA 241 EKAGI P I + AQE G+ + + FS Sbjct: 199 SEKAGIIVPGVPVIFDGNHGAAAEVVRKKAQELGSPFYEVCEADCEILRNTRDGIDFSMK 258 Query: 242 HGTLEN--LPLPLVPQPNAATALAALRASG-----LEVSENAIRDGIASAILPGRFQIVS 294 +G E +P V + A AL+ + ++ G+A GR + V Sbjct: 259 NGYYEKNIFSIPFVARYQVMNAALALKTMEVMREQFSFTTRQLQMGMAQTRWQGRMETVL 318 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS--VVDDW 352 P VI D AHN + + ++ + + DKD + + +D Sbjct: 319 --PGVIVDGAHNEDGVFRFVETARYFQEESKITLLFSAVSDKDYKDMIRTICQGIHLDQV 376 Query: 353 YCAPLEGPRGATAEQLLEHLG-----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 ++G R A++L + + + + +A+ A + + + GS + V Sbjct: 377 VTTQIDGYRVVPAQELAQLFRDCGCSDVIAEPEIPKAFVQARKK-QGDGLLFCVGSLYLV 435 Query: 408 AHVMEVIDAR 417 + + I + Sbjct: 436 GEIKDEIRRQ 445 >UniRef50_B9L391 Folylpolyglutamate synthase (Folylpoly-gamma-glutamatesynthetase) n=2 Tax=Thermomicrobia (class) RepID=B9L391_THERP Length = 454 Score = 439 bits (1131), Expect = e-122, Method: Composition-based stats. Identities = 141/406 (34%), Positives = 204/406 (50%), Gaps = 22/406 (5%) Query: 31 GLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYT 90 GL R + + + LG +AGT GKG+T L S+L AAGY+VG+Y+SPHL Sbjct: 34 GLARTAWLCSALGDPHRRYRSVHIAGTKGKGSTAALLSSMLQAAGYRVGLYTSPHLHTLR 93 Query: 91 ERVRVQGQELPESAHTAS---FAEIESARGDISL-----TYFEYGTLSALWLFKQAQLDV 142 ER+++ GQ + AE+++A T FE T+ A F + +D+ Sbjct: 94 ERIQIDGQPIAPETFGTLMAELAEVDAALQRAHPDWGAATAFELVTVLAFAAFARVPVDI 153 Query: 143 VILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE 202 ++EVGLGGRLDATN++ DVA++T I DH LG +I REKAGI + +P + Sbjct: 154 AVIEVGLGGRLDATNVILPDVALITRIGYDHMAILGSTLAAIAREKAGIVKPGRPVVSAP 213 Query: 203 PEMPS--TIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAAT 260 E + I VAQE+GA L G +W + T +AF L +L L L Sbjct: 214 QEPEATRVIEAVAQERGAPLWLGGRDWQVTGTWRRFAFHAPGWELADLALALRGSHQVEN 273 Query: 261 ALAALRASGLE------VSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLT 314 A AL + E+AIR G+A+A+ PGR +++ E+P V+ D AHN +A+ L Sbjct: 274 AGVALASLPWLARVEMVAPESAIRQGLATAVWPGRLELLRENPSVVVDGAHNRESAQRLA 333 Query: 315 GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL-- 372 + + R+ V+G++ DK+I +A L + D + PR A+AE+LL Sbjct: 334 EAVHESFRWRRLWLVLGIMRDKEIERIVAALAPLADALFAVEGFAPRAASAERLLAAWAA 393 Query: 373 ----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 S+ SV A AA+ A D VLV GS VA E + Sbjct: 394 STVGKPAASYRSVEDALRAALEQADPADLVLVTGSLSMVAAAREAL 439 >UniRef50_C9L620 Tetrahydrofolate synthase n=1 Tax=Blautia hansenii DSM 20583 RepID=C9L620_RUMHA Length = 432 Score = 439 bits (1130), Expect = e-122, Method: Composition-based stats. Identities = 126/430 (29%), Positives = 197/430 (45%), Gaps = 21/430 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 YL+ LGLE + + RL + + ++GTNGKGT L +IL Sbjct: 3 YEEARVYLDETSKYGSVLGLENMKALLDRLDNPQESLKFIHISGTNGKGTVLAYLSTILR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LTYFEY 126 AGY+ G Y SP L Y ER++V +++ + A I +A D+ T FE Sbjct: 63 KAGYRTGRYISPTLFSYRERIQVNEEKIEKEALAQHVTAIAAAVADMKEKKAGTPTAFEI 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIG 185 T A FK+ D+V+LE GLGG LDATNI+ + V+ I++DHTD LG + I Sbjct: 123 ETALAFLYFKEKNCDIVVLETGLGGALDATNIIQTTQLEVIAPISMDHTDVLGKTLKEIA 182 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 +KAGI + + E E + V +EK + + + S ++ Sbjct: 183 AQKAGIIKPHTTMVTAVQEEEAKEVLQKVCKEKESRFCEVEKDEISDIQYGYIRQSFSYK 242 Query: 244 TLENLPLPL---VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 +N+ + L N A AL A LR GL + A+ G+ A GRF ++S++P Sbjct: 243 NWKNVEISLAGEFQIQNGALALEAVNQLRKLGLSLPNEAVYAGMKEAKWVGRFTVMSQNP 302 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA-P 356 VI D AHNP AAE L ++ K ++ V G+ DKD + + + Sbjct: 303 LVILDGAHNPQAAEALRKSLELYFKGKKLYYVFGVFQDKDYKKIIELTAPLAEHIITVET 362 Query: 357 LEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 + PR AE+L + + + ++ +S+ A + ++ AED ++V GS + + Sbjct: 363 PDNPRALPAEELKKQVEKINASVETGESIEAAIEKNLSYMGAEDVLVVFGSLSFLGIAAK 422 Query: 413 VID-ARRSGG 421 V+ R G Sbjct: 423 VLQGGGRKNG 432 >UniRef50_A1HP48 FolC bifunctional protein n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HP48_9FIRM Length = 429 Score = 439 bits (1130), Expect = e-121, Method: Composition-based stats. Identities = 132/424 (31%), Positives = 205/424 (48%), Gaps = 20/424 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L YL L+ I+LGL R+ + +G + V GTNGKG+T L +I Sbjct: 1 MTYQQALEYLATLNKFGINLGLARIKRLLDLMGHPERRYRTVHVTGTNGKGSTTAMLAAI 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPES------AHTASFAEIESARGDISLTYF 124 L A+G K G+Y+SPHLV YTER+ V G+ + +T F E +A G T F Sbjct: 61 LQASGIKTGMYTSPHLVDYTERMVVDGRPAAPAAFAAAIDYTRRFIEQMTAEGWEHPTEF 120 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E T +A F +A+++ ++EVGLGG LD+TN++ + AV+T++AL+HTD G I Sbjct: 121 EVLTAAAFHYFAEAKVEYAVIEVGLGGLLDSTNVISPEAAVITNVALEHTDRCGATVREI 180 Query: 185 GREKAGIFRSEKPAIV-GEPEMPSTIADVAQEKGALLQRRGVEW------NYSVTDHDWA 237 R KAGI ++ P I E E + I + A G++L RG ++ Y Sbjct: 181 ARHKAGIIKAGVPVITAAEGEALAVIREAAAACGSMLYVRGRDFVGEYLGRYDYGQRVAV 240 Query: 238 FSDAHGTLENLPLPLVPQPNAAT-ALAALRAS-----GLEVSENAIRDGIASAILPGRFQ 291 + G L L L+ + A+A + A G ++ +A+ G+A+A PGRF+ Sbjct: 241 HTAQTGRLGPFSLTLLGRHQVENCAIAVMTALVLAERGAPITPDALAAGLAAARWPGRFE 300 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 + P ++ D AHNPH A L + + + ++G+L DKDI G + L D Sbjct: 301 VFPGEPVIVVDGAHNPHGARALRVALDEVFGGRPITFLLGILRDKDITGIVRALVRPQDM 360 Query: 352 WYCAPLEGPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 A R A ++ + G+ + S+A A A A+ V GS + + V Sbjct: 361 VVAAAPLSERAAAPGEIAREIGGSVEEAPSIAAGLAQARRLAGADGVVCAAGSLYLIGAV 420 Query: 411 MEVI 414 +++ Sbjct: 421 RQIL 424 >UniRef50_Q0AGX2 FolC bifunctional protein n=1 Tax=Nitrosomonas eutropha C91 RepID=Q0AGX2_NITEC Length = 428 Score = 439 bits (1129), Expect = e-121, Method: Composition-based stats. Identities = 193/419 (46%), Positives = 256/419 (61%), Gaps = 19/419 (4%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + L WL YLE LH K ID+GLERV V LG+ P V TVAGTNGKG+ C LES Sbjct: 6 SMTLDDWLLYLEKLHPKAIDMGLERVKKVRDALGL-MPKFPVITVAGTNGKGSVCTILES 64 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYG 127 IL A Y+VG Y+SPHL+ Y ER+R+ + + + FAEIES R ++LTYFE+G Sbjct: 65 ILGRASYRVGCYTSPHLLHYGERIRIDQRAITDEVLCGVFAEIESVRESVQVTLTYFEFG 124 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 TL+A+ +F +AQ+DV ILEVGLGGRLDA N+ D D A++TSI LDH D+LG RE+IG+E Sbjct: 125 TLAAMLIFVRAQVDVAILEVGLGGRLDAVNVFDTDCAILTSIDLDHMDYLGSTREAIGQE 184 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 K GIFR KPAI EP++P+ + + GALL + Y+ + W + N Sbjct: 185 KIGIFRPNKPAICTEPDIPAGLLPKMKATGALLCCINKNFGYTQDNLQWCYEG--VRRYN 242 Query: 248 LPLPLV-PQPNAATALAALRASG-----LEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 L LP + + A AAL A L V NAIR G+A A L GRFQI+S P +I Sbjct: 243 LSLPALKGEYQLQNASAALAALEAMEGTLPVPMNAIRRGLAEATLAGRFQIISARPVIIL 302 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 DVAHNP A L ++A+P G A++GML DKD+AGT+ LK+ VD W A L+ R Sbjct: 303 DVAHNPAATRKLLANLEAMPVKGCTYAIVGMLKDKDMAGTIRVLKNNVDQWLIAGLDVAR 362 Query: 362 GATAEQLLEHLGN--------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 GAT ++L+ LG+ + F +V A+ A A ++D + V GSFHTV+ +++ Sbjct: 363 GATGNEILKALGDAGIAEQECVRVFQNVQSAYVYAREHAGSDDRICVFGSFHTVSSILK 421 >UniRef50_Q6AJ73 Related to folylpolyglutamate synthase n=3 Tax=Deltaproteobacteria RepID=Q6AJ73_DESPS Length = 441 Score = 438 bits (1128), Expect = e-121, Method: Composition-based stats. Identities = 130/434 (29%), Positives = 202/434 (46%), Gaps = 23/434 (5%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 I S L++L++L I LGL + A + V VAGTNGKG+ Sbjct: 4 ISDQATIESRYQDALAFLDSLQFHKIKLGLAPMRDFLALFDNPEAKMKVVHVAGTNGKGS 63 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 C +L S+L GY++G+Y+SPHL ER R+ + + + I + +T Sbjct: 64 VCSSLVSVLAKGGYQLGLYTSPHLSSPRERFRINDEYISRADFACLTDRIRTRLAGRPIT 123 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDR 181 YFE+ T A F + +D+V+LE GLGGRLDATN+V + ++TSI++DH +LG Sbjct: 124 YFEFTTALAFLWFYERGVDLVVLETGLGGRLDATNVVRQPLLTIITSISIDHVAYLGDTI 183 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSV-TDHDWAF 238 E++ EKAGI + P + G +P++ + +A A+EK A L G +++ W + Sbjct: 184 EAVASEKAGIIKEGVPVVCGSYDPKVVAVVAGFAREKKAPLYLAGRDFDAHWLAGASWDY 243 Query: 239 SDAH-------GTLENLPLPLVPQPNAATALAA---LRASGLEVSENAIRDGIASAILPG 288 +EN + N A L L+ G VSE+ +R G+ S PG Sbjct: 244 QGEGFLADASLQAVENAKPGRIQAENGALVLTTLCLLKRHGFVVSEDELRSGLFSVSWPG 303 Query: 289 RFQIVS--ESP-RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 R + + SP + D AHNP L + AL R++ V G + DKDIA L + Sbjct: 304 RLEYLQLDRSPAPYLLDGAHNPAGIASLVEAL-ALYSYRRLICVWGAMADKDIATGLNRI 362 Query: 346 KSVVDDWYCAPLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLV 400 VD ++ R A + L F S + A + A A +D +L+ Sbjct: 363 VPHVDLLCLTAVDSERAAEPAAMFALLTEDDRKKTTCFTSSSLALEYAERMAGKDDLILI 422 Query: 401 CGSFHTVAHVMEVI 414 GS + + + ++ Sbjct: 423 AGSLYLMGELRPIL 436 >UniRef50_C8ZWR3 FolC family protein n=26 Tax=Enterococcus RepID=C8ZWR3_ENTGA Length = 446 Score = 438 bits (1128), Expect = e-121, Method: Composition-based stats. Identities = 102/440 (23%), Positives = 178/440 (40%), Gaps = 32/440 (7%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + ++ + GL RV+ + G + +AGTNGKG+T L Sbjct: 2 FKTGDEAVRWIHSRKKFGSRPGLIRVNELLKLCGHPEKNSIGIHIAGTNGKGSTVTYLRC 61 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LT 122 +L VG ++SP++ + ER+ + G+ + E + +T Sbjct: 62 LLEMQKLAVGTFTSPYIESFYERISINGKAISAEEFVQLANEFRPLVDSMDEDTRYQGIT 121 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 FE T A F Q D+ I E G+GG+ D+TN+ + +T+I LDHTD LG E Sbjct: 122 EFEILTAMAFSYF-QKHADIAIFEAGIGGKWDSTNVFIPILTAITTIGLDHTDILGETEE 180 Query: 183 SIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNY----------- 229 I +KAGI + P + G I +VA +K A L ++ + Sbjct: 181 EIALQKAGIIKKNIPIVTGNISQNAVKIIEEVASKKNAPLSKKNTSYQVHYVKQSPESHS 240 Query: 230 ---SVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAAL-------RASGLEVSENAIRD 279 S++ + F + NL +PL + A AL + + + +I+ Sbjct: 241 PKDSISGEMFHFENEDFQFLNLRIPLCGKYQVENAATALQLFLLYCQQQNKAIQKESIQK 300 Query: 280 GIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIA 339 + A PGR + +S P +I D AHNPHA + + + G+ + L K+ Sbjct: 301 ALEKARWPGRMEKISSQPTIIIDGAHNPHAIKEFVDTVTEKFQQGKKYILFSALTTKNSR 360 Query: 340 GTLAWLKSVVDD-WYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTV 398 + ++ + ++ + P+ E L+ K + Q +A ++DT+ Sbjct: 361 KMIRQMQQIPNNCLIITTFDYPKALKKEDLVRENSQFKYYQEWQQGIKEIVAKMGSKDTL 420 Query: 399 LVCGSFHTVAHVMEVIDARR 418 + GS + V+ V + R Sbjct: 421 FITGSLYFVSQVRTYLLDDR 440 >UniRef50_A6GNX1 FolC bifunctional protein n=1 Tax=Limnobacter sp. MED105 RepID=A6GNX1_9BURK Length = 468 Score = 437 bits (1126), Expect = e-121, Method: Composition-based stats. Identities = 189/451 (41%), Positives = 251/451 (55%), Gaps = 39/451 (8%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P A + L WL+YLE++HSK ID+GL+R+ +V + VFTVAGTNGKG+TC Sbjct: 16 PNADASLNDWLAYLESIHSKPIDMGLDRLKVVQQHMNFTLKGV-VFTVAGTNGKGSTCAM 74 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES--ARGDISLTYF 124 LESIL+ AGYKVG+Y+SPHL+R+TER R+ G+E+ ES ++F ++E ISLTYF Sbjct: 75 LESILIQAGYKVGMYTSPHLIRFTERARINGEEVSESELISAFEKVEQTRVATGISLTYF 134 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E+ TL+ +F + L+ VILEVGLGGRLDA NI DAD A+ TS+ +DH +LGPDRESI Sbjct: 135 EFTTLAVALVFSRLDLEAVILEVGLGGRLDAVNIFDADCAICTSVDIDHQAFLGPDRESI 194 Query: 185 GREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 GREKAGIFR KPAIVG+P+ P ++ D A GA L ++NYS WA+ Sbjct: 195 GREKAGIFRPGKPAIVGDPKPPQSVIDHANSIGADLWLFSRDYNYSGDKQQWAYGGRSMR 254 Query: 245 LENLPLPLVPQPNAATALAALRAS------GLEVSENAIRDGIASAILPGRFQIVSESPR 298 L P + N +A A+ L V +IR G PGRFQ++ P Sbjct: 255 RAALAYPALRGTNQLLNASAALAALESVRDRLPVPAQSIRQGFLLVEWPGRFQVLPGQPT 314 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 V+ DV HNPHAA +L + + + GML DKD + LK VD W+ PLE Sbjct: 315 VVLDVGHNPHAAAHLRESLDNMGFFPYTHCIFGMLADKDAVEVVKALKDRVDHWHLVPLE 374 Query: 359 GPRGATAEQLLEHL------------------------------GNGKSFDSVAQAWDAA 388 G RG + EQL + L + +S++SV QA+ Sbjct: 375 GDRGRSTEQLKQQLELAGVDAGAFDWVANSQALAKGGIAKQPPEKSVQSYESVGQAYAVV 434 Query: 389 MADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 + D +LV GSF VA M+ +A R Sbjct: 435 TSAVPPNDRILVFGSFLVVAQAMQAKEALRK 465 >UniRef50_UPI0001C42143 folyl-polyglutamate synthetase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C42143 Length = 442 Score = 437 bits (1125), Expect = e-121, Method: Composition-based stats. Identities = 114/433 (26%), Positives = 206/433 (47%), Gaps = 23/433 (5%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + + ++ +L I GL+R+ + ARLG + + GTNGKG+T L Sbjct: 1 MRNVEEAIEWIHSLLPFGIKPGLKRMEWMLARLGHPERELKTIHIGGTNGKGSTVSYLRH 60 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTY 123 +L A+ YKVG ++SP++ + ER+ V G+ +P ++++ ++ S T Sbjct: 61 MLEASSYKVGTFTSPYIECFEERISVNGEPIPGDDLLECASKVKPLVEELEKTELGSPTE 120 Query: 124 FEYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 FE T F ++ D V++EVGLGGRLD+TN++D ++++TSI DH LG E Sbjct: 121 FEVITTIGFLYFATVSKPDFVLVEVGLGGRLDSTNVIDPLLSIITSIGHDHMHILGDSLE 180 Query: 183 SIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSV-----TDHD 235 I EKAGI + KP I G +PE + + A E+ A L++ ++ + Sbjct: 181 DIAFEKAGIIKYGKPVISGVSQPEAKQVLKEKAAEEKAALKQLNEDFEQVLITRNAASQM 240 Query: 236 WAFSDAHGTLENLPL---PLVPQPNAATALAALRASG----LEVSENAIRDGIASAILPG 288 ++F + + + + NAA AL A+ G +E+ + + G+ +A G Sbjct: 241 FSFYSQRLSFDTCTIQMAGKHQRNNAALALEAMITLGELGIIELDTDLVLKGLKNASWAG 300 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 RF++V++ P +I D AHN L + + + V+ +KD+ LA +++ Sbjct: 301 RFEVVNKEPVIILDGAHNEEGMSALAETLTSHYPDKHYKLVMAATKEKDMKKLLAPFETM 360 Query: 349 VDDWYCAPLEGPRGATAEQLLEHL--GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 D+ + R A+ +L E + + S ++A A+ + + ++V GS + Sbjct: 361 DADFTFTTFDFFRAASERELYEQALVPHKRMSISWSEAIKDAVGNINDNEIIIVSGSLYF 420 Query: 407 VAHVMEVIDARRS 419 V+ V + + Sbjct: 421 VSDVRRWLKESPA 433 >UniRef50_Q3IF42 Bifunctional: folylpolyglutamate synthase; dihydrofolate synthase n=3 Tax=Alteromonadales RepID=Q3IF42_PSEHT Length = 421 Score = 437 bits (1125), Expect = e-121, Method: Composition-based stats. Identities = 180/422 (42%), Positives = 254/422 (60%), Gaps = 8/422 (1%) Query: 2 IIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 + K P +S L WL YLE++H + I +GLERV+ VA +G+L + + +AGTNGKG Sbjct: 1 MTKTIPSQSSSLDDWLFYLESVHPENIAMGLERVASVANNIGLLNTSSKIILIAGTNGKG 60 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL 121 TT R LES+L+A G VG Y+SPHL Y ERVRV GQEL + H +F +E R D +L Sbjct: 61 TTARCLESLLLAQGLSVGTYASPHLTHYNERVRVNGQELSDQYHVDAFHLLEQGRKDTAL 120 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 TYFEYGTL+AL +FK+ ++D V+LEVGLGGR DATNIV +V+T+I LDH ++LG R Sbjct: 121 TYFEYGTLAALAIFKRCEVDYVLLEVGLGGRYDATNIVTPFASVITTIDLDHKEYLGDTR 180 Query: 182 ESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 E + +KAGIFR PAI+G+ +P T+ D E A + G ++ + +++ Sbjct: 181 ELVAYDKAGIFRENTPAIIGDLNIPHTMTDYGDEINAKMVLSGSDFIFKEHADTFSWQYQ 240 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 LE L P +P NAATAL L L SE+ I+ +A+ ++ GRF+ +S+ P V Sbjct: 241 QYNLE-LAKPAIPSQNAATALTTLSVLNLLPSESVIKACLANLVVEGRFEQLSDQPLVYT 299 Query: 302 DVAHNPHAAEYLTGRMKAL-PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHNP +A YL ++ + K ++ A++ ML DKD AG L + +VD W A L GP Sbjct: 300 DVAHNPESARYLASKLLSYKDKGFKIHALVAMLADKDKAGVLKEVSHLVDQWSLASLNGP 359 Query: 361 RGATAEQLLEHLGNG------KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 RG +A L L + S++SVA A D + + + ++V GSF TVA ++ Sbjct: 360 RGDSASNLQNALQSIPHNDIKHSYNSVAAALDVILPTQQNDTVLIVFGSFFTVAGAIDYF 419 Query: 415 DA 416 Sbjct: 420 KK 421 >UniRef50_Q2JLQ4 Folylpolyglutamate synthase n=2 Tax=Synechococcus RepID=Q2JLQ4_SYNJB Length = 433 Score = 437 bits (1124), Expect = e-121, Method: Composition-based stats. Identities = 136/419 (32%), Positives = 205/419 (48%), Gaps = 27/419 (6%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 W ++LE+L +DL LER+ ++ RLG + VAGTNGKG+ C + +L AA Sbjct: 12 DWPAFLESLGHFGVDLSLERMQVLLQRLGQPQAGIPAIHVAGTNGKGSVCAWVSHVLWAA 71 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-----ARGDISLTYFEYGTL 129 GY+VG Y+SPHLV + ER+ + G+ + + + + A++ A + S T FE T Sbjct: 72 GYRVGRYTSPHLVDWRERIWLNGEYISANDWSQALAQVRDCLQTYAPDEASPTQFEVITA 131 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNI-VDADVAVVTSIALDHTDWLGPDRESIGREK 188 +A F++ ++DV ++EVGLGGRLDATN ++ V +TSI DH LG I EK Sbjct: 132 AAWLYFRRQKVDVAVIEVGLGGRLDATNAGIEPVVTAITSIGWDHWQRLGNSLPQIASEK 191 Query: 189 AGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 AGI + PA+ PE+ + I A++ + L+ W G L Sbjct: 192 AGILKPGIPAVCAPQTPEVTAVIRAKAEQLRSPLRVVDPLQWSEPQTVHW-----RGQLL 246 Query: 247 NLPL-PLVPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIF 301 LPL V NAA ALA L+ G +++ A+ G A PGR Q V S +++ Sbjct: 247 TLPLSGDVQLTNAAVALAVVETLQQQGWRIADAAVEKGFAITRWPGRLQRVQIGSRQLLM 306 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D AHN AA+ L + + +G+L KD+ G L+ L D ++ P+ G Sbjct: 307 DGAHNLPAAQALRRYLDEHQPG-PLTWYVGILTTKDVQGILSTLLRPGDCFFALPIAGHS 365 Query: 362 GATAEQLLEHLGNGKSF-DSVAQ-----AWDAAMADAKA--EDTVLVCGSFHTVAHVME 412 G EQL + + S + A A + K E ++CGS + + VM+ Sbjct: 366 GTDPEQLAQLAQTLQPHLASARELPNLSALRAQLLKPKNLTELPAVICGSLYLLGQVMQ 424 >UniRef50_Q492H5 Folylpolyglutamate synthase n=3 Tax=Enterobacteriaceae RepID=Q492H5_BLOPB Length = 424 Score = 437 bits (1124), Expect = e-121, Method: Composition-based stats. Identities = 206/417 (49%), Positives = 277/417 (66%), Gaps = 7/417 (1%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 I TP S L WL+Y+E+L IDL L+RV +A LG++ PA +V V GTNGKGT Sbjct: 4 IFHTPPERSSLGKWLNYIESLSHVLIDLNLDRVRKIAINLGLMHPAEYVILVGGTNGKGT 63 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 TC LE+IL+ VG+Y+SPHL+ Y ER+RV G+ELP+S H + + IES R I+LT Sbjct: 64 TCCLLETILLNNNNTVGLYTSPHLLSYNERIRVCGKELPDSIHIEALSVIESVRHHIALT 123 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+ TLSAL++FK+A+LDVVILEVGLGGRLDATNIV+ D++V+T+ A+DHTD+LG +R+ Sbjct: 124 YFEFITLSALYIFKRAKLDVVILEVGLGGRLDATNIVNPDISVITNFAIDHTDFLGINRD 183 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 I +EK+GIFR KPA++GE P +AQ GA+L RG +WN+ V + W + + Sbjct: 184 MIAQEKSGIFRFNKPAVIGESCFPVIARKMAQYCGAMLFARGRDWNFRVYGNKWIWWECS 243 Query: 243 GTLE---NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 + +LPLP++P NAATAL+ L V + AI G+ A LPGRFQIV+ P Sbjct: 244 NEYKLLYDLPLPIIPIENAATALSVLYWLPFLVDKTAISYGLQVATLPGRFQIVTRRPIA 303 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNG--RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 I DV HNPHAA YLT R+ L K +V VIGML +KDI GT+ L +VD WYC+ L Sbjct: 304 ILDVGHNPHAANYLTKRLPVLLKRRTGKVRMVIGMLKNKDIQGTIYCLSHLVDVWYCSDL 363 Query: 358 EGPRGATAEQLLEHL--GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 P A++ +L + L N + F ++ AW+ A+ DA +D +LV GSFH V+ +M Sbjct: 364 NVPFSASSVELSDCLLHCNVQIFSNILDAWNQAVLDASFDDCILVFGSFHAVSPIMR 420 >UniRef50_Q1D8V1 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Cystobacterineae RepID=Q1D8V1_MYXXD Length = 410 Score = 437 bits (1124), Expect = e-121, Method: Composition-based stats. Identities = 137/398 (34%), Positives = 196/398 (49%), Gaps = 16/398 (4%) Query: 33 ERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTER 92 ERV A LG + VAGTNGKG+TC + L AAG++VG+Y+SPHLVR ER Sbjct: 2 ERVQEALAALGHPERRYPALHVAGTNGKGSTCAMTAASLHAAGHRVGLYTSPHLVRVNER 61 Query: 93 VRVQGQELPESAH-TASFAEIE--SARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGL 149 +RV +++ ++ +E + +TYFE+GT+ ALW F Q ++DV +LE GL Sbjct: 62 IRVDSEDISDADFGLRILEVLERYPSAVSSPMTYFEFGTVVALWHFAQVRVDVAVLETGL 121 Query: 150 GGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PEMPS 207 GGRLDAT V +T ++ DH ++LG +I EKAGI + P +V PE Sbjct: 122 GGRLDATTAASPVVTAITPVSFDHMEYLGDTLAAIAGEKAGILKPGVPCVVARQAPEALE 181 Query: 208 TIADVAQEKGALLQRRGVEWNYSVT-DHDWAFSDAHGTLENLPLPL---VPQPNAATALA 263 I A++ GA ++ G ++ D ++ A +L+ L + L + NAA ALA Sbjct: 182 AILRKAEQVGAPVRLEGRDFTGERQPDGGLSYRGATWSLDGLSVALRGPHQRQNAAVALA 241 Query: 264 ---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKAL 320 AL+ G+ A R G+ASA PGR + V + P ++ D AHNP E L +K L Sbjct: 242 CLEALQERGVTAPPEAARAGLASACWPGRLEEVGQQPILLLDGAHNPAGVEVLLASLKDL 301 Query: 321 PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE----QLLEHLGNGK 376 R+ V G++ DKD + L PLE PR E + + Sbjct: 302 YPGRRLHLVFGVVGDKDRGPMMRALLPECASVQLTPLETPRSLAPEAYLAEARALCADVT 361 Query: 377 SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 ++ A AA A A D VL GS V + + Sbjct: 362 AWPDADAALAAARKRAAANDLVLCTGSLFLVGMMKARM 399 >UniRef50_A1SW71 FolC bifunctional protein n=2 Tax=Psychromonas RepID=A1SW71_PSYIN Length = 428 Score = 436 bits (1122), Expect = e-121, Method: Composition-based stats. Identities = 188/426 (44%), Positives = 266/426 (62%), Gaps = 17/426 (3%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 +I ++ PQ L WL+Y+E LH IDLGL R++ VA+ L V+ V TVAGTNGK Sbjct: 4 VIPQKLPQ---TLPQWLAYIEILHPSAIDLGLSRIAKVASALQVINFDAQVITVAGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 GTTC LE IL+ AG+KVGVYSSPH+ RYTER+R+ QEL + AH +F+ IE R + S Sbjct: 61 GTTCAFLEEILLQAGFKVGVYSSPHIQRYTERLRINKQELSDQAHCDAFSAIEKIRKETS 120 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 L+YFEY TL L L KQA D ++LEVGLGGRLDATN+V++D +V+T+I +DH DWLG D Sbjct: 121 LSYFEYATLGCLSLLKQAHCDYILLEVGLGGRLDATNVVESDASVITTIDIDHIDWLGSD 180 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD 240 RE IG EKAG+FR+ KP I GE + P ++ AQ ++ G +++Y VT W +S Sbjct: 181 REKIGFEKAGVFRANKPVICGEFDPPLSLQAHAQNLNCQIKYAGKDFSYQVTGKQWNWSG 240 Query: 241 AHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSES--PR 298 TL+++ LPL+P NA+TALA + A ++V+ +++ I +A L GR Q +S + Sbjct: 241 KQ-TLKDIRLPLLPVQNASTALAVIEALQVKVNPAVLKNAIENASLAGRLQKISTTSVCD 299 Query: 299 VIFDVAHNPHAAEYLTGRMK----ALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 V DVAHNP +A YL +++ P+ +V A++GML DKDI GT + + +D Sbjct: 300 VYLDVAHNPQSAGYLASQLRLIKAEKPEKCKVHAIVGMLADKDITGTFDQINTEIDFCNL 359 Query: 355 APLEGPRGATAEQLLE-------HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 L+ RG +A+ LLE L F++V A++ + D +++ GSFHTV Sbjct: 360 VSLDCYRGLSADSLLENHQKSKNALTTPICFENVNLAYETVRNKVDSSDIIIIFGSFHTV 419 Query: 408 AHVMEV 413 + + Sbjct: 420 SDFLNF 425 >UniRef50_B4CZE0 FolC bifunctional protein n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4CZE0_9BACT Length = 408 Score = 436 bits (1122), Expect = e-121, Method: Composition-based stats. Identities = 129/423 (30%), Positives = 192/423 (45%), Gaps = 33/423 (7%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVL---KPAPFVFTVAGTNGKGTTCRTLES 69 + +L I LGLE + + L + AP +AGTNGKG+ C L++ Sbjct: 3 YGEAVDWLYASQLHGIKLGLENIQRLVETLKIDVAGPRAPKFLHIAGTNGKGSVCAMLDA 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYG 127 AAG + G+++SPHL+ + ER+R+ G+ + E+ +I + D T+FE Sbjct: 63 CCRAAGLRTGLFTSPHLITFRERIRLDGEMISEAEVAEGLTKIRTLAENWDHEPTFFEIT 122 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T AL F+ ++V+LE G+GGRLDATN+V V+T I LDH WLG +I RE Sbjct: 123 TALALAWFQAKGAEIVVLETGMGGRLDATNVVSPVACVLTPIDLDHQQWLGESLGAIARE 182 Query: 188 KAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 KAGI + PA+ E+ + A+VA EK L+ Sbjct: 183 KAGILKQGVPAVSAPQADEVGAVFAEVATEKQVALEYIP---------------TPLAGY 227 Query: 246 ENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 E NAA A+ AL +GL VSE AI G+ PGRFQ V R I D AH Sbjct: 228 EVALAGSHQMWNAALAVRALSLAGLPVSEEAIVRGLREVSWPGRFQHVQS--RFIIDGAH 285 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATA 365 NP AA L + + + R ++G+L DKD+ G L + P+ PR AT+ Sbjct: 286 NPAAARRLATTWREVFGDKRASLILGVLRDKDVNGICEALLPIAGRILTVPVNNPRSATS 345 Query: 366 EQLLEHLG------NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 ++ +G + A A + + L+ GS + ++A+ + Sbjct: 346 MEVARAIGKIAPRLECIVVRDLPAAIRIAQSMERKT---LITGSLFLAGEALAFLEAQPA 402 Query: 420 GGK 422 + Sbjct: 403 PEQ 405 >UniRef50_B2A1F3 FolC bifunctional protein n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A1F3_NATTJ Length = 465 Score = 435 bits (1121), Expect = e-120, Method: Composition-based stats. Identities = 124/455 (27%), Positives = 200/455 (43%), Gaps = 53/455 (11%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 + +++NL GLER++ + L V VAGTNGKG+TC LES+L + Sbjct: 6 DEAIKWIQNLDKFGSKPGLERINWLLTELNHPHNHYPVIHVAGTNGKGSTCSILESLLSS 65 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD------ISLTYFEYG 127 GY+VG+++SP + + ERV + + ++ EI+ T FE Sbjct: 66 MGYQVGLFTSPFIDDFAERVTCNSKPITKTELGELVCEIKPIVEAAEAKGLGHPTQFEVI 125 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T AL F++ D+VILE GLGGRLDATN+V ++++TSI DH + LG I E Sbjct: 126 TALALLYFQKKSPDMVILETGLGGRLDATNVVTPVLSIITSIGYDHINVLGNTLTKIAEE 185 Query: 188 KAGIFRSEKPAIVG------------EPEMPSTIADVAQEKGALLQRRGVEWNYSVT--- 232 KAGI + P I G + + S I + Q+KG+ L WNY + Sbjct: 186 KAGIIKENIPVITGLHQDKASIEEDTQEQAFSVIEEKCQKKGSPLYASERNWNYRIKAFS 245 Query: 233 --DHDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGL-------EVSENAIRDGIAS 283 + + + NL LPL+ + A AL A L E+ N +R G+ Sbjct: 246 STGYCFDYFGLEAEFINLKLPLLGESQIKNASMALCALELLKKQGWNEIDWNDMRKGMVR 305 Query: 284 AILPGRFQ--------------IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNG---RV 326 +P R + + P V+ D +HNP + + L ++ L N ++ Sbjct: 306 VNIPARMEFWPADSGEKTITGSRAEKQPDVLLDASHNPPSVQNLMSCIRRLDTNRKWNKI 365 Query: 327 LAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL------GNGKSFDS 380 + V G+L DK + +A + D+ + R +A LL+++ N Sbjct: 366 VFVTGVLQDKPMEKIVANFSLIPDEIVVTEPQNTRALSAHCLLDYITDQLPDTNISVESD 425 Query: 381 VAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + +A ++ A +++ GSF+ V + Sbjct: 426 LYKAVRMGISKAGNGSLLVIFGSFYLVVEARRYLK 460 >UniRef50_B2GB02 Folylpolyglutamate synthase n=11 Tax=Lactobacillus RepID=B2GB02_LACF3 Length = 440 Score = 435 bits (1121), Expect = e-120, Method: Composition-based stats. Identities = 106/440 (24%), Positives = 182/440 (41%), Gaps = 32/440 (7%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + + L+++ L+R+ L RLG + + + GTNGKG+T Sbjct: 2 EEITTYDQALAFIHGRTRFKKIPTLKRMRLFLERLGNPQEGLNMIHITGTNGKGSTVAMT 61 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI-------ESARGDIS 120 IL A+G +VG ++SP + RY ER+ + GQ + + T + + + Sbjct: 62 RDILGASGLRVGTFTSPFITRYNERMAIDGQPISDEDLTRIANRVAKVATVLDQELTEGG 121 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGP 179 T FE GT + + D+VILEVG+GG+ D+TN+++ V +T++ DH +LG Sbjct: 122 PTEFEIGTAIMFCYMNEQRPDLVILEVGIGGKWDSTNVIEAPLVTAITTVGYDHMRYLGD 181 Query: 180 DRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-- 235 E I KAGI + P ++G +A VA+ A L G +++ Sbjct: 182 TYEQIASHKAGIIKEGAPLVIGHLPTSAREVVAQVAKAHHAKLYELGTDFDAPNVTPHAL 241 Query: 236 ---WAFSDAHGTLENLPLPLVPQPNAATAL-------AALRASGLEVSENAIRDGIASAI 285 ++S L L A A AL A GL V +R G+ + Sbjct: 242 YPTVSYSGLGLHRAQFKLGLAGDYQVANAAVAITVSQLALAALGLPVLAKDVRRGLEESA 301 Query: 286 LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 P R ++V++ P +I D AHN + L +K + +V + +L DK L L Sbjct: 302 WPARMEVVNDEPLMILDGAHNLPGVQALVQTIKDDFFDRQVYLEVAILADKQYELMLGEL 361 Query: 346 KSVVD-DWYCAPLEGPRG--------ATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAED 396 S+ + GP ++L + + +A+ +D Sbjct: 362 ASLANVHLLVTHFAGPAASRPSADLGLAVKELATRYP-VEYVPNWQLGIARLAQEAQGDD 420 Query: 397 TVLVCGSFHTVAHVMEVIDA 416 +++ GS + V+ V + + Sbjct: 421 VIIITGSLYFVSEVRQFLLD 440 >UniRef50_C0QUQ6 Folylpolyglutamate synthetase n=2 Tax=Aquificales RepID=C0QUQ6_PERMH Length = 406 Score = 435 bits (1121), Expect = e-120, Method: Composition-based stats. Identities = 112/406 (27%), Positives = 189/406 (46%), Gaps = 9/406 (2%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 L L N I LER+ +G + ++GTNGKG+T LES+L G Sbjct: 3 LYRLFNRKVFHIQPDLERIKKALEEIGEPQKEFPSILISGTNGKGSTAVYLESLLRYHGL 62 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFK 136 K G+++SPH++ ER +V + + EIE LTYFE + A F Sbjct: 63 KTGLFTSPHIMEENERWQVNRKSIEVDKLDRYIKEIEDLIKRYDLTYFEASAVIAFRYFL 122 Query: 137 QAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEK 196 +D+ +LEVGLGGR DATN+V +++V+T+++LDHTD LG I REK GI R ++ Sbjct: 123 DENVDIAVLEVGLGGRWDATNVVYPEISVITNVSLDHTDLLGNSLMEIAREKLGITRKDR 182 Query: 197 PAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLVPQP 256 P ++G + I+ + + + + Y + D + + ++ ++ Sbjct: 183 PVVIG-TDQMEIISQAVMKGIKEIYHYPIGFTYQIKDRSMDYIFKGKEIRDIRTSILGDR 241 Query: 257 NAATALAAL-------RASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHA 309 + A AL G++V + ++ I+ + +PGR QI+ E P VI D AHN A Sbjct: 242 QLSNAATALTAFLLYSERKGIKVDDEKVKKAISGSFIPGRMQILKEEPPVIVDGAHNLDA 301 Query: 310 AEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLL 369 +K L +++ V + DKD + ++S D L R T +++ Sbjct: 302 VSKTVEEVKRLYPGRKIITVFSCMKDKDYKSIIHIIRSSSDRVIATKLPFSRSITEDEIS 361 Query: 370 EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + + + A A+ +A ++ VL+ GS + +++ I Sbjct: 362 Q-FKDIDFIPDIDGALKKAIEEADSKSVVLITGSLYLAGEILKKIK 406 >UniRef50_B0MBL9 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=B0MBL9_9FIRM Length = 425 Score = 435 bits (1121), Expect = e-120, Method: Composition-based stats. Identities = 110/422 (26%), Positives = 186/422 (44%), Gaps = 23/422 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + + ++ + LGL+ + + RLG + + +AGTNGKG+T L S+ Sbjct: 3 YQATMEFIGRANKFGSILGLDNIRELLNRLGNPQDRLKIVHIAGTNGKGSTLAFLASVFK 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 GY+ G Y SP Y E+ R+ + + + +I+ ++ T FE Sbjct: 63 EQGYEAGRYVSPASFCYEEKFRINDEIITKEDLCFYMEKIKKTAEEMVRDGKEHPTVFEM 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESIG 185 T + F ++D V+LE GLGGRLDATN++ + V+ SI DHT +LG + I Sbjct: 123 ETALSFLYFLDKKVDAVLLETGLGGRLDATNVIKHPICTVIASIGYDHTQYLGSTIQEIA 182 Query: 186 REKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVE----WNYSVTDHDWAFS 239 EKAGI + PA+ + E I A+EK L + ++ +++ Sbjct: 183 GEKAGILKKGCPAVSYDNTSEAREVIEKAAEEKNVPLIFADTSRVTILSENLEGSVFSYV 242 Query: 240 DAHGT-LENLPLPLVPQPNAATALAALRASGLE-----VSENAIRDGIASAILPGRFQIV 293 A GT N+ + ++ + A AAL + +++IR G A GR Q + Sbjct: 243 CADGTEYRNMEIGMLGEHQIFNAAAALETIQILKKSYIFRQDSIRKGFKKARWDGRLQRI 302 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 S P D AHNP A+ L ++ N +++ ++G+L DKD L + S+ D+ Y Sbjct: 303 SAVPAAFCDGAHNPDGAQKLLQFLQKNFTNKKIIYIMGVLSDKDYPQMLEIMSSMSDEIY 362 Query: 354 CAPLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 EG R + L E S+ + + + +D ++V G+ + Sbjct: 363 TVTPEGDRALPSGVLAEAARPFYRKVTEGGSLGECYQQVKKECGQDDVIVVFGTLSFLKE 422 Query: 410 VM 411 + Sbjct: 423 LR 424 >UniRef50_B0UU80 FolC bifunctional protein n=14 Tax=Pasteurellaceae RepID=B0UU80_HAES2 Length = 443 Score = 435 bits (1120), Expect = e-120, Method: Composition-based stats. Identities = 205/444 (46%), Positives = 281/444 (63%), Gaps = 31/444 (6%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M+ A SPL WL +LE H+K IDLGL+RV VA +L +L+PAPFV TV GTNGK Sbjct: 1 MMSSLNLFATSPLEQWLCFLEKAHAKAIDLGLDRVKTVAQQLDLLQPAPFVITVGGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 GTTCR LE +L+ +G++VGVYSSPHL+RY ERVR+Q QEL + HT +FA IE + S Sbjct: 61 GTTCRLLEILLLNSGFRVGVYSSPHLIRYNERVRIQNQELADEEHTQAFAFIEQHKSQ-S 119 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 LTYFE+ TLSAL+LFKQA LDVVILEVGLGGRLDATNIVDAD+AV+TSI +DHTD+LG Sbjct: 120 LTYFEFSTLSALYLFKQANLDVVILEVGLGGRLDATNIVDADLAVITSIDIDHTDFLGNT 179 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD 240 RE I EK+GIFR KPA++GE +P ++ + ++ ++L R +W +S ++ W + Sbjct: 180 REEIAFEKSGIFRPNKPAVIGENNIPCSLLEQGKKLDSILFCRNKDWKFSKQENGWTWET 239 Query: 241 AHG----TLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIV--- 293 G ++NLP+ +P NAATALA L ++S + I + L GRFQ + Sbjct: 240 IKGNKAIYMDNLPICSIPLANAATALATLAYLPFDISISVIHKSLREVELAGRFQKINPE 299 Query: 294 -------------SESPRVIFDVAHNPHAAEYLTGRMKALPKN--GRVLAVIGMLHDKDI 338 + P++I DV HNPHAA YL R+ AL G++++V G+L DKD Sbjct: 300 KLLNLAKLSKKTVKQLPQIIVDVGHNPHAASYLLERLTALKAKSIGKIISVCGILKDKDS 359 Query: 339 AGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN--------GKSFDSVAQAWDAAMA 390 G L+ L VVD W L+G RG ++ +L L +++ SV + +A+ Sbjct: 360 QGILSPLIKVVDQWNLVTLDGVRGQSSHELFMTLQQISTTNELSAQTYSSVYEGVKSAVQ 419 Query: 391 DAKAEDTVLVCGSFHTVAHVMEVI 414 +A +D +LV GSF+TV ++++ Sbjct: 420 NATEKDIILVFGSFYTVGSFLKLL 443 >UniRef50_A9QPJ9 Folylpolyglutamate synthase n=1 Tax=Methylacidiphilum infernorum V4 RepID=A9QPJ9_METI4 Length = 441 Score = 435 bits (1120), Expect = e-120, Method: Composition-based stats. Identities = 120/426 (28%), Positives = 184/426 (43%), Gaps = 22/426 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L++L + LGL+ V +A +G +AGTNGKG+T + S L Sbjct: 11 YRQALNFLGQARKVGMKLGLQNVQRLAMEMGNPHENLNFIHIAGTNGKGSTAAFIASALQ 70 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASF-------AEIESARGDISLTYFE 125 A+G K G++SSPHLV ER++V G+ + + + +I + D + T+FE Sbjct: 71 ASGLKTGLFSSPHLVTIRERIQVNGKPITKIQFSRWVLEIQGKIQKIRQLKEDFTCTFFE 130 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 ++A+ F ++++D V+ E GLGGRLDATN V ++V+T+I DHT +LG E I Sbjct: 131 IMAIAAILEFSRSKVDWVVWETGLGGRLDATNFVIPRLSVITNIDYDHTQFLGETLEEIA 190 Query: 186 REKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 EKAGI + P +VG + A GA + + D+ Sbjct: 191 AEKAGIIKEGVPVVVGNLSHGALEVVKKCAARVGAPVVEVFRSVSLKSIKLDYKEHWVEI 250 Query: 244 TLENLPLPLVPQPNAATALAALRASGL------EVSENAIRDGIASAILPGRFQIVSESP 297 L L A A + L + +I+ G + PGRFQ++ E P Sbjct: 251 AGFPFCLGLTGYHQLENAACAFVSLKLLFSKEDPLDIKSIQQGFRAVDWPGRFQLLWEKP 310 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 I D AHN A L + + + V G+L DK+ A LK + Sbjct: 311 LCIVDGAHNVGAVVQLVANWEKIFGDEPYHLVFGVLKDKNFALMADVLKRKAQEVTLIKP 370 Query: 358 EGPRGATAEQLLEHLGNGKSFDSVAQAWDAA-MADAKAEDTVLVCGSFHTVAHVMEVIDA 416 RG ++L G+ K V W ++ + +LV GS + + HV+ Sbjct: 371 PTVRGLEPQKLFPFFGDVKL--RVCSCWSDFKLSLDRTSLPILVTGSLYLIGHVL----V 424 Query: 417 RRSGGK 422 GGK