BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (865 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_Q9KRB2 DNA topoisomerase 1 n=401 Tax=cellular organisms... 1296 0.0 UniRef50_Q8K9P7 DNA topoisomerase 1 n=2 Tax=Gammaproteobacteria ... 964 0.0 UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia st... 571 e-161 UniRef50_C9LSJ2 DNA topoisomerase n=3 Tax=Veillonellaceae RepID=... 545 e-153 UniRef50_C0W9S2 DNA topoisomerase n=1 Tax=Acidaminococcus sp. D2... 540 e-151 UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_... 538 e-151 UniRef50_B0MRI8 DNA topoisomerase n=1 Tax=Eubacterium siraeum DS... 534 e-150 UniRef50_C1SMY2 DNA topoisomerase n=1 Tax=Denitrovibrio acetiphi... 530 e-149 UniRef50_D0LR99 DNA topoisomerase n=169 Tax=cellular organisms R... 529 e-148 UniRef50_B1GYR4 DNA topoisomerase n=1 Tax=uncultured Termite gro... 529 e-148 UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=T... 519 e-145 UniRef50_Q01N68 DNA topoisomerase n=7 Tax=Bacteria RepID=Q01N68_... 516 e-144 UniRef50_A7NJW2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A7NJW... 515 e-144 UniRef50_C6BUQ9 DNA topoisomerase n=14 Tax=Desulfovibrionales Re... 515 e-144 UniRef50_Q2FZ32 DNA topoisomerase 1 n=260 Tax=Bacteria RepID=TOP... 514 e-144 UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5... 511 e-143 UniRef50_Q2LT40 DNA topoisomerase n=2 Tax=Bacteria RepID=Q2LT40_... 509 e-142 UniRef50_C1F6V0 DNA topoisomerase n=1 Tax=Acidobacterium capsula... 504 e-141 UniRef50_A3EPL6 DNA topoisomerase n=2 Tax=Leptospirillum sp. Gro... 501 e-140 UniRef50_D1BMP2 DNA topoisomerase n=6 Tax=Firmicutes RepID=D1BMP... 501 e-140 UniRef50_Q9KA23 DNA topoisomerase 1 n=107 Tax=Bacteria RepID=TOP... 501 e-140 UniRef50_B5YKX8 DNA topoisomerase n=1 Tax=Thermodesulfovibrio ye... 501 e-140 UniRef50_C0QYG0 DNA topoisomerase n=2 Tax=Brachyspira RepID=C0QY... 501 e-140 UniRef50_B9L0B0 DNA topoisomerase n=1 Tax=Thermomicrobium roseum... 500 e-139 UniRef50_D1U7W1 DNA topoisomerase n=1 Tax=Desulfovibrio aespoeen... 499 e-139 UniRef50_A8ZW15 DNA topoisomerase n=3 Tax=Desulfobacteraceae Rep... 496 e-138 UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8... 496 e-138 UniRef50_B5EJ79 DNA topoisomerase n=61 Tax=Proteobacteria RepID=... 494 e-138 UniRef50_A8SJ74 DNA topoisomerase n=1 Tax=Parvimonas micra ATCC ... 493 e-137 UniRef50_Q67PC7 DNA topoisomerase n=3 Tax=Bacteria RepID=Q67PC7_... 492 e-137 UniRef50_B2KBN6 DNA topoisomerase n=1 Tax=Elusimicrobium minutum... 486 e-135 UniRef50_C1ABE5 DNA topoisomerase n=1 Tax=Gemmatimonas aurantiac... 485 e-135 UniRef50_Q1RIM1 DNA topoisomerase 1 n=35 Tax=Rickettsiales RepID... 485 e-135 UniRef50_D1C7I9 DNA topoisomerase n=8 Tax=Bacteria RepID=D1C7I9_... 484 e-135 UniRef50_Q7NGH1 DNA topoisomerase n=1 Tax=Gloeobacter violaceus ... 483 e-134 UniRef50_B3EPW7 DNA topoisomerase n=12 Tax=Chlorobiaceae RepID=B... 483 e-134 UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_... 479 e-133 UniRef50_B9L7D9 DNA topoisomerase n=1 Tax=Nautilia profundicola ... 478 e-133 UniRef50_D1B6D6 DNA topoisomerase I n=3 Tax=Synergistaceae RepID... 478 e-133 UniRef50_C6WSV7 DNA topoisomerase n=4 Tax=Proteobacteria RepID=C... 478 e-133 UniRef50_A0LDV2 DNA topoisomerase I n=7 Tax=Proteobacteria RepID... 476 e-132 UniRef50_A9FRC6 DNA topoisomerase I n=1 Tax=Sorangium cellulosum... 476 e-132 UniRef50_C6HWV0 DNA topoisomerase n=1 Tax=Leptospirillum ferrodi... 473 e-131 UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM ... 473 e-131 UniRef50_D1B572 DNA topoisomerase n=7 Tax=Campylobacterales RepI... 472 e-131 UniRef50_A8RBU5 DNA topoisomerase n=9 Tax=Bacteria RepID=A8RBU5_... 470 e-131 UniRef50_A6DJX4 DNA topoisomerase n=2 Tax=Bacteria RepID=A6DJX4_... 469 e-130 UniRef50_D1Y390 DNA topoisomerase n=1 Tax=Pyramidobacter piscole... 468 e-130 UniRef50_Q256J1 DNA topoisomerase I-fused to SWI domain n=18 Tax... 468 e-130 UniRef50_Q1UZD4 DNA topoisomerase n=4 Tax=Bacteria RepID=Q1UZD4_... 466 e-129 UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM ... 464 e-129 UniRef50_C7NA27 DNA topoisomerase n=20 Tax=Fusobacteriaceae RepI... 462 e-128 UniRef50_D0GKB0 DNA topoisomerase n=1 Tax=Leptotrichia goodfello... 459 e-127 UniRef50_Q9X909 DNA topoisomerase 1 n=14 Tax=cellular organisms ... 459 e-127 UniRef50_A6DDI1 DNA topoisomerase n=1 Tax=Caminibacter mediatlan... 459 e-127 UniRef50_D0D7V2 DNA topoisomerase n=1 Tax=Citreicella sp. SE45 R... 459 e-127 UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophi... 457 e-127 UniRef50_O83409 DNA topoisomerase 1 n=4 Tax=Treponema RepID=TOP1... 457 e-126 UniRef50_B1VM20 DNA topoisomerase n=6 Tax=Streptomyces RepID=B1V... 455 e-126 UniRef50_B8E2F6 DNA topoisomerase n=1 Tax=Dictyoglomus turgidum ... 454 e-126 UniRef50_Q31J81 DNA topoisomerase n=6 Tax=Bacteria RepID=Q31J81_... 452 e-125 UniRef50_A5CF60 DNA topoisomerase n=2 Tax=Orientia tsutsugamushi... 451 e-125 UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria ... 447 e-124 UniRef50_D0KVS8 DNA topoisomerase n=6 Tax=Gammaproteobacteria Re... 447 e-124 UniRef50_B1M0P4 DNA topoisomerase n=14 Tax=Alphaproteobacteria R... 447 e-123 UniRef50_C6P2V7 DNA topoisomerase n=2 Tax=Proteobacteria RepID=C... 446 e-123 UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q... 444 e-123 UniRef50_Q9ZMV7 DNA topoisomerase 1 n=47 Tax=Epsilonproteobacter... 444 e-123 UniRef50_C6XXX5 DNA topoisomerase n=76 Tax=Bacteria RepID=C6XXX5... 444 e-123 UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria Re... 443 e-122 UniRef50_A4CJB9 DNA topoisomerase n=4 Tax=Bacteria RepID=A4CJB9_... 441 e-122 UniRef50_Q28MI5 DNA topoisomerase n=13 Tax=Rhodobacterales RepID... 439 e-121 UniRef50_B0VJB5 DNA topoisomerase n=1 Tax=Candidatus Cloacamonas... 438 e-121 UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria... 438 e-121 UniRef50_C6V581 DNA topoisomerase n=2 Tax=Neorickettsia RepID=C6... 436 e-120 UniRef50_A8EWX5 DNA topoisomerase I n=2 Tax=Campylobacterales Re... 435 e-120 UniRef50_Q47L55 DNA topoisomerase n=4 Tax=Actinomycetales RepID=... 433 e-119 UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms R... 432 e-119 UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus R... 430 e-118 UniRef50_O69548 DNA topoisomerase 1 n=28 Tax=Actinomycetales Rep... 430 e-118 UniRef50_C1D174 DNA topoisomerase n=34 Tax=cellular organisms Re... 427 e-118 UniRef50_D0LEI6 DNA topoisomerase n=36 Tax=Actinomycetales RepID... 426 e-117 UniRef50_C7MGF4 DNA topoisomerase n=5 Tax=Actinobacteridae RepID... 424 e-117 UniRef50_D1N8U4 DNA topoisomerase n=1 Tax=Victivallis vadensis A... 424 e-117 UniRef50_A9BI47 DNA topoisomerase n=3 Tax=Thermotogaceae RepID=A... 424 e-116 UniRef50_D2QCS0 DNA topoisomerase I n=1 Tax=Spirosoma linguale D... 424 e-116 UniRef50_B8DVL2 DNA topoisomerase n=14 Tax=Actinobacteridae RepI... 416 e-114 UniRef50_Q2J4Z1 DNA topoisomerase n=10 Tax=Bacteria RepID=Q2J4Z1... 413 e-113 UniRef50_B3DUA2 DNA topoisomerase n=13 Tax=Actinobacteridae RepI... 413 e-113 UniRef50_A8F3N1 DNA topoisomerase n=2 Tax=Thermotogaceae RepID=A... 412 e-113 UniRef50_A1AXT2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A1AXT... 410 e-112 UniRef50_O34204 DNA topoisomerase 1 n=8 Tax=Thermotogaceae RepID... 409 e-112 UniRef50_C4FH65 DNA topoisomerase n=1 Tax=Bifidobacterium angula... 407 e-111 UniRef50_Q6XZ01 DNA topoisomerase n=2 Tax=Spiroplasma RepID=Q6XZ... 406 e-111 UniRef50_P34185 DNA topoisomerase 1 n=39 Tax=Bacteria RepID=TOP1... 405 e-111 UniRef50_P73810 DNA topoisomerase 1 n=13 Tax=cellular organisms ... 404 e-111 UniRef50_Q83FM2 DNA topoisomerase n=2 Tax=Tropheryma whipplei Re... 402 e-110 UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2... 400 e-110 UniRef50_C0W593 DNA topoisomerase n=1 Tax=Actinomyces urogenital... 398 e-109 UniRef50_C3JAB5 DNA topoisomerase n=3 Tax=Bacteria RepID=C3JAB5_... 392 e-107 UniRef50_C1E9E3 DNA topoisomerase n=1 Tax=Micromonas sp. RCC299 ... 373 e-101 UniRef50_C5Z4V5 DNA topoisomerase (Fragment) n=12 Tax=cellular o... 370 e-101 UniRef50_A4RYV6 DNA topoisomerase (Fragment) n=5 Tax=cellular or... 369 e-100 UniRef50_C6XEP4 DNA topoisomerase I n=1 Tax=Methylovorus sp. SIP... 368 e-100 UniRef50_D0JAY2 DNA topoisomerase n=2 Tax=Blattabacterium RepID=... 367 e-99 UniRef50_O66893 DNA topoisomerase 1 n=2 Tax=Aquificaceae RepID=T... 361 9e-98 UniRef50_B7I2H2 DNA topoisomerase n=4 Tax=Proteobacteria RepID=B... 360 1e-97 UniRef50_B7KK14 DNA topoisomerase n=4 Tax=Cyanobacteria RepID=B7... 357 8e-97 UniRef50_Q3M6J7 DNA topoisomerase n=12 Tax=Cyanobacteria RepID=Q... 357 1e-96 UniRef50_B1VAJ5 DNA topoisomerase n=6 Tax=Acholeplasmataceae Rep... 351 6e-95 UniRef50_B5TTQ4 TraB n=3 Tax=environmental samples RepID=B5TTQ4_... 350 2e-94 UniRef50_C1MSJ2 DNA topoisomerase n=1 Tax=Micromonas pusilla CCM... 343 2e-92 UniRef50_A8II62 DNA topoisomerase (Fragment) n=1 Tax=Chlamydomon... 342 3e-92 UniRef50_A4BJY7 Topoisomerase I n=1 Tax=Reinekea blandensis MED2... 341 6e-92 UniRef50_Q9PHK2 DNA topoisomerase I, plasmid n=3 Tax=Gammaproteo... 341 7e-92 UniRef50_B7GCB2 DNA topoisomerase (Fragment) n=1 Tax=Phaeodactyl... 341 8e-92 UniRef50_O51768 DNA topoisomerase 1 n=22 Tax=Borrelia RepID=TOP1... 341 8e-92 UniRef50_Q8EVZ3 DNA topoisomerase n=1 Tax=Mycoplasma penetrans R... 340 1e-91 UniRef50_A3BAP2 DNA topoisomerase n=6 Tax=Poaceae RepID=A3BAP2_O... 339 3e-91 UniRef50_B2V7T0 DNA topoisomerase I n=5 Tax=Aquificales RepID=B2... 339 3e-91 UniRef50_Q5UQB5 DNA topoisomerase 1 type prokaryotic n=1 Tax=Aca... 335 5e-90 UniRef50_B1X1Z5 DNA topoisomerase n=3 Tax=Chroococcales RepID=B1... 332 3e-89 UniRef50_Q02GM2 DNA topoisomerase n=10 Tax=Pseudomonas RepID=Q02... 332 5e-89 UniRef50_UPI00016C444E DNA topoisomerase I n=1 Tax=Gemmata obscu... 332 5e-89 UniRef50_P78032 DNA topoisomerase 1 n=2 Tax=Mycoplasma RepID=TOP... 331 9e-89 UniRef50_A6G953 DNA topoisomerase n=1 Tax=Plesiocystis pacifica ... 324 7e-87 UniRef50_Q9JN65 DNA topoisomerase 1 n=2 Tax=Mycoplasma gallisept... 324 9e-87 UniRef50_B1AJN1 DNA topoisomerase I n=15 Tax=Ureaplasma RepID=B1... 322 3e-86 UniRef50_Q04TE1 DNA topoisomerase n=4 Tax=Leptospira RepID=Q04TE... 319 4e-85 UniRef50_B7J7I8 DNA topoisomerase I, putative n=1 Tax=Acidithiob... 315 4e-84 UniRef50_B3PMD8 DNA topoisomerase I n=3 Tax=Mycoplasma RepID=B3P... 315 5e-84 UniRef50_A1U7T2 DNA topoisomerase I n=2 Tax=Marinobacter RepID=A... 315 5e-84 UniRef50_Q4A5N2 DNA topoisomerase n=2 Tax=Mycoplasma RepID=Q4A5N... 315 6e-84 UniRef50_O49571 DNA topoisomerase like-protein n=1 Tax=Arabidops... 315 6e-84 UniRef50_C4XEP1 DNA topoisomerase n=2 Tax=Mycoplasma RepID=C4XEP... 311 7e-83 UniRef50_B1M9R9 DNA topoisomerase I n=4 Tax=root RepID=B1M9R9_METRJ 311 1e-82 UniRef50_C2KTI6 DNA topoisomerase n=2 Tax=Mobiluncus mulieris Re... 305 6e-81 UniRef50_A3M2F6 TraB protein n=2 Tax=Acinetobacter baumannii ATC... 296 2e-78 UniRef50_C3SA84 DNA topoisomerase n=1 Tax=Brachypodium distachyo... 285 5e-75 UniRef50_Q4AA55 DNA topoisomerase n=5 Tax=Mycoplasma hyopneumoni... 278 9e-73 UniRef50_UPI0001924CDD PREDICTED: similar to DNA topoisomerase I... 255 5e-66 UniRef50_D1HI22 DNA topoisomerase (Fragment) n=1 Tax=Vitis vinif... 253 3e-65 UniRef50_Q2SR72 DNA topoisomerase n=4 Tax=Mollicutes RepID=Q2SR7... 238 5e-61 UniRef50_UPI0001C41D8C DNA topoisomerase I TopA n=1 Tax=Methanob... 237 1e-60 UniRef50_UPI00006DC642 hypothetical protein CdifQ_04001409 n=1 T... 235 6e-60 UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae ... 231 9e-59 UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepI... 230 1e-58 UniRef50_B0SF59 DNA topoisomerase n=3 Tax=Leptospira biflexa Rep... 226 2e-57 UniRef50_C9R890 Reverse gyrase n=1 Tax=Ammonifex degensii KC4 Re... 222 5e-56 UniRef50_B9LRP1 DNA topoisomerase n=4 Tax=Halobacteriaceae RepID... 221 1e-55 UniRef50_A6Q5V5 Reverse gyrase n=30 Tax=cellular organisms RepID... 209 3e-52 UniRef50_O67226 Topoisomerase n=3 Tax=cellular organisms RepID=R... 206 2e-51 UniRef50_Q18KP8 DNA topoisomerase n=6 Tax=Halobacteriaceae RepID... 205 6e-51 UniRef50_Q64CK3 DNA topoisomerase n=2 Tax=environmental samples ... 204 1e-50 UniRef50_C8WG68 DNA topoisomerase type IA central domain protein... 204 1e-50 UniRef50_B9LA13 Reverse gyrase n=14 Tax=cellular organisms RepID... 202 6e-50 UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_... 200 2e-49 UniRef50_A1RXQ0 Reverse gyrase n=2 Tax=Archaea RepID=A1RXQ0_THEPD 200 2e-49 UniRef50_O67037 Topoisomerase n=11 Tax=cellular organisms RepID=... 198 9e-49 UniRef50_Q74MA4 Reverse gyrase n=1 Tax=Nanoarchaeum equitans Rep... 198 1e-48 UniRef50_UPI0001698F80 DNA topoisomerase I n=1 Tax=Endoriftia pe... 196 3e-48 UniRef50_Q9ZKK4 Topoisomerase I n=9 Tax=Helicobacter RepID=Q9ZKK... 196 4e-48 UniRef50_UPI00019793DC topoisomerase I n=1 Tax=Helicobacter cina... 194 1e-47 UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP... 192 5e-47 UniRef50_O28469 DNA topoisomerase 1 n=8 Tax=Euryarchaeota RepID=... 190 2e-46 UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 189 3e-46 UniRef50_B1L3G6 DNA topoisomerase I n=1 Tax=Candidatus Korarchae... 189 4e-46 UniRef50_C0QU27 Reverse gyrase n=1 Tax=Persephonella marina EX-H... 188 7e-46 UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina E... 185 8e-45 UniRef50_A8A8D9 DNA topoisomerase n=1 Tax=Ignicoccus hospitalis ... 185 8e-45 UniRef50_A3DNK7 Reverse gyrase n=1 Tax=Staphylothermus marinus F... 184 1e-44 UniRef50_B1L5U0 Reverse gyrase n=2 Tax=Archaea RepID=B1L5U0_KORCO 183 2e-44 UniRef50_B7IEV8 Reverse gyrase n=1 Tax=Thermosipho africanus TCF... 182 4e-44 UniRef50_Q8GJE2 TopA n=2 Tax=Campylobacter RepID=Q8GJE2_CAMJJ 182 4e-44 UniRef50_A7I6L6 DNA topoisomerase n=5 Tax=Methanomicrobiales Rep... 182 6e-44 UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6Y... 180 3e-43 UniRef50_B8D4X1 Reverse gyrase n=1 Tax=Desulfurococcus kamchatke... 179 5e-43 UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms Rep... 179 6e-43 UniRef50_Q5V1P3 DNA topoisomerase I n=1 Tax=Haloarcula marismort... 178 6e-43 UniRef50_Q12Y06 DNA topoisomerase n=1 Tax=Methanococcoides burto... 178 8e-43 UniRef50_Q53VZ7 Reverse gyrase n=2 Tax=Thermus thermophilus RepI... 178 8e-43 UniRef50_B9MRC8 Reverse gyrase n=1 Tax=Anaerocellum thermophilum... 178 1e-42 UniRef50_O29238 Topoisomerase n=3 Tax=Archaeoglobaceae RepID=RGY... 177 1e-42 UniRef50_Q8R979 Topoisomerase n=14 Tax=Bacteria RepID=RGYR_THETN 177 2e-42 UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium bacul... 176 3e-42 UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boo... 176 5e-42 UniRef50_A2BLB8 Reverse gyrase n=2 Tax=Hyperthermus butylicus Re... 174 1e-41 UniRef50_Q4QCK3 DNA topoisomerase 1A n=6 Tax=Trypanosomatidae Re... 174 2e-41 UniRef50_A4YIX2 Reverse gyrase n=2 Tax=cellular organisms RepID=... 173 3e-41 UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=... 172 5e-41 UniRef50_D2EGP7 DNA topoisomerase n=1 Tax=Candidatus Parvarchaeu... 172 6e-41 UniRef50_Q97ZF5 Topoisomerase n=12 Tax=Sulfolobaceae RepID=RGYR2... 171 8e-41 UniRef50_A4XJT7 Reverse gyrase n=1 Tax=Caldicellulosiruptor sacc... 171 1e-40 UniRef50_A3DN56 Reverse gyrase n=2 Tax=Archaea RepID=A3DN56_STAMF 171 2e-40 UniRef50_Q0W2I3 DNA topoisomerase I n=2 Tax=Euryarchaeota RepID=... 169 5e-40 UniRef50_Q8ZXT5 Topoisomerase n=5 Tax=Thermoproteaceae RepID=RGY... 169 5e-40 UniRef50_C7DGI7 DNA topoisomerase n=1 Tax=Candidatus Micrarchaeu... 166 3e-39 UniRef50_A8A9U6 Reverse gyrase n=3 Tax=Archaea RepID=A8A9U6_IGNH4 164 2e-38 UniRef50_C9RG81 DNA topoisomerase I n=2 Tax=Methanocaldococcus R... 164 2e-38 UniRef50_A8A9J9 Reverse gyrase n=1 Tax=Ignicoccus hospitalis KIN... 163 2e-38 UniRef50_A8MCZ0 Reverse gyrase n=5 Tax=cellular organisms RepID=... 162 4e-38 UniRef50_B2UU25 Topoisomerase I n=6 Tax=Helicobacter pylori RepI... 162 4e-38 UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3... 162 6e-38 UniRef50_A8U720 DNA topoisomerase n=3 Tax=Lactobacillales RepID=... 162 6e-38 UniRef50_Q08582 Topoisomerase n=11 Tax=Sulfolobus RepID=RGYR_SULAC 161 9e-38 UniRef50_B5IDE0 Reverse gyrase n=3 Tax=Archaea RepID=B5IDE0_9EURY 160 2e-37 UniRef50_B8D628 Reverse gyrase n=1 Tax=Desulfurococcus kamchatke... 160 2e-37 UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria R... 160 3e-37 UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae Rep... 159 4e-37 UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J35... 157 1e-36 UniRef50_Q46AN3 DNA topoisomerase n=3 Tax=Methanosarcina RepID=Q... 157 2e-36 UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms Re... 157 2e-36 UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0... 156 3e-36 UniRef50_Q4DQ13 DNA topoisomerase IA, putative n=3 Tax=Trypanoso... 156 3e-36 UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C... 156 3e-36 UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK... 156 4e-36 UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU... 155 9e-36 UniRef50_A4RZ61 DNA topoisomerase n=2 Tax=cellular organisms Rep... 155 9e-36 UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris... 154 1e-35 UniRef50_A9VVE2 DNA topoisomerase n=18 Tax=Bacillus cereus group... 154 1e-35 UniRef50_D2RGC8 DNA topoisomerase n=2 Tax=Archaeoglobaceae RepID... 154 2e-35 UniRef50_B1YAK4 DNA topoisomerase type IA central domain protein... 154 2e-35 UniRef50_Q9YC75 Topoisomerase n=4 Tax=Archaea RepID=RGYR2_AERPE 153 3e-35 UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribac... 151 1e-34 UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus cald... 151 1e-34 UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infe... 151 1e-34 UniRef50_Q181Z2 DNA topoisomerase n=23 Tax=Clostridium RepID=Q18... 150 1e-34 UniRef50_Q9HM08 DNA topoisomerase 1 n=4 Tax=Thermoplasmatales Re... 150 2e-34 UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum aceto... 149 3e-34 UniRef50_Q9YCB6 Topoisomerase n=1 Tax=Aeropyrum pernix RepID=RGY... 149 4e-34 UniRef50_B1SE14 DNA topoisomerase n=1 Tax=Streptococcus infantar... 149 6e-34 UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=... 148 7e-34 UniRef50_A3DP02 DNA topoisomerase n=9 Tax=Desulfurococcaceae Rep... 148 8e-34 UniRef50_Q1J4U0 DNA topoisomerase n=30 Tax=Bacteria RepID=Q1J4U0... 148 1e-33 UniRef50_O95985 DNA topoisomerase 3-beta-1 n=72 Tax=Eukaryota Re... 148 1e-33 UniRef50_Q13472 DNA topoisomerase 3-alpha n=31 Tax=Eumetazoa Rep... 147 1e-33 UniRef50_C9BSW4 DNA topoisomerase n=54 Tax=Lactobacillales RepID... 147 1e-33 UniRef50_C1DYX0 Predicted protein n=4 Tax=Viridiplantae RepID=C1... 147 2e-33 UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 146 3e-33 UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=... 146 4e-33 UniRef50_A2BLA3 DNA topoisomerase n=1 Tax=Hyperthermus butylicus... 145 5e-33 UniRef50_D2VSX3 Predicted protein n=1 Tax=Naegleria gruberi RepI... 145 7e-33 UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermo... 145 9e-33 UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF... 145 9e-33 UniRef50_Q702B0 DNA topoisomerase n=1 Tax=uncultured crenarchaeo... 145 1e-32 UniRef50_A5FFH7 DNA topoisomerase n=1 Tax=Flavobacterium johnson... 144 1e-32 UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogen... 144 2e-32 UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapo... 143 2e-32 UniRef50_Q33E26 DNA topoisomerase n=5 Tax=Enterococcus faecium R... 143 3e-32 UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula ... 143 3e-32 >UniRef50_Q9KRB2 DNA topoisomerase 1 n=401 Tax=cellular organisms RepID=TOP1_VIBCH Length = 876 Score = 1296 bits (3354), Expect = 0.0, Method: Compositional matrix adjust. Identities = 614/869 (70%), Positives = 724/869 (83%), Gaps = 10/869 (1%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 MGK+LVIVESPAKAKTINKYLG D++VKSSVGH+RDLPT+G A + + + T K Sbjct: 1 MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60 Query: 61 KD--------ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 D ER AL+ +MGVDP+H W+A+Y++LPGKEKVV+EL++LA+ AD +YLATDL Sbjct: 61 TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 DREGEAIAWHLRE+IGGD+ RY RVVFNEITKNAI+QAF +PGELN+D VNAQQARRFMD Sbjct: 121 DREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180 Query: 173 RVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE 232 RVVG+MVSPLLWKK+ARGLSAGRVQSVAV+L+VEREREIKAFVPEEFW+++A T T + Sbjct: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQ 240 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 L V ++ F+PVN+ + AAV+ L KA+Y V +REDKPTTSKP APFITSTLQQA Sbjct: 241 DFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQA 300 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 ASTRLG+GVKKTMM+AQRLYEAGYITYMRTDSTNLS +AV +RGYI+ ++G+ YLP P Sbjct: 301 ASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQP 360 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 N Y SK+N+QEAHEAIRPSDV V A+ L+ MEADA KLY LIW QFVACQMTPA+YDSTT Sbjct: 361 NVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTT 420 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 ++V A ++ LKA+GRIL+FDGWT+V L K +ED+ILP V GD+L LV L P QHFTK Sbjct: 421 VSVKAAEYTLKAKGRILKFDGWTRVQRPLGK-NEDQILPPVKVGDSLKLVSLDPKQHFTK 479 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PPAR++EA+LVKELEKRGIGRPSTYASIISTIQDRGYV+V+ RRF+AEKMGEIVTDRL+E Sbjct: 480 PPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDE 539 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 NF +LMNYDFTA+ME LDQ+A E W AVLD FF+DF++ L+ AE+D GGM+PN + Sbjct: 540 NFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHI 599 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 V+T+I CPTC R MGIRTASTGVFLGCSGY LPPKERCKTTINL E V+NVLE ED E Sbjct: 600 VMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLE-EDVE 658 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 T ALRAK+RCP C TAMD+YLID KRKLHVCGNNP C+G+ +EEGEF++KGY+GP VEC+ Sbjct: 659 TAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECD 718 Query: 713 KCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL 772 KCGS+M LK GRFGKYM CTN+ CKNTRKIL+NGEVAPPKE+PV PELPCE SDAYFVL Sbjct: 719 KCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVL 778 Query: 773 RDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFS 832 RDGA+G+F AA+ FPKSRETRAPLVEEL RF +RLPEK +YL AP DP+G +VRFS Sbjct: 779 RDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFS 838 Query: 833 RKTKQQYVSSEKDGKATGWSAFYVDGKWV 861 RK K+ YV +E +GK +GW A Y +GKW+ Sbjct: 839 RKEKEHYVRTETEGKPSGWMAVYQEGKWL 867 >UniRef50_Q8K9P7 DNA topoisomerase 1 n=2 Tax=Gammaproteobacteria RepID=TOP1_BUCAP Length = 853 Score = 964 bits (2493), Expect = 0.0, Method: Compositional matrix adjust. Identities = 454/863 (52%), Positives = 623/863 (72%), Gaps = 18/863 (2%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+LVIVESP KAKTI+KYLG Y+VKSSVGH+RDL + S KK+ ++ K Sbjct: 1 MCKSLVIVESPVKAKTISKYLGKQYIVKSSVGHVRDLINNKSKNKKNIKKSNIK------ 54 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +E+ AL+ +MG++P+ NW+A Y +LPGKEK++SELK +A K +IYLATDLDREGEAIA Sbjct: 55 HNEKTALIQQMGINPYKNWKAEYHILPGKEKIISELKNIANKVHYIYLATDLDREGEAIA 114 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+EVIGG+ ++ RVVFNEITK +I +AF G++N++RV +QQARRFMDR+VGYM+S Sbjct: 115 WHLKEVIGGNSLKFRRVVFNEITKKSIEKAFQNIGKINMNRVYSQQARRFMDRIVGYMIS 174 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWKKI+RGLSAGRVQS AVRL+ +RE EIK F+ E W++ S + + + + +TH Sbjct: 175 PLLWKKISRGLSAGRVQSAAVRLITDREYEIKNFIEREHWKISLSLLSKENKKVTMDITH 234 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 +K F NK++ + + ++ + + +R+DK KP AP ITSTLQQA++ LGF Sbjct: 235 YRNKTFLLNNKKEVNSTIEKIKNLSFIITDRKDKIFKKKPPAPLITSTLQQASNIDLGFS 294 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 VKKTM +AQ+LYE GYITY+RTDS LS A+ VR YI + +G +LP+ N Y++++ Sbjct: 295 VKKTMFLAQKLYEQGYITYIRTDSYFLSNYAIEKVRSYIENFYGSDFLPKKSNIYSNQKY 354 Query: 361 SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF 420 SQEAHEAIRPSDV V+ ++ + + DA+KLY+LIW F+A QM +Y S TV A F Sbjct: 355 SQEAHEAIRPSDVQVV--NIDNCDPDAKKLYKLIWNYFIASQMKSERYKSIKTTVMADVF 412 Query: 421 RLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEA 480 +L++ +I+ F GWTK++ + + + P ++ G L L ++ P Q FTKPP RFSE+ Sbjct: 413 KLQSNTKIVLFSGWTKILK--KSNNVNFKFPVLDIGTTLILDKILPHQIFTKPPPRFSES 470 Query: 481 SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY 540 SLV+ELEK+GIGRPSTYA+II+ I+++GY++++ +FYA K+GEI+ RL++NF +L++Y Sbjct: 471 SLVRELEKKGIGRPSTYATIITKIKEKGYLKIKKNKFYAAKIGEILITRLKKNFSDLVDY 530 Query: 541 DFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP 600 DFTA+ME +LDQV++ WK +L+ FF +F+QQL++A+K PEEGGM N V T IDC Sbjct: 531 DFTARMEKNLDQVSDKLINWKHLLNSFFDNFSQQLEQAKKPPEEGGMELNTTVPTEIDCS 590 Query: 601 TCGRKMGIRTASTGVFLGCSGYALPPKE-RCKTTINLVPENEVLNVLEGEDAETNALRAK 659 C +KMGI+TA TGVFL C GY P E RCK TINL+ LN L E K Sbjct: 591 LCNKKMGIKTAVTGVFLSCLGYNSEPNEKRCKNTINLIS----LNDLSTTKKEEKNFHLK 646 Query: 660 RRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI--VECEKCGSE 717 RC KC MD YLI+ K+ +C NNP+C+GY +++G F+ K + + ++CEKC ++ Sbjct: 647 NRCKKCNLVMDVYLINENLKIFICINNPSCNGYNLKKGIFK-KSLNCSLKKIKCEKCKND 705 Query: 718 MHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAA 777 M K GRFG + C N+ CKNTRKIL NGE++ PK +P+P P++ CEKS+ +FVLR+G + Sbjct: 706 MLFKTGRFGNFFMCINDTCKNTRKILPNGEISEPKFEPIPFPDILCEKSNTWFVLREGIS 765 Query: 778 GVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQ 837 G+F AANTFPKSRETR+P VEEL RF LP+KL YLA APQ+D +GNKT+V F++ KQ Sbjct: 766 GIFFAANTFPKSRETRSPFVEELARFEYLLPKKLHYLASAPQRDNKGNKTIVCFNKLNKQ 825 Query: 838 QYVSSEKDGKATGWSAFYVDGKW 860 QY++S+K+GK TGW+AF++D KW Sbjct: 826 QYIASKKEGKFTGWAAFFIDRKW 848 >UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PYZ6_9BACT Length = 773 Score = 571 bits (1472), Expect = e-161, Method: Compositional matrix adjust. Identities = 323/764 (42%), Positives = 455/764 (59%), Gaps = 84/764 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKAKTI+K+L + + VKSS+GH+RDLP Sbjct: 8 LVIVESPAKAKTISKFLDASFFVKSSMGHVRDLP-------------------------- 41 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 ++ VD +++ Y+V+P +EK++ EL ++KA +YLA+DLDREGEAIAWHL Sbjct: 42 ---AKKLSVDIENDFTPEYKVIPSREKLIKELISDSKKASTVYLASDLDREGEAIAWHLY 98 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 +V+ + RV FNEITK+AI++AF + G +N+++VNAQQARR +DR+VGY +SPLLW Sbjct: 99 KVLDIPPEKIRRVTFNEITKDAIQEAFKQYGPINMEKVNAQQARRILDRIVGYKISPLLW 158 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDK 244 KKIA+ LSAGRVQSVAVRL+VERE+EI F P E+W++ A T SG+ + + K Sbjct: 159 KKIAKRLSAGRVQSVAVRLIVEREKEINEFKPHEYWKITAELKTISGDKKSDDI-----K 213 Query: 245 PFRPV------------NKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 PF+ + N++Q + L+ A + + + + + PF TS LQQ Sbjct: 214 PFKALLQKLEDKNIEIKNEQQAKEITEKLQNASFIITNIKKQTKRNNAPPPFTTSLLQQQ 273 Query: 293 ASTRLGFGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNF 343 ASTRL F KKTM++AQ+LYE AG ITYMRTDS ++S A+ R +I N+ Sbjct: 274 ASTRLQFSAKKTMLIAQQLYEGIDVGADGPAGLITYMRTDSFHVSDHALTSCRNFIESNY 333 Query: 344 GKKYLPESPNQYAS-KENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 GK YLPE PN YAS K+ +Q AHEA+RP+ + ES+K + D KLY+LIW++FVA Sbjct: 334 GKDYLPEKPNIYASNKKGTQGAHEAVRPTYLEYTPESIKQFLTKDQHKLYELIWKRFVAS 393 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTL 461 QM PA Y T + + + + K RGR L FDG T ++ E++ILP + K L L Sbjct: 394 QMKPALYAITDVEITSNRYIFKTRGRELLFDGHT-LISGHEVDREEQILPPLEKDHVLEL 452 Query: 462 VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521 ++L P QHFT+PP R+SEASLVK LEK GIGRPSTYA+IISTIQDRGYV+ E R FYA + Sbjct: 453 IQLLPTQHFTQPPPRYSEASLVKTLEKMGIGRPSTYATIISTIQDRGYVKQEKRAFYATE 512 Query: 522 MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 +G +VT++L E+F+++M+ +FT+ ME+ LD++ + +W VL F+ F L+KA + Sbjct: 513 LGILVTEKLIEHFQKIMDVNFTSHMEDELDKIEEKKIDWLTVLKEFYEPFKIDLEKAIGE 572 Query: 582 PEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENE 641 + P + + C C + M IR G F GCS + CK N +P +E Sbjct: 573 MKSVKGTPEE---SDRICNLCSKPMVIRWGRHGKFFGCSAFP-----ECK---NTMPLDE 621 Query: 642 VLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR--KLHVCGNNPTCDGYEIEEGEF 699 +GE A + + C KCG+ M +I R K C P C + GE Sbjct: 622 -----KGEAAPPET--SDQACEKCGSPM---IIKTSRHGKFMACSAYPNCKNTKSLTGE- 670 Query: 700 RIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKI 742 + +CEKCGS M ++ + G++M C+ +C+N + + Sbjct: 671 -TTKVEPTNEKCEKCGSPMVIRFSKKGRFMGCSGYPKCRNIKSL 713 Score = 55.8 bits (133), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 31/86 (36%), Positives = 44/86 (51%), Gaps = 10/86 (11%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKIL-RNGEVAPPKEDPVPLPELPCEKSDA 768 CEKCGS M +K R GK+MAC+ CKNT+ + +V P E CEK + Sbjct: 635 CEKCGSPMIIKTSRHGKFMACSAYPNCKNTKSLTGETTKVEPTNEK--------CEKCGS 686 Query: 769 YFVLRDGAAGVFLAANTFPKSRETRA 794 V+R G F+ + +PK R ++ Sbjct: 687 PMVIRFSKKGRFMGCSGYPKCRNIKS 712 Score = 54.3 bits (129), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 26/85 (30%), Positives = 43/85 (50%), Gaps = 6/85 (7%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C C M ++ GR GK+ C+ ECKNT + GE APP+ + CEK + Sbjct: 587 CNLCSKPMVIRWGRHGKFFGCSAFPECKNTMPLDEKGEAAPPETS-----DQACEKCGSP 641 Query: 770 FVLRDGAAGVFLAANTFPKSRETRA 794 +++ G F+A + +P + T++ Sbjct: 642 MIIKTSRHGKFMACSAYPNCKNTKS 666 >UniRef50_C9LSJ2 DNA topoisomerase n=3 Tax=Veillonellaceae RepID=C9LSJ2_9FIRM Length = 836 Score = 545 bits (1405), Expect = e-153, Method: Compositional matrix adjust. Identities = 311/757 (41%), Positives = 442/757 (58%), Gaps = 95/757 (12%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 + LV+VESPAKAKTI KYLG Y+V++S+GH+RDLP S Sbjct: 116 QTLVVVESPAKAKTIEKYLGKKYMVRASMGHLRDLPKS---------------------- 153 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + G+D +++ Y + GK ++ LK+ A+ A +YLA+D DREGEAIAWH Sbjct: 154 -------QFGIDVENDFAPKYINIRGKGDLIKALKKDAKHAAKVYLASDPDREGEAIAWH 206 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L ++G D R+VFNEITK AI+ A +P +N+DRV+AQQARR +DR+VGY +SPL Sbjct: 207 LAHILGIDPNENCRIVFNEITKPAIQAAVKEPYPINLDRVDAQQARRMLDRIVGYKLSPL 266 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LW+KI +GLSAGRVQSV V+L+ +RE+EI+AFVPEE+W V G A ++ + Sbjct: 267 LWRKIKKGLSAGRVQSVTVKLICDREKEIQAFVPEEYWTVGMKLKKGRGAQFAAELATVD 326 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K +KE+T A V + K +SV E + + P APF TS++QQ AS +LGF + Sbjct: 327 GKKLALHSKEETSALVKDMAKQSFSVKEVKKRERRRNPVAPFTTSSMQQDASRKLGFTSR 386 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 +TMM+AQ+LYE G ITYMRTDST LS A++ VRGY+ +FG YLPE PN Sbjct: 387 RTMMIAQQLYEGVELGRRGPVGLITYMRTDSTRLSDLALDEVRGYVGTSFGADYLPEKPN 446 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 YA+ + +Q+AHEAIRP+ V E + K + + +LY LIW++FVA QMTPA +D+ + Sbjct: 447 IYAAGKKAQDAHEAIRPTSVENTPELMEKYLSREQLRLYTLIWQRFVASQMTPAVFDTVS 506 Query: 413 LTVGAGD-FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 ++V AG+ + +A G L+F G+ V A K ++D +LP + G+AL+L++L P QHFT Sbjct: 507 VSVAAGERYIARASGSTLKFPGFLAVY-ADNKKEKDVLLPELAAGEALSLLDLLPEQHFT 565 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 +PP R++EASLVK LE+ IGRPSTYA II TI RGYV +++ F +G +V D LE Sbjct: 566 EPPPRYNEASLVKTLEEEDIGRPSTYAPIIETILARGYVVRQDKHFQPTDLGFLVNDMLE 625 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD------PEEG 585 E+F+++++ FTA +EN LD++A + + +L F+ F + L++A++ PEE Sbjct: 626 EHFKDIVDVQFTAGLENELDEIAEGKVDKNDLLRGFYEPFEKTLEEADEAIGEVEIPEE- 684 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 ++ + C CGR M ++ G FL C G+ C+ T L+ + V Sbjct: 685 --------VSDVICEKCGRNMVVKQGRYGKFLACPGFP-----DCRNTKPLLKDTGV--- 728 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYD 705 CPKCG + + + C N P CD +D Sbjct: 729 ---------------PCPKCGGRIVERRSRRGQAFYGCENYPACD----------YVTWD 763 Query: 706 GPIVE-CEKCGSEM---HLKMGRFGKYMACTNEECKN 738 P+ E C +CG+ M K GR Y C+NEECK Sbjct: 764 QPLTEKCPECGAFMLRHRYKNGRILPY--CSNEECKT 798 Score = 48.9 bits (115), Expect = 0.001, Method: Compositional matrix adjust. Identities = 21/45 (46%), Positives = 31/45 (68%), Gaps = 1/45 (2%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPK 752 V CEKCG M +K GR+GK++AC +C+NT+ +L++ V PK Sbjct: 688 VICEKCGRNMVVKQGRYGKFLACPGFPDCRNTKPLLKDTGVPCPK 732 >UniRef50_C0W9S2 DNA topoisomerase n=1 Tax=Acidaminococcus sp. D21 RepID=C0W9S2_9FIRM Length = 754 Score = 540 bits (1390), Expect = e-151, Method: Compositional matrix adjust. Identities = 301/751 (40%), Positives = 435/751 (57%), Gaps = 82/751 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP K+KTI ++LG +Y VK+S+GH+RDLP S Sbjct: 4 LVIVESPTKSKTIGRFLGKNYTVKASMGHLRDLPKS------------------------ 39 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 + GVD H++E Y + GK ++ ELK LA+KAD IYLATD DREGEAIAWHL Sbjct: 40 -----QFGVDVDHDFEPKYINIRGKGDLIKELKTLAKKADKIYLATDPDREGEAIAWHLG 94 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 ++G D R+ F+EIT +A+++A P +++D+V+AQQ RR +DR+VGY +SPLLW Sbjct: 95 YLLGVDPESNCRISFHEITPHAVKEAIKHPAAIDMDKVDAQQTRRILDRIVGYKLSPLLW 154 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT--PSGEALALQVTHQN 242 +KIA+GLSAGRVQSVAV+++ +R++EI AF P+E+W + T PS + A +VT + Sbjct: 155 RKIAKGLSAGRVQSVAVKIICDRQKEIDAFEPQEYWTSSVTLTADKPSHKFTA-EVTKKE 213 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K N+E+ + L Y+V K +P APF TS+LQQ A RL F K Sbjct: 214 GKKLVIHNEEEARTVTKELLNQSYAVASSAVKDRIRRPIAPFTTSSLQQEAVKRLNFTTK 273 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 KTMM+AQ+LYE G ITYMRTDS +L+ AV +R YI + +G YLP+ PN Sbjct: 274 KTMMLAQQLYEGIALEKRTPVGLITYMRTDSVHLASVAVAEIRNYIGEVYGDAYLPKKPN 333 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 Y+S++N+QEAHEAIRP+ V + + +E D +LY+LIW + V+CQM P+ + TT Sbjct: 334 VYSSRKNAQEAHEAIRPTSVMRTPDEVAPYLERDQLRLYRLIWERTVSCQMAPSVSEVTT 393 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALR-KGDEDRILPAVNKGDALTLVELTPA-QHF 470 L + G + L+A G ++ FDG+ +M G++ + +P + +G LTL+ + A QHF Sbjct: 394 LIINGGPYELRASGSVVNFDGFLTLMDKKELAGEKTKKVPHLKEGTPLTLISVDDAIQHF 453 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PPA F+EA+LVKELE++GIGRPSTYA+II TI RGYV E ++ ++G + L Sbjct: 454 TEPPAYFTEATLVKELEEKGIGRPSTYATIIQTILSRGYVAKEAKKVMPTELGMTTIELL 513 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 + F L++ F+A MEN LD ++ H+ + + VL F+ F ++L+ A++ E ++P Sbjct: 514 TQYFPNLIDVPFSAHMENELDAISEHKTKKETVLKEFYGPFEKELEIADR---EIPVKPQ 570 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 +++++ + C CGR M ++T G FL C G+ C+ N P E + V Sbjct: 571 EVIVSDVKCEKCGRMMVVKTGRHGKFLACPGFP-----ECR---NTKPYYEKIGV----- 617 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710 CP CG + R + C + P C +D PI E Sbjct: 618 ----------ACPLCGHDLIVRKTKTGRTFYGCSHYPEC----------HFTSWDKPINE 657 Query: 711 -CEKCGSEMHLKMGRFGKYM-ACTNEECKNT 739 C CG M + R GK + C+N EC N+ Sbjct: 658 TCPLCGHIMLEAVQRGGKVVHHCSNPECPNS 688 >UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_ACIBL Length = 853 Score = 538 bits (1385), Expect = e-151, Method: Compositional matrix adjust. Identities = 331/833 (39%), Positives = 457/833 (54%), Gaps = 132/833 (15%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI KYLG Y V++S+GHI+DLP G Sbjct: 1 MAKGLVIVESPAKAKTIQKYLGKGYEVEASLGHIKDLPKKG------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD +N++ Y V+PGKEKVV++LK+LA+ AD IYLA D DREGEAIA Sbjct: 42 ----------LGVDIENNFDTEYVVIPGKEKVVAKLKKLAKDADAIYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDAR---------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFM 171 HL E +G D + + RV FNEITK A+++AF KP E++ + V+AQQ RR + Sbjct: 92 AHLAEELGDGDGKKKKKTDSKPFYRVTFNEITKKAVQEAFAKPREIDRNLVDAQQTRRIL 151 Query: 172 DRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 DR+VG+ VSPLLW K+ RGLSAGRVQ+VA+RL+VEREREIKAFV +E+W +DA Sbjct: 152 DRLVGFQVSPLLWDKVRRGLSAGRVQTVALRLIVEREREIKAFVSKEYWTIDAHLHGQKP 211 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + T + + N+E+++ V L+ A +SV +++ APF TS QQ Sbjct: 212 PDFDARFTGIDGEKLEVGNEEESKKIVDQLDNAEWSVRSVDNRERRRNAAAPFTTSKFQQ 271 Query: 292 AASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 AS +LG VK+ MM+AQ LYE G ITYMRTDST +S +A+ VR I + Sbjct: 272 DASRKLGMSVKRAMMIAQHLYEGVELGEEGTVGLITYMRTDSTRVSNEALTEVRELIGTS 331 Query: 343 FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 +G ++LPESPN Y K+++Q AHEAIRPS V + LK ++ D K+Y+LIW++FVA Sbjct: 332 YGPQFLPESPNVYKQKKDAQGAHEAIRPSSVAHTPDDLKAYLKDDEMKVYKLIWQRFVAS 391 Query: 402 QMTPAKYDSTTLTVGAG---DFRLKARGRILRFDGWTKVMPALRKGDED------RILPA 452 QM PA +D TT+ + A + + G +L+F+G+ KV ++G ++ LP Sbjct: 392 QMAPAVFDQTTVDIDAKADRTYNFRVTGSVLKFEGFLKVYEESKEGKDEEDDALKHKLPP 451 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 + +G LTL + P QHFT+PP R++EASLVKELE++GIGRPSTYA+I+STIQDRGYV+ Sbjct: 452 LVEGQTLTLKAIKPEQHFTEPPPRYNEASLVKELEEQGIGRPSTYAAILSTIQDRGYVQK 511 Query: 513 ENRR---FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 R F+ ++G +VTD L NF+++ + FT++ME LD+V + + +W L F+ Sbjct: 512 TPGRGGKFFPTEIGMVVTDLLVANFKDIFDTKFTSRMEEELDEVEDGQKKWTDTLKEFYD 571 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 F LD A+K E T C CG + I+ G F CS Y Sbjct: 572 KFETNLDYAQKHMENIKRMEKP---TDEKCERCGSPLVIKWGKHGSFYACSSYDKKDPNS 628 Query: 630 CKTT----INLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGN 685 C T I+L P+ + +V E E E C CG M Sbjct: 629 CTFTKENPIDL-PDLDTADVQETEQEEY--------CENCGRGM---------------- 663 Query: 686 NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILR 744 LK GRFG++MACT ECK TR++ + Sbjct: 664 ---------------------------------VLKRGRFGQFMACTGYPECKTTRRLDQ 690 Query: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 ++ VPL E C + VLR G G F++ + +P+ + + V Sbjct: 691 AKKIP-----DVPLDE-KCPECTRPLVLRHGRFGEFVSCSGYPECKWIKQNFV 737 >UniRef50_B0MRI8 DNA topoisomerase n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MRI8_9FIRM Length = 713 Score = 534 bits (1376), Expect = e-150, Method: Compositional matrix adjust. Identities = 308/765 (40%), Positives = 429/765 (56%), Gaps = 89/765 (11%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKAKTI KYLG DY V +SVGHIRDLP S Sbjct: 18 LVIVESPAKAKTIEKYLGKDYSVVASVGHIRDLPKS------------------------ 53 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 ++GVD +N+E YE K ++ ELK+ A+ +D +YLATD DREGEAI+WHL Sbjct: 54 -----KLGVDVDNNFEPKYENKKDKAALIKELKKDAKASDIVYLATDPDREGEAISWHLA 108 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 V+G RV F+EITK+ I + P L++D +NAQQARR +DR+VGY +SP LW Sbjct: 109 HVLGISPDAPVRVTFSEITKSGIEAGMSHPRTLDMDLINAQQARRILDRIVGYKLSPFLW 168 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-EALALQVTHQND 243 KK+ RGLSAGRVQSVAVRL+V+RE+EI++F +E+W +DA + S A ++T Sbjct: 169 KKVRRGLSAGRVQSVAVRLIVDREQEIESFEAQEYWSIDAKLLSASSRRAFPAKLTEVKG 228 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 + F+ +NKE+T +++LE + + ++ P PF TSTLQQ AS +L F ++ Sbjct: 229 EKFKALNKEETDKVLAMLENGEFIITNIKNSTRKKTPAPPFTTSTLQQEASRKLSFNARR 288 Query: 304 TMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 TM AQ LYE G ITYMRTDS +S +A I +GK+YLP P Sbjct: 289 TMKAAQELYEGVEIPDMGAVGIITYMRTDSLRISDEAKAAAAQMIESTYGKEYLPSKPRV 348 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 + SK N+Q+AHEAIRP+ + + E +K + D KLY+LIW +F+A QM D+ + Sbjct: 349 FKSKNNAQDAHEAIRPTIITLTPEKVKSALSGDQYKLYKLIWERFMASQMENQLLDTKAV 408 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR--ILPAVNKGDALTLVELTPAQHFT 471 + G+ KA G ++FDG+TK+ + DE+ LPA+ G+ L + ELT QHFT Sbjct: 409 DITCGECLFKANGYTVKFDGFTKLYEESKDNDEEEGGALPALEVGEKLKVKELTGNQHFT 468 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 +PP R++EASL+K LE+ GIGRPSTYA I+TI DR YV E ++ +G ++TD ++ Sbjct: 469 QPPPRYTEASLIKALEENGIGRPSTYAPTIATILDRHYVEREAKQLKPTSLGIVITDLMK 528 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR-PN 590 +F +++ FTAQME+ LD++ +A+W VL F++ F + L KAEKD E ++ P+ Sbjct: 529 GHFERIVDAKFTAQMESDLDKIEAGKADWVDVLGKFYTGFDKMLTKAEKDMEGKRVKIPD 588 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 + T I C CG+ M I+ G FLGCSG+ CK T +V E L Sbjct: 589 EP--TDIVCDKCGKPMVIKIGPYGKFLGCSGFP-----ECKNTKRIVNETGGL------- 634 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710 CP CG M + + C N C+ +D P+ + Sbjct: 635 -----------CPHCGGKMLAKKSKKGKPFFGCENYKDCN----------FMTWDTPLED 673 Query: 711 -CEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKED 754 C KCGS + K+G+ G+ + C + C G V P ED Sbjct: 674 KCPKCGSTLFKKVGKQGQ-VYCAKDGC---------GYVRPADED 708 >UniRef50_C1SMY2 DNA topoisomerase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SMY2_9BACT Length = 782 Score = 530 bits (1366), Expect = e-149, Method: Compositional matrix adjust. Identities = 320/826 (38%), Positives = 460/826 (55%), Gaps = 79/826 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKA+TI KYLG ++ V +SVGH++DLP S Sbjct: 1 MPKNLVIVESPAKARTIEKYLGRNFKVLASVGHVKDLPASS------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD +++E Y ++ GK+K++ ELK++A A++IYLA D DREGEAIA Sbjct: 42 ----------LGVDLDNDFEPKYSIIRGKKKIIDELKKVANSAENIYLAPDPDREGEAIA 91 Query: 121 WHLREVIG-GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ E +G + + RV+FNEITK I G +N +R NAQQARR +DR+VGY+V Sbjct: 92 WHIAEELGKKNKGKIYRVLFNEITKKGIEDGIKNTGPINENRTNAQQARRILDRLVGYLV 151 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SPLLWK + GLSAGRVQSVA+RL+VERE EI+ F PEE+W +D + L ++ Sbjct: 152 SPLLWKSLKYGLSAGRVQSVALRLLVEREEEIEKFKPEEYWLIDVTFKGGQKALLKARLE 211 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 +N K +R N E+ +A ++ L+ Y+V E K + PFITS LQQ A+ +L F Sbjct: 212 KKNGKKYRVPNGEEAEAVLAALKAGSYNVNEVIRKEVFERAPLPFITSKLQQEAARKLSF 271 Query: 300 GVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 K+TMM+AQRLYE G ITYMRTDST +S DA N RGYI +GK++L + Sbjct: 272 SAKRTMMLAQRLYEGIELGSEGPVGLITYMRTDSTRVSPDATNEARGYIEKQYGKEFLSK 331 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 + K+N Q+AHEAIRP+ V + ES+K ++ D KLY+LIW +FV+ M A YD Sbjct: 332 GVKGGSKKKNVQDAHEAIRPTSVAITPESVKKILDTDQYKLYKLIWDRFVSSNMADAVYD 391 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR-----ILPAVNKGDALTLVEL 464 T+ + G + LK++G++++F G+ + + DE + ++ V +G+ L + Sbjct: 392 QNTIHIANGPYLLKSQGKVMKFPGFQTLY--IEGVDESKEKDQEVIFDVKEGETLNPEKH 449 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 Q FT+PPAR+SEA+LVK LE GIGRPSTYASIIST+ DR Y +E +RF ++G Sbjct: 450 DSKQMFTQPPARYSEATLVKTLEAEGIGRPSTYASIISTLIDREYANMEEKRFKPTELGR 509 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 +V L NF + FTA ME LD V E WK VL F++ F +L+KAEK Sbjct: 510 VVCSLLIANFDRIFEPKFTAGMEEDLDSVEAGELTWKGVLRDFYAKFKPELEKAEK---- 565 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV-PENEVL 643 + + + + CP C + + I+ G F+ C+ Y CK T N E+ Sbjct: 566 ---QFSANLKIEMKCPVCEKDLTIKYGRNGNFVACTSYP-----ECKFTSNYERLEDGSF 617 Query: 644 NVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR--KLHVCGNNPTCDGYE----IEEG 697 ++ E+ + + + C KCG + + R ++ C P C + + +G Sbjct: 618 KLVPKEEDKPSGI----ECEKCGKEL---VFKKTRFGEVLACPGYPECKNIKNYVTLPDG 670 Query: 698 EFRIKGYDGPI-VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRN--GEVAPPKE 753 E +I I C KC + + +K GR G ++ C N +C T + N G++ PK Sbjct: 671 EIKILAAGEEIGTPCPKCEAGLTIKGGRNGMFIGCKNYPDCDFTANMEVNEQGDII-PKY 729 Query: 754 DPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEE 799 D V + CEK VL+ G F A +P+ + ++ +V E Sbjct: 730 DKVD-ENVKCEKCGKPMVLKKSRRGKFFACTGYPECKNAKSTIVLE 774 >UniRef50_D0LR99 DNA topoisomerase n=169 Tax=cellular organisms RepID=D0LR99_HALO1 Length = 894 Score = 529 bits (1362), Expect = e-148, Method: Compositional matrix adjust. Identities = 313/765 (40%), Positives = 421/765 (55%), Gaps = 94/765 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GKALV+VESPAKA+TI KYLG DY VK+SVGHI+DLP Sbjct: 136 GKALVVVESPAKARTIGKYLGPDYTVKASVGHIKDLPK---------------------- 173 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 N++GVD +E Y V+ K+KV+SE+++ AE+ + +YLA D DREGEAIAW Sbjct: 174 -------NKIGVDVDQAFEPEYVVISDKKKVISEIRKAAERVEEVYLAPDPDREGEAIAW 226 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ E I + R++ NEITK + A P L+ ++ +AQQARR +DR+VGY +SP Sbjct: 227 HIAEEIKPINDNIKRILINEITKKGVNHAIANPTVLDTNKTDAQQARRILDRLVGYEISP 286 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 +LWKK+ RGLSAGRVQSVAVRL+VER++EI AF PEE+W VD + P A ++ Sbjct: 287 ILWKKVRRGLSAGRVQSVAVRLLVERDKEIAAFTPEEYWSVDVDCSAPEPPPFAAKIHRW 346 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + P + Q L +V + E K +P PFITS LQQ AS +L F Sbjct: 347 DGAKAEPKTEAQATEIADELRAQAAAVAKVERKERRRRPQPPFITSKLQQEASRKLRFSA 406 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 K+TM +AQRLYE G ITYMRTDST +S DA+ +R +I +G ++LP P Sbjct: 407 KRTMALAQRLYEGIELGSEGPLGLITYMRTDSTRISDDALAALRTHIQGTYGPEFLPAKP 466 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ------KLYQLIWRQFVACQMTPA 406 + Y S + +Q+AHEAIRP+ + E + A + KLY LIW++FVA QM PA Sbjct: 467 HTYKSPKRAQDAHEAIRPTTLEYPPERVAKALAGHREGKELVKLYTLIWQRFVASQMAPA 526 Query: 407 KYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE--------DRILPAVNKGDA 458 YD T + + G L+A G++++F G+ V A DE D++LP + +G A Sbjct: 527 VYDQTAVDIQCGRAILRASGQVMKFPGFLSVYRAQETDDEKAETAADQDKLLPHLEEGMA 586 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFY 518 + + P QHFT+PP RF+EASLVKELE+RGIGRPSTYASIISTI DRGYV RF+ Sbjct: 587 IHFDAIRPEQHFTQPPPRFTEASLVKELEERGIGRPSTYASIISTITDRGYVERREARFF 646 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 ++G IV D L E+F ++M+ DFTA ME LD+V E +W+ +L F+ F ++ A Sbjct: 647 PTELGAIVNDLLVESFPKIMDVDFTAAMEADLDKVEEGERDWRELLGGFYEPFRGNIEHA 706 Query: 579 EKDPEEGGMR--PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 +++ MR + + T C CG M I+ G FL C Y P R IN Sbjct: 707 KEN-----MRDVKREEIPTDHVCEKCGAPMVIKWGRNGSFLACQAY---PDCRNTKEINR 758 Query: 637 VPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR--KLHVCGNNPTCDGYEI 694 P+ V E ET C +CG M ++ R C P C + Sbjct: 759 NPDGSFEIVPEQTTDET--------CSECGAPM---VVKRGRFGAFLACSTYPECKNTQ- 806 Query: 695 EEGEFRIKGYDGPI---VECEK--CGSEMHLKMGRFGK-YMACTN 733 PI V+C K CG + K R GK + C+N Sbjct: 807 ------------PISLGVDCPKDGCGGFLTEKRSRRGKPFYGCSN 839 Score = 57.0 bits (136), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 31/88 (35%), Positives = 50/88 (56%), Gaps = 10/88 (11%) Query: 711 CEKCGSEMHLKMGRFGKYMAC-TNEECKNTRKILRNG----EVAPPKEDPVPLPELPCEK 765 CEKCG+ M +K GR G ++AC +C+NT++I RN E+ P + + C + Sbjct: 724 CEKCGAPMVIKWGRNGSFLACQAYPDCRNTKEINRNPDGSFEIVPEQ-----TTDETCSE 778 Query: 766 SDAYFVLRDGAAGVFLAANTFPKSRETR 793 A V++ G G FLA +T+P+ + T+ Sbjct: 779 CGAPMVVKRGRFGAFLACSTYPECKNTQ 806 >UniRef50_B1GYR4 DNA topoisomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYR4_UNCTG Length = 740 Score = 529 bits (1362), Expect = e-148, Method: Compositional matrix adjust. Identities = 312/770 (40%), Positives = 440/770 (57%), Gaps = 76/770 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP K KTI+K LG D+ VKSS GHIRDLP Sbjct: 1 MSKYLVIVESPTKEKTISKILGKDFTVKSSYGHIRDLPK--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 N++G+D N++ Y+ + +K++S+LK+ AE +D IYLATD DREGEAIA Sbjct: 40 --------NKLGIDIEDNFKPTYKNISKSKKLISDLKKKAENSDKIYLATDFDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+E + +++ SR+ F+EIT AI +A P L++ VN+QQARR +DR+VGY +S Sbjct: 92 WHLKEALKLPESKISRITFHEITTEAILKAVKHPRNLDMKLVNSQQARRILDRLVGYKLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA------STTTPSGEAL 234 PLLWKK+ GLSAGRVQSVAV L+ +RE E K+F+P E+W ++A TTP L Sbjct: 152 PLLWKKVKPGLSAGRVQSVAVMLICKREEEFKSFIPVEYWSIEAELSKLEENTTPFKSLL 211 Query: 235 ALQVTHQNDKPFRPV---NKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 +ND F + NKEQ+ + LE A+Y V E K P AP+ TST+QQ Sbjct: 212 F----SKNDVKFDKLSVKNKEQSDETLKELEGAKYIVKSVETKQRKRSPYAPYTTSTMQQ 267 Query: 292 AASTRLGFGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDN 342 AS +LGF KTM AQ+LYE AG ITYMRTDS N+++ + +I + Sbjct: 268 DASRKLGFSASKTMSAAQKLYEGVHIGNSTNAGLITYMRTDSLNIAKSVQSETLKFIEYS 327 Query: 343 FGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVA 400 +G +LP+ P Y +K + +QEAHEAIRP N + +K + D KLY LIW++F+A Sbjct: 328 YGSNFLPKIPRIYKTKTKGAQEAHEAIRPISPNRIPSEVKQYLSEDELKLYNLIWKRFLA 387 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALT 460 QM A Y++ T + A D+ K+ L FDG+ KV A E + LP++ G+ L Sbjct: 388 SQMADAVYNTVTAEILAKDYLFKSLESTLIFDGFLKVYNADDDEKETKKLPSLKSGEQLN 447 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 L+ L P QHFT+PP + ASL+K LE+ GIGRPSTYA I TI DR YV ++ ++F Sbjct: 448 LLRLLPLQHFTEPPPLYDVASLIKALEEHGIGRPSTYAPTIKTILDRLYVHLDGKKFVPT 507 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK 580 G +V + L+++F ++N +FTA +E LD++A +A W+ VL F+ F + L +AEK Sbjct: 508 NRGIVVNNVLKDHFGNIINVEFTASVEEKLDKIAEDKAVWQNVLKDFYKPFKKDLSEAEK 567 Query: 581 DPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEN 640 + ++ ++ Q TS CP CG+ M IR + FLGCSGY CKTT++L + Sbjct: 568 NLQKQKVQAQQ---TSEICPNCGKNMVIRYSRKVQFLGCSGYP-----ECKTTLSLDKDG 619 Query: 641 EVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDG-YEIEEGEF 699 ++ D +C KCG+ + ++ C N P C Y I + Sbjct: 620 KIAAAPRETDM---------KCDKCGSHLIKKTGFAGKQYLSCKNYPECKTLYNINKDGN 670 Query: 700 RIKGYDGP---IVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRN 745 +I Y P ++C KCGSEM K+G+ G ++ C+ +C+N + I N Sbjct: 671 KI-IYPEPEHTDIKCNKCGSEMLKKIGKRGPFLTCSAFPKCRNLQWIKTN 719 Score = 54.3 bits (129), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 44/141 (31%), Positives = 63/141 (44%), Gaps = 24/141 (17%) Query: 662 CPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI--------VECEK 713 CP CG M +I RK+ G C GY + + DG I ++C+K Sbjct: 583 CPNCGKNM---VIRYSRKVQFLG----CSGYPECKTTLSLDK-DGKIAAAPRETDMKCDK 634 Query: 714 CGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGE--VAPPKEDPVPLPELPCEKSDAY 769 CGS + K G GK Y++C N ECK I ++G + P E ++ C K + Sbjct: 635 CGSHLIKKTGFAGKQYLSCKNYPECKTLYNINKDGNKIIYPEPEHT----DIKCNKCGSE 690 Query: 770 FVLRDGAAGVFLAANTFPKSR 790 + + G G FL + FPK R Sbjct: 691 MLKKIGKRGPFLTCSAFPKCR 711 >UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=TOP1_STAHJ Length = 689 Score = 519 bits (1336), Expect = e-145, Method: Compositional matrix adjust. Identities = 294/752 (39%), Positives = 428/752 (56%), Gaps = 91/752 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG Y V +S+GH+RDLP S Sbjct: 1 MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRS-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +MGVD N+E Y + GK VV +LK+ A+KA +++LA+D DREGEAIA Sbjct: 41 ---------QMGVDVEDNYEPKYITIRGKGPVVKDLKKYAKKAKNVFLASDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ DD++ +RVVFNEITK+A++++F P + +D V+AQQARR +DR+VGY +S Sbjct: 92 WHLSKILELDDSKENRVVFNEITKDAVKESFKHPRGIEMDLVDAQQARRILDRLVGYNIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ +GLSAGRVQSVA+RLV++RE EI+ F PEE+W ++ + A + H Sbjct: 152 PVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKSKFTA-KFLH 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 +KPF+ K+ + + L+ ++ + K T P PF TSTLQQ A+ +L F Sbjct: 211 YKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEKTRNPANPFTTSTLQQEAARKLNFK 270 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 +KTMM+AQ+LYE G ITYMRTDST +SQ A + + YI D +GK YL S Sbjct: 271 ARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISQTAKDEAKQYIEDKYGKDYL--S 328 Query: 352 PNQYASKENSQEAHEAIRP-SDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDS 410 K+ Q+AHEAIRP S + E + D +LY+LIW +FVA QM PA D+ Sbjct: 329 NRTAKGKQGDQDAHEAIRPTSTLRTPYEMKAYLTRDQHRLYKLIWERFVASQMAPAILDT 388 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPAL---RKGDEDRILPAVNKGDALTLVELTPA 467 L V + + +A G+ ++F G+ + + +++ LP ++KGD +T ++ PA Sbjct: 389 VALDVTQNNIKFRANGQTIKFKGFMTLYVEAKDDKDNEKENKLPNLSKGDEVTATQIEPA 448 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFT+PP R++EA LVK LE+ IGRPSTYA I TIQ R YV++E++RF ++GEIV Sbjct: 449 QHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVY 508 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 +++++ F E+++ +FT ME LD++A + W+ V+D+F+ F +++AE++ E+ + Sbjct: 509 EQVKDYFPEIIDVEFTVNMETLLDKIAEGDIGWRKVIDNFYGSFKLDVERAEEEMEKVEI 568 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 + DC CG M I+ G F+ CS + C+ T +V V Sbjct: 569 KDEP---AGEDCEVCGSPMVIKMGRYGKFMACSNFP-----DCRNTKAIVKTIGVT---- 616 Query: 648 GEDAETNALRAKRRCPKCGTAMDSYLIDPKRK----LHVCGNNPTCDGYEIEEGEFRIKG 703 CPKC D +++ K K + C N P CD Sbjct: 617 --------------CPKCK---DGDVVERKSKKNRLFYGCSNYPECD----------FIS 649 Query: 704 YDGPI-VECEKCGSE-MHLKMGRFGKYMACTN 733 +D P+ +C KC M K GR + + C+N Sbjct: 650 WDKPVGRDCPKCNHYLMEHKKGRSSQVI-CSN 680 >UniRef50_Q01N68 DNA topoisomerase n=7 Tax=Bacteria RepID=Q01N68_SOLUE Length = 934 Score = 516 bits (1330), Expect = e-144, Method: Compositional matrix adjust. Identities = 288/647 (44%), Positives = 400/647 (61%), Gaps = 59/647 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M KALVIVESPAKAKTINKYLG YVVK+S+GHI+DLP K Sbjct: 1 MPKALVIVESPAKAKTINKYLGKQYVVKASLGHIKDLP---------------------K 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +D + VD H +E YE++ GK+K++ EL+ A+ D IYLA D DREGEAI Sbjct: 40 RD--------LAVDVEHGFEPRYEIIEGKKKLMGELRSAAKGVDQIYLAADPDREGEAIC 91 Query: 121 WHLREVIGG--DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 +HL+E + D + RV+FNEITK A+ +AF KP ++N + V+AQQARR +DR+VGY Sbjct: 92 FHLQEELRSKKDGPAFFRVMFNEITKKAVEKAFEKPLQVNTNLVDAQQARRVLDRLVGYK 151 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +SPLLW K+ RGLSAGRVQ+VA+R++VEREREI+AF +E+W VD + L+ ++ Sbjct: 152 ISPLLWDKVRRGLSAGRVQTVALRVIVEREREIRAFQKKEYWTVDVDLLARTAPVLSTRL 211 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 ND+ N++ T + V+ L Y V + P APFITSTLQQ +S +L Sbjct: 212 IKANDETPELPNQQTTDSLVAQLSGVDYIVKSVATREKRRNPVAPFITSTLQQDSSRKLR 271 Query: 299 FGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 F VK+TMM+AQRLYE G ITYMRTDST S DA++ VR YI + +G +LP Sbjct: 272 FSVKRTMMLAQRLYEGIEIGRDGAVGLITYMRTDSTRTSDDAISDVRHYIGERYGAPFLP 331 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKY 408 +PN Y SK+ +Q+AHEAIRP+ + E ++ + D KLY+LIW +FVA QM PA + Sbjct: 332 PAPNVYKSKKEAQDAHEAIRPTSMAYSPEVVEQYLPEDEMKLYRLIWNRFVASQMMPALF 391 Query: 409 DSTTLTVGAG-----DFRLKARGRILRFDGWTKVMPALR-KGDED-----RILPAVNKGD 457 D TT+ V A ++ +A G + +FDG+ KV + + DED LP V +G+ Sbjct: 392 DQTTIDVSAKAANGVEYTFRATGSVPKFDGFLKVYQEGKDQTDEDDEELKHRLPLVTEGE 451 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L L + P QHFT+PP R++EA+LVK LE G+GRPSTYA+I+STIQ+R YV E RF Sbjct: 452 VLRLEAIRPEQHFTEPPPRYNEATLVKRLEADGVGRPSTYATILSTIQEREYVNKEAGRF 511 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 ++G +VTD L E+F ++ + +TA+ME LD++ + +W+A + F+ F + L Sbjct: 512 TPTELGMVVTDLLLESFDDIFDVKYTARMEEELDEIEEGKLDWRAAMSEFYGRFDKDLKH 571 Query: 578 AEKDPEEGGM--RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGY 622 AE+ + +P ++ C CGR + I+ G F+ C+GY Sbjct: 572 AEEHMTDIKRMEKPTDLI-----CEKCGRPLVIKWGKHGSFIACTGY 613 Score = 52.4 bits (124), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 30/81 (37%), Positives = 42/81 (51%), Gaps = 8/81 (9%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 CE CG M LK GRFG + AC+ +CK TR+I ++ VPL E C + D Sbjct: 769 CENCGRPMVLKKGRFGTFFACSEYPDCKTTRQI------GGTQKKDVPLDE-KCPQCDNN 821 Query: 770 FVLRDGAAGVFLAANTFPKSR 790 V++ G G F A + +P + Sbjct: 822 LVMKYGRFGEFTACSNYPTCK 842 >UniRef50_A7NJW2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A7NJW2_ROSCS Length = 836 Score = 515 bits (1327), Expect = e-144, Method: Compositional matrix adjust. Identities = 315/781 (40%), Positives = 442/781 (56%), Gaps = 100/781 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 MG+ LVIVESPAKA+TI KYLGS Y V++S+GH+RDLP S Sbjct: 1 MGEKLVIVESPAKARTIQKYLGSGYRVEASMGHVRDLPKSN------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD N+ YE+ PGKEK+++ L++ +AD +YLATD DREGEAIA Sbjct: 42 ----------LGVDLEANFAPVYEISPGKEKIIAALRKSIRQADAVYLATDPDREGEAIA 91 Query: 121 WHLREV--IGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 WH+ E I D Y RVVF EIT A+R A P +++ V+AQQARR +DR+VGY Sbjct: 92 WHITEAAKIPRDKPVY-RVVFTEITPGAVRSAMASPRDIDRRLVDAQQARRVLDRLVGYK 150 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE------ 232 +SPLLW+K+ RGLSAGRVQSVAVRL+VEREREI+AFVP+E+W ++A + Sbjct: 151 LSPLLWEKVRRGLSAGRVQSVAVRLIVEREREIEAFVPQEYWTIEADLLKQNASDSQRDA 210 Query: 233 --ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 A+ ++ + + + F +Q QA ++ LE A Y V + + P PF TSTLQ Sbjct: 211 FRAMLIERSGKKLEKFDIGASDQAQAIIADLEGAAYIVRKVTRRDKRRSPAPPFTTSTLQ 270 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA----------GYITYMRTDSTNLSQDAVNMVRGYIS 340 Q A +LGF K+TM +AQ+LYE G ITYMRTDS N+S++A R I Sbjct: 271 QEAGRKLGFSAKRTMAVAQQLYEGVDIGGDEGLVGLITYMRTDSVNVSREAQEEARRVIR 330 Query: 341 DNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQF 398 + FG+ YLP P Y +K + +QEAHEAIRP+ E ++ + +D +LY LIW++F Sbjct: 331 ERFGEAYLPAKPPVYKTKAKGAQEAHEAIRPTLSRRTPEQVQPYLTSDQYRLYDLIWKRF 390 Query: 399 VACQMTPAKYDSTTLTVGAG-----------DFRLKARGRILRFDGWTKV-----MPALR 442 VA QM A +DST + +GAG + +A G +L+F G+ V Sbjct: 391 VASQMEAAVFDSTVVDIGAGRDIGGRGAGSDPYTFRATGSVLKFPGFLAVYNVSLDEGEE 450 Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 D +R LP + +G+AL L++L P QHFT+PP RF+EASLVKELE+ GIGRPSTYA IS Sbjct: 451 DEDSERRLPLLEEGEALNLLQLLPVQHFTEPPPRFTEASLVKELERLGIGRPSTYAPTIS 510 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 TI +R YV + +++ +G +VTD L E+F +++Y FT++ME LD +A E EW Sbjct: 511 TIIEREYVELADKKLVPTTLGRVVTDLLVEHFPSIVDYGFTSEMEQQLDDIAEGEKEWAP 570 Query: 563 VLDHFFSDFTQQLDKAEKDPEEGGMR--PNQMVLTSIDCPTCGR-KMGIRTASTGVFLGC 619 VL F+ F Q+L +A++ MR + +LT + CP C + ++ ++ G FL C Sbjct: 571 VLRAFYRPFEQKLAEAQRS-----MRNVKREEILTDLTCPRCNQGQLAVKFGRNGEFLAC 625 Query: 620 SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRK 679 + Y C T + +++ VL DA + + C CG M ++ R Sbjct: 626 NRYP-----ECDFTSDFHRDSDGRIVL---DAPASPETSDVLCDVCGRPM---ILKKSRF 674 Query: 680 LHVCGNNPTCDGYEIEEGEFRI--KGYDGPI-----VECEKCG-SEMHLKMGRFGK-YMA 730 G C GY + R+ +G P+ V C KCG E+ + G+FG+ + Sbjct: 675 GPFLG----CSGYPECKNTRRLDKQGKPAPLPKATGVTCPKCGQGELLERRGKFGRPFFG 730 Query: 731 C 731 C Sbjct: 731 C 731 >UniRef50_C6BUQ9 DNA topoisomerase n=14 Tax=Desulfovibrionales RepID=C6BUQ9_DESAD Length = 800 Score = 515 bits (1326), Expect = e-144, Method: Compositional matrix adjust. Identities = 305/761 (40%), Positives = 444/761 (58%), Gaps = 68/761 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L++VESPAK KTI+K+LG +Y V +SVGH+RDLP Sbjct: 1 MSKDLIVVESPAKVKTISKFLGRNYQVAASVGHVRDLPK--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 N++GV+ ++ Y+V+PGKE VV++LK+ A KADH++LA D DREGEAI Sbjct: 40 --------NKLGVEENGDFTPQYQVIPGKEDVVNKLKKAAAKADHVFLAPDPDREGEAIG 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ +I + SR+ FNEIT A+++A P LN ++QQARR +DR+VGY +S Sbjct: 92 WHVAAIIKEVNENVSRIQFNEITARAVKEALEHPQPLNEQLFDSQQARRILDRLVGYKIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ RG+SAGRVQSVA++LVVERE+ +AF+PEE+W A + + Sbjct: 152 PILWKKVKRGISAGRVQSVALKLVVEREKARRAFIPEEYWLFKAHVEGKNPPPFIADLWK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + K + ++ +A S ++ + + + +K P P+ITSTLQQ A+ RLG+ Sbjct: 212 VDGKKAEIGSADEAEALQSNVKGVPFEITDLTEKERKRNPLPPYITSTLQQDANRRLGYS 271 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 K+TM +AQRLYE ITYMRTDS ++ +A + + I D +G ++ P Sbjct: 272 AKRTMTLAQRLYEGVELGDKGTTALITYMRTDSVRIANEARDTAKKVILDKYGDEFYPAK 331 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 P Y SK +Q+AHEAIRP D +++ E +K + AD K+Y+LIW +F+A QM PA++ Sbjct: 332 PQVYKSKGGAQDAHEAIRPVDASILPEDVKPYLPADQFKVYKLIWNRFIASQMAPARFWD 391 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI-LPAVNKGDALTLVELTPAQH 469 T +T+ A + +++G L F G+ +V + GDE I LP + KG+ L + ++ Q Sbjct: 392 TVVTIQAKNTIWRSKGERLLFPGFMRVTG--KTGDEKLIELPKLEKGEVLKVDKIESEQK 449 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FT+PPAR+SEASLV+ELE++GIGRPSTYASIISTIQDRGYV +E ++F ++G +V+D+ Sbjct: 450 FTQPPARYSEASLVRELEEKGIGRPSTYASIISTIQDRGYVNLEEKKFIPTELGFVVSDQ 509 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 L E+F+ELM+ FTA ME LD VA+ + EW +++ F F L+ A K+ + GG Sbjct: 510 LSEHFKELMDVGFTAAMEKQLDDVADGKIEWTSLMKDFVDGFYPTLETAAKEMKRGGED- 568 Query: 590 NQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV-PENEVLNVLEG 648 T I C C M I+ TG FLGCS Y CK +N E + VLE Sbjct: 569 -----TGITCDKCESPMVIKFGRTGEFLGCSNYP-----ECKNIVNFTRDEKGKIVVLEE 618 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEE--GEFRIKGYDG 706 E E + C KCG+AM + + + C P C + E E +IK + Sbjct: 619 EPPEETGV----TCEKCGSAM-AIKRSNRGEFLGCTGYPDCRNIKNFERDDEGKIKVVET 673 Query: 707 PIVE----CEKC-GSEMHLKMGRFG-KYMACTN-EECKNTR 740 P + C C ++ +K R G +++AC+N +CK+ + Sbjct: 674 PTAQIVGKCPDCDDGDLIIKHARTGSRFIACSNYPDCKHAK 714 Score = 47.8 bits (112), Expect = 0.002, Method: Compositional matrix adjust. Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 3/88 (3%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRN--GEVAPPKEDPVPLPELPCEK 765 + C+KC S M +K GR G+++ C+N ECKN R+ G++ +E+P + CEK Sbjct: 571 ITCDKCESPMVIKFGRTGEFLGCSNYPECKNIVNFTRDEKGKIVVLEEEPPEETGVTCEK 630 Query: 766 SDAYFVLRDGAAGVFLAANTFPKSRETR 793 + ++ G FL +P R + Sbjct: 631 CGSAMAIKRSNRGEFLGCTGYPDCRNIK 658 >UniRef50_Q2FZ32 DNA topoisomerase 1 n=260 Tax=Bacteria RepID=TOP1_STAA8 Length = 689 Score = 514 bits (1325), Expect = e-144, Method: Compositional matrix adjust. Identities = 293/753 (38%), Positives = 432/753 (57%), Gaps = 93/753 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG Y V +S+GH+RDLP S Sbjct: 1 MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRS-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +MGVD N+E Y + GK VV ELK+ A+KA +++LA+D DREGEAIA Sbjct: 41 ---------QMGVDTEDNYEPKYITIRGKGPVVKELKKHAKKAKNVFLASDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ +D++ +RVVFNEITK+A++++F P E+ ++ V+AQQARR +DR+VGY +S Sbjct: 92 WHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMNLVDAQQARRILDRLVGYNIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ +GLSAGRVQSVA+RLV++RE EI+ F PEE+W ++ + A + H Sbjct: 152 PVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKSKFNA-KFLH 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 +KPF+ K+ + + L+ ++ + K T P PF TSTLQQ A+ +L F Sbjct: 211 YKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAARKLNFK 270 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 +KTMM+AQ+LYE G ITYMRTDST +S A + YI+D +G+ Y S Sbjct: 271 ARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKVEAKQYITDKYGESYT--S 328 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 + + K+ Q+AHEAIRPS + +K + D +LY+LIW +FVA QM PA D+ Sbjct: 329 KRKASGKQGDQDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWERFVASQMAPAILDT 388 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALR---KGDEDRILPAVNKGDALTLVELTPA 467 +L + GD + +A G+ ++F G+ + + +++ LP + +GD +T ++ PA Sbjct: 389 VSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLEQGDKVTATQIEPA 448 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QH+T+PP R++EA LVK LE+ IGRPSTYA I TIQ R YV++E++RF ++GEIV Sbjct: 449 QHYTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVH 508 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 ++++E F E+++ +FT ME LD++A + W+ V+D FFS F Q +++AE++ E+ + Sbjct: 509 EQVKEYFPEIIDVEFTVNMETLLDKIAEGDITWRKVIDGFFSSFKQDVERAEEEMEKIEI 568 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 + DC CG M I+ G F+ CS + C+ T +V V Sbjct: 569 KDEP---AGEDCEICGSPMVIKMGRYGKFMACSNFP-----DCRNTKAIVKSIGV----- 615 Query: 648 GEDAETNALRAKRRCPKCGTAMDSYLIDPKRK----LHVCGNNPTCDGYEIEEGEFRIKG 703 +CPKC D +++ K K + C P CD Sbjct: 616 -------------KCPKCN---DGDVVERKSKKNRVFYGCSKYPECD----------FIS 649 Query: 704 YDGPI-VECEKCGSEMHLKMGRFGK--YMACTN 733 +D PI +C KC +L + GK + C+N Sbjct: 650 WDKPIGRDCPKCNQ--YLVENKKGKTTQVICSN 680 Score = 54.3 bits (129), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 23/44 (52%), Positives = 34/44 (77%), Gaps = 1/44 (2%) Query: 710 ECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPK 752 +CE CGS M +KMGR+GK+MAC+N +C+NT+ I+++ V PK Sbjct: 576 DCEICGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKSIGVKCPK 619 >UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5D2W4_PELTS Length = 714 Score = 511 bits (1315), Expect = e-143, Method: Compositional matrix adjust. Identities = 303/755 (40%), Positives = 437/755 (57%), Gaps = 85/755 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI+K+LG + VK+S+GH+RDLP S Sbjct: 1 MSKTLVIVESPAKAKTISKFLGKKFTVKASMGHVRDLPKS-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + GVD + ++ Y + GK ++ +L+ +KAD + +A+D DREGEAIA Sbjct: 41 ---------QFGVDVKNGFKPKYITIRGKGDIIKDLRAAVKKADQVLIASDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+ ++ D+ R+ FNEITK AI++A P ++ +RVNAQQARR +DR+VGY +S Sbjct: 92 WHLQNLLEIDENESCRIEFNEITKQAIQKALQHPRPIDRNRVNAQQARRILDRLVGYNLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLW+KI +GLSAGRVQSVAVRL+ +RE EI++FVPEE+W + AS ++ Sbjct: 152 PLLWRKIKKGLSAGRVQSVAVRLICDREEEIQSFVPEEYWTLVASFVKTGEAPFEGRLIK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 D+ +KE+ Q + L+ ARY+V + K + KP PFITSTLQQ A +L F Sbjct: 212 FRDEKIDIPSKEKMQEVLENLKGARYTVEKVTRKEKSRKPPLPFITSTLQQEAYRKLNFT 271 Query: 301 VKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP-E 350 +KTMM+AQ+LYE +G ITY+RTDST +S A + YI + FG +Y E Sbjct: 272 ARKTMMVAQQLYEGLDLGREGTSGLITYIRTDSTRVSASAREEAQKYIVERFGARYAGRE 331 Query: 351 SP--NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 +P K Q+AHEAIRP+ V E +K+ + D KLY+LIW +F+A QM PA Sbjct: 332 TPPVGPAGRKGKIQDAHEAIRPTSVQREPEQVKEYLTGDQYKLYKLIWSRFLASQMKPAV 391 Query: 408 YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR---KGDEDRILPAVNKGDALTLVEL 464 +D+T + + AG++ +A G +++F G+ KV R + +E+++LP + +G+ + L Sbjct: 392 FDTTNIDIKAGEYLFRANGSVMKFPGFMKVYTESRDDEEKEEEKLLPELKEGEEIEARSL 451 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 TP QHFT+PP R+++ASLV+ LE++GIGRPSTYA I+ TI RGYV EN++F+ ++G Sbjct: 452 TPRQHFTQPPPRYTDASLVRALEEKGIGRPSTYAPIVETILKRGYVVRENKQFFPTELGM 511 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 IV D L+++F+E+++ DFTA ME SLD + E +W VL+ F+ F L+KAE E Sbjct: 512 IVVDLLKKHFKEIIDIDFTAGMEESLDSIEEGELDWIKVLESFYGPFKNTLEKAEN--EI 569 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 G ++ + V T C CGR M ++ G FL C G+ C++T L Sbjct: 570 GHVQVAEEV-TEEKCDRCGRSMVVKVGRYGKFLACPGFP-----ECRSTKPL-------- 615 Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 LE A +CP+C + RK C N P C+ + Sbjct: 616 -LEPVGA---------KCPRCEGELVVRRTKKGRKFLGCSNFPECE----------FVTW 655 Query: 705 DGPI-VECEKCGSEMHLK--MGRFGKYMACTNEEC 736 D P +C +CG M K G+ G ++ C +E+C Sbjct: 656 DQPSGTKCPECGGLMVEKKNAGKKG-FLQCVSEDC 689 >UniRef50_Q2LT40 DNA topoisomerase n=2 Tax=Bacteria RepID=Q2LT40_SYNAS Length = 769 Score = 509 bits (1310), Expect = e-142, Method: Compositional matrix adjust. Identities = 321/817 (39%), Positives = 440/817 (53%), Gaps = 136/817 (16%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M +L+IVESP K KT+ KYLG+DY V +S GHI+DLP KK+ Sbjct: 1 MPDSLIIVESPTKVKTLKKYLGADYEVLASKGHIKDLP------KKT------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +G+DP + ++ Y V+ K+KV+++LK+ A+ I+LA D DREGEAIA Sbjct: 42 ----------LGIDPQNEFQPTYSVIDDKKKVIADLKKAAKNVSRIFLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ E I + RV+FN++TKN I A N PG+L+ ++ AQQ RR +DR+VGY +S Sbjct: 92 WHIAEEIKAKNKEIYRVLFNDLTKNTILDAINHPGKLDFNKYEAQQTRRILDRLVGYQIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS---TTTPSGEALALQ 237 P+LW+K+ RGLSAGRVQSVAVR++ +RE EIK F+PEE+W + T P EA ++ Sbjct: 152 PILWEKVKRGLSAGRVQSVAVRMICDREEEIKRFIPEEYWNISVQLKGVTPPPFEARLIK 211 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLE-------------------KARYSVLEREDKPTTS 278 +T + K N+ Q VS L + ++ V + E K Sbjct: 212 ITGKKAK---VKNEAQANEIVSRLSGGVKSGSKPTINLSEDRDLQPQFVVSKLEKKEVKK 268 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQ 329 + PF TS LQQ AS L F KKTM AQ+LYE G ITYMRTDS +++ Sbjct: 269 ESLPPFTTSKLQQEASRLLRFSAKKTMATAQKLYEGIELGEEGPVGLITYMRTDSVRIAE 328 Query: 330 DAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQ 388 DA+ VR YI +N+ +LP + SK +Q+AHEAIRPS +N + +K + AD Sbjct: 329 DALKEVRSYIRENYDPPFLPAKARFFKSKGKTQDAHEAIRPSSMNYNPQKIKHFLSADQF 388 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED- 447 +LYQLIW +FVA QM PA YD TT+ V A + +A+G IL+F G+T V +G ED Sbjct: 389 RLYQLIWNRFVASQMNPALYDQTTVEVSADFYTFRAQGAILKFPGYTIVY---TEGKEDK 445 Query: 448 ---------RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYA 498 +ILP +N+G+ LTL+++TP Q FT+PP RFSEASLV+ELE++GIGRPSTYA Sbjct: 446 EQNEEMESGKILPDLNEGERLTLLKITPEQKFTQPPPRFSEASLVRELEEQGIGRPSTYA 505 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 +I+STIQDR Y R+E +F+ ++G IVT+ L +NF ++M+ FTA +EN LD + + Sbjct: 506 AILSTIQDRNYARLEQGKFHPTELGTIVTELLVKNFPKVMDVSFTASLENQLDLIEEGKQ 565 Query: 559 EWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG 618 + L F++ F + L KA E + T + C C M I+ G F+ Sbjct: 566 KRIETLQEFYAPFEEDLSKARL---EMKNIKREETPTDLICEKCQSPMVIKWGKNGKFIA 622 Query: 619 CSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRR---CPKCGTAMDSYLID 675 CS Y CK T N+ +GE E +A + CPKCG M LI Sbjct: 623 CSNYPA-----CKNT---------RNIEQGEGVERSAKGGEMTDTVCPKCGKNM---LIK 665 Query: 676 PKR--KLHVCGNNPT-----------------CDGYEIEE------GEFRIKGY------ 704 R + C P CDG IE+ F Y Sbjct: 666 HGRFGRFLGCSGYPDCKHTMPISLGVKCPQEGCDGEIIEKRTKKGRSFFGCSNYPNCTFA 725 Query: 705 --DGPIVE-CEKCGSEMHL-KMGRF-GKYMACTNEEC 736 D PI E C +C S + K R G Y AC N++C Sbjct: 726 VWDKPIPEPCPQCNSPFLVEKYSRTEGSYKACPNKDC 762 Score = 50.8 bits (120), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 2/83 (2%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 CEKC S M +K G+ GK++AC+N CKNTR I GE + + C K Sbjct: 603 CEKCQSPMVIKWGKNGKFIACSNYPACKNTRNI-EQGEGVERSAKGGEMTDTVCPKCGKN 661 Query: 770 FVLRDGAAGVFLAANTFPKSRET 792 +++ G G FL + +P + T Sbjct: 662 MLIKHGRFGRFLGCSGYPDCKHT 684 >UniRef50_C1F6V0 DNA topoisomerase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F6V0_ACIC5 Length = 878 Score = 504 bits (1297), Expect = e-141, Method: Compositional matrix adjust. Identities = 316/788 (40%), Positives = 440/788 (55%), Gaps = 94/788 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+LVIVESPAKAKTINKYLG D+ V++S+GHI+DLP Sbjct: 1 MSKSLVIVESPAKAKTINKYLGKDFQVEASIGHIKDLPK--------------------- 39 Query: 61 KDERGALVNRMGVDPWH-NWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 N++GVD +E V+PGKEKVV +L++LA K D IYLA D DREGEAI Sbjct: 40 --------NKLGVDVEKGTFEPELIVIPGKEKVVDKLRKLATKVDTIYLAPDPDREGEAI 91 Query: 120 AWHLRE----VIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 A HL + V+ +A R+ FNEIT A+ A + ++ + V+AQQ RR +DR+V Sbjct: 92 AAHLEDELKAVVKKPEA-IRRITFNEITPKAVTAALDHARSVDRNLVDAQQTRRVLDRIV 150 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS----- 230 GY +SPLLW K+ RGLSAGRVQ+VA+RL+VERE++IKAF P E+W +DA T Sbjct: 151 GYQISPLLWDKVRRGLSAGRVQTVALRLIVEREQQIKAFKPVEYWTIDAVLKTGGNPQEF 210 Query: 231 --------GEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 GE ++ D P P +++ T V+ L KA +SV E E K A Sbjct: 211 TAHFIGIDGERARVETV---DAPALP-DQKLTDEVVAQLHKADWSVREVERKERKRNAPA 266 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNM 334 PF TS LQQ AS +LGF VK+TM +AQRLYE G ITYMRTDST ++ +A+ Sbjct: 267 PFTTSKLQQDASRQLGFNVKRTMGVAQRLYEGIEIGGDAVGLITYMRTDSTRVAPEAIEA 326 Query: 335 VRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQL 393 VRGYI GK YLP +PN + SK+++Q+AHEAIRP+D N+ + ++ +D Q KLY+L Sbjct: 327 VRGYIQKKVGKDYLPAAPNAFKSKKDAQDAHEAIRPADPNLHPDDIRKYLSDEQYKLYRL 386 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAG-----DFRLKARGRILRFDGWTKVMPALR-KGDED 447 IWR+FVA QM PA +D TT+ + A DFR+ G +++FDG+ +V ++ K D D Sbjct: 387 IWRRFVASQMMPAIFDQTTVEIAARADRRYDFRVT--GSVMKFDGFLRVYEEVKEKKDAD 444 Query: 448 -----RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 LPA+N GD L L L P QH+T+PP R++EASLVKELE+RGIGRPSTYA+II+ Sbjct: 445 DEALANKLPALNNGDRLALSALKPEQHYTEPPPRYNEASLVKELEERGIGRPSTYATIIN 504 Query: 