Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	D	Q	I	I	A	R	V	S	Q	S	L	A	K	E	Q	S	L	E	S	L	V	R	Q	L	L	E	M	L	E	M	V	T	D	M	E	S	T	Y	L	T	K	V	D	V	E	A	R	L	Q	H	I	M	F	A	R	N	S	Q
Secondary structure
SS confidence
Disorder		?	?													?	?	?	?																																								?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	M	Y	I	P	E	N	F	T	V	S	W	D	Y	S	L	C	K	R	A	I	D	E	N	C	F	F	S	D	E	V	P	D	R	W	G	D	C	I	A	A	R	N	L	G	I	T	T	F	L	S	T	P	I	H	L	P	D	G	S
Secondary structure
SS confidence
Disorder		?	?	?	?	?				?																							?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	Y	G	T	L	C	A	A	S	S	E	K	R	Q	W	S	E	R	A	E	Q	V	L	Q	L	F	A	G	L	I	A	Q	Y	I	Q	K	E	A	L	V	E	Q	L	R	E	A	N	A	A	L	I	A	Q	S	Y	T	D	S	L	T
Secondary structure
SS confidence
Disorder													?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	L	P	N	R	R	A	I	F	E	N	L	T	T	L	F	S	L	A	R	H	L	N	H	K	I	M	I	A	F	I	D	L	D	N	F	K	L	I	N	D	R	F	G	H	N	S	G	D	L	F	L	I	Q	V	G	E	R	L	N
Secondary structure
SS confidence
Disorder																						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	L	Q	Q	N	G	E	V	I	G	R	L	G	G	D	E	F	L	V	V	S	L	N	N	E	N	A	D	I	S	S	L	R	E	R	I	Q	Q	Q	I	R	G	E	Y	H	L	G	D	V	D	L	Y	Y	P	G	A	S	L	G	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.
Sequence		V	E	V	D	P	E	T	T	D	A	D	S	A	L	H	A	A	D	I	A	M	Y	Q	E	K	K	H	K	Q	K	T	P	F	V	A	H	P	A	L	H	S
Secondary structure
SS confidence
Disorder																																									?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1w25 chain B Region: 150 - 337 Aligned: 188 Modelled: 188 Confidence: 100.0% Identity: 28% PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp Phyre2 PDB 3ezu chain A Region: 161 - 334 Aligned: 165 Modelled: 174 Confidence: 100.0% Identity: 28% PDB header:signaling protein Chain: A: PDB Molecule:ggdef domain protein; PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution Phyre2 PDB 3bre chain A Region: 161 - 336 Aligned: 176 Modelled: 176 Confidence: 100.0% Identity: 27% PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: crystal structure of p.aeruginosa pa3702 Phyre2 PDB 3icl chain A Region: 176 - 337 Aligned: 162 Modelled: 161 Confidence: 100.0% Identity: 26% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:eal/ggdef domain protein; PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium3 target mcr174c Phyre2 PDB 3ign chain A Region: 172 - 335 Aligned: 164 Modelled: 160 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase; PDBTitle: crystal structure of the ggdef domain from marinobacter2 aquaeolei diguanylate cyclase complexed with c-di-gmp -3 northeast structural genomics consortium target mqr89a Phyre2 PDB 3i5a chain A Region: 167 - 333 Aligned: 167 Modelled: 167 Confidence: 100.0% Identity: 28% PDB header:signaling protein Chain: A: PDB Molecule:response regulator/ggdef domain protein; PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae Phyre2 PDB 3hva chain A Region: 173 - 333 Aligned: 161 Modelled: 161 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:protein fimx; PDBTitle: crystal structure of fimx ggdef domain from pseudomonas2 aeruginosa Phyre2 PDB 3i5b chain A Region: 173 - 336 Aligned: 164 Modelled: 164 Confidence: 100.0% Identity: 24% PDB header:signaling protein Chain: A: PDB Molecule:wspr response regulator; PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa Phyre2 PDB 1w25 chain A domain 3 Region: 179 - 337 Aligned: 159 Modelled: 159 Confidence: 100.0% Identity: 30% Fold: Ferredoxin-like Superfamily: Nucleotide cyclase Family: GGDEF domain Phyre2 PDB 3i5c chain A