Sbjct: 425 EECGGK 430 >UniRef50_C2BDR7 Possible tetrahydrofolate synthase n=2 Tax=Anaerococcus RepID=C2BDR7_9FIRM Length = 424 Score = 435 bits (1120), Expect = e-120, Method: Composition-based stats. Identities = 109/426 (25%), Positives = 190/426 (44%), Gaps = 21/426 (4%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 +L YL S D L + V + VAGTNGKG+T + L + Sbjct: 1 MKNFDDYLDYLYGRGSSGEDHTLRNIRKVMEAFDNPQDKIKTIHVAGTNGKGSTAKMLAN 60 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD-----ISLTYF 124 +L + K G+++SP++VR E + + G ++ I +TYF Sbjct: 61 VL-SKKVKCGIFTSPYMVRINEEISINGVDISNEDFCNLMDRIRPVAEQCDEEGYHITYF 119 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRES 183 E+ T F + ++DV ++EVGLGG LD+TNI+ +V+ SI++DH + LG E Sbjct: 120 EFLTAMVYLYFYEQKVDVAVIEVGLGGSLDSTNIIKSPLASVICSISMDHMNVLGSTIEE 179 Query: 184 IGREKAGIFRSEKPAIVGEP---EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD 240 I KAGI + +P V E I + + + A L + D+ + Sbjct: 180 IAANKAGIIKKNRPVFVYPQTSEEAFRVIKEKSIAEQAQLFTFKKDEINIKDFSDFGNTF 239 Query: 241 AHGTLENLPLPL---VPQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVSE 295 + ++L L NA+ AL L +SE+ I++GI PGR +VS Sbjct: 240 DFKSYKDLQTSLRGEHQIYNASLALMVLDYFKKDFNLSEDDIKEGIRETYNPGRVDLVST 299 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 +PRV+ D +HN + + L +K +++ +L DKD + + + D+ Sbjct: 300 NPRVLLDGSHNKESIDALLASLKK-FDYDKLIVGFSILKDKDHKDIIRKIAGLADELIIT 358 Query: 356 PL-EGPRGATA----EQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 + + PR E+ + + ++ QA++ ++ +AK +D VL CGS + + + Sbjct: 359 HIDDNPRALDTQIIDEEAKAYASDIHVIENNKQAFEFSLKEAKDKDLVLWCGSLYLIGKI 418 Query: 411 MEVIDA 416 + ++ Sbjct: 419 LSYMEK 424 >UniRef50_D1PK55 Tetrahydrofolate synthase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PK55_9FIRM Length = 432 Score = 435 bits (1120), Expect = e-120, Method: Composition-based stats. Identities = 120/426 (28%), Positives = 183/426 (42%), Gaps = 22/426 (5%) Query: 14 ASWLSYLENLHSKTI-DLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + L L GLER+ + A LG + + +AGTNGKG+ +IL Sbjct: 4 QQAMEALHALPRLGSGKPGLERMKNLLAHLGNPEESLQCVHIAGTNGKGSLAAMTAAILT 63 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEY 126 AAGYK G+ SP++V + ER ++ G+ +P + ++ A G FE Sbjct: 64 AAGYKTGLTISPYVVDFRERFQIDGEMIPPRTLASLTQKVLGAIEAIRQEGGEEPVQFEA 123 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDA-DVAVVTSIALDHTDWLGPDRESIG 185 T AL F + + D+V+LE GLGGR DATN V VA +T I DH + LG + I Sbjct: 124 VTALALLWFAREKCDLVVLETGLGGRYDATNAVPHTLVAAITKIGYDHMELLGDTLDKIA 183 Query: 186 REKAGIFRSEKPAIV---GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 EKAGI + + E I A E + +E + + Sbjct: 184 AEKAGIIKEGCAVVCYPDQPAEAMGPILTAAAEAHTSIITPELEDIRQLPGKTLENRIDY 243 Query: 243 GTLEN--LPLPLVPQPNAA----TALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 G + +AA ALA R G E+S++AI G+A+A +P R +++ Sbjct: 244 GGYQASLAFPGAHQANHAAMAVEIALALWREYGYEISDDAILQGLAAARMPARIEVLRRH 303 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P ++ D HNP L ++ ++ V+GML DKD L L Y Sbjct: 304 PLLLLDGCHNPDGTRALAETLQKAKYEENLVGVLGMLADKDYQKMLEILAPCFAKVYTVT 363 Query: 357 LEGPRGATAEQLLEHLG---NGKSFDSVAQAWDAAMADAKAEDT--VLVCGSFHTVAHVM 411 PR + E L + + ++ +V +A AA+ A+ + V+VCGS + A Sbjct: 364 PNCPRALSGEDLQKAARFHMDAEAAATVPEALRAAVRYAEDHNLAGVVVCGSLYLAAEAR 423 Query: 412 EVIDAR 417 + Sbjct: 424 PWLLKE 429 >UniRef50_Q6FEE4 Bifunctional protein n=18 Tax=Acinetobacter RepID=Q6FEE4_ACIAD Length = 428 Score = 435 bits (1119), Expect = e-120, Method: Composition-based stats. Identities = 180/428 (42%), Positives = 254/428 (59%), Gaps = 11/428 (2%) Query: 2 IIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKG 61 + P L +WL+Y ++H IDLGLERV VA +LGV + + VFTVAGTNGKG Sbjct: 1 MKLDAPSIQDDLMTWLTYWGHVHVTGIDLGLERVIPVAEKLGVTQTSAKVFTVAGTNGKG 60 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD--I 119 +T TL SIL GY+VG+Y SPH+ R+ ERV++ GQE + +F +++ R + + Sbjct: 61 STTTTLASILTEQGYRVGLYQSPHIYRFNERVKLNGQEASDQQLIEAFVKVDQVRRECGL 120 Query: 120 SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGP 179 SL++FE TL+A +F+Q D+ +LEVGLGGRLD N++D DVAV+T+I LDHTDWLG Sbjct: 121 SLSFFEATTLAAFLIFQQQACDIWVLEVGLGGRLDVVNVIDPDVAVITNIGLDHTDWLGD 180 Query: 180 DRESIGREKAGIFRSEKPAIVGE-PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF 238 E I EKAGI RS P I G +P IAD A + A L G ++ Y V ++ Sbjct: 181 TIEKIAFEKAGIIRSNIPVIFGGVQTLPQAIADKAAAQQAQLYVLGRDYFYQVAPDQKSW 240 Query: 239 SDA-HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRF-QIVSES 296 + A GT LPL + N +TA+AAL SG++VS+ AI GI A L GRF Q + ++ Sbjct: 241 NFASSGTTLKLPLGSLALENISTAVAALLVSGIDVSQAAITSGIEKAHLAGRFEQRIIKN 300 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGR----VLAVIGMLHDKDIAGTLAWLKSVVDDW 352 V+FD HN H ++L +++ + + V+AV ML DKDI + LK V W Sbjct: 301 KAVVFDAGHNGHGVDFLLKQLRNFLEYNKQYTEVIAVFSMLADKDIKAVVNLLKPAVLHW 360 Query: 353 YCAPLEGPRGATAEQLLEHLGN--GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 A L PR A QLL+ L + +DS+ +A+ A+ +++ +LVCGSFHT+ V Sbjct: 361 KVAALSVPRAAPVTQLLDALDGEITQQYDSIREAFSVALEESRPHQLILVCGSFHTLEAV 420 Query: 411 MEVIDARR 418 E ++ + Sbjct: 421 WEYLEKCQ 428 >UniRef50_Q67SJ1 Folylpolyglutamate synthase n=1 Tax=Symbiobacterium thermophilum RepID=Q67SJ1_SYMTH Length = 437 Score = 434 bits (1118), Expect = e-120, Method: Composition-based stats. Identities = 141/425 (33%), Positives = 204/425 (48%), Gaps = 21/425 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNGKGTTCRTLES 69 + L+YL L + GLER + +LG V + GT+GKG+ +E+ Sbjct: 1 MTYEAALAYLAGLQRFGMKPGLERTVALLEQLGRPDRRVGRVVHITGTSGKGSVAAMVEA 60 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTAS------FAEIESARGDISLTY 123 L AAG +VG+Y+SP L+R+ ER++V E+PE+ AE A G T Sbjct: 61 GLRAAGRRVGLYTSPPLMRFKERMQVNRAEIPEADVARLTARVAEAAEAVIAAGLEPPTE 120 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRE 182 FE T AL F + +D ++LE G+GGR DAT V+ A V +T++ LDHT WLG E Sbjct: 121 FEVITAMALAWFAEQSVDDLVLEAGMGGRFDATTAVEKAAVTAITNVGLDHTQWLGQTHE 180 Query: 183 SIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGAL-LQRRGVEWNY---SVTDHDW 236 +I +KAG+ R P + G P + I VA+E+GA L ++ ++ Sbjct: 181 AIAWDKAGVIRPGVPCVTGTDHPGALAVIERVAREQGAPLLHVTPADFRVLGADLSGQVA 240 Query: 237 AFSDAHGTLENLPLPLVPQPNAATALAALRASG-LEVSENAIRDGIASAILPGRFQIVS- 294 G + L L+ + AA A ALR L V E AIR+G A PGR +++ Sbjct: 241 DLRGERGWYRRVRLSLLGRHQAANAAVALRILEVLGVDEGAIREGFAHVAWPGRMELLRA 300 Query: 295 -ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 V+ D AHNP L G + L RV V+GML DKD A LA L + + + Sbjct: 301 AGGQLVLLDAAHNPAKCAALAGAVAELFPGRRVHLVVGMLADKDAAQGLAPLLPLAERVW 360 Query: 354 CAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 E PR A +L + + +A +AA+A A D V++ GSF+TV Sbjct: 361 ATTPESPRAMPAPELAQLCRELGHPALVAADLPEALEAALAAAAPGDLVVITGSFYTVGP 420 Query: 410 VMEVI 414 ++ Sbjct: 421 ARRIL 425 >UniRef50_B5JSE1 FolC bifunctional protein n=1 Tax=gamma proteobacterium HTCC5015 RepID=B5JSE1_9GAMM Length = 427 Score = 434 bits (1117), Expect = e-120, Method: Composition-based stats. Identities = 176/416 (42%), Positives = 247/416 (59%), Gaps = 15/416 (3%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 L +WLS+ LHS +DLGL+R+ V ARL + V TVAGTNGKG+T LES Sbjct: 5 FDSLQAWLSWQGRLHSSEVDLGLDRIRAVLARLSLDFSQSIVVTVAGTNGKGSTLAFLES 64 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 I AGY+VG+++SPH + Y ER+R+ G + E A +FA I+S RG+ISLTYFE+ TL Sbjct: 65 IYRQAGYRVGLFTSPHFLHYCERIRIDGDRVSEQAVCDAFAAIDSVRGEISLTYFEFSTL 124 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +ALWLF + L V++LEVGLGGRLDA+N++DADV +VTS+++DH DWLG +RE IGREKA Sbjct: 125 AALWLFARESLAVILLEVGLGGRLDASNVIDADVGIVTSVSIDHRDWLGDNREDIGREKA 184 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 GI+R + AI G+P P ++ +VA KG+ Q RG ++ + D A E+ Sbjct: 185 GIYRRNRMAISGDPHPPHSLREVASIKGSDWQGRGEQFEVFTSSEDRARWRLQWRGEDFE 244 Query: 250 LPL-------VPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSESPRVI 300 P + NAA+AL A+ V ++ + G+ A LPGR Q++ ++P V+ Sbjct: 245 FPYPERLTAPIQLDNAASALVAVLGLRAQRPVDKSDMDRGLCQAGLPGRLQVIGQNPEVM 304 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DVAHN AA+ L G + +V V+GML DK++ T + L+++ WY A + Sbjct: 305 LDVAHNEAAAKALFGAVAGR-SYEQVHLVLGMLQDKEVRATASVLEALQPHWYLATPQSE 363 Query: 361 RGATAEQLLE-----HLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 R +L + SV +A+ AA+ A D V+V GSF TVA VM Sbjct: 364 RAMDCRELAAMLPGSAASASVCYASVTEAYRAALGRAGENDLVIVTGSFFTVAEVM 419 >UniRef50_C5SCQ4 FolC bifunctional protein n=1 Tax=Allochromatium vinosum DSM 180 RepID=C5SCQ4_CHRVI Length = 432 Score = 433 bits (1115), Expect = e-120, Method: Composition-based stats. Identities = 188/428 (43%), Positives = 253/428 (59%), Gaps = 16/428 (3%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA---PFVFTVAGT 57 M + + L WL + +LH +DLGLERV V ARL + V TV GT Sbjct: 1 MTLTTDMARFATLDDWLDWQSSLHPSRMDLGLERVGAVWARL-APERGRLPCPVITVGGT 59 Query: 58 NGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG 117 NGKG+T +ES+ +AAGY+ GVY+SPHL RY ERVR+ G + + A SF I+ AR Sbjct: 60 NGKGSTVAMIESMALAAGYRCGVYTSPHLCRYNERVRLDGVPVADEALCDSFERIDRARE 119 Query: 118 DISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWL 177 ISLTYFE+GTL+AL +F +A+ D+V+LEVGLGGRLDA N++D+DV+VVTSI LDHTDWL Sbjct: 120 GISLTYFEFGTLAALDIFARARPDLVVLEVGLGGRLDAVNLIDSDVSVVTSIGLDHTDWL 179 Query: 178 GPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWA 237 G ESI REKAGIFR +PAI+G+ + P T+ A GAL + G E +++ T W Sbjct: 180 GDSLESIAREKAGIFRPGRPAIIGQRDAPETLRAEAARIGALALQLGRELDHARTTEGWI 239 Query: 238 FSDAHGTLENLPLPLV----PQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQ 291 ++ G LP+P + NA A+AA++A L V NAIR G+ A LPGRFQ Sbjct: 240 WTGPDGQRLALPIPALRGSFQLDNATAAIAAVQALRERLPVPVNAIRAGLQRARLPGRFQ 299 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 ++ + I DVAHN AAE L ++ GR+ AV+ +L DK+ + ++ V+D Sbjct: 300 VMPGAVTWILDVAHNGEAAEALAANLRDFACPGRLRAVLAVLADKNPERLVTPIREYVND 359 Query: 352 WYCAPLEGPRGATAEQLLEHLG------NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 WY A E R EQL L +F VA+A AA+A++ D +L+ GSF Sbjct: 360 WYLAQSEDARALPVEQLSARLDGLIGANRRGAFGCVAEAIGAALAESAPGDALLIVGSFT 419 Query: 406 TVAHVMEV 413 TV + Sbjct: 420 TVGQALRH 427 >UniRef50_UPI0001745D4D FolC bifunctional protein n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI0001745D4D Length = 413 Score = 433 bits (1115), Expect = e-120, Method: Composition-based stats. Identities = 123/415 (29%), Positives = 181/415 (43%), Gaps = 30/415 (7%) Query: 16 WLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAG 75 L +L I LGLE + + + VAGTNGKG+ C L S+L AA Sbjct: 11 ALDWLYGTQLFGIKLGLENTRKLLDDMKLPMGGQKFLHVAGTNGKGSVCAFLHSLLKAAE 70 Query: 76 YKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSALW 133 G+++SPHL+ + ER+R + + + D T+FE AL Sbjct: 71 VNAGLFTSPHLIHFRERIRDAERTITSQEIVKEVDALRKRVEGWDPHPTFFELTFALALD 130 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F++ +L+ V+LE G+GGRLDATN V V+TSI+LDH LG I EKAGI + Sbjct: 131 WFRKQELEWVVLETGMGGRLDATNTVLPAACVITSISLDHQQHLGATLREIATEKAGIIK 190 Query: 194 SEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLP 251 P I PE+ ++D A+E+GA L + + Sbjct: 191 PGVPVITLKQAPEVMQVLSDTARERGAPLSIV---------------TTPLRGYQLGLFG 235 Query: 252 LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAE 311 NA A+AA +A+G SE +R G+ + P RFQ + R+I D AHNP AAE Sbjct: 236 QHQLWNATLAVAAFKAAGFRASEPVLRVGLKTVEWPARFQREEQD-RLIIDGAHNPDAAE 294 Query: 312 YLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEH 371 L + V G + +KD + L+ + W+ + PR E L + Sbjct: 295 TLVRTWHQAFPGEKASVVFGAVSNKDAKAVMRSLQPIASHWHFTRFDSPRAMAPEDLRKE 354 Query: 372 LG-------NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRS 419 L N +++ A A +A+ VLV GS + V+ ++ R Sbjct: 355 LADLYASAVNCSVHETIEDALAKARHNAE---RVLVTGSLYLAGEVISILRGERE 406 >UniRef50_B3QVA8 FolC bifunctional protein n=1 Tax=Chloroherpeton thalassium ATCC 35110 RepID=B3QVA8_CHLT3 Length = 432 Score = 433 bits (1114), Expect = e-120, Method: Composition-based stats. Identities = 123/421 (29%), Positives = 195/421 (46%), Gaps = 18/421 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNGKGTTCRTLESIL 71 + +L L LGLE + + LG + + VAGTNGKG+ SI Sbjct: 3 YQETIEFLFPLRRFGQKLGLENIQALCDALGNPERNLGTIVHVAGTNGKGSVSAMTASIC 62 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 G KVG+YSSPHL +TER+++ G +P+ +I+ IS T+FE T A Sbjct: 63 KEMGKKVGLYSSPHLACFTERIKINGMSIPKEKVAEYCTQIKEIVPRISSTFFEVTTALA 122 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 F + ++DV ++E G+GGRLDATN++ + +V+T++ L+HT+WLG +E I EKA I Sbjct: 123 FKYFAEEKVDVSVIETGIGGRLDATNVIPSSYSVITNVELEHTEWLGETKEKIAVEKADI 182 Query: 192 FRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWA-----FSDAHGT 244 R + + I A+++ A ++ +Y + + T Sbjct: 183 IRPKSSVFTAAKDLDALEVITRTARDRKAKIRIASALSDYQIISQEIGLLSVHLRTKRRT 242 Query: 245 LENLPLPLVPQPNAATA-LAALRASGLEVSENAIRDGIASAI----LPGRFQIVSESPRV 299 L +P A A LA L A + E IR+G+A+ R + V E P V Sbjct: 243 YHGLKVPFSGSYQAENAQLAILLAEEMGADELQIRNGLANVHQNTGHRARLERVQEKPVV 302 Query: 300 IFDVAHNPHAAEYLTGRMKALPKN-GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 + DV+HNP + + KN RV V L +KD+A +A LK+ D + + L+ Sbjct: 303 LLDVSHNPPGMQATVKTISHYRKNYARVAVVFAALQEKDVASMVAALKNGCDKIFVSELK 362 Query: 359 GPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 + A ++ + + F + A AA A + VL+ GSF+ V+ + Sbjct: 363 IEKALPATEIHQICEAQDVRAEVFPNPMDAIAAAKAFVGEDGLVLITGSFYLAGEVLAFL 422 Query: 415 D 415 + Sbjct: 423 E 423 >UniRef50_C0CJ78 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0CJ78_9FIRM Length = 433 Score = 432 bits (1113), Expect = e-120, Method: Composition-based stats. Identities = 115/426 (26%), Positives = 181/426 (42%), Gaps = 23/426 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 +Y++ + LGLE + + +LG + V VAGTNGKG+T L +IL Sbjct: 3 YKQSRAYIDQVECYGRVLGLENIEELTQKLGNPQEDLNVIHVAGTNGKGSTIAYLSTILQ 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR------GDISLTYFEY 126 AGYKVG Y SP + Y ER+ + +++ + A ++ + G T FE Sbjct: 63 EAGYKVGKYISPTIYSYRERMSIGEKKISKEAFARHLTKVAAVAEEMAAQGRPHPTPFEI 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDA-DVAVVTSIALDHTDWLGPDRESIG 185 T A F++ + D V+LE G+GG DATN+V +AV+T I LDH +LG I Sbjct: 123 ETAVAFLFFREEKCDFVVLETGMGGATDATNVVRNTRMAVLTPIGLDHMSFLGNTLSEIA 182 Query: 186 REKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRG----VEWNYSVTDHDWAFS 239 KAGI + + E I Q+K + L S + + Sbjct: 183 AVKAGIIKEGCVTVCSCQKAEAREVIEQECQKKHSELIWVDTKTLKVKETSCFGQTFQWE 242 Query: 240 DAHGTLENLPLPLVPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVSES 296 + E + NA AL A LR G E+ + A+ G+++ GRF ++ +S Sbjct: 243 GEN--YEVSLAGVYQIDNAVLALTAVTQLRKMGYEIPKEAVSRGLSNTRWGGRFTVIGQS 300 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA- 355 P + D AHNP AA L + + + ++GM DKD L + Sbjct: 301 PLFVVDGAHNPDAARRLEESICQYFSHKNIYYIVGMFRDKDYDEVLRITAPYAKGIFTVQ 360 Query: 356 PLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 R +A +L E G ++ + +A A A +D ++ GS + + Sbjct: 361 TPNSQRALSARELAEDAGKYHDRVEAVSDLTEAVKRAYEVAGPQDVIVAFGSLSYLGEIT 420 Query: 412 EVIDAR 417 ++ R Sbjct: 421 RIVRER 426 >UniRef50_C6VI65 Folylpolyglutamate synthase n=8 Tax=Bacilli RepID=C6VI65_LACPJ Length = 444 Score = 432 bits (1113), Expect = e-119, Method: Composition-based stats. Identities = 113/436 (25%), Positives = 186/436 (42%), Gaps = 29/436 (6%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 ++ L+++ L R+ LG + VAGTNGKG+T L Sbjct: 2 IDTYSAALAFIHGRTQFKKAPTLSRMRQFLHELGDPQLKVAGIHVAGTNGKGSTVANLRE 61 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LT 122 + MA G VG ++SP +VR+ ER+ V G + + +I+ + T Sbjct: 62 LFMADGLTVGTFTSPFIVRFNERISVDGTPISDEELVGLVQQIQPIVAKLDATLASGGPT 121 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 FE T F +D+ I+EVGLGG D+TN+ V+V+T+I DH LG Sbjct: 122 EFEIITAMMFLYFAAQPIDIAIIEVGLGGLYDSTNVWTPAVSVITTIGYDHMQILGNTLT 181 Query: 183 SIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-----HD 235 +I +KAGI +++ P IVG E + D A K A L+ GV++ + Sbjct: 182 AIATQKAGIIKTQVPVIVGKLPAEAQQVMIDTAMSKRAPLRTLGVDFTTKLLPPQGWQER 241 Query: 236 WAFSDAHGTLENLPLPL---VPQPNAATALAAL----RASGLEVSENAIRDGIASAILPG 288 + F ++L PL NAA A+AA +A+ L V + ++ +A+ PG Sbjct: 242 FNFDGLEAHFKDLTTPLLGDYQVDNAAVAIAAYLTYHQATQLPVVTSDVKAAVAATQWPG 301 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 RF+ +++ P ++ D AHN A L + V + +L DK + L ++ Sbjct: 302 RFERLNQDPLIMIDGAHNEPAVTELAATLSERFGQQTVYVIFAVLADKQHQQMIQTLGAL 361 Query: 349 VD-DWYCAPLEGPRGATAEQ----LLEHLGN---GKSFDSVAQAWDAAMADAKAEDTVLV 400 + EGP L + N + FD+ A + + ++D +L+ Sbjct: 362 PNVQLRLTQFEGPNAKRPATDPTMLAHEMPNGRTAEVFDNWQAALMQTLQEMSSDDALLL 421 Query: 401 CGSFHTVAHVMEVIDA 416 GS + ++ V Sbjct: 422 TGSLYFISDVRAYFKD 437 >UniRef50_C6Y3V5 FolC bifunctional protein n=4 Tax=Sphingobacteriales RepID=C6Y3V5_PEDHD Length = 428 Score = 432 bits (1112), Expect = e-119, Method: Composition-based stats. Identities = 123/428 (28%), Positives = 194/428 (45%), Gaps = 31/428 (7%) Query: 13 LASWLSYLENLHS-------KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 + YL + L L+ A+L + V GTNGKG+T Sbjct: 3 YKQTIDYLYSRLPMFTRVGAVAFKKDLHNTILMCAQLDNPQNKFKTIHVGGTNGKGSTSH 62 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 TL +I AGYK G+Y+SPHL + ER+R+ G +PE+ T + IS ++FE Sbjct: 63 TLAAIFQQAGYKTGLYTSPHLKDFRERIRINGTMVPETFVTDFVNRQKETIEAISPSFFE 122 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 A F + ++D+ I+EVGLGGRLD+TNI+ +++V+T+I+LDHT+ LG I Sbjct: 123 VTVAMAFAYFAEEKVDIAIIEVGLGGRLDSTNIITPELSVITNISLDHTNMLGNTLTEIA 182 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVE------WNYSVTDHDWA 237 EKAGI + P ++G + E + A + + E + Sbjct: 183 TEKAGIIKPGIPVVIGEKQTESEAVFLTKASTTNSKIVFADQELSTTNTFREKEYLVTSI 242 Query: 238 FSDAHGTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAI----LP 287 + ++L L L A+ L+ G +++ A+ + + L Sbjct: 243 LKNKILIYKDLQLDLNGIYQLKNILTVLQAVDILKNKGYTLNDKALYTALKNVKTLTGLQ 302 Query: 288 GRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS 347 GR+Q +SE P VI D HN + + +K ++ VIGM+ DKDI+G L L Sbjct: 303 GRWQKLSEHPLVICDTGHNMAGIKEVVQNLKE-TPFEKLHIVIGMVKDKDISGVLT-LLP 360 Query: 348 VVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 +Y + R A++L +G FD+V A +AA +A +D + + GS Sbjct: 361 TEAIYYFCQPQLERALPAQELALQAKVQQLHGNVFDTVTAALNAAKENAGKDDLIFIGGS 420 Query: 404 FHTVAHVM 411 VA V+ Sbjct: 421 NFVVAEVL 428 >UniRef50_Q0AWF7 Putative uncharacterized protein n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AWF7_SYNWW Length = 416 Score = 432 bits (1111), Expect = e-119, Method: Composition-based stats. Identities = 119/409 (29%), Positives = 187/409 (45%), Gaps = 21/409 (5%) Query: 27 TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHL 86 I GL R+ + +G + +AGTNGKG+T L ++L AGY+VG + SPH+ Sbjct: 5 GIKPGLSRIEALLREMGHPEKCLKTVHIAGTNGKGSTSFILSAVLSQAGYRVGRFISPHI 64 Query: 87 VRYTERVRVQGQELPESAHTASFAEIESARGDIS--LTYFEYGTLSALWLFKQAQLDVVI 144 Y ER + + E A+++ ++S T FE T AL F+ Q+D+ I Sbjct: 65 HSYRERFTINDTFIEEEEFLFYMAQVKKHIKNLSQRPTEFEILTAIALEYFRDKQVDLAI 124 Query: 145 LEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE-- 202 EVG+GG D+TN+++ V+V+T I DHT +LG E I R KAGI + + P ++G Sbjct: 125 FEVGMGGIYDSTNVIEPVVSVITGIDYDHTQYLGTSLEEIARNKAGIIKKKVPLVMGPVN 184 Query: 203 PEMPSTIADVAQEKGALLQ-----RRGVEWNYSVTDHDWAFSDAHGTLENLPLP---LVP 254 P IA A+E + L E S+ + ++ + LP Sbjct: 185 PPARQVIAARARELDSPLYPSSLAEVTREAQASLEGQLLKLVFSGQVVDKVFLPSPASYQ 244 Query: 255 QPNAA---TALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAE 311 N A TAL L+ +G +E ++ +A +PGR +IV +P I D AHNP AA Sbjct: 245 LENLAVAFTALQVLKMAGFLWTEGDMKAALAKLRIPGRMEIVRINPPFILDAAHNPQAAS 304 Query: 312 YLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEH 371 L + + + V+G+L DKD L L + EG R ++L E Sbjct: 305 VLASSLNDILPGKKKALVLGVLDDKDAQNILKPLGHNTRVLVLSRPEGSRSKNWKRLKED 364 Query: 372 L------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 + + + +A + K D +L+ GSF+ + + + Sbjct: 365 WLSLFPGADLYMEEDIIEAIKVGESLLKLGDYLLITGSFYLLDKARKYL 413 >UniRef50_D2R4J4 FolC bifunctional protein n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R4J4_9PLAN Length = 465 Score = 432 bits (1111), Expect = e-119, Method: Composition-based stats. Identities = 135/455 (29%), Positives = 192/455 (42%), Gaps = 52/455 (11%) Query: 14 ASWLSYLENL---------HSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 + L YL + L+R+ + A LG + GT GKG+T Sbjct: 11 QTALDYLLGRINYERTVTVPHQGKGFRLQRMQSLLALLGNPHYNWPAVHITGTKGKGSTS 70 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS---- 120 + SILMA+GYKVG+Y+SPHL ER V GQ++ EI SA + Sbjct: 71 LMMASILMASGYKVGLYTSPHLEHLEERFVVDGQQISSEVLVELVREIRSAVDQLDAEAE 130 Query: 121 --------LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALD 172 T+FE T A+ F + ++D+ +LEVGLGGRLD+TN+ +TSI+ D Sbjct: 131 ARGDLEGGPTFFEVTTAMAMLHFAREKVDIAVLEVGLGGRLDSTNVCHPIATAITSISFD 190 Query: 173 HTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY- 229 H LG ++I REKAGI + P I G E I +A E+ A L + G E+ Sbjct: 191 HMRQLGNTLDAIAREKAGIIKPGVPMICGVLANEPREAIEAIASEQRAPLVQLGKEFEAI 250 Query: 230 -----SVTDHDWAFSDAHGT-----LENLPL---PLVPQPNAATALAALRAS---GLEVS 273 + + G L ++ L N A A+A G +S Sbjct: 251 DLGASPSGGQLMHYREPSGREGAWELNDVELAMPGAHQVRNGAIAIAICHQLVQQGYRIS 310 Query: 274 ENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGML 333 IR G+ASA R + V+ P VI DVAHN + E L + + R + ++ Sbjct: 311 PATIRQGLASARAQARIERVNIRPAVILDVAHNVASIEALADVISQQFSSHRKILILASS 370 Query: 334 HDKDIAGTLAWLKSVVDDWYCAP-LEGPRGATAEQLLEHLGNG-----------KSFDSV 381 DK+ + L L + D L PR QLLE ++ DS Sbjct: 371 RDKETSAMLGALLPLFDHVILTCYLLNPRAVEPPQLLEMARRVLSESKLPEPMLETADSP 430 Query: 382 AQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 A A+ AM A ED V + GSF + ++ Sbjct: 431 ASAYARAMELAGGEDLVCITGSFFLAGEIRPLLKR 465 >UniRef50_Q12D50 FolC bifunctional protein n=4 Tax=Proteobacteria RepID=Q12D50_POLSJ Length = 501 Score = 431 bits (1109), Expect = e-119, Method: Composition-based stats. Identities = 192/479 (40%), Positives = 254/479 (53%), Gaps = 75/479 (15%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + L WL++ E LH K+ID+GLERV VA R+G+ A V TVAGTNGKG+TC L Sbjct: 11 EQLKTLQDWLAHCERLHPKSIDMGLERVQAVARRMGLA-FACPVITVAGTNGKGSTCAML 69 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR----GDISLTY 123 E+IL+ AGY+ GVY+SPHLV + ER RV+G + + A+FA +E+AR +ISLTY Sbjct: 70 EAILLEAGYRTGVYTSPHLVHFEERCRVRGDIVNATDLVANFARVEAARVQNGDEISLTY 129 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE+ TL+ L L A+LDVVILEVGLGGRLDA NI+D D AV+TSI LDH ++LG DRES Sbjct: 130 FEFTTLAILQLLADAKLDVVILEVGLGGRLDAVNILDTDCAVITSIDLDHMEFLGNDRES 189 Query: 184 IGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 IGREKAGI R+ KP +V +P P +I D A GA L R G ++N+S W++ Sbjct: 190 IGREKAGIMRAGKPVVVSDPVPPQSILDHAAALGADLWRFGQDFNFSGDKQQWSWVGRAD 249 Query: 244 TLE-------------------NLPLPLVPQPNAATA----------------------- 261 T + P A+TA Sbjct: 250 TGPPQGSTAPSGGSAVHEVTSVGAKVRRAGPPQASTAPSGGSAAHEVASVGAKTYRRYAG 309 Query: 262 ------------------LAALRAS--GLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 LAAL A L V+ A+R+G++ LPGRFQIV P ++ Sbjct: 310 LAYPALRGANQLVNASGVLAALTALRDRLPVTAQAVRNGLSMVELPGRFQIVPGQPTLVL 369 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 DVAHNPH+ L + A+ AV G + DKD+A LA + ++D WY L R Sbjct: 370 DVAHNPHSVAALAENLDAMGFYPCTHAVFGAMADKDLAPMLARVGPLIDKWYFTDLPTAR 429 Query: 362 GATAEQLLEHLGNGKSFDSVAQ--------AWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A+ E+L +S V A AA+ A D ++V GSF+TV V++ Sbjct: 430 AASGEELAAKWQAVESRPDVTATTHKDPELALQAAVRAAGPADRIVVFGSFYTVGGVLK 488 >UniRef50_B8CY17 Folylpolyglutamate synthase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CY17_HALOH Length = 457 Score = 431 bits (1109), Expect = e-119, Method: Composition-based stats. Identities = 130/440 (29%), Positives = 215/440 (48%), Gaps = 46/440 (10%) Query: 18 SYLENLHSKT----IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 Y+ +L GL+R++ + + V VAGTNGKG+T L+SI Sbjct: 5 KYINSLSRFGTDAGFKPGLDRINALLGSFNHPEDRLKVIHVAGTNGKGSTIAFLKSIYTE 64 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTYFEY 126 AGY+VGVY+SPHL+ + ER+ V + + + T +E+ D+ TYFE+ Sbjct: 65 AGYRVGVYTSPHLIHFNERIEVGNRAISTAELTDLVSELVPRVEDLKKDPEVGGPTYFEF 124 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIG 185 T AL F + +D+V+LEVGLGGRLDATN++ + V+V+TSI+LDHT LG D +SI Sbjct: 125 VTALALLYFARKDVDLVLLEVGLGGRLDATNVIKEPLVSVITSISLDHTSILGNDVKSIA 184 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-------- 235 REK+GI + + P + G E I + A+ K + L+ E++Y++ + Sbjct: 185 REKSGIIKRDCPVVTGVRNKEALRVIEETAKLKNSPLKIIDKEYSYNIIESSLEGQSFTV 244 Query: 236 WAFSDAHGTLEN--------------LPLPL-VPQPNAATALAALRAS--GLEVSENAIR 278 + ++ +LE + LP NA A+A + V+ I+ Sbjct: 245 FRLNNGDYSLEKEAESINGTEKIEYFIKLPGVYQVRNALLAMAVVDYLQEQYPVNLVQIK 304 Query: 279 DGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKAL-PKNGRVLAVIGMLHDKD 337 G+ASA +PGR ++++ SP +I D AHN + L + L ++ + ++G+L DKD Sbjct: 305 KGLASAFIPGRMEVLARSPLIIADGAHNVEGVKKLVNSLGPLINEDRQFYIIVGILGDKD 364 Query: 338 IAGTLAWL--KSVVDDWYCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMAD 391 + G + L + R + E + ++ + + + + + D Sbjct: 365 VEGMIEMLDFGKAKKELIITRNTNSRSCSPEVIGQYAQRRGIKYRVYPDLKTSLTGVLND 424 Query: 392 AKAEDTVLVCGSFHTVAHVM 411 A+ ED + V GS +TV+ Sbjct: 425 ARPEDVICVTGSLYTVSEAK 444 >UniRef50_D0MEF9 FolC bifunctional protein n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MEF9_RHOM4 Length = 442 Score = 430 bits (1106), Expect = e-119, Method: Composition-based stats. Identities = 139/424 (32%), Positives = 198/424 (46%), Gaps = 28/424 (6%) Query: 15 SWLSYLENLHSK------TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 L+YL +L GLER+ + A +G A +AGTNGKG+T L Sbjct: 2 DALNYLLSLPRFTDQGRAAYRPGLERMGALLAAMGAPHRAYPCVHIAGTNGKGSTASLLA 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 +I AAGY+VG+++SPHL ER+R+ G P + + A + ++FE Sbjct: 62 AIARAAGYRVGLHTSPHLWHVGERMRIDGIPAPTTWLEKAVARCRPLFEQVQPSFFEATV 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 + F + Q+D+ ++EVGLGGRLDATN+V +AV+TSI LDHTD LG E+I REK Sbjct: 122 ALSFLYFAEQQVDLAVVEVGLGGRLDATNVVQPRLAVITSIGLDHTDILGETIEAITREK 181 Query: 189 AGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH-----DWAFSDA 241 AGI + P + G +PE + I + A + A L E + Sbjct: 182 AGIIKPGVPVLTGVTQPEALAVIRETAARQQAPLHYLWEEVHLEQVAPETVFMRLTARTP 241 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSE-----NAIRDGIASAI----LPGRFQI 292 E+L + L + AA AL A+RA+ L + E IR G+ L GRF + Sbjct: 242 ARRYEDLEVGLPGRHQAANALLAIRAAELVLPEVLDDPRPIRQGLRDVRQLSGLRGRFDV 301 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKN--GRVLAVIGMLHDKDIAGTLAWLKSVVD 350 + P V+ DVAHNP + + AL GR A+ L DKD L Sbjct: 302 LQTRPLVVADVAHNPDGLAAVLTTIDALHPPGTGRRYAIWSALRDKDAPTMAGQLVQAGF 361 Query: 351 DWYCAPLEGPRGATAEQLLEHLGNGK----SFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 Y A LE PR +A +L+ + +VA W +A+D +L+ GS Sbjct: 362 SVYVAALESPRAWSAVELVAMVQQVGGQVPGVGTVASGWQLLQKRLQADDVLLITGSHQV 421 Query: 407 VAHV 410 VA + Sbjct: 422 VAAL 425 >UniRef50_UPI0000E88026 folylpolyglutamate synthetase n=1 Tax=Methylophilales bacterium HTCC2181 RepID=UPI0000E88026 Length = 423 Score = 430 bits (1106), Expect = e-119, Method: Composition-based stats. Identities = 145/411 (35%), Positives = 219/411 (53%), Gaps = 13/411 (3%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L +WL Y+E LH I+L LERV V L + P + V GTNGKG+ C +ESI Sbjct: 9 DSLEAWLDYIEKLHPSEIELTLERVREV-KDLANISPDFPIILVGGTNGKGSVCAFIESI 67 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L A+ K+G Y+SPHL+R+ ER+R+ E+ + A + IE +R DI LTYFE TL+ Sbjct: 68 LHASDLKIGCYTSPHLLRFNERIRINKHEVDDKAIVNALDHIERSRRDIPLTYFEITTLA 127 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A+ +D+ ILEVGLGGRLDA NI ++++T+++LDH +LG + IG EK+G Sbjct: 128 AVKCMNDEAVDIAILEVGLGGRLDAVNIFSPTISLITTVSLDHQAYLGDSVDKIGFEKSG 187 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 IFR PAI+ ++ A + A L G ++N + D +++ + +LPL Sbjct: 188 IFRRNIPAIINHKNPIPSMISAANKINANLSLLGNDYNLVIHDKSLSYTSNDLSYSDLPL 247 Query: 251 P----LVPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 P N A AL + + +S AI+ GI+ A + GRF+++ +P V+ DVA Sbjct: 248 PQIKGNHQIINLAGALRCIELLNSTIPISIKAIKKGISDASIRGRFEVLLNNPLVVVDVA 307 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNP +A L +G A+ + DKD+ + +V+D WY A L R + Sbjct: 308 HNPESANNLANNFMDAKLDGITTAIFSVFEDKDVLSIIQPFINVIDKWYIAELSSERALS 367 Query: 365 AEQLLEHLGNGKS------FDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 E + E L + F +V A+ A+ +A D +L+ GSF ++ Sbjct: 368 CEGIEEALKSVMPTVTVEKFPTVRHAYKEALKNAHDNDNILMFGSFLVISE 418 >UniRef50_Q28WD6 FolC bifunctional protein n=2 Tax=Rhodobacterales RepID=Q28WD6_JANSC Length = 421 Score = 429 bits (1105), Expect = e-119, Method: Composition-based stats. Identities = 141/419 (33%), Positives = 199/419 (47%), Gaps = 26/419 (6%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLESILM 72 L+ + LH K IDL L+R+ + LG + P V VAGTNGKG+T + + L Sbjct: 6 DQLLARMMALHPKIIDLTLDRMWRILYALGDPQTRIPPVIHVAGTNGKGSTQAMIRAGLE 65 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AG Y+SPHL R+ ER+R+ G+ + E + +A G +TYFE T +AL Sbjct: 66 GAGLTTHAYTSPHLARFHERIRLAGELIDEDHLSRILDTCLAANGPDPITYFEITTAAAL 125 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 F Q D +LEVGLGGRLDATN++D ++V+T I LDH +LG E+I EKAGI Sbjct: 126 HAFAQMPADYTLLEVGLGGRLDATNVIDAPALSVITPIDLDHQQFLGDTLEAIAGEKAGI 185 Query: 192 FRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 + P +VG E I A GA + G W+ + F D G L +LP Sbjct: 186 IKRGIPVVVGPQQDEALEVIEARAARLGAPVIAHGQHWHVTTERERLIFQDETGLL-DLP 244 Query: 250 LPL----VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR------- 298 LP NA TALAALR G+ + I P R Q + P Sbjct: 245 LPSLAGPHQIQNAGTALAALRTLGVG----DADAAMTDTIWPARMQKLRHGPLTEVAPSV 300 Query: 299 -VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 + D HNPHAA + ++ L + GML+ KD+ G +A L V+ + Sbjct: 301 ELWLDGGHNPHAARAIAATLETL-PKRPTYLICGMLNTKDVTGYMAPLVPWVESLTAVSI 359 Query: 358 EGPRG-ATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDT---VLVCGSFHTVAHVME 412 G +AE+ E + +A DAA+ + +D VL+CGS + +++ Sbjct: 360 PGQTATLSAEETAEAARSVGLTTRIAPGVDAALTEIAVDDPRARVLICGSLYLAGEILK 418 >UniRef50_B7RU63 FolC bifunctional protein n=1 Tax=marine gamma proteobacterium HTCC2148 RepID=B7RU63_9GAMM Length = 431 Score = 429 bits (1104), Expect = e-119, Method: Composition-based stats. Identities = 169/423 (39%), Positives = 237/423 (56%), Gaps = 13/423 (3%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 + LA WL +LE LH ++LGL+RVS VA LG+L + V TVAGTNGKG+T LE Sbjct: 2 TSKTLAQWLQHLETLHPNEMELGLDRVSQVADTLGLLPLSSPVVTVAGTNGKGSTVAVLE 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 S+L G++ G ++SPH +R+ ER+RV G E + A+F IE R ISLTYFE+ T Sbjct: 62 SLLRECGFRPGAFTSPHFLRFNERIRVGGNEAQDEQLIAAFEAIEGVRDGISLTYFEFST 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+AL +F++ ++D V+LEVGLGGRLD+ N+VDAD+AV+TSI LDH DWLG R I REK Sbjct: 122 LAALMVFEREEVDYVLLEVGLGGRLDSANMVDADIAVITSIDLDHQDWLGDTRGVIAREK 181 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGA-LLQRRGVEWNYSVTDHDW-----AFSDAH 242 AGI R KP ++ +PE P + +VA+++ A L R G E+++S W A Sbjct: 182 AGIMRVGKPVVIADPEPPGELLEVARDRAAGPLYRLGQEFDFSGPADRWQGRVQALKGDK 241 Query: 243 GTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP-RVIF 301 L++L + N A A G+E E+ ++ I +I PGR Q + + Sbjct: 242 KLLQHLSSVSLLPANVCAAAQAAVLLGVEFGEDQLQRAIDGSIRPGRLQRMELGGFHYLL 301 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP-LEGP 360 DVAHNP A + L + A P NG+V+A+ + DK I L D W+ + P Sbjct: 302 DVAHNPAAIDKLLENIAASPCNGKVIALFSAMKDKAIDEMLEACSGHFDAWFLGEQPDNP 361 Query: 361 RGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 R Q+ E L ++ QA+ A ED ++V GSF TVA V+ ++ Sbjct: 362 RAMPTAQIAELLREQGQEAISISKNLRQAFRRAQTVMNGEDLLVVFGSFFTVAAVLPQLE 421 Query: 416 ARR 418 R Sbjct: 422 KDR 424 >UniRef50_D2QCN6 FolC bifunctional protein n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QCN6_9SPHI Length = 428 Score = 429 bits (1104), Expect = e-118, Method: Composition-based stats. Identities = 128/425 (30%), Positives = 194/425 (45%), Gaps = 29/425 (6%) Query: 13 LASWLSYLENL-------HSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 + YL + K I GL L+ LG VAGTNGKG+T Sbjct: 3 YTEAIDYLYSRLPVFHRIGPKAIKPGLGNTLLLCEGLGNPHQQFTSIHVAGTNGKGSTSH 62 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 L +I +AGY+VG+Y+SPHL +TER+R+ G+ +PE + + + ++FE Sbjct: 63 MLAAIYQSAGYRVGLYTSPHLKSFTERIRLNGRPIPEEEVVRFVEQQQPLIESVEPSFFE 122 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 A + F + +D+ I+EVGLGGRLD+TN++ +V+T+I DHTD LG I Sbjct: 123 VTVAMAFYFFARHAVDIAIIEVGLGGRLDSTNVITPIASVITNIGYDHTDILGDTLPLIA 182 Query: 186 REKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYS-------VTDHDW 236 EKAGI + P I+GE PE V+ A + ++ + + Sbjct: 183 AEKAGIIKPGVPVIIGESHPETQEVFTSVSASLQAPITFADRQYLVNDLGLVDGIRQASI 242 Query: 237 AFSDAHGTLENL-PLPLVPQPNAATALAALRAS--GLEVSENAIRDGIASAI----LPGR 289 + D G L L L N A + V+ ++G+AS L GR Sbjct: 243 SRGDGSGWLAQLDLLGAYQLKNLPGVFATVEQLQQQFPVTAAQQQEGLASVSLLTGLKGR 302 Query: 290 FQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV 349 FQ + PRVI D AHN E L ++++ + +IG++ DKD + L+ L Sbjct: 303 FQTLGSHPRVIADTAHNQPGLEALFDTIRSI-PYKTLRIIIGLVADKDRSKVLSVL-PTN 360 Query: 350 DDWYCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFH 405 +Y PR +A+ L + G F V A AA+ A +D +L+ GS + Sbjct: 361 AVYYFCQANTPRSLSAQLLQQEARVLGRIGDVFTDVNTALAAALEQADPDDLLLITGSNY 420 Query: 406 TVAHV 410 T+A + Sbjct: 421 TIAEL 425 >UniRef50_D1PA28 Tetrahydrofolate synthase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PA28_9BACT Length = 412 Score = 429 bits (1103), Expect = e-118, Method: Composition-based stats. Identities = 118/423 (27%), Positives = 203/423 (47%), Gaps = 39/423 (9%) Query: 13 LASWLSYL-------ENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 + YL E + +K GL+ + + G +AGTNGKG++ Sbjct: 3 YQETVEYLFTSTPVFEKIGAKAYKPGLDTMYKMDEHFGHPHNQYKCIHIAGTNGKGSSSH 62 