503 TIQDRGYVRV---ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 TIQDR YV+ RF ++G +VT L +NF + + +TA++E LD + + + Sbjct: 505 TIQDREYVQKMGGRTGRFIPTEIGTVVTGLLVKNFPYIFDTKYTARLEEELDDIEDGKER 564 Query: 560 WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC 619 W +L+ F+ F +L A + E+ T C CG + ++ G F C Sbjct: 565 WTDLLNGFYDHFEDELKDAATNMEDIKRMEKP---TDQKCDICGSPLVLKWGKFGSFYAC 621 Query: 620 SGYALPPKERCKTTINLVPENEVL--NVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK 677 S Y K+ C T EN N+ D C + + P Sbjct: 622 SAYDKKKKDGCTFT----KENYEAKPNLAAPSDEAEQEEEYCENCGRVMVLRNG----PW 673 Query: 678 RKLHVC---GNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN- 733 C +P C + + K +C KCG ++ L+ G++G++++C+ Sbjct: 674 GPFMACPGYNEDPPCKTVRRLNQKQQQKPPQPLDEKCPKCGEQLVLRHGQYGEFISCSGY 733 Query: 734 EECKNTRK 741 +CK ++ Sbjct: 734 PKCKYIKQ 741 Score = 44.7 bits (104), Expect = 0.018, Method: Compositional matrix adjust. Identities = 39/137 (28%), Positives = 57/137 (41%), Gaps = 32/137 (23%) Query: 599 CPTCGRKMGIRTASTGVFLGCSGYALPPKERCK----TTINL-VPENEVLNVLEGE---- 649 CP CG ++ +R G F+ CSGY +CK TI + P+ +V ++E + Sbjct: 710 CPKCGEQLVLRHGQYGEFISCSGYP-----KCKYIKQNTIGMKCPQCKVGEIVEKKARRG 764 Query: 650 ------------DAETNALRAKRRCPKCGTAMDSYLIDPKRK---LHVCGNNPTCDGYEI 694 D N R+CP+CG+A YL++ K VC NN E Sbjct: 765 NFFYGCSEYPKCDFTANYKPVDRKCPECGSA---YLMEKTLKSGVYLVCPNNKKPSAEEE 821 Query: 695 EEGEFRIKGYDGPIVEC 711 + + KG G V C Sbjct: 822 TTTKRKKKGDTGEGVSC 838 >UniRef50_A3EPL6 DNA topoisomerase n=2 Tax=Leptospirillum sp. Group II RepID=A3EPL6_9BACT Length = 850 Score = 501 bits (1291), Expect = e-140, Method: Compositional matrix adjust. Identities = 324/823 (39%), Positives = 446/823 (54%), Gaps = 103/823 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L+IVESP KA+T++K LGS Y+VK+SVGH++DLP S Sbjct: 49 GKTLIIVESPTKARTLSKVLGSGYLVKASVGHVKDLPPS--------------------- 87 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 R+G+D H++ +EV P K+KV+SE++ A A +YLA+D DREGEAIA+ Sbjct: 88 --------RLGIDVDHDFALEFEVHPDKKKVLSEIRSEARSAREVYLASDPDREGEAIAY 139 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ + RV+F+E+T+ IR A ++PGE+++ +V AQ+ARR +DR+VGY +SP Sbjct: 140 HIASELEALPVPPKRVLFHELTEGGIRSALSEPGEIDVRKVEAQKARRALDRIVGYTISP 199 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA------STTTPSGEALA 235 LLW ++ RGLSAGRVQSVAVRLV +RE EI FV EE+W +DA P+ + Sbjct: 200 LLWDRVRRGLSAGRVQSVAVRLVCDREDEIARFVREEYWTIDARFRPGDPRVPPTFLSRL 259 Query: 236 LQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 +V+ +KP P + Q AV + + R++V E P P TS LQQ A+ Sbjct: 260 DRVS--GEKPVLPDARTAGQ-AVERIRRERFTVGEITRADKKRNPSPPLTTSRLQQEAAN 316 Query: 296 RLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 RL F KKTM +AQ+LYE G ITYMRTDS +S +A R +I + Sbjct: 317 RLRFSAKKTMTVAQKLYEGVDLPGQGPVGLITYMRTDSVRVSPEAAEAARSWIRQHHPDG 376 Query: 347 YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTP 405 LP Y +++ Q+AHEAIRPSDV ESL+ ++ D +LY LIW+ FV QM+P Sbjct: 377 -LPARAPAYKNRKGIQDAHEAIRPSDVRRTPESLQGSIDPDLFRLYDLIWKSFVESQMSP 435 Query: 406 AKYDSTTLTVGA--GDFRLKARGRILRFDGW-----TKVMP---ALRKGDEDRILPAVNK 455 A Y TT+ V GD +A GR+L+ G+ V P A EDR+LP + Sbjct: 436 ALYLQTTVLVEGDQGDV-FRASGRVLKSPGFLALRGLSVAPEDGAGEGEGEDRLLPPLET 494 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 G+ ++L E+TP QHFT+PP R+SEASL++ELE++GIGRPSTYA+I+STIQDR YV + Sbjct: 495 GEIVSLEEVTPDQHFTEPPPRYSEASLIRELEEKGIGRPSTYATILSTIQDREYVEKKEN 554 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 RFY +G+ V L E+F +LM+ FTA+ME LDQV E ++ V+ F++ F ++ Sbjct: 555 RFYPTDLGKAVNSLLVESFPDLMSVRFTARMEEELDQVEEGERGYRDVVGDFYTPFHHEV 614 Query: 576 DKAEKDPEEGGMRPNQM--VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTT 633 +KA+K GGM + V T + CP C M + G +L CS Y CKTT Sbjct: 615 EKAKK----GGMTNLKKLEVPTDVSCPVCQAPMNRKWGKNGSYLSCSRYP-----ECKTT 665 Query: 634 INLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR--KLHVCGNNPTCDG 691 N EN + ++E AL C C M +I R C P C Sbjct: 666 RNFTEENGQIRIVE------EALPEGEVCHVCQAPM---VIKKGRFGTFLACSRYPECKT 716 Query: 692 Y-----EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRN 745 + E + + P+ C +C S M K GRFG + AC+ ECK TR L Sbjct: 717 TRPWPPKAEASLPAVSPAEAPV--CPECSSPMVQKRGRFGSFWACSRYPECKGTRP-LAT 773 Query: 746 GEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPK 788 G P P C+ V R G G F + +P+ Sbjct: 774 GH---------PCPVKGCK---GELVPRRGKRGTFYGCSRYPE 804 Score = 48.9 bits (115), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 4/87 (4%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILR-NGEVAPPKEDPVPLPELPCEKS 766 V C C + M+ K G+ G Y++C+ ECK TR NG++ E+ +P E+ C Sbjct: 634 VSCPVCQAPMNRKWGKNGSYLSCSRYPECKTTRNFTEENGQIRI-VEEALPEGEV-CHVC 691 Query: 767 DAYFVLRDGAAGVFLAANTFPKSRETR 793 A V++ G G FLA + +P+ + TR Sbjct: 692 QAPMVIKKGRFGTFLACSRYPECKTTR 718 >UniRef50_D1BMP2 DNA topoisomerase n=6 Tax=Firmicutes RepID=D1BMP2_VEIPT Length = 791 Score = 501 bits (1290), Expect = e-140, Method: Compositional matrix adjust. Identities = 298/776 (38%), Positives = 421/776 (54%), Gaps = 95/776 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK LVIVESPAK+KTI K+LG +YVVK+S+GH+RDLP S Sbjct: 72 GKVLVIVESPAKSKTIEKFLGPNYVVKASMGHLRDLPKS--------------------- 110 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++G+D H++ Y L ++KV+ EL A+++ + LATD DREGEAI+W Sbjct: 111 --------QIGIDIEHDFTPRYSNLVTRKKVIDELVSYADESSAVLLATDPDREGEAISW 162 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL ++ D R+ FNEITKNA+ +A + P ++++ V+AQQARR +DR+VGY +SP Sbjct: 163 HLAYILNVDPTSTCRITFNEITKNAVAEALDSPRTIDMNMVDAQQARRVLDRIVGYKLSP 222 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLWKK+ +GLSAGRVQSVAVRL+ EREREI+AFVP+E+W ++ + TP EA ++TH Sbjct: 223 LLWKKVCKGLSAGRVQSVAVRLICEREREIQAFVPQEYWTIEGNFETPKKEAFIAELTHI 282 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + + QA V + V E + + K PF TSTLQQ +L FG Sbjct: 283 KGEKIDITTESDAQAIVDAIGNEDAVVTNIEKRKRSRKAVPPFTTSTLQQDGVRKLNFGA 342 Query: 302 KKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 K+TMM+AQ LYE G ITYMRTDST +S++ M + +I N+G+ Y P P Sbjct: 343 KRTMMIAQHLYEGLEIGSYGHVGLITYMRTDSTRISKEMQAMAKDFILRNYGEDYYPSKP 402 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 N Y SK ++Q+AHEAIRP+ + + + ++ + D KLY LIW +F+A QM P + +ST Sbjct: 403 NVYGSKGSAQDAHEAIRPTSLELTPKMVEPFLSRDELKLYTLIWNRFMASQMAPQQNEST 462 Query: 412 TLTVGA-GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 T+ + D+ KA G + F G++ V +K D + LPA+ K A VE+ P QHF Sbjct: 463 TIELNVKNDYTFKATGSRVIFPGFSAVYEDAKKEDVPQ-LPALKKNYAAHTVEVLPEQHF 521 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP R+SEASL+K LE+ GIGRPSTYA I+ TI R YV N++F ++G +V D L Sbjct: 522 TQPPPRYSEASLIKTLEELGIGRPSTYAPILDTIVSRNYVENTNKQFVPTELGFVVVDFL 581 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE--KDPEEGGMR 588 F +++N FT +E LD +A+ + + VL F+ F Q+L+ A E M Sbjct: 582 ITYFEKIINTGFTRDLEEELDAIASGKDTYVKVLSDFYEVFAQELEDASDVDRIEIASME 641 Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 +++ C C M + G FL CS + CK T + V Sbjct: 642 SDEI------CELCNSPMVYKFGRYGKFLACSNFP-----ECKNTKPITVGTGV------ 684 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPK----RKLHVCGNNPTCDGYEIEEGEFRIKGY 704 CPKC + +++ K R + C P CD F + + Sbjct: 685 ------------TCPKCK---EGEIVERKSRRGRIFYGCNRYPQCD--------FTL--W 719 Query: 705 DGPIVE-CEKCGSEM---HLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPV 756 D P + CE CGS M K G K+ C+NE C + + E+PV Sbjct: 720 DKPTHDFCETCGSIMVEKTYKNGTVKKF--CSNETCPTRPPKKTRKKKSEASEEPV 773 >UniRef50_Q9KA23 DNA topoisomerase 1 n=107 Tax=Bacteria RepID=TOP1_BACHD Length = 690 Score = 501 bits (1290), Expect = e-140, Method: Compositional matrix adjust. Identities = 292/748 (39%), Positives = 410/748 (54%), Gaps = 81/748 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG Y VK+S+GH+RDLP S Sbjct: 1 MADYLVIVESPAKAKTIGKYLGKKYTVKASMGHVRDLPKS-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +MGVD + Y + GK V+ ELK A+K +YLA D DREGEAIA Sbjct: 41 ---------QMGVDIEDEYSPRYITIRGKGPVLKELKSAAKKVKRVYLAADPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL + D+ RVVFNEITK AI+ AF P +N+D V+AQQARR +DR+VGY +S Sbjct: 92 WHLAHSLDIDETSECRVVFNEITKQAIKDAFKSPRPINMDLVDAQQARRVLDRLVGYNIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWKK+ +GLSAGRVQSVAV+++++RE+EI+AF PEE+W + T GE + Sbjct: 152 PLLWKKVKKGLSAGRVQSVAVKMIIDREKEIQAFEPEEYWSIQG-TFALDGEPFEAKFYG 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 N K +++ ++ L+ ++ V + K P +PF TS+LQQ A+ +L F Sbjct: 211 TNGKKVELKSEDDVNNVLAKLKGDQFHVDSVQKKERKRNPVSPFTTSSLQQEAARKLNFR 270 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 KKTMM+AQ+LYE G ITYMRTDST +S A + YI FGK+Y Sbjct: 271 AKKTMMLAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKAETKEYIESKFGKEYAQNG 330 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 + SQ+AHEAIRP+ V +SLK+ + D +LY+LIW + VA QM PA D+ Sbjct: 331 TKAVKKDKKSQDAHEAIRPTSVERDPKSLKEYLSRDQLRLYKLIWERLVASQMAPAIMDT 390 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALR---KGDEDRILPAVNKGDALTLVELTPA 467 T+ + +A G ++F G+ KV K +EDR+LP + +G +T E+ P+ Sbjct: 391 MTVDLSNEGVLFRATGSKVKFPGFMKVYIEGNDEGKKEEDRLLPNLQEGQTVTKEEIEPS 450 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFT+PP R++EA LVK +E+ GIGRPSTYA + TIQ RGYV ++ RRF ++GEIV Sbjct: 451 QHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQKRGYVALDERRFVPTELGEIVL 510 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 + + E F E+++ +FTA+ME+ LD + + +W ++D F+ F ++L AE++ +E + Sbjct: 511 ELMTEFFPEILDVEFTAKMEDDLDSIEEGKQQWIKIIDDFYKGFEERLKVAEEEMKEVEI 570 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 + T C CG +M + G F+ CS + C+ T +V E V Sbjct: 571 KDEP---TGEMCEKCGHEMVYKMGRYGKFMACSNFP-----DCRNTKPIVKEIGV----- 617 Query: 648 GEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL-HVCGNNPTCDGYEIEEGEFRIKGYDG 706 +CPKC KR++ + C P CD +D Sbjct: 618 -------------KCPKCEKGEIVERKSKKRRVFYGCNQYPECD----------FVSWDK 654 Query: 707 PIV-ECEKCGSEMHLKMGRFGKYMACTN 733 PI C KC S + K + + C++ Sbjct: 655 PIARSCPKCSSYLVEKRTKKQVQVQCSS 682 Score = 56.6 bits (135), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 41/98 (41%), Positives = 51/98 (52%), Gaps = 17/98 (17%) Query: 693 EIEEGEFRIKGYDGPIVE-CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAP 750 E E E IK D P E CEKCG EM KMGR+GK+MAC+N +C+NT+ I++ V Sbjct: 562 EEEMKEVEIK--DEPTGEMCEKCGHEMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKC 619 Query: 751 PKEDPVPLPELPCEKSDAYFVLRDGAA-GVFLAANTFP 787 PK CEK + V R VF N +P Sbjct: 620 PK----------CEKGE--IVERKSKKRRVFYGCNQYP 645 >UniRef50_B5YKX8 DNA topoisomerase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YKX8_THEYD Length = 777 Score = 501 bits (1290), Expect = e-140, Method: Compositional matrix adjust. Identities = 305/798 (38%), Positives = 445/798 (55%), Gaps = 107/798 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L+IVESPAKAKTINK +G D+ VK+S+GHI+DLP Sbjct: 5 GKNLIIVESPAKAKTINKIVGKDFQVKASIGHIKDLPE---------------------- 42 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +R+GVD ++ Y ++PGKEK+V ELK A+ A I++ATD DREGEAIA+ Sbjct: 43 -------DRLGVDIEKGFQPDYIIIPGKEKIVKELKDSAKNAQKIFIATDPDREGEAIAY 95 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ E I + + R +F+EIT NA++ A P +++I++V +QQARR +DR+VGY +SP Sbjct: 96 HIAEEIKVPENKVYRAIFHEITPNAVKAAIANPSKIDINKVYSQQARRILDRLVGYNLSP 155 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFW-------------EVDASTTT 228 LWKK+ +GLSAGRVQSVA+R+VVERE+EI F PE +W E+ A+ Sbjct: 156 FLWKKVKKGLSAGRVQSVALRMVVEREKEILIFQPENYWTIVGNFKNDENLKELRANLYK 215 Query: 229 PSGEALALQVTHQNDKP-FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 G+ L + + +K F ++E Q + L+K Y + + E K P PF T+ Sbjct: 216 YKGK---LIIDRKEEKAKFLITDEETAQKIIEELKKLNYILTKVEKKKKKKNPPEPFRTA 272 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYI 339 TLQ AS+ LGF KKTMM+AQ+LYE G ITYMRTDST ++++A + I Sbjct: 273 TLQAQASSTLGFSPKKTMMLAQQLYEGIDIEGTRIGLITYMRTDSTRVAEEAKKWAKNII 332 Query: 340 SDNFGKKYLPESPNQYASKENS--QEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQLIWR 396 NFGK+++ K+ + Q+AHE IRP+ + ES+K Q LY+LIW Sbjct: 333 EKNFGKEFVGNHKIHETKKQKTPIQDAHECIRPTYPDKSPESIKKYLTKEQYSLYKLIWD 392 Query: 397 QFVACQMTPAKYDSTTLTVGAGD--FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVN 454 +F+A QM+PA+ + TT + D + + G ++ F G+ ++ + +ED +LP +N Sbjct: 393 RFLASQMSPAEVEQTTYIIEDLDSIAQFRVTGSVITFPGFL-IIYKDEESEEDTVLPQLN 451 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN 514 + +L + EL +H T+PP R++EA+LVK LE++GIGRPSTYA+I+STIQ+RGYV+ Sbjct: 452 EKTSLKISELEAQKHTTEPPPRYTEATLVKALEEKGIGRPSTYATILSTIQERGYVKKVK 511 Query: 515 RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQ 574 ++ +G +V D LEE F ELM+Y FTA+ME LD+++ +EA+W V++ F+ +F Sbjct: 512 QKLQPTYLGFVVNDLLEEKFPELMDYSFTAKMEEDLDKISLNEAKWNKVIEEFYKEFEND 571 Query: 575 LDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTI 634 LD+A K + ++P + + TS C CG+ M IR + FL CSGY CK T Sbjct: 572 LDQASKISK--VIKPKE-IKTSFKCEKCGKDMVIRWSKGVPFLACSGYP-----ECKNTR 623 Query: 635 NL---------------VPE-NEVLNVLEGEDAE------------TNALRAKRRCPKCG 666 +L P+ L V G+ E T ++ A+ +CP+CG Sbjct: 624 SLNNNENGSTKKTLDKKCPQCGAQLVVRNGKRGEFIACSNYPKCKFTQSITAQVKCPQCG 683 Query: 667 TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL-KMGRF 725 + R C N P C +F + P EC KC S L K R Sbjct: 684 GDILKKQTKKGRTFWACANYPKC--------KFTLSNEPVP-AECPKCKSSYMLKKKDRN 734 Query: 726 G-KYMACTNEECKNTRKI 742 G +++ C N+ CK +I Sbjct: 735 GTEFLICHNKACKGKIEI 752 Score = 50.8 bits (120), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/86 (33%), Positives = 48/86 (55%), Gaps = 6/86 (6%) Query: 710 ECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA 768 +CEKCG +M ++ + ++AC+ ECKNTR L N E K+ + C + A Sbjct: 592 KCEKCGKDMVIRWSKGVPFLACSGYPECKNTRS-LNNNENGSTKKTL----DKKCPQCGA 646 Query: 769 YFVLRDGAAGVFLAANTFPKSRETRA 794 V+R+G G F+A + +PK + T++ Sbjct: 647 QLVVRNGKRGEFIACSNYPKCKFTQS 672 >UniRef50_C0QYG0 DNA topoisomerase n=2 Tax=Brachyspira RepID=C0QYG0_BRAHW Length = 716 Score = 501 bits (1289), Expect = e-140, Method: Compositional matrix adjust. Identities = 291/758 (38%), Positives = 420/758 (55%), Gaps = 84/758 (11%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKAKTIN+YLGSDY+V SS+GH+ DLP S Sbjct: 28 LVIVESPAKAKTINRYLGSDYLVMSSMGHLIDLPRS------------------------ 63 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 R+ +D H +E Y + G+ K+++ELK+ A+KA+ + LA D DREGE+IAWH+ Sbjct: 64 -----RLAIDVDHGFEPEYITIRGRAKILNELKKEAKKAEEVLLAADDDREGESIAWHIG 118 Query: 125 EVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 I G ++ R+VF+EITK+A+++A ++P +++I +VNAQ+ARR +DR++GY +SPL Sbjct: 119 NKIRGVNSAVPIKRIVFHEITKDALKEAIDQPRDIDISKVNAQKARRVLDRLIGYNLSPL 178 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LW KI RGLSAGRVQ+VA+ ++ RE EI+ FVP E+W + E LA ++ Sbjct: 179 LWDKIKRGLSAGRVQNVALLIICNREDEIETFVPVEYWTFGVFLKHKNKEFLAELQKYKG 238 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 +KP K+ + + L+ Y+V E K P AP+ TS LQQAAS+ LG+ Sbjct: 239 EKPDLKT-KQDVEDIMEHLKDKTYTVASIEVKDRLRNPTAPYTTSKLQQAASSALGYSAS 297 Query: 303 KTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 KTM +AQ LYE G ITYMRTDS +S A + +I +G YLP P Sbjct: 298 KTMQVAQSLYEGVDIAGEATGLITYMRTDSVRISPVAQEQAKEFIEKEYGSNYLPPEPPT 357 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 Y+ K+N+Q+AHEAIRP+++ + +S+K+ ++ D KLY+LIW +FV+ QM PAK +T Sbjct: 358 YSVKKNAQDAHEAIRPTNIFLTPDSIKEYLKTDQYKLYKLIWERFVSSQMLPAKMKNTRA 417 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI--LPAVNKGDALTLVELTPAQHFT 471 + AGD + FDG+ KV+ + K D+++ +P ++K D VE P QHFT Sbjct: 418 IIVAGDCEFSLSSSKIEFDGFMKVL-TIDKEDKEKASKMPNLSKDDVCEFVENNPQQHFT 476 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 PP R+++ASLVK LE+ GIGRPSTYA I TI R YV+ + ++ ++G++V + + Sbjct: 477 TPPPRYTDASLVKILEESGIGRPSTYAPTIKTIISRHYVQRKGKQLVPTELGKLVNELIS 536 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 ENF EL+N +FTA ME+ LD++ + EW +L F+ F L A ++ M+ Sbjct: 537 ENFPELVNINFTADMESKLDKIEDDNIEWNNILKEFYPHFLDTLKTATENI--NNMKDFF 594 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 T C CG+KM R G F+ CSG+ CK T + Sbjct: 595 NEETDFVCEKCGKKMIKRLGRYGYFIACSGFP-----ECKNTKGI--------------- 634 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE- 710 + CPKCG + R+ + C N P CD +D P+ E Sbjct: 635 ------SFGVCPKCGGDITLKRSKRGREFYGCSNYPKCD----------FVSWDKPLQEP 678 Query: 711 CEKCGSEMHLK-MGRFGKYMACTNEECKNTRKILRNGE 747 C KCG M K + G + C E+C + +I + E Sbjct: 679 CPKCGGLMVEKNIKNKGLFKVCIKEDCGYSEEIKEDEE 716 >UniRef50_B9L0B0 DNA topoisomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0B0_THERP Length = 744 Score = 500 bits (1287), Expect = e-139, Method: Compositional matrix adjust. Identities = 309/767 (40%), Positives = 431/767 (56%), Gaps = 105/767 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ALVIVESPAKA+TI ++LG Y VK+S+GH+RDLP S Sbjct: 34 GQALVIVESPAKARTIARFLGPGYTVKASMGHVRDLPKS--------------------- 72 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++GVD N++ Y VL K VV EL++ ++A + LATD DREGEAIAW Sbjct: 73 --------KLGVDVAQNFQPTYTVLKEKLPVVKELQESVQRARELILATDPDREGEAIAW 124 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL E D R+VF+EIT+ AIR+A P +++ VNAQQARR +DR+VGY +SP Sbjct: 125 HLIEATRAHDKPVRRIVFHEITEEAIREALAHPRGIDMRLVNAQQARRVLDRLVGYEISP 184 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFW--EVDASTT-----TPSGEAL 234 LLW+K+ GLSAGRVQSVA+RLVV+REREI+AFVP+E+W EVD T P A Sbjct: 185 LLWRKVKSGLSAGRVQSVALRLVVDREREIQAFVPQEYWTIEVDLVPTGNGAQEPVPFAA 244 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 AL V + +KP P N+E +A LE ++Y V+ +++ +P PFITSTLQQ A Sbjct: 245 AL-VRVRGEKPDLP-NEEAARAVARELEASQYWVVSIKERQKQRRPAPPFITSTLQQEAG 302 Query: 295 TRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 +L F V TM +AQ+LYE G ITYMRTDST ++ A R I+ +G Sbjct: 303 RKLRFPVSLTMQLAQQLYEGVELGPEGSVGLITYMRTDSTQVAASAQQRAREVIAARWGA 362 Query: 346 KYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQLIWRQFVACQM 403 +LPE P YA K + +QEAHEAIRP+D ES++ Q +LY+LIW +F+A QM Sbjct: 363 DFLPERPPVYAKKAKGAQEAHEAIRPTDPARDPESVRPYLTPRQYQLYRLIWERFIASQM 422 Query: 404 TPAKYDSTTLTVGAG-------DFRLKARGRILRFDGWTKV-----MPALRKGDEDRILP 451 PA YD+ T+ + AG + L+A G ++RF G+ V + R LP Sbjct: 423 APAIYDTVTVEIAAGPTVGADAPYLLRATGSVVRFPGFLVVYREERDEDEVDELDQRPLP 482 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR 511 + G+ L L+ + P QHFT+PP R+SEA+LVK LE+ GIGRPSTYA I T++ R YV Sbjct: 483 PLATGEVLRLLAVRPEQHFTQPPPRYSEATLVKTLEELGIGRPSTYAPTIETLKQRRYVV 542 Query: 512 VENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 VE+R+ ++G +VTD L ++F ++++ FT+++E LD++A E +W V+ F+ F Sbjct: 543 VEDRKLVPTELGMLVTDLLVQHFPDVVDVGFTSRLEEELDEIAAGERDWVPVVREFYEPF 602 Query: 572 TQQLDKAEKDPEEGGM--RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 +Q+++AE+ E + +P+ V C CGR M I+ + G FL CSG+ Sbjct: 603 HRQVEEAEQTMERVRLADQPSGEV-----CELCGRPMVIKESRFGRFLSCSGFP-----E 652 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK-RKLHVCGNNPT 688 CK N P E + V RCP+CG K R + C P Sbjct: 653 CK---NKRPLLEKIGV---------------RCPQCGEGEIVVRRSRKGRTFYGCSRYPD 694 Query: 689 CD--GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN 733 CD +E GE C +CG + + + R + + C++ Sbjct: 695 CDFVSWERPTGE-----------RCPQCGGVLVVSVRRGQESVRCSS 730 >UniRef50_D1U7W1 DNA topoisomerase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7W1_9DELT Length = 821 Score = 499 bits (1285), Expect = e-139, Method: Compositional matrix adjust. Identities = 319/825 (38%), Positives = 443/825 (53%), Gaps = 108/825 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAK KTI+K+LG DY+V +SVGH+RDLPT Sbjct: 1 MPKDLIIVESPAKVKTISKFLGKDYMVDASVGHVRDLPT--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD + + YE++ GKE+VV LK A+KA +YLA D DREGEAIA Sbjct: 40 --------RDLGVDEENGFTPRYEIIQGKEEVVKRLKAAAKKAGTVYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ E++ ++ R+ FNEIT A+++A +LN + ++QQARR +DR+VGY +S Sbjct: 92 WHVAELLRPVNSNIRRIQFNEITARAVKEALENAQDLNQNLFDSQQARRILDRLVGYKIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWK + RG+SAGRVQSVA++L+VERE+E +AF +E+W + L++ Sbjct: 152 PILWKNVKRGISAGRVQSVALKLLVEREKERRAFKTDEYWPFKVLLEGGNPPPFWLELHK 211 Query: 241 QNDKPFRP-VNKEQTQAAV----SLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 + K +P VN TQA LE +++V ++K P P+ITSTLQQ A+ Sbjct: 212 LSGKAVKPGVNHISTQAEAEALQQTLEAGQFTVDSVQEKQRKRDPLPPYITSTLQQDANR 271 Query: 296 RLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 R+G+ K+TM +AQRLYE ITYMRTDS ++++A R I D FG Sbjct: 272 RMGYSAKRTMSVAQRLYEGVELGRHGTTALITYMRTDSVRIAKEAQEAARELIIDRFGAD 331 Query: 347 YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTP 405 Y P P + +K +Q+AHEAIRP DV + + +K + ++ KLY+LIW++FVA QM Sbjct: 332 YYPSKPRNFKTKGGAQDAHEAIRPVDVTITPDDVKSSLPSEQHKLYRLIWQRFVASQMAA 391 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI-LPAVNKGDALTLVEL 464 A + TT+ V A +A+G L F G+ M + G E LP + +G+ L L EL Sbjct: 392 ASFWDTTVLVSAPATEWRAKGERLLFPGFLAAMD--KSGTEAETELPKLVEGETLRLNEL 449 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 Q FT+PP R+SEASLVK LE+ GIGRPSTYA+IIST+ DR Y R E +RF ++G Sbjct: 450 KKEQKFTQPPPRYSEASLVKTLEELGIGRPSTYAAIISTLLDREYARQEEKRFVPTELGF 509 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 V+D+L E+F LM+ FTAQME+ LD VA + +W +L F DF L+KA + Sbjct: 510 TVSDQLSEHFHALMDVGFTAQMESLLDDVAAGKQDWAKLLKDFGHDFYPTLEKARTE--- 566 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV-PENEVL 643 M +Q T I C CG+ M I+ TG FLGC+G+ C+T N EN + Sbjct: 567 --MARSQQE-TDIVCENCGKPMSIKFGKTGEFLGCTGFPT-----CRTIKNFTRDENGAI 618 Query: 644 NVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE---------- 693 ++E E E + C KCG M I R+ G C GY Sbjct: 619 RIVERETPEETGV----ECEKCGKPM---AIKQSRRGEFLG----CTGYPDCKNIVNFQR 667 Query: 694 --------IEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG-KYMACTN-EECKNTRKIL 743 IE + ++ G C CG E+ LK R G +++AC+N +C Sbjct: 668 DENGAISVIESEKLQVVG------SCPDCGGELLLKKARTGSRFIACSNYPDCT------ 715 Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPK 788 A P VP P C R G +F + + +PK Sbjct: 716 ----YAAPFSTGVPCPVEGCAGELVEKSSRRGK--IFFSCSAYPK 754 >UniRef50_A8ZW15 DNA topoisomerase n=3 Tax=Desulfobacteraceae RepID=A8ZW15_DESOH Length = 758 Score = 496 bits (1277), Expect = e-138, Method: Compositional matrix adjust. Identities = 301/819 (36%), Positives = 430/819 (52%), Gaps = 139/819 (16%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K ++IVESP K KTI KY G+ Y V ++ GH+RDLP Sbjct: 1 MNKPVIIVESPTKVKTITKYTGNAYSVTATSGHLRDLPP--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + +G+D + + Y + GK+KV+ LK AD IYLA D DREGEAIA Sbjct: 40 --------HELGIDIDNGFAPDYVNIKGKQKVIKALKSAVGDADDIYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ +++ R+ RV+F+E+TK I++ +P ELN +R +AQQARR +DR+VGY +S Sbjct: 92 FHVADLLKKKGRRFHRVMFHELTKTGIQKGLTEPTELNRNRYDAQQARRILDRLVGYQIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLW+K+ GLSAGRVQSVAVR++ +REREI AF P+E+W + A+ + ++ Sbjct: 152 PLLWRKVRNGLSAGRVQSVAVRIICDREREIFAFDPQEYWSITAALEGANPPRFEAKLVK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + K N+ + V L + ++V + K P PF TS LQQ A +LGF Sbjct: 212 KGTKNITIGNQAEADRIVDELSRQAFTVDKIVQKTIKRNPQPPFTTSKLQQEAIRKLGFT 271 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 KKTM +AQ LYE G ITYMRTDST ++ +A + +I FG Y P+ Sbjct: 272 AKKTMAVAQELYEGIDLGPGEPVGLITYMRTDSTRIAPEAAHEALAHIRSVFGNDYAPDR 331 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 P +A+K Q+AHEAIRP+ ++ ES+K + D LY LIW++FVA QM+ A+ D Sbjct: 332 PRFFANKNKVQDAHEAIRPTGISYTPESVKRYLSKDQLTLYTLIWKRFVASQMSEAQIDQ 391 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVM---------PALRKGDEDRILPAVNKGDALTL 461 T+T+ AGD+ L G +RF G+ + P KGD+ LP +++ + L L Sbjct: 392 KTITIAAGDYLLSVSGSTVRFPGFMALYQPEEDKNGAPDKDKGDK---LPQLDEKEVLKL 448 Query: 462 VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521 +EL P QHFT PP RFSEASLVKELE+ GIGRPSTYA+I+STI+D+GYV + N+ F + Sbjct: 449 IELDPKQHFTTPPPRFSEASLVKELEENGIGRPSTYATILSTIRDKGYVDLINKAFRPTE 508 Query: 522 MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 +G IV D L ENF +++ +FTA MEN LD++ + + + +L+ F+ F+Q+++ A+ Sbjct: 509 LGFIVNDLLVENFPTILDIEFTANMENDLDRIESDQLQAVRLLERFYGPFSQRIEAAKDR 568 Query: 582 PEEGGMRPNQMVL--TSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV-- 637 MR + V T + CP CG+++ I+ G FL CSGY CK + N Sbjct: 569 -----MRSVKGVGMDTGLSCPECGKELKIKLGKNGPFLACSGYP-----DCKFSRNYART 618 Query: 638 ------PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDG 691 P L V EG + C KCG+ M Sbjct: 619 DKGTVEPVEPDLTVAEG-----------KSCEKCGSPM---------------------- 645 Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAP 750 +K GR+G ++AC+ +CK+T+ + AP Sbjct: 646 ---------------------------VVKQGRYGDFLACSAYPDCKSTQSLNSGANAAP 678 Query: 751 PKEDPVPLPELPCEKSDAYFVLRDGAAG-VFLAANTFPK 788 V PE C + V + G VF + FPK Sbjct: 679 IG---VKCPEPGC---NGDIVEKKSKRGKVFYGCSRFPK 711 Score = 53.9 bits (128), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 48/89 (53%), Gaps = 3/89 (3%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRN--GEVAPPKEDPVPLPELPCEK 765 + C +CG E+ +K+G+ G ++AC+ +CK +R R G V P + D CEK Sbjct: 581 LSCPECGKELKIKLGKNGPFLACSGYPDCKFSRNYARTDKGTVEPVEPDLTVAEGKSCEK 640 Query: 766 SDAYFVLRDGAAGVFLAANTFPKSRETRA 794 + V++ G G FLA + +P + T++ Sbjct: 641 CGSPMVVKQGRYGDFLACSAYPDCKSTQS 669 >UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8_PELCD Length = 841 Score = 496 bits (1276), Expect = e-138, Method: Compositional matrix adjust. Identities = 308/798 (38%), Positives = 433/798 (54%), Gaps = 107/798 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M ++LVIVESPAKAKTI K+LG Y V +S GH+R LP+ + Sbjct: 1 MAQSLVIVESPAKAKTIEKFLGPGYKVLASYGHVRALPSKQGS----------------- 43 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VD HN+ Y VLP +K + LK+ A+K+ + LATD DREGEAIA Sbjct: 44 ------------VDVEHNFSPLYHVLPESQKHIELLKKEAKKSRELILATDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYS----RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WHL E +G D+ S RV F+EITK AI++A +KPG + + V+AQQAR +D +VG Sbjct: 92 WHLLEALGIDENAKSPEVKRVTFHEITKGAIQEAISKPGHIARELVDAQQARSILDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 + +SP LWKKI GLSAGRVQSVA+RL+ ERE+EI+AF E+W ++ T G Sbjct: 152 FNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFEAREYWTIETRLATEQGSVFPA 211 Query: 237 QVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSK---PGAPFITSTLQQAA 293 ++ + + Q A+ L++ + E TSK P APF TSTLQQ A Sbjct: 212 RLYAVDGNSLGKFDINQEAQALELVKAIGSEAFQVEKLKKTSKKRNPAAPFTTSTLQQEA 271 Query: 294 STRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 S +LGF +KTM +AQ+LYE G ITYMRTDS LSQ A R I+ +G+ Sbjct: 272 SRKLGFSARKTMTVAQKLYEGIDVGNGLEGLITYMRTDSVALSQVATGEARELITRMYGE 331 Query: 346 KYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQM 403 Y + P + +K +N+QEAHEA+RP+ ++ + + +K + +D KLY+LIW++ VA QM Sbjct: 332 DYALDKPRVFKNKAKNAQEAHEAVRPTSLSNLPDQIKAHLSSDQFKLYRLIWQRTVASQM 391 Query: 404 TPAKYDSTTLTVGAGD-FRLKARGRILRFDGWTKVMPALRKGDEDR------ILPAVNKG 456 A+ ++TT+ + AG+ F +A G+++RF G+ K+ DED+ LP + + Sbjct: 392 ATAQLEATTVDIRAGERFVFRASGQVVRFPGFMKLYIEDTDKDEDQDRQEEGTLPPLEQE 451 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 L E+ P+QHFT+PP RF+EASLVK LE+ GIGRPSTYASII+T+ R YVR+E R Sbjct: 452 QPLDCQEVQPSQHFTQPPPRFTEASLVKTLEEHGIGRPSTYASIINTLTTRKYVRLEKRA 511 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 FY E +G +V D L +F + ++YDFTAQ+E LD ++ E EW+ VL F+ F +L Sbjct: 512 FYTEDVGMVVNDLLVNHFNKYVDYDFTAQLEEDLDAISRGEREWQPVLKDFWEPFISRLK 571 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 + E + + + T CP CG+ + I+ +G FL CSG+ Sbjct: 572 EKETQISKQDVTTEK---TDRICPECGKPLVIKLGRSGRFLACSGF-------------- 614 Query: 637 VPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR--KLHVCGNNPTCDGYEI 694 P+ L G++ E + + + C KCG M LI R K C P C + Sbjct: 615 -PDCRYTEPLAGQEREEPVM-SDQTCEKCGAPM---LIKQGRYGKFLACSAYPECKNIQ- 668 Query: 695 EEGEFRIKGYDGPIVE-------CEKCG-SEMHLKMGRFGKYMACTNE--ECKNTRKILR 744 P+V+ C +CG E+ K R+GK N +CK L Sbjct: 669 ------------PLVKPKALGITCPQCGEGELMEKKSRYGKIFYSCNRYPKCKYALWDL- 715 Query: 745 NGEVAPPKEDPVPLPELP 762 P E+P P + P Sbjct: 716 ------PIEEPCPKCKFP 727 Score = 50.1 bits (118), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 51/89 (57%), Gaps = 8/89 (8%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C +CG + +K+GR G+++AC+ +C+ T + +E+PV + + CEK A Sbjct: 591 CPECGKPLVIKLGRSGRFLACSGFPDCRYTEPL-----AGQEREEPV-MSDQTCEKCGAP 644 Query: 770 FVLRDGAAGVFLAANTFPKSRETRAPLVE 798 +++ G G FLA + +P+ + + PLV+ Sbjct: 645 MLIKQGRYGKFLACSAYPECKNIQ-PLVK 672 >UniRef50_B5EJ79 DNA topoisomerase n=61 Tax=Proteobacteria RepID=B5EJ79_ACIF5 Length = 851 Score = 494 bits (1271), Expect = e-138, Method: Compositional matrix adjust. Identities = 310/790 (39%), Positives = 432/790 (54%), Gaps = 102/790 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG D+ V +S GH+RDL +PK Sbjct: 1 MAHQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDL--------------------QPK 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VD H++ Y + E+ V + + AD ++LATD DREGEAI+ Sbjct: 41 EG---------AVDTEHDFAMRYTPIERNERHVDAIAKALRGADKLWLATDPDREGEAIS 91 Query: 121 WHL------REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 WHL R+++G D RVVF+EITK A+++A P E+ +D VNAQQARR +D + Sbjct: 92 WHLVELLRERQLLG--DKPTQRVVFHEITKKAVQEAIAHPREIAMDLVNAQQARRALDYL 149 Query: 175 VGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEAL 234 VG+ +SPLLW+K+ GLSAGRVQS A+RL+ ERE EI+AFV E+W + AS +G A Sbjct: 150 VGFNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTI-ASRLQHAGSAF 208 Query: 235 ALQVTHQNDKP---FRPVNKEQTQAAVSLLE----KARYSVLEREDKPTTSKPGAPFITS 287 ++TH +K F + +Q QA S +E + V E E K +P APF TS Sbjct: 209 TGRLTHWQNKKLEQFDIADGDQAQAIRSGMEDDLGRQALRVREVERKSRQRQPAAPFTTS 268 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYI 339 TLQQ AS +LGF +TM +AQ+LYE G I+YMRTD+ NL+++A+ +R +I Sbjct: 269 TLQQEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRTFI 328 Query: 340 SDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQ 397 +G +++PE+P +Y +K +N+QEAHEAIRP+D+ ESL+ +E D +LY L+W++ Sbjct: 329 DGYYGSEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPESLQGVLERDLWRLYDLVWKR 388 Query: 398 FVACQMTPAKYDSTTLTVGAG-DFRLKARGRILRFDGWTKVMPALRK-GDED---RILPA 452 +ACQM PA+ D + + AG + L+A G + F G+ V + GDED RILP Sbjct: 389 SIACQMAPARLDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDESNRILPP 448 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 ++ GD ++ + P QHFT+PP R+S+A+LVK LE GIGRPSTYASII T+Q+R YV V Sbjct: 449 LDVGDEPLVLGIDPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAV 508 Query: 513 ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 E RRF+ +G +V L +F ++Y FTA ME+ LD V+ E +W+ VL F+S F Sbjct: 509 EQRRFHPTDLGRVVGRFLINHFERYVDYGFTASMEDELDAVSRGEKQWQPVLSAFWSPFR 568 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSID--CPTCGRKMGIRTASTGVFLGCSGYALPPKERC 630 LD E+ + + +++ CP CG+ + +R G F+ CSGY Sbjct: 569 ALLD------EKANVSRAEATSEALEEACPQCGKPLFLRLGRHGRFVACSGY-------- 614 Query: 631 KTTINLVPENEVLNVLEG--EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPT 688 PE ++G E AE R CP CG + Y + C P Sbjct: 615 -------PECNYTRPVDGPREPAEP----VGRDCPDCGKPL-VYKTGRYGRFISCSGYPE 662 Query: 689 CDGYEIEEGEFRIKGYDGPIVECEKCG-SEMHLKMGRFGKYMACTNEECKNTRKILRNGE 747 C E + V C +CG E+ K R+GK N K T + Sbjct: 663 CKHIEP------LTQPKSSGVTCPQCGEGELVEKRSRYGKVFYSCNTYPKCTYAVW---- 712 Query: 748 VAPPKEDPVP 757 PP P P Sbjct: 713 -GPPVARPCP 721 >UniRef50_A8SJ74 DNA topoisomerase n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SJ74_9FIRM Length = 703 Score = 493 bits (1270), Expect = e-137, Method: Compositional matrix adjust. Identities = 282/751 (37%), Positives = 418/751 (55%), Gaps = 82/751 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 + K LVIVESP KAKT++K LGS+Y V +SVGHIRDLP S Sbjct: 7 LYKNLVIVESPTKAKTVSKMLGSNYKVVASVGHIRDLPKS-------------------- 46 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +MG+D +N+E Y + GK + ELK+L + +++IYLATD DREGEAI+ Sbjct: 47 ---------KMGIDIENNFEPEYINVRGKASKIKELKELYKNSENIYLATDPDREGEAIS 97 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ ++G D +R+ F+EITK +I+++ +++++ VN+QQARR +DR+VGY +S Sbjct: 98 WHIAYLLGLDINDNNRIEFHEITKKSIKESIKNSRKIDMNLVNSQQARRVLDRLVGYKLS 157 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKKI GLSAGRVQS ++++ ER+ EI FVPEEFW+++ + E +L Sbjct: 158 PILWKKIKSGLSAGRVQSATLKIICERQEEIDNFVPEEFWKIEGIHNVQNIEFKSLYYGE 217 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTS---KPGAPFITSTLQQAASTRL 297 +K + + A+ ++EK ED KP PF TSTLQQ A +L Sbjct: 218 YENKKIVKKEIKNEKEALKVVEKTDKDNFIVEDVKKVKKERKPQPPFTTSTLQQEAGRKL 277 Query: 298 GFGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 GF TM +AQ+LYE G I+YMRTDST +S + V YI++N+GK Y Sbjct: 278 GFSSSMTMSIAQQLYEGINVGKEGSVGLISYMRTDSTRISSEIVAEAIEYITENYGKNYA 337 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 + K+NSQ+AHE +RPS + E +K + ++ KLY+LIW + VA QM Sbjct: 338 SKGNEYNLKKKNSQDAHEGVRPSSIFRSPEKIKSYLTSNQYKLYKLIWERTVASQMKAES 397 Query: 408 YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 Y+ST + + + + K GR FDG++K+ + DE LP + D + ++ + Sbjct: 398 YESTQIVLNSNNCIYKLNGRYTLFDGFSKIYTSSDIKDEP--LPKLEVKDVINAEKIEKS 455 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFTKP A F+EASLVK+LE+ GIGRPSTYASII+++ R Y+ +EN++ +G+ V Sbjct: 456 QHFTKPVANFTEASLVKKLEENGIGRPSTYASIINSLTSRFYILIENKKIIPTDLGKNVN 515 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 L NF ++N FT +ME LD++A ++ +WK V+ F++ F L ++E D E+ + Sbjct: 516 KFLVSNFETIINEKFTMEMEEKLDEIAENKKDWKKVISDFYAVFETFLKRSEGDSEDYKI 575 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 + VL CP CG+ + I+ G F+GCSG+ P+ N ++ Sbjct: 576 KDE--VLDE-KCPQCGKNLVIKKTKFGRFIGCSGF---------------PD---CNYIK 614 Query: 648 GEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGP 707 E +T +CPKCG + + ++ + C N P CD Y I +D P Sbjct: 615 KEVKDTGV-----KCPKCGGRIIEKISKKRKVFYGCENYPECD-YAI---------WDKP 659 Query: 708 IVE--CEKCGSEMHLKMGRFGKYMACTNEEC 736 I + CEKCG + RF + C++E C Sbjct: 660 IADKKCEKCGKFLVEVKNRFKHALKCSDENC 690 >UniRef50_Q67PC7 DNA topoisomerase n=3 Tax=Bacteria RepID=Q67PC7_SYMTH Length = 735 Score = 492 bits (1266), Expect = e-137, Method: Compositional matrix adjust. Identities = 302/792 (38%), Positives = 431/792 (54%), Gaps = 127/792 (16%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+L+IVESPAKAKTI K+LG Y VK+S+GH+RDLP S Sbjct: 1 MPKSLIIVESPAKAKTIEKFLGRKYAVKASMGHVRDLPKS-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++GV +++E Y + GK ++ EL++ A KAD +YLATD DREGEAI+ Sbjct: 41 ---------QLGVSVENDFEPKYITIRGKGDILKELRESARKADRVYLATDPDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +V+ R+ F+EITK+AI++A +P ++++RV AQQARR +DR+VGY +S Sbjct: 92 WHLAQVLKLPLDEPLRIEFHEITKDAIQRAIKQPRPIDLNRVEAQQARRVLDRLVGYKLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ--- 237 PLLW+K+ RGLSAGRVQSVAVRL+V+REREI+AF PEE+W +DA +T ++ + + Sbjct: 152 PLLWRKVRRGLSAGRVQSVAVRLIVDREREIQAFQPEEYWTLDARLSTAFAQSFSARYWG 211 Query: 238 ----------------VTHQ---------------NDKPFRPVNKEQTQAAVSLLEKARY 266 V HQ P P + A L+ + R Sbjct: 212 MGEQKADLKTQDQVRAVVHQVAGDRLPAGNAAVSGEGTPGDPFTEVLDLAGEGLVLQVR- 270 Query: 267 SVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYI 317 SV RE K P PF TS+LQQ AS +LGF V++TM +AQ+LYE G + Sbjct: 271 SVKRREKK---RNPAYPFTTSSLQQEASRKLGFSVRRTMAVAQQLYEGLPLGEEGHTGLV 327 Query: 318 TYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMA 377 TY+RTDST ++ +A +I +GK Y+PE + + Q AHEAIRP+DV Sbjct: 328 TYIRTDSTRIADEAARAAAEFIERQYGKDYVPERRREPDRRAGEQGAHEAIRPTDVTRTP 387 Query: 378 ESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTK 436 ES+K + D +LY+LIW +F+A QM PA D+ T+ + AG+ +A G+ +RF G+ K Sbjct: 388 ESVKPYLTPDQYRLYRLIWERFLASQMAPAVLDTVTVELVAGEHVFRASGQSIRFPGFMK 447 Query: 437 VMPALRKGDEDR-----ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGI 491 V D R +LP + +G +TL L QHFT+PP R+SEA LVK LE+RGI Sbjct: 448 VYIEGEDDDGQREEGDDLLPELAEGQQVTLQTLEARQHFTQPPPRYSEAMLVKALEERGI 507 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 GRPSTYA II TIQ RGYV ++RFY ++G +VTD L+E F ++++ +FTA +E LD Sbjct: 508 GRPSTYAPIIGTIQTRGYVEKRDKRFYPTELGVLVTDILKEYFPDIIDVEFTAHLEGKLD 567 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 +V W+ ++ F+ F + L +AE+ + GG V + + C CGR M ++ Sbjct: 568 EVEEGRVNWRELIRRFYGPFEETLKQAEE--KVGGFELEDEV-SDVPCEKCGRLMVVKHG 624 Query: 612 STGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDS 671 G FL C G+ CK+T ++ E V CP CGT Sbjct: 625 RFGKFLACPGFP-----ECKSTKPILEETGVT------------------CPACGTGR-- 659 Query: 672 YLIDPK-----RKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL--KMGR 724 +++ K R+ + C N P C+ E+ R+ C +CG+ + ++ Sbjct: 660 -IVERKSKKGGRRFYGCTNYPDCNFVSWEKPVNRL---------CPECGAPYLVEKRIKE 709 Query: 725 FGKYMACTNEEC 736 G C +C Sbjct: 710 LGLSHVCKQPDC 721 >UniRef50_B2KBN6 DNA topoisomerase n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KBN6_ELUMP Length = 765 Score = 486 bits (1250), Expect = e-135, Method: Compositional matrix adjust. Identities = 298/781 (38%), Positives = 434/781 (55%), Gaps = 97/781 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK LVIVESP K KTI+K LG+DYVVKSS GH+RDLP+ Sbjct: 17 GKNLVIVESPTKQKTISKILGADYVVKSSFGHVRDLPS---------------------- 54 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +GVD + ++ Y + +K+VSEL++LA+ ++++YLATD DREGEAIAW Sbjct: 55 -------KEIGVDEKNGFKPKYVPVEKAKKMVSELEKLAKGSEYVYLATDPDREGEAIAW 107 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL E++ + R+ F+EIT A++ +F+ +N D V+AQQARR +DR+VGY +SP Sbjct: 108 HLVELLKIPVEKIRRIFFHEITPAAVKASFDHARNINKDLVDAQQARRVLDRLVGYKLSP 167 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFW----EVDASTTTPSGEALALQ 237 LLWKKI GLSAGRVQSVAVRL+ ER +EI+ F EE++ E++ TP A L+ Sbjct: 168 LLWKKITGGLSAGRVQSVAVRLLAERAKEIENFREEEYYSLTSELEKQGETPKFNARMLK 227 Query: 238 VTHQNDKPFRPVN--------------KEQTQAAV-SLLEKARYSVLEREDKPTTSKPGA 282 +N + + K + A V SLL + +V + E K K Sbjct: 228 WRGKNTEIITTYHLFAEDYKVKTTVFKKPEDLAPVNSLLRQGPLTVSKIEKKEVKQKAKP 287 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNM 334 PFITS+LQQ A ++GF +KTMM AQ LYE G ITYMRTDS N+S+D + Sbjct: 288 PFITSSLQQEAYNKIGFPSQKTMMTAQSLYEGVEIAGEVVGLITYMRTDSFNVSKDLQSQ 347 Query: 335 VRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQ 392 + +I+ +G ++P +PN + SK + +QEAHE+I P+DV S+KD + AD KLY+ Sbjct: 348 TKKFIAGKYGDDFVPPTPNFFKSKVKGAQEAHESIHPTDVYKTPASIKDYLSADQYKLYE 407 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAG---DFRLKARGRILRFDGWTKVMPALRKGDE--- 446 LIW +F+A QM A +++ ++ + AG + L+A GR ++F G+ V +E Sbjct: 408 LIWLRFIASQMADAVFNTVSVDITAGKAEECVLRATGRTVKFPGFLSVYKEDDSEEEDEG 467 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506 +LP + +GD L L+++ H T PP ++EASL+K LEK GIGRPSTYA I TI D Sbjct: 468 SALLPNLTEGDDLNLIDIVTKSHKTAPPPNYNEASLIKTLEKHGIGRPSTYAPTIKTILD 527 Query: 507 RGYV--RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 R Y+ + + + +G VTD+L++ F+++M+ +TA +E LD +A + +W V+ Sbjct: 528 RKYIIRQPKTNKLIVTDLGVTVTDQLKDFFKDIMDLSYTAGIEEKLDDIAEGDNDWVKVI 587 Query: 565 DHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYAL 624 F+ F + L A+KD + +P+ CP CG M IR + G +L CS Y Sbjct: 588 GDFYEGFKKDLATADKDMQRAAPKPSDE-----KCPLCGSPMVIRRSRFGEYLACSTYP- 641 Query: 625 PPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR--KLHV 682 CK INL E L E+ +C KCG+ M +I R K Sbjct: 642 ----ECKGKINLTSSGEKLAPEVTEE----------KCEKCGSPM---VIRSGRRGKFMA 684 Query: 683 CGNNPTC-DGYEIEEGEFRIKGYDGPI---VECEKCGSEMHLKMGRFGKYMACTN-EECK 737 C P C + + I+ ++ GPI ++CEKCG M L+ + G+++ C+ +CK Sbjct: 685 CSAFPKCKNTFSIDASGNKVAS-SGPIETKIKCEKCGKPMLLRASKRGEFLGCSGYPKCK 743 Query: 738 N 738 Sbjct: 744 T 744 Score = 60.1 bits (144), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 32/84 (38%), Positives = 46/84 (54%), Gaps = 6/84 (7%) Query: 710 ECEKCGSEMHLKMGRFGKYMAC-TNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA 768 +C CGS M ++ RFG+Y+AC T ECK + +GE P+ + E CEK + Sbjct: 616 KCPLCGSPMVIRRSRFGEYLACSTYPECKGKINLTSSGEKLAPE-----VTEEKCEKCGS 670 Query: 769 YFVLRDGAAGVFLAANTFPKSRET 792 V+R G G F+A + FPK + T Sbjct: 671 PMVIRSGRRGKFMACSAFPKCKNT 694 Score = 57.8 bits (138), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/153 (32%), Positives = 73/153 (47%), Gaps = 20/153 (13%) Query: 661 RCPKCGTAMDSYLIDPKR--KLHVCGNNPTCDGY--EIEEGEFRIKGYDGPIV---ECEK 713 +CP CG+ M +I R + C P C G GE P V +CEK Sbjct: 616 KCPLCGSPM---VIRRSRFGEYLACSTYPECKGKINLTSSGEKL-----APEVTEEKCEK 667 Query: 714 CGSEMHLKMGRFGKYMACTN-EECKNTRKILRNG-EVAPPKEDPVPLPELPCEKSDAYFV 771 CGS M ++ GR GK+MAC+ +CKNT I +G +VA P+ ++ CEK + Sbjct: 668 CGSPMVIRSGRRGKFMACSAFPKCKNTFSIDASGNKVA--SSGPIET-KIKCEKCGKPML 724 Query: 772 LRDGAAGVFLAANTFPKSRETRAPLVEELYRFR 804 LR G FL + +PK + + EE+ + + Sbjct: 725 LRASKRGEFLGCSGYPKCKTIVSVSPEEIAKIK 757 >UniRef50_C1ABE5 DNA topoisomerase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1ABE5_GEMAT Length = 816 Score = 485 bits (1249), Expect = e-135, Method: Compositional matrix adjust. Identities = 306/798 (38%), Positives = 436/798 (54%), Gaps = 111/798 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G +LVIVESPAKAKTI KYLG Y VK++VGH+RDLP Sbjct: 49 GTSLVIVESPAKAKTIGKYLGRGYTVKATVGHVRDLP----------------------- 85 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++G+D H + Y + GKE ++++LK++A+ A I++ATD DREGEAI W Sbjct: 86 ------AKKLGIDIDHGFAPEYVTIEGKEDILTDLKKVAKGAREIFIATDPDREGEAIGW 139 Query: 122 HLREVIG-----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 H+ + A RV+F+EITK+A+ ++ KP +++ +V AQQARR +DR+VG Sbjct: 140 HVEQYFTQPKRHAVSAPIRRVMFHEITKDAVHKSMAKPMDIDNKKVEAQQARRVLDRLVG 199 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 Y SP+LWK + +GLSAGRVQ+VA+RL+VEREREI+AF P E+W + A G+ Sbjct: 200 YKASPVLWKTVKKGLSAGRVQTVALRLIVEREREIRAFTPVEYWSIAADLQ--KGQQPFT 257 Query: 237 QVTHQND--KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 HQ D KP E + L + + V E + + P APF TSTLQQ A+ Sbjct: 258 AKLHQLDGKKPEIGNGTEAERIIADLAGRKEFVVTEVKRRERRKNPAAPFTTSTLQQEAA 317 Query: 295 TRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 +LGFG K+TM +AQ LYE G ITYMRTDST +S+DA N R + FG Sbjct: 318 KKLGFGSKRTMRLAQDLYEGIDVGIDGATGLITYMRTDSTRVSEDAANSARESLRAQFGD 377 Query: 346 KYLPESPNQYAS-KENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQM 403 +L +P Y S K N+Q+AHE +RP+D + E + K + AD KLYQLIW++F+A QM Sbjct: 378 DFLAPAPQLYPSGKANAQDAHEGVRPTDPSRRPEQVQKFLTADQFKLYQLIWQRFMASQM 437 Query: 404 TPAKYDSTT----LTVGAGD----FRLKARGRILRFDGWTKVMPALR-KGD-----EDRI 449 PA +D+TT + + D + +A G +++F G+ + R +GD +++ Sbjct: 438 APAVFDTTTVDFNIPIKVADAERNYLFRATGSVVKFQGFLALYREAREEGDAKALEDEQA 497 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 LP + + + + +TP QHFT+PP RFSEASLVKELE+ GIGRPSTYASIIS + +R Y Sbjct: 498 LPVLEVDERVPVKAITPTQHFTEPPPRFSEASLVKELERAGIGRPSTYASIISVLVERRY 557 Query: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 V +E RRF+ +GE V + + F ++ N FTAQME LD++A E +W L F++ Sbjct: 558 VSLEQRRFFPTSLGETVEKVMVKKFPDVFNVGFTAQMEEELDKIAEGEIDWVRALGDFWT 617 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 F + L+ + D G + L + CP CG K+ + G F+ C + PK Sbjct: 618 PFQRTLNDNDLDALIGEAY-DLSALETERCPDCGGKLVAKGGFFGPFVACENH---PKA- 672 Query: 630 CKTTINLVPEN---EVLNVLEGEDAETNALRAKR--------RCPKC-GT-AMDSYLIDP 676 CK T + E E+ N + E +R R + PKC GT +M + + P Sbjct: 673 CKYTRPIKGEKKPAELTNYMCQECGAPMVIRHGRSGDFLGCSKFPKCRGTRSMPTGVKCP 732 Query: 677 K--------------RKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE-CEKCG-----S 716 K + + C N P CD F + +D P+ E C +CG + Sbjct: 733 KDGGEIAERRSKKRGKAFYGCENYPNCD--------FVV--WDKPVAETCPECGYVGAEA 782 Query: 717 EMHLKMGRFGKYMACTNE 734 + + G F K + C+NE Sbjct: 783 KSNKTRGSFRKCLKCSNE 800 Score = 55.8 bits (133), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 33/86 (38%), Positives = 45/86 (52%), Gaps = 9/86 (10%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN--EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA 768 C CG ++ K G FG ++AC N + CK TR I GE + P L C++ A Sbjct: 646 CPDCGGKLVAKGGFFGPFVACENHPKACKYTRPI--KGE-----KKPAELTNYMCQECGA 698 Query: 769 YFVLRDGAAGVFLAANTFPKSRETRA 794 V+R G +G FL + FPK R TR+ Sbjct: 699 PMVIRHGRSGDFLGCSKFPKCRGTRS 724 >UniRef50_Q1RIM1 DNA topoisomerase 1 n=35 Tax=Rickettsiales RepID=TOP1_RICBR Length = 800 Score = 485 bits (1248), Expect = e-135, Method: Compositional matrix adjust. Identities = 302/779 (38%), Positives = 435/779 (55%), Gaps = 97/779 (12%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKAKTINKYLG ++ V +S GHIRDLP+ ++ Sbjct: 3 LVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPS-----------------------KK 39 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 G+++ P N+ Y++ K V + + A+KA+ +YLATD DREGE+I+WH+ Sbjct: 40 GSVI------PDENFSMKYDISEKAGKYVDAIIKDAKKAESVYLATDPDREGESISWHIA 93 Query: 125 EVIG-----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 EVI D + RV FNEITK AI A P +L+ + VNAQQARR +D +VG+ + Sbjct: 94 EVIKEKNKVKSDDFFKRVAFNEITKKAITHAIENPRKLDNNLVNAQQARRALDYLVGFTL 153 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SPLLW+K+ SAGRVQSVA+RL+ ERE EI+ F EE+W++ + E ++T Sbjct: 154 SPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMLNSNNELFTAKLT 213 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKAR---YSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 H ND+ + + A L EK + + V + E K +P PFITS+LQQ A+ + Sbjct: 214 HINDQKLEKFSITNDKEAKDLTEKLKSQNFHVDKIEKKQQKRQPQPPFITSSLQQEAARK 273 Query: 297 LGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LGF KKTM +AQ+LYE G ITYMRTD LS DAV+ +R I+ ++G KYL Sbjct: 274 LGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAVDEIRKLINKDYGDKYL 333 Query: 349 PESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPA 406 P SP Y SK +N+QEAHEAIRP+++N + LK+ +E D KLY+LIW++ +ACQM Sbjct: 334 PSSPRIYKSKVKNAQEAHEAIRPTNINYIPNDLKEKLEKDYYKLYELIWKRTIACQMENV 393 Query: 407 KYD--STTLTVGAGDFRLKARGRILRFDGWTKVMPAL---RKGDEDRILPAVNKGDALTL 461 D + TL ++ +A G + FDG+ KV +E+++LP + + + L Sbjct: 394 IMDLVNATLASENKEYLARANGSTIAFDGFYKVYRESIDDEAEEENKMLPPLKEQEHLKT 453 Query: 462 VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521 E+ P QHFT+PP R+SEASLVK+LE+ GIGRPSTYA+I+S +QDR YV +E +RF E+ Sbjct: 454 KEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYATILSVLQDRKYVTLEKKRFIPEE 513 Query: 522 MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 +G +VT L F++ + YDFTA +EN LD++A + EWK+ L +F++ F ++ K Sbjct: 514 LGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKSALGNFWNGFNHNIESVNKQ 573 Query: 582 PEEGGMRPNQMVL---------TSIDCPTCGR-KMGIRTASTGVFLGCSGYALPPKERCK 631 + Q L S CP+C ++ ++ G FL CS Y P+ + Sbjct: 574 NITEIISYVQQALDYHIFGENKDSKVCPSCKTGELSLKLGKFGAFLACSNY---PECNFR 630 Query: 632 TTI--------------NLVPENEVLNVLEGEDAETNALRAKRR----CPKCGTAMDSYL 673 +I ++V EN+VL G+D E + K+ + G +DS Sbjct: 631 KSIVSGNDNNEADGEAKDIVNENKVL----GKDKEGIEIYLKKGPYGPYIQYGEQVDSK- 685 Query: 674 IDPKRKLHVCG---NNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYM 729 I PKR G N+ T D ++ I ++ G E+ + G+FG Y+ Sbjct: 686 IKPKRSPLPAGLNQNDITLD------MALKLLSLPLKIGNHKESGEEVLVGYGKFGPYI 738 >UniRef50_D1C7I9 DNA topoisomerase n=8 Tax=Bacteria RepID=D1C7I9_SPHTD Length = 769 Score = 484 bits (1247), Expect = e-135, Method: Compositional matrix adjust. Identities = 300/775 (38%), Positives = 425/775 (54%), Gaps = 119/775 (15%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKA+ I + LG Y VK+S+GH+RDLP S Sbjct: 62 LVIVESPAKARNIGRILGRGYTVKASMGHVRDLPKS------------------------ 97 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 ++GV+ ++ Y + K KVV EL+ ++A I LATD DREGEAIAWHL Sbjct: 98 -----KLGVETDRDFAPVYLIPRDKSKVVKELRADVKEAREILLATDPDREGEAIAWHLV 152 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 E D R+VF+EIT AIR+A P +++ V AQQARR +DR+VGY +SPLLW Sbjct: 153 EATDPGDKPVRRIVFHEITPEAIREALRNPRGIDMRLVEAQQARRILDRLVGYEISPLLW 212 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDK 244 +K+ RGLSAGRVQSVA+RLVVEREREI+ FVP+E+W +DA A V + K Sbjct: 213 RKVKRGLSAGRVQSVALRLVVEREREIQNFVPQEYWTLDAEL------AKREAVNGRKPK 266 Query: 245 PF----------RPVNKEQ--TQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 PF +P K++ T A V L+ A + V++ E K T +P PF TSTLQQ Sbjct: 267 PFVASLSRVNGQKPDLKDEASTMAIVRALDGAEFQVVKVEVKETQRRPAPPFTTSTLQQE 326 Query: 293 ASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNF 343 AS +L V++TM +AQ LYE G ITYMRTDSTN++ A R I++ + Sbjct: 327 ASRKLNMPVRRTMQIAQELYEGIDLGDAGTVGLITYMRTDSTNVAASAQARAREVIAERY 386 Query: 344 GKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQ----KLYQLIWRQF 398 G ++LP+ P Y K + +QEAHEAIRP+D ES+K A KLY+LIW++F Sbjct: 387 GPEFLPDRPPVYTRKAKGAQEAHEAIRPTDPARDPESIKAFLGGASSPRYKLYRLIWQRF 446 Query: 399 VACQMTPAKYDSTTLTVGAG------DFRLKARGRILRFDGWTKVMPALRKG-DEDRI-- 449 +A Q A +DST + + AG +R +A G +++F G+ + R+G D+D + Sbjct: 447 IASQTRNAVFDSTAVDIDAGPPGGPKPYRFRATGSVIKFPGFLAIY---REGRDDDTVDE 503 Query: 450 -----LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTI 504 LP + +G+ L LV L P QHFT+PP RF+EA+LVK LE+ GIGRPSTYA I+T+ Sbjct: 504 IDREALPPLTEGEVLDLVRLLPEQHFTQPPPRFTEATLVKALEELGIGRPSTYAPTIATL 563 Query: 505 QDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 Q R YV VE RR Y ++G +V D L ++F ++++ +FT+++E+ LDQ+A+ E W ++ Sbjct: 564 QARNYVTVEQRRLYPTELGTVVNDLLVQHFPDIVDVNFTSKLEDELDQIASGEQSWVPMV 623 Query: 565 DHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYAL 624 F+ F + +++AEK E G ++ + C CGR M I+ G FL CSG+ Sbjct: 624 RAFYGPFHETVERAEK--EIGRVKVADEPTDEV-CEKCGRPMVIKLGRYGRFLACSGFP- 679 Query: 625 PPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA-MDSYLIDPKRKLHVC 683 C+ N P + + V CP+CG + R + C Sbjct: 680 ----ECR---NARPLLQKIGVT---------------CPQCGEGDIVQRRTKKGRVFYGC 717 Query: 684 GNNPTCDGYEIEEGEFRIKGYDGPIVE-CEKCGSEMHLKMGRFGKYMACTNEECK 737 P C+ ++ P E C +CG + + G + C+ + C+ Sbjct: 718 SRYPDCN----------FSSWEKPTGEPCPQCGGVL---VETRGGTVRCSTQGCQ 759 Score = 51.2 bits (121), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 24/55 (43%), Positives = 36/55 (65%), Gaps = 2/55 (3%) Query: 700 RIKGYDGPIVE-CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPK 752 R+K D P E CEKCG M +K+GR+G+++AC+ EC+N R +L+ V P+ Sbjct: 643 RVKVADEPTDEVCEKCGRPMVIKLGRYGRFLACSGFPECRNARPLLQKIGVTCPQ 697 >UniRef50_Q7NGH1 DNA topoisomerase n=1 Tax=Gloeobacter violaceus RepID=Q7NGH1_GLOVI Length = 765 Score = 483 bits (1244), Expect = e-134, Method: Compositional matrix adjust. Identities = 308/790 (38%), Positives = 432/790 (54%), Gaps = 97/790 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+LVIVESPAKAKTI+K LG ++VVK+S GHIRDLP Sbjct: 1 MSKSLVIVESPAKAKTISKILGKNFVVKASAGHIRDLPQ--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 MGV+ +++E Y ++P KE+VV ELK A AD +YLA D DREGEAIA Sbjct: 40 --------KEMGVNVKNDFEPKYVIIPKKEEVVEELKGAARNADRVYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ R R+ F+EITK AI+ A P +++I+RV+AQQARR +DR+VGY +S Sbjct: 92 WHLAQILDIPGDRLQRIEFHEITKQAIQNAVAHPRDIDINRVDAQQARRILDRLVGYKLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA---STTTPSGEALALQ 237 PLLWKK+ RGLSAGRVQSVAVRL+ +RE+EI+AFV EE+W V + + Sbjct: 152 PLLWKKVQRGLSAGRVQSVAVRLLCDREKEIQAFVSEEYWTVHGRFRQSAQVEATPFSAD 211 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + K N+ +A V +L A V + + +P PFITSTLQ+ ++ L Sbjct: 212 LVRWSGKKPDLGNETAARAVVEVLTGAASRVDSVKTRERQKEPQPPFITSTLQREGASAL 271 Query: 298 GFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 G VK+TM +AQ+LYE G ITYMRTDST ++++A R +I +GK Y Sbjct: 272 GLTVKRTMAIAQQLYEGIDLGEEGPVGLITYMRTDSTRVAEEAQEAAREFILAAYGKSYY 331 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMTPAK 407 P QY +K+ +Q+AHE +RP+D+N +++ K + D KLY+LIW++F A QMT A Sbjct: 332 PSRRRQYGAKKGAQDAHECVRPTDINRPPDAIKKSLTPDQFKLYRLIWQRFTASQMTAAT 391 Query: 408 YDSTTLTVGA--------GDFRLKARGRILRFDGWTKVMPALRK----GDEDR--ILPAV 453 ++ T+ + A FR+ I FDG+T+V R+ GDE+ P + Sbjct: 392 LETRTVEIAATPTAGRPDALFRVSVTRTI--FDGYTRVYEEAREEAATGDEEAAGAAPVL 449 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513 +G+ALTL+ + P QHFT+PPARFSEA+LVK LE++GIGRPSTYA I TIQ+RGYV + Sbjct: 450 EEGEALTLLTVDPKQHFTQPPARFSEATLVKALEEQGIGRPSTYAPTIGTIQERGYVNKD 509 Query: 514 NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ 573 R +G V D+L ++F +++ +FTA ME LD+V W +L F+ F + Sbjct: 510 GRTLIPTDLGMKVNDQLVQHFPNIVDTEFTANMEAQLDEVEKGSQRWTQLLADFYGPFVE 569 Query: 574 QLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTT 633 L A+++ + +++T C +CGR + R G FLGCSGY C T Sbjct: 570 TLKAADEEMK------RVVIVTDHLCESCGRPLLNRYGRFGNFLGCSGYP-----ECDFT 618 Query: 634 INLVPENE-VLNVLEGEDAETNALRAK------------RRCPKCGTAM--DSYLIDPK- 677 L +N+ V E N +CP CG + + + PK Sbjct: 619 HQLTRDNKPVPKDRPAEGISCNQCGHAPMLITYGRYGEYLKCPACGKSQPKSTGITCPKC 678 Query: 678 -------RKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYM- 729 R+ + N CD Y + + D P C +CGS + K + G M Sbjct: 679 SKGQIVERRSKMGKNFYGCDQYPDCDFVLWSRPIDKP--ACPECGSILLYKPRKRGDDMV 736 Query: 730 ACTNEECKNT 739 AC+ CK T Sbjct: 737 ACS--ACKFT 744 >UniRef50_B3EPW7 DNA topoisomerase n=12 Tax=Chlorobiaceae RepID=B3EPW7_CHLPB Length = 804 Score = 483 bits (1242), Expect = e-134, Method: Compositional matrix adjust. Identities = 311/824 (37%), Positives = 431/824 (52%), Gaps = 135/824 (16%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L++VESP+KAKTINKYLGSDY+V +SVGHI+DLP KK Sbjct: 12 GKTLIVVESPSKAKTINKYLGSDYLVFASVGHIKDLP---------------------KK 50 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + +G+D +N+E YEV+ GKEKVV +LK+LA +A+ I +ATD DREGEAIAW Sbjct: 51 E--------IGLDFDNNYEPRYEVISGKEKVVRQLKKLAGQANDILIATDPDREGEAIAW 102 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ + RV+FNEITK AI +A N P +++ V +QQ R+ +D++VGY +SP Sbjct: 103 HIANEVDAAQKPVHRVLFNEITKKAILEAINDPLQIDYRLVRSQQTRQGLDKIVGYKISP 162 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LW + RGLSAGRVQSV++RL+ ERE EI F P+E+W + A TT SGE + ++ Sbjct: 163 FLWNVVMRGLSAGRVQSVSLRLICEREAEIDKFEPKEYWTIFADFTTGSGETFSTKLVRI 222 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + N+ + S + Y V E + KP PF TS LQQAAS +LGFG Sbjct: 223 DSNKAEITNQSDAEKTASDILSRIYGVAEITPRVQQRKPPFPFTTSLLQQAASNQLGFGS 282 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KKTM +AQ+LYE G ITYMRTDST +S +AV +I+ +FG ++ Sbjct: 283 KKTMRVAQQLYEGIDLGPEGATGLITYMRTDSTRVSGEAVEQAERFITQHFGPEFT--GG 340 Query: 353 NQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 Q A K + +Q+AHEAIRP+ V E++K + +D KLY+LIW++F+A +M PAK + Sbjct: 341 GQAAKKGKKTQDAHEAIRPTGVPRTPETMKPFLSSDQYKLYELIWKRFLASRMAPAKIEQ 400 Query: 411 TTLTVGAGD--FRLKARGRILRFDGWTKVMPALRKGD--------ED-------RILPAV 453 T + V + F +A G + F G+ KV ++ D ED ++ + Sbjct: 401 TRVDVADHEKQFIFRASGSNVLFPGFLKVYNEQKELDYEARKSTREDEEKEQIVKLPRNL 460 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513 + LTL L Q FT+PPARF+EASLVKEL+ GIGRPSTYA I ST+QDR YV +E Sbjct: 461 TVNEKLTLDTLDKKQSFTRPPARFTEASLVKELDNYGIGRPSTYAGIFSTLQDRRYVELE 520 Query: 514 NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ 573 ++ ++G+ V+ L NF +L N FTA MEN LD++A + E++ VLD F+ Sbjct: 521 KKKIIPTELGKDVSMILVANFPDLFNVTFTAHMENELDKIAAGDDEYEQVLDSFYKPLES 580 Query: 574 QLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTT 633 L + DP Sbjct: 581 ALSVRKNDP--------------------------------------------------- 589 Query: 634 INLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE 693 L+P+N DAET C KCG K C + P C + Sbjct: 590 --LLPQNT--------DAET--------CDKCGKGKMIIKWTASGKFLGCSSYPACKNIK 631 Query: 694 -IEEGEFRIKGYDGPIVECEKC-GSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAP 750 + R K ++C C M L+ GRFG ++ACT +C K+ + ++ P Sbjct: 632 PLASSRVRPKETG---IKCHGCENGRMVLRNGRFGPFLACTGYPDCNTLLKLDKQRKIEP 688 Query: 751 PKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 PK P+ +L C K A LR G G++L + FPK R +A Sbjct: 689 PKTPPLET-DLACPKCGAPLYLRTGKRGLWLGCSKFPKCRGRQA 731 >UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_AMMDK Length = 686 Score = 479 bits (1232), Expect = e-133, Method: Compositional matrix adjust. Identities = 288/752 (38%), Positives = 415/752 (55%), Gaps = 84/752 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+IVESPAKA+T++K+LGS ++VK+S+GH+RDLP S Sbjct: 2 KHLIIVESPAKARTLSKFLGSQFLVKASMGHVRDLPKS---------------------- 39 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +GVD + + Y + GK KV+ ELK KAD + +A+D DREGEAIAWH Sbjct: 40 -------ELGVDLENGFTPKYVTIRGKGKVIQELKSYVAKADTVLMASDPDREGEAIAWH 92 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L ++G RV F+EITKNA+ + P ++++RVNAQQARR +DR+VGY +SPL Sbjct: 93 LCHLLGIPPETPCRVEFHEITKNAVLNSLKSPRPIDLNRVNAQQARRVLDRLVGYGLSPL 152 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LW+K+ RGLSAGRVQSVA+RLVVERE EI+AF PEE+W++ TP E + ++ Sbjct: 153 LWRKVKRGLSAGRVQSVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLARLARFK 212 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K F E+ + S A + V + + P PF TS + Q A+ RLG ++ Sbjct: 213 GKKFTCRTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQEANRRLGMRLE 272 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE-SP 352 +TM +AQ+LYE G ITY+RTDST +S++A +I +++G +++ + P Sbjct: 273 RTMAVAQQLYEGVDLGPEGPVGLITYIRTDSTRVSEEAKERAWAFIKEHYGAEFVGDVPP 332 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 + +K ++AHEAIRP+DV E +K + D KLY+LIW +F+A M PAKY T Sbjct: 333 KERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLIWERFLAAHMAPAKYFLT 392 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + GD+ A GR L F G+ ++ + +E + LP + +G+ LT E P QHFT Sbjct: 393 RAEIEVGDYTFYATGRQLLFPGFLRLWRPEEEEEEGK-LPPLREGEVLTFQEFVPQQHFT 451 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 PP R++E +LVK LE++G+GRPSTYA I TI RGYV ++ + +G V + L+ Sbjct: 452 TPPPRYTEGTLVKALEEKGVGRPSTYAPTIETILKRGYVVRVDKYLHPTPLGRTVVELLK 511 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 E+F +++ FTA ME LD V +A+W +L F+ F+Q L +A+ E+ + P+ Sbjct: 512 EHFPGIVDVGFTAAMEEKLDLVEEGQADWVDILREFYQSFSQDLVRADAAIEKVSL-PD- 569 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEV-LNVLEGED 650 T I CP CG M +T G FL CSGY PE ++ + V G Sbjct: 570 -TFTDISCPRCGCPMVKKTGRYGEFLACSGY---------------PECQMRMPVGTGV- 612 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710 +CP+CG + R + C P C+ F + + P+ E Sbjct: 613 ----------KCPRCGGELVKRRSKKGRYFYGCNRYPECN--------FVV--WSEPVPE 652 Query: 711 -CEKCGSEMHLKMGRF-GKYMACTNEECKNTR 740 C +CGS M ++ GR K + CTNE C R Sbjct: 653 PCPECGSLM-VRRGRGKKKRVICTNESCGYQR 683 >UniRef50_B9L7D9 DNA topoisomerase n=1 Tax=Nautilia profundicola AmH RepID=B9L7D9_NAUPA Length = 728 Score = 478 bits (1231), Expect = e-133, Method: Compositional matrix adjust. Identities = 296/752 (39%), Positives = 421/752 (55%), Gaps = 91/752 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKA+TI +LG +Y V +S GHIRDLP + K D Sbjct: 1 MAKNLIIVESPAKARTIKNFLGKEYEVVASKGHIRDLPKTSFGIKIEED----------- 49 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + Y V + + ELK+ A+KA+ IY+ATD DREGEAI Sbjct: 50 -----------------KFIPQYRVTADHQPIAKELKEKAKKAETIYIATDEDREGEAIG 92 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ VIG R+VF+EITK AI++A P ++++RVNAQQARR +DR+VGY +S Sbjct: 93 YHIAHVIGKKPEELPRIVFHEITKTAIKKALENPRTIDLNRVNAQQARRLLDRIVGYKLS 152 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLL KKI +GLSAGRVQS A++LVV+REREIKAF P+E+W ++ G + Sbjct: 153 PLLNKKIQKGLSAGRVQSAALKLVVDREREIKAFKPQEYWSIEGIFKKIEGSLIKYN-GK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + DK F +K++ Q V L+ Y+V E E K TT K APF+TSTLQQ AS+ LGF Sbjct: 212 KLDK-FDIKSKDEAQKIVEELKPLEYTVREIETKTTTVKSPAPFMTSTLQQVASSELGFS 270 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 +KTM +AQ+LYE G ITYMRTDS N++++A +I N G++Y Sbjct: 271 PRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQQAALEFIKQNIGEEYA--QA 328 Query: 353 NQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 YA+K +N+QEAHEAIRP DV + + LK+ ++ D KLY LI+ +F+A QM AK+++ Sbjct: 329 KTYATKNQNAQEAHEAIRPVDVRLTPDDLKNYLKPDELKLYALIFNRFLASQMKDAKFET 388 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 + + K GR L FDG+ KV K + +LP KG+ L ++ QHF Sbjct: 389 QNIYIANDKGEFKISGRKLIFDGFYKVY---GKPSANTLLPEFEKGEKLKPEDVKATQHF 445 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 TKPP R++EASL+K+LE GIGRPSTYA I+ +Q+R YV V++++ + ++ V + L Sbjct: 446 TKPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEVKDKKLHPTEIAFSVIETL 505 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 E++F ++++ +FTA ME LD+VA + +W+ VL F++ F + ++K K+ P+ Sbjct: 506 EKHFPDIVDANFTANMEEMLDEVAEAKKDWQEVLKDFYNPFMELVNKGYKE------IPS 559 Query: 591 QMVLTSID--CPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 Q + ID CP CG + IR G F+ CS Y +CK T L Sbjct: 560 QKIAKPIDETCPLCGSPLVIRKGRFGEFIACSSYP-----KCKYTRPLEESK-------- 606 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRK---LHVCGNNPTCDGYEIEEGEFRIKGYD 705 E+ +T+ +C KCG M + K K C N P C K + Sbjct: 607 EEKKTDV-----KCDKCGADM----VVKKGKSGEFLACSNYPKCKN---------TKPLN 648 Query: 706 GP----IVECEKCGSEMHLKMGRFGKYMACTN 733 P V+C +CG ++ + R G++ C N Sbjct: 649 APEVLDDVKCPECGGDIVKRKSRRGEFYGCAN 680 Score = 53.1 bits (126), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 32/89 (35%), Positives = 52/89 (58%), Gaps = 10/89 (11%) Query: 707 PIVE-CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCE 764 PI E C CGS + ++ GRFG+++AC++ +CK TR + + E K D + C+ Sbjct: 565 PIDETCPLCGSPLVIRKGRFGEFIACSSYPKCKYTRPLEESKEEK--KTD------VKCD 616 Query: 765 KSDAYFVLRDGAAGVFLAANTFPKSRETR 793 K A V++ G +G FLA + +PK + T+ Sbjct: 617 KCGADMVVKKGKSGEFLACSNYPKCKNTK 645 >UniRef50_D1B6D6 DNA topoisomerase I n=3 Tax=Synergistaceae RepID=D1B6D6_THEAS Length = 708 Score = 478 bits (1231), Expect = e-133, Method: Compositional matrix adjust. Identities = 270/704 (38%), Positives = 391/704 (55%), Gaps = 74/704 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 + LV+VESP KAK+++K LG Y V++S+GH+ DLP Sbjct: 43 ETLVVVESPTKAKSLSKMLGPGYAVEASLGHVMDLPKV---------------------- 80 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 R+GVD + +E Y + GK V+ LK+LA A + LA+D DREGEAIAWH Sbjct: 81 -------RLGVDVENGFEPEYIQVRGKGPVIKRLKELARGASRVLLASDPDREGEAIAWH 133 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L ++G RV +EIT + I A + +++++V AQQARR +DR+VGY +SPL Sbjct: 134 LATLLGVPLDSPCRVRIHEITPSGISAALQEVEGIDMNKVYAQQARRVLDRLVGYRLSPL 193 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LW K+ RGLSAGRVQSVA+RLV ERE EI +FVPEE+W V+ G + L++ + Sbjct: 194 LWAKVQRGLSAGRVQSVALRLVCEREDEIDSFVPEEYWLVEVQAEAEGGRSYLLKLDKEA 253 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 KP R ++ + +L+ + V + +P PF TSTLQQ AS RLG+G + Sbjct: 254 GKPVRLKDQADARRVEALVRSSPLQVSSFRSRDGLRRPMPPFKTSTLQQEASRRLGYGPR 313 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 +TM +AQ L+E G ITYMRTDS +S +A++ +RG+I+ FG YLPE PN Sbjct: 314 RTMRIAQSLFEGVEIPGRGPVGLITYMRTDSLRISDEAISAMRGHIASRFGPMYLPERPN 373 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 +A K SQ+AHEAIRP+DV + +++++ + ++ +LY LIWR+ +A QM A+ + T Sbjct: 374 HFAQKGRSQDAHEAIRPTDVTLEPDAIREYLSSEQYRLYDLIWRRALASQMADARVRTNT 433 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 L G+ K G + F GW V P G +D +PA ++G+ L +++ Q FT+ Sbjct: 434 LEARCGELTFKCSGVEVTFQGWGAVWPL---GVKDTEVPAASEGEDLRPLQVRLEQKFTQ 490 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY-VRVENRRFYAEKMGEIVTDRLE 531 PP R++EA L+K LE++GIGRPSTYA+I+ T+ DRGY VR ++++ K+G +V L Sbjct: 491 PPGRYTEAGLIKALEEKGIGRPSTYATIVETLSDRGYVVRDDDKKLSPTKLGRVVNAFLV 550 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 +F +++ DFTA+ME+ LD+V + E +W+ + F+ F +L + + + P Sbjct: 551 THFPDVVQVDFTARMEDQLDRVESGEIQWREPIGDFYGPFESRLQEVAASAQRMTVPPE- 609 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 L DCP CGR + IR G F+GCSGY + K T VP Sbjct: 610 --LAGEDCPQCGRPLLIRRGRYGEFIGCSGYPECDFTKRKETSTGVP------------- 654 Query: 652 ETNALRAKRRCPKCGTAM-----DSYLIDPKRKLHVCGNNPTCD 690 CPKCG S R + C P CD Sbjct: 655 ----------CPKCGQGTVVARKASKGKGKGRTFYGCSRYPECD 688 >UniRef50_C6WSV7 DNA topoisomerase n=4 Tax=Proteobacteria RepID=C6WSV7_METML Length = 864 Score = 478 bits (1231), Expect = e-133, Method: Compositional matrix adjust. Identities = 281/656 (42%), Positives = 397/656 (60%), Gaps = 61/656 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDL-PTSGSAAKKSADSTSTKTAKKPKKDE 63 L+IVESP+KAKT+ KYLGSD+ V +S GH+RDL P +G+ Sbjct: 4 LLIVESPSKAKTLKKYLGSDFEVLASYGHVRDLIPKNGA--------------------- 42 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 VD + + Y+++ K V + + + AD IYLATD DREGEAI+WH+ Sbjct: 43 ---------VDTENQFAMKYDIIERNSKHVDAIAKAVKNADSIYLATDPDREGEAISWHI 93 Query: 124 REV----IGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 E+ + RVVF+EITK A+ A +P ++++ VNAQQARR +D +VG+ + Sbjct: 94 AEILKSKKLLKNKLMKRVVFHEITKGAVEHAIAEPRDISMPMVNAQQARRALDYLVGFNL 153 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV--DASTTTPSGEALALQ 237 SPLLWKKI RGLSAGRVQS A+RL+VERE EI+AF +E+W + DA +A +Q Sbjct: 154 SPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWSIHLDALKHQHGFKAKLVQ 213 Query: 238 VTHQNDKPFRPVNKEQTQAAVS--LLEKARYSVLEREDKPTTSK-PGAPFITSTLQQAAS 294 + +Q + F +N +Q V LL A + + R +K S+ P APF TSTLQQ A Sbjct: 214 LNNQKVEQFTVINHDQQSDIVGKLLLASAGKTTVSRVEKKQRSRSPAAPFTTSTLQQEAV 273 Query: 295 TRLGFGVKKTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 +LGF + M +AQ+LYE G ITYMRTDS +L+ +AV +R Y+ NF + Sbjct: 274 RKLGFTTSRAMRVAQQLYEGVDVGGGTVGLITYMRTDSFSLATEAVMQIRDYVKKNFDTE 333 Query: 347 YLPESPNQYASKENS-QEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQLIWRQFVACQMT 404 YLP+SP Y +K S QEAHEAIRP+D++ S++ D Q KLY++IW++ +ACQM Sbjct: 334 YLPKSPVMYKTKSKSAQEAHEAIRPTDISRTPTSVRQYLNDEQFKLYEMIWKRALACQMA 393 Query: 405 PAKYD--STTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI---LPAVNKGDAL 459 PAK+D S L+VG+ +A G+ L F G+ V +E+ LP + G+ L Sbjct: 394 PAKFDAVSVDLSVGSDANLFRATGQTLVFPGFIAVYMEGSDDEEEEAESKLPNLETGEIL 453 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 T+ ++ QHFT+PP R+SEASLVK LE+ GIGRPSTYASIIST+QDR YV ++ +RF Sbjct: 454 TVEKIYGEQHFTEPPPRYSEASLVKVLEEYGIGRPSTYASIISTLQDREYVLLDKKRFTP 513 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 +G +V L E+F + ++YDFTA +EN+LD VA E +W ++D F+ DF QQ+ + Sbjct: 514 TDVGRVVNKFLTEHFTKYVDYDFTANLENALDSVAEGERDWVPLMDEFWQDFNQQIHN-K 572 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 D E G N+++ + CP CG+ + + + G F+GC+GY PK K +I+ Sbjct: 573 ADVERPG---NELIDEA--CPKCGKPLQKQLSRFGSFIGCTGYNDTPKCDYKRSID 623 >UniRef50_A0LDV2 DNA topoisomerase I n=7 Tax=Proteobacteria RepID=A0LDV2_MAGSM Length = 783 Score = 476 bits (1226), Expect = e-132, Method: Compositional matrix adjust. Identities = 324/823 (39%), Positives = 441/823 (53%), Gaps = 127/823 (15%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 A+VIVESPAKAKTINK+LG Y V ++ GHIRDLP+ + Sbjct: 3 AVVIVESPAKAKTINKFLGRGYKVVATYGHIRDLPSKNGS-------------------- 42 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 VD H + Y V K V EL + + A+ + LATD DREGEAI+WH+ Sbjct: 43 ---------VDTEHGFAMKYSVPKDSTKRVDELAKAVKGAEQVLLATDPDREGEAISWHV 93 Query: 124 REVIGG----DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 EV+ ++ + RVVF+EITK AI+ A ++++D VNAQQARR +D +VG+ + Sbjct: 94 YEVLNEKKLLENVQVKRVVFHEITKTAIQDAVAHARDVDMDMVNAQQARRALDYLVGFNL 153 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT-------PSGE 232 SPLLW+K+ RGLSAGRVQSVA+RLV ERE EI+AF E+W + A P Sbjct: 154 SPLLWRKVRRGLSAGRVQSVALRLVCEREAEIQAFEAREYWSITALAAQAAQSAPRPFEA 213 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 LA+ + K F ++ + + +EK V E E K + P PFITSTLQQ Sbjct: 214 RLAVADGEKLSK-FSIGDEAYAKRLIKAVEKRPLYVSEIEKKQSKRNPAPPFITSTLQQE 272 Query: 293 ASTRLGFGVKKTMMMAQRLYEA-------------GYITYMRTDSTNLSQDAVNMVRGYI 339 AS +LGF KKTM +AQRLYE G I+YMRTDS NL+ +A+ +R I Sbjct: 273 ASRKLGFSAKKTMTVAQRLYEGMEVPTADGGKETVGLISYMRTDSVNLANEAIESIRKQI 332 Query: 340 SDNFGKKYLPESPNQY-ASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQ 397 +GK+YLP+SP +Y +S +N+QEAHEAIRP+DV E L++ +E D +LY+LIW++ Sbjct: 333 EIRYGKEYLPKSPRKYKSSAKNAQEAHEAIRPTDVIRTPEMLREILEKDQFRLYELIWKR 392 Query: 398 FVACQMTPAKYD--STTLTVGAGD----FRLKARGRILRFDGWTKVMPALRKGDE----D 447 VACQM AK D + L+V + D +R +A G + F G+ KV + DE D Sbjct: 393 TVACQMAQAKIDKVAANLSVDSQDPNAAYRFRATGSSVAFAGFMKVY--MEGKDEVSAQD 450 Query: 448 R---------ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYA 498 R ILP + G L L QHFT+PP R++EA+LVK LE GIGRPSTYA Sbjct: 451 REDDDDDNESILPPLEVGQQLEQKSLDARQHFTEPPPRYTEATLVKVLESYGIGRPSTYA 510 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 +ST+QDRGYV+++ R+FY E +G +V L ++F ++Y+FTA +E+ LD V+ E Sbjct: 511 PTMSTLQDRGYVKLDARKFYPEDVGMVVNSYLTKHFSTYVDYNFTANLEDQLDAVSRGEK 570 Query: 559 EWKAVLDHFFSDFTQQLD-KAEKDPEEGGMRPNQMVLTSID--CPTCGRKMGIRTASTGV 615 W +++ F+ F QQ+ K E +E ++ ID CP CG + I+ G Sbjct: 571 SWVPLMEDFWQPFIQQITLKDETTSKE------EVTTEQIDEPCPKCGAPLSIKLGRFGK 624 Query: 616 FLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLID 675 F C+GY CK T L E EV + E E + C KCG M LI Sbjct: 625 FKACTGYP-----ECKHTEPLNKEEEV-SRPEPELTDIP-------CDKCGKPM---LIK 668 Query: 676 PKR--KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL-KMGRFGK-YMAC 731 R K + C P C + + R G V C CG L K R GK + +C Sbjct: 669 EGRYGKYYGCSGAPECKNNQ-PLNKPRDTG-----VACPSCGQGTFLEKKSRRGKIFYSC 722 Query: 732 TN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLR 773 +N +CK ++P+ E+PC K A FV + Sbjct: 723 SNYPKCKQAL-----------WDEPL---EIPCPKCQAPFVTK 751 Score = 58.5 bits (140), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 27/81 (33%), Positives = 49/81 (60%), Gaps = 4/81 (4%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C KCG+ + +K+GRFGK+ ACT ECK+T + + EV+ P+ + L ++PC+K Sbjct: 608 CPKCGAPLSIKLGRFGKFKACTGYPECKHTEPLNKEEEVSRPEPE---LTDIPCDKCGKP 664 Query: 770 FVLRDGAAGVFLAANTFPKSR 790 ++++G G + + P+ + Sbjct: 665 MLIKEGRYGKYYGCSGAPECK 685 >UniRef50_A9FRC6 DNA topoisomerase I n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FRC6_SORC5 Length = 864 Score = 476 bits (1225), Expect = e-132, Method: Compositional matrix adjust. Identities = 322/857 (37%), Positives = 444/857 (51%), Gaps = 146/857 (17%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI KYLG+ Y V +S GH++DLP +A Sbjct: 1 MAKTLVIVESPAKAKTIKKYLGNGYEVFASKGHVKDLPKKQNA----------------- 43 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VD +++ YEV+ GKEKV+ ELK A+KAD + LATD DREGEAIA Sbjct: 44 ------------VDVQNDFAETYEVIEGKEKVLEELKSAAKKADEVLLATDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ E I + +RV F+EITK + + P +L+ + +AQ+ARR +DR+VGY VS Sbjct: 92 FHISEEIKNPKLKVARVEFHEITKKGVDHGVHNPRKLDENLYDAQRARRVLDRIVGYDVS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD---ASTTTPSGEALALQ 237 L+W K+A GLSAGRVQSVA+RL+V+RERE++AFVPEE+W + + + P + Sbjct: 152 ALVWSKLAFGLSAGRVQSVALRLIVDREREVEAFVPEEYWNIAVGLGAASPPQRAPFVAK 211 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + K N E + LE ARY V + + P AP+ TS LQQ A+ L Sbjct: 212 LASADGKKLEVTNGEVAGKVRADLETARYRVAKVVRREQKRNPPAPYTTSKLQQDATNYL 271 Query: 298 GFGVKKTMMMAQRLYEA----------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 FG K+TM +AQ LYE G ITYMRTDST +S DAV VRG ++ +GK++ Sbjct: 272 HFGAKRTMQIAQALYEGIDLKRDGGPVGLITYMRTDSTRVSDDAVAEVRGVVAKRYGKEF 331 Query: 348 LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQLIWRQFVACQMTPA 406 +PE PN + SK+N+Q+AHEAIRP+ V + +S+K D Q KLY+LIW +FVA QMTPA Sbjct: 332 VPERPNVFKSKKNAQDAHEAIRPTSVEIHPDSIKKHLKDEQYKLYKLIWNRFVASQMTPA 391 Query: 407 KYDSTTL------TVGAGDFR---LKARGRILRFDGWTKVMPALR--------------- 442 YD TT+ T+ A +R +A GRIL+F GW +V + Sbjct: 392 VYDRTTVEIDVAPTLAAPAYRSYLARATGRILKFAGWLQVTEGQQEFAGEEESAGAAADG 451 Query: 443 -----------------------KGDEDRILPAVNKGDALTLVE--LTPAQHFTKPPARF 477 + D + +LP + +G+AL++ + Q FT+PP R+ Sbjct: 452 GAAAPAPEATAAEAERAAPGPSAEEDSEALLPDMKEGEALSVSPPGVITDQKFTQPPPRY 511 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYV-RVENRRFYAEKMGEIVTDRLEENFRE 536 +E SLV+ELEKRGIGRPSTYA IIS +Q R YV + + F +G+ V D L + + Sbjct: 512 NEGSLVRELEKRGIGRPSTYAEIISKVQQRAYVEKRDGGAFQPTLLGKFVVDGLVRSNLD 571 Query: 537 LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTS 596 +M+ +FTAQME LD V + + +L F+ F +QLDK++K +P + T Sbjct: 572 IMDPNFTAQMEEELDAVGAGSLKREQLLKSFYKKFREQLDKSKK---LAPWKP-EAEKTD 