Phyre 2 Results for P0AFQ7

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Email | l.a.kelley@imperial.ac.uk
Description | P0AFQ7
Date | Thu Jan 5 11:27:00 GMT 2012
Unique Job ID | 196b79b259aef46e

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template d1yixa1
Top template information
Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like
Confidence and coverage
Confidence: | 100.0% | Coverage: | 100%
265 residues (100% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | F | L | V | D | S | H | C | H | L | D | G | L | D | Y | E | S | L | H | K | D | V | D | D | V | L | A | K | A | A | A | R | D | V | K | F | C | L | A | V | A | T | T | L | P | G | Y | L | H | M | R | D | L | V | G | E | R | D | N | V
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | V | F | S | C | G | V | H | P | L | N | Q | N | D | P | Y | D | V | E | D | L | R | R | L | A | A | E | E | G | V | V | A | L | G | E | T | G | L | D | Y | Y | Y | T | P | E | T | K | V | R | Q | Q | E | S | F | I | H | H | I | Q | I | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | R | E | L | N | K | P | V | I | V | H | T | R | D | A | R | A | D | T | L | A | I | L | R | E | E | K | V | T | D | C | G | G | V | L | H | C | F | T | E | D | R | E | T | A | G | K | L | L | D | L | G | F | Y | I | S | F | S | G | I | V
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | T | F | R | N | A | E | Q | L | R | D | A | A | R | Y | V | P | L | D | R | L | L | V | E | T | D | S | P | Y | L | A | P | V | P | H | R | G | K | E | N | Q | P | A | M | V | R | D | V | A | E | Y | M | A | V | L | K | G | V | A | V | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | .
Sequence |  | E | L | A | Q | V | T | T | D | N | F | A | R | L | F | H | I | D | A | S | R | L | Q | S | I | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| d1yixa1 |

### PDB 1yix chain A domain 1

Region: 1 - 265
Aligned: 265
Modelled: 265
Confidence: 100.0%
Identity: 100%
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Family: TatD Mg-dependent DNase-like

Phyre2
2 |
| d1j6oa_ |

### PDB 1j6o chain A

Region: 3 - 255
Aligned: 250
Modelled: 252
Confidence: 100.0%
Identity: 35%
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Family: TatD Mg-dependent DNase-like

Phyre2
3 |
| d1xwya1 |

### PDB 1xwy chain A domain 1

Region: 3 - 256
Aligned: 251
Modelled: 254
Confidence: 100.0%
Identity: 33%
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Family: TatD Mg-dependent DNase-like

Phyre2
4 |
| c3rcmA_ |

### PDB 3rcm chain A

Region: 2 - 260
Aligned: 256
Modelled: 256
Confidence: 100.0%
Identity: 28%
PDB header:hydrolase
Chain: A: PDB Molecule:tatd family hydrolase;
PDBTitle: crystal structure of efi target 500140:tatd family hydrolase from2 pseudomonas putida

Phyre2
5 |
| c2gzxB_ |

### PDB 2gzx chain B

Region: 3 - 255
Aligned: 250
Modelled: 253
Confidence: 100.0%
Identity: 38%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:putative tatd related dnase;
PDBTitle: crystal structure of the tatd deoxyribonuclease mw0446 from2 staphylococcus aureus. northeast structural genomics consortium3 target zr237.

Phyre2
6 |
| c2xioA_ |

### PDB 2xio chain A

Region: 1 - 255
Aligned: 253
Modelled: 255
Confidence: 100.0%
Identity: 26%
PDB header:hydrolase
Chain: A: PDB Molecule:putative deoxyribonuclease tatdn1;
PDBTitle: structure of putative deoxyribonuclease tatdn1 isoform a

Phyre2
7 |
| d1zzma1 |

### PDB 1zzm chain A domain 1

Region: 1 - 257
Aligned: 253
Modelled: 257
Confidence: 100.0%
Identity: 28%
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Family: TatD Mg-dependent DNase-like

Phyre2
8 |
| c3ipwA_ |

### PDB 3ipw chain A

Region: 1 - 254
Aligned: 252
Modelled: 254
Confidence: 100.0%
Identity: 25%
PDB header:hydrolase
Chain: A: PDB Molecule:hydrolase tatd family protein;
PDBTitle: crystal structure of hydrolase tatd family protein from entamoeba2 histolytica