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 TL +IL + GYKVG+++SPHLV + ER+R+ G+ + E + ++FE Sbjct: 63 TLAAILQSQGYKVGLFTSPHLVDFRERIRINGEMVSEEYVIDFVENNRKFFEPLHPSFFE 122 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T+ A F + ++D ++EVGLGGRLD+TNI+ ++V+T+I+ DHT +LG I Sbjct: 123 LTTMMAFQYFAEQKVDFAVIEVGLGGRLDSTNIITPILSVITNISFDHTQFLGNTLGEIA 182 Query: 186 REKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 EKAGI + + P ++GE E A E+ + + TD D F Sbjct: 183 GEKAGIIKPKIPVVIGEWNEETQPVFIKKAHEQNSPIHFAHE------TDADMNFELK-- 234 Query: 244 TLENLPLPLVPQPN---AATALAALRASGLEVSENAIRDGIASAI----LPGRFQIVSES 296 + N + A+ L+ G+E+ + +I++G L GR++ ++E Sbjct: 235 -------GNYQKKNFCTISAAVECLKEEGIEIKDQSIKNGFEHVCELTGLRGRWEKLNEH 287 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD---WY 353 P I D HN EYL ++ ++ + + V GM+ DKD+ + L+ + + +Y Sbjct: 288 PLTICDTGHNLAGWEYLEPQIASVKADTK-HIVFGMVDDKDVEHVMELLEKLPKESTIFY 346 Query: 354 CAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 R ++L + NG + ++AQA++ A A+AK +D + + GS + VA Sbjct: 347 WTQPSTKRAIPVDKLFGYAQKHGLNGTCYQTIAQAFNTAKANAKKDDFIFIGGSSYVVAD 406 Query: 410 VME 412 ++ Sbjct: 407 LLS 409 >UniRef50_B3ELQ9 FolC bifunctional protein n=2 Tax=Chlorobiaceae RepID=B3ELQ9_CHLPB Length = 436 Score = 428 bits (1102), Expect = e-118, Method: Composition-based stats. Identities = 130/427 (30%), Positives = 192/427 (44%), Gaps = 17/427 (3%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNGKGTTCR 65 +++L LH + GLER+ + +G + V +AGTNGKGT Sbjct: 10 ESRNVTYQDAINFLFPLHRFGMKPGLERIRSLLNAVGNPQKRLGKVVHIAGTNGKGTVAY 69 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 + SI +AG+ G+Y+SPHLV +TER+ V G +PE A ++ D T+FE Sbjct: 70 AVASIFSSAGFTTGLYTSPHLVSFTERICVNGCRIPEPQVAAYCDVLKEEVADRKATFFE 129 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T A F + Q +V ++E G+GGRLDATN+VD D ++ SI DHT WLG E I Sbjct: 130 VTTAMACMYFAEMQAEVSVIETGMGGRLDATNVVDPDYVIIPSIGKDHTAWLGDTVEKIA 189 Query: 186 REKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRR-----GVEWNYSVTDHDWAF 238 EKA I + +P I A GA L V + +V + ++ Sbjct: 190 AEKAAIIKKGSRVYTAVKDPAALKPIIGRAAAVGATLHVLQDFPEPVVHSAAVGELVFSL 249 Query: 239 SDAHGTLENLPLPLVPQPNAATA-LAALRASGLEVSENAIRDGIASAILPG---RFQIVS 294 L + +A+ LA L A + E +IR G+ S G R + +S Sbjct: 250 KARGADFRKLKSGVTGDFHASNLELAVLAAHDAGIEERSIRKGLLSMRDFGYRARLERLS 309 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKAL-PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 P ++ DVAHNP E + VL V+G++ DKD+A + LK + Sbjct: 310 GKPDLLLDVAHNPDGMEKSVNTLLRFSHAYRNVLVVLGLVRDKDVAEVVRCLKKLTKTVI 369 Query: 354 CAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 L RG A +L N ++ A+A D A +D VLV GSF+ Sbjct: 370 TVNLLSERGLPASELGGMCRNEGFHAIVAETAAEALDIVKRTADKDDLVLVTGSFYLAGE 429 Query: 410 VMEVIDA 416 V++++ Sbjct: 430 VLKLMKR 436 >UniRef50_A8F8Q4 FolC bifunctional protein n=1 Tax=Thermotoga lettingae TMO RepID=A8F8Q4_THELT Length = 441 Score = 428 bits (1101), Expect = e-118, Method: Composition-based stats. Identities = 115/430 (26%), Positives = 196/430 (45%), Gaps = 28/430 (6%) Query: 11 SPLASWLSYLENLHSKT-IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 L YL I LGL+R+ + RLG + +AGTNGKG+ R L Sbjct: 1 MTYLKMLEYLYKERPSGKITLGLDRIQKLCERLGNPQNVFKSAHIAGTNGKGSVTRFLSW 60 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR-------GDISLT 122 + + G K Y SPHL + ER+ V + + + +F E++ A + Sbjct: 61 LFIEHGLKTAAYYSPHLTSFKERILVDEKFITDETMLNAFHEVQQAAIELDKEGEQSKPS 120 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 +FE+ T A +++ + +EVGLGGR DATN++ +V+V+ ++ DH LG E Sbjct: 121 FFEFTTAMAFCVYRDMKTQAASIEVGLGGRFDATNVLTPEVSVIVTVGFDHMHILGNTLE 180 Query: 183 SIGREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYS-----VTDHD 235 I EKAGI + P + GE + I VA K + + G ++ Y ++++ Sbjct: 181 KIAFEKAGIIKENIPVVCGETNEIPLNVINQVAHLKNSSVYLLGKDFYYDNEKLFLSNNT 240 Query: 236 WAFSDAHGTLENLPLPLVPQPNAATALAALRAS-------GLEVSENAIRDGIASAILPG 288 + F L++L + L A AL+A +++ + IR ++ +PG Sbjct: 241 FDFHSDIIELKDLKISLNGAHQFLNASVALQAFLIFAQRNNIKIDKLRIRSALSKTTMPG 300 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 RF++V E P+VIFD AHN AA L +K ++ ++ AVIG++ DKD L + + Sbjct: 301 RFEVVGEKPKVIFDGAHNLSAALVLRKSIKDYLEDEKIAAVIGIVDDKDKRSILTQIAPM 360 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLGNGKS----FDSVAQAWDAAMADAKAEDTVLVCGSF 404 D R ++ + + +A++ + +T++V GS Sbjct: 361 FDRIVVTRPFSHRAQNTQETFQITREINANTILEPDPIKAYEILK--SDGYETIIVTGSL 418 Query: 405 HTVAHVMEVI 414 + V ++ + I Sbjct: 419 YLVGYLRDYI 428 >UniRef50_C0EHC4 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EHC4_9CLOT Length = 439 Score = 428 bits (1101), Expect = e-118, Method: Composition-based stats. Identities = 116/434 (26%), Positives = 190/434 (43%), Gaps = 19/434 (4%) Query: 4 KRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTT 63 K L ++ L + GLERV + LG + VAGTNGKG+ Sbjct: 7 KGRSNDMKDYQQALDWVHGLPPFSKRPGLERVRRLLDLLGNPQERLRFIHVAGTNGKGSV 66 Query: 64 CRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-----ARGD 118 SIL AGY+ G+Y SP ++ + ER ++ G+ + ++ T E+ Sbjct: 67 TTMCSSILREAGYRTGLYISPFVIDFRERFQIDGEMISKAEFTRLCQEVREGYETLRAQG 126 Query: 119 ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDAD-VAVVTSIALDHTDWL 177 I + ++ T +L F + D+V EVGLGG DATNI+ AV+ I+ DHT L Sbjct: 127 ILMNEYDVITALSLLYFHNHRCDIVCFEVGLGGLYDATNIIPPPEAAVIMKISYDHTAVL 186 Query: 178 GPDRESIGREKAGIFRSEKPAIV---GEPEMPSTIADVAQEKGALLQ---RRGVEWNYSV 231 G +I EKAGI + + E E + I + ++G L + G+E Sbjct: 187 GDTLTAIAGEKAGIIKRGSVCVCYPDQEEEALAVIMEQCAQQGVPLILPNQSGIELKQEG 246 Query: 232 TDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS-GLEVSENAIRDGIASAILPGRF 290 + +F E NA TA+ +R +VS +R G+A P R Sbjct: 247 LEGS-SFCYDGQEYELALPGHHQVLNAVTAIETIRQLRDFQVSGEQLRRGLAKTTFPARM 305 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 +++S+ P ++ D AHN + + L +K + + + +AV GML DKD LA L VD Sbjct: 306 ELLSQHPLLLLDGAHNANGVQALMQAVKKIEASPK-IAVAGMLADKDYGAELALLSGAVD 364 Query: 351 DWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHT 406 ++ R + +L + + + +A++ A+ A A+ V++ GS Sbjct: 365 QLILTQVQSARAESLSRLQDAAQGHGYPVSVCEDLREAYELALKMAGADGLVVIFGSLFL 424 Query: 407 VAHVMEVIDARRSG 420 + + +I + Sbjct: 425 ASDLRRIILGKGKD 438 >UniRef50_A8RF48 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM 3991 RepID=A8RF48_9FIRM Length = 405 Score = 427 bits (1099), Expect = e-118, Method: Composition-based stats. Identities = 116/409 (28%), Positives = 189/409 (46%), Gaps = 14/409 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + ++ +E ++ GL +G V GTNGKG+T + +IL Sbjct: 5 VDELIAEIEGRKNRG--YGLSHFQAYMESIGNPHLDLCAIHVGGTNGKGSTTNYVRAILQ 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AAGY+VG ++SP+L+ + +R+R+ E+ E+ + ++ + L+ FE A Sbjct: 63 AAGYRVGSFTSPYLITHRDRIRINDIEISEADFLKIANDYYASWIEWDLSMFEIDMCIAS 122 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 FKQ ++D + EVGLGGRLDATN++ ++V+T+I +DH++ LG +I +EKAGI Sbjct: 123 VYFKQQKVDYCVFEVGLGGRLDATNVLQPLLSVITNIGMDHSELLGDSYTAIAKEKAGII 182 Query: 193 RSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS-DAHGTLENLP 249 + P + E E S A++A+EK + + N + F H ++ Sbjct: 183 KEGIPLVTAEKKAECCSVFAEIAKEKHSEVHVLKPIENRRCENLHILFDYGDHKQIKLAT 242 Query: 250 LPLVPQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNP 307 NAA A+ A+ L +SE +R +A+ GRF+IV + P VI D AHN Sbjct: 243 AADYQCENAALAIEAVSLLHGRLHISEEILRQALAATQWKGRFEIVQKEPLVILDGAHNV 302 Query: 308 HAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQ 367 E L + + + V +L DK+ L L + D L R ++ Sbjct: 303 EGIEALCDSLDNIHN---PVIVFSVLKDKNFTVMLEKLMGITDTMIVTKLHHERAYDMDR 359 Query: 368 LLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 L + DS A A A +A V++ GS + ++ V A Sbjct: 360 LAQQYDVCYIEDS-KTAIQQACAMKRA---VVITGSLYFISEVRAYFKA 404 >UniRef50_C6LLF0 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Clostridiales RepID=C6LLF0_9FIRM Length = 463 Score = 426 bits (1096), Expect = e-118, Method: Composition-based stats. Identities = 114/440 (25%), Positives = 189/440 (42%), Gaps = 29/440 (6%) Query: 4 KRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTT 63 K+ +SY+E++ T E + RLG + V VAGTNGKG+ Sbjct: 25 KKEVTFVMTYEEAVSYIESVPKFTTKNKPENTIEMIERLGRPERKMKVIHVAGTNGKGSV 84 Query: 64 CRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI---- 119 C L S+L A G K G++ SPHLV+ ER ++ + + ++ ++ ++ Sbjct: 85 CAFLSSMLTAGGKKTGLFISPHLVKINERFQINNVPVTDGEFLEAYEKVFKVIREMLADG 144 Query: 120 --SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDW 176 YFE L LF++ +++ +LE GLGGRLDATNIV+ V+TSI+LDHT+ Sbjct: 145 FAHPAYFEILFAVCLVLFERHEVEYAVLETGLGGRLDATNIVEHPLACVITSISLDHTEI 204 Query: 177 LGPDRESIGREKAGIFRSEKPAI---VGEPEMPSTIADVAQEKGALLQRRGVE----WNY 229 LG I EKAGI + P I PE I AQE+ A + + Sbjct: 205 LGDTIGQIAWEKAGIIKEGVPVIYDGCRSPEAEEVIRKRAQEQHAPAIGLHADMYEILDK 264 Query: 230 SVTDHDWAFSDAHGTLENLPLPL---VPQPNAATALAALRASGL--EVSENAIRDGIASA 284 + D+ + + + +P NA+ AL A+ E+S + +A Sbjct: 265 TDKSIDFKLNALYYEKRKITVPYPAPYQAENASLALLAMEKIDPSHEISCDVRLQAMADT 324 Query: 285 ILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAW 344 GR + V P VI D AHN + + + R++ + + +K+ + Sbjct: 325 HWQGRMETVL--PGVIVDGAHNEDGVRQFVRTLVGVQEGRRIVLLFSAVVEKNYEQMIKT 382 Query: 345 LKSV--VDDWYCAPLEGPRGATAEQLLEHLG-----NGKSFDSVAQAWDAAMADAKAEDT 397 + + + +EG R AE+L + + +A++ A+A + Sbjct: 383 ICDTGRLSEVIATQIEGKRIVPAEELAGIFRKYTDAEVTAVPDIGKAFETALAKRG-DGL 441 Query: 398 VLVCGSFHTVAHVMEVIDAR 417 + GS + V + +I+ R Sbjct: 442 LFCVGSLYLVGEIKALIEER 461 >UniRef50_A6LA17 Folylpolyglutamate synthase n=8 Tax=Bacteroidales RepID=A6LA17_PARD8 Length = 439 Score = 425 bits (1095), Expect = e-117, Method: Composition-based stats. Identities = 125/435 (28%), Positives = 202/435 (46%), Gaps = 23/435 (5%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 + L + + ++ + GL + LG A VAGTNGKG+ Sbjct: 2 TYEETLHYLYTSIPVFQHSGASAYKPGLGTSIALDDYLGNPHKAYKTIHVAGTNGKGSVS 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L +IL +G+KVG+Y+SPHLV + ER+RV G+++ + S + ++F Sbjct: 62 HLLAAILRQSGFKVGLYTSPHLVDFRERIRVNGKKISQDYVVDFVERHRSFFEPLHPSFF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E + A F+ Q++ ++EVGLGGRLD+TNI+ ++++T+I+LDHT +LG E I Sbjct: 122 ELTSSMAFEYFRDQQVNYAVIEVGLGGRLDSTNIITPILSIITNISLDHTQFLGDTEEKI 181 Query: 185 GREKAGIFRSEKPAIVGEPE---MPSTIADVAQEKGALLQRRGV------EWNYSVTDHD 235 EKAGI + PA++GE E + + A+E GA E +V Sbjct: 182 AAEKAGIIKKGVPALLGEAEKQSVYDVFKNKAEEVGAPFYYAQRMDMVKDECRLTVGGKW 241 Query: 236 WAFSDAHGTLENLPLPLVPQPNAATALAALR----ASGLEVSENAIRDGIASAI----LP 287 + S +G ++ V NA T L+A+ G+++ A+ +G A L Sbjct: 242 FFPSVEYGEIQGELGGEVQVRNAVTVLSAIHILRTELGVDIIPEAVHEGFAHVTKLTGLM 301 Query: 288 GRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKN-GRVLAVIGMLHDKDIAGTLAWLK 346 GR+Q + P VI D HN E+L +K L + G++ ++GM++DKDI G L+ L Sbjct: 302 GRWQTLRSKPTVICDTGHNVGGWEHLAEHLKVLRQYCGQIYMIVGMVNDKDIDGVLS-LM 360 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCG 402 ++ R E G D+V A + A+ A+ D + + G Sbjct: 361 PQDAFYFFTQASVERAMPVEDFAVKAMRHGLSGTLCDTVQDAVEKALRRARENDLIFIGG 420 Query: 403 SFHTVAHVMEVIDAR 417 S VA + + Sbjct: 421 STFIVADALPLFMKE 435 >UniRef50_D1CGA1 FolC bifunctional protein n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CGA1_THET1 Length = 451 Score = 425 bits (1095), Expect = e-117, Method: Composition-based stats. Identities = 124/444 (27%), Positives = 196/444 (44%), Gaps = 34/444 (7%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M I A + S+ Y N + LE V L+ +G + +AGT GK Sbjct: 1 MTINSYADALRYIYSFADYERNKPRSPEGMHLENVRLLLESVGNPHEKLKLVHIAGTKGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI- 119 G+T + S+L+++GYKVG Y+SPHL + ER ++ Q + E EI+ A ++ Sbjct: 61 GSTSAMISSVLISSGYKVGTYTSPHLHTHRERYQINAQPVNEDTFVNVLNEIKPAADELA 120 Query: 120 ---SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDW 176 +T +E T A LF++ +D ++EVGLGGRLD+TN++ V+V+T+I+LDHT+ Sbjct: 121 KDRKVTTYEITTALAFKLFEEEDIDWGVIEVGLGGRLDSTNVIIPKVSVITAISLDHTEV 180 Query: 177 LGPDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDH 234 LG I EKAGI + + P ++ E + A + + E + Sbjct: 181 LGDTLAKIAAEKAGIIKPQVPVVIAPQYQEAMEVLKQRALDNHSQALIVD-ELMEARNTQ 239 Query: 235 DWAFSDAHGTLEN-------------LPLPLVPQPNAATALAALRASGL-------EVSE 274 S TL +PL+ + AL A+ + L ++ Sbjct: 240 TEDLSSQSFTLHTKLCLHNQPLDSQSFTIPLIGRYQTDNALTAITTAWLLSQDAAPAINL 299 Query: 275 NAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLH 334 + +G+ + PGRF++V +P +I D AHNP + L +K L N R + V G Sbjct: 300 TTLMEGLRNVKWPGRFEVVPGTPLIILDGAHNPESVGKLKNTVKELLSNKRRIYVFGAGF 359 Query: 335 DKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMA 390 D G L L+ ++ PR E L + N + +V +A D A + Sbjct: 360 GHDFHGMLEQLRE--EELIICKSIHPRAVPPETLSQIASNLGIKHQVRPTVEEALDLAKS 417 Query: 391 DAKAEDTVLVCGSFHTVAHVMEVI 414 D V+V GS VA + Sbjct: 418 L-DDVDAVIVGGSLFVVADARLAL 440 >UniRef50_C0EVS7 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM 3353 RepID=C0EVS7_9FIRM Length = 435 Score = 425 bits (1094), Expect = e-117, Method: Composition-based stats. Identities = 118/430 (27%), Positives = 187/430 (43%), Gaps = 34/430 (7%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 +++S +E L + GL+ + + LG + + +AGTNGKG+ L SILMAA Sbjct: 2 NYISLIEELKKRGSIPGLDAIQGLLEELGHPEDDLKIVHIAGTNGKGSVFAYLSSILMAA 61 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG------DISLTYFEYGT 128 G+KVG Y SP + Y ER ++ G + + + +E A + T FE T Sbjct: 62 GFKVGRYISPTISCYEERFQINGTYIAKDKLERLYGVVEEAMRKEEAKIGLRPTLFEVET 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGRE 187 + FK+ ++D ++EVG+GGRLDATN++ ++ V++SI+ DH LG E I + Sbjct: 122 ALSFLYFKEEKVDYALVEVGMGGRLDATNVIKHPELTVISSISYDHKAILGDTLEEIACQ 181 Query: 188 KAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRR-GVEWNY-SVTDHDWAFSDAHG 243 KAGI + P ++ E+ + A EK ++ + T + F Sbjct: 182 KAGIIKESAPVVLSENPEEVCKVVKHEAAEKKVHCIEVKPQDYEILAETPYGSTFLWKEQ 241 Query: 244 TLENLPLPLVPQPNAATALAALRAS--------------GLEVSENAIRD----GIASAI 285 E NA TAL A E+ I+ GI I Sbjct: 242 RYETKLPGNHQISNAVTALTASEYLFEKDYEKNEARKKIPKELDTMNIKAAQQGGIIRTI 301 Query: 286 LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 PGR +++ + P D AHNP A L ++ N R++ ++G+L DK+ L +L Sbjct: 302 WPGRLEVLKKEPLFYRDGAHNPDGARKLASFLQKHFTNKRIIYIMGVLKDKEYTKILQYL 361 Query: 346 KSVVDDWYCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADAKAEDTVLV 400 + Y RG +AE L + V A A+ A+ ED ++ Sbjct: 362 MPMAKKVYVFRPNNERGLSAEILANTIKEKADVPVMIEPDVNTAVSKALEAAQPEDILVA 421 Query: 401 CGSFHTVAHV 410 CGS + + Sbjct: 422 CGSLSFMEEM 431 >UniRef50_B1CAR2 Putative uncharacterized protein n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1CAR2_9FIRM Length = 433 Score = 424 bits (1092), Expect = e-117, Method: Composition-based stats. Identities = 114/428 (26%), Positives = 190/428 (44%), Gaps = 24/428 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + Y+ + LGL+ + + RLG + V +AGTNGKG+ L +L Sbjct: 3 YKEAIEYIHMTNKFGSVLGLDNILNLLDRLGNPQKDLKVIHIAGTNGKGSISTMLNGVLT 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEY 126 AGY VG+Y+SP L ++ ER++ ++P+ E++ ++ T FE Sbjct: 63 QAGYNVGLYTSPFLEKFNERIKTNNMDIPDEDIAYYLTEVKEKINEMISEGLNHPTEFEI 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIG 185 T AL+ FK+ +D+VILEVGLGGRLDATN++ D + ++ SI+ DHT++LG + I Sbjct: 123 ITAMALYYFKEKNVDIVILEVGLGGRLDATNVIDDPILEIIASISFDHTEYLGNTLKQIA 182 Query: 186 REKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQR---RGVEWNYSVTDHDWAF-- 238 EK GI + I+ E + +++EK R +E + D + Sbjct: 183 YEKGGIIKENSKVILYPSHKEALDELIRISKEKNTSYIIGNKRDIELIKTDIDGSELYYK 242 Query: 239 SDAHGTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQI 292 + LE L L+ + AL L+ G ++++ I + + GRF+I Sbjct: 243 KENEFGLEKFRLSLLGENQIYNVLTVIKALETLKKDGYKINKCNIEKALTNIHFNGRFEI 302 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 ++ P +I D HN E +K K+ ++ GML DKDI L L + Sbjct: 303 FNKKPYIILDGGHNKEGIESFVKNIKLYFKDKKITLFFGMLADKDIDSALKKLIPLSKKI 362 Query: 353 YCAPLEGPRGATAEQLLEHLGNG---KSFDSVAQAWDAAMADAKAEDTVLVC-GSFHTVA 408 Y R T++ + E + + ++ + A K D + GS + + Sbjct: 363 YTLTPNNNRAYTSKDMYEKIKKVDNHIEATYLDESDEIAGIIDKNSDEIYAFVGSLYLIG 422 Query: 409 HVMEVIDA 416 V + Sbjct: 423 EVRTKLKN 430 >UniRef50_C6W460 FolC bifunctional protein n=7 Tax=Bacteroidetes RepID=C6W460_DYAFD Length = 433 Score = 424 bits (1092), Expect = e-117, Method: Composition-based stats. Identities = 119/431 (27%), Positives = 194/431 (45%), Gaps = 27/431 (6%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 + L L +N+ ++ GL + LG + +AGTNGKG+T Sbjct: 2 TYQETIEYLYDRLPVFQNIGARAFKPGLHTTRELCKLLGDPQDQFPTIHIAGTNGKGSTS 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L +IL AGY+VG+Y+SPHL + ER+RV G + E + +S +S ++F Sbjct: 62 HMLAAILQEAGYRVGLYTSPHLKDFRERIRVNGVPVSEDFIVDFIDDQKSNIERLSPSFF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E A F ++++DV ++EVG+GGRLD+TN++ +++V+T+I+ DH +LG I Sbjct: 122 EVTVAMAFSYFGRSKVDVAVIEVGMGGRLDSTNVITPELSVITNISFDHMQFLGDTLGKI 181 Query: 185 GREKAGIFRSEKPAIVGEP---EMPSTIADVAQEKGALLQRRGVEWNYSVTD--HDWAFS 239 EKAGI ++ P +V E E+ I A+ A L ++ + Sbjct: 182 AAEKAGIIKNAVPVVVSEDQNAEISDVITAAAENAQAPLTFAARAYDVTYVGMRDGLMLV 241 Query: 240 DAHGT------LENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASA--- 284 + ENL L L A AL + G + + A+ + + Sbjct: 242 NIQNRGSGDLEAENLALDLTGSYQLKNVAGVWAARKALLSKGWNICDEAVIRALRAVGSI 301 Query: 285 -ILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA 343 L GR+Q + ++P V D AHN + +++ K + VIG + DKDI+ L+ Sbjct: 302 TGLKGRWQQLGQAPNVYCDTAHNTAGLTATLAQFESVCKGKK-RFVIGFVGDKDISTMLS 360 Query: 344 WLKSVVDDWYCAPLEGPRGATAEQLLEHLGNG----KSFDSVAQAWDAAMADAKAEDTVL 399 L +Y R A +L ++F +V +A AA+ D+ D + Sbjct: 361 -LFPRDAQYYFCEPSNMRALKAPELQARALECGLAGETFGNVKEALAAALRDSAPTDAIY 419 Query: 400 VCGSFHTVAHV 410 V GS VA + Sbjct: 420 VGGSTFVVADI 430 >UniRef50_C6WVE3 FolC bifunctional protein n=1 Tax=Methylotenera mobilis JLW8 RepID=C6WVE3_METML Length = 458 Score = 424 bits (1092), Expect = e-117, Method: Composition-based stats. Identities = 181/447 (40%), Positives = 253/447 (56%), Gaps = 34/447 (7%) Query: 4 KRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTT 63 L++WL+Y+E LH I++GL R+ VA RL + KP + TVAGTNGKG+T Sbjct: 5 FSLEAPPKDLSAWLTYIEQLHPSAIEMGLGRIKTVADRLAL-KPTFKIITVAGTNGKGST 63 Query: 64 CRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD----- 118 C L I AGY+VG Y+SPH++RY ERV+V GQE +++ A+FA +E+AR Sbjct: 64 CTMLSQIYQHAGYRVGCYTSPHILRYNERVQVNGQEASDASLCAAFAAVEAARLGTANQS 123 Query: 119 --ISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDW 176 ISLTYFE GTL+A+W F Q +DV +LE+GLGGRLDA N + D +VT++ LDH D Sbjct: 124 FAISLTYFEIGTLAAVWHFVQTGVDVAVLEIGLGGRLDAVNAFEPDCTIVTNVDLDHQDL 183 Query: 177 LGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDW 236 LG RE IG EKAG++R+ PAI G+ PST+ A+E A L+ E+ Y + D W Sbjct: 184 LGDTRELIGYEKAGVYRASIPAICGDINPPSTLIAYAKEVKADLKCVQHEFGYELADAGW 243 Query: 237 AFSDAHGTLENLPLPL----VPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRF 290 + + + +LP+P NAA A+ A+ A L V+ +I + L GRF Sbjct: 244 YYLNNQQRVYHLPIPALKGQYQLTNAACAITAVTALQSVLPVALESIVKAMQEIKLMGRF 303 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALP--------KNGRVLAVIGMLHDKDIAGTL 342 P +IFDVAHNPHAA L +K+L + R+L+V ML DKDI G + Sbjct: 304 YTDERFPWLIFDVAHNPHAAVALAENLKSLKSLTSNKSGEPVRILSVFSMLADKDIKGVV 363 Query: 343 AWLKSVVDDWYCAPLEGPRGATAEQLLEHL------GNGKSFDSVAQAWDAA------MA 390 LK VD WY AP+E RG + + L+ + + K+F S+A A+ A Sbjct: 364 EILKGEVDTWYVAPIEHARGTSVKALVTAIHEVIPDASVKTFASLADAYTQAYLDRESCI 423 Query: 391 DAKAEDTVLVCGSFHTVAHVMEVIDAR 417 + D ++ GSF TV+ VM+ ++ Sbjct: 424 EQHENDKIVAFGSFFTVSSVMQYLNEH 450 >UniRef50_Q1N6P7 Folylpolyglutamate synthetase n=1 Tax=Bermanella marisrubri RepID=Q1N6P7_9GAMM Length = 422 Score = 424 bits (1091), Expect = e-117, Method: Composition-based stats. Identities = 178/420 (42%), Positives = 248/420 (59%), Gaps = 18/420 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L WL YLE+ H K IDLGL+RV VA RL ++KPA +V VAGTNGKGTT T + Sbjct: 5 LDQWLQYLESAHPKDIDLGLDRVRAVAERLDLIKPAKYVVLVAGTNGKGTTVATCGELFR 64 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 +G+ VGV++SPH+ +Y ERV + G+++ ++ SF IES RGDISLTYFE LSAL Sbjct: 65 QSGFSVGVFTSPHITKYNERVSINGKQVSDAQLIDSFEAIESKRGDISLTYFEVSALSAL 124 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +LFKQA ++ +LE+GLGGRLDA N+VD DV++VTSI LDH DWLG + IG EKAG++ Sbjct: 125 YLFKQANVEAAVLEIGLGGRLDAVNLVDPDVSIVTSIGLDHQDWLGDTLDKIGYEKAGVY 184 Query: 193 RSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH-DWAF-----SDAHGTLE 246 R KPAI G+ PS + A E A L + ++++ + + + + S Sbjct: 185 RQSKPAICGQVNPPSGLLAHANEIDAKLLIKHQDFHHQLNEQGGFDWFGVNASGERIVFN 244 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIV------SESPRVI 300 +LPLP VP NA TAL A+ +E + +R + + + GR Q +S + Sbjct: 245 DLPLPKVPIENACTALQAMMMLPIEWAIEDVRLALQNVFVEGRLQAFCYQGSSGQSVSGM 304 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 DV HNP AAE+L + GRV AV+ ML DK+ + LK VD W A L+G Sbjct: 305 LDVGHNPQAAEFLLQYIPE--TKGRVFAVLAMLQDKNPNDVVTALKDRVDQWCFAGLQGY 362 Query: 361 RGATAEQLLEHLGNG----KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 RG TA++L+ + + + F SV+QA + M + +D V+V GSF TV+ ++ Sbjct: 363 RGQTAQELMSRIDHLPHGSRDFHSVSQAMECVMEEVTCDDYVVVLGSFLTVSAAKSWLEQ 422 >UniRef50_UPI0000E0E8A2 FolC bifunctional protein n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=UPI0000E0E8A2 Length = 425 Score = 424 bits (1090), Expect = e-117, Method: Composition-based stats. Identities = 179/423 (42%), Positives = 243/423 (57%), Gaps = 16/423 (3%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 T A + L WL++LE++H ID+GL+RV V RL + V TVAGTNGKGTTC Sbjct: 2 TLTADASLMEWLTHLESIHPVGIDMGLDRVQAVYQRLNLDWSGVTVITVAGTNGKGTTCA 61 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 +E+ + GY+VGVYSSPH+ Y ERVR+ Q L ++AHT +FA IE+ARG+ISLTYFE Sbjct: 62 FIEAAAIQCGYEVGVYSSPHINTYNERVRINQQLLDDTAHTQAFAAIEAARGNISLTYFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 +GTL+ LWL Q LDV +LEVGLGGRLDA N+VD D+AV+TSI LDH +LG R I Sbjct: 122 FGTLAGLWLLHQQALDVAVLEVGLGGRLDAINVVDPDIAVITSIGLDHQAFLGDTRALIA 181 Query: 186 REKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 +EKAGI R+ KP I+GEPE P T+ + A Q ++ Y + + + F L Sbjct: 182 QEKAGIMRAGKPVIIGEPEPPHTLREAVVSYAADAQWVSQDFAYHIEHNLFHFKMGSTQL 241 Query: 246 ENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIV------SESPRV 299 +LPLP +P PNAATA+A + VS + A L GR ++ SE+P + Sbjct: 242 -SLPLPHIPFPNAATAMAVVHQLAWPVSASQWAYCAAHTRLNGRLTVLTEHAFGSEAPVI 300 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 + D AHN A+EYL + L RV AV G++ DKD AG A L +V WY ++ Sbjct: 301 MLDAAHNIQASEYLATHIAHLAP-RRVFAVCGIMQDKDWAGVCAPLVPLVSHWYPCDVQI 359 Query: 360 PRGATAEQLLEHL--------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 R A + L + ++ + A+ A +D VL+ GSF T++ Sbjct: 360 ERAAKGSDIAACLVNSLAINKTQVTAVNTPYEGVVNAIKTATNQDLVLIFGSFFTLSDFY 419 Query: 412 EVI 414 + Sbjct: 420 AQL 422 >UniRef50_B8KYD9 Folylpolyglutamate synthase n=1 Tax=gamma proteobacterium NOR51-B RepID=B8KYD9_9GAMM Length = 409 Score = 423 bits (1089), Expect = e-117, Method: Composition-based stats. Identities = 168/409 (41%), Positives = 230/409 (56%), Gaps = 8/409 (1%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + LA WL YLE LH + IDLGLERV VA L + P TVAGTNGKG+ + Sbjct: 5 ADLADWLRYLEGLHPRAIDLGLERVGAVADALELRPPRCSTLTVAGTNGKGSVVAVTAAG 64 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L AAG+ VGVY+SPHL+ + ER+ + + +P+ A A+F EIE +RGDISL+YFE+ TL+ Sbjct: 65 LRAAGHSVGVYTSPHLIDFNERIVIDDKPVPDEALLAAFEEIERSRGDISLSYFEFATLA 124 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 ALWLF++A +D +LEVGLGGRLDA NI+D D+AV+TSI LDHT+WLGP RE+I EKAG Sbjct: 125 ALWLFRRASVDWQVLEVGLGGRLDAVNILDPDIAVITSIGLDHTEWLGPTREAIAPEKAG 184 Query: 191 IFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 I R KP +V E + P ++A+ + GA ++ RG +W S G + + Sbjct: 185 IARRGKPVVVLETDPPDSLAESLESMGADIKWRGRDWTMSAEQVHL---CDGGQVALPDI 241 Query: 251 PLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQ-IVSESPRVIFDVAHNPHA 309 + N AL AL +G+ + + D +AS +PGR Q + V+ DVAHN + Sbjct: 242 DGLLSDNIGGALQALSLAGVVID-APMLDELASVRVPGRRQRRHWKGHEVLLDVAHNLES 300 Query: 310 AEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGATAEQL 368 E + +++LP R LA+ + DK I L D W+ L E PR + Sbjct: 301 VEAMVASLESLPGGERTLALFAAMADKPIHAMLNACAGCFDRWFLPDLAEQPRAMKPADI 360 Query: 369 LEHLGNG--KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + FD AW A A D ++V GSF TV + +D Sbjct: 361 AALMPEVISTCFDDFDDAWSAVTAALVPGDRLIVFGSFITVGAALARLD 409 >UniRef50_B0MYL2 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MYL2_9BACT Length = 430 Score = 423 bits (1089), Expect = e-117, Method: Composition-based stats. Identities = 122/430 (28%), Positives = 190/430 (44%), Gaps = 32/430 (7%) Query: 13 LASWLSYLEN-------LHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 L +L + + GLER++ LG + F VAGTNGKG+ Sbjct: 3 YNQTLEFLFSSLVSYQEKGPEAYKPGLERITAFCKHLGNPQRNYFTIHVAGTNGKGSVSH 62 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 L S+L AGY+ G+Y+SPHL + ER+ V G+ +P+ + ++ L++FE Sbjct: 63 MLASVLQQAGYRTGLYTSPHLRDFRERILVDGEMIPKQKVVNFVDKHYDCMKELGLSFFE 122 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T A F Q+ ++V ++E GLGGRLDATN++ V+V+T+I LDH LG I Sbjct: 123 MSTALAFDYFDQSDVEVAVIETGLGGRLDATNLIIPIVSVITNIGLDHMALLGDTLPKIA 182 Query: 186 REKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS---- 239 EKAGI + P ++GE E A + + ++ + F Sbjct: 183 AEKAGIIKKSIPVVIGEKSDEYNHVFDQAATAMMSKIVYAENDFACINHSTEGDFQKFSI 242 Query: 240 --DAHGTLENLPL---PLVPQPNAATALAALRAS----GLEVSENAIRDGIASA----IL 286 + NL L N TA+A + L +S A+ +G+ + L Sbjct: 243 QRHRDNKVFNLELDLTGNYQVHNILTAIAVIDLLHQETPLTISLRALTEGMRTVASGTAL 302 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 GR+Q + + P I D HN H Y+ ++ A + + V+G ++DKD++ L L Sbjct: 303 QGRWQKLGDKPLTICDTGHNAHGIRYVAEQLAA-TPHRDLYCVLGFVNDKDLSSVL-PLF 360 Query: 347 SVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCG 402 + R A +L E G+ D+V+ A A A ED + + G Sbjct: 361 PKEARYIFTQPGNERALPAGKLAEKAAAYGLRGEVADTVSGALARAREMASEEDMIFIGG 420 Query: 403 SFHTVAHVME 412 S VA V+E Sbjct: 421 SNFVVAEVLE 430 >UniRef50_C2KWA8 Possible tetrahydrofolate synthase n=1 Tax=Oribacterium sinus F0268 RepID=C2KWA8_9FIRM Length = 447 Score = 423 bits (1089), Expect = e-117, Method: Composition-based stats. Identities = 112/428 (26%), Positives = 192/428 (44%), Gaps = 27/428 (6%) Query: 15 SWLSYLENLH---SKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 +W +E L +GL+ + + G + +AG+NGKG+ ++L+ IL Sbjct: 16 TWEECMETLGVNDWYGCKMGLQPTRNLLKKCGNPENKLRFIHIAGSNGKGSVAKSLQQIL 75 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI---SLTYFEYGT 128 +GYK G+Y SPH+ ER + G+ + + ++ + FE T Sbjct: 76 SLSGYKTGMYISPHIEIMNERYTIDGEMISDEDLKRLCLKMRELSESLEEEKPNSFEMLT 135 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDA-DVAVVTSIALDHTDWLGPDRESIGRE 187 A F + +D V+LEVGLGGRLDATN++ +++V+ I L+HT LG E I RE Sbjct: 136 ALAFCYFLEKGVDYVVLEVGLGGRLDATNVIPHKELSVIAHIGLEHTAILGDTLEEIARE 195 Query: 188 KAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGV------EWNYSVTDHDWAFS 239 K GI + P ++ +PE+ I + +EK A L ++ +++ Sbjct: 196 KGGIIAKDTPVVLMHQKPEVMEEIRRICKEKNAKLHITNPKYFHSYSFHIDNGYQYFSYR 255 Query: 240 DAHGTLENLPLPLVPQPNAAT---ALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 + H +L L NA A+ L+ G+ + E+ ++ G+ + PGRF+I+ + Sbjct: 256 ERHEYALSL-LGDYQLDNAMVICDAIDCLKERGISIPEDCVKQGLMTVTWPGRFEILKKR 314 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P +I D AHNP A L ++ L N + ++ DKD L LK+ + Sbjct: 315 PLIILDGAHNPQAVNSLVRSIEMLFPNYKKRIFFSVMADKDYMTMLELLKNNTLSFSFFQ 374 Query: 357 LEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDA---AMADAKAEDTVLVCGSFHTVA 408 +E RG E L + G + +S+ + + A+ + + +L GS + V Sbjct: 375 VESHRGQNPEILKQQWQSHFDGEIRCPESLEEGLEWNLNAVKKEEEKTLLLCLGSLYQVG 434 Query: 409 HVMEVIDA 416 + Sbjct: 435 QIRNFFRN 442 >UniRef50_A6FEP3 Dihydrofolate synthase / folylpolyglutamate synthase n=1 Tax=Moritella sp. PE36 RepID=A6FEP3_9GAMM Length = 441 Score = 423 bits (1088), Expect = e-117, Method: Composition-based stats. Identities = 206/439 (46%), Positives = 269/439 (61%), Gaps = 27/439 (6%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 + + + LA WL YLE++H I++GL R+ VAA L + A V TVAGTNGKG+ Sbjct: 1 MLNSINKSQSLADWLCYLESIHPVNIEMGLGRIGRVAADLALTTFAAKVITVAGTNGKGS 60 Query: 63 TCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLT 122 TC LE IL+ AG+ VGV SSPH+ Y ERVRV G+ L AH SFA IE+ RGD +LT Sbjct: 61 TCAFLERILLDAGFNVGVTSSPHIQDYRERVRVNGKMLTAQAHADSFAFIEAGRGDTTLT 120 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE+ TLS+L LF+ A LDVVILEVGLGGRLDA+NIV ADVAVVT+I +DH DWLG D+ Sbjct: 121 YFEFTTLSSLKLFQDAALDVVILEVGLGGRLDASNIVSADVAVVTTIDIDHADWLGTDKA 180 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 I REKAGIFR+ K AI G PSTIA A+E GA L ++ Y+ W + Sbjct: 181 VIAREKAGIFRAGKKAICGVINPPSTIAAYAEEVGADLIAVNRDYYYTQHADTWDWQSNP 240 Query: 243 GTLEN--------LPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS 294 ++ L +P +P NAATA+AA++A GL V + AI G+ASA LPGR Q + Sbjct: 241 TEQQDASALTFTALEIPQLPLQNAATAIAAIQALGLTVPDTAIHSGVASARLPGRMQQLG 300 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALP----KNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 SP+ DVAHNP +A YL ++ L +++AV+GML DKDIA +LA L V+D Sbjct: 301 TSPQQFLDVAHNPESARYLASQLTRLKQQASSPVKIIAVVGMLKDKDIAASLAALTDVID 360 Query: 351 DWYCAPLEGPRGATAEQLLEHL---------------GNGKSFDSVAQAWDAAMADAKAE 395 W+ A L+G R A +Q+ + L S D++A+AW +A A Sbjct: 361 CWHLAALQGERAAPCQQIEQGLVAAMQQNSKSRDSLRQQPMSHDTIAKAWQSANQSADCN 420 Query: 396 DTVLVCGSFHTVAHVMEVI 414 D ++ GSF TVA +++ I Sbjct: 421 DIIIGFGSFFTVAEIIQHI 439 >UniRef50_Q31HH1 FolC bifunctional folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Thiomicrospira crunogena XCL-2 RepID=Q31HH1_THICR Length = 425 Score = 422 bits (1087), Expect = e-116, Method: Composition-based stats. Identities = 164/426 (38%), Positives = 237/426 (55%), Gaps = 20/426 (4%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P + L W+ +L +LH+ IDLG++RV VA + + P+P V +VAGTNGKG++ Sbjct: 3 PTDTTSLTEWIDWLVSLHADEIDLGIDRVKSVAEAMNLASPSPVVISVAGTNGKGSSVAM 62 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 L SI A+GY+VGVY+SPHL+ + ER+RVQGQ + +FA IE+ARG LTYFE+ Sbjct: 63 LSSIYEASGYQVGVYTSPHLLHFNERIRVQGQLADDQQIVQAFAAIEAARGQTKLTYFEF 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 TL+ALW+F Q LDV++LEVGLGGRLDA N+VDAD +++T+I +DH DWLG DR I Sbjct: 123 STLAALWVFAQHALDVILLEVGLGGRLDAVNLVDADASLITAIGVDHEDWLGSDRNQIAV 182 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG--T 244 EKAGI RS KP I + ++P T+ A + L+R E+ Y D W+F D+ Sbjct: 183 EKAGIMRSGKPTICSDNDIPETLISYASQHNVPLKRLAKEFFYQKNDQAWSFLDSEHKPI 242 Query: 245 LENLPLPLV----PQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQIVS-ESP 297 ++L LP + NAA +A + L VS + + G++ PGR Q + + Sbjct: 243 YQDLALPALSGDFQIQNAAGVVALVETLQSDLPVSFDQLSQGLSDVTHPGRLQKIQFDHQ 302 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 + DVAHNP AA+ L +K A+ +L DKD+ + +K + W A L Sbjct: 303 NWLIDVAHNPQAAQVLAHYLKQASIQAN--AIFSVLQDKDVVPMVEAIKPYIKKWSIADL 360 Query: 358 EGPRGATAEQLLEHL-------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 PR + ++L L N ++++A + + VLV GSF TV+ Sbjct: 361 AVPRALSVDKLERVLLQSGVPSENIVKCSNISEAVAHNRQTSGND--VLVWGSFFTVSQT 418 Query: 411 MEVIDA 416 + Sbjct: 419 LACFQN 424 >UniRef50_C3J886 Folylpolyglutamate synthase n=15 Tax=Bacteria RepID=C3J886_9PORP Length = 441 Score = 422 bits (1086), Expect = e-116, Method: Composition-based stats. Identities = 134/428 (31%), Positives = 194/428 (45%), Gaps = 28/428 (6%) Query: 11 SPLASWLSYL-------ENLHSKTIDLGLERVSLVAARLGVLKPA--PFVFTVAGTNGKG 61 + YL E GLERV +A +G VAGTNGKG Sbjct: 1 MTYQQTIDYLFAATPQFEQQGGSAYKPGLERVLAMAEAIGSPHLGTGIRYIHVAGTNGKG 60 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL 121 +T TL +IL AAGY+ G+++SPHLV + ER+R+ G + E A S Sbjct: 61 STSSTLAAILSAAGYRTGLFTSPHLVDFRERIRIDGMPIEECAVVDFVERTRPLIERFSP 120 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 ++FE TL AL F ++DV I+EVG+GGRLD+TNI+ ++++VT+I+LDHT +LG Sbjct: 121 SFFELTTLMALHHFAAKKVDVAIIEVGMGGRLDSTNIITPELSIVTNISLDHTQFLGSTL 180 Query: 182 ESIGREKAGIFRSEKPAIVGEPEM--PSTIADVAQEKGALLQRR---GVEWNYSVTDHDW 236 E I EKAGIF+ PA+VGE A+ A L V + W Sbjct: 181 EEIAGEKAGIFKPNVPALVGEASASLRPVFRAKAELLDAPLYFAEDSDVLQDAEPDRGGW 240 Query: 237 AFSD-AHGTLENLPLPLVPQPNAATALAALRAS---GLEVSENAIRDGIASA----ILPG 288 +GTL + NA T LAAL ++ A+ +G A L G Sbjct: 241 LLHTRDYGTLWGELGGAAQRLNARTILAALSILARQSFQIPRVAVEEGFAHVVERSHLLG 300 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 R+Q V+ P D HN + ++K + + V GM+ DKD L L Sbjct: 301 RWQKVASQPDTYCDTGHNEAGICLVVEQLKQ-EQYQALHIVFGMVADKDWHSVLR-LLPT 358 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSF 404 +Y R ++E+L + G F S+ + AA +A +D + + GS Sbjct: 359 SAHYYFVQPTSDRALSSEELAQEARSIGLEGSVFPSIEEGCLAAQKEALPQDLIYIGGSN 418 Query: 405 HTVAHVME 412 + VA ++ Sbjct: 419 YVVAEALK 426 >UniRef50_UPI0001BC3950 FolC bifunctional protein n=1 Tax=Butyrivibrio crossotus DSM 2876 RepID=UPI0001BC3950 Length = 428 Score = 422 bits (1086), Expect = e-116, Method: Composition-based stats. Identities = 124/426 (29%), Positives = 194/426 (45%), Gaps = 22/426 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 YL+++ GL + + L + V +AGTNGKG+T ++ I Sbjct: 1 MDYCDVQKYLDSVGRMGSVPGLTAIKALLLELKNPEKNLKVIHIAGTNGKGSTGAFIDKI 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-----DISLTYFE 125 L G G YSSP ++ E +R+ G+ + + E+++AR +I T FE Sbjct: 61 LTNTGLTTGRYSSPAVMEPLEIIRINGKNIGCEDFSEVVTEVKAARERLAEDNIYPTRFE 120 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESI 184 T SA F + ++DV I+E G+GG LDATN+ + + +V+TSI++DHTD+LG E I Sbjct: 121 VETASAFLFFSRKKVDVAIIECGMGGLLDATNVFEEVLCSVITSISMDHTDFLGDTLEKI 180 Query: 185 GREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 KAGI + P + + + I A K A L + + ++ Sbjct: 181 AFNKAGIIKDHCPVVTCNRDEAVAKVIEQEAALKKAPLIQVKDAVLSEIGSQGPELIFSY 240 Query: 243 GTLENLPLPLVPQP---NAATALAALRAS---GLEVSENAIRDGIASAILPGRFQIVSES 