627 Query: 597 IDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNAL 656 I C CG M + G FL C Y +CK T +L V E + + Sbjct: 628 IVCDECGSMMLKKWGKNGWFLSCERYP-----KCKATRDLSDARGTAAVRETDIS----- 677 Query: 657 RAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI-VECEKCG 715 C KCG M +I R G+ +C GY + + P+ V C CG Sbjct: 678 -----CDKCGKPM---IIKTGR----FGDFLSCTGYPACKNTRPV-----PLGVACPSCG 720 Query: 716 SEM-----HLKMGRFGKYMACT--NEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA 768 ++ K GR + C+ N E K K+ + PVP +PC + A Sbjct: 721 GDLIEIRPRKKGGR--TFYGCSNWNAEQKCEFKLWQK---------PVP---VPCPQCGA 766 Query: 769 YFVLRDGAAGVFLAANT 785 FV R L T Sbjct: 767 KFVTRTAGKKAMLVCAT 783 Score = 43.1 bits (100), Expect = 0.045, Method: Compositional matrix adjust. Identities = 24/86 (27%), Positives = 43/86 (50%), Gaps = 6/86 (6%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD 767 + C++CGS M K G+ G +++C +CK TR + A +E ++ C+K Sbjct: 628 IVCDECGSMMLKKWGKNGWFLSCERYPKCKATRDLSDARGTAAVRET-----DISCDKCG 682 Query: 768 AYFVLRDGAAGVFLAANTFPKSRETR 793 +++ G G FL+ +P + TR Sbjct: 683 KPMIIKTGRFGDFLSCTGYPACKNTR 708 >UniRef50_C6HWV0 DNA topoisomerase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HWV0_9BACT Length = 865 Score = 473 bits (1217), Expect = e-131, Method: Compositional matrix adjust. Identities = 313/844 (37%), Positives = 438/844 (51%), Gaps = 128/844 (15%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G L++VESP KA+T+ + LG DY VK+SVGH++DLP S Sbjct: 47 GGTLIVVESPTKARTLTRILGPDYRVKASVGHLKDLPAS--------------------- 85 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 R+GVD ++E +EV GK+KV+ E++Q A A IYLA+D DREGEAIA+ Sbjct: 86 --------RIGVDVDRDYELEFEVSEGKKKVLDEIRQAARGAREIYLASDPDREGEAIAY 137 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ + RV+ +E+T I QA PGE+++ +V+AQ+ARR +DR+VGY +SP Sbjct: 138 HIASELSSLKKPIRRVLVHELTPRGIAQALEHPGEIDLHKVDAQKARRALDRIVGYSLSP 197 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV-DASTTTPSG---EALALQ 237 LLW+++ RGLSAGRVQSVAVRLV +RE EI AFVP E+W + T SG +A + Sbjct: 198 LLWERVRRGLSAGRVQSVAVRLVCDRENEINAFVPVEYWTILQTFHPTESGRETDAFEAK 257 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + ++++ QA + L + + +P P TS LQQ + R Sbjct: 258 LDRIAGEKAEIGSQQEAQAVLERLSGENFRIGSVSADEKKRQPSPPLTTSRLQQEGARRF 317 Query: 298 GFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 F KKTM +AQ+LYE G ITYMRTDS L+ +A M R YI N+ + L Sbjct: 318 RFPAKKTMQVAQKLYEGVEIPGQGLTGLITYMRTDSVRLAPEAQEMARDYIRRNY-PQGL 376 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 P Y +K+ Q+AHEAIRP+DVN ESL ++ D ++YQLIW+ FV QM PA+ Sbjct: 377 PSKSPSYRNKKGIQDAHEAIRPTDVNRTPESLASVLDRDLLRVYQLIWQSFVESQMLPAR 436 Query: 408 YDSTTLTV-GAGDFRLKARGRILRFDGWTKVMPALRKG---------------DEDRILP 451 Y TT+ V G +A GR + G+ V A KG +E+ LP Sbjct: 437 YLQTTVIVEGDQADSFRATGRRMLDPGFLAVRGARGKGAARSAKNEEEEDGTDEEEAELP 496 Query: 452 AVNKGDALTLVELTP---AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508 +++G+ ++V L P +QHFT+PP R++EASL++ELE++GIGRPSTYA+I++TI DR Sbjct: 497 LLHEGE--SVVALGPPDASQHFTQPPPRYNEASLIRELEEKGIGRPSTYATIMTTILDRE 554 Query: 509 YVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 YV RFY ++G+ V L ++F +L+N FTA+ME LD V + ++ +D F+ Sbjct: 555 YVEKRENRFYPTELGQTVNRLLVDSFPDLLNVAFTARMEEELDAVEEGDKVYREAVDDFY 614 Query: 569 SDFTQQLDKAEKDPEEGGMR--PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPP 626 F+ +L +A+ GGM + T I CP CG M + G +L C Y Sbjct: 615 RPFSAELGRAKG----GGMTNLKAKSEPTDIPCPVCGTLMVKKWGRHGAYLACGNYPA-- 668 Query: 627 KERCKTTINLV-----PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR--K 679 CKTT N+V P EVL GE +T CG M ++ R Sbjct: 669 ---CKTTRNIVQTESGPAPEVLPEAPGEVCQT-----------CGKPM---IVRKGRFGT 711 Query: 680 LHVCGNNPTCDGYEIEEGEFRIKGYDGPIV-------ECEKCGSEMHLKMGRFGKYMACT 732 C + P C + KG P V C CG M +K GRFG +++C Sbjct: 712 FLACSDYPACKTTR----PWPPKGQPSPPVPLPADLPPCPACGGAMVVKSGRFGSFLSCA 767 Query: 733 N-EECKNTRKILRNGEVAPPKEDPVPLPE-LPCEK--SDAYFVLRDGAAGVFLAANTFPK 788 N CK TR PLP + C + D V R G GVF + +P+ Sbjct: 768 NYPACKTTR----------------PLPTGIRCTRPGCDGEIVPRRGKRGVFYGCSRYPE 811 Query: 789 SRET 792 T Sbjct: 812 CDRT 815 Score = 71.2 bits (173), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 46/144 (31%), Positives = 64/144 (44%), Gaps = 22/144 (15%) Query: 662 CPKCGTAM-------DSYLIDPKRKLHVCGNNPTC----DGYEIEEGEFRIKGYDGPIVE 710 CP CGT M +YL CGN P C + + E G + P Sbjct: 643 CPVCGTLMVKKWGRHGAYL--------ACGNYPACKTTRNIVQTESGPAPEVLPEAPGEV 694 Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C+ CG M ++ GRFG ++AC++ CK TR G+ +PP P LP PC Sbjct: 695 CQTCGKPMIVRKGRFGTFLACSDYPACKTTRPWPPKGQPSPPVPLPADLP--PCPACGGA 752 Query: 770 FVLRDGAAGVFLAANTFPKSRETR 793 V++ G G FL+ +P + TR Sbjct: 753 MVVKSGRFGSFLSCANYPACKTTR 776 Score = 56.6 bits (135), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 34/89 (38%), Positives = 45/89 (50%), Gaps = 8/89 (8%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP---CE 764 + C CG+ M K GR G Y+AC N CK TR I++ E P P LPE P C+ Sbjct: 641 IPCPVCGTLMVKKWGRHGAYLACGNYPACKTTRNIVQT-ESGP---APEVLPEAPGEVCQ 696 Query: 765 KSDAYFVLRDGAAGVFLAANTFPKSRETR 793 ++R G G FLA + +P + TR Sbjct: 697 TCGKPMIVRKGRFGTFLACSDYPACKTTR 725 >UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LM02_9FIRM Length = 799 Score = 473 bits (1217), Expect = e-131, Method: Compositional matrix adjust. Identities = 293/783 (37%), Positives = 427/783 (54%), Gaps = 101/783 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L+IVESPAKAKTI + LGSDY V +S+GH+RDLP Sbjct: 31 GKHLIIVESPAKAKTIERILGSDYKVLASMGHLRDLPQ---------------------- 68 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +GVD ++++ Y + V+ L++ A K+ I LATD DREGEAI+W Sbjct: 69 -------RTLGVDVANDFKPEYVSSAERADVIENLQKEANKSKDILLATDPDREGEAISW 121 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL +++ D +R+ F+EIT AI++A P ++++RV+AQQARR +DR+VGY +SP Sbjct: 122 HLSKLLDVDPRSNARIAFHEITPPAIKEAVLHPEPIDLNRVDAQQARRVLDRLVGYKLSP 181 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LWK+I RGLSAGRVQSVA RL+ ERE EI+AF P E+W V+ T E+ ++T Sbjct: 182 WLWKQIYRGLSAGRVQSVATRLICEREEEIRAFKPVEYWTVEGIYRTEEKESFKAKLTQV 241 Query: 242 NDKPFRPVNKEQTQAAVS--LLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 + K + N E+ V L + A + + + K +KP P+ TST+QQ A RL F Sbjct: 242 DGKEAKINNAEEADRVVRGILKQPAEITSVTKTKKQRKAKP--PYTTSTMQQDAVNRLNF 299 Query: 300 GVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 G KKTM +AQ LYE G ITYMRTDST +S + + VR YI +GK YLP Sbjct: 300 GSKKTMALAQMLYEGIEIPGHGHVGLITYMRTDSTRISDEMIKQVRPYIERVYGKDYLPP 359 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 PN YA ++SQ+AHEAIRP+++ + L + D +LY LIW +F+A QM P Sbjct: 360 KPNVYARGKDSQDAHEAIRPTNLQFAPDMLAAVLSRDQLRLYTLIWNRFLASQMAPQISQ 419 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR----ILPAVNKGDALTLVELT 465 +T + +G + L+A G + FDG+T V+ +++ +D ILPA++KG + + Sbjct: 420 ATNAVLQSGIYTLRATGTQILFDGFT-VLRTVKEKKQDNEELPILPALHKGHTVLNTKAE 478 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 QHFT PP R++EASL+K LE++GIGRPSTYA I+ TIQ R YV E ++F +G Sbjct: 479 GEQHFTAPPPRYTEASLIKTLEEKGIGRPSTYAPILDTIQRRKYVEKEGKQFVPTDIGFK 538 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 VTD L++ F +++ DFTAQ+E LD++A+ +A +K V+ F+ F ++L A + E Sbjct: 539 VTDLLKKYFAGIVSVDFTAQLETWLDKIADGKATYKKVMSGFWDVFEKELQNA--NLEAA 596 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 + ++ + C CG M ++ + G +L C + CK N+ P + Sbjct: 597 KAKEENQEVSDVICEKCGAHMIVKMSRYGKYLACPNFP-----SCK---NIKPYHTGEEK 648 Query: 646 LEGEDAETNALRAKR-----------RCPKCG----TAMDSYLIDPK------------- 677 E D + + AK +CP+CG +D+ + PK Sbjct: 649 EEISDVDCDKCGAKMVYRQGPYGRYLKCPECGQNKAIVIDTGIECPKCHEGHLVKRRSKR 708 Query: 678 -RKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE-CEKCGSEMHLKMGRFGK--YMACTN 733 R + C P CD + +D P+ E C CG+ + +K R K + C+N Sbjct: 709 GRYFYGCSRYPACD----------MAVWDEPVNEFCSVCGA-IKVKKVRKNKEEELICSN 757 Query: 734 EEC 736 EC Sbjct: 758 PEC 760 Score = 53.1 bits (126), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 32/74 (43%), Positives = 42/74 (56%), Gaps = 8/74 (10%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD 767 V CEKCG+ M +KM R+GKY+AC N CKN K GE KE+ + ++ C+K Sbjct: 608 VICEKCGAHMIVKMSRYGKYLACPNFPSCKNI-KPYHTGE---EKEE---ISDVDCDKCG 660 Query: 768 AYFVLRDGAAGVFL 781 A V R G G +L Sbjct: 661 AKMVYRQGPYGRYL 674 >UniRef50_D1B572 DNA topoisomerase n=7 Tax=Campylobacterales RepID=D1B572_SULD5 Length = 694 Score = 472 bits (1215), Expect = e-131, Method: Compositional matrix adjust. Identities = 292/746 (39%), Positives = 408/746 (54%), Gaps = 71/746 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+IVESP KAKTI +LG +Y V +S GHIRDLP S K Sbjct: 6 KNLIIVESPTKAKTIKNFLGKNYTVVASKGHIRDLPKSSFGIK----------------- 48 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 ++ P Y V VV E+K+LA++AD +Y+ATD DREGEAI +H Sbjct: 49 -----IDNQTFIP------EYRVPKDHASVVKEIKELAKEADQVYIATDEDREGEAIGFH 97 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 + IG D R+VF+EITKNAI A P L+ +NAQQARR +DR+VGY +SPL Sbjct: 98 IATAIGKDPKSLPRIVFHEITKNAITHALENPRILDESSINAQQARRLLDRIVGYKLSPL 157 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 L KI +GLSAGRVQS +++VV+RE+EI+AF EEFW +DA + EA ++ + Sbjct: 158 LSSKIQKGLSAGRVQSSTLKIVVDREKEIRAFKEEEFWSIDA-LFNKTIEASLVEFEGEK 216 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 + N+E+ A L K + V E K S P F+TSTLQQ+AS+ LG+ K Sbjct: 217 IEKMSIGNQERAYAIKEKLLKEAFHVALLEKKERESSPSPAFMTSTLQQSASSALGYSPK 276 Query: 303 KTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 KTMM+AQ LYE G ITYMRTDS N+S++A+ R I +GK YLPE Sbjct: 277 KTMMLAQTLYEGVKTHQGVQGVITYMRTDSLNVSKEAIEAAREQILSQYGKTYLPEKARF 336 Query: 355 YASK-ENSQEAHEAIRPSDVNVM-AESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 YA+K + +QEAHEAIRP+ + A + + D KLY LI+ +F+A QM A+++S T Sbjct: 337 YANKSKGAQEAHEAIRPTILEFTPAIASAYLAPDELKLYALIYNRFLASQMNNARFESQT 396 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 L + + KA GR L FDG+ KV D+D++LP + +TL +L QHFT+ Sbjct: 397 LIFESQSGKFKASGRKLLFDGFYKVYG---DNDKDKLLPDLALKQEVTLSKLDANQHFTE 453 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PP+R+SEASL+K+LE GIGRPSTYA IS + R Y+ +E ++ ++ VT+ LE+ Sbjct: 454 PPSRYSEASLIKKLESLGIGRPSTYAPTISVLSARDYINIEKKQIVPTEVAFQVTELLEQ 513 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 +F ++++ FT+ ME LD +A + +W+A+L +F+ F Q+ K + + + + + Sbjct: 514 HFPQIVDSSFTSTMEERLDLIAEDKEDWQAILWNFYEPFDAQVAKGKTEIQSQKV----I 569 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 V T CP CG+++ R G F+ CS Y CK T NL V E E Sbjct: 570 VFTGEMCPECGKELVRRKGRFGEFIACSTYP-----TCKYTQNLK------KVSESAPKE 618 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 L CP+CG + + K CGN P C I Y+ +C Sbjct: 619 KVTLSVP--CPECGGEIIER-SSRRGKFFGCGNYPKCKF---------ISNYEPTDKKCP 666 Query: 713 KCGSEMHLKMGRFGKYMACTNEECKN 738 +CG M + R + C +CK+ Sbjct: 667 ECGYIMAKRELRKKEIYECI--KCKH 690 Score = 47.8 bits (112), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 42/81 (51%), Gaps = 4/81 (4%) Query: 711 CEKCGSEMHLKMGRFGKYMAC-TNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C +CG E+ + GRFG+++AC T CK T+ + + E AP ++ V L +PC + Sbjct: 576 CPECGKELVRRKGRFGEFIACSTYPTCKYTQNLKKVSESAP--KEKVTL-SVPCPECGGE 632 Query: 770 FVLRDGAAGVFLAANTFPKSR 790 + R G F +PK + Sbjct: 633 IIERSSRRGKFFGCGNYPKCK 653 >UniRef50_A8RBU5 DNA topoisomerase n=9 Tax=Bacteria RepID=A8RBU5_9FIRM Length = 718 Score = 470 bits (1210), Expect = e-131, Method: Compositional matrix adjust. Identities = 289/754 (38%), Positives = 417/754 (55%), Gaps = 90/754 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESP+K+KTI KYLG+DY+V SS GHIRDL T+G Sbjct: 2 KNLVIVESPSKSKTIEKYLGNDYMVVSSKGHIRDLATTGKGG------------------ 43 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +G+D H++E Y++ K VV ELK LA+K+DHIYLA+D DREGEAIAWH Sbjct: 44 --------LGIDVEHDFEPTYKISADKRSVVKELKDLAKKSDHIYLASDPDREGEAIAWH 95 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L +V+G D +R+VFNEITK A+ +A P ++I V +Q+ RR +DR++G+ +S L Sbjct: 96 LAQVLGLDVNDENRIVFNEITKGAVTEALKHPRTIDIPMVKSQETRRMLDRIIGFKLSKL 155 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 L KI + SAGRVQSVA+RL+VERE+EI+AF EE+W + A+ + + Sbjct: 156 LQSKI-KSKSAGRVQSVALRLIVEREQEIRAFKSEEYWTL-AALVDKDSKKFNANLIRIG 213 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K +++ A +S + + S +E+ K +P PFITSTLQQ AST+LGFG K Sbjct: 214 GKKAELKTQQEVDAIISRCHEFKVSSIEK--KVRKKEPRMPFITSTLQQEASTKLGFGAK 271 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 KTM +AQ+LYE G I+YMRTDST LS+ V YI D +GK Y + Sbjct: 272 KTMQIAQKLYEGIALQGGNAEGLISYMRTDSTRLSEQFVRDAEQYIEDTYGKAYCGRARQ 331 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 + + EN+Q+AHEAIRP+++ ES+K+ + D KLY+LI+ + +A M P+K + Sbjct: 332 K--NSENAQDAHEAIRPTNIQHTPESIKNYLTNDQYKLYKLIYARTLASLMAPSKSNVVN 389 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 + + D A G IL FDG+ K+ + +D +LP + +G+ L V L QHFT+ Sbjct: 390 AIIVSEDCEFSANGSILAFDGYLKIYHDY-ETVKDEMLPVLEEGEKLEKVRLEGKQHFTE 448 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-------NRRFYAEKMGEI 525 PP R+SEA L+K+LE++GIGRPSTYA II T+Q RGYV +E + F+ + GE+ Sbjct: 449 PPLRYSEARLIKDLEEKGIGRPSTYAIIIDTLQARGYVSLEKSSEGSKTKVFFPSEQGEL 508 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 +L+E F L+N +TA+ME LD++A + + L F++ F L+ A + Sbjct: 509 TDAKLKEFFSNLINVTYTAEMEAKLDEIAANTLDNIEELKRFYAKFEPLLENAYEH---- 564 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 M ++ T CP CG ++ R G F+ C + C+ T Sbjct: 565 -MEKKELERTGELCPECGSELVYRVGRYGKFISCINFP-----SCRYT------------ 606 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR--KLHVCGNNPTCDGYEIEEGEFRIKG 703 + E+ E NA + CP CG+ M ++ R C N PTC + K Sbjct: 607 -KSEEEEENA--SDEVCPHCGSKM---VMKKGRYGSFLACSNYPTCKYIK------NNKP 654 Query: 704 YDGPI---VECEKCGSEMHLKMGRFG-KYMACTN 733 + P+ C +CG + + RFG ++ C+N Sbjct: 655 KEEPVPTGENCPECGHPLVKRKSRFGTTFVGCSN 688 >UniRef50_A6DJX4 DNA topoisomerase n=2 Tax=Bacteria RepID=A6DJX4_9BACT Length = 897 Score = 469 bits (1208), Expect = e-130, Method: Compositional matrix adjust. Identities = 273/605 (45%), Positives = 362/605 (59%), Gaps = 63/605 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESPAKAKTI K LG D+ VK+S GH+RDLP Sbjct: 4 KNLVIVESPAKAKTIEKILGKDFEVKASFGHVRDLPQ----------------------- 40 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 ++GVDP +++E Y+V K+KV++ELK A+ ++IYLA D DREGEAIAWH Sbjct: 41 ------RKLGVDPDNDFEPEYQVSADKKKVIAELKSSAKNCENIYLAPDPDREGEAIAWH 94 Query: 123 LREVIGGDD-ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 L E++ A + RV FNEITK+AI+ AF+K ++++ RV+AQQARR +DR+VGY VSP Sbjct: 95 LYEILKKQSKAEFKRVTFNEITKSAIKSAFDKAHDVDMHRVDAQQARRILDRLVGYKVSP 154 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLWK+ AR SAGRVQ+VA+RL+ ERE+ I+AF PEE+W + A + +A + Sbjct: 155 LLWKRNAR--SAGRVQTVALRLICEREKAIRAFTPEEYWSLQAELKNQAADAQSFISKLD 212 Query: 242 N---DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 KP P N+E + V LE +++ V + E K +P PFITSTLQQAAS+ L Sbjct: 213 KIDGKKPHIP-NEETSSKIVGELEGSQFRVKDIESKDRKKRPAPPFITSTLQQAASSNLR 271 Query: 299 FGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 F +TM +AQ+LYE AG ITYMRTDS ++++A N +++ +G ++ P Sbjct: 272 FSPSRTMSLAQKLYEGRDLGSEGTAGLITYMRTDSVAIAKEAQNAAIDFVNHIYGSEFSP 331 Query: 350 ESPNQYASKENSQEAHEAIRPSDVN----VMAESLKDMEADAQKLYQLIWRQFVACQMTP 405 + PN Y SK ++Q HEAIRP+DV MA L D D KLY LIW++FVA QM P Sbjct: 332 DKPNFYKSKNSAQGGHEAIRPTDVTRTPKKMAPYLND---DELKLYTLIWKRFVASQMVP 388 Query: 406 AKY--DSTTL---TVG-AGDFRLKARGRILRFDGWTKVMPALRKGDEDR-----ILPAVN 454 A Y DS T +G + ++ K G +L FDG+ KV G +D ILP + Sbjct: 389 ALYRQDSITFLPENIGMSHEYLFKITGSVLIFDGFMKVYNFSDDGSQDGESKDVILPQLK 448 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN 514 +G+ L++L P QHFT+PP RFSEA+LVKELE G+GRPSTYASII TIQDR YV + Sbjct: 449 EGEICDLLQLIPKQHFTEPPPRFSEATLVKELEANGVGRPSTYASIIRTIQDREYVFKDK 508 Query: 515 RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQ 574 R G D L L FTA ME LD+V + + EW +L F+S F Sbjct: 509 GRLNPSDKGMESCDFLITTLPSLFEVTFTAHMEELLDKVEHGDLEWTKMLGDFYSGFKDW 568 Query: 575 LDKAE 579 L+ A+ Sbjct: 569 LEDAK 573 >UniRef50_D1Y390 DNA topoisomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y390_9BACT Length = 767 Score = 468 bits (1204), Expect = e-130, Method: Compositional matrix adjust. Identities = 282/719 (39%), Positives = 393/719 (54%), Gaps = 91/719 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK LV+VESP KAKT+ K LGS YVVK+SVGHI DLP S Sbjct: 71 GKTLVVVESPTKAKTLTKILGSGYVVKASVGHIVDLPKS--------------------- 109 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 R+ +D ++++ Y ++ GK V EL+ A A I LA D DREGEAIAW Sbjct: 110 --------RLAIDIENDFKPEYILVKGKAPVKKELQAAAATAQKILLAADPDREGEAIAW 161 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ E++G D RV F+EIT +A+R A +P +++DRV+AQQARR +DR+VGY +SP Sbjct: 162 HVAELLGVDPKENCRVRFHEITADAVRNAVKEPAPIDMDRVDAQQARRVLDRLVGYTLSP 221 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLWKKI RGLSAGRVQSVA+ ++ ERE+EI+ FVP+++W V T G A L V + Sbjct: 222 LLWKKIRRGLSAGRVQSVALAILCEREQEIENFVPQDYWNVFVDATADDGRAYRLHVERE 281 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP----------TTSKPGAPFITSTLQQ 291 N R + + A+ L K R ++KP K APF TST+QQ Sbjct: 282 NG---RSLLSDGKTLAIDTLAKVRDIEKTLKEKPLIVASFTAKKNARKQPAPFKTSTMQQ 338 Query: 292 AASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 A++RLGF ++TM +AQ L+E G +TYMRTDS ++ +A++ R I Sbjct: 339 IAASRLGFSPRRTMGIAQSLFEGVAIPGHGTVGLVTYMRTDSLRMAPEALSQARKVIEGR 398 Query: 343 FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 +GKKYLP Y + N+Q+AHEAIRP+D + ES+++ + A+ +LY +IWR+ VA Sbjct: 399 WGKKYLPAKAVVYQAGANAQDAHEAIRPTDFALTPESIRESLTAEQYRLYDMIWRRSVAS 458 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTL 461 QM PA DS TL G + L+A+G + FDGW V K D ++ +G+ L + Sbjct: 459 QMAPAVVDSATLDCECGKYGLRAQGASVGFDGWGAVWDLDVK---DAMIQKAREGELLNI 515 Query: 462 VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV-RVENRRFYAE 520 + + TKPPARF+E++L+K LE GIGRPSTYA+I+ T+ DR YV R E R+ Sbjct: 516 RNVQSEKEQTKPPARFTESTLIKTLEDDGIGRPSTYATIVETLYDRSYVAREEGRKLKPS 575 Query: 521 KMGEIVTDRLEENF-----RELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 ++G V L E+F +++ FT+ ME+SLDQV + + W ++ F+ FT + Sbjct: 576 ELGRSVNKFLLEHFDGKSTSPIVDVGFTSSMESSLDQVESGKKNWVELIGQFWKPFTDAI 635 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 +AEK P P LT CP CGR + + G F+GCSG+ Sbjct: 636 AEAEKAPVVPPPPPE---LTGETCPQCGRPLVKKQGRFGDFIGCSGF------------- 679 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK----RKLHVCGNNPTCD 690 PE + ++ E CPKCG ++ K R + C P CD Sbjct: 680 --PECHYIKPVQKEIGVP--------CPKCGNEHGGQVVQRKSKKGRTFYGCSRYPDCD 728 >UniRef50_Q256J1 DNA topoisomerase I-fused to SWI domain n=18 Tax=Chlamydiales RepID=Q256J1_CHLFF Length = 862 Score = 468 bits (1203), Expect = e-130, Method: Compositional matrix adjust. Identities = 296/821 (36%), Positives = 428/821 (52%), Gaps = 133/821 (16%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+L++VESPAK KT+ K LG ++ SS+GH+ DLP Sbjct: 1 MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLPA--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 G+D H++E Y++LP K++V++++ +LA D +YL+ D DREGEAIA Sbjct: 40 --------KTFGIDIEHDFEPDYQILPDKQEVINQICKLASSCDVVYLSPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ + + + RV FN ITK A+ +A P E+++ VNAQQARR +DR+VGY +S Sbjct: 92 WHIANQLP-KNTQIQRVSFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKIS 150 Query: 181 PLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP-SGEALALQ 237 P+L +K+ + G+SAGRVQSVA++LVV+RE+ I+AFVP E+W + P + + Sbjct: 151 PILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIRVFLQDPKTSKTFWAH 210 Query: 238 VTHQNDKPFRP-------------VNKE-QTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 + + K + +N E + Q LLE A Y V E K P Sbjct: 211 LYSADGKKWEKELPKGKTEDEILLINSEAKAQHYAELLEDASYRVTRVEAKEKRRNAAPP 270 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNM 334 FITSTLQQ AS F KTM +AQ LYE G ITYMRTDS + +A+N Sbjct: 271 FITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNN 330 Query: 335 VRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQL 393 VR YI D FG++YLP++PN Y SK+ +Q+AHEAIRP+D+++ + L+ + D LY L Sbjct: 331 VRDYIQDTFGQEYLPKTPNLYTSKKMTQDAHEAIRPTDIHLSPDKLQGKLTNDQHMLYSL 390 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAG-DFRLKARGRILRFDGWTKVMPALRKGD----EDR 448 IW++FVA QM PA YD+ +T+ L+A G +L+F G+ V D E+ Sbjct: 391 IWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKIDDDVAEEENP 450 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508 LP ++ D L +++ Q FTKP RF+EASLVKELEK GIGRPSTYA+I++ IQ R Sbjct: 451 SLPQLHAQDILDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSRE 510 Query: 509 YVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 Y EN+R ++G+I++ LE NF +M+ FTA ME+ L+ +A+++ WK +L F+ Sbjct: 511 YTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFW 570 Query: 569 SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRT-ASTGVFLGCSGYALPPK 627 F + AEK+ + P V+T IDC C + ++ A F GCS Y P+ Sbjct: 571 DQFLPVVTTAEKE----AVIPR--VVTDIDCSACHKGKLVKIWAKNRYFYGCSEY---PE 621 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNP 687 KT+ E E+ + ET CP CG Sbjct: 622 CDFKTS-----EEELAFNKDDYAVETP---WDSPCPVCG--------------------- 652 Query: 688 TCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNG 746 GE +++ GRFG ++ C N +C+ T + + G Sbjct: 653 ---------GEMKVRH-------------------GRFGTFLGCLNYPKCRGTISLHKKG 684 Query: 747 EVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFP 787 E E+P+P P + C S F R F + + +P Sbjct: 685 EEV-ETEEPIPCPAIGC--SGKIFKKRSRYNKTFYSCSEYP 722 >UniRef50_Q1UZD4 DNA topoisomerase n=4 Tax=Bacteria RepID=Q1UZD4_PELUB Length = 863 Score = 466 bits (1198), Expect = e-129, Method: Compositional matrix adjust. Identities = 266/652 (40%), Positives = 376/652 (57%), Gaps = 64/652 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LV+VESPAKAKTINKYLG DY+V +S GHIRDLP+ + Sbjct: 3 LVVVESPAKAKTINKYLGDDYIVLASYGHIRDLPSKNGS--------------------- 41 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 VDP +N++ +EV +K + E+ A+ + I LATD DREGEAIAWH++ Sbjct: 42 --------VDPENNFKMEWEVDSFSKKYLKEITDAAKISSKIILATDPDREGEAIAWHVK 93 Query: 125 EVIGGD----DARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 E + D RVVFNEITK A+ P ++ V+A ARR +D +VG+ +S Sbjct: 94 EYLNEKKLIKDKHIERVVFNEITKKAVIHGIENPRQIEPLLVDAYMARRALDYLVGFNIS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW K+ SAGRVQSVA++L+ ERE EI+ F PEEFW + ++ +T Sbjct: 154 PILWTKLPGSKSAGRVQSVALKLITEREHEIELFDPEEFWTLSIQFNDSDKNSILASITQ 213 Query: 241 QNDKP---FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 NDK F NK + A+ ++ +++ + K P PF TSTLQQ +S RL Sbjct: 214 LNDKKIEKFSFKNKAEIDKAMEEVKSKNFNINDISSKVVNRNPSGPFTTSTLQQVSSGRL 273 Query: 298 GFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 GFG +TM +AQ+LY+ G ITYMRTD TNLS DA++ R YI + FG +Y+P Sbjct: 274 GFGASRTMQIAQKLYQGIEIDGETIGLITYMRTDGTNLSTDAIDTFRKYIKNEFGDEYVP 333 Query: 350 ESPNQYASKE--NSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPA 406 ++ Y+ K+ N+QEAHEAIRP+D+ +++K + D KLY LIW + ++ QM PA Sbjct: 334 DNAASYSGKKAKNAQEAHEAIRPTDIMRAPDTVKKYLSPDQHKLYDLIWSRALSSQMKPA 393 Query: 407 KYDSTTLTVGAGD--FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 464 ++D T+T+ + D KA G +++FDG+ KVM +K D++ ILP +NKG + + L Sbjct: 394 QFDRNTITISSDDNGTICKASGSVIKFDGFLKVMKDTKKDDDEDILPEMNKG-PVNIESL 452 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 QHFT+PP R+SEASLVK+LE+ GIGRPSTYASIIS I RGY N+RF+ G+ Sbjct: 453 LDEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASIISVISTRGYAETINKRFHPTDRGK 512 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL-DKAEKDPE 583 +++ LE+ F + ++Y+FTA +EN LD + + W VL+ F+ DF Q + D EK Sbjct: 513 LISAFLEKLFSKYVDYNFTASLENQLDDITTGKEGWIKVLELFWKDFNQNVSDVKEKRTR 572 Query: 584 EGGMRPNQMVLTSI-----------DCPTCGR-KMGIRTA-STGVFLGCSGY 622 E N + + I C C + ++ + G F+GCS Y Sbjct: 573 EVLDLLNDSLGSLIFERDADGNINRQCKLCDSGSLSLKNSFRGGAFIGCSNY 624 >UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XK22_MEIRU Length = 836 Score = 464 bits (1195), Expect = e-129, Method: Compositional matrix adjust. Identities = 294/762 (38%), Positives = 422/762 (55%), Gaps = 106/762 (13%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L++VESPAKAK+I K LG+ Y V++S GHI DLP Sbjct: 6 LIVVESPAKAKSIQKMLGAGYEVRASKGHIADLPE------------------------- 40 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 + +GVD ++ Y V K+ +V ELK+ A + + +ATD DREGEAI WH+ Sbjct: 41 ----HELGVDTQADFAPQYTVKKDKQPIVEELKRAA-RGKRVLIATDPDREGEAIGWHVA 95 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 ++G + RV F+EIT +R A KP ++ V+AQQARR +DR+VGY +SP+L Sbjct: 96 RLLGLNPQTPLRVEFHEITPKVVRAAVQKPRPIDQSLVDAQQARRVLDRLVGYQLSPVLS 155 Query: 185 KKIAR-GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE------ALALQ 237 + R LSAGRVQSVA+RL+VERE+EI+AFVP+E W ++ + + +L + Sbjct: 156 MEFRRRALSAGRVQSVALRLLVEREQEIEAFVPQEHWSLEGRFESEGQQFKAMLYSLGSE 215 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKA---RYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 DK F +++Q Q L + R +ER ++ + P PFITSTLQQAAS Sbjct: 216 RVQSGDK-FLITSEKQAQEIARLAKDVSGYRIGSIERRERRRNAPP--PFITSTLQQAAS 272 Query: 295 TRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 +RLG+ +TM +AQ+LYE G ITYMRTDST +SQ+A+ VR +I +FG Sbjct: 273 SRLGWTASRTMRVAQKLYEGIDLPEGTVGLITYMRTDSTRVSQEALAEVRAFIPRHFGPA 332 Query: 347 YLPESPNQYASKE--NSQEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQLIWRQFVACQM 403 YLPE PN +A K+ N+Q+AHEAIRP+ ++L+ +D + +LYQLIW++FVA QM Sbjct: 333 YLPEKPNFFAGKKAANAQDAHEAIRPTSTERTPDALRKHLSDEEYRLYQLIWQRFVASQM 392 Query: 404 TPAKYDSTTLTV-GA-----GDFRLKARGRILRFDGWTKVMPALRKGDE-DRILPAVNKG 456 TPA +D TT+TV GA GD +A G +L+FDG+ +V +GDE + LP + + Sbjct: 393 TPAVFDQTTVTVVGASGTPSGDLIFRAVGSVLKFDGYLRVY-GREEGDEAENRLPPLQEN 451 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 + L+E+TP QHFT+PP R+++ASLVK LE+ GIGRPSTYA I T++ RGY+ + Sbjct: 452 ASARLLEVTPEQHFTEPPPRYTDASLVKTLEEMGIGRPSTYAPTIDTLERRGYLERSGKS 511 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 +G VT L ++F +++ YDFTAQ+E+ LD++ +A W V+ F+ F + Sbjct: 512 LKPTPLGREVTGYLIKSFPDVVAYDFTAQLESRLDEIEEGKAAWPKVVREFYEPFLKDFA 571 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 K P ++ CP CGR + ++ + G FLGC+GY CK T L Sbjct: 572 KV----------PQKL------CPKCGRPLELKVSRFGQFLGCTGYP-----ECKHTERL 610 Query: 637 VPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEE 696 + E + E CP CG + L+ R+ G+ +C Y E Sbjct: 611 ELKKEPEPIGEA-------------CPACG---EGQLV---RRHGRYGSFISCSRY--PE 649 Query: 697 GEFRIKGYDGPIVECEKC-GSEMHLKMGRFGK-YMACTNEEC 736 ++ +EC KC E+ K + GK Y C N C Sbjct: 650 CKYTRDEAPSTGIECPKCHAGEVVQKTSKRGKPYYRCNNPAC 691 Score = 52.4 bits (124), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 28/84 (33%), Positives = 47/84 (55%), Gaps = 8/84 (9%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C KCG + LK+ RFG+++ CT ECK+T ++ E+ K++P P+ E + Sbjct: 578 CPKCGRPLELKVSRFGQFLGCTGYPECKHTERL----EL---KKEPEPIGEACPACGEGQ 630 Query: 770 FVLRDGAAGVFLAANTFPKSRETR 793 V R G G F++ + +P+ + TR Sbjct: 631 LVRRHGRYGSFISCSRYPECKYTR 654 >UniRef50_C7NA27 DNA topoisomerase n=20 Tax=Fusobacteriaceae RepID=C7NA27_LEPBD Length = 800 Score = 462 bits (1189), Expect = e-128, Method: Compositional matrix adjust. Identities = 300/792 (37%), Positives = 439/792 (55%), Gaps = 87/792 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESP+KAKTI K LG +Y V +S GH+ DLP + Sbjct: 1 MARKLVIVESPSKAKTIEKILGRNYEVVASYGHVIDLPKT-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++G+D +N+E Y+V+ GK +V+ +LK+ A+ A+ +YLA+D DREGEAIA Sbjct: 41 ---------KIGIDVENNFEPQYKVIKGKGEVLKKLKEKAKSANAVYLASDQDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ I D + R+ FNEITK A+ A P ++N + VNAQQARR +DR+VGY +S Sbjct: 92 WHISNYIKQPD-KVKRIEFNEITKTAVNNAIKNPRDINDNLVNAQQARRLLDRIVGYKIS 150 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWK I R SAGRVQSVA++L+ + E EI AFVP+++WEV A L Sbjct: 151 PLLWKIINRNASAGRVQSVALKLICDLEDEINAFVPQKYWEVSALIEKDINLNLVKIANE 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + DK F +++ + L+ ++ + E K + +P F TSTLQQ AS+ LG+G Sbjct: 211 KVDKIF---DEKVVKKLKKDLKDESLTIEKIEVKKKSQRPPLVFKTSTLQQLASSYLGYG 267 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KTM +AQ+LYE G ITYMRTDST +S DA+NM + YI+ N+G+KY+ + Sbjct: 268 ASKTMRIAQQLYEGLPIDGENKGLITYMRTDSTRISVDALNMAKDYITKNYGEKYVGKYV 327 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQLIWRQFVACQMTPAKYDST 411 + SK N Q+AHE IRPSD+N++ + +K + Q +LY+LIW +F+ Q +Y+ Sbjct: 328 VK-NSKSNVQDAHEGIRPSDINLVPDDIKVYLTNEQYRLYKLIWDRFLVSQFAAMQYEQM 386 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI----LPAVNKGDALTLVELTPA 467 + GD+ + + FDG+ K+ DED I P + +G+ + +L Sbjct: 387 QINAVNGDYSFRGTINKVIFDGYYKIFK-----DEDEIKTGDFPELKEGNVHPIDKLNVE 441 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 + TKPP RFSEA+LVK+LE GIGRPSTYASI+ T++ R YV + +RFY +G V Sbjct: 442 EGITKPPTRFSEATLVKKLESEGIGRPSTYASIVETLKTREYVELIEKRFYPTYLGYEVK 501 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 D L +NF+++MN FTA ME LD+V EW +L F++ +++ K EK+ E Sbjct: 502 DELVKNFKDIMNVKFTANMEKELDKVEEGTVEWVQLLRAFYNSLEKEIKKFEKEIE---E 558 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFL----------GCSGYALPPKERCKTTINLV 637 N+ V++ + + G+ M ++T G +L G A+ P+E K I + Sbjct: 559 MKNRRVVSDV-LDSEGKPMILKTGLYGKYLISETNEKEKVSLKGIAVSPEELKKGEIFIK 617 Query: 638 PENEVL-NVLEG---EDAETNALRAKRRCPKCGTAMDS--YLIDPKR--------KLHVC 683 E E L N +G + + N R + + G ++S Y D KR + + Sbjct: 618 TEVEKLQNNKKGILTDYFDENGNRYVLKVGRFGEYLESENYEKDEKRMSLPAELKQKYKK 677 Query: 684 GNNPTCDG-YEIEEGEFRIKGYDGPIVE----CEKCGSEMHLKMGRFGKYMACTNE-ECK 737 G DG +I + R++ D I+E CE CG +K GRFGK++ACT ECK Sbjct: 678 GAVIELDGVLQINDEMKRLQEIDRKIIEEAGVCEFCGKPYEIKTGRFGKFLACTGYPECK 737 Query: 738 NTRKILRNGEVA 749 + I + G+V Sbjct: 738 TIKNI-KTGKVT 748 >UniRef50_D0GKB0 DNA topoisomerase n=1 Tax=Leptotrichia goodfellowii F0264 RepID=D0GKB0_9FUSO Length = 851 Score = 459 bits (1182), Expect = e-127, Method: Compositional matrix adjust. Identities = 296/785 (37%), Positives = 426/785 (54%), Gaps = 86/785 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 + K LVIVESP+KAKTI K LG Y V +S GH+ DLP + Sbjct: 14 LAKKLVIVESPSKAKTIEKILGKGYEVTASYGHVIDLPKT-------------------- 53 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++G+D +N+E Y+V+ GK +V+ +LK+ ++KA +YLA+D DREGEAIA Sbjct: 54 ---------KIGIDVENNFEPKYQVIKGKGEVLKKLKEKSKKASTVYLASDQDREGEAIA 104 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ I + + R+ FNEITK A+ A P ++N + VNAQQARR +DR+VGY +S Sbjct: 105 WHISNYIKQPE-KTKRIEFNEITKTAVNNAIKNPRDINKNLVNAQQARRLLDRIVGYKIS 163 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWK I + SAGRVQSVA++L+ + E EIK+FVP+++WEV A L + Sbjct: 164 PLLWKTINKNASAGRVQSVALKLICDLEDEIKSFVPQKYWEVGALLENGINLNLVEILKE 223 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + DK F ++E + L+ ++ E K T +P F TSTLQQ AS+ LG+G Sbjct: 224 KVDKIF---DEEVVKKLKKELKGKSLTLDSIEIKKKTQRPPLVFKTSTLQQLASSYLGYG 280 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KTM +AQ+LYE G ITYMRTDST +S DA+NM + YI++++GK+Y+ Sbjct: 281 ATKTMRIAQQLYEGLSINGENRGLITYMRTDSTRISMDAINMAKDYITNHYGKEYVGYYV 340 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 + SK N Q+AHE IRPSD+N+ E +KD + D KLY+LIW +F+ Q KY+ Sbjct: 341 TK-NSKSNVQDAHEGIRPSDINLDPEKIKDSLTNDQYKLYKLIWNRFLVSQFAAMKYEQM 399 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI----LPAVNKGDALTLVELTPA 467 + GD++ + + FDG+ K+ +ED I P + +GD+ + +L Sbjct: 400 QINAVNGDYKFRGTINKVIFDGYYKIFK-----EEDEIKTADFPELKEGDSYLIKKLNVE 454 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 + TKPP R+SEA+LVK+LE GIGRPSTYASI+ T++ R YV + +RF+ +G V Sbjct: 455 EGITKPPTRYSEATLVKKLESEGIGRPSTYASIVETLKTREYVEIIEKRFHPTFLGYEVK 514 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 + LE+NF ++MN FTA ME LD++ +W +L F+ L++ EK+ E+ Sbjct: 515 NELEKNFEDIMNVKFTAIMEEDLDKIEEGNVQWVELLKKFYDSLEIHLEQYEKEIEKLKD 574 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFL----------GCSGYALPPKERCKTTINLV 637 R + + S D G M ++T G +L G A+ ++ I + Sbjct: 575 RRIESDVLSSD----GSPMLLKTGRFGKYLVSETNPEEKITIKGIAVEAEQIEAGKIFIK 630 Query: 638 PENEVLNV----LEGEDAETNALRAKRRCPKCGTAMDS--YLIDPKR---------KLHV 682 E E L + + N R + + G ++S Y D KR K Sbjct: 631 EEVEKLQANKKGIPTDFFTENDKRYMLKKGRFGEYLESEDYENDEKRMSLPLPIKQKYKK 690 Query: 683 CGNNPTCDGYEIEEGEFRIKGYDGPIVE----CEKCGSEMHLKMGRFGKYMACTNE-ECK 737 N +I E I D I+E CEKCG +KMGRFGK++ACT ECK Sbjct: 691 GTLNEVNGVLQINEEITAIINEDKKIIEEAGVCEKCGRPFEIKMGRFGKFLACTGYPECK 750 Query: 738 NTRKI 742 N + I Sbjct: 751 NIKAI 755 >UniRef50_Q9X909 DNA topoisomerase 1 n=14 Tax=cellular organisms RepID=TOP1_STRCO Length = 952 Score = 459 bits (1182), Expect = e-127, Method: Compositional matrix adjust. Identities = 277/602 (46%), Positives = 357/602 (59%), Gaps = 52/602 (8%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ LVIVESPAKAKTI YLG YVV++SVGHIRDLP+ A+ P+K Sbjct: 11 GRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPSGA--------------AEVPEK 56 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 V R+GVD H+++ Y V K+ V +LK L +++D ++LATD DREGEAIAW Sbjct: 57 --YTGEVRRLGVDVEHDFQPIYVVNADKKSQVKKLKDLLKESDELFLATDEDREGEAIAW 114 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL+EV+ R+VF+EITK+AIR A P ELN V+AQ+ RR +DR+ GY VSP Sbjct: 115 HLQEVLK-PKIPVKRMVFHEITKDAIRAAVANPRELNQKLVDAQETRRILDRLYGYEVSP 173 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT--------PSGEA 233 +LWKK+ LSAGRVQSVA RLVVERERE AF E+W++ + T PS Sbjct: 174 VLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAGDASDPSSLV 233 Query: 234 LALQVTH----QNDKPFRPVNKEQTQAAVSL-----------LEKARYSVLEREDKPTTS 278 LQ + F + + ++ + L LE R++V E KP Sbjct: 234 ARLQTVDGRRVAQGRDFDSLGQLKSANTLHLDEANARALAAALENTRFAVRSVESKPYRR 293 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY 338 P APF T+TLQQ AS +LGFG K TM +AQ+LYE GYITYMRTDST LS AV+ R Sbjct: 294 SPYAPFRTTTLQQEASRKLGFGAKSTMQVAQKLYENGYITYMRTDSTTLSDTAVSAARAQ 353 Query: 339 ISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 ++ +G YLP P YA K +N+QEAHEAIRPS + + D KLY+LIW++ Sbjct: 354 VTQLYGADYLPPQPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKR 413 Query: 398 FVACQMTPAKYDSTTLTVGAG-----DFRLKARGRILRFDGWTKVM------PALRKGDE 446 VA QM A +S T+ +G D A G+ + F G+ K P D Sbjct: 414 TVASQMKDATGNSVTVKIGGAASDGRDVEFSASGKTITFHGFLKAYVEGADDPNAELDDR 473 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506 +R LP V +GDALT E+T H TKPPAR++EASLVKELE+R IGRPSTYASII TI D Sbjct: 474 ERRLPQVAEGDALTAEEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILD 533 Query: 507 RGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 RGYV + + V + LE++F L++YDFTA+ME+ LD++A EA+ L Sbjct: 534 RGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQSVPWLRR 593 Query: 567 FF 568 F+ Sbjct: 594 FY 595 >UniRef50_A6DDI1 DNA topoisomerase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DDI1_9PROT Length = 725 Score = 459 bits (1181), Expect = e-127, Method: Compositional matrix adjust. Identities = 288/750 (38%), Positives = 421/750 (56%), Gaps = 88/750 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP+KA+TI +LG +Y V +S GHIRDLP + K D Sbjct: 1 MAKKLIIVESPSKARTIKNFLGKEYEVIASKGHIRDLPKTSFGIKIEEDK---------- 50 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + Y V + V ELK+ A+KA+ IY+ATD DREGEAI Sbjct: 51 ------------------FIPQYRVTKDHQSVAKELKEKAKKAETIYIATDEDREGEAIG 92 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ VIG D + R+VF+EITK AI+ A P +L+IDRVNAQQARR +DR+VGY +S Sbjct: 93 FHIAHVIGKDPSSLPRIVFHEITKTAIKNALKNPRKLDIDRVNAQQARRLLDRIVGYKLS 152 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLL KKI +GLSAGRVQS A++LVV+REREIK F+P+E+W ++ G ++ Sbjct: 153 PLLNKKIQKGLSAGRVQSAALKLVVDREREIKEFIPKEYWSIEGIFKEVEGN--LIKYNG 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + F +++ + V+ L+ Y V + E K TT+K APF+TSTLQQ AS+ LGF Sbjct: 211 KKLEKFDLKTRDEAEKIVNELKPLEYEVSKIEKKTTTTKSPAPFMTSTLQQVASSELGFS 270 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 +KTM +AQ+LYE G ITYMRTDS N++++A +I +N G +Y E+ Sbjct: 271 PRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQEAAINFIKENIGSEY-AEAK 329 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 + +QEAHEAIRP DV + + LK+ + D KLY LI+ +F+A QM AK+++ Sbjct: 330 TYTTKNQTAQEAHEAIRPVDVRLTPDDLKNYLSKDELKLYSLIYNRFLASQMKDAKFETQ 389 Query: 412 T--LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 LT G+F++ G+ L FDG+ KV K D +LP +G+ L E+ QH Sbjct: 390 NIYLTNEKGEFKIS--GKKLIFDGFYKVYG---KRGADTLLPEFKEGEKLKPEEIKATQH 444 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FTKPP R++EASL+K+LE GIGRPSTYA I+ +Q+R YV +++++ + ++ V + Sbjct: 445 FTKPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEIKDKKLHPTEIAFNVIET 504 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA-EKDPEEGGMR 588 LE++F ++++ FTA ME LD++A +W+ +L F++ F + ++K E+ P + + Sbjct: 505 LEKHFPDIVDAKFTANMEEMLDEIARGNKDWQEMLKEFYNPFMKLIEKGYEEIPSQKIAK 564 Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 P T CP CG + IR G F+ CS + +CK T + E Sbjct: 565 P-----TGELCPECGNPLVIRKGRFGEFIACSNFP-----KCKYT---------RPIEEK 605 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKR-KLHVCGNNPTCDGYEIEEGEFRIKGYDGP 707 E+ + + +C KCG D + KR + C N P C K + P Sbjct: 606 EEKKVDV-----KCDKCGA--DMVIKRGKRGEFLACSNYPECKN---------TKPLNPP 649 Query: 708 ----IVECEKCGSEMHLKMGRFGKYMACTN 733 V+C +CG ++ + R G++ C N Sbjct: 650 EVLEDVKCPECGGDIIKRKSRRGEFYGCGN 679 Score = 52.8 bits (125), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 29/87 (33%), Positives = 50/87 (57%), Gaps = 11/87 (12%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C +CG+ + ++ GRFG+++AC+N +CK TR P +E ++ C+K A Sbjct: 570 CPECGNPLVIRKGRFGEFIACSNFPKCKYTR---------PIEEKEEKKVDVKCDKCGAD 620 Query: 770 FVLRDGAAGVFLAANTFPKSRETRAPL 796 V++ G G FLA + +P+ + T+ PL Sbjct: 621 MVIKRGKRGEFLACSNYPECKNTK-PL 646 >UniRef50_D0D7V2 DNA topoisomerase n=1 Tax=Citreicella sp. SE45 RepID=D0D7V2_9RHOB Length = 918 Score = 459 bits (1180), Expect = e-127, Method: Compositional matrix adjust. Identities = 271/690 (39%), Positives = 387/690 (56%), Gaps = 108/690 (15%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +V+VESPAKAKTINKYLGSDY V +S GH+RDLP + Sbjct: 3 VVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPAKDGS--------------------- 41 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 VD H++E +E+ K V+ + + + + + LATD DREGEAI+WHLR Sbjct: 42 --------VDTDHDFEMTWEIANDSRKHVAAIAEALKNDNSLILATDPDREGEAISWHLR 93 Query: 125 EVIGG-----DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 E + D SRV FN ITK+A+ +A P E++ V A ARR +D +VG+ + Sbjct: 94 EALTKRRSIKKDTAVSRVTFNAITKSAVTEAMQNPREIDAPLVEAYLARRALDYLVGFNL 153 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP+LW+K+ SAGRVQSV +RL+VERE EI+AF P E+W++ A +TP G+ ++T Sbjct: 154 SPVLWRKLPGARSAGRVQSVCLRLIVEREMEIEAFRPREYWQIKALLSTPRGQEYEARLT 213 Query: 240 HQNDKP---FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 K F N Q + AV + + + E +P+T P APF+TSTLQQ AS + Sbjct: 214 VLGGKKLDRFDIGNATQAELAVQAVASRKLKIDSVEARPSTRNPSAPFMTSTLQQEASRK 273 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 G G + M AQRLYEAG+ITYMRTD +++ +A+ R I+D +GK+Y+P SP Y Sbjct: 274 FGMGARACMNAAQRLYEAGHITYMRTDGIDMAPEAITACRDAIADRYGKEYVPGSPRIYK 333 Query: 357 SK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV 415 +K +N+QEAHE IRP+D+ A SLK E D +KLY LIW++ +ACQM A+ + TT+ + Sbjct: 334 NKAKNAQEAHECIRPTDMTRDAASLKLREDDQRKLYDLIWKRTLACQMEAARLERTTVEI 393 Query: 416 GAGDFR--LKARGRILRFDGWTKVMPALR---KGDEDRILPAVNKGD------------- 457 + D + L+A G+++ FDG+ KV R D++ LP + +G+ Sbjct: 394 LSEDRQVGLRATGQVVLFDGFLKVYEEGRDDVSDDDENRLPQIMEGEPAAFAKATLQAQY 453 Query: 458 ------ALTLVELTPA-------------------QHFTKPPARFSEASLVKELEKRGIG 492 A +VE PA Q T+PP R++EA+LVK +E+ GIG Sbjct: 454 DKASDKAEDVVEDAPAGMQKSSAAVLSDNGAVLATQSHTQPPPRYTEATLVKRMEELGIG 513 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 RPSTYAS+I+TIQDR YVR E R + E G IVT L FR+ + Y+FTA++EN LD+ Sbjct: 514 RPSTYASVITTIQDREYVRKEQNRLFPEDKGRIVTIFLLNFFRKYVGYEFTAELENELDE 573 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEK-------------------DPEEGGMRPNQMV 593 V+ E ++K++L F+ DF+ + + + P E G P Sbjct: 574 VSAGEMDYKSLLAKFWRDFSAAIGETSELRISEVLDVLDEALAPQLYPPREDGSDPRI-- 631 Query: 594 LTSIDCPTCGR-KMGIRTASTGVFLGCSGY 622 CP CG+ ++ ++T+ TG F+GC Y Sbjct: 632 -----CPKCGQGRLHLKTSRTGGFVGCGNY 656 >UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YFC7_DICT6 Length = 694 Score = 457 bits (1176), Expect = e-127, Method: Compositional matrix adjust. Identities = 284/752 (37%), Positives = 414/752 (55%), Gaps = 99/752 (13%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+IVESPAKAKTI K LG D+ V +S GHIRDLP Sbjct: 6 LIIVESPAKAKTIEKILGKDFKVLASYGHIRDLPE------------------------- 40 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +GVD + ++ Y +LP ++K++ +K L++K + +YLATD DREGEAIAWHL Sbjct: 41 ----KELGVDIENGFKPKYVLLPSRKKIIDTIKDLSKKVEKLYLATDPDREGEAIAWHLV 96 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 E + +++R+ F+EIT AI++A P ++++D+V AQQARR +DR+VGY +SPLLW Sbjct: 97 ETLKLPKDKFTRIEFHEITPRAIQEAIRNPRDIDLDKVEAQQARRILDRLVGYELSPLLW 156 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDK 244 +K+ RGLSAGRVQSVA++L+ ERE EI+ FVPEE+W + + + ++ ++ Sbjct: 157 EKVRRGLSAGRVQSVALKLICEREEEIEKFVPEEYWYIYGEFED-KDKIIYGKLVFYKEE 215 Query: 245 PFRPVNKEQTQAAVSLLEKARYS---VLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 N+++ + + +L Y V+ +E+K T P PFITSTLQQ AS RLGF V Sbjct: 216 EITIRNEKEAKRLIEVLNNLEYKIDRVVIKEEKKT---PPLPFITSTLQQEASRRLGFPV 272 Query: 302 KKTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 KTM +AQ LYE G ITYMRTDST ++ +A YI FGK+Y+ + Sbjct: 273 SKTMKIAQSLYEGVDIGDERVGLITYMRTDSTRIAPEAREEAVTYIESVFGKEYVGKERK 332 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 + K Q+AHEAIRP+ V E +K + D KLY+LIW +F+A QM A YD Sbjct: 333 E-RKKLGMQDAHEAIRPTSVLRTPEKVKKYLTEDQYKLYKLIWERFLASQMANALYDVIE 391 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI----LPAVNKGDALTLVELTPAQ 468 + + GD+ ++GR L+F G+ + + +E+ + +P +G + L+ LTP Q Sbjct: 392 IDIKGGDYTFVSKGRKLKFAGFMSLYTEKEEEEEEEVNVDYIP--QEGSDIDLINLTPKQ 449 Query: 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528 FT+PP R++EA+LV+ LEK GIGRPSTYA+II T+++R YV V + +G++V + Sbjct: 450 FFTQPPPRYTEATLVRTLEKYGIGRPSTYATIIETLKERKYVEVSKKELVPTTLGKVVNE 509 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 L + F L++ FTA+ME LD++ + E + VL+ F+ F ++L++ K+ G ++ Sbjct: 510 FLTKQFPHLIDVKFTAKMEEDLDKIESGEVKAIEVLEKFYPSFKEELERVSKN--FGKIQ 567 Query: 589 PNQMVLTSID--CPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVL 646 V+ D CP CGR++ IR G + CS Y CK T + E Sbjct: 568 ----VVEKTDEFCPICGRELVIRENKHGKYYACSAYP-----ECKYTKPIYEE------- 611 Query: 647 EGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHV-CGNNPTCDGYEIEEGEFRIKGYD 705 A +CP CG + K+ C N P C E Sbjct: 612 -----------AHGKCPLCGGIVVKKKARKTGKVFWGCINYPNCSFASPYE--------- 651 Query: 706 GPIVE-CEKCGSEMHLKMGRFGKYMACTNEEC 736 P+ E C +CGS + LK F K C+NE C Sbjct: 652 -PLDEKCPQCGSVL-LKGNGFKK---CSNENC 678 >UniRef50_O83409 DNA topoisomerase 1 n=4 Tax=Treponema RepID=TOP1_TREPA Length = 731 Score = 457 bits (1175), Expect = e-126, Method: Compositional matrix adjust. Identities = 281/767 (36%), Positives = 411/767 (53%), Gaps = 91/767 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESPAKA+TI KYLG+ YVV++S+GH+ DLP S Sbjct: 17 KHLVIVESPAKAQTIEKYLGTQYVVRASMGHVIDLPKS---------------------- 54 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 R+ +D H+++ Y + G+ + + EL+ L++++ ++LA+D DREGEAIA+H Sbjct: 55 -------RLAIDIEHDFQPEYITVRGRAQCLKELRTLSKQSLQVFLASDRDREGEAIAYH 107 Query: 123 LREVIGG-DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 L + I D R+VFNEIT +AIR A P ++ +VNAQ+ARR +DR+VGY + P Sbjct: 108 LAQSIQAYCDTPIKRIVFNEITPHAIRAAIGHPVPIDTAKVNAQKARRVLDRLVGYHLCP 167 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLW K+ GLSAGRVQSVA+RL+ ERE E+K FVPEE+W V+ + AL + Q Sbjct: 168 LLWHKVKNGLSAGRVQSVALRLICEREVEVKRFVPEEYWTVEGTFEKDKKSFSALLILIQ 227 Query: 242 NDKP-FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 K F+ +K++ +A+ L ++ V + +P PF TSTLQQ A+ RLGF Sbjct: 228 GKKAVFK--SKQEATSAIGLFSQSEARVSQIRSFEKNVRPKQPFTTSTLQQCAANRLGFT 285 Query: 301 VKKTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 +KTM +AQ+LYE G ITYMRTDS +S+ AV VR +I+ +F LP +P Sbjct: 286 SRKTMQVAQQLYEGVSLGTHRVGLITYMRTDSVRVSEAAVKEVRAWIATHFSDA-LPGTP 344 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTPAKYDST 411 N+YA+K SQ+AHEAIRP+ V E +K + D +LY LIW +FVA QMT A+ S Sbjct: 345 NRYAAKGKSQDAHEAIRPTYVAHTPERIKAHLTRDQIRLYTLIWERFVASQMTDARVRSL 404 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR-ILPAVNKGDALTLVELTPAQHF 470 T + AG A + G+ +V+ L D + +LP +G+ + L + QHF Sbjct: 405 TFEITAGPAVFSATETQVIEQGFYRVLKMLSPKDLSKAVLPPTKEGEVVALHNVQSVQHF 464 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+ P R+++AS+VK LE++GIGRPSTYA IS + DR YV ++ +G++++D L Sbjct: 465 TQGPVRYTDASIVKMLEEKGIGRPSTYAPTISVLLDRYYVTRIQKQLMPTPLGKVISDLL 524 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 F ++++ FTA+ME+ LD+V + +W V+ F+ F++++ KD MR Sbjct: 525 TTYFHDVVDVSFTARMESKLDEVEEDKIKWNCVIADFYPAFSEKVSTVMKD--LNSMRGV 582 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 T + C CG M + G FL C + P+ R + L Sbjct: 583 FDEKTDVVCSQCGDTMVKKLGRFGFFLACGKF---PECRNTQPVPLA------------- 626 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPK----RKLHVCGNNPTCDGYEIEEGEFRIKGYDG 706 +CP+ A D ++ K ++ + C P CD + + Sbjct: 627 ----------KCPR--PACDGNIVGKKTRGRKEFYGCTRFPVCDF---------VTHFKP 665 Query: 707 PIVECEKCGSEMHLKMG-RFGKYMACTNEECKN---TRKILRNGEVA 749 C +C + K R G Y AC N EC+ TRK L G+ A Sbjct: 666 TFAVCPQCRCFLVEKSNRRVGTYTACVNPECRYVSPTRKNLSLGKEA 712 >UniRef50_B1VM20 DNA topoisomerase n=6 Tax=Streptomyces RepID=B1VM20_STRGG Length = 963 Score = 455 bits (1170), Expect = e-126, Method: Compositional matrix adjust. Identities = 277/604 (45%), Positives = 356/604 (58%), Gaps = 54/604 (8%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ LVIVESPAKAKTI YLG YVV++SVGHIRDLP A+ P Sbjct: 11 GRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNG--------------AAEVP-- 54 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 DE V R+GVD H+++ Y V K+ V +LKQL ++D ++LATD DREGEAIAW Sbjct: 55 DEYTGEVRRLGVDVEHDFQPIYVVNADKKAQVRKLKQLLAESDELFLATDEDREGEAIAW 114 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL+EV+ R+VF+EITK+AIR A P ELN V+AQ+ RR +DR+ GY VSP Sbjct: 115 HLQEVLR-PKVPVHRMVFHEITKDAIRAAVANPRELNQRMVDAQETRRILDRLYGYEVSP 173 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT--------PSGEA 233 +LWKK+ LSAGRVQSVA RLVVERERE AF E+W++ T PS Sbjct: 174 VLWKKVMPKLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGKFATGRTGDASDPSNLT 233 Query: 234 LALQVTH----QNDKPFRPVNKEQTQAAVSL-------------LEKARYSVLEREDKPT 276 L + F P + + +A +L L + ++V E KP Sbjct: 234 ARLSAVDGRRIAQGRDFGPDGQLKAGSAQTLHLDETNARALAAALADSSFTVRSVESKPY 293 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 P APF T+TLQQ AS +LGFG K TM +AQ+LYE G+ITYMRTDST LS AV R Sbjct: 294 RRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSDTAVAAAR 353 Query: 337 GYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 ++ +G YLPE P YA K +N+QEAHEAIRPS + + D +LY+LIW Sbjct: 354 AQVTQLYGASYLPEKPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIW 413 Query: 396 RQFVACQMTPAKYDSTTLTVG--AGDFR---LKARGRILRFDGWTKVM------PALRKG 444 ++ VA QM A +S T+ +G A D R A G+ + F G+ K P Sbjct: 414 KRTVASQMKDATGNSVTVKIGGRASDGRDAEFSASGKTITFHGFMKAYVEGADDPNAELD 473 Query: 445 DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTI 504 D +R LP V +GDAL+ E+T H TKPPAR++EASLVKELE+R IGRPSTYASII TI Sbjct: 474 DRERRLPQVAEGDALSADEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTI 533 Query: 505 QDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 DRGYV + + V + LE++F L++YDFTA+ME+ LD+++ EA+ L Sbjct: 534 LDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRISRGEAQSVPWL 593 Query: 565 DHFF 568 F+ Sbjct: 594 KRFY 597 >UniRef50_B8E2F6 DNA topoisomerase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8E2F6_DICTD Length = 696 Score = 454 bits (1169), Expect = e-126, Method: Compositional matrix adjust. Identities = 283/749 (37%), Positives = 407/749 (54%), Gaps = 91/749 (12%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+IVESPAKAKTI K LG ++ V +S GHIRDLP Sbjct: 6 LIIVESPAKAKTIEKILGKEFKVLASYGHIRDLPE------------------------- 40 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +GVD +N++ Y +LP ++K++ +K L++KA+ +YLATD DREGEAIAWHL Sbjct: 41 ----KELGVDIENNFKPKYVLLPSRKKIIDTIKDLSKKAEKLYLATDPDREGEAIAWHLV 96 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 E + +++R+ F+EIT AI +A P E+++DRV AQQARR +DR+VGY +SPLLW Sbjct: 97 EELKLPKEKFTRIEFHEITPRAILEAIKNPREIDLDRVEAQQARRILDRLVGYELSPLLW 156 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDK 244 +K+ +GLSAGRVQSVA+R + ERE EI+ F+PEE+W + + L ++ D+ Sbjct: 157 EKVRKGLSAGRVQSVALRFICEREEEIEKFIPEEYWYIYGEFRDEE-KVLYGKLILYKDE 215 Query: 245 PFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKT 304 N+++ + +L Y + + K P PFITSTLQQ AS R GF V KT Sbjct: 216 EVNVKNEQEVNKIIRILNCLDYRIDKVVIKEEKRTPPPPFITSTLQQEASKRFGFPVGKT 275 Query: 305 MMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 M +AQ LYE G ITYMRTDST ++ +A YI FGK+Y+ + ++ Sbjct: 276 MKIAQSLYEGVDIGNERIGLITYMRTDSTRIAPEAREEAVQYIESGFGKEYVGKE-HKEK 334 Query: 357 SKENSQEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQLIWRQFVACQMTPAKYDSTTLTV 415 K Q+AHEAIRP+ V E ++ D Q K+Y+LIW +F+A QM A ++ + + Sbjct: 335 KKLGVQDAHEAIRPTSVFRDPEKIRKYLTDEQFKIYKLIWERFIASQMNHAIFEVVEIYI 394 Query: 416 GAGDFRLKARGRILRFDGWTKV-MPALRKG---DEDRILPAVNKGDALTLVELTPAQHFT 471 GD+ ++G+ L+F G+ + M G DE I +G + L L P Q FT Sbjct: 395 KGGDYVFLSKGKKLKFAGFMSLYMEKEENGEEKDEVNIDYVPEEGKNVKLTTLIPRQFFT 454 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 +PP R++EA+LV+ LEK G+GRPSTYA+II T+++R YV V++R +G++V D L Sbjct: 455 EPPPRYTEATLVRTLEKYGVGRPSTYATIIETLKERKYVEVKDRTLVPTTLGKVVNDFLT 514 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 + F L++ FTA+ME LD++ + + + VL F+ F ++L+K K+ G ++ Sbjct: 515 KQFPHLIDVKFTARMEEDLDKIESGKVKAIEVLKKFYPAFKEELEKVSKNI--GKIQ--- 569 Query: 592 MVLTSID--CPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE 649 V+ D CP CG K+ IR G + CS Y CK T + E Sbjct: 570 -VIEKTDEICPLCGSKLVIRENKNGKYYACSRYP-----ECKYTKPIYEE---------- 613 Query: 650 DAETNALRAKRRCPKC-GTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 A+ RCP C G + K+ C N P C E P+ Sbjct: 614 --------AQGRCPLCGGVVVKKKAKKTKKTFWGCINYPECSFASPYE----------PL 655 Query: 709 VE-CEKCGSEMHLKMGRFGKYMACTNEEC 736 E C +CGS M LK F K C+N++C Sbjct: 656 NEKCPQCGSTM-LKGNGFKK---CSNKDC 680 >UniRef50_Q31J81 DNA topoisomerase n=6 Tax=Bacteria RepID=Q31J81_THICR Length = 835 Score = 452 bits (1163), Expect = e-125, Method: Compositional matrix adjust. Identities = 260/611 (42%), Positives = 366/611 (59%), Gaps = 73/611 (11%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKAKTI KYLG + V+SS GHIRD+ G Sbjct: 4 LVIVESPAKAKTIEKYLGKGFTVRSSYGHIRDIQKKG----------------------- 40 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 MG+D + + +YE+ P K+K V+EL++L ++A+ ++LATD DREGEAIAWHL Sbjct: 41 ------MGIDIENGFMPNYEISPDKKKTVTELRKLTKEAETVWLATDEDREGEAIAWHLA 94 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 E + D R+VF+EITK AI++A +P ++++D V AQQARR +DR+VG+ +SP+LW Sbjct: 95 EALKLDVNDTKRIVFHEITKTAIQKAIAEPRKVDMDLVEAQQARRILDRIVGFELSPILW 154 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD-ASTTTPSGEALALQVTHQND 243 KKI GLSAGRVQSVAVRL+VEREREI AF + + + A + + V + Sbjct: 155 KKIRTGLSAGRVQSVAVRLIVEREREIDAFESDYVYRLQGALDILDESQQVVGAVEVKRS 214 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 F+ +E+ QA + +++A +V + E+KP P APF TSTLQQ AS++LGF VK+ Sbjct: 215 AAFK--TEEEAQAYLEQVKEAALTVSQLEEKPAKKSPKAPFTTSTLQQEASSKLGFSVKQ 272 Query: 304 TMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE-NSQ 362 TMM+AQRLYE+G ITYMRTDS NLS++A+ I FG+ Y + +Y +K ++Q Sbjct: 273 TMMIAQRLYESGKITYMRTDSVNLSEEAIQKAHDEIVSEFGESY--STTRRYKTKNADAQ 330 Query: 363 EAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV---GAGD 419 EAHEAIRP+D +V + + E + Q+LYQLIWR+ +A QM A+ T + + G Sbjct: 331 EAHEAIRPTDFSVKSVT---GERNEQRLYQLIWRRAIASQMADAQLKRTNVDIALEGMPA 387 Query: 420 FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSE 479 +L A+G ++ FDG+ KV E + LP + G AL L EL Q F++PPAR++E Sbjct: 388 EKLVAKGEVITFDGFLKVYNLDDDAKEGQ-LPPLKVGQALKLGELLVRQSFSRPPARYNE 446 Query: 480 ASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR------------------------ 515 ASLV+ LE+ GIGRPSTYA I TIQ RGYV E+R Sbjct: 447 ASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVVKEDREGRQRDYRQLSLTVDGIDASTLTE 506 Query: 516 -------RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 + + + IVTD L ++F ++++Y FTA +E+ D +A + W+ +L F+ Sbjct: 507 TTGTEKNKLFPTDIAGIVTDFLVKHFGDVLDYKFTALVESEFDTIAQGKESWQEMLTKFY 566 Query: 569 SDFTQQLDKAE 579 F ++D AE Sbjct: 567 QQFHPRVDAAE 577 >UniRef50_A5CF60 DNA topoisomerase n=2 Tax=Orientia tsutsugamushi RepID=A5CF60_ORITB Length = 788 Score = 451 bits (1159), Expect = e-125, Method: Compositional matrix adjust. Identities = 250/649 (38%), Positives = 375/649 (57%), Gaps = 60/649 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+IVESPAKAKTINKYLGSD+ V +S GH+RDL Sbjct: 3 LLIVESPAKAKTINKYLGSDFQVVASYGHVRDL--------------------------- 35 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 L V P ++ YE+ P + + + LA+K++ IYLATD DREGE+I+WH+ Sbjct: 36 --LAKAGSVLPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATDPDREGESISWHIV 93 Query: 125 EVIGGDD--ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 EV+ A + R++FNEITK AI A +P ++N++ VNAQQARR +D +VG+ +SPL Sbjct: 94 EVLKEKKIFANFKRIIFNEITKKAIGDALQQPRDINLNLVNAQQARRSLDYLVGFSLSPL 153 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LW+K+ SAGRVQSV +RL+ ERE EI F+ +E+W + + E + ++ + Sbjct: 154 LWRKLPGCKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKLIEFD 213 Query: 243 D---KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 + F N+ Q Q V +E ++ V++ K P PFITS+LQQ A+ +LGF Sbjct: 214 GNKLEKFSITNQSQAQDIVKNIENQQFKVIDITRKQRKKSPPPPFITSSLQQEAAGKLGF 273 Query: 300 GVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 KKTM +AQ+LYE ITYMRTDS LS+D ++ R +IS +FG YLP Sbjct: 274 TAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNFISSSFGNNYLPRQ 333 Query: 352 PNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 + SK +N+QEAHEAIRP ++N+ E L + +E D KLY+LIW++ VACQM + Sbjct: 334 IRAFKSKVKNAQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQRTVACQMENVILN 393 Query: 410 STTLTVGAGD--FRLKARGRILRFDGWTKVMPALRKGDEDR-ILPAVNKGDALTLVELTP 466 ++ + + KA G + FDG+ KV + +E++ +LP +++ + + + + P Sbjct: 394 LESINFASFNQLHVAKATGSTIAFDGFYKVYKEINDEEENKKLLPNLSQNEVMQVKNILP 453 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 QHFT+PP R+SEA+LVK LE GIGRPSTYA+IIS +Q+R YV ++ +RF + G +V Sbjct: 454 KQHFTEPPPRYSEATLVKTLEDLGIGRPSTYATIISVLQERDYVILDQKRFIPQNKGRLV 513 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG 586 T L F++ + YDFTA++E+ LD +A W+ +L +F++ F + + E+ Sbjct: 514 TAFLTAFFKKYVEYDFTAKLEDQLDSIAKGMIGWQEILKNFWTGFNNNVQEIEQYKITDI 573 Query: 587 MRPNQMVLTSI------------DCPTCGR-KMGIRTASTGVFLGCSGY 622 + + +L++ C C K+ ++ + G FL C+ Y Sbjct: 574 IPQIETLLSNFLFPVQNGETDHKLCTLCKVGKLSLKLSKYGAFLACNNY 622 >UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria RepID=B8EMQ0_METSB Length = 977 Score = 447 bits (1151), Expect = e-124, Method: Compositional matrix adjust. Identities = 268/676 (39%), Positives = 380/676 (56%), Gaps = 85/676 (12%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +VIVESPAKAK+INKYLG Y V S GH+RDLP + Sbjct: 3 VVIVESPAKAKSINKYLGKGYEVYPSYGHVRDLPAKDGS--------------------- 41 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 VDP ++ ++V K ++E+ + + AD I LATD DREGEAI+WH+ Sbjct: 42 --------VDPDADFAMLWDVDVKSAKRLNEIARAVKDADKIILATDPDREGEAISWHVL 93 Query: 125 EVIGGD----DARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 EV+ D RVVFN ITK+A+ +A P ++++ V+A ARR +D +VG+ +S Sbjct: 94 EVLKAKKVLKDKPVERVVFNAITKSAVLEAMQHPRQIDVALVDAYLARRALDYLVGFNLS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW+K+ SAGRVQSVA+RLV +RE EI+AFV E+W + A T + ++ Sbjct: 154 PVLWRKLPGARSAGRVQSVALRLVCDRELEIEAFVAREYWSIVAHLRTQADAPFTARLVG 213 Query: 241 QNDKPFRPVNKEQTQAAVSL---LEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + K ++ A + LE A + V E E KP P APF TSTLQQ AS +L Sbjct: 214 ADGKKITRLDVGTGAEAAAFKTDLENATFRVAEIEAKPAKRHPSAPFTTSTLQQEASRKL 273 Query: 298 GFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 GF +TM +AQRLYE G ITYMRTD +L+ +A+ R I+ FG Y+P Sbjct: 274 GFAPARTMQLAQRLYEGADIDGETVGLITYMRTDGVDLAPEAITSARSVIARQFGDAYVP 333 Query: 350 ESPNQYASK-ENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMTPAK 407 ++P +Y K +N+QEAHEAIRP+D+ + ++ + +E D KLY+LIW + +A QM A+ Sbjct: 334 KAPRKYTVKAKNAQEAHEAIRPTDLARLPRAVARALEPDQAKLYELIWTRTIASQMESAE 393 Query: 408 YDSTTLTV----GAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI---LPAVNKGDALT 460 + TT+ + GA L+A G+++RFDG+ K+ R ++D LP + K + L Sbjct: 394 LERTTVDIEALAGARKLDLRATGQVVRFDGFLKLYQEGRDDEDDDESARLPDMAKDERLK 453 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 + QHFT+PP RF+EA+LVK +E+ GIGRPSTYAS ++ +++R YVR+E +R + E Sbjct: 454 RERIEADQHFTEPPPRFTEATLVKRMEELGIGRPSTYASTLAVLRERDYVRIEKKRLHPE 513 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF--------- 571 G +VT LE F + YDFTA +E LD+V+NHE +WK VL F+ DF Sbjct: 514 DKGRLVTAFLEAFFARYVGYDFTADLEEKLDRVSNHEIDWKQVLRDFWLDFSGALAGTKD 573 Query: 572 ---TQQLDKAEK-------DPEEGGMRPNQMVLTSIDCPTCGR-KMGIRTASTGVFLGCS 620 T+ LD+ + P+E G P CP+CG K+ ++ G F+GCS Sbjct: 574 LRTTEVLDRLNEILGPHIFPPKEDGSDPR-------GCPSCGEGKLSLKLGKFGAFIGCS 626 Query: 621 GYALPPKERCKTTINL 636 Y CK T L Sbjct: 627 NYP-----ECKFTRTL 637 >UniRef50_D0KVS8 DNA topoisomerase n=6 Tax=Gammaproteobacteria RepID=D0KVS8_HALNC Length = 834 Score = 447 bits (1151), Expect = e-124, Method: Compositional matrix adjust. Identities = 264/646 (40%), Positives = 373/646 (57%), Gaps = 63/646 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDL-PTSGSAAKKSADSTSTKTAKKP 59 M + LVIVESPAKAKTI KYLG Y V +S GH+RDL P G+ Sbjct: 1 MSQTLVIVESPAKAKTIKKYLGPGYEVLASYGHVRDLIPKDGA----------------- 43 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 VD H++ +Y ++ + V +K+ + +D + LATD DREGEAI Sbjct: 44 -------------VDTAHDFAMNYTLIDKNVRHVDAIKKALKSSDILLLATDPDREGEAI 90 Query: 120 AWHLREVIGG----DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 +WHLRE++ + RVVF EITK A+++A P +L+ID +NAQQARR +D +V Sbjct: 91 SWHLRELLAEAGLLKNKTAQRVVFYEITKKAVQEAVAHPRDLSIDLINAQQARRALDYLV 150 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV------DASTTTP 229 G+ +SPLLWKKI GLSAGRVQS A+RL+VERE EI+AF P+E+W + D + Sbjct: 151 GFNLSPLLWKKINPGLSAGRVQSPALRLIVEREAEIEAFNPQEYWTILADCQADRAAEKS 210 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVS-LLEKARYSVLER--EDKPTTSKPGAPFIT 286 A L + Q + F N+ Q+A S +LE A ++ R E + P PF T Sbjct: 211 RFNARLLTLDGQKAEQFTLTNETDAQSARSRILEAAAGTLTVRSVEKRERKRNPAPPFTT 270 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGY 338 STLQQ +LG + M +AQ LYE G ITYMRTD+ LS+DA+ +R + Sbjct: 271 STLQQEGVRKLGLSASRVMRLAQELYEGVDIGAGTVGLITYMRTDAVTLSEDALTQIRAH 330 Query: 339 ISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWR 396 I D +G YLP SPN+Y +K +N+QEAHEAIRP+ +S++ + D +LY++I++ Sbjct: 331 IGDKYGAAYLPASPNRYKTKSKNAQEAHEAIRPTSAAHTPDSVRAFLNKDQFRLYEMIFK 390 Query: 397 QFVACQMTPAKYDSTTLTVGAGD-FRLKARGRILRFDGWTKVM-----PALRKGDEDRIL 450 + VA QMTPA YD ++ + D +A G L+F G+ + A DEDR L Sbjct: 391 RAVASQMTPAVYDQVSVDLAVNDQHSFRANGSTLKFPGFIALYREDEDDASGDNDEDRRL 450 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 P + GD + L ++ QHFT+PP RF+EASLVK LE+ GIGRPSTYASIIST+Q R YV Sbjct: 451 PPLTVGDKIALNDIAADQHFTEPPPRFTEASLVKTLEEYGIGRPSTYASIISTLQAREYV 510 Query: 511 RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 ++ RRF MG +V L + FR++++Y+FTA++E+ LD V+ E +W ++ F++ Sbjct: 511 LLDQRRFKPTDMGRVVNGFLTDYFRDIVDYEFTAKLEDDLDAVSRGERDWVPLMREFWTP 570 Query: 571 FTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVF 616 F +++ ++ Q ID P G+ + +R G F Sbjct: 571 FHDRVEHTNENVTR--QEAAQGRELGID-PKSGKPVSVRLGRFGPF 613 >UniRef50_B1M0P4 DNA topoisomerase n=14 Tax=Alphaproteobacteria RepID=B1M0P4_METRJ Length = 894 Score = 447 bits (1149), Expect = e-123, Method: Compositional matrix adjust. Identities = 267/669 (39%), Positives = 381/669 (56%), Gaps = 71/669 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +V+VESPAKAKTINKYLG DY V +S GHIRDLP PK Sbjct: 3 VVVVESPAKAKTINKYLGRDYEVIASFGHIRDLP--------------------PKDGS- 41 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 VDP ++ +E+ VSE+ + + AD + LATD DREGEAI+WH+ Sbjct: 42 --------VDPEQDFRMVWELADRGASRVSEIAKAVKGADKLILATDPDREGEAISWHVL 93 Query: 125 EVIGGDDAR----YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 E + A RV FN ITK ++ QA KP E++ V+A ARR +D +VG+ +S Sbjct: 94 EALTARKALKGIPVERVTFNAITKASVEQAMRKPREIDQALVDAYLARRALDYLVGFNLS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW+K+ SAGRVQSVA+RLVVERE EI+ F P E+W + A+ TT G ++ Sbjct: 154 PVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEARLVG 213 Query: 241 QNDKPFRPVNKEQTQAAVSL---LEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + K + ++ + A + LE A + V E KP P PF TSTLQQ AS +L Sbjct: 214 ADGKRIQRLDVGTGEEAAAFRRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQEASRKL 273 Query: 298 GFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 G +TM +AQRLYE G ITYMRTD +++ +A+ R I FG +Y+P Sbjct: 274 GMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDARRVIGKEFGDRYVP 333 Query: 350 ESPNQYASK-ENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMTPAK 407 + P +Y+ K +N+QEAHEA+RP+D+ + +++ + +E + +LY+LIW + +A QM A+ Sbjct: 334 DVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIWTRTMASQMESAE 393 Query: 408 YDSTTL----TVGAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGDALT 460 + TT+ VG L+A G++++FDG+ + + +E R LP + GD LT Sbjct: 394 LERTTVDVTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPPMKAGDPLT 453 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 ++ QHFT+PP R+SEASLVK +E+ GIGRPSTYA+++ T++DR YV++E +R E Sbjct: 454 RERISATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPE 513 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF------TQQ 574 G +VT LE FR + YDFTA +E LD+V+N E +W+AVL F+ DF T++ Sbjct: 514 DKGRLVTGFLESFFRRYVEYDFTAGLEEQLDRVSNAEIDWRAVLRDFWRDFSAAIGETKE 573 Query: 575 LDKAEKDPEEGGMRPNQMVLTSID------CPTCGR-KMGIRTASTGVFLGCSGYALPPK 627 L A+ G+ + D CPTCG ++ ++ G F+GCS Y Sbjct: 574 LRVADVLEALNGLLGPHIFPDKGDGSNPRTCPTCGSGQLSLKLGKFGAFIGCSNYP---- 629 Query: 628 ERCKTTINL 636 CK T L Sbjct: 630 -ECKYTRQL 637 >UniRef50_C6P2V7 DNA topoisomerase n=2 Tax=Proteobacteria RepID=C6P2V7_9PROT Length = 876 Score = 446 bits (1146), Expect = e-123, Method: Compositional matrix adjust. Identities = 282/709 (39%), Positives = 397/709 (55%), Gaps = 72/709 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDL-PTSGSAAKKSADSTSTKTAKKP 59 M L+IVESPAKAKT+ KYLG D+ V +S GH+RDL P +G+ Sbjct: 1 MATNLLIVESPAKAKTLKKYLGKDFEVLASYGHVRDLIPKTGA----------------- 43 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 VDP N+ YE + K V + + A +ADHI+LA D DREGEAI Sbjct: 44 -------------VDPDDNFAMKYETIARNAKHVDAIAKAAAEADHIFLAPDPDREGEAI 90 Query: 120 AWHLREVIGGDDA----RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 AWH+ E++ G A RVVF EIT++A+R+A P E++I VNAQQARR +D +V Sbjct: 91 AWHISELLKGKRALKGKTMQRVVFYEITQSAVREAVAHPREISIPLVNAQQARRALDYLV 150 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV--DASTTTPSGEA 233 G+ +SPLLW+KI GLSAGRVQS A+RL+VERE EI+ F +E+W V D+ + +A Sbjct: 151 GFNLSPLLWRKIRPGLSAGRVQSPALRLIVERELEIEKFKSQEYWSVHLDSQKNSIPFKA 210 Query: 234 LALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY--SVLEREDKPTTSKPGAPFITSTLQQ 291 Q + + ++ + A + L A+ V+ E K P APF TSTLQQ Sbjct: 211 KLYQFQGKRMEQLTIGSQAEYDAIHAKLVDAKLPPKVVRVEKKGKQRSPAAPFTTSTLQQ 270 Query: 292 AASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNF 343 A +LG +TM AQ LYE G ITYMRTDS NL+ +AV +R YI DNF Sbjct: 271 EAVRKLGMTSDRTMRTAQSLYEGVDIGGQTIGLITYMRTDSVNLANEAVAEMREYIKDNF 330 Query: 344 GKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 YLP Y SK +N+QEAHEAIRP+ + +SL+D + D +LY++IW++ +A Sbjct: 331 AGDYLPVKQPVYKSKSKNAQEAHEAIRPTSILRTPDSLRDHLNIDQMRLYEMIWKRTLAS 390 Query: 402 QMTPAKYDSTTLTV--GAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI---LPAVNKG 456 QM+PA++D+ ++ + + D +A G+ L F G+ V E+ LP + +G Sbjct: 391 QMSPARFDTVSVDIRLSSDDTLFRASGQTLVFPGFIGVYMEDVDDAEEEDSAKLPPLVEG 450 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 D L + +L QHFT+PP RFSEASLVK LE+ GIGRPSTYA+IIST+Q R Y ++ +R Sbjct: 451 DVLPVDKLYGEQHFTQPPPRFSEASLVKALEEYGIGRPSTYATIISTLQAREYATLDKKR 510 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 F +G +V L E+F ++Y FTA +E+ LD ++ + +W VL+ F+ F + + Sbjct: 511 FMPTDVGRVVIKFLNEHFTRYVDYGFTANLEDELDDISEGKRDWIPVLNEFWKGFNKLIS 570 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 + +KD + RP +L CP CG+ + R G F+GC+GY C T +L Sbjct: 571 E-KKDVD----RPGTEILEET-CPKCGKPLSKRLGKRGSFIGCTGYP-----ECDYTRSL 619 Query: 637 VPENEVLNVLE--GEDAETNALRAKRRCP-----KCGTAMDSYLIDPKR 678 E + + G+ +TN L R P + G ++ PKR Sbjct: 620 GGEEDAGESRKELGQHPDTNQLVLLLRGPYGPYVQLGEMIEGEKTKPKR 668 >UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q3SMS7_THIDA Length = 857 Score = 444 bits (1143), Expect = e-123, Method: Compositional matrix adjust. Identities = 271/663 (40%), Positives = 390/663 (58%), Gaps = 63/663 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP+K+K++ KYLG+DY + +S GH+RDL +P Sbjct: 4 LVIVESPSKSKSLKKYLGADYDILASYGHVRDL--------------------EP----- 38 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 R G N+ Y+++ K V + + A+KAD + LATD DREGEAI+WH+ Sbjct: 39 -----RTGAVDTENFSMKYQIIERNAKHVDAIVKAAKKADEVLLATDPDREGEAISWHIS 93 Query: 125 EVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 E++ + RV F EIT++AI+ A P E+ D V+AQQARR +D +VG+ +SPL Sbjct: 94 EILKEKKVKTPMKRVAFYEITESAIQDAVRNPREIASDLVDAQQARRALDYLVGFNLSPL 153 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH-- 240 LWKKI+ GLSAGRVQS A+R++VERE EI+AFV E+W + + S +A ++TH Sbjct: 154 LWKKISPGLSAGRVQSPALRMIVEREEEIEAFVAREYWTLHLDSHKGS-QAFTAKLTHFK 212 Query: 241 -QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 + F ++ +++ ++ LE V+ E K P APF TSTLQQA +LG Sbjct: 213 GEKLDQFAVEHEARSKEWLATLESKDARVMRIEKKRRARNPAAPFTTSTLQQAGVRQLGM 272 Query: 300 GVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 + M AQ+LYE G ITYMRTDS NL+Q+A+ +R Y+ NF K YLP Sbjct: 273 TTDRVMRTAQQLYEGIDLGEGPVGLITYMRTDSVNLAQEAITDIRKYVGANFDKDYLPPH 332 Query: 352 PNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 QY +K +N+QEAHEA+RP+ V ++++ + D +LY+L+W++ VACQMT A++D Sbjct: 333 AVQYKAKTKNAQEAHEAVRPTSVLRTPDAVRQFLTQDQARLYELVWKRTVACQMTAAQFD 392 Query: 410 STT--LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 + +TVG G FR A G+ L F G+ V + + LPA+ +G+ L + L Sbjct: 393 TVAADITVGEGTFR--ATGQTLAFAGFLAVYQDDEDDEGESKLPALVEGETLPVDRLYGE 450 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFT+PP R++EASLVK LE+ GIGRPSTYASIIST+QDR YV +E +RF +G +V Sbjct: 451 QHFTQPPPRYTEASLVKALEEYGIGRPSTYASIISTLQDREYVVLEKKRFQPTDVGRLVN 510 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 L +F ++YDFTA++E+ LD V+N + W +L F+S F L KA++D E G Sbjct: 511 CFLTRHFSHYVDYDFTAKLEDKLDDVSNGKRVWSRLLGEFWSGFEGDL-KAKQDVERGC- 568 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 +L + CP C + + ++ + G+F+GCSGY C T L P + + Sbjct: 569 ----PILEA--CPKCAKPLFMQASKRGLFIGCSGYP-----ECDYTRPLHPATAEGDNIL 617 Query: 648 GED 650 G+D Sbjct: 618 GKD 620 >UniRef50_Q9ZMV7 DNA topoisomerase 1 n=47 Tax=Epsilonproteobacteria RepID=TOP1_HELPJ Length = 736 Score = 444 bits (1142), Expect = e-123, Method: Compositional matrix adjust. Identities = 275/745 (36%), Positives = 414/745 (55%), Gaps = 75/745 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+IVESPAKAKTI +L +Y V +S GH+RDL +K A K D Sbjct: 2 KHLIIVESPAKAKTIKNFLDKNYEVVASKGHVRDL---------------SKFALGIKID 46 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 E G N + VD H +++V ++ +L++KA Y+ATD DREGEAI +H Sbjct: 47 ETGFTPNYV-VDKDH------------KELVKQIIELSKKASITYIATDEDREGEAIGYH 93 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 + +IGG Y R+VF+EIT+NAI P ++++ +VNAQQARR +DR+VG+ +S L Sbjct: 94 VACLIGGKLESYPRIVFHEITQNAILNVLKTPRKIDMFKVNAQQARRLLDRIVGFKLSSL 153 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 + KI +GLSAGRVQS A++LV++RE+EI+ F P ++ +DA P EA + Sbjct: 154 IASKITKGLSAGRVQSAALKLVIDREKEIRPFKPLTYFTLDA-LFEPHLEAQLISYKGNK 212 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K +++++ Q + LEK Y + K S PF+TSTLQQ+AS+ LGF Sbjct: 213 LKAQELIDEKKAQEIKNELEKESYIISSIIKKSKKSPTPPPFMTSTLQQSASSLLGFSPT 272 Query: 303 KTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 KTM +AQ+LYE G ITYMRTDS N++++A+ R I ++GK YLP Sbjct: 273 KTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARAKILKDYGKDYLPPKAKV 332 Query: 355 YASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 Y+SK +N+QEAHEAIRP+ + + +LKD ++ + KLY LI+++F+A QM A ++S + Sbjct: 333 YSSKNKNAQEAHEAIRPTSIILEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQS 392 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 + V KA GR L FDG K+ L D+D++LP + + D + L +L H T+ Sbjct: 393 VVVACEKGEFKASGRKLLFDGHYKI---LGNDDKDKLLPNLKENDPIKLEKLESNAHVTE 449 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PPAR+SEASL+K LE GIGRPSTYA IS +Q+R Y++VE ++ A + V + LE+ Sbjct: 450 PPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVIEILEK 509 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 +F E+++ F+A +E LD +A ++A+++ VL F+ F +++ +K+ + Sbjct: 510 HFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEK-- 567 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 T CP CG ++ + + G F+ C+ Y +CK + + E+A Sbjct: 568 --TGQSCPKCGGELVKKNSRYGEFIACNNYP-----KCKY------------IKQTENAN 608 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE----IEEGEFRIKGYDGPI 708 A + C KCG M C N P C + + I+G Sbjct: 609 DEA--KQELCEKCGGEMVQKF-SRNGAFLACNNYPECKNTKSLKNTPNAKETIEG----- 660 Query: 709 VECEKCGSEMHLKMGRFGKYMACTN 733 V+C +CG ++ LK + G + C N Sbjct: 661 VKCPECGGDIALKRSKKGSFYGCNN 685 Score = 50.1 bits (118), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 44/134 (32%), Positives = 55/134 (41%), Gaps = 20/134 (14%) Query: 660 RRCPKCGTAMDSYLIDPKRK---LHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE-CEKCG 715 + CPKCG L+ + C N P C + E D E CEKCG Sbjct: 570 QSCPKCGGE----LVKKNSRYGEFIACNNYPKCKYIKQTEN-----ANDEAKQELCEKCG 620 Query: 716 SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRD 774 EM K R G ++AC N ECKNT K L+N A + V PE + L+ Sbjct: 621 GEMVQKFSRNGAFLACNNYPECKNT-KSLKNTPNAKETIEGVKCPECGGD-----IALKR 674 Query: 775 GAAGVFLAANTFPK 788 G F N +PK Sbjct: 675 SKKGSFYGCNNYPK 688 Score = 44.3 bits (103), Expect = 0.022, Method: Compositional matrix adjust. Identities = 27/85 (31%), Positives = 42/85 (49%), Gaps = 10/85 (11%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C KCG E+ K R+G+++AC N +CK ++ + A EL CEK Sbjct: 572 CPKCGGELVKKNSRYGEFIACNNYPKCKYIKQTENANDEAKQ--------EL-CEKCGGE 622 Query: 770 FVLRDGAAGVFLAANTFPKSRETRA 794 V + G FLA N +P+ + T++ Sbjct: 623 MVQKFSRNGAFLACNNYPECKNTKS 647 >UniRef50_C6XXX5 DNA topoisomerase n=76 Tax=Bacteria RepID=C6XXX5_PEDHD Length = 857 Score = 444 bits (1142), Expect = e-123, Method: Compositional matrix adjust. Identities = 284/753 (37%), Positives = 406/753 (53%), Gaps = 108/753 (14%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKAKTI YLG D++VKSS GHIRDL Sbjct: 1 MAKNLLIVESPAKAKTIEGYLGKDFLVKSSYGHIRDL----------------------- 37 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + M +D +N+ YEV K++VV+ELK+LA+ A+ ++LA+D DREGEAI+ Sbjct: 38 ------VKGDMAIDTANNFAQTYEVPSDKKQVVAELKKLAKDAEMVWLASDEDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E +G + + R+VF+EITK AI +A P ++ + VNAQQARR +DR+VG+ +S Sbjct: 92 WHLYETLGLKENKTKRIVFHEITKPAILKAIETPRSIDYNLVNAQQARRVLDRLVGFELS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKKI LSAGRVQSVAVRL+V+RERE+ F +++ A T +G+ L Sbjct: 152 PVLWKKIKPSLSAGRVQSVAVRLIVDREREVNKFNAAAAFKITAEFVTGNGKELV----- 206 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + P R + + ++ A +SV E KP P APF TSTLQQ AS +LG+ Sbjct: 207 KAELPQRFEKEADAEKFLNDCAGAGFSVDSLETKPAKRNPAAPFTTSTLQQEASRKLGYS 266 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE- 359 V +TM +AQRLYE+G ITYMRTDS NLS+ A+ I +G KY P Y +K Sbjct: 267 VSRTMQIAQRLYESGRITYMRTDSVNLSETALQAAASEIRSAWGDKY--HQPRTYKTKSA 324 Query: 360 NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD 419 +QEAHEAIRP+ N + ++ Q+LY+LIW++ +A QM+ A ++ TT +G Sbjct: 325 GAQEAHEAIRPTYFN---QHTVPGDSSEQRLYELIWKRAIASQMSEALFEKTTAQIGIST 381 Query: 420 FR--LKARGRILRFDGWTKVMPALRKGDE--------DRILPAVNKGDALTLVELTPAQH 469 + L A G +L+FDG+ KV L DE + +LPA+++G ALTL + + Sbjct: 382 RKEQLIAEGEVLKFDGFLKVY--LESSDEEDAEDSEGNNMLPALSRGQALTLKVMNATER 439 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR-------------- 515 F++PPAR++EASLVK+LE+ GIGRPSTYA ISTIQ+RGYV E+R Sbjct: 440 FSRPPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVVKEDRDGRQRSFAAIELSN 499 Query: 516 -----------------RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 + + +GE+V D L E+F+ +++++FTA +E D++A Sbjct: 500 GSVTKKTKTEITGAEKGKLFPTDIGEVVNDFLVEHFKGIVDFNFTANVEKEFDEIAQGLQ 559 Query: 559 EWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG 618 EW +L F++ F +++ + E R N L +D P G+ + + G + Sbjct: 560 EWTKMLHSFYTPFHLEVE----NTLETADRANGERLLGLD-PATGKNVYTKVGRFGPLVQ 614 Query: 619 CSG--------YALPPKERCKTTINLVPENEVLNV---LEGEDAETNALRAKRRCP--KC 665 YA K + T+ L E + LE + ++ R P K Sbjct: 615 IGENDDEEKPRYASLSKSQSVGTVTLEEALEQFKLPFSLEDYQGKEVSVGVGRFGPYVKW 674 Query: 666 GTAM-------DSYLIDPKRKLHVCGNNPTCDG 691 G A D ID R + + G T D Sbjct: 675 GDAFISVPKNEDPLSIDQARAIEIIGEKITADA 707 >UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria RepID=B6RA74_9RHOB Length = 931 Score = 443 bits (1139), Expect = e-122, Method: Compositional matrix adjust. Identities = 285/786 (36%), Positives = 420/786 (53%), Gaps = 126/786 (16%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +VIVESPAKAKTINKYLG DY V +S GH+RDLP PK Sbjct: 3 VVIVESPAKAKTINKYLGKDYTVLASYGHVRDLP--------------------PKDGS- 41 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 V P ++ + V +K +SE+ ++AD + LATD DREGEAI+WH+ Sbjct: 42 --------VLPDDDFAMSWSVDSKSQKRLSEIASAVKEADRLILATDPDREGEAISWHVL 93 Query: 125 EVIGGDDAR----YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 EV+ RVVFN ITK++I +A P EL+ V+A ARR +D +VG+ +S Sbjct: 94 EVLKKKRVLKDKKIERVVFNAITKSSILEAMKNPRELDEPLVDAYLARRALDYLVGFTLS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW+K+ SAGRVQSVA+RLV +RE EI+ F +E+W + A+ TP + ++T Sbjct: 154 PVLWRKLPGARSAGRVQSVALRLVCQRENEIETFQSQEYWSILANLNTPENAPVQARLTG 213 Query: 241 QNDKPFRPVNKEQTQAAVS---LLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + ++ + Q A + +L+ A + V E KP P APF TSTLQQ AS +L Sbjct: 214 FDGQKITRLDIKNEQEATTIKQMLDGASFQVSNVESKPQRRNPYAPFTTSTLQQEASRKL 273 Query: 298 GFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 GF +TM +AQ+LYE G ITYMRTD ++Q+A+ RG I+ +G +Y+P Sbjct: 274 GFAAARTMQVAQKLYEGANIGGETTGLITYMRTDGVQIAQEAITSARGVIASRYGDEYVP 333 Query: 350 ESPNQYASK-ENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMTPAK 407 E P Y+SK +N+QEAHEAIRP+D+ + K ++ D +LY+LIW++ +A QM A Sbjct: 334 EKPRMYSSKAKNAQEAHEAIRPTDLTRHPRDMAKFLDEDGARLYELIWKRTIASQMESAV 393 Query: 408 YDSTTLTV----GAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGDALT 460 + TT+ + GA L+A G ++RFDG+ + + +E + LP + +GD+L Sbjct: 394 LERTTVDIDAVNGAKKAALRASGSVVRFDGFLTLYQEGKDDEEDEESKRLPPMTRGDSLG 453 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 + QHFT+PP RF+EA+LVK++E+ GIGRPSTYA+ + T++DRGYV ++ +R + Sbjct: 454 RKGIEANQHFTEPPPRFTEATLVKKMEELGIGRPSTYAATLQTLRDRGYVELDKKRLIPQ 513 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK 580 G +VT LE+ F + YDFTA +E+ LD+++ + EWKAVL F++ F + D+ K Sbjct: 514 DKGRLVTAFLEDFFNRYVEYDFTASLEDQLDKISAGDLEWKAVLRDFWNPFHEICDEVIK 573 Query: 581 DPEEGGMRPNQMVLTSID-------------------CPTCGR-KMGIRTASTGVFLGCS 620 R N VL +++ CP C ++ ++ + G F+GCS Sbjct: 574 -------RSNTEVLDALNETLKAHVFPDKEDGSDPRKCPKCDTGRLSLKVSRFGAFVGCS 626 Query: 621 GYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 Y K +G++ N P C D R+L Sbjct: 627 NYNKDKK-------------------DGKEPNENP-------PHC---------DYTRQL 651 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTR 740 G++ D +G ++ G D + G E+ L+ GRFG Y+ EE K R Sbjct: 652 TSGGDS---DAGAAADGP-QVLGID------PETGLEVSLRTGRFGPYVQL-GEEAKPKR 700 Query: 741 KILRNG 746 L G Sbjct: 701 SSLPRG 706 >UniRef50_A4CJB9 DNA topoisomerase n=4 Tax=Bacteria RepID=A4CJB9_9FLAO Length = 820 Score = 441 bits (1135), Expect = e-122, Method: Compositional matrix adjust. Identities = 283/710 (39%), Positives = 387/710 (54%), Gaps = 99/710 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI K+LG D+ V SS GHI DLP+ Sbjct: 1 MAKNLVIVESPAKAKTIEKFLGKDFKVTSSFGHIADLPS--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD ++ Y V K+ +V +LK+LA KA+ I+LA+D DREGEAI+ Sbjct: 40 --------RELGVDVDKDFSPKYVVDKEKKALVKKLKELASKAETIWLASDEDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E + D + R+VFN ITK+AI++A P ++N D VNAQQARR +DR+VGY +S Sbjct: 92 WHLAETLKLDADKTRRIVFNSITKSAIQKAIENPRKINYDLVNAQQARRILDRLVGYELS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKKI GLSAGRVQSVAVRL+VERER I+ F P+ ++V A T +G L ++ Sbjct: 152 PVLWKKIKPGLSAGRVQSVAVRLIVERERAIEEFEPQSSFKVAAEFRTENGATLPAKLNE 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 D + + Q ++ L A ++V + KP P APF TSTLQQ AS +L F Sbjct: 212 SFD------TETEAQEFLAGLANASFAVDSLDTKPAKKSPAAPFTTSTLQQEASRKLYFS 265 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 V +TM +AQRLYEAG ITYMRTDS +LS +A+ + I N+G+KY Q SK Sbjct: 266 VSRTMQVAQRLYEAGLITYMRTDSVSLSGEAIAAAKEEIVGNYGEKYSKVRKFQSKSK-G 324 Query: 361 SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV--GAG 418 +QEAHEAIRP+D M ++E D +LY+LI + +A QM+ A+ + T + + Sbjct: 325 AQEAHEAIRPTD---MGLQRPNVERDQARLYELIRMRTLASQMSDAQLERTQVKIRNDRD 381 Query: 419 DFRLKARGRILRFDGWTKVMPALRKGDE------DRILPAVNKGDALTLVELTPAQHFTK 472 D A G +++FDG+ KV L DE D +LPA+ +ALT +T Q FT+ Sbjct: 382 DRLFSANGEVIKFDGFLKVY--LEGKDEEDAEEQDGMLPAMQVDEALTNNYITATQRFTR 439 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR--------------------- 511 PP R++EASLVK+LE+ GIGRPSTYA ISTIQ+RGYV Sbjct: 440 PPYRYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEKGTVDGTEREYLQLTLEGGGV 499 Query: 512 ----------VENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWK 561 + + +G IV D L +F +++Y+FTA++E D +A E +W+ Sbjct: 500 KRKELSETVGSDKGKLVPTDIGMIVNDFLVSHFANILDYNFTAKVEKDFDDIATGEEDWQ 559 Query: 562 AVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG--VFLGC 619 VL F+ DF + D EE R + + D P GR++ +R G V +G Sbjct: 560 DVLRDFYKDFHPNV----LDVEENADRASGERVLGTD-PETGRQVAVRLGRFGPMVQIGT 614 Query: 620 SG-------YALPPKERCKT-----TINLVPENEVLNVLEGEDAETNALR 657 + +L P + T + L L EG++ E N R Sbjct: 615 ADEEEKPQFASLLPDQSLATITYDEAMELFKLPRKLGTFEGDEVEANVGR 664 >UniRef50_Q28MI5 DNA topoisomerase n=13 Tax=Rhodobacterales RepID=Q28MI5_JANSC Length = 907 Score = 439 bits (1128), Expect = e-121, Method: Compositional matrix adjust. Identities = 271/691 (39%), Positives = 377/691 (54%), Gaps = 109/691 (15%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +V+VESPAKAKTINKYLGSDY V +S GH+RDLP+ + Sbjct: 3 VVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPSKDGS--------------------- 41 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 VDP + +E+ +K V + + + + LATD DREGEAI+WHL+ Sbjct: 42 --------VDPEEGFFMKWEIGSDSKKHVKAIVDALKDDNSLILATDPDREGEAISWHLQ 93 Query: 125 EVIGG-----DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 E + D SRV FN ITK+A+ +A +P +++++ V A ARR +D +VG+ + Sbjct: 94 EALTSRKAIKTDTPVSRVTFNAITKDAVTKAMAEPRQVDMELVEAYLARRALDYLVGFNL 153 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP+LW+K+ SAGRVQSV +RLVVERE EI+AF P E+W V A TP G+ + ++T Sbjct: 154 SPVLWRKLPGAKSAGRVQSVCLRLVVEREMEIEAFRPREYWSVRAVLETPRGQTIEARLT 213 Query: 240 HQNDKP---FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 K + + + AV + + SV + E KP P PF+TSTLQQ AS + Sbjct: 214 VLGGKKLDRYDLPSAAEAGLAVQAVSSRKLSVSDVEAKPANRNPSPPFMTSTLQQEASRK 273 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 LG G K+ M AQRLYEAG+ITYMRTD +++ +AV RG I +G Y+P P Y Sbjct: 274 LGMGAKQAMSTAQRLYEAGHITYMRTDGIDMAPEAVEDARGAIKTRYGVDYVPGKPRIYK 333 Query: 357 SK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV 415 +K +N+QEAHE +RP+D++ A LK E D +KLY LIW++ +A QM A+ + TT+T+ Sbjct: 334 NKAKNAQEAHECVRPTDMSKAANDLKLSEDDQRKLYDLIWKRTIASQMEAARLERTTVTI 393 Query: 416 GAGD--FRLKARGRILRFDGWTKVMPALRK---GDED-RILPAVNKGDAL---------- 459 + D L+A G+++ FDG+ KV R DED + LP V+ GD L Sbjct: 394 ASDDREVELRATGQVMLFDGFLKVYEEGRDDAGDDEDSKRLPQVSAGDPLKPSADAMADD 453 Query: 460 -------TLVE--------------------LTPAQHFTKPPARFSEASLVKELEKRGIG 492 +VE + QH T PP R++EA+LVK +E+ GIG Sbjct: 454 YAKYSGDDVVEDDGNGDVRRSKSAILSREGAVLGQQHHTAPPPRYTEATLVKRMEELGIG 513 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 RPSTYASI+ TIQ+RGYV + R E G +VT L F + YDFTA +E LD+ Sbjct: 514 RPSTYASIMDTIQNRGYVIKDKGRLIPEDKGRLVTVFLSNYFNRYVQYDFTADLEQQLDE 573 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID-------------- 598 V+ + +K VLD F+ DF +D E +R + VL I+ Sbjct: 574 VSAGDRHYKDVLDRFWRDFRAAID------ETSDLRIGE-VLDKINEVLEPHLFPDPGDG 626 Query: 599 -----CPTCG-RKMGIRTA-STGVFLGCSGY 622 CP CG ++ +RTA + G F+GCS Y Sbjct: 627 TDPRLCPNCGVGRLSMRTARAGGAFIGCSAY 657 >UniRef50_B0VJB5 DNA topoisomerase n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VJB5_9BACT Length = 739 Score = 438 bits (1126), Expect = e-121, Method: Compositional matrix adjust. Identities = 266/710 (37%), Positives = 387/710 (54%), Gaps = 75/710 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKA TI+K+L + + VK+S+GHIRDLP Sbjct: 1 MSKGLIIVESPAKAGTISKFLKNQFSVKASMGHIRDLPK--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GV+ ++ Y + K KV++ELK+ AD +YLA+D DREGEAIA Sbjct: 40 --------RELGVNVHQGFKPVYIIDKTKSKVIAELKEATLSADSVYLASDNDREGEAIA 91 Query: 121 WHLREVIGG--DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 WHL E + ++ R+VFNEIT AI +A PG++++ +V AQQARR +DR+VGY Sbjct: 92 WHLSETLKKELNNKPVYRIVFNEITSQAINEAIKNPGQIDMAKVEAQQARRILDRLVGYE 151 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA---STTTPSGEALA 235 +SPLLWK I + LSAGRVQSVA+RL+ ERE EIKAFVP+E+W+++A P +A+ Sbjct: 152 ISPLLWKVITKDLSAGRVQSVALRLICEREAEIKAFVPKEYWKIEADFWKDNLPPFKAVL 211 Query: 236 LQVTHQNDKPFRPVNKEQTQAAVSLLE-----KARYSVLEREDKPTTSKPGAPFITSTLQ 290 ++ + V ++A+ ++E +A S ++R ++ +P PFITSTLQ Sbjct: 212 EKIEGKK------VEIPDEKSAIEIVENSQNAEAILSEIKRSNR--NVEPLPPFITSTLQ 263 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 Q AS LGF +KTM +AQ LYE G ITYMRTDST ++++A+ + I + Sbjct: 264 QEASKILGFQAQKTMSIAQVLYEGIDLGGERTGLITYMRTDSTRMAEEAITKAQNLIKER 323 Query: 343 FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 FGK+ + + +K+++Q+AHEAIRP+D ES+ + + KLY LIW++F+A Sbjct: 324 FGKELVHPKVRVFKNKQSAQDAHEAIRPTDPFRTPESVAQYLTKEQMKLYTLIWQRFIAT 383 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTL 461 QM P K ST++ + AG + G + +G+ K P L ++I K D L Sbjct: 384 QMIPVKLLSTSVKINAGKAEFVSSGAQIMEEGFLKAYPHLYIPLGEKIHQDYAKNDVLEH 443 Query: 462 VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521 L QHFT PAR++EASL+KELE +GIGRPSTYA+II T++ R YV +E + F + Sbjct: 444 SPLEKTQHFTTSPARYTEASLIKELEAKGIGRPSTYATIIETLRKRKYVTMEKKAFLPTQ 503 Query: 522 MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 +G V L + F L N FTA+ME LD+V W V+ ++ + + + Sbjct: 504 LGSDVNRFLVDKFDYLFNVQFTAEMETKLDEVEYSNIAWNEVVQEYYDQLVALIRQVDVK 563 Query: 582 PEEGGMRPNQMVLTSIDCPTCGR-KMGIRTASTGVFLGCSGYALPPKERCKTTINLV-PE 639 E+ + T I C C + M I+ + G FL CS + +CK T N E Sbjct: 564 KEKNNFVQD----TGIVCDVCKQGTMLIKHSKRGDFLSCSRFP-----QCKNTKNFTRDE 614 Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 + + + N CP+CG+ + + C N P C Sbjct: 615 DGNIKIFVPTPLNEN-------CPQCGSPL-MLRTGKYGEFIACSNYPKC 656 >UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria RepID=TOP1_XYLFT Length = 815 Score = 438 bits (1126), Expect = e-121, Method: Compositional matrix adjust. Identities = 258/646 (39%), Positives = 377/646 (58%), Gaps = 69/646 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDL-PTSGSAAKKSADSTSTKTAKKP 59 M K L+IVESPAKAKTINKYLG D+ V +S GH+RDL P G+ Sbjct: 1 MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGA----------------- 43 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 VDP + + Y+++ EK V + + A+ AD IYLATD DREGEAI Sbjct: 44 -------------VDPENGFAMRYDLIDKNEKHVEAITKAAKTADSIYLATDPDREGEAI 90 Query: 120 AWHLREVIGG----DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 +WH+ E++ D R+VF EIT AI++A KP + D V+AQQARR +D +V Sbjct: 91 SWHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRMIASDLVDAQQARRALDYLV 150 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE--A 233 G+ +SP+LW+K+ RGLSAGRVQS A+R++VERE EI+AF+ E+W + A T P+ A Sbjct: 151 GFNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFITREYWSIHAECTHPAQHFSA 210 Query: 234 LALQVTHQNDKPFRPVNKEQTQAAVSLLEKA---RYSVLEREDKPTTSKPGAPFITSTLQ 290 +++ + + F + + AA +++A R + + +K +P PFITSTLQ Sbjct: 211 KLIKLDGKKFEQFTITDSDTAAAAQRRIQQAAQGRLHITDVTNKERKRRPAPPFITSTLQ 270 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISD 341 Q AS +LGF +KTM +AQ+LYE G ITYMRTDS NLS DA++ +R I+ Sbjct: 271 QEASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLITYMRTDSVNLSLDALSEIRDIIAR 330 Query: 342 NFGKKYLPESPNQYASK-ENSQEAHEAIRP-SDVNVMAESLKDMEADAQKLYQLIWRQFV 399 ++G LP+ PN Y +K +N+QEAHEA+RP S + + + + +LY+L+W++ V Sbjct: 331 DYGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRTPTQVAPYLSNEEHRLYELVWKRTV 390 Query: 400 ACQMTPAKYDSTTLTVGAGDFRL-KARGRILRFDGWTKVMPALRKG------DEDRILPA 452 A QM PA ++T++ + AG+ + +A G + G+ V + DE R LP Sbjct: 391 ASQMIPAILNTTSVDLAAGNEHVFRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGRKLPV 450 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 + G+ + L + QHFT+PP R++EA+LVK LE+ GIGRPSTYASII T+ R YV + Sbjct: 451 MKTGENVPLERILTEQHFTQPPPRYTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVDM 510 Query: 513 ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 E R F +G V+ L +F + ++YDFTA +E+ LD ++ E EW ++ F+ F Sbjct: 511 EGRSFRPTDIGRAVSKFLSSHFTQYVDYDFTAHLEDELDAISRGEEEWIPLMKKFWVPF- 569 Query: 573 QQLDKAEKDP----EEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG 614 ++L + +KD + G +R L ID PT G+++ R G Sbjct: 570 KELVEDKKDSLDKTDAGSVR-----LLGID-PTSGKEVSARIGRFG 609 >UniRef50_C6V581 DNA topoisomerase n=2 Tax=Neorickettsia RepID=C6V581_NEORI Length = 827 Score = 436 bits (1121), Expect = e-120, Method: Compositional matrix adjust. Identities = 253/665 (38%), Positives = 382/665 (57%), Gaps = 68/665 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 ++IVESP K K I +YLG D+ V SS GH+R LP +++ Sbjct: 3 VLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALP-----------------------NKK 39 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 G+ VD ++E Y++ E VV +L + + A +YLATD DREGEAI+WHL Sbjct: 40 GS------VDVTDSFEMLYKLTDTGETVVPQLIKDVKNATALYLATDPDREGEAISWHLV 93 Query: 125 EVIGGDDA---RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 EV +D RVVF+EITK A++ A P +++ + V AQ+ R+ +D +VG+ +SP Sbjct: 94 EVFKENDVLPKNVHRVVFHEITKTAVQNAIASPRKIDENLVRAQRLRQALDYLVGFSISP 153 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 +LWKK+ SAGRVQSVA+R++ +RE EI F PEE+W V + T G + Q++H Sbjct: 154 VLWKKLPGSKSAGRVQSVALRILCDRENEIGLFTPEEYWIVSVNMTDGEGLVIPTQLSHI 213 Query: 242 NDKPFRPVNKEQTQAAVSLLEKAR---YSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 N + ++ + A ++E+ R + V E + K KP PFITST+QQ AST LG Sbjct: 214 NGEKLERMSIRGAEEAEKIVEEIRELPFLVEEIKKKELKQKPSPPFITSTMQQTASTVLG 273 Query: 299 FGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 F VKKTM +AQ+LYE G ITYMRTD+T+LS ++V+ +R +I FG++YLPE Sbjct: 274 FSVKKTMSLAQKLYEGIEIGGAIEGLITYMRTDATHLSVESVDAIREFIQKKFGQEYLPE 333 Query: 351 SPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKY 408 SP + K +N+QEAHEAIRP+ + E ++ + D KLY+LIW + +ACQM+ A Sbjct: 334 SPVLFKKKVKNAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWERALACQMSDAIT 393 Query: 409 DSTTLTVGAGD--FRLKARGRILRFDGWTKVMPALRKGDEDR-ILPAVNK---GDALTLV 462 S + + D F+ A +L FDG+ + ++++ ++ + K G + + Sbjct: 394 SSQNIVFISQDEKFKTSASASLLIFDGFNAAFSHGKNKNKNQGVIDFIKKHKEGAQVKVG 453 Query: 463 ELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKM 522 ++ P Q+FT+PP R+SEA LVK LE+ GIGRPSTYA+++S +Q+RGY + N+ F E Sbjct: 454 DVLPTQNFTEPPHRYSEAGLVKHLEELGIGRPSTYATVVSVLQERGYASIVNKSFIPENR 513 Query: 523 GEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDP 582 G +V++ L F + + Y FTA+ME+ LD+VA+ W V+ F+ F +++ EK P Sbjct: 514 GRLVSEFLVHFFSKYVEYHFTAEMEDRLDKVADGTIFWLDVIQDFWDSFHSNVEEVEKVP 573 Query: 583 -------EEGGMRPNQMVLTSI----DCPTCGR-KMGIRTASTGVFLGCSGYALPPKERC 630 G + ++V + CP C + M + + GVFLGC+ Y + C Sbjct: 574 ITEVLAFVNGALAKQKLVSAEVKVGDKCPKCEKGYMHLSVSRYGVFLGCTNYPV-----C 628 Query: 631 KTTIN 635 + +N Sbjct: 629 RFIVN 633 >UniRef50_A8EWX5 DNA topoisomerase I n=2 Tax=Campylobacterales RepID=A8EWX5_ARCB4 Length = 756 Score = 435 bits (1119), Expect = e-120, Method: Compositional matrix adjust. Identities = 246/612 (40%), Positives = 361/612 (58%), Gaps = 59/612 (9%) Query: 29 SSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPG 88 +S+GH+RDLP S +G DP N++ Y++ Sbjct: 2 ASMGHVRDLPKSS-----------------------------LGFDPNDNFKPKYQISTD 32 Query: 89 KEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIR 148 K+KV+++LK+ K IYLA D DREGEAIAWHL + + R+VF+EITK+AI Sbjct: 33 KKKVITDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAIL 92 Query: 149 QAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERE 208 +A P +++ + V+AQQARR +DR VGY +SPLLWKK+ GLSAGRVQSVAVR++V+RE Sbjct: 93 KALENPRDVDQNLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRE 152 Query: 209 REIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSV 268 EI+AFVPEE+W++ A P L ++ +N K + N++Q + L++ Y + Sbjct: 153 NEIRAFVPEEYWKIKADFINPE---LKAELAKENGKTLKISNEKQALEIEASLKQGSYKL 209 Query: 269 LEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE----------AGYIT 318 ++ E+K +T P APF TSTLQQ AS +LGF VK+TM++AQ+LYE G IT Sbjct: 210 VDIEEKESTRNPAAPFTTSTLQQEASRKLGFSVKQTMIIAQQLYEGNVGNIPNHTGGLIT 269 Query: 319 YMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMA 377 YMRTDS NLS A + I + +GK+Y P Y +K + +QEAHEAIRP ++ + Sbjct: 270 YMRTDSLNLSTVATTAAKAVIEEEYGKEYALNKPRVYTTKSKGAQEAHEAIRPVNLALRP 329 Query: 378 ESLKDMEADAQ-KLYQLIWRQFVACQMTPAKYDSTTLTVGAG---DFRLKARGRILRFDG 433 +K+ AQ +LY LIW++ +A QM AK +TT + AG +F + +G+ + F G Sbjct: 330 SQIKEFVEPAQYRLYSLIWKRTLATQMAQAKIANTTYKIEAGKNKEFEFQVKGQRIIFAG 389 Query: 434 WTKVM------PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE 487 + K P ++ILP + +G L L +L Q+FTKPPAR++EASLVK+LE Sbjct: 390 FMKAYTEGSDNPEAALDSSEKILPNIKEGTILELEKLESEQNFTKPPARYTEASLVKKLE 449 Query: 488 KRGIGRPSTYASIISTIQDRGYV-RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546 GIGRPSTYA ISTIQ R YV + E+ + + GEIV L ++F +++ FTA++ Sbjct: 450 SEGIGRPSTYAPTISTIQAREYVSKTEDNKLIPTQTGEIVNSFLVDHFSNIVDLGFTAKI 509 Query: 547 ENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD-PEEGGMRPNQMVLTSIDCPTCGRK 605 E D++A + W+ V+ +F+ F + +D+ E +E ++ N++ ID P G+ Sbjct: 510 EEEFDEIAEGKIAWEEVMKNFYGGFKKTIDEKESSVSKEDYLQVNEL---GID-PKSGKP 565 Query: 606 MGIRTASTGVFL 617 + R G F+ Sbjct: 566 VSARVGRFGPFV 577 >UniRef50_Q47L55 DNA topoisomerase n=4 Tax=Actinomycetales RepID=Q47L55_THEFY Length = 906 Score = 433 bits (1113), Expect = e-119, Method: Compositional matrix adjust. Identities = 290/704 (41%), Positives = 384/704 (54%), Gaps = 67/704 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK- 60 G LVIVESPAKAKTI YLG Y+V+SS+GHIRDLP K A+ P Sbjct: 20 GNKLVIVESPAKAKTIAGYLGPGYIVESSIGHIRDLPN--------------KAAEIPAR 65 Query: 61 -KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 KDE A R+GV+ ++E Y V K+ V LK+L +AD +YLATD DREGEAI Sbjct: 66 YKDEPWA---RLGVNVDRDFEPLYVVNADKKAQVKRLKELLAEADELYLATDEDREGEAI 122 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 AWHLRE + R+VFNEITK AIR A +LN+ V+AQ+ RR +DR+ GY V Sbjct: 123 AWHLREELK-PTIPVKRMVFNEITKEAIRHAAQHTRDLNLRLVDAQETRRILDRLYGYEV 181 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA------------STT 227 SP+LWKK+ LSAGRVQSVA RLVVERERE AF P E+W + A TT Sbjct: 182 SPVLWKKVMPSLSAGRVQSVATRLVVERERERIAFTPAEYWGLKAVFAVLTGTDGADPTT 241 Query: 228 TPS------------GEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 P+ G Q ++ K R +++E + L A+Y+V E KP Sbjct: 242 FPATLATVDGDRVAQGRDFTSQGVLRSPKGVRHLDEETARGLAERLAGAQYTVRSVERKP 301 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMV 335 P APF T+TLQQ AS +LG K+TM +AQRLYE GYITYMRTDST LS+ A+ Sbjct: 302 YRRSPYAPFRTTTLQQEASRKLGLSAKQTMQVAQRLYENGYITYMRTDSTTLSESAIAAA 361 Query: 336 RGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 R ++ +G YLP+ P Y SK +N+QEAHEAIRP+ + + +LY+LI Sbjct: 362 RAQVARLYGDNYLPDKPRTYTSKVKNAQEAHEAIRPAGDTFRTPAETGLSGVELRLYELI 421 Query: 395 WRQFVACQMTPAKYDSTTLTVG----AGD-FRLKARGRILRFDGWTKVM------PALRK 443 W++ +A QM A +S ++ V AG+ A G+I+ F G+ K P Sbjct: 422 WKRTIASQMKDAVGESVSVRVAGTSTAGEQVEFSATGKIITFHGFLKAYVEGTDDPQAEL 481 Query: 444 GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 503 D +R LP + +GD L + H T+PPAR++EASLVKELE+R IGRPSTYA+II T Sbjct: 482 DDRERRLPPLTEGDPLHAQSVDAEGHSTRPPARYTEASLVKELEEREIGRPSTYATIIGT 541 Query: 504 IQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 I +RGYV + + V LE +F L++YDFTA+ME+ LD +A EAE Sbjct: 542 ILERGYVFKKGSALVPSFLAFAVVQLLERHFSHLVDYDFTARMEDVLDAIARGEAERVPW 601 Query: 564 LDHFFSDFTQQLDKAEKDPEE-GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGY 622 L F+ Q+ E E G + P + ++S P + +R G +L +G Sbjct: 602 LRRFYFGADGQIGLKELVNEHLGDIDPKE--ISSFPLPDS--DIVLRVGRYGPYLERNG- 656 Query: 623 ALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 +R +L P+ E A+ N R + P+ G Sbjct: 657 -----QRVNVPDDLAPDELTKERAEELFAQPNGDRELGKDPETG 695 >UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms RepID=TOP1_ZYMMO Length = 1217 Score = 432 bits (1112), Expect = e-119, Method: Compositional matrix adjust. Identities = 262/657 (39%), Positives = 368/657 (56%), Gaps = 82/657 (12%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LV+VESPAKAKTI KYLGS Y V +S GHIRDLP+ + Sbjct: 8 LVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDGS--------------------- 46 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 V+P + + ++ P K + ++ +++D + LATD DREGEAI+WH+ Sbjct: 47 --------VNPDNGFSMVWQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHIL 98 Query: 125 EVIGG-----DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 E++ DD RV FN ITK A+ A P +L+ D +NA ARR +D +VG+ + Sbjct: 99 ELLKTKKLLPDDVE--RVTFNAITKAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTL 156 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS--GEALALQ 237 SP+LW+K+ SAGRVQSVA+RLVV+RE+EI+ F P+E+W V+A S + +Q Sbjct: 157 SPILWRKLPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQ 216 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 Q + +K Q +AA S +E ++V E KP + P PF TSTLQQ A+ +L Sbjct: 217 WRGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKL 276 Query: 298 GFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYAS 357 GF TM +AQ LYE G ITYMRTD + + A+ R I+ + Y+P+ P QY Sbjct: 277 GFAASHTMRLAQSLYEEGLITYMRTDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQV 336 Query: 358 K-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT--LT 414 K +N+QEAHEAIRP+D + K D +LY+LIW++ +A QM AK + TT LT Sbjct: 337 KAKNAQEAHEAIRPTDFS----RDKAASGDHARLYELIWKRALASQMASAKLERTTVDLT 392 Query: 415 VGAGDFRLKARGRILRFDGWTKVMPAL-------RKGDEDRI-LPAVNKGDALTLVELTP 466 G G L+ G+++ F G+ + R G E R LP + GDA E+ Sbjct: 393 DGTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRA 452 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 QHFT+PP R+SEASLVK++E GIGRPSTYAS+I ++DR YV +E RF + G ++ Sbjct: 453 DQHFTQPPPRYSEASLVKKMEDLGIGRPSTYASVIQVLKDRAYVTLERNRFIPSEAGRLL 512 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF--------------- 571 T LE F ++YDFTA +E+SLD+++ A+W+ VLD F+ DF Sbjct: 513 TAFLERFFERYVSYDFTAGLEDSLDEISGGRADWQKVLDAFWHDFKPKTAEVMEQQPSAI 572 Query: 572 TQQLDKAEKD---PEEG-GMRPNQMVLTSIDCPTC--GRKMGIRTASTGVFLGCSGY 622 T +LDK + P++G G P + CP+C GR + ++ G F+ CS Y Sbjct: 573 TAELDKFLEPWLFPDKGDGHDPRE-------CPSCHTGR-LALKGGRFGAFIACSNY 621 >UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus RepID=Q5SM69_THET8 Length = 830 Score = 430 bits (1106), Expect = e-118, Method: Compositional matrix adjust. Identities = 284/760 (37%), Positives = 396/760 (52%), Gaps = 104/760 (13%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LV+VESPAKA++I K LG Y V++S+GH+ DLP ER Sbjct: 18 LVVVESPAKARSIQKMLGPGYEVRASLGHVVDLP------------------------ER 53 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +GVD ++ YEV K+ VV ELK+ AE + +ATD DREGEAI WH+ Sbjct: 54 S-----LGVDVERDFAPTYEVKKDKKPVVEELKRAAE-GKRLLIATDPDREGEAIGWHVA 107 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 ++G D RV F+EIT +RQA P ++ + V+AQQARR +DR++GY +SPLL Sbjct: 108 RLLGRDPKEPLRVEFHEITPRVVRQAVEAPRPIDQNLVDAQQARRVLDRLLGYNLSPLLS 167 Query: 185 KKI-ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 + R LSAGRVQSVA+RLVVERE I+AF PEE+W + GEA + H+ + Sbjct: 168 LEFRKRALSAGRVQSVALRLVVEREEAIEAFRPEEYWVLRGVFAVEGGEAPLVATLHEVE 227 Query: 244 KPFRPVNKEQTQAAVSLL------------EKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + + + + L K Y V + E + P PF TSTLQQ Sbjct: 228 GKRLWTGQGEKEGRLHLASEAEAHALAEALRKGSYRVAQVEVRERRKAPPPPFTTSTLQQ 287 Query: 292 AASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNF 343 AAS+RLG+ +TM +AQRLYE G ITYMRTDS ++ +AV R I F Sbjct: 288 AASSRLGYTAARTMRIAQRLYEGVDLPEGTVGLITYMRTDSVRVAPEAVAAAREVIGKAF 347 Query: 344 GKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 G +YLPE+P Y ++ E Q+AHEAIRP+D ES++ + + +LY+LIWR+F+A Sbjct: 348 GPEYLPEAPRAYKNRREGVQDAHEAIRPTDPKRTPESVRPYLSEEEYRLYELIWRRFLAS 407 Query: 402 QMTPAKYDSTTLTVG--AGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 QM A Y+ T +T+ G + +A G +LRF+G+ + + +E+ +PAV +G Sbjct: 408 QMRDALYEQTAVTLADLEGRYAFRASGSVLRFEGYLRAWGRDAEEEEEPPVPAVPEGVPA 467 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 L E+ + FT+PP R+++ASLVK +E+ GIGRPSTYA + T++ RGYV + R + Sbjct: 468 RLEEVLEERRFTEPPPRYTDASLVKTMEELGIGRPSTYAPTLETLEKRGYVARKGRTLFP 527 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 +G VT L E F +++ Y+FTA+ME LD+V W V+ F+ F +L + Sbjct: 528 TPLGRQVTAYLRERFPQVVAYEFTARMEERLDEVEEGRVPWPKVVWEFYEPFLGELAQVP 587 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPE 639 K CP CGR + ++ + G FLGC+GY PE Sbjct: 588 KK----------------TCPRCGRPLELKVSRYGQFLGCTGY---------------PE 616 Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR--KLHVCGNNPTCDGYEIEEG 697 LE +AE CPKCG + L R C P CD Y ++G Sbjct: 617 CTYTEPLERREAEPIG----EACPKCGRPL---LRKEGRYGTFIACSGYPECD-YTRDDG 668 Query: 698 EFRIKGYDGPIVECEKCGSEMHLKMGRFGK-YMACTNEEC 736 G+ C KCG + K R G+ Y C N C Sbjct: 669 T--PTGHT-----CPKCGGRVLEKRSRKGRPYYKCENNAC 701 Score = 43.9 bits (102), Expect = 0.027, Method: Compositional matrix adjust. Identities = 25/84 (29%), Positives = 40/84 (47%), Gaps = 10/84 (11%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C +CG + LK+ R+G+++ CT EC T + R E P E C K Sbjct: 591 CPRCGRPLELKVSRYGQFLGCTGYPECTYTEPLERR-EAEPIGEA--------CPKCGRP 641 Query: 770 FVLRDGAAGVFLAANTFPKSRETR 793 + ++G G F+A + +P+ TR Sbjct: 642 LLRKEGRYGTFIACSGYPECDYTR 665 >UniRef50_O69548 DNA topoisomerase 1 n=28 Tax=Actinomycetales RepID=TOP1_MYCLE Length = 947 Score = 430 bits (1105), Expect = e-118, Method: Compositional matrix adjust. Identities = 275/700 (39%), Positives = 386/700 (55%), Gaps = 77/700 (11%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP KA+ ++ YLGS Y+V+SS GHIRDLP ++A K +P Sbjct: 18 LVIVESPTKARKLSGYLGSAYIVESSRGHIRDLP-------RTAADVPAKFKSEPWA--- 67 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 R+GV+ ++E Y + P K+ V+ELK L + D +YLATD DREGEAIAWHL Sbjct: 68 -----RLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWHLM 122 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 + + R+VF+EIT++AI A P EL+ID V+AQ+ RR +DR+ GY VSP+LW Sbjct: 123 QTLK-PRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVLW 181 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV----DASTTTPSGEAL------ 234 KK+A LSAGRVQSVA R++V+RER+ AF +W++ DAS + P+ + L Sbjct: 182 KKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVARL 241 Query: 235 ----ALQV----------THQNDKPFRPVNKEQTQAAVSL---LEKARYSVLEREDKPTT 277 L+V T + D + A +L L A+ +V E+K T Sbjct: 242 TAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLYT 301 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 +P PF+TSTLQQ A +L F ++TM +AQRLYE GYITYMRTDST LS+ A+N R Sbjct: 302 RRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAART 361 Query: 338 YISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLYQLI 394 +G++Y+ +SP QY K +N+QEAHEAIRP+ +++ D ++Y+L+ Sbjct: 362 QARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIYELV 421 Query: 395 WRQFVACQMTPAKYDSTTLTV----GAGDFRLKARGRILRFDGWTKV-------MPALRK 443 WR+ VA QM A+ + +L + G A GR L F G+ K + Sbjct: 422 WRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGEA 481 Query: 444 GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 503 D +R LP + G L +++LTP H T PPAR++EASLVK LE+ GIGRPSTY+SII T Sbjct: 482 DDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIKT 541 Query: 504 IQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 +QDRGYV+ + + VT LE++F L++YDFTA ME+ LD++AN + Sbjct: 542 VQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTNW 601 Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMV-LTSIDCPTC----------GRKMGIRTAS 612 L++F+ F ++ GG++ V + ID GR + +R Sbjct: 602 LNNFY--FGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGK 659 Query: 613 TGVFL-----GCSGYALPPKERCKTTINLVPENEVLNVLE 647 TG +L G G P +R L P+ L V E Sbjct: 660 TGPYLERLLAGDDGELTP--QRANLNGTLTPDELTLEVAE 697 >UniRef50_C1D174 DNA topoisomerase n=34 Tax=cellular organisms RepID=C1D174_DEIDV Length = 966 Score = 427 bits (1098), Expect = e-118, Method: Compositional matrix adjust. Identities = 259/601 (43%), Positives = 351/601 (58%), Gaps = 49/601 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESPAKA+TI KYLG Y V+SS+GHIRDLP S S P+ Sbjct: 1 MARTLVIVESPAKARTIEKYLGKGYAVESSIGHIRDLPKSAS--------------DIPE 46 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 K +G R+G+D ++++ Y V P K + V++L++LA AD I LATD DREGE+IA Sbjct: 47 K-YKGKAWARLGLDIENDFQPLYVVAPDKRQHVAKLRKLAADADEIILATDDDREGESIA 105 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL + + R+VF+EITK AI+ A P +++ + V AQ+ARR +DR+ GY VS Sbjct: 106 WHLFQELK-PKVPVKRMVFHEITKEAIQAAIAHPRQIDTNLVEAQEARRALDRLYGYEVS 164 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+A LSAGRVQSVA R++VERERE FV +W++ + T G+ ++T Sbjct: 165 PVLWKKVAPKLSAGRVQSVATRMLVERERERMRFVSATWWDLLVTGKTGDGQTFPARLTD 224 Query: 241 QND------KPFRPV-NKEQTQAAVSLLEKAR------------YSVLEREDKPTTSKPG 281 K F P+ + + AAV LL +A +V E+KP T +P Sbjct: 225 VGGQRLAAGKDFDPLTGRLKEGAAVRLLTEAEAQALTAGLTGQALTVTSAEEKPFTQRPY 284 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 APFITSTLQQ S +LGF +TM AQ+LYE GYITYMRTDSTNLS +AV R ++ Sbjct: 285 APFITSTLQQEGSRKLGFAATRTMRAAQKLYEGGYITYMRTDSTNLSVEAVTAARTQVTQ 344 Query: 342 NFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNV-MAESLK-DMEADAQKLYQLIWRQF 398 +G +L P YA K +N+QEAHEAIRP+ + +SL+ ++ D +LY LIW++ Sbjct: 345 MYGPAFLHPQPRVYAKKAKNAQEAHEAIRPAGSSFRTPDSLRGELGGDEWRLYDLIWKRT 404 Query: 399 VACQMTPAKYDSTTLTVGAG-----DFRLKARGRILRFDGWTKVM------PALRKGDED 447 VA QM A+ S + +G L A GR + F G+ + P D D Sbjct: 405 VASQMADARGRSLRVRLGGQAQGGETVGLSASGRTIDFPGFLRAYVEGSDDPNAALEDRD 464 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 LP + +G +T + P H T+PPAR++EASLV+ LE GIGRPSTYASI+ TIQDR Sbjct: 465 TPLPPLKEGQQVTAETVRPESHETQPPARYTEASLVQALEAAGIGRPSTYASILGTIQDR 524 Query: 508 GYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 GY + + + LE +F +L++YDFTA+ME LD +A A L F Sbjct: 525 GYATKKGQALVPTWTAFATSALLEHHFGKLVDYDFTARMEEDLDDIAGGRASRVPYLRRF 584 Query: 568 F 568 + Sbjct: 585 Y 585 >UniRef50_D0LEI6 DNA topoisomerase n=36 Tax=Actinomycetales RepID=D0LEI6_GORB4 Length = 1031 Score = 426 bits (1094), Expect = e-117, Method: Compositional matrix adjust. Identities = 267/618 (43%), Positives = 354/618 (57%), Gaps = 54/618 (8%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP KA+ I YLGS+YVV+SS GHIRDLP A P K + Sbjct: 18 LVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRGA--------------ADVPAK-YK 62 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 G R+GV+ N+E Y V P K+ V+ELK L D +YLATD DREGEAIAWHL Sbjct: 63 GQPWARLGVNVDENFEPLYVVSPDKKSTVTELKSLMRDVDELYLATDGDREGEAIAWHLL 122 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 E + R+VF+EIT+ AIR A P +L+ID V+AQ+ RR +DR+ GY VSP+LW Sbjct: 123 ETLK-PKIPVKRMVFHEITEPAIRAAAENPRDLDIDLVDAQETRRILDRLYGYEVSPVLW 181 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT---PSGEALALQVTHQ 241 KK+ LSAGRVQSVA R++VERERE AFV E+W++DA+ S + ++ Sbjct: 182 KKVMPKLSAGRVQSVATRIIVERERERMAFVSAEYWDIDANMDAGKDASPQTFNARLVGV 241 Query: 242 ND------KPFRP------------VNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 +D + F +++ + +A L+ A +V E+KP T +P AP Sbjct: 242 DDARVATGRDFDSRGALKRADGVVVLDETRARALADALDGADITVSSVEEKPYTRRPYAP 301 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNF 343 F+TSTLQQ A +L F +TM +AQRLYE G+ITYMRTDST LS+ A+N R + + Sbjct: 302 FMTSTLQQEAGRKLRFSSDRTMRIAQRLYENGFITYMRTDSTTLSESAINAARAQARELY 361 Query: 344 GKKYLPESPNQYASK-ENSQEAHEAIRPS--DVNVMAESLKDMEADAQKLYQLIWRQFVA 400 G Y+ +P Q+ K +N+QEAHEAIRP+ + +EAD +LY+LIW++ VA Sbjct: 362 GDNYVHPTPRQHTRKVKNAQEAHEAIRPAGESFRTPGQVAGQLEADEFRLYELIWQRTVA 421 Query: 401 CQMTPAKYDSTTL----TVGAGDF-RLKARGRILRFDG----WTKVMPALRKG---DEDR 448 QM AK + +L T G+ A GR + F G + + + L G D + Sbjct: 422 SQMADAKGTTLSLRMTGTASTGETCVFAASGRTITFPGFLSAYVETVDDLAGGQADDAEN 481 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508 LP + +G AL EL+ H T PPARF+EASLVK LE+ GIGRPSTYASII TIQDRG Sbjct: 482 RLPQLREGQALRATELSADGHSTNPPARFTEASLVKVLEELGIGRPSTYASIIGTIQDRG 541 Query: 509 YVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 YV + + V LE F+ L++YDFTA +E+ LD++A+ L F+ Sbjct: 542 YVVKKGNALVPSWIAFAVVGLLEAYFQGLVDYDFTASLEDDLDEIASGRENRTRWLTEFY 601 Query: 569 SDFTQQLDKAEKDPEEGG 586 F AE D E G Sbjct: 602 --FGDAAPNAEHDAEIAG 617 >UniRef50_C7MGF4 DNA topoisomerase n=5 Tax=Actinobacteridae RepID=C7MGF4_BRAFD Length = 904 Score = 424 bits (1091), Expect = e-117, Method: Compositional matrix adjust. Identities = 257/613 (41%), Positives = 351/613 (57%), Gaps = 60/613 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ LVIVESPAKA+TI +YLG +Y VK+SVGHIRD+P P + Sbjct: 4 GRHLVIVESPAKARTIGRYLGEEYDVKASVGHIRDIPVPRDL---------------PAE 48 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++G + GVD + ++ +Y V P K+K V+ELK+ + AD +YLATD DREGEAIAW Sbjct: 49 MKKGPY-GKFGVDVENGFDPYYIVSPDKKKTVAELKKALKDADTLYLATDEDREGEAIAW 107 Query: 122 HLREVIGGDDAR-YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 HL E + + R+VF+EITK+AIR A +++ V+AQ+ RR +DR+VG+ +S Sbjct: 108 HLLETLKPKKSLPVKRMVFHEITKDAIRAALENTRDIDASLVDAQETRRILDRLVGFELS 167 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV---------------DAS 225 P+LW+KI LSAGRVQSVA RLVVERERE AFV ++W++ A Sbjct: 168 PVLWRKIKPSLSAGRVQSVATRLVVERERERMAFVAADYWDITGTFAAEGGADGTQFTAK 227 Query: 226 TTTPSGEALALQVTHQNDKPFRP-------VNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 T G +A +D +P + E TQ V +L A +V E KP T Sbjct: 228 IATVDGARVATGSDFADDGTLKPRAKNAAVLTAESTQTLVEVLGDAPATVTALESKPYTR 287 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY 338 +P APF TS+LQQ AS +L G ++ M +AQ LYE GYITYMRTDS LS +A+ R Sbjct: 288 RPAAPFTTSSLQQEASRKLRLGARQAMRVAQSLYENGYITYMRTDSVTLSGEAIRASRAQ 347 Query: 339 ISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPS--DVNVMAESLKDMEADAQKLYQLIW 395 ++ +G +++P+ P Y +K + +QEAHEAIRP+ AE + D +LY+LIW Sbjct: 348 AAELYGSQFVPDKPRYYQNKSQAAQEAHEAIRPAGDHFRTPAEVAGQLSGDEFRLYELIW 407 Query: 396 RQFVACQMTPAKYDSTTLTV------GAGDFRLKARGRILRFDGWTKVMPALR-----KG 444 ++ +A QM AK ++T+ + A FR A G ++ F G+ R K Sbjct: 408 KRTIASQMADAKGTTSTVELLLENEGRAATFR--AAGTVITFRGFLAAYEEGRDASRYKD 465 Query: 445 DE----DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASI 500 DE D+ LP + +G L LTP H T PP R++EASLV+ LE RGIGRPSTYAS Sbjct: 466 DEEKGGDKRLPQMEEGQTLDTRALTPDGHTTTPPPRYTEASLVRALEDRGIGRPSTYAST 525 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 ++T+QDRGYV V LEE+F ++YDFTAQME LD++A + Sbjct: 526 VATVQDRGYVLRRGTALVPSWTAFAVVRLLEEHFGPFIDYDFTAQMEQQLDRMAQGDLAR 585 Query: 561 KAVLDHFF-SDFT 572 L +F+ SD T Sbjct: 586 SEYLKNFYLSDGT 598 >UniRef50_D1N8U4 DNA topoisomerase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N8U4_9BACT Length = 841 Score = 424 bits (1090), Expect = e-117, Method: Compositional matrix adjust. Identities = 265/639 (41%), Positives = 355/639 (55%), Gaps = 59/639 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+IVESP KA+TI K LG DY + +S+GHIRDLP ER Sbjct: 4 LLIVESPTKARTIGKMLGKDYDIFASMGHIRDLP------------------------ER 39 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +GVD +++ Y + VV ELK A+KAD IYLA D DREGEAIAWHL Sbjct: 40 D-----LGVDIANHFAPQYVDTARSKSVVKELKSAAKKADEIYLAPDPDREGEAIAWHLA 94 Query: 125 EVIG-GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 EV+ A + RV F+EIT++AI +A + GE+N++ V+AQQARR +DR+VGY VSPLL Sbjct: 95 EVLNKSTKAPFYRVTFHEITRSAIERAMQEKGEINLNLVDAQQARRVLDRIVGYQVSPLL 154 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 W +I +G SAGRVQS A+RLVVERER I AFVPEE+W T SGE ++ N Sbjct: 155 WSRIEKGSSAGRVQSAALRLVVERERAINAFVPEEYWVFSVVFRTESGEEFTSRLFKING 214 Query: 244 KPFRPVNKEQTQAAVSLLEK----ARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 K F+ N E + + ++ A SV E K APF TSTLQQAA+ L + Sbjct: 215 KDFKVPNAEAAEQLIRAIQGGSAPAVASVTTAERKRYAQ---APFTTSTLQQAANVSLHY 271 Query: 300 GVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 TM AQ+LYE G ITYMRTDS ++++A +I +G Y+P Sbjct: 272 SATNTMRYAQQLYEGMDIGEGGAVGLITYMRTDSVTIAREAQQAAAEFIRRTYGDAYVPA 331 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 N Y +K +QEAHEAIRP+DV E + ++ KLY LIWR+FVA QMTPA + Sbjct: 332 KFNYYKNKAAAQEAHEAIRPTDVRRTPEQMAAYLDPQQLKLYTLIWRRFVASQMTPAVVN 391 Query: 410 STTLTVG-----AGDFRLKARGRILRFDGWTKVMP--ALRKGD--EDRILPAVNKGDALT 460 TT+ VG + + + F G +KV A RK + E +L ++ + D L Sbjct: 392 LTTVDVGVDGSDGNGYTFRTTATVPVFPGHSKVYEDVAKRKDETQEAAVLGSLRERDPLE 451 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 L + Q FT+PP R++EASL+KELE+ GIGRPSTYA+I+ TIQDR YV E + Sbjct: 452 LRKFDKEQKFTEPPPRYTEASLIKELEENGIGRPSTYATILRTIQDRNYVNREQGKLIPS 511 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK 580 ++G V D L E L + FTAQME LD++ + W +++ F+S F ++ A+ Sbjct: 512 ELGFSVNDFLVERLPALFDIGFTAQMEKELDEIEEGKVGWTQMMEDFYSKFAPWVEDAKN 571 Query: 581 DPEEGGMRPNQM--VLTSIDCPTCGRKMGIRTASTGVFL 617 + +L ++ G K+G RT G F Sbjct: 572 SDAPPAADAEALLKLLENVTFEAPG-KVGRRTYDDGKFF 609 >UniRef50_A9BI47 DNA topoisomerase n=3 Tax=Thermotogaceae RepID=A9BI47_PETMO Length = 762 Score = 424 bits (1089), Expect = e-116, Method: Compositional matrix adjust. Identities = 273/792 (34%), Positives = 414/792 (52%), Gaps = 122/792 (15%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K +VIVESP+KAKTI +YLG +Y V +S GHIRDLP Sbjct: 15 SKYVVIVESPSKAKTIERYLGKEYKVIASKGHIRDLPKK--------------------- 53 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 GVD H++E ++V+PGKEKV+ E+K+ K + LA+D+DREGEAIAW Sbjct: 54 --------EFGVDIEHDFEPIFQVIPGKEKVIQEIKK-ETKGRKVLLASDMDREGEAIAW 104 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL +++ D +R++F+EITKNAI+ + + P L++ +V+AQ ARR +DR+VGY +SP Sbjct: 105 HLSQILDLDPKEKNRIIFSEITKNAIKNSISNPQSLDLKKVDAQIARRILDRLVGYKISP 164 Query: 182 LLWKKIA-RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 L+WK + SAGRVQS A++L+V++ER+I F P++++ + G+ + L T Sbjct: 165 LVWKVLKDYKTSAGRVQSAALKLIVDKERKIFIFKPKKYFNIYLEY---KGQNIPL--TK 219 Query: 241 QNDKPFRP--VNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 ++ K +P + K + L+ + ++ E+K + KP PFITSTLQQAA + Sbjct: 220 EDGKKIKPESITKIKKDQIFEYLKDKDFKLVNVEEKESIRKPPLPFITSTLQQAAVSTFN 279 Query: 299 FGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 + K M +AQ LYE +ITYMRTDST +S +A Y+ N+GK Y+ Sbjct: 280 WASSKVMKIAQELYEGVETSEGSIAFITYMRTDSTRVSNEAQQAAINYLEKNYGKDYV-- 337 Query: 351 SPNQYASKE---NSQEAHEAIRPSDVNVMAESLKDM-EADAQKLYQLIWRQFVACQMTPA 406 Y SK N Q+AHEAIRP+D+N+ + K + +D KLY LIW +F+A Q P+ Sbjct: 338 --GHYLSKNKKSNVQDAHEAIRPTDINMDVNNAKRLISSDHLKLYTLIWNRFMASQSAPS 395 Query: 407 KYDSTTLTV--GAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 464 +Y T T+ + + + FDG+ K K + + K D +T +L Sbjct: 396 RYLEKTYTIEDNTNKYAFEITSKKCIFDGFEKFWNPNNK----EVNFEIGKNDKITYDQL 451 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV-RVENRRFYAEKMG 523 + T PP R++EA+L+KELE +GIGRPSTYA+IIST+ R YV ++ G Sbjct: 452 KFEEKETNPPNRYTEATLIKELESKGIGRPSTYATIISTLLQRKYVSKIAKSTLRPTTTG 511 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPE 583 +VTD LE F E+++ FTA ME LD++ + + + K VL+ F+ +F L A Sbjct: 512 FVVTDFLETYFPEIVDVKFTANMEEDLDKIEDGKNKSKVVLEQFYKEFETFLSTA----- 566 Query: 584 EGGMRPNQMVL---TSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEN 640 ++ + +L + + C CG+ M + G++L C E CK T Sbjct: 567 SNNIKNKKEILHYESDVPCEKCGKNMKLNFGRYGLYLSC--------EECKET------- 611 Query: 641 EVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFR 700 ++ P +S+ + K KL++ E + + Sbjct: 612 -------------------QKIP-----AESFGVTIKEKLYI---------KEYLQETLK 638 Query: 701 IKGYDGPIVE-CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPL 758 I + I E C CG ++ LK G+FG+++AC+N ECK TR + G+ D V Sbjct: 639 IDKEENKIDEKCPICGGDLILKHGKFGEFIACSNYPECKYTRNVKARGKCPNCGGDIV-- 696 Query: 759 PELPCEKSDAYF 770 +L +K YF Sbjct: 697 -KLKSKKGKTYF 707 >UniRef50_D2QCS0 DNA topoisomerase I n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QCS0_9SPHI Length = 894 Score = 424 bits (1089), Expect = e-116, Method: Compositional matrix adjust. Identities = 254/649 (39%), Positives = 361/649 (55%), Gaps = 117/649 (18%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI YLG D+ VKSS GH+RDLP G Sbjct: 1 MSKNLVIVESPAKAKTIEGYLGKDFTVKSSFGHVRDLPKDG------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VD + + YE+ P K+K+VSELK LA+ A+ ++LATD DREGEAI+ Sbjct: 42 ----------LAVDVTNGFRPSYEISPDKKKLVSELKSLAKSAEEVWLATDDDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+E +G D R+VF EITKNAI A P +++D VNAQQARR +DR+VGY +S Sbjct: 92 WHLKEALGLRD-NTKRIVFREITKNAILNAIKSPRTIDVDLVNAQQARRVLDRLVGYELS 150 Query: 181 PLLWKKI---ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 P+LW+KI + GLSAGRVQSVA+RLVVEREREI + ++V A + L + Sbjct: 151 PVLWRKIKGGSTGLSAGRVQSVALRLVVEREREIDKHSAKSSFKVTAQFIVDGNKVLNAE 210 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEK---ARYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 + P N A + LE A +++ E +P P PF TSTLQQ +S Sbjct: 211 L---------PKNFATAAEARAFLEACVGATFTIKNLETRPAKKSPAPPFTTSTLQQESS 261 Query: 295 TRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 +L + V +TM +AQ LYEAG I+YMRTDSTNLSQ+A++ I FG+KY+ Q Sbjct: 262 RKLSYSVDRTMRIAQNLYEAGKISYMRTDSTNLSQEAIDKAVAEIGTEFGEKYI--QTRQ 319 Query: 355 YASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 + +K E++QEAHEAIRP++ N + + D ++LY+LIW++ +A QM A+ + TT+ Sbjct: 320 FKTKNESAQEAHEAIRPTNFN---DRSAGGDRDQKRLYELIWKRAIASQMADAQLERTTV 376 Query: 414 TVG-------AGDFR------------------------LKARGRILRFDGWTKVMPALR 442 T+G F+ L A+G +++FDG+ +V + Sbjct: 377 TIGIRFANGATTTFQTNVDDSPFVETPEAIAPNRSFPNELVAQGEVIKFDGFLRVYLESK 436 Query: 443 KGDEDR----ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYA 498 ++D +LP +N G L L ++ + FT+P R++EASLVK+LE+ GIGRPSTYA Sbjct: 437 DDEDDEDAKGMLPPLNIGQGLNLGQMKATEKFTRPQPRYAEASLVKKLEEMGIGRPSTYA 496 Query: 499 SIISTIQDRGYVRVENR-------------------------------RFYAEKMGEIVT 527 ISTI +RGYV +++ + + G +V Sbjct: 497 PTISTIVNRGYVTKQDKPGQERKYTEYTLQQNQISETSGKETYGSEKAKLFPTNTGIVVN 556 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 D L E F ++++Y FTA +E D++A+ W+ +L F+ DF + ++ Sbjct: 557 DFLVEYFPDIVDYKFTATVEKEFDEIADGRMNWQTMLQDFYGDFHKNIE 605 >UniRef50_B8DVL2 DNA topoisomerase n=14 Tax=Actinobacteridae RepID=B8DVL2_BIFA0 Length = 986 Score = 416 bits (1069), Expect = e-114, Method: Compositional matrix adjust. Identities = 292/777 (37%), Positives = 395/777 (50%), Gaps = 104/777 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LVIVESPAKAK I YLG Y V +SVGHIRDL + ++ P Sbjct: 4 GSKLVIVESPAKAKKIGGYLGDGYTVLASVGHIRDL---------------AQPSQVPA- 47 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 DE+ A + GVD ++ +Y V P K+K VSEL+ A +YLATD DREGEAIAW Sbjct: 48 DEK-AKFGKFGVDVNDGFKPYYIVGPEKKKTVSELRSALRNASELYLATDEDREGEAIAW 106 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL + + R+VF+EIT AIR + E++ + V+AQ+ RR +DR+ GY +SP Sbjct: 107 HLVQTLK-PKVPVKRMVFHEITPEAIRASLEHTREVDNNMVDAQETRRVLDRLYGYELSP 165 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS--GE------- 232 +LW+K+ GLSAGRVQSVA RL+VERERE AFV +W+V A+ P GE Sbjct: 166 VLWRKVGPGLSAGRVQSVATRLIVERERERMAFVRAPYWDVVATLCAPDALGEPTDFESR 225 Query: 233 ALALQVTH-QNDKPFRP----VNKEQTQAAVSL-----------LEKARYSVLEREDKPT 276 +AL T K F+ + +T V L L AR+ V+ E KP Sbjct: 226 MIALNGTRLATSKDFKSDGTLTDAARTDGVVQLGESQAGDLADALADARFRVISVEKKPY 285 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 +P PF TST+QQAA RLG ++TM AQ LYE GYITYMRTDS LS +A+ R Sbjct: 286 RRRPQPPFTTSTMQQAAGNRLGMSSRQTMRAAQSLYENGYITYMRTDSVTLSHEAIEAAR 345 Query: 337 GYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES-LKDMEADAQKLYQLI 394 +S NFG +YL E P QYA+K +QEAHE IRP+ + S L + D KLY LI Sbjct: 346 ESVSKNFGSQYLSEKPKQYATKTAGAQEAHECIRPAGSHFRDPSQLATLPPDQLKLYTLI 405 Query: 395 WRQFVACQMTPAKYDSTTLTV-----GAGDFRLKARGRILRFDGWTKVM----PALRKGD 445 W++ +A QM A + T G G+ ++ G ++ F G+ +V + +KG+ Sbjct: 406 WQRTLASQMADATGSTATARFAASAGGLGEATFQSSGTVIEFPGFMRVTGERGGSGKKGE 465 Query: 446 EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQ 505 E LP + + L + H T+PPAR++EASLVK LE + IGRPSTYA+IISTI Sbjct: 466 ESASLPPLAESAELPAKSVLADGHETQPPARYTEASLVKTLEAKEIGRPSTYANIISTII 525 Query: 506 DRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD 565 DRGYV R + VT LE F + ++Y FTA MEN LDQ+A+ + L Sbjct: 526 DRGYVYERGRALIPSWLAFAVTRLLETKFPKYVDYQFTADMENGLDQIAHGNETGREWLT 585 Query: 566 HFF----SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG 621 F+ +D + D+A + + + ++ I+ G + +R G +L Sbjct: 586 QFYFGSGADSARSADEAHEGLQRQVAQLGEIDAREINTIPIGDGIHVRVGRYGPYL---- 641 Query: 622 YALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLH 681 + T +L DAE N RA P A D + RKL Sbjct: 642 ---------EDTKDL-------------DAEGNPKRAS--IPDT-IAPDELTVGEARKL- 675 Query: 682 VCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKN 738 + N G R+ G D G + ++ GRFG Y+A E + Sbjct: 676 IASN----------AGGPRVLGTD------PATGGTVEVRNGRFGPYVALVAPESAH 716 >UniRef50_Q2J4Z1 DNA topoisomerase n=10 Tax=Bacteria RepID=Q2J4Z1_FRASC Length = 1049 Score = 413 bits (1061), Expect = e-113, Method: Compositional matrix adjust. Identities = 263/628 (41%), Positives = 346/628 (55%), Gaps = 77/628 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LVIVESPAKAKTI YLG + V+SS+GHIRDLP + +AD + Sbjct: 79 GNRLVIVESPAKAKTIAGYLGPGWQVESSIGHIRDLP------RSAADVPAA-------- 124 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +G R+GVD +++E Y V P K+ VS+LK L + A +YLATD DREGEAIAW Sbjct: 125 -HKGKPWARLGVDVDNDFEPLYIVTPDKKPQVSKLKALVKDASELYLATDEDREGEAIAW 183 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL + + R+VF+EIT AI++A + P +++ + VNAQ+ RR +DR+ GY VSP Sbjct: 184 HLLQTLK-PTVPVKRMVFHEITPQAIQRAVDNPRDIDKNLVNAQETRRILDRLYGYEVSP 242 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD--------------ASTT 227 +LWKK+ LSAGRVQSVA R++VERER F E+W ++ A T Sbjct: 243 VLWKKVMPRLSAGRVQSVATRILVERERARMRFHSAEYWNIEGLFGATVARQAWSGADGT 302 Query: 228 TPSG--------------EALALQVTH--------QNDKPFRPVNKEQTQAAVSLLEKAR 265 SG E L T + F P + + L E Sbjct: 303 PGSGPDGPGAGSIRGDGVEKTPLPATLIALNGNRIATGRDFSPTGQLVSSGVTRLDEATA 362 Query: 266 YSVLER-----------EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA 314 S+ ER E KP P PF+TSTLQQ A +L F ++TM +AQRLYE Sbjct: 363 RSLAERLADAAFTVRSVETKPYRRSPYPPFMTSTLQQEAGRKLRFSSQRTMQVAQRLYEN 422 Query: 315 GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSD- 372 GYITYMRTDSTNLS+ A+ R + +G +Y+P P YA K +N+QEAHEAIRP+ Sbjct: 423 GYITYMRTDSTNLSKTALTAARAQAASLYGPEYVPARPRTYAKKVKNAQEAHEAIRPAGD 482 Query: 373 -VNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG-----DFRLKARG 426 E +++ D+ +LY+LIW++ VA QM A+ S T+ +GA D A G Sbjct: 483 HFRTPGEVRGELDVDSYRLYELIWQRTVASQMADARGTSATIRLGATSSAGEDAEFSASG 542 Query: 427 RILRFDGWTKVM------PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEA 480 +++ F G+ + P D +R LP V +GD LT LTP H T PPARF+EA Sbjct: 543 KVITFPGFLRAYVEGADDPDAELEDRERRLPDVRQGDPLTTRSLTPRGHTTSPPARFTEA 602 Query: 481 SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY 540 SLVK LE+ GIGRPSTYASII TIQDRGYV + + V LE++F L++Y Sbjct: 603 SLVKTLEELGIGRPSTYASIIGTIQDRGYVWKKGSALVPSFVAFAVVGLLEDHFTRLVDY 662 Query: 541 DFTAQMENSLDQVANHEAEWKAVLDHFF 568 FTA ME+ LD +A A L F+ Sbjct: 663 RFTATMEDDLDDIAAGTAASTDWLTRFY 690 >UniRef50_B3DUA2 DNA topoisomerase n=13 Tax=Actinobacteridae RepID=B3DUA2_BIFLD Length = 1028 Score = 413 bits (1061), Expect = e-113, Method: Compositional matrix adjust. Identities = 260/688 (37%), Positives = 363/688 (52%), Gaps = 92/688 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESP KA I YLG Y V +SVGHIRDL + ++ P Sbjct: 1 MATKLVIVESPTKAHKIGDYLGKGYTVMASVGHIRDL---------------AQPSQVPA 45 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 D+ A + GVD ++ +Y V K++ VSELK + AD +YLATD DREGEAIA Sbjct: 46 ADK--AKFGKFGVDVNDGFKPYYIVDGDKKRTVSELKSALKNADELYLATDEDREGEAIA 103 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL + + + R+VF+EITKNAI + N +++ + V+AQ+ RR +DR+ GY +S Sbjct: 104 WHLVQTLK-PEVPVKRMVFHEITKNAINASLNNTRDVDGNMVDAQETRRILDRLYGYELS 162 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP----------- 229 P+LW+K+ GLSAGRVQSVA RL+VERERE AF +W++ A+ + P Sbjct: 163 PVLWRKVGPGLSAGRVQSVATRLIVERERERMAFKRAPYWDIVATLSAPDALGERAEFSA 222 Query: 230 -----SGEALALQVTHQNDKPFRP---------VNKEQTQAAVSLLEKARYSVLEREDKP 275 G+ LA D P +++ A L A ++V+ E KP Sbjct: 223 RMIALGGKRLAGSKDFGADGQLTPDGFAANVRQLDEAGATAVAEALRTADFTVMSMETKP 282 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMV 335 +P PF TSTLQQ A RLG G + M AQ LYE GYITYMRTDS LSQ+A+ Sbjct: 283 YRRRPQPPFTTSTLQQTAGNRLGMGARVVMRAAQSLYENGYITYMRTDSVTLSQEAITAA 342 Query: 336 RGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPS-----DVNVMAESLKDMEADAQK 389 R +S +FG K+L P QYA+K +QEAHE IRP+ D + +A L D + Sbjct: 343 RNAVSYHFGDKFLSAEPKQYATKTAGAQEAHECIRPAGSRFHDPDELASKLP---GDQLR 399 Query: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGA------GDFRLKARGRILRFDGWTKVMPALR- 442 LY LIW++ +ACQM A + T+ + A G+ +A G ++ F G+ K R Sbjct: 400 LYTLIWQRTLACQMADATGSTATVRLSAPAGPTEGEAVFQASGTVIEFPGFMKATGEGRK 459 Query: 443 --------------------------KGD---EDRILPAVNKGDALTLVELTPAQHFTKP 473 +GD + LP ++ G + ++ P H T+P Sbjct: 460 PKAAAPGAGAGSDQAAAAGKTDAKAVRGDASESNTSLPPMSVGQQVEASDIEPDGHETQP 519 Query: 474 PARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEEN 533 PAR++EA+LVK LE + IGRPSTYASIISTI DRGYV R + VT LE N Sbjct: 520 PARYTEATLVKTLEAKEIGRPSTYASIISTIMDRGYVYERGRALIPSWLAFSVTKLLETN 579 Query: 534 FRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF----SDFTQQLDKAEKDPEEGGMRP 589 F +L++Y FTA+MEN LD++A+ E + L HF+ + D+A + ++ + Sbjct: 580 FPKLVDYQFTAEMENGLDRIAHGEESGRDWLTHFYFGSGEGAARNADEAHEGLQQQVAQL 639 Query: 590 NQMVLTSIDCPTCGRKMGIRTASTGVFL 617 ++ +I+ G + +R G +L Sbjct: 640 GEIDARAINTIDIGDGLHVRVGRYGPYL 667 >UniRef50_A8F3N1 DNA topoisomerase n=2 Tax=Thermotogaceae RepID=A8F3N1_THELT Length = 722 Score = 412 bits (1058), Expect = e-113, Method: Compositional matrix adjust. Identities = 265/784 (33%), Positives = 413/784 (52%), Gaps = 114/784 (14%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M ++IVESPAKAKTI + L +Y V SS GH+RDLP Sbjct: 1 MANKIIIVESPAKAKTIKEILKGEYDVLSSKGHVRDLPE--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 GV+ ++E ++++ GKEK+V ELK+ A K + L +D+DREGEAIA Sbjct: 40 --------KEFGVNIEKDFEPTFKIIYGKEKIVQELKKKA-KNKQVLLGSDMDREGEAIA 90 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++G + + +R++FNEIT AI+ A +P +++++V+AQ ARR +DR+VGY +S Sbjct: 91 WHLADILGVANEK-NRIIFNEITPQAIKNAVKEPRNIDMNKVHAQLARRILDRIVGYKIS 149 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWK + SAGRVQS A+++V ERE + F P++FW+V + L +TH Sbjct: 150 PLLWKMLKTSSSAGRVQSAALKIVCEREIQRHKFQPKKFWKVQGYIGS-----LKFYLTH 204 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + K ++ A V++ + + K +PFITSTLQQ A+ +LGF Sbjct: 205 IDGKKIDMQQIDEKLAKEIEKNVKVLKVIQIKTRKIQKKAPSPFITSTLQQEAANKLGFS 264 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 VKKTM +AQ+LYE +ITYMRTDST +S+ A +I+D FGK YL + Sbjct: 265 VKKTMQIAQQLYEGIDTPKGHRAFITYMRTDSTRVSEIAKQKAIEFITDKFGKNYLGKKV 324 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTPAKYDST 411 +K+N Q+AHEAIRP ++++ + ++ D+ D +LY+LIW +F+A QM A Y+ T Sbjct: 325 RTEKAKQNVQDAHEAIRPVNIDLTPDQVEGDLGKDQYRLYKLIWERFMASQMADAIYEET 384 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 T+ + + +++ FDG+ + L+K E I + G+ + + + + T Sbjct: 385 TIQFQSDRYTFESKIERRIFDGFEII---LKKDKEQEI--TIPSGE-IRISKWQIEEDET 438 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPPAR++EAS+V+ LE RGIGRPSTYA+IIST+ +R YV + + MG +V LE Sbjct: 439 KPPARYTEASMVRALEIRGIGRPSTYATIISTLLERKYVIKSSNQLIPTVMGFVVNHYLE 498 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 + F E+++ FTA+ME +LD++ + ++K +L F++DF++ LD+A++ M N Sbjct: 499 KKFPEIVDLQFTAKMEEALDKIEQGQKDYKELLRDFYNDFSKYLDEAQQKWLSIDMNTN- 557 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVL---NVL-- 646 ++C C K ++ G++L C E C T +L E + N + Sbjct: 558 -----LECD-CKSKYKLKVGRYGLYLLC--------ENCSKTTSLALETPAVFYENTMYF 603 Query: 647 ---EGEDAET-----------------NALR-----------AKRRCPKCGTAMDSYLID 675 E E ET N ++ A+ +CPKC ++ + Sbjct: 604 THQEKESIETVCPVCGGKLEQMSGRYGNYIKCQNCGKTYTGFARGKCPKCSAVVEKKISK 663 Query: 676 PKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEE 735 KR C ++ CD I + C +C ++ K R + + C N Sbjct: 664 NKRIFFKCTSD-NCDF---------ISWLEPSNETCPECSQRLYYKKYRSKEVLYCQN-- 711 Query: 736 CKNT 739 CK T Sbjct: 712 CKKT 715 >UniRef50_A1AXT2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A1AXT2_RUTMC Length = 777 Score = 410 bits (1054), Expect = e-112, Method: Compositional matrix adjust. Identities = 247/652 (37%), Positives = 368/652 (56%), Gaps = 84/652 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI K+LG + VKSS+GHIRD+P K Sbjct: 1 MEKNLVIVESPAKAKTIEKFLGKGFSVKSSIGHIRDMP---------------------K 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 K+ MG+D +N+ YE+ K+KVV++L++ + A+ +YLATD DREGEAIA Sbjct: 40 KN--------MGIDIENNFAPTYEITTDKKKVVADLRKAVKAAEKVYLATDEDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E + R+VF+EIT++AI A +P ++ V+AQQARR +DR+VG+ +S Sbjct: 92 WHLLEALNLPKDT-PRIVFHEITESAITHAIVEPRTVDYQLVDAQQARRIIDRLVGFEIS 150 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW+KI+ SAGRVQS +RLVVEREREI + ++V A T+ G ++++ Sbjct: 151 PVLWRKISGARSAGRVQSPVMRLVVEREREISQHITNSTYKVKAELTSEGGGLFEVKLSK 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + +K++ ++ A +V E K P PFITSTLQQ AS +LGF Sbjct: 211 EFE------SKKKVLDFINAFLSANLTVTSIEKKSYKRSPKPPFITSTLQQEASQKLGFS 264 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 VK+TM +AQ LY G+ITYMRTDS LS+ A+++ I FG +Y +Y +K+ Sbjct: 265 VKQTMTLAQNLYREGFITYMRTDSFTLSEIAIDVTGQIIVKEFGSEY--HHIRRYKTKDT 322 Query: 361 S-QEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG- 418 S Q+AHEAIRP+ N+ S+ +E A KLY LI+++ +ACQM+ A+ T + + Sbjct: 323 SAQKAHEAIRPT--NLTKPSIFGIEDQAAKLYSLIYKRTLACQMSDAQLQKTQIKINISG 380 Query: 419 -DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARF 477 D + A IL F G+ +V E+++LP +NK D L+L + F++ R+ Sbjct: 381 LDEKFLANDEILTFPGFLRVYDYF--SSENKLLPDLNKEDMLSLASFKARESFSRAKPRY 438 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR---------------------- 515 +EASLVK++E+ GIGRPST+A+++ST+QDR YV E R Sbjct: 439 TEASLVKKIEEMGIGRPSTFATMVSTVQDRNYVTKETREGVERGYQLIEIKDNQIIQSQP 498 Query: 516 ---------RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 + + + ++TD L + F +++Y+FTA++EN D +A W+ V+ + Sbjct: 499 SEVTGAEKNKLFPTNVAYLLTDFLVKYFNNIIDYEFTAKLENDFDAIATQNISWQGVVKN 558 Query: 567 FFSDFTQQL-DKAEKDPEEG-GMRPNQMVLTSIDCPTCGRKMGIRTASTGVF 616 F++ F +++ D A+ EE GMR D P G+ + +R G F Sbjct: 559 FYTPFHKKIEDAADISREETHGMRE-----LGTD-PKSGKLVSVRFGRYGAF 604 >UniRef50_O34204 DNA topoisomerase 1 n=8 Tax=Thermotogaceae RepID=TOP1_FERIS Length = 699 Score = 409 bits (1050), Expect = e-112, Method: Compositional matrix adjust. Identities = 251/664 (37%), Positives = 364/664 (54%), Gaps = 79/664 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K ++IVESPAKAKTI + LG+DY V SS GHIRDLP + Sbjct: 38 KKVIIVESPAKAKTIERILGNDYQVISSKGHIRDLP----------------------QK 75 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + G +N + +D +E++PGKE VV ++K++ + L +D DREGEAIAWH Sbjct: 76 QFGVDLNSLKLD--------FEIIPGKESVVEQIKKMTS-GKEVLLPSDQDREGEAIAWH 126 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L ++G + F EIT+ AI++A P E+++++VNAQ ARR +DR+VGYM+SPL Sbjct: 127 LSTILGVKGKNI--ITFTEITERAIKEAVKNPREIDMNKVNAQLARRVLDRIVGYMISPL 184 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LW+ I SAGRVQS A++++ ERERE FVP+++++V L +T + Sbjct: 185 LWRIIKDARSAGRVQSAALKIICERERERYRFVPQKYFKVWIDIA-----GLKAYLTKVD 239 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K +P + + + L + +++ + K P APFITSTLQQ A+++LGF V Sbjct: 240 GKKIKPTDITEEISKDVLQKVKSVRLVDIDVKEVRKNPPAPFITSTLQQDAASKLGFPVS 299 Query: 303 KTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN- 353 KTM +AQ LYE +ITYMRTDST +S A +I NFG++YL ES Sbjct: 300 KTMKIAQELYEGVDTKEGHTAFITYMRTDSTRVSDVAKEAAEKFILKNFGREYLNESSEV 359 Query: 354 ----QYASKENSQEAHEAIRPSDVNVMAESLKDM-EADAQKLYQLIWRQFVACQMTPAKY 408 +K Q+AHE IRP DVN+ E K++ + D KLY+LIW++F+A QM+ A Y Sbjct: 360 ASKKGSKTKGKVQDAHECIRPVDVNITPEKAKELLDKDHHKLYELIWKRFIASQMSSAIY 419 Query: 409 DSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQ 468 + +G + +A R FDG+ KV + E V D LVE A+ Sbjct: 420 KQYSYDFESGKYVFEASIRERIFDGFEKVYTIDNEPSEKHKELKV---DQEYLVEPKSAE 476 Query: 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528 T PP R++EASLVK LE GIGRPSTYA+II T+ DRGYV + + +G +V Sbjct: 477 AQTTPPDRYTEASLVKTLEMEGIGRPSTYATIIQTLLDRGYVVKKRKTLIPTILGFVVNH 536 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 LE+ F ++++ FTA+ME LD+V N + +WK V+ F +F + L++A+ Sbjct: 537 YLEQRFPDIVDKGFTAEMEKELDEVENGKKDWKEVVKSFLKEFNKDLERAK--------- 587 Query: 589 PNQMVL----TSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 N+ T I C C ++ G++L C CKT N +++V Sbjct: 588 -NEFFAIDFDTDITCEDCSGNYKLKVGKYGLYLHCPN--------CKT--NKALKSDVFG 636 Query: 645 VLEG 648 V++G Sbjct: 637 VIDG 640 >UniRef50_C4FH65 DNA topoisomerase n=1 Tax=Bifidobacterium angulatum DSM 20098 RepID=C4FH65_9BIFI Length = 996 Score = 407 bits (1045), Expect = e-111, Method: Compositional matrix adjust. Identities = 252/613 (41%), Positives = 334/613 (54%), Gaps = 66/613 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDL--PTSGSAAKKSADSTSTKTAKKP 59 G LVIVESP KA+ I+ YLG Y V +SVGHIRDL P+ AA K Sbjct: 4 GSKLVIVESPTKARKISGYLGDGYTVMASVGHIRDLAQPSQVPAADKEH----------- 52 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 + GVD ++ +Y V K K V++LK +KAD +YLATD DREGEAI Sbjct: 53 --------YGKFGVDVNDGFKPYYIVGADKRKTVADLKSALKKADELYLATDEDREGEAI 104 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 AWHL E + R+VF+EITKNAI+Q+ + +++ D V+AQ+ RR +DR+ GY + Sbjct: 105 AWHLVETLK-PKVPVKRMVFHEITKNAIKQSLEQTRDVDADMVDAQETRRILDRLYGYEL 163 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV----------------D 223 SP+LW+K+ GLSAGRVQSVA RL+VERERE AF +W++ D Sbjct: 164 SPVLWRKVGPGLSAGRVQSVATRLIVERERERMAFTRASYWDIVAKLAAANTQGERVGFD 223 Query: 224 ASTTTPSGEALALQVTHQNDKPFRPVN-------KEQTQAAVSL--LEKARYSVLEREDK 274 A + G L D P QT AA LE A ++V+ E K Sbjct: 224 ARMVSLGGRRLVGSKDFGADGKLTPAGFADNVCQLSQTDAAAVAQELEHAPFTVMSMESK 283 Query: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNM 334 P +P PF TSTLQQ A RLG + TM AQ LYE GYITYMRTDS LS +A+ Sbjct: 284 PYRRRPLPPFTTSTLQQTAGNRLGMSSRATMRAAQGLYENGYITYMRTDSVTLSSEAIAA 343 Query: 335 VRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVM--AESLKDMEADAQKLY 391 R + +FGK +L ++P QY +K +QEAHE IRP+ E + +D KLY Sbjct: 344 ARNAVEYHFGKSFLSDAPKQYDTKTAGAQEAHECIRPAGARFHDPDELATRVPSDQLKLY 403 Query: 392 QLIWRQFVACQMTPAKYDSTTLTV-----GAGDFRLKARGRILRFDGWTKVM-------- 438 LIW++ +A QM A + T+ + G G+ +A G ++ F G+ K Sbjct: 404 TLIWQRTLASQMADATGSTATVKISAPAGGHGEALFQASGTVIDFPGFMKATGEQHHAAK 463 Query: 439 PALRKGDE---DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPS 495 RKG+ + LP ++ G L + ++ H T+PPAR++EASLVK LE + IGRPS Sbjct: 464 QGGRKGENAEGNASLPPMSAGQRLDVADVQADGHETQPPARYTEASLVKTLEAKEIGRPS 523 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 TYASIISTI DRGYV R + V LE F +L++Y FTA MEN LDQ+A+ Sbjct: 524 TYASIISTIIDRGYVYERGRALIPSWLAFAVVKLLETKFPKLVDYQFTADMENGLDQIAH 583 Query: 556 HEAEWKAVLDHFF 568 + + L F+ Sbjct: 584 GKQTGRDWLTRFY 596 >UniRef50_Q6XZ01 DNA topoisomerase n=2 Tax=Spiroplasma RepID=Q6XZ01_SPIKU Length = 664 Score = 406 bits (1044), Expect = e-111, Method: Compositional matrix adjust. Identities = 252/702 (35%), Positives = 385/702 (54%), Gaps = 79/702 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVI+ESP K K + KYLG +Y+V SS GHIR+L T G Sbjct: 1 MAQTLVIMESPTKTKAVEKYLGENYLVLSSEGHIRNLSTKGQYG---------------- 44 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD +E Y++ GK++++ +LKQ A+ AD I LATD DREGEAIA Sbjct: 45 ----------LGVD-IKTFEPSYKMERGKKEIIKKLKQEAKAADLIILATDPDREGEAIA 93 Query: 121 WHLREVIG-GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 +HL EV+ G+ +R RV FNEITK A+ +AF +L+++ V++Q+ RR +DR +G+ + Sbjct: 94 YHLNEVLNCGEKSR--RVRFNEITKEAVLEAFQHQTDLDMNLVHSQETRRILDRFIGFRL 151 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 S LL KKI + SAGRVQSVA++LVVERE+E + FVPEE+W V+ + +++T Sbjct: 152 SKLLQKKI-KSKSAGRVQSVALKLVVEREKEWQNFVPEEYWTVEGLY-----KKAVVKLT 205 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 D + E V K + V++ ++ K P TST+ Q AS+++GF Sbjct: 206 KFKDYKIE-LKVEADVLKVKKALKKDFVVVQIKESEKQRKSPNPHTTSTMLQEASSKMGF 264 Query: 300 GVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 KT ++AQ+LYE G+ITY RTDS LS V YI+ +G +YL Sbjct: 265 ASNKTSLIAQQLYEGIKVKDNITGFITYPRTDSIRLSDKFVQDAFDYITIKYGTEYLGGV 324 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 Q +K+N Q+AHEAIRP+D+ + E+ K+ + D +LY++I+ + +A M AK S Sbjct: 325 KTQPKNKKNVQDAHEAIRPTDLTMTPEAAKEYLSRDQIRLYKIIYNRSLASLMANAKLLS 384 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI-LPAVNKGDALTLVELTPAQH 469 + + ++ + G ++FDG+ K +G+E+ + LP + + L EL QH Sbjct: 385 KAIILDNNNYEFRMTGSTIQFDGFLKCY--FLEGNEEIVKLPMLKPNQIINLNELYGIQH 442 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FTKPP+ +SEA L+K LE+ G+GRPSTYA I+ T++DRGY+ VEN+ A + G + +D+ Sbjct: 443 FTKPPSHYSEAKLIKTLEEIGVGRPSTYAPIMQTLKDRGYIIVENKAIKATEKGILTSDK 502 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 L+E F +++N +T+ +E SLD +A+ +AE K +L F+ F +++ + EE + Sbjct: 503 LQEYFSDIINETYTSTIEKSLDMIAHGDAEPKPLLKEFWERFEPRIEATMELMEEIPVEK 562 Query: 590 NQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE 649 + I+CP CG + R G F+ CSG+ +C P+ Sbjct: 563 -----SGIECPECGNDLVYRYGKYGKFIACSGFP-----KCHYIHQTGPKF--------- 603 Query: 650 DAETNALRAKRRCPKCGTAMDSYLIDPKR-KLHVCGNNPTCD 690 CP+CG + +R + C N P C+ Sbjct: 604 ----------GPCPECGVGEIILKFNKRRQRFKACTNYPNCN 635 >UniRef50_P34185 DNA topoisomerase 1 n=39 Tax=Bacteria RepID=TOP1_SYNE7 Length = 883 Score = 405 bits (1042), Expect = e-111, Method: Compositional matrix adjust. Identities = 239/589 (40%), Positives = 339/589 (57%), Gaps = 41/589 (6%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP KA+TI YL DY V++S+GH+RDLP S S + Sbjct: 4 LVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASDIPTEL---------------K 48 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 G + +GVD +N+ Y V K+K+V LK + AD + LATD DREGE+I+WHL Sbjct: 49 GEKWSNLGVDVENNFAPLYIVPKDKKKIVKTLKDALKDADELILATDEDREGESISWHLL 108 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 +++ R+VF+EIT+ AI+ A +++ V+AQ+ RR +DR+VGY +SPLLW Sbjct: 109 QLLQ-PRVPTKRMVFHEITQEAIQAALKNCRDVDQRLVHAQETRRILDRLVGYTLSPLLW 167 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE------ALALQ- 237 KKIA GLSAGRVQSVAVRL+V+RER +AF +W++ A T +G+ LA Q Sbjct: 168 KKIAWGLSAGRVQSVAVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEAKLWTLAGQR 227 Query: 238 VTHQND-----------KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFIT 286 + ND + +++++ +A L+ + V E+KPTT KP PF T Sbjct: 228 LATGNDFDESTGQIIAGRQVCLLDQQEAEALRDRLQTQPWQVKSLEEKPTTRKPAPPFTT 287 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 STLQQ ++ +L ++TM +AQ LYE G+ITYMRTDS +LSQ A+ R + +GK Sbjct: 288 STLQQESNRKLRLSARETMRVAQSLYERGFITYMRTDSVHLSQQAIEAARSCVEQMYGKN 347 Query: 347 YLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTP 405 YL P Q+ +K +N+QEAHEAIRP+ + LY LIW++ +A QM Sbjct: 348 YLSPQPRQFTTKSKNAQEAHEAIRPAGNTFRLPQETGLSGAEFALYDLIWKRTIASQMAE 407 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------PALRKGDEDRILPAVNKGDAL 459 A+ ++ + + +A G+ + F G+ + P D + +LPA+ GD Sbjct: 408 ARQTMLSVLLEVDNAEFRASGKRIDFPGFFRAYVEGSDDPDAALEDREILLPALKVGDRP 467 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 T EL H T+PPAR++EASLVK LE GIGRPSTYASII TI DRGY ++ + Sbjct: 468 TCQELAAIGHETQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVSNTLTP 527 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 VT LE++F +L++ F+A+ME SLD ++N E +W L F+ Sbjct: 528 TFTAFAVTALLEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYLSQFY 576 >UniRef50_P73810 DNA topoisomerase 1 n=13 Tax=cellular organisms RepID=TOP1_SYNY3 Length = 898 Score = 404 bits (1037), Expect = e-111, Method: Compositional matrix adjust. Identities = 239/595 (40%), Positives = 336/595 (56%), Gaps = 53/595 (8%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP KA+TI YL DY V++S+GH+RDLP S + KD+ Sbjct: 4 LVIVESPTKARTIRNYLPQDYRVEASMGHVRDLPASAEEVPAAY------------KDKS 51 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 A +GV+ ++ Y + K+KVV EL+ + AD + LATD DREGE+I+WHL Sbjct: 52 WA---NLGVNVEDHFSPLYVIPKSKKKVVKELQTALKNADEVILATDEDREGESISWHLL 108 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 +++ R+VF+EIT+ AIR A +++ + V+AQ+ RR +DR+VGY +SPLLW Sbjct: 109 QLLQ-PKVPIKRMVFHEITQEAIRSALENCRDIDENLVHAQETRRILDRLVGYTLSPLLW 167 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV-----------DASTTTPSGEA 233 KKIA GLSAGRVQSVAVRL+V+RER +AF +W++ A T G Sbjct: 168 KKIAWGLSAGRVQSVAVRLIVQRERARRAFKTAGYWDLKAELEQNKNPFQAKLMTLGGTK 227 Query: 234 LALQVTHQNDKPFRP-------------VNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 LA N F P +++ Q A L ++V+ E+KP KP Sbjct: 228 LA------NGSDFDPNTGALLPDKQVVVLDEAQAIALKERLTGKPWAVVNTEEKPGVRKP 281 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS 340 PF TSTLQQ A+ +LG + TM +AQ+LYE GYITYMRTDS +LS AV R + Sbjct: 282 SPPFTTSTLQQEANRKLGISARDTMRVAQKLYEEGYITYMRTDSVHLSDQAVTAARNCVQ 341 Query: 341 DNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFV 399 +GK+YL P QY +K + +QEAHEAIRP+ + ++ LY+LIW++ V Sbjct: 342 QMYGKEYLSPQPKQYTTKSKGAQEAHEAIRPAGTEFRIPNQTGLKDRELALYELIWKRTV 401 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------PALRKGDEDRILPAV 453 ACQM A+ ++ + D +A G+ + F G+ + P +++ ILP + Sbjct: 402 ACQMADARITQLSVLLKVEDAEFRAAGKRIDFPGYFRAYVEGSDDPDAALENQEVILPPL 461 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513 GD E+ H T+PPAR++EASLVK LE G+GRPSTYASII TI DRGYV++ Sbjct: 462 KVGDRPNCREIDTVGHETQPPARYTEASLVKTLESEGVGRPSTYASIIGTIIDRGYVQMR 521 Query: 514 NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 ++ V LE +F +L++ FT++ME LD++A + +W L FF Sbjct: 522 SKALTPTFTAFAVVSLLESHFPDLVDTGFTSRMEQKLDEIAIGKTQWLPYLQGFF 576 >UniRef50_Q83FM2 DNA topoisomerase n=2 Tax=Tropheryma whipplei RepID=Q83FM2_TROWT Length = 841 Score = 402 bits (1033), Expect = e-110, Method: Compositional matrix adjust. Identities = 246/587 (41%), Positives = 346/587 (58%), Gaps = 51/587 (8%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESP K ++ +YLG YVV SSVGHIRDLP A S T K+ Sbjct: 2 KKLVIVESPTKVSSVGRYLGDGYVVMSSVGHIRDLP---------APSGLTPDLKRSAHA 52 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + V+ +++E +Y VL K+KVV EL+ +D + +ATD DREGEAIAWH Sbjct: 53 Q-------FAVNIENDFEPYYVVLENKKKVVEELQSALNNSDELLIATDGDREGEAIAWH 105 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L +V+ R+VF+EIT+ AI A P ++ + V+AQ+ARR +DR+ GY +SP+ Sbjct: 106 LVQVLK-PTVPVRRLVFHEITREAIAYALQHPRPIDENLVDAQEARRILDRLYGYELSPV 164 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LWKK+ GLSAGRVQS A RL+V+RERE F E+ V A S + + +T Sbjct: 165 LWKKVRPGLSAGRVQSPATRLLVDRERERINFKSAEYQAVTADFQVDS-DVFSASLTLFG 223 Query: 243 DKP------FRPVNKEQTQAAV-----------SLLEKARYSVLEREDKPTTSKPGAPFI 285 ++ F + +T A V L K V + KP + P APFI Sbjct: 224 ERKIATGRDFDNLANLKTDALVLDKNLTDRILEELKSKGALDVEAIDSKPYSRNPYAPFI 283 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 TSTLQQ A+ +LGF K+TM AQ+LYE G+ITYMRTDS LS A++ R + +G+ Sbjct: 284 TSTLQQDAAHKLGFSAKRTMRTAQQLYEKGFITYMRTDSPRLSLQAISAARAQVELLYGR 343 Query: 346 KYLPESPNQYASK-ENSQEAHEAIRPS-DVNVMAESLKD-MEADAQKLYQLIWRQFVACQ 402 ++LP+SP Y +K +N+QEAHEAIRP+ +V ES++ + D +LY LIWR+ +A Q Sbjct: 344 EFLPDSPRTYGAKAKNAQEAHEAIRPTGEVFERPESIESVLSVDCMRLYDLIWRRTIASQ 403 Query: 403 MTPAKYDSTTLTVGAGDFRLKAR------GRILRFDGWTKVMPALRKGDEDRILPAVNKG 456 M A+ ++ TLT+ A R+ R G +L G+ KV L+ + ++LP + G Sbjct: 404 MVSARGETVTLTLSA---RIPERSIFVLSGTVLHEKGFLKVYEGLQDLNS-KLLPNLQVG 459 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 D +TLV++ H T PP R++EASLVK LE+ G+GRPSTYA I+STIQ+RGY + NR Sbjct: 460 DQVTLVDVRAVGHTTLPPPRYTEASLVKVLEELGLGRPSTYALILSTIQERGYAHLRNRM 519 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA---NHEAEW 560 + + V + LE F L++YDFTA +E+ LD++A + ++W Sbjct: 520 LVPDWLAFSVVNLLENFFSRLIDYDFTANLEDQLDEIALGSQNRSDW 566 >UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2_CLAMS Length = 1012 Score = 400 bits (1029), Expect = e-110, Method: Compositional matrix adjust. Identities = 262/639 (41%), Positives = 355/639 (55%), Gaps = 76/639 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESPAKAKTI +YLGS Y V++SVGHIRDL + P + Sbjct: 47 KKLVIVESPAKAKTIAQYLGSGYEVQASVGHIRDL---------------IEPKNLPPEL 91 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 ++G L + VD + +E +Y V K+K V++LK+ + AD ++LATD DREGEAIAWH Sbjct: 92 KKGTL-GKFSVDVENGFEPYYVVSDQKKKTVADLKRALKDADELFLATDEDREGEAIAWH 150 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L +V+ R+VF+EITK AI +A + +++ V+AQ+ RR +DR+ GY VSP+ Sbjct: 151 LLQVLK-PKVPVKRMVFHEITKEAIERARDSTRDIDTALVDAQETRRILDRLYGYEVSPV 209 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT--------------- 227 LW+K+ GLSAGRVQS A RLVV+RERE AFV +W++ AS + Sbjct: 210 LWRKVGPGLSAGRVQSAATRLVVDRERERLAFVTASYWDLTASLSPLEQELPFDARLVRI 269 Query: 228 ----TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLE--KARYSVLEREDKPTTSKPG 281 +G + +ND RP++ +A L V E KP T +P Sbjct: 270 DGARIATGRDFDDKGALKNDS--RPLDASSAEALAEALRDPSVPLKVQSVESKPYTRRPA 327 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 APF TSTLQQ A+ +L F ++TM +AQ LYE GYITYMRTDS +LSQ A+N R ++ Sbjct: 328 APFTTSTLQQEAARKLRFSARQTMSVAQSLYENGYITYMRTDSPSLSQQAINAARKQAAE 387 Query: 342 NFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNV-----MAESLKDMEADAQKLYQLIW 395 +G + +P+ P YA K +N+QEAHEA+RP+ +A +L+ + KLY LIW Sbjct: 388 