Region: 162 - 334 Aligned: 173 Modelled: 173 Confidence: 100.0% Identity: 27% PDB header:signaling protein Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa Phyre2 PDB 3mtk chain A Region: 169 - 340 Aligned: 162 Modelled: 172 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase; PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c Phyre2 PDB 3qyy chain B Region: 169 - 334 Aligned: 155 Modelled: 155 Confidence: 100.0% Identity: 29% PDB header:signaling protein/inhibitor Chain: B: PDB Molecule:response regulator; PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp Phyre2 PDB 3hvw chain A Region: 183 - 341 Aligned: 155 Modelled: 159 Confidence: 100.0% Identity: 13% PDB header:lyase Chain: A: PDB Molecule:diguanylate-cyclase (dgc); PDBTitle: crystal structure of the ggdef domain of the pa2567 protein2 from pseudomonas aeruginosa, northeast structural genomics3 consortium target par365c Phyre2 PDB 3pjw chain A Region: 157 - 340 Aligned: 181 Modelled: 184 Confidence: 100.0% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23 Phyre2 PDB 3gfz chain B Region: 170 - 341 Aligned: 142 Modelled: 144 Confidence: 99.7% Identity: 10% PDB header:hydrolase, signaling protein Chain: B: PDB Molecule:klebsiella pneumoniae blrp1; PDBTitle: klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex Phyre2 PDB 3ci6 chain B Region: 4 - 164 Aligned: 160 Modelled: 161 Confidence: 99.1% Identity: 11% PDB header:transferase Chain: B: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: crystal structure of the gaf domain from acinetobacter2 phosphoenolpyruvate-protein phosphotransferase Phyre2 PDB 3trc chain A Region: 4 - 163 Aligned: 159 Modelled: 160 Confidence: 99.0% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of the gaf domain from a phosphoenolpyruvate-protein2 phosphotransferase (ptsp) from coxiella burnetii Phyre2 PDB 2o9c chain A domain 1 Region: 4 - 159 Aligned: 155 Modelled: 156 Confidence: 99.0% Identity: 16% Fold: Profilin-like Superfamily: GAF domain-like Family: GAF domain Phyre2 PDB 3k2n chain B Region: 4 - 167 Aligned: 163 Modelled: 164 Confidence: 99.0% Identity: 18% PDB header:transcription regulator Chain: B: PDB Molecule:sigma-54-dependent transcriptional regulator; PDBTitle: the crystal structure of sigma-54-dependent transcriptional2 regulator domain from chlorobium tepidum tls Phyre2 PDB 3mmh chain A Region: 3 - 158 Aligned: 149 Modelled: 151 Confidence: 98.9% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:methionine-r-sulfoxide reductase; PDBTitle: x-ray structure of free methionine-r-sulfoxide reductase from2 neisseria meningitidis in complex with its substrate Phyre2 PDB 2zmf chain A Region: 3 - 164 Aligned: 162 Modelled: 157 Confidence: 98.9% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:camp and camp-inhibited cgmp 3',5'-cyclic phosphodiesterase PDBTitle: crystal structure of the c-terminal gaf domain of human2 phosphodiesterase 10a Phyre2 1 c1w25B_ 2 c3ezuA_ 3 c3breA_ 4 c3iclA_ 5 c3ignA_ 6 c3i5aA_ 7 c3hvaA_ 8 c3i5bA_ 9 d1w25a3 10 c3i5cA_ 11 c3mtkA_ 12 c3qyyB_ 13 c3hvwA_ 14 c3pjwA_ 15 c3gfzB_ 16 c3ci6B_ 17 c3trcA_ 18 d2o9ca1 19 c3k2nB_ 20 c3mmhA_ 21 c2zmfA_ 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1w25B_ 100.0 28 PDB header:signaling protein Chain: B: PDB Molecule:stalked-cell differentiation controlling protein; PDBTitle: response regulator pled in complex with c-digmp 2 c3ezuA_ 100.0 28 PDB header:signaling protein Chain: A: PDB Molecule:ggdef domain protein; PDBTitle: crystal structure of