296 ENL L NAA A+ A++ G +S++ IRDGI + PGRF+I+ + Sbjct: 241 EEYENLKCGLKGIYQTVNAAAAIEAVKVLKNSGYGISDDNIRDGIENTYWPGRFEIIHNN 300 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P VI D AHNP A L+ ++ N + +IG+ DKDI G L + + D+ Sbjct: 301 PLVITDGAHNPDGARALSETLRYYFGNKKHTFLIGIFKDKDIYGILDEIMDLADNVIVIE 360 Query: 357 LEGP-RGATAEQLLEHLG-----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 G R A E + + N + F V + D+V+ GS + + Sbjct: 361 TPGNIRAADCEHVASIIKERYSINAEPFKDVKDGVLRCLELCT--DSVVTFGSLSNIKRI 418 Query: 411 MEVIDA 416 E+I Sbjct: 419 KEIIKN 424 >UniRef50_UPI00016C3FCF FolC bifunctional protein n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C3FCF Length = 437 Score = 422 bits (1085), Expect = e-116, Method: Composition-based stats. Identities = 124/435 (28%), Positives = 188/435 (43%), Gaps = 31/435 (7%) Query: 11 SPLASWLSYLENLHSKTI------DLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 L++ + + DL LER+ + RLG + + V GT GKG+TC Sbjct: 1 MTYDEALAFWYGRINYEVRSAGPLDLKLERMRALLRRLGDPQDRLRLVHVTGTKGKGSTC 60 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI----- 119 LES+L AGY+ G+++SPHL ER++V + A E+ A + Sbjct: 61 AMLESVLRTAGYRAGLFTSPHLAHIEERMQVDRVPISHGELAACMEEVAPAVRAMETDPR 120 Query: 120 --SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWL 177 S T+FE GT F + + D+ ++EVGLGGR D+TN+ V+V+T++ DH L Sbjct: 121 FPSPTFFEIGTALGFLHFVRRRCDIALIEVGLGGRFDSTNVCQPLVSVITNVGPDHMAQL 180 Query: 178 GPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT--D 233 G E+I +KAGI + P + G + + I VA E A + GV+ + Sbjct: 181 GTTLEAIAFQKAGIIKRRVPVVSGVTQDGPRAVIRQVAAELSAPIWEVGVKPCSPIPSFK 240 Query: 234 HDWAFSDAHGTLENLPLPLVPQPNAATALAA------LRASGLEVSENAIRDGIASAILP 287 + + P+ L+ A A A LR +G+ + A+ G+ P Sbjct: 241 REELHVAEEVGVRAAPIGLLGAHQRANAAVATAVLDRLRTAGMHIPAAAVARGLGEVKWP 300 Query: 288 GRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKN-GRVLAVIGMLHDKDIAGTLAWLK 346 R ++V E P I D AHN +AE L ++ N G V + DK A L L Sbjct: 301 ARVEVVRERPTTILDTAHNVPSAEALVTTLREAFPNAGTKRVVFAVSSDKQFAEILRVLA 360 Query: 347 SVVDDWYCAPL-EGPRGATAEQLLEHLGNGKS------FDSVAQAWDAAMADAKAEDTVL 399 S D +Y PRG E L L + +AW+AA++ D V Sbjct: 361 SYFDHFYFTKYSNNPRGVPTEALATALAAVAPGKPFTLHATAPKAWNAAVSTVTDTDLVC 420 Query: 400 VCGSFHTVAHVMEVI 414 V GS + ++ Sbjct: 421 VTGSVFLAGELRPLM 435 >UniRef50_C6LLD0 Tetrahydrofolate synthase n=3 Tax=Clostridiales RepID=C6LLD0_9FIRM Length = 437 Score = 422 bits (1085), Expect = e-116, Method: Composition-based stats. Identities = 127/431 (29%), Positives = 196/431 (45%), Gaps = 21/431 (4%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 A +YL LGLE + + + LG + +AGTNGKG+ + Sbjct: 2 TAMDYTEARAYLAEAAKSGSVLGLEAMRALLSELGDPQDKLKFIHIAGTNGKGSVLAYVS 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LT 122 +IL AGY+VG Y SP L Y ER++V + + A T + A G + T Sbjct: 62 TILKEAGYRVGRYISPTLFSYRERIQVNEIYITKEALTEHTFRVREAVGRMKAAGNPLPT 121 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDR 181 FE T A F Q D+V+LE G+GG DATN V V ++TSI++DH +LG Sbjct: 122 VFEIETAIAFLYFVQEDCDIVVLETGMGGDTDATNAVQTTVLEILTSISMDHMQFLGNSL 181 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS 239 I KAGI + + + EPE I ++A + A L+ V +A Sbjct: 182 AEIAAHKAGIIKPDTVVVSAAQEPEAMRVIEEIAAGQRAQLRIADAGRAEEVAYGLFAQR 241 Query: 240 DAHGTLENLPLPLVPQPNA------ATALAALRASGLEVSENAIRDGIASAILPGRFQIV 293 + G +NL + L A+ AL+ G ++E +R G+A + GRF ++ Sbjct: 242 FSCGGYKNLEIRLAGTYQIANAVVAVEAVRALQELGFRITEEQLRQGLAKTVWRGRFTVI 301 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 + P I D AHN AAE L +K R++AV G+L DK+ L +D Sbjct: 302 CDEPLFIVDGAHNRGAAEQLRESIKTYLAGRRIIAVCGVLKDKEYEAVLQITAPYIDRMI 361 Query: 354 CA-PLEGPRGATAEQLL----EHLGNGKSFDSVAQAWDAAMADAK-AEDTVLVCGSFHTV 407 + PR AE+L +++ + ++ +S+AQA D + + A D +L GS + Sbjct: 362 TIETPDNPRALPAEELARTAQKYIPHVEAAESLAQAVDRSFSAADREGDVILAFGSLSYL 421 Query: 408 AHVMEVIDARR 418 +++ + R Sbjct: 422 GEMIKETEKWR 432 >UniRef50_B6JCP5 FolC bifunctional protein n=17 Tax=Alphaproteobacteria RepID=B6JCP5_OLICO Length = 442 Score = 422 bits (1085), Expect = e-116, Method: Composition-based stats. Identities = 136/435 (31%), Positives = 192/435 (44%), Gaps = 25/435 (5%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKG 61 + A L L+ L LH K IDL L R+ + L + V VAGTNGKG Sbjct: 1 MSAAQPAPRKLDDLLARLAALHPKRIDLDLSRMHRILEALDHPERRLPPVIHVAGTNGKG 60 Query: 62 TTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL 121 +T L +I AAG +V VY+SPHLVR ER R+ G+ ++ +FA E A G + Sbjct: 61 STVAFLRAICEAAGLRVHVYTSPHLVRLNERFRIAGELASDAQLEDAFARCERANGGAPI 120 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPD 180 T FE T +A LF Q DV++LEVGLGGRLDATN+V+ +V+T + LDH ++LG Sbjct: 121 TLFEIETAAAFLLFSQHIADVLLLEVGLGGRLDATNVVETPLASVITPVGLDHFEFLGDT 180 Query: 181 RESIGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF 238 I EKAGI + P IV E E + I A++ A L EW+ V + Sbjct: 181 LIKIATEKAGIIKRNVPVIVAEQQAEAQAVIEQTARKMRAPLFCATQEWHVGVEHGRLVY 240 Query: 239 SDAHGTLENLPLPLVPQP---NAATALAALRASG-LEVSENAIRDGIASAILPGRFQIV- 293 D G L+ L + NA A+A LRA L + A G+ SA P R Q + Sbjct: 241 HDERGLLDVTAPRLFGRHQFDNAGLAIATLRAIPSLAIEPAAFEQGVVSAQWPARMQRLP 300 Query: 294 --------SESPRVIFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLA 343 + + D HN + L + V+ ++GM+ +KD LA Sbjct: 301 AGTLATLAPQGCELWLDGGHNADGGRVAAAALADLGERVERPVVLIVGMMGNKDARAFLA 360 Query: 344 WLKSVVDDWYCAPL-EGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADA-KAEDT 397 + P+ + E L V +A + A + Sbjct: 361 NFSGLTRHVLAVPILDNDNAMEPEALAAVARSLDLRADVMPGVTEALARLASLAYETPPR 420 Query: 398 VLVCGSFHTVAHVME 412 +L+ GS + HV+ Sbjct: 421 ILITGSLYLAGHVLA 435 >UniRef50_Q1GD59 FolC bifunctional protein n=6 Tax=Alphaproteobacteria RepID=Q1GD59_SILST Length = 423 Score = 422 bits (1085), Expect = e-116, Method: Composition-based stats. Identities = 139/419 (33%), Positives = 195/419 (46%), Gaps = 25/419 (5%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCRTLESILM 72 + L+ + LH K IDL L+RV + A L + V +AGTNGKG+T + + L Sbjct: 7 DAILARMMALHPKIIDLTLDRVWRLLAALENPQDKLPPVIHIAGTNGKGSTQAMIRAGLE 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 G V Y+SPHL R+ ER+R+ G + E+ T E SA GD S+TYFE T++ L Sbjct: 67 GWGKSVHAYTSPHLARFHERIRLAGDLISEAHLTEVLDECYSANGDASITYFEITTVAGL 126 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F + D +LEVGLGGRLDATN++ +V+V+T +++DH +LG I EKAGI Sbjct: 127 LAFSRTPADYTLLEVGLGGRLDATNVITPEVSVITPVSIDHEQFLGNTLAKIAGEKAGII 186 Query: 193 RSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 + P +VG E I D A GA L G W+ + D G L +LPL Sbjct: 187 KRGVPVVVGPQAEEAMEVIEDTAMRLGAPLIAYGQHWHVHEERGRLVYQDERGLL-DLPL 245 Query: 251 PL----VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV------- 299 P NA ALA LR G E A + A P R Q + P V Sbjct: 246 PNLMGAHQIQNAGAALAVLRHLGA--DEAACEAAVVGAQWPARMQRLKTGPLVEIAGAAE 303 Query: 300 -IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 D HN A L + L + GML+ KD+ G L L + + Sbjct: 304 LWLDGGHNAAAGIALADVLAKL-PKRPTHLICGMLNTKDVTGYLRPLAAEAQSLTAVSIP 362 Query: 359 GPRG-ATAEQLLEHLGNG----KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 G +AE+ + + +SVA+A A +A + VL+CGS + +++ Sbjct: 363 GEAATLSAEETKAAASSVDLPATTAESVAEALTAILAR-DPDSRVLICGSLYLAGNILR 420 >UniRef50_A0YB05 FolC bifunctional protein n=1 Tax=marine gamma proteobacterium HTCC2143 RepID=A0YB05_9GAMM Length = 428 Score = 420 bits (1080), Expect = e-116, Method: Composition-based stats. Identities = 165/422 (39%), Positives = 242/422 (57%), Gaps = 15/422 (3%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 L WL + E+ HS I+LGLERV VA +G+ V TVAGTNGKG+T L + Sbjct: 3 FDTLNEWLVWQESCHSSEIELGLERVGAVARAMGLTLDRSKVITVAGTNGKGSTVAVLNT 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 +L +AGY V ++SPH +RY ER+++ ++ + SF I+ ARG I LT+FE+GTL Sbjct: 63 LLRSAGYSVACFTSPHFLRYNERIKLDDCDVSDQLLIESFDRIDQARGTIPLTFFEFGTL 122 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +A+ + + DV++LEVGLGGRLDA NI+DAD+AV+TSI +DH DWLG DRE IGREKA Sbjct: 123 AAIDICQHHNADVILLEVGLGGRLDAVNIIDADIAVITSIDIDHEDWLGSDREQIGREKA 182 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYS--VTDHDWAFSDAHG---- 243 GI RS KP + P+++ A + G + + G ++ Y W +S Sbjct: 183 GIMRSGKPTVSAGLTPPASLQIEADKIGTTIYQAGRDFMYRQAREHGRWNWSGQSIDGQP 242 Query: 244 -TLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQ-IVSESPRVIF 301 L L P +P + + AL L+ L +++ + +A+ L GRFQ V E +V+ Sbjct: 243 VELLALQFPSLPAESVSAALQTLQLLDLPITKID-YNSLANVDLTGRFQCRVIEGKQVVL 301 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGP 360 DVAHNP AA YL R++ GR +A++ ++ DKDI G + L + D WY L + P Sbjct: 302 DVAHNPAAASYLAKRLQQTHGVGRTIALVAVMADKDIDGIVEPLINSFDTWYALELADVP 361 Query: 361 RGATAEQLLEHLG-----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 R A L + + + ++A A+ A++ + ED ++V GSF TVA ++E D Sbjct: 362 RAMKASALAKKISSLTDVDVHVSSTIAIAFSDALSMMEKEDRLVVFGSFFTVAGLLEFAD 421 Query: 416 AR 417 + Sbjct: 422 GK 423 >UniRef50_Q3B220 Folylpolyglutamate synthetase n=8 Tax=Chlorobiaceae RepID=Q3B220_PELLD Length = 443 Score = 419 bits (1079), Expect = e-116, Method: Composition-based stats. Identities = 134/445 (30%), Positives = 205/445 (46%), Gaps = 30/445 (6%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNG 59 + + R P L +L LH I GLERV ++ G + + V VAGTNG Sbjct: 4 ITVSRYP---VTYQETLDFLFPLHRFGIKPGLERVRMLLQAAGSPERSLGMVVHVAGTNG 60 Query: 60 KGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI 119 KGT + S+ AAG K +Y+SPHLV +TER+R+ G+ +PE A ++ A + Sbjct: 61 KGTAASAMASMFTAAGKKTALYTSPHLVDFTERIRIDGRRIPEDAAARYATLLKPAALEH 120 Query: 120 SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGP 179 T+FE T A F ++V +LE G+GGRLDATN+V++D AV+T I LDHT+WLG Sbjct: 121 QSTFFEVTTAIAFAWFADCGVEVSVLETGMGGRLDATNVVESDYAVLTRIGLDHTEWLGS 180 Query: 180 DRESIGREKAGIFRSEKPAIV--------GEPEMPSTIADVAQEKGALLQRRGVEWNY-- 229 +I EKA I + G+ E + D AQ GA LQ G ++++ Sbjct: 181 TISAIAGEKAAIIKPSSRVFTSINPDADPGQSEAFGPVRDAAQGCGAPLQVVGRDFSFGG 240 Query: 230 ---SVTDHDWAFSDAHGTLENLPLPLVPQPNA---ATALAALRASGLEVSENAIRDG--- 280 A + L +P+ +A ATA+A +G V A+R+G Sbjct: 241 VVAEPGLLQLDVVTASCHYKGLRVPVTGAFHAPGIATAVAVAEDAG--VGPEAVREGLDA 298 Query: 281 IASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKA-LPKNGRVLAVIGMLHDKDIA 339 +AS GR +++ P DV+HN + L + + G++ DKD Sbjct: 299 LASTGYRGRLELLGHRPDTFLDVSHNADGMRATVDALMPFLSRYRDARVLFGLVSDKDSE 358 Query: 340 GTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAE 395 + L + + L RG +E+L E +F S +A +A + Sbjct: 359 SMIRELMRLRCRFATTGLPSERGVASEELAEICRGLGAEAVAFSSPPEALQFLREEASPD 418 Query: 396 DTVLVCGSFHTVAHVMEVIDARRSG 420 +L+ GSF+ ++E A ++G Sbjct: 419 SLILITGSFYLAGALLEKGTAGKAG 443 >UniRef50_A5FMS8 FolC bifunctional protein n=21 Tax=Bacteroidetes RepID=A5FMS8_FLAJ1 Length = 408 Score = 419 bits (1079), Expect = e-116, Method: Composition-based stats. Identities = 121/420 (28%), Positives = 193/420 (45%), Gaps = 30/420 (7%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 + + + + L + + L + L+A LG + VAGTNGKG+T Sbjct: 2 NYQETTNWMFNQLPMYQLQGASAYKEDLTNIKLLAEHLGNPEKKLQTIHVAGTNGKGSTS 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L S+L AGYKVG+Y+SPHL + ER+++ GQE+ E A+ + +++F Sbjct: 62 HMLASVLQEAGYKVGLYTSPHLKDFRERIKINGQEITEDFVCEFIAKHKDFFEANDMSFF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E A F + D+ I+EVGLGGRLDATNI+ V+V+T+I LDHT +LG E+I Sbjct: 122 EMSVGLAFDYFAAEKTDIAIIEVGLGGRLDATNIITPLVSVITNIGLDHTQFLGNTLEAI 181 Query: 185 GREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 EKAGI + P ++GE PE A+ A + + Sbjct: 182 AGEKAGIIKPNVPVVIGEYTPETQPVFLAKAEANKAPIYFASDLISEVFPSD-------- 233 Query: 243 GTLENLPLPLVPQPNAATALAAL----RASGLEVSENAIRDGI----ASAILPGRFQIVS 294 + N T + + ++S+ ++ G+ + L GR+Q + Sbjct: 234 ------LIGDYQFHNKKTVQQTIKIVNETTDFKISDENLKSGLLNTVKNTGLQGRWQQLG 287 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 E+P+++ D AHN H + +++ K ++ V+G+++DKD+ L L +Y Sbjct: 288 ENPKIVCDTAHNKHGLSVVMNQLRN-EKYEKLHIVLGVVNDKDLDSIL-PLFPKEAQYYF 345 Query: 355 APLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 RG E L N G+ +DSV A+ A +A D + V GS VA + Sbjct: 346 CSPNSSRGLPTEVLQNAAKNFGLIGEKYDSVESAFAKAKQNASKNDFIYVGGSTFVVAEL 405 >UniRef50_B4VMJ0 FolC bifunctional protein n=2 Tax=Cyanobacteria RepID=B4VMJ0_9CYAN Length = 451 Score = 419 bits (1078), Expect = e-115, Method: Composition-based stats. Identities = 122/437 (27%), Positives = 195/437 (44%), Gaps = 48/437 (10%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 L+ + LGLER+ + A LG + VAG+NGKG+ C L S+L AGY+VG Sbjct: 16 LQPYQRFGVHLGLERIQRLLAALGNPHQRIPMIHVAGSNGKGSVCAYLSSVLSEAGYRVG 75 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR---GDISLTYFEYGTLSALWLFK 136 Y+SPHL+ +TER+ + + + ++++A + S T FE T +A F Sbjct: 76 RYTSPHLIDWTERICINQYPISTAELVNVLEQVQAAVPPDSEESPTQFEVITAAAWLYFA 135 Query: 137 QAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 Q Q+D+ ++EVGLGGRLDATN+ D ++TSI+ +H LG I EKAGI ++ Sbjct: 136 QKQVDIAVIEVGLGGRLDATNVCDQPLATIITSISREHWQVLGSTLSQIATEKAGILKAN 195 Query: 196 KPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVT--------------------- 232 PAI+ PE + + ++ + ++ Sbjct: 196 CPAIIAPLPPEAKAVVQSRIEQLNCPVTWVEPAQKFNRQTVVRAGFEPRLSSIATPKSLN 255 Query: 233 -------DHDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS---GLEVSENAIRDGIA 282 D S A T L + N+A A+A ++ G ++ ++AI G+A Sbjct: 256 PPLHQNADAPLWASYAGITYPLPLLGEIQLTNSAVAIATFQSLIRQGWQIPDSAIVSGMA 315 Query: 283 SAILPGRFQIVS-ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGT 341 GR Q ++ R++ D AHNP AA L + L N V V+G+L K+ G Sbjct: 316 KTQWLGRLQWTEWKNYRLLVDGAHNPAAATALREYVDTL--NTPVTWVMGILSTKEHEGI 373 Query: 342 LAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG-------NGKSFDSVAQAWDAAMADAKA 394 L D Y P+ A E+L + ++ ++ A A Sbjct: 374 FRALLRGGDRVYLVPVPDHSSAEPEELSAIARSVCPTLADCHTYPNLEAGLQA-ATATAA 432 Query: 395 EDTVLVCGSFHTVAHVM 411 + T+++CGS + V + + Sbjct: 433 DSTIVLCGSLYLVGYFL 449 >UniRef50_Q7NLP7 Folylpolyglutamate synthase n=1 Tax=Gloeobacter violaceus RepID=Q7NLP7_GLOVI Length = 413 Score = 419 bits (1078), Expect = e-115, Method: Composition-based stats. Identities = 135/408 (33%), Positives = 200/408 (49%), Gaps = 22/408 (5%) Query: 19 YLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKV 78 YL++L + LGLER+ + RLG + A VAGTNGKG+ C L IL AGY+ Sbjct: 6 YLDHLQKFGVHLGLERIQALLKRLGEPQVAFQAVHVAGTNGKGSVCAYLSHILQTAGYRT 65 Query: 79 GVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-----LTYFEYGTLSALW 133 G Y+SPHL+ + ER+ + G + + A A A+++++ + T FE T +A Sbjct: 66 GRYTSPHLLDWNERIWIDGAFISDGALQACLAKVKASAEHLPKSLGEPTQFEIVTAAAFL 125 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 F Q+ ++V ++EVGLGGRLDATN+ + +V+T I LDH D LG +I EKAGI Sbjct: 126 HFAQSAVEVAVVEVGLGGRLDATNVFEQPPASVITGIGLDHCDQLGSTLAAIAAEKAGIL 185 Query: 193 RSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 RS P + PE + + A G ++ + + W G LPL Sbjct: 186 RSGCPLVCAPLAPEAMQVVTEKALALGVVITLAEPAHEVAPGEAQW-----QGFRYRLPL 240 Query: 251 -PLVPQPNAATALA---ALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 V N+ATALA LR GL + E AIR G+ + + PGR+Q + E R++ D AHN Sbjct: 241 AGGVQLQNSATALATCQVLRERGLPIDETAIRTGLENTVWPGRYQWLGE--RLLLDGAHN 298 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 +A YL + L + ++G+L KD L L D + P+ R E Sbjct: 299 EDSAVYLRRYLDTLHPKESIRWIVGILESKDARAVLKALLRPGDAFVAVPVPDARSHPPE 358 Query: 367 QLLEHLGNGKSFDSVAQA--WDAAMADAKAEDTVLVCGSFHTVAHVME 412 +L S+A A + A+ + E ++ GS + V+ Sbjct: 359 RLASMAQTMG-IHSIASASGFSEALQLSDTEQLTVIAGSLYLAGAVLR 405 >UniRef50_UPI0001C16345 Folylpolyglutamate synthetase n=2 Tax=Nostocaceae RepID=UPI0001C16345 Length = 471 Score = 419 bits (1078), Expect = e-115, Method: Composition-based stats. Identities = 124/456 (27%), Positives = 197/456 (43%), Gaps = 46/456 (10%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 TP P + S L+ L ++LGL R+ + L + VAGTNGKG+ C Sbjct: 14 STP-HLVPYYAVDSLLQPLKHFGVNLGLNRIVKLLETLNNPHRQVPIIHVAGTNGKGSVC 72 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR--GDISLT 122 L SIL +GYK G Y+SPHL+ + ER+ + + + T ++ + T Sbjct: 73 AYLSSILTESGYKTGRYTSPHLIDWNERICINEKPIASEELTRLIEIVKGVINSNEDQPT 132 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDR 181 FE T ++ F Q ++D+ ++EVGLGGRLDATN+ D V V+TSI DH LG Sbjct: 133 QFEIITAASWLYFAQEKVDIAVVEVGLGGRLDATNVCDHPLVTVITSIGRDHWQQLGSSI 192 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS 239 I REKAGI ++ P ++G + + + E + + S ++ Sbjct: 193 SDIAREKAGIIKAGCPVVMGKLPEDAKRAVICRSIELESPIFVVSPAREISPGWAEYQTV 252 Query: 240 DAHGTLENLPLPL-----VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQ 291 G ++ + PL + N+A ALA+ L+ G E+S AI G+ PGR Q Sbjct: 253 GPGGRIKAIKYPLPLKGQIQLTNSALALASLGMLQRQGWEISGQAIIRGMEKTKWPGRMQ 312 Query: 292 IV-----SESPRVIFDVAHNPHAAEYLTGRMKAL-PKNGRVLAVIGMLHDKDIAGTLAWL 345 + +++ D AHNP +A+ L + ++ +N + V+GML KD L Sbjct: 313 WFNWKKDNSDCQLLIDGAHNPESAQVLRNYVDSIGDRNKNITWVMGMLTTKDHKDIFREL 372 Query: 346 KSVVDDWYCAPLEGPRGATAEQLLEHLGN-------GKSFDSVAQAWDAAMADAKA---- 394 D Y P+ G A + L ++ + A +AA + Sbjct: 373 LKTKDRLYLVPVPGSDYANLDYLKTLALETCPDLDFCAIYEDIFLALNAAFNNFNNTNNN 432 Query: 395 ---------------EDTVLVCGSFHTVAHVMEVID 415 V++CGS + + H ++ Sbjct: 433 TNNNTNNNTNNNTNINGPVILCGSLYLIGHFFSQVN 468 >UniRef50_Q1IVH6 FolC bifunctional protein n=2 Tax=Acidobacteria RepID=Q1IVH6_ACIBL Length = 447 Score = 418 bits (1076), Expect = e-115, Method: Composition-based stats. Identities = 121/446 (27%), Positives = 187/446 (41%), Gaps = 39/446 (8%) Query: 11 SPLASWLSYLENLHSK-----TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 + + L L + + L + ++ L + +AGTNGKG+T Sbjct: 1 MTYETAVEALYQLGHELAGTPSHKFDLAHMRVLLDALAHPERRFASVLIAGTNGKGSTAA 60 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------ 119 TL SIL+AAGYK G+Y+SPHLV+ ER R+ G ++ ++ TA++ +E+ + Sbjct: 61 TLSSILLAAGYKTGLYTSPHLVKINERFRINGSQVNDAEFTAAYEHVETLASALVETKAL 120 Query: 120 --SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWL 177 ++FE T A LF +A + + +LEVG+GGRLDATN+V+ ++V+ I+LDH +L Sbjct: 121 PWHPSFFEMLTAMAFELFARAGIQIAVLEVGMGGRLDATNVVEPLISVIADISLDHQKFL 180 Query: 178 GPDRESIGREKAGIFRSEKPAIVGEPEMP-------STIADVAQEKGALLQRRGV----- 225 G I EKAGI + + + + A+ A+ + Sbjct: 181 GNTIAEIAAEKAGIIKPNGTVVTLPQHPAANDVIGHAILDHQAKGISAVKHMPPMAPGSA 240 Query: 226 EWNYSVTDHDWAFSDAHGTLE-NLPLPL-VPQPNAATALAA---LRASGLEVSENAIRDG 280 ++ + + + +E N PLP N A A+ L G V+ I G Sbjct: 241 DYRDVEGRNRYPLEVMNEIIEVNSPLPGRHQLRNLALAITTAEELARFGFPVTSKQIEQG 300 Query: 281 IASAILPGRFQIVSE-----SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHD 335 I GRFQ++S +IFDVAHNP A L + + V G +HD Sbjct: 301 IRETRWAGRFQVISAEKNALKRELIFDVAHNPDGAWALRSALSDKIAERPLTLVFGAMHD 360 Query: 336 KDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKS----FDSVAQAWDAAMAD 391 K + L + PR AT +L E + SV A A Sbjct: 361 KAFREMVQILFPTAQQVIVTQAKNPRAATTAELAEVAKEVGTEVVQCASVEAAVHKAPEL 420 Query: 392 AKAEDTVLVCGSFHTVAHVMEVIDAR 417 ++V GS V M + Sbjct: 421 TAENGVIVVTGSIFVVGEAMNALQVE 446 >UniRef50_D1AJ52 FolC bifunctional protein n=1 Tax=Sebaldella termitidis ATCC 33386 RepID=D1AJ52_SEBTE Length = 407 Score = 417 bits (1074), Expect = e-115, Method: Composition-based stats. Identities = 109/404 (26%), Positives = 189/404 (46%), Gaps = 11/404 (2%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 L+++ I LGLE + LG + + +AGTNGKG+ LE+ L+ AGYK Sbjct: 5 KKLDSIDKNKIKLGLETMEKSLKILGNPERNYKIIHIAGTNGKGSAAAFLEAGLIEAGYK 64 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG--DISLTYFEYGTLSALWLF 135 G Y+SP + R+ ER+ + +E+ + + ++ A DI LTYFE T Sbjct: 65 TGKYTSPEIYRFNERITINREEISDGDVELYYEKVNKALELSDIKLTYFEITTAMMFLYM 124 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 K +D ++LE GLGGR DATN V ++++T+++ DH ++LG I EKAGI + + Sbjct: 125 KDKNIDYLVLETGLGGRTDATNTVTPVISLITNVSFDHMEFLGNTLREIAHEKAGIIKKD 184 Query: 196 KPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPLV 253 P + PE+ I + +L++ N + D + + + L L Sbjct: 185 IPVFFADDNPELLEEIKAKTENYINVLKKYEFNENSTKLDKEKLNTLVKINNKEFRLSLF 244 Query: 254 PQPNAATALAALRASGLE-VSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEY 312 + L A A + + I+ + + GRFQI +E+P +I D AHN +A Sbjct: 245 GKFQGKNFLLAYEALKYLGIDDEVIKRACSETVWNGRFQIAAENPFIILDGAHNKDSAAV 304 Query: 313 LTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL---- 368 L+ ++ + N ++ +I +L DKD L L D + RG + +++ Sbjct: 305 LSESLREVFPNKELVYIISILRDKDNESILEELAKASDYAVFTGINNNRGQSCDEMYNKG 364 Query: 369 LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 ++ + + ++ A A++ K ++CGSF + + Sbjct: 365 KKYFKHSYAENTPESALKKAVSLNKK--ATVICGSFLLLKEYKK 406 >UniRef50_Q2SJC8 Folylpolyglutamate synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SJC8_HAHCH Length = 430 Score = 417 bits (1074), Expect = e-115, Method: Composition-based stats. Identities = 167/413 (40%), Positives = 237/413 (57%), Gaps = 13/413 (3%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARL-GVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 L+ WL Y+ LHS+ I++GL+RV+ V RL + A V T+AGTNGKG+T +E++ Sbjct: 6 LSDWLDYVSQLHSQVIEMGLDRVNDVFRRLCRNARLAKTVVTIAGTNGKGSTLAAVEALA 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 +AAG VG Y+SPH++R+ ERVR+ G ++ + A A+FA +ESARG +LTYFE+ TL Sbjct: 66 LAAGKTVGAYTSPHILRFNERVRINGVDVSDEALEAAFAAVESARGQTALTYFEFTTLVG 125 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 +LF+QA+LD+V+LEVGLGGRLDA NIVD D+AV+TS+ LDH +WLG RE IGREKAGI Sbjct: 126 FYLFQQARLDLVLLEVGLGGRLDAVNIVDPDLAVITSVDLDHQEWLGESREDIGREKAGI 185 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD---HDWAFSDAHGT---- 244 R P I+ E P+++ DVA + G ++ T + Sbjct: 186 LRPGIPLIIAEEAPPTSVVDVAGKLGCATFIWRQDFTLERTGDASQALQWRGRRKHADIV 245 Query: 245 LENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 ++ L +P N A A+ +SE+ + IA +PGRFQ++ P V DV Sbjct: 246 VDGLSDNGLPMANMAAAMQVAMLLDFPLSESQVAAVIAGVKVPGRFQLLRRDPEVYADVG 305 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 HNPHAA YL + LP +AV L DKD+AG + L V D W PL R Sbjct: 306 HNPHAARYLKQWLGGLPVKKPQIAVFSALKDKDVAGIVKELAGVFDRWIVFPLNVDRAMP 365 Query: 365 AEQLLEHLGNGKSFD-----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 QL E + +S S+++ A ++A ++ ++ GSF TVA + + Sbjct: 366 LAQLAELVERNQSAPLQTCASLSECLAQATSEAGSDGRIVAFGSFFTVAEIFQ 418 >UniRef50_C4LJV2 Dihydrofolate synthase / folylpolyglutamate synthase n=68 Tax=Actinomycetales RepID=C4LJV2_CORK4 Length = 538 Score = 417 bits (1073), Expect = e-115, Method: Composition-based stats. Identities = 129/467 (27%), Positives = 199/467 (42%), Gaps = 53/467 (11%) Query: 6 TPQAASPLASWLSYLENLHS-KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 TP LA L + ID L R+ V LG + A VAGTNGK + Sbjct: 72 TPDDLEALADVEDQLNSRWPETKIDPTLYRMHQVLDLLGDPQHAYPSIHVAGTNGKTSVT 131 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA--------- 115 R +ES+L A + G +SPHL TER+ + G+ + + ++ I+ Sbjct: 132 RMIESLLRAFHRRTGRTTSPHLQSVTERIAIDGEPIHPADFVQTWKSIKPFVEMVDRRSE 191 Query: 116 -RGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHT 174 G ++ FE T A F A +DV ++EVG+GGR DATN+V DV V+T + +DH+ Sbjct: 192 DEGGPRMSTFEVLTTMAFAAFADAPVDVAVVEVGMGGRWDATNVVHGDVTVITPVGMDHS 251 Query: 175 DWLGPDRESIGREKAGIFR-----------SEKPAIVGEPE--MPSTIADVAQEKGALLQ 221 ++LG E I EKAGI + + AI+ E + + I + A A + Sbjct: 252 EYLGDTIEEIAGEKAGIIKSRWDKDDLLTPPDNVAIIAEQDPAAMNVILEQAVSVDASVA 311 Query: 222 RRGVEW-----NYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS-------- 268 R G E+ + +V GT EN+ LPL A A AL A Sbjct: 312 RAGSEYGVVERSVAVGGQTLTIRGLGGTYENIFLPLSGAYQARNAATALAAVEAFFGAGG 371 Query: 269 GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLA 328 G ++ N +R+G + P R + + SP V D HNP A L + R++ Sbjct: 372 GRQLDINTVREGFGNVSSPARLERIRTSPSVFVDATHNPQGARALAETLHDDFSFRRLIG 431 Query: 329 VIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG------NGKSFDSVA 382 ++ + DKD+ G L L+ D+ ++ PR ++L E S+A Sbjct: 432 IVSIFQDKDVVGVLETLRDTFDEIVVTEVDSPRAMPVDELAELARTLFGDERVHVSASMA 491 Query: 383 QAWDAAMADAKAEDT----------VLVCGSFHTVAHVMEVIDARRS 419 A + A+A A+ E V++ GS ++ ++ Sbjct: 492 DAIEDAVALAEEEGEEEGYGLAGTGVVITGSVYSAGRARALLGKEPE 538 >UniRef50_D2RA71 Bifunctional protein FolC n=3 Tax=Bifidobacteriaceae RepID=D2RA71_GARVA Length = 485 Score = 417 bits (1072), Expect = e-115, Method: Composition-based stats. Identities = 117/433 (27%), Positives = 192/433 (44%), Gaps = 44/433 (10%) Query: 26 KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPH 85 +L L+R+ L+ LG + + V + GTNGKG+T R ESI A G + G+Y+SPH Sbjct: 28 NKTNLDLDRMRLILDILGHPEQSMRVIHITGTNGKGSTARMAESICRAYGLRTGLYTSPH 87 Query: 86 LVRYTERVRVQGQELPESAHTASFAEIE----------SARGDISLTYFEYGTLSALWLF 135 L R ER+ + GQE+ ++ + +++ A G +++FE T A+W F Sbjct: 88 LERVNERIMIDGQEISDNQFVDVWDQMKDIIDMVDARMEADGKPKMSFFEVLTAMAIWAF 147 Query: 136 KQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSE 195 A +DV ++EVG+GG DATN+++AD A++ + +DH WLG E I R KAGI + Sbjct: 148 ADAPVDVAVMEVGMGGEWDATNVMNADAAIIGPVDMDHMQWLGNTVEEIARTKAGIIKPN 207 Query: 196 KPAIVGEPE----MPSTIADVAQEKGALLQR---------RGVEWNYSVTDHDWAFSDAH 242 I+G + I +VA+ A L R V +V Sbjct: 208 CTVILGPQPHEAKVLPIIKEVAERNHATLLRDSSYGDGELEVVSRTPAVGGQVVTLRTPL 267 Query: 243 GTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 GT E++P+ + A A + + + + + ++ +PGR + V S Sbjct: 268 GTYEDVPVDKFGKHQAHNALAALAAAEVVLPVSGALDGDLVAEALSQVKVPGRIEQVRTS 327 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P +I D HN +AAE L ++ +++ V+ M+ DK + L L+ ++ Sbjct: 328 PTIIIDGGHNVNAAESLRETIEENYHFEQLIGVVAMMADKQVEEYLGVLEPILTKIIVTR 387 Query: 357 -LEGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDT--------VLVC 401 R E+L + D + A A+ +D VL+C Sbjct: 388 NSWRDRVMDPEELEKIAVGVFGEDRVIRVDELPDAIQTAVDLVDEDDELGVGYGHGVLIC 447 Query: 402 GSFHTVAHVMEVI 414 GSF T ++ Sbjct: 448 GSFVTAGDARTML 460 >UniRef50_Q11UV3 Tetrahydrofolylpolyglutamate synthase (Folylpolyglutamate synthetase) n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11UV3_CYTH3 Length = 429 Score = 417 bits (1072), Expect = e-115, Method: Composition-based stats. Identities = 120/429 (27%), Positives = 201/429 (46%), Gaps = 32/429 (7%) Query: 11 SPLASWLSYLENLHSK-------TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTT 63 + +L + GL V ++A A VAGTNGKG++ Sbjct: 1 MDYNQAIQFLYTQYPAFEKQGGLAYKPGLGNVLNISAAFNNPHTAFKSIHVAGTNGKGSS 60 Query: 64 CRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTY 123 L ++L +AGY VG+Y+SPH+ +TER+R+ G +P+ + ++ Sbjct: 61 SSILAAVLQSAGYTVGLYTSPHIHDFTERIRINGVPIPKDIVVDFVQNNTAVFDRFKPSF 120 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T+ A F + Q+D+ I+E G+GGRLDATNIV +V+++T+++LDHT +LG ++ Sbjct: 121 FEITTILAFVWFAKQQVDIAIIETGMGGRLDATNIVQPEVSLITNVSLDHTQFLGNTIQA 180 Query: 184 IGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQR----RGVEWNYSVTDHDWA 237 I EKAGI ++ P ++ + E+ S + A + L + V+ + ++H Sbjct: 181 IASEKAGIIKAGIPVVISELQQELISVYEEQANALNSPLIKAFEAYTVDTIITASEHTEI 240 Query: 238 FSDAHGTLENLPL-----PLVPQPNAATALAA---LRASGLEVSENAIRDGIASAI---- 285 H + + L L N L L+ G + E++I++G+A Sbjct: 241 SITDHVLKKIIALRLDLQGLYQSKNVVGVLTVIDQLKKDGWAIPEDSIKEGLAHVQQLAG 300 Query: 286 LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 GR+QI+S+ P I D AHN +++ K+ + VIGM+ DKDI L+ L Sbjct: 301 FKGRWQIISQKPLTILDAAHNEAGITLSMQQLQLYHKS--IHIVIGMVKDKDIEKVLS-L 357 Query: 346 KSVVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVC 401 V +Y + PR A +L G++ +V A AA +A +D + + Sbjct: 358 LPVQATYYFCQADSPRAMPAAELQTAAAVNGLQGQAITNVNDAVRAARKNAAPDDVIWIG 417 Query: 402 GSFHTVAHV 410 GS + + Sbjct: 418 GSLYVLGEF 426 >UniRef50_Q8D2P3 FolC protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D2P3_WIGBR Length = 428 Score = 416 bits (1070), Expect = e-115, Method: Composition-based stats. Identities = 171/414 (41%), Positives = 255/414 (61%), Gaps = 9/414 (2%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P S + W +Y+ LH K IDL L+RV A RL +LKPAP V GTNGKG+TCR Sbjct: 7 PNTHSSIKDWTNYISKLHYKEIDLRLDRVYYFAKRLNLLKPAPITIVVGGTNGKGSTCRF 66 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 LE + + + KVGVYSSPHL+ Y ER+R+ G E+ + + I S++YFE+ Sbjct: 67 LELMFIYSNIKVGVYSSPHLINYNERIRLHGNEVSDEECINAMNFINKIIKKTSISYFEF 126 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 TL AL +FK +LDVVILEVGLGGRLDATN+VD D++VVT++++DHT++LG + I + Sbjct: 127 STLVALLIFKSKKLDVVILEVGLGGRLDATNVVDIDISVVTNVSIDHTEFLGKNCSEIAK 186 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 EK+GIFR +K +I G ++ ++ V W Y W +S+ + Sbjct: 187 EKSGIFRYKKLSIFGGFNNLLNFKSASEYYKSIPYFLNVHWFYKKNKKYWMWSNKTNNIF 246 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 LP P++ NAATALA +++ + +I G+ +A LPGRFQI+++ P +I DVAHN Sbjct: 247 -LPYPILNIENAATALAVIKSLPFTIPYQSIFKGLKTATLPGRFQIINKKPFIILDVAHN 305 Query: 307 PHAAEYLTGRMKALPKNGRVL-AVIGMLHDKDIAGTLAWLKSVVDDWYCAPL-EGPRGAT 364 P +A++L ++K + KN ++ A+IGML DKDI TL + ++D W CA L E PRGA+ Sbjct: 306 PSSAKHLAKKIKRIKKNFSIIYAIIGMLSDKDIKNTLKYFIKIIDIWNCASLSEFPRGAS 365 Query: 365 AEQL------LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 E++ + N K+F +V A+ + A +D +L+ GSF+T++++++ Sbjct: 366 CEEISIFLNKNKEKNNVKNFKNVISAFKYVINIATKKDCILIFGSFYTISYILK 419 >UniRef50_A3CKF3 Dihydrofolate synthetase, putative n=32 Tax=Streptococcus RepID=A3CKF3_STRSV Length = 464 Score = 416 bits (1070), Expect = e-115, Method: Composition-based stats. Identities = 110/427 (25%), Positives = 192/427 (44%), Gaps = 25/427 (5%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 LS+LE + + + GLER+ + G V +AGTNGKG+T L +L G Sbjct: 9 LSWLEAYRTASPNFGLERMERLLELRGDPHLQLPVIHIAGTNGKGSTIAHLRQLLEVRGL 68 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTYFEYGTL 129 +VG ++SP+LV Y E++ + G + + + + + +T FE T Sbjct: 69 RVGTFTSPYLVSYNEQIAINGNAISDQDLQRLLSLYQDLLAQHATDSGLQGVTEFEIVTA 128 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 A F Q Q+DV I+EVG+GG LD+TN+ + +T++ LDH LG E+I ++KA Sbjct: 129 LAYDYFVQQQVDVAIIEVGMGGLLDSTNVCQPLLTAITTVGLDHVALLGDSLEAIAQQKA 188 Query: 190 GIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQ----RRGVEWNYSVTDHDWAFSDAHG 243 GI + P + G EPE + + A EK + L VE S ++FS+A+ Sbjct: 189 GIIKHGVPIVTGRLEPEALAVVEQKAAEKDSPLFSWSQAYQVEPQESEEGECFSFSNAYR 248 Query: 244 TLENLPLPLVPQPNAATALAALRASGL--------EVSENAIRDGIASAILPGRFQIVSE 295 ++ L+ A A AL L +++ + + +A PGR + +S+ Sbjct: 249 AKDSYQTALMGLHQADNAGLALHLCDLYCQLQSLSLLTKAEVERALLTAEWPGRLERISD 308 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY-C 354 P ++ D AHNPHA L + + + + K + + L+ + Sbjct: 309 QPLILLDGAHNPHALRSLAATLDQHYPTYKKHILFACIQTKALDDMVELLQKIPKAAISL 368 Query: 355 APLEGPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMA-DAKAEDTVLVCGSFHTVAHVME 412 PR + E + G S+ +A + + ++ +L+ GS + +A V + Sbjct: 369 TAFADPRSFSKESMQSLAEQQGLSYKEWPDYVADYLAVEHEPDELLLITGSLYFLAQVRK 428 Query: 413 -VIDARR 418 +++ + Sbjct: 429 SILENCK 435 >UniRef50_UPI0001C36E14 FolC bifunctional protein n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C36E14 Length = 422 Score = 415 bits (1069), Expect = e-114, Method: Composition-based stats. Identities = 114/423 (26%), Positives = 180/423 (42%), Gaps = 21/423 (4%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 YL+ +K LGLERV + +G + V VAGTNGKG+ + S+ Sbjct: 1 MTYNEAKEYLKAASAKGSILGLERVVELLHLMGDPQEKVKVIHVAGTNGKGSFGAMMTSV 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA--RGDISLTYFEYGT 128 L AGYK G +SSP + T+ R+ G E+ T + D T FE Sbjct: 61 LREAGYKTGGFSSPAITDITDSYRINGTEISHEKFTELIGWAAELCEKMDEKPTEFEIMA 120 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGRE 187 +A LF + D+ ++E G+GG DATN+V ++V+T++ DH +LG I Sbjct: 121 AAAYELFYREGCDIAVIECGMGGDTDATNVVNKPVLSVITNVQSDHCKFLGNTIAEIAAH 180 Query: 188 KAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 KAGI + P G + E ++ A+E GA + V+ ++ Sbjct: 181 KAGIIKEGCPVFFGGDDAEAFEVVSAKAREVGAPFRFMDYS---DVSGVRFSLDGMEFDY 237 Query: 246 EN--LPLPLVPQPNAATAL------AALRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 ++ +PL+ AL L G + IR G+A GRF+++ P Sbjct: 238 KDKLYKVPLLGVYQLNNALNVIFCSEILTKKGYNIDYGDIRRGLAKTEWHGRFEMLRREP 297 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 VIFD AHNP + + ++ +V +IG++ DKD L + + Sbjct: 298 YVIFDGAHNPDGIRFASESIERYFGRKKVAMLIGVMADKDYRLYSEMLGNHAAKVFTVKP 357 Query: 358 EGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVC-GSFHTVAHVME 412 + PR + L + +SFD +A +A AK+ + L+ GS + E Sbjct: 358 DNPRALDSASLAKVFSEKNISAESFDVLADGVKSAYEYAKSRNIPLIALGSLYMYREFNE 417 Query: 413 VID 415 V+ Sbjct: 418 VLR 420 >UniRef50_Q47XK6 FolC bifunctional protein n=1 Tax=Colwellia psychrerythraea 34H RepID=Q47XK6_COLP3 Length = 437 Score = 415 bits (1069), Expect = e-114, Method: Composition-based stats. Identities = 175/430 (40%), Positives = 240/430 (55%), Gaps = 19/430 (4%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGT 62 + L WL YLENLHS IDLGL RV VA RL + V TVAGTNGKGT Sbjct: 6 SSHYQD-LTNLDQWLYYLENLHSTEIDLGLSRVGKVAERLAINLNFAKVITVAGTNGKGT 64 Query: 63 TCRTLESILM-----AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG 117 TC +E+ L+ A+ V VYSSPH+ R+ ER+R+ Q++ + A +F IE AR Sbjct: 65 TCAFIENALLNSKELASPRGVAVYSSPHIERFNERLRINKQDVEDQALINAFKRIEVARE 124 Query: 118 DISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWL 177 DISL+Y+EY TL+AL + +A +ILEVGLGGRLDATNI+DAD+AV+T+I LDH +L Sbjct: 125 DISLSYYEYTTLAALLVLMEAMPSFIILEVGLGGRLDATNIIDADIAVITTIDLDHQSFL 184 Query: 178 GPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKG----ALLQRRGVEWNYSVTD 233 G DRESIG EKAGI R E+ ++G+ P ++ + A E + R ++ T Sbjct: 185 GNDRESIGFEKAGIMRQEQDIVIGDTNAPKSVINHANELHKNQVNRIFLRDQDFIVQNTQ 244 Query: 234 HDWAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIV 293 W + L L P +P+ N ATAL L L ++ + + + IA + GR +++ Sbjct: 245 PHWNWKTKQTQLTELKAPHIPRDNVATALMVLEKLNLTLTPDFVNEVIAKTKVAGRTELI 304 Query: 294 SESPR--VIFDVAHNPHAAEYLT---GRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 + VI DV HNP A YL ++K + AV+ ML DKDI+ +L LK Sbjct: 305 KQKGLCDVILDVGHNPQATRYLAGYLKQIKEQANYQNIYAVVAMLGDKDISASLESLKDD 364 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSF 404 +D WY L PR AT E + L + FD+V +A+ A A + D +LV GSF Sbjct: 365 IDFWYTGALSVPRAATKETMASKLALFTNSVNCFDNVDEAFRMANKQANSSDLILVFGSF 424 Query: 405 HTVAHVMEVI 