LYGPETVPDKPRLYAGKSKNAQEAHEAVRPAGETFRTPQQLASTLR---GNDHKLYDLIW 444 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDF------RLKARGRILRFDGWTKVMPALRKGDEDRI 449 ++ +A QM AK + ++ + AG A G ++ F G+ R DE+R Sbjct: 445 KRTIASQMADAKGSTASVVIAAGPTSAGEVAEFAASGTVITFRGFLAAYEESR--DEERH 502 Query: 450 ---------LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASI 500 LP + KG L LV++ H T PP R++EASLVK LE+ GIGRPSTYA+I Sbjct: 503 GAAEPREAKLPDLKKGQDLRLVDVDAKGHETSPPPRYTEASLVKTLEELGIGRPSTYAAI 562 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 ISTI DRGYV + V LEE F EL+ YDFTA ME+ LD++A AE Sbjct: 563 ISTIVDRGYVTPRGTALVPNWIAFSVVRLLEEFFTELVQYDFTAGMEDDLDRIAEGAAER 622 Query: 561 KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDC 599 L F+ + A K G+RP L ID Sbjct: 623 VDWLKGFYYG-----NDAHK-----GLRPTIDNLGEIDA 651 >UniRef50_C0W593 DNA topoisomerase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W593_9ACTO Length = 931 Score = 398 bits (1023), Expect = e-109, Method: Compositional matrix adjust. Identities = 271/684 (39%), Positives = 370/684 (54%), Gaps = 87/684 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP K ++I YLGSD+ V++SVGHIRDL + ++ P Sbjct: 1 MSKKLVIVESPNKVRSIAGYLGSDFDVEASVGHIRDL---------------AQPSELPA 45 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +++G + VD H ++ +Y V P K+K V++LK+ + AD +YLATD DREGEAIA Sbjct: 46 AEKKGPY-GKFAVDVEHGFKPYYVVNPDKKKTVAQLKKALKDADELYLATDDDREGEAIA 104 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL EV+ R+ F EITK A+ +A EL+ DRV+AQ+ RR +DR+VGY VS Sbjct: 105 WHLLEVLK-PKVPVKRMTFTEITKEAVTRALESTRELDTDRVDAQETRRILDRLVGYEVS 163 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS---------- 230 P+LW+K+ GLSAGRVQSVA RLVVERERE AF +W V+A T Sbjct: 164 PVLWRKVRAGLSAGRVQSVATRLVVERERERMAFKAAGYWGVEAELGTTGSLEESGRTFT 223 Query: 231 -------GEALALQVTHQNDKPFRP---------VNKEQTQAAVSLLEKARYSVLEREDK 274 G +A +D RP +++ +A + + +V E E K Sbjct: 224 ARLATLDGRRVATGRDFGDDGALRPAAVKAHTVHLHEGGARAVADAVMASAPTVTEMETK 283 Query: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNM 334 P +P APF TSTLQQ AS +L ++TM +AQ LYE GYITYMRTDST LS AV Sbjct: 284 PYKRRPAAPFTTSTLQQEASRKLRMNPRETMRVAQGLYENGYITYMRTDSTVLSGQAVAA 343 Query: 335 VRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPS--DVNVMAESLKDMEADAQKLY 391 R +++ +G +Y+P P YA+K + +QEAHEAIRP+ A+ + +LY Sbjct: 344 ARAQVAELYGAQYVPAKPRLYATKTKGAQEAHEAIRPAGDHFRTPAQVAGALSGAQFRLY 403 Query: 392 QLIWRQFVACQMTPAKYDSTTLTV---------GAGD----FR---LKARGRILRFDGWT 435 +LIW++ VA QM A + T+ V GA D FR A G ++ F G+ Sbjct: 404 ELIWKRTVASQMADAVGQTATVKVEVPLKEAKGGARDSGVTFRTAGFTASGTVITFRGF- 462 Query: 436 KVMPALRKG-DEDRI----------------LPAVNKGDALTLVELTPAQHFTKPPARFS 478 + A +G D +R LPA+ GD L + H T PP R++ Sbjct: 463 --LAAYEEGRDAERYEAEPGKAGAASAGEVRLPAMEVGDVLDAKVAEASGHETTPPPRYT 520 Query: 479 EASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELM 538 EASLVK LE+R IGRPSTYA+ +STI DRGYV + + VT LEENF EL+ Sbjct: 521 EASLVKALEEREIGRPSTYAATMSTIADRGYVEHRGQALVPTWLAFAVTRLLEENFSELV 580 Query: 539 NYDFTAQMENSLDQVANHEAEWKAVLDHF-FSDFTQQLDKAEKDPEEG--GMRPN--QMV 593 +YDFTA ME LD++A E + A L F + D Q + + PE+G M N ++ Sbjct: 581 DYDFTASMEADLDRIAAGEEDRVAWLTRFYYGDGDGQGAQPGEGPEQGLKAMLDNLGEID 640 Query: 594 LTSIDCPTCGRKMGIRTASTGVFL 617 +++ G + +R G +L Sbjct: 641 ARAVNSIEIGEGITLRVGRYGPYL 664 >UniRef50_C3JAB5 DNA topoisomerase n=3 Tax=Bacteria RepID=C3JAB5_9PORP Length = 837 Score = 392 bits (1006), Expect = e-107, Method: Compositional matrix adjust. Identities = 245/621 (39%), Positives = 344/621 (55%), Gaps = 91/621 (14%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKAKTI K+LG + V SS GHIRDL SG Sbjct: 56 LVIVESPAKAKTIEKFLGKGFRVLSSYGHIRDLKKSG----------------------- 92 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +G+D + +Y V K VV +LK A+ A+ ++LA+D DREGEAIAWHL Sbjct: 93 ------LGIDISQQFAPNYIVSKDKLAVVRDLKHAADNAEMVWLASDEDREGEAIAWHLY 146 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 EV+ R+VF+EIT+ AI A P +++++ V+AQQARR +DR+VG+ +SP+LW Sbjct: 147 EVLERAGKPTKRIVFHEITQQAIDYAIAHPRDIDLNLVDAQQARRVLDRIVGFELSPILW 206 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS----TTTPSGEALALQV-- 238 K+I LSAGRVQSVAVRL+V+REREI+ F P ++V AS T + +A+A + Sbjct: 207 KRIKPALSAGRVQSVAVRLIVDREREIQQFSPSSSYKVIASLCKQTEGETLQAIAEKTFD 266 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 T + K F N Q +SL+ KP P APF TSTLQQ A+ +LG Sbjct: 267 TAEEAKNFLSRNSAQEMEVLSLV-----------SKPGKRSPAAPFTTSTLQQEAARKLG 315 Query: 299 FGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK 358 + V TM +AQ+LYE+G+ITYMRTDS NLS A+N I + +G+ Y + SK Sbjct: 316 YTVGTTMRIAQKLYESGHITYMRTDSVNLSTLALNSAAKAIKERWGESYYQLRKYKTKSK 375 Query: 359 ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV--G 416 +QEAHEAIRP+D++ ES+ + QKLY++I ++ +A QM + TT T Sbjct: 376 -GAQEAHEAIRPTDLS--KESISGTPQE-QKLYEMIHKRTLASQMADVVLEKTTATFRGQ 431 Query: 417 AGDFRLKARGRILRFDGWTKVMPALRKGDED------RILPAVNKGDALTLVELTPAQHF 470 + A G ++RF+G+ K DE+ LP ++KG+ L EL +H Sbjct: 432 TSNDVFVAEGEVIRFEGFLKAYDYASHSDEEEEKNNSHQLPTLSKGELLNTQELVATEHI 491 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV-------------------- 510 T+ PAR+SEASLV+ LE+ GIGRPSTYA I IQ R YV Sbjct: 492 TRAPARYSEASLVRRLEELGIGRPSTYAPTIQVIQAREYVQKGTGNGTEHQYHDYICNAQ 551 Query: 511 ------RVENRRFYAEK-------MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHE 557 ++ + A+K +G +V D L ENF ++++Y+FTAQ+E D++A + Sbjct: 552 HPTPTLKIRTEKIGADKGKLLPTDIGIVVNDFLVENFPKVIDYNFTAQVEGLFDRIAEGK 611 Query: 558 AEWKAVLDHFFSDFTQQLDKA 578 W ++HF++ F ++ A Sbjct: 612 EIWTNTMEHFYTLFHPMVETA 632 >UniRef50_C1E9E3 DNA topoisomerase n=1 Tax=Micromonas sp. RCC299 RepID=C1E9E3_9CHLO Length = 1227 Score = 373 bits (957), Expect = e-101, Method: Compositional matrix adjust. Identities = 272/818 (33%), Positives = 403/818 (49%), Gaps = 128/818 (15%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LV+VESPAKA ++ KYLG Y V +S GH+RDL Sbjct: 136 LVVVESPAKATSVQKYLGDGYTVLASYGHVRDL--------------------------- 168 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 + GV P ++ A ++ VV ++ + A+ A + LATD DREGEAI+WH+ Sbjct: 169 --VQKNGGVKPEDDF-AMLWAEKARDGVVRDIVKNAKGAAELLLATDPDREGEAISWHIV 225 Query: 125 E------VIGGDDAR-YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGY 177 E V+G + RV F E+TK A+R+AF P E++ V+A ARR +D + G+ Sbjct: 226 ELLREKGVLGSSSSLPVKRVTFTEVTKKAVREAFESPREISAPLVDAYLARRALDYLFGF 285 Query: 178 MVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST--TTPSGEALA 235 +SP+LW+K+ LSAGRVQS A+RLV ERE EI+ FV EEFW V A SG + Sbjct: 286 TLSPVLWRKMPGALSAGRVQSAALRLVCEREFEIERFVKEEFWNVFAGLEPDGSSGRSFV 345 Query: 236 LQVTHQNDK---PFRPVNKEQTQAAVSLLEKAR--YSVLEREDKPTTSKPGAPFITSTLQ 290 ++TH + K P ++E + A + A +V + +K + +P PF TSTLQ Sbjct: 346 GELTHLDGKRLGKMEPGSREAAELAARAVLSASSTLAVHDVVEKDVSRRPRPPFTTSTLQ 405 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA-----GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 Q AS+RLGFG +TM AQ LYE G ITYMRTD ++S AV +R FG+ Sbjct: 406 QDASSRLGFGAARTMAAAQSLYEGRGWGEGLITYMRTDGLHVSPAAVAELRDVAGAEFGE 465 Query: 346 KYLPESPNQYAS-KENSQEAHEAIRPSDVNVMAESLKD---MEADAQKLYQLIWRQFVAC 401 +Y+PE PN + ++N+QEAHEAIRP+ ++ +++ + +D +LY+LIW + +A Sbjct: 466 EYVPEKPNFFRKVQKNAQEAHEAIRPTKAGILPQAVANRLGSGSDEARLYRLIWARTMAS 525 Query: 402 QMTPAKYDSTTLTVGAGD--FRLKARGRILRFDGWTKVMP-ALRKGDE-------DRILP 451 QM+ A V + D RLKA G L F G+ +R GD+ DR LP Sbjct: 526 QMSAAVTKRVQADVWSEDERLRLKATGSRLIFPGYLAAYKHGMRDGDDSTSFGDNDRWLP 585 Query: 452 AVNK-------GDALTLVE--------------------------------LTPAQHFTK 472 ++ GD + +VE +T QH+T+ Sbjct: 586 RLDVGEKIRVIGDEVKIVERDKDAKRGGFKKADADDDGEHEIDTTAGKDTGVTATQHWTQ 645 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR--FYAEKMGEIVTDRL 530 PP R++E SLVK LE++GIGRPSTYA+I+ I+ RGYV E+ R E G +V+ L Sbjct: 646 PPGRYTEGSLVKALEEKGIGRPSTYATIMKVIKRRGYVAGESGRGPLIPETRGRLVSSFL 705 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 F E ++Y FTA +E+ LD +A+ + +WK+VL F+ F ++ + G+R + Sbjct: 706 AHFFDEYVDYGFTAGLEDRLDDIASGKEDWKSVLSGFWGPFAGDVESLK------GIRTS 759 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 Q V+ +D G +S L A + P Sbjct: 760 Q-VVDVLDATLGAHFFGDDESSVDARLSAIERAAEEAATQAESTGGYPTVAF-------- 810 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE--IEEGEFRIKGYDGPI 708 + L + RRCP CGT + C N P+C + +G+ + G + PI Sbjct: 811 -DPEELSSTRRCPGCGTGRLGLKLSRTGGFIGCSNYPSCGHTRQLVNDGDGAVGGGNFPI 869 Query: 709 VECE--KCGSEMHLKMGRFGKY----MACTNEECKNTR 740 + G ++ ++ G +G Y M + ++ K T+ Sbjct: 870 ELGTDPESGGDVAIQNGPYGPYIELQMPSSPDDSKKTK 907 >UniRef50_C5Z4V5 DNA topoisomerase (Fragment) n=12 Tax=cellular organisms RepID=C5Z4V5_SORBI Length = 1094 Score = 370 bits (951), Expect = e-101, Method: Compositional matrix adjust. Identities = 230/673 (34%), Positives = 357/673 (53%), Gaps = 87/673 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K++V+VES KAK I YLG Y V S GH+RDL +K + Sbjct: 309 AKSVVVVESATKAKVIQNYLGDMYEVLPSYGHVRDL---------------AGRSKSVRP 353 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 D+ ++V + W + ++ L G E ++ LA+D DREGEAIAW Sbjct: 354 DDDFSMVWEVPAAAWTHLKSIKVALKGAENLI--------------LASDPDREGEAIAW 399 Query: 122 HLREVIG-----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 H++E++ G D +RV F+EIT++AI++A P +++D VNA ARR +D ++G Sbjct: 400 HIKEMLEQQGALGCDVTVARVAFHEITEDAIKKALMSPRYIDMDLVNAYLARRSLDYLIG 459 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS-----TTTPSG 231 + +SPLLW+K+ SAGRVQS A+ LV +RE EI+ F P+E+W V P+G Sbjct: 460 FGISPLLWRKLPGCQSAGRVQSAALALVCDREAEIEQFKPQEYWTVQTYFKMHFADPPNG 519 Query: 232 EALALQVTHQNDKPFRPVN---KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 + ++ H N K ++ +E+ QA + +++ VL + P P+ITS+ Sbjct: 520 TYIPFRIKHLNSKKLDQLSIRSQEEAQAIEKRIHSSKFEVLGVKRSKIHKNPPMPYITSS 579 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYI 339 LQQ A+ +L F TM +AQ+LYE G ITY+RTD ++S A +R + Sbjct: 580 LQQDAANKLHFTAGYTMKIAQKLYEGINLSSEETTGLITYIRTDGFHVSDGAAEDIRSLV 639 Query: 340 SDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQ 397 + +G+KY+ E +Y K +N+QEAHEAIRP+ + + SL ++ D+ KLY LIW++ Sbjct: 640 KERYGQKYVSEDTRKYLKKVKNAQEAHEAIRPTSIRRLPSSLVGILDDDSLKLYTLIWKR 699 Query: 398 FVACQMTPAKYDSTTLTVGA--GDFRLKARGRILRFDGW------TKVMPALRKGDEDRI 449 +ACQM ++ + + +G G+ + L F G+ T+ +P + D + Sbjct: 700 TMACQMEASRTEMIQVDIGTPEGEMIFHSVASKLDFKGYQAVYEDTEAIPCSDNSERDSV 759 Query: 450 -------LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 L + D + V + QHFTKPP+R+SE +L+K+LE+ GIGRPSTYASI+ Sbjct: 760 DEDNFEALSKLMVKDLVFPVNVHLGQHFTKPPSRYSEGALIKKLEELGIGRPSTYASIMK 819 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 +QDR YV ++R + E G +V+ L +F E+ +Y FTA ME LD V+ EWK Sbjct: 820 VLQDRKYVTAKSRVLHPEFRGRMVSAFLLHHFSEVADYSFTANMETELDNVSAGSTEWKG 879 Query: 563 VLDHFFSDFTQ------QLD--KAEKDPEEGGMRPNQMVLTSID-----CPTCGR---KM 606 +L ++ F + +LD K E+ EE + ++ +D CP+C + Sbjct: 880 LLKDYWERFNKYCADASKLDGRKVERMLEE---KFGPILFPDVDKDSRICPSCSEGTLRF 936 Query: 607 GIRTASTGVFLGC 619 + G F+GC Sbjct: 937 KVSRYGEGYFIGC 949 >UniRef50_A4RYV6 DNA topoisomerase (Fragment) n=5 Tax=cellular organisms RepID=A4RYV6_OSTLU Length = 840 Score = 369 bits (946), Expect = e-100, Method: Compositional matrix adjust. Identities = 235/671 (35%), Positives = 349/671 (52%), Gaps = 82/671 (12%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 + L+IVESPAKAKTI KYLG++ V +S GH+RDL Sbjct: 68 RTLMIVESPAKAKTIEKYLGANAKVLASYGHVRDL------------------------- 102 Query: 63 ERGALVNRMG-VDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 VN+ G V P ++ + ++ + ++ + +K D + LATD DREGEAI+W Sbjct: 103 -----VNKQGSVRPEESFAMTWTSTSRQKAAMRDITEALKKTDVLLLATDPDREGEAISW 157 Query: 122 HLREVIGG-----DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 HL EV+ DD RV F EITK A+ A P ++N+ V+A ARR +D + G Sbjct: 158 HLLEVLREKKLLRDDLDVKRVTFGEITKTAVLDAVGSPRDINVPMVDAYMARRALDYLFG 217 Query: 177 YMVSPLLWKKI--ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEAL 234 + +S LLW+K+ + LSAGRVQSVA+RLV ERE E++AFV E +W V AS ++ G Sbjct: 218 FTLSGLLWRKLPSSVSLSAGRVQSVALRLVCEREEEVEAFVSEPYWTVKASLSSKDGSTF 277 Query: 235 ALQVTHQNDKPFRPV----NKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 +TH + N E A + E V+E + G PF TST+Q Sbjct: 278 DAALTHVDGAKLGKFTIASNDEAEAYAKRVRECDTLRVVEVKHSEAKRTSGPPFTTSTMQ 337 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA-----GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 Q A+ +LGFG +TM AQRLYE G ITYMRTD T ++ A+ +R + FG Sbjct: 338 QEANKQLGFGASRTMSAAQRLYEGAGTGEGLITYMRTDGTYVAPHAIESLRTTAGELFGD 397 Query: 346 KYLPESPNQYASKE-NSQEAHEAIRPSDVNVMAESLKDM---EADAQKLYQLIWRQFVAC 401 +Y+PESP + K+ N+QEAHEAIRP+ + + +D +LY LIW + +A Sbjct: 398 EYVPESPRYFKKKQKNAQEAHEAIRPTKAGRLPAQVARQIGPGSDEARLYALIWARTMAS 457 Query: 402 QMTPAKYDSTTLTVGAG--DFRLKARGRILRFDGWTKVM----PALRKGDEDRILPAVNK 455 QM+PA D + + D +LKA G L+F G+ P +D LP + + Sbjct: 458 QMSPALTDRIAAEIASAENDLKLKANGHRLKFPGFLAAYRTSRPEAAPPSDDAWLPILGE 517 Query: 456 GDALTL------VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 G+ L++ + +H T PP R+++ S+VK LE+RGIGRPSTYA I+ + R Y Sbjct: 518 GEGLSVKTDGESLGCEATEHKTSPPPRYTDGSIVKALEERGIGRPSTYAPILKVLAQREY 577 Query: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 V + G +V+ L F ++Y FTA +E+ LD + + + +WK +L+ +++ Sbjct: 578 VAKQGAALVPTTRGRLVSAFLTNYFETYVDYGFTADLEHKLDDITSEQVQWKPLLEEWWT 637 Query: 570 DFTQQLDKAEK----------DPEEG------GMRPNQMVLTSIDCPTC--GRKMGIRTA 611 F ++ + D + G + +V + CP+C GR +G++ + Sbjct: 638 PFRDKISSLSELRVSEVIDALDEKLGQHLFGEATDSDDVVSEARRCPSCKIGR-LGLKPS 696 Query: 612 STGVFLGCSGY 622 G F+GCS Y Sbjct: 697 KAGGFIGCSRY 707 >UniRef50_C6XEP4 DNA topoisomerase I n=1 Tax=Methylovorus sp. SIP3-4 RepID=C6XEP4_METSD Length = 590 Score = 368 bits (944), Expect = e-100, Method: Compositional matrix adjust. Identities = 248/646 (38%), Positives = 346/646 (53%), Gaps = 70/646 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP KAK +++YLGS+Y+VK+S GH+RDLPTS Sbjct: 1 MSKTLIIVESPTKAKKLSEYLGSEYLVKASFGHVRDLPTSN------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +G P +E YEV + LK ++ D + LATD DREGEAI+ Sbjct: 42 --------GEIGYHP-ETFEPIYEVTEKARTTIKVLKAAVKECDRVLLATDPDREGEAIS 92 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E++G + RV F+EIT +AI +A N P ++ V AQ+ARR +DR VG++VS Sbjct: 93 WHLAELLGLR--KRERVKFHEITASAILKAINTPSAIDTSLVRAQEARRIIDRQVGWLVS 150 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 L +KI + SAGRVQS A+ LVVEREREI AF E F+ V+A + G Sbjct: 151 GPLTRKIGQRASAGRVQSPALALVVEREREILAFKKEAFFTVEAEFSEEWGAVW------ 204 Query: 241 QNDKPFRPVNKEQTQ---AAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 P +++Q + A ++ E ++SVLE + P PF TS L QAAS L Sbjct: 205 -------PSDEQQCKDRSVAETIAESKQFSVLEYDLSKLHEDPPPPFRTSKLLQAASVVL 257 Query: 298 GFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 GF K+TM +AQ L++ G I+Y RTD +N+S DA M+ Y + + P S + Sbjct: 258 GFDPKRTMDLAQSLFQKHGAISYHRTDESNISDDAYGMIVEYGQE----RNYPMSSEKRT 313 Query: 357 SKE--NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLT 414 K +QEAHEAIRPSD+N + + M AD LY+LI + VA QM PA+Y T T Sbjct: 314 WKGVVAAQEAHEAIRPSDMNYQPD--ETMTADEAALYRLIHSRAVASQMEPAEYTVATAT 371 Query: 415 VG-AGDFRLKARGRILRFDGWTKVMPALRKGDEDRIL---PAVNKGDALTLVELTPAQHF 470 + + KA+ + L GW + + D++ L P ++ G L +T +H Sbjct: 372 LSNEQGIKFKAQSKSLCKPGWRVLAVQDEEHDDNPSLSHIPDLSVGQILHSSNVTVCEHS 431 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP R+++ASL LE+ GIGRP+TYAS++ + DR YV+V R E +G + D L Sbjct: 432 TRPPKRYTKASLTNALERLGIGRPATYASMVDGLTDRSYVQVVERFLTPEPVGFAIYDAL 491 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 + F + ++T ME+ LD + + +++V+ +SD T +L G P Sbjct: 492 KGAF-SFIETEYTRGMESDLDLIVKGDKTYRSVVSSKYSDLTTELASF-----GGAEIPR 545 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 T CP CG+ M RT S G FLGCSGY PK CK T L Sbjct: 546 PAPSTVGSCPKCGKGMVQRTGSRGPFLGCSGY---PK--CKETQQL 586 >UniRef50_D0JAY2 DNA topoisomerase n=2 Tax=Blattabacterium RepID=D0JAY2_BLASB Length = 704 Score = 367 bits (942), Expect = e-99, Method: Compositional matrix adjust. Identities = 235/689 (34%), Positives = 360/689 (52%), Gaps = 87/689 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESP KA TI +LG DY V SS GHI DLP Sbjct: 1 MKENLVIVESPTKAYTIQTFLGKDYYVVSSYGHIIDLPEK-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GV+ N++ +Y +L K+K+V LK L + I+LA+D DREGEAIA Sbjct: 41 ---------EIGVEIKDNFKPNYVILSKKKKIVQNLKILIKNHKIIWLASDEDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 + + + D +Y R+VF+EITK AI A P +N D V AQQARR +DR+VG+ +S Sbjct: 92 YQIYKTFNIPDRKYRRIVFHEITKKAIFNAIKNPRSINYDLVYAQQARRILDRLVGFQLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ RGLSAGRVQS AV+L+VE+E +I+ F+P ++V + ++ Sbjct: 152 PVLWKKVKRGLSAGRVQSAAVKLIVEQENKIQKFIPSPTYQVYGVFSNEQKMIFNAKLDK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + + N +SL + + V + K P PF TS+LQQ A +L + Sbjct: 212 KIEDKKKMKN------ILSLCINSSFLVKKIVIKHEKKNPPPPFTTSSLQQEACKKLNYS 265 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYAS-KE 359 + KTM +AQ+LYE G+ITYMRTDST+LS+D ++ ++ YI +GKKYL S +++ ++ Sbjct: 266 ISKTMFLAQKLYEKGFITYMRTDSTSLSKDILSEIKDYILSLYGKKYL--STKEFSKGQK 323 Query: 360 NSQEAHEAIRPSDVNVMAES-LKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG 418 SQEAHE+I P+ +N + + L ++ ++LYQLIW + + QM + + + + Sbjct: 324 FSQEAHESIHPTVINHIDNNYLNFLDIYQKRLYQLIWERTIMGQMIDSVIEKKDFYIQSS 383 Query: 419 ---DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPA 475 DF + + +L DG+ K++ E + + +G L E+ Q Sbjct: 384 HFDDFFIWTKRTVL-LDGFMKIVNQDENKKEKLSVLEMKQGTHLQRKEIIAKQIIPSRIH 442 Query: 476 RFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV------------------------- 510 R++EASLV LEK GIGRPSTY IIS IQ R YV Sbjct: 443 RYNEASLVNNLEKLGIGRPSTYVPIISAIQKRNYVSIQKIIKKTETRKNFLLKGNSIIEK 502 Query: 511 -----RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD 565 +E +F ++G ++T+ L++NF E+++Y+FTA +E + D +A + W +L Sbjct: 503 NEQITEIEKNKFIPTEIGVLITNFLKKNFAEIVDYNFTANLEKNFDDIAKGKQSWIKILQ 562 Query: 566 HFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALP 625 +F+ +F +++ EE + ++ ID P +K+ + A G + + Sbjct: 563 NFYDEFHKKIQYV----EEYVDKIHKERFLGID-PKSNKKIFSKIARFGPIVQMGEFK-- 615 Query: 626 PKERCK-------TTINLVPENEVLNVLE 647 KE+ K TIN + E L +LE Sbjct: 616 DKEKPKFSPLLNSQTINTISFTEALKILE 644 >UniRef50_O66893 DNA topoisomerase 1 n=2 Tax=Aquificaceae RepID=TOP1_AQUAE Length = 540 Score = 361 bits (926), Expect = 9e-98, Method: Compositional matrix adjust. Identities = 223/580 (38%), Positives = 330/580 (56%), Gaps = 53/580 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L IVESP KAKTI K+LG ++VK+++GH++DLP Sbjct: 3 LFIVESPTKAKTIQKFLGKGFLVKATLGHVKDLPE------------------------- 37 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +GVD +A Y GK+K+V +LK+L+ ++ +YL TD DREGEAIA+ L+ Sbjct: 38 ----KELGVD-LRTLKAKYVYKRGKKKLVEQLKKLSRRSSIVYLGTDPDREGEAIAYFLK 92 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 + + + R VF EIT AIR++ G++N++ V AQ ARR +DR++GY++SP+LW Sbjct: 93 KDLEKVNKNIKRAVFYEITPEAIRESIRNAGDVNMNLVYAQFARRILDRLIGYLISPILW 152 Query: 185 KKIAR-GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 K+ LSAGRVQS A+RL+VEREREI+ F ++++ V A S E A+ Sbjct: 153 KEFKNYKLSAGRVQSPALRLIVEREREIQNFKVKKYYYVKALLRKGSEEFWAIY------ 206 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 +R N + LEK +SV + E K P PFITS LQ A+ + GF ++ Sbjct: 207 -DYRYENPSDAKIIAKKLEKGYFSVYKVEKKKEKVSPPKPFITSDLQSEANAKFGFSSER 265 Query: 304 TMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQE 363 T +AQ LYE GYITY RTDS +++ YI +GK+Y+ ++ K +Q Sbjct: 266 TQKLAQELYEKGYITYPRTDSYRMNEKKAKEFMNYIEKKYGKEYVGRL-RRFREKATAQG 324 Query: 364 AHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLK 423 AHE IRP+ + E + + E + + LY LI+R+ +A M + +TV A LK Sbjct: 325 AHECIRPTSLR---EEIPERE-ELRLLYDLIFRRTIASLMKEMLLEREKVTVEAITPELK 380 Query: 424 ------ARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARF 477 A+G + FDGW++V P+ + E++ LP + +GD L LV+ T + T+PP R+ Sbjct: 381 HPVYLVAKGLKIVFDGWSRVYPS--EITEEK-LPELYEGDLLDLVKTTLEERKTQPPPRY 437 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFREL 537 +E +L+K LEK GIGRPSTYA+I+ T+++RGYV V+ + ++ V + L E F L Sbjct: 438 TEGTLIKTLEKLGIGRPSTYATIVKTLKERGYVEVKKKALVPTEIAFQVVEFLMERFPTL 497 Query: 538 MNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD-FTQQLD 576 M+Y FTAQME LD V + WK+V+ F F ++L+ Sbjct: 498 MDYKFTAQMEEKLDLVEEGKLNWKSVVYEFMEKIFGKELE 537 >UniRef50_B7I2H2 DNA topoisomerase n=4 Tax=Proteobacteria RepID=B7I2H2_ACIB5 Length = 672 Score = 360 bits (925), Expect = 1e-97, Method: Compositional matrix adjust. Identities = 258/714 (36%), Positives = 364/714 (50%), Gaps = 95/714 (13%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP K K I+ LG+ Y V +SVGH+RDLP PK+ Sbjct: 4 LVIVESPGKVKKISALLGAGYKVVASVGHVRDLP--------------------PKE--- 40 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +G++P ++ HY+ V++ LK+ AD I LATD DREGEAIAWHL Sbjct: 41 ------LGIEP-PDFRPHYQPTERGRDVLARLKKDVAAADRILLATDPDREGEAIAWHLA 93 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 + + D + R+ F ITK+ ++ A P ++++RV +Q+ARR +DR+VGY VSP L Sbjct: 94 DALKLRDPQ--RITFTAITKDKVQAAVAAPRRIDMNRVRSQEARRALDRIVGYRVSPALS 151 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDK 244 + + LSAGRVQS AVRLVV+REREI +F E + A T +G+ A + Sbjct: 152 DRAGQPLSAGRVQSPAVRLVVDREREIASFKVTEHY--GAELTFDNGDGTAWRAVWDTKP 209 Query: 245 PFRPVNKEQTQAAVSLLEKA--RYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 A++L A +V E D P APF TSTLQQAA RL K Sbjct: 210 HMAEGESYIMDDALALRVAAVRHVTVAEVADTEKGRAPAAPFTTSTLQQAAGQRLKLRPK 269 Query: 303 KTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQ 362 KTM +AQRLYE G ITY RTD+ N+ + + Y L E P ++ +KE +Q Sbjct: 270 KTMELAQRLYEQGAITYHRTDAPNMDDAGMEDIAAYARS--AGLPLAEKPRRWKAKEGAQ 327 Query: 363 EAHEAIRPSDVNVMAESLKDMEADAQK-LYQLIWRQFVACQMTPAKYDSTTLTVGAGD-- 419 E HEAIRP+ A L+ E D +K LY+LIW++ VA Q+ A Y ++ + AGD Sbjct: 328 EGHEAIRPT----HAADLEAGETDDEKALYRLIWQRAVASQLADAIYAVRSVRL-AGDAE 382 Query: 420 ---FRLKARGRILRFDGWTKV-----MPALRKGD-EDRILPAVNKGDALTLVELTPAQHF 470 A GR L+ GW V + +G+ + +PA+ +G LT Sbjct: 383 GLAVAFTATGRTLQSPGWMAVYAADADDSDDEGEASNNPIPALAEGAGLTASSGRLLTKH 442 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFY--AEKMGEIVTD 528 TKPP RF+EA+LVKE+E+ GIGRPSTYA+II I RGYV +E ++ Y +GE + D Sbjct: 443 TKPPTRFTEATLVKEMERLGIGRPSTYAAIIENITGRGYV-IEGQKGYLTPSPIGETIRD 501 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 L FR D+T +E+ LDQ+A +A+++ V+ +S +L K + Sbjct: 502 ALVGRFR-FAELDYTRGLEDELDQIAEAKADYQGVISAAWSALDDELGKLD--------- 551 Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 + + + CP CG+ + R G F C+GY CKT++ P++ +G Sbjct: 552 -SAGIAAAHPCPACGKALHRRKGQYGFFWSCTGY-----PECKTSL---PDD------KG 596 Query: 649 EDAETNALRAKR--RCPKCG--TAMDSYLIDPKRK--------LHVCGNNPTCD 690 + + A +CPKCG A + PK+K + C P CD Sbjct: 597 KPGQRKAPPPSTGFQCPKCGKELARRQGVSKPKKKGMKGRPYDFYSCTGYPKCD 650 >UniRef50_B7KK14 DNA topoisomerase n=4 Tax=Cyanobacteria RepID=B7KK14_CYAP7 Length = 720 Score = 357 bits (917), Expect = 8e-97, Method: Compositional matrix adjust. Identities = 243/735 (33%), Positives = 381/735 (51%), Gaps = 86/735 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGS---AAKKSADSTSTKTAK 57 M K L ++E+P K K + + LGS+Y+VK+S GHIR+L G DS S + Sbjct: 1 MSKKLFLIEAPGKLKKLQQILGSEYIVKASGGHIRELAKDGDDNLGFDLKKDSISCRFM- 59 Query: 58 KPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGE 117 PK P K +S+LK+LA + D + LATD DREGE Sbjct: 60 -PKN-------------------------PMARKTISQLKELARQVDTVILATDEDREGE 93 Query: 118 AIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGY 177 IAWHL+EV+ + + R+ + EIT A++ + N+P L+++ VNA AR +D++VG+ Sbjct: 94 IIAWHLKEVLNLRNPQ--RITYREITPAAVKASLNRPRSLDMNLVNAALARSVLDKLVGF 151 Query: 178 MVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS------------ 225 SPL+WK S GRVQS A+ ++ +REREI+ F P+++W V + Sbjct: 152 RGSPLVWKLGNGAKSIGRVQSAALHILCQREREIQEFKPQDYWLVSVTYSEGFKAYYLGE 211 Query: 226 -TTTPSGEALALQVTHQNDK------PFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 T+TP+ + Q +K + +++ + VSL + + V+E + K + Sbjct: 212 KTSTPTDKEENEQRDDAGEKEENKVEATKVLSEAEADRLVSLARQFPHHVIEVQSKTVSK 271 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY 338 P APF TS+LQQAA +RL + KTM +AQRLYE GYITYMRTDS +L V+ + Sbjct: 272 NPPAPFTTSSLQQAAGSRLKWSPDKTMQVAQRLYEGGYITYMRTDSYHLDPQFCATVKQW 331 Query: 339 ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQ 397 + +P + + + +QEAHEAIRP+D+ + LK ++ A+ +LY LIW + Sbjct: 332 LQQK-DPNNIPVKVASHRTSKTAQEAHEAIRPTDIFKPSIELKQEISAEEFELYLLIWLR 390 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 VA Q A+ T + +GD +ARG+I+ F G+ K L +D +LP V+ G Sbjct: 391 TVASQCKSAQILKTRIITQSGDIFWQARGQIVTFAGYAKYWKDL---SDDLLLPQVSGGQ 447 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L L E + T+PP R+SEA LV+ +E+RGIGRPST+A + T+++RGY +V+ R+ Sbjct: 448 LLNLSEAGHEKKQTQPPPRYSEAKLVQVMERRGIGRPSTFAPTVKTLKERGYAQVQKRQL 507 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL-----DHFFSDFT 572 A +G V L++ EL+ +FTA ME+ LD +A+ + W+ + D+F Sbjct: 508 QATPLGLEVDAFLQKTLPELLQAEFTALMEDKLDAIASGKENWERYIIGWNEDYFAVALL 567 Query: 573 QQLD------KAEKDPEEGGMRPNQMVLTSIDCPTCGRKM-GIRTASTGV----FLGCSG 621 + L + K+ + + + + I+CP C KM I + S + FL C Sbjct: 568 KALKVVGSQASSSKNSQSLEAKGHSNKESKINCPHCSHKMLEIPSKSKKLHKDYFLKCPS 627 Query: 622 YALPPKERCKTTINLVPENEVLNVLEGEDAE--TNALR-AKRRCPKCG--TAMDSYLIDP 676 C+ + ++ L GE ++ T +L+ + CP CG A+ Y + Sbjct: 628 --------CQAVMFYNKWRKIWE-LPGEKSQESTPSLKLTQHSCPVCGEKLAVREYEKEG 678 Query: 677 KRKLHVCGNNPTCDG 691 +K + ++P G Sbjct: 679 VKKQMLVCSSPKAKG 693 >UniRef50_Q3M6J7 DNA topoisomerase n=12 Tax=Cyanobacteria RepID=Q3M6J7_ANAVT Length = 728 Score = 357 bits (915), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 223/652 (34%), Positives = 346/652 (53%), Gaps = 62/652 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSG-SAAKKSADSTSTKTAKKP 59 M K L++VESP K K +++ LGS+++V++S GHIR+L G A S D S + P Sbjct: 1 MPKRLLVVESPGKVKKLSQILGSEWIVRASCGHIRELSDEGEDALGFSMDGGSVQCHYVP 60 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 + D+R ++ + +LK A++ + LATD DREGE I Sbjct: 61 R-DQRS------------------------KETIQQLKSAAKQVSEVVLATDPDREGETI 95 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 AWHL+EV+G + + RVV+ EIT +A++ A P +L+++ V A R +D++VGY Sbjct: 96 AWHLKEVLGLREPK--RVVYTEITASAVQSAIAHPRKLDLNLVGAGLCRDCLDKLVGYKG 153 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SPL+W S GRVQS + L+ +REREI++FVP+++W V V Sbjct: 154 SPLVWALNNGAKSVGRVQSSTLHLICQREREIQSFVPQDYWSVWVDYVEGFRAFYKGAVN 213 Query: 240 HQNDKPFRPVNKEQTQAAVS-----------------LLEKAR---YSVLEREDKPTTSK 279 ++D P V A S L+E+AR + +++ E K + Sbjct: 214 TRSDSPETEVEIHDDAAGNSTTAPESTRVLAEAEANRLVEEARRHPHQIVQYEGKIANRQ 273 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYI 339 P PFITSTLQQAA ++L F +KTM +AQ+LYEAG ITYMRTDS LS + R ++ Sbjct: 274 PPPPFITSTLQQAAGSKLKFAPEKTMQLAQKLYEAGLITYMRTDSVMLSPEFCESARQWL 333 Query: 340 SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQF 398 N + +P+ ++ S + +Q+ HEAIRP+DV + L+ ++ D LY +IW++ Sbjct: 334 EQN-DPQNVPKQVARHRSSKTAQQGHEAIRPTDVFRPSAQLRIELSTDEFNLYVMIWKRA 392 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 +A Q PA+ T + +G +ARG+++ F G+T+ P L K D +LP + +G Sbjct: 393 IASQCRPAQLRKTVVITQSGQILWQARGQVVEFLGYTRYWPNLSK---DTLLPTLQQGQM 449 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFY 518 +TL + T+PP R+SE LV+ +E++GIGRPSTY+ I+T++ RGYV + + Sbjct: 450 VTLENAGHEKKQTQPPPRYSEPKLVQLMERKGIGRPSTYSPTIATLKKRGYVELTKDNLH 509 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD-FTQQLDK 577 +G V L++ +L+ +FTA+MEN+LD +A + W+ L + + F L K Sbjct: 510 PTNLGLEVDTFLQKALPDLLEAEFTAKMENALDAIAEGKQPWQIYLTTWNQNYFAPALAK 569 Query: 578 AEKDPEEGG-----MRPNQMVLTSIDCPTCGR---KMGIRTASTGVFLGCSG 621 A+ + G P Q + CP C K+ FL C+ Sbjct: 570 AKTIAVDSGNPTKTFPPRQYDTSRTRCPDCNNFLSKIPSSKLKKKYFLKCTS 621 >UniRef50_B1VAJ5 DNA topoisomerase n=6 Tax=Acholeplasmataceae RepID=B1VAJ5_PHYAS Length = 655 Score = 351 bits (901), Expect = 6e-95, Method: Compositional matrix adjust. Identities = 224/636 (35%), Positives = 345/636 (54%), Gaps = 65/636 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K ++IVESPAK KT++++ + SS GHIRDL SG Sbjct: 1 MKKKVIIVESPAKIKTLSRFFDDKVEILSSKGHIRDLSLSGK------------------ 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +R+G+D + + YE++ K+ +V L + K I+LATD DREGEAIA Sbjct: 43 --------DRLGIDIKNGFIPKYEIIKEKKTLVESLIK-KTKNKEIFLATDPDREGEAIA 93 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +V+ + +R+VF EITK + +A P ++ V +Q+ RR +DR++G+ +S Sbjct: 94 WHLSKVLNLNPQMANRIVFREITKEVVLKALQNPRTVDELLVFSQETRRMLDRIIGFKLS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 L+ + + SAGRVQSVA++L+V+ E+EI +FVPEE+ + A Q + Sbjct: 154 RLVRR--IKSQSAGRVQSVALKLIVDLEKEINSFVPEEYNLITAFFP-------FFQAEY 204 Query: 241 QNDKPFRPVNKEQTQA-AVSLLEKAR---YSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 QN P NK+ A A+ ++ K + V + + T SKP P ITSTLQQ A Sbjct: 205 QN-----PNNKKIKSAEALGIVAKITNKPFIVKKIKQTETFSKPKKPLITSTLQQEAINN 259 Query: 297 LGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 L +TM +AQ+LYE G ITYMRTDS S+ V + I + +G+KYL Sbjct: 260 LYMTSNQTMRVAQKLYEGIDIEGESIGLITYMRTDSPRFSEVFVKDAQKLIKEKYGQKYL 319 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 + + K +Q+AHEAI+P+D++ ESL ++ KLY LI+++ +A M PA Sbjct: 320 --AVFKQNQKNKAQDAHEAIKPTDLSKTPESLMSYLDKYEYKLYDLIYKRSLASLMKPAI 377 Query: 408 YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 + + G I FDG+ K+ L+ +D+I+P N ++ ++ Sbjct: 378 FQKNQVFFEVEKHSFLTEGLIKTFDGYQKI---LKDNLQDKIIPTFNLNESYFPEKIETF 434 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 Q FT P ARFSEA+L+K LEK IGRPSTY+ II T++ R YV + +RF + G + Sbjct: 435 QKFTTPQARFSEATLIKTLEKLNIGRPSTYSQIIFTLKKRFYVDMIEKRFQPTEQGILTI 494 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 LE F++ ++Y +TAQME+ LD++A+ + K ++ F+++F Q A++ E+ + Sbjct: 495 QNLELFFKQFLDYQYTAQMESDLDKIASGLVDNKQLMQTFYTNFLQLYQIADQKLEK--I 552 Query: 588 RPNQMVLTSIDCPTCGR-KMGIRTASTGVFLGCSGY 622 +P + T C C + I+ + G FLGCS + Sbjct: 553 KP---IETDQKCNLCNEGNLLIKKSHYGSFLGCSRF 585 >UniRef50_B5TTQ4 TraB n=3 Tax=environmental samples RepID=B5TTQ4_9BACT Length = 750 Score = 350 bits (897), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 245/787 (31%), Positives = 388/787 (49%), Gaps = 119/787 (15%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP K I +LGSD+ V +SVGH+RDLP G Sbjct: 3 LVIVESPNKCSKIGSFLGSDFKVVASVGHVRDLPRKG----------------------- 39 Query: 65 GALVNRMGVDPWHNWEAHYEVLP----------GKEKVVSELKQLAEKADHIYLATDLDR 114 +G+D +++ Y +P G EK + ++K KAD IYLATD DR Sbjct: 40 ------LGIDIANDFAMEYSFIPDAKVNDRTFDGGEKRIEKIKAFLNKADKIYLATDPDR 93 Query: 115 EGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 EGEAI+WHL+E +G +D ++ R+ FNEI++ AI++A N L+ V AQ+ARR +DR+ Sbjct: 94 EGEAISWHLKECLGLEDGQFERIEFNEISEKAIKEAINNGRGLDYQLVYAQEARRALDRL 153 Query: 175 VGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEAL 234 VGY+VSP+ + + SAGRVQS AV +VV RE EI+ F + V+ S + + Sbjct: 154 VGYLVSPMASNLMGQPSSAGRVQSPAVLIVVLREIEIQKFKVTNHFGVNLSFDKEPKKWI 213 Query: 235 ALQVTHQ---NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + VT + D+P+ V V+ +K + VL +K S +PF T+ L Q Sbjct: 214 SQWVTTEFVTEDQPY--VLDRSLAEEVAKTKKVK--VLNCTEKTEYSNAPSPFSTALLLQ 269 Query: 292 AASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 AAS LGF ++T AQ L+E G ITY+RTD N++ ++V + Y +++ + LPE Sbjct: 270 AASVALGFSPQQTTKAAQALFEQGAITYIRTDGLNIADESVEEIFAYANEH--QFSLPEK 327 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 PN++ K+ +Q AHEAIRP V++ + L + + LYQLIW + ++ Q+ A+Y + Sbjct: 328 PNKFKEKDGAQNAHEAIRP--VHITDKDL-GKSPEQKALYQLIWERTISSQLAKAEYKAV 384 Query: 412 TLTVGA--GDFRLKARGRILRFDGWTKVMPALRKGDEDR---ILPAVNKGDALTLVELTP 466 TL + + G ++ A+ R L GW DE+ ++P + G + + Sbjct: 385 TLELLSEDGKYKFHAKSRELIKKGWMVFGKDCLNEDENEPSGVVPVLEVGSVVDVESGEV 444 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 TKPP R++EASL+K+LE GIGRPSTY+SI++ I ++G++ VE + K+G + Sbjct: 445 IAKQTKPPKRYTEASLIKKLESCGIGRPSTYSSIMANILNKGFLEVEKKVLKPTKLGNDL 504 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG 586 L + ++ ++ +ME LD++A+ E + +V+ ++ Q+L A K Sbjct: 505 IGSLLKAKFSFLDLHYSKEMELQLDKIASGETSYNSVVSALYTQLAQELSTASK------ 558 Query: 587 MRPNQMVLTSIDCPTCGRKMG--IRTASTGVFLGCSGYALPPKERCKTTIN--------- 635 + +I CP C ++ T + F CS E CK ++N Sbjct: 559 ----LTAINAIPCPKCKSQLKKFKNTKTNQFFWICSN------EDCKHSMNDDKGKPVEK 608 Query: 636 ---LVPENEVLNVLEGEDAETNAL----------------------RAKRRCPKCGTAMD 670 P+ + + + ++++T + K CPKC T + Sbjct: 609 VIHSCPKCKTGRLNKFQNSQTKEFFWICNDQECKHSMDDKKGQPVEKIKYPCPKCSTPLF 668 Query: 671 SYLIDPKRKLHVCGNNPT-CDGYEIEEGEFRIKGYDGPIVE---CEKCGSEMHLKMGRFG 726 + K + C N T C + E + P++E C +C S++ G G Sbjct: 669 RSKKEGKDPIWFCPNRETDCKVFLPEVNK-------KPLLEVYSCPQCASDLRRINGANG 721 Query: 727 KYMACTN 733 + CTN Sbjct: 722 YFWGCTN 728 >UniRef50_C1MSJ2 DNA topoisomerase n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MSJ2_9CHLO Length = 1243 Score = 343 bits (879), Expect = 2e-92, Method: Compositional matrix adjust. Identities = 252/758 (33%), Positives = 367/758 (48%), Gaps = 136/758 (17%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 + LVIVESPAKA ++ KYLG Y V +S GH+RDL + Sbjct: 98 RTLVIVESPAKATSVQKYLGQSYQVLASYGHVRDL-----------------------VE 134 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK-ADHIYLATDLDREGEAIAW 121 ++G+++ G W L GK VV + + AE+ + LATD DREGEAIAW Sbjct: 135 KQGSVLPDDGFA--MRWS-----LQGKSGVVKSIVESAERCGGGVVLATDPDREGEAIAW 187 Query: 122 HLREVIGGDDAR--------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 H+ E++ +R SRV F E+T++A+ +AF +P E++++ V+A ARR +D Sbjct: 188 HISELLKERGSRKKKDAPTAISRVTFTEVTRDAVVKAFKEPREISVELVHAYLARRALDY 247 Query: 174 VVGYMVSPLLWKKI--ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 + G+ +S +LW+KI + LSAGRVQS A+RL+ ERE I+ V EE+W V A SG Sbjct: 248 LFGFKLSGVLWRKIPSSERLSAGRVQSAALRLICEREMSIERHVKEEYWSVVAGLERASG 307 Query: 232 --------EALALQVTHQNDKPFR----PVNKEQTQAAVS---LLEKARYSVLEREDKPT 276 + H++ R VN +Q AVS L K V E+K Sbjct: 308 VKKSDGDASGRFVAELHRDASGARLAKGAVNSKQIAEAVSNEILAAKDTLYVATVEEKEA 367 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-----GYITYMRTDSTNLSQDA 331 T+KP PF TSTLQQ A+ +LGFG +TM AQ+LYE G ITYMRTD ++ DA Sbjct: 368 TTKPKPPFTTSTLQQEANAKLGFGSARTMSAAQKLYEGKGFGEGLITYMRTDGLHVGPDA 427 Query: 332 VNMVRGYISDNFGKKYLPESPNQY-ASKENSQEAHEAIRPSDVNVMAESLK---DMEADA 387 V +R ++ FG Y+P +PN Y +++N+QEAHEAIRP ++ ++ +D Sbjct: 428 VKAIRAVATEEFGASYVPATPNAYKKTQKNAQEAHEAIRPIRAELLPNAVSARLGANSDE 487 Query: 388 QKLYQLIWRQFVACQMTPAKYDSTTLTVGAG----DFRLKARGRILRFDGWTKVMP--AL 441 +LY+LIW + +A QM+ A V + + LKA G L F G+ Sbjct: 488 ARLYKLIWSRTMASQMSRAVTRRIAAEVKSASEGCELALKANGSRLLFSGFLAAYAHGGR 547 Query: 442 RKGDEDR-----ILPAVNKGDALTL----------------------------------- 461 GD+DR LP + GD + L Sbjct: 548 TSGDDDRDKRDAWLPELKPGDTINLRAPQSVRVIERDKDAKRGGLAKKKSDQADDEDAVD 607 Query: 462 -----------VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 +T QH+T+PPAR++E +LV+ +E++GIGRPSTYASI+ + RGYV Sbjct: 608 VSETLSSVDTSAGITALQHWTQPPARYTEGALVRAMEEKGIGRPSTYASIVKVMLKRGYV 667 Query: 511 RVENRR--FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 + E G +V+ L F E ++Y FTA +E+ LD +A+ +AEWK V+ F+ Sbjct: 668 VGGGGKGPLIPETRGRMVSSFLTHFFDEYVDYGFTAGLEDKLDDIASGDAEWKDVMSKFW 727 Query: 569 SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL-GCSGYALPPK 627 F + + +R +V+ +D G + T L + A PP+ Sbjct: 728 KPFHGDVQGLQN------IR-TSLVVDVLDATLGAHFFGDDESETKARLDAIAATAEPPR 780 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKC 665 + + + D + LRA RRCP C Sbjct: 781 SEG----DAAAPKRAGDAWKSPDYDPATLRASRRCPAC 814 >UniRef50_A8II62 DNA topoisomerase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8II62_CHLRE Length = 772 Score = 342 bits (878), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 242/691 (35%), Positives = 342/691 (49%), Gaps = 112/691 (16%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +V+VESP KAK I +LG Y V +S GH+RDLP +A + + + Sbjct: 1 VVVVESPTKAKKIQGFLGDKYKVLASYGHVRDLPPKAGSAAAAGVAGEEE---------- 50 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH-- 122 +W ++VL ++E+ A A + LATD DREGEAI+WH Sbjct: 51 -------------DWYLDWQVLDVARPRMAEIAGAATGAPLLVLATDPDREGEAISWHIS 97 Query: 123 --------LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 LR+V G R+ F EITK+A+ A +++ V+A +ARR +D + Sbjct: 98 QELEKRGVLRKVGG-----VQRITFTEITKSAVTNALAAGRQVSQPLVDAYRARRALDYL 152 Query: 175 VGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA---------- 224 VG+ +SP+LW+K+ SAGRVQSVA+RLV ERE I+AF P +W + A Sbjct: 153 VGFQLSPVLWRKLPGARSAGRVQSVALRLVCEREAAIEAFNPLAYWSIAAMLAPPSRGAA 212 Query: 225 -----STTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSL---LEKARYSVLEREDKPT 276 + P+ + ++TH + + ++ A L ++ +V + Sbjct: 213 AAAAAAAAGPTAALIRSRLTHADGRRLGGMDIRSQAEAEELARRIQSGPVTVARVVVRQQ 272 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-------GYITYMRTDSTNLSQ 329 PGAPF TSTLQQ AS RLGF +TM +AQ+LYE G ITYMRTD ++S Sbjct: 273 QRHPGAPFTTSTLQQEASRRLGFSAARTMRVAQQLYEGAGVCTGEGLITYMRTDGVSISA 332 Query: 330 DAVNMVRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPS-DVNVMAESL-KDMEAD 386 +AV +R + FG+ +P P Y S+ +N+QEAHEAIRP+ V SL ++ D Sbjct: 333 EAVAELRAANAAMFGRGCVPPQPRWYKSRAKNAQEAHEAIRPTRPAAVTPSSLPAALDPD 392 Query: 387 AQKLYQLIWRQFVACQMTPAKYD--STTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG 444 LY LIWR+ VA QMT A YD S G L+A GR+LR G+ LR Sbjct: 393 QAALYDLIWRRAVASQMTSAAYDVVSVEFEADGGRLGLRASGRVLRDPGY------LRAY 446 Query: 445 DEDRILPAV-------------------NKGDALTLVELTPAQHFTKPPARFSEASLVKE 485 ++D + L +L QH T+PP RF+EASLV+ Sbjct: 447 NDDEPAEGEEPAPEAEAAGGGEDEGAAARENQGLAAQQLLALQHATRPPPRFTEASLVRA 506 Query: 486 LEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQ 545 LE+RGIGRPSTYA I++ +QDRGYV E R +G ++T LE F ++YDFT+ Sbjct: 507 LEERGIGRPSTYAPIMTLLQDRGYVCREGRALLPTSLGRVLTSFLEHYFATWVDYDFTSD 566 Query: 546 MENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID------- 598 ME LD VA+ +A W+ VL F+ F + +R Q Sbjct: 567 MEGRLDDVASGKAAWRRVLSAFWGPFQAAVGSM------AAIRTTQPPGAPGAAAGPAPQ 620 Query: 599 -----CPTCG-RKMGIRTASTGVFLGCSGYA 623 CP CG ++ ++ + G F+GCS +A Sbjct: 621 RDPRRCPKCGVGRLVLKPSRYGGFIGCSNFA 651 >UniRef50_A4BJY7 Topoisomerase I n=1 Tax=Reinekea blandensis MED297 RepID=A4BJY7_9GAMM Length = 713 Score = 341 bits (875), Expect = 6e-92, Method: Compositional matrix adjust. Identities = 226/562 (40%), Positives = 309/562 (54%), Gaps = 61/562 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+IVESP K K I +YLG+ ++VK+SVGHIRDLP +KD Sbjct: 3 LMIVESPNKCKKIAEYLGAGWMVKASVGHIRDLP---------------------QKD-- 39 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +GVD + + Y + GK KVV +L+ A KAD ++LATD DREGEAIA+H+R Sbjct: 40 ------LGVDVENRFRPAYVISEGKHKVVKDLQAAAAKADEVWLATDPDREGEAIAYHIR 93 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 V+G D Y RV FNEI K +I++A P +LN+ V AQ+ RR +DR+VGY VSP L Sbjct: 94 TVLGLKD-NYKRVTFNEINKGSIQKALASPRKLNMQMVAAQETRRILDRLVGYTVSPALQ 152 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDK 244 + + G+SAGRVQS AVRLVV+REREI+ F P++ + A T +G + L + K Sbjct: 153 AQSSAGMSAGRVQSPAVRLVVDREREIQGFTPQDHYT--AVITLDNGLEMKL-----DTK 205 Query: 245 PFRPVNKEQTQAAV--SLLEKARYSVLER-EDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 P + T A+ ++L ++ + +P P F TS LQQ AST+LG Sbjct: 206 PLQNAEGLVTDPAIIDAILHPLSDVIITKAATEPKQVNPKPVFTTSELQQVASTKLGLSP 265 Query: 302 KKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENS 361 +TM AQ L+EAG ITY RTD NLS D M+ Y+ G PE A N+ Sbjct: 266 DQTMKQAQSLFEAGRITYHRTDDPNLSDDGWAMIAAYLESQ-GIPVSPERRKWKAKDANA 324 Query: 362 QEAHEAIRPSDVNVMAESLKDM--EADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD 419 QEAHE IRP+ S+ D + D +LY+LI+ + +A +T D +T + Sbjct: 325 QEAHEGIRPT-------SMTDEPGQGDTDQLYRLIYERAMAA-VTVNGVDISTQVIAKAT 376 Query: 420 FRL------KARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL-TPAQHFTK 472 L KA G+++ GW ++M +D L V D + V + T Sbjct: 377 LDLDVPVEFKASGKVVETMGWRQLMTIEVAESKDTQLKCVPDVDQVCAVAAKSRKDQVTT 436 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRLE 531 PPAR++EASLVKELEKRGIGRPSTYA+I + R Y+ V + R+ +G V D L Sbjct: 437 PPARYTEASLVKELEKRGIGRPSTYATIFVNVFRRQYLEVGKGRQITPTPLGVAVVDALM 496 Query: 532 ENFRELMNYDFTAQMENSLDQV 553 E M+YD+TA +E+ LDQ+ Sbjct: 497 S--MEFMDYDYTANLESQLDQM 516 >UniRef50_Q9PHK2 DNA topoisomerase I, plasmid n=3 Tax=Gammaproteobacteria RepID=TOP1P_XYLFA Length = 660 Score = 341 bits (875), Expect = 7e-92, Method: Compositional matrix adjust. Identities = 232/647 (35%), Positives = 339/647 (52%), Gaps = 92/647 (14%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+I+ESP K + ++ LG + + +SVGH+RDLP Sbjct: 3 LMIIESPGKIEKLSTILGDGWKIAASVGHVRDLPQ------------------------- 37 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 MGV +++ YE+ E VV++LK L ++AD +YLATD DREGEAI+WHL+ Sbjct: 38 ----KEMGVAA-PDFKPSYELTERGEGVVAKLKNLLKQADSVYLATDPDREGEAISWHLQ 92 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 + + + RV FNEIT NA++ + P +++ RV AQ+ARR +DR+VGYMVSP L Sbjct: 93 QCLKLSNPL--RVTFNEITANAVKASLVAPRTIDVKRVAAQEARRVLDRLVGYMVSPELS 150 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAF-VPEEF----WEVDASTTTPSGEALALQVT 239 + + LSAGRVQS AVRLVVEREREIKAF V F + DA T SGE A +T Sbjct: 151 RLTGKRLSAGRVQSPAVRLVVEREREIKAFKVTNHFGAMLFFADAKT---SGEWSAEWLT 207 Query: 240 H----QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 D P+ ++++ A + S E E K P PF TST+QQAAS Sbjct: 208 KPKFVAEDNPYF-MDRDFAAAVAQVKAVVVKSFDESEAK---RSPPPPFTTSTMQQAASV 263 Query: 296 RLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQY 355 LG K M AQ+LYE G+ITY RTD+ N+S +++ + +S G + E P ++ Sbjct: 264 TLGVDPKAAMDAAQKLYEQGHITYHRTDNPNVSDESLGDIYA-VSVKLGLD-IAEKPRKF 321 Query: 356 ASKENSQEAHEAIRPS--DVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 + +Q H A+ P+ +V E+ +D + LY+LI + +ACQ+ A+Y T+ Sbjct: 322 KAPAGAQVGHPAVTPTHWEVEEAGET-----SDQKALYKLIRLRAIACQLADARYAVRTV 376 Query: 414 ------TVGAGDFRLKARGRILRFDGWTKVMPALRKGDED-------RILPAVNKGDALT 460 VG + +ARGR L + GW K++ + +ED +P G+ L Sbjct: 377 RLEAAQPVGGKNVEFEARGRTLIYQGWLKLIAGDQTEEEDGNEKESSNPIPVCAPGECLD 436 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 + + TKPP+ +++A+LVK+LE GIGRP+TYA+I+ I RGYV+ E + + Sbjct: 437 VARGKLLEKKTKPPSHYTQATLVKKLESEGIGRPATYAAIMDNIVSRGYVKTEKKYLFPT 496 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF-----TQQL 575 + GE++ D L F E ++ FT ++E SLD++A E+ +KAV+ T Q+ Sbjct: 497 ETGELIVDSLVGKF-EFLDLGFTREIEESLDRIAQGESGYKAVIAKVHDQLNMELSTLQV 555 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGY 622 K P C CG+ + G F GCSGY Sbjct: 556 SATPKHP----------------CQECGKPLRRIPGKNGHFWGCSGY 586 >UniRef50_B7GCB2 DNA topoisomerase (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7GCB2_PHATR Length = 520 Score = 341 bits (874), Expect = 8e-92, Method: Compositional matrix adjust. Identities = 210/539 (38%), Positives = 310/539 (57%), Gaps = 52/539 (9%) Query: 5 LVIVESPAKAKTINKYLGS---------DYVVKSSVGHIRDLPTSGSAAKKSADSTSTKT 55 LVIVESP+K +TI K L + D+ V SS+GHIR+LP S ++ KK + Sbjct: 1 LVIVESPSKCQTIAKILATYVKDNSLAYDFQVSSSMGHIRNLPKSDTSKKKKENQI---- 56 Query: 56 AKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDRE 115 KP + G+D + ++ Y +LPGK +V EL+ LA A+ + LATD DRE Sbjct: 57 --KPNGKFPYTIA---GIDLENGYQPEYVLLPGKGPLVKELQHLAANAELVLLATDPDRE 111 Query: 116 GEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 GEAIAWHL +V+ +RY RV F EIT + I +A P ELN + V+AQ+ RR +DR+ Sbjct: 112 GEAIAWHLTQVLDLAPSRYQRVTFTEITPSRILEAVKSPVELNTNLVHAQETRRVLDRLA 171 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT---TPSGE 232 GY VSP+LWKKIA GLSAGRVQSV + +VV+RERE F +W + A +P G+ Sbjct: 172 GYTVSPVLWKKIAPGLSAGRVQSVGMAMVVQRERERLCFETTPYWNIKAVLGKDFSPQGQ 231 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 L +H+ R + + V +L A ++V++ + +P PF TSTLQQ Sbjct: 232 ILRPGSSHK-----RHLLEGDANELVKVLSDAEFTVIQVKSTTRKQQPPQPFKTSTLQQE 286 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFG--KKYLPE 350 A+ RLG V++TM +AQ+LYE G I+YMRTDST+LS DA + + FG + ++ Sbjct: 287 ANRRLGMAVQQTMRVAQQLYEEGLISYMRTDSTHLSDDAECAIGVSVRGQFGPDRLWVGS 346 Query: 351 SPNQYASKEN--SQEAHEAIRPS--------DVNVMAESLKDMEADAQKLYQLIWRQFVA 400 S + K++ +QEAHEAIRP+ + + + + + A++LY +I+++ +A Sbjct: 347 SKTKRKPKDSKFAQEAHEAIRPALQPDGIFLEPRYLLQKVA-LSDQAERLYTMIYQRTLA 405 Query: 401 CQMTPAKYDSTTLTVGA------GDFRLKARGRILRFDGWTKVMPALRKGDEDR---ILP 451 C+M P + T++ + FR+ G ++ G+T + R +E+ LP Sbjct: 406 CRMPPIATNQTSVLIAGVQEGTTAHFRVS--GSVVIDPGYT--LAYCRDAEEENDEAYLP 461 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 A+ +G L E+ H T+PP R++EAS VKELE G+GRPSTY+ I+ ++DR YV Sbjct: 462 ALREGQILNAGEILAVAHETQPPPRYNEASFVKELESLGVGRPSTYSGIVQILRDRAYV 520 >UniRef50_O51768 DNA topoisomerase 1 n=22 Tax=Borrelia RepID=TOP1_BORBU Length = 848 Score = 341 bits (874), Expect = 8e-92, Method: Compositional matrix adjust. Identities = 207/591 (35%), Positives = 333/591 (56%), Gaps = 43/591 (7%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K L+IVESP KAKTI K+L ++V++ +GH+ DLP + PK+ Sbjct: 3 NKKLIIVESPTKAKTIKKFLDESFLVEACIGHVVDLPNNAKEI--------------PKE 48 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++ N + +D + + Y + K+ +VS+LK+L + + IYLATD DREGE IA+ Sbjct: 49 YKKYEWAN-ISIDYNNGFNPIYIIPSNKKPIVSKLKKLVKTINEIYLATDQDREGETIAF 107 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL+EV+ + Y R++F+EIT+ AI ++ ++++ VNA +ARR +DR+ GY +SP Sbjct: 108 HLKEVLKIKN--YKRMIFHEITETAITESLKNTRNIDMNLVNAGEARRILDRLYGYTISP 165 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV-------------DASTTT 228 LLWKK+A GLSAGRVQSV ++L++E+E+ F ++ + +A Sbjct: 166 LLWKKVAYGLSAGRVQSVGLKLLIEKEKTRINFKKANYYSILLQCKHEKKNLLLEAKLEE 225 Query: 229 PSGEALALQVTHQNDK-PFRPVNKEQ--TQAAVSLLEK-----ARYSVLEREDKPTTSKP 280 G+ +A N+ + + K TQ + LEK + ++ E K P Sbjct: 226 IDGKNIAEGKDFVNETGKLKNIAKTTIITQDLMIELEKELKNGQKIELISIETKKIKIPP 285 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS 340 PF TSTLQQ + RL G K+ M AQ+LYE GYITYMRTDS N+++ A + + I Sbjct: 286 PKPFTTSTLQQEINKRLKIGTKQIMQHAQKLYEHGYITYMRTDSHNIAKIAKDKITKIIK 345 Query: 341 DNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 + +GK+Y+ E Y ++ +Q AHEAIRPS++ + E+++ A+++Y++IW + + Sbjct: 346 NKYGKEYIEEKDRIYEKEKMAQNAHEAIRPSEIFIPNETIEIESKTAKEIYKIIWDRTII 405 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE--DRILPAVNKGDA 458 M A ++ LT + ++ + FDG+ K ++ DE + + KGD Sbjct: 406 SGMKDAIKENIKLTFKYKNLIFRSSFTKIIFDGFLK---HTKEQDEHLNINFDLIKKGDT 462 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFY 518 ++V++ ++H TK P R++EASLV+++EK GIGRPSTY++IIST+ +R Y N Sbjct: 463 FSIVKMKTSEHETKAPFRYTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNNTLM 522 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 G V + LE+ F L+ +FT+ ME LD++A + + L F++ Sbjct: 523 PTIKGAAVINLLEKYFPVLIELNFTSNMEEKLDKIAIGKLDKIKYLSKFYN 573 >UniRef50_Q8EVZ3 DNA topoisomerase n=1 Tax=Mycoplasma penetrans RepID=Q8EVZ3_MYCPE Length = 707 Score = 340 bits (873), Expect = 1e-91, Method: Compositional matrix adjust. Identities = 228/649 (35%), Positives = 353/649 (54%), Gaps = 63/649 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+I+ESP K KT+ KYLG DY + +++GHIRDL G AD KK+ + Sbjct: 4 LLIIESPNKIKTLTKYLGKDYEIIATIGHIRDLNQFGMGF--DADFEPKWVIPSVKKNSK 61 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 N+ V K+++V +LK+ A KA IY+ATD DREGEAIAWH+ Sbjct: 62 ----NKNEV--------------SKKEIVEKLKKSASKAKEIYIATDPDREGEAIAWHVY 103 Query: 125 EVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 EV+ + R+ FNEITKNAI ++ N +++I+ V +Q ARR +DR++G+ +S LL Sbjct: 104 EVLDAASQKKCKRITFNEITKNAILESLNHKRDIDINWVQSQFARRIIDRLIGFKLSKLL 163 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 K+ + SAGRVQSVA++ + +RE+EI+ FV E +W +D +L L+ N Sbjct: 164 QTKL-KADSAGRVQSVALKFIEDREKEIRNFVAENWWTLDV--MLEDNNSLILKSIDPNL 220 Query: 244 KPFRPVNKEQTQAAVSLL-EKARYSVLEREDK---------PT--TSKPGAPFITSTLQQ 291 K + K+ + + + + E++ ++L DK P+ +S P +P+ TSTLQQ Sbjct: 221 KNIKLSEKKFSTSGLDIADEESANNLLNALDKKFKVKSIEEPSFYSSYPKSPYKTSTLQQ 280 Query: 292 AASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNF 343 A +LG+ KK ++AQ LYE I+Y RTDS LS V +I + + Sbjct: 281 DAINKLGWNSKKITLIAQHLYEGVEVDGNQIALISYPRTDSLRLSDTFVQSAFKFIEETY 340 Query: 344 GKKYLPE-SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 GK Y+ + A+ N+Q+AHEAIRP D + + LK+ + D LYQLI+ + VA Sbjct: 341 GKDYVGKYQVKSSANDANTQDAHEAIRPIDPYLTPQELKNKISKDEFALYQLIYNRTVAS 400 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNK--GDAL 459 M AK+ T+ + R F G+ K+ + +E++++ N G Sbjct: 401 LMAAAKFKKVTIKFDNNNCEFYTFSRECLFLGFKKLYVEDNEDEENKLIDLNNYPVGKEF 460 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 + +H T+PP R+++A+L+ +LE G+GRPSTY+S+ + +RGY + + + Sbjct: 461 KSKVMEVKKHETQPPQRYTQATLIGDLESAGVGRPSTYSSMANIALERGYAVTDKKAYVM 520 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA- 578 +G+IV D+LE+ F +++N DFT +ME LDQ+A+ EWK+ L F F +++ KA Sbjct: 521 TDIGKIVVDQLEKFFPDIINKDFTKKMEEHLDQIASGNEEWKSWLKKFAPGFDEEVKKAY 580 Query: 579 ---EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG--VFLGCSGY 622 EK +E R +CP CG+ + + A G F+GCSGY Sbjct: 581 DTMEKISDEKVGR---------ECPKCGKDLLYKRARRGGSKFIGCSGY 620 >UniRef50_A3BAP2 DNA topoisomerase n=6 Tax=Poaceae RepID=A3BAP2_ORYSJ Length = 1180 Score = 339 bits (870), Expect = 3e-91, Method: Compositional matrix adjust. Identities = 240/740 (32%), Positives = 367/740 (49%), Gaps = 145/740 (19%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K++++VES KAK I KYLG Y V S GH+RDL +K + Sbjct: 295 AKSVLVVESVTKAKVIQKYLGDMYEVLPSYGHVRDL---------------AGRSKSVRP 339 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 D+ ++V + W + ++ L G + V A+++ LA+D DREGEAIAW Sbjct: 340 DDDFSMVWEVPAAAWTHLKSIRTALKGYDNAVW--------AENLILASDPDREGEAIAW 391 Query: 122 HLREVIGGDDARYS-----RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 H++E++ DA S RVVF+EIT++A+++A P +++D VNA ARR +D ++G Sbjct: 392 HIKEMLEQQDALGSKVTVARVVFHEITEDAVKKALISPRYIDMDLVNAYLARRSLDYLIG 451 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT----PS-G 231 + +SPLLW+K+ SAGRVQS A+ LV +RE EI+ F P+E+W VD T PS G Sbjct: 452 FGISPLLWRKLPGCQSAGRVQSAALALVCDREAEIEQFDPQEYWTVDTDFKTQHSGPSNG 511 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSL---LEKARYSVLEREDKPTTSKPGAPFITST 288 L ++ H N K ++ + A ++ + +++ V + P P+ITS+ Sbjct: 512 LNLQSRIKHLNSKKLDQLSIRSQEEAHNIEKRIYSSQFEVTGIKRSKINKNPPMPYITSS 571 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDA-------V 332 LQQ A+ +L F TM +AQ+LYE G ITY+RTD + Q A Sbjct: 572 LQQDAANKLHFSAGYTMKVAQKLYEGINLSSEEATGLITYIRTDGFHWYQSARGQCVFLC 631 Query: 333 NMVRG----------------------------------YISDN------------FGKK 346 + VRG +ISD +G++ Sbjct: 632 SRVRGGIEEALACLACEQLSAAQATIIAAHDNRIVANSIFISDGAAEDILSLVKQRYGEE 691 Query: 347 YLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMT 404 Y E +Y K +N+QEAHEAIRP+ + + SL ++ D+ KLY LIW++ +ACQM Sbjct: 692 YASEGIRKYFKKVKNAQEAHEAIRPTSIRRLPSSLVGALDDDSLKLYTLIWKRTMACQME 751 Query: 405 PAKYDSTTLTVG--AGDFRLKARGRILRFDGW------TKVMPALRKGDEDRI------- 449 ++ D + +G GD + L F G+ T+ P+ + D + Sbjct: 752 ASRTDMIQVDIGNSEGDMIFHSSASRLDFKGYQAVYDDTEASPSSYNSEVDAVHQDNFEA 811 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 L + D ++ V + +QHFTKPP+R+SE++L+K+LE+ GIGRPSTYASI+ +QDR Y Sbjct: 812 LSKLEVKDLVSPVNVHLSQHFTKPPSRYSESALIKKLEELGIGRPSTYASIMKVLQDRKY 871 Query: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 V +++R + E G +V+ L +F E+ + FTA ME LD V+ EWK +L F+ Sbjct: 872 VTIKSRVLHPEFRGRMVSAFLMHHFSEVADLSFTANMETELDNVSAGSTEWKGLLKDFWE 931 Query: 570 DFTQ------QLD-------------------KAEKDPEE--GGMRPNQMVLTSIDCPTC 602 F + +LD K E+ EE G + + + S CP+C Sbjct: 932 RFNKYCGDASRLDVRKVERKSLLISHKVQLPLKVERMLEEKFGSILFSDLDNDSRICPSC 991 Query: 603 GR---KMGIRTASTGVFLGC 619 + + G F+GC Sbjct: 992 SEGTLRFKVSRYGEGYFIGC 1011 >UniRef50_B2V7T0 DNA topoisomerase I n=5 Tax=Aquificales RepID=B2V7T0_SULSY Length = 683 Score = 339 bits (869), Expect = 3e-91, Method: Compositional matrix adjust. Identities = 220/586 (37%), Positives = 321/586 (54%), Gaps = 55/586 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K +VIVESP KAK I+ +LG D++VK++VGH +DLP Sbjct: 4 KKIVIVESPKKAKEISHFLGKDFIVKATVGHFKDLPE----------------------- 40 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLP-GKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 N MGVD + +E + + +K++SE+K+LAEK++ + +ATD DREG AI + Sbjct: 41 ------NEMGVD-LNTYEPKFVIKSQNHKKILSEIKKLAEKSE-VIIATDPDREGYAIGF 92 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGE-LNIDRVNAQQARRFMDRVVGYM 178 + E + R F+EITK I++ P E N NA RR DR+VGY Sbjct: 93 FMYEELKKKAKEVKRAEFHEITKEHIKEKIKNAVPFEKTNFGLFNAFLGRRVGDRIVGYT 152 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST-TTPSGEALALQ 237 +SP+ ++I S GRVQS AVRL+VERE EI+ F P ++ + A T L Sbjct: 153 LSPIASREIGGRFSVGRVQSPAVRLIVEREIEIQNFKPTPYYVLSAVLRATSHVSPLTFT 212 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARY-SVLEREDKPTTSKPGAPFITSTLQQAASTR 296 ++N K NKE+ + + ++ + ++ + E K P PF TSTLQQ AST Sbjct: 213 AIYENPK---IENKEEAEKIYADIKDEKIATIKKVEKKQVKQSPKPPFTTSTLQQTASTV 269 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 F +KTMM+AQ L+E+G ITY RTDS +S+ A++ +R I+ FGK YLPE Y Sbjct: 270 YRFAPEKTMMLAQDLFESGLITYHRTDSVRISEKAIDGIRNLINKEFGKDYLPEKIRVYK 329 Query: 357 SKENSQEAHEAIRPSDVNVMAESL-----KDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 SK +AHEAIR + + E K + D KL +LI+ + VA QM A ++ T Sbjct: 330 SKNTQADAHEAIRITHFVNLEEQKKLIKEKGLSEDHFKLLKLIYERTVASQMADAIFERT 389 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKV--MPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 + V + KA G IL+F G+ V + +E++ LP + D LTL ++ + Sbjct: 390 SAAVDIKGYTFKASGSILKFKGYKAVYDLEEEEDKEENQKLPDLKNKDVLTLEKINLEEK 449 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FTKPPAR++E LVK+LE+ GIGRPSTYA+II TI++RGYV EN + + + Sbjct: 450 FTKPPARYTEGGLVKKLEELGIGRPSTYATIIKTIKERGYVVKENGSLRPTENAFHLIEY 509 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 L + +++Y FT +ME+ LD+V ++ +WK +F +QL Sbjct: 510 LNTRYNWVIDYSFTKKMEDFLDKVEENKKDWK--------EFVKQL 547 >UniRef50_Q5UQB5 DNA topoisomerase 1 type prokaryotic n=1 Tax=Acanthamoeba polyphaga mimivirus RepID=TOP1P_MIMIV Length = 854 Score = 335 bits (858), Expect = 5e-90, Method: Compositional matrix adjust. Identities = 225/652 (34%), Positives = 334/652 (51%), Gaps = 116/652 (17%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+++ESP K I+ LG +YVVK+S+GH RDL PKK Sbjct: 4 LILLESPGKISKISSILGKNYVVKASMGHFRDL--------------------DPKK--- 40 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 M +D +++E Y V K VV LK + D +YLA D DREGEAIA L Sbjct: 41 ------MSIDFDNDFEPVYIV--TKPDVVKNLKSAMKNIDLVYLAADEDREGEAIAQSLY 92 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 +V+ + Y R+ FN ITK+AI A G+++ + V+AQ+ARR +DR+ GY++SP+L Sbjct: 93 DVLKP--SNYKRLRFNAITKDAIMSAIKNAGDIDKNLVDAQKARRVLDRLFGYLISPILQ 150 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT-HQND 243 ++I LSAGRVQSV VR+++++E EIK F+ + D+S SG + T H+++ Sbjct: 151 RQIGGKLSAGRVQSVTVRIIIDKENEIKNFINK---NADSSYFKVSGTFNGAKATLHESN 207 Query: 244 --KPF-------------RPVNKEQTQA-AVSLLE---KARYSVLEREDKPTTSKPGAPF 284 KPF +N E + V+ ++ K+++ + EDK TT P PF Sbjct: 208 DKKPFDLETAYKGKTAQIALINSENPNSKVVNFMKRCLKSQFFIHSVEDKMTTRSPAPPF 267 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFG 344 TSTLQQ A+ + G + TM AQ+LYE GYITYMRTDS +S + ++ I+D +G Sbjct: 268 TTSTLQQEANRKFGMSIDSTMKTAQKLYEGGYITYMRTDSVEISAEGHRDIKKIITDQYG 327 Query: 345 KKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQM 403 Y + N Y +K NSQEAHEAIRP+ ++ + +A KLY+LIW++ +A QM Sbjct: 328 ADYYQK--NLYKNKAANSQEAHEAIRPTHPELLTLEGEIEDAYQIKLYKLIWQRTIASQM 385 Query: 404 TPAKYDSTTLTVGAGD---------FRLKARGRILRFDGWTKV-MPALRKGDEDRI---- 449 PAK T + + + +++ + F G+ KV + ++ D D Sbjct: 386 KPAKIKVTIIQISISKYVEDKLNPFYYFQSQIETVVFPGFMKVYVESIDDPDTDNQITKN 445 Query: 450 ----LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQ 505 +P V G +T+ E+ Q + +PP R+SEASLVK+LE+ GIGRPSTY + I TI Sbjct: 446 FTGKIPTV--GSKVTMEEIIARQEYMRPPPRYSEASLVKKLEELGIGRPSTYVNTIKTII 503 Query: 506 DRGYVRV-------------------------------------ENRRFYAEKMGEIVTD 528 +R YV++ EN++ +G V D Sbjct: 504 NREYVKITDVPGIKKDITIYSIKSENKKHIMEVYEDTDTILLGKENKKIVPTNLGITVND 563 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK 580 L + F E ++Y FTA ME LD V+ W ++ F+ +D+ K Sbjct: 564 FLMKYFPEFLDYKFTANMETDLDYVSTGTKNWVDIVQDFYDKLKPIVDELSK 615 >UniRef50_B1X1Z5 DNA topoisomerase n=3 Tax=Chroococcales RepID=B1X1Z5_CYAA5 Length = 719 Score = 332 bits (852), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 225/699 (32%), Positives = 349/699 (49%), Gaps = 77/699 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K ++++E+P K K + K+LG+D+ V ++ GHIR+ SG+ Sbjct: 16 MAKNVLVIEAPGKRKKLEKFLGADWTVIATGGHIREFDKSGN------------------ 57 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKE---KVVSELKQLAEK--ADHIYLATDLDRE 115 + +G + + +P E KV+ +L+ A++ ++ I++ATD DRE Sbjct: 58 --------HNLGFELTPKGTVIPKFVPRSERSKKVIRQLQMTAKRTNSERIFIATDPDRE 109 Query: 116 GEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 GE I WH +V+G + + R+V++EI++ A+R+A P L+ + V + R +D+++ Sbjct: 110 GECIGWHAAQVMGIKNPQ--RIVYSEISEKAVRRAIANPRFLDTNLVASALGRSTLDKLI 167 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV------------- 222 GY SPLLW + S GRVQ+ + L+ ERE I+ F PE ++ V Sbjct: 168 GYTGSPLLWDYVEGAKSMGRVQTPVLTLICEREETIQNFKPETYYSVWSLYKEGLKAFYA 227 Query: 223 ----DASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 D S + + + R ++ + V++ ++V+ E K + Sbjct: 228 GESNDNSEDSEEERDDSQTPKETQKESLRVTSEAEANRLVAIARNNSHNVVSLETKKSKK 287 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY 338 P APF TS LQQAA RL F +TM +AQ+LYEAG ITY RTDST +S D ++R Y Sbjct: 288 SPPAPFTTSNLQQAAGARLKFSPDQTMKLAQKLYEAGVITYHRTDSTVISGDFCKVIRQY 347 Query: 339 ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQLIWRQ 397 + N + LP+S ++ +N+QEAHEAIRP D+ + DA KLYQLIW + Sbjct: 348 LKAN-DPENLPKSVIKHRQSKNAQEAHEAIRPVDLAKTETDIASELGDAAGKLYQLIWFR 406 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 VA Q PA+ D TT+T + KA+G+++ F G+ + R D LP+V Sbjct: 407 TVASQCKPAELDKTTITTQSDTVFWKAKGQVVTFAGYLRYW---RDLGADSELPSVENHQ 463 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 +TL + + TKPP+RF+EA +VK EK+GIGRPST++ I T++DR YV VE R Sbjct: 464 VVTLEDAQAEKKQTKPPSRFTEAQMVKVREKKGIGRPSTFSPTIQTLKDRNYVAVEKRML 523 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ---- 573 ++G V + E+ EL +FTAQME+ LD +A + +W+ + F D Q Sbjct: 524 KPTQVGLKVYHFVREHLTELGTVEFTAQMESHLDAIAKGDEKWQPYVCQFHFDHWQPTLI 583 Query: 574 QLDKAEKDPEEGGMRPNQMVL--TSIDCPTCGRKMG-IRTASTGV----FLGCSGYALPP 626 ++ + P N L + CP C M + + S + FL C Sbjct: 584 KIAQTLGKPAVKSFNGNGKSLEKSRTKCPKCNVAMSKVPSKSKKLHRPYFLKC------- 636 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKC 665 E C+T + N+ E ++ K CPKC Sbjct: 637 -EDCETVMFY---NKERKQWESPGTKSPTQETKASCPKC 671 >UniRef50_Q02GM2 DNA topoisomerase n=10 Tax=Pseudomonas RepID=Q02GM2_PSEAB Length = 641 Score = 332 bits (850), Expect = 5e-89, Method: Compositional matrix adjust. Identities = 230/656 (35%), Positives = 343/656 (52%), Gaps = 79/656 (12%) Query: 5 LVIVESPAKAKTINKYLGS-----DYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKP 59 +VI+E+P K K + L S + V+++ GHIRDLP G + Sbjct: 3 IVIIEAPGKLKKLRSLLPSIRPDVTWQVEATAGHIRDLPVHGQDPQM------------- 49 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 + V +++ HY++L GKEK V+ LK+L +KA IY+A+D DREGE+I Sbjct: 50 -----------LTVGVGQDFKPHYQILSGKEKTVARLKELRQKAVEIYVASDPDREGESI 98 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ + G + Y RV F EITK+ I + P L++ +V +Q+ RR +DR+VGY+V Sbjct: 99 GWHILQAAGIKN--YKRVAFKEITKSCITAELSSPRRLDLPKVASQECRRVIDRLVGYLV 156 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS------GEA 233 +P L + + R +AGRVQSVAV LVV REREI+AF + + V+ + +PS E Sbjct: 157 TPELRRVMGRPTTAGRVQSVAVYLVVLREREIRAFTAIKHFGVELTFVSPSDGRTWTAEW 216 Query: 234 LALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLER-EDKPTTSKPGAPFITSTLQQA 292 + V + P+ Q + L+ R ++E D T P APFI+S+LQ A Sbjct: 217 DPVPVFASEEFPY-----VQDRQLAELVGAIRNVIVETCIDSEETDAPPAPFISSSLQMA 271 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 A L + KTM +AQRLYE G ITY RTD+ N+S+D++ +R ++ G K + E Sbjct: 272 AGNALKWSPDKTMKVAQRLYEQGLITYHRTDNPNISKDSMPDIRA-VAKALGLKCV-EQQ 329 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 + + +++QE H AI P+D MA + + AD Q LYQLI + +A Q+ A Y T Sbjct: 330 RMFKADQDAQEGHPAITPTD--WMAAAAGET-ADEQALYQLIRVRALASQIEAAVYAVRT 386 Query: 413 LT-VGAG----DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 +T +G G R A+G++L GW K++ +GD+ + + + L P Sbjct: 387 ITLLGVGPDKKPLRFGAKGKLLNVPGWRKLL----QGDDAEEQKNETPSNPIPIPALEPR 442 Query: 468 QHF-----------TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 Q T PP RF++ASLV E+++RGIGRPS+YASI+ I D+G V+++ R Sbjct: 443 QILKVYSGEVLEKKTTPPKRFTDASLVGEMKRRGIGRPSSYASIVKNIIDKGQVQMKGRS 502 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 ++GE LE NF ++ DFT +E +LD++AN E + V+ F+ +L Sbjct: 503 LIPGELGEATIALLEHNF-SFLSLDFTRNLEVALDRIANSEDTYMNVVQQFYQLLQTELQ 561 Query: 577 ------KAEKDPEEGGMRPNQMVLTS-IDCPTCGRKMGIR-TASTGV--FLGCSGY 622 A+ +P TS C CG + R A G F GCSGY Sbjct: 562 TLRALPSAQDEPRASSTASISSAPTSDFLCGKCGLPLVHRKKAGKGGFDFWGCSGY 617 >UniRef50_UPI00016C444E DNA topoisomerase I n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C444E Length = 985 Score = 332 bits (850), Expect = 5e-89, Method: Compositional matrix adjust. Identities = 210/567 (37%), Positives = 295/567 (52%), Gaps = 55/567 (9%) Query: 266 YSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GY 316 + V + E K +P PF TSTLQQ A+ R+ F +TM AQ+LYE Sbjct: 376 FVVSKAEKKTRQDRPLPPFTTSTLQQQANARMRFSASRTMQTAQKLYEGVELTGMGQVAL 435 Query: 317 ITYMRTDSTNLSQDAVNMVRGYISDN--FGKKYLPESPNQYASKENSQEAHEAIRPSDVN 374 ITYMRTDST +S DA+ VR YI G +YLP PN Y S +++QE HEA+RP+DV Sbjct: 436 ITYMRTDSTRVSNDALTAVRAYIQGTTFLGPRYLPAQPNAYKSGKSAQEGHEAVRPTDVK 495 Query: 375 VMAESLKD--MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFD 432 + + + + D +LY LIW++FVA Q TPA+ D TT + AG +A GR++ FD Sbjct: 496 ITPKDAEKAGLGGDQLRLYTLIWQRFVASQCTPAEMDVTTYEITAGRGLFRASGRVITFD 555 Query: 433 GWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIG 492 G+ KV+P + + +E LP V + D L ++L +QHFT+PP RF+E SLVK LEK GIG Sbjct: 556 GYRKVLPPVGRQEEPE-LPPVKEKDVLNRLDLFESQHFTQPPPRFNEGSLVKALEKEGIG 614 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 RPSTYASIISTIQ RGYV + RF+A ++G++VTD L ++F +M+ FT++ E LD+ Sbjct: 615 RPSTYASIISTIQKRGYVTQDRGRFFATEIGKVVTDLLVKHFPNIMDTQFTSKFETELDE 674 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAS 612 + + ++ VLD F+ F++ L A+ + P LT CP CGR M R ++ Sbjct: 675 IETGKFRYREVLDEFWDSFSKTLKSADAE------MPVARELTGEKCPKCGRDMQKRYST 728 Query: 613 T--GVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMD 670 T G F GC+GY+ P CK + GE CP CG M Sbjct: 729 TTGGFFEGCTGYSADPP--CK----------YIKPRPGEAEREGPTVTDIPCPACGKHM- 775 Query: 671 SYLIDPKRKL------HVCGNNPTCDGYEIEEGE-FRIKGYDGPIVECEKC-GSEMHLKM 722 RK+ + C P C E E R +C KC + LK Sbjct: 776 ------VRKVGRFGVFYTCEGAPDCPTTMNENAEGVRTVTALPTKHKCPKCEKHNLLLKE 829 Query: 723 GRFG-KYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFL 781 + G KY+ C + +CK +G P + V CEK + V++ G FL Sbjct: 830 SKAGKKYVQCPDAKCKFISDADADGAPVKPADTGV-----ACEKCGSPMVIKVAWRGPFL 884 Query: 782 AANTFPKSRETRAPLVEELYRFRDRLP 808 + + +PK R ++ E + +D LP Sbjct: 885 SCSGYPKCRNAKSINAELREKLKDILP 911 Score = 188 bits (477), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 111/244 (45%), Positives = 150/244 (61%), Gaps = 35/244 (14%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LV+VESPAKAKTINKYLG ++ V +S GH+RDL T K KK Sbjct: 49 GFDLVVVESPAKAKTINKYLGPNFRVLASYGHVRDLDT------------------KKKK 90 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKE------------KVVSELKQLAEKADHIYLA 109 E A G+D + W+ Y V G + +++ E+ + A +A+ +YLA Sbjct: 91 GEDIA-----GIDIANGWKLRYTVDDGSKSEGGRKRFRTAKEILGEIGREASRANKVYLA 145 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARR 169 +D DREGE+IAWH+ + + DA R+ FNEITKNA+ A ++N RV+AQ+ARR Sbjct: 146 SDPDREGESIAWHIADELKLPDATTYRIRFNEITKNAVNAALAGAEKINDLRVSAQEARR 205 Query: 170 FMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 MDRVVG+ +S LL KK+A LSAGRVQSVAV+L+V+REREI+AF EE+W++ A P Sbjct: 206 AMDRVVGFPLSNLLGKKVASRLSAGRVQSVAVKLIVDREREIEAFKTEEYWKITALLAAP 265 Query: 230 SGEA 233 +A Sbjct: 266 GVKA 269 >UniRef50_P78032 DNA topoisomerase 1 n=2 Tax=Mycoplasma RepID=TOP1_MYCPN Length = 711 Score = 331 bits (848), Expect = 9e-89, Method: Compositional matrix adjust. Identities = 228/751 (30%), Positives = 369/751 (49%), Gaps = 111/751 (14%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LV++ESP K KT+ KYL +D+ + S++GHIR++ Sbjct: 1 MSKNLVVIESPNKVKTLQKYLPNDFEIVSTIGHIREMV---------------------- 38 Query: 61 KDERGALVNRMGVDP-WHNWEAHYEV--------------LPGKEKVVSELKQLAEKADH 105 + N P W +W + L K ++ +K+ A KA + Sbjct: 39 --HKNFGFNEADYSPVWEDWTKSKKKFSSLSFKGNLKGKKLLSKYDIIKSIKEKASKATN 96 Query: 106 IYLATDLDREGEAIAWHLREVIG-GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNA 164 IYLATD DREGEAI+WH+ +V+ D ++ R+ FNEITKNA+ A P E++ V + Sbjct: 97 IYLATDPDREGEAISWHVYDVLDEKDKSKCQRITFNEITKNAVLDALKNPREIDQSWVQS 156 Query: 165 QQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 Q AR+ +DR++G+ +S LL ++ SAGRVQSVA+R + ERE+EI++FVP +W +D Sbjct: 157 QFARQILDRMIGFRLSRLLNNYLS-AKSAGRVQSVALRFLEEREQEIRSFVPRFWWTLDV 215 Query: 225 STTTPSGEALALQVTHQNDK-PFRPVN----------KEQTQAAVSLLEKAR-------- 265 P E + +++ R +N +E++ + + L++A Sbjct: 216 -LLNPKAEGVREACANRSIPIVLREINPALRAGLKFEEEKSVSGIDFLDEASAKKFGEQL 274 Query: 266 ------YSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA----- 314 Y++ E K +S P + + T++LQ+ A +LG+ KK ++AQ LYE Sbjct: 275 KGVFEVYNI--DETKHYSSSPNSAYTTASLQKDAINKLGWSSKKVTLIAQHLYEGVSING 332 Query: 315 ---GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENS---QEAHEAI 368 I+Y RTDST LS + YI +++G+KYL K+ Q+AHEAI Sbjct: 333 EQTALISYPRTDSTRLSAQFQQSCKEYILNHYGEKYLSNRIVSAKGKKGEKIIQDAHEAI 392 Query: 369 RPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGR 427 P+D+N+ E +K+ ++ D LY+LIW + VA M K T + + A + Sbjct: 393 HPTDINITPEMVKNAIKKDEFLLYRLIWIRTVASLMADCKKSHTHIRFINDGNKFYASSK 452 Query: 428 ILRFDGWTKVMPALRKGDEDRI---LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVK 484 L FDG+ K+ + + + L + GD ++ T P AR+++ASL++ Sbjct: 453 SLVFDGYRKIYEHFENKESNDLYIDLDKIRVGDRFMAKDIKITARQTHPAARYTQASLIE 512 Query: 485 ELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTA 544 LEK IGRPSTY ++ S DRGY + F+ ++GE V + L ++F +++N +FT Sbjct: 513 ALEKSNIGRPSTYNTMASVNLDRGYASLNKHAFHVTQLGEQVNEELSKHFGKIINKEFTK 572 Query: 545 QMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR--PNQMVLTSIDCPTC 602 ME SLD++A ++ ++ L F+S+F +++ A EG ++ + DCP+C Sbjct: 573 NMEKSLDEIAENKKNYQEFLRDFWSNFKEEVKLA-----EGSIQRVKKEKEFVGRDCPSC 627 Query: 603 GRKMGIRTASTG--VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKR 660 + R G F+GCS + CK N +N+ LE + + Sbjct: 628 ASPLLYRYTKRGNEKFVGCSNFP-----NCK--YNEFSQNKPNLTLE---------KLEE 671 Query: 661 RCPKCGTAM--DSYLIDPKRKLHVCGNNPTC 689 CP+C + + +P + C N P C Sbjct: 672 LCPECNSQLVKRRTKFNPNKTFVGCSNFPRC 702 >UniRef50_A6G953 DNA topoisomerase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G953_9DELT Length = 891 Score = 324 bits (831), Expect = 7e-87, Method: Compositional matrix adjust. Identities = 193/496 (38%), Positives = 281/496 (56%), Gaps = 49/496 (9%) Query: 265 RYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------G 315 RY+V + E + T+SKP APFITSTLQ AAS+ LGF ++TM +AQ LYE Sbjct: 327 RYTVRKIETRQTSSKPSAPFITSTLQMAASSSLGFSAQRTMRLAQDLYEGVELAGEGQVA 386 Query: 316 YITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYAS-KENSQEAHEAIRPSDVN 374 ITYMRTDST+LS +A+N VR +I +GK YLPE +++S +++QEAHEAIRP+DV Sbjct: 387 LITYMRTDSTHLSPEAINSVREFIDGRYGKAYLPEKARKFSSTNKDAQEAHEAIRPTDVK 446 Query: 375 VMAE----SLKDMEADAQ-KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFR----LKAR 425 + E +K A+ Q KLY+LIW +FV CQM PA++ ST++ + D L+A Sbjct: 447 LDPELIRAKIKGPRAEEQYKLYKLIWSRFVGCQMNPARWASTSVHLHRSDVETGAVLRAS 506 Query: 426 GRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKE 485 GR+L FDG+ + DE + LP + +GD ++TP Q F+ PP R+SEASLVK Sbjct: 507 GRVLAFDGFYRATGVPTASDE-QTLPKLAEGDTYAPFQVTPKQKFSSPPPRYSEASLVKA 565 Query: 486 LEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQ 545 LE GIGRPSTYASII +Q R YV +RRFYA +GE+VTD+L E F +LM+ +T Q Sbjct: 566 LESEGIGRPSTYASIIQLVQSRNYVEQRDRRFYASDLGEVVTDKLIEAFPDLMDVGYTRQ 625 Query: 546 MENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSI-DCPTCGR 604 ME LD++ +W A+L F++ F+ L+ A EG + ++ CP CG Sbjct: 626 MERELDEIEGQNVDWVAMLRRFYTAFSSALEVA----HEGMAHAKAEIQPALYKCPKCGA 681 Query: 605 KMGIRTASTGVFLGCSG-----YALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAK 659 + R G FL C+ YA P + + L+PE ++++ ED + LR Sbjct: 682 RTCYRFGRNGRFLSCTAYPECDYAAPIDRKGRP---LLPER--VDIVSPEDGSSMELRNG 736 Query: 660 RRCPKCGT---AMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGS 716 R + S++++ RK ++ ++EEG ++C KC + Sbjct: 737 RFGKFLASENYEKGSFVLNLDRKGNIKYPAIPPLVIDVEEG-----------IQCVKCDA 785 Query: 717 EMHLKMGRFGKYMACT 732 ++L+ G G ++ C+ Sbjct: 786 PLNLRRGARGPWLGCS 801 Score = 251 bits (641), Expect = 9e-65, Method: Compositional matrix adjust. Identities = 131/222 (59%), Positives = 162/222 (72%), Gaps = 21/222 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK LVIVESPAKAKTINKYLG D+VV++SVGHIRDLP S + + K+P Sbjct: 12 GKQLVIVESPAKAKTINKYLGEDFVVRASVGHIRDLP-----------SRAPRGTKQPVP 60 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 GVD +++ YE+L K K V+ELK+ A+ A I+ ATDLDREGEAIAW Sbjct: 61 ----------GVDLENDFRPTYEILSEKTKTVAELKRDAKAASDIWFATDLDREGEAIAW 110 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL E++ + + RVVFN ITK I++AF+KP +++DRVNAQQARR +DR+VGY SP Sbjct: 111 HLAEILDVEASVAKRVVFNAITKEEIKRAFSKPRAIDVDRVNAQQARRILDRIVGYQASP 170 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD 223 LLWKK+ARGLSAGRVQSVAVRLVVEREREI+A VP+E W++D Sbjct: 171 LLWKKVARGLSAGRVQSVAVRLVVEREREIEAHVPDETWKID 212 Score = 55.1 bits (131), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 45/135 (33%), Positives = 60/135 (44%), Gaps = 7/135 (5%) Query: 661 RCPKCGTAMDSYLIDPKRKLHVCGNNPTCD-GYEIEEGEFRIKGYDGPIVECEKCGSEMH 719 +CPKCG A Y + C P CD I+ + IV E GS M Sbjct: 675 KCPKCG-ARTCYRFGRNGRFLSCTAYPECDYAAPIDRKGRPLLPERVDIVSPED-GSSME 732 Query: 720 LKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPL---PELPCEKSDAYFVLRDG 775 L+ GRFGK++A N E+ + R G + P P+ + + C K DA LR G Sbjct: 733 LRNGRFGKFLASENYEKGSFVLNLDRKGNIKYPAIPPLVIDVEEGIQCVKCDAPLNLRRG 792 Query: 776 AAGVFLAANTFPKSR 790 A G +L + FPK R Sbjct: 793 ARGPWLGCSRFPKCR 807 >UniRef50_Q9JN65 DNA topoisomerase 1 n=2 Tax=Mycoplasma gallisepticum RepID=TOP1_MYCGA Length = 719 Score = 324 bits (831), Expect = 9e-87, Method: Compositional matrix adjust. Identities = 218/656 (33%), Positives = 341/656 (51%), Gaps = 58/656 (8%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLP--TSGSAAKKSADSTSTKTAKKPKKD 62 ++++ESP K KTI KYL DY + ++VGHIRDLP T G + KKP K Sbjct: 8 ILVIESPNKVKTIKKYLTDDYEIVATVGHIRDLPKYTLGFNTEDFVPKWEIIQEKKPAK- 66 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 GV + + + K++++ EL A+KAD IYLATD DREGEAI+WH Sbjct: 67 ---------GVSATKKAKTVKKAVKNKKEIIDELVDKAKKADEIYLATDPDREGEAISWH 117 Query: 123 LREVI---GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 + +V+ G + + R++FNEI++ A++ A P E+ D V++Q RR +DR++G+ + Sbjct: 118 VYDVLKEKGVNVNKCKRIIFNEISEKAVKNAIANPREIQKDWVSSQITRRRLDRLIGFKL 177 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 S L+ KI SAGRVQS+A++ + ERE I FVP +W +D G L L+ Sbjct: 178 SSLMKSKI-NADSAGRVQSIALKFITEREELINKFVPRFWWTLDV--ILKDGTELMLRKI 234 Query: 240 HQNDKP---FRPV--------NKEQTQAAVSLLEKARYSVLERED-KPTTSKPGAPFITS 287 + K F+ + N ++ V +Y V + K +S P + TS Sbjct: 235 DEKLKDKLGFKELEEVSGIDFNTKEDAELVKQHLSDKYRVYAIDTPKLKSSYPKEVYKTS 294 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYI 339 TLQQ A +L + K +AQ LYE I+Y RTDST LS + V ++ Sbjct: 295 TLQQDAINKLKWRSMKITSVAQELYEGVTIDDEQIALISYPRTDSTRLSPEYGKTVLDFV 354 Query: 340 SDNFGKKYLP-------ESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLY 391 + +GK Y+ E+ K