Phyre2
9 |
| c2y1hA_ |

### PDB 2y1h chain A

Region: 1 - 255
Aligned: 246
Modelled: 255
Confidence: 100.0%
Identity: 33%
PDB header:hydrolase
Chain: A: PDB Molecule:putative deoxyribonuclease tatdn3;
PDBTitle: crystal structure of the human tatd-domain protein 3 (tatdn3)

Phyre2
10 |
| c3e2vA_ |

### PDB 3e2v chain A

Region: 1 - 255
Aligned: 255
Modelled: 255
Confidence: 100.0%
Identity: 27%
PDB header:hydrolase
Chain: A: PDB Molecule:3'-5'-exonuclease;
PDBTitle: crystal structure of an uncharacterized amidohydrolase from2 saccharomyces cerevisiae

Phyre2
11 |
| c3gg7A_ |

### PDB 3gg7 chain A

Region: 3 - 255
Aligned: 239
Modelled: 249
Confidence: 100.0%
Identity: 24%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized metalloprotein;
PDBTitle: crystal structure of an uncharacterized metalloprotein from2 deinococcus radiodurans

Phyre2
12 |
| d2ffia1 |

### PDB 2ffi chain A domain 1

Region: 1 - 257
Aligned: 239
Modelled: 257
Confidence: 100.0%
Identity: 14%
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Family: PP1699/LP2961-like

Phyre2
13 |
| c3irsB_ |

### PDB 3irs chain B

Region: 1 - 256
Aligned: 235
Modelled: 243
Confidence: 100.0%
Identity: 14%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:uncharacterized protein bb4693;
PDBTitle: crystal structure of uncharacterized tim-barrel protein bb4693 from2 bordetella bronchiseptica

Phyre2
14 |
| c2wm1A_ |

### PDB 2wm1 chain A

Region: 2 - 257
Aligned: 237
Modelled: 244
Confidence: 100.0%
Identity: 17%
PDB header:lyase
Chain: A: PDB Molecule:2-amino-3-carboxymuconate-6-semialdehyde
PDBTitle: the crystal structure of human alpha-amino-beta-2 carboxymuconate-epsilon-semialdehyde decarboxylase in3 complex with 1,3- dihydroxyacetonephosphate suggests a4 regulatory link between nad synthesis and glycolysis

Phyre2
15 |
| c3ij6A_ |

### PDB 3ij6 chain A

Region: 1 - 255
Aligned: 237
Modelled: 246
Confidence: 100.0%
Identity: 17%
PDB header:hydrolase
Chain: A: PDB Molecule:uncharacterized metal-dependent hydrolase;
PDBTitle: crystal structure of an uncharacterized metal-dependent2 hydrolase from lactobacillus acidophilus

Phyre2
16 |
| d2f6ka1 |

### PDB 2f6k chain A domain 1

Region: 4 - 255
Aligned: 232
Modelled: 235
Confidence: 100.0%
Identity: 17%
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Family: PP1699/LP2961-like

Phyre2
17 |
| d2gwga1 |

### PDB 2gwg chain A domain 1

Region: 3 - 258
Aligned: 253
Modelled: 256
Confidence: 100.0%
Identity: 15%
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Family: PP1699/LP2961-like

Phyre2
18 |
| c3guwB_ |

### PDB 3guw chain B

Region: 3 - 256
Aligned: 213
Modelled: 238
Confidence: 100.0%
Identity: 24%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:uncharacterized protein af_1765;
PDBTitle: crystal structure of the tatd-like protein (af1765) from2 archaeoglobus fulgidus, northeast structural genomics3 consortium target gr121

Phyre2
19 |
| d2hbva1 |

### PDB 2hbv chain A domain 1

Region: 3 - 257
Aligned: 235
Modelled: 242
Confidence: 100.0%
Identity: 19%
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Family: PP1699/LP2961-like

Phyre2
20 |
| d2dvta1 |

### PDB 2dvt chain A domain 1

Region: 3 - 257
Aligned: 239
Modelled: 241
Confidence: 100.0%
Identity: 18%
Fold: TIM beta/alpha-barrel
Superfamily: Metallo-dependent hydrolases
Family: PP1699/LP2961-like