414 TV+ + + Sbjct: 425 FTVSKIRAQL 434 >UniRef50_Q1QDK0 FolC bifunctional protein n=4 Tax=Moraxellaceae RepID=Q1QDK0_PSYCK Length = 457 Score = 415 bits (1068), Expect = e-114, Method: Composition-based stats. Identities = 165/452 (36%), Positives = 247/452 (54%), Gaps = 39/452 (8%) Query: 2 IIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLK---PAPFVFTVAGTN 58 TP + L WL+Y++ +H ID+GL RV VA LGV++ +VFTVAGTN Sbjct: 9 SPSSTPDNQATLTEWLNYMQQIHVSAIDMGLSRVLPVAEALGVVQSAKDDAYVFTVAGTN 68 Query: 59 GKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG- 117 GKG+T + + AAGYK +Y SPHL + ERVR+ G+ + + A+F+++E+AR Sbjct: 69 GKGSTTAVIAQMCQAAGYKTALYQSPHLSVFNERVRIDGEMVSDETLIAAFSKVEAARLQ 128 Query: 118 -DISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDW 176 D++L++FE TL+AL +F +A DV +LEVGLGGRLD NI+D D+AV+T+IA+DH DW Sbjct: 129 CDLTLSFFEMTTLAALLIFAEADCDVWVLEVGLGGRLDVVNIIDPDMAVITNIAIDHVDW 188 Query: 177 LGPDRESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNY-SVTDHD 235 LG + E+IG EKAGI R I G EMP+++ + A + E++Y Sbjct: 189 LGDNVEAIGAEKAGILRDGISVIYGATEMPNSVQQAIDKHQATCYQVSKEFSYCENNSTR 248 Query: 236 WAFSDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRF---QI 292 W +S+A TL+ LP P + N A AL+A+ AS L+V NAI + + L GRF ++ Sbjct: 249 WQYSNAAVTLQ-LPRPALSLTNTANALSAVLASPLDVDTNAIEQALKTVKLAGRFDYREV 307 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRM------------------KALPKNGRVLAVIGMLH 334 +FDVAHN E+L ++ + + + + ML Sbjct: 308 HERH--WLFDVAHNDQGVEFLLAQLVPLWQQHLTQQSTSEQVNQTSGEPATIKMLFSMLG 365 Query: 335 DKDIAGTLAWLKSV---VDDWYCAPLEGPRGATAEQLLEHLG------NGKSFDSVAQAW 385 DKDI + L + + DW+ A ++ PR AT E L L F + +A Sbjct: 366 DKDINKVVQRLTTAGLPISDWFIAEIDYPRAATTEHLQGILASYVDDSQIHEFARLQEAT 425 Query: 386 DAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 A + ++ +D ++VCGSFHT+ + ++ R Sbjct: 426 HAIINASQPQDLIVVCGSFHTIGEALSTLETR 457 >UniRef50_C4Z2M8 Folylpolyglutamate synthase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z2M8_EUBE2 Length = 427 Score = 415 bits (1068), Expect = e-114, Method: Composition-based stats. Identities = 98/428 (22%), Positives = 188/428 (43%), Gaps = 24/428 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + L ++ G++R ++ + + + VAGTNGKG+ C + IL Sbjct: 2 YDEIIDRLNSIGQFASSSGVQRAEILLRDMNNPEEKLNIIHVAGTNGKGSVCAYIAQILQ 61 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 GYK G+++SPHLV ER+R+ + + + ++ +E L YF+Y A+ Sbjct: 62 ENGYKTGLFTSPHLVDVRERIRINNEMISKEDFVEAYEYVEEHHSG-ELAYFDYLFGMAV 120 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 + + + +D V++E GLGGRLDATN V ++V+++I+L+HT LG E I EKAGI Sbjct: 121 YYYNRQNVDYVVMETGLGGRLDATNAVKQPLISVISTISLEHTAILGDTIEKIATEKAGI 180 Query: 192 FRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNY----SVTDHDWAFSDAHGTL 245 + P + + + I ++A + + + + D+ + + Sbjct: 181 IKPGIPVVCSGVDKHAANVIKEIASDNSSACIVLDENSYELKQNTYGNIDFLIHNEYYKN 240 Query: 246 ENLPL---PLVPQPNAATAL---AALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 + L L NA+ AL A L+ SG+++ + ++ ++ GR + V E+ + Sbjct: 241 DCFRLATNALYQIENASIALTVCAVLKDSGVKLDDRLTKEAVSKTHWAGRMEPVKEN--L 298 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRV---LAVIGMLHDKDIAGTLAWL--KSVVDDWYC 354 D AHNP + +L ++ + + ++ DK+ + L Y Sbjct: 299 YVDGAHNPQGIRSFVDSVNSLYESEELSDATLLFSVVSDKNYEQMIKILCECKHFKHIYV 358 Query: 355 APLEGPRGATAEQLLEHLGNGKSFDSVA--QAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 G R ++E + + S S+ + D + + + GS + V V+ Sbjct: 359 TMTGGARRLSSEIIKQTFEVYLSGISIEISDSVDRVIHEWD-NGLMFATGSLYLVGDVVR 417 Query: 413 VIDARRSG 420 ++ + + Sbjct: 418 ALERKENN 425 >UniRef50_B1HVC8 Folylpolyglutamate synthase n=2 Tax=Bacillaceae RepID=B1HVC8_LYSSC Length = 426 Score = 415 bits (1068), Expect = e-114, Method: Composition-based stats. Identities = 107/403 (26%), Positives = 181/403 (44%), Gaps = 22/403 (5%) Query: 35 VSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVR 94 + V A L V VAG+NGKG+T L +L AGY+VG ++SPHL R ER+ Sbjct: 24 MKEVLAHLENPHNKLRVIHVAGSNGKGSTVNALREMLQHAGYQVGAFTSPHLERVNERMT 83 Query: 95 VQGQELPESAHTASFAEIESARGDIS----LTYFEYGTLSALWLFKQAQLDVVILEVGLG 150 + G+ + + F ++ + ++FE TL F +D+ ++E GLG Sbjct: 84 INGEPITDEQFLYYFNKLAKIIEEQYNGDFPSFFEVVTLVMFQFFADQGIDIALIETGLG 143 Query: 151 GRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPST 208 GRLDATN+V +A++T+I+L+HT +LG + EKAGI + P ++G E + Sbjct: 144 GRLDATNVVSPLLAIITTISLEHTAFLGDTFAKVASEKAGIIKKGVPVVIGVSNEEALAV 203 Query: 209 IADVAQEKGALLQRRGVEWNYS-----VTDHDWAFSDAHGTLENLPLPLVPQPNAAT--- 260 I A + A G ++ S + + ++ + ++ L + Sbjct: 204 IKQTADAQQAQCFILGQDFTVSDILQGTDVQQFTYEKSNIVMTDIALKMAGPHQINNAIL 263 Query: 261 ---ALAALRASG-LEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGR 316 A+ ALR G + +S+ +IR G+ A GRF+ + ++ D AHN L Sbjct: 264 AITAILALREEGAITLSDQSIRHGLLYAHWAGRFEQWPQK--IVLDGAHNSEGTAALIQT 321 Query: 317 MKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQL--LEHLGN 374 +K + V L DKD A ++A + V + P A+ L L N Sbjct: 322 LKNVFPKSHYRFVYAALADKDHANSIALMDDVATSITFTQINLPNAMPAKDLSILSTNAN 381 Query: 375 GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 + ++ + + ED V++ GS + +A+V + + Sbjct: 382 KSYHEDWMESVQTVLRERAEEDVVVITGSLYFIANVRQWLQEE 424 >UniRef50_A8RV28 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RV28_9CLOT Length = 454 Score = 415 bits (1067), Expect = e-114, Method: Composition-based stats. Identities = 116/455 (25%), Positives = 177/455 (38%), Gaps = 54/455 (11%) Query: 15 SWLSYLENLH-SKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 YL+ + LE V LG VAGTNGKG+ C L SIL Sbjct: 3 QAEEYLDRIPMWTRKKNSLEDVRRFLDYLGNPDRDRPAIHVAGTNGKGSVCAFLTSILGE 62 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYG 127 AGY G + SPHLV ER + G+ + + + +F + A + T+FE+ Sbjct: 63 AGYSTGTFISPHLVEVRERFLINGEMVDQESFEGAFETVLEASRKLADQGLCHPTFFEFL 122 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGR 186 A+ LF+ +DV+ILE G+GGRLD TN+++ V+TSI++DHT +LG I Sbjct: 123 FYMAMVLFRMHDVDVMILETGMGGRLDTTNVLERPAACVITSISMDHTRYLGDTLAKIAG 182 Query: 187 EKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVT----DHDWAFSD 240 EKAGI ++ P + G+PE+ + + A KGA G + Y Sbjct: 183 EKAGIIKTGVPLVFDDGQPEVSTILEGFAFRKGAARYPVGRDDFYVEEIGEKGLSINARM 242 Query: 241 AHGTLENLPLP---LVPQPNAATALAALRASGLE-------------------------V 272 G L +P NA A+ L + Sbjct: 243 KDGRCLELEIPFEAFYQAENAMLAVRTLDVLRYPGECPRTGCRMPGHGPCICPDGKEWGI 302 Query: 273 SENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALP--KNGRVLAVI 330 S+ I G+ + PGR + V P + D AHNP E + + + + Sbjct: 303 SDQHIIKGLKNTFWPGRMEQVR--PGIYLDGAHNPGGIEAFIQTAGEISDRQGKKPWLLF 360 Query: 331 GMLHDKDIAGTLAWLKSVV--DDWYCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQ 383 + DKD L + + + RG AE+L S+ Sbjct: 361 AAVSDKDYERMAEQLCKEMIWEAVGVVHMNSDRGLAAEELARVFRTYTSRPVYSYGDTKS 420 Query: 384 AWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 A + MA+ E + GS + + + V++ + Sbjct: 421 AVED-MAEKSREGLLFCAGSLYLIGEIKAVLEQKP 454 >UniRef50_C8WXM1 FolC bifunctional protein n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXM1_ALIAD Length = 432 Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats. Identities = 115/424 (27%), Positives = 175/424 (41%), Gaps = 25/424 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + Y+ L + GL+R+ + ++L + + VAGTNGKG+ C L ++L Sbjct: 3 YEEAVRYISTLRRFGMKPGLDRMRRILSKLDHPESDLCFYHVAGTNGKGSVCAMLAAMLT 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-DISLTYFEYGTLSA 131 A GY+ G+Y+SP L + RV + G + E + A T FE T A Sbjct: 63 ALGYRTGLYTSPGLGGFNGRVAIDGAPISEPEFAEHVEAVRRASDTSDPPTEFEVLTAVA 122 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 L F+ A ++ V+ E GLGGRLDATN+V V +T+++ DH + LGP I REKAGI Sbjct: 123 LLAFRSAGVERVVWETGLGGRLDATNVVWPHVTAITNVSYDHVEILGPTLVDIAREKAGI 182 Query: 192 FRSEKPAIVGEPE-MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN--- 247 + P + + I A +G+ L G + +++T A+ L Sbjct: 183 VKPGVPVVTACADGAYRVIERTAARRGSRLVSVGRDVQFTITGAGVRLRGAYRGLFRDAP 242 Query: 248 -LPLPLVPQPNAATA---LAALRASGLEVSENAIRDGIAS---AILPGRFQIVSESPR-V 299 + L L + A A LA L ++E +AS P R ++ R V Sbjct: 243 SVRLGLCGEHQAQNAAVSLAMLELGEGRIAEANWERALASLERVRWPLRCEVFDVGGRLV 302 Query: 300 IFDVAHNPHAAEYLTGRMKALPKN---GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 + D AHN A L ++ L K V DKD+ G LA + + D Sbjct: 303 VIDGAHNEEGARTLARALRRLGKGVGANGWRMVFAAFADKDVRGMLAQMLPLACDALMVR 362 Query: 357 LEGPRGATAEQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 PRGA L S+ A A+ + ++V G+ + Sbjct: 363 SPHPRGADPRALAALACEIRPDLSIHVMSSIEDAVQEALDHPEP---IVVWGNLYMAELA 419 Query: 411 MEVI 414 I Sbjct: 420 RNTI 423 >UniRef50_B0TC04 Folylpolyglutamate synthase n=5 Tax=Clostridia RepID=B0TC04_HELMI Length = 459 Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats. Identities = 118/449 (26%), Positives = 193/449 (42%), Gaps = 44/449 (9%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF--VFTVAGTNGKGTTCRTLES 69 L+YL++L + GL R++ + RLG + GTNGKG+T + Sbjct: 9 SYDDALAYLKDLTKFGFNFGLGRITELLRRLGEPHRKKRPAFIHIGGTNGKGSTSVMTAA 68 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTY 123 +L AAG++VG+++SPHL YTER R+ G+ +P+ A AE+ + T Sbjct: 69 VLQAAGHRVGLFTSPHLHCYTERTRINGKPIPKETMAALIAELRPHLEAMVAGGFEHPTE 128 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE T +L F + +DVV+LEVGLGG +D+TN+V VA +T+++ DH D+LG Sbjct: 129 FEVWTALSLLYFAREAVDVVVLEVGLGGSIDSTNVVTPIVACITNVSFDHMDYLGTTLPE 188 Query: 184 IGREKAGIFRSEKPAIVGEPEM--PSTIADVAQEKGALLQRRGVE------------WNY 229 I KAGI ++ P + + + + + AQ GA + + + + Sbjct: 189 IAAVKAGIVKAGVPLVTASDDAAVLAVLREKAQRLGAPIIQVLRQGPRLPSATPVRWYPV 248 Query: 230 SVTDHDWAFSDAHGTLENLPLPL---VPQPNAATALAALRAS---GLEVSENAIRDGIAS 283 + G L PL Q N ATA+A L A+ G + + + G+ Sbjct: 249 TARRAGILVEGRFGIYGPLTPPLSGRHQQANLATAVAVLEAAKEKGFDWRADHLEAGLGQ 308 Query: 284 AILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLA 343 PGR + + + D AHN A L ++ G+ + V+GML DK+ + Sbjct: 309 VSWPGRLERI---GPFLLDGAHNVAGALSLAAALRE-EGAGKYVFVLGMLADKERERVVD 364 Query: 344 WLKSVVDDWYCAPLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAED--- 396 L + PR + L + +A + A A+ + Sbjct: 365 ILAPLAKAIIVTRPNSPRAGEWQALASLAARRCDSVTVVSDIGEALEMARLSAQDPEKAD 424 Query: 397 -----TVLVCGSFHTVAHVMEVIDARRSG 420 ++V GS + VA +I + + Sbjct: 425 GEGHAPIVVTGSLYMVAEARGIILSCEND 453 >UniRef50_D1AAV2 FolC bifunctional protein n=1 Tax=Thermomonospora curvata DSM 43183 RepID=D1AAV2_THECD Length = 471 Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats. Identities = 128/465 (27%), Positives = 194/465 (41%), Gaps = 55/465 (11%) Query: 9 AASPLASWLSYLENLHSK-TIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 S ++ + + D L+R++ + LG + A V V GTNGK +T R + Sbjct: 5 HLDDYRSTVAAIMARGVEWKFDPTLDRIADLMDLLGRPQDAYPVIHVTGTNGKSSTARMI 64 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISL 121 E++L G + G+ +SPHL ER+ V G+ + E A A++ ++ A+ + L Sbjct: 65 ETLLRERGLRTGLSTSPHLTTMRERIVVDGEPISEEAFVAAYRDVAPYLEMVDAKHERPL 124 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 +YFE T A +F A +DV ++EVG+GG DATN+ D V+VVT I+LDH LGP Sbjct: 125 SYFETLTAMAYAVFADAPVDVAVIEVGMGGVWDATNVADGTVSVVTPISLDHLRHLGPTI 184 Query: 182 ESIGREKAGIFRSEKPAIVGEPEMP--STIADVAQEKGALLQRRGVEW-----NYSVTDH 234 E I EKAGI + A++ + ++P + E GA R G+E+ + +V Sbjct: 185 EDIAAEKAGIIKPGAIAVLAQQQLPVAQVLLRRVVEVGATAAREGMEFGVLGRDLAVGGQ 244 Query: 235 DWAFSDAHGTLENLPLPLVPQPN---------------------------AATALAALRA 267 HG E + LPL AAT +AA Sbjct: 245 QLRLQGLHGVYEEIFLPLFGSHQAGNAACALAAVEAFASGAPSRTGGDLSAATRIAAGED 304 Query: 268 SGLE---VSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNG 324 + + +R A PGR +I P V+ D AHNP + Sbjct: 305 FEGDHGQLDPALVRSAFAKVTSPGRLEIARTGPTVLIDSAHNPAGMSATVNAITEDFGFT 364 Query: 325 RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEH------LGNGKSF 378 R++ V+ DKD+AG L L+ V+ + R QL E Sbjct: 365 RLIGVVAAAGDKDVAGMLEQLEPVLTELIVTRNTSHRSMPPRQLGELAEGIFGAERVHVI 424 Query: 379 DSVAQAWDAAMADAKAEDT-----VLVCGSFHTVAHVMEVIDARR 418 D + A D A+A A+ VL+ GS T ++ Sbjct: 425 DRLDDAIDRAVALAEETGEYQGAGVLITGSVVTAGEARTLLRVEE 469 >UniRef50_B3DQR8 Folylpolyglutamate synthase n=18 Tax=Bifidobacterium RepID=B3DQR8_BIFLD Length = 543 Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats. Identities = 119/431 (27%), Positives = 198/431 (45%), Gaps = 40/431 (9%) Query: 30 LGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRY 89 L L+R++L+ LG + + V + GTNGKG+T R E+I A G + G+Y+SPHL + Sbjct: 32 LDLDRMNLMLDILGHPEQSFRVIHITGTNGKGSTARMAEAICRAYGMRTGLYTSPHLEKI 91 Query: 90 TERVRVQGQELPESAHTASFAEIESAR----------GDISLTYFEYGTLSALWLFKQAQ 139 ER+ + GQ+L + + + + G +++FE T A+W F Sbjct: 92 NERIAIDGQQLSDDDFIDIWDQTKDLVALVDAKMEEQGKPKMSFFEVLTAMAIWKFADTP 151 Query: 140 LDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAI 199 +DV I+EVG+GG DATN+++AD A++ + +DH WLG E I EKAGI + AI Sbjct: 152 VDVAIVEVGMGGLWDATNVLNADAAIIGPVDMDHMQWLGDTVEQIATEKAGIIKPNCTAI 211 Query: 200 VGEPE----MPSTIADVAQEKGALLQRRGVEWNYS-----VTDHDWAFSDAHGTLENLPL 250 +G + +A+ A+ A+L R G E S V + +GT E +P+ Sbjct: 212 IGPQPHEEAVMPILAEAAERNHAMLVRDGYEMTVSDRMAAVGGQVATLTTPNGTYEGVPI 271 Query: 251 PLVPQPNAATAL------AALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 + A AL + + + + + ++S +PGR + + SP +I D Sbjct: 272 AKFGEHQAHNALAALAASEVVIPVNGPLDGDLVGEALSSVKIPGRIEQIRTSPTIILDGG 331 Query: 305 HNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP-LEGPRGA 363 HN +AAE L ++ +++ V+ M+ DK + L L+ ++ R Sbjct: 332 HNVNAAEALRKAIEESYDFKQLVGVVAMMRDKQVEEYLGVLEPILSSVVVTENSWRERVM 391 Query: 364 TAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAEDT--------VLVCGSFHTVAH 409 A++L + ++ A A+ AED VL+CGSF T Sbjct: 392 PADELEKIAVDVFGRDRVIKEANLPDAIQTAVNMVDAEDELGVGYGHGVLICGSFVTAGD 451 Query: 410 VMEVIDARRSG 420 +++ S Sbjct: 452 ARLMLEEHASP 462 >UniRef50_B4RUR1 Bifunctional folylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Alteromonas macleodii RepID=B4RUR1_ALTMD Length = 443 Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats. Identities = 183/421 (43%), Positives = 250/421 (59%), Gaps = 15/421 (3%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 + L WLSYLE++H ID+GL+RV VA + + V TVAGTNGKGTTCR Sbjct: 21 SSNTQKSLGQWLSYLESIHPSAIDMGLDRVKAVAQSMALSLSQSLVITVAGTNGKGTTCR 80 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD-----IS 120 LE +++ G V VYSSPHL Y ERVR G+ P + +F +E +R + I+ Sbjct: 81 LLEQAMLSQGKSVAVYSSPHLTDYRERVRYNGELPPANEFVKAFEFVEKSRKETEGDPIT 140 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 LTYFE+GTL+A+ + + ++DVVILEVGLGGRLDATNI+ D+A++T+I LDH DWLG Sbjct: 141 LTYFEFGTLAAMKMMQSWEVDVVILEVGLGGRLDATNIIHPDLAIITTIDLDHQDWLGNT 200 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDH--DWAF 238 RE I REKAGI R A+VG+ PS++ DV E A ++ ++ V +W++ Sbjct: 201 REKIAREKAGIMRKNGNAVVGDLFPPSSLYDVVNELQANVRWATQDFVTVVASDYSEWSW 260 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 + + +LP P +P NA+TALAAL L E +RD I + +PGR + +SESP Sbjct: 261 KGKNSSYASLPYPKIPLQNASTALAALELLELLPEEQVVRDIIKNTTMPGRQETISESPL 320 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 V+ DVAHNP A + + ++ V+GML DK IA TLA L ++ DWY A Sbjct: 321 VVVDVAHNPQATAEMQNWLNRYDV-SKMRIVVGMLKDKSIAETLAPLAALNADWYVASTS 379 Query: 359 GPRGATAEQLLEHL-------GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 GPRG AE L L N ++F +V A+ A+AD + + +LV GSF TVA V+ Sbjct: 380 GPRGCEAEVLENALVNAGTTIENIETFQTVTSAYQRALADYQTGELILVFGSFVTVADVL 439 Query: 412 E 412 Sbjct: 440 A 440 >UniRef50_A9BIJ6 FolC bifunctional protein n=1 Tax=Petrotoga mobilis SJ95 RepID=A9BIJ6_PETMO Length = 438 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 122/433 (28%), Positives = 207/433 (47%), Gaps = 31/433 (7%) Query: 11 SPLASWLSYLENLHS--KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 LA+ + YL + + LGLER+ ++ R+G + + GTNGKG+ + Sbjct: 1 MELANLVDYLYQRGAANFKVKLGLERIDELSKRIGSPQNTFKSIHITGTNGKGSVTTAIS 60 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAE-------IESARGDISL 121 IL G KVG Y SPHLV TER++V G+ + E + E ++ + + Sbjct: 61 RILRFNGMKVGTYISPHLVSITERIKVNGENISEKEFVEIYNEIEEEIKTMDLKGEEYAP 120 Query: 122 TYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDR 181 ++FE T A F++ ++DV + EVGLGGRLDATNI+++DV+V+TSI+ DH LG Sbjct: 121 SFFEITTAMAFKYFEKQKVDVGVFEVGLGGRLDATNIINSDVSVITSISKDHIKTLGDTL 180 Query: 182 ESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGA-LLQRRGVEW-----NYSVTD 233 E+I EKAGI + I+G + I + A+E A + G ++ Y + + Sbjct: 181 EAIAYEKAGIIKKNNFLILGNIDESPKKVILNKAKEVNAEKIYEHGKDFYSINHRYFINN 240 Query: 234 HDWAFSDAHGTLENLPLPL---VPQPNAATALAA----LRASGLEVSENAIRDGIASAIL 286 + + + +++L N T+LAA ++ G +S +R+ +A+ Sbjct: 241 NMLDYHGLNYEIKDLIFGANGTFQIENVTTSLAATEAFMQKFGKTLSIEKVREAMANFYW 300 Query: 287 PGRFQIVSESP-RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 GRF+ + +++FD AHN AA+ L + + +A+IG+L DKD Sbjct: 301 EGRFEYTEINGKKMVFDGAHNLAAAQQLEKSVNLYFPTQKKIALIGILDDKDYEKMSQIF 360 Query: 346 KSVVDDWYCAPLEGPRGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVC 401 SV D + RG E + E N + ++ ++ + ++ D V Sbjct: 361 ASVFDKIIVTSVPSERGRHPELIYEEFKKHTKNVEFIKDPSEGFNKLL--SEKSDIYFVT 418 Query: 402 GSFHTVAHVMEVI 414 GS + + + E++ Sbjct: 419 GSLYLLGKMKELM 431 >UniRef50_A5KJF0 Putative uncharacterized protein n=4 Tax=Clostridiales RepID=A5KJF0_9FIRM Length = 445 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 108/428 (25%), Positives = 181/428 (42%), Gaps = 21/428 (4%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 YL+ L LGL+ + + LG + +AGTNGKG+ +IL Sbjct: 12 TYKEARVYLDELSKYGSVLGLDAIRGLLRELGNPQDDLRFIHIAGTNGKGSVLAYTSTIL 71 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR------GDISLTYFE 125 AGY++G Y SP +V Y ER++V G+ + + A +++ A G T FE Sbjct: 72 SEAGYRIGRYVSPTVVSYRERIQVDGEMISKHAFAEETEKVQDAIVRLKEAGKQLPTVFE 131 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVA-VVTSIALDHTDWLGPDRESI 184 T A +K+ + D V+LE GLGG DATN+V V V + I++DH +G I Sbjct: 132 AETAIAFLYYKRMKCDFVVLESGLGGMEDATNVVKNTVCAVFSPISMDHIGVIGNTLSEI 191 Query: 185 GREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 KAGI + + E+ + A++ G + E + + ++ Sbjct: 192 AENKAGIIKPGCIVVSAPQKQEVREILEQKARQFGCPIIYAEPEKAVVLEEDYRGMRFSY 251 Query: 243 GTLENLPLPLVPQPNAATALAALRASGLE-----VSENAIRDGIASAILPGRFQIVSESP 297 EN+ + L + A+ A A + + A+ G GRF +SE P Sbjct: 252 KDSENISIRLSGKYQLINAVTAWEAVHVPGLLKKEEKRAVETGFFDTEWFGRFTCISEWP 311 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 + D AHN AA+ L ++A +++ ++G+ DK+ + Y L Sbjct: 312 VFLVDGAHNEDAAKRLRESIEAYFPGRKLIYIMGVFQDKEYEKIIRLTIPYAKCVYTVDL 371 Query: 358 EG-PRGATAEQLLEHLGN------GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 R +A++L E + + + QA A+ +A +D +L GS + V Sbjct: 372 PNKERTLSAQKLKEAVEAQSEYVPAYAVGEIKQAVKEALENADEDDVILAFGSLSYLGKV 431 Query: 411 MEVIDARR 418 E ++ + Sbjct: 432 KEAVEKEQ 439 >UniRef50_A5TUM3 Tetrahydrofolate synthase n=15 Tax=Fusobacterium RepID=A5TUM3_FUSNP Length = 415 Score = 412 bits (1061), Expect = e-114, Method: Composition-based stats. Identities = 117/419 (27%), Positives = 203/419 (48%), Gaps = 15/419 (3%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + + L L +I LGL+ + + LG + + V + GTNGKG+ T+ Sbjct: 2 EEKMNINDLLEELYAYSMFSIRLGLDNIKEICKYLGNPEKSYKVIHITGTNGKGSVSTTV 61 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD--ISLTYFE 125 E IL+ AGYKVG Y+SPH++++ ER+ + + + + ++ + I T+FE Sbjct: 62 ERILLDAGYKVGKYTSPHILKFNERIIFNDKYISDENVAKYYERVKKIIDEHNIQATFFE 121 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T FK + D VILE G+GGR DATN+ D V+V+T+++L+HT++LG I Sbjct: 122 VTTAMMFDYFKDMKADYVILEAGMGGRYDATNVCDNIVSVITNVSLEHTEYLGDTIYKIA 181 Query: 186 REKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWA--FSDA 241 +EKAGI ++ I + P++ I + A +K + + + YS+ + + Sbjct: 182 KEKAGIIKNCPYTIFADNNPDVKKAIEE-ATDKYVNVLEKYRDSTYSLDFNTFTTNILIN 240 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 E N A ++ G + EN I++ + I RF++ S++P VIF Sbjct: 241 GNKYEYSLFGDYQYKNFLCAYEVVKYLG--IDENIIKEAVKKVIWQCRFEVYSKNPLVIF 298 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP-LEGP 360 D AHN E L +K V ++ +L DKD L + + + P Sbjct: 299 DGAHNLAGVEELIKIVKQHFSKDEVTILVSILKDKDRVSMFRKLNEISSNIVLTSIPDNP 358 Query: 361 RGATAEQLLEHLGNGKSF---DSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 R +TA++L +++ N K F + +A++ A+ +K + CGSF+ + + E ++ Sbjct: 359 RASTAKELYDYVENKKDFEYEEDPIKAYNLAL--SKKRKLTICCGSFYILIKLKEGLNG 415 >UniRef50_D0WR93 Tetrahydrofolate synthase n=2 Tax=Actinomycetales RepID=D0WR93_9ACTO Length = 571 Score = 412 bits (1060), Expect = e-113, Method: Composition-based stats. Identities = 127/437 (29%), Positives = 195/437 (44%), Gaps = 36/437 (8%) Query: 20 LENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVG 79 L + LERV A LG + A + GTNGK +T R +E++L G + G Sbjct: 135 LTRAPEHKVQPSLERVRKALAMLGNPERAFRSIHITGTNGKTSTARMIEALLRERGLRTG 194 Query: 80 VYSSPHLVRYTERVRVQGQELPESAHTASFAEIES----------ARGDISLTYFEYGTL 129 ++SPHL ER+ + G + A + E+ A G +++FE T+ Sbjct: 195 RFTSPHLTSVRERMAIDGAAISREDFLAVWEEVNPVVELVDRESTAAGGPRMSFFEVFTV 254 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 A F A +DV ++EVG+GG DATN+++ADVAV+ +A+DH WLG E I REK Sbjct: 255 MAYAAFANAPVDVAVVEVGMGGLWDATNVIEADVAVILPVAMDHERWLGHTIEEIAREKV 314 Query: 190 GIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNY-----SVTDHDWAFSDAH 242 GI + + E E + + D +E A L G + +V Sbjct: 315 GIVKPGSFVVSAEQEDSVAQIVMDATREAKARLVAEGPSLHLVSRETAVGGQLVTLQTPA 374 Query: 243 GTLENLPLPLVPQPN-----AATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 E++PL L + A A A G + + + S PGR +IV SP Sbjct: 375 ARYEDVPLALKGEHQARNAAIALAAAEAFFGGGAFAADVVEHAFMSVSSPGRLEIVRSSP 434 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 V+ D AHNPH A+ ++ R++ V+GM+ DKD+ G L L+ V+D + Sbjct: 435 TVVVDAAHNPHGAQATADALREYFPG-RLVGVVGMMADKDVEGFLGVLEPVLDAVVVTDI 493 Query: 358 EGPRGATAEQLLEHL------GNGKSFDSVAQAWDAAMADAKAED-------TVLVCGSF 404 R A++L + G ++A+A D A A+++D V+V GS Sbjct: 494 ASDRAMDADELADIAGGVFGDGRVFVERNLAEAIDRAAGLAESDDGAPMASPAVVVLGSI 553 Query: 405 HTVAHVMEVIDARRSGG 421 VA ++ + G Sbjct: 554 QLVAAARTLMGKPGADG 570 >UniRef50_Q13EP9 FolC bifunctional protein n=37 Tax=Alphaproteobacteria RepID=Q13EP9_RHOPS Length = 448 Score = 412 bits (1060), Expect = e-113, Method: Composition-based stats. Identities = 136/442 (30%), Positives = 194/442 (43%), Gaps = 29/442 (6%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNG 59 M PQ ++ + + L LH IDL L R+ + A L + V +AGTNG Sbjct: 1 MSAATAPQPSALVGELRARLAQLHPAQIDLTLGRIERLLAALDHPQRRLPPVIHIAGTNG 60 Query: 60 KGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRV----QGQELPESAHTASFAEIESA 115 KG+T L +IL AAG V Y+SPHLVR E VR+ G + + A+ A E Sbjct: 61 KGSTLAFLRAILEAAGLSVHAYTSPHLVRVNETVRLGRPGGGALVSDDEFAAALAHCERV 120 Query: 116 RGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHT 174 +T FE T +ALWLF Q DV +LEVGLGGRLDATN++D V+T I +DHT Sbjct: 121 NQGAPITLFEIETAAALWLFAQHPADVTLLEVGLGGRLDATNVIDQPLACVLTPIGIDHT 180 Query: 175 DWLGPDRESIGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVT 232 ++LGP I EKAGI R P IV + I A+ A L RG +W+ V Sbjct: 181 EFLGPTLADIAAEKAGIIRRGVPVIVAGQQNDAMDVIEREAERLRAPLHARGQQWHVEVE 240 Query: 233 DHDWAFSDAHGTLENLPLPLVPQP---NAATALAALRA-SGLEVSENAIRDGIASAILPG 288 A+ D G ++ L + NA A+A LRA + A + G+ SA P Sbjct: 241 HGRLAYQDDRGLMDLTAPKLFGRHQIDNAWLAIATLRAQQRFTFDQAAYQAGLLSADWPA 300 Query: 289 RFQIVSESPRV---------IFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKD 337 R Q ++ + D HN + L + + ++ + GM+ +KD Sbjct: 301 RMQRLTTGRLIDEAPPGSELWLDGGHNADGGRVAAAALGDLEERVSRPLVIIAGMMANKD 360 Query: 338 IAGTLAWLKSVVDDWYCAPLEG-PRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADA 392 + L + P+ E+L + + DSV A A Sbjct: 361 ASAFLTNFTGLTRHVIAVPIPDRDGAMPPEKLADAGRALGLRVELADSVEAALSRIAGLA 420 Query: 393 KA-EDTVLVCGSFHTVAHVMEV 413 +L+ GS + HV+ + Sbjct: 421 YELPPRILITGSLYLAGHVLRL 442 >UniRef50_A7NFK2 FolC bifunctional protein n=2 Tax=Roseiflexus RepID=A7NFK2_ROSCS Length = 454 Score = 412 bits (1060), Expect = e-113, Method: Composition-based stats. Identities = 126/446 (28%), Positives = 179/446 (40%), Gaps = 36/446 (8%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 QA L S++ + L R + A LG + A VAGT GKG+T Sbjct: 2 DYQQALDYLYSFIGGQQGAQRPPPMFNLVRTRALLAALGNPQHAMPSVIVAGTKGKGSTA 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI----- 119 LE+I AAG + G+++SPHL Y ER++V Q + + I + Sbjct: 62 AFLEAIARAAGLRTGLWTSPHLHTYRERIQVNRQPITRDELVQAVESIRPIVESMANGPI 121 Query: 120 -SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLG 178 + F G AL F + +D+ ILEVG+GGR D+ +V ++VVT I+ DH D LG Sbjct: 122 GAPVTFAIGFGLALRYFAERNVDLAILEVGVGGRFDSAAVVTPILSVVTPISYDHMDLLG 181 Query: 179 PDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYS------ 230 I EKAGI + PAI PE + A E GA L S Sbjct: 182 DTLAQIAWEKAGIMKPGTPAISAPQHPEALGALIRCAAEIGAPLYVVQDAAPESAVVCEP 241 Query: 231 --------VTDHDWAFSDAHGTLENLPLPLVPQPNAATALAA------LRASGLEVSENA 276 + ++ L A A LR +GL +++ A Sbjct: 242 FLPGPWRIPAERYLEVEPQQRFQRDIMPSLPGIFQVVNARLATGAALLLRDAGLPITDAA 301 Query: 277 IRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDK 336 I G+ASA PGR +I+ SP ++ D AHN + + L + + R + V G DK Sbjct: 302 IAAGLASARWPGRMEIIDGSPPIVLDGAHNGESIQQLVVSLNRIFPGRRCVIVFGASRDK 361 Query: 337 DIAGTLAWLKSVVDDWYCAPLEGPRGATA-EQLLEHLGNGKSFD-------SVAQAWDAA 388 D+A + L +D PR A +L + D A+A A Sbjct: 362 DLARMIPALAPAIDALVLTASRHPRALVALHELRQQFAPLVRSDTPIDIVIDPAEALARA 421 Query: 389 MADAKAEDTVLVCGSFHTVAHVMEVI 414 A D + V GS VA E + Sbjct: 422 QDLAAPNDLICVTGSLFVVAAAREAL 447 >UniRef50_B1VGM7 Dihydrofolate synthase / folylpolyglutamate synthase n=28 Tax=Actinomycetales RepID=B1VGM7_CORU7 Length = 545 Score = 412 bits (1060), Expect = e-113, Method: Composition-based stats. Identities = 135/464 (29%), Positives = 208/464 (44%), Gaps = 50/464 (10%) Query: 6 TPQAASPLASWLSYLENLHS-KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 T + + LA+ + L ID LER+ ++ LG + + VAGTNGK + Sbjct: 82 TEEDLADLAAVEAELNQRWPETKIDPSLERIEMLMDLLGNPERSFATIQVAGTNGKTSVV 141 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES---------- 114 R +ES+L A + G +SPHL TER+ V G+ + + + EI+ Sbjct: 142 RMIESLLRAFHRRTGRTTSPHLQLVTERIAVDGEPIHPQDYIRMWREIQPMVEMVDAKST 201 Query: 115 ARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHT 174 A G ++ FE A F A +DV ++E G+GG DATN+V++DV+V+T I +DHT Sbjct: 202 AEGGPQMSKFEVLVALAYSAFADAPVDVAVIETGMGGTWDATNVVNSDVSVITPIGMDHT 261 Query: 175 DWLGPDRESIGREKAGIFR-----------SEKPAIVG--EPEMPSTIADVAQEKGALLQ 221 D+LG I EKAGI + E AI+ EPE + + A E A + Sbjct: 262 DFLGDTLTEIAGEKAGIIKSRWDREDLLTPPENIAIISEQEPEAMRVLLERAVEVDAAVA 321 Query: 222 RRGVEW-----NYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS-------- 268 R G E+ +V GT +++ LPL + A A AL A Sbjct: 322 RAGAEFGAVESTVAVGGQRLTIKGLAGTYDDIFLPLSGEHQARNAATALAAVEAFFGAGG 381 Query: 269 GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLA 328 ++ + +R+G A+ PGR + V +P V D +HNPH A L + R++ Sbjct: 382 DRQLDVDKVREGFATVTSPGRLERVRATPSVFIDASHNPHGAAALAKAVDRDFDFRRLIG 441 Query: 329 VIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN------GKSFDSVA 382 V+ +L DKD G LA L+ V+DD ++ PR + L E+ + + + Sbjct: 442 VVAVLGDKDARGILAALEPVLDDVVITEVQSPRALPVDVLAEYARDAFGEERVHVAEQLP 501 Query: 383 QAWDAAMADAKAEDT-------VLVCGSFHTVAHVMEVIDARRS 419 A + A+ A+ + VLV GS T + + Sbjct: 502 TAVETAIQLAEDDSDGMLAGAGVLVTGSVVTAGEARTLFAKKPE 545 >UniRef50_A6BCX0 Putative uncharacterized protein n=9 Tax=Clostridiales RepID=A6BCX0_9FIRM Length = 446 Score = 412 bits (1059), Expect = e-113, Method: Composition-based stats. Identities = 116/441 (26%), Positives = 186/441 (42%), Gaps = 30/441 (6%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M+ K+ P+ +Y+E + T LE RLG + VAGTNGK Sbjct: 2 MLTKKEPETF-TYEEAAAYIEEIPKFTKKHTLEHTKTFLKRLGNPAADRKIVHVAGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI- 119 G+ C L++ILMA G + G ++SPHLV ER+RV ++ F ++ + Sbjct: 61 GSVCAYLQAILMAEGKRTGFFTSPHLVSVNERIRVDNIQIDNETFLKVFRKVLKIVRQMV 120 Query: 120 -----SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDH 173 +YFE+ + F + ++ +ILE GLGGRLDATN +D +A++TSI+LDH Sbjct: 121 EDGIEHPSYFEFLFGMGMTAFAETDVEYIILETGLGGRLDATNAIDNPALAIITSISLDH 180 Query: 174 TDWLGPDRESIGREKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVE-WNYS 230 T LG E I EKAGI + P + I A E G + + Sbjct: 181 TAILGDTIEKIAGEKAGIIKPGVPVFFDGSSKKAAEVIKAKASELGVSCREVTKNAYEIQ 240 Query: 231 VTDHDWAFSDAHGTLEN---LPLPLVPQPNAATALAALRA-----SGLEVSENAIRDGIA 282 + + +P+ A A AL A +G E+ + ++ +A Sbjct: 241 EVHRKYIAFSRRSAYDKDVIFQVPMCGCYQAMNAELALEASEYLLAGEEIHMDRWKEALA 300 Query: 283 SAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGR--VLAVIGMLHDKDIAG 340 GR + V + D AHNP A E +KAL ++ R ++ + + DK Sbjct: 301 ELHWEGRMERVGAH--ITVDGAHNPGAMEAFVESVKALDESERGEMVLLFSAVSDKKYDQ 358 Query: 341 TLAWLKSVVD--DWYCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADAK 393 + +L +D + +E RG AE+L + + + A AM + Sbjct: 359 MIEYLCENLDVKAYVVTQIEDERGVPAEELADVFRRYTDRPVYCKERLEDAVRTAMNERG 418 Query: 394 AEDTVLVCGSFHTVAHVMEVI 414 + GS + V + +++ Sbjct: 419 ETGEIYCLGSLYLVGMMKKLL 439 >UniRef50_C9M7C2 Tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=Synergistaceae RepID=C9M7C2_9BACT Length = 439 Score = 411 bits (1058), Expect = e-113, Method: Composition-based stats. Identities = 138/433 (31%), Positives = 202/433 (46%), Gaps = 26/433 (6%) Query: 6 TPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCR 65 P + L ++ S GLERVS++ LG + A +AGTNGKG+T Sbjct: 2 RPSDIALYEKVEKALSDVSSDGWHPGLERVSVLLEALGTPQ-AFPAIHLAGTNGKGSTAA 60 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS----- 120 LESI AAGYK +Y+SPHL+ ER+ V G LP + ++ Sbjct: 61 FLESIYRAAGYKTALYTSPHLIHLGERLLVNGYPLPPELWAEASQKVAQTILGHPWLSQH 120 Query: 121 -LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLG 178 TYFE T +A L + A+ DV I+E G+GGRLDATNI+ D +AV+T I DH +LG Sbjct: 121 RPTYFETLTAAAYLLVRDAKPDVAIIETGMGGRLDATNILPDCRLAVITPIDWDHMAFLG 180 Query: 179 PDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGV----EWNYSVT 232 +I EK GI +PAI + PE+ K + + S+ Sbjct: 181 NTLSAIASEKFGIIVPGRPAIFSDNHPELAPEFRACCAAKNSPAYTMDECRIFDAETSLD 240 Query: 233 DHDWAFSDAHGTLENL--PLPLVPQPNAATALAA--LRASGLEVSENAIRDGIASAILPG 288 +++ + GT L NA+ AL A + V+E A R+G+ + PG Sbjct: 241 GCEFSLTTPCGTNRWFSRLLGTYQPENASLALRATEILQKDFPVTEEARREGLRTVRWPG 300 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGR-VLAVIGMLHDKDIAGTLAWLKS 347 R ++VS P VI D AHNPH + LT + AL R + V + DKD AG +++ S Sbjct: 301 RLEVVSRDPDVILDGAHNPHGMKALTDSLLALYGKDRLLTVVFTAMADKDYAGEFSYMSS 360 Query: 348 VVD-DWYCAPLE-GPRGATAEQLLEHLGNGKSFDSVAQAWD---AAMADAKA-EDTVLVC 401 + C + R +A+ L + G F V A + AA+ A+ D V++C Sbjct: 361 RLKIRLICTRVPHNTRCESAQVLAQKAT-GYPFIDVPLAVEDPVAALEKARGFSDPVILC 419 Query: 402 GSFHTVAHVMEVI 414 GS + + + + Sbjct: 420 GSLYFIGSMRSRL 432 >UniRef50_A6DMK1 Folylpolyglutamate synthase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DMK1_9BACT Length = 423 Score = 411 bits (1057), Expect = e-113, Method: Composition-based stats. Identities = 127/417 (30%), Positives = 192/417 (46%), Gaps = 25/417 (5%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 + YL++L I LGLE + + LG + VAGTNGKG+TC + + Sbjct: 6 TFSDAEKYLDSLLVFGIKLGLENMIQLNQLLGDPASSLKFVHVAGTNGKGSTCAMIATAC 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD------ISLTYFE 125 AG K G YSSP LV + ER R+ G + ES + + +I + + + TYFE Sbjct: 66 KYAGLKTGFYSSPFLVNFLERWRINGSPINESIYLDAMQKIIAIEDELVERTGVKPTYFE 125 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 T +AL +FK+ + +VVI E G+GGRLDATNI + + ++T+IA+DH +LG E + Sbjct: 126 VLTAAALLIFKEEKCEVVIWETGMGGRLDATNIANPLLTIITNIAMDHGSYLGDTLEEVA 185 Query: 186 REKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG 243 +EKAGI + + P I GE PE+ A+ A + ++ + D D + Sbjct: 186 KEKAGIIKDQVPLICGERKPELRKLFAESAN--NSTQYFIDSDFTSAQVDDDILYQGKQE 243 Query: 244 TLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 N L L+ + + AL L GL S G+ A PGR Q + Sbjct: 244 I--NYKLRLLGEHQVSNSSLAIKALEVLEDQGLLESAQIAARGLQYAHWPGRIQKLPND- 300 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 + D AHNP A E L+ + N + + GM+ DK+I TL L + + P+ Sbjct: 301 -IYVDGAHNPAAMEKLS----SCFPNKKFTVICGMMEDKEIIPTLEKLVPICTKFIAVPI 355 Query: 358 EGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 + PR A+ L N S + + VL+ GS + V+ + Sbjct: 356 KIPRAIKAQDLA-ISANTVLSCSCESSSSWEETLKQISGPVLITGSLYLSGEVLSKL 411 >UniRef50_A8RZ26 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RZ26_9CLOT Length = 477 Score = 410 bits (1056), Expect = e-113, Method: Composition-based stats. Identities = 126/441 (28%), Positives = 193/441 (43%), Gaps = 30/441 (6%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L +LE +GL+ + + L + +AGTNGKG+ L SI Sbjct: 36 MDFDGALDFLEQRSGLGSVMGLDSIRNLLRELSDPQKDLEFVHIAGTNGKGSVSACLSSI 95 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------LTYF 124 L AG + G Y+SP ++ ER +V G + E +++A G + T F Sbjct: 96 LKEAGCRTGTYTSPAVISVRERYQVDGSWITEREFALLADRVKAAAGRMEEKGRGIPTVF 155 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRES 183 E T A FK+ VV+LE GLGG DATN+V+ + AV TSI++DH LG Sbjct: 156 EIETAMAFLYFKEKGCRVVVLETGLGGEQDATNVVENTLAAVFTSISMDHMGVLGNTLGQ 215 Query: 184 IGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRG------------VEWNY 229 I KAGI + + E+ S + D A EKG + + E Sbjct: 216 IAACKAGIIKPGCEVVSAHQPLEVLSVLKDRAGEKGCVFTQVDMSSLSALSCPEREENRG 275 Query: 230 SVTDHDWAFSDAHGTLENLPLPLVPQPN---AATALAALRASGLEVSENAIRDGIASAIL 286 ++ + + G +LP N A A +AL G+ + E+A+R G+++ Sbjct: 276 EYAENVFTYKAMEGIRISLP-GTYQLENGALALEAASALSRKGIHIPESAMRKGLSNVSW 334 Query: 287 PGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLK 346 PGRFQ++ +SP VI D AHN AA L ++ R++ ++G+ DK+ + Sbjct: 335 PGRFQMLKKSPMVIVDGAHNRDAALRLRECVETCLNGRRLIFIMGVFGDKEYGLMTQIMA 394 Query: 347 SVVDDWYCAPLEGP-RGATAEQLLEHLGNG----KSFDSVAQAWDAAMADAKAEDTVLVC 401 + + Y L R E L G ++ DSV A D A+ DA + VLV Sbjct: 395 PLAERIYTVWLPDRGRSLNPEILAREAGKYCAGTQAVDSVETALDMALKDAGEQGAVLVF 454 Query: 402 GSFHTVAHVMEVIDARRSGGK 422 GS + +M+ + R + Sbjct: 455 GSLSYLGQIMKETERRNRDDR 475 >UniRef50_Q8K9X3 Dihydrofolate synthase n=1 Tax=Buchnera