Q+AHEAI P D+++ +S+K+ + +D LY Sbjct: 355 AKTYGKDYVATQSQLNGETKANKKQKAKVQDAHEAIHPIDISITPDSVKNKISSDQYSLY 414 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILP 451 +LIW + VA M A Y+ + + + A L+FDG+ K+ D R L Sbjct: 415 KLIWTRTVAHYMAAAVYELVNIRFINNNNKFYAVNNTLKFDGYKKIYTHYDDKDHLRKLD 474 Query: 452 ----AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 A++K V L +H TKPPARF++A+L++ LE GIGRPSTY++I+ + R Sbjct: 475 LNHFAIDKEFEAKDVLLN--EHQTKPPARFTQATLIEALETEGIGRPSTYSTILDIVLKR 532 Query: 508 GYVRVENRRFY-AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 Y + N R+Y +G+ + L++NF ++N +FT ME +LD++A + L Sbjct: 533 NYAELVNGRYYKTTDLGQKLAFELDKNFPTIINKEFTKNMETTLDEIAQGTVNDVSYLQA 592 Query: 567 FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGY 622 F++DF++ L++A+ + + + +CP C ++ R G F+GCS + Sbjct: 593 FWNDFSEVLNEAKTN-----IVKKVEYIEGKNCPNCSSQLVRREGRYGPFVGCSNF 643 >UniRef50_B1AJN1 DNA topoisomerase I n=15 Tax=Ureaplasma RepID=B1AJN1_UREP2 Length = 681 Score = 322 bits (826), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 224/723 (30%), Positives = 369/723 (51%), Gaps = 96/723 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L++VESP K K+I YLG Y V ++ GH+R+L AKKS Sbjct: 5 MQKDLIVVESPNKIKSIQSYLGDSYNVIATCGHLREL------AKKS------------- 45 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQ------LAEKADHIYLATDLDR 114 G DP ++ +E++ K +S+ +Q LA+K+++IYLATD DR Sbjct: 46 -----------GYDP-KTYDLKWEIIKTTNKKLSKKQQIKTIIDLAKKSNNIYLATDPDR 93 Query: 115 EGEAIAWHLREVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 EGEAI+WH+ +++ D R R+ FNEIT+ AI ++ ++ +++ + V++Q ARR +DR Sbjct: 94 EGEAISWHVYDLLPKKDKERVKRITFNEITQKAILKSIDEKHDIDFNLVDSQFARRILDR 153 Query: 174 VVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA 233 V+GY +S L+ KK GLSAGRVQS+A+ VVERE E ++FV EE+++++ + Sbjct: 154 VIGYKLSGLV-KKNLHGLSAGRVQSIALLFVVERELERRSFVKEEWYQIEGIIEKNIFVS 212 Query: 234 LA-----LQVTHQ---NDKPFRPVNKEQTQAAVSLLEKARYSVLERED-KPTTSKPGAPF 284 L +++ +Q +D + ++K+ Q + L + V +D K T P Sbjct: 213 LRKIPYDVELYNQKDNSDSDLKFLHKKDAQRVIDDLSDI-FKVYSIDDLKITKGDVQLPL 271 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVR 336 T L Q AS G+ KT ++AQ+++E ITY RTDS LS D + Sbjct: 272 TTDKLLQIASNNFGWSANKTTLIAQQMFEGLEINNQQLALITYPRTDSERLSDDFLQEAN 331 Query: 337 GYISDNFGKKYLPESPNQYASKE--NSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQL 393 +I +NFGK+YL N+ +++ N Q+AHEAIRP D+N+ E +KD + D KLY L Sbjct: 332 AFIENNFGKEYLENFKNKKINRKEVNIQDAHEAIRPVDINLKPEEIKDYVSLDIYKLYNL 391 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILP-A 452 +W + ++ M ++ + +++ + +R G+ + ++ DE P Sbjct: 392 VWNKTLSALMKVPTFNKQVIRFINNEYKFYTAYKTIRTLGYWILDFYKKQRDELEFQPPI 451 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 +N GD ++ Q T PP ++EASL+ L+ G+GRPSTYA++ + RGY+ Sbjct: 452 INVGDEFKKEKIDLIQKETTPPPYYTEASLIAALKNAGVGRPSTYATMATIGTTRGYINK 511 Query: 513 ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 + + ++G V L+E F ++++ FT++ME LD +AN + WK ++ F F Sbjct: 512 DKSKLIPTELGIKVIQELKEAFPKVISIKFTSEMEERLDVIANGKLFWKDLVSTFIPIFE 571 Query: 573 QQLDKA----EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV-FLGCSGYALPPK 627 +++ +A EK P+E + N++ CP C + I+ + F+ CS + Sbjct: 572 EEVKQAYTKIEKVPDE---KINRL------CPICAHDLLIKRSRMNTRFIACSNFP---- 618 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNP 687 C+ T +L + E+LN L CP C ++ + C P Sbjct: 619 -TCRFTESL-EKPEILNEL---------------CPNCSKSLVKRKNRKNKYFIGCTGYP 661 Query: 688 TCD 690 C+ Sbjct: 662 ECN 664 >UniRef50_Q04TE1 DNA topoisomerase n=4 Tax=Leptospira RepID=Q04TE1_LEPBJ Length = 613 Score = 319 bits (817), Expect = 4e-85, Method: Compositional matrix adjust. Identities = 209/640 (32%), Positives = 344/640 (53%), Gaps = 63/640 (9%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 +L+IVESP+KAKTI YLG ++ + +++GH+ DLP + Sbjct: 3 SLIIVESPSKAKTIGGYLGKEFRILATLGHVADLPKTT---------------------- 40 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +G+D + +E Y VLPGK+K++SE+ + A+++ I+LATD DREGE I+ ++ Sbjct: 41 -------LGLDLKNRFEPEYVVLPGKKKILSEIIKAAKESQRIFLATDPDREGEFISAYI 93 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 R+ + + R+ F EIT+NAI + P ++ V AQ+ RR DR++GY +SP+L Sbjct: 94 RDRLKKKSNVF-RIRFTEITRNAILSSLQNPDTIHESLVEAQKTRRVGDRLIGYFISPVL 152 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 W++I GLSAGRVQSVA++ + +RE EI+ F E ++ V G Q D Sbjct: 153 WREIGPGLSAGRVQSVALKWICDREDEIRNFHSEIYYNVLLYVHDKKGIEGVFQ--RVGD 210 Query: 244 KPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 + F ++E+ + ++K + + E+++ + P PF T++LQQ A +L F K Sbjct: 211 RIF---SEEKANLILQNVQKEKNLRISEKKESHKKNLPPPPFQTASLQQEAFRKLRFSSK 267 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 KTM +AQ+LYE G ITYMRTDS LS D V +I FG+ + + Sbjct: 268 KTMSIAQKLYEGMDLGNGKREGLITYMRTDSVRLSPDFVERANSWIISEFGETFANKLER 327 Query: 354 QYA-SKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 + S + Q+AHEAIR +D + +ES K+ + + LY+LIW++ ++ + P ++ +T Sbjct: 328 KVKKSSKKIQDAHEAIRITDPFLTSESAKNFLGKEEASLYELIWKRTISYLLPPEEFLNT 387 Query: 412 --TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 ++ V F+L+ + + F G+ + A +K + P KG+ LTL + + Sbjct: 388 EYSIFVAGEYFQLETKKTL--FPGYKILNEADKKAN-----PNWEKGELLTLQKAECEKK 440 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 T+P R+SE +LV +LE+ GIGRPSTY+++ + R YV E + FY +GE V Sbjct: 441 QTEPSPRYSEGTLVAKLEREGIGRPSTYSTVSEILVKRKYVEQEKKFFYPLPLGEKVNFF 500 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE-----KDPEE 584 L+ F +L FTA++E++LD++ +E + +L+ +SD Q+ ++ E Sbjct: 501 LQSGFGDLFREKFTAELESNLDRIEKNEIDSLVILNRLWSDLQTQIQNSKFVASVFRKEW 560 Query: 585 GGMRPNQMVLTSIDCPTC--GRKMGIRTASTGVFLGCSGY 622 +R + + CP C G +T+ F CS + Sbjct: 561 AEIREKKKETSWGICPLCRDGSLQKKKTSRKKEFYQCSRF 600 >UniRef50_B7J7I8 DNA topoisomerase I, putative n=1 Tax=Acidithiobacillus ferrooxidans ATCC 23270 RepID=B7J7I8_ACIF2 Length = 705 Score = 315 bits (808), Expect = 4e-84, Method: Compositional matrix adjust. Identities = 230/692 (33%), Positives = 335/692 (48%), Gaps = 93/692 (13%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+IVESP KA I LGS + VK++VGHIRDLP G AA Sbjct: 4 LLIVESPTKAHHIQAMLGSGWSVKATVGHIRDLPIKGDAAY------------------- 44 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 V P +++ +YE+ K V L+ A A+ +Y+ATD DREGEAIAWH+ Sbjct: 45 --------VRP-PDFKLNYEITERASKTVPALRAAARDAESVYIATDPDREGEAIAWHVC 95 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 +V+G RV + E+T+ AIR+A P +N+ V AQ+ARR +DR+VG+ VS L Sbjct: 96 QVLGIKPGAAKRVTYQEVTEPAIRKAIAAPRTVNMPLVAAQEARRALDRIVGWEVSGPLS 155 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST----TTPSGEALALQVTH 240 I SAGRVQ+ A+ LVV RE+ I+ F P +++V A P A+ + T Sbjct: 156 NAIGSRASAGRVQTPALSLVVAREQAIRQFKPTPWFQVLAHVAGKDAAPDWRAVWVDGTQ 215 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + F+ +K +A L V + E KP P PF TS++Q + L Sbjct: 216 EGEY-FQ--DKAHAKALADALPSMALKVTKAETKPVRKPPAPPFTTSSMQMDGARALKAP 272 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP--ESPNQYASK 358 V M AQ L+E G+ITY RTDS NLS++ ++R + K+ LP E+P ++ SK Sbjct: 273 VDAIMKAAQSLFEHGHITYHRTDSPNLSEEGEGLLRAALK----KENLPLVETPRRWRSK 328 Query: 359 ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG 418 +QEAHEAIRP+ V D+E Q LY LI ++ +A QM A Y T+ T+ G Sbjct: 329 GGAQEAHEAIRPTRPMVRQAGENDLE---QALYDLIRKRALASQMPDAVYQQTSCTLDGG 385 Query: 419 DFR-----LKARGRILRFDGWTKVMPALRKGDEDRILPAVNK------GDALTLVELTPA 467 F+ +A G +L+ GW + + +E PA N GDA+ Sbjct: 386 MFQGRPAVFRAVGSVLKDPGWMALYRETAEDEEGTENPAANPVPRLAVGDAVRAARGECL 445 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR--FYAEKMGEI 525 TK P R++E++L+K LE G+GRPSTYASI+ + R Y+R + + YA ++GE Sbjct: 446 SKTTKAPPRYTESTLIKALEDHGVGRPSTYASILKNLFAREYIRRKGKSPALYATELGEK 505 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 + + L + + N D+T ++E LD++ + + +L F+D + LD Sbjct: 506 IVEAL--SVFDFSNVDYTREVEADLDRITEGQMRPRDLLAKSFADIQRILDAM------- 556 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYA--LPPKERCKTTINLVPENEVL 643 P Q CP GC G L K + + + Sbjct: 557 ---PTQARAQGRPCP---------------IEGCDGTVRRLESKRKPGVFFWMCSNRDAH 598 Query: 644 NVLEGEDAETNALRAKR-------RCPKCGTA 668 +L+ D E A A+R CP+CG A Sbjct: 599 PLLQDNDGEPGAPFAERVEAGDGPACPECGAA 630 >UniRef50_B3PMD8 DNA topoisomerase I n=3 Tax=Mycoplasma RepID=B3PMD8_MYCA5 Length = 620 Score = 315 bits (807), Expect = 5e-84, Method: Compositional matrix adjust. Identities = 210/636 (33%), Positives = 338/636 (53%), Gaps = 61/636 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + ++IVESP K KTI +Y+GSDY V SSVGHI L TSG Sbjct: 1 MDQKVLIVESPNKVKTIQQYVGSDYNVVSSVGHILKLSTSG------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 V+ +G+D + NWE K KV+ LK + A + +ATD DREGEAIA Sbjct: 42 -------VDGLGID-FTNWEPMMIQDRTKAKVIKALKDATKNAKEVLIATDPDREGEAIA 93 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +L + + Y R+ +NEIT AI++A P ++ + V AQ+ RR +DR++G+ +S Sbjct: 94 QNLVDTLKLSKI-YRRIKYNEITAEAIKEALENPQMIDDNLVKAQKTRRMLDRIIGFRLS 152 Query: 181 PLLWKKIARGLS---AGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 L+ +K+ S AGRVQS+A++LV ++E+EIKAF+P ++ ++ A + E + Sbjct: 153 QLMKRKVKNAPSLPSAGRVQSIALKLVCDKEKEIKAFIPIKYNKIQAKIS----EDVIAD 208 Query: 238 VTHQNDKPFRPVNK----EQTQAAVSLLEKARYSVLEREDKPTTSKPG--APFITSTLQQ 291 + + F+ N E+ + V+ L K + S+L ++ K + K PF S L + Sbjct: 209 FYYPTNSDFKNDNTWILPEKIDSIVAELNKNK-SLLVKDFKVSQRKESQITPFKQSVLYK 267 Query: 292 AASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 A + + AQ+L+E G I+Y RTDST +S + R YI + FG+ Y+ Sbjct: 268 EAK----YSATTVQISAQKLFEMGLISYPRTDSTRMSDTFIAKAREYIKEKFGENYVASD 323 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLK---DMEADAQKLYQLIWRQFVACQMTPAKY 408 ++ +Q+AHEAIRP+D+ ++ + K D+ +Y +I+ + ++ MTP Sbjct: 324 IKSFSG---AQDAHEAIRPTDIYLIPQVAKTKYDLGEVESYIYTIIYNKTMSSLMTPPVR 380 Query: 409 DSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQ 468 + + G + K + FDG+ +V+ +E + LP G+A+ ++E T Sbjct: 381 EIYRYELVNGLYYFKMSYSKVIFDGYYRVL----NFEEPKPLPKYEIGEAIPVLEFTRFD 436 Query: 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528 T+PPAR++E SL+K L+ +GRPST+AS I+ I+ R +V N + GE+V Sbjct: 437 KETQPPARYNEGSLIKMLDDIKVGRPSTFASTINIIKKRLFVETINGALHPTVFGEVVLK 496 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 +L E F + ++TAQ+E LD+V+ +A++K +L+ F++ F + D A K E M Sbjct: 497 KLIEGFPNTITEEYTAQVEEELDEVSEGKADYKILLEDFWNRFQRSYDDASKTIEISIM- 555 Query: 589 PNQMVLTSIDCPTCGRKMGIRTAST--GVFLGCSGY 622 P + + S CP CG + R S F+GCS + Sbjct: 556 PQEFLERS--CPRCGSTLLYRNNSKKHTKFIGCSNF 589 >UniRef50_A1U7T2 DNA topoisomerase I n=2 Tax=Marinobacter RepID=A1U7T2_MARAV Length = 729 Score = 315 bits (807), Expect = 5e-84, Method: Compositional matrix adjust. Identities = 217/600 (36%), Positives = 313/600 (52%), Gaps = 70/600 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 MG+ LVIVESPAK+K I LGS+Y V +SVGH+RDLP P+ Sbjct: 1 MGQILVIVESPAKSKKIQTILGSNYRVAASVGHMRDLP--------------------PR 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD + Y V GK +VVS LK+LA +D + LATD DREGEAIA Sbjct: 41 D---------LGVD-LETLKPTYVVSEGKSQVVSNLKRLAGMSDEVILATDPDREGEAIA 90 Query: 121 WHLREVIG-GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WHL+ + DD + RV + EIT++AI +A PG +++ V AQ++RR +DR++GY V Sbjct: 91 WHLKVALRLPDDVK--RVSYQEITRDAIMKAMANPGRIDMKLVAAQESRRVLDRLIGYQV 148 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP L K LSAGRVQSVAV+ VV+REREI+AF P + + +L +T Sbjct: 149 SPALSSKANLSLSAGRVQSVAVKFVVDREREIQAFQPRGYNVCTLRLAGHPNVSASLDMT 208 Query: 240 HQNDKPFRPVNKEQTQA--AVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 PF P ++ +A A R +++ E KP KP + F T LQ A Sbjct: 209 -----PFVPKDERLWKASDAQPFAGPQRVKLVKVEKKPNAVKPKSAFTTVDLQGVAGKIF 263 Query: 298 GFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYAS 357 G K+ M AQ L+E G ITY RTDS NLS + + ++ Y+S + + ++ S Sbjct: 264 GLSAKEVMAAAQTLFEQGLITYHRTDSPNLSDEGIAKIQSYLSGQ--GVPIADQVVRHKS 321 Query: 358 KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA 417 K ++QEAHEAIRP+DV+ D E + +Y LI R+ + P D+ T V Sbjct: 322 KGDAQEAHEAIRPTDVSAATAGQTDTE---KNVYSLI-RERAMLSVMPNGIDAVTQYVFQ 377 Query: 418 GDFRLK------------ARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELT 465 + R+ A+G +++ GW R +D LP + +G + + Sbjct: 378 SERRVPGLSGRPVNPMYMAKGSVVQEKGWRAYAKLERIKSKDTPLPLLEQGR-IYDGSVA 436 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-----ENRRFYAE 520 Q T+PP+R++E +L+K LE +GIGRPSTYA I+ I++R Y+ ++ F Sbjct: 437 AVQKTTEPPSRYNEQTLIKALEAKGIGRPSTYAQIMENIKNRSYIEPKPGSGKSPAFVPG 496 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW----KAVLDHFFSDFTQQLD 576 K+G + D L M+Y +T +E SLD+VA + + V D SD ++L+ Sbjct: 497 KLGYYIVDALSRF--SFMSYTYTRAVEASLDKVARGSMSYVGLVRPVSDQLTSDIAERLE 554 >UniRef50_Q4A5N2 DNA topoisomerase n=2 Tax=Mycoplasma RepID=Q4A5N2_MYCS5 Length = 625 Score = 315 bits (806), Expect = 6e-84, Method: Compositional matrix adjust. Identities = 208/633 (32%), Positives = 320/633 (50%), Gaps = 55/633 (8%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP K KTI KYLG+DY V S VGHI + TSG Sbjct: 4 LVIVESPNKVKTIQKYLGNDYNVISCVGHIYKMKTSGPFG-------------------- 43 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +G+D + NWE YE K+KV ELK +KA +Y+ATD DREGE+I +L Sbjct: 44 ------LGID-FENWEPLYEFDSTKKKVGKELKDSLKKAQMVYIATDPDREGESIGENLV 96 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 + +D Y RV +NEITK+AI +AF+ P +LN +NAQ++RR +DR++G+ +S LL Sbjct: 97 SYLKLND-NYKRVTYNEITKDAILKAFDNPHDLNWALINAQKSRRMLDRIIGFRLSKLLQ 155 Query: 185 KKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 K+ SAGRVQS+A++LV++REREI AFVP ++W+++A + +L Q ++ Sbjct: 156 SKLQNAPSNASAGRVQSIALKLVIDREREILAFVPTKYWKLNAFLLNEN--SLKAQYFNE 213 Query: 242 NDKPFRP--VNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 + + + + Q + EK + ++ T K + Q A R + Sbjct: 214 ENSSGQKEWIFESQIKEVKEFFEKLKDKKVKVTKINVTEKKNKALVPFK-QAAIYKRSPY 272 Query: 300 GVKKTMMMAQRLYE----AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQY 355 T Q+LYE G I+Y RTDST LSQ VN + +I +G ++ + Sbjct: 273 SAAMTQSTLQKLYEGYGDGGLISYPRTDSTRLSQTFVNQAKKFIESKYGSDFVSSEVKGF 332 Query: 356 ASKENSQEAHEAIRPSDVNVMAESLKDM----EADAQKLYQLIWRQFVACQMTPAKYDST 411 Q+AHEAIRP+D+N++ E+L+ + ++ LY+LI+ + + P S Sbjct: 333 TG---DQDAHEAIRPTDLNLLPENLEKLYPTISSNEVNLYKLIYEHTLKALIKPPVIKSK 389 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + K + F G+ V K ++D P +T+ T Sbjct: 390 QYIYQVDKYLFKNSFATVTFQGYYCVSAPEEKQEKD---PNFEINQEVTVNNFAFEDLET 446 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRL 530 KP R+++ SL++ L+ +GRPST+AS + I+DR YV V ++ G IV D+L Sbjct: 447 KPTPRYNDGSLIEALDDIKVGRPSTFASTVKIIKDRQYVEVLDSNAIKPTDFGMIVLDKL 506 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 NF E++N +TA++E LD ++ ++ E V+ F++ F + D+ E+ + N Sbjct: 507 VNNFPEIINEKYTAEVEGQLDLISENKLEKNQVMHDFYTKFNELYDQVASTMEKTRLEDN 566 Query: 591 QMVLTSIDCPTCGRKMGIR-TASTGVFLGCSGY 622 DCP C K+ IR F+GC + Sbjct: 567 ---FLDEDCPDCSGKLLIRLNRKKQKFIGCKSF 596 >UniRef50_O49571 DNA topoisomerase like-protein n=1 Tax=Arabidopsis thaliana RepID=O49571_ARATH Length = 1179 Score = 315 bits (806), Expect = 6e-84, Method: Compositional matrix adjust. Identities = 189/524 (36%), Positives = 286/524 (54%), Gaps = 51/524 (9%) Query: 83 YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARY-----SRV 137 YEVLP ++ LA +A+++ LA+D DREGEAIAWH+ E++ A + +RV Sbjct: 496 YEVLPS----YGHIRDLATRAENLILASDPDREGEAIAWHIIEMLQQQGALHESMTVARV 551 Query: 138 VFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQ 197 VF+EIT++AI+ A P E++ D V+A ARR +D ++G+ +SPLLW+K+ SAGRVQ Sbjct: 552 VFHEITESAIKSALQSPREIDGDLVHAYLARRALDYLIGFNISPLLWRKLPGCPSAGRVQ 611 Query: 198 SVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA-LALQVTHQNDKPFRPVNKEQTQA 256 S A+ LV +RE EI F P+E+W V A + +T N K ++ Sbjct: 612 SAALALVCDRESEIDGFKPQEYWTVGIKVKGKDNSATFSAHLTSLNSKRLNQLSISSEAN 671 Query: 257 AVSLLEKARY-SVLEREDKPTTSK--PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE 313 A + ++ + L + K +T++ P P+ITSTLQQ A+ +L F TM +A Sbjct: 672 AQDIEQRIKSEGFLVKGTKTSTTRKNPPTPYITSTLQQDAANKLHFSTAHTMKIAD---- 727 Query: 314 AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSD 372 +A+ ++ +++ +GK + +SP +Y K +N+QEAHEAIRP+D Sbjct: 728 ----------------EAIKDIQSLVAERYGKNFTSDSPRKYFKKVKNAQEAHEAIRPTD 771 Query: 373 VNVMAESLKDM-EADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRI--L 429 + + ++ + +AD+ KLY LIW + VACQM PA L +G + R + Sbjct: 772 IRRLPSTIASLLDADSLKLYTLIWSRAVACQMEPASIAQIQLDIGNASESIIFRSSCSKV 831 Query: 430 RFDGWTKV-----MPALRKGDED---------RILPAVNKGDALTLVELTPAQHFTKPPA 475 F G+ V A++ D D + L ++ GD L + E+ QH T+ P Sbjct: 832 EFLGYQAVYEDPEAKAIKNNDNDQSSEREETFKTLSSLKDGDLLQIGEVELKQHHTQHPP 891 Query: 476 RFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFR 535 R+SE SLVK+LE+ GIGRPSTYASI +Q R YV ++NR Y E +V+ L F Sbjct: 892 RYSEGSLVKKLEELGIGRPSTYASIFRVLQHRKYVTIKNRVLYPEFRARMVSAFLTHYFT 951 Query: 536 ELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 E+ +Y FTA ME LD V+ EWK +L +++ F+ + E Sbjct: 952 EITDYSFTADMETELDNVSGGVTEWKGLLRDYWTRFSAYCKRVE 995 >UniRef50_C4XEP1 DNA topoisomerase n=2 Tax=Mycoplasma RepID=C4XEP1_MYCFE Length = 629 Score = 311 bits (797), Expect = 7e-83, Method: Compositional matrix adjust. Identities = 210/637 (32%), Positives = 339/637 (53%), Gaps = 60/637 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP K +TI KYLGSDY V +SVGHI + T +K E+ Sbjct: 7 LVIVESPNKVETIKKYLGSDYDVIASVGHIAIMST--------------------RKGEQ 46 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 G +G+D NWE Y + K+ V+ LK+ KAD IY+ATD DREGEAI H+ Sbjct: 47 G-----LGID-LENWEPFYSLDNSKKNVIKNLKEAIAKADVIYIATDPDREGEAIGDHIV 100 Query: 125 EVIGGDD-----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 + D +Y R+ +NEITK AI++A P EL+ + +N+Q+ARR +DR++G+ + Sbjct: 101 NFLIEKDRNKNKKKYYRIKYNEITKEAIQKAIQNPTELDQNLINSQKARRMLDRIIGFKL 160 Query: 180 SPLLWKKIA---RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 S L+ KKI+ R SAGRVQS+A++LVV+RE EI AFVP + +V+A ++ + Sbjct: 161 SQLMQKKISNSPRTPSAGRVQSIALKLVVDREDEINAFVPRGYHKVEAKLNETLSASIYI 220 Query: 237 QVTHQNDKPF-RPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 +K + P E+ + +S+ +VLE ED K A + + L+QA Sbjct: 221 DKHPAAEKNWVYPEELEKVKEQISI---EPINVLEVEDIKEARKTLAKY--TPLKQAVLY 275 Query: 296 RLG-FGVKKTMMMAQRLYEA----GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 + K+T + AQ+LYE G I+Y RTDST LSQ +N+ R YI + FG++Y+ + Sbjct: 276 KKSPLTSKQTQIAAQKLYEGYGDGGLISYPRTDSTRLSQHFLNIARSYIKNKFGEEYILQ 335 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLK---DMEADAQKLYQLIWRQFVACQMTPAK 407 +A Q+AHEAIRP+D+N++ E K +++ +Y+LI+ + + P Sbjct: 336 EIKGFAG---DQDAHEAIRPTDINLLPEVAKAKFNLDNSEYIVYKLIYEHTLMSLINPPI 392 Query: 408 YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 + T T KA F G+ V + +ED P + ++E Sbjct: 393 KANKTYTFKKNKLTFKANVSKTIFPGYYLV----KNENEDIEDPNYQIQQKVDVLEYQIT 448 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 H TKPPAR++E SL++ L+ +GRPST+A+ ++ +R Y ++ + + G +V Sbjct: 449 NHETKPPARYTEGSLIEALDNIKVGRPSTFATTVAVNLERKYFENIDKSLHHTEFGRLVL 508 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 +L + F +++N +TA++E LD +A+++ + ++ F+ F + + A + E + Sbjct: 509 SKLLDGFPDIINEGYTAEVEEQLDLIASNKTTVQPIMYDFWKRFNKTYENATETLELIAI 568 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTA--STGVFLGCSGY 622 + + CP G ++ +R + F+GC+ + Sbjct: 569 ---ALEYLNEKCPDDGGELIVRNNKRNDTKFVGCANF 602 >UniRef50_B1M9R9 DNA topoisomerase I n=4 Tax=root RepID=B1M9R9_METRJ Length = 788 Score = 311 bits (796), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 253/814 (31%), Positives = 374/814 (45%), Gaps = 105/814 (12%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L++VESP K +I YLG D+ V +S GHIRDLP K D + P+K Sbjct: 3 LMVVESPNKVASIQGYLGDDWKVVASSGHIRDLPQREFGISKP-DFSLQYEYIPPQK--- 58 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 + PG V+ +K+ KAD +YLATD DREGEAI+WHL+ Sbjct: 59 ----------------VGNKTFPGAADRVARIKREVAKADAVYLATDPDREGEAISWHLK 102 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 E + + Y RV F EIT AI+ A +++D V+AQ+ RR +DR VGYMVSPLL Sbjct: 103 EALQLGEDDYERVTFTEITPKAIQAALRAARRIDMDLVHAQEGRRALDRFVGYMVSPLLS 162 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ--- 241 + LSAGRVQSVAVRLVV+ ER I AF + + + +G + Q + Sbjct: 163 DMLGMNLSAGRVQSVAVRLVVDLERRIAAFKSTKHFSAVVTFDAGAGAKWSAQWDTKPYV 222 Query: 242 -NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 D P+ V E A S + ++ VLE + + + +P +P T + +AAST L Sbjct: 223 TEDSPY--VLDEALAAKAS--QSRQFVVLESKTEEKSERPPSPLSTLGMLRAASTALKMS 278 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 T AQ+L+E G+ITY+RTDS NLS DA + VR + + G PE ++ K + Sbjct: 279 SAATTKAAQKLFEDGHITYIRTDSVNLSPDAADKVRSFAASQ-GMALSPEV-RRWKEKAS 336 Query: 361 SQEAH-EAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD 419 +Q H +A+RP+ + V D + + LY+LI + + QM A+Y T+ + A D Sbjct: 337 AQGGHADAVRPTHIEVEDAGADDAQ---RALYRLIRLRTLVSQMADARYTVNTVRLRATD 393 Query: 420 ---FRLKARGRILRFDGWTKVMPALRKGDE----------DRILPAVNKGDALTLVELTP 466 F ARGR + GW ++ R DE D +P + G L ++ Sbjct: 394 RDGFEYVARGRKMIDAGWRALLE--RDPDEEENSDDDAAKDGQVPRLAVGGDLRAIDGKV 451 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR-FYAEKMGEI 525 T+PP RF+EA+L+++LE G+GRP+T+A+I++ + R YV ++ +R ++GE+ Sbjct: 452 LDKKTEPPRRFTEATLLQKLEDEGVGRPATFAAIMTNVLGRSYVELDKKRCLLPTEIGEL 511 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 V D L M FT ++E LD +A +A ++ V++ + ++L + E Sbjct: 512 VVDNLLRGQFGFMELGFTRELEVQLDAIAEGKASYRDVVEPAYRQLNEELARIAVSGE-- 569 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKE---RCKTTINLVPENEV 642 CP CG G+R YA P K RC E E Sbjct: 570 -------FTPRFKCPKCG--TGMRR-----------YAKPGKSPFWRC------TAEAET 603 Query: 643 LNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIK 702 +D R CP+CG + + KRK + G C E + Sbjct: 604 CGHYMDDDKGKPVERTAHPCPRCGETLRRF----KRK-NGGGLVWVCPAEACETFLDDVG 658 Query: 703 GYDGPIVECEKCGS----------EMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 G + C KC + E G FG + CT+ E N + + + K Sbjct: 659 GKPVALHTCTKCNAPLRRYQKKDRETGKPTGAFGWF--CTDTE--NCKTFMDDD-----K 709 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTF 786 PV + PC K R G G + + + Sbjct: 710 GRPVAIKTAPCPKCGKAMYRRKGDHGFWWGCSGY 743 >UniRef50_C2KTI6 DNA topoisomerase n=2 Tax=Mobiluncus mulieris RepID=C2KTI6_9ACTO Length = 1032 Score = 305 bits (781), Expect = 6e-81, Method: Compositional matrix adjust. Identities = 197/459 (42%), Positives = 261/459 (56%), Gaps = 66/459 (14%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 + LVIVESPAKAKTI+++LG+DY V++SVGHIRDL + A+ T AK Sbjct: 32 RKLVIVESPAKAKTISRFLGNDYDVEASVGHIRDL---AQPSDLPAELKKTGYAK----- 83 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 VD +++E +Y V K+K VS+LK + A ++LATD DREGEAIAWH Sbjct: 84 --------FAVDLDNDFEPYYVVDADKKKKVSDLKARLKDASELFLATDEDREGEAIAWH 135 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L EV+ R+VF+EITK+AI A P +L+ D VNAQ+ARR +DR+VGY VSPL Sbjct: 136 LLEVLK-PKVPVKRMVFHEITKDAIDAALAHPRDLDQDLVNAQEARRILDRLVGYEVSPL 194 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV-------------------- 222 LW+KI GLSAGRVQSVA RLVV+RERE AF P E+W++ Sbjct: 195 LWRKIRTGLSAGRVQSVATRLVVDRERERIAFKPAEYWDLVATLQAPHETGANGITGSGS 254 Query: 223 -----DASTTTPSGEALALQVTHQNDKPFRPVNKEQ-----TQAAVSLLEK------ARY 266 DA+ T G+ +A +D P + +QAAV+ L + A + Sbjct: 255 NDPTFDATLKTLDGKRVATGKDLGDDGKLTPAAQRAGVVVLSQAAVTRLGEVFGAPGATW 314 Query: 267 SVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTN 326 V E E KP +P APF TS+LQQ AS +L + TM +AQ LYE GYITYMRTDS N Sbjct: 315 IVTEVESKPYRRRPPAPFTTSSLQQEASRKLRMNSRDTMRVAQTLYENGYITYMRTDSVN 374 Query: 327 LSQDAVNMVRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD--- 382 LS A++ R FG +P P +Y +K + +QEAHEAIRP+ E +D Sbjct: 375 LSDQAIHAARSLAVARFGADSVPAKPRRYETKAKGAQEAHEAIRPA-----GEHFRDPAS 429 Query: 383 ----MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA 417 + +LY LI+++ +ACQM A ++T+ V A Sbjct: 430 LQGTLTPGEWRLYHLIYQRTLACQMVDATGTTSTVHVEA 468 Score = 102 bits (255), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 56/122 (45%), Positives = 74/122 (60%), Gaps = 3/122 (2%) Query: 450 LPAVNKGDALTLVELTPA---QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506 LP + + L L+ L + QHFT PPARF++A+LVK +E+RGIGRPSTYAS ISTI D Sbjct: 587 LPRLAPREPLNLIHLDFSKERQHFTTPPARFTDATLVKAMEERGIGRPSTYASTISTIVD 646 Query: 507 RGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 R YV + + V LEEN L+++DFTA ME LD++A + A L Sbjct: 647 RSYVYRRGQALVPSWLAFSVVRLLEENLPGLVDFDFTADMETDLDKIAAGDGNRSAWLRD 706 Query: 567 FF 568 F+ Sbjct: 707 FW 708 >UniRef50_A3M2F6 TraB protein n=2 Tax=Acinetobacter baumannii ATCC 17978 RepID=A3M2F6_ACIBT Length = 753 Score = 296 bits (759), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 223/714 (31%), Positives = 335/714 (46%), Gaps = 132/714 (18%) Query: 5 LVIVESPAKAKTINKYLGS-----DYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKP 59 LVIVES K +I YL S + V S GHIRDLP Sbjct: 4 LVIVESSNKVDSIQGYLDSLFGRGKFKVSFSKGHIRDLP--------------------- 42 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 KD G + +Y V ELK L EK+ +YLATD DREGEAI Sbjct: 43 -KDSLGLTAE---------YTPNYVFNDSGASRVRELKALVEKSQKVYLATDPDREGEAI 92 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 AWHL+ V+ ++ Y RV F EITK A+ QA +LN+ V AQ+ RR +DR++GY+ Sbjct: 93 AWHLKTVLRLNE-NYGRVTFQEITKTAVAQAMGNERKLNMQVVQAQETRRILDRIIGYIG 151 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVP-------------EEFWEVDAST 226 +P AGRVQS V +V+ E +IK F +E WE T Sbjct: 152 TPAFTLICGEKQIAGRVQSSIVWYLVDLENKIKQFSSVLHFGVTFNFGSVDESWEAKWDT 211 Query: 227 TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFIT 286 + +T + PF ++++ + L E ++V E+KP S P APF T Sbjct: 212 SNF--------ITKLD--PF-VIDRKLAEEVSKLRE---FTVETFEEKPEKSSPPAPFTT 257 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 T +AA +L K+ M +AQ+L+E G+ITY+RTDS NLS DA+ +R + N K Sbjct: 258 PTYLRAAHVQLKLKTKRAMEIAQKLFEDGHITYIRTDSPNLSDDAIQAIREFALKN--KL 315 Query: 347 YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPA 406 +P +P ++ SK +QE HEAIRP+D N + S ++ Q +YQ+IW + VACQ+ A Sbjct: 316 PIPATPRKFKSKALAQEGHEAIRPTDFNQLKVS---DDSTIQAVYQMIWLRSVACQLDDA 372 Query: 407 KYDSTTL------TVGAGDFRLKARGRILRFDGWTKVMPALRKGDE-------------D 447 + + + V + +KARGR L GW ++ L ++ + Sbjct: 373 TFTARIVRMKGRQLVQGREVFVKARGRKLIDQGWLRLTAKLNFSEDENEDIPEDAAQELN 432 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 +P + K L ++ + T+PP R SEASL+K +E GIGRPST+ SI+S I D Sbjct: 433 NPVPLLQKAGNLVALKSDLNEKRTEPPRRHSEASLIKFMEDVGIGRPSTFVSIVSKIIDH 492 Query: 508 GYVRVENR-RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 GYV ++++ + +A + + + ++ F E N +TA++E LD +A+ E K +L Sbjct: 493 GYVHLDSKNKIHATDLAQRLVGKISNQF-EFCNLKYTAELEGKLDLIAHGENIGKRLLKE 551 Query: 567 FFSDFTQQLDKAEKDPEEGG----------------------------MRPNQMVLT--- 595 Q ++ K+ ++GG ++ M++ Sbjct: 552 THLKIETQAKESIKNLDQGGPKQYCSKCSEQLVNMTSANGKPYFKCTNLKCGHMMMNQDG 611 Query: 596 -SID---------CPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPE 639 +ID C C + R+ G F GCSG+ + +C + P+ Sbjct: 612 IAIDRESLTSEFKCIVCESGLISRSGQNGEFFGCSGF-FKKRNKCTASYQKKPD 664 >UniRef50_C3SA84 DNA topoisomerase n=1 Tax=Brachypodium distachyon RepID=C3SA84_BRADI Length = 856 Score = 285 bits (729), Expect = 5e-75, Method: Compositional matrix adjust. Identities = 219/712 (30%), Positives = 328/712 (46%), Gaps = 169/712 (23%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 + K++V+VES KAK I KYLG Y V S GH+RDL A KS + + Sbjct: 67 IAKSVVVVESATKAKVIQKYLGDMYEVLPSYGHVRDL------AGKS---------RSVR 111 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 D+ ++V + W + ++ L G E ++ LA+D DREGEAIA Sbjct: 112 PDDDFSMVWEVPSAAWTHLKSIRVALKGAENLI--------------LASDPDREGEAIA 157 Query: 121 WHLREVIG-----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 WH++E++ G +RVVF+EIT++AI+ A P +++D VNA ARR +D ++ Sbjct: 158 WHIKEMLEQQKALGCHVTVARVVFHEITEDAIKNALMFPRYIDMDLVNAYLARRSLDYLI 217 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA-----STTTPS 230 G+ +SPLLW+K+ SAGRVQS A+ LV +RE EI+ F P+E+W VD + + Sbjct: 218 GFGISPLLWRKLPGCRSAGRVQSAALALVSDRETEIEQFSPQEYWTVDTDFKIRCSDSSK 277 Query: 231 GEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 G L ++ H N K Q ++S E+AR Sbjct: 278 GLCLTSRIKHLNSKKL-------DQLSISSQEEAR------------------------- 305 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISD 341 A R+ +AQ+LYE G ITY+RTD ++S A VR + + Sbjct: 306 -AIEKRI---YSSQFEVAQKLYEGISLSSEEATGLITYLRTDGFHISDGAAEDVRSLVKE 361 Query: 342 NFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 +G++Y E +Y K +N+QEAHEAIRP+ S++ + L+ + W + Sbjct: 362 RYGEQYASEDVRKYLKKVKNAQEAHEAIRPT-------SIRRLPFAYNFLWCVFWDRGWE 414 Query: 401 CQMTPAKYDSTTLTVG--AGDFRLKARGRILRFDGWTKVM--------------PALRKG 444 +M Y + +G GD + L F G+ V AL Sbjct: 415 LKMVLGAYCHIQVDIGNPGGDMTFHSSASKLDFKGYQAVYDDTEASGSSENPEGEALHH- 473 Query: 445 DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTI 504 D L + D ++ V + QHFTKPP+R+SE +L+K+LE+ GIGRPSTYASI+ + Sbjct: 474 DNFEALSKLEMKDLVSPVNVHLGQHFTKPPSRYSEGALIKKLEELGIGRPSTYASIMRVL 533 Query: 505 QDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN---------------- 548 QDR YV +++R + E G +V+ L +F E+ +Y FTA ME Sbjct: 534 QDRKYVTIKSRVLHPEFRGRMVSAFLSHHFSEIADYSFTANMETEYGFRNQLKLAVYCHG 593 Query: 549 -------------------------SLDQVANHEAEWKAVLDHFFSDFTQ------QLD- 576 LD V+ EWK +L ++ F++ Q D Sbjct: 594 ISRYEIPGNQQVGKLVPREVRQQWLELDNVSAGSTEWKGLLKDYWERFSKYCGDASQWDV 653 Query: 577 -KAEKDPEEGGMRPNQMVLTSID-----CPTCGR---KMGIRTASTGVFLGC 619 K E+ EE RP ++ +D CP+C + + G F+GC Sbjct: 654 RKVERMLEE-KFRP--ILFPDLDDASRICPSCSEGTLRFKVSRFGEGYFIGC 702 >UniRef50_Q4AA55 DNA topoisomerase n=5 Tax=Mycoplasma hyopneumoniae RepID=Q4AA55_MYCHJ Length = 636 Score = 278 bits (710), Expect = 9e-73, Method: Compositional matrix adjust. Identities = 198/642 (30%), Positives = 322/642 (50%), Gaps = 62/642 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+IVESP K TI+ YL S Y V + VGHI +L +G Sbjct: 4 LIIVESPNKINTISSYLDSSYKVTACVGHITNLAKTGQFG-------------------- 43 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +G+D + W Y + K+K + E+K+LA++A + +ATD DREGEAI L Sbjct: 44 ------LGID-INTWTPSYVLDKTKKKTIDEIKKLAKQAKTVIIATDADREGEAIGASLV 96 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 E + D +Y R+ +NEITK AI +A PGELN + +N+QQ RR +DR++G+ ++ LL Sbjct: 97 EHLAITD-KYQRIKYNEITKTAILEALENPGELNQNLINSQQTRRMLDRIIGFRLTALLK 155 Query: 185 KKIA---RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEAL-ALQVTH 240 KI + +AGRVQS A+ L+ +RE+EI+ F+PE+++ ++ +G + Sbjct: 156 NKIKNPPKNPAAGRVQSFALSLIFDREKEIREFIPEKYFNLEVKINDENGNFFDTIYCNQ 215 Query: 241 QND-KPFRPVN-KEQTQAAVSLLEKARYSVLEREDKPTTSKPGA-PFITSTLQQAASTRL 297 QN+ K +N +E+ ++ +++ Y + ++ K T P P +T+ + S Sbjct: 216 QNEAKKVNWINSEEELSEIIAEIKENPYLIFKKYSKATRKDPKVIPLKQATIFKKMSQYS 275 Query: 298 GFGVKKTMMMAQRLYEA----GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 V + Q+LYE G I+Y RTDST LSQ + + +I NFG KY +S Sbjct: 276 SASVSNAL---QKLYEGYGDYGLISYPRTDSTRLSQTFIEKGKEFIIKNFGPKYFTKSIK 332 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ---KLYQLIWRQFVACQMTPAKYDS 410 +A Q+AHEAIRP+++ + E ++ Q ++YQLI++ + M + Sbjct: 333 GFAG---DQDAHEAIRPTNLELSPELAREKYHLGQIEFQIYQLIYQTTIQALMRSPERKI 389 Query: 411 TTLTVGA--GDFRLKARGRILRFDGWTKVM--PALRK----GDEDRILPAVNKGDALTLV 462 T LT D FDG+ K P+L+ D + ++ + D Sbjct: 390 TNLTFKTPIKDHIFSYSYSEFTFDGYYKATEKPSLKFKPEFSDIESLISKKFQVDKNFDN 449 Query: 463 ELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKM 522 + + H TKPPA F + +L+++L+ +GRPST+A + ++D YV E++ Sbjct: 450 SIKSSLHQTKPPAHFRDGTLIEKLDDEKVGRPSTFAISVKKLKDHLYVDSESKSLVLSDF 509 Query: 523 GEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDP 582 G+IV + L+ E+++ FTAQ+E LD +A + ++K LD +S ++KA + Sbjct: 510 GKIVYENLKIISPEIIDAKFTAQVEEELDLIAQGKQDYKKYLDSMWSKIENTIEKA-VEV 568 Query: 583 EEGGMRPNQMVLTSIDCPTCGRKMGIRT--ASTGVFLGCSGY 622 E+ M T C C + R + F+GCS + Sbjct: 569 EKVIMEART---TGEKCTECDADLVYRYNRKTNQRFIGCSSF 607 >UniRef50_UPI0001924CDD PREDICTED: similar to DNA topoisomerase I n=1 Tax=Hydra magnipapillata RepID=UPI0001924CDD Length = 819 Score = 255 bits (651), Expect = 5e-66, Method: Compositional matrix adjust. Identities = 203/684 (29%), Positives = 305/684 (44%), Gaps = 155/684 (22%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESP K K + LG YVV SS GHI DL PKK Sbjct: 57 LVIVESPGKIKKLESILGPGYVVTSSFGHIMDL--------------------HPKK--- 93 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEK------VVSELKQLAEKADHIYLATDLDREGEA 118 + +D +N+ Y ++ G +K VV ELK+ KA + +A D DREGE Sbjct: 94 ------LSIDLDNNFMPEYHIVTGTKKFQDKINVVKELKEKVSKASKVIIAADHDREGEM 147 Query: 119 IAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELN------------IDRVNAQQ 166 I W + + D Y R+ FN ITK +++A P +L+ +DR+ + Sbjct: 148 IGWSYKVALRLGDDDYERITFNSITKEEVKKAIANPRKLDMLMVDSQKTRRILDRIVGFR 207 Query: 167 ARRFMDRVVGY----------MVSPLLWKK--------------IARGLSAGRVQSVAVR 202 +++V+G +V+ L+ +K + +S ++ A+ Sbjct: 208 ISPGLNQVIGMRNLSAGRVQSIVTKLICEKEQEINKFFEGTNSSFFKAISDMNTENHAIN 267 Query: 203 LVVEREREIKAFVP--------------EEFWEVDASTTTPSGEALALQVTHQNDKPFRP 248 + E ++ + E+ ++D T ++ K + Sbjct: 268 MKCELYTDLPQCIEDIEDVEDIEDVEDIEDVEDIDEDTDNDEKSEKTTKMKRAVIKSLK- 326 Query: 249 VNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMA 308 N E+ +L ++ RE K P APF TST QQ ST+LGF VK+TM Sbjct: 327 -NAEKLMKNFTLSTFKVTNIYVRESKRF---PPAPFTTSTAQQDMSTKLGFNVKRTMTSL 382 Query: 309 QRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAI 368 Q+LYEAGY TY+RTDSTNLS+DA+ YI +N+G+KY N K N+QEAHEAI Sbjct: 383 QKLYEAGYTTYLRTDSTNLSKDALQQCEKYIKENYGEKYY-NLKNYMNKKGNTQEAHEAI 441 Query: 369 RPSDVNVM-AESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGR 427 RP D+ ++ + D Q++YQL+W++ VA QM PA + + +G + Sbjct: 442 RPVDITKKEIKTSGKIGPDEQRVYQLVWKRTVASQMAPANINVHYVEIGISKEKNYVFKA 501 Query: 428 ILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLV---ELTPAQHFTKPPARFSEASLVK 484 I+ +D I P LT V E+ ++ + KPP R+SEA LVK Sbjct: 502 II----------------DDIIFPGF-----LTTVLAKEIKFSEEYKKPPPRYSEAGLVK 540 Query: 485 ELEKR--GIGRPSTYASIISTIQDRGYVRV------------------------------ 512 +++ + IGRP+TYA II+T+Q R YV + Sbjct: 541 KMDPKNLNIGRPATYAEIINTVQKRNYVEIKDIDGIKKNSTILTWSPEDKNGVVIDKKTI 600 Query: 513 ----ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 E ++F ++G V L NF E+M Y FTA ME LD++A+ +W L+ F+ Sbjct: 601 YIGNEKKKFVPTQLGIEVNAILIRNFPEIMEYQFTANMEKELDEIADGGKKWIDCLETFW 660 Query: 569 SD---FTQQLDKAEKDPEEGGMRP 589 ++LD +K + G P Sbjct: 661 KKLKPLVEKLDTEKKAVKILGKNP 684 >UniRef50_D1HI22 DNA topoisomerase (Fragment) n=1 Tax=Vitis vinifera RepID=D1HI22_VITVI Length = 1035 Score = 253 bits (645), Expect = 3e-65, Method: Compositional matrix adjust. Identities = 162/458 (35%), Positives = 246/458 (53%), Gaps = 74/458 (16%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPT-SGSAAKKSADSTSTKTAKKPK 60 GK++V+VES KAK I YLG Y V S GH+RDL SGS + Sbjct: 93 GKSVVVVESVTKAKVIQGYLGDMYEVLPSYGHVRDLAGRSGSV----------------R 136 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 D+ ++V + W + ++ L G E ++ LA+D DREGEAIA Sbjct: 137 PDDDFSMVWEVPSAAWTHLKSIKVALGGAENLI--------------LASDPDREGEAIA 182 Query: 121 WHLREVIGGDDARY-----SRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 WH+ E++ DA + +RVVF+EIT+++I+ A + P E++++ V+A ARR +D ++ Sbjct: 183 WHIIEMLLQQDALHKDLTVARVVFHEITESSIKSALDAPREIDVNLVHAYLARRALDYLI 242 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALA 235 G+ +SPLLW+K+ SAGRVQS A+ L+ +RE EI F P+E+W V+ + + S A Sbjct: 243 GFNISPLLWRKLPGCQSAGRVQSAALALICDREMEIDEFKPQEYWTVELNQFSISSHTEA 302 Query: 236 LQVTHQ-NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 + + N F+ + ++ + R++ PT P+ITSTLQQ A+ Sbjct: 303 KAIEQEINSLEFKVIGSKRNKM--------------RKNPPT------PYITSTLQQDAA 342 Query: 295 TRLGFGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 +L F TM +AQRLYE AG ITYMRTD ++S +A +R +++ +G Sbjct: 343 NKLHFSAMYTMKLAQRLYEGVQLSDGKAAGLITYMRTDGLHVSDEAAKDIRSLVAERYGS 402 Query: 346 KYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQM 403 + +Y K +N+QEAHEAIRP+D+ + L ++ D+ KLY LIW + +ACQM Sbjct: 403 NLASDGVRKYFKKVKNAQEAHEAIRPTDIQRLPSMLAGVLDEDSLKLYTLIWSRTMACQM 462 Query: 404 TPAKYDSTTLTVGAGD----FRLKARGRILRFDGWTKV 437 PA D + +G + FR G + F G+ V Sbjct: 463 EPATIDQIQVDIGNANESVVFRSTCSG--VEFFGYQAV 498 Score = 124 bits (312), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 82/230 (35%), Positives = 120/230 (52%), Gaps = 27/230 (11%) Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 +G+ + L ++ GD L L L QH T PP+R+SE +LVK+LE+ GIGRPSTYA + Sbjct: 662 RGEVFKALSSLKAGDPLYLSLLELEQHHTLPPSRYSEGALVKKLEELGIGRPSTYAITMK 721 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 +QDR YV V+NR Y E G +V+ L +F E+ +Y FTA ME LD V+ EWK Sbjct: 722 VLQDRNYVTVKNRVLYPEFRGRMVSAFLSHHFSEVTDYSFTADMETELDNVSAGLTEWKG 781 Query: 563 VLDHFFSDFTQ--------QLDKAEKDPEE--GGMRPNQMVLTSIDCPTCGRKMGIRTAS 612 +L +++ F+ + + EK E+ G + + S CP+C I S Sbjct: 782 LLKDYWTRFSMYCNRVSNVHIHQVEKMLEKKFGDFLFSFLPDKSRTCPSCMEGTLIFKVS 841 Query: 613 ---TGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAK 659 +G F+GC + PK CK + +L+G+D E A + K Sbjct: 842 RFGSGYFIGCDQH---PK--CKY---------IAKMLDGDDDEEVASQDK 877 >UniRef50_Q2SR72 DNA topoisomerase n=4 Tax=Mollicutes RepID=Q2SR72_MYCCT Length = 643 Score = 238 bits (608), Expect = 5e-61, Method: Compositional matrix adjust. Identities = 175/653 (26%), Positives = 312/653 (47%), Gaps = 77/653 (11%) Query: 3 KALVIVESPAKAKTINKYLG-----SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAK 57 K LV++ESP+K + I YL +++VV +S GHI + G+ Sbjct: 2 KVLVLLESPSKIEKIKHYLEESFPENEFVVLASGGHINSIADKGAWG------------- 48 Query: 58 KPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGE 117 +G+D + ++ + ++K++S++K+ + AD I LA+D DREGE Sbjct: 49 -------------LGID-LETMQPNFVIESSRKKIISQIKKEGKTADLIILASDPDREGE 94 Query: 118 AIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGY 177 AIA+HL + D R+ FNEIT AI AFN +++++ VNAQ +R+ +D+++GY Sbjct: 95 AIAYHLANLFK-DHTNIKRITFNEITSEAITNAFNNLRDIDMNLVNAQISRQILDKIIGY 153 Query: 178 MVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAF---VPEEFWEVDASTTTPSGEAL 234 +VS L K +SAGRVQ+ A+ ++ R+ IK F + ++ + +++ Sbjct: 154 LVSKSLQKSTGL-MSAGRVQTPALNILTTRDTLIKNFKEVLYKKIFVIESKRAINLNLNK 212 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 N + +++ Q + V L + Y + + ++ P+ T+ L Q Sbjct: 213 DKNNVLVNTEKTYYIDENQAKTIVDELGEI-YRCTDYKSTAYETRSFKPYSTAGLLQDGF 271 Query: 295 TRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 T+L + + AQ+LYE GYITY+RTDS S + V+ YIS N+ L + P Sbjct: 272 TKLKLSTSQITLAAQKLYELGYITYIRTDSVKYSSQFIGEVKDYISKNYSSD-LFKDPIV 330 Query: 355 YASKENSQEAHEAIRPSDVNVMAE--SLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 +NSQEAHE+IRP+++ + E SL+ + +++Y LIW + M + Sbjct: 331 GKKDQNSQEAHESIRPTNIWLTPEKASLEIEDNLLKRVYNLIWWNSIKSLMKGPSGFNHR 390 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTL----------- 461 T + K + ++ G+ A++ D + + G+ + Sbjct: 391 WTFNNNGYEFKQSWQEVKDLGY----QAIKHSSSDENIELTDDGEEIVQSKNDKPEYQFN 446 Query: 462 --VELTPAQHF-------TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 E++ ++ F T PP F++ASL+KEL+ GIGRPSTY I++ ++DR YV Sbjct: 447 DDFEISISKKFIKIESAKTNPPKMFNQASLIKELKNLGIGRPSTYNPILTKLKDREYVEY 506 Query: 513 -ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 +++ G + L +++ + N ++TA+ME LD++ + ++ L + ++ Sbjct: 507 PKSKPIVVTNKGYSANEYLYDHYLDFFNLNYTAEMEEKLDEITRGDFDYVNWLKNIYNAL 566 Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYAL 624 ++ K E G + + CP CG + + GCS + + Sbjct: 567 NFKVKK------EIGEAKTEAI-----CPRCGANLVYIKSRFNRGRGCSNFTI 608 >UniRef50_UPI0001C41D8C DNA topoisomerase I TopA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41D8C Length = 741 Score = 237 bits (605), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 200/733 (27%), Positives = 343/733 (46%), Gaps = 97/733 (13%) Query: 22 GSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEA 81 G V S+VGH+ L ++ S +R+G D W Sbjct: 42 GKKTTVLSAVGHLYSLTSASSR-------------------------DRLGFD--LTWVP 74 Query: 82 HYEVLPGK--EKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDA--RYSRV 137 YEV K ++ +K+L++ AD A D D EG I ++ + G++A + SR+ Sbjct: 75 AYEVEKQKYTRDYINAIKKLSKGADKFVHACDYDVEGTLIGYNALKYACGNNAEAKASRM 134 Query: 138 VFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG------L 191 F+ +TK I +A+N +++I +V+ AR +D G +S L K + L Sbjct: 135 KFSTLTKKDIVEAYNTMRDIDIRQVDHGIARHMLDYYYGMNISSALMKAVRASSSRFISL 194 Query: 192 SAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNK 251 SAGRVQ+ + ++V+RE+EI++FVPE +W + A + + H K F ++ Sbjct: 195 SAGRVQTPTLSILVDREKEIQSFVPEPYWMIKAKSD------YDIIADHVEGKIF---DE 245 Query: 252 EQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRL 311 E+ + + + A V + + KP PF LQ A T GF K+T + AQ L Sbjct: 246 ERAKKIYADCQGADADVTSVKVTESIRKPPIPFNLGGLQSEAHTVFGFSPKRTQVAAQNL 305 Query: 312 YEAGYITYMRTDSTNL--SQDAVNMVRGYISDNFGKKYLPESPNQYASKEN--SQEAHEA 367 Y GY +Y RT S L S D N+ G D KK++ + P + E + AH A Sbjct: 306 YVGGYTSYPRTSSQKLPESLDFKNIFAGLAKDPEFKKHIFDLPAKLKPNEGKKTDAAHPA 365 Query: 368 IRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGR 427 I P+ V ++ AD K+Y LI +F++ +K ++ + + D + + Sbjct: 366 IHPTGV-----LPSNLSADEAKIYSLIVYRFISVFSENSKLETMKVNLKVADEKFTFSRK 420 Query: 428 ILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE 487 + ++GW K P K E+ P +NKGD L + ++ + TKPPAR++EASL+KELE Sbjct: 421 RVSYEGWLKHYPF--KKQENDAFPPINKGDQLKIHKILVEEKETKPPARYNEASLIKELE 478 Query: 488 KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQME 547 KR +G +T A I++ + DR Y +E ++ + +G + D L E ++L + + T + E Sbjct: 479 KRELGTKATRADIVAKLYDRKY--IEGKKIEVKPLGINIIDTLNEYCKDLTSEELTREFE 536 Query: 548 NSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR---PNQMVLTSIDCPTCGR 604 L+ + + + +L++ + L + ++ ++ G + Q +C +CG Sbjct: 537 RELEGIDTDKYTKEQILENGEKEVKTILAEINQNKKQIGEKLYGAYQETNVVGEC-SCGG 595 Query: 605 KMGIRTA--STGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRC 662 K+ R + + F+GCS + +CK T +L +L K+ C Sbjct: 596 KLIKRYSPRTKNTFVGCSNFP-----KCKVTYSLPKGANML---------------KKTC 635 Query: 663 PKCGTAMDSY-LIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV--ECEKCGSEMH 719 P CG M S K + HVC ++ C G ++ + P V +C +CG ++ Sbjct: 636 PTCGLPMISIKKASGKGRDHVCLDS-NC-GKDVSRRQ-------APEVVGKCPECGKDLL 686 Query: 720 LKMGRFGKYMACT 732 + GR+G+++ C+ Sbjct: 687 KRSGRYGEFVGCS 699 >UniRef50_UPI00006DC642 hypothetical protein CdifQ_04001409 n=1 Tax=Clostridium difficile QCD-32g58 RepID=UPI00006DC642 Length = 363 Score = 235 bits (599), Expect = 6e-60, Method: Compositional matrix adjust. Identities = 145/390 (37%), Positives = 202/390 (51%), Gaps = 46/390 (11%) Query: 362 QEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF 420 Q+AHEAIRP+ V+ ES+K + D KLY LIWR+FVA QM + +D + GD Sbjct: 13 QDAHEAIRPTSVDRTPESIKASLSKDQYKLYNLIWRRFVASQMEDSVFDILNVECKIGDI 72 Query: 421 RLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEA 480 KA G ++FDG+TKV + ED+ILP++ KGD L + + P QHFT+PPAR++EA Sbjct: 73 VFKATGSKMKFDGYTKVYNFSER--EDKILPSIEKGDILNIENILPDQHFTQPPARYTEA 130 Query: 481 SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY 540 SLVK LE+ GIGRPSTYA I+TI +R YV + ++G IVTD LE NF + ++ Sbjct: 131 SLVKTLEELGIGRPSTYAPTIATILNREYVEKQGTSLCPTELGIIVTDILENNFHKFIDV 190 Query: 541 DFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP 600 DFTA ME+ LD + +WK ++ ++ + +++A ++ E+ M T C Sbjct: 191 DFTADMESKLDVIEEGNTDWKKIVSESYAPLKEAIEEALENIEKVNMDEE----TDEICE 246 Query: 601 TCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKR 660 CG M I+ G F+ C Y CKTT ++N + Sbjct: 247 NCGSNMVIKYGRFGKFMACKNYP-----DCKTT------RPIMN------------KIGV 283 Query: 661 RCPKCGTAMDSYLIDPKR--KLHVCGNNPTCD--GYEIEEGEFRIKGYDGPIVECEKCGS 716 +CPKC D L KR + C N P CD + GEF CEKCGS Sbjct: 284 KCPKCEEG-DIILRKSKRGKAFYGCSNYPNCDFVAWNKPTGEF-----------CEKCGS 331 Query: 717 EMHLKMGRFGKYMACTNEECKNTRKILRNG 746 M K+ + C+N+EC K +G Sbjct: 332 YMVEKVTKSETKTVCSNKECNKETKEHNDG 361 >UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae RepID=TOP1_METTH Length = 718 Score = 231 bits (589), Expect = 9e-59, Method: Compositional matrix adjust. Identities = 193/668 (28%), Positives = 319/668 (47%), Gaps = 97/668 (14%) Query: 96 LKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDA--RYSRVVFNEITKNAIRQAFNK 153 +++ A AD A D D EG I ++ + G++A + SR+ F+ +T+ I++A+ Sbjct: 98 IRKFAAGADRYIHACDYDIEGTLIGFNALKYGCGEEALRKTSRMKFSTLTREEIQRAYKN 157 Query: 154 PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVER 207 P E++ +V++ AR +D + G +S L K + LSAGRVQ+ + ++VER Sbjct: 158 PIEVDYGQVDSGAARHILDFIFGVNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVER 217 Query: 208 EREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYS 267 E+EI+ F P +W + A GE + + + K F+ + S+LEK + S Sbjct: 218 EKEIRDFKPVPYWIIRAEL----GEGIIAE--SKRGKIFK------RELVDSILEKCQGS 265 Query: 268 VLERED---KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDS 324 E +D + T KP PF TLQ A GF KKT +AQ LY GY +Y RT S Sbjct: 266 DAEVKDVRVRDTIRKPPVPFDLGTLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSS 325 Query: 325 TNLSQD-AVNMVRGYISDN--FG----KKYLPESPNQYASKENSQEAHEAIRPSDVNVMA 377 L + + ++ N FG + P P++ KE+ +AH AI P+ + Sbjct: 326 QKLPESIGYEKILKNLAKNPRFGVHIERLRGPLKPHE-GKKED--DAHPAIHPTGL---- 378 Query: 378 ESLKDMEADAQKLYQLIWRQFVACQMTPAKYDS--TTLTVGAGDFRLKARGRILRFDGWT 435 ++ D +K+Y LI +F++ A + L +G +F +R R+ + GW Sbjct: 379 -LPSELSKDEKKVYDLIVHRFISVFGEDAILQTMKVELEIGEEEFSF-SRKRVSK-AGWM 435 Query: 436 KVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPS 495 + P + DE+ P ++ GD+L + ++ + TKPPAR++EASL++ELE+RG+G S Sbjct: 436 ESYPYTKMEDEE--FPEISGGDSLAVRSVSADERETKPPARYNEASLIRELERRGLGTKS 493 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 T A II+ + DR Y +E ++ +GE + D L ++++ + T Q E L+ + Sbjct: 494 TRADIIAKLYDRKY--IEGKKIRVSPLGENIIDTLTRYCEKIISEELTRQFERELEDIMR 551 Query: 556 HEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG---MRPNQMVLTSIDCPTCGRKMGIRTA- 611 + V+D ++ L E++ + G R Q +CP CG K+ I+ + Sbjct: 552 GKISKDRVIDEAITEVRSILSDIEENLRDIGKELYRAYQDSRVVGECPACGGKLVIKYSP 611 Query: 612 -STGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMD 670 + F+GCS Y C+T +L VL L C KCG M Sbjct: 612 RNRSTFVGCSSYP-----DCRTVYSLPRGASVLKSL---------------CEKCGLPMI 651 Query: 671 SY-------LIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMG 723 SY +DPK CG + E+EE + +C +CGS++ + G Sbjct: 652 SYGRPRQRACLDPK-----CGKKKS----EVEE----------VVGKCPECGSDLIKRSG 692 Query: 724 RFGKYMAC 731 R+G+++ C Sbjct: 693 RYGEFVGC 700 >UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepID=TOP1_METJA Length = 761 Score = 230 bits (587), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 198/703 (28%), Positives = 328/703 (46%), Gaps = 76/703 (10%) Query: 88 GKE---KVVSELKQLAEKADHIYLATDLDREGEAIAWH-LREVIGGDDARYSRVVFNEIT 143 GKE K + LK+L++ AD Y+ATD D EGE I +H L+ G + A+ R+ F+ +T Sbjct: 85 GKEYVNKYIKALKKLSKDADEFYIATDWDIEGELIGYHALKYCCGREKAK--RMRFSSLT 142 Query: 144 KNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-----RGLSAGRVQS 198 K I +AF P E++ V+A ++R +D G +S L I + +S GRVQ Sbjct: 143 KKEIVRAFENPDEIDYGLVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQG 202 Query: 199 VAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAV 258 A+ + ERE EIK F+P+ +W ++A L+ H+ +K + KE Sbjct: 203 PALAFLTERELEIKKFIPKPYWVIEALLKD------NLKAIHEKEKFWN--EKEAKNVYE 254 Query: 259 SLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT 318 + ++ V+E + KP PF TLQ+ A + K+T +AQ+LYE I+ Sbjct: 255 KIKDEKSAKVVEIKKTKRKLKPLPPFDLGTLQREAYSYFKISPKETQEIAQKLYENALIS 314 Query: 319 YMRTDSTNLS------QDAVNMVRGY-ISDNFGKKYLPESPNQYASKENSQEAHEAIRPS 371 Y RT S L +D +N+++ + + + ++ L E+ K+ AH AI Sbjct: 315 YPRTSSQKLPKDRKYLEDILNIIKNHPVYGKWAERILKENLKPVEGKKEDP-AHPAIHIV 373 Query: 372 DVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRF 431 D+ S +++Y LI R+ +A A+ + + + + K G Sbjct: 374 DIPKEELS-----EKEKEIYDLIARRTLAAFWDNAEREYLNVKIDIKGEKFKLSGSRTVK 428 Query: 432 DGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGI 491 +GW ++ K DE LP + K D + + ++T + T+PP R++ AS++KELEKRG+ Sbjct: 429 EGWHEIY-YFPKFDEIE-LPPLKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKRGL 486 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G +T A II + RGYV +++ +G V + L+ E+++ T +E L+ Sbjct: 487 GTKATRAEIIDKLIKRGYV-IDDGSLKVTDLGISVIETLKRFCPEIIDEKMTRDLEEKLE 545 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR-------PNQMVLTSIDCPTCGR 604 ++ + + VLD + L++ +K E+ G+ N+ CP CG Sbjct: 546 KIQFRKIKKDDVLDEAEKRLRKILEEFKKKEEDIGIYLIKNLDATNKKAKIVGKCPKCGG 605 Query: 605 KMGIRTASTGVFLGCSG-------YALPPKER----------CKTTINLVPENEVLNVLE 647 + + G F+GCS Y+LP K R CK+ I + + E+ E Sbjct: 606 DLILIRHKKGRFVGCSNYPECDVKYSLPDKGRIKIPNKVCDACKSPILKIGDREICINPE 665 Query: 648 GEDAETNALRAKRRCPKCGTAMDSYLIDPK---RKLHVCGNNPTCDGYE-IEEGEFRIKG 703 + R CPKCG LI K + C N P C E I + E Sbjct: 666 CPLKQVEVKEEDRICPKCGAK----LILKKGVYGAFYGCSNYPKCKYTEPINKKEV---- 717 Query: 704 YDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRN 745 + +C KCG ++ ++ G+FGK++ C+N +C+ T K+ N Sbjct: 718 ----VGKCPKCGGDLVVREGKFGKFVGCSNYPKCRYTEKLKLN 756 >UniRef50_B0SF59 DNA topoisomerase n=3 Tax=Leptospira biflexa RepID=B0SF59_LEPBA Length = 625 Score = 226 bits (577), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 193/686 (28%), Positives = 309/686 (45%), Gaps = 88/686 (12%) Query: 26 VVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEV 85 +V ++ GHI+DLP PK GVD + +E YE Sbjct: 1 MVVATKGHIKDLP--------------------PK---------SYGVDLSNQFEPEYEW 31 Query: 86 LPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKN 145 L GK+ + + + A+K IY+A+D DREGE IA H + + R+ EITK Sbjct: 32 LKGKKSLFTTITTKAKKCSLIYIASDPDREGEIIAKHCFDELSKLKKPIYRLRLKEITKE 91 Query: 146 AIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI-ARGLSAGRVQSVAVRLV 204 ++ K L+ + +Q ARR +DR+ G+ VSP LWK + LSAGRVQS + + Sbjct: 92 ELQSQIQKKIGLDQQEIESQIARRVIDRIFGFEVSPDLWKHLKIPSLSAGRVQSTVLHWI 151 Query: 205 VEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRP------VNKEQTQAAV 258 ERE+EI+ F E ++++ T +++ +Q+ + + +N+ Q Sbjct: 152 CEREKEIQNFSKENYFQLKLIGTLNEN---PIELKYQSKEKLKQEEIQTILNEIQILPDP 208 Query: 259 SLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE----- 313 S L+ S L+ K P F T++L +++ L F KKTM +AQ L+E Sbjct: 209 SRLKNIVLSNLKI--KKIKRNPPKAFSTASLLESSFRALQFDSKKTMRLAQSLFEGKKLH 266 Query: 314 ----AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIR 369 G ITYMR+DST +S+ ++ Y+ +++ S NQ K+ SQ+AHEAI Sbjct: 267 AGETVGLITYMRSDSTRVSESKQDLGEKYLKEHYPNLLWEGSRNQGKQKKFSQDAHEAIT 326 Query: 370 PSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRI 428 P + ++ E +K + D KLYQLIW +F+ + P + G + Sbjct: 327 PINPSLSPEQIKSFLTLDEWKLYQLIWERFLTSLLKPEIGEEIVYEFPIGKHIFEHSFET 386 Query: 429 LRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK 488 + G+ K P ++ E L A GD + + T+PP R+++ L++++E Sbjct: 387 ISDPGF-KNFPRPKEKREKISLNA-KIGDLFFYESYSVEEKETEPPQRYTQGKLIQKMED 444 Query: 489 RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN 548 G+GRPSTYA+I+ T++ R Y+ + ++G V L NF +L+ FT +E+ Sbjct: 445 TGVGRPSTYATILETLKLRKYIVEYKKNIGPSQLGLKVDSYLFLNFFDLIGESFTKDLES 504 Query: 549 SLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGI 608 LDQ+ + +A ++ +F+ Q L K G V D Sbjct: 505 KLDQITDEKASRVKLVANFYDQLKQILKSPRKKMVSIGKENQSKVKYDTDEK-------- 556 Query: 609 RTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 +T S V G E+ T N +N+ L +E + CPKC Sbjct: 557 QTLSEKVKNGKGS------EKKGNTKN---QNQSLTYIEN-----------KTCPKC--- 593 Query: 669 MDSY----LIDPKRKLHVCGNNPTCD 690 +D Y L + ++ C P CD Sbjct: 594 LDGYVKTKLGKNGKTIYFCSRYPHCD 619 >UniRef50_C9R890 Reverse gyrase n=1 Tax=Ammonifex degensii KC4 RepID=C9R890_AMMDK Length = 1143 Score = 222 bits (565), Expect = 5e-56, Method: Compositional matrix adjust. Identities = 186/609 (30%), Positives = 292/609 (47%), Gaps = 96/609 (15%) Query: 4 ALVIVESPAKAKTINKYLGS-------------------DYVVKSSVGHIRDLPTSGSAA 44 ALV+VESP KA+TI + G ++ +S+GH+ +L S Sbjct: 580 ALVVVESPHKARTIASFWGKPGIRRVKGVLAYEIPADERHLIITASLGHVFNL----SRQ 635 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMG---VDPWHNWEAHYEVLPGKEKVVSELKQLAE 101 + + P D + G VDP + K++++ L+ LA Sbjct: 636 QGFFGVLTFNHHFLPVFDTI-KIYRETGEELVDPEEVARYPEGTVWDKQEILRGLQHLAF 694 Query: 102 KADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDR 161 + D +Y+A+D D EGE IA+ L + + R+ F+E+T +A R+A PG++N+ R Sbjct: 695 EVDEVYIASDPDAEGEKIAYDLYLSLRPFNPHIYRLEFHEVTPSAFRRALENPGQVNLYR 754 Query: 162 VNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 V AQ RR +DR VG+ +S LW+K R LSAGRVQ+ + VV R EE Sbjct: 755 VQAQLTRRVLDRWVGFCLSRRLWQKFGNRHLSAGRVQTPVLGWVVARA--------EEGR 806 Query: 221 EVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 + A T GEA T + P ++E Q LEK + +LE ++ + P Sbjct: 807 QRKARLTFSLGEA-----TFTLEVP----DRELGQKIFGELEKLSWEILEISEEERSPLP 857 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMV-RGYI 339 PF T T+ A+ RL TM + Q L+E G+ITY RTDST +S+ +V + +I Sbjct: 858 --PFTTDTILTEAAHRLRLSAPVTMKLLQELFELGFITYHRTDSTRVSETGRFLVAKPFI 915 Query: 340 SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAE-------SLKDMEAD-AQKLY 391 ++G++ P + AHEAIRP+ AE L D+ + A +LY Sbjct: 916 LQHYGEELF--HPRSWGEG----GAHEAIRPTRPMTEAELRWMVGAGLVDLSQERALELY 969 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILP 451 LI+R+F+A QM PA+ K R R+ + T+V ++ Sbjct: 970 GLIFRRFMASQMAPARVRKA-----------KVRFRVPSYAWETEV-----------VVE 1007 Query: 452 AVNKGDAL-----TLVELTPAQHFTKPPAR-------FSEASLVKELEKRGIGRPSTYAS 499 + G AL ++ EL P T R ++E +LV+E++++GIGRPSTYA Sbjct: 1008 QIAPGFALLWPNFSVTELRPEARLTGKEYRELPLAEPYTEGTLVQEMKRQGIGRPSTYAE 1067 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 I++T+ +RGY+ V R Y ++G V L+ENF E + T ++E ++D +A + + Sbjct: 1068 IVATLLNRGYLVVRGGRLYPTRLGFKVYRYLKENFPEYADTALTREIEAAMDLIAEGKED 1127 Query: 560 WKAVLDHFF 568 ++ VL + Sbjct: 1128 YQEVLQKLY 1136 >UniRef50_B9LRP1 DNA topoisomerase n=4 Tax=Halobacteriaceae RepID=B9LRP1_HALLT Length = 864 Score = 221 bits (563), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 212/723 (29%), Positives = 333/723 (46%), Gaps = 99/723 (13%) Query: 87 PGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG--GDDARYSRVVFNEITK 144 P +E +V+ L++LA A + +ATD DREGE I E++ +DA RV F+ IT Sbjct: 82 PTQEGIVAALRKLARNASRVVIATDYDREGELIGKEAYELVREVNEDAPIDRVRFSSITD 141 Query: 145 NAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGL-----SAGRVQSV 199 N + +AF P EL+ D A +AR+ +D G ++ L AR L S GRVQ Sbjct: 142 NEVNEAFANPDELDFDLAAAGEARQVIDLTWGAALTRFL-SLSARQLGEDFISVGRVQGP 200 Query: 200 AVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND---KPFRPVNKEQTQA 256 ++L+V+REREIKAF PE +WE+ + T G+ + + ND + R N + + Sbjct: 201 TLKLIVDREREIKAFDPEAYWELYGNLTKSGGDPFEARYFYLNDEGNEAERVWNGDVAEV 260 Query: 257 AVSLLEKARYSVLEREDKPT-TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG 315 + A +V++ + T T P PF T+ +AA + LG ++ M +A+ LY AG Sbjct: 261 LTEAFDAADEAVVDDVRRRTRTDDPPTPFNTTAFIRAAGS-LGHSAQRAMSLAEDLYTAG 319 Query: 316 YITYMRTDSTNLSQ--DAVNMVRGY-ISDNFGK--KYLPESPNQYASKENSQEA--HEAI 368 Y+TY RTD+T + D ++ ++ FGK K L E + E +E H I Sbjct: 320 YVTYPRTDNTVYPEDLDPRELIEELSVASTFGKDAKSLLEQ-EEIEPTEGDEETTDHPPI 378 Query: 369 RPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLT-------------- 414 P+ S D+ D ++Y+LI R+F+A PA ++ + Sbjct: 379 HPTG---ELPSASDLSEDEWEVYELIVRRFLATCAEPATWERLRVVALANDEATAIAERA 435 Query: 415 ------------------VGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKG 456 V G RLKA G+ L G+ V P R DE RI+P V G Sbjct: 436 DGLAALRNPEEASGPGDLVADGGLRLKANGKRLLEAGYHDVYP-YRSSDE-RIVPDVEVG 493 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 + L L + T+PP R+ ++ L++E+EKRG+G +T + + DR Y+ + R Sbjct: 494 ETLALTDRRTDAKETQPPRRYGQSRLIEEMEKRGVGTKATRHRTLEKLYDRNYIESDPPR 553 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV-------LDHFFS 569 ++ E V + EE +++ + TAQ+E + +A E + V L+ F Sbjct: 554 --PTRLAEAVVEAAEEFAEHVVSEEMTAQLERDMQAIAAGEKGYDEVTEASRELLNRVFD 611 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG-VFLGCSGYALPPKE 628 D T+ +A D + ++ ++ T CP CG + +R + G F+GC GY Sbjct: 612 DLTESR-EAVGDHLQKSLKADK---TLGPCPECGSDLLVRKSRQGSYFVGCDGYP----- 662 Query: 629 RCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPT 688 C+ T+ L + L L E E + LR + L K +H C P Sbjct: 663 DCEYTLPLPSSGKPL--LLDETCEEHELRHVK-----------MLAGRKTFVHGC---PQ 706 Query: 689 CDGYEIEEGEFRIKGYDGPIVEC-EKCGSEMHLKMGRFG-KYMACTN-EECKNTRKILRN 745 C E +E E + G EC E+ G E+ +K R G + + CT +C + + R Sbjct: 707 CKADEADEQEDEVI---GACPECGEEHGGELAIKRLRSGSRLVGCTRYPDCDYSLPLPRR 763 Query: 746 GEV 748 GE+ Sbjct: 764 GEI 766 >UniRef50_A6Q5V5 Reverse gyrase n=30 Tax=cellular organisms RepID=A6Q5V5_NITSB Length = 1118 Score = 209 bits (532), Expect = 3e-52, Method: Compositional matrix adjust. Identities = 177/592 (29%), Positives = 289/592 (48%), Gaps = 71/592 (11%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 +LVIVESP KA+TI + G V +G IR + K T++K + + Sbjct: 578 SLVIVESPNKARTIANFYGKPMV--RDLGGIRVYEVAKEG--KILSITASKGHVVDLQKQ 633 Query: 64 RGALVNRMGVDPWHNWEAHYE-VLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 G GV ++ +E + K +++ L+++ + +Y+ATD D EGE I++ Sbjct: 634 EGV----YGVLRQEHFIPLFEPIDENKRRIIEALRRIGVEVQDVYIATDPDVEGEKISYD 689 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L+ + + R F+E+TK A +A + P + + + V AQ RR DR +G+ +S + Sbjct: 690 LQLLTKPYNHTVQRAEFHEVTKRAFDEALSHPRDFDENLVKAQLVRRIADRWIGFSLSQM 749 Query: 183 LWKKIARG-LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 L KK+ + LSAGRVQS + +V RE+E K E+ + V S E Sbjct: 750 LQKKLQKSWLSAGRVQSAVLEWIVLREKEAK----EKIFVVHVSFRGLEAE--------- 796 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 F K++ + LE +++E K PF T + AAS+ L F Sbjct: 797 ----FVFDEKQKAKDFYERLEVVEVRFIQKETKELFR---TPFTTDAMLYAASSELHFSP 849 Query: 302 KKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL-PESPNQYASKEN 360 +KTM +AQ L+E+G+ITY RTDST +S + + + YI FG+ Y P S ++ Sbjct: 850 QKTMQLAQDLFESGFITYHRTDSTRISSVGIAIAKEYIQSRFGQDYFVPRSHSKAGG--- 906 Query: 361 SQEAHEAIRPS---DVNVMAESLK----DMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 AHEAIRP+ D + + L+ ++ D KLY LI++ F+A QM AK + Sbjct: 907 ---AHEAIRPTKAMDAQELEQFLQMQNSNLTQDHLKLYDLIFKNFIASQMKSAKIEEIAA 963 Query: 414 TVGAGDFRLKARGRILRF------DGWTKVMPA-LRKGDEDRILPAVNKGDALTLVELTP 466 V A D + +RF G ++P L + E R AV K + LT Sbjct: 964 QVEAFD-----QKTTIRFYDEIVEHGIDLILPVQLHQLQEGRY--AVQK-ELLTR----- 1010 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 +K P ++S A +++ +++RGIGRPSTYA I +Q+R Y+ Y K+G+ V Sbjct: 1011 ----SKVP-KYSYADVIRLMKERGIGRPSTYAITIQKLQERHYIVQRRGILYPTKLGQEV 1065 Query: 527 TDRLEEN--FRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 + L +N +N +T ++E +D+V E ++ V++ + ++++ Sbjct: 1066 YEELRKNPEVYTFVNEHYTKELEALMDRVEKGEVSYEEVVESLYLQLKERIE 1117 >UniRef50_O67226 Topoisomerase n=3 Tax=cellular organisms RepID=RGYR2_AQUAE Length = 1159 Score = 206 bits (525), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 172/604 (28%), Positives = 280/604 (46%), Gaps = 93/604 (15%) Query: 4 ALVIVESPAKAKTINKYLGSD-------------------YVVKSSVGHIRDLPTSGSAA 44 LVIVESP KA+TI + G V+ +S+GH+ DL T Sbjct: 588 TLVIVESPNKARTIAGFFGKPQMRLVEDSVAYEVPLGDRLLVITASLGHVLDLVTDKGFF 647 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLP--------GKEKVVSEL 96 D+ K R H YE L K +++ + Sbjct: 648 GVLDDTYPYLPVYDTIKICRET----------HEQHTEYEYLKKRCKGKIEDKLEIIKGV 697 Query: 97 KQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE 156 ++++ + D +++ATD D EGE I + L + + R F+E+T A R+A P E Sbjct: 698 REVSYEVDEVFIATDPDAEGEKIGYDLYLLSKPFNFNIKRAEFHEVTPKAFREAIQNPRE 757 Query: 157 LNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREIKAFV 215 ++++ V AQ RR +DR VG+ +S +LW + LSAGRVQ+ + V++R E K Sbjct: 758 VDLNLVKAQLVRRILDRWVGFTLSHILWDAFGKKWLSAGRVQTPVLGWVIKRYEESKE-- 815 Query: 216 PEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSL---LEKARYSVLERE 272 GE L H ND P + + E A + LE A S+ + Sbjct: 816 -------------KKGEIL----LHVNDFPLK-IEIEDLMFAKEIFKDLELADISLSNPQ 857 Query: 273 DKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV 332 ++ +P P+ T T+ + A+ +L KTM + Q L+EAGYITY RTDST +S Sbjct: 858 EE--EKRPLPPYTTDTVLEDANEKLHLSAHKTMKILQELFEAGYITYHRTDSTRVSDAGK 915 Query: 333 NMV-RGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPS------DVNVMAES----LK 381 +V + YI+ FG++Y Y AHE IRP+ D+ M + + Sbjct: 916 YLVAKPYITKMFGEEYF------YPRSWGEGGAHECIRPTRPLEPKDLEFMITAGIAEFE 969 Query: 382 DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPAL 441 D E +A K+Y+LI+++F+A QM PAK + + + F K R V+ + Sbjct: 970 DPE-NALKVYELIFKRFMASQMRPAKVITEEIILKLPYFEWKER-----------VVTEV 1017 Query: 442 RKGDEDRILPAVNKGDALTLVELTPAQHFTKPPAR-FSEASLVKELEKRGIGRPSTYASI 500 ++ D + P +E+T + P +++ +L++E+++RG+GRPSTYA I Sbjct: 1018 KEHGFDLMYPTFKVFPKKEKLEITHKEFREVPKVYPYTQGTLIQEMKRRGLGRPSTYAQI 1077 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 + T+ +R YV E +G V + L ++F E + + T ++E ++D++ E ++ Sbjct: 1078 VQTLLERHYVVEEKGFLIPTDLGREVYEYLTKHFPEWTSEELTRKLEEAMDKIERGELDY 1137 Query: 561 KAVL 564 VL Sbjct: 1138 MEVL 1141 >UniRef50_Q18KP8 DNA topoisomerase n=6 Tax=Halobacteriaceae RepID=Q18KP8_HALWD Length = 857 Score = 205 bits (521), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 187/715 (26%), Positives = 325/715 (45%), Gaps = 76/715 (10%) Query: 73 VDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG--GD 130 V+P +A E P K+ +V+ LK+LA +A + +ATD DREGE I E++ + Sbjct: 68 VEPVELIDAPIEKNPTKQNIVTTLKKLARRARRVIIATDYDREGELIGKEAYELVRRVNE 127 Query: 131 DARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG 190 RV F+ IT+ ++ AF P +L+ + A +AR+ +D V G ++ L ++ G Sbjct: 128 STPIDRVRFSSITEESVTTAFENPDDLDFNLAAAGEARQVIDLVWGAALTRYL--SLSAG 185 Query: 191 ------LSAGRVQSVAVRLVVEREREIKAFVPEEFWE-----------VDASTTTPSGEA 233 +S GRVQ ++L+V+REREI+AF PE++WE ++ ST + E Sbjct: 186 QLGSDFISVGRVQGPTLKLIVDREREIEAFDPEDYWELFVDLTQADKPIEVSTDDTAAEF 245 Query: 234 LALQVTHQND--KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPT-TSKPGAPFITSTLQ 290 A H +D + R + + LE A + ++ + T T +P APF T+ Sbjct: 246 EAQYFYHADDGTEAERITEESTAKTVFETLESASIAHVDSVKRRTRTDEPPAPFNTTQFI 305 Query: 291 QAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVNMVRGYISDN-FG--- 344 AA + +G+ ++ M +A+ LY AGYITY RTD+T D ++ + + FG Sbjct: 306 SAAGS-IGYAAQRAMDIAEDLYTAGYITYPRTDNTVYPDELDPRELIEALTNGSRFGSDA 364 Query: 345 KKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMT 404 + L + + + H I P+D L D D ++Y+LI R F+A Sbjct: 365 RDVLDQETLSPTTGDEETTDHPPIHPTDELPKPSELDD---DKWEVYELIVRHFLATVSN 421 Query: 405 PAKYDSTTLTVGAGD-FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVE 463 PA ++ + D + +K+ GR L G+ V P + ++P + G+ L L++ Sbjct: 422 PATWEHLRIVAIVDDTYSIKSNGRRLLNPGYHAVYP--YSNATESLIPDIEDGETLRLID 479 Query: 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMG 523 T+PP R+ ++ L++ +E GIG S+ ++I + +RGY+ + R ++ Sbjct: 480 SRIEAKQTQPPRRYGQSRLIETMESMGIGTKSSRHNVIQKLYNRGYIESDPPR--PTQLA 537 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD---HFFSDFTQQLDKAEK 580 V + EE +++ + TAQ+E + +A E ++V +D ++L + Sbjct: 538 RAVVEAAEEFAELIVSEEMTAQLETDMQAIAEGEETLESVTSASRSILTDVFKKLMNTDA 597 Query: 581 DPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV-FLGCSGYALPPKERCKTTINLVPE 639 + + R + T CP C + R + G F+GC Y C+ T+ L P Sbjct: 598 EIGDHLQRSMKADKTIGPCPQCEGDLITRKSQAGSHFIGCDSYP-----DCEYTLPL-PS 651 Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF 699 ++LE C L + +H C P C+ +E Sbjct: 652 TGKPHILE------------TVCDVHNLQQIKMLAGKRSFVHGC---PLCEAEAADEQAD 696 Query: 700 RIKGYDGPIVECEKCGS----EMHLKMGRFG-KYMACTN-EECKNTRKILRNGEV 748 R+ G C +C + E+ +K R G + + CT +C+ + + R GE+ Sbjct: 697 RVIGT------CPECNAHADGELAIKRLRSGSRLVGCTRYPDCEYSLPLPRQGEI 745 >UniRef50_Q64CK3 DNA topoisomerase n=2 Tax=environmental samples RepID=Q64CK3_9ARCH Length = 681 Score = 204 bits (519), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 170/577 (29%), Positives = 294/577 (50%), Gaps = 43/577 (7%) Query: 69 NRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG 128 N VDP+ +A + K+ +V L Q+A+KAD+I +ATD DREGE I I Sbjct: 60 NWSKVDPYKLIDAKIVTVALKKDIVKTLGQIAKKADYITVATDYDREGELIGVEALNSIK 119 Query: 129 --GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS---PLL 183 + + R+ ++ IT+ I+ +F E++ + + + R+ +D V G ++ L Sbjct: 120 KINPELKVDRMRYSAITEKDIKDSFAARSEVDYNLAASAEVRQIIDLVWGASLTRFVSLS 179 Query: 184 WKKIARGL-SAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 ++ G S GRVQS + L+VE+E+EI FVP ++WE+ A T +GE VTH+ Sbjct: 180 ANRLGDGFFSVGRVQSPTLALLVEKEKEIAKFVPRKYWELHAKLKTENGEIF--DVTHKT 237 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLER-EDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 K + K++ + A + +E A+ + + K KP PF T+T +AAS + + Sbjct: 238 AKFW---EKDEAEVAKARIEAAKEGFVRTLKTKLRVEKPPTPFDTTTFIRAASA-ISYTP 293 Query: 302 KKTMMMAQRLYEAGYITYMRTDSTNL--SQDAVNMVRGYISDN-FGKKYLPESPNQY--- 355 K+ M +A+ LY G I+Y RTD+T + D +V+ + FGK + Sbjct: 294 KRLMAIAEGLYLGGLISYHRTDNTTYPDTLDLKALVQMFQKHKEFGKHAKLLLTKKELKP 353 Query: 356 -ASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 A K+ + + H I P +AE+ KD +E D K+Y+L+ R+F+A AK++ T + Sbjct: 354 TAGKKKTTD-HPPIHP-----VAETTKDKLEKDEWKVYELVVRRFLATLSDAAKWEDTNV 407 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKP 473 T GD L A+GR+L+ G+ + P +K E+ ++P + + + + L + + TKP Sbjct: 408 TAEIGDEPLTAKGRLLKEQGFLAIYPYQKK--EELVIPQLKEDEKVDLEHIELVEKETKP 465 Query: 474 PARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEEN 533 P R S+A L+K+++ G+G ST II + DR YV+ N EK ++ D LE+ Sbjct: 466 PNRISQAGLIKKMDDLGLGTKSTRHEIIGKLYDRTYVQ-GNPAKPTEKAVALI-DSLEKY 523 Query: 534 FRELMNYDFTAQMENSLDQVANHEAEWKAV-------LDHFFSDFTQQLDKAEKDPEEGG 586 + + T +E +++++ + + K V L F+D + + +E Sbjct: 524 AALITKSEMTKTLELEMNEISEGKRKKKEVAEDSRNMLKDVFADLKKNRSEIGNSLKE-A 582 Query: 587 MRPNQMVLTSIDCPTCGRKMGIRTASTGV-FLGCSGY 622 +R +++V + CP C + + ++ G F+GCS Y Sbjct: 583 VRADKIVGS---CPKCDSDLLLLSSRRGKRFVGCSNY 616 >UniRef50_C8WG68 DNA topoisomerase type IA central domain protein n=9 Tax=Coriobacteriaceae RepID=C8WG68_EGGLE Length = 849 Score = 204 bits (519), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 199/713 (27%), Positives = 318/713 (44%), Gaps = 98/713 (13%) Query: 86 LPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG--GDDARYSRVVFNEIT 143 LP +++++ LK LA+KAD + +ATD DREGE I I A SR ++ T Sbjct: 125 LPKEKEIIRSLKNLAKKADSVIIATDFDREGELIGSDALSCIQEVNPTAPVSRARYSAFT 184 Query: 144 KNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL----WKKIARGLSAGRVQSV 199 K I AF+ EL+++ +A +R+ +D + G +++ L + S+GRVQ+ Sbjct: 185 KEEITHAFDNLVELDVNLASAGASRQDIDLIWGAVLTRYLTLVKFAGYGNVRSSGRVQTP 244 Query: 200 AVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVS 259 + LVV RERE AFVPE++W + + + + + H + F+ + + QA ++ Sbjct: 245 TLALVVARERERLAFVPEDYWVIRGAF---GADPDSFEAPHATAR-FK--AEAEAQAVMA 298 Query: 260 LLEKA-RYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT 318 +E A R +V E K T +P APF T++L AAS G +TM +A+ LY GYI+ Sbjct: 299 HVEGATRATVASVEKKKRTVQPPAPFNTTSLMAAASAE-GLSPARTMRIAESLYMDGYIS 357 Query: 319 YMRTDSTNL--SQDAVNMVRGYISDN-----FGKKYLPESPNQYASKENSQEAHEAIRPS 371 Y R D+T S D + V+ IS N + K+ L + + H I P+ Sbjct: 358 YPRVDNTVYPSSLDLADTVKA-ISGNPAYAPYCKELLAKGKLTATRGKKETTDHPPIYPT 416 Query: 372 DVNVMAESLKDMEADAQ-KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILR 430 A++ D A A KLY LI R+F+A A + T +T+ A+G +L Sbjct: 417 -----AKATPDDLAPADYKLYNLIARRFLATLSEAAVIEGTKVTLDVNAEPFVAKGDVLV 471 Query: 431 FDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRG 490 G+ + P K DE LPA+++G+ + + T+PPAR+S+ L++E+EK G Sbjct: 472 KPGYRAIYPYGLKKDEQ--LPALSEGETVAFNGAVCTKKQTEPPARYSQGKLIQEMEKLG 529 Query: 491 IGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSL 550 +G ST +II + Y N ++G V D L++ + + + TA++E + Sbjct: 530 LGTKSTRHAIIERLYAVKYCM--NDPIEPSQLGMAVCDALDKFAPHITHPEMTAELEEEM 587 Query: 551 DQVANHEAEWKAVLD---HFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMG 607 D +A V+D + S+ L ++ +E CP CG+ + Sbjct: 588 DNIAEGRTTKAQVVDTSRNLLSEQLASLLPHSEEVKEALADAVAADAYVGPCPKCGKDLQ 647 Query: 608 IRTA--STGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKC 665 +R + + +F+GC+G+ C T L P+ +V V E CP C Sbjct: 648 LRASQKTRSMFIGCAGWP-----DCDVTYPL-PKGKVEAVPE-------------PCPTC 688 Query: 666 G------TAMDS----YLIDPKRKLH-----VCGNNPTCDGYEIEEGE------------ 698 G TA S IDP + V G P C I+ Sbjct: 689 GMPQVKVTAFRSKPRTICIDPHCSTNQEPDVVVGECPACKEKGIQAKLIAQKNPRTLKRF 748 Query: 699 FRIKGYDG-----PIVE----------CEKCGSEMHLKMGRFGKYMACTNEEC 736 R + YD P+ + CE CG+ M + G + C N +C Sbjct: 749 IRCENYDDCGTGYPLPQYGALTATEEVCEHCGAPMVIVTTARGPWKLCPNFDC 801 >UniRef50_B9LA13 Reverse gyrase n=14 Tax=cellular organisms RepID=B9LA13_NAUPA Length = 1072 Score = 202 bits (513), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 171/597 (28%), Positives = 282/597 (47%), Gaps = 104/597 (17%) Query: 4 ALVIVESPAKAKTINKYLGSD-------------------YVVKSSVGHIRDLPTSGSAA 44 + VIVESP KAKTI+ + G+ ++ +S+GH DL Sbjct: 546 SFVIVESPTKAKTISSFFGNPSKRIINNVAVYEVLSQDRVLIIAASIGHDFDLV------ 599 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD 104 KDE GV + + VL K+K++ L A + + Sbjct: 600 ----------------KDE--------GVWGVKDLIPIFHVLENKDKILQTLNINANEVE 635 Query: 105 HIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNA 164 +Y ATD DREGE IA+ L + + R+ F+EITK A +A + P E++++ V + Sbjct: 636 EVYAATDPDREGEKIAFDLTMINKPYNMNIKRIEFHEITKQAFEEALSIPREIDLNLVKS 695 Query: 165 QQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD 223 Q RR DR VG+ +S L + + LSAGRVQ+ ++ + ER + E+ + V Sbjct: 696 QLFRRITDRWVGFKISLYLQRLLNNTHLSAGRVQTPVLKWICER----TGLLKEKIYVVI 751 Query: 224 ASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 S + F K++ + L+++ Y +++ T P Sbjct: 752 IRFNNVSID-------------FEFDTKQEANEFFNSLKESVY--IKKLSSNTEVMFEKP 796 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNF 343 F T L + AS +L F +KTM +AQ L+E G+ITY RTDS +S + + YI +NF Sbjct: 797 FNTPDLLKEASNKLRFSPQKTMQLAQELFEKGFITYHRTDSYRISDTGKAIAKTYILENF 856 Query: 344 GKKYLPESPNQYASKENSQEAHEAIRPSDV-------NVMAESLKDMEADAQKLYQLIWR 396 K YL ++ + E S+ AHEAIR + + M E + + +LY LI+R Sbjct: 857 SKDYL-----KFRNFE-SKGAHEAIRATTSMDADELRSYMLERNILLSEEHLRLYDLIFR 910 Query: 397 QFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRF--DGWTKVMPALRKGDEDRILPAVN 454 +F+A QM AK + LK + I +G+ + P + ++ Sbjct: 911 KFIASQMKEAKVLKEKFLI-----LLKEKSFITEIVENGYNLIYPI--------NIYIIS 957 Query: 455 KGDALTLVELTPAQHFTKPPAR-FSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513 +G+ + EL KP A ++ A +++E+ +GIGRPSTYA II + R Y+ + Sbjct: 958 EGENKIVKELRQ-----KPKAAPYTYAEVIEEMRSKGIGRPSTYAIIIEKLLKRKYITDK 1012 Query: 514 NRRFYAEKMG-EIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 N +A K+G I+ + + +F++ ++ +FTA++EN +D++ + E++ L FS Sbjct: 1013 NGYLFATKLGFRIIKEVYKSDFKDFVSEEFTAELENIMDKIEEGKTEYEKELKKLFS 1069 >UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_GEOSY Length = 697 Score = 200 bits (508), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 196/697 (28%), Positives = 309/697 (44%), Gaps = 90/697 (12%) Query: 3 KALVIVESPAKAKTINKYLGSD-----------YVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ A+ I + LG Y+V ++GH+ +L +K Sbjct: 2 KSLVLAEKPSVARDIARVLGCKETHKPYFEGPRYIVTWALGHLVELKMPEDYDRKYETWR 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLA 109 PKK MG+ +V+ +++LA++ D + +A Sbjct: 62 LEDLPIIPKK---------MGL----------KVIRQTSHQFRAIERLAKRPDVKDVIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRV-NAQQ 166 TD REGE +A + E+IG + R+ + T AIR F KPG DR+ + Sbjct: 103 TDAGREGELVARWILEMIGWTKPIW-RLWISSQTDRAIRDGFRQLKPGA-QFDRLYQSAV 160 Query: 167 ARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 R D ++G VS L K LSAGRVQ+ + +++EREREI++FVP +W + A Sbjct: 161 CRAEADWLIGLNVSRALTTKYNDPLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKI 220 Query: 227 TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFIT 286 G A+ H + F ++++ + ++ L+ V+ + K + P+ Sbjct: 221 ----GSITAVWERHGGHRLF---DQDEAKQLLARLDGQPARVVSVKRKRKSEPAPLPYDL 273 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTNLSQDA--------VNMVRG 337 + LQ+ A+ R GF KKT+ + QRLYE +TY RTDS L D + M G Sbjct: 274 TELQRDANKRFGFSAKKTLSVLQRLYEQHKLVTYPRTDSRYLPSDMEATMTERLLAMKSG 333 Query: 