Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	Q	N	I	R	I	V	L	V	E	T	S	H	T	G	N	M	G	S	V	A	R	A	M	K	T	M	G	L	T	N	L	W	L	V	N	P	L	V	K	P	D	S	Q	A	I	A	L	A	A	G	A	S	D	V	I	G	N	A
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	I	V	D	T	L	D	E	A	L	A	G	C	S	L	V	V	G	T	S	A	R	S	R	T	L	P	W	P	M	L	D	P	R	E	C	G	L	K	S	V	A	E	A	A	N	T	P	V	A	L	V	F	G	R	E	R	V	G	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	N	E	E	L	Q	K	C	H	Y	H	V	A	I	A	A	N	P	E	Y	S	S	L	N	L	A	M	A	V	Q	V	I	A	Y	E	V	R	M	A	W	L	A	T	Q	E	N	G	E	Q	V	E	H	E	E	T	P	Y	P	L	V
Secondary structure
SS confidence
Disorder																																									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	D	L	E	R	F	Y	G	H	L	E	Q	T	L	L	A	T	G	F	I	R	E	N	H	P	G	Q	V	M	N	K	L	R	R	L	F	T	R	A	R	P	E	S	Q	E	L	N	I	L	R	G	I	L	A	S	I	E	Q	Q	N
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.	.	.	.
Sequence		K	G	N	K	A	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3ilk chain B Region: 1 - 244 Aligned: 233 Modelled: 226 Confidence: 100.0% Identity: 54% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized trna/rrna methyltransferase hi0380; PDBTitle: the structure of a probable methylase family protein from haemophilus2 influenzae rd kw20 Phyre2 PDB 3ic6 chain A Region: 2 - 193 Aligned: 185 Modelled: 191 Confidence: 100.0% Identity: 41% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative methylase family protein; PDBTitle: crystal structure of putative methylase family protein from neisseria2 gonorrhoeae Phyre2 PDB 3onp chain A Region: 4 - 159 Aligned: 156 Modelled: 151 Confidence: 100.0% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:trna/rrna methyltransferase (spou); PDBTitle: crystal structure of trna/rrna methyltransferase spou from rhodobacter2 sphaeroides Phyre2 PDB 1zjr chain A Region: 3 - 190 Aligned: 172 Modelled: 172 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:trna (guanosine-2'-o-)-methyltransferase; PDBTitle: crystal structure of a. aeolicus trmh/spou trna modifying enzyme Phyre2 PDB 3kty chain A Region: 2 - 161 Aligned: 157 Modelled: 155 Confidence: 100.0% Identity: 41% PDB header:transferase Chain: A: PDB Molecule:probable methyltransferase; PDBTitle: crystal structure of probable methyltransferase from bordetella2 pertussis tohama i Phyre2 PDB 1v2x chain A Region: 3 - 190 Aligned: 171 Modelled: 171 Confidence: 100.0% Identity: 19% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 2ha8 chain A Region: 3 - 161 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 17% PDB header:rna binding protein Chain: A: PDB Molecule:tar (hiv-1) rna loop binding protein; PDBTitle: methyltransferase domain of human tar (hiv-1) rna binding2 protein 1 Phyre2 PDB 1gz0 chain A domain 1 Region: 3 - 160 Aligned: 148 Modelled: 158 Confidence: 100.0% Identity: 19% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 1gz0 chain G Region: 3 - 160 Aligned: 148 Modelled: 148 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: G: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb Phyre2 PDB 1ipa chain A Region: 3 - 161 Aligned: 148 Modelled: 148 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:rna 2'-o-ribose methyltransferase; PDBTitle: crystal structure of rna 2'-o ribose methyltransferase Phyre2 PDB 3dcm chain X Region: 1 - 157 Aligned: 156 Modelled: 156 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: X: PDB Molecule:uncharacterized protein tm_1570; PDBTitle: crystal structure of the thermotoga maritima spout family2 rna-methyltransferase protein tm1570 in complex with s-3 adenosyl-l-methionine Phyre2 PDB 1x7p chain B Region: 3 - 163 Aligned: 154 Modelled: 154 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:rrna methyltransferase; PDBTitle: crystal structure of the spou methyltransferase avirb from2 streptomyces viridochromogenes in complex with the cofactor