multidomain protein of unknown function with2 ggdef-domain (np_951600.1) from geobacter sulfurreducens at 1.95 a3 resolution 3 c3breA_ 100.0 27 PDB header:signaling protein Chain: A: PDB Molecule:probable two-component response regulator; PDBTitle: crystal structure of p.aeruginosa pa3702 4 c3iclA_ 100.0 26 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:eal/ggdef domain protein; PDBTitle: x-ray structure of protein (eal/ggdef domain protein) from2 m.capsulatus, northeast structural genomics consortium3 target mcr174c 5 c3ignA_ 100.0 24 PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase; PDBTitle: crystal structure of the ggdef domain from marinobacter2 aquaeolei diguanylate cyclase complexed with c-di-gmp -3 northeast structural genomics consortium target mqr89a 6 c3i5aA_ 100.0 28 PDB header:signaling protein Chain: A: PDB Molecule:response regulator/ggdef domain protein; PDBTitle: crystal structure of full-length wpsr from pseudomonas syringae 7 c3hvaA_ 100.0 16 PDB header:transferase Chain: A: PDB Molecule:protein fimx; PDBTitle: crystal structure of fimx ggdef domain from pseudomonas2 aeruginosa 8 c3i5bA_ 100.0 24 PDB header:signaling protein Chain: A: PDB Molecule:wspr response regulator; PDBTitle: crystal structure of the isolated ggdef domain of wpsr from2 pseudomonas aeruginosa 9 d1w25a3 100.0 30 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:GGDEF domain 10 c3i5cA_ 100.0 27 PDB header:signaling protein Chain: A: PDB Molecule:fusion of general control protein gcn4 and wspr response PDBTitle: crystal structure of a fusion protein containing the leucine zipper of2 gcn4 and the ggdef domain of wspr from pseudomonas aeruginosa 11 c3mtkA_ 100.0 21 PDB header:transferase Chain: A: PDB Molecule:diguanylate cyclase/phosphodiesterase; PDBTitle: x-ray structure of diguanylate cyclase/phosphodiesterase from2 caldicellulosiruptor saccharolyticus, northeast structural genomics3 consortium target clr27c 12 c3qyyB_ 100.0 29 PDB header:signaling protein/inhibitor Chain: B: PDB Molecule:response regulator; PDBTitle: a novel interaction mode between a microbial ggdef domain and the bis-2 (3, 5 )-cyclic di-gmp 13 c3hvwA_ 100.0 13 PDB header:lyase Chain: A: PDB Molecule:diguanylate-cyclase (dgc); PDBTitle: crystal structure of the ggdef domain of the pa2567 protein2 from pseudomonas aeruginosa, northeast structural genomics3 consortium target par365c 14 c3pjwA_ 100.0 22 PDB header:lyase Chain: A: PDB Molecule:cyclic dimeric gmp binding protein; PDBTitle: structure of pseudomonas fluorescence lapd ggdef-eal dual domain, i23 15 c3gfzB_ 99.7 10 PDB header:hydrolase, signaling protein Chain: B: PDB Molecule:klebsiella pneumoniae blrp1; PDBTitle: klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex 16 c3ci6B_ 99.1 11 PDB header:transferase Chain: B: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: crystal structure of the gaf domain from acinetobacter2 phosphoenolpyruvate-protein phosphotransferase 17 c3trcA_ 99.0 14 PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of the gaf domain from a phosphoenolpyruvate-protein2 phosphotransferase (ptsp) from coxiella burnetii 18 d2o9ca1 99.0 16 Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain 19 c3k2nB_ 99.0 18 PDB header:transcription regulator Chain: B: PDB Molecule:sigma-54-dependent transcriptional regulator; PDBTitle: the crystal structure of sigma-54-dependent transcriptional2 regulator domain from chlorobium tepidum tls 20 c3mmhA_ 98.9 14 PDB header:oxidoreductase Chain: A: PDB Molecule:methionine-r-sulfoxide reductase; PDBTitle: x-ray structure of free methionine-r-sulfoxide reductase from2 neisseria meningitidis in complex with its substrate 21 c2zmfA_ 98.9 11 PDB header:hydrolase Chain: A: PDB Molecule:camp and camp-inhibited cgmp 3',5'-cyclic phosphodiesterase PDBTitle: crystal structure of the c-terminal gaf domain of human2 phosphodiesterase 10a 22 d2veaa1 not modelled 98.9 14 Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain 23 c3p7nB_ not modelled 98.9 13 PDB header:dna binding protein Chain: B: PDB Molecule:sensor histidine kinase; PDBTitle: crystal structure of light activated transcription factor el222 from2 erythrobacter litoralis 24 d2oola1 not modelled 98.8 16 Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain 25 c3oovA_ not modelled 98.8 13 PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein, putative; PDBTitle: crystal structure of a methyl-accepting chemotaxis protein, residues2 122 to 287 26 c3p01C_ not modelled 98.7 12 PDB header:signaling protein Chain: C: PDB Molecule:two-component response regulator; PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120 27 c3o5yA_ not modelled 98.7 14 PDB header:transcription regulator Chain: A: PDB Molecule:sensor protein; PDBTitle: the crystal structure of the gaf domain of a two-component sensor2 histidine kinase from bacillus halodurans to 2.45a 28 c2qybA_ not modelled 98.7 16 PDB header:membrane protein Chain: A: PDB Molecule:membrane protein, putative; PDBTitle: crystal structure of the gaf domain region of putative membrane2 protein from geobacter sulfurreducens pca 29 c3p01A_ not modelled 98.7 11 PDB header:signaling protein Chain: A: PDB Molecule:two-component response regulator; PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120 30 d3c2wa1 not modelled 98.6 15 Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain 31 c1vhmB_ not modelled 98.6 12 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein yebr; PDBTitle: crystal structure of an hypothetical protein 32 c3eeaB_ not modelled 98.6 10 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:gaf domain/hd domain protein; PDBTitle: the crystal structure of the gaf domain/hd domain protein2 from geobacter sulfurreducens 33 c3ibjB_ not modelled 98.6 11 PDB header:hydrolase Chain: B: PDB Molecule:cgmp-dependent 3',5'-cyclic phosphodiesterase; PDBTitle: x-ray structure of pde2a 34 d1vhma_ not modelled 98.5 12 Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain 35 c1mc0A_ not modelled 98.5 9 PDB header:hydrolase Chain: A: PDB Molecule:3',5'-cyclic nucleotide phosphodiesterase 2a; PDBTitle: regulatory segment of mouse 3',5'-cyclic nucleotide phosphodiesterase2 2a, containing the gaf a and gaf b domains 36 d1mc0a1 not modelled 98.5 12 Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain 37 c3hcyB_ not modelled 98.5 11 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative two-component sensor histidine kinase protein; PDBTitle: the crystal structure of the domain of putative two-component sensor2 histidine kinase protein from sinorhizobium meliloti 1021 38 c2vjwA_ not modelled 98.5 13 PDB header:hydrolase Chain: A: PDB Molecule:gaf family protein; PDBTitle: crystal structure of the second gaf domain of devs from2 mycobacterium smegmatis 39 c3ksiA_ not modelled 98.4 10 PDB header:oxidoreductase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of frmsr of staphylococcus aureus (complex with 2-propanol) 40 c3e0yA_ not modelled 98.4 