338 YISDNFGKKYLPESPNQYASKENSQEA--HEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 Y D N + H AI P+D + +L + D +KLY LI Sbjct: 334 Y-EDVIAPLLAKGKAKAAKRVFNDDKVTDHHAIVPTDERL---NLSRLSTDERKLYDLIA 389 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNK 455 R+F+A P + ++TT G A+ + G+ V+ + D L + + Sbjct: 390 RRFLALFFPPYESETTTAVFDIGGEMFVAKETAVVNFGFKAVL-GKEETDAKPTLSHLAE 448 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 G L V+L Q FT+PPAR+SEA L+ ++EK G+G P+T A II + + V ++ Sbjct: 449 GQTLPSVQLEREQSFTEPPARYSEADLLAQMEKYGLGTPATRADIIERLVETEVVERKDG 508 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 RFY K G+ + + + E EL + + TA+ E L+ +A + + L + TQQL Sbjct: 509 RFYPTKKGKQLIELVNE---ELKSPELTARWERELEAIARGKGNPQQFLANIRRQ-TQQL 564 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 K E+ PN LT++ CP CG + R G L CS A + R + Sbjct: 565 VAEIKQSEQVYKAPN---LTNLTCPECGALLKERKTKDGRMLVCSNLACRYRRRRDPKL- 620 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSY 672 + RRCP+C M+ + Sbjct: 621 ----------------------SNRRCPQCHRRMEMH 635 >UniRef50_A1RXQ0 Reverse gyrase n=2 Tax=Archaea RepID=A1RXQ0_THEPD Length = 1283 Score = 200 bits (508), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 191/646 (29%), Positives = 309/646 (47%), Gaps = 98/646 (15%) Query: 4 ALVIVESPAKAKTINKYLG-----------------SDYV--VKSSVGHIRDLPTSGSAA 44 LV+VESP KA+TI + G S Y+ + ++ GHI DL T+ + Sbjct: 653 VLVVVESPTKARTIASFFGKPSRRRVGPLVAYDIAFSGYILTIVATQGHIFDLTTNAYSY 712 Query: 45 KKSAD--STSTKTAKKPKKDER--------------GALVNRMGVDP---WHNWEAHYEV 85 S D A K R GA V+ H + E Sbjct: 713 NSSKDLYGVLVLDAYGASKHYRFVPVFNTIKRCMNCGAQFTEYAVEDVPRQHVQKVEVEK 772 Query: 86 ---------LPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSR 136 + K ++V L++LA + + +++ATD D EGE IAW + + R Sbjct: 773 RCPRCGSTNVFDKAEIVEALRKLASEVEEVFVATDPDTEGEKIAWDVYLSLAPYVRVIKR 832 Query: 137 VVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG---LSA 193 V F+E+T+ A +A P +N V AQ RR DR +G+ +S L + RG LSA Sbjct: 833 VEFHEVTRRAFEEALRNPRSINDRMVEAQLVRRIEDRWLGFSLSQKLQE--CRGHKWLSA 890 Query: 194 GRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQ 253 GRVQ+ + +VE KA + + ++ S GE L + V + Q Sbjct: 891 GRVQTPVLGWIVENSE--KARRKKVVFILELSRRGAEGEKLRVIVDNARLDG-------Q 941 Query: 254 TQAAVS---LLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQR 310 + AAVS E S++ RE+K T P PF T TL + A+ LG V +TM +AQ Sbjct: 942 SPAAVSNKIKEEGVTVSIVSREEK--TLPPPPPFTTDTLLREANQVLGLDVDRTMRIAQD 999 Query: 311 LYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRP 370 L+E+G ITY RTDST +S +++ R YI++ F ++Y +P ++ AHE IRP Sbjct: 1000 LFESGLITYHRTDSTRVSDLGISVARTYITERFSEEYF--APRRWGEG----GAHECIRP 1053 Query: 371 S---DVNVMAESLK--------DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD 419 + DV+ + + ++ + D +LY LI+R+F+A QM PAK V Sbjct: 1054 TRPLDVDSLMQMIRQGILQVQVNFTRDHIRLYDLIFRRFIASQMPPAKVVEAKAVVKGPY 1113 Query: 420 FRLK---ARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPAR 476 F + I + +G+TK++P LR R +P K D L L+ + ++ P Sbjct: 1114 FEKEITFIESIIEKAEGFTKILP-LRT----RQIPE-GKYDVL----LSTYKRVSEVPL- 1162 Query: 477 FSEASLVKELEKRGIGRPSTYASIISTIQDRGY-VRVENRRFYAEKMGEIVTDRLEENFR 535 +++A +++ +++R IGRPSTY+ I+ T+ DR Y V V+ R + ++G+ V + L NF Sbjct: 1163 YTQADVIRLMKERNIGRPSTYSKIVRTLLDRNYVVEVKGGRLVSTRLGKKVYEFLSVNFG 1222 Query: 536 ELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 ++++ + TA + +D++ A++ VL F+ + ++ + D Sbjct: 1223 DVVSENKTADVLRRMDEIEEGRADYLDVLAEFYEEVQSKVIEKNAD 1268 >UniRef50_O67037 Topoisomerase n=11 Tax=cellular organisms RepID=RGYR1_AQUAE Length = 1146 Score = 198 bits (503), Expect = 9e-49, Method: Compositional matrix adjust. Identities = 176/581 (30%), Positives = 281/581 (48%), Gaps = 58/581 (9%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LV+VESP KA+TI + G + +G I L ++ K E Sbjct: 597 VLVVVESPNKARTIANFFGKP--MGRKIGGIDVLEVMVGDLYIMITASLGHVFDLVKDKE 654 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 ++ + G + YEV+ GKE +V L++LA++ D + + TD D EGE I W L Sbjct: 655 FHGVIAKNG-----EYVPIYEVIEGKENIVKGLRELAQEVDTVLIGTDPDTEGEKIGWDL 709 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 ++ R+ F+E+T+ AI+ A P + N + V AQ RR DR VG+ VS ++ Sbjct: 710 GALLSPYIPNVERIEFHEVTRKAIKHAVENPRDFNENLVKAQLVRRIADRWVGFEVSRIV 769 Query: 184 WKKIARG-LSAGRVQSVAVRLVVERE---REIKAFVPEEFWEVDASTTTPSGEALALQVT 239 + + LS GRVQ + ++ERE R+ K V F E +G L L Sbjct: 770 QQAFDKHWLSGGRVQIPVLGWIIEREKLYRKKKHVVQITFKE--------NGRWLRLGFE 821 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 Q+ KE + +L E V E++ P PF T T+ + AS R Sbjct: 822 FQD-------KKEAKEFYENLKE---IDVEVLEEREELKNPPPPFTTDTMLKEASDRYRI 871 Query: 300 GVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE 359 V K M +AQ L+E G ITY RTDST +S + + + +IS+ GK+ Y Sbjct: 872 SVPKLMQLAQELFEYGLITYHRTDSTRVSDVGIGVAKEWISEELGKELF------YPRVW 925 Query: 360 NSQEAHEAIRPS---DVN-----VMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 AHE IRP+ DV ++A L+++ + LY+LI+++F+A QM P K + Sbjct: 926 GEGGAHECIRPTKPLDVEDLRSMMLAGQLQNLTREHLLLYELIFKRFMASQMKPVKVKTK 985 Query: 412 TLTVGA--GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 + V A + L IL +G+ KV P + D + +K + ++ P + Sbjct: 986 KVKVKALGREQELILTTEILE-EGFNKVYPLELQPDLKGSVYVEDKKE----LKSVPMAY 1040 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 +++ SLV+E+++RGIGRPSTYA+I+S + +RGYV + K+G+ V + Sbjct: 1041 L------YTQGSLVEEMKRRGIGRPSTYATIVSKLLERGYVIERHGFLIPTKLGKQVYEF 1094 Query: 530 LE--ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 L+ E ++ +FT ++E +D+V + ++ VLD + Sbjct: 1095 LKSREKIMPFVSEEFTRKLEELMDKVEEGKEDYLQVLDELY 1135 >UniRef50_Q74MA4 Reverse gyrase n=1 Tax=Nanoarchaeum equitans RepID=Q74MA4_NANEQ Length = 701 Score = 198 bits (503), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 169/598 (28%), Positives = 279/598 (46%), Gaps = 79/598 (13%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L IVESP KA+TI + G V +G+I+ T+ + +T + K+E Sbjct: 42 VLFIVESPNKARTIANFFGKPSV--RRIGNIKAYETTTGKYILTIVATKGHLFELTLKEE 99 Query: 64 --RGALVNRMGV----------DPWHNWEAHYEVLP--GKEKV------VSELKQLAEKA 103 G L + V D H + + P G E + + L+ LA++A Sbjct: 100 GVYGVLKEKEYVPIFSPIKKCLDCGHQF-VDEDKCPRCGSENIDDASDRIKVLRDLAQEA 158 Query: 104 DHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVN 163 D + + TD D EGE IA+ + +I + R F+E+T+ AI +A + ++N +RV Sbjct: 159 DIVLIGTDPDAEGEKIAYDVYSIIRPYNKNIYRAEFHEVTRQAIIKALEEIRDINTNRVK 218 Query: 164 AQQARRFMDRVVGYMVSPLLWKKI-ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 AQ RR DR +G+ +S LW + + LSAGRVQ+ + +++R E K ++ V Sbjct: 219 AQLVRRIEDRWIGFALSQRLWSRFKKKTLSAGRVQTPVLGFIIKRYEEYKK-NRAHYYAV 277 Query: 223 DASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 S +VT +D P +K + +K + KP Sbjct: 278 KTSD---------FEVTFISDDPLEKYDKTIKIEKIE-------------EKESEKKPLP 315 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDN 342 P+ T +L + A L V K M +AQ L+E G ITY RTDST++S + + + YI + Sbjct: 316 PYTTDSLLRDAVIELRLSVDKIMALAQNLFEWGLITYHRTDSTHISNLGIQIAQTYIENT 375 Query: 343 FGKKYLPESPNQYASKENSQEAHEAIRPS---DVNVMAESLKDMEADAQ-------KLYQ 392 FGK+Y Y + HEAIRP+ D + + L++ + Q +LY Sbjct: 376 FGKEYF------YPRHWGEEGTHEAIRPTKPIDTETLIKMLREGDIQIQGITKEHIRLYD 429 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRI-LRFDGWTKVMPALRKGDEDRILP 451 LI+R+F+A QM P T + G ++ +GW + P L Sbjct: 430 LIFRRFIASQMKPFIAIETKFNAVWSNLNTTIEGITDIKENGWNLIKPIK--------LL 481 Query: 452 AVNKGDALTLVELTPAQHF--TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 A+ +G+ E+ +H+ +K P +++A +++ ++++ IGRPSTYA+I+ + +R Y Sbjct: 482 AIKEGEY----EVIDVKHWIGSKVPL-YTQADVIELMKEQNIGRPSTYATIVKKLFERYY 536 Query: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 V +N+R + G V L E F L++ TA + +D++ N E ++ VL F Sbjct: 537 VIEKNQRLIPTERGIKVYQYLTERFGHLVDVKLTADLLEKMDRIENGELDYMDVLRSF 594 >UniRef50_UPI0001698F80 DNA topoisomerase I n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698F80 Length = 424 Score = 196 bits (498), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 129/363 (35%), Positives = 192/363 (52%), Gaps = 50/363 (13%) Query: 376 MAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGW 434 + +KD + D +LY+LIW++ VACQM A T+ A D + G I R +G Sbjct: 4 LPTEIKDHLSKDQARLYELIWKRAVACQMIHA-----TIHTVAADLQC-GEGNIFRANGS 57 Query: 435 TKVMPAL-----------RKGDED-RILPAVNKGDALTLVELTPAQHFTKPPARFSEASL 482 T P KGD D ++LP + +G+ + L + P QHFT+PP RF+EASL Sbjct: 58 TIAKPGFIAVYMEGKDDAAKGDGDEKMLPPLQEGETVALKAIRPEQHFTEPPPRFTEASL 117 Query: 483 VKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDF 542 VK LE+ GIGRPSTYASIIST+QDR YV +E +RF +G +V L ++F + ++YDF Sbjct: 118 VKTLEEYGIGRPSTYASIISTLQDREYVTLEKKRFQPTDVGRVVNKFLTDHFTQYVDYDF 177 Query: 543 TAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID--CP 600 TA++E+ LD V+ E W +L+ F++ F +++D +++ ++ + + ++D CP Sbjct: 178 TAKLEDELDAVSRGEEAWVPLLERFWTPFKERIDYTQEN-----VKRSDVTHEALDEKCP 232 Query: 601 TCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKR 660 CG ++ IR G F+GC+ Y +C T + LN + E E + R Sbjct: 233 KCGDQLSIRLGRHGRFIGCNNYP-----KCDYTRD-------LNADKSEQDEPQVVEG-R 279 Query: 661 RCPKCGTAMDSYLIDPKR--KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEM 718 CP+CG+ + +I R K C P C E E K D V C KCG+ Sbjct: 280 SCPECGSPL---VIKRGRYGKFIGCSGYPNCRHIEPLE-----KPQDT-GVSCPKCGNGT 330 Query: 719 HLK 721 LK Sbjct: 331 LLK 333 >UniRef50_Q9ZKK4 Topoisomerase I n=9 Tax=Helicobacter RepID=Q9ZKK4_HELPJ Length = 686 Score = 196 bits (497), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 168/614 (27%), Positives = 287/614 (46%), Gaps = 78/614 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M +++I+ESP K I + G+ V +++GH L KS D + Sbjct: 1 MNNSVIIIESPNKVAKIREITGAK--VFATIGHFMQL--------KSYDENN-------- 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 G P +++ K+K + E+ + A K +Y+ATD DREG AI Sbjct: 43 -----------GFKPTFDYDQE------KKKHIFEMIE-ACKNKKVYIATDPDREGYAIG 84 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQ-----ARRFMDRVV 175 + + I + R F EIT + I + L + N Q ARR D ++ Sbjct: 85 YMFYQKIKNVASSIYRAEFFEITPSGINKGLQNA--LLFENTNRQMYQSALARRVADMLL 142 Query: 176 GYMVSPLLWKKIA--RGLSAGRVQSVAVRLVVEREREIKAF--VPEE---FWEVDASTTT 228 G+ +SP L K + +G SAGRVQ+ ++L+V+R+REI+ F +PE +++ A Sbjct: 143 GFTLSPYLGKALGQMKGSSAGRVQTPCLKLIVDRDREIEKFKALPENEKVSYQIQAKIND 202 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVL-EREDKPTTSKPGAPFITS 287 + + ++ + + + +KE+ L+ + +L + ++ +KP PFITS Sbjct: 203 SANREVTIKHCDEKGEEIKFNDKEEALKLFESLKDNKACLLKDLKNSVVETKPKKPFITS 262 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 TL + AS+ LG + + +AQ L+EAG ITY+RTD+ +LS + ++ + + + Y Sbjct: 263 TLLEKASSMLGLSISEVQSLAQNLFEAGLITYIRTDAESLSVEFLDETESFYAPIYKDLY 322 Query: 348 LPESPNQYASKENSQEAHEAIRPS------DVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 L A K++ EAHEAIR + D+ + + DA KLYQLI+ + + Sbjct: 323 LKREYK--AGKQSQAEAHEAIRITHPHTTEDLESIVYNANITNQDALKLYQLIFERTIES 380 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNK------ 455 Q A YD L + K + L+ G+ + +++ NK Sbjct: 381 QGKNAIYDKQDLLFKIKNEYFKCSVKGLKSAGFLAMFSKKELENDESNDDKDNKEKEQNA 440 Query: 456 ------GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 D L+L +L + P+ + EA VK LE +GIGRPSTYAS + T+ R Y Sbjct: 441 QFNLKIDDVLSLNDLVLSTIKRNAPSAYKEADFVKLLENKGIGRPSTYASYLPTLVKREY 500 Query: 510 VRVENRRFYA---EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 + + + + G+ V + E ++ +++ +T QME LD++ +++ + +D Sbjct: 501 ISISQDKKHIITPTHKGKRVVEVFENAYQFIIDLTYTKQMEEVLDEIVENKSSY---VD- 556 Query: 567 FFSDFTQQLDKAEK 580 F S+ + K EK Sbjct: 557 FISNLNSKCPKIEK 570 >UniRef50_UPI00019793DC topoisomerase I n=1 Tax=Helicobacter cinaedi CCUG 18818 RepID=UPI00019793DC Length = 632 Score = 194 bits (493), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 183/672 (27%), Positives = 311/672 (46%), Gaps = 99/672 (14%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+I+ESP K + I K G Y V +++GH DL + Sbjct: 3 LIIIESPNKVEKIKKITG--YEVIATIGHFMDLKS------------------------- 35 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 D +++ ++E K+K + Q A K +Y+A+D DREG +I + Sbjct: 36 --------FDIDKDYKPNFEYAESKKKRIMNAIQKA-KGQEVYIASDPDREGYSIGYMFF 86 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPG---ELNIDRVNAQQARRFMDRVVGYMVSP 181 E I ++ R F+EIT + I+Q + N + + ARR D+++G+++SP Sbjct: 87 EKIKNVASKIYRAEFHEITPSGIKQGLENAKLFVDTNFNYYQSFLARRVSDQLIGFLLSP 146 Query: 182 LLWKKIA--RGLSAGRVQSVAVRLVVEREREIKAFVP------EEFWEVDASTTTPSGEA 233 L K + + LSAGRVQ+ A+ L+ +RE+EIK F +EF V + + Sbjct: 147 YLTKSLQYNKMLSAGRVQTPALGLITKREQEIKDFAALSEEQKQEFGIV--ANANIDNKL 204 Query: 234 LALQVTHQNDKPFRPVNKEQTQAA---VSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 ++ + + K R +++ Q ++ ++KA +E + T+SKP PF TS L Sbjct: 205 ISFKHISDDLKELRFQTQQEAQNVCDEIASMDKALIDKIEINN--TSSKPAKPFTTSKLL 262 Query: 291 QAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 +AAS L K +AQ L+ AG ITY+RTDS +S + + ++ + Y+ Sbjct: 263 KAASKTLSLPTKDIQNLAQELFAAGLITYIRTDSEYISPEFLKEMQSF--------YVSI 314 Query: 351 SPNQY------ASKENSQEAHEAIRPSDVNVM--AESL---KDMEADAQKLYQLIWRQFV 399 PN Y A K + EAHEAIR + + ESL ++++ + LY+LI++ + Sbjct: 315 YPNTYQYTEYKAGKNSQAEAHEAIRITHCHRFEECESLCQKENLKDNHIALYKLIFQNTI 374 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM---PALRK-GDED-------- 447 Q PA Y++ +T+ K + L +G+ V A+ + GD + Sbjct: 375 LSQSKPAIYETMNVTLRVKMKMFKTSFKKLIDEGYLGVFGKNEAINENGDSENDESEESL 434 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 P +GD + L +++ P R+ EA ++ +EK IGRPSTYA+ + + ++ Sbjct: 435 HSFP-YKQGDMIALQDISIKSIKKSAPKRYLEADFIEVMEKSAIGRPSTYATFLPLLLNK 493 Query: 508 GYVRV---ENRRFYAEKMGEIVTDRL-EENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 Y+ + + R +G VT ++N L++ FT MEN LD++AN ++ Sbjct: 494 EYIEISKDKKREIIPTTLGMSVTQFFSKDNNAWLLDIAFTRDMENELDEIANSSKKYLDF 553 Query: 564 LDHFFSDFTQQLDKAE----KD--PEEGGMRPNQMVLTSIDCPTC-GRKMGIRTASTGVF 616 + S KAE KD P E ++ + + T+++ P G + R A F Sbjct: 554 MKTIHSKMNFMPLKAESKEKKDYPPSEKQIKFCKDISTTLNIPLPDGLEKDYRIARK--F 611 Query: 617 LGCSGYALPPKE 628 + + +P KE Sbjct: 612 IDENASKMPKKE 623 >UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP1_PYRHO Length = 686 Score = 192 bits (488), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 182/654 (27%), Positives = 294/654 (44%), Gaps = 79/654 (12%) Query: 22 GSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEA 81 G +V S+VGH+ L PK+D G + + W Sbjct: 41 GKKLIVASAVGHLYGL--------------------APKRDVFGYPIFDI------EWVP 74 Query: 82 HYEVLPGKE---KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYS-RV 137 Y GKE + + L LA++ +A D D EGE I + + G D R + R+ Sbjct: 75 VYIAEKGKEYAREYIKALSVLAKRVREFIVACDYDTEGEVIGYTALKYACGVDPRVAKRM 134 Query: 138 VFNEITKNAIRQAF-NKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG------ 190 F+ +TK + A+ N +N NA AR +D G +S L I + Sbjct: 135 KFSALTKRDLLNAWRNLEPTINFGMANAGIARHILDWYWGVNLSRALTHAIKKASGKWVV 194 Query: 191 LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVN 250 LS GRVQ ++ +VEREREI++FVP +W V +G+ ++ DK + Sbjct: 195 LSTGRVQGPTLKFLVEREREIQSFVPRPYW-VIKLIFEKNGQKFT--ANYEKDKIW---E 248 Query: 251 KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQR 310 +E+ + V ++K+ V E K P PF TLQ+ A + GF KKT+ +AQ Sbjct: 249 EEEGKRIVLEVKKSIPRVSNVEIKRQKRTPPHPFDLGTLQREAYSAFGFSPKKTLDIAQS 308 Query: 311 LYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGK--KY---------LPESPNQYASKE 359 LYE G+ +Y RT+S L + N+ I N K +Y LPE KE Sbjct: 309 LYEKGFSSYPRTESQKLPR---NINFRMIIQNLAKMPQYRPYAHILLGLPELKPVEGKKE 365 Query: 360 NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD 419 + AH AI P+ D+ D +KLY +I R+F+A M PA +S +T+ AG Sbjct: 366 DP--AHPAIYPTG---EIPRPGDLTKDEEKLYDMIVRRFLAVFMEPAIRESVKVTIRAGP 420 Query: 420 FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSE 479 + G GW V K +E LP G+ + ++++ + TKPPAR+S Sbjct: 421 HKFFLSGGRTVKKGWLSVYGKYVKFEEV-TLPEFFIGERIKVIQVKREKKKTKPPARYSP 479 Query: 480 ASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMN 539 A+++K++E G+G +T A I+ T+ RGY+ + +G V + LE+ E+++ Sbjct: 480 AAVIKKMEDLGLGTKATRAQILETLYQRGYIE-GKKSIKVTPLGMKVIETLEKYVPEIIS 538 Query: 540 YDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMV------ 593 + T + E ++ + + V++ T+ L++ +K E G+ ++V Sbjct: 539 VELTREFEKKMELIMEGRLTKEEVIEEAKERLTKILEEFKKRELEIGIELAKIVVGEDEV 598 Query: 594 --LTSIDCPTCGRKMGIR-TASTGV-FLGCSGYALPPKERCKTTINLVPENEVL 643 L CP CG + ++ TG F+GCS + +C T ++ E++ Sbjct: 599 KPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWP-----KCDVTYPILQRGEII 647 >UniRef50_O28469 DNA topoisomerase 1 n=8 Tax=Euryarchaeota RepID=TOP1_ARCFU Length = 663 Score = 190 bits (483), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 177/610 (29%), Positives = 289/610 (47%), Gaps = 70/610 (11%) Query: 89 KEKVVSE-LKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDD--ARYSRVVFNEITKN 145 KE+ +S LK++A+KAD + +ATD DREGE I E++ + + RV ++ +T+ Sbjct: 83 KERTISSILKEIAKKADRVTVATDYDREGELIGVEALEIVKSVNPTVKVDRVRYSAVTEK 142 Query: 146 AIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG----LSAGRVQSVAV 201 IR AF+KP +++ + NA AR+ +D + G ++ L+ R LS GRVQ+ + Sbjct: 143 EIRSAFSKPVKVDFNLANAALARQKIDLIWGATLTRLISVHSGRMGKDFLSVGRVQTPTL 202 Query: 202 RLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLL 261 RL+V+RE EI+ F PE+++E+ A E H P R +KE+ + + + Sbjct: 203 RLIVDRELEIQNFKPEKYYEIFA-------EFEGFIAKH----PKRYGSKEEAEKLFAKI 251 Query: 262 -EKARYSVLER----EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY 316 E A+ R E++PT PF T+ + AS + K M +A+ LY GY Sbjct: 252 GETAKVEEFTRRRMEENRPT------PFNTTEFLREASKFMS--PHKAMNIAETLYMNGY 303 Query: 317 ITYMRTDSTNLSQDAVNMVR--GYISDNFGKK-YLPESPNQYASKENSQEA--HEAIRPS 371 I+Y RTD+T + +N++ +S F ++ + S ++ +E H I P+ Sbjct: 304 ISYPRTDNT-VYPPTINLIEIVSALSSVFPREAQIVLSQDKITPSRGRRETKDHPPIYPT 362 Query: 372 DVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRF 431 V E + D +Y+L+ R+F+A A +D + + + + A GR L Sbjct: 363 GVAKRGE----LSKDEWTIYELVVRRFLATLAPKAVWDVRRVVLDSNGVKFVANGRQLVE 418 Query: 432 DGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGI 491 GW + + E+ LP + KGD L +++ + TKPP R+S +SL+K +EK + Sbjct: 419 AGWRDIY--IYSKAEETELPLLKKGDVLRILKKRLEEKETKPPGRYSASSLIKMMEKLNL 476 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G ST II + R Y + F + V + L+E + D TA++EN +D Sbjct: 477 GTKSTRHEIIQKLVSRRY--IHGNPFRPSETAFSVINVLKETAETITLPDMTAKLENEMD 534 Query: 552 QVANHEAEWKAVLDHFFSDFTQQL-----DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKM 606 +A + V+D Q L K KD E G++ +++V CP CG ++ Sbjct: 535 LIAEGKKREPEVVDESREMLLQILRAIDYRKLSKDLRE-GVKKDKIVG---KCPECGGEL 590 Query: 607 GIRTASTGV-FLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRR---- 661 +R + G F+GCS Y C T+ L P+N L + + E K R Sbjct: 591 VVRQSKAGKRFIGCSNYP-----DCTFTLPL-PQNGTLYITAKQCKEHEIKEVKIRTKKG 644 Query: 662 -----CPKCG 666 CP C Sbjct: 645 YWNLGCPYCN 654 >UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AUL7_RUBXD Length = 702 Score = 189 bits (481), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 164/598 (27%), Positives = 278/598 (46%), Gaps = 48/598 (8%) Query: 69 NRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH-LREVI 127 N VDP +A ++ V + ++ LA+KAD + +ATD DREGE I L Sbjct: 64 NWQKVDPRELIDARILKSVSEKGVAAAVRSLAKKADRVIIATDFDREGELIGVEALSLAF 123 Query: 128 GGDDA---RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 + A R F+ +TK + +AF E++ + +A +AR+ +D + G ++ + Sbjct: 124 EANPALMDHVERARFSALTKGEVTRAFENLVEVSRELADAGEARQDIDLIWGATLTRWVS 183 Query: 185 KKIAR----GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 + + R LS GRVQS + L+ ERE E +AFVPE +WEV+A G +A Sbjct: 184 RAVKRYGSAFLSVGRVQSPTLVLIAERELERRAFVPEPYWEVEARLQNGGGPFVARHA-- 241 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG-APFITSTLQQAASTRLGF 299 R KE+ +A +L + +V+ + ++P APF T+ AA+ +G Sbjct: 242 ------RGRFKEEAEARRALENLSETAVVTEVRQREATRPAPAPFNTTAFLTAAAN-IGV 294 Query: 300 GVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-VNMVRGYISD-----NFGKKYLPESPN 353 + +A+ LY GYI+Y RTD+T + + V G++++ ++ + L Sbjct: 295 SPSRAARIAEDLYTEGYISYPRTDNTVYPESLDLREVLGFLAEVEGVGDYAGRLLGAGRL 354 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 H I P+ AE + D K+YQL+ R+F+A PAK TTL Sbjct: 355 TPTRGRRQTTDHPPIYPTGRASRAE----LREDQWKIYQLVVRRFLATLSGPAKTLRTTL 410 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKP 473 +G L A G ++ +GW V R+ DE+ LP +++GD + + E T+P Sbjct: 411 RFESGGEPLVAGGTVVTEEGWLAVYHYGRRRDEE--LPRLSEGDEVRVAEAELLAKETQP 468 Query: 474 PARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEEN 533 P R+ + L++ +E G+G +T II + DRGY+ + + G V L++ Sbjct: 469 PGRYGQGRLIRLMEDLGLGTKATRPGIIQNLYDRGYIHGDP--IVPTETGMAVAKALKDF 526 Query: 534 FRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE------GGM 587 E+ +++ TA++E S+D ++ +V++ + D E E+ G+ Sbjct: 527 ASEIASHEMTARLEKSMDAISEGRVSKDSVVEESRELLRRVYDHLESSEEKFADIVWNGI 586 Query: 588 RPNQMVLTSIDCPTCG--RKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVL 643 R ++ T CP CG + + F GC GY C+TT L + +++ Sbjct: 587 RGDE---TLGPCPNCGRNLVVRRNRRNRKRFAGCEGYP-----ECRTTFPLPQKGDII 636 >UniRef50_B1L3G6 DNA topoisomerase I n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3G6_KORCO Length = 710 Score = 189 bits (480), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 184/691 (26%), Positives = 302/691 (43%), Gaps = 104/691 (15%) Query: 86 LPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKN 145 + GK + + L++L + ++ I +ATDLD EG +IA + + + + R+ F+ +TK Sbjct: 79 IKGKREYLKILEKLGKLSNRIIVATDLDSEGSSIALEIIKALNWEGKEILRMEFSSLTKE 138 Query: 146 AIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW-----KKIARGLSAGRVQSVA 200 IR +F + R A RR +D G VS L K R LS+GRVQ Sbjct: 139 EIRSSFRDLKPFDYPRAYAGWVRRVIDLEWGANVSRGLTLSTRRKGWVRVLSSGRVQGPT 198 Query: 201 VRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSL 260 + ++V+REREI+ FVP++++ V G +L L ++ + + +V Sbjct: 199 LSMIVKREREIREFVPKKYYTVIVKVD--KGFSLELAPPKGEERIWDQDYARRAAESVKD 256 Query: 261 LEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK----KTMMMAQRLYEAGY 316 AR ER+ P PF ++LQ S G + +T +AQ+LYEAG Sbjct: 257 TLIARVKSDERKLSPP-----PPFDGTSLQVEVSAITGLTPRQIADRTSGIAQKLYEAGL 311 Query: 317 ITYMRTDSTNL-----SQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPS 371 I+Y+ T+S +D V+MV+ S Y P + +EA + Sbjct: 312 ISYIGTESQKYPKSWKKKDFVDMVKLIAS------YSPLKEEAEFVLGDMREAAVEGKKD 365 Query: 372 D-----VNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARG 426 D ++V+ + +E +++Y++I R+ +A A + F +A G Sbjct: 366 DPAHPTIHVVGVPEERLEGKYREVYEIIARRNLATLAQDALIKRIRVESNVDGFIFRASG 425 Query: 427 RILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL 486 + +GW +V P R + P V + L +VE+ + T+PP R+S SL+KE+ Sbjct: 426 LSVLREGWLRVYPYARMEE----FPEVEDSEELRVVEVKIEEKETQPPKRYSHISLIKEM 481 Query: 487 EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546 E+ G+G +T II ++ RGY +E F ++GE + + LE L N + TA++ Sbjct: 482 ERLGLGTKNTRVQIIDILKSRGY--LEEGSFKPTRLGEAIVEVLESFVPALTNPELTAKL 539 Query: 547 ENSLDQVANHEA-----------EWKAVLDHFFSD---FTQQLDKAEKDPEEGGMRPNQM 592 E ++++ + E A++D F + +++L + ++ G + Sbjct: 540 ERGMNEIELGKLDPSNFLKESLDELSAIMDEFKRNELKISERLYEGLREYRSGSLG---- 595 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 CP CG + +R +S G F+ CS Y E+C NL +NE EG+ E Sbjct: 596 -----KCPECGGDLNMRKSSYGYFIVCSNYP----EKCDVKFNLF-KNE---RFEGKFCE 642 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPK----RKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 CG + S I K R C N CD + Sbjct: 643 ------------CGLPLVSGRIKTKSNRGRGYTRCIAN--CDRTPL-------------- 674 Query: 709 VECEKCGSEMHLKMGRFGKYMACTNEECKNT 739 C KCG M K G+FG Y+ C N C +T Sbjct: 675 -RCAKCGGPMVAKQGKFGVYLKCEN--CGST 702 >UniRef50_C0QU27 Reverse gyrase n=1 Tax=Persephonella marina EX-H1 RepID=C0QU27_PERMH Length = 1164 Score = 188 bits (478), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 156/585 (26%), Positives = 280/585 (47%), Gaps = 59/585 (10%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 +VIVESP KA+TI + G R L + D T A K + Sbjct: 610 TVVIVESPNKARTIANFFGKPLR--------RKLKGIDAYEIAIGDKFLTIIASKGHIFD 661 Query: 64 RGALVNRMGVDPWHNWEAHYE-VLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 GV ++ +E + G++ ++ +++L + +++ATD D EGE I++ Sbjct: 662 LNKEEEYFGVRKNSHFIPVFEPIDEGRKHIIEGIRELDLEVQEVFIATDPDTEGEKISYD 721 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L + + R F+E+TK A +A +++ + V AQ RR DR +G+ +S Sbjct: 722 LYLLSKPYNFNVKRAEFHEVTKKAFLEAVENYRDIDKNLVKAQLLRRISDRWIGFTISQY 781 Query: 183 LWKKIARG-LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 + +K+ R LSAGRVQ+ + ++ER T + + +A+ Sbjct: 782 VQEKLHRHYLSAGRVQTPVLEWIIER-------------------TDQAKQKIAVVRVFI 822 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 ++ P + E A + ++ ++ ++K PF T T+ A++ LGF Sbjct: 823 DNIPVE-FSFEDRNRAKWFYQNIQFVIVSVKEKKEEKLFVRPFSTDTMLTASARELGFSP 881 Query: 302 KKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENS 361 ++TM +AQ L+EAG ITY RTDS +S V + + YI +NFG +Y+ Y++ E Sbjct: 882 QETMSLAQDLFEAGLITYHRTDSIRVSDAGVFVAKEYIQENFGSEYI--KIRTYSTYEG- 938 Query: 362 QEAHEAIRPS---DVN-----VMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 AHE IRP+ D + V +L+ + +LY LI+RQF+A QM A + Sbjct: 939 --AHECIRPTRAVDADELRSMVYTMNLQGITRKHIRLYDLIFRQFIASQMREAVVEKVVY 996 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKP 473 +V A D ++ T ++ + + D ILP V++ + KP Sbjct: 997 SVRAFDEEVE-----------TDLITDIIQHGYDLILPIRTDKLPEGKVDIKKKSYHLKP 1045 Query: 474 P-ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF-YAEKMGEIVTDRLE 531 + ++ ++KE++++GIGRPSTYA + + DR Y+ +E R + + K+G V + ++ Sbjct: 1046 KVSYYTFGEIIKEMKEKGIGRPSTYAITVQKLLDRHYI-IERRGYLFPTKLGRQVMELIK 1104 Query: 532 --ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQ 574 E+ +N FT ++E+ +D++ +A+++ L+ F + ++ Sbjct: 1105 RREDIYRFVNESFTKELESLMDRIEQGKADYEKELEKLFKELEEK 1149 >UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina EX-H1 RepID=C0QUY8_PERMH Length = 834 Score = 185 bits (469), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 146/509 (28%), Positives = 262/509 (51%), Gaps = 28/509 (5%) Query: 82 HYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG--GDDARYSRVVF 139 Y+V GK K + +K L +KAD I++ TD REGE IA + G G D Y Sbjct: 69 EYKVSKGKNKQFNIVKSLVKKADEIFVNTDAGREGELIARLILLYSGWNGWDKTYRFWTS 128 Query: 140 NEITKNAIRQAFN--KPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG--LSAGR 195 +TKN I + KP + + AR+ D +VG ++ L + G S GR Sbjct: 129 EALTKNVILRELKARKPAKNWDSLFYSGLARQQSDWLVGINLTRALTVIVGDGSVWSIGR 188 Query: 196 VQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQ 255 VQ+ ++L+VER+ EIK F P+ +W+++A S + ++ ++ D F NK + Sbjct: 189 VQTPVLKLIVERDLEIKNFKPKPYWQLEAVFEKDS-QKFKAKLLNEKDTIFEDKNK-IWE 246 Query: 256 AAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG 315 +L +K + V E E K F +TLQ A+ R GF +KT+M+AQ LYEA Sbjct: 247 IFKALKDKDKAVVKEIEKKQHKKYAPPLFSITTLQMTANKRFGFTAQKTLMLAQDLYEAK 306 Query: 316 YITYMRTDSTNLSQD--AVNMVRGYISDNFGKKYLPESPNQYASK---ENSQEAHEAIRP 370 YI+Y RT++ +L ++ ++V+ I G++ L E+ ++ + + H AI P Sbjct: 307 YISYPRTEAQHLDENPSTKDLVKN-ILKKLGEEQLIENVDKVGKRVFDSSKLTDHYAIIP 365 Query: 371 SDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRIL 429 ++ ++ K+ + D K+Y+LI +F+A M P +Y++T + ++ A G++ Sbjct: 366 MNLLTEEKAKKEGLNQDHLKIYELIKNRFLAVFMPPYEYETTKAILDIDGYQFTASGKVE 425 Query: 430 RFDGWTKVMPALRKGDEDRI---LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL 486 GW + R+ ++D+I LP + KGD + + + TKPPA ++E++L+ ++ Sbjct: 426 LSLGWKAID---REDEDDKIEAPLPQLEKGDMVHKISQRVIEDKTKPPAHYTESTLLNKM 482 Query: 487 EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546 ++ +G +T A II T++DR Y++ + + A + G + +++++ +E + T++ Sbjct: 483 KQLELGTGATRAGIIQTLKDRFYIKNKGKSLIATEKGFALIEKIKD--KEFASPKMTSKW 540 Query: 547 ENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 E L+Q+ + K + DF Q+ Sbjct: 541 EQQLEQIYTQKLGKKG-----YEDFLNQI 564 >UniRef50_A8A8D9 DNA topoisomerase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A8D9_IGNH4 Length = 657 Score = 185 bits (469), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 144/494 (29%), Positives = 247/494 (50%), Gaps = 40/494 (8%) Query: 77 HNWEAHYEVLPG---KEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDAR 133 + W YE+ G +K ++ + L+ + A D D EG I + + E G D R Sbjct: 68 YEWRPLYEIEKGASHTKKYIALISSLSPGSSLYVNACDYDVEGSVIGYIIIERFG-DPRR 126 Query: 134 YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWK--KIARG- 190 R+VF+ +T + IR+A+N L+ + +NA AR +D + G VS L ++A G Sbjct: 127 SKRMVFHALTPDEIRRAWNSLRPLDWEMINAGLARHELDWIWGINVSRALMHAYRVATGK 186 Query: 191 ---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFR 247 LSAGRVQS ++ VVERE ++ FVPE ++ V S + ++L+ T + + Sbjct: 187 SKSLSAGRVQSPTLKEVVERELAVQCFVPEPYFSVSLS-----AKGVSLEPTLKFE---- 237 Query: 248 PVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMM 307 K++ +S V+ +++ + P PF LQ A+ GF KT + Sbjct: 238 --TKDEADHFISNCLGKVVDVIVNDERLS---PPHPFNLPDLQMEAARLYGFSPSKTQSI 292 Query: 308 AQRLYEAGYITYMRTDSTNLSQDA--VNMVRGYIS----DNFGKKYLPESPNQYASKENS 361 A+ LY YI+Y RT+S +D N+++G S K E+ +++ Sbjct: 293 AEELYLDAYISYPRTNSQKYPKDLDYANILKGIASVPQYRPLTKALFKETRGRFSPNNGP 352 Query: 362 QE--AHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD 419 ++ AH AI P+ + K++ D K+Y LI R+F+A + + Y+ T + + Sbjct: 353 KDDPAHPAIYPT-----GKPPKNLSPDHMKVYDLIVRRFMATLASESVYEVTKVVIEVNG 407 Query: 420 FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSE 479 KA GR +++ GWT P +++ LP+ KG++L V+ T +TKPP R+++ Sbjct: 408 QTFKAVGRRVKWKGWTLYYPF--SAPQEKSLPSFTKGESLQ-VKCTRRLQYTKPPERYTK 464 Query: 480 ASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMN 539 A +VK +E+ GIG +T A I+ T+ RGY++ + YA +G V L + F E+++ Sbjct: 465 AKIVKWMERVGIGTEATRARIVETLFKRGYLKNVGSKVYATDLGIGVALVLSKFFPEIVS 524 Query: 540 YDFTAQMENSLDQV 553 + T + E + ++ Sbjct: 525 VELTRRFEEDMKKI 538 >UniRef50_A3DNK7 Reverse gyrase n=1 Tax=Staphylothermus marinus F1 RepID=A3DNK7_STAMF Length = 1313 Score = 184 bits (468), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 179/669 (26%), Positives = 283/669 (42%), Gaps = 151/669 (22%) Query: 4 ALVIVESPAKAKTINKYLG------------------SDYV--VKSSVGHIRDLPTSGSA 43 AL+IVESP KA+TI + G DYV + +S+GH+ DL Sbjct: 674 ALLIVESPNKARTIANFFGKPSIRILENGMPVYDVTTGDYVLSIIASIGHVYDLVVDDGL 733 Query: 44 AKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPG--------KEKVVSE 95 K +R N+ G + + A P K +V Sbjct: 734 YNYGVRLVGDKFIPVYTDIKR---CNKCG----YQFTAETNTCPKCGSRDISRKLDIVET 786 Query: 96 LKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG 155 L++LA + D +++ TD D EGE I W ++ ++ RV F+EIT+ AI A P Sbjct: 787 LRELANEVDVVFIGTDPDTEGEKIGWDIKVLLEPYAREIKRVEFHEITRKAILNAIRNPR 846 Query: 156 ELNIDRVNAQQARRFMDRVVGYMVS-----------------PLLWKKIARG-------- 190 + ++ V AQ RR DR +G+ +S PLL K + G Sbjct: 847 DFDMKLVEAQIVRRVEDRWLGFALSKKVQKYFWPIYCFKVLHPLLNKYVREGKRITDKMP 906 Query: 191 --------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LSAGRVQ+ + ++ R +E + L N Sbjct: 907 FCCIENRNLSAGRVQTPVLGYIIRRFKE----------------HNDESKFRYLLTIKIN 950 Query: 243 DKPFRPVNKEQTQAAVSL-----LEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 D R + + L R V E + K P PF T TL + AS RL Sbjct: 951 DSRLRVDIDRSVLEIIGITSHRNLIGYRVEVREEDRKEEIINPPPPFTTDTLLEEASIRL 1010 Query: 298 GFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKK----YLPESPN 353 G +TM +AQ L+E G ITY RTDST +S +N+ R Y+ + G+K + P + Sbjct: 1011 GLSTTRTMEIAQELFELGLITYHRTDSTRISDAGINVARQYLEEKLGEKAKEVFKPRTWG 1070 Query: 354 QYASKENSQEAHEAIRPS---DVNVMAESLKD--------MEADAQKLYQLIWRQFVACQ 402 AHEAIRP+ D + +AE +++ + +Y+LI+ +F+A Q Sbjct: 1071 VGG-------AHEAIRPTRPIDADRLAELIREGALILARPLTRLHYMVYKLIFNRFIASQ 1123 Query: 403 MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKG--DALT 460 M PAK L + R +G+ K + +R++ + KG + Sbjct: 1124 MIPAKIVKQVLKI--------------RMNGYEKKV--------ERVIGIIEKGFLEFYQ 1161 Query: 461 LV----ELTPAQH------FTKPP-ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 V E+ P + KPP AR+ + ++K ++ GIGRPSTYA II T+ DR Y Sbjct: 1162 TVNVEEEVKPGTYPVVDVEVLKPPLARYHD--VIKWMKTNGIGRPSTYAKIIQTLIDRKY 1219 Query: 510 VRVENR--RFYAEKMGEIVTDR-LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 V V R K G +V + L++ ++++++ + T ++E + +V +++ VL Sbjct: 1220 VNVSKRVKALIPTKRGTMVYEEFLDKYYKDVVSVEVTRELEKKMKEVEEGIRDYQEVLHE 1279 Query: 567 FFSDFTQQL 575 F++ ++ Sbjct: 1280 IFNELKTKI 1288 >UniRef50_B1L5U0 Reverse gyrase n=2 Tax=Archaea RepID=B1L5U0_KORCO Length = 1085 Score = 183 bits (465), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 168/607 (27%), Positives = 269/607 (44%), Gaps = 83/607 (13%) Query: 4 ALVIVESPAKAKTINKYLG-----------------SDYV--VKSSVGHIRDLPTS-GSA 43 AL IVESP+KA+TI + G DYV + +S GHI DL T+ G Sbjct: 526 ALFIVESPSKARTIASFFGRPSRRFLDGLMAYEVTTGDYVLTIVASGGHIVDLTTTMGYH 585 Query: 44 AKKSADSTSTKTAKKPKK-DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK 102 D T K+ + G M P L VV L++L+ + Sbjct: 586 GVLIEDGTYVPAYTSIKRCNSCGHQFTDMDRCP----RCGSTDLRDSRSVVESLRRLSFE 641 Query: 103 ADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRV 162 A + + TD D EGE IAW + ++I R F+E+TK AI +A +N V Sbjct: 642 ASRVIIGTDPDTEGEKIAWDIYQLIMDSSGEIYRAEFHEVTKRAIIEALKSLRGINERMV 701 Query: 163 NAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 AQ RR DR +G+ +S + K+ R LSAGR Q+ + V++R RE + Sbjct: 702 EAQIVRRVEDRWIGFELSAEVQKRFGKRNLSAGRAQTPVLGWVIDRYRE---------HQ 752 Query: 222 VDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 + G+ L L+V + V +E ++ + E + + KP Sbjct: 753 NKKVVSIIKGDGLLLRVDGR-------VGEEGA---------SKIWIRELKIEEEVVKPP 796 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 PF T + A+ L TM +AQ L+E G ITY RTDS +S + S Sbjct: 797 PPFTTDAMIGEANRVLRMSANMTMQLAQFLFETGLITYHRTDSPRVSDAGFRVA----SL 852 Query: 342 NFGKKYLPESPNQYASKENSQEAHEAIRPSD-------VNVMAESLKDMEA---DAQKLY 391 G+ ++P K AHE IRP+ ++ + E + +E D +LY Sbjct: 853 VLGEDFVPR-------KWGEGGAHECIRPTKPLSAKELIDYVKEGIIAVEGLSKDHIRLY 905 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILP 451 LI+R+F+A Q +V G+ + + GW P L + P Sbjct: 906 DLIFRRFIASQSRDGTLVKQVASVRVGESEFEVTRLVEARGGWIDWYPFLHITE-----P 960 Query: 452 AVNKGDALTLVELTPAQHFTKPPA-RFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 + +G ++E H T P +++++LV +++RGIGRPSTYA+I+ I RGYV Sbjct: 961 RLKEGMVDVIIE-----HQTVPSVPLYTQSNLVALMKERGIGRPSTYATIVEKILQRGYV 1015 Query: 511 RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 N++ K+G V + L + F +L++ + T +E +D + A+++ ++D + + Sbjct: 1016 IERNQKLIPTKLGIEVYNFLRDRFPDLISEERTRTLERKMDSIEEGAADYQELIDELYKE 1075 Query: 571 FTQQLDK 577 +++ K Sbjct: 1076 IREKIGK 1082 >UniRef50_B7IEV8 Reverse gyrase n=1 Tax=Thermosipho africanus TCF52B RepID=B7IEV8_THEAB Length = 1031 Score = 182 bits (463), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 169/604 (27%), Positives = 276/604 (45%), Gaps = 95/604 (15%) Query: 5 LVIVESPAKAKTINKYLGSDYV-------------------VKSSVGHIRDLPT-SGSAA 44 L+IVESP KA+T+ K+ G + + ++ GH DL T G Sbjct: 479 LIIVESPTKAETLAKFFGISSIRSLNGLISFESITKEGLITITATKGHTYDLITREGYHG 538 Query: 45 KKSADSTST---KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAE 101 + +++T T KK K D V+ P N + + K V+ L++L+ Sbjct: 539 VEFSNNTFIPIYNTIKKCK-DCGYQFVDNYDKCPKCNSKN----IDDKLSVLKALRELSL 593 Query: 102 KADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDR 161 + D I +A+D D EGE IA+ + + I ++ R+ +EIT+NA + ++ E+ + Sbjct: 594 EVDEILIASDPDVEGEKIAYDILQYIYPVNSNIKRIELHEITRNAFLKGIDEKREIKENL 653 Query: 162 VNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 V +Q RR DR +G+ +S L R LSAGRVQS + +++RE+E K + + Sbjct: 654 VKSQIIRRIEDRWIGFELSQKLQTNFKRTLSAGRVQSTVLGWIIQREKEYKNSIKK---- 709 Query: 222 VDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 S T +G + + H+N A +E ED T P Sbjct: 710 -FTSFTFENGLKVEFEGIHEN--------------ATLKIENIY------ED---TIAPP 745 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 APF TST+ S + V + M + Q L+E G+ITY RTDST +S+ + Y Sbjct: 746 APFNTSTILSEISKKYKLSVNEIMSILQNLFENGFITYHRTDSTRISKTGQAVAEKYFK- 804 Query: 342 NFGKKYLPESPNQYASKENSQE-AHEAIRPSDVNVMAESLKDM------EADAQKL--YQ 392 L P+ Y K E AHE IRP + E LKDM D + L Y+ Sbjct: 805 ------LINKPHLYKPKSYGNEGAHEGIRPVK-PISPEELKDMIKEKIINLDKKHLLIYK 857 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRF--DGWTKVMP--ALRKGDEDR 448 I+ +F+A Q K L + + + K+ I DGW MP ++ DE++ Sbjct: 858 EIFNRFLASQSKEIKVKKARLNIITENSK-KSEEIITEILEDGWNIFMPIKVIQIMDENK 916 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPA-RFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 + T + + K F++A++++E++ + IGRPSTYA IIS + +R Sbjct: 917 V---------------TDRKVYNKHTVPLFTQATIIEEMKSKNIGRPSTYAKIISVLFER 961 Query: 508 GYVRVEN-RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 Y+ + +R K+G+IV + L + + +N + T +E +D+V E++ L Sbjct: 962 KYIFEDKYKRIIPTKLGKIVYNFLNSKYNKFINEETTRTLEKIMDEVEKGIKEFQQTLHE 1021 Query: 567 FFSD 570 +++ Sbjct: 1022 IYNE 1025 >UniRef50_Q8GJE2 TopA n=2 Tax=Campylobacter RepID=Q8GJE2_CAMJJ Length = 655 Score = 182 bits (463), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 162/585 (27%), Positives = 261/585 (44%), Gaps = 81/585 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M ++I+ESP K + I K G+ V ++ GH + L Sbjct: 1 MENTIIIIESPNKREKIEKITGAK--VYATKGHFKSL----------------------- 35 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++ + + N+E ++ + K K + +ATD DREG IA Sbjct: 36 --------SKNFLKEYENYEPIFDFSSDETKKRMNAIFADCKNKDVIIATDPDREGYGIA 87 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL---NIDRVNAQQARRFMDRVVGY 177 + EVI R F+EIT++ I + E N++ A +AR D++VG+ Sbjct: 88 YLFYEVIKNIAKSIKRAEFHEITESGINKGLKNAVEFSKSNLNDFEAFKARIVGDKLVGF 147 Query: 178 MVSPLLWKKIA-RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 ++SP K+ + +S GRVQ+ A+ L+VERE+ I+ F+ ++ + E + Sbjct: 148 IMSPKYINKMNDKNISVGRVQTPALSLIVEREKAIQDFLNDDNNKKLDYKIKAKLEKDGI 207 Query: 237 QVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 V + N+ P NKE+ + L + E K + KP PF TS Q+ A+ Sbjct: 208 -VFYANNPNLYP-NKEEALEKIESLRSKNAKLYTIETKKSEIKPAQPFRTSQFQEKANKI 265 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 GF K+M +AQ+L+E G ITY RTDS LS + +N V + F +K + A Sbjct: 266 FGFAPDKSMALAQKLFEKGLITYHRTDSNALSVEFLNEVEAF----FKEKQWYQKREYKA 321 Query: 357 SKENSQEAHEAIRPSDVNVMAESLK-----DMEADAQKLYQLIWRQFVACQMTPAKYDST 411 ++ EAHEAIR S ++ + K ++ D + Y LI+ + Q A + T Sbjct: 322 GDQSQAEAHEAIRISHLHSFEDIEKIAREENLSDDEKNTYTLIYLNSIQSQAKNAINEIT 381 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKG-----------------DEDRILPAVN 454 + G IL F T + + KG D + + Sbjct: 382 SYDFNIG---------ILSFK--TNISKCIDKGFKGAFDFKEEDEKDEKDDTQELELNIK 430 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-- 512 +G+ + +++ + + P R+ E++ + LEK GIGRPSTYAS + T+ DR YV + Sbjct: 431 EGEEIQVLDFELIEVKKQAPRRYKESNFISLLEKEGIGRPSTYASFLKTLLDREYVELAT 490 Query: 513 --ENRRFYAEKMGEIVTDRLEENFRE-LMNYDFTAQMENSLDQVA 554 +N+ A K G + D L EN E + +FT QME LD ++ Sbjct: 491 KGKNKEIVATKKGISLIDFLNENDDEWITKSEFTKQMEEILDTIS 535 >UniRef50_A7I6L6 DNA topoisomerase n=5 Tax=Methanomicrobiales RepID=A7I6L6_METB6 Length = 942 Score = 182 bits (461), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 154/556 (27%), Positives = 266/556 (47%), Gaps = 39/556 (7%) Query: 86 LPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG--DDARYSRVVFNEIT 143 +P ++++VS +++LA AD + +ATD D EGE I E++ + + R F+ IT Sbjct: 80 VPTEKRIVSLVQKLARHADRVTIATDFDTEGELIGKEAYELVRAVNKNVKIDRARFSAIT 139 Query: 144 KNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG----LSAGRVQSV 199 I AF +L+ A +AR+ +D + G ++ + RG LS GRVQS Sbjct: 140 AQEIGSAFANTTDLDFALAAAGEARQSIDLMWGASLTRFISLAAKRGGNNILSVGRVQSP 199 Query: 200 AVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN----DKPFRPVNKEQTQ 255 + ++V+RE+EI+ FVPE++W++ T +GE + + H N D+ + +++T+ Sbjct: 200 TLSMIVDREKEIEKFVPEKYWQL-GLLTEKAGEQI--EARHTNGRFKDQKAAELARDRTK 256 Query: 256 AAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG 315 + + E RE P +PF T+T AA+ RLGF M +A+ LY G Sbjct: 257 EPLVVTEV-------REGTKQDRSP-SPFDTTTYIVAAA-RLGFSAANAMRIAEELYMNG 307 Query: 316 YITYMRTDSTNLSQDA-VNMVRGYISDN-FGKK---YLPESPNQYASKENSQEAHEAIRP 370 YI+Y RTD+T +N V I ++ F K + + + S H I P Sbjct: 308 YISYPRTDNTVYPASLDLNGVLATIRNSPFTKDVDWIISHRRAEPTRGKKSSTDHPPIYP 367 Query: 371 SDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILR 430 + V E + D DA ++Y+L+ R+F+A A + + + AG G +L Sbjct: 368 TGV-ATREGIGD---DAFRIYELVLRRFLATLAPDALWKTLKVNFEAGGETYTVTGGLLL 423 Query: 431 FDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRG 490 GW V P ++ ILPA G+ L + ++ + T PPAR++++ L++ +E+ G Sbjct: 424 EPGWHAVYPFSEA--KETILPAFVTGEKLPIRKVNLEEKETLPPARYTQSKLIQRMEELG 481 Query: 491 IGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSL 550 +G ST +I+ + R Y +E +G +VT+ LE+N + + T +E+ + Sbjct: 482 LGTKSTRHEVIARLVSRKY--IEGNPLRPTLVGRVVTEALEQNADTITKPEMTQTIESHM 539 Query: 551 DQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID---CPTCGRKMG 607 Q+ + V+ S + D+ E + + G ++ CP CG + Sbjct: 540 QQIKESKRTRDDVIAESRSMLHKAFDQLEANEQVIGNDIRDRTAEELNLGRCPACGGTLA 599 Query: 608 IRTA-STGVFLGCSGY 622 I+ + F+GCS Y Sbjct: 600 IKHMRGSTQFIGCSRY 615 >UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6YTB3_THEON Length = 717 Score = 180 bits (456), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 171/620 (27%), Positives = 277/620 (44%), Gaps = 64/620 (10%) Query: 93 VSELKQLAEKADHIYLATDLDREGEAIAW-HLREVIGGDDARYSRVVFNEITKNAIRQA- 150 + L LA++AD +A D D EGE I + L+ G D ++ R+ F+ +TK + +A Sbjct: 90 IKALATLAKRADEFVVACDYDTEGEVIGYTALKYACGVDPSKAKRMKFSALTKKDLLKAW 149 Query: 151 FNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLV 204 +N +N +A AR +D G +S L I R LS GRVQ ++ + Sbjct: 150 YNLESTINFGMADAGIARHVLDWYWGVNLSRALTSAIKRASGKWMVLSTGRVQGPTLKFL 209 Query: 205 VEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKA 264 V+RE+EI+ F P +W + E Q T +K R +++ + + V +K Sbjct: 210 VDREKEIQNFKPTPYWVIKMVL-----EKNGQQYTAVYEKE-RILDENEAKRIVEEAKKG 263 Query: 265 RYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDS 324 V + + K P PF TLQ+ A + G+ KKT+ +AQ+LYE G +Y RT S Sbjct: 264 PAFVEKVDVKQQNRHPPVPFDLGTLQREAYSAFGYSPKKTLELAQKLYERGLTSYPRTSS 323 Query: 325 TNLSQDAVNMVRGYISDNFGKKYLPES---PNQYASKE--------NSQEAHEAIRPSDV 373 L + N+ I N K LPE ++ KE AH AI P+ Sbjct: 324 QKLPK---NLNFRSILQNLAK--LPEYKPFAHELLGKERLKPVEGKKDDPAHPAIYPTGE 378 Query: 374 NVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDG 433 L EA+ LY LI R+F+A M PA + + + + R G +G Sbjct: 379 LPKPGELTKDEAN---LYDLIVRRFLALFMEPAVREIMKVIINSNGHRFILSGARTIKEG 435 Query: 434 WTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGR 493 W KV K DE ILPA +G+ + ++++ + TKPPAR+S A+++K +E GIG Sbjct: 436 WLKVYGKYVKFDEA-ILPAFKEGEPVKVLQIKREKKKTKPPARYSPAAVIKRMEDLGIGT 494 Query: 494 PSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQV 553 +T A I+ T+ RGY+ ++ +G V + LE N ++++ + T E ++++ Sbjct: 495 KATRAQILETLYSRGYIE-GKKKIKVTPLGMRVVEALERNVPDIVSVELTRAFEEKMEEI 553 Query: 554 ANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAST 613 +A+ D + +QL K + +E + ++++ T T Sbjct: 554 MAGKAD----KDRVIEESKEQLIKILQQFKEKELDIGKVLM--------------ETTGT 595 Query: 614 GVFLGCSGYALPPKERCKT--TINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAM-D 670 GV KE K T+ + E E +V + + +CPKCG + Sbjct: 596 GVTTS--------KENAKRAGTVKELSETEEKDVKKTIEKGEKTPLVVGKCPKCGGDLVV 647 Query: 671 SYLIDPKRKLHVCGNNPTCD 690 Y ++ C N P C+ Sbjct: 648 RYNRKTGKRFVGCSNWPKCN 667 >UniRef50_B8D4X1 Reverse gyrase n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D4X1_DESK1 Length = 1334 Score = 179 bits (454), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 184/673 (27%), Positives = 290/673 (43%), Gaps = 149/673 (22%) Query: 4 ALVIVESPAKAKTINKYLG------------------SDYV--VKSSVGHIRDLPTSGSA 43 AL+IVESP KAKTI + G +YV + +S GH+ DL T Sbjct: 678 ALMIVESPNKAKTIANFFGKPSIRVVKDVLQAYEVTVGNYVLSIVASAGHVYDLITDNPG 737 Query: 44 AKKSADSTSTKTAKK--------PKKDERGALVNRMGVD-----PWHNWEAHYEVLPGKE 90 + + KK G +D P + K Sbjct: 738 ESMGENLYGVLKIENRFIPVYTDIKKCSNGHQFTDEVIDNTNECPKCRINGKVSHVTRKL 797 Query: 91 KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQA 150 +V L++LAE+ D + + TD D EGE IAW LR ++ + R+ F+E+T+ AI A Sbjct: 798 DIVKALRELAEEVDVVLIGTDPDAEGEKIAWDLRVLLEPYASDIKRIEFHEVTRKAILNA 857 Query: 151 FNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL----WKKIA------------------ 188 P + ++ V +Q RR DR +G+ +S + W K Sbjct: 858 LKNPRDFDLKLVESQIVRRIDDRWLGFSLSEKVQKYAWLKYCSEYLKNKTVKEEKDDSEL 917 Query: 189 ---------RGLSAGRVQSVAVRLVVERERE----------IKAFVPE--EFWEVDASTT 227 R LSAGRVQ+ + +V+ E IK +V + +F EV T Sbjct: 918 HEFDCCTQNRNLSAGRVQTPVLEYIVKETEERRKPERWSYRIKIYVEDVGDFVEV----T 973 Query: 228 TPSGEALALQVTHQ-NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFIT 286 P +A L V N K PV ++ ED + P PF T Sbjct: 974 IPYIDAEELGVIKSLNKKKLLPVE----------------IIVIGEDVEEVN-PLPPFTT 1016 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 L + AS L + M +AQ L+E G ITY RTDST +S +++ R Y+ + +G+K Sbjct: 1017 DALLEEASRSLRLSAVRAMEIAQNLFETGLITYHRTDSTRVSDTGISIARQYLEEKYGEK 1076 Query: 347 YLPESPNQYASKE---NSQEAHEAIRPS---DVNVMAESLKD--------MEADAQKLYQ 392 Q+ K AHEAIRP+ D + + E +K+ D +LY Sbjct: 1077 ------AQFYFKARMWGEGGAHEAIRPTRPIDADRLLELIKEGVLTLSVKFTKDHIRLYD 1130 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPA 452 LI+R+F+A QM PAK F++ + R + +T+ A+ KG L Sbjct: 1131 LIFRRFIASQMRPAKLRKLK-------FKVVIKNREYYSEVYTE---AVEKG----YLEV 1176 Query: 453 VNKGDALTLVELTPAQ------------HFTKPPA-RFSEASLVKELEKRGIGRPSTYAS 499 + + + L P++ KPP RF + +V+ +++ GIGRPSTYA Sbjct: 1177 YKNIELVQGIRLKPSEPGGRINGKIHEGEVIKPPMLRFHD--VVRWMKENGIGRPSTYAK 1234 Query: 500 IISTIQDRGYVRV--ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHE 557 II TI DR YV V E + + G V L++++ ++++ D T ++E+ +++++ E Sbjct: 1235 IIQTIIDRRYVIVSGETKALIPVERGRYVLKFLKDHYGDIVSVDTTRRLEDLMEKISRGE 1294 Query: 558 AEWKAVLDHFFSD 570 +++ VL+ + + Sbjct: 1295 RDYQEVLEEIYRE 1307 >UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms RepID=C6CZS8_PAESJ Length = 719 Score = 179 bits (453), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 203/736 (27%), Positives = 324/736 (44%), Gaps = 147/736 (19%) Query: 3 KALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ AK I + LG DYVV ++GH+ L A + D Sbjct: 2 KSLVLAEKPSVAKEIARVLGCSSKNKSYMEGPDYVVTWALGHLVTL-----AEPEDYD-- 54 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAH-YEVLPGKE--KVVSE-------LKQLAE 101 PK + W +LPGK KV+ E + QL + Sbjct: 55 -------PK---------------YKTWNLEDLPLLPGKMNLKVMRETSHQYKAVAQLCK 92 Query: 102 KAD--HIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGEL 157 + D + +ATD REGE +A + E++ + R+ + T AI+ F KPG+ Sbjct: 93 RPDIGELIIATDAGREGELVARWIMELVHWRKP-FKRLWISSQTDKAIKDGFKALKPGQQ 151 Query: 158 NIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPE 217 + + R D ++G V+ L K L+AGRVQ+ + +++RE+EI F + Sbjct: 152 YNNLYASAVCRAEADWLIGLNVTRALTVKYNAQLAAGRVQTPTLGALIDREKEINQFQSQ 211 Query: 218 EFWEVDASTTTPSGEALALQ-VTHQNDK-PFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 +W V S E A Q + QND R ++ + +A ++ L+ V DK Sbjct: 212 PYWTV-------SAELGAFQALWRQNDNHDGRVWDRSEAEAVIARLQGKSAKV----DKL 260 Query: 276 TTSKPGAP----FITSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTNLSQD 330 T++ P F + LQ+ A+ RLGF K T + Q+LYE +TY RTDS LS D Sbjct: 261 RTTQKSEPHPQAFDLTELQREANKRLGFSAKMTSNVLQKLYEQHKLVTYPRTDSRYLSSD 320 Query: 331 AVNMVRGYISDNFGKKYLPESPNQYASK---------ENSQEAHEAIRPSDVNVMAESLK 381 V ++G + Y P + + ++ H AI P+D V +L Sbjct: 321 IVPTLKGRLESVAVGPYAPLARKLLRGQLTVTKRFVDDSKVSDHHAIIPTDEYV---NLS 377 Query: 382 DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM--- 438 + D +KLY LI R+F+A P YD T++ + G +L A+G++ + GW ++ Sbjct: 378 ALSNDERKLYDLIVRRFIALFYPPYTYDETSVVLTVGQDKLYAKGKVQKDIGWKELYGGS 437 Query: 439 PALRKGDED---------------RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLV 483 A DED ++LP + +G A+ + + + T PPAR++EASL+ Sbjct: 438 DARFTADEDDEEENGRGEDKSTPEQLLPELVQGQAVQVKQSRLKELRTLPPARYTEASLL 497 Query: 484 KELEKRGIGRPSTYASIISTIQDRGYV-RVENRRFYAEK---MGEIVTDRLEENFRELMN 539 ++EK G+G P+T A II + + R +NR K + E+V D EL + Sbjct: 498 SKMEKHGLGTPATRADIIEKLLSTDTIERTQNRLVPTSKGKQLIELVVD-------ELRS 550 Query: 540 YDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK---AEKDPEEGGMRPNQMVLTS 596 + TA+ E L+ +A+ + + K F + +Q +K A K+ E +P+ LT Sbjct: 551 PELTAKWERELELIAHGQGDAK----RFMAGIREQANKWVTAVKN-ETKEYKPHN--LTH 603 Query: 597 IDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNAL 656 CP CG+ + G L CS + E + E A +N Sbjct: 604 SRCPECGKLLMEVKGKRGKSLVCS------------------DRECSYRRQAEPALSN-- 643 Query: 657 RAKRRCPKCGTAMDSY 672 +RCP+C M+ + Sbjct: 644 ---KRCPQCHKKMEIH 656 >UniRef50_Q5V1P3 DNA topoisomerase I n=1 Tax=Haloarcula marismortui RepID=Q5V1P3_HALMA Length = 1364 Score = 178 bits (452), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 143/443 (32%), Positives = 226/443 (51%), Gaps = 39/443 (8%) Query: 73 VDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGD-D 131 V+P +A P +E +V+ LKQLA +AD +ATD DREGE I E+I + D Sbjct: 64 VEPVELIDADVTKEPTQENIVTTLKQLAREADEATIATDYDREGELIGKEAYELIREETD 123 Query: 132 ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGL 191 A RV F+ IT+ +R AF P +++ D A +AR+ +D V G ++ L AR L Sbjct: 124 APVDRVRFSSITEREVRDAFANPDDIDFDLAAAGEARQIIDLVWGAALTRFLSLS-ARQL 182 Query: 192 -----SAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPF 246 S GRVQS ++L+V+REREI+AF PE++WE+ A +G Q + +D Sbjct: 183 GDDFISVGRVQSPTLKLIVDREREIQAFDPEDYWEIFADLQK-NGSGFEAQYFYDDD--- 238 Query: 247 RPVNKEQTQAAVSLLEKARYSVLEREDKPT---------TSKPGAPFITSTLQQAASTRL 297 KE + V Y+ L D T T P PF T+ AAS+ L Sbjct: 239 ---GKEAERVWVEDDADDAYADLTNVDAATVTSVRRRTRTDSPPTPFNTTAFISAASS-L 294 Query: 298 GFGVKKTMMMAQRLYEAGYITYMRTDST----NLSQDAVNMVRGYI-SDNFGK--KYLPE 350 G+ ++ M +A+ LY GYITY RTD+T +L +DA ++ ++ + +FG+ + L E Sbjct: 295 GYSAQQAMSIAEELYTTGYITYPRTDNTVYPDDLEEDA--LLDEFVGAGHFGEDAEALLE 352 Query: 351 SPNQYASKENSQEA-HEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYD 409 + A++ + + H I P+ L D D ++Y+L+ R+F A A ++ Sbjct: 353 QDDITATEGDEETTDHPPIHPTGEIPPKADLSD---DEWEIYELVVRRFFATVAEAATWE 409 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 + AG LKA G+ L G+ +V P E+ + P V +G+ L + E+ Sbjct: 410 HLRVVADAGGRSLKANGKRLVEPGYHEVYP-YSSASENHV-PDVEEGEELAISEVRMEAK 467 Query: 470 FTKPPARFSEASLVKELEKRGIG 492 T+PP R+ ++ L++ +E +G+G Sbjct: 468 QTQPPRRYGQSRLIQTMEDKGLG 490 Score = 61.2 bits (147), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 73/285 (25%), Positives = 116/285 (40%), Gaps = 51/285 (17%) Query: 495 STYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 ST + I + DRGY+ + R M V + EE +++ + TAQ+E + +A Sbjct: 1030 STRHNSIEKLYDRGYIEGDPPRPTTLAMA--VVEAAEEFADHVVSDEMTAQLEADMTAIA 1087 Query: 555 NHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMV---LTSIDCPTCGRKMGIRTA 611 N EA V D + D+ EE G + + T CP CG M +R + Sbjct: 1088 NGEATLDDVADESREMLKRVFDELRDSREEIGEHLQESLKADKTLGPCPKCGEDMLVRRS 1147 Query: 612 STG-VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMD 670 G F+GC G+ C+ T+ L P VLE E + K + D Sbjct: 1148 RQGSYFVGCDGFP-----ECRNTLPL-PSTGEPQVLEDHCEEHDMHHVKMLAGR-----D 1196 Query: 671 SYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEM-------HLKMG 723 ++ +H C P C+ + +E E + G C +CGSE HL+ G Sbjct: 1197 TF-------VHGC---PRCEAEKADESEDEVIG------PCPECGSEHDGDLAIKHLRSG 1240 Query: 724 RFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD 767 + + CT +C + + RNG+++ + E CE+ D Sbjct: 1241 --SRLVGCTRYPDCDYSLPLPRNGDIS--------VTEAFCEEHD 1275 >UniRef50_Q12Y06 DNA topoisomerase n=1 Tax=Methanococcoides burtonii DSM 6242 RepID=Q12Y06_METBU Length = 780 Score = 178 bits (452), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 180/766 (23%), Positives = 334/766 (43%), Gaps = 90/766 (11%) Query: 30 SVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGV----------DPWHNW 79 + I + + GSA + D S ++ G+L MG+ + +HNW Sbjct: 12 AAAQISTILSGGSAKRSIVDGVSVYEFQRD-----GSLWKIMGLAGHIMGYDYPEEFHNW 66 Query: 80 E-----AHYEVLPGKE----KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG- 129 A + P K+ S + ++++ AD + LA D DREGE I + + + Sbjct: 67 RDVDPAALLDTDPVKQINKASFGSAILKISKGADLLVLACDFDREGENIGFEAKSIAEKV 126 Query: 130 DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI-- 187 DA R F+ ++K+ I +AFN E + + + +AR+ +D +G + + + Sbjct: 127 SDATVKRARFSSLSKSEIEKAFNDLVEPDENMAMSAEARQILDLKMGASFTRFVTLSVRE 186 Query: 188 ---ARG-LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 +G LS G Q+ V ERE I+ F +FW+++ T + + + H+ Sbjct: 187 RARTKGVLSIGPCQTPTCGFVYERELAIRKFDSRDFWKIEGVFTGKGADIIGV---HRGG 243 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLERED-KPTTSKPGAPFITSTLQQAASTRLGFGVK 302 + +KE+ A L+ + +V+ ++ K + P P T+ + AS LG Sbjct: 244 HIY---DKEKAAAIFKKLKGCKTAVISKKTVKEMNTNPPFPLNTNEFLKRASKYLGVSPD 300 Query: 303 KTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGYISDNFGK-KYLPESPNQYASKE 359 + + +A++LY +G+ +Y RT++ + D ++++G+ ++ L S + Sbjct: 301 QALEIAEQLYLSGFTSYPRTETNMYADDMDFASILKGFTKGDYQDFALLLLSQKAIVPRN 360 Query: 360 NSQEAHE--AIRPSDVNVMAESLKDMEAD-AQKLYQLIWRQFVACQMTPAKYDSTTLTVG 416 ++ H+ I P E + ++ A +Y LI R F+A + PA ++ T + Sbjct: 361 GKKDGHDHPPIHPIKAGSRMEVERAIKMPRAWDVYDLIVRHFIANLLPPAVFEKTRFEIT 420 Query: 417 AGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPAR 476 D + G I + GW V P + +D+ILPA++ G+ L + ++T + T PP R Sbjct: 421 MEDELFDSTGSIQKNAGWLAVYPFEKP--QDKILPALDLGEVLDVKKITNIKSQTTPPKR 478 Query: 477 FSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE 536 +EA L+ ++K GIG +T S I T + RGY V+ + G + D L + Sbjct: 479 LTEAELLTLMDKHGIGTKATAPSHIETNKKRGYFEVKGKTIAILDTGFTLMDALNSSVPI 538 Query: 537 LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTS 596 L+ D + +E+ + V + +++ L+ S + + + + + ++ T Sbjct: 539 LVKPDIRSSIESLIQDVEDGNKKFELALEEGTSLIKEMYSQLLSNRD---LMVTRIAGTI 595 Query: 597 ID-------------CPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVL 643 D C C R + I + G F+GC+GY +CK T L P+ L Sbjct: 596 TDEAVEADKKSHIGKCNECERVLRIVSTDKGRFVGCTGYP-----QCKNTFPL-PKTGAL 649 Query: 644 NVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKG 703 A++ R C K G A+ L + G P C ++E+ + Sbjct: 650 -----------AVQRSRTCKKGGAAV---LKVGSKYFWAVGIGP-CFSCDMEK-----EC 689 Query: 704 YDGPIV-ECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEV 748 Y IV EC C + L + +++ CT + C +T+ + +NG + Sbjct: 690 YPPEIVGECPACDGQTFLITTKDSRFLGCT-KRCGHTQSVPKNGRL 734 >UniRef50_Q53VZ7 Reverse gyrase n=2 Tax=Thermus thermophilus RepID=Q53VZ7_THET8 Length = 1116 Score = 178 bits (451), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 179/590 (30%), Positives = 263/590 (44%), Gaps = 93/590 (15%) Query: 5 LVIVESPAKAKTINKYLGSD-------------------YVVKSSVGHIRDLPTSGSAAK 45 +V+VESP KA+T+ + G VV ++ GH+ DL G Sbjct: 557 VVVVESPNKARTLAGFFGRPMRRYLPGLVVYEALSEEGYLVVTATRGHVTDLALRGGLY- 615 Query: 46 KSADSTSTKTAKKPKKDERGALVNRMGVDPW-HNWEAHYEVLPGKEKVVSELKQLAEKAD 104 T A +P+ A DP+ + A P +++ + L+ LA +A Sbjct: 616 ----GVETAPAYRPRYHPLRACPEGSVPDPFCPDGRASR---PDRDRALEALRSLALEAQ 668 Query: 105 HIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNA 164 LATD D EGE IAW + + +R F+ +T A +A +P E+ D V A Sbjct: 669 DFLLATDPDTEGEKIAWDVLLALRAFGKEVARGEFHAVTPRAFLEALRRPREVKEDLVEA 728 Query: 165 QQARRFMDRVVGYMVSPLLWKKIAR-GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD 223 Q RR DR +G+ +S L K + R LSAGRVQ+ + V+ RERE + +P F EV Sbjct: 729 QMVRRIADRWIGFALSEDLQKLLRRRSLSAGRVQTPVLGWVIAREREARTRLP--FTEV- 785 Query: 224 ASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 + L L+ + K +T L E P P Sbjct: 786 ------ALRGLTLRFPGEV--------KAKTLLLEVLEEGE-----------REQNPLPP 820 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNF 343 +IT L AS GF V + M +AQ L+EAG ITY RTD+T ++ + + + R I F Sbjct: 821 YITDALLADASKE-GFRVPEAMALAQDLFEAGLITYHRTDATRVAPEGMALARRLIEARF 879 Query: 344 GKKYLPESPNQYASKENSQEAHEAIRPS---------DVNVMAESLKDMEADAQKLYQLI 394 G PE E AHEAIRP+ + ++A +L EA +LY LI Sbjct: 880 G----PEHARPRPWGEGG--AHEAIRPTRLLWPEDLEEAGLLA-ALPLSEAHG-RLYSLI 931 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRI-LRFDGWTKVMPALRKGDEDRILPAV 453 +R+F+A QM PA+ L G+ + R+ L F G+ +V P D L A Sbjct: 932 FRRFLASQMAPARVREKRLRACLGEACQELTLRVALLFPGFARVWPL----GLDPDLEAG 987 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513 A V L A AR++E LV E+++RG+GRPSTYA+ + + +R YV Sbjct: 988 PYAVAPKTVRLPKA-------ARYTEGELVAEMKRRGLGRPSTYAATVERLLERRYVVRR 1040 Query: 514 NRRFYAEKMGE----IVTDR--LEENFRELMNYDFTAQMENSLDQVANHE 557 ++GE ++T+R L R + FT ++E +D+V E Sbjct: 1041 GPFLVPTRLGERVYALLTERPPLAPVARRFVGEAFTREVEAWMDRVEAGE 1090 >UniRef50_B9MRC8 Reverse gyrase n=1 Tax=Anaerocellum thermophilum DSM 6725 RepID=B9MRC8_ANATD Length = 1122 Score = 178 bits (451), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 171/608 (28%), Positives = 284/608 (46%), Gaps = 85/608 (13%) Query: 5 LVIVESPAKAKTINKYLG----------SDY---------VVKSSVGHIRDLPTS-GSAA 44 L+IVESP KA TI+K+L S Y ++ +S GH+ DL T G Sbjct: 563 LMIVESPTKADTISKFLEKASTRRYGKLSVYESITPEGILLITASKGHVYDLETKKGLHG 622 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNW-EAHYEVLPGKEKVVSELKQLAEKA 103 + D K R N D + + + K++++ L++LA + Sbjct: 623 VEYHDGKFIPYYNSIK---RCMKCNTQFTDELDSCPKCASNTIDDKKEILKTLRELALEV 679 Query: 104 DHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVN 163 D + +ATD D EGE I+W + + I ++ R+ +EIT+ + A P + N + V Sbjct: 680 DEVLIATDPDVEGEKISWDISQYIKPANSNIKRIEMHEITRYGLDSALRNPRQFNTNLVK 739 Query: 164 AQQARRFMDRVVGYMVSPLLWKKI-ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 +Q RR DR VG+ +S L + + LSAGRVQS + +VERE+E Sbjct: 740 SQIVRRIEDRWVGFELSSKLQENFKSYNLSAGRVQSTILGWIVEREKE------------ 787 Query: 223 DASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 + + + L L+ + N + + E+ +A + E K A Sbjct: 788 -YAKSEKTFTLLKLENGY-NLEIEGEIECERVKAQIV------------EQKIEEISAPA 833 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDN 342 PF TS+L AS +L V + M + Q L+E G+ITY RTDST +S N+ R ++ + Sbjct: 834 PFSTSSLLSLASQKLNLDVPRIMEILQFLFEHGFITYHRTDSTRISVTGQNIARMFL-EK 892 Query: 343 FGKK--YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDM---------EADAQKLY 391 GKK +LP S ++ AHEAIRP + E LK++ + K+Y Sbjct: 893 VGKKELFLPRSF-------GNEGAHEAIRPVK-PISPEELKELAYEKYTQGISQNHIKVY 944 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRI-LRFDGWTKVMPALRKGDEDRIL 450 QLI+ +F++ QM K + D + + + +GW + +P +I Sbjct: 945 QLIFNRFMSSQMKNPKVLVQKVHFKINDIEIVKDIPVKVEEEGWLEFLPM-------QIY 997 Query: 451 PAVNKGDALTLVELTPAQHFTKPPAR-FSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 P D LT + + K + +++ASL+ E++++ IGRPSTYA ++ T+ RGY Sbjct: 998 PLFENKDY----SLTDKRSYKKHTIQLYTQASLIDEMKQKNIGRPSTYAKMVETLFKRGY 1053 Query: 510 VRVEN-RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 V ++ RR + +G+ V L + + E +N T ++E +D V + +++ VL + Sbjct: 1054 VFEDSFRRIRSTSLGKKVYSYLSQKYGEYVNEQTTRELEKLMDIVEEGKRDYQEVLLELY 1113 Query: 569 SDFTQQLD 576 +D + L+ Sbjct: 1114 NDISVLLN 1121 >UniRef50_O29238 Topoisomerase n=3 Tax=Archaeoglobaceae RepID=RGYR_ARCFU Length = 1054 Score = 177 bits (449), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 171/629 (27%), Positives = 278/629 (44%), Gaps = 148/629 (23%) Query: 4 ALVIVESPAKAKTINKYLGSDYV-------------------VKSSVGHIRDLPTSGSAA 44 AL IVESP KA+ I+++ G V V +S+GH+ DL T+ Sbjct: 507 ALFIVESPTKARQISRFFGKPSVKVLDGAVVYEIPMQKYVLMVTASIGHVVDLITN---- 562 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMGV----------DPWHNWEAHYEVLP--GKEKV 92 + G LVN V D + + E P G E V Sbjct: 563 ----------------RGFHGVLVNGRFVPVYASIKRCRDCGYQFTEDRESCPKCGSENV 606 Query: 93 ------VSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNA 146 + L++LA A+ + + TD D EGE IAW L+ ++ G A R F+E+T+ A Sbjct: 607 DNSRSRIEALRKLAHDAEFVIVGTDPDTEGEKIAWDLKNLLSGCGA-VKRAEFHEVTRRA 665 Query: 147 IRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVV 205 I +A +++ + V AQ RR DR +G+++S LW++ R LSAGR Q+ + ++ Sbjct: 666 ILEALESLRDVDENLVKAQVVRRIEDRWIGFVLSQKLWERFNNRNLSAGRAQTPVLGWII 725 Query: 206 EREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKAR 265 +R +E S E + + D ++E+ + L+E Sbjct: 726 DRFQE-------------------SRERRKIAIVRDFDLVLEH-DEEEFDLTIKLVE--- 762 Query: 266 YSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDST 325 ERE+ T P P+ T T+ A+ L F VK+TM +AQ L+E G ITY RTDST Sbjct: 763 ----EREELRT---PLPPYTTETMLSDANRILKFSVKQTMQIAQELFENGLITYHRTDST 815 Query: 326 NLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPS------DVNVMAES 379 +S + + Y+ D+F + ES AHE IRP+ DV + + Sbjct: 816 RVSDVGQRIAKEYLGDDFVGREWGESG-----------AHECIRPTRPLTRDDVQRLIQE 864 Query: 380 ----LKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWT 435 ++ + + LY LI+R+F+A Q P F++ + + FDG T Sbjct: 865 GVLVVEGLRWEHFALYDLIFRRFMASQCRP--------------FKVVVKKYSIEFDGKT 910 Query: 436 KVMPALRKGDEDRILPAVNKGDALTLV-------ELTPAQHFTKPPAR-------FSEAS 481 +E+RI+ A +G A L EL K + F+++ Sbjct: 911 --------AEEERIVRA--EGRAYELYRAVWVKNELPTGTFRVKAEVKSVPKVLPFTQSE 960 Query: 482 LVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYD 541 +++ +++RGIGRPSTYA+I+ + R YV + R K+G V L + + ++ D Sbjct: 961 IIQMMKERGIGRPSTYATIVDRLFMRNYVVEKYGRMIPTKLGIDVFRFLVRRYAKFVSED 1020 Query: 542 FTAQMENSLDQVANHEAEWKAVLDHFFSD 570 T +E+ +D + E ++ L+ +++ Sbjct: 1021 RTRDLESRMDAIERGELDYLKALEDLYAE 1049 >UniRef50_Q8R979 Topoisomerase n=14 Tax=Bacteria RepID=RGYR_THETN Length = 1117 Score = 177 bits (448), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 170/616 (27%), Positives = 274/616 (44%), Gaps = 91/616 (14%) Query: 1 MGKALVIVESPAKAKTINKYL--------GSDYV-----------VKSSVGHIRDLPT-S 40 M ++IVESP KA+TI+K+L GS V + +S GH+ DL T + Sbjct: 553 MKSRMIIVESPTKAQTISKFLEKSSTRRYGSLMVHESITQEGILLLTASKGHLYDLETKT 612 Query: 41 GSAAKKSADSTSTKTAKKPKK-DERGA-LVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQ 98 G + D K+ GA + + P+ N + + K+K++ L+ Sbjct: 613 GLHGVEINDGRFIPYYNSIKRCSSCGAQFTDELPRCPYCNSDK----IDDKKKILEALRD 668 Query: 99 LAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELN 158 +A + D + +ATD D EGE I W + + I + R+ +EITK +A + Sbjct: 669 IAMEVDEVIIATDPDVEGEKIGWDISQYIKPVNKNVQRIEMHEITKFGFDKAIRNRRNCD 728 Query: 159 IDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREIKAFVPE 217 ++ V +Q RR DR VG+ +S L K LSAGRVQS + ++E+E E Sbjct: 729 VNLVKSQIVRRIEDRWVGFELSLRLQKNFQNSNLSAGRVQSTVLGWILEKEIE------- 781 Query: 218 EFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTT 277 + Q T N F K + + + L Sbjct: 782 ----------HSKSKKTVTQFTLDNGFKFEVDGKIDVDEVEVEIVEEKEQALS------- 824 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 P PF T +L AAS + V++ M + Q L+E G+ITY RTDST +S + R Sbjct: 825 --PLPPFNTPSLLTAASQQFKLPVQQIMEILQTLFELGFITYHRTDSTRISSTGQKIARS 882 Query: 338 YISDNFGKKYLPESPNQYASKENSQE-AHEAIRPSD-----------VNVMAESLKDMEA 385 Y+ + GK L + +E +E AHEAIRP +A L M Sbjct: 883 YL-EKIGKITL------LSEREWGKEGAHEAIRPVKPISPEELSEFITEKIAAYLSPMHI 935 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRI-LRFDGWTKVMP-ALRK 443 K+Y LI+ +F+A QMT + + + G F+++ + L+ +GW P + Sbjct: 936 ---KVYSLIFNRFMASQMTSPVVINQKILIKNGSFQVEREVPVKLQEEGWNIFNPITVYT 992 Query: 444 GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 503 E++ V+K + T F++ASL++E++KR IGRPSTYA I+ Sbjct: 993 PFEEKKYSVVSK-----------RTYTTHTVPLFTQASLIEEMQKRNIGRPSTYAKIVDI 1041 Query: 504 IQDRGYVRVEN--RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWK 561 + R Y+ +E+ +R +G V L E + +N + T Q+E ++ V E +++ Sbjct: 1042 LFKRKYI-IEDVYKRLRTTALGRKVYSYLSERYMNYINEETTRQLEKLMESVETGEKDYQ 1100 Query: 562 AVLDHFFSDFTQQLDK 577 +VL + + + + L K Sbjct: 1101 SVLKNLYEELNEILIK 1116 >UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LTI8_DESBD Length = 620 Score = 176 bits (446), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 165/604 (27%), Positives = 266/604 (44%), Gaps = 84/604 (13%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M + L+I E P+ A+ + LG ++V +VGH+ ++ + A + A Sbjct: 1 MPRTLIIAEKPSVARELAGVLGVKGRGDGFLQGPGHIVTWAVGHLVNI--AEPAEQNPAW 58 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQ--LAEKADHIY 107 S + P R L +LP K ++ L + D + Sbjct: 59 SGRWSMRQLPMLPSRFTL----------------GILPSTAKQYEIIRNFLLDDDIDSVV 102 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQ 165 ATD REGE I + ++ G R+ N++T+ +++AF GE + +A Sbjct: 103 NATDAGREGELIFRRIY-LLAGSTKPIKRLWANDMTEKGLQKAFAGMVSGEEKRNLGHAA 161 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D +VG S L + ++ GRVQ+ ++L+VER REI+ F+P ++W V+ Sbjct: 162 FARAEADWLVGMNFSRLFTLRAGSLITVGRVQTPVLKLLVERRREIENFLPRDYWTVEGE 221 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 A + K + E+ Q V +VLE E K KP F Sbjct: 222 FAHEGETFKATWFAAPDFKDSKIWQVEEGQTVVQACAGKDGAVLEMEKKKGRQKPPLLFD 281 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAV-----NMVRGYI 339 + LQ+ A++RLGF ++T+ +AQ LYE ITY RTDS L+++ NM Y Sbjct: 282 LTNLQKEANSRLGFSAQQTLSIAQDLYEKRKLITYPRTDSRYLTKELFAECLENMRAVY- 340 Query: 340 SDNFGKKYLPESPNQYASKENSQEA--------------HEAIRPSDVNVMAESLKDMEA 385 + PE A+ N ++A H AI P+ + +L E Sbjct: 341 ------AHFPEISQSAAA--NIKDAKKKFECVNDKKVSDHHAIIPTTLRANPATLGKEE- 391 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD 445 +Y++I R+F A M A + S+TL +G R +A G+I + GW + P + Sbjct: 392 --WAIYEMICRRFAAAFMDDATFASSTLWIGVEGHRYRATGKIFQDKGWLEAEPW--RAS 447 Query: 446 EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KR 489 ED LP + KG A+T L H TKPPA F++A+L+ +E +R Sbjct: 448 EDNPLPNLRKGAAVTAQSLDLVAHKTKPPAHFTDATLLAAMETAGKLIDDEELRDAMKER 507 Query: 490 GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENS 549 G+G P+T A II T+ R Y+ + +R A +G D + ++ + + T + E Sbjct: 508 GLGTPATRAQIIETLLARKYIGKDGKRLVATDLGCWAVDVVCSMIPQVASPELTGEWEKR 567 Query: 550 LDQV 553 L ++ Sbjct: 568 LKEM 571 >UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LPU9_9EURY Length = 764 Score = 176 bits (445), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 176/689 (25%), Positives = 313/689 (45%), Gaps = 66/689 (9%) Query: 89 KEKVVSE-LKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAI 147 KEK ++ L+ LA+ AD + +ATD DREGE I + R F+ +T+ I Sbjct: 101 KEKGIANILRTLAKDADMLIIATDYDREGELIGVESLSITNFKGP-VKRAKFSALTEREI 159 Query: 148 RQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG----LSAGRVQSVAVRL 203 AF+ ++N + +A + R+ +D G ++ + +R LS GRVQS + L Sbjct: 160 ENAFSNLVDVNYNLASAAETRQKIDLAWGASLTRFISLASSRRGKDYLSVGRVQSPTLAL 219 Query: 204 VVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEK 263 +V+RE+EI+ FVP +W + H ++ ++ + V + Sbjct: 220 IVKREKEIENFVPTPYWNIKGLFFKRRN----FSGMHISNPFWKEEEVMEVYEKVKDTKS 275 Query: 264 ARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTD 323 A+ +ED+ +P PF T+ A T+LGF K M +A+ LY GYI+Y RTD Sbjct: 276 AKVLDFVQEDRKI--RPPIPFNTTEFLSEA-TKLGFSAAKAMRLAEELYMGGYISYPRTD 332 Query: 324 STNLSQD-AVNMVRGYISDNFGKK---YLPESPNQYASKENSQEA-HEAIRPSDVNVMAE 378 +T + ++N + + + K+ L + +Y ++ + H I P+ Sbjct: 333 NTVYPKTLSINSILKSLEKSKFKEEALKLQKERRRYPTRGKKESTDHPPIVPT------- 385 Query: 379 SLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM 438 ++E D K+Y+L+ R+F+A +Y + + + D +A+G+ L +GW Sbjct: 386 RGANLEGDKGKIYELVVRRFMATLAQDLEYRESKVKLAVKDEIFEAKGKELVNEGWLYYY 445 Query: 439 PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYA 498 P +R +E +P + GD + + ++ + T+PPAR++++SL++E+EK +G ST A Sbjct: 446 PYVRFEEEK--IPILRIGDEVKVKKIEIERKETRPPARYTQSSLIREMEKLNLGTKSTRA 503 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 II + +RGYVR R ++G+ + + LE N +++ D TA++E +D++ Sbjct: 504 EIIQKLFERGYVRGNPIR--PTQLGKALIESLEGNNVDVIKPDMTARLEMDMDEIEKGSK 561 Query: 559 EWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSI-DCPTCGRKMGIRTASTGVFL 617 + V+ + L E++ G + I +CP G+ + + V Sbjct: 562 APEFVVKESREMLKKILSSLEENRSTVGSNIKSSMRREIGECPDGGKLIYLERKRLVV-- 619 Query: 618 GCSG------YALPPKERC-----KTTINLVPENEVLNVLEGEDAETNALRAK------- 659 C Y LP K I +P +++ G+ E L +K Sbjct: 620 -CENDGETKYYNLPKTGHIEFLDKKCPICGLPLIKIIR--RGQSPEIRCLNSKCEYNRKK 676 Query: 660 ---RRCPKCGTAMDSYLIDPKRKLHVCGNNPTCD-GYEIEEGEFRIKGYDGPIVE-CEKC 714 +CPKCG + ++ C N P CD Y + + +G P E C C Sbjct: 677 DIVGKCPKCGGDLVIRQSKNGKRFIGCSNYPKCDVTYSLPQ-----RGKIIPTGEVCPYC 731 Query: 715 GSEMHLKMGRFGK--YMACTNEECKNTRK 741 G+ + L + + GK + C N +C+ R+ Sbjct: 732 GAPL-LILRKKGKKDWKFCPNIKCEYNRR 759 >UniRef50_A2BLB8 Reverse gyrase n=2 Tax=Hyperthermus butylicus RepID=A2BLB8_HYPBU Length = 1183 Score = 174 bits (441), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 169/600 (28%), Positives = 271/600 (45%), Gaps = 85/600 (14%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDL------PTSGSAAKKSADSTSTKTAKK 58 L++VESP KAKTI + G V+ +G + P SG + +T+ Sbjct: 585 LIVVESPTKAKTIAGFFGRP--VRRRIGSVVVYETTFYNPVSGKIHVAAIAATAGHVYDL 642 Query: 59 PKKDE--RGALVNRMGVDPW-----------HNWEAHYEVLP--------GKEKVVSELK 97 DE G + + GV P H + + +V P KE V+ L+ Sbjct: 643 TIDDEGIYGVELGKNGVSPIYKPIKRCLSCGHQFSSSSQVCPRCGSSNIVSKEDVIGALR 702 Query: 98 QLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL 157 QLA + + +Y+ATD D EGE IA+ + ++ + R+ +EIT++ + +A P E+ Sbjct: 703 QLAIENEVVYIATDPDVEGEKIAYDIYLLLRPYARKIMRIELHEITRSELNRALANPREV 762 Query: 158 NIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREIKAFVP 216 ++ AQ RR DR +G+ +S LW+ + L AGRVQ+ + ++ER E ++ + Sbjct: 763 DVRLAEAQMVRRIEDRWIGFGLSQHLWQVFGKNWLGAGRVQTPVLGWIIERYSEWRSNLG 822 Query: 217 EEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPT 276 + P G + + + E VS E++ Sbjct: 823 YNLY-----IRLPGGPLVKIHYDSASGAREAAAAAENGVRVVS-----------VEEEVV 866 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 P P+ T +L AS G+ +KTM +AQ L+EAG ITY RTDST++S ++ R Sbjct: 867 EINPPPPYTTESLIYDASRLYGYPAQKTMRVAQELFEAGLITYHRTDSTHVSGLGQHIAR 926 Query: 337 GYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEA----------- 385 Y+ + L P + Q HEAIRP+ + AE+L+ M A Sbjct: 927 LYLESREDAELL--QPRSW----GPQGHHEAIRPTR-PIDAEALRRMVALGDLRVPVTLR 979 Query: 386 -DAQKLYQLIWRQFVACQMTPAKYD--STTLTVGAGDFRLKARGRILRFDGWTKVMPALR 442 +LY LI+R+F+A QM PAK L V ++ LR +G+ K P R Sbjct: 980 ESHYRLYDLIFRRFIASQMKPAKLKRRRIRLEVAGSQVEIEVYTAALR-EGYHKYYPYPR 1038 Query: 443 KGDEDRILPAVNKGDAL----TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYA 498 L +V GD L LV + ++ +V + +RG+GRPSTYA Sbjct: 1039 L---HMALDSVKPGDVLRPERILVRRGSTVYL------YTHGEIVSLMRERGLGRPSTYA 1089 Query: 499 SIISTIQDRGYVRVEN---RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 II ++ GYV +E+ RR K+G V + LE + L++ + T ++ ++++A+ Sbjct: 1090 KIIDALERHGYV-IESKYRRRLVPTKLGIEVYEYLESRYGSLVSEERTRKLYRDIEEIAS 1148 >UniRef50_Q4QCK3 DNA topoisomerase 1A n=6 Tax=Trypanosomatidae RepID=Q4QCK3_LEIMA Length = 812 Score = 174 bits (440), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 170/688 (24%), Positives = 286/688 (41%), Gaps = 130/688 (18%) Query: 5 LVIVESPAKAKTINKYLGSDYVV----------------------KSSVGHIRDLPTSGS 42 LVIVESP K + L V+ ++ GH L Sbjct: 12 LVIVESPNKVIKVEGLLSDPKVIPDWSFNNSKLRAISTGAEKAIAMATTGHFMSLKELTW 71 Query: 43 AAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK 102 + + S+ ++ A P G LV+ + +E++PG+ + + EK Sbjct: 72 SPQSSSPASGVTAADFPAN---GLLVS---------FSLEWELIPGRRIQDTVSHYIEEK 119 Query: 103 ADH---IYLATDLDREGEAIAWH----LREVIGGDDARYSRVVFNEITKNAIRQAFNKPG 155 AD+ I +ATD DREGE IA H +R + +A ++R + IT + IR+A + Sbjct: 120 ADNLTEIIVATDPDREGELIAVHAQNLIRRMFPQLNAPFTRAYMHSITADGIRRAMEERH 179 Query: 156 E-LNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAF 214 E + + NA +AR MDR+ G++ S ++ + S GRVQ+ A+ L+ +RE +IK++ Sbjct: 180 EAFDYNLANAAEARHAMDRIFGFLGSSVVRYANPQMRSIGRVQTPALILINDREDKIKSY 239 Query: 215 VPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSL-------------- 260 + E AST HQ V + A + Sbjct: 240 L-----ESHASTFEIQVVCYFTSKHHQRFSQVVKVTPARKGGAAPVDWSDKATVKQRCEQ 294 Query: 261 --LEKARYSVLEREDKP--TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY 316 L A + + KP T + P PF +TL A+ +L + Q L++ GY Sbjct: 295 WALSSATHFSVSPGAKPQETVTPPPKPFTMATLIARANRQLHYSSDMVSSCLQDLFQMGY 354 Query: 317 ITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE------------SPNQYASKENSQEA 364 ITY RTDST + + + + + GK+ L E + + A+ N ++A Sbjct: 355 ITYPRTDSTRIDESILPSIYAAVRREHGKRLLQEQDGPSKAGVRRSTAQKEAADANVEDA 414 Query: 365 HEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG-----D 419 HEAIRP++++ E L + A + +Y L+ R +A M P K + + V + Sbjct: 415 HEAIRPTNIDTTVEELGAVSAPMKHIYDLVRRNTMAVHMIPMKTERIVVLVACKAANGEE 474 Query: 420 FRLKARGRILRFDGWTK---------------------------VMPALRKGDEDRIL-- 450 + +G+ + GW+ V+P++ + I+ Sbjct: 475 