adomet Phyre2 PDB 1ipa chain A domain 1 Region: 3 - 161 Aligned: 148 Modelled: 148 Confidence: 100.0% Identity: 21% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 2i6d chain A Region: 3 - 159 Aligned: 148 Modelled: 147 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:rna methyltransferase, trmh family; PDBTitle: the structure of a putative rna methyltransferase of the trmh family2 from porphyromonas gingivalis. Phyre2 PDB 1mxi chain A Region: 5 - 160 Aligned: 145 Modelled: 155 Confidence: 100.0% Identity: 18% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: SpoU-like RNA 2'-O ribose methyltransferase Phyre2 PDB 3gyq chain B Region: 3 - 163 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:rrna (adenosine-2'-o-)-methyltransferase; PDBTitle: structure of the thiostrepton-resistance methyltransferase2 s-adenosyl-l-methionine complex Phyre2 PDB 3l8u chain A Region: 2 - 160 Aligned: 141 Modelled: 141 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:putative rrna methylase; PDBTitle: crystal structure of smu.1707c, a putative rrna methyltransferase from2 streptococcus mutans ua159 Phyre2 PDB 3e5y chain B Region: 5 - 160 Aligned: 132 Modelled: 132 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:trmh family rna methyltransferase; PDBTitle: crystal structure of trmh family rna methyltransferase from2 burkholderia pseudomallei Phyre2 PDB 1vhk chain A Region: 4 - 156 Aligned: 142 Modelled: 153 Confidence: 95.7% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein yqeu; PDBTitle: crystal structure of an hypothetical protein Phyre2 PDB 1vhk chain A domain 2 Region: 4 - 157 Aligned: 143 Modelled: 154 Confidence: 95.2% Identity: 11% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: YggJ C-terminal domain-like Phyre2 1 c3ilkB_ 2 c3ic6A_ 3 c3onpA_ 4 c1zjrA_ 5 c3ktyA_ 6 d1v2xa_ 7 c2ha8A_ 8 d1gz0a1 9 c1gz0G_ 10 c1ipaA_ 11 c3dcmX_ 12 c1x7pB_ 13 d1ipaa1 14 c2i6dA_ 15 d1mxia_ 16 c3gyqB_ 17 c3l8uA_ 18 c3e5yB_ 19 c1vhkA_ 20 d1vhka2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3ilkB_ 100.0 54 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized trna/rrna methyltransferase hi0380; PDBTitle: the structure of a probable methylase family protein from haemophilus2 influenzae rd kw20 2 c3ic6A_ 100.0 41 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative methylase family protein; PDBTitle: crystal structure of putative methylase family protein from neisseria2 gonorrhoeae 3 c3onpA_ 100.0 35 PDB header:transferase Chain: A: PDB Molecule:trna/rrna methyltransferase (spou); PDBTitle: crystal structure of trna/rrna methyltransferase spou from rhodobacter2 sphaeroides 4 c1zjrA_ 100.0 16 PDB header:transferase Chain: A: PDB Molecule:trna (guanosine-2'-o-)-methyltransferase; PDBTitle: crystal structure of a. aeolicus trmh/spou trna modifying enzyme 5 c3ktyA_ 100.0 41 PDB header:transferase Chain: A: PDB Molecule:probable methyltransferase; PDBTitle: crystal structure of probable methyltransferase from bordetella2 pertussis tohama i 6 d1v2xa_ 100.0 19 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:SpoU-like RNA 2'-O ribose methyltransferase 7 c2ha8A_ 100.0 17 PDB header:rna binding protein Chain: A: PDB Molecule:tar (hiv-1) rna loop binding protein; PDBTitle: methyltransferase domain of human tar (hiv-1) rna binding2 protein 1 8 d1gz0a1 100.0 19 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:SpoU-like RNA 2'-O ribose methyltransferase 9 c1gz0G_ 100.0 19 PDB header:transferase Chain: G: PDB Molecule:hypothetical trna/rrna methyltransferase yjfh; PDBTitle: 23s ribosomal rna g2251 2'o-methyltransferase rlmb 10 c1ipaA_ 100.0 22 PDB header:transferase Chain: A: PDB Molecule:rna 2'-o-ribose methyltransferase; PDBTitle: crystal structure of rna 2'-o ribose methyltransferase 11 c3dcmX_ 100.0 17 PDB