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | d1yixa1 |
|  | 100.0 | 100 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like
2 | d1j6oa_ |
|  | 100.0 | 35 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like
3 | d1xwya1 |
|  | 100.0 | 33 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like
4 | c3rcmA_ |
|  | 100.0 | 28 | PDB header:hydrolase Chain: A: PDB Molecule:tatd family hydrolase; PDBTitle: crystal structure of efi target 500140:tatd family hydrolase from2 pseudomonas putida
5 | c2gzxB_ |
|  | 100.0 | 38 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative tatd related dnase; PDBTitle: crystal structure of the tatd deoxyribonuclease mw0446 from2 staphylococcus aureus. northeast structural genomics consortium3 target zr237.
6 | c2xioA_ |
|  | 100.0 | 26 | PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyribonuclease tatdn1; PDBTitle: structure of putative deoxyribonuclease tatdn1 isoform a
7 | d1zzma1 |
|  | 100.0 | 28 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:TatD Mg-dependent DNase-like
8 | c3ipwA_ |
|  | 100.0 | 25 | PDB header:hydrolase Chain: A: PDB Molecule:hydrolase tatd family protein; PDBTitle: crystal structure of hydrolase tatd family protein from entamoeba2 histolytica
9 | c2y1hA_ |
|  | 100.0 | 33 | PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyribonuclease tatdn3; PDBTitle: crystal structure of the human tatd-domain protein 3 (tatdn3)
10 | c3e2vA_ |
|  | 100.0 | 27 | PDB header:hydrolase Chain: A: PDB Molecule:3'-5'-exonuclease; PDBTitle: crystal structure of an uncharacterized amidohydrolase from2 saccharomyces cerevisiae
11 | c3gg7A_ |
|  | 100.0 | 24 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized metalloprotein; PDBTitle: crystal structure of an uncharacterized metalloprotein from2 deinococcus radiodurans
12 | d2ffia1 |
|  | 100.0 | 14 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:PP1699/LP2961-like
13 | c3irsB_ |
|  | 100.0 | 14 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein bb4693; PDBTitle: crystal structure of uncharacterized tim-barrel protein bb4693 from2 bordetella bronchiseptica
14 | c2wm1A_ |
|  | 100.0 | 17 | PDB header:lyase Chain: A: PDB Molecule:2-amino-3-carboxymuconate-6-semialdehyde PDBTitle: the crystal structure of human alpha-amino-beta-2 carboxymuconate-epsilon-semialdehyde decarboxylase in3 complex with 1,3- dihydroxyacetonephosphate suggests a4 regulatory link between nad synthesis and glycolysis
15 | c3ij6A_ |
|  | 100.0 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized metal-dependent hydrolase; PDBTitle: crystal structure of an uncharacterized metal-dependent2 hydrolase from lactobacillus acidophilus
16 | d2f6ka1 |
|  | 100.0 | 17 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:PP1699/LP2961-like
17 | d2gwga1 |
|  | 100.0 | 15 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:PP1699/LP2961-like
18 | c3guwB_ |
|  | 100.0 | 24 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein af_1765; PDBTitle: crystal structure of the tatd-like protein (af1765) from2 archaeoglobus fulgidus, northeast structural genomics3 consortium target gr121
19 | d2hbva1 |
|  | 100.0 | 19 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:PP1699/LP2961-like
20 | d2dvta1 |
|  | 100.0 | 18 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:PP1699/LP2961-like
21 | c3cjpA_ |
| not modelled | 100.0 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:predicted amidohydrolase, dihydroorotase family; PDBTitle: crystal structure of an uncharacterized amidohydrolase cac3332 from2 clostridium acetobutylicum
22 | c2qahA_ |
| not modelled | 100.0 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:2-pyrone-4,6-dicarboxylic acid hydrolase; PDBTitle: crystal structure of the 2-pyrone-4,6-dicarboxylic acid2 hydrolase from sphingomonas paucimobilis
23 | c3nurA_ |
| not modelled | 100.0 | 19 | PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of a putative amidohydrolase from staphylococcus2 aureus
24 | d1bf6a_ |
| not modelled | 100.0 | 14 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Phosphotriesterase-like
25 | c3f4cA_ |