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved domain protein; PDBTitle: the crystal structure of a conserved domain from a protein of2 geobacter sulfurreducens pca 41 c3dbaB_ not modelled 98.4 11 PDB header:hydrolase Chain: B: PDB Molecule:cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit PDBTitle: crystal structure of the cgmp-bound gaf a domain from the2 photoreceptor phosphodiesterase 6c 42 c2w3gA_ not modelled 98.3 14 PDB header:transferase Chain: A: PDB Molecule:two component sensor histidine kinase devs (gaf PDBTitle: air-oxidized structure of the first gaf domain of2 mycobacterium tuberculosis doss 43 d2k2na1 not modelled 98.3 19 Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain 44 c2lb5A_ not modelled 98.3 16 PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: refined structural basis for the photoconversion of a phytochrome to2 the activated far-red light-absorbing form 45 d1mc0a2 not modelled 98.2 10 Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain 46 c3mf0A_ not modelled 98.2 8 PDB header:hydrolase Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase; PDBTitle: crystal structure of pde5a gaf domain (89-518) 47 c1ykdB_ not modelled 98.2 10 PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of the tandem gaf domains from a cyanobacterial2 adenylyl cyclase: novel modes of ligand-binding and dimerization 48 c3e98B_ not modelled 98.1 12 PDB header:unknown function Chain: B: PDB Molecule:gaf domain of unknown function; PDBTitle: crystal structure of a gaf domain containing protein that belongs to2 pfam duf484 family (pa5279) from pseudomonas aeruginosa at 2.43 a3 resolution 49 c2oolA_ not modelled 98.1 16 PDB header:signaling protein Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of the chromophore-binding domain of an unusual2 bacteriophytochrome rpbphp3 from r. palustris 50 c3c2wB_ not modelled 98.0 13 PDB header:signaling protein Chain: B: PDB Molecule:bacteriophytochrome; PDBTitle: crystal structure of the photosensory core domain of p.2 aeruginosa bacteriophytochrome pabphp in the pfr state 51 c2k31A_ not modelled 98.0 11 PDB header:hydrolase Chain: A: PDB Molecule:phosphodiesterase 5a, cgmp-specific; PDBTitle: solution structure of cgmp-binding gaf domain of2 phosphodiesterase 5 52 c2o9bA_ not modelled 97.9 16 PDB header:transferase Chain: A: PDB Molecule:bacteriophytochrome; PDBTitle: crystal structure of bacteriophytochrome chromophore binding domain 53 c2qv6D_ not modelled 97.7 21 PDB header:hydrolase Chain: D: PDB Molecule:gtp cyclohydrolase iii; PDBTitle: gtp cyclohydrolase iii from m. jannaschii (mj0145)2 complexed with gtp and metal ions 54 d1f5ma_ not modelled 97.5 10 Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain 55 c2veaA_ not modelled 97.5 13 PDB header:transferase Chain: A: PDB Molecule:phytochrome-like protein cph1; PDBTitle: the complete sensory module of the cyanobacterial2 phytochrome cph1 in the pr-state. 56 c2xssB_ not modelled 97.2 10 PDB header:hydrolase Chain: B: PDB Molecule:cgmp-specific 3', 5'-cyclic phosphodiesterase; PDBTitle: crystal structure of gafb from the human phosphodiesterase 5 57 d1azsa_ not modelled 89.9 15 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 58 d1fx2a_ not modelled 89.0 12 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 59 c2aq4A_ not modelled 87.3 21 PDB header:transferase Chain: A: PDB Molecule:dna repair protein rev1; PDBTitle: ternary complex of the catalytic core of rev1 with dna and dctp. 60 c1cjkA_ not modelled 86.4 17 PDB header:lyase/lyase/signaling protein Chain: A: PDB Molecule:adenylate cyclase, type v; PDBTitle: complex of gs-alpha with the catalytic domains of mammalian adenylyl2 cyclase: complex with adenosine 5'-(alpha thio)-triphosphate (rp),3 mg, and mn 61 c1ybuA_ not modelled 84.9 16 PDB header:hydrolase Chain: A: PDB Molecule:lipj; PDBTitle: mycobacterium tuberculosis adenylyl cyclase rv1900c chd, in complex2 with a substrate analog. 