header:transferase Chain: X: PDB Molecule:uncharacterized protein tm_1570; PDBTitle: crystal structure of the thermotoga maritima spout family2 rna-methyltransferase protein tm1570 in complex with s-3 adenosyl-l-methionine 12 c1x7pB_ 100.0 19 PDB header:transferase Chain: B: PDB Molecule:rrna methyltransferase; PDBTitle: crystal structure of the spou methyltransferase avirb from2 streptomyces viridochromogenes in complex with the cofactor adomet 13 d1ipaa1 100.0 21 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:SpoU-like RNA 2'-O ribose methyltransferase 14 c2i6dA_ 100.0 21 PDB header:transferase Chain: A: PDB Molecule:rna methyltransferase, trmh family; PDBTitle: the structure of a putative rna methyltransferase of the trmh family2 from porphyromonas gingivalis. 15 d1mxia_ 100.0 18 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:SpoU-like RNA 2'-O ribose methyltransferase 16 c3gyqB_ 100.0 20 PDB header:transferase Chain: B: PDB Molecule:rrna (adenosine-2'-o-)-methyltransferase; PDBTitle: structure of the thiostrepton-resistance methyltransferase2 s-adenosyl-l-methionine complex 17 c3l8uA_ 100.0 24 PDB header:transferase Chain: A: PDB Molecule:putative rrna methylase; PDBTitle: crystal structure of smu.1707c, a putative rrna methyltransferase from2 streptococcus mutans ua159 18 c3e5yB_ 100.0 24 PDB header:transferase Chain: B: PDB Molecule:trmh family rna methyltransferase; PDBTitle: crystal structure of trmh family rna methyltransferase from2 burkholderia pseudomallei 19 c1vhkA_ 95.7 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein yqeu; PDBTitle: crystal structure of an hypothetical protein 20 d1vhka2 95.2 11 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:YggJ C-terminal domain-like 21 d1duvg2 not modelled 95.0 18 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 22 c2egwB_ not modelled 94.9 17 PDB header:rna methyltransferase Chain: B: PDB Molecule:upf0088 protein aq_165; PDBTitle: crystal structure of rrna methyltransferase with sah ligand 23 d1pvva2 not modelled 94.8 19 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 24 d1otha2 not modelled 94.7 18 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 25 d1dxha2 not modelled 94.3 17 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 26 d1vlva2 not modelled 93.9 26 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 27 c2w37A_ not modelled 93.7 23 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase, catabolic; PDBTitle: crystal structure of the hexameric catabolic ornithine2 transcarbamylase from lactobacillus hilgardii 28 d1ml4a2 not modelled 93.7 16 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 29 c1a1sA_ not modelled 93.7 19 PDB header:transcarbamylase Chain: A: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: ornithine carbamoyltransferase from pyrococcus furiosus 30 d1nxza2 not modelled 93.6 12 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:YggJ C-terminal domain-like 31 c1vhyB_ not modelled 93.5 11 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein hi0303; PDBTitle: crystal structure of haemophilus influenzae protein hi0303, pfam2 duf558 32 d1ekxa2 not modelled 92.9 15 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 33 c2otcA_ not modelled 92.5 19 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: ornithine transcarbamoylase complexed with n-2 (phosphonacetyl)-l-ornithine 34 d1v6za2 not modelled 92.4 14 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:YggJ C-terminal domain-like 35 c3updA_ not modelled 92.2 21 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: 2.9 angstrom crystal structure of ornithine carbamoyltransferase2 (argf) from vibrio vulnificus 36 c1vlvA_ not modelled 92.2 24 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: crystal structure of ornithine