| not modelled | 99.9 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:organophosphorus hydrolase; PDBTitle: crystal structure of organophosphorus hydrolase from geobacillus2 stearothermophilus strain 10, with glycerol bound
26 | c2vc7A_ |
| not modelled | 99.9 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:aryldialkylphosphatase; PDBTitle: structural basis for natural lactonase and promiscuous2 phosphotriesterase activities
27 | d2d2ja1 |
| not modelled | 99.9 | 21 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Phosphotriesterase-like
28 | c3pnzD_ |
| not modelled | 99.9 | 16 | PDB header:hydrolase Chain: D: PDB Molecule:phosphotriesterase family protein; PDBTitle: crystal structure of the lactonase lmo2620 from listeria monocytogenes
29 | d1i0da_ |
| not modelled | 99.9 | 19 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Phosphotriesterase-like
30 | c1pscA_ |
| not modelled | 99.9 | 19 | PDB header:hydrolase Chain: A: PDB Molecule:phosphotriesterase; PDBTitle: phosphotriesterase from pseudomonas diminuta
31 | c2zc1A_ |
| not modelled | 99.9 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:phosphotriesterase; PDBTitle: organophosphorus hydrolase from deinococcus radiodurans
32 | c3k2gA_ |
| not modelled | 99.8 | 16 | PDB header:resiniferatoxin binding protein Chain: A: PDB Molecule:resiniferatoxin-binding, phosphotriesterase- PDBTitle: crystal structure of a resiniferatoxin-binding protein from2 rhodobacter sphaeroides
33 | c3rhgA_ |
| not modelled | 99.8 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:putative phophotriesterase; PDBTitle: crystal structure of amidohydrolase pmi1525 (target efi-500319) from2 proteus mirabilis hi4320
34 | d1xrta2 |
| not modelled | 99.8 | 14 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain
35 | c3msrA_ |
| not modelled | 99.6 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolases; PDBTitle: the crystal structure of an amidohydrolase from mycoplasma synoviae
36 | c2qpxA_ |
| not modelled | 99.6 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:predicted metal-dependent hydrolase of the tim-barrel fold; PDBTitle: crystal structure of putative metal-dependent hydrolase (yp_805737.1)2 from lactobacillus casei atcc 334 at 1.40 a resolution
37 | c3pnuA_ |
| not modelled | 99.6 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:dihydroorotase; PDBTitle: 2.4 angstrom crystal structure of dihydroorotase (pyrc) from2 campylobacter jejuni.
38 | d1nfga2 |
| not modelled | 99.6 | 16 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain
39 | d1k1da2 |
| not modelled | 99.6 | 18 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain
40 | d1ynya2 |
| not modelled | 99.5 | 16 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain
41 | d1gkra2 |
| not modelled | 99.5 | 15 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain
42 | c3nqbB_ |
| not modelled | 99.5 | 16 | PDB header:hydrolase Chain: B: PDB Molecule:adenine deaminase 2; PDBTitle: crystal structure of adenine deaminase from agrobacterium tumefaciens2 (str. c 58)
43 | d2ftwa2 |
| not modelled | 99.5 | 17 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain
44 | c1xrfA_ |
| not modelled | 99.5 | 12 | PDB header:hydrolase Chain: A: PDB Molecule:dihydroorotase; PDBTitle: the crystal structure of a novel, latent dihydroorotase from aquifex2 aeolicus at 1.7 a resolution
45 | d2eg6a1 |
| not modelled | 99.5 | 15 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Dihydroorotase
46 | d1gkpa2 |
| not modelled | 99.4 | 16 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain
47 | d2fvka2 |
| not modelled | 99.4 | 11 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain
48 | d2uz9a2 |
| not modelled | 99.4 | 11 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:SAH/MTA deaminase-like
49 | d2icsa2 |
| not modelled | 99.4 | 16 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Adenine deaminase-like
50 | d1kcxa2 |
| not modelled | 99.4 | 12 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Hydantoinase (dihydropyrimidinase), catalytic domain
51 | d1onwa2 |
| not modelled | 99.4 | 12 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Isoaspartyl dipeptidase, catalytic domain