62 d1fx4a_ not modelled 84.2 16 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 63 c1wc6B_ not modelled 84.2 17 PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: soluble adenylyl cyclase cyac from s. platensis in complex2 with rp-atpalphas in presence of bicarbonate 64 d1wc1a_ not modelled 83.6 16 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 65 c3mr7B_ not modelled 81.1 16 PDB header:hydrolase Chain: B: PDB Molecule:adenylate/guanylate cyclase/hydrolase, alpha/beta fold PDBTitle: crystal structure of adenylate/guanylate cyclase/hydrolase from2 silicibacter pomeroyi 66 c3et6A_ not modelled 80.9 11 PDB header:lyase Chain: A: PDB Molecule:soluble guanylyl cyclase beta; PDBTitle: the crystal structure of the catalytic domain of a eukaryotic2 guanylate cyclase 67 c2w01C_ not modelled 76.5 16 PDB header:lyase Chain: C: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of the guanylyl cyclase cya2 68 c1yk9A_ not modelled 72.7 13 PDB header:lyase Chain: A: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of a mutant form of the mycobacterial2 adenylyl cyclase rv1625c 69 c3gqcB_ not modelled 71.8 21 PDB header:transferase/dna Chain: B: PDB Molecule:dna repair protein rev1; PDBTitle: structure of human rev1-dna-dntp ternary complex 70 c1y10C_ not modelled 71.4 11 PDB header:lyase Chain: C: PDB Molecule:hypothetical protein rv1264/mt1302; PDBTitle: mycobacterial adenylyl cyclase rv1264, holoenzyme, inhibited state 71 c3uvjC_ not modelled 69.0 14 PDB header:lyase Chain: C: PDB Molecule:guanylate cyclase soluble subunit alpha-3; PDBTitle: crystal structure of the catalytic domain of the heterodimeric human2 soluble guanylate cyclase 1. 72 c2gx5B_ not modelled 65.9 11 PDB header:transcription Chain: B: PDB Molecule:gtp-sensing transcriptional pleiotropic repressor cody; PDBTitle: n-terminal gaf domain of transcriptional pleiotropic repressor cody 73 c1s97D_ not modelled 61.6 17 PDB header:transferase/dna Chain: D: PDB Molecule:dna polymerase iv; PDBTitle: dpo4 with gt mismatch 74 c3onqB_ not modelled 58.5 10 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:regulator of polyketide synthase expression; PDBTitle: crystal structure of regulator of polyketide synthase expression2 bad_0249 from bifidobacterium adolescentis 75 c1k1qA_ not modelled 51.4 20 PDB header:transcription Chain: A: PDB Molecule:dbh protein; PDBTitle: crystal structure of a dinb family error prone dna2 polymerase from sulfolobus solfataricus 76 c3r5gB_ not modelled 50.7 12 PDB header:lyase Chain: B: PDB Molecule:cyab; PDBTitle: crystal structure of the adenylyl cyclase cyab from p. aeruginosa 77 c2r8kB_ not modelled 50.2 29 PDB header:replication, transferase/dna Chain: B: PDB Molecule:dna polymerase eta; PDBTitle: structure of the eukaryotic dna polymerase eta in complex with 1,2-2 d(gpg)-cisplatin containing dna 78 c3cloC_ not modelled 49.2 12 PDB header:transcription regulator Chain: C: PDB Molecule:transcriptional regulator; PDBTitle: crystal structure of putative transcriptional regulator containing a2 luxr dna binding domain (np_811094.1) from