carbamoyltransferase (tm1097) from2 thermotoga maritima at 2.25 a resolution 37 c2p2gD_ not modelled 92.0 23 PDB header:transferase Chain: D: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: crystal structure of ornithine carbamoyltransferase from mycobacterium2 tuberculosis (rv1656): orthorhombic form 38 c1ortD_ not modelled 91.5 16 PDB header:transferase Chain: D: PDB Molecule:ornithine transcarbamoylase; PDBTitle: ornithine transcarbamoylase from pseudomonas aeruginosa 39 d1pg5a2 not modelled 91.3 12 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 40 d1tuga1 not modelled 90.0 13 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 41 c3d6nB_ not modelled 90.0 13 PDB header:hydrolase/transferase Chain: B: PDB Molecule:aspartate carbamoyltransferase; PDBTitle: crystal structure of aquifex dihydroorotase activated by aspartate2 transcarbamoylase 42 c3kw2A_ not modelled 89.7 11 PDB header:transferase Chain: A: PDB Molecule:probable r-rna methyltransferase; PDBTitle: crystal structure of probable rrna-methyltransferase from2 porphyromonas gingivalis 43 c1fvoB_ not modelled 89.6 19 PDB header:transferase Chain: B: PDB Molecule:ornithine transcarbamylase; PDBTitle: crystal structure of human ornithine transcarbamylase complexed with2 carbamoyl phosphate 44 c2cx8B_ not modelled 89.5 15 PDB header:transferase Chain: B: PDB Molecule:methyl transferase; PDBTitle: crystal structure of methyltransferase with ligand(sah) 45 c2yy8B_ not modelled 89.1 16 PDB header:transferase Chain: B: PDB Molecule:upf0106 protein ph0461; PDBTitle: crystal structure of archaeal trna-methylase for position2 56 (atrm56) from pyrococcus horikoshii, complexed with s-3 adenosyl-l-methionine 46 c1pg5A_ not modelled 88.9 12 PDB header:transferase Chain: A: PDB Molecule:aspartate carbamoyltransferase; PDBTitle: crystal structure of the unligated (t-state) aspartate2 transcarbamoylase from the extremely thermophilic archaeon sulfolobus3 acidocaldarius 47 c2rgwD_ not modelled 88.6 19 PDB header:transferase Chain: D: PDB Molecule:aspartate carbamoyltransferase; PDBTitle: catalytic subunit of m. jannaschii aspartate2 transcarbamoylase 48 d1js1x2 not modelled 87.1 22 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 49 c3grfA_ not modelled 85.3 22 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: x-ray structure of ornithine transcarbamoylase from giardia2 lamblia 50 c1ml4A_ not modelled 85.2 15 PDB header:transferase Chain: A: PDB Molecule:aspartate transcarbamoylase; PDBTitle: the pala-liganded aspartate transcarbamoylase catalytic subunit from2 pyrococcus abyssi 51 d2o3aa1 not modelled 83.8 18 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:AF0751-like 52 c3q98A_ not modelled 82.8 17 PDB header:transferase Chain: A: PDB Molecule:transcarbamylase; PDBTitle: structure of ygew encoded protein from e. coli 53 c3gd5D_ not modelled 82.8 21 PDB header:transferase Chain: D: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: crystal structure of ornithine carbamoyltransferase from gloeobacter2 violaceus 54 c2ef0A_ not modelled 82.6 23 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: crystal structure of ornithine carbamoyltransferase from thermus2 thermophilus 55 d2at2a2 not modelled 79.8 14 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 56 c3n7uD_ not modelled 74.1 31 PDB header:oxidoreductase Chain: D: PDB Molecule:formate dehydrogenase; PDBTitle: nad-dependent formate dehydrogenase from higher-plant arabidopsis2 thaliana in complex with nad and azide 57 c3sdsA_ not modelled 72.6 21 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase, mitochondrial; PDBTitle: crystal structure of a mitochondrial ornithine carbamoyltransferase2 from coccidioides immitis 58 c3lxmC_ not modelled 72.2 16 PDB header:transferase Chain: C: PDB