52 | c3jzeC_ |
| not modelled | 99.4 | 15 | PDB header:hydrolase Chain: C: PDB Molecule:dihydroorotase; PDBTitle: 1.8 angstrom resolution crystal structure of dihydroorotase (pyrc)2 from salmonella enterica subsp. enterica serovar typhimurium str. lt2
53 | c2vunC_ |
| not modelled | 99.4 | 14 | PDB header:hydrolase Chain: C: PDB Molecule:enamidase; PDBTitle: the crystal structure of enamidase at 1.9 a resolution - a2 new member of the amidohydrolase superfamily
54 | d2paja2 |
| not modelled | 99.3 | 12 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:SAH/MTA deaminase-like
55 | d2imra2 |
| not modelled | 99.3 | 11 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:DR0824-like
56 | d2i9ua2 |
| not modelled | 99.3 | 11 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:SAH/MTA deaminase-like
57 | d1p1ma2 |
| not modelled | 99.3 | 14 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:SAH/MTA deaminase-like
58 | c3e0lB_ |
| not modelled | 99.3 | 12 | PDB header:hydrolase Chain: B: PDB Molecule:guanine deaminase; PDBTitle: computationally designed ammelide deaminase
59 | d3be7a2 |
| not modelled | 99.3 | 21 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Zn-dependent arginine carboxypeptidase-like
60 | d1yrra2 |
| not modelled | 99.2 | 14 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain
61 | d2r8ca2 |
| not modelled | 99.2 | 16 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Zn-dependent arginine carboxypeptidase-like
62 | d2p9ba2 |
| not modelled | 99.2 | 16 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Imidazolonepropionase-like
63 | d2qs8a2 |
| not modelled | 99.2 | 18 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Zn-dependent arginine carboxypeptidase-like
64 | d2bb0a2 |
| not modelled | 99.2 | 15 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Imidazolonepropionase-like
65 | c3hpaB_ |
| not modelled | 99.2 | 11 | PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of an amidohydrolase gi:44264246 from an2 evironmental sample of sargasso sea
66 | c1p1mA_ |
| not modelled | 99.2 | 14 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein tm0936; PDBTitle: structure of thermotoga maritima amidohydrolase tm09362 bound to ni and methionine
67 | c2pajA_ |
| not modelled | 99.1 | 12 | PDB header:hydrolase Chain: A: PDB Molecule:putative cytosine/guanine deaminase; PDBTitle: crystal structure of an amidohydrolase from an environmental sample of2 sargasso sea
68 | c2ogjB_ |
| not modelled | 99.1 | 16 | PDB header:hydrolase Chain: B: PDB Molecule:dihydroorotase; PDBTitle: crystal structure of a dihydroorotase
69 | c2imrA_ |
| not modelled | 99.1 | 10 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein dr_0824; PDBTitle: crystal structure of amidohydrolase dr_0824 from2 deinococcus radiodurans
70 | c2i9uA_ |
| not modelled | 99.1 | 10 | PDB header:hydrolase Chain: A: PDB Molecule:cytosine/guanine deaminase related protein; PDBTitle: crystal structure of guanine deaminase from c. acetobutylicum with2 bound guanine in the active site
71 | d1un7a2 |
| not modelled | 99.1 | 15 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain
72 | c2q09A_ |
| not modelled | 99.1 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: crystal structure of imidazolonepropionase from environmental sample2 with bound inhibitor 3-(2,5-dioxo-imidazolidin-4-yl)-propionic acid
73 | d1ra0a2 |
| not modelled | 99.1 | 14 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Cytosine deaminase catalytic domain
74 | d1itua_ |
| not modelled | 99.1 | 13 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Renal dipeptidase
75 | c2aqoB_ |
| not modelled | 99.0 | 11 | PDB header:hydrolase Chain: B: PDB Molecule:isoaspartyl dipeptidase; PDBTitle: crystal structure of e. coli isoaspartyl dipeptidase mutant e77q
76 | d2ooda2 |
| not modelled | 99.0 | 16 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:SAH/MTA deaminase-like
77 | c2i5gB_ |
| not modelled | 99.0 | 12 | PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase; PDBTitle: crystal strcuture of amidohydrolase from pseudomonas2 aeruginosa
78 | c2bb0A_ |