aphidicola (Schizaphis graminum) RepID=FOLC_BUCAP Length = 418 Score = 410 bits (1056), Expect = e-113, Method: Composition-based stats. Identities = 185/409 (45%), Positives = 266/409 (65%), Gaps = 4/409 (0%) Query: 12 PLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESIL 71 + W+ YLE K L + L+A +LG+L F FTV GTNGKGTTC LE +L Sbjct: 7 TFSMWMKYLEKFDKKDRK-NLFELKLIAKKLGLLNLKSFFFTVGGTNGKGTTCAMLEKLL 65 Query: 72 MAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSA 131 + +GY+VG+Y+SPHL+ Y+ER++V G L E H SF I++ +G++SLTYFE+ TLSA Sbjct: 66 LDSGYQVGLYTSPHLINYSERIKVNGLYLSEKDHIFSFLIIDAEKGNVSLTYFEFITLSA 125 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 L+LF Q LD++ILEVGLGGRLDATNI+D+D++V+T+I +DHT LG DR SIGREK+GI Sbjct: 126 LFLFSQYSLDIIILEVGLGGRLDATNIIDSDLSVITNIGIDHTSCLGTDRISIGREKSGI 185 Query: 192 FRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-HDWAFSDAHGTLENLPL 250 FR K A++GE +P ++ ++A+EK +L++ V+W ++ T W F ++ L NLP+ Sbjct: 186 FRKGKIAVIGEKNIPISVDEIAKEKKTILKKIDVDWFWTRTKIDSWNFIHSNIELYNLPV 245 Query: 251 PLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAA 310 +P N A ALA+L SGLEV+ ++ I+ L GRFQ V SPR+I DVAHN HAA Sbjct: 246 SRIPLSNTAIALASLFYSGLEVNLKKLKSSISKVQLSGRFQTVFNSPRIILDVAHNVHAA 305 Query: 311 EYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLE 370 YL+ ++ + G++ AV G+L DKD+AG + L+ ++ WY L+ R A+ L + Sbjct: 306 LYLSEKIDEIDTEGQIYAVFGILKDKDVAGVVQVLQKKINYWYVVNLKTNRSASINYLKK 365 Query: 371 HLG--NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 L N F+++ ++W A +D +LV GSF TV+ M + D R Sbjct: 366 KLSLNNALFFNNINESWQAIKKVITKKDIILVFGSFFTVSEFMSIKDRR 414 >UniRef50_B1YJU6 FolC bifunctional protein n=2 Tax=Exiguobacterium RepID=B1YJU6_EXIS2 Length = 416 Score = 410 bits (1055), Expect = e-113, Method: Composition-based stats. Identities = 124/419 (29%), Positives = 197/419 (47%), Gaps = 22/419 (5%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 L +L L + I GL R+ + A L + A VAGTNGKG+T L Sbjct: 1 MRTREDVLEWLSALLAFGIKPGLSRMEALLAELMIDPDAIPTIHVAGTNGKGSTVAFLRE 60 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL-----TYF 124 + +A G +VG ++SP+++++ ER+ + G + E+ + +++A + T F Sbjct: 61 MGVAEGLQVGTFTSPYIIQFEERIMLNGVPISEADLVEAANVVQAAILKLEPVIGALTEF 120 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRES 183 E T+ A + F Q + D VI EVGLGG D+TN++ A++TSI DH LG + Sbjct: 121 EALTVLAFYHFYQIRPDFVIYEVGLGGLYDSTNVLKQPKAAIITSIGHDHQAILGDTLQE 180 Query: 184 IGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALL---QRRGVEWNYSVTDHDWAF 238 I +K GI + I G + E+ + ++ A L Q ++ S T + Sbjct: 181 IALQKFGIIKQGTRVIAGKLQEELTVPLMAYCGDRQASLSWSQEVIRDYRLSATGTWATY 240 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 T L + NAA A+ + G S+ AIR G+ +A PGRF+I+S PR Sbjct: 241 EGIPETRLGLE-GMHQVHNAANAVVCAKQLGW--SKTAIRRGLRNATHPGRFEIISRKPR 297 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 +I D AHNP L R+K ++ V+ + +L DKD L L+ V D Y + Sbjct: 298 IILDGAHNPEGVTALVERLKE--ESKPVVVLCSILRDKDRKAMLRQLREVTPDIYETTFD 355 Query: 359 GPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 PR T E+L +S + D A + T++V GS + ++ V ++ A+ Sbjct: 356 FPRARTLEELEMDGAKAMELNSFFKEVDTA------DKTLIVTGSLYFISTVRTLLKAQ 408 >UniRef50_C7JGW9 Bifunctional protein FolC n=8 Tax=Acetobacter pasteurianus RepID=C7JGW9_ACEP3 Length = 445 Score = 410 bits (1054), Expect = e-113, Method: Composition-based stats. Identities = 141/422 (33%), Positives = 202/422 (47%), Gaps = 26/422 (6%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCRTLESILMA 73 + L L NL+ IDL L R+ + A+LG + V VAGTNGKG+TC TL +I A Sbjct: 19 AVLERLNNLYPALIDLSLGRLEALLAKLGHPEEKLPPVIHVAGTNGKGSTCATLRAIGEA 78 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALW 133 AG++V V +SPHLV TER R+ G+ + ES A+ EIE +T FE T + Sbjct: 79 AGWRVHVMTSPHLVDVTERFRIAGKLVSESELVATLEEIEQVNDGAPITVFEVLTAAGFL 138 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 LF + D+ I+EVGLGGR DATN++ +VTS++ DH +LG E+I EKAGIF Sbjct: 139 LFSRHPADMAIIEVGLGGRCDATNVLRKPAACIVTSVSRDHEAFLGDTLEAIAGEKAGIF 198 Query: 193 RSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDH------DWAFSDAHGT 244 + PA+ G + + A + GA L RRG EW+ S + + F+D G Sbjct: 199 KPGVPAVTGNQPEAVMKVLQAQADKVGAPLYRRGAEWSISPQNDAESDTAELRFADKAGE 258 Query: 245 L---ENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQ--------IV 293 L + + N A+ ALR SGL V E A GI P R Q + Sbjct: 259 LTLPQPALVGAWQVENVGLAVEALRVSGLHVPEQAW-QGIGRVNWPARMQQLHGKLASHL 317 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 E + D HNP A L + A K+ + ++GM KD G L + + Sbjct: 318 PEGWELWLDGGHNPGAGNALAQEL-AHWKDQPLHVLVGMKQTKDATGFLNPVLPFASSVW 376 Query: 354 -CAPLEGPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMADA-KAEDTVLVCGSFHTVAHV 410 + E ++E G + ++ +A DA +A + VL+CGS + Sbjct: 377 AICEPQQHLALPVEAIVEASGGKAQIGPTLVEALDALVAQNPQQHARVLICGSLYLAGVA 436 Query: 411 ME 412 ++ Sbjct: 437 LK 438 >UniRef50_B4RCL3 Bifunctional dihydrofolate synthase/folylpolyglutamate synthase n=4 Tax=Caulobacteraceae RepID=B4RCL3_PHEZH Length = 444 Score = 410 bits (1054), Expect = e-113, Method: Composition-based stats. Identities = 122/422 (28%), Positives = 183/422 (43%), Gaps = 23/422 (5%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCRTLESILM 72 + + L H IDL RV + A L + V VAGTNGKG+T L +I Sbjct: 15 DAVIQRLRRSHPTLIDLTTGRVERLLAALDHPERRLPPVIHVAGTNGKGSTVAYLRAIGE 74 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AAG +V +SPHLVR+ ER+R+ G+ + + A +E+A D +++FE T+ AL Sbjct: 75 AAGLRVHTLTSPHLVRFAERIRLAGRLISDEQLLALTERVEAANADQPISFFEITTVLAL 134 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 F + D+ ++EVGLGGR DATN+ D V+V+T + DH + LGP I EKAGI Sbjct: 135 LAFAETPADLCVVEVGLGGRFDATNVFDAPAVSVITPVDYDHLEMLGPGLAKIAWEKAGI 194 Query: 192 FRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 + +P +V E I A ++ A + G +++ L+ P Sbjct: 195 IKRGRPVVVARQLDEALEMIEREADDRMAPMLLMGRDFDAWEERGRLLVQMPERLLDLPP 254 Query: 250 LPLVPQPN---AATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPR-------- 298 L A A+AA ++ + + DG+ASA+ P R Q ++ P Sbjct: 255 PSLFGGYQFANAGLAVAAALTFDHDLPDEVLGDGVASAVWPARMQRLTAGPLFELARARG 314 Query: 299 --VIFDVAHNPHAAEYLTGRMKAL--PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 + D HNPHA L + + V GM KD G + Sbjct: 315 ADIWLDGGHNPHAGRALAEAASRIVDRDPRPLTLVAGMFARKDAEGFFRPFAEMKPRVIA 374 Query: 355 APLEGPRGATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 + P+ A+AE + + +V A A++ VLVCG H V Sbjct: 375 TTFDSPQAASAEDIAVAAVKAGLPAEMSPNVEDAVRRALSVDGPAPHVLVCGGLHFAGEV 434 Query: 411 ME 412 + Sbjct: 435 LA 436 >UniRef50_D1N952 FolC bifunctional protein n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N952_9BACT Length = 432 Score = 409 bits (1053), Expect = e-113, Method: Composition-based stats. Identities = 128/423 (30%), Positives = 194/423 (45%), Gaps = 26/423 (6%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 YL++L I GLE + R G +AGTNGKG+T LE L +AG+ Sbjct: 8 EYLDSLTMFGIKPGLEATVELMNRAGNPDRDLKFIHLAGTNGKGSTGAMLECALRSAGFT 67 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEI-----ESARGDISLTYFEYGTLSAL 132 G YSSPHL+ ER RV G+ +P+ A AE+ + D TYFE+ T+ A Sbjct: 68 TGFYSSPHLIDIRERFRVNGRAVPQGDFDAYAAELAEAARRNTGRDFRFTYFEFTTVLAA 127 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 +F +A +DVVI E G+GGRLD+TN+V+ V+T+IALDH +LG + I EKAGI Sbjct: 128 LIFARAGVDVVIWETGMGGRLDSTNVVNPIATVITNIALDHQAYLGDTIDKIAWEKAGII 187 Query: 193 RSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSV---TDHDWAFSDAHGTLEN 247 + P G E + D A++ GA G E + T + + Sbjct: 188 KPAVPLFYGVMPEEARQVLLDRARQLGAAPTGPGPETAGRLHYKTANGMTVQEFEYEGRR 247 Query: 248 LPLPLV---PQPNAATALAALR--ASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 + LPL+ + N L+ S + + DG+A+ P R Q ++E R+ D Sbjct: 248 VRLPLLGAMQRRNFRVVYPVLKFMQSRYGLDLDRALDGLANVRWPARCQQLNE--RLFVD 305 Query: 303 VAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR- 361 HNP L ++ + V DKD+AG+L + V ++ PL Sbjct: 306 GGHNPDGLAALCEALQEAAPGEKFRIVFAGFRDKDVAGSLKLIAPVAAEFVFVPLHEADR 365 Query: 362 -GATAEQLLEHLGNG-----KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + E+L + ++ ++ A + A+ A ++ VLV GS + V+ + Sbjct: 366 PCYSGEELCKLAAECCSVPSRAAENALLAVNDAL--ADSKCRVLVAGSLYLAGEVLSGMA 423 Query: 416 ARR 418 RR Sbjct: 424 DRR 426 >UniRef50_A1U0X0 FolC bifunctional protein n=3 Tax=Marinobacter RepID=A1U0X0_MARAV Length = 438 Score = 409 bits (1052), Expect = e-112, Method: Composition-based stats. Identities = 175/416 (42%), Positives = 243/416 (58%), Gaps = 8/416 (1%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P + + WL +LE +H IDLGL+RV +V RL KP + TVAGTNGKGTT Sbjct: 16 PARGASVQEWLHWLEAIHPTEIDLGLDRVLVVLRRLFPRKPQARIITVAGTNGKGTTVTA 75 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 LESIL+AAG G Y SPHL RY ERVR+ GQE+ ++A +F +E+AR ++LTYFE+ Sbjct: 76 LESILLAAGRSTGAYVSPHLFRYNERVRIGGQEISDAALVTAFERVEAARRGVTLTYFEF 135 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 GTL+A F A ++ +LEVGLGGRLDA N++D D AV+TS+ +DH +LG +RE IG Sbjct: 136 GTLAAFVAFAGAGVENWVLEVGLGGRLDAVNVLDPDYAVITSVDIDHIGFLGDNREVIGF 195 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 EKAGI R PA+ +P PS++ A + L+ G ++ + Sbjct: 196 EKAGILRPGIPAVCADPNPPSSVLQQAAAQKVALKLTGRDYTLAPGAPGQVLLTIGDEKI 255 Query: 247 NLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHN 306 LP +P + A A R E+S +++ I + +PGRF+ + P VI DV HN Sbjct: 256 ELPAGPLPVQSVAAAAVLSRQLVPELSLESLQHAIQNVRVPGRFETIHHDPDVIIDVGHN 315 Query: 307 PHAAEYLTGRMKALPKN--GRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGAT 364 PHAA +L ++ L GR+LAV G L DKD+ G + + SVVD WY A L+ PRG Sbjct: 316 PHAAAWLADNLRRLRCGGPGRILAVYGALGDKDVEGVVGAMSSVVDQWYLAGLDVPRGLD 375 Query: 365 AEQLLEHLGNG------KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 ++ L++ + +F SV++A AAM AK+ D ++V GSF TVA E + Sbjct: 376 SDSLMKRISTVALQGKPGAFGSVSEALAAAMKAAKSGDRIVVFGSFFTVALAREEL 431 >UniRef50_A8YUM7 Folylpolyglutamate synthase n=28 Tax=Lactobacillus RepID=A8YUM7_LACH4 Length = 424 Score = 408 bits (1050), Expect = e-112, Method: Composition-based stats. Identities = 111/419 (26%), Positives = 195/419 (46%), Gaps = 13/419 (3%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 + YL +L L + + +LG + + GTNGKG+T L +++ Sbjct: 7 EEVIHYLYSLPHVHPKNDLSFIKKLLQQLGNPQDQVKTIHITGTNGKGSTSYYLANLVKK 66 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHT-------ASFAEIESARGDISLTYFEY 126 AG + G++ SP++ R+ ER+++ Q++ + A++ +++ SL FEY Sbjct: 67 AGQRTGLFVSPYVYRFNERIQLNNQDISDEDLVNVANTVQAAYEKLKQEDEQFSLVTFEY 126 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 A F+Q Q D ++EVG+GG D TN++ +V+++T+I LDH +GP + I + Sbjct: 127 EVAMAFVYFEQKQCDYAVIEVGIGGEHDKTNVIIPEVSIITTIGLDHEKIIGPTIQDIAQ 186 Query: 187 EKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 EK+GI + +P ++G + S + A + A L + ++ + +SDA + Sbjct: 187 EKSGIIKQNRPVVLGNVPDSVLSILVKKADKMHAPLLQLKHDFTIETQNGRLKYSDAKRS 246 Query: 245 LENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVA 304 L P V + A A+ A L +++ I D I +PGR+ I+ + P +I D A Sbjct: 247 LSFAYRPQVEGYDIAVAVKAFLLLKLNLNDQEIEDAINQTQIPGRYHILQKEPLIILDGA 306 Query: 305 HNPHAAEYLTGRMKALPKNG--RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRG 362 HN A L + A K V A++ M+ DKD+ + L + D L+ PR Sbjct: 307 HNIQAMSNLLEVVHAEAKKRHSHVYALVTMMKDKDLEQVFS-LFNKDDQVLLTTLDYPRV 365 Query: 363 ATAEQLLEHLGNGKSFD-SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSG 420 A + S++ Q + A D +LV GSF+ V+ ++ +G Sbjct: 366 AKENDFPIDIQRRYSYEGDYRQGFTKLKEKMDASDILLVTGSFYLVSAILNWKGKGNAG 424 >UniRef50_A0LA36 FolC bifunctional protein n=2 Tax=cellular organisms RepID=A0LA36_MAGSM Length = 426 Score = 408 bits (1049), Expect = e-112, Method: Composition-based stats. Identities = 125/425 (29%), Positives = 193/425 (45%), Gaps = 21/425 (4%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP-FVFTVAGTNGKGTTCRTL 67 + S L + L+ E+ I+L L R+ + +G + V VAGTNGKG+ Sbjct: 4 SLSVLDALLAQSESRADCIIELKLARMLDLLQAMGNPQRRLGPVVHVAGTNGKGSVIAFF 63 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 +IL AG V Y+SPHLV ER++ G + ++ ++ + T+FE Sbjct: 64 GAILRQAGRSVAAYTSPHLVTIHERIQYNGVPVEDALLRYYAQQVLALPQSQQATFFERL 123 Query: 128 TLSALWLFKQAQLD----VVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 T +A + Q VV+LE GLGGRLDATN+V + +T++ LDH +LG Sbjct: 124 TATAFAVMAHWQASDPSLVVVLETGLGGRLDATNVVQPVLTAITAMGLDHQSYLGTSMAQ 183 Query: 184 IGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNY--SVTDHDWAFS 239 I +EKAGI ++ PA++ E + + AQ+ GA +Q G ++ + + W +S Sbjct: 184 IAQEKAGILKAGVPAVLAPAQDEALAVLVQQAQQVGAPVQVAGQDYRWGQNNEGAGWWYS 243 Query: 240 DAHGTL---ENLPLPLVPQPNAATALAALRAS---GLEVSENAIRDGIASAILPGRFQIV 293 D G L E L N A A+A +R G V +A G+ + PGR + V Sbjct: 244 DGVGQLMLPEPGLLGAHQYHNGAQAVAMVRQLVAQGWSVPSSAYAAGLTAVRWPGRLERV 303 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 ++P V D AHNP A+ + + + ++ DKD+AG L +V Sbjct: 304 GDAPEVWLDGAHNPAGAQVCADFFRQY--GRVDVMLFALMADKDVAGMLEPWLELVKTVV 361 Query: 354 CAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAH 409 G R AE L + ++ S Q W A A +LV GS + V Sbjct: 362 VVEPVGGRSMAAEGLAQAWRAVGVTAETAPSTEQGWQLARKKAGHAGKILVSGSLYLVGE 421 Query: 410 VMEVI 414 V +++ Sbjct: 422 VKKLL 426 >UniRef50_B5IFG1 FolC bifunctional protein n=2 Tax=Aciduliprofundum boonei T469 RepID=B5IFG1_9EURY Length = 422 Score = 408 bits (1049), Expect = e-112, Method: Composition-based stats. Identities = 117/420 (27%), Positives = 181/420 (43%), Gaps = 28/420 (6%) Query: 17 LSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGY 76 + Y+ NL + L L + A G + +AGTNGKG+ + SIL Y Sbjct: 6 IEYIYNLRRFGMKLDLSIMREFAEIRGNPQDKFKSVHIAGTNGKGSVASAIYSILRK-NY 64 Query: 77 KVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-----SLTYFEYGTLSA 131 VG+Y+SPHLVRY+ER+ V +E+ E E++ ++ + T+FE T+ A Sbjct: 65 NVGIYTSPHLVRYSERIIVNDREISEDYIARFVREVKPIIEELAKENRNPTFFEVSTMLA 124 Query: 132 LWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGI 191 F +D +LEVGLGGRLDATNIV ++ + +I LDHT LG I REKAGI Sbjct: 125 FEYFSYMSVDFAVLEVGLGGRLDATNIVMPEITSIVTIDLDHTHILGDTIRDIAREKAGI 184 Query: 192 FRSEKPAIVGE--PEMPSTIADVAQEKGALLQ-----RRGVEWNYSVTDHDWAFSDAHGT 244 + P ++GE E I +A+ + A + + + + T Sbjct: 185 IKPNVPVVIGENKKEAIEEIKRIAELRNAPYHNIWDEMEFEDVHIDLNGLRFKAHTPIST 244 Query: 245 LENLPLPLVPQPNAATALAALR-----ASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 + PL + L A+R +S + I DGI + RFQ+ P + Sbjct: 245 Y-TIETPLPGKHQITNMLVAIRIAELLQENYSISHSDIEDGIKNIKWKDRFQVKRRRPLL 303 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 IFD AHNP AA L ++ + + +L DK+I L + V ++ Sbjct: 304 IFDSAHNPSAARALVSTIRDVGIEEP-TFLFSILSDKNIDEFLKEISKVSKKIIVTEIDY 362 Query: 360 PRGAT-----AEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 R T E ++ + A AM E ++ GS + + + + + Sbjct: 363 ERRRTELEDIVEHAKKYFSEVIPIKNPCDALKYAME---NEKKIIATGSIYLLGELEKCL 419 >UniRef50_Q49Y95 Folylpolyglutamate synthase n=66 Tax=Staphylococcaceae RepID=Q49Y95_STAS1 Length = 424 Score = 408 bits (1049), Expect = e-112, Method: Composition-based stats. Identities = 103/425 (24%), Positives = 182/425 (42%), Gaps = 20/425 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L ++ I G++R+ + RL + V GTNGKG+T L S L+ Sbjct: 3 YLDSLYWIHERTKFGIKPGVKRMEWMLERLNNPQFNINGIHVGGTNGKGSTVSYLRSALV 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL-------TYFE 125 GY+VG ++SP + + ER+ + G + + A ++ + + T FE Sbjct: 63 DNGYEVGTFTSPFIETFNERISLNGNPISDDEIVALVQHVKPVSEALEIETELGTATEFE 122 Query: 126 YGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 T F + +D VI+E GLG + D+TN+ ++++TSI LDHTD LG I Sbjct: 123 IITTMMFLYFGEIHPVDFVIVEAGLGIKNDSTNVFKPILSILTSIGLDHTDLLGDTYVDI 182 Query: 185 GREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 ++K I + P I E I D +++ A + + D ++ + Sbjct: 183 AKDKGAIVKPNTPVIYAVKNDEALKVIRDYVEQQEAEGIELDRDISIISEDEEFTYRYKD 242 Query: 243 GTLENLPLPL---VPQPNAATALAALRASG----LEVSENAIRDGIASAILPGRFQIVSE 295 LE L L + + NAA A+ AL +++ N + DGI S GR + V + Sbjct: 243 YELETLLLNMVGEHQKENAALAITALIELNEDGIVDLDFNKMIDGIESVSWTGRIEQVKD 302 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 P +I D AHN + E L +K + + + K I + LK++ +Y Sbjct: 303 QPLMIMDGAHNVESVEALISTIKQYYNIENIDILFSAIKGKPINAMVDQLKTIASTFYIT 362 Query: 356 PLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVID 415 + P+ T E++ E + ++ + + + E + + GS + ++ V ++ Sbjct: 363 DFDFPKALTKEEIFEDVR--YDQKALVDDYVKFIETYEGEGLI-ITGSLYFISEVKSKVN 419 Query: 416 ARRSG 420 S Sbjct: 420 FNESN 424 >UniRef50_A4A847 Folylpolyglutamate synthase/dihydrofolate synthase n=2 Tax=unclassified Gammaproteobacteria RepID=A4A847_9GAMM Length = 428 Score = 407 bits (1048), Expect = e-112, Method: Composition-based stats. Identities = 160/418 (38%), Positives = 231/418 (55%), Gaps = 9/418 (2%) Query: 9 AASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLE 68 L WL YLE LH IDLGL RV A +L + P V TVAGTNGKG+ E Sbjct: 2 PERSLGEWLRYLEQLHPVDIDLGLARVRKAAEQLALFPYGPEVITVAGTNGKGSVVFGTE 61 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 IL A G + G Y+SPHL+ + ER+ V G + + A+F IE+ARGD++LTYFE+ T Sbjct: 62 CILRAHGRRTGRYTSPHLLSFNERIAVDGCPVSDGQIVAAFDAIEAARGDVTLTYFEFAT 121 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+A W+F++ ++DV ++EVGLGGRLDA N+VD+D+AV+T+I LDH WLG E I EK Sbjct: 122 LAAYWIFRELRVDVAVMEVGLGGRLDAVNLVDSDIAVITAIDLDHQHWLGDTVEQIAPEK 181 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENL 248 A I R +P ++ E + P T+ + GA+ R G EW++ H + Sbjct: 182 AAIARPGRPVVLAEADYPDTLFHTLDDIGAVPLRAGREWSWRYEGDLQLSLKDHRESITV 241 Query: 249 PLP-LVPQPNAATALAALR-ASGLEVSENAIRDGIASAILPGRFQIVSESPR-VIFDVAH 305 PLP + N AL A + G R+ + + +P R Q +S + R ++ DVAH Sbjct: 242 PLPDGLRPSNLGAALQASAVSLGQTFDPQKSREALRTLSVPARRQTISFAGRALLLDVAH 301 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-PRGAT 364 NP A L +KA P G+ A +G++ DKD+AG A L + VD + G R A Sbjct: 302 NPAAMVALVEHLKARPVPGKTFAALGLMKDKDLAGMAASLATAVDGACALAIPGIDRAAA 361 Query: 365 AEQLLEHLGNGKSF----DSVAQA-WDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 E + + L + + A A W + + A D +++CGSF++VA +ME+++ Sbjct: 362 PEAVWQALDDVGIAIPQGEFTADAVWSQLLDGSAAGDRLVICGSFYSVAGIMELLNIE 419 >UniRef50_Q89AT2 Dihydrofolate synthase n=4 Tax=Buchnera aphidicola RepID=FOLC_BUCBP Length = 426 Score = 407 bits (1048), Expect = e-112, Method: Composition-based stats. Identities = 181/425 (42%), Positives = 265/425 (62%), Gaps = 4/425 (0%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 MI K+ ++ L WL YL++ ID L RV VA +LGVLK FVF V GTNGK Sbjct: 1 MINKKLARSF-SLYEWLYYLDHFMLDNIDPTLNRVFYVAKKLGVLKSKAFVFIVGGTNGK 59 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 G+TC LE++L+ +GY+VG+Y+SPHL+RYTERVR+ G EL H ++F +++ + D+ Sbjct: 60 GSTCHVLENLLLNSGYRVGLYTSPHLMRYTERVRINGFELEHLYHISAFNDVKYFQNDVL 119 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 LT FE+ TLSAL LFK LD++ILEVGLGGRLDATNI+ ADV+V+T+I +DH+ LG + Sbjct: 120 LTRFEFITLSALILFKSYNLDIIILEVGLGGRLDATNILSADVSVITNIDIDHSKILGVN 179 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD 240 R SI EK+GIFR K AIV + P +A++K L+ ++W Y + +W+F Sbjct: 180 RSSISVEKSGIFRKNKIAIVADNNFPKVAQYLAKKKKVRLRIVNIDWIYKKIEFEWSFCS 239 Query: 241 AHGTLENLPLP-LVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRV 299 + T +LPLP V + ATAL+A+ SG+++++ R I+ L GRF+ +S +P + Sbjct: 240 SKITWLHLPLPRNVSLDSVATALSAVSESGIKINQKVFRSCISEITLCGRFETISYNPII 299 Query: 300 IFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG 359 I DVAHNPH+A YL +M + KNG + AV+G+L +K+I ++ L +VD WYC L Sbjct: 300 ILDVAHNPHSARYLFKKMSSFKKNGNIFAVVGILKEKNIKDIVSPLIPIVDYWYCITLLT 359 Query: 360 PRGATAEQLLEHLGNG--KSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDAR 417 R AT+ +++++L N + ++ A + D VL+ GSF TV + + + Sbjct: 360 HRSATSSEIIKYLPNHNSQISKNMTVALEKIFDKVTNNDIVLIFGSFITVCEANKFLANK 419 Query: 418 RSGGK 422 K Sbjct: 420 VKNFK 424 >UniRef50_B7ARH5 Putative uncharacterized protein n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7ARH5_9BACE Length = 446 Score = 407 bits (1047), Expect = e-112, Method: Composition-based stats. Identities = 114/444 (25%), Positives = 183/444 (41%), Gaps = 40/444 (9%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 + ++ ++ G E + ARLG + V +AGTNGKG+ C + + Sbjct: 1 MTWEEAVEHINSVSRYGNRPGAECTKALLARLGNPERELKVIHIAGTNGKGSVCMYIAGM 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYF 124 L + G GV++SPHL+R ER+R + + + T F ++ A ++ ++YF Sbjct: 61 LRSLGLNTGVFTSPHLIRENERIRFNDELISDEDFTDCFEKVHRAELELLKDGFGQISYF 120 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRES 183 ++ A+ + + DVVILE GLGGRLD+TN V+ + V+TSI+LDH LG E Sbjct: 121 DFFVGIAMLYYAMKKPDVVILETGLGGRLDSTNAVESPVMTVITSISLDHVAILGDTVEK 180 Query: 184 IGREKAGIFRSEKPAI-VGEPEMPSTIADVAQEKGALLQRRGVEWN--YSVTDHDWAFSD 240 I EKAGI + P + V E I + A+ G + + FS Sbjct: 181 IAAEKAGIIKHGAPVVYVAGQEYSHVIEEKAEAMGIKAAGVEKSQCEIHEIGSKHIDFSL 240 Query: 241 AHGTLENLPLPL-----VPQPNAATALAALRAS-------GLEVSE-------NAIRDGI 281 ++ L NAA A+ A++ + + IR G+ Sbjct: 241 DSIYYKDNVFRLATPAVYQVMNAALAMTAVQMLVESRCFDRIAYDSMDRQNYIDRIRRGL 300 Query: 282 ASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAV--IGMLHDKDIA 339 S GR + V E D AHNP L A+ KN R V ++DKD + Sbjct: 301 ESVTWEGRMEQVCEG--FYIDGAHNPDGIAALLDTAAAMKKNTRGHYVLMFSAVNDKDYS 358 Query: 340 GTLAWLKS--VVDDWYCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADA 392 + + + D++ +EG R ++ + V QA ++ Sbjct: 359 SMIKEICDSNIFDEYVITQIEGARCLDVSKIADTFRRYTDGHVNEEPDVGQAVKKSVECF 418 Query: 393 KAEDTVLVCGSFHTVAHVMEVIDA 416 TV+ GS + V +V+ Sbjct: 419 GGNATVICAGSLYLAGEVRKVMLD 442 >UniRef50_Q1QY39 FolC bifunctional protein n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QY39_CHRSD Length = 437 Score = 407 bits (1047), Expect = e-112, Method: Composition-based stats. Identities = 169/428 (39%), Positives = 232/428 (54%), Gaps = 23/428 (5%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAP--FVFTVAGTNGKGTTCR 65 AA+ L +WL+ LE H IDLGLERV+ VA RL +L V TVAGTNGKG+T Sbjct: 2 TAATSLQAWLARLERQHPVAIDLGLERVAEVARRLALLDTPLATRVITVAGTNGKGSTVA 61 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISL---T 122 LE++ G + Y+SPHL+RY ER+R+ G E ++A F +E+AR D T Sbjct: 62 MLEAVAREHGLRTAAYTSPHLLRYNERLRLAGCEADDAALVEGFEAVEAARLDGDPVTLT 121 Query: 123 YFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 YFE GTL+ALWL + Q DV +LEVGLGGRLDA N++D DVAVVT++A DH +LG + Sbjct: 122 YFEAGTLAALWLIARWQPDVALLEVGLGGRLDAVNVIDPDVAVVTTVAQDHAAFLGTHLD 181 Query: 183 SIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD-----WA 237 +IGREKAGI R+ +PA++G +P+++ + A A + + + + D W Sbjct: 182 TIGREKAGILRAGRPAVLGSTTLPASVRERADALSAPVFALQEAFAWRMGDRGQEGSEWQ 241 Query: 238 FS-----DAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQI 292 + L LP P +P NAA AL L + +++ E A R ++ +L GR Q Sbjct: 242 WQGTAPGGEKVALHGLPDPGLPLDNAAVALQTLALADVKLDETATRRALSRVVLAGRLQW 301 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 + DV HNPHAA Y+ G++ P+ GR L ++GML DKD G +A L +D W Sbjct: 302 M---GPWCLDVGHNPHAAAYVAGQLAQRPRRGRRLCLLGMLADKDADGVIAALAPQIDAW 358 Query: 353 YCAPLEGPRGATAEQLL-----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTV 407 L G R A QL S A+ D +LVCGSF TV Sbjct: 359 VTVSLSGDRARDAAQLATFVEGRGAKVLHQGASPEDGVRWLHANMDNGDDILVCGSFWTV 418 Query: 408 AHVMEVID 415 A + ++ Sbjct: 419 AEALAALE 426 >UniRef50_Q1JHI7 Folylpolyglutamate synthase / Dihydrofolate synthase n=20 Tax=Streptococcus RepID=Q1JHI7_STRPD Length = 430 Score = 407 bits (1047), Expect = e-112, Method: Composition-based stats. Identities = 101/423 (23%), Positives = 180/423 (42%), Gaps = 26/423 (6%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 + +S++ + L R++ + LG + V GTNGKG+ Sbjct: 5 QEIVMTTYDSISWIHTFKANGRKTDLARMAWLLEALGRPQDKFPAIHVVGTNGKGSVTAY 64 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS------ 120 L+ IL +GY+VG ++SP ++ + +R+ + GQ + + + I +S Sbjct: 65 LQHILSTSGYQVGTFTSPFIISFHDRICLNGQPISDLELAQCVSVIRPILTKMSLETNWD 124 Query: 121 -LTYFEYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLG 178 T FE TL F +D+ I+E G+GG+ DATN+ A V SI+ DH + LG Sbjct: 125 RPTEFELVTLIMFCYFANLKPVDIAIIEAGIGGKTDATNVFHALAVVCPSISFDHQERLG 184 Query: 179 PDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDW 236 I +KA + ++++P I+G+ E V Q+ G+ L + G ++ + ++ Sbjct: 185 YSLAEIAHQKAEVIKAKEPVIIGQLEQEASQVFQQVTQKAGSRLYQLGKDFLLNPSEKTI 244 Query: 237 AFSDAHGTLENLPLPLVPQPNAATA------LAALRASGLEVSENAIRDGIASAILPGRF 290 +F + L L L L+ Q A A LR S ++S I+ GI + PGR Sbjct: 245 SFQHDNLNLTKLRLKLLGQHQKANACLTIMTAQLLRKSFPKISPKTIQKGIETTTWPGRS 304 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 + + P ++ D AHNP + L ++ + + L K +A LA L + Sbjct: 305 EFIQ--PNLLLDGAHNPDSIAKLKSLLQEEFPKRPIHILFAGLKRKPLADLLAQLDTF-- 360 Query: 351 DWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 + + P E + K + Q +++ +V GS + ++ V Sbjct: 361 EVSVTTFDFPEANLLEDYPDKYPQVKDYRDWLQG------SVTSDELFVVTGSLYFISEV 414 Query: 411 MEV 413 + Sbjct: 415 RQY 417 >UniRef50_C4V4R4 Possible tetrahydrofolate synthase n=2 Tax=Selenomonas RepID=C4V4R4_9FIRM Length = 433 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 127/431 (29%), Positives = 196/431 (45%), Gaps = 25/431 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L YL+ L++ I LGL R+ + ARLG + + V +AGTNGKG+ + ++++ Sbjct: 3 YEESLHYLDELNTFGIRLGLARMEELCARLGHPERSYRVIHIAGTNGKGSVTQMMDAVCR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEY 126 A+G + G Y SPHLV YTER+ V G+E+ E A + + A G T FE Sbjct: 63 ASGIRSGRYLSPHLVSYTERMSVGGEEIGEEQFAALLTRVSAAADAMTAEGHEHPTQFEA 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T A F + + +V ++E GLGG LD+TN+V ++ ++T++A+DH D G I Sbjct: 123 LTALAFLYFAEEKAEVAVVETGLGGLLDSTNVVLPELTIITNVAMDHADRCGGTLAGIAE 182 Query: 187 EKAGIFRSEKPAIVGEP-EMPSTIADVAQEKGALLQRRGVEWNYSVT--DHDWAFSDAHG 243 KAGI + P I E S IA A+E GA L G +++ + ++ H Sbjct: 183 HKAGIIKEGVPVITAAAGEPLSIIAARAEELGADLFVYGEDFSAQMLRMENGGQCVSFHS 242 Query: 244 TLENLPLPL-------VPQPNAATALAALRASGLE---VSENAIRDGIASAILPGRFQIV 293 + P P NAA A+ A E ++E+A+R + + P RF+I+ Sbjct: 243 VVSRAPEPFEIALAGPYQAENAALAIMAAELMAPEDERITEDAVRTALRTVHHPARFEIL 302 Query: 294 S-ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 S V+ D AHNP + L + A + ++G+L DKDI LA L D Sbjct: 303 SCGGQTVVVDGAHNPAGMQALRAGLDAYFPAQPRVFLLGILKDKDIDRMLAILLRPGDQV 362 Query: 353 YCAPLEGPRGATAE----QLLEHLGNGKSFDSVAQAW-DAAMADAKAEDTVLVCGSFHTV 407 R A A+ + A +A A+ ++ GS + V Sbjct: 363 VTVRPNSERAAGADLVAAVAAGMGAVTHAAGDPAAGLSEALARAHAADALLVAAGSLYLV 422 Query: 408 AHVMEVIDARR 418 + + A R Sbjct: 423 GGIRTRLLAGR 433 >UniRef50_P15925 Folylpolyglutamate synthase n=9 Tax=Lactobacillus RepID=FOLC_LACCA Length = 428 Score = 407 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 113/429 (26%), Positives = 201/429 (46%), Gaps = 25/429 (5%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 ++Y+ + R+ + LG + V GTNGKG+ + +L Sbjct: 3 YTETVAYIHSFPRLAKTGDHRRILTLLHALGNPQQQGRYIHVTGTNGKGSAANAIAHVLE 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-------DISLTYFE 125 A+G VG+Y+SP ++R+ ER+ + + +P++A + A + +A D ++T FE Sbjct: 63 ASGLTVGLYTSPFIMRFNERIMIDHEPIPDAALVNAVAFVRAALERLQQQQADFNVTEFE 122 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIG 185 + T W F+Q Q+DV ++EVG+GG D+TN++ V+V+T +ALDH LG +I Sbjct: 123 FITALGYWYFRQRQVDVAVIEVGIGGDTDSTNVITPVVSVLTEVALDHQKLLGHTITAIA 182 Query: 186 REKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVT-----DHDWAF 238 + KAGI + P + G P+ + +A G+ R +++ + + Sbjct: 183 KHKAGIIKRGIPVVTGNLVPDAAAVVAAKVATTGSQWLRFDRDFSVPKAKLHGWGQRFTY 242 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRASG-------LEVSENAIRDGIASAILPGRFQ 291 D G + +L +PLV A++ + ++ IR G+A++ P R + Sbjct: 243 EDQDGRISDLEVPLVGDYQQRNMAIAIQTAKVYAKQTEWPLTPQNIRQGLAASHWPARLE 302 Query: 292 IVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 +S++P ++ D AHNP L +K L + + G+L DKD A L + Sbjct: 303 KISDTPLIVIDGAHNPDGINGLITALKQLFS-QPITVIAGILADKDYAAMADRLTAAFST 361 Query: 352 WYCAPLEG-PRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 Y P+ G PR E E L G+ DS +A A++ D + +++ GS + + V Sbjct: 362 VYLVPVPGTPRAL-PEAGYEALHEGRLKDSWQEALAASLNDV-PDQPIVITGSLYLASAV 419 Query: 411 MEVIDARRS 419 + + +S Sbjct: 420 RQTLLGGKS 428 >UniRef50_C2BRT3 Possible tetrahydrofolate synthase n=3 Tax=Mobiluncus RepID=C2BRT3_9ACTO Length = 549 Score = 406 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 118/445 (26%), Positives = 200/445 (44%), Gaps = 34/445 (7%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P+A + + L+ I+ LE V V LG + + GTNGK + R Sbjct: 108 PKARAIYETLLTR---RAEHQIEPSLEPVRGVLDYLGNPQELFHSVHITGTNGKTSIARM 164 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-------ARGDI 119 +E++L GY+ G ++SPHLV ER+ + L ++ +IE+ A Sbjct: 165 IEALLAELGYRTGRFTSPHLVDVCERISIDQAPLTTEQFVQAYEDIEAQLALWEHAHPGR 224 Query: 120 SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGP 179 L++FE T+ A LF +DV ++EVG+GGR DATN++DAD AV+ I+L+H WLG Sbjct: 225 RLSFFEVMTVMAYALFADVPIDVAVVEVGMGGRWDATNVIDADTAVIGPISLEHEQWLGK 284 Query: 180 DRESIGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNY-----SVT 232 +I REKAGI R ++ A+V + E + I D A + +L+ G ++ +V Sbjct: 285 GLTNIAREKAGIMRPQRVAVVAKQPDEALAVIRDTAAAEDVVLRYEGEDFEVLRRVPAVG 344 Query: 233 DHDWAFSDAHGTLENLPLPLV---PQPNAATALAALRAS--GLEVSENAIRDGIASAILP 287 +++ LPL NAA AL A+ A G+ + ++ + + P Sbjct: 345 GQVLDIRTPAAVYQDIYLPLYGEFQAENAALALTAVEAQLGGMPLHGESVERALGTVKSP 404 Query: 288 GRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS 347 GR +++ +P ++ D HNP AA+ L ++ + + + + DKDI L ++ Sbjct: 405 GRLEVLHSTPMIVADAGHNPGAAQALRRAIEDDFRFEHTVGIYSAMADKDIETVLGIMEP 464 Query: 348 VVDDWYCAPLEGPRGATAEQLLEHLGN------GKSFDSVAQAWDAAMADAKAED----- 396 + + + G R A E L + + S+ +A A + Sbjct: 465 TIAELIVTQMPGERAAKVEDLQTLAADVFGDERVYAIGSLPEAIAKAGEIDDLQGGVPGS 524 Query: 397 -TVLVCGSFHTVAHVMEVIDARRSG 420 V++ GS +V+ + Sbjct: 525 TGVVIFGSVVLAGMAQDVLRKDKLN 549 >UniRef50_Q3ZAH8 Folylpolyglutamate synthetase n=5 Tax=Dehalococcoides RepID=Q3ZAH8_DEHE1 Length = 439 Score = 406 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 123/432 (28%), Positives = 184/432 (42%), Gaps = 30/432 (6%) Query: 18 SYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYK 77 Y + L RV + RL +AGT GKG+T + S++ AAGY+ Sbjct: 5 DYESATSRAAANYDLRRVVELLLRLHSPHIGIPSVHLAGTKGKGSTAALIASVMSAAGYR 64 Query: 78 VGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-------SLTYFEYGTLS 130 G+Y+SPHL+ + ER+R+ G+ + ++ I ++ +T FE T+ Sbjct: 65 TGLYTSPHLLDFRERIRLDGKMISKAHLVRIMDYISPMVEEMNARTCLGKITSFEVMTVL 124 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAG 190 A F + Q ++E GLGGRLDATN++ +++V+T I+LDHT+ LG I EKAG Sbjct: 125 AFEFFHRQQAFFQVIETGLGGRLDATNVITPNLSVLTPISLDHTEVLGDSLAKISAEKAG 184 Query: 191 IFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWN-----YSVTDHDWAFSDAHG 243 I + P + PE + I + + G+ L + Y+ S Sbjct: 185 IIKHFVPVVSAAQRPEAMAVIRERCLKTGSKLIEVTDSYKAELLGYTAQGQSLKLSGRQA 244 Query: 244 TLENLPLPL---VPQPNAATALAALRAS---GLEVSENAIRDGIASAILPGRFQIVSESP 297 L LPL + NA TALA+L A G ++S I +G PGRF+++ P Sbjct: 245 EY-RLCLPLLGHYQRQNALTALASLEALVEEGFKISNEDIAEGFGQVRWPGRFKVIKGKP 303 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPK-----NGRVLAVIGMLHDKDIAGTLAWLKSVVDDW 352 ++ D AHN AA L ++ P + L V G DKD L Sbjct: 304 LMVIDGAHNQEAAAELLLSLQEYPPAAKVEKEKRLLVFGTSFDKDAGAMADVLSGYFGTV 363 Query: 353 YCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 PR + L + D V +A + A A A+ V V GS A Sbjct: 364 ILTHSLHPRAMKPDLLRKAFDGRGLKVLEADGVPKALELAGRIAPADGLVCVAGSLFVAA 423 Query: 409 HVMEVIDARRSG 420 ++ RSG Sbjct: 424 EALKGQSQPRSG 435 >UniRef50_Q31PP5 FolC bifunctional protein n=2 Tax=Synechococcus elongatus RepID=Q31PP5_SYNE7 Length = 412 Score = 406 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 132/410 (32%), Positives = 202/410 (49%), Gaps = 12/410 (2%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 LA L + + +DLGL+R V RLG + + +AGTNGKG+TC +++ Sbjct: 1 MSLAELDRLLGSFAQRGVDLGLDRSLTVLERLGNPQNQIPIVHIAGTNGKGSTCAFVDTA 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLS 130 L A GY+VG Y+SPHL+ + ER+++ GQ++ + + +A I LT FE T + Sbjct: 61 LRANGYRVGRYTSPHLISWCERLQLNGQQVSSDRLLEAVQTVLAAADGIDLTPFELLTAA 120 Query: 131 ALWLFKQAQLDVVILEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKA 189 + + LD+V++E GLGGRLDATN+V V +TSI DH LGP +I EKA Sbjct: 121 VWLVLADSDLDIVVIETGLGGRLDATNVVAQPLVTAITSIGHDHQAVLGPTLGAIAAEKA 180 Query: 190 GIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 GI +S P +VG PE + I + A++ AL+ + T ++ Sbjct: 181 GIIKSRCPVVVGPLLPEARTVIRNRAEQLQALMIAIEPATVIESG----LWQSQGLTYQS 236 Query: 248 LPLPLVPQPNAATALAALR---ASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIFDV 303 + V + N+A A+A LR G + + AI G+A PGR Q + + R++ D Sbjct: 237 GLIGDVQRINSAIAIAILRQLQQQGWGLQDAAIAQGLADTDWPGRLQWLDYQGRRLLIDG 296 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGA 363 AHNP AA L + L N + +IGML KD LA L D P+ Sbjct: 297 AHNPEAAIALRQAVDQLLPNQSITWLIGMLRAKDAQAVLATLLRSGDRCIAIPVPDHDCW 356 Query: 364 TAEQLLEHLGNGKSFDSVAQAWDAAMADAKA-EDTVLVCGSFHTVAHVME 412 ++E+L + S A W +A A+ + ++ CGS + + ++ Sbjct: 357 SSEELQTWAAAQGAIASTAADWAEGLAIAQTYPEAIVFCGSLYLLGDFLQ 406 >UniRef50_D2LRU4 FolC bifunctional protein n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2LRU4_BACS4 Length = 426 Score = 406 bits (1044), Expect = e-112, Method: Composition-based stats. Identities = 103/424 (24%), Positives = 181/424 (42%), Gaps = 19/424 (4%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + + + Y+ + I L+R+ + L + VAGTNGKG+T L S Sbjct: 2 ITTYKNAIDYVNSKRVAGIRYDLKRMEKLMEALNHPERKVKTIHVAGTNGKGSTVTFLRS 61 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTY 123 +L AG+ VG Y +P E++ + G+ + ES T +EI D ++ Sbjct: 62 MLQEAGFFVGTYMTPSFGDVREQIAINGEPMSESQFTTMISEIAPTVAVVEQEMDELISE 121 Query: 124 FEYGTLSALWLFK-QAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 FE T AL+ F ++ +D+ ++E G+GGR DATN++ V+V+T++ DH ++LG + Sbjct: 122 FELITALALYYFSFKSPVDIAVIEAGMGGRNDATNVIFPLVSVITNVGYDHQEYLGDSLK 181 Query: 183 SIGREKAGIFRSEKPAIVG-EPEMPSTIADVAQEKGALLQ----RRGVEWNYSVTDHDWA 237 I +EKAGI + + + + + A+EK + L R E + + Sbjct: 182 EIAKEKAGIIKPGVAVMTACDSNIQFVFEEEAKEKRSSLYALQSRITYETSLEADTQTLS 