Molecule:aspartate carbamoyltransferase; PDBTitle: 2.00 angstrom resolution crystal structure of a catalytic2 subunit of an aspartate carbamoyltransferase (pyrb) from3 yersinia pestis co92 59 d2naca1 not modelled 72.1 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 60 c1js1Z_ not modelled 71.9 22 PDB header:transferase Chain: Z: PDB Molecule:transcarbamylase; PDBTitle: crystal structure of a new transcarbamylase from the2 anaerobic bacterium bacteroides fragilis at 2.0 a3 resolution 61 d2qmma1 not modelled 71.7 18 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:AF1056-like 62 c1zq2A_ not modelled 70.5 26 PDB header:transferase Chain: A: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: crystal structure of n-acetyl-l-ornithine transcarbamylase2 complexed with cp 63 c3gg9C_ not modelled 69.2 14 PDB header:oxidoreductase Chain: C: PDB Molecule:d-3-phosphoglycerate dehydrogenase oxidoreductase protein; PDBTitle: crystal structure of putative d-3-phosphoglycerate dehydrogenase2 oxidoreductase from ralstonia solanacearum 64 d1ygya1 not modelled 68.2 28 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 65 c2omeA_ not modelled 68.1 25 PDB header:oxidoreductase Chain: A: PDB Molecule:c-terminal-binding protein 2; PDBTitle: crystal structure of human ctbp2 dehydrogenase complexed with nad(h) 66 c3ijpA_ not modelled 67.4 18 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrodipicolinate reductase; PDBTitle: crystal structure of dihydrodipicolinate reductase from2 bartonella henselae at 2.0a resolution 67 d1qp8a1 not modelled 65.8 24 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 68 c1k3rA_ not modelled 65.4 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved protein mt0001; PDBTitle: crystal structure of the methyltransferase with a knot from2 methanobacterium thermoautotrophicum 69 c2nacA_ not modelled 65.1 23 PDB header:oxidoreductase(aldehyde(d),nad+(a)) Chain: A: PDB Molecule:nad-dependent formate dehydrogenase; PDBTitle: high resolution structures of holo and apo formate dehydrogenase 70 c2j6iC_ not modelled 64.4 21 PDB header:oxidoreductase Chain: C: PDB Molecule:formate dehydrogenase; PDBTitle: candida boidinii formate dehydrogenase (fdh) c-terminal2 mutant 71 c1d4fD_ not modelled 63.0 25 PDB header:hydrolase Chain: D: PDB Molecule:s-adenosylhomocysteine hydrolase; PDBTitle: crystal structure of recombinant rat-liver d244e mutant s-2 adenosylhomocysteine hydrolase 72 d1mx3a1 not modelled 62.3 27 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 73 c1gdhA_ not modelled 60.7 17 PDB header:oxidoreductase(choh (d)-nad(p)+ (a)) Chain: A: PDB Molecule:d-glycerate dehydrogenase; PDBTitle: crystal structure of a nad-dependent d-glycerate2 dehydrogenase at 2.4 angstroms resolution 74 c2g76A_ not modelled 60.1 24 PDB header:oxidoreductase Chain: A: PDB Molecule:d-3-phosphoglycerate dehydrogenase; PDBTitle: crystal structure of human 3-phosphoglycerate dehydrogenase 75 c3evtA_ not modelled 59.6 26 PDB header:oxidoreductase Chain: A: PDB Molecule:phosphoglycerate dehydrogenase; PDBTitle: crystal structure of phosphoglycerate dehydrogenase from2 lactobacillus plantarum 76 d1k3ra2 not modelled 58.3 16 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:Hypothetical protein MTH1 (MT0001), dimerisation domain 77 c3gvpB_ not modelled 57.9 20 PDB header:hydrolase Chain: B: PDB Molecule:adenosylhomocysteinase 3; PDBTitle: human sahh-like domain of human adenosylhomocysteinase 3 78 c3dhyC_ not modelled 57.3 29 PDB header:hydrolase Chain: C: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structures of mycobacterium tuberculosis s-adenosyl-l-2 homocysteine hydrolase in ternary complex with substrate and3 inhibitors 79 d1gdha1 not modelled 56.2 17 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 80 c1j4aA_ not modelled 54.3 18 PDB header:oxidoreductase Chain: A: PDB Molecule:d-lactate dehydrogenase; PDBTitle: insights into domain closure, substrate specificity and2 catalysis of d-lactate dehydrogenase from lactobacillus3 bulgaricus 81 d1sc6a1 not modelled 54.2 25 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Formate/glycerate dehydrogenases, NAD-domain 82 c1qp8A_ not modelled 52.4 22 PDB header:oxidoreductase Chain: A: PDB Molecule:formate dehydrogenase; PDBTitle: crystal structure of a putative formate dehydrogenase from2 pyrobaculum aerophilum 83 c2w2kB_ not modelled 51.3 29 PDB header:oxidoreductase Chain: B: PDB Molecule:d-mandelate dehydrogenase; PDBTitle: crystal structure of the apo forms of rhodotorula graminis2 d-mandelate dehydrogenase at 1.8a. 84 d1vh0a_ not modelled 51.1 22 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:YbeA-like 85 c1mldA_ not modelled 50.3 22 PDB header:oxidoreductase(nad(a)-choh(d)) Chain: A: PDB Molecule:malate dehydrogenase; PDBTitle: refined structure of mitochondrial malate dehydrogenase2 from porcine heart and the consensus structure for3 dicarboxylic acid oxidoreductases 86 c3oneA_ not modelled 49.9 22 PDB header:hydrolase/hydrolase substrate Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of lupinus luteus s-adenosyl-l-homocysteine2 hydrolase in complex with adenine 87 d1o6da_ not modelled 49.2 19 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:YbeA-like 88 c2a9fB_ not modelled 48.4 20 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative malic enzyme ((s)-malate:nad+ PDBTitle: crystal structure of a putative malic enzyme ((s)-2 malate:nad+ oxidoreductase (decarboxylating)) 89 d2atca2 not modelled 48.0 13 Fold:ATC-like Superfamily:Aspartate/ornithine carbamoyltransferase Family:Aspartate/ornithine carbamoyltransferase 90 c3tpfF_ not modelled 47.9 14 PDB header:transferase Chain: F: PDB Molecule:ornithine carbamoyltransferase; PDBTitle: crystal structure of anabolic ornithine carbamoyltransferase from2 campylobacter jejuni subsp. jejuni nctc 11168 91 c2at2B_ not modelled 47.6 15 PDB header: PDB COMPND: 92 d1oi7a1 not modelled 47.5 23 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:CoA-binding domain 93 c3hg7A_ not modelled 47.1 22 PDB header:oxidoreductase Chain: A: PDB Molecule:d-isomer specific 2-hydroxyacid dehydrogenase family PDBTitle: crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase2 family protein from aeromonas salmonicida subsp. salmonicida a449 94 c2gcgB_ not modelled 47.0 22 PDB header:oxidoreductase Chain: B: PDB Molecule:glyoxylate reductase/hydroxypyruvate reductase; PDBTitle: ternary crystal structure of human glyoxylate2 reductase/hydroxypyruvate reductase 95 c3pqeD_ not modelled 46.9 17 PDB header:oxidoreductase Chain: D: PDB Molecule:l-lactate dehydrogenase; PDBTitle: crystal structure of l-lactate dehydrogenase from bacillus subtilis2 with h171c mutation 96 d1diha1 not modelled 46.8 18 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 97 c2pi1C_ not modelled 45.8 22 PDB header:oxidoreductase Chain: C: PDB Molecule:d-lactate dehydrogenase; PDBTitle: crystal structure of d-lactate dehydrogenase from aquifex2 aeolicus complexed with nad and lactic acid 98 d1ns5a_ not modelled 45.7 21 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:YbeA-like 99 c2dbqA_ not modelled 45.2 20 PDB header:oxidoreductase Chain: A: PDB Molecule:glyoxylate reductase; PDBTitle: crystal structure of glyoxylate reductase (ph0597) from pyrococcus2 horikoshii ot3, complexed with nadp (i41) 100 c3bazA_ not modelled 44.9 19 PDB header:oxidoreductase Chain: A: PDB Molecule:hydroxyphenylpyruvate reductase; PDBTitle: structure of hydroxyphenylpyruvate reductase from coleus blumei in2 complex with nadp+ 101 c1wwkA_ not modelled 43.3 24 PDB header:oxidoreductase