| not modelled | 99.0 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: structure of imidazolonepropionase from bacillus subtilis
79 | c3lnpA_ |
| not modelled | 99.0 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase family protein olei01672_1_465; PDBTitle: crystal structure of amidohydrolase family protein2 olei01672_1_465 from oleispira antarctica
80 | c3dc8B_ |
| not modelled | 99.0 | 15 | PDB header:hydrolase Chain: B: PDB Molecule:dihydropyrimidinase; PDBTitle: crystal structure of dihydropyrimidinase from sinorhizobium meliloti
81 | c1r9yA_ |
| not modelled | 99.0 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:cytosine deaminase; PDBTitle: bacterial cytosine deaminase d314a mutant.
82 | c3gnhA_ |
| not modelled | 99.0 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:l-lysine, l-arginine carboxypeptidase cc2672; PDBTitle: crystal structure of l-lysine, l-arginine carboxypeptidase cc2672 from2 caulobacter crescentus cb15 complexed with n-methyl phosphonate3 derivative of l-arginine.
83 | c2gokA_ |
| not modelled | 98.9 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: crystal structure of the imidazolonepropionase from agrobacterium2 tumefaciens at 1.87 a resolution
84 | c1gkpD_ |
| not modelled | 98.9 | 17 | PDB header:hydrolase Chain: D: PDB Molecule:hydantoinase; PDBTitle: d-hydantoinase (dihydropyrimidinase) from thermus sp. in2 space group c2221
85 | d2q09a2 |
| not modelled | 98.9 | 14 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Imidazolonepropionase-like
86 | c3b40A_ |
| not modelled | 98.9 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:probable dipeptidase; PDBTitle: crystal structure of the probable dipeptidase pvdm from2 pseudomonas aeruginosa
87 | c1k1dF_ |
| not modelled | 98.9 | 15 | PDB header:hydrolase Chain: F: PDB Molecule:d-hydantoinase; PDBTitle: crystal structure of d-hydantoinase
88 | d2puza2 |
| not modelled | 98.9 | 17 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Imidazolonepropionase-like
89 | c3hm7A_ |
| not modelled | 98.9 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:allantoinase; PDBTitle: crystal structure of allantoinase from bacillus halodurans c-125
90 | c2icsA_ |
| not modelled | 98.9 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:adenine deaminase; PDBTitle: crystal structure of an adenine deaminase
91 | c1gkrA_ |
| not modelled | 98.9 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:non-atp dependent l-selective hydantoinase; PDBTitle: l-hydantoinase (dihydropyrimidinase) from arthrobacter2 aurescens
92 | c3d6nA_ |
| not modelled | 98.8 | 13 | PDB header:hydrolase/transferase Chain: A: PDB Molecule:dihydroorotase; PDBTitle: crystal structure of aquifex dihydroorotase activated by aspartate2 transcarbamoylase
93 | c2vr2A_ |
| not modelled | 98.8 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:dihydropyrimidinase; PDBTitle: human dihydropyrimidinase
94 | c2ftwA_ |
| not modelled | 98.8 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:dihydropyrimidine amidohydrolase; PDBTitle: crystal structure of dihydropyrimidinase from dictyostelium discoideum
95 | c3lsbA_ |
| not modelled | 98.8 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:triazine hydrolase; PDBTitle: crystal structure of the mutant e241q of atrazine chlorohydrolase trzn2 from arthrobacter aurescens tc1 complexed with zinc and ametrin
96 | d1o12a2 |
| not modelled | 98.8 | 14 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain
97 | c1nfgA_ |
| not modelled | 98.8 | 8 | PDB header:hydrolase Chain: A: PDB Molecule:d-hydantoinase; PDBTitle: structure of d-hydantoinase
98 | d4ubpc2 |
| not modelled | 98.8 | 15 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:alpha-subunit of urease, catalytic domain
99 | c2gseC_ |
| not modelled | 98.8 | 12 | PDB header:hydrolase Chain: C: PDB Molecule:dihydropyrimidinase-related protein 2; PDBTitle: crystal structure of human dihydropyrimidinease-like 2
100 | c2p50C_ |
| not modelled | 98.7 | 11 | PDB header:hydrolase Chain: C: PDB Molecule:n-acetylglucosamine-6-phosphate deacetylase; PDBTitle: crystal structure of n-acetyl-d-glucosamine-6-phosphate deacetylase2 liganded with zn