VEFELQGKHVVEPGWSAAFHGSKGTATPVTETDQDVEAVEDGGVVVPSISDDEFKAIMDI 534 Query: 451 -------PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 503 V KG ++ L A++ PP FSE L+++L+ G+GRPSTY I+ T Sbjct: 535 AAQRGGGTGVQKG-SMQLESAQVAENRPSPPLPFSEGGLIEQLKNNGVGRPSTYPMIVKT 593 Query: 504 IQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN-------- 555 + R Y+ V R +G ++ D F +++ FT+ E LD++A Sbjct: 594 LLARNYITVNKGRCETTPVGRMLVDTSRATFPSIVDIGFTSAFEKKLDRIAKPRSTKELA 653 Query: 556 ---HEAEWKAVLDHFFSDFTQQLDKAEK 580 + ++ VL F S+F + +A K Sbjct: 654 LPPNVSDADYVLSSFISNFLNYVTEATK 681 >UniRef50_A4YIX2 Reverse gyrase n=2 Tax=cellular organisms RepID=A4YIX2_METS5 Length = 1220 Score = 173 bits (438), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 167/648 (25%), Positives = 270/648 (41%), Gaps = 120/648 (18%) Query: 4 ALVIVESPAKAKTINKYLGS----DY---------------VVKSSVGHIRDLPTS---- 40 L+IVESP KAKTI+ + D+ +V SS GH+ DL T Sbjct: 609 VLLIVESPNKAKTISNFFSRPSIRDFDGLRVYETVIGDKILMVTSSGGHVYDLTTKDLGV 668 Query: 41 -GSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYE----------VLPGK 89 G K + D K+ E G H + + E + K Sbjct: 669 YGVEVKSNGDVNVIPFYNTLKRCENG-----------HQFTEYAEGGKCPICMSTNVRDK 717 Query: 90 EKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQ 149 ++ L++L +AD + + TD D EGE IAW L + ++ R F+E+T+ AI + Sbjct: 718 RSAINVLRRLVLEADEVLIGTDPDVEGEKIAWDLYLNLKPFNSNIFRAEFHEVTRRAITE 777 Query: 150 AFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL----WKKIA-------------RGLS 192 A N P +I+ + +Q RR DR +G+ +S L WK+ R LS Sbjct: 778 ALNSPRTFSINMLRSQLVRRIEDRWIGFKLSNKLKEEFWKEYCTKTLGNKDCDTENRNLS 837 Query: 193 AGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKE 252 AGRVQ+ + V+ R EE+ + L + + Q Sbjct: 838 AGRVQTPVLGWVISRY--------EEYLRTKRTMYVAKAGNLNILIPKQQ---------- 879 Query: 253 QTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLY 312 + K + + E K T P + T T AS ++ M +AQ L+ Sbjct: 880 ----GIRKNSKIKIVIQSAERKQDTLGPFPAYTTDTYLSDASGFFFISAQEAMRIAQDLF 935 Query: 313 EAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY----LPESPNQYASKENSQEAHEAI 368 E G ITY RTDST +S + + Y+ D G++Y +P S + AHEAI Sbjct: 936 ENGLITYHRTDSTRISNVGIGIAESYLKDLLGERYREIFVPRSWGEGG-------AHEAI 988 Query: 369 RPS------DVNVMAES-----LKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA 417 RP+ + M E K + + +LY +I+R+F++ Q+ P + L + A Sbjct: 989 RPTRPLNGEQLRAMVEQGEIEPSKRLTYNHYRLYDMIFRRFLSSQLVPLVVEKEILQISA 1048 Query: 418 --GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTL---------VELTP 466 GD LK L ++ + E +P + G+ L ++ Sbjct: 1049 KKGDETLKLESDTLEIVTNVRLSKDVPIPSEILYIPFRSIGETLLTQIKDKLPAEIDAVI 1108 Query: 467 AQHFTKPP-ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV--RVENRRFYAEKMG 523 F K A +++ LV +++R IGRPSTYA IIST+ RGYV ++ +R K+G Sbjct: 1109 TSSFQKSDHALYTQGELVSLMKQRKIGRPSTYAFIISTLLKRGYVFETMKVKRLIPSKLG 1168 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 + V + L + ++ D T + +D + + +++ VL +++ Sbjct: 1169 QHVYEFLNSRYSNFVSEDRTRSLLERMDLIEEGKEDYRQVLKQLYNEI 1216 >UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=C4L3B0_EXISA Length = 708 Score = 172 bits (436), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 172/636 (27%), Positives = 285/636 (44%), Gaps = 99/636 (15%) Query: 76 WHNWEAHYEVLP------------GKEKVVSELKQLAE--KADHIYLATDLDREGEAIAW 121 W +W+ YE LP GK K +K+ + +A+D +REGEAI Sbjct: 62 WKSWK--YEALPIVPERFDYRISKGKSKPFYAIKKWLHDRSITDVIIASDAEREGEAIV- 118 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRFMDRVVGYMV 179 L + G+ +R+ + +T+ A+ + F++ PGE I + +R D +VG Sbjct: 119 RLILRLAGNKKPLARLWISSLTEQAVDRGFSQLLPGEQTIPYYHEAMSRACADWLVGMNA 178 Query: 180 S---PLLWKKIA--RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEAL 234 S L K I S GRVQ+ + L+V REREIK FVPE ++EV+A+ G Sbjct: 179 SRAYTTLLKTIGIEDVFSLGRVQTPTLALIVNREREIKQFVPEPYFEVEATLAKGRG--- 235 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLLE-KARYSVLEREDKPTTSKPGAPFITSTLQQAA 293 + + K + +E+ A V A +++E+K +P F S LQ A Sbjct: 236 TFKAKYTFGKTTKLKTREEADAVVKRASGTAIVKTIDKEEK--IEQPPFWFSLSGLQAEA 293 Query: 294 STRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNM-----VRGYISDNFG--KK 346 R GFG KKT+ +AQ+LY G+I+Y RTDS ++ D + R SD + + Sbjct: 294 GKRFGFGAKKTLDIAQKLYTKGWISYPRTDSGFVTPDEATLFPQTKARLLKSDAYAGLRD 353 Query: 347 YLPESPNQYASKENSQEA--HEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMT 404 L E P++ N+++ H AI P++ + + D KLY LI R+F+A Sbjct: 354 LLTEDPSKNRRYVNAKKVSDHYAIIPTEA---CGDVTRLGGDEAKLYDLINRRFLAAFAP 410 Query: 405 PAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 464 A + TT+ + G +A+G ++ G+ +V+ K E LPA+ G+ ++ Sbjct: 411 AAMLEKTTVDLIDGGDLYRAKGTVVVSPGYRQVVEMKSKDVE---LPALTVGEEFKEKKV 467 Query: 465 TPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYASIISTIQDR 507 T+PP R++E +L+ + E G+G +T A+II ++ R Sbjct: 468 EVLSKQTEPPKRYTEGALIMAMKVAGKQLDDEELIHIMKEVEGLGTEATRANIIDGLKKR 527 Query: 508 GYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD-- 565 GYV+++ + G ++ D L ++ L + TA+ E L ++ A ++ Sbjct: 528 GYVQLQKKELVPTDKGRLLIDVLGDSI--LASPVMTAKWEKRLHEIGQASASAAEFIEQA 585 Query: 566 -----HFFSDFTQQLDKAEKDPE-----------EGGMRPNQMVLTSIDCPTCGRKMGIR 609 H + +++ A +PE +G RP CP CG+ + Sbjct: 586 KKMSVHLVEEAKSRVEAA--NPEGYTIEAKRYGKKGTTRPKASFGI---CPNCGKGL--- 637 Query: 610 TASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 F+GCSGY +E C+ T++ +VL V Sbjct: 638 -VEHPKFIGCSGY----REGCRFTVS----KQVLGV 664 >UniRef50_D2EGP7 DNA topoisomerase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EGP7_9EURY Length = 703 Score = 172 bits (436), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 153/623 (24%), Positives = 289/623 (46%), Gaps = 58/623 (9%) Query: 87 PGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDD--ARYSRVVFNEITK 144 P E ++ +K+ A+KAD + +ATD D EGE+I + +V+ ++ ++ R VF+ +T Sbjct: 103 PTAEDNIAVIKKFAKKADKVIIATDYDTEGESIGFEAIDVVREENTKSKVYRSVFSSLTT 162 Query: 145 NAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIAR----GLSAGRVQSVA 200 + +AF + N D ++ ARR +D ++G +++ + R LS GRVQ+ Sbjct: 163 KELSEAFKNLQKPNKDLSDSADARREIDLILGAVLTRFISLAAERLGNSFLSIGRVQTPT 222 Query: 201 VRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSL 260 + ++V R+ E +AF PE++W A+ T E LA +++ K F E+T + Sbjct: 223 LAIIVARDSERRAFKPEKYWRFTATIQTKDAEFLA---EYKDGKVF----DEKTAEKLRK 275 Query: 261 LEKARYSVLERED-KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITY 319 + + +V+++ D K P PF T+ ++A+ +GF V M + Q LY GY++Y Sbjct: 276 TKNEKKAVIDKVDMKKRRMPPPKPFNTTAFLRSAAA-IGFSVPNAMRIVQGLYMKGYVSY 334 Query: 320 MRTDS-----TNLSQDAVNMVRGYISDNFGK---KYLPESPNQYASKENSQEAHEAIRPS 371 RTDS T ++ +N +R S ++ K + L + N KE H I P Sbjct: 335 PRTDSEAYPPTLDLKEILNELRN--SSSYSKAVSEILKKPLNPTKGKEAKD--HPPIHP- 389 Query: 372 DVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRF 431 V + E L EA +++ LI R+F+A ++ + ++ + A+G + Sbjct: 390 -VKLPNEKLNPQEA---RIFDLISRRFLATLSDESEEEIISIKLDIKGNEFTAKGSRILV 445 Query: 432 DGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGI 491 GW V + E+ ILP + +G+ L ++++ + FT PP +S+ +++K +E + Sbjct: 446 PGWRSVY--IFSKYEENILPEIKEGEILKVLKIDEIEDFTTPPGNYSQGAILKIMEDLNL 503 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G +T I+ + +R Y+ +R ++ V + +++ E+ + TA +E + Sbjct: 504 GTKATRPEILKKLMERRYISA-SRTLIPSEVAFAVIENMQKVSNEITGAELTATLEKEMK 562 Query: 552 QVANHEAEWKAVLDH---FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGI 608 V + + V++ + L K+ +E + CP G K+ + Sbjct: 563 LVEEGQKKKAEVVNESRDMLRKVLKNLQSKRKEIKELMHKALLQQYIFGTCPKSGGKLKL 622 Query: 609 RTA--STGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 + S F+GCS Y +C + L P++ + + + CPKCG Sbjct: 623 VVSKKSHKRFVGCSDYP-----KCHFGMPL-PQSGYFFI------------SPQSCPKCG 664 Query: 667 TAMDSYLIDPKRKLHVCGNNPTC 689 M + ++ ++ NP C Sbjct: 665 IHMIEWHAKESKRTYIFCVNPAC 687 >UniRef50_Q97ZF5 Topoisomerase n=12 Tax=Sulfolobaceae RepID=RGYR2_SULSO Length = 1166 Score = 171 bits (434), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 169/627 (26%), Positives = 277/627 (44%), Gaps = 97/627 (15%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYV-----------------------VKSSVGHIRDL 37 + L+IVESP KAKTI K V + +S GHI DL Sbjct: 578 ISTGLLIVESPTKAKTIAKMFSRPSVRIRNKVPVYETIIVDGNQIYVLDIVASKGHIVDL 637 Query: 38 PTS--GSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHY---EVLPGKEKV 92 G K D + K P D ++ + + + Y L + Sbjct: 638 TLEDIGYYGIKVEDDGTIK----PYYDLIKKCLDCNKIFSSASDKCPYCGSANLQSAQTT 693 Query: 93 VSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN 152 ++ L++LA D +++A+D D EGE IA+ L + ++ RVV++EITK AI +A Sbjct: 694 INLLRELALSVDKVFIASDPDTEGEKIAYDLASFLSPYNSNVYRVVYHEITKKAILEALR 753 Query: 153 KPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI-ARGLSAGRVQSVAVRLVVEREREI 211 P ++N + V +Q RR DR +G+ +S LL K AGRVQ+ + +V + + Sbjct: 754 NPKKINTNLVMSQIVRRIEDRWIGFTLSNLLKTKFNGHNHGAGRVQTPVLGWIVNKTIKY 813 Query: 212 KAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLER 271 K+ G + + + + K + K + + ++ L+ AR + Sbjct: 814 KS---------------AMGHVVYIDIAGYSIKKYFS-EKRKVEEYINNLQVARIEKIS- 856 Query: 272 EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA 331 E+K S P PF T TL A+ + M +AQ L+EAG ITY RTDST++S Sbjct: 857 EEKILLS-PLPPFTTDTLLIEANMKYKLPANLVMKIAQDLFEAGLITYHRTDSTHISSVG 915 Query: 332 VNMVRGYISDN-FGKKYLPESPNQYASKENSQE-AHEAIRPSDVNVMAESLKDMEADAQK 389 + + + Y+ K+++P S E+S+E AHEAIRP+ + E ++++E + K Sbjct: 916 IEIAKEYLQKQALIKEFVPRSW------ESSEEGAHEAIRPTRAIDVNELIQEIEENPYK 969 Query: 390 -----------LYQLIWRQFVACQMTPAKYDSTTLTVGAG-----DFRLKARGRILRFDG 433 +Y LI+++F+A QM+ A + + G D L + G Sbjct: 970 YSIRFSKLHLLIYDLIFKRFIASQMSHAVGTKSRYLIKLGKDDNVDVELLSNAE----GG 1025 Query: 434 WTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPAR--FSEASLVKELEKRGI 491 + KV P K L + E+ P + TK + S + ++ ++ +GI Sbjct: 1026 FIKVYPV--------------KVYNLPVGEIQPKVNITKGSSEQLLSYSDVISLMKSKGI 1071 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFY--AEKMGEIVTDRLEENFRELMNYDFTAQMENS 549 GRPSTYA I + GY+ R+ Y A G V L F +L++ T+++ Sbjct: 1072 GRPSTYAKTIENLMKHGYIVSSKRKSYLIATNRGISVYQFLSSKFYDLVSESTTSRLMTK 1131 Query: 550 LDQVANHEAEWKAVLDHFFSDFTQQLD 576 LD +A + VL FS+ + ++ Sbjct: 1132 LDDIALSKLNASTVLLEIFSEISTLVN 1158 >UniRef50_A4XJT7 Reverse gyrase n=1 Tax=Caldicellulosiruptor saccharolyticus DSM 8903 RepID=A4XJT7_CALS8 Length = 1121 Score = 171 bits (433), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 163/632 (25%), Positives = 273/632 (43%), Gaps = 131/632 (20%) Query: 5 LVIVESPAKAKTINKYLG----------SDY---------VVKSSVGHIRDLPTSGSAAK 45 L+IVESP KA+TI+++L S Y ++ +S GH+ DL T Sbjct: 562 LMIVESPTKAETISRFLEKASTRRYGRLSVYESVTPDGILLITASKGHVYDLDT------ 615 Query: 46 KSADSTSTKTAKKPKKDERGALVNRMGVDPWHN-----------WEAHYEVLP------- 87 K G ++ P++N + Y P Sbjct: 616 --------------KTGVHGVEISNGNFIPYYNSIKRCTSCGTQFTDEYSSCPKCGSDKI 661 Query: 88 -GKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNA 146 K++++ L+++A + D I +ATD D EGE I+W + + + + R+ +EITK Sbjct: 662 DDKKEILKVLREIAAEVDEILVATDPDVEGEKISWDISQYLKPVNPNLRRIEMHEITKFG 721 Query: 147 IRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI-ARGLSAGRVQSVAVRLVV 205 A + N + V +Q RR DR VG+ +S L K + LSAGRVQS + ++ Sbjct: 722 FESAIKNQRDFNANLVKSQIVRRIEDRWVGFELSSKLQKNFQSYNLSAGRVQSTILGWII 781 Query: 206 EREREI----KAFVPEEF-----WEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQA 256 ERE+E K F F +E + G+ + + V +N+K + Sbjct: 782 EREKEYAKSQKEFTFVRFENGFGFEAEGKI---DGDKVLVDVVEENEKELETI------- 831 Query: 257 AVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY 316 PF T TL AS +L V++ M + Q L+E G+ Sbjct: 832 -------------------------LPFNTPTLLSYASQKLNLSVQEIMEILQFLFEHGF 866 Query: 317 ITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSD---- 372 ITY RTDS +S NM R Y+ + GKK L S+ AHEAIRP Sbjct: 867 ITYHRTDSNRISLTGQNMARLYL-EKIGKKDLF-----VGRSFGSEGAHEAIRPVKPISP 920 Query: 373 ---VNVMAESL-KDMEADAQKLYQLIWRQFVACQMTP--AKYDSTTLTVGAGDFRLKARG 426 + +E L + + A+ K+Y+LI+ +F QM +Y + + Sbjct: 921 LELKELSSERLAQGLTANHIKVYELIFNRFFTSQMKNPLVRYQKLIFRFDKQEIEKEMPI 980 Query: 427 RILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL 486 ++ +GW P +I G+ ++E + T P F++A L+ E+ Sbjct: 981 EVIE-EGWLLFSPI-------QIFSKFESGE-YQIIEKKNYKKHTTP--LFTQAMLIDEM 1029 Query: 487 EKRGIGRPSTYASIISTIQDRGYVRVEN-RRFYAEKMGEIVTDRLEENFRELMNYDFTAQ 545 +++ IGRPSTYA ++ + RGYV + RR + +G V L +++++ +N + T Sbjct: 1030 KQKNIGRPSTYAKMVEILFKRGYVFEDQYRRIRSTALGRKVYSYLAQHYQDYINEETTRD 1089 Query: 546 MENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 +E ++ V E ++++VL + + T+ + + Sbjct: 1090 LERLMEVVEIGEKDYQSVLSSLYEELTKIMQR 1121 >UniRef50_A3DN56 Reverse gyrase n=2 Tax=Archaea RepID=A3DN56_STAMF Length = 1220 Score = 171 bits (432), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 175/612 (28%), Positives = 264/612 (43%), Gaps = 108/612 (17%) Query: 5 LVIVESPAKAKTINKYLGSD--------------YVVKSSVGHIRDLPTSGSAAKKSADS 50 LVIVESP KAKTI ++ G +V S V H+ + T G + D Sbjct: 626 LVIVESPTKAKTIARFFGKPVRRKIGSISVYEIPFVKDSEVIHLNIVATRGHLFDLTTD- 684 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNW-----EAHYEVLPGKE-------------KV 92 P G L+ + P + Y+ G +V Sbjct: 685 --------PSIPNHGVLIENNRISPVYTSIKRCRVCGYQFTYGDRCPRCGSTSFTDSYEV 736 Query: 93 VSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN 152 V+ L++LA++AD +Y+ATD D EGE IA+ + I G R R+ +EIT N A Sbjct: 737 VNVLRKLAQEADEVYIATDPDIEGEKIAYDVYLTIKGFVDRVWRIELHEITLNEFLNALE 796 Query: 153 KPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREI 211 +N+ V A+ RR +DRV+G+ +S LW+K ++ L AGRVQ+ Sbjct: 797 NKRNINLKLVEAEIYRRVLDRVIGFSLSQELWRKYSKNWLGAGRVQT------------- 843 Query: 212 KAFVPEEFWEVDASTTTPSGEAL-ALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY-SVL 269 P W +D S + + +T + F + + + Y +++ Sbjct: 844 ----PVLGWIIDHYNKYVSNKCRKIIYITEREGLKFSICIDLKDRDLYEKMRSVEYVTLV 899 Query: 270 EREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ 329 + + T P P+ T L AS R+G TM +AQ L+E+G ITY RT +S Sbjct: 900 LKNSRIETFNPPPPYTTDELLYDAS-RIGIPSTLTMKIAQELFESGLITYHRTSYHYVSS 958 Query: 330 DAVNMVRGYISD-NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADA- 387 +++ Y+ + N K + P S ++ AHEAIRP V +D+E Sbjct: 959 AGISVASKYLENKNLSKHFHP-------SHWGNKGAHEAIRP----VHPLDREDLEKAVV 1007 Query: 388 --------------QKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRF-- 431 ++Y LI+++F++ QM P K + V + +K + Sbjct: 1008 EGIITPTIPLTWLHYRIYDLIFKRFISSQMNPYKALISEYDVVINNEIVKTLVLPIEVVE 1067 Query: 432 DGWTKVM----PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE 487 +G+ VM KG DRI ++ D T++ TKP SE LVK + Sbjct: 1068 EGFNIVMRPKTYGFLKG-HDRI--DISIKDIKTMIT------STKPLC--SEGGLVKLMR 1116 Query: 488 KRGIGRPSTYASIISTIQDRGYV-RVENRRFYA-EKMGEIVTDRLEENFRELMNYDFTAQ 545 + G+GRPSTY+ IIS I GYV R + R F K G V D L +F EL++ D T Sbjct: 1117 EHGLGRPSTYSKIISNIVRHGYVIRSKKRGFLIPTKTGIEVYDYLSNSFPELVSIDTTRD 1176 Query: 546 MENSLDQVANHE 557 ME +D +A E Sbjct: 1177 MEMRIDLIAKGE 1188 >UniRef50_Q0W2I3 DNA topoisomerase I n=2 Tax=Euryarchaeota RepID=Q0W2I3_UNCMA Length = 767 Score = 169 bits (428), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 155/577 (26%), Positives = 266/577 (46%), Gaps = 43/577 (7%) Query: 81 AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG-DDARYSRVVF 139 A P K+ +V L LA K + +ATD DREGE I +I + RV + Sbjct: 73 AQVVTYPSKKDLVGALATLATKVTRVTIATDYDREGEMIGVEAYNIIKKISSPTFDRVRY 132 Query: 140 NEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS---PLLWKKIARG-LSAGR 195 + TK I +AF P ++ D A + R+ +D V G ++ + K + LS GR Sbjct: 133 SSFTKEEITKAFASPTAVDFDLAAAGECRQEIDLVWGAALTRFVSIAGNKFGKDFLSVGR 192 Query: 196 VQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQ 255 VQ+ + L+V+RE+EI+AF + +WE+ A+ E + +H+ + +K++ Sbjct: 193 VQTPLLALIVDREKEIQAFTSKPYWEIVATLLK---EDRSFTASHKRGR----FDKKEEA 245 Query: 256 AAVSLLEKARYSVLEREDKPTTSK--PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE 313 AA+ +K + + ++ K K P PF T+ +AAS LGF M +A+ LY Sbjct: 246 AAIH--KKLGKTAVVKDVKADRKKEQPPIPFNTTEFVKAASA-LGFTAASAMQIAEALYI 302 Query: 314 AGYITYMRTDSTNLSQDAVNM--VRGYI--SDNFGKKYLP--ESPNQYASKENSQ-EAHE 366 G+I+Y RTD+T + D +N+ + G S +F K L P+ ++ + + H Sbjct: 303 NGWISYPRTDNT-VYPDTLNLKDLLGIFKTSPDFAKSALELLAMPSITPTRGKVETKDHP 361 Query: 367 AIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARG 426 I P V KD++ KLY+L+ R++ A ++++ + A G Sbjct: 362 PIYP----VACAMRKDLDDRQWKLYELVVRRYFATLSPACEWETIKAEIDISGEPFAANG 417 Query: 427 RILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL 486 + L GW K P + DE +LP + GD L + + + T+PP R+ + LV+ + Sbjct: 418 KQLAVPGWRKHYPYGLQKDE--LLPPLKAGDPLLVRKADLLEKKTEPPKRYGQGKLVQMM 475 Query: 487 EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546 E G+G +T ++ + RG+ +E G + D L+ + + T+++ Sbjct: 476 EDLGLGTKATRHEALAKLYQRGF--IEGNPPQPTATGISLIDALKAYASAITSNAMTSKL 533 Query: 547 ENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG--MRPNQMVLTSID-CPTCG 603 E +D +A + + AV + D+ EK+ E G +R + I CP CG Sbjct: 534 ERDMDAIAASQLKKAAVAKESREMLDKVFDQLEKNRLEIGRILRSGFAADSDIGPCPLCG 593 Query: 604 RKMGI--RTASTGVFLGCSGYALPPKERCKTTINLVP 638 + + R + F+ CSG+ C+ T N+ P Sbjct: 594 SALVVRERKSDKNKFIACSGF-----PNCRNTYNVPP 625 >UniRef50_Q8ZXT5 Topoisomerase n=5 Tax=Thermoproteaceae RepID=RGYR_PYRAE Length = 1228 Score = 169 bits (428), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 165/638 (25%), Positives = 273/638 (42%), Gaps = 111/638 (17%) Query: 1 MGKALVIVESPAKAKTINKYLG-------------------SDYVVKSSVGHIRDLPTSG 41 M L++VESP KA+TI + G + +V +S+GHI +LPTS Sbjct: 633 MRTILMVVESPTKARTIANFFGRPSLIISEGIPIYEVSTGDAVLMVTASLGHIYELPTSL 692 Query: 42 SAAKKSADSTSTKTAKKPKK-----DERGALVNRMGVDPWHN--WEAH-------YEVLP 87 + + K K + +V G P +N W ++ P Sbjct: 693 NKIDQRQREVLAKWFGDFKHGNYDGENYAVIVKEYGFVPVYNKIWRCRGAVYVDDIDIPP 752 Query: 88 GKE--KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKN 145 G + V+ ++ +A + D + L TD D EGE IA+ L + RV F+E+T+ Sbjct: 753 GCKPLDVLEAIRNIAVEVDTVLLGTDPDSEGEKIAFDLYLGLRPYVQDIRRVEFHEVTRR 812 Query: 146 AIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIAR-GLSAGRVQSVAVRLV 204 AI A P +N V AQ RR DR +G+ +S +L LSAGRVQ+ + + Sbjct: 813 AILNALANPRGVNFSLVKAQIVRRVEDRWIGFGLSKILQANFKNPNLSAGRVQTPVLGWI 872 Query: 205 VEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKA 264 V E + + V+ + + Q + V +++ + A+ L+ + Sbjct: 873 VNTYEE---SLKNRVYNVELQLND-------VDIRLQVPRDVLDVLRKKKRVAIKLVARE 922 Query: 265 RYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDS 324 R V P P+ T L + A +LG M +AQ L+E+G ITY RTDS Sbjct: 923 RRQV----------NPPPPYTTDELLRDAVNKLGLSADYAMRLAQDLFESGLITYHRTDS 972 Query: 325 TNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPS------------D 372 T +S + + R YI FG+ P + E AHEAIRP+ + Sbjct: 973 TRVSTAGIAIAREYIVRKFGEGVF--KPRSWGEAEEG--AHEAIRPTRPIDVEELRGLVN 1028 Query: 373 VNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFD 432 V+ +++ ++ Q LY +I+R+F+A QM P+ V + ++ G +++ Sbjct: 1029 AGVIQLAIQLTKSHYQ-LYDIIFRRFMASQMEPS-------VVEVAKYNVEIDGHVIQL- 1079 Query: 433 GWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQ-------------HFTKPPARFSE 479 +R + G TL +LTP + + S+ Sbjct: 1080 --------------ERTVGVAYMGFQ-TLYQLTPVEPELPTGTLDVVIKRYRVVRRVLSQ 1124 Query: 480 ASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR--FYAEKMGEIVTDRLEENFREL 537 A ++ + +RGIGRPSTYA I+ + R YV V R K G + L+E F +L Sbjct: 1125 ADVLALMRQRGIGRPSTYAHILQVLAKRYYVYVTGRTKLMIPTKRGREIFRFLKEAFGKL 1184 Query: 538 MNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 ++ D T +E +D + +A ++ V+ + +F +++ Sbjct: 1185 VSEDRTRLIEQYMDAIEVGKARYEEVIAELYDEFRKEV 1222 >UniRef50_C7DGI7 DNA topoisomerase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DGI7_9EURY Length = 727 Score = 166 bits (420), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 159/573 (27%), Positives = 255/573 (44%), Gaps = 59/573 (10%) Query: 96 LKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDAR-----YSRVVFNEITKNAIRQA 150 LK+LA++ A D D EG I ++ + + G A R+ F+ T + + Sbjct: 93 LKKLAQECSTFINACDYDIEGTVIGTNIIKELSGLQAEAIGSVSKRMKFSTTTPKDLLDS 152 Query: 151 FNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-----RGLSAGRVQSVAVRLVV 205 F +I+ A +AR +D + G S L ++ + LS GRVQ A+ L+ Sbjct: 153 FGSLLPPDINNFYAGEARHMLDWLWGINFSRALTSALSSSGQYKQLSIGRVQGPALGLLA 212 Query: 206 EREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKAR 265 +RE+EI +F PE +W V A SGE + + F K++ ++A S R Sbjct: 213 KREKEIASFKPEPYWNVLAY----SGE---FEFINSRGNIFA---KQEAESAFSAANSGR 262 Query: 266 YS--VLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTD 323 + V E +P PF ++LQ AS GF T+ MAQ LYE +I+Y RT Sbjct: 263 DNAVVSEATSAEQLRRPYPPFDLTSLQLEASRVFGFDPSATLAMAQSLYERSFISYPRTS 322 Query: 324 STNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK--------ENSQEAHEAIRPSDVNV 375 S L + + + R I+D + ASK EAH AI P+ V Sbjct: 323 SQKLPR-TLGLPR-IIADLGKNPAYSTIAAEIASKGRFTPAEGPKEDEAHPAIFPTGV-- 378 Query: 376 MAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWT 435 + K + +KLY LI R+F++C AK ++ +L + G + +G + + GW Sbjct: 379 ---TPKGITGSEEKLYDLIARRFLSCFGEYAKVNNFSLEISIGGETFEGKGSKVTYPGWL 435 Query: 436 KVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPS 495 + + D LP + KG + + ++ + T PP RF++A L+ ELEK +G + Sbjct: 436 DYYKYAKIKERD--LPNLEKGQRVEITDIKMPELQTAPPKRFTKAGLISELEKHNLGTKA 493 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 T A+II T+ R Y +E + G V D LE+N +++ D T +E +D ++ Sbjct: 494 TRAAIIDTLFKRNY--IEGSSIRVTEFGMTVYDALEKNCSMIVDEDTTITLEKDMDLISK 551 Query: 556 HEA-------EWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGI 608 + + K VL F +K ++ +E N + CP G + I Sbjct: 552 GKMPESEVLKKGKEVLLTAIETFNSNKEKISEEMKESFKSANVLG----KCPKDGGDLVI 607 Query: 609 RTASTG-VFLGCSGYALPPKERCKTTINLVPEN 640 + + G F+ CS Y +C T L P+N Sbjct: 608 KRSFRGKQFVACSNYP-----KCTNTYPL-PQN 634 >UniRef50_A8A9U6 Reverse gyrase n=3 Tax=Archaea RepID=A8A9U6_IGNH4 Length = 1259 Score = 164 bits (414), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 159/575 (27%), Positives = 254/575 (44%), Gaps = 104/575 (18%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYV-------------------VKSSVGHIRDLPTSG 41 M L+IVESP KA+TI + G V V +S GH+ DL Sbjct: 620 MKTVLMIVESPNKARTITSFFGRPSVRQVKGVKVYEVTLGDKLLYVAASGGHVYDLVEEA 679 Query: 42 SAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLP--------GKEKVV 93 + K +E + + R V H + + P + VV Sbjct: 680 DPCNEEP-CMLFGIRVKDVPEEVLSSIKRCAV-CGHQFSGDVKECPRCGSPFIKDAKDVV 737 Query: 94 SELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK 153 L++LA++ D + + TD D EGE I W L+ +I + R F+EITK AI +A Sbjct: 738 DGLRELAQEVDEVLIGTDPDTEGEKIGWDLKNLISPFAKKIRRAEFHEITKKAILKALEN 797 Query: 154 PGELNIDRVNAQQARRFMDRVVGYMVSPLLW---------------KKI-----ARGLSA 193 P + ++ V +Q RR DR+ G+ +SP LW KK+ R LSA Sbjct: 798 PRDFDMGYVWSQMVRRAEDRLTGFTLSPKLWFELWPQLCEVSKEMKKKLLGCPLTRNLSA 857 Query: 194 GRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQ 253 GRVQ+ + V++R EE+ + + L+ + + F Sbjct: 858 GRVQTPVLGWVIQRY--------EEYAKSKKKFYIIRFDGRELEFSEDELRGF------- 902 Query: 254 TQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE 313 + L + +L+ E++ KP P+ T T+ + AS +LG + M +AQ L+E Sbjct: 903 ---SKKLAIDGKVKILKVEEEVEELKPLPPYTTDTMLEDAS-KLGLDPSRAMRVAQDLFE 958 Query: 314 AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDV 373 G+ITY RTDST +S + + R +I+ F + P + AHEAIRP+ Sbjct: 959 MGFITYHRTDSTRVSDAGIAVAREWITSKFEGLFAPRRWGEGG-------AHEAIRPTR- 1010 Query: 374 NVMAESLKDM----------EADAQK--LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFR 421 + AE LK + E Q LY +I+R+F+A QM AK + + Sbjct: 1011 PLSAEDLKRLIEEGMITPPRELSKQHFMLYDMIFRRFMASQMKEAKVKKAVYEITVEEGG 1070 Query: 422 LKARGRILR------FDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPA 475 ++L FDG+ V P ++ + ++ +G+ + E+ T P Sbjct: 1071 AVVGKKVLEKYVERVFDGFLLVYPIVK-------IESLPEGE-YEVKEVRAVSRHTVP-- 1120 Query: 476 RFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 +++A L++ +++RG+GRPSTYA I+ST+ +R YV Sbjct: 1121 LYTQADLIRLMKERGLGRPSTYAKIVSTLLERRYV 1155 >UniRef50_C9RG81 DNA topoisomerase I n=2 Tax=Methanocaldococcus RepID=C9RG81_METVM Length = 928 Score = 164 bits (414), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 161/602 (26%), Positives = 274/602 (45%), Gaps = 95/602 (15%) Query: 4 ALVIVESPAKAKTINKYLGS-------------------DYVVKSSVGHIRDLPTSGSAA 44 AL+I E P+ AK I LG +V S+VGH+ L Sbjct: 3 ALIICEKPSVAKKIANALGKPKKKSIDGVPYYELERDGKKIIVASAVGHLFTL------- 55 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKE---KVVSELKQLAE 101 ++ + + K P D + W V GKE K + LK+L++ Sbjct: 56 ---VENENNEFGKYPIFDIK--------------W-VPASVDKGKEYVNKYIKALKKLSK 97 Query: 102 KADHIYLATDLDREGEAIAWH-LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNID 160 +AD Y+ATD D EGE I +H L+ G + A+ R+ F+ +TK I +AF P E++ Sbjct: 98 EADEFYIATDWDIEGELIGYHALKYCCGREKAK--RMRFSSLTKKEIVKAFENPDEIDYG 155 Query: 161 RVNAQQARRFMDRVVGYMVSPLLWKKIA-----RGLSAGRVQSVAVRLVVEREREIKAFV 215 V+A ++R +D G +S L I + +S GRVQ A+ + ERE EIK F+ Sbjct: 156 LVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFI 215 Query: 216 PEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 P+ +W ++A L+ H+ +K + KE + ++ V+E + Sbjct: 216 PKPYWVIEALLKD------NLKAIHEKEKFWD--EKEAKSVYEKIKDEKSAKVVEIKKTK 267 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLS------Q 329 KP PF TLQ+ A + K+T +AQRLYE I+Y R+ S L + Sbjct: 268 RRIKPLPPFDLGTLQREAYSYFKISPKETQEIAQRLYERALISYPRSSSQKLPKDRKYLE 327 Query: 330 DAVNMVRGY-ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ 388 D +N+++ + I + +K L ++ K++ AH AI D+ S + Sbjct: 328 DILNIIKNHPIYGKWAEKILEKNLKPVEGKKDDP-AHPAIHIVDIPKEELS-----EKEK 381 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR 448 K+Y LI R+ ++ A+ + + + + K G +GW ++ K DE Sbjct: 382 KIYDLIARRTLSAFWDNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIY-YFPKFDEIE 440 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508 LP + K D + + ++T + T+PP R++ AS++KELEKRG+G A + Sbjct: 441 -LPPLKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKRGLGTKCLTAKTLIK----- 494 Query: 509 YVRVENRRFY--AEKMGEIVTDRLEENFREL---------MNYDFTAQMENSLDQVANHE 557 V+++N Y EK+ E++ ++ +E EL ++++ ++E+S ++ + Sbjct: 495 -VKIDNEIKYMEIEKLFELLNEKYKEKNIELAVNNKDIKCFSFNYKDEVESSFKFISRRK 553 Query: 558 AE 559 E Sbjct: 554 LE 555 Score = 73.9 bits (180), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 73/274 (26%), Positives = 117/274 (42%), Gaps = 40/274 (14%) Query: 495 STYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 ST A II + RGYV V++ +G V + L+ E+++ T +E L+++ Sbjct: 648 STRAEIIDKLIKRGYV-VDDGSLKVTDLGISVIETLKRFCPEIVDEKMTRDLEEKLEKIQ 706 Query: 555 NHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR-------PNQMVLTSIDCPTCGRKMG 607 + + VLD + + L++ ++ E+ G N+ CP CG + Sbjct: 707 FRKIKKDEVLDEAENKLRKILEEFKEKEEDVGTYLIKNLDATNKKAKIVGKCPKCGGDLI 766 Query: 608 IRTASTGVFLGCSGY-------ALPPKER----------CKTTINLVPENEVLNVLEGED 650 + F+GCS Y +LP K R CK+ I + + E+ E Sbjct: 767 LIRHKKSRFVGCSNYPECDVNYSLPDKGRIKIPNKVCNACKSPILKIGDREICINPECPL 826 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKR---KLHVCGNNPTCDGYE-IEEGEFRIKGYDG 706 + R CPKCG LI K + C N P C E I + E I G Sbjct: 827 KQVEIKEEDRICPKCGAE----LILKKGVYGAFYGCSNYPKCKYTEPINKKEKEIVG--- 879 Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTN-EECKNT 739 +C KCG ++ ++ G+FGK++ C+N +CK T Sbjct: 880 ---KCPKCGGDLVVREGKFGKFIGCSNYPKCKYT 910 Score = 47.4 bits (111), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/151 (27%), Positives = 61/151 (40%), Gaps = 27/151 (17%) Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHV-CGNNPTCD-GYEI-EEGEFRI 701 +++ DA + +CPKCG D LI K+ V C N P CD Y + ++G +I Sbjct: 741 LIKNLDATNKKAKIVGKCPKCGG--DLILIRHKKSRFVGCSNYPECDVNYSLPDKGRIKI 798 Query: 702 KGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPEL 761 P C C S + + G C N EC P K+ + + Sbjct: 799 -----PNKVCNACKSPIL----KIGDREICINPEC-------------PLKQVEIKEEDR 836 Query: 762 PCEKSDAYFVLRDGAAGVFLAANTFPKSRET 792 C K A +L+ G G F + +PK + T Sbjct: 837 ICPKCGAELILKKGVYGAFYGCSNYPKCKYT 867 >UniRef50_A8A9J9 Reverse gyrase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A9J9_IGNH4 Length = 1087 Score = 163 bits (413), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 144/475 (30%), Positives = 231/475 (48%), Gaps = 56/475 (11%) Query: 91 KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQA 150 KVV L++LA D +YLATD D EGE IAW + +I ++ R+ + E+T + +A Sbjct: 630 KVVEALRRLATVVDEVYLATDPDEEGEKIAWDVMAMIYPFNSNIKRMKYYEVTLRGLHEA 689 Query: 151 FNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG---LSAGRVQSVAVRLVVER 207 + ++ V +Q RR DR+VG+ VS L K A G GRVQ ++ VVER Sbjct: 690 LSFLTTVDEGTVRSQIVRRLDDRLVGFAVSERL--KAAFGDPNHGLGRVQGPVLKFVVER 747 Query: 208 EREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYS 267 + KA +G ++ L +++ + KE+ A+ L Sbjct: 748 AKARKA---------------SAGYSVTLHLSNGDTLRLFVKTKEE---ALKLASVEEVK 789 Query: 268 VLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNL 327 +L+ E++ KP P+ T T+ + AS +LG + M +AQ L+E G+ITY RTDST + Sbjct: 790 ILKVEEEVEELKPLPPYTTDTMLEDAS-KLGLDPSRAMRVAQDLFEMGFITYHRTDSTRV 848 Query: 328 SQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK------ 381 S + + R +I+ F + P + AHEAIRP+ + AE LK Sbjct: 849 SDAGIAVAREWITSKFEGLFAPR-------RWGEGGAHEAIRPTR-PLSAEDLKLDFALN 900 Query: 382 DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKAR--GRILRFDGWTKVMP 439 M +A +LY +I+R+F+A QM AK + R+++ IL GWT V Sbjct: 901 GMSFEALRLYDMIFRRFMASQMKEAKVRKVKVVYEVAGKRVESAWVAEILE-PGWTSVWN 959 Query: 440 ALRKGDEDRILPAVNKGDA--LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTY 497 K + + V + +LV+L P F +++ +++RG+GRPSTY Sbjct: 960 IKTKDIKLEKVAKVVSSEVRRASLVQL---------PKVF---EVIRWMKERGVGRPSTY 1007 Query: 498 ASIISTIQDRGYVRVE-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 A + ++ GYV + N + K G V + +E NF EL ++T ++E +++ Sbjct: 1008 AKTVENLRRHGYVVITPNNYVVSTKKGVAVAEYVERNFPELAEAEYTRRLEEAME 1062 >UniRef50_A8MCZ0 Reverse gyrase n=5 Tax=cellular organisms RepID=A8MCZ0_CALMQ Length = 1284 Score = 162 bits (411), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 177/676 (26%), Positives = 282/676 (41%), Gaps = 137/676 (20%) Query: 1 MGKALVIVESPAKAKTINKYLG--SDYVVKSSV-----------------GHIRDLPTSG 41 + LVIVESP KA+TI + G S V+ S + GH+ +L T Sbjct: 630 LKSVLVIVESPTKARTIANFFGKPSTRVLGSLIVYEVTSGNLLLNIIATKGHVVELATEQ 689 Query: 42 SAAKKSAD--------STSTKTAKKPKKDE-----------RGALVNRMGVDPWHNWEAH 82 A S+D S+ T+ K + R R D Sbjct: 690 YAQSVSSDVDYVTKFISSVTRNYYSVLKIDGNFIPIYSTIKRCPTCGRSFTDDVSKCPFD 749 Query: 83 YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEI 142 L V+ L+ LA + D + + TD D EGE IAW + ++ R+ F+E+ Sbjct: 750 GTPLVDSSGVIEMLRDLATEVDLVLVGTDPDSEGEKIAWDVFNMLRPFVQDIRRIEFHEV 809 Query: 143 TKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAV 201 TK AI A P +N + V AQ RR DR +G+ +S L + R +SAGRVQ+ + Sbjct: 810 TKRAILNALANPRGVNGNMVKAQLVRRIEDRWIGFGLSSYLQRAFNDRNMSAGRVQTPVL 869 Query: 202 RLVVE------REREIKAFVPEEF-----WEVDASTTTPSGEALALQVTHQNDKPFRPVN 250 + ++E R R I+ V + EV T E +V H R V Sbjct: 870 KWIIERYIEYRRNRVIRLIVRKRISDGKVLEVSFDKVTNGDE--TARVRHD----LRDVA 923 Query: 251 KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQR 310 K++ + R + + + P PF T ++ A+ RL G ++ M +AQ Sbjct: 924 KDK--------KGLRIIITKLSESEEEVNPPPPFTTDSMLTEATARLRAGTEEVMRLAQE 975 Query: 311 LYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRP 370 L+E G ITY RTDST +S +++ + Y+++ FG+ + ++ E + AHE IRP Sbjct: 976 LFEMGLITYHRTDSTRVSAVGISVAKEYLTNRFGEGVF--TAREWGMGE--EGAHECIRP 1031 Query: 371 S------------DVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPA---KYDSTTLTV 415 + D V+ L + LY LI+R+F+A QM K + Sbjct: 1032 TRPIDSEELRSLIDSGVLKLKLTNRHI---ALYDLIFRRFMASQMQSGLVKKVKVEVKLM 1088 Query: 416 GAGDFRLKAR-----GRILRFDGWTKVMPALRKG---DEDRILPAVNKGDALTLVELTPA 467 GD L +R ++R +G+ + P +R + LP + + + Sbjct: 1089 RNGDM-LSSRVDEFVTSVIR-NGFLAIYPTIRVTQFPESSMELPVTEEDEV-----IVKT 1141 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR---------------- 511 H T P + E +V E+++R IGRPSTYA II T++ RGYV+ Sbjct: 1142 VHTTYP---YREGDIVAEMKRRRIGRPSTYAKIIETLKRRGYVKALGSTKVLIPTKRGVA 1198 Query: 512 ---------------VENRRFYAEKMGEI--VTDRLEENFRELMNYDFTAQMENSLDQVA 554 + RR ++ E + + NF+ L++ D T +E +D + Sbjct: 1199 AYICLSNDKDVAKLYLSTRRNKVQENTEFESLLKQCNVNFKCLISEDRTRMVEEHMDNIE 1258 Query: 555 NHEAEWKAVLDHFFSD 570 N + ++ VL F++ Sbjct: 1259 NGDEDYLTVLHELFNE 1274 >UniRef50_B2UU25 Topoisomerase I n=6 Tax=Helicobacter pylori RepID=B2UU25_HELPS Length = 644 Score = 162 bits (411), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 134/482 (27%), Positives = 232/482 (48%), Gaps = 40/482 (8%) Query: 106 IYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP---GELNIDRV 162 +Y+ATD DREG I + E I R F+EITK+ + + N + N++ Sbjct: 78 VYIATDPDREGYGIGYKFYEKIKNIAKTIYRTEFHEITKSGVEKGLNNAVLFSQSNLNLY 137 Query: 163 NAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREIKAF----VPE 217 + R D+ VG+ ++P L K I +SAGRVQ+ A+ ++VE +R+I+AF + E Sbjct: 138 YSWLGRIVSDQFVGFTLTPYLRKNIKNFEVSAGRVQTTALSILVELDRKIQAFEQKNIDE 197 Query: 218 EFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEK-----ARYSVLERE 272 + + G +++ + +N + KE Q ++ L+ A +E++ Sbjct: 198 KLSYSIEAIIDVLGSQISITLVEENKRKVFET-KELAQNFLNDLKNNLNPLAFLDAVEQK 256 Query: 273 DKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV 332 DK + P PF TS L + L GVK+ AQ+L+EAG ITY+RTDS LS++ + Sbjct: 257 DKEKS--PPKPFTTSNLLKDGVRILEMGVKQIQEHAQKLFEAGLITYIRTDSEALSKEYL 314 Query: 333 NMVRGYISDNFGKKYLPESPNQYASKENSQ-EAHEAIRPS------DVNVMAESLKDMEA 385 + + + + Y +Y + +NSQ EAHEAIR + D+ + E + Sbjct: 315 QEHQAFFENIYPSVY---EYREYRAGKNSQAEAHEAIRITHPHCYEDLKKVCEKHNITDI 371 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD 445 + K+Y LI+ + Q A Y++TTL K L+ G+ + + Sbjct: 372 NDLKVYTLIFFNTICSQSKNAIYENTTLNFKVKTHSFKCSFSKLKSKGFKAIKDLEEEKK 431 Query: 446 EDRILPAVNKGDALTLVELTPAQHF------TKPPARFSEASLVKELEKRGIGRPSTYAS 499 ++ + + +L L P F TK P+ ++E++ + +E GIGRPSTY S Sbjct: 432 DEEEIESDLDFSSLQLKTQMPILDFNIKELKTKAPSPYTESTFIAMMETYGIGRPSTYTS 491 Query: 500 IISTIQDRGYVRVE--NRRFYAEKMGEIVTD-RLEENFRELM-----NYDFTAQMENSLD 551 + ++++ Y+ +E NR+ +G+ + D L +N + + + FT ++E LD Sbjct: 492 VFEILKNKNYITLEGKNRKITPTALGKSIVDFFLNDNQTQWIAISKVDNSFTKKLEEMLD 551 Query: 552 QV 553 + Sbjct: 552 MI 553 >UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3_BACAH Length = 729 Score = 162 bits (410), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 174/669 (26%), Positives = 292/669 (43%), Gaps = 85/669 (12%) Query: 1 MGKALVIVESPAKAKTI----------NKYL-GSDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M K++VI E P+ A+ I N YL GS Y+V ++GH+ L AD Sbjct: 1 MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTL----------AD 50 Query: 50 STSTKTA-KKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYL 108 S KK ++ L R+ + + V S+L L + + I + Sbjct: 51 PESYDVKYKKWNLEDLPMLPERLKLTVIKQTGKQFNA------VKSQL--LRKDVNEIIV 102 Query: 109 ATDLDREGEAIA-WHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQ 165 ATD REGE +A W + +V + R+ + +T AI+ F KPG+ + + Sbjct: 103 ATDAGREGELVARWIIDKVRINKPIK--RLWISSVTDKAIKDGFANLKPGKAYDNLYASA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D +G + L + L+ GRVQ+ V ++ RE EIK F + ++ ++A Sbjct: 161 VARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQ 220 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 TT L Q + N + F NKE+ V L+K +VLE + K S + Sbjct: 221 TTNQL--KLTWQDANGNSRSF---NKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLYD 275 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTNLSQDAVNMVRGYISDNFG 344 + LQ+ A+ + G+ K+T+ + Q+LYE +TY RTDS +S D V + + Sbjct: 276 LTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGV 335 Query: 345 KKYLP------ESP---NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 +Y P + P N+ ++ H AI P++ V + D E +K+Y L+ Sbjct: 336 GEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYVNFSAFTDKE---RKIYDLVV 392 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE------DRI 449 ++F+A +Y+ TL G+ ARG+ + GW +V + D+ +++ Sbjct: 393 KRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQL 452 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK-------------------RG 490 LP + KGD LT+ + TK PARF+EA+L+ +E G Sbjct: 453 LPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTGG 512 Query: 491 IGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSL 550 +G +T A II + + + + + G + D + E EL + T + E L Sbjct: 513 LGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPE---ELKSPTLTGEWEQKL 569 Query: 551 DQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRT 610 + +A + + K V ++T+++ K ++ N +++ CP CG+ M Sbjct: 570 EAIAKGKLK-KEVFISEMKNYTKEIVSEIKSSDKKYKHDN---ISTKSCPDCGKPMLEVN 625 Query: 611 ASTGVFLGC 619 G L C Sbjct: 626 GKKGKMLVC 634 >UniRef50_A8U720 DNA topoisomerase n=3 Tax=Lactobacillales RepID=A8U720_9LACT Length = 713 Score = 162 bits (410), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 161/609 (26%), Positives = 269/609 (44%), Gaps = 77/609 (12%) Query: 74 DPWHNWEAH----------YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 D W W ++V GK K + +K+L ++AD I +ATD DREGE IA + Sbjct: 57 DEWKKWNMKELPIIPQTFKFKVGQGKSKQFNIIKRLLKEADQIVIATDSDREGENIARSI 116 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFMDRVVGYMVS- 180 D+ R+ N + + I++ F+ + G+ Q R+ D +VG +S Sbjct: 117 ISQAKADNKEIKRLWINSLEADEIQKGFSDLRDGKDFYSAYIEAQTRQISDWLVGINLSR 176 Query: 181 ----PLLWKKIARGL-SAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALA 235 L K I G+ S GRVQ+ + ++ R++EI+ F+PE F+E+ A+ G A Sbjct: 177 MYTLSLQKKGINEGVFSVGRVQTPTLYMIYTRQKEIENFIPEPFFEMHATIKAEKGSFKA 236 Query: 236 LQVTHQNDKPFRPVNKE-QTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI--TSTLQQA 292 + +K F P KE Q L + V+ S+P +PF+ S LQ Sbjct: 237 -----KYNKKF-PTKKELQDLIKKHELLASNPGVISDIGTKRISQP-SPFLFSLSDLQSL 289 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD----AVNMVRGYISDNFGKKYL 348 + + T+ Q LYEA ++Y R+D +++ + + GY S Y Sbjct: 290 INKKYKVSPSDTLKHVQSLYEAKLLSYPRSDCRHITDSEFHYLIERIDGYQS---VLNYT 346 Query: 349 PESPN-----QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQM 403 E PN +Y QE H AI P+ + L + + +++Y + ++ +A Sbjct: 347 IEQPNTSKRKRYVDGSKVQE-HYAIIPTKKVPTQKELDKLTSIQKEIYYTVLKRTMAMFE 405 Query: 404 TPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRK---GDEDRILPAVNKGDALT 460 T KYD TT+TV ++GR + GW K+ A K +E+ LP V K +A+ Sbjct: 406 TDYKYDETTITVEIKKLPFISKGRTILDKGWRKLEYAASKKTDKEENTELPLVQKNEAIE 465 Query: 461 LVELTPAQHFTKPPARFSEASLV-------KELEK----------RGIGRPSTYASIIST 503 +L ++ FT PP ++E +L+ KELE GIG +T A+++ T Sbjct: 466 -ADLATSEGFTAPPKSYTEGTLITAMKTCGKELENVEEKEILKATEGIGTEATRANVLET 524 Query: 504 IQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 ++ + Y+ ++ + G I+ ++ L + + TA+ E L ++ E +A Sbjct: 525 LKKQHYIEIQKNDVTVTQKGAILCQAVKNTL--LSSPEMTAKWETYLKKIKKEEGTQEAF 582 Query: 564 L-------DHFFSDFTQQLDKAEKDPEEGGMRP--NQMVLTSIDCPTCGRKMGIRTASTG 614 L DH + Q ++ ++ M +Q T CP CG+ + G Sbjct: 583 LENIQKFIDHTLASSAQVIESSDWSTRITSMNQTISQTKQTIGTCPACGQSI----IDKG 638 Query: 615 VFLGCSGYA 623 F GCSGY+ Sbjct: 639 KFYGCSGYS 647 >UniRef50_Q08582 Topoisomerase n=11 Tax=Sulfolobus RepID=RGYR_SULAC Length = 1248 Score = 161 bits (408), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 167/655 (25%), Positives = 284/655 (43%), Gaps = 119/655 (18%) Query: 4 ALVIVESPAKAKTINKY------------------LGSDYV-VKSSVGHIRDLPTSG--- 41 L++VESP KAKTI+ + LG + V +S GH+ DL T Sbjct: 626 VLLVVESPNKAKTISSFFSRPSIRQIGNMRVYETVLGDKVLMVTASGGHVYDLTTQDMGI 685 Query: 42 ---SAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHN--------WEAHYEVLPGKE 90 K+++ KK E N D + + + Y+ L Sbjct: 686 YGVDIMKQNSSLVFIPIYNSIKKCEN----NHQFTDFFESNKCPRCMTTKVRYDSL---- 737 Query: 91 KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQA 150 K ++ L+ LA +AD + + TD D EGE IAW L + ++ R F+E+T+ AI QA Sbjct: 738 KSINVLRNLAVEADEVLIGTDPDTEGEKIAWDLYLALRPYNSNIRRAEFHEVTRKAILQA 797 Query: 151 FNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI------------------ARGLS 192 N+P E N++ V +Q RR DR +G+ +S +L + + LS Sbjct: 798 INQPREFNVNLVKSQLVRRIEDRWIGFKLSSILQTRFWPEYCKSLSSNKQLNCNENKNLS 857 Query: 193 AGRVQSVAVRLVVEREREIKAFVPEEFW-EVDASTTTPSGEALALQVTHQNDKPFRPVNK 251 AGRVQ+ + +V+R E + ++ ++D + + + V Q+ + Sbjct: 858 AGRVQTPVLSWIVDRYTEYQRNKSRVYYGKIDQL------QDIVIYVPKQDGV------R 905 Query: 252 EQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRL 311 + ++ V E + LE E P P+ T TL ++ G +TM +AQ L Sbjct: 906 KNSKIVVVFNEINQ---LEEEFGPL-----PPYTTDTLLSDSNNFFGLSAPETMRIAQDL 957 Query: 312 YEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE-NSQEAHEAIRP 370 +E G ITY RTDS +S +++ Y+ D G KY N + + AHE IRP Sbjct: 958 FELGLITYHRTDSNRISNTGISVAENYLKDVLGDKY----TNIFKPRSWGDGGAHEGIRP 1013 Query: 371 S---DVN--------VMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD 419 + DV E K + + K+Y +I+R+F++ Q+ P K + + Sbjct: 1014 TKPIDVEQLRLLIEEGELELAKRLTNNHFKVYDIIFRRFISSQIIPLKVRKEIVKIEL-- 1071 Query: 420 FRLKARGRILRFDGWTKVMPALR-KGDEDRI-----LPAVNKGDAL------------TL 461 + + +I +V+ + G + I +P N ++ T Sbjct: 1072 YGENKKEKINSNQNIIEVITGITLPGIDTEISKFAYVPVRNVSRSVAERLKELGRSIPTD 1131 Query: 462 VELTPAQHFTKPPAR-FSEASLVKELEKRGIGRPSTYASIISTIQDRGYV--RVENRRFY 518 + + F K +++A LV E++ + IGRPSTYA+II TI RGYV ++ ++ Sbjct: 1132 FSIEISNSFIKSTVNLYTQADLVMEMKNKKIGRPSTYATIIGTILRRGYVLESLKTKKLI 1191 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ 573 ++G V L EN+ ++ D T ++ +D V + +++ VL + + + Sbjct: 1192 PTRLGVEVNKYLNENYGRFVSEDRTRKLLQLMDMVEAGQEKYEEVLKQVYEEINE 1246 >UniRef50_B5IDE0 Reverse gyrase n=3 Tax=Archaea RepID=B5IDE0_9EURY Length = 1030 Score = 160 bits (406), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 154/613 (25%), Positives = 272/613 (44%), Gaps = 117/613 (19%) Query: 4 ALVIVESPAKAKTINKYLG-----------------SDYV--VKSSVGHIRDLPTSGSAA 44 +L IVESP KAK I + G D V + S+GH DL T+ Sbjct: 484 SLFIVESPNKAKHIAHFFGKPNLRIIGNAVVYEVAVGDRVLTIAPSLGHTVDLSTTQGYY 543 Query: 45 KKSADSTSTKTAKKPKKDER--------GALVNRMGVDPWHNWEAHYEVLPGKEKVVSEL 96 + P + R G G + +N E+L Sbjct: 544 GVVIKTGLFIPVYSPIRKCRDCGYQFTEGNKCPVCGSEDIYNAREQIEIL---------- 593 Query: 97 KQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE 156 ++LA + + + + TD D EGE IAW LR ++ R F+E+TK+AI +A + E Sbjct: 594 RRLAYECEDVIIGTDPDTEGEKIAWDLRNLLSPFAKSIKRAEFHEVTKDAIIKAIRESRE 653 Query: 157 LNIDRVNAQQARRFMDRVVGYMVSPLLWKKIAR-GLSAGRVQSVAVRLVVEREREIKAFV 215 + + V AQ RR DR +G+ +S +LW + LSAGR Q+ + ++ER + K + Sbjct: 654 FDENLVKAQIVRRIEDRWIGFELSHILWNVFGKKNLSAGRAQTPVLGWIIERYEKSKE-I 712 Query: 216 PEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 EE++ +P E + +V D E Y V Sbjct: 713 REEYFIKGTDVKSPWKENVLAKVEKIGD------------------EVKDYVV------- 747 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMV 335 P+ T + + A+T LG G ++ M + Q L+E+G ITY RTDST++SQ+ +++ Sbjct: 748 ------PPYTTDEILKDANTILGLGAREAMNILQDLFESGLITYHRTDSTHVSQEGMSIA 801 Query: 336 RGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPS------DV-NVMAESLKDMEA--D 386 + Y+ ++F P ++ + AHE IRP+ D+ + E + ++E + Sbjct: 802 KKYLGEDF-------RPRRWG----KEGAHECIRPTKPWSAEDIRRFVNEGILNLEIQDE 850 Query: 387 AQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE 446 A ++Y LI+R+F+A + + + +++ A+G++L ++ A K E Sbjct: 851 ALRIYDLIFRRFMASE--------SVGKIRISKYKVSAKGKVLEI---PLIVEAYGKSVE 899 Query: 447 --------DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYA 498 R LP + +E+ + P +++A +++ ++ R IGRPSTYA Sbjct: 900 LYPYRIKIYRPLPT-----GMVRIEVEKRKIKLAP---YTQADVIRLMKDRKIGRPSTYA 951 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 +IIS + R Y+ + + ++G V L N+ + ++ + T +E ++ V N Sbjct: 952 TIISKLFKRDYIVERSGKLIPTRIGIEVYSFLSTNYGKFVSEERTRILERKMEDVENGNR 1011 Query: 559 EWKAVLDHFFSDF 571 ++ VL+ + + Sbjct: 1012 DYLNVLNELYEEI 1024 >UniRef50_B8D628 Reverse gyrase n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D628_DESK1 Length = 1212 Score = 160 bits (406), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 169/599 (28%), Positives = 276/599 (46%), Gaps = 79/599 (13%) Query: 5 LVIVESPAKAKTINKYLG----------SDYVVKSSVG-------------HIRDLPTS- 40 LV+VESP KAKTI ++ G + Y + +G HI DL T Sbjct: 618 LVVVESPTKAKTIARFFGKPVARKLGDVTVYEIPVKIGGEIIHLNIVPTRGHIFDLTTGE 677 Query: 41 -GSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQL 99 G AD+ T + KK L H + +V+ L+++ Sbjct: 678 EGYYGVVIADNRVTPVYEYIKKCR---LCGTQFTTGDHCPRCGSRLFSDSRTIVAALRKI 734 Query: 100 AEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI 159 A + D +Y+ATD D EGE IA+ + + + + R+ +EIT +A N +N Sbjct: 735 AGEVDEVYIATDPDIEGEKIAYDVYLAVKYYNEKVWRIELHEITLQEFLKAINNKRGINQ 794 Query: 160 DRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVEREREIKAFVPEE 218 V + RR +DR+VG+ +S L R L AGRVQ+ + LV++R E ++ + Sbjct: 795 RLVEGEIYRRVLDRLVGFKLSQELQGIYGLRFLGAGRVQTPTLGLVIDRYEE---YMRNK 851 Query: 219 FWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 ++ +P ++ +N + R + + +L+ R + RE T Sbjct: 852 CKKIRFKLGSPLNIIYSV-FMGKNSEVIRELKTAK------MLKLVR---VGREIVTITP 901 Query: 279 KPGAPFITS-TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 KP P+ T L AA L G+ M +AQ+L+EAG ITY RTDS +S + + Sbjct: 902 KP--PYTTDELLSDAAKLNLHTGI--VMSIAQQLFEAGLITYHRTDSHYVSNTGIGIAMK 957 Query: 338 YISDNFGKKYLPESPNQYA--SKENSQEAHEAIRPS---DVNVMAESLKD--------ME 384 YI GKK YA S S HEAIRP D++ + +++ + + Sbjct: 958 YIE---GKKL-----EDYARPSHWGSPGTHEAIRPVYPYDLDDLLKAVSEGVINTVIPLT 1009 Query: 385 ADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM-PALRK 443 KLY LI+++F++ Q+ P K + V G+F+L G I + T ++ Sbjct: 1010 GMHLKLYDLIFKRFISSQLKPFKAVKSIYAVYFGEFKL---GEI---ELLTNIVEEGFNV 1063 Query: 444 GDEDRILPAVNKGDALTL-VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 ++ R+ ++ +++ + VE +K P F+E LV ++K G+GRPSTY+ II Sbjct: 1064 FEKTRVYKELDAVESIEVPVEEISVVDSSKSPL-FTEGELVSLMKKLGLGRPSTYSKIIE 1122 Query: 503 TIQDRGYVRVENRR--FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 +I+ GYV V +R K G V L + + EL++ + T ++E S+D++ N E + Sbjct: 1123 SIKRHGYVFVSKKRLKLIPSKRGIEVYGYLRDRYPELVSIEATRRLEESIDKIINGEVD 1181 >UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria RepID=C4NUW5_ECOLX Length = 730 Score = 160 bits (404), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 170/630 (26%), Positives = 266/630 (42%), Gaps = 86/630 (13%) Query: 99 LAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYS----RVVFNEITKNAIRQAFN-- 152 L +KA IY++TD DREGEAIA L D RYS RV + +++I++A N Sbjct: 90 LVKKASTIYISTDYDREGEAIARSLL-----DRFRYSGPIRRVCLTALDESSIKKALNNV 144 Query: 153 KPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVE 206 K G+ + A AR+ D +VG VS L+ +AR L GRV + V LV + Sbjct: 145 KDGKDTVSLYYAALARQRADWLVGMNVS-RLYTVLARDVGFNHTLHVGRVITPTVALVCQ 203 Query: 207 REREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ--NDKPFRPVNKEQTQAAVSLLEKA 264 R+REI F P +W + + + +G+ A + + +D+ R VNK + S + A Sbjct: 204 RDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEECSDEQGRCVNKAYAEQVASQVNGA 263 Query: 265 RYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTD 323 + + E KP PF ++LQQ AS R G+ ++ + AQ LYE TY RTD Sbjct: 264 NAVISKAETKPGKESAPLPFDLTSLQQYASKRWGYTAQQVLDAAQALYETHKATTYPRTD 323 Query: 324 STNL----SQDAVNMVRGYI-SD-NFGKKYLPESPNQYASKENSQE--AHEAIRPSDVNV 375 S L +D ++++ I SD N P++ A N + AH AI P+ Sbjct: 324 SRYLPESQKEDIPDILQALILSDQNVSGLVAGADPHRKARVFNDAKVTAHHAIIPTPART 383 Query: 376 MAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWT 435 ++ ++E + LY I R ++A + ++ T++ V G + G+ GW Sbjct: 384 DISAMSEIEFN---LYDAIRRFYIAQFYSEFEFTKTSIEVQCGRHLFASAGKTPTKQGWK 440 Query: 436 KVMPALRKGD------------EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLV 483 + + + E LP V++G+ L A T+P F+EA+L+ Sbjct: 441 VLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALLNGAELANKMTRPAPHFTEATLL 500 Query: 484 KELEK-----------------RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 +E G+G P+T ASII D+GY + + + A + Sbjct: 501 AAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGAVDKGYFKRQKKVLLATDKAHAL 560 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK----AEKDP 582 L + + TA E L++VA+ + + Q +++ A Sbjct: 561 IAVLPPAIK---SPGMTAAWEQELEKVASGSGNMSVFMKQISTWICQMVEQLKVAAPVLT 617 Query: 583 EEGGMRPNQMVLT---SIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPE 639 +EGG S +C CG +M G F GC E CK T P+ Sbjct: 618 KEGGAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQ------NEACKKTF---PD 668 Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAM 669 N G+ + A CP CG+ M Sbjct: 669 N------RGKPEKRIAAEDCPDCPDCGSPM 692 >UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae RepID=B4EXZ8_PROMH Length = 684 Score = 159 bits (402), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 169/615 (27%), Positives = 274/615 (44%), Gaps = 92/615 (14%) Query: 75 PWHNWEAHYEVLPGKEKVVSE---------LKQLAEKADHIYLATDLDREGEAIAWHLRE 125 PW ++ V+P + K+V + +KQL +A + +ATD DREGE IA RE Sbjct: 59 PWR--QSALPVIPEQWKMVVKKDAVSLFQTIKQLLSQATEVVIATDADREGEVIA---RE 113 Query: 126 VIGGDDAR--YSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRFMDRVVGYMVSP 181 ++ R R+ + + + +IRQA N PGE +A R D ++G ++ Sbjct: 114 LLEACHYRKKVQRLWLSALDEASIRQALNNLLPGEKTASLYSAGLGRARADWLIGMNMTR 173 Query: 182 LLWKK---IARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 L K + G LS GRVQ+ + L+V REREI FV + FW V AS + + Sbjct: 174 LFTLKARELGFGGILSVGRVQTPTLALIVRREREITHFVSKPFWRVTASL---QHQGIIF 230 Query: 237 QV-----THQNDKPFRPVNKEQTQAAVSLLEKA-RYSVLEREDKPTTSKPGAPFITSTLQ 290 Q + D R ++ + QA L +A + +V + + P PF TLQ Sbjct: 231 QAHWRPASQYCDDEHRCIHVQAAQAVEQLCRQAGKATVCTVNETKGKALPPLPFDLGTLQ 290 Query: 291 QAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTNLSQDA---VNMVRGYIS--DNFG 344 QAAS R G+ K + +AQ LYE TY RTD L + +V +S D Sbjct: 291 QAASRRWGYSADKVLEIAQSLYEKHKATTYPRTDCGYLPVSMRADIPVVLDALSQSDPAL 350 Query: 345 KKYLPE-SPNQYASKENSQE--AHEAIRPS----DVNVMAESLKDMEADAQKLYQLIWRQ 397 + L + P + + N + AH AI P+ D+N M E+ +Y+LI Sbjct: 351 QNVLAQLQPARISRVWNDAKITAHHAIIPTRQTPDLNAMNEA-------ELNVYKLIRAH 403 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------PALRKGDEDRI-- 449 ++A + ++D+T + + G + A+G++ R GW+ + P +++ E + Sbjct: 404 YLAQFLPDQEWDATEVFLDIGGQQFVAKGKVERVKGWSVLFVKHEDDPPVKEEAETGLEA 463 Query: 450 ----LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EK 488 LP++++G+ + E Q T PP +++ +L+ + E Sbjct: 464 GTETLPSLHEGEFCVVQEAKVVQLATSPPKPYTDGTLIAAMKNASSFITDPTLKKVLKEN 523 Query: 489 RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN 548 G+G +T A II+T+++R + + + A G + D L + TA E Sbjct: 524 AGLGTEATRAGIITTLENRKLIVRQKKTLRATDTGCQLIDALPA---ACTDPGMTALWEQ 580 Query: 549 SLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSI-DCPTCGRKMG 607 SL+QVA LD F +Q+ ++GG P + L + CP+C KM Sbjct: 581 SLEQVAQGNLS----LDVFMQ---KQISWLAHLIKKGGEMPLALDLPPMPSCPSCHGKMV 633 Query: 608 IRTASTGVFLGCSGY 622 +R +S G F C Y Sbjct: 634 LRESSKGRFWSCQRY 648 >UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J356_DESRM Length = 799 Score = 157 bits (398), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 188/689 (27%), Positives = 294/689 (42%), Gaps = 102/689 (14%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDL--PTSGSAAKKSAD 49 K LVI E P+ K I LG Y+V + GH+ +L P+ K D Sbjct: 2 KTLVITEKPSVGKDIASVLGRFESKDGYLENEKYIVSWAFGHLVELADPSVYDPVFKKWD 61 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIY 107 A P + LV E+ K + LK+L A+ + Sbjct: 62 -----LATLPIIPDSFKLV---------------EIAGSSAKQLRTLKKLLNSAEVSQVV 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQ 165 D REGE+I + G R+ +E T A++ AF + G+ + A Sbjct: 102 NGCDAGREGESIFRRIYHFCGCRKP-IKRLWLSETTPAAVKAAFKALREGQEYNNLAAAA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +AR D +VG + + LS GRVQ+ + L+V REREI FVP +WEV + Sbjct: 161 EARGQADWLVGLNGTRAFTVRHGTVLSVGRVQTPTLNLIVSREREINNFVPVPYWEVWGT 220 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 T +G + D+ P + L +A+ V+ E K P F Sbjct: 221 FQTDNGMYKGKWFREKEDR--LPNREAALNLTTKLSSEAKGQVISLEQKEAKELPSFLFN 278 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTNLSQDAVNMVRGYISD-NF 343 + LQ+ + R GF ++ + +AQ LYE +TY RTDS +LS ++ + ++ Sbjct: 279 LNDLQKEGNRRYGFTAQQVLDIAQSLYEKHKLLTYPRTDSRHLSNAMISTLPERLATLKN 338 Query: 344 GKKY-------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWR 396 KY LP +Y + H AI P+ V+ L D E +K+Y L+ R Sbjct: 339 APKYAELIPDTLPGLSKRYVD-DGKITDHHAIIPTAVDPSKAQLSDQE---KKIYDLVVR 394 Query: 397 QFVACQMTPAKYDST-TLTVGAGDFRLKARGRILRFDGWTKVMPALRK-------GD--E 446 +F++ A+Y T T AG+ K+RGR+ GW V + GD E Sbjct: 395 RFLSIFYPEARYAVTEVFTETAGEL-FKSRGRVELAAGWKMVWRGSDQETAEEGNGDDPE 453 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR----------------- 489 D+ LP + +G ++ + ++ + TKPP RF+EA+++ +E Sbjct: 454 DQALPPLTQGKSVDVSKVEILEKQTKPPKRFTEATILAAMESAGKFVEDKEMAEVLKQTG 513 Query: 490 GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENS 549 GIG P+T A+II + GYV + + G+I+ D + ++L + + TA E+ Sbjct: 514 GIGTPATRAAIIERLIKVGYVARDKKSLVPTAKGQILIDLVP---KQLKSVELTASWEDG 570 Query: 550 LDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID----CPTCGRK 605 L +V + A+ +T++L ++ E +Q V T+ D CP CGR Sbjct: 571 LRRVEEGQQN-AALWIQDIQAYTRELVVLARNQE-----VSQGVGTARDTLGKCPVCGRD 624 Query: 606 MGIRTASTGVFLGCSGYALPPKERCKTTI 634 + + TA + GCSGY KE CK I Sbjct: 625 V-VETAKS---YGCSGY----KEGCKFAI 645 >UniRef50_Q46AN3 DNA topoisomerase n=3 Tax=Methanosarcina RepID=Q46AN3_METBF Length = 855 Score = 157 bits (397), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 169/719 (23%), Positives = 306/719 (42%), Gaps = 76/719 (10%) Query: 73 VDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG-DD 131 V+P E + L + + +K LA++A+ I LA D DREGE I + + + + Sbjct: 69 VNPGVLLEIDPQKLVTRTDYAAAVKNLAKRANKIVLACDYDREGENIGFEAKTLAEKVTN 128 Query: 132 ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI---A 188 R F+ ++ +++AF + + A +AR+ +D +G + + + A Sbjct: 129 VPIERARFSSLSPKEVKKAFESLINPDYNMAMAAEARQILDLKMGAAFTRFVTLSVRERA 188 Query: 189 RG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDK- 244 R LS G Q+ V ERE+ I+AF ++FW++ A + SG+ + + K Sbjct: 189 RTKDILSIGPCQTPTCGFVYEREKAIRAFQAKDFWKITAIFSAESGKEGGKEGRKEGRKE 248 Query: 245 ----------PFRPVNKEQTQAAVSLLEKARYS----VLEREDKPTTSKPGAPFITSTLQ 290 R N + A + ++ + + V ++ K T + P P T+ Sbjct: 249 GKKERGDFEGTHRAGNIHDKEKAAEIFKRLKGTKEGLVAKKTVKETKTSPPNPLNTTEFL 308 Query: 291 QAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD------AVNMVRGYISDNFG 344 + AS LG + + +A++LY AG+ +Y RT++ ++D + R F Sbjct: 309 KRASKFLGISPELALEVAEQLYLAGFTSYPRTETNKYAEDFDFKSLVFDFARQKEYKPFA 368 Query: 345 KKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEA-DAQKLYQLIWRQFVACQM 403 + L +P + E H I P E + A ++Y LI R F+A M Sbjct: 369 ESILI-APIVPKNGEKDAHDHPPIHPIRAASRGEVSSAVNIPQAPEVYNLIARHFLANLM 427 Query: 404 TPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVE 463 A ++ T L + + + G +L+ GW + P K +D++LP V +G + + + Sbjct: 428 PAAVFEKTHLHLLVNEEPFDSSGTVLKDSGWLEAYPFENK--KDKLLPFVEEGQKVGVKK 485 Query: 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMG 523 L+ + T PP + +EA L+ ++K GIG +T + I T + RGY+ + + G Sbjct: 486 LSNTKSKTSPPKKLTEAELLTLMDKNGIGTKATAPTHIETNKKRGYLETKGKTISILDTG 545 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL---DHFFSDFTQQLDKAEK 580 + D L L+ + A++E + +V + + E++A L + QL+ +K Sbjct: 546 FTLMDGLSLTVPILVKPEIRAKIEALIQEVEDGKKEFEAALYEGTTLIKEMYAQLEANKK 605 Query: 581 D---------PEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCK 631 + +E + + + + C CG + I +G F+GC+GY C+ Sbjct: 606 ELTSSIAGTIKDEAALEDKKNYIGT--CKACGHVLRIVQTDSGRFVGCTGYP-----DCR 658 Query: 632 TTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNP--TC 689 + L P+ L VL ++ C K G A+ L + G P TC Sbjct: 659 NSYPL-PKAGALTVLRSKE-----------CKKGGVAV---LKVGNKYNWAVGIGPCFTC 703 Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEV 748 D E E GP C +C M L + +++ CT + C T + + G++ Sbjct: 704 D----LEKECYPPETVGP---CPECDGSMFLINFKDTRFLGCT-KRCGYTHSVPKTGKL 754 >UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms RepID=A0LAP8_MAGSM Length = 744 Score = 157 bits (397), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 171/603 (28%), Positives = 261/603 (43%), Gaps = 96/603 (15%) Query: 96 LKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNK 153 ++ L + + LATD DREGE I REV+ R SR+ + + +IR+A Sbjct: 86 IQGLLKGVTEVVLATDADREGETIG---REVLERCQYRGKISRLWLSALDDASIRKALGN 142 Query: 154 --PGELNIDRVNAQQARRFMDRVVGYMVS---PLLWKK--IARGLSAGRVQSVAVRLVVE 206 PGE A R D +VG ++ LL ++ A LS GRVQ+ ++LVV+ Sbjct: 143 LLPGEQTEPLYQAGLGRSRADWMVGMNLTRAYTLLGRQGGYAGVLSVGRVQTPTLKLVVD 202 Query: 207 REREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY 266 R+R I+ F P +++E+ A SG +A V P +P + E +L E + Sbjct: 203 RDRLIENFKPVDYFEIFALHRVHSGTFIAKWV-----PPPKPCDAEGHCLDRTLAETVIH 257 Query: 267 -------SVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YIT 318 ++ + E K P P STLQQ AS R G G K+T+ +AQ LYE +T Sbjct: 258 KVQGHSGTITKAETKRVKEPPPLPLELSTLQQEASRRWGMGAKQTLEIAQSLYEKHKAVT 317 Query: 319 YMRTDS----TNLSQDAVNMVRGYISDNFGKKYLPESPN-QYASK---ENSQEAHEAIRP 370 Y RTD +N ++A +++G +++ L E + Q SK + AH AI P Sbjct: 318 YPRTDCRYLPSNQFKEAPAVLQGLTTNDASLTPLVEGADAQLRSKAWNDKKITAHHAIIP 377 Query: 371 SDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILR 430 + + ++L EA LY LI R ++A P +YD T + A GR+ Sbjct: 378 TAAKINIDALSREEA---LLYDLIRRHYLAQFYPPFEYDRTVIDTQVAMETFHATGRVEL 434 Query: 431 FDGWTKVMPA---LRKGDED-RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL 486 GW +V+ A ++GDED + LP V G+A T+ Q TKPP R++E +L++ + Sbjct: 435 IPGWKRVLAANQEKKEGDEDEQTLPVVRSGEAATIEGAELKQKQTKPPNRYTEGTLIQAM 494 Query: 487 -----------------EKRGIGRPSTYASIISTIQDRGYVRVENRR-FYAEKMGEIVTD 528 E GIG +T A+I+ T+ R + + ++ + G ++ D Sbjct: 495 KSVGKLVEDARLRKILRETSGIGTEATRAAILETLIKRNLLAKQGKKSLVSMPAGRLLVD 554 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAE----------WKAVLDH------------ 566 L + + + TA E +LD +A+ W L H Sbjct: 555 ALPHS---VTDPATTAVWEQTLDDIAHGGGSLETFLAKSELWLNKLIHNVHQRQQLGLNP 611 Query: 567 --FFSDFTQQLDKAEKDPE-------EGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL 617 T D A+ P E PN L CP CG M R + G F Sbjct: 612 FRGLPPSTSHTDPAQPTPRRQRRSKAEVTPTPNAAPL----CPQCGGPMLQRKSPQGAFW 667 Query: 618 GCS 620 C+ Sbjct: 668 SCA 670 >UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0_BURP8 Length = 908 Score = 156 bits (395), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 178/674 (26%), Positives = 290/674 (43%), Gaps = 114/674 (16%) Query: 1 MGKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSAD 49 M KAL+I E P+ A I + LG D+V+ S+VGH+ ++ Sbjct: 23 MSKALIIAEKPSVANDIARALGGFTKHDEYFESDDFVLSSAVGHLLEI------------ 70 Query: 50 STSTKTAKKPKKDERG--ALVNRMGVDPWHNWEAHYEVLP-----GKEKVVSELKQLAEK 102 A + + +RG + N + P H+++ P + KV+++L + + Sbjct: 71 -----AAPEEYEVKRGKWSFANLPVIPP------HFDLNPIAKSESRLKVLNKLIKRKD- 118 Query: 103 ADHIYLATDLDREGEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNID 160 D + A D REGE I R + A+ R+ +T AIR+ F +L D Sbjct: 119 VDRLINACDAGREGELI---FRLIAQHAKAKQPVQRLWLQSMTPAAIREGF---AQLRTD 172 Query: 161 R-----VNAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVERERE 210 +A + R D +VG + + ++G + GRVQ+ + +VVERE + Sbjct: 173 AEMQPLADAARCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEK 232 Query: 211 IKAFVPEEFWEVDASTTTPSG--EALALQVTHQNDKPFRPVNKE----QTQAAVSLLEKA 264 I+ FVP ++WEV A SG E + D+ F P ++ AA +++ Sbjct: 233 IRRFVPRDYWEVKAEFVCASGFYEGRWYDPKFKKDE-FDPEKRDSRLWSLPAAETIVAAC 291 Query: 265 RYSV--LEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMR 321 R + E KP+T A F ++LQ+ A+ R GF K T+ +AQ LYE +TY R Sbjct: 292 RGQTGNVTEESKPSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPR 351 Query: 322 TDSTNLSQDAVNMVRGYI-----SDNFGKKYLPES----------PNQYASKENSQEAHE 366 TD+ L +D + V+ + S+N YLP + PN+ + H Sbjct: 352 TDARALPEDYLETVKHTMEMLKESNN----YLPHAKQVLDKGWVKPNKRIFDNSKISDHF 407 Query: 367 AIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARG 426 AI P+ ++ K + QKLY L+ ++F+A A+Y TT K G Sbjct: 408 AIIPT-----LQAPKALSEPEQKLYDLVVKRFLAVFFPAAEYRVTTRITEVVGHHFKTEG 462 Query: 427 RILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL 486 ++L GW +V G ED L V K + + ++ Q TKPPAR++EA+L+ + Sbjct: 463 KVLVEPGWLQVY-GRETGGEDANLVPVQKDEKVKTDKIAAQQLVTKPPARYNEATLLSAM 521 Query: 487 E----------------KRGIGRPSTYASIISTIQDRGYVRVENRRFY-AEKMGEIVTDR 529 E +G+G P+T A+II + Y+ E R K +++T Sbjct: 522 EGAGKLVEDDELREAMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLL 581 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 + +EL + T + E L Q+ + A + + TQ + K K+ + + P Sbjct: 582 RGLDVKELTAPELTGEWEYKLSQMERGKLPRDAFMQE-IARMTQTIVKRAKEYDSDTI-P 639 Query: 590 NQMVLTSIDCPTCG 603 CP CG Sbjct: 640 GDYATLQTPCPNCG 653 >UniRef50_Q4DQ13 DNA topoisomerase IA, putative n=3 Tax=Trypanosoma cruzi RepID=Q4DQ13_TRYCR Length = 830 Score = 156 bits (395), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 182/699 (26%), Positives = 288/699 (41%), Gaps = 138/699 (19%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKS---SVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 LVIVESP K + L VV H+R L A A + K+ + Sbjct: 12 LVIVESPNKVIKVEGLLSDPNVVPDWSFKQEHLRRLGVGAEKAVAMATTGHFMAMKEIQW 71 Query: 62 DERGAL---VNRMGVDPW------HNWEAHYEVLPGKEKVVSELKQLAEKADH---IYLA 109 R V G +P+ + +++LPG+ + + + EK ++ I LA Sbjct: 72 TPRAISFPEVRGAGEEPFPPNGTVAEYTLEWQLLPGRRIQETLERYIQEKLNNVTEIILA 131 Query: 110 TDLDREGEAIAWHLREVIGGDDAR----YSRVVFNEITKNAIRQAFNK--PGELNIDRVN 163 TD DREGE IA H + I + YSR + IT++ IR+A + + + D N Sbjct: 132 TDPDREGELIAVHALQTIKRLYPKLKVPYSRAYMHSITEDGIRKAMRERLVDKCDYDLAN 191 Query: 164 AQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEE----F 219 A + R MDR+ G++ S ++ ++ S GRVQ+ A+ L+ ERE +I AF+ + Sbjct: 192 AAETRHAMDRIFGFLGSSVVRAANSQMRSIGRVQTPALILIHEREEKIAAFLEKNKTNYI 251 Query: 220 WEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAV-----------SLLEKARYSV 268 +V P G + VT D V E + A L + ++V Sbjct: 252 VDVMCQFPGPHGTTFSQVVTINPD-----VKGEASHWATEAEARRCLHGWKLNNCSGFTV 306 Query: 269 -LEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNL 327 LE P+ P PF +T A+ L + Q L++ G+ITY RTDST + Sbjct: 307 PLEPLIVPSEVPPPQPFTMATAIAKANRHLKMSSETVSGCLQDLFQLGHITYPRTDSTRI 366 Query: 328 SQDAVNMVRGYISDNFGKKYL----------PES-PNQYASKENS--------------Q 362 + A+ + I FGK++L PE ++ K+NS + Sbjct: 367 DESALTDIYATIKKEFGKEFLYRLEDRTVSAPEGKKSKRTGKKNSTKQSKGADQPVGNVE 426 Query: 363 EAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV----GAG 418 +AHEAIRP+++ ESL + + +Y L+ R +A M P K + TV G+G Sbjct: 427 DAHEAIRPTNIYADGESL-SLPPMTRAVYDLVRRNTLASFMIPMKSEKIAATVKFTSGSG 485 Query: 419 D-FRLKARGRILRFDGWTKVM--------------------------------------- 438 D ++ G+ + GWT+ Sbjct: 486 DKLQVVLEGKRVAEPGWTRAFQKTDFTAAAAGAASSTNNTTDSSVNDKNTTGVAEEVTED 545 Query: 439 -------PALRKGDEDRILPAVNKGDALT------LVEL-TPAQHFTKP--PARFSEASL 482 P +R ++ N AL EL +P+ +P P SE +L Sbjct: 546 ITEKEGAPVIRSLSQEEFRAIANLRSALASLKQSRFFELRSPSVRENRPVPPLLHSEGTL 605 Query: 483 VKELEKRGIGRPSTYASIISTIQDRGYVRVENR-RFYAEKMGEIVTDRLEENFRELMNYD 541 ++EL+ G+GRPSTY I+ T+ RGY+ V + R +G ++ + F +++ Sbjct: 606 IEELKNNGVGRPSTYPMIVKTLLTRGYIAVNPKGRCETTPIGRLLVSTAKSTFPSIVDIG 665 Query: 542 FTAQMENSLDQVAN-HEAEWKAVL--------DHFFSDF 571 FTA E LD +A + A+ +L D+F S F Sbjct: 666 FTATFEKKLDLIAKPNPAKRPTILRGTNVSQADYFLSMF 704 >UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C5QM86_STAEP Length = 712 Score = 156 bits (394), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 188/723 (26%), Positives = 303/723 (41%), Gaps = 130/723 (17%) Query: 1 MGKALVIVESPAKAKTI----------NKYLGSD-YVVKSSVGHIRDLPTSGSAAKKSAD 49 M K+L++ E P+ A+ I N Y+ ++ Y+V ++GH+ +AA + D Sbjct: 1 MMKSLILAEKPSVARDIADALHIKNKKNGYIENEKYIVTWALGHL-----VTNAAPEQYD 55 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKE----KVVSELKQLAEKADH 105 ++ K+ K ++ + M ++ GK K+V L L +K Sbjct: 56 AS----YKEWKLEDLPIIPKYMKT-----------IVIGKTSKQFKIVKSL-ILDKKVKD 99 Query: 106 IYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVN 163 I +ATD REGE +A + + +G R+ + +TK AI++ F K G + Sbjct: 100 IIIATDAGREGELVARLILDKVGNKKP-IQRLWISSVTKKAIQEGFKHLKDGRAYNSLYH 158 Query: 164 AQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD 223 A AR D +VG + L K LS GRVQ+ ++LV R+ +I F PE+++ Sbjct: 159 AALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVQSRQDDINHFQPEKYY--- 215 Query: 224 ASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 T S + + T K F+ NK+ + ++ V++ + K P Sbjct: 216 ----TLSIKVDGYEFTFNTQKHFK--NKKDLETIEQQVKNQEGKVIDVKSKHKKLYPQQL 269 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVR----GY 338 + + +QQ A R G K+T+ Q LYE I TY RTDS L+ D V+ ++ Sbjct: 270 YNLTDIQQDAYRRFKMGPKETLNTLQHLYERHKIVTYPRTDSNYLTHDMVSTIKERLQAL 329 Query: 339 ISDNFGKKYLPE------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQ 392 ++ N+ K ++ E SP ++ H AI P++V E L E K+Y Sbjct: 330 LATNY-KSHVRELIGQSFSPKMSIFNDSKVSDHHAIIPTEVRPSLEQLSQREF---KIYM 385 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPA 452 LI +F+ M P +Y+ T+ GD + I + G+ AL+ ED + P+ Sbjct: 386 LIVERFLESLMKPYEYEGVTVNFEVGDLMFSLKENIPKQLGF----KALK---EDTLQPS 438 Query: 453 VNK----GDALTLVELTPAQHFTKPPARFSEASLVKELEK-------------------R 489 + G + ++ +H TKPP F+E SL+K +E Sbjct: 439 KSHQFVIGQQFKVQKVDIHEHETKPPEYFNEGSLLKAMENPQNYIQLDNKKYAQTLKQTG 498 Query: 490 GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENS 549 GIG +T A II + + + V + + G+ + LE EL + TAQ E Sbjct: 499 GIGTVATRADIIDKLFNMNALEVRDGKIKVTSKGKQI---LELAPSELTSPLLTAQWEEK 555 Query: 550 LDQVANHEAEWKAVLD---HFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKM 606 L Q+ K +D HF D Q++ +E+ + LT+ +CPTCG+ M Sbjct: 556 LTQIEKGRYNSKKFMDEMKHFTKDIVQKIKSSEQKYKHDN-------LTTTECPTCGKFM 608 Query: 607 GIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 G L C + CKT N+ +TNA RCP C Sbjct: 609 IKVKTKNGQMLVCQDPS------CKTKKNI-------------QRKTNA-----RCPNCK 644 Query: 667 TAM 669 M Sbjct: 645 KKM 647 >UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK25_9FIRM Length = 765 Score = 156 bits (394), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 188/694 (27%), Positives = 295/694 (42%), Gaps = 129/694 (18%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ A+ I + LG S+Y+V ++GH+ L KK Sbjct: 2 KSLVLAEKPSVARDIARVLGCHKNISGAIEGSNYIVTWALGHLVTLADPEEYDKKFKAWD 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATD 111 + PKK E +V + +HN + K VSE I +ATD Sbjct: 62 MSYLPMVPKKWE--LVVIKQTSKQYHNVKTQLF-----RKDVSE----------IIIATD 104 Query: 112 LDREGEAIA-WHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQAR 168 REGE +A W L + G R+ + +T AI++ F K G D +A ++R Sbjct: 105 AGREGELVARWILDK--SGCHKPIRRLWISSVTDKAIKEGFAHLKDGRAYNDLYHAARSR 162 Query: 169 RFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D +VG + L K LS GRVQ+ + ++ RE++I++F PE+++ + +T+ Sbjct: 163 AEADWLVGINATRALTCKYNAQLSCGRVQTPTLAMIAHREQQIRSFKPEDYYGLRCTTSV 222 Query: 229 PSGE----ALALQVTHQNDK--PFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSK--- 279 G A + T Q K R NK+ L +K + L D T+SK Sbjct: 223 TGGSVGTMASIVTWTWQQKKSGSLRSFNKD---LITGLDKKLKNQTLTVTDVHTSSKRTP 279 Query: 280 -PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTNLSQDAVNMVRG 337 PG +T LQ+ A+ R GF K+T+ + Q LYE +TY RTDS + D V ++ Sbjct: 280 SPGLYDLTE-LQRDANKRFGFSAKETLNIMQSLYEHHKVLTYPRTDSRYIGTDIVPTIKE 338 Query: 338 YI-SDNFG--KKYLPE------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ 388 + + N G KKY+PE ++ + H AI P++ V E + + E + Sbjct: 339 RLKACNIGPYKKYIPELLKKPLKTSKAFVDDKKVSDHHAIIPTEEYVQMEHMSNNE---R 395 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRK----- 443 K+Y L+ R+F++ +Y+ TTL A A+G++++ GW V Sbjct: 396 KIYDLVVRRFISVLYPAFEYEQTTLKAEAAGETFTAKGKVIKAAGWKAVYADAASSGSSA 455 Query: 444 ------GD--------------------EDRILPAVNKGDALTLVELTPAQHFTKPPARF 477 GD ++ LP ++KGD LT+ TK PARF Sbjct: 456 SQYDAYGDYEDSEDFGEDFQNNDMYLKASEQALPVLHKGDTLTVTRTNITSGKTKAPARF 515 Query: 478 SEASLVKELEK-------------------RGIGRPSTYASIISTIQDRGYVRVENRRFY 518 +EA+L+ +E G+G +T A II + F Sbjct: 516 TEATLLSAMENPVRYMSSDDNKMKKTLGETGGLGTVATRADIIEKL---------FHSFL 566 Query: 519 AEKMG-EIVTDRLEENFRELMNYD-----FTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 EK G EI+ + EL+ D TA E L ++A A + V +T Sbjct: 567 LEKKGNEILLTSKGKQLLELVPEDLKKPELTASWEMELAKIAKG-AHKEQVFIKDIESYT 625 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKM 606 ++L + K +G R + LT+ CP CG++M Sbjct: 626 KELIQDIK-TSDGTFRHDN--LTNTKCPHCGKRM 656 >UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU08_GEOTN Length = 706 Score = 155 bits (391), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 150/602 (24%), Positives = 279/602 (46%), Gaps = 69/602 (11%) Query: 76 WHNWE-AHYEVLPG---------KEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLRE 125 W W+ A ++PG K K +K+L ++AD I +ATD REGE IA L Sbjct: 62 WKKWDLATLPIIPGQFEYKVSKDKAKQFQTVKKLLKEADEIIIATDPAREGENIARLLIL 121 Query: 126 VIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFMDRVVGY----MV 179 + G R R + +T+NAIR+ F K G+ I + QAR+ D +VG + Sbjct: 122 MAGCSKKRIKRFWTSSLTENAIRKGFAELKDGKETIHLFHEAQARQIADWLVGMNASRLY 181 Query: 180 SPLLWKKIARGL-SAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 + LL +K R + S GRVQ+ ++L+ +R++EI+ F PE F+E++ T +G Sbjct: 182 TLLLQQKGIRDVFSVGRVQTPVLKLIYDRQKEIEQFRPEPFYELEGQFTVKNG------- 234 Query: 239 THQNDKPFRPVNKEQTQAAVS---LLEKARYSVLEREDKPTTSKPGAPFI--TSTLQQAA 293 T++ R + ++ AVS E+ Y + + + + + AP + STLQ Sbjct: 235 TYRGKLNKRFSSPDELYEAVSPDITKEQQTYQAVIKSVRISEKRTPAPKLHSLSTLQSKL 294 Query: 294 STRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGK---KYLP- 349 + F K + + Q LYE GY++Y RTDS ++++ ++ ++ D + + ++P Sbjct: 295 NRTKKFSPTKVLELVQSLYEKGYVSYPRTDSQYITEEEYTYLQKHV-DQYQQCLGIHVPI 353 Query: 350 ---ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPA 406 + +Y + E + H AI P++ ++ + +D +++Y I + +A MT Sbjct: 354 RSLQPSKRYVNPEKVSD-HYAIIPTEKVPDTKAFETFSSDEKEVYYEILKSALAMFMTDY 412 Query: 407 KYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR----KGDEDRILPAVNKGDALTLV 462 YD T + G +GR + GW + + +G++ ILP V +G++ Sbjct: 413 VYDETVIITSVGKQEFVTKGRTEKEMGWKALYQNEKDEESEGEQVAILPEVKEGESAK-A 471 Query: 463 ELTPAQHFTKPPARFSEASLV------------KELEK-----RGIGRPSTYASIISTIQ 505 +++ Q T+PP +++ L+ +E+++ G+G +T A+II T+ Sbjct: 472 DISVKQGMTQPPKPYTQGQLITLMKTAGKYVEDQEMKEALNQVEGLGTEATRAAIIDTLI 531 Query: 506 DRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD 565 R + V+ + + K GEI+ + ++ L + TA+ E L ++ + ++ Sbjct: 532 QRRLIEVKKNQVFVTKKGEILCEAVKGTI--LSKPEMTAKWELFLQEIGKGNRSKEVFIE 589 Query: 566 HFFSDFTQQLDKAEKDPE----EGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG 621 + +A +D E + + + T CP C + + + F GC+ Sbjct: 590 QAKKLCYALIQQASQDVERIDAKQALEEIKKENTIAPCPRCQKGYIVDRKT---FYGCTE 646 Query: 622 YA 623 YA Sbjct: 647 YA 648 >UniRef50_A4RZ61 DNA topoisomerase n=2 Tax=cellular organisms RepID=A4RZ61_OSTLU Length = 863 Score = 155 bits (391), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 148/522 (28%), Positives = 233/522 (44%), Gaps = 54/522 (10%) Query: 91 KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGD-----------DARYSRVVF 139 ++V L++ A D++ L D DREGE I + + E G AR R F Sbjct: 108 RMVGHLEREARGCDYLVLFLDCDREGENICFEVMEACAGGLKTGATEPGAPSARILRAKF 167 Query: 140 NEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI--------ARGL 191 + +T+ +I +A GE N + A AR+ +D +G + + AR + Sbjct: 168 SAVTRESIERAMRTLGEPNRNEALAVDARQELDLKMGVAFTRFQTQYFLNKYDRLDARVV 227 Query: 192 SAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS-TTTPSGEALALQVTHQNDKPFRPVN 250 S G Q+ + V+R EI VPE +W +DAS +G+ +A + R + Sbjct: 228 SYGPCQTPTLGFAVQRHLEIIRHVPEPYWALDASFDDAATGDTIA-----PAWRRTRLFD 282 Query: 251 KEQTQAAVSLLEKA---RYSVLEREDKPTTSKPGAPFITSTLQ--QAASTRLGFGVKKTM 305 +E T+A + L+ A R + +E + K G P +T++ +AAS LG G + M Sbjct: 283 EETTRAFLQLVNDANEFRVTSIEVNAE----KRGRPSGLNTVEMLKAASAGLGMGAHRAM 338 Query: 306 MMAQRLYEAGYITYMRTDST------NLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE 359 +A+RLY AG+I+Y RT+ST L Q F + L ES + Sbjct: 339 QVAERLYMAGHISYPRTESTAYPRGFELKQTLTIQKSHPTWGAFVSRLLDESSMTSPKRG 398 Query: 360 NSQEAHEAIRPSDVNVMAESLKDM--EADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA 417 H I P M S +D +A +LY I R F+A +Y++ T T+ A Sbjct: 399 VDAGDHPPITP-----MRASTEDQVGGGEAWRLYDFISRHFIASVSPDCEYETQTATLDA 453 Query: 418 GDFRLKARGRILRFDGWTKVMPALRKGDEDRILP-AVNKGDALTLVELTPAQHFTKPPAR 476 G +G+ + GWT++MP + ED LP V