Chain: A: PDB Molecule:phosphoglycerate dehydrogenase; PDBTitle: crystal structure of phosphoglycerate dehydrogenase from pyrococcus2 horikoshii ot3 102 c3ktdC_ not modelled 42.9 23 PDB header:oxidoreductase Chain: C: PDB Molecule:prephenate dehydrogenase; PDBTitle: crystal structure of a putative prephenate dehydrogenase (cgl0226)2 from corynebacterium glutamicum atcc 13032 at 2.60 a resolution 103 c1drwA_ not modelled 42.3 17 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrodipicolinate reductase; PDBTitle: escherichia coli dhpr/nhdh complex 104 c1gpjA_ not modelled 42.3 21 PDB header:reductase Chain: A: PDB Molecule:glutamyl-trna reductase; PDBTitle: glutamyl-trna reductase from methanopyrus kandleri 105 c3n58D_ not modelled 42.0 27 PDB header:hydrolase Chain: D: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of s-adenosyl-l-homocysteine hydrolase from brucella2 melitensis in ternary complex with nad and adenosine, orthorhombic3 form 106 c3d0oA_ not modelled 42.0 15 PDB header:oxidoreductase Chain: A: PDB Molecule:l-lactate dehydrogenase 1; PDBTitle: crystal structure of lactate dehydrogenase from2 staphylococcus aureus 107 c1z85B_ not modelled 40.8 11 PDB header:transferase Chain: B: PDB Molecule:hypothetical protein tm1380; PDBTitle: crystal structure of a predicted rna methyltransferase (tm1380) from2 thermotoga maritima msb8 at 2.12 a resolution 108 d1to0a_ not modelled 40.7 13 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:YbeA-like 109 c1v8bA_ not modelled 40.2 25 PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteinase; PDBTitle: crystal structure of a hydrolase 110 c1ybaC_ not modelled 39.9 25 PDB header:oxidoreductase Chain: C: PDB Molecule:d-3-phosphoglycerate dehydrogenase; PDBTitle: the active form of phosphoglycerate dehydrogenase 111 c1dxyA_ not modelled 39.1 13 PDB header:oxidoreductase Chain: A: PDB Molecule:d-2-hydroxyisocaproate dehydrogenase; PDBTitle: structure of d-2-hydroxyisocaproate dehydrogenase 112 d7reqb2 not modelled 37.6 23 Fold:Flavodoxin-like Superfamily:Cobalamin (vitamin B12)-binding domain Family:Cobalamin (vitamin B12)-binding domain 113 d1gpja2 not modelled 37.1 26 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Aminoacid dehydrogenase-like, C-terminal domain 114 c2d4aC_ not modelled 36.1 23 PDB header:oxidoreductase Chain: C: PDB Molecule:malate dehydrogenase; PDBTitle: structure of the malate dehydrogenase from aeropyrum pernix 115 c2d0iC_ not modelled 35.7 24 PDB header:oxidoreductase Chain: C: PDB Molecule:dehydrogenase; PDBTitle: crystal structure ph0520 protein from pyrococcus horikoshii ot3 116 c2eklA_ not modelled 35.0 20 PDB header:oxidoreductase Chain: A: PDB Molecule:d-3-phosphoglycerate dehydrogenase; PDBTitle: structure of st1218 protein from sulfolobus tokodaii 117 c3oirA_ not modelled 34.5 24 PDB header:transport protein Chain: A: PDB Molecule:sulfate transporter sulfate transporter family protein; PDBTitle: crystal structure of sulfate transporter family protein from wolinella2 succinogenes 118 c2fnzA_ not modelled 32.7 16 PDB header:oxidoreductase Chain: A: PDB Molecule:lactate dehydrogenase; PDBTitle: crystal structure of the lactate dehydrogenase from cryptosporidium2 parvum complexed with cofactor (b-nicotinamide adenine dinucleotide)3 and inhibitor (oxamic acid) 119 c2cukC_ not modelled 32.6 27 PDB header:oxidoreductase Chain: C: PDB Molecule:glycerate dehydrogenase/glyoxylate reductase; PDBTitle: crystal structure of tt0316 protein from thermus thermophilus hb8 120 c1xdwA_ not modelled 32.2 19 PDB header:oxidoreductase Chain: A: PDB Molecule:nad+-dependent (r)-2-hydroxyglutarate PDBTitle: nad+-dependent (r)-2-hydroxyglutarate dehydrogenase from2 acidaminococcus fermentans

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0