101 | c3ighX_ |
| not modelled | 98.7 | 22 | PDB header:hydrolase Chain: X: PDB Molecule:uncharacterized metal-dependent hydrolase; PDBTitle: crystal structure of an uncharacterized metal-dependent2 hydrolase from pyrococcus horikoshii ot3
102 | c3etkA_ |
| not modelled | 98.7 | 22 | PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized metal-dependent hydrolase; PDBTitle: crystal structure of an uncharacterized metal-dependent2 hydrolase from pyrococcus furiosus
103 | c2qt3A_ |
| not modelled | 98.7 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:n-isopropylammelide isopropyl amidohydrolase; PDBTitle: crystal structure of n-isopropylammelide isopropylaminohydrolase atzc2 from pseudomonas sp. strain adp complexed with zn
104 | c3mduA_ |
| not modelled | 98.7 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:n-formimino-l-glutamate iminohydrolase; PDBTitle: the structure of n-formimino-l-glutamate iminohydrolase from2 pseudomonas aeruginosa complexed with n-guanidino-l-glutamate
105 | c2fvmA_ |
| not modelled | 98.7 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:dihydropyrimidinase; PDBTitle: crystal structure of dihydropyrimidinase from saccharomyces kluyveri2 in complex with the reaction product n-carbamyl-beta-alanine
106 | c3fdgA_ |
| not modelled | 98.6 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:dipeptidase ac. metallo peptidase. merops family m19; PDBTitle: the crystal structure of the dipeptidase ac, metallo peptidase. merops2 family m19
107 | c2oodA_ |
| not modelled | 98.6 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:blr3880 protein; PDBTitle: crystal structure of guanine deaminase from bradyrhizobium japonicum
108 | c3itcA_ |
| not modelled | 98.5 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:renal dipeptidase; PDBTitle: crystal structure of sco3058 with bound citrate and glycerol
109 | c2ragB_ |
| not modelled | 98.5 | 11 | PDB header:hydrolase Chain: B: PDB Molecule:dipeptidase; PDBTitle: crystal structure of aminohydrolase from caulobacter crescentus
110 | c3lu2B_ |
| not modelled | 98.5 | 13 | PDB header:hydrolase Chain: B: PDB Molecule:lmo2462 protein; PDBTitle: structure of lmo2462, a listeria monocytogenes amidohydrolase family2 putative dipeptidase
111 | c2z00A_ |
| not modelled | 98.5 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:dihydroorotase; PDBTitle: crystal structure of dihydroorotase from thermus thermophilus
112 | c3be7B_ |
| not modelled | 98.5 | 20 | PDB header:hydrolase Chain: B: PDB Molecule:zn-dependent arginine carboxypeptidase; PDBTitle: crystal structure of zn-dependent arginine carboxypeptidase
113 | c2p9bA_ |
| not modelled | 98.5 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:possible prolidase; PDBTitle: crystal structure of putative prolidase from2 bifidobacterium longum
114 | c3mpgB_ |
| not modelled | 98.4 | 15 | PDB header:hydrolase Chain: B: PDB Molecule:dihydroorotase; PDBTitle: dihydroorotase from bacillus anthracis
115 | d1m7ja3 |
| not modelled | 98.4 | 16 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:D-aminoacylase, catalytic domain
116 | c3griB_ |
| not modelled | 98.4 | 10 | PDB header:hydrolase Chain: B: PDB Molecule:dihydroorotase; PDBTitle: the crystal structure of a dihydroorotase from staphylococcus aureus
117 | c3e74D_ |
| not modelled | 98.3 | 13 | PDB header:hydrolase Chain: D: PDB Molecule:allantoinase; PDBTitle: crystal structure of e. coli allantoinase with iron ions at2 the metal center
118 | c2qs8A_ |
| not modelled | 98.3 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal structure of a xaa-pro dipeptidase with bound2 methionine in the active site
119 | c3la4A_ |
| not modelled | 98.3 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:urease; PDBTitle: crystal structure of the first plant urease from jack bean (canavalia2 ensiformis)
120 | d1j5sa_ |
| not modelled | 98.3 | 18 | Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:Uronate isomerase-like

Binding site prediction |

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If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0