241 Query: 238 FSDAHGTLENLPLPLVPQPNAATALAALRASGLE-------VSENAIRDGIASAILPGRF 290 + A+ L+++PL L+ A AL V++ G++ A L GRF Sbjct: 242 YEAAYRKLKHVPLKLLGDHQGKNAALALMTIDYLHQFYALMVTDEQAVAGLSKAQLAGRF 301 Query: 291 QIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 +I+ P ++ D AHNP A E +K + + + + DK+I + L+ Sbjct: 302 EIIDTIPVIVLDTAHNPPAIEKTLETVKKRFREKEITVLFAAMKDKEIKTMIEQLEGATS 361 Query: 351 DWYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 + PR + + +AW + VL+ GS + + Sbjct: 362 KLFVTTFSSPRALPLSDFEQFGIHENQLVEHPKAWMKDYVINNESNIVLITGSHQFINDM 421 Query: 411 MEVI 414 Sbjct: 422 KRSF 425 >UniRef50_A8SU33 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=A8SU33_9FIRM Length = 448 Score = 406 bits (1044), Expect = e-111, Method: Composition-based stats. Identities = 112/432 (25%), Positives = 179/432 (41%), Gaps = 25/432 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 Y+E + LGL+ + + RLG + V +AGTNGKG+ C L+ I Sbjct: 1 MTYEEARKYIEYTDTLGSVLGLDSIKELLRRLGDPQNKVKVVHIAGTNGKGSICAFLDGI 60 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYF 124 L AGY VG Y SP + Y ER ++ G + E +++ + T F Sbjct: 61 LENAGYVVGRYISPTIFTYLERFQINGTYMDEDTFAVYLERVKNVADAMAADGLNRPTSF 120 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRES 183 E T A F +D+++LE G+GG LDATN+ ++ SI++DHT +LG + Sbjct: 121 ETETAIAFCYFMDKNVDILLLETGMGGLLDATNVCKSPLCTIIASISMDHTQFLGDTLQK 180 Query: 184 IGREKAGIFRSEKPAI---VGEPEMPSTIA--DVAQEKGALLQRRGVEWNYSVTDHDWAF 238 I +K GI + + P + V E MP I D G + + + D + Sbjct: 181 IYSQKLGIMKKDVPCVAYPVNEDLMPQWIEKCDENATTGFSVMVNPSDIGILHSGLDGSS 240 Query: 239 SDAHGTLENLPLPL-VPQPNAATALAA---LRASGLEVSENAIRDGIASAILPGRFQIVS 294 G +L +P N+ A+ L+ G ++ I DG+A+ GRFQ + Sbjct: 241 YIYKGNTYDLAVPGIYQIYNSVVAVETAYMLQKEGYDLKNVNISDGLAATRWKGRFQKLM 300 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 + P V D AHNP L + ++ + G+ DKD L + + Sbjct: 301 DVPPVYVDGAHNPGGWRALRKNIDTYFPGRDLIYICGVFRDKDYRQMLEIMMPGAGSFIA 360 Query: 355 APLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAK--AEDTVLVCGSFHTVA 408 + PR + +L E + D V A + A+ + + V++ GS + Sbjct: 361 VQPDNPRALSNRELGELAKMYIDSVYVQDDVDDAVEQALRISSEVEDPVVIIFGSLSFIG 420 Query: 409 HVMEVIDARRSG 420 +ID G Sbjct: 421 ---PIIDRAEHG 429 >UniRef50_B3E778 FolC bifunctional protein n=3 Tax=Desulfuromonadales RepID=B3E778_GEOLS Length = 428 Score = 405 bits (1043), Expect = e-111, Method: Composition-based stats. Identities = 128/417 (30%), Positives = 193/417 (46%), Gaps = 18/417 (4%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 + LS L I GLER++ + R G + + V GTNGKG+T L +I+ Sbjct: 4 SQQLSRLFGRRRFNIKPGLERITALLERHGHPERSFAAIHVVGTNGKGSTAAFLAAIIEQ 63 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALW 133 AGY G+++SPHLV YTER RV G + P A ++ G T+FE T A Sbjct: 64 AGYCTGLFTSPHLVSYTERFRVNGVDCPPEQLEALIPDLLEQAGPDD-TFFELTTALACH 122 Query: 134 LFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFR 193 F + ++ + +LE G+GGR DAT V +++ IALDH WLG D +SI EK I R Sbjct: 123 WFARNKVQLAVLEAGMGGRSDATAAVAGIATIISPIALDHCQWLGNDLQSIAAEKVAIAR 182 Query: 194 SEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD--WAFSDAHGTLENLP 249 P I P++ + I + + L G ++N + D F+ + G+L L Sbjct: 183 PGSPVISAVQPPDVQAVIEEYCRTNNNRLLLAGRDFNATSNGADTGLTFTGSSGSLSGLH 242 Query: 250 LPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVS--ESPRVIF 301 L A L G +S+ A++ G+A+A PGR + + + ++ Sbjct: 243 PSLSGSYQTGNAALALAAAEQLATLGFPISQQAMQAGLATARWPGRLERLRLADGSELLL 302 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D AHNP A+ L ++ L K R++ ++GM+ DKD+ G L L V R Sbjct: 303 DGAHNPAGAQALAAALQELGK-RRIILLLGMMEDKDLQGVLQPLLQRVQQVITVSPAQER 361 Query: 362 GATAEQLLEHLGN----GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 A +L + DSVA +AA A A D ++ GS V + ++ Sbjct: 362 ALPATELAARCRTAGTPATAADSVAAGLEAARAAAGPGDLIVAAGSLFLVGELKALL 418 >UniRef50_Q97AP2 Folylpolyglutamate synthase n=2 Tax=Thermoplasma volcanium RepID=Q97AP2_THEVO Length = 407 Score = 405 bits (1042), Expect = e-111, Method: Composition-based stats. Identities = 120/408 (29%), Positives = 187/408 (45%), Gaps = 25/408 (6%) Query: 35 VSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVR 94 + A LG + + G+NGKG+T + SIL + VGVY+SPHL R+ ER+ Sbjct: 2 MREFADMLGHPERDFRSIHITGSNGKGSTSAFIYSILRQK-FSVGVYTSPHLERFNERII 60 Query: 95 VQGQELPESAHTASFAEIESARGDIS-----LTYFEYGTLSALWLFKQAQLDVVILEVGL 149 V +E+P+ + ++S T+FE T+ A FK ++D +EVGL Sbjct: 61 VDNEEVPDEYIDGFIEKYRPKFDELSKVNRNPTFFEVTTMMAFQYFKDRKVDYASVEVGL 120 Query: 150 GGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGE--PEMPS 207 GGRLDATNI+ +V+V+ + +H D LG SI EKAGI + +P ++ + PE+ + Sbjct: 121 GGRLDATNIIMPEVSVIAQVGYEHADKLGCSLTSIAYEKAGIIKEGRPIVLQDDKPEVVN 180 Query: 208 TIADVAQEKGALLQRRGV----EWNYSVTDHDWAFSDAHGTL--ENLPLPLVPQPNAATA 261 + +AQ K + L + D+ F + T + NAATA Sbjct: 181 EVRRIAQVKHSPLITLDRNKIKNLHVDENGTDFDFDGTNDTYHIHTSLIGDYQALNAATA 240 Query: 262 LAALRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALP 321 + A+ S ++V + I GI+ I PGR +I+ SP VI D AHNP AA + +K + Sbjct: 241 ILAVENSKVQVYKKDIETGISRTIWPGRLEIIDRSPLVIIDAAHNPPAANKMVRTVKKVF 300 Query: 322 KNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-PRGATAEQLLE----HLGNGK 376 N V G+L DKD + L+ + E R L+ + + Sbjct: 301 -NREPTIVAGILSDKDAYSFFSVLRQLSGKIIFTTPEEKERAVDPNILMAQYGNLFRSAR 359 Query: 377 SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA--RRSGGK 422 A++ A +D V V GS + + + + D + G K Sbjct: 360 VIPDPISAFEHAKKV---DDFVFVTGSIYLIGVIRGLYDKANEKKGTK 404 >UniRef50_C7RCA3 FolC bifunctional protein n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RCA3_KANKD Length = 436 Score = 405 bits (1042), Expect = e-111, Method: Composition-based stats. Identities = 162/417 (38%), Positives = 235/417 (56%), Gaps = 14/417 (3%) Query: 9 AASPLASWLSYLENLHS-KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTL 67 + L W+++LE H I+LGL R+ VA LG+L+ V TVAGTNGKGT TL Sbjct: 6 DFNTLNEWIAWLEQAHPIHEIELGLSRIQKVANSLGLLELNAPVITVAGTNGKGTVVATL 65 Query: 68 ESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYG 127 ES+ + V Y+SPHL+ + ERV+ G + + +F I + DI LTYFE+ Sbjct: 66 ESLAVEHDLSVASYTSPHLLAFNERVKHNGYPVSDDLLITAFRHIAQHQSDIPLTYFEFT 125 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 TL A W+FKQ +LD+++LEVGLGGR+DA NI++ D+AV+TSI LDH DWLG E + E Sbjct: 126 TLVAFWIFKQQELDLIVLEVGLGGRMDAVNIINPDIAVITSIGLDHVDWLGDTLEKVAHE 185 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS----DAHG 243 KAGI RS+KP I+ + + S + + A +++ Y +WAFS Sbjct: 186 KAGIMRSDKPVIIADSQTQSLLLPEISARQAKGVVAQLDYQYEDRGSEWAFSSVNEGQEL 245 Query: 244 TLENLPLPLVPQPNAATALAA-LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVIFD 302 ++ L + N A+AL A L +V+ +I+ GRFQ +S++P VI D Sbjct: 246 SINGLANNDLLVSNLASALQAFLLVFPAKVNPESIKRAYEHLQFIGRFQYLSKAPIVIVD 305 Query: 303 VAHNPHAAEYLTGRMKALPKNG--RVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 VAHNP +A+ L +++ L + G + A+ GML DKDIAG+LA+ + +D W C L G Sbjct: 306 VAHNPDSAKILNQKLEQLKERGVEHITAICGMLKDKDIAGSLAY-CTAIDQWNCIDLPGQ 364 Query: 361 RGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 RG+ E+LL L + K++ + A D ++V GSF TVA ++E Sbjct: 365 RGSKGEELLNKLPEKSQKDAKTYHLLVDALDEYWQHQHQNQALVVFGSFVTVAMMLE 421 >UniRef50_B5ZCR5 FolC bifunctional protein n=2 Tax=Gluconacetobacter diazotrophicus PAl 5 RepID=B5ZCR5_GLUDA Length = 432 Score = 404 bits (1040), Expect = e-111, Method: Composition-based stats. Identities = 142/432 (32%), Positives = 198/432 (45%), Gaps = 25/432 (5%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCR 65 P+ + L L L+ IDL L R+ + ARLG + V VAGTNGKG+TC Sbjct: 8 PEFVGRAGAVLERLNRLYPALIDLSLGRLQALLARLGHPERHLPPVIHVAGTNGKGSTCA 67 Query: 66 TLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFE 125 TL +I AG+ V V +SPHLV TER RV G + A A EIE +T FE Sbjct: 68 TLRAIGEQAGWPVHVMTSPHLVDVTERFRVAGHIVSTDALVAVLEEIERVNDGAPITVFE 127 Query: 126 YGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESI 184 T + LF + + I+EVGLGGR DATN+++ +TSI++DH +LG +I Sbjct: 128 VLTAAGFLLFARHPARLAIIEVGLGGRFDATNVLEKPAACAITSISMDHEAFLGDSLAAI 187 Query: 185 GREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAH 242 EKAGI + P + G + + A + GA L+ RG +W+ + T ++DA Sbjct: 188 AAEKAGIMKPGVPVVTGRQAEAAMAVLRAQAAQCGAPLRVRGEDWDIAATPGGLRYTDAR 247 Query: 243 GTLENLPLPL----VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSE--- 295 G L +LPLP NA A+AALRASGLEV ++A GIA + P R Q + Sbjct: 248 GAL-DLPLPGLPGAHQIDNAGLAVAALRASGLEVPDSAW-AGIAHTVWPARMQRLGGALA 305 Query: 296 -----SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 + D HNP A + L + + V V+GM KD AG L+ + Sbjct: 306 GLLPPEWELWLDGGHNPGAGQALADVLAGW-SDRPVHLVVGMKQTKDAAGFLSPMLPHAA 364 Query: 351 DWYCA-PLEGPRGATAEQ-LLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVA 408 E + G ++ A V++CGS + Sbjct: 365 SVQAVAEAGQHLALPVEAIIAASSGRATPGPTLRAALGR---LTGEPARVVICGSLYLAG 421 Query: 409 HVMEVIDARRSG 420 +E D R+G Sbjct: 422 VALEQ-DGWRAG 432 >UniRef50_B1H0E2 Folylpolyglutamate synthetase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1H0E2_UNCTG Length = 421 Score = 404 bits (1039), Expect = e-111, Method: Composition-based stats. Identities = 104/412 (25%), Positives = 177/412 (42%), Gaps = 22/412 (5%) Query: 25 SKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSP 84 + + GL R+ + + +AGTNGKG+T + IL A GYK +YSSP Sbjct: 9 YEGMTPGLSRIKKFFKSIDNPQNKLKAVHIAGTNGKGSTAAFISEILKAGGYKTALYSSP 68 Query: 85 HLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVI 144 HL+ TER+++ G+ +P + L+YFEY T A F + + D+ + Sbjct: 69 HLIDITERIKIDGENIPSKIFNGLSKKYLERAVKYKLSYFEYLTALAFIYFAEQKTDIAV 128 Query: 145 LEVGLGGRLDATNIV-DADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEP 203 +E GLGGR DATN++ + +TSIA +H + LG + E I EKAGI + + + G+ Sbjct: 129 IETGLGGRFDATNVIKKPLICAITSIAKEHQEILGAETEKIAFEKAGIIKGDAYVVCGK- 187 Query: 204 EMPSTIADVAQEKGALLQRRGVEWNY-----SVTDHDWAFSDAHGTLENLPLPLVPQPNA 258 +P V + K G + S + + ++ + L+N+ + L+ + A Sbjct: 188 -LPKRAITVIKNKSNPYYLYGKDLKVANNKSSRSRQKFDYTSKNAELKNIEIGLLGRHQA 246 Query: 259 ATALAA------LRASGLEVSENAIRDGIASAILPGRFQIVS-----ESPRVIFDVAHNP 307 A A L G +SE IR G+ +A+ GRF I ++ +I D AHN Sbjct: 247 VNASIAIFAAGLLNKKGYYLSEAHIRTGLKNAVWQGRFDIRKIHSNNKNFELIIDGAHNI 306 Query: 308 HAAEYLTGRMKAL-PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 + L + + + ++ +K + S + R E Sbjct: 307 QGLNAFFETFEQLGFSKKKRIFIFTVMKEKKYKYMVKKTASFAKKVILPRINNDRALNPE 366 Query: 367 QLLEHLGNGKSFDSVAQA--WDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 L + + + + A A A +T + GS + V +++ I+ Sbjct: 367 VLKKEFSKYIAQNKICTADSVKNACAMISDNETSVAVGSLYLVGEILKYINE 418 >UniRef50_UPI0001C34EE0 FolC bifunctional protein n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001C34EE0 Length = 456 Score = 404 bits (1039), Expect = e-111, Method: Composition-based stats. Identities = 116/432 (26%), Positives = 180/432 (41%), Gaps = 27/432 (6%) Query: 15 SWLSYLENLHSKTI-DLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 YL+ + + L+ + + +G+ + VAGTNGKG+ C L SIL Sbjct: 28 EAEQYLDGIPKFSREKHSLDDIRAMMKAMGLSLDKIRLIHVAGTNGKGSVCAFLSSILRE 87 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTYFEYG 127 AG V++SPHLV ER G++ E +F + + G TYFE+ Sbjct: 88 AGEHTAVFTSPHLVSVRERFCFDGEQAGEKEFLQAFYRVREGLCRLQSLGLTHPTYFEFL 147 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGR 186 L + + + ++E GLGGRLDATN VD + V+TSI+LDH ++LG E I Sbjct: 148 FLMFAAMMQSRKGFTAVVETGLGGRLDATNAVDRPTLCVLTSISLDHMEYLGNTVELIAG 207 Query: 187 EKAGIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 EKAGI + P + +P + I D A+E + + G + D Sbjct: 208 EKAGIIKPGVPVVYDSTDPAAAAVIRDRARELKSPARAVGTDSFSESVLKDGHLFIRKNG 267 Query: 245 LENLPLPLVPQPNAATALAALRASGLE-VSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 E L +P Q A A+ A++A+ + + E A+R+G+ + PGR + + P V D Sbjct: 268 EEPLEIPFAAQYQAVNAMLAVQAAEILGIPERAVREGLQKTVWPGRMEEIM--PGVYLDG 325 Query: 304 AHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV--DDWYCAPLEGPR 361 AHN +L R + + + DK+ L D + R Sbjct: 326 AHNEGGIRAFARAAASL-SGKRKILLFAVSSDKEYREMAEILLREFAPDVLILTQIAYGR 384 Query: 362 GATAEQLLEHLGNGK-----------SFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHV 410 G +L E S +A A+ + EDTV GS + + + Sbjct: 385 GLDIHRLEEASREAMAKAGGHGPRLFVRPSAEEALLTALDEKGEEDTVFCAGSLYLIGEM 444 Query: 411 MEVIDARRSGGK 422 +VI G + Sbjct: 445 KDVIRRNHYGER 456 >UniRef50_A1ZCQ8 Folylpolyglutamate synthase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZCQ8_9SPHI Length = 428 Score = 404 bits (1039), Expect = e-111, Method: Composition-based stats. Identities = 118/426 (27%), Positives = 189/426 (44%), Gaps = 22/426 (5%) Query: 5 RTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTC 64 Q L L +N+ K + L+ + A LG +AGTNGKG++ Sbjct: 2 TYEQTLDYLYKQLPIFQNIGGKAFNASLDNIRRFCAHLGNPHTQYPTLHIAGTNGKGSSS 61 Query: 65 RTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYF 124 L ++L AAGYKVG+Y+SPHL +TERVRV GQ + + A ++ ++F Sbjct: 62 HMLAAVLQAAGYKVGLYTSPHLKSFTERVRVNGQAIAPAQIVAFVQRYQTQIESWRPSFF 121 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESI 184 E AL F Q ++DV ++EVGLGGRLDATNIV + ++T+I+ DH LG ++I Sbjct: 122 EVTVAMALDYFAQQKVDVAVIEVGLGGRLDATNIVTPEACLITNISFDHQQILGNTLKAI 181 Query: 185 GREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD----WAF 238 +EKAGI + P ++G + E +Q+ A L E+ D Sbjct: 182 AKEKAGIIKLNTPVVIGERQTETTPVFETTSQQHQAPLYFAQDEYFCKWADVAQGKLMVK 241 Query: 239 SDAHGTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIAS----AILPG 288 + L + + L L L+ ++++ I +G+ L G Sbjct: 242 KNGKAFLPEITMSLKGSYQEKNINGVLKVLEILQNRDWQITQEHIIEGLQKTVELTQLKG 301 Query: 289 RFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSV 348 R+Q++ ++P I D AHN + ++ V+G + DK + L L + Sbjct: 302 RWQVLKKAPLTICDTAHNEAGLSQVM-TQLQQLPRQQLHIVLGAMADKVLDKIL-PLFPM 359 Query: 349 VDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGSF 404 +Y PR +L + G ++ SV +A+ A + A+ D V GS Sbjct: 360 EATYYFCAPAIPRAMEVNKLKQLAAGFELRGLAYASVMEAYTQAQSQAQINDVVFAGGST 419 Query: 405 HTVAHV 410 +A + Sbjct: 420 FVLAEI 425 >UniRef50_C1CYP7 Putative tetrahydrofolate synthase (Folylpolyglutamate synthase) n=2 Tax=Bacteria RepID=C1CYP7_DEIDV Length = 435 Score = 404 bits (1038), Expect = e-111, Method: Composition-based stats. Identities = 135/422 (31%), Positives = 196/422 (46%), Gaps = 15/422 (3%) Query: 1 MIIKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 M ++ A L + L +L + + GL RV + RLG + A V V GTNGK Sbjct: 9 MSLRGYA-ACVRLEADLEWLFSRQRFGMHPGLTRVHSLLTRLGEPQRAFRVVLVGGTNGK 67 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 G+T +L S+L A G +VG+++SPHL R+ ER V G+ LP+ S ++ I Sbjct: 68 GSTAASLASMLRAQGRRVGLFTSPHLTRFAERFVVGGELLPDDVVLRSLHQVRPHAEAIE 127 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 ++FE T +F +A + ++EVGLGGRLDATN +D ++V+T++ALDHT+ LG Sbjct: 128 ASFFEIVTALGCLVFAEAGVQDAVMEVGLGGRLDATNALDPVLSVITNVALDHTEVLGNT 187 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRG---VEWNYSVTDHDWA 237 E I EKAGI R +PA+ G P + + +GA L + Sbjct: 188 VELIAAEKAGILRPGRPAVTGA--APDV-WPMLEAEGADLWSLENRVRRQSLGWDGEQVV 244 Query: 238 FSDAHGTLENLPLPLVPQPNAATALAALRAS-GLEVSENAIRDGIASAILPGRFQIVS-E 295 G PL+ A A A A+ L VS AI G + PGR ++++ Sbjct: 245 VRLPAGVELTFRTPLLGAHGAQNAALAAAAAYRLGVSPEAISRGAQTTQWPGRMEVLTVG 304 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCA 355 RV+ D AHNP AE + ++ L G++ V G DKD++G A L+ V Sbjct: 305 EGRVLLDGAHNPAGAEAVVRALRDL-GVGKLPLVFGAAADKDLSGVAAALEPVASQVVLT 363 Query: 356 PLE-GPRGATAEQLLEHLG--NGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 PR A L +S QA A A LVCGS + + V Sbjct: 364 RARLSPRSADPAALAPLFPGHQVTLTESPEQAIAALRALGAP--LALVCGSLYLIGEVRP 421 Query: 413 VI 414 ++ Sbjct: 422 LL 423 >UniRef50_B3PFP2 Folylpolyglutamate synthetase n=1 Tax=Cellvibrio japonicus Ueda107 RepID=B3PFP2_CELJU Length = 430 Score = 404 bits (1038), Expect = e-111, Method: Composition-based stats. Identities = 177/420 (42%), Positives = 251/420 (59%), Gaps = 16/420 (3%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 LA+WL +LEN H + IDLGLER+ LVA R+G+L+P V TV GTNGKG+ + Sbjct: 3 FDSLAAWLEWLENCHPREIDLGLERIRLVAGRMGLLQPTARVVTVGGTNGKGSCVTATAA 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTY 123 +L AAGY VGVY+SPHL Y ERV + G+ + + A SF I + ISLTY Sbjct: 63 LLRAAGYSVGVYTSPHLRVYNERVTIDGEPVDDQALCNSFERIYACCHANPPAEPISLTY 122 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FEYGTL+AL +F+ +D ++LEVGLGGRLDA NI+DAD++V+TSI +DH DWLG +RE Sbjct: 123 FEYGTLAALDIFRARSVDAMVLEVGLGGRLDAVNILDADISVITSIDIDHKDWLGDNRED 182 Query: 184 IGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-HDWAFSDAH 242 IG EKAGI+R+ +PAI + + P + + GA RG ++Y D + W +S + Sbjct: 183 IGFEKAGIYRAGRPAICADFDPPQRLLQAIIDLGAKGYLRGKHFDYHQEDTNHWRWSGSA 242 Query: 243 GTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVS-ESPRVIF 301 G E+ PLP +P P+ A AL A+ G+ V+ + +A +PGRFQ ++ + VI Sbjct: 243 GHFEHQPLPQLPLPSMAAALEAVTHLGVTVTPASFAL-LAELRVPGRFQHLAWQGRTVIL 301 Query: 302 DVAHNPHAAEYLTGRMKALP---KNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLE 358 DVAHNP A +L + RV A + M+ DKD G+LA L++++D W L+ Sbjct: 302 DVAHNPAATLHLAKGLSDWRNTNPGARVFAAVAMMSDKDRPGSLANLQALMDGWLLVDLD 361 Query: 359 GPRGATAEQLLEHLGNGKSFD----SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 PR A++EQL ++L + + A + + D ++V GSF TVA +EV+ Sbjct: 362 IPRAASSEQLRKNLQDLGFEPLASGKMKACLQALLQVSVQGDLLVVFGSFFTVAAALEVL 421 >UniRef50_B1ZVD5 FolC bifunctional protein n=4 Tax=Verrucomicrobia RepID=B1ZVD5_OPITP Length = 440 Score = 403 bits (1037), Expect = e-111, Method: Composition-based stats. Identities = 133/431 (30%), Positives = 201/431 (46%), Gaps = 31/431 (7%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 P AA+ + YL L + LGL+R+ L+AA LG + A VAGTNGKG+ Sbjct: 15 PDAAAGFEAVAEYLCGLKAGGSKLGLDRMRLLAAELGHPERALRCVHVAGTNGKGSVAAM 74 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE------SARGDI- 119 LE+IL AAG++VG+++SPHLV ERV+V Q L + E++ +AR Sbjct: 75 LEAILRAAGWRVGLFTSPHLVHVGERVQVNRQPLAPAEIVGYVRELDVLADRIAAREGPG 134 Query: 120 -SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLG 178 ++FEY T AL F + + D+ ++EVGLGG DATN+VD ++ V+TSI DH +WLG Sbjct: 135 DRPSFFEYMTAMALLQFGRQRCDIAVMEVGLGGEFDATNLVDPEMTVITSIGFDHCEWLG 194 Query: 179 PDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDW 236 E I R KAGI + E+P ++G P + I A+E A + + Sbjct: 195 HTLEEIARAKAGIIKPERPVVIGRVPPAAETVIRARAEEMEARVISVREVYG-------- 246 Query: 237 AFSDAHGTLENLPLPLVPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQ-IV 293 + E + NAATA A R +SE AI G+ PGR+Q ++ Sbjct: 247 --ENLAVYPETNLAGDYQRWNAATATLAARELDSRWRISERAIAHGLWHVRWPGRWQRVL 304 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKAL--PKNGRVLAVIGMLHDKDIAGTLAWLKSVVDD 351 RVI D +HN A L + L + V+G+L + +A + + Sbjct: 305 VGGRRVILDASHNAEGASVLDANLARLRAETGRAPIVVVGVLGAERAQPLMAAICRHAGE 364 Query: 352 WYCAPLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAA------MADAKAEDTVLVCGSFH 405 + PR ++ E+L + G A +D++++ GS + Sbjct: 365 VHLVVPNQPRASSYEELAALIPAGFPGRVARTTVAEIFPGGDHCALGGPDDSIVITGSIY 424 Query: 406 TVAHVMEVIDA 416 + V+ I A Sbjct: 425 LLGEVLPRIGA 435 >UniRef50_A5Z386 Putative uncharacterized protein n=1 Tax=Eubacterium ventriosum ATCC 27560 RepID=A5Z386_9FIRM Length = 462 Score = 403 bits (1036), Expect = e-111, Method: Composition-based stats. Identities = 115/453 (25%), Positives = 189/453 (41%), Gaps = 50/453 (11%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + YL+N++ LGL + + RLG + V +AGTNGKG+ +++ILM Sbjct: 5 YSEAREYLKNVNKLGSILGLNTIKELLKRLGNPQNELKVVHIAGTNGKGSIMTFVQNILM 64 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA------RGDISLTYFEY 126 +GYKVG Y SP + E +R+ + + E I+ G T FE Sbjct: 65 ESGYKVGRYCSPAVFNEREIIRINDEYISEEQSADLLTRIKEKCDSMYSEGLPHPTSFEI 124 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADV-AVVTSIALDHTDWLGPDRESIG 185 T AL FK+ D+ ++E G+GG DATN+ + + +V+ +I+LDHT +LG E I Sbjct: 125 ETAEALMFFKEQNCDIALIECGMGGETDATNVFEKVLCSVIATISLDHTQFLGSTIEEIT 184 Query: 186 REKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS---- 239 + K+GI + P ++ + E + I V ++ + L + +V Sbjct: 185 KVKSGIIKENCPVVMSKQTVEAENVIKKVCKQNNSKLIIPTEQDFENVEIDGLTTKVTYK 244 Query: 240 ---DAHGTLENLPLPLVPQPNAATALAALRASGLEVS----------------------- 273 + L L NA TA+ ++ Sbjct: 245 ASNNKEYILNLQALGTYQIKNAKTAVEVALVLDKALTEKTNICDESDKKNGTGMKNNINN 304 Query: 274 -----ENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLA 328 E I+ GI + PGR +++S+ P +I D AHNP A L + N R+ Sbjct: 305 SGNTIEKNIKKGIEKTVWPGRMEVISKEPLIIIDGAHNPGAVLELRKTLDLYFTNKRITF 364 Query: 329 VIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHL----GNGKSFDSVAQA 384 ++G+L DKD + + + RG +L E L N + DS+ QA Sbjct: 365 IMGVLSDKDFSKEAEIIADRAERIITITPNNSRGLDGHKLAETLVKYNHNVQVADSLKQA 424 Query: 385 WDAAMADAKAE--DTVLVCGSFHTVAHVMEVID 415 + ++ K D +L GS + + +V+ Sbjct: 425 AEESIDTIKENRADMILAFGSLSYLGELKQVVR 457 >UniRef50_Q6KZL1 Folylpolyglutamate synthase/dihydrofolate synthase n=3 Tax=Thermoplasmatales RepID=Q6KZL1_PICTO Length = 435 Score = 402 bits (1035), Expect = e-110, Method: Composition-based stats. Identities = 120/420 (28%), Positives = 194/420 (46%), Gaps = 26/420 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + + L+YL L + I LGL+ A LG + +AGTNGKG+ + +IL Sbjct: 1 MDNILNYLYELKREGIKLGLDTTRAFAEHLGNPQDKYKKIHIAGTNGKGSISSYIYNILR 60 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-----LTYFEYG 127 Y G+Y+SPHL+++ ER+ + + + +E +S T+FE Sbjct: 61 QR-YNTGLYTSPHLIKFNERIIFNKEMISDDYIINFISENRDYIDKLSKIKMNPTFFETT 119 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T+ A F D +EVGLGGRLD+TNI+ +++++ I +H LG SI E Sbjct: 120 TVMAFKYFYDMHADYAAIEVGLGGRLDSTNIIIPEISIIGQIGYEHYQKLGCSLTSIAYE 179 Query: 188 KAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFS------ 239 K GI + P ++ + PE+ + I ++Q + + L +++ S + F Sbjct: 180 KGGIIKPGIPVVLQDKKPEVLAEIKKLSQVRKSKL-ILSEDYSKSTEPELYNFKMVFDLK 238 Query: 240 --DAHGTLENLPLPLVPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 +E+ L L N TA+AAL ++++ + GI AI GR +I+ SP Sbjct: 239 TPLNEYHIESNNLGLYQVKNIKTAVAALENMDTSINKHDVESGIDKAIWHGRMEIIRASP 298 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 VI D AHNP AA L K K +L + GML DKD+ L ++ + D Sbjct: 299 LVIIDSAHNPPAASNLVPSFKKFIKKKPLLLI-GMLSDKDVFSFLTIMRQLSDKIVLTMP 357 Query: 358 EGP-RGATAEQLLEHL----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 P R + + + + K A+D ++ ++ D VLVCGS + + +M Sbjct: 358 NEPDRALDPDNIKDIASSIYRDVKIIKDPLSAYDYSLKNS---DCVLVCGSMYLIGDIMS 414 >UniRef50_C7RHW8 FolC bifunctional protein n=3 Tax=Anaerococcus RepID=C7RHW8_ANAPD Length = 425 Score = 402 bits (1034), Expect = e-110, Method: Composition-based stats. Identities = 94/421 (22%), Positives = 183/421 (43%), Gaps = 20/421 (4%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + ++ N S + LE++ + + V +AGTNGKG+T + + Sbjct: 1 MENFNQYYEFILNRGSTSGGHSLEKIKNLLEYFDNPQDKIKVIHIAGTNGKGSTANMIAN 60 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-----SLTYF 124 L +VG+++SP++ + E + + G ++ +S ++ ++ +YF Sbjct: 61 TLSREN-RVGLFTSPYMTKINEAISISGVDISDSDFAEIIDRLKKPLEELDKKGLHNSYF 119 Query: 125 EYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRES 183 E T F + ++DV ++EVGLGG LD+TNI+ V+T+I+ DH LG E Sbjct: 120 EVLTAIMYIYFYEKKVDVAVVEVGLGGSLDSTNIIKSPLACVITTISKDHIQILGDSLEE 179 Query: 184 IGREKAGIFRSEKPAIVGEPE--MPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 I + KAGI + + + E + + + L E + + Sbjct: 180 IAQNKAGIIKDKSEVFLYPKEGTVKEVFIKKIENTSSRLHTFDKEEINIIKTGPDYNEFS 239 Query: 242 HGTLENLPLPLVPQPNAATALAALRASG-----LEVSENAIRDGIASAILPGRFQIVSES 296 + +N+ LV A+ AL + E I +G+ + PGR ++++++ Sbjct: 240 FRSYKNIKTRLVGIHQIYNAVTALITLDFLKDEFSICERDIYEGLLTTRNPGRLELINKN 299 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 PRV+ D +HN A + L + + K +++ +L DKD + L + D+ Sbjct: 300 PRVLVDGSHNREAIDALIDSI-SSYKYRKLIVGFSILKDKDYDYVIDSLAKIADEIIVTK 358 Query: 357 L-EGPRGATAEQL----LEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVM 411 + + PR ++L + + +A++ + A +D VL CGS + V ++ Sbjct: 359 IKDNPRAFDTDELYSLVKDKAKKAIEIVDLVKAYEYSKELAHEDDLVLWCGSLYLVGDIL 418 Query: 412 E 412 + Sbjct: 419 K 419 >UniRef50_D0KZW9 FolC bifunctional protein n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0KZW9_HALNC Length = 429 Score = 402 bits (1034), Expect = e-110, Method: Composition-based stats. Identities = 150/422 (35%), Positives = 227/422 (53%), Gaps = 11/422 (2%) Query: 3 IKRTPQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA--PFVFTVAGTNGK 60 + P + LA WL +LE + IDLGL+RV+ V +L P V TVAGTNGK Sbjct: 1 MSHAPAEQAALAEWLLWLEARNPARIDLGLDRVADVWRKLKQEGNLVVPKVITVAGTNGK 60 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS 120 G++ LE+IL+A GY+VG Y+SPH+ R+ ER+R+ G ++ + + ++ + G + Sbjct: 61 GSSVALLEAILLAEGYRVGAYTSPHIERFNERIRLMGADIQDHELVVAMCQLAATDGSEA 120 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 LTY+E+ TL+A F +A LD+ ILEVGLGGRLDA NI+DAD+A++T+I LDH +LG Sbjct: 121 LTYYEWATLAAFLAFCRANLDIWILEVGLGGRLDAVNILDADLALITNIGLDHQAYLGDT 180 Query: 181 RESIGREKAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF-S 239 R IG EKAG+ R + A+ + + ++ D A G L RG ++ W Sbjct: 181 RTQIGYEKAGVLRKGQAAVYADTDPIESVIDHANAIGCPLIVRGRDFMVEADATGWRLEQ 240 Query: 240 DAHGTLENLPLPLVPQPNAATALAALRASG-----LEVSENAIRDGIASAILPGRFQ-IV 293 + LP + + A + + L + ++I G+ SA GRF+ V Sbjct: 241 GDRSSYWPLP-GMFGRTQVDNAASVVALLQHPKSTLNLRASSIEAGVRSAKNRGRFEIWV 299 Query: 294 SESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY 353 E +VI DVAHN + L + AL R LAV G L DK I ++ + D+WY Sbjct: 300 HEGRQVILDVAHNLESVRVLLDNLHALATPSRRLAVFGALDDKPIEAMISLCRPEFDEWY 359 Query: 354 CAPLEGPRGATAEQLLEHLGNGKSFD-SVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 L+ R A+ +L L + + S+ A++AA A + D ++ GSF+TV+ + Sbjct: 360 LGQLDSVRSASIARLSSALDRPQISETSITSAYNAAFAHSAVGDQIIAFGSFYTVSAIRH 419 Query: 413 VI 414 V+ Sbjct: 420 VL 421 >UniRef50_D1BZM6 FolC bifunctional protein n=10 Tax=Actinomycetales RepID=D1BZM6_XYLCX Length = 468 Score = 402 bits (1034), Expect = e-110, Method: Composition-based stats. Identities = 128/415 (30%), Positives = 194/415 (46%), Gaps = 30/415 (7%) Query: 12 PLASWLSYLENLHSKT-IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L + + + ID L+RV V LG + V + GTNGK +T R +ES+ Sbjct: 25 SLREVYREIMSRAPEHDIDPTLDRVRRVLELLGDPQRTYRVVHLTGTNGKTSTARMVESL 84 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES----------ARGDIS 120 + G + G+++SPHL TER++V G L + + ++ G Sbjct: 85 VREHGLRTGLFTSPHLTSVTERIQVDGAPLSAARFVEVWEDVAPYIGVADRESAESGGPR 144 Query: 121 LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPD 180 L++FE T+ AL F A +DV ++EVG+GG D+TN+ D DVAVVT + +DH WLG Sbjct: 145 LSFFEVLTVMALAAFADAPVDVAVIEVGMGGTWDSTNVADGDVAVVTPVGMDHQRWLGDT 204 Query: 181 RESIGREKAGIFRSEKPAI--VGEPEMPSTIADVAQEKGALLQRRGVEW-----NYSVTD 233 E+I K+GI + A+ V EP + + A+ GA L R G E +V Sbjct: 205 LEAIASTKSGIVKDGATAVMSVQEPVVSDVVRARAEAVGAHLLREGYELEVAGRQVAVGG 264 Query: 234 HDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS------GLEVSENAIRDGIASAILP 287 G + +PL + A AL AL A G + + G A + P Sbjct: 265 QVVDLRTPAGLYTGVLVPLHGEHQAHNALLALAAVEALLSGGGALDAGVVEAGFAGVVAP 324 Query: 288 GRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKS 347 GR ++V SP V+ DVAHNPH A+ L + + + R++ V+G++ DKD G LA L+ Sbjct: 325 GRVEVVRSSPTVLVDVAHNPHGAQALVDTLDEVFEFTRLVGVVGIMGDKDAEGLLATLEP 384 Query: 348 VVDDWYCAPLEGPRGATAEQLLEHLGN------GKSFDSVAQAWDAAMADAKAED 396 V+ + R A L E + +S+A+A A A+ +D Sbjct: 385 VLAEVVLTRNSSDRSADPLDLREIAEDVFGEDRVHVVESLAEALQVAADLAERDD 439 >UniRef50_C0D144 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0D144_9CLOT Length = 432 Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 109/432 (25%), Positives = 177/432 (40%), Gaps = 34/432 (7%) Query: 15 SWLSYLENLH-SKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 + YL + LE V +G A VAGTNGKG+ C L L Sbjct: 3 NAEEYLLEIPMWTKQKNSLEDVRAYLEAMGNPDRALKAVHVAGTNGKGSVCAFLTCALKE 62 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI------SLTYFEYG 127 AG++ G + SPHL + ER + G+ + SF+ + + + T+FE+ Sbjct: 63 AGFRTGTFVSPHLEQVRERFLINGEMADRESFEQSFSTVLAVTERMVGQGKCHPTFFEFL 122 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGR 186 A+ LF++ Q+DV +LE G+GGRLD TN+++ V+TSI+LDHT +LG +I Sbjct: 123 FYMAMVLFREKQVDVAVLETGMGGRLDTTNVIESPLACVITSISLDHTQYLGDTISAIAA 182 Query: 187 EKAGIFRSEKPAIV--GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHD------WAF 238 EKAGI + P I G+PE + I A A G + D + Sbjct: 183 EKAGIIKERTPVIFDGGQPEASAVIEGRAYFLDAPRYPVGEDDFAIRGSLDGGTGFLMSA 242 Query: 239 SDAHGTLENLPLPLVPQPNAATALAALRAS------GLEVSENAIRDGIASAILPGRFQI 292 G + +P + A A+ A+R G+ V + A+R GI + PGR + Sbjct: 243 RMRDGRNLDFAVPFEARYQARNAMLAVRTLEILRGSGIAVDDRALRRGIRATRWPGRME- 301 Query: 293 VSESPRVIFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKSVV- 349 +P + D AHNP ++ + + + DKD + + Sbjct: 302 -QAAPGLYLDGAHNPGGIAAFQEAVRDVTGRTEKEPYLLFAAVADKDYRSMAEAICRGIP 360 Query: 350 -DDWYCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 A ++ RG +L + + ++ A M A + GS Sbjct: 361 WRGIGIARMKSSRGLDTAELAGVFRSFADCPVREYEDAETALAD-MRAAAEGQLLFCAGS 419 Query: 404 FHTVAHVMEVID 415 + + + E+++ Sbjct: 420 LYLIGELRELLN 431 >UniRef50_A3ZWP1 Folyl-polyglutamate synthetase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZWP1_9PLAN Length = 470 Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 129/447 (28%), Positives = 188/447 (42%), Gaps = 40/447 (8%) Query: 9 AASPLASWLSYLENL---------HSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNG 59 + +L ++ L R+ + LG L + +AGT G Sbjct: 18 EIRSYDEAIDFLLGRINYERAAVIPYRSPQFHLARMRRLDQLLGNLVDQLKIVHIAGTKG 77 Query: 60 KGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFA-------EI 112 KG+T TL +IL A GY+VG++SSPHL R ER + T +I Sbjct: 78 KGSTATTLSAILEADGYQVGLFSSPHLERLEERFAINRIACSADEVTQLIHDIAPVVLQI 137 Query: 113 ESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALD 172 ++ R TYFE T AL F + +D ILEVGLGGRLD+TNI V+V+T+I+ D Sbjct: 138 DAERDGDGPTYFEITTAMALMHFVRKGVDAAILEVGLGGRLDSTNICRPLVSVITTISRD 197 Query: 173 HTDWLGPDRESIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYS 230 H LG I EKAG+ ++E P I G +P+ + I +A + A L G ++ Sbjct: 198 HMALLGDTLAEIAAEKAGVIKTETPIISGVDQPDPTAVIEQIAAQHAAQLIEVGRDFVVQ 257 Query: 231 VTDHD-----WAFSDAHGTLENLPLPLVPQPNAATALAA------LRASGLEVSENAIRD 279 W + TL L + + A A L++ G VSE AIR Sbjct: 258 SHGERTFDLTWRQGEKSETLTGLMCRMAGKHQMRNAALAVMVAKSLQSYGFTVSEAAIRR 317 Query: 280 GIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIA 339 G++ A LPGR + +++SP + D AHN + L + LP N R V+ + DK+ Sbjct: 318 GVSDAELPGRIERLADSPVIYVDAAHNDASITALLDVLNELPVNRR-RLVLALSSDKEHR 376 Query: 340 GTLAWLKSVVDDWYCAP-LEGPRGATAEQLLEHLGNG---------KSFDSVAQAWDAAM 389 L L D+ + PR +L + QA+ AA+ Sbjct: 377 EILKLLLPHFDEIWFTRYATNPRAVEPAELEALAVKLPTGRRTVIRHIVEDPQQAFAAAI 436 Query: 390 ADAKAEDTVLVCGSFHTVAHVMEVIDA 416 A + D + V GSF Sbjct: 437 AASDENDLLCVAGSFFIAGEFRRFFRE 463 >UniRef50_B9ZQU2 FolC bifunctional protein n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZQU2_9GAMM Length = 443 Score = 400 bits (1030), Expect = e-110, Method: Composition-based stats. Identities = 168/416 (40%), Positives = 232/416 (55%), Gaps = 14/416 (3%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPA-PFVFTVAGTNGKGTTCRTLE 68 + LA WL++ E LH +DL LER++LVA RLG+ P P VAGTNGKGT Sbjct: 3 YATLAEWLAFQERLHPVGMDLTLERIALVADRLGLRGPGTPRTVMVAGTNGKGTVTTRTA 62 Query: 69 SILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGT 128 ++L A G KVG+++SPHL++Y ER+R+ G + +F I+ ARGD SLTYFE+ Sbjct: 63 ALLQAQGLKVGLFTSPHLLQYNERIRLNGMTASDEDLCRAFEAIDQARGDDSLTYFEFAA 122 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 L+A WLF++A++DV +LEVGLGGRLDA NI DADVA VT++ LDH WLG RE IGREK Sbjct: 123 LAAAWLFREARVDVQVLEVGLGGRLDAVNIWDADVAAVTAVDLDHQAWLGDSREVIGREK 182 Query: 189 AGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE-N 247 AGI R+ +P ++GE P ++ D A+ G R G +++ V + +E N Sbjct: 183 AGIMRAGRPVVLGELSPPQSVLDHARALGCRTVRLGRDFDLLVEQERLVWRWNGVQVEWN 242 Query: 248 LP----LPLVPQPNAATALAALRASGLE--VSENAIRDGIASAILPGRFQIVSESPRVIF 301 +P L N ATALA + + G+ +S + G+ PGR Q +S P + Sbjct: 243 VPLARGLSGAALANTATALAVVESLGMSAGLSAVTMEQGLK-VRPPGRLQRLSGPPEWLL 301 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 DVAHN A L ++ P G +A++ ++ DKD + L +VD W PL+ PR Sbjct: 302 DVAHNAQAVAELARWLRENPLVGPTVALVAVMADKDRSAMWRDLDGLVDIWIPVPLDLPR 361 Query: 362 GATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 A L L + + + QA A A + +V GSFHTVA V E Sbjct: 362 ALPAPDLAAELEQAGQADVRPAAGIRQALQQATDSAGIQGRCVVFGSFHTVAAVFE 417 >UniRef50_B2IS30 Dihydrofolate synthetase, putative n=37 Tax=Bacteria RepID=B2IS30_STRPS Length = 418 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 110/418 (26%), Positives = 178/418 (42%), Gaps = 21/418 (5%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 +L + GL R+ LG + + + V GTNGKG+T + + M Sbjct: 5 EVEEWLHSRIGLNFRSGLGRIQQAVDLLGNPEQSYPIIHVTGTNGKGSTIAFMRELFMGH 64 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-----DISLTYFEYGTL 129 G KV ++SPH+V +R+ + GQ + ++ +++ L++FE TL Sbjct: 65 GKKVATFTSPHIVSINDRICINGQPIADADFIRLADQVKEMEKTLLQTPDQLSFFELLTL 124 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 A F++ ++D+V+LEVG+GG LD TN+V ++AV+TSI LDH + LG E+I +KA Sbjct: 125 VAFLYFREQEVDLVLLEVGIGGLLDTTNVVTGELAVITSIGLDHQETLGDSLEAIAEQKA 184 Query: 190 GIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 GIF++ K A++ PE A+ L + G ++ D + + Sbjct: 185 GIFKAGKKAVIAKLPPEARLVCQKKAESLAVNLYQAGQDFLMLNGDFSSSLLNLSQLNIG 244 Query: 248 LPLPLVPQPNAATALAALRASGLE----VSENAIRDGIASAILPGRFQIVSESPRVIFDV 303 L + Q NAA AL E V E A+R + GR + + P++ D Sbjct: 245 LE-GVYQQENAALALQTFLLFMGEGKEAVDEQAVRKALEQTHWAGRLERIR--PQIYLDG 301 Query: 304 AHNPHAAEYLTGRMKALPKNG-RVLAVIGMLHDKDIAGTLAWLKSVVDDWY--CAPLEGP 360 AHN A L +K + G R + G L KD G L +L + + Sbjct: 302 AHNLPALTRLVEFIKEKEQEGYRPQILFGALKRKDYQGMLGYLTEKLPQVELKVTGFDYQ 361 Query: 361 RGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARR 418 + S + A A+D + V GS + ++ V + R Sbjct: 362 GALDERDV----TGYDIVSSYREFISDFEERADAQDLLFVTGSLYFISEVRGYLLDRE 415 >UniRef50_Q0BQJ2 Folylpolyglutamate synthase n=2 Tax=Acetobacteraceae RepID=Q0BQJ2_GRABC Length = 430 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 131/423 (30%), Positives = 204/423 (48%), Gaps = 27/423 (6%) Query: 14 ASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCRTLESILM 72 + + L LH K IDL L R+ + +LG + + V VAGTNGKG+TC L ++ Sbjct: 7 EAVIERLHGLHPKMIDLSLGRLEALLEKLGHPERSLPPVVHVAGTNGKGSTCAFLRALAE 66 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSAL 132 AAG +V VY SPHLV++ ER+R+ G+ + E + E+E +T FE T AL Sbjct: 67 AAGQRVHVYISPHLVQFNERIRLAGELVSEPVLVEALEEVERVNAGAPITVFEVITAVAL 126 Query: 133 WLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIF 192 LF + D+ ++EVGLGGR DATN+V V+ + SI++DH ++LG D I EKAGI Sbjct: 127 LLFSRVPADLCVVEVGLGGRFDATNVVTPVVSAIASISIDHREYLGDDIRGIAAEKAGIL 186 Query: 193 RSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPL 250 +S P + G P++ + A ++G L R +W+ + +SD G + +LPL Sbjct: 187 KSGAPGVTGLQLPDVLEVLDREAAKQGVSLLARDRDWHIARRGDGLRYSDPDGVV-DLPL 245 Query: 251 PLV-PQPNAATA------LAALRASGLEVSENAIRDGIASAILPGRFQI--------VSE 295 P + + A + A + L +S A +G+A A P R Q + + Sbjct: 246 PALPGEHQLDNAGIAVAAMRAAAKTALPLSWRA--EGLARAEWPARMQRLTGLLAKDLPD 303 Query: 296 SPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWY-C 354 + D HNP A L G ++ K+ ++GM KD LA + D + Sbjct: 304 GWELWLDGGHNPGAGVMLAGHLRGW-KDRPAHVIVGMKQAKDAGQFLASVLPEADTVWAI 362 Query: 355 APLEGPRGATAEQLLEHL-GNGKSFDSVAQAWDAAMADAKAE---DTVLVCGSFHTVAHV 410 A E ++ G +V QA A + A+A +L+CGS + + Sbjct: 363 AEPGQYLALPVEAIVSASGGKAIPGPTVRQAMAAILKQAEAGSIPGRILICGSLYLAGEI 422 Query: 411 MEV 413 +++ Sbjct: 423 LKL 425 >UniRef50_D0BMT5 Bifunctional protein FolC n=1 Tax=Granulicatella elegans ATCC 700633 RepID=D0BMT5_9LACT Length = 419 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 105/418 (25%), Positives = 188/418 (44%), Gaps = 17/418 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + + ++ + GL+R+ ++ + LG + + V GTNGKG+T L S+ + Sbjct: 1 MQTVREWILDRMKYKRKYGLDRMRVLMSLLGNPQEDYPIIHVTGTNGKGSTIAMLSSLFV 60 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFA-----EIESARGDISLTYFEYG 127 G KVG + SPHL+ YT+R + G +PE E++ L++FE Sbjct: 61 HHGQKVGAFVSPHLIDYTDRFLINGNVMPEEDFEIVGNLVQQAEVKLIDEYEPLSFFEIM 120 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T AL F + +++V +LEVG+GG LD TNIV + ++V+TSI +DH + LG E I + Sbjct: 121 TAMALVYFSRKKVEVALLEVGIGGLLDTTNIVHSTMSVITSIGMDHEEMLGNTLEEIAIQ 180 Query: 188 KAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA---- 241 K GIF+ + ++G E V + L E+N + + F+++ Sbjct: 181 KTGIFKPNQEVVLGKLPTEALQVAEVVGKAYNCDLHTFEREFNIEPFEDGFIFTNSDTRI 240 Query: 242 HGTLENLPLPLVPQPNAATALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSESP 297 H + NL NAA AL + L + +AI++ + PGR ++V +SP Sbjct: 241 HISYLNLK-GNYQLENAAVALECFLQFEKNFQLPIELSAIQESFQTVTWPGRMEVVHQSP 299 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPK-NGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 VI D AHN HA + +K + + + L K + +L+ + + Sbjct: 300 TVILDGAHNIHALKRFVETVKQHGELEAQHTILFSALKRKHYIEMVDYLRKELPEARLVV 359 Query: 357 LEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 E+ + ++ Q + + ++ + + GS + ++ V ++ Sbjct: 360 TTFEYAGAIEKTDYPSSEIEFVENAQQFIENYINKTSDQEILWITGSLYFISFVRKIF 417 >UniRef50_B0P9P5 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0P9P5_9FIRM Length = 400 Score = 399 bits (1027), Expect = e-110, Method: Composition-based stats. Identities = 120/402 (29%), Positives = 176/402 (43%), Gaps = 28/402 (6%) Query: 35 VSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVR 94 + + A LG + + +AGTNGKG+T +IL AAG + G+ SP + + ER++ Sbjct: 1 MRRLMALLGDPQERLRIVHIAGTNGKGSTAVMTAAILSAAGLRTGLTVSPFITDFCERIQ 60 Query: 95 VQGQELPESAHTASFAEIESARGDI-SLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRL 153 + G + A I + +T FE T +A F + V+ EVGLGGR Sbjct: 61 IDGAPIAHEALAREMTRIAPLAEQVGGMTEFELITAAAYSYFADSGCSAVVAEVGLGGRF 120 Query: 154 DATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIV---GEPEMPSTI 209 DATN++ V+V+T I LDHTD LG I EK GI + P + +P+ + I Sbjct: 121 DATNVISRPLVSVITRIGLDHTDVLGSTPGEIAFEKCGIIKPGVPVVTCGKQDPDALAVI 180 Query: 210 ADVAQEKGALLQRRG----VEWNYSVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAAL 265 + ++G L E + D+ + L LPL+ A+ A+ Sbjct: 181 MEECAKRGCTLISGNPGAVREVQSGLDGTDFIYQGM-----RLHLPLIGNHQITNAVTAI 235 Query: 266 RASGLEV--------SENAIRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRM 317 A+G + E I +A +P RF+IV +P VI D AHNP AA L + Sbjct: 236 TAAGQALPALLGRLPDERTIAKALAGVHVPARFEIVQRNPLVIIDGAHNPQAAGALADAL 295 Query: 318 KALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLG---- 373 L + V VIG+L DKD G L L + C E PR A +L Sbjct: 296 -TLLGDQPVTGVIGVLADKDSTGLLRALAPRLARVLCVTPESPRALGAHELAVRADAVGL 354 Query: 374 NGKSFDSVAQAWDAAMADAK-AEDTVLVCGSFHTVAHVMEVI 414 + S+ +A + A A A ++VCGS + V Sbjct: 355 RASAAHSIDEALELAQAVASAQGGAIVVCGSLLFASQVRARF 396 >UniRef50_A8SYS4 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=A8SYS4_9FIRM Length = 468 Score = 399 bits (1026), Expect = e-109, Method: Composition-based stats. Identities = 107/444 (24%), Positives = 190/444 (42%), Gaps = 39/444 (8%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + + Y+ + +G E +S + RLG + + VAGTNGKG+TCR L Sbjct: 25 VADYRETVDYILGIPLFAQKIGKENLSSLLCRLGNPEKSIPAVHVAGTNGKGSTCRALAQ 84 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 +L GY+VG++ SPHLV ER+++ G+ + ++ +F ++ ++FE Sbjct: 85 MLTGMGYRVGLFISPHLVSINERIQIDGENISDADFVWAFETVKEKFTQ-HPSFFEVMFA 143 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 A F++ + D V+ E G+GGRLDATN++ +++++TS+ +DH ++LG E I EKA Sbjct: 144 MAAVYFREKKCDFVVYETGMGGRLDATNVLMPELSIITSVGMDHMEYLGDTIEKIAAEKA 203 Query: 190 GIFRSEKPA--IVGEPEMPSTIADVAQEKGALLQRRGV-EWNYSVTDH---DWAFSDAHG 243 GI + P + + I D A+ + + + ++ + D++ + Sbjct: 204 GIIKPGIPIIYFKRDEAVAKVIEDTARGQKSPVIMVEKQDYIINHLGDKTIDFSLHSRYY 263 Query: 244 TLENL---PLPLVPQPNAATALAALRASG--LEVSENAIRDGIASA----ILPGRFQIVS 294 + NL L N + A+ A SE I GI GR + + Sbjct: 264 SYCNLVIQKTSLYQLENISLAVMAFYGLMKARNASEEDIEKGIRETLPEFYWEGRMEEI- 322 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVV--DDW 352 +P + D AHN A M+ L ++ R + V + DK+ ++ L S + D Sbjct: 323 -APHIYVDGAHNVEAIRAYIDTMRTLHRDDRKILVFAAVRDKEYGAMISMLASQLKWDRI 381 Query: 353 YCAPLEGPRGATAEQLLEHLGN-----GKSFDSVAQAWDAAMADAK-------------- 393 ++ R A + +L + + D + +A D A+A Sbjct: 382 IVTSVDSSRKADSGKLAQIFADNTDVPVLVSDEIDEAMDMAVALRTDIGTDLERCGGQGI 441 Query: 394 AEDTVLVCGSFHTVAHVMEVIDAR 417 + + GS + V V Sbjct: 442 DDVDIYCVGSLYLVGGVKRWRKKH 465 >UniRef50_B0T696 FolC bifunctional protein n=2 Tax=Alphaproteobacteria RepID=B0T696_CAUSK Length = 437 Score = 399 bits (1026), Expect = e-109, Method: Composition-based stats. Identities = 129/429 (30%), Positives = 196/429 (45%), Gaps = 26/429 (6%) Query: 8 QAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCRT 66 + L+ L+ LH K IDL L+R+ + LG + V VAGTNGKG+T Sbjct: 3 DHLRAHDAALARLQALHPKLIDLSLDRMRRLCTALGEPQKRLPPVIHVAGTNGKGSTVAY 62 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEY 126 L ++ AAG V V++SPHLVR+ ER+R+ G + ++ +E+A + +T+FE Sbjct: 63 LRAMAEAAGLTVHVFTSPHLVRFAERIRLAGTLITDAHLADVLERVEAANAGLPITFFEI 122 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T +AL F + D+ ++EVGLGG LDATN+V V+V+ I +DH ++LG +I + Sbjct: 123 TTAAALQAFSEVPADLCLVEVGLGGVLDATNVVSPVVSVIAPIDIDHREFLGDTLAAIAQ 182 Query: 187 EKAGIFRSEKPAIVGEPEMPSTIADVAQE--KGALLQRRGVEWNYSVTDHDWAFSDAHGT 244 EKAGI + P + + + A L G +++ Sbjct: 183 EKAGIIKPNTPVVSARQAEEAERVVEREADLSEAPLTLMGRDFDAWNERGRLLVQ-LQDR 241 Query: 245 LENLPLPL----VPQPNAATALAALRAS-GLEVSENAIRDGIASAILPGRFQIVSESPR- 298 L +LP P NA A+AA+ + E A+ GIA+ P RFQ ++ P Sbjct: 242 LLDLPAPSLPGEHQFANAGLAVAAILTLNDPRIDEAAMARGIAATTWPARFQRLTAGPLA 301 Query: 299 ---------VIFDVAHNPHAAEYLTGRMKALPK--NGRVLAVIGMLHDKDIAGTLAWLKS 347 + D HNPHA + + L V + G+L +KD G A S Sbjct: 302 ERAKAADADLWLDGGHNPHAGLAVARALGDLAARDGRPVALIAGLLANKDATGFFAPFAS 361 Query: 348 VVDDWYCAPLEGPRGATAEQLLEHLG----NGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 + + EG A+A Q + DSV +A D A+A + VL+CGS Sbjct: 362 LKARLFSVTFEGHAAASAAQTAAAAELAGIRAHACDSVREALDKALAI-EPTPHVLICGS 420 Query: 404 FHTVAHVME 412 + V+ Sbjct: 421 LYLAGEVLA 429 >UniRef50_A7HJX6 FolC bifunctional protein n=3 Tax=Thermotogaceae RepID=A7HJX6_FERNB Length = 435 Score = 399 bits (1026), Expect = e-109, Method: Composition-based stats. Identities = 109/423 (25%), Positives = 190/423 (44%), Gaps = 27/423 (6%) Query: 15 SWLSYLEN-LHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMA 73 L YL T+ LGL R+ + +++G F V G+NGKG+ LE++ Sbjct: 8 DILKYLYQTRPYNTMKLGLFRIEQLLSKMGNPHLGVKFFHVTGSNGKGSVTTFLENLTYY 67 Query: 74 AGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES-------ARGDISLTYFEY 126 G+ V + SPHL ER + + + ++ + S ++FEY Sbjct: 68 HGHNVTGFYSPHLSTILERFHWNTNLINQEEFVDAAEYVKKYAEEMDKIGEEFSPSFFEY 127 Query: 127 GTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGR 186 T L K + +EVGLGGR D+TN++ V+V+T+I+L+HT+ LG E I Sbjct: 128 MTAMYFHLTKVKNAEFGSVEVGLGGRFDSTNVITPVVSVITTISLEHTNVLGNTHEEIAF 187 Query: 187 EKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHG- 243 EKAGI +S P ++G E I ++A+E+G+ + G +++ V +D+ + + Sbjct: 188 EKAGIIKSGVPVVIGEMPEEAKIVIKNIAKERGSKVYEYGKDFSAEVVKYDFNNNIYNYY 247 Query: 244 ---TLENLPLPL---VPQPNAATALAALRASGLEVSENAIRDGIASAILPGRFQIVSESP 297 T++N+P+ L N A AL A ++ E +++ ++A +PGRF++ Sbjct: 248 GDSTVKNIPVRLNGVHQLYNLAIALKAYETVE-KLYEEKVQNAFSNAFIPGRFELFDG-- 304 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 +I D +HNP AAE ++ N + +A+ G++ DKD G L + D Sbjct: 305 -LILDGSHNPQAAEAFVSNIELYFSNKKRVALFGIVDDKDKMGVLEKIGPQFDTLIITRP 363 Query: 358 EGPRGATAEQLLEH----LGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 R ++ E N + + D + GSF+ + + + Sbjct: 364 PNKRAQKIDETYEIAKKYCKNVILEPDPIKGVELLKKI--DGDVKFITGSFYLIGLIRDY 421 Query: 414 IDA 416 + Sbjct: 422 LKN 424 >UniRef50_C0W165 Possible tetrahydrofolate synthase n=1 Tax=Actinomyces coleocanis DSM 15436 RepID=C0W165_9ACTO Length = 528 Score = 399 bits (1025), Expect = e-109, Method: Composition-based stats. Identities = 117/444 (26%), Positives = 196/444 (44%), Gaps = 36/444 (8%) Query: 7 PQAASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRT 66 L + L + L+R+ + LG + + V GTNGK +T R Sbjct: 87 EADYLALQEAI--LTRTPEHKFEPTLDRMLMAFNLLGDPQLSYRSVHVTGTNGKTSTSRM 144 Query: 67 LESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES----------AR 116 + ++L A+G KVG Y+SPHL ER+ V + + E ++A++ Sbjct: 145 ISALLQASGRKVGRYTSPHLTSMKERICVNEEPISERQFLEAYADVAPYIGMVDELGRRN 204 Query: 117 GDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDW 176 +++FE T++ L F +D ++EVG+GG DATN+++A+VAV T I +DH + Sbjct: 205 NGPQMSFFEVFTVTGLAAFADIPVDAAVVEVGIGGEWDATNVINAEVAVFTPIGVDHEAY 264 Query: 177 LGPDRESIGREKAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWN-----Y 229 LGP ES R K+GI + A+ PE+ + + A E GA+++ G E Sbjct: 265 LGPTAESAARIKSGIMKPGAIAVSAPQEPEVEAVLRAKAAEVGAVIRFIGQEVQLLDRKV 324 Query: 230 SVTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS-----GLEVSENAIRDGIASA 284 +V + +++ +PL + A A AL A G + + + +G A + Sbjct: 325 AVGGQVITVQTSAAVYQDIFVPLHGEHQAQNATLALAALEAFNGGRALEDRIVEEGFAMS 384 Query: 285 ILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAW 344 PGR ++V SP ++ D AHNPH A L ++ ++ V + DK + LA Sbjct: 385 TSPGRLEVVRTSPSILVDAAHNPHGASALAAALQESFDYSHIVGVYSAMADKQVEAVLAE 444 Query: 345 LKSVVDDWYCAPLEGPRGATAEQLLEHLGNGKSFDSVA------QAWDAAMADAKA---- 394 ++ ++D+ + R E+L E + D V A D A+ + A Sbjct: 445 MEPILDEIVITGMNSARAMDVEELAEVARDVFGEDRVHVERKLLDAVDKAVELSDATLDP 504 Query: 395 --EDTVLVCGSFHTVAHVMEVIDA 416 V+V GS E++ Sbjct: 505 ATSTGVVVFGSVVLAGSARELLLK 528 >UniRef50_Q1JBW2 Folylpolyglutamate synthase / Dihydrofolate synthase n=37 Tax=Streptococcus RepID=Q1JBW2_STRPB Length = 458 Score = 398 bits (1024), Expect = e-109, Method: Composition-based stats. Identities = 100/423 (23%), Positives = 181/423 (42%), Gaps = 23/423 (5%) Query: 11 SPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESI 70 L ++ + I GL+R+ V +LG + + GTNGKG+T L+ I Sbjct: 34 MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIVGTNGKGSTVNHLQHI 93 Query: 71 LMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-------SLTY 123 AGY+VG ++SP+++ + ER+ + G+ + E + I + +T Sbjct: 94 FTTAGYEVGTFTSPYIMDFKERISINGRMISEKDLVIAANRIRPLTERLVQETDFGEVTE 153 Query: 124 FEYGTLSALWLFKQ-AQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRE 182 FE TL F +D+ I+E GLGG D+TN+ A V V SI LDH LG Sbjct: 154 FEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAMVVVCPSIGLDHQAILGETYA 213 Query: 183 SIGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSD 240 I +KAG+ + + P A++ GA + ++ + + F+ Sbjct: 214 DIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWEWQEQFQMAENASGYRFTS 273 Query: 241 AHGTLENLPLPLVPQPNAATALAA------LRASGLEVSENAIRDGIASAILPGRFQIVS 294 G + ++ + + + A A L+ ++ + IR+G+A+++ GR +++ Sbjct: 274 PLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTSDHIREGLANSLWLGRTELL- 332 Query: 295 ESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYC 354 +P ++ D AHN + L +K + ++ + G + K IA L L+ + D Sbjct: 333 -APNLMIDGAHNNESVAALVAVLKNNYNDKKLHILFGAIDTKPIADMLVALEQIGD-LQV 390 Query: 355 APLEGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVI 414 P E+ E G F + A AKA+D ++ GS + ++ + + Sbjct: 391 TGFHYPNAYPLEKYPERFGRVADFKD----FLALRKHAKADDFFVITGSLYFISEIRQYW 446 Query: 415 DAR 417 Sbjct: 447 KKH 449 >UniRef50_B5Y836 Folylpolyglutamate synthase/dihydrofolate synthase n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y836_COPPD Length = 417 Score = 398 bits (1023), Expect = e-109, Method: Composition-based stats. Identities = 106/416 (25%), Positives = 174/416 (41%), Gaps = 20/416 (4%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 L L R+ + LG+ + V GT+GKG+ C L S Sbjct: 2 LDAYERISEELNQAPWFGRTPDLTRMDALLDELGLPQANTKNIIVTGTDGKGSVCSYLHS 61 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIES------ARGDISLTY 123 IL YKVG + SPHL +TER+ V ++ + + ++ T Sbjct: 62 ILGRR-YKVGRFISPHLEEWTERITVGKDDISKEDFARLYVKVMEGAKKACRVSGEMPTV 120 Query: 124 FEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRES 183 FE AL F++ + ++EVG+ G D+TN++ A VVTS+ +DH LG E Sbjct: 121 FERLLAMALLYFEEQGTEWNVIEVGIEGHYDSTNLLPAKAVVVTSVGMDHMRLLGNTIEE 180 Query: 184 IGREKAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDA 241 I + FR A++G +P + + A+ K A + R G ++ Y ++S + Sbjct: 181 IADAISAAFRPHAVAVIGKTDPAAMNILEVNARRKKATVYRYGRDFWY--DGKFLSYSGS 238 Query: 242 HGTLENLPLPLVPQPNAATALAALRASGL----EVSENAIRDGIASAILPGRFQIVSESP 297 L + NA+ A+ + A + + I++G+ A PGR + V E+P Sbjct: 239 LDFQLALR-GVHQWYNASAAIQTVLALSSTELNNIDASDIQEGLREAFWPGRMETVRENP 297 Query: 298 RVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPL 357 +I D AHNPHAA+ L + L + + DKD L + + Y + Sbjct: 298 LIILDGAHNPHAAQSLRTSLDLLYPGKKWNIFFAAMKDKDWRSVLTQFLDLANHVYVVRM 357 Query: 358 EGPRGATAEQLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEV 413 R + E ++E L + SV + + + + LV GS + V V + Sbjct: 358 PYERAESPETIVEFLKEKGTSSSVCE--EQDVIKCDEDA--LVFGSLYLVGDVRRL 409 >UniRef50_A9WDT0 FolC bifunctional protein n=4 Tax=Chloroflexi (class) RepID=A9WDT0_CHLAA Length = 438 Score = 398 bits (1023), Expect = e-109, Method: Composition-based stats. Identities = 114/434 (26%), Positives = 182/434 (41%), Gaps = 33/434 (7%) Query: 10 ASPLASWLSYLENLHSKTIDL-------------GLERVSLVAARLGVLKPAPFVFTVAG 56 + L Y+ + ID L R+ + G VAG Sbjct: 3 ITTYQEALDYIYSF----IDPTRQGSPDPAIAARSLARLRALLDIAGNPHQQLAAVVVAG 58 Query: 57 TNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESAR 116 T GKG+TC +E++ AAG +VG+++SPHL Y ER+++ + + ++ +++ Sbjct: 59 TKGKGSTCALIEAMARAAGLRVGLWTSPHLSSYRERIQIDREPISQATLIQLVRDVQPIV 118 Query: 117 GDIS------LTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIA 170 + F+ G + A+ F A +D+ ++EVGLGGR DA + +AV++SI+ Sbjct: 119 DAFDTATYGRPSTFDIGFVMAMRHFVAAHVDLAVVEVGLGGRFDAAATITPLIAVISSIS 178 Query: 171 LDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPEM--PSTIADVAQEKGALLQRRGVEWN 228 DH LGP I KAGI R +PAI + A AQ GA L Sbjct: 179 YDHMAILGPTLHDIAYNKAGIMRPGRPAITVPQHPEAAAVFAAEAQTVGAPLWLAAEHTV 238 Query: 229 YSVTDHDWAFSDAHGTLENLPLPLVPQPNAATA---LAALRASGLEVSENAIRDGIASAI 285 + + NA A LR G+ + + AIR G+A A Sbjct: 239 EPWLASGQPLTYPAPPQPGRLRGGFQRENARLAMGTALLLRDQGVPIDDQAIRRGLAEAW 298 Query: 286 LPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWL 345 PGRF++++ PR++ D AHN +A+ L + + + + V+G DKDIA A L Sbjct: 299 WPGRFELIAGPPRILIDGAHNGDSAQKLWQAISDELPHRQFILVLGTSRDKDIAAIAAAL 358 Query: 346 KSVVDDWYCAPLEGPRGATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLV 400 P+ +++ + + VA+A A A A+ +D + V Sbjct: 359 APQAAHVIITRSNHPKAMDLDRIAAEVAPFTNAPMQIVPVVAEALATAQALAEQDDLICV 418 Query: 401 CGSFHTVAHVMEVI 414 GS V E + Sbjct: 419 TGSLFVVGAAREAL 432 >UniRef50_D1VUP4 Tetrahydrofolate synthase n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VUP4_9FIRM Length = 422 Score = 398 bits (1023), Expect = e-109, Method: Composition-based stats. Identities = 91/422 (21%), Positives = 180/422 (42%), Gaps = 19/422 (4%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 +++ +L + +D +E V+ + +L + ++GTNGKG+ LE+ L Sbjct: 2 TYIKWLIERKTPMVDFTVENVAFLLEKLNNPQDRIKTIHISGTNGKGSLVFYLENALFFN 61 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-----LTYFEYGTL 129 YKVG ++SP++ + + + GQ++ + A+I ++ +T FE Sbjct: 62 NYKVGTFTSPYMTDINDSIEINGQKISNEDYENVLAKIYPIILEMDKINKYVTGFEIQVA 121 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVD-ADVAVVTSIALDHTDWLGPDRESIGREK 188 +A F + ++DV I+EVG+GGR DATN++ ++ TSI+LDH + LG + I K Sbjct: 122 AAFLYFYEKKVDVAIIEVGMGGRFDATNVMKSPLLSAFTSISLDHANLLGKTLKEIAWNK 181 Query: 189 AGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLE 246 GI + +P + E+ + ++A E + + + + + + + Sbjct: 182 GGIIKKSRPTFLYPQKEEVYKELKEIADENKSEIYKFDFSEINIINEDINGNEFSFREYK 241 Query: 247 NLPLPLVPQPNAATALAALRAS-----GLEVSENAIRDGIASAILPGRFQIVSESPRVIF 301 N+ L+ + A A AL + + IR GI P R +I+S+ P ++ Sbjct: 242 NIKTSLIGRHQAYNASLALSILSYLKNFFVLDDEKIRQGIYKTTNPARLEIISDEPLILM 301 Query: 302 DVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPR 361 D +HN + L + +++ +L DK+ + L D ++ R Sbjct: 302 DGSHNEESINSLISNLDK-FNYEKLILGFSILRDKEREKIIKNLAKYADTVVLTDIDSDR 360 Query: 362 GATAEQLLEHL-----GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 + L + +A + + A +D +L CGS + + + + Sbjct: 361 KSDINDLYNIFKSYTDKKIYMETDIEKAVNKTLELASKKDLILWCGSLYLMKDIRHFLKN 420 Query: 417 RR 418 + Sbjct: 421 HK 422 >UniRef50_B1I4S5 FolC bifunctional protein n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I4S5_DESAP Length = 425 Score = 397 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 131/422 (31%), Positives = 188/422 (44%), Gaps = 20/422 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 L + L + ++ GLERV + A LG + F + GTNGKG+ + +I Sbjct: 3 YEEALEAVRGLAATGVNFGLERVRELLAVLGDPQAGLFAAHIGGTNGKGSVAALVSAIAR 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIE----SARGDISLTYFEYGT 128 A G KVG ++SPHL YTER + GQ + + T FE T Sbjct: 63 AGGLKVGTFTSPHLSSYTERFLIDGQPVTGERLAGLITTHWNLLAPVARQVRPTEFELHT 122 Query: 129 LSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREK 188 + AL LF++ ++DV +LEVGLGGRLDATN++ VAV+T++ALDH ++LG I REK Sbjct: 123 VLALQLFREERVDVAVLEVGLGGRLDATNVIRPAVAVITNVALDHQEYLGETIAEIAREK 182 Query: 189 AGIFRSEKPAIV-GEPEMPSTIADVAQEKGALLQRRGVEWNYSVTD-----HDWAFSDAH 242 AGI + P + E IA +E A L R G + + D Sbjct: 183 AGIIKPGVPLVTAAEGGALDVIAGACRELDAPLVRVGADVRWEPRDDSGEKQGLDIYGRR 242 Query: 243 GTLENLPLPLVPQPNAAT------ALAALRASGLEVSENAIRDGIASAILPGRFQIVSES 296 L LPL + A L + AIR+G+A+ PGRF++++ Sbjct: 243 AVYRGLALPLAGRHQQVNAACAVAAAEVLGEHAPSLGPRAIREGLAAVNWPGRFEVLAGQ 302 Query: 297 PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAP 356 P V+ D AHNP AA L + A ++ V+G+L DKD AG A L Sbjct: 303 PTVVLDAAHNPAAAVVLRDTLVARFPGREIILVLGVLGDKDRAGIAAVLAPAARAVVVTR 362 Query: 357 LEGPRGATAEQLL----EHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 R E++ +H ++ A A A A V+V GS + + + Sbjct: 363 PPSERAGDWERVAVEAGKHCARVETVPDCRAALTRAQILAGAGGVVVVTGSIYLIGALRS 422 Query: 413 VI 414 I Sbjct: 423 AI 424 >UniRef50_B8GQE7 FolC bifunctional protein n=1 Tax=Thioalkalivibrio sp. HL-EbGR7 RepID=B8GQE7_THISH Length = 386 Score = 397 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 163/316 (51%), Positives = 211/316 (66%), Gaps = 9/316 (2%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 L WL++ E LH + IDLGLERV+ VAARL +L PA V TVAGTNGKG+T LE+ Sbjct: 3 FDTLDQWLAWQETLHPRAIDLGLERVARVAARLDLLTPACPVITVAGTNGKGSTVAMLEA 62 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 I AAGY+V Y+SPHL+RY ER+R+ G +++ +FA +++ARG+ +L+YFE+GTL Sbjct: 63 IYRAAGYRVCAYTSPHLLRYNERIRIHGSLADDASLCRAFAAVDAARGEDTLSYFEFGTL 122 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +ALWLF++A D+++LEVGLGGRLDA NIVD DV+VVTS+ +DH WLGPDRESIG EKA Sbjct: 123 AALWLFREAGADILVLEVGLGGRLDAVNIVDPDVSVVTSVGIDHEQWLGPDRESIGAEKA 182 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVT--DHDWAFSDAHG-TLE 246 GIFR+++PA+ G+P P++IA A GA L G +++SV W + L+ Sbjct: 183 GIFRAQRPAVCGDPTPPASIAGTAARLGAKLYAAGQAFSWSVDASGDHWQWRGPGDVVLD 242 Query: 247 NLPLPLV----PQPNAATALAA--LRASGLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 +LP P + NAATAL A L A V AI G+AS LPGRFQ + P VI Sbjct: 243 DLPPPALPGAIQFNNAATALTAVTLLAPRCPVPREAICRGLASVSLPGRFQRLRSDPAVI 302 Query: 301 FDVAHNPHAAEYLTGR 316 DVAHNP AE L Sbjct: 303 LDVAHNPQGAEVLAQN 318 >UniRef50_Q2GGC6 Folylpolyglutamate synthase n=11 Tax=Rickettsiales RepID=Q2GGC6_EHRCR Length = 435 Score = 397 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 117/406 (28%), Positives = 185/406 (45%), Gaps = 30/406 (7%) Query: 34 RVSLVAARLGVLKPAPF-VFTVAGTNGKGTTCRTLESILMAAGYKVGVYSSPHLVRYTER 92 R+ + RLG + V +AGTNGKG+T + IL +AG K +Y+SPHLV + ER Sbjct: 26 RMRQLLDRLGNPEKKLPPVIHIAGTNGKGSTISFIRYILNSAGLKTHIYTSPHLVEFNER 85 Query: 93 VRVQGQELPESAHTASFAEIESARGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGR 152 V + G+ + + A I +T+FE T + L F + D+V++E G+GGR Sbjct: 86 VVLAGKRISDQYLHEVIEICREASEGIPVTFFEGTTAAILLAFSKVDADIVLVETGVGGR 145 Query: 153 LDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKAGIFRSEKPAIVGEPE---MPSTI 209 LDATN+V + ++TSI+L+HT+ LG E I EKAGI + ++ + + + + Sbjct: 146 LDATNVVHPILNIITSISLEHTEALGNTVELIAGEKAGIMKENVTCVIAPQDQESIMNVL 205 Query: 210 ADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLPLPL----VPQPNAATALAAL 265 A +K L R G++W F + L PLP NA A+AA Sbjct: 206 EYHAIKKNVPLYRGGIDWFCERKGDSMLFKSSVDELL-FPLPSLRGEHQIINAGNAIAAC 264 Query: 266 RAS----GLEVSENAIRDGIASAILPGRFQIVSES---------PRVIFDVAHNPHAAEY 312 G + I G+ A P R + ++ + D AHNP E Sbjct: 265 SILSGKFGYNIDYENIVQGLKEAYWPARLEKITTGFLSKMVPQLWDLFLDGAHNPAGGEM 324 Query: 313 LTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEG-PRGATAEQLLEH 371 L+ ++ + +IGM +KD A L +LK + ++ PR TA +LL+ Sbjct: 325 LSRWIQNNELGD-LYIIIGMTREKDSAVFLNYLKPYIKFLSSVCIKSEPRAQTAAELLQT 383 Query: 372 LG----NGKSFDSVAQAWDAAMA--DAKAEDTVLVCGSFHTVAHVM 411 + ++A A + D + T+L+CGS + V+ Sbjct: 384 ALSLGIKAVAAKTLADAISKILEVGDCNRKSTILICGSLYLAGDVL 429 >UniRef50_A6WDS1 FolC bifunctional protein n=2 Tax=Actinomycetales RepID=A6WDS1_KINRD Length = 526 Score = 397 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 118/425 (27%), Positives = 192/425 (45%), Gaps = 31/425 (7%) Query: 2 IIKRTPQAASPLASWLSYLENLHS-KTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGK 60 + ++ + + I L+RV A LG + A V +AGTNGK Sbjct: 67 TPGPAVEDDPRFEEVVAQILARNPEHRIHPTLDRVREACALLGDPQTAYRVVHLAGTNGK 126 Query: 61 GTTCRTLESILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESA----- 115 +T R +E ++ + G ++SPHLV TER+ V G + +A ++ ++E Sbjct: 127 TSTARMVERLVREHDLRTGRFTSPHLVDITERIAVDGDPITHAAFVRAWDDVEPVVSIVD 186 Query: 116 -----RGDISLTYFEYGTLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIA 170 RG+ L++FE TL A F A +DV ++E GLGG D TN+V DVAVVT ++ Sbjct: 187 ARAAERGEPRLSFFEVLTLMAFAAFADAPVDVAVIETGLGGTWDTTNVVQPDVAVVTPVS 246 Query: 171 LDHTDWLGPDRESIGREKAGIFRSEKPAIVGEP--EMPSTIADVAQEKGALLQRRGVEWN 228 +DH WLG E I +KAGI + ++G+ E + + A + + R GV++ Sbjct: 247 MDHEAWLGSTLEEIAGQKAGIIKHGSIVVIGKQEEEAGAVLTAKAAAERVNVVREGVDFG 306 Query: 229 YS-----VTDHDWAFSDAHGTLENLPLPLVPQPNAATALAALRAS-------GLEVSENA 276 V + GT ++ LPL A A AL A+ G + Sbjct: 307 VEERALAVGGQLVSLRTRGGTYTDVLLPLHGVHQAENAATALSAAEALLALPGGTLVPGL 366 Query: 277 IRDGIASAILPGRFQIVSESPRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDK 336 + A PGR +++ SP V+ D AHNP A+ L + R++ V+ ++ DK Sbjct: 367 VEAAFADVTSPGRLEVLRTSPLVLVDAAHNPAGAQALADAVAEAFTLSRLVGVVAVMGDK 426 Query: 337 DIAGTLAWLKSVVDDWYCAPLEGPRGATAEQLLEHLGN------GKSFDSVAQAWDAAMA 390 D+ G L+ L+ V+ + PRG +L E + + + +A A+ Sbjct: 427 DVEGVLSALEPVLAEVVVTRSSSPRGLEPAELAEIAEDVFGEDRVHLVERLDEAIATAVD 486 Query: 391 DAKAE 395 A+++ Sbjct: 487 LAESD 491 >UniRef50_C7GYL0 Tetrahydrofolate synthase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7GYL0_9FIRM Length = 441 Score = 396 bits (1019), Expect = e-109, Method: Composition-based stats. Identities = 120/434 (27%), Positives = 187/434 (43%), Gaps = 31/434 (7%) Query: 15 SWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILMAA 74 + + +++L LGL+R++ + A LGV + VAGTNGKG+ C L+ IL A Sbjct: 3 NAVDKIKSLGRFGSKLGLDRMNRLMAELGVSCADFKIIHVAGTNGKGSVCTMLDKILRAH 62 Query: 75 GYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDIS-------LTYFEYG 127 G K G+Y+SP+L Y + + V G+ + + A + +T FE Sbjct: 63 GIKTGMYTSPYLSNYRDSIAVDGRSISCEDLDRVGETVLEAADKLPKEDGELAVTEFEVI 122 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T AL+ FK+ + VILE GLGG LD+TNI A VAV+TSI+ DH D LG I + Sbjct: 123 TGLALYYFKEVGAEYVILETGLGGALDSTNIAPAKVAVITSISYDHMDVLGDSLAEIAKN 182 Query: 188 KAGIFRSEKPAIVG--EPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAF-----SD 240 KAGI + A+V E E S I + +K A + R + D++ F S Sbjct: 183 KAGIIKEGATAVVNVDEEEALSVIKNEVCKKHANIVRADEAVKINSVDYNKKFSLVDMST 242 Query: 241 AHGTLENLPLPLVPQPNAAT---ALAAL----RASGLEVSENAIRDGIASAILPGRFQIV 293 A + L+ + + +A + A G + + GRF++ Sbjct: 243 ASQNYGRIKFSLLGKHQLSNLKTVIATVGELKSAFGFCERHEITVEALGDVHFSGRFEVF 302 Query: 294 SES---PRVIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVD 350 ++ D AHN E L +K N ++LAV ML DK + L L + Sbjct: 303 EGDAGCADIVLDGAHNVAGIEALEQNVKLYYPNAKILAVTSMLGDKQVDEILHRLCKFSN 362 Query: 351 DWYCAPLEGPRGATAEQLLEHLG-------NGKSFDSVAQAWDAAMADAKAEDTVLVCGS 403 D + R +A ++LE N + +A+ A + D +L GS Sbjct: 363 DVIFTEINNERRISAHEMLEIAKQSEGNTGNYQEIPDTGKAFTQAYDSRRNYDLILFTGS 422 Query: 404 FHTVAHVMEVIDAR 417 + + + + Sbjct: 423 LYMMGDIRRRLHDE 436 >UniRef50_Q6MAP9 Putative folylpolyglutamate synthase n=1 Tax=Candidatus Protochlamydia amoebophila UWE25 RepID=Q6MAP9_PARUW Length = 410 Score = 396 bits (1019), Expect = e-109, Method: Composition-based stats. Identities = 126/417 (30%), Positives = 196/417 (47%), Gaps = 39/417 (9%) Query: 11 SPLASWLSYLENLHSKT-IDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 P + + L L+ I LGL + L + VAGTNGKG+ + S Sbjct: 1 MPYSELIQRLFALNLHGGIKLGLSNCEKLQTILKFPDHSFSSIHVAGTNGKGSVVAKIAS 60 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGD--ISLTYFEYG 127 L AGY+VGVY+SPH+ + ER+RV G + E+ +++ + I T+FE Sbjct: 61 ALEYAGYRVGVYTSPHISSFRERIRVNGIMISEADVEKILSQLFNLTAQYSIPATFFELT 120 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T AL F + ++D +LE GLGGRLDATNIV ++++TSI+LDHTD LG E+I +E Sbjct: 121 TFLALVYFSREKVDFAVLEAGLGGRLDATNIVSPVLSIITSISLDHTDILGDTLEAIAKE 180 Query: 188 KAGIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLEN 247 KAGI +S P I+G I +A +K + + +++ + F Sbjct: 181 KAGIIKSHTPVIIGPQTPYLFIEKLAYQKNS--------FCHTIKNQFLLFD-------- 224 Query: 248 LPLPLVPQPNAATALAALRAS--GLEVSENAIRDGIASAILPGRFQIVSESPRVIFDVAH 305 Q N A A +L ++ + AI G+ A P RF+I++ S VI DVAH Sbjct: 225 -------QENNAIAKKSLEVLSENWDIPQEAIFKGLE-AKQPCRFEIINNS--VILDVAH 274 Query: 306 NPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATA 365 NP L + + N + + G+ KD+ G L L ++ RG + Sbjct: 275 NPSGLTSLFAKTQTHFPNQPLRILFGLSKGKDLEGCLKILSRHGSAFHLVEAPNGRGISF 334 Query: 366 EQLLEHLGNGKSFDSV-------AQAWDAAMADAK-AEDTVLVCGSFHTVAHVMEVI 414 + L + L N +V + A+ A+ + +L+CGSF ++ V + + Sbjct: 335 DLLKQGLMNTGIASTVIYSHINIQEGVKIAIKQAESSGQLLLICGSFFIMSQVRQAL 391 >UniRef50_C8NGA7 FolC bifunctional protein n=1 Tax=Granulicatella adiacens ATCC 49175 RepID=C8NGA7_9LACT Length = 423 Score = 395 bits (1017), Expect = e-108, Method: Composition-based stats. Identities = 114/426 (26%), Positives = 183/426 (42%), Gaps = 28/426 (6%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 + WL E++ GL R+ + LG + +AGTNGKG+T + + Sbjct: 2 IQEWLKKSESIPR---KHGLYRMEAILGALGNPERELKSIHIAGTNGKGSTAAMVTAFAK 58 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDI-----SLTYFEYG 127 A G +VG ++SPH+ ER+++ G L E + + + + + YFE Sbjct: 59 AHGLRVGTFTSPHMDSIRERIQLDGVPLEEEPFWQAASVVREVESRLFEEWGAFNYFEIL 118 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T +F+Q +D+ I+EVG+GG LD TN+ V+V+T+I LDH D LG E I + Sbjct: 119 TAMMFVVFQQEAVDLAIIEVGIGGLLDNTNVGHPLVSVITTIGLDHQDLLGSSLEEITAQ 178 Query: 188 KAGIFRSEKPAIVGE--PEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTL 245 KAGI +S + +VG E I VA EKGA +Q G ++ ++ D T+ Sbjct: 179 KAGIIKSGQQVVVGPVTRECMDVIRGVASEKGAAVQAFGEAFSLVED----SYQDEALTI 234 Query: 246 ENLPLPLV---PQPNAATALAAL----RASGLEVSENAIRDGIASAILPGRFQIVSESPR 298 L L + NA+ A+ A A+G + I + PGR +++ ++P Sbjct: 235 PLGQLALHGAFQKENASVAIRACQAWMEATGRSMQAEFIEAALPVVSWPGRMEVLQDTPL 294 Query: 299 VIFDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDW--YCAP 356 +I D AHN A E L M + + L KD LA L+ + D Sbjct: 295 IIIDGAHNLPAIERLIQNMTERF-GKKQTLLFSALTRKDSQQMLARLQEALPDVNIILTS 353 Query: 357 LEGPRGATAE----QLLEHLGNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVME 412 RG + + +S + + + + V GS + +A V Sbjct: 354 FHPSRGLSIARSDVEAYLDSPKISFEESFEEVIERFACSIDDKSELWVTGSLYFIAEVRH 413 Query: 413 VIDARR 418 + R+ Sbjct: 414 WWNNRK 419 >UniRef50_Q8EPN5 Folyl-polyglutamate synthase n=1 Tax=Oceanobacillus iheyensis RepID=Q8EPN5_OCEIH Length = 426 Score = 395 bits (1017), Expect = e-108, Method: Composition-based stats. Identities = 96/418 (22%), Positives = 175/418 (41%), Gaps = 17/418 (4%) Query: 13 LASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLESILM 72 Y N + + GLERV + + +AGTNGKG+T + ++S L+ Sbjct: 3 FEQIEQYFNNRETIGVQPGLERVKELLKFVDYPDKDLPTIHIAGTNGKGSTSQFIQSALI 62 Query: 73 AAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARG-----DISLTYFEYG 127 A YKVG ++SP +++ + + E + +F ++ A S + FE Sbjct: 63 ANDYKVGSFTSPSFYGIRGFIQMNNEPVSEKVFSQAFQKMLPAIEMLDKDGNSPSNFEIL 122 Query: 128 TLSALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGRE 187 T+ + F + +D+ ++E G+GG D TN++ V V+T+I+ DHT LG I + Sbjct: 123 TVLSFVCF-ENNVDIAVVEAGMGGMWDTTNVISPIVTVITTISYDHTALLGETLVEIAEQ 181 Query: 188 KAGIFRSEKPAIVG-EPEMPSTIADVAQEKGALLQRRGVEWNYS---VTDHDWAFSDAHG 243 KAGI + P I G I +E + L ++ Y + + S+ Sbjct: 182 KAGIIKPLIPMITGVNGTAYDIIEKKTEEMNSPLFVLDKDFTYESITMNHFKFNISNQQF 241 Query: 244 TLENLPLPLVPQPNAATALAALRAS---GLEVSENAIRDGIASAILPGRFQIVSESPRVI 300 ++ NA+ AL L G +++E+ I G+ A LPGR + + +P +I Sbjct: 242 DIDLDMNGKHQHYNASIALYVLHILHEQGWQLTEDKIIKGVEQARLPGRLEKIHSNPSII 301 Query: 301 FDVAHNPHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGP 360 D AHN L +K + DKD+ + L+S + + + Sbjct: 302 VDGAHNMEGIHSLIDTIKRQDSKSGHHILFAAFKDKDVRNMINCLQSDLSNVNVTTFDHV 361 Query: 361 RGATAEQLLEHLGN--GKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDA 416 R + E+L + + + + + ++ + GS H ++ V + ++ Sbjct: 362 RAPSFEELEQLETKQPKRIVYDWKKYLETIFEN--KDECYYITGSLHFISLVKQYVND 417 >UniRef50_A1AXP8 FolC bifunctional protein n=5 Tax=Bacteria RepID=A1AXP8_RUTMC Length = 404 Score = 395 bits (1017), Expect = e-108, Method: Composition-based stats. Identities = 141/417 (33%), Positives = 220/417 (52%), Gaps = 25/417 (5%) Query: 10 ASPLASWLSYLENLHSKTIDLGLERVSLVAARLGVLKPAPFVFTVAGTNGKGTTCRTLES 69 + L WL++ +NLH K IDLGLERV+ V +L + V TVAGTNGKG+T + Sbjct: 4 LNTLDDWLNFQKNLHFKKIDLGLERVTKVYQKLFPKGISFKVITVAGTNGKGSTAAFING 63 Query: 70 ILMAAGYKVGVYSSPHLVRYTERVRVQGQELPESAHTASFAEIESARGDISLTYFEYGTL 129 I + +KV +SSPH+++Y ER + + + ++F +IE RG +LTYFE+ TL Sbjct: 64 IYQQSNFKVAKFSSPHILKYNERFVINDAQATDEQICSAFNKIEQIRGKTTLTYFEFSTL 123 Query: 130 SALWLFKQAQLDVVILEVGLGGRLDATNIVDADVAVVTSIALDHTDWLGPDRESIGREKA 189 +AL +F+ ++++ ILEVGLGGRLD+ NIVD DV+++T+I +DH D+LG RE IG EKA Sbjct: 124 AALIIFELEKVNIAILEVGLGGRLDSVNIVDNDVSIITNIDIDHVDYLGDTRELIGFEKA 183 Query: 190 GIFRSEKPAIVGEPEMPSTIADVAQEKGALLQRRGVEWNYSVTDHDWAFSDAHGTLENLP 249 GI R P I + P++I+ A + A L+ + S+ Sbjct: 184 GIMRKNIPCICADINPPASISQYAHQIKAQLEFVKQRYTGSIG----------------L 227 Query: 250 LPLVPQPNAATALAALRASG--LEVSENAIRDGIASAILPGRFQI-VSESPRVIFDVAHN 306 + Q NAATA+ ++ L +S I GI L RFQI + + VIFDVAHN Sbjct: 228 IGKHQQQNAATAILTVQKLHKTLPISTIEIETGIKCTQLDARFQIKIINNKTVIFDVAHN 287 Query: 307 PHAAEYLTGRMKALPKNGRVLAVIGMLHDKDIAGTLAWLKSVVDDWYCAPLEGPRGATAE 366 A + L+ + + +A+ L DK+I + + ++D W PL R + Sbjct: 288 AAAVKVLSAELAKQKCS--TIAIFSALEDKNIGLMINKISVIIDQWLLVPLNVSRAIGMK 345 Query: 367 QLLEHL---GNGKSFDSVAQAWDAAMADAKAEDTVLVCGSFHTVAHVMEVIDARRSG 420 L N + D++ A + + D + +++ GSFH +A ++++ + Sbjct: 346 ALSNQFDLTQNIRVCDNMQDAINQGLNDNQ-HQRIVIFGSFHVIADALKILTPFKKN 401 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.314 0.181 0.566 Lambda K H 0.267 0.0553 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 3,107,329,479 Number of Sequences: 3077464 Number of extensions: 171486720 Number of successful extensions: 468543 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 2326 Number of HSP's successfully gapped in prelim test: 1907 Number of HSP's that attempted gapping in prelim test: 453177 Number of HSP's gapped (non-prelim): 7225 length of query: 422 length of database: 1,040,396,356 effective HSP length: 131 effective length of query: 291 effective length of database: 637,248,572 effective search space: 185439334452 effective search space used: 185439334452 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 95 (40.8 bits)