bacteroides3 thetaiotaomicron vpi-5482 at 2.04 a resolution 79 c1jihA_ not modelled 47.0 29 PDB header:translation Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: yeast dna polymerase eta 80 d1l3la2 not modelled 40.3 15 Fold:Profilin-like Superfamily:Pheromone-binding domain of LuxR-like quorum-sensing transcription factors Family:Pheromone-binding domain of LuxR-like quorum-sensing transcription factors 81 c3bwlA_ not modelled 39.7 9 PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of pas domain of htr-like protein from haloarcula2 marismortui 82 c3mfxA_ not modelled 35.0 7 PDB header:transcription Chain: A: PDB Molecule:sensory box/ggdef family protein; PDBTitle: crystal structure of the sensory box domain of the sensory-2 box/ggdef protein so_1695 from shewanella oneidensis,3 northeast structural genomics consortium target sor288b 83 c3mxqC_ not modelled 35.0 13 PDB header:transferase Chain: C: PDB Molecule:sensor protein; PDBTitle: crystal structure of sensory box sensor histidine kinase from vibrio2 cholerae 84 d1jx4a2 not modelled 33.0 15 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 85 c2wz1B_ not modelled 31.7 14 PDB header:lyase Chain: B: PDB Molecule:guanylate cyclase soluble subunit beta-1; PDBTitle: structure of the catalytic domain of human soluble2 guanylate cyclase 1 beta 3. 86 c2oh2B_ not modelled 31.6 21 PDB header:transferase/dna Chain: B: PDB Molecule:dna polymerase kappa; PDBTitle: ternary complex of human dna polymerase 87 d1im4a_ not modelled 30.0 20 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 88 c2qkpD_ not modelled 30.0 12 PDB header:structural genomics, unknown function Chain: D: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of c-terminal domain of smu_1151c from streptococcus2 mutans 89 c2w0nA_ not modelled 28.7 10 PDB header:transferase Chain: A: PDB Molecule:sensor protein dcus; PDBTitle: plasticity of pas domain and potential role for signal2 transduction in the histidine-kinase dcus 90 c3mr2A_ not modelled 28.5 25 PDB header:transferase/dna Chain: A: PDB Molecule:dna polymerase eta; PDBTitle: human dna polymerase eta in complex with normal dna and incoming2 nucleotide (nrm) 91 d1ew0a_ not modelled 26.5 17 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Heme-binding PAS domain 92 c2w1rA_ not modelled 24.9 12 PDB header:transcription Chain: A: PDB Molecule:stage v sporulation protein t; PDBTitle: crystal structure of the c-terminal domain of b. subtilis2 spovt 93 d1jiha2 not modelled 23.9 20 Fold:DNA/RNA polymerases Superfamily:DNA/RNA polymerases Family:Lesion bypass DNA polymerase (Y-family), catalytic domain 94 d1t0aa_ not modelled 23.5 13 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 95 c3lyxA_ not modelled 22.8 12 PDB header:transcription Chain: A: PDB Molecule:sensory box/ggdef domain protein; PDBTitle: crystal structure of the pas domain of the protein cps_12912 from colwellia psychrerythraea. northeast structural3 genomics consortium target id csr222b 96 c3oloB_ not modelled 21.2 9 PDB header:transferase Chain: B: PDB Molecule:two-component sensor histidine kinase; PDBTitle: crystal structure of a pas domain from two-component sensor histidine2 kinase 97 d1azsb_ not modelled 21.1 11 Fold:Ferredoxin-like Superfamily:Nucleotide cyclase Family:Adenylyl and guanylyl cyclase catalytic domain 98 d1w55a2 not modelled 20.8 9 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 99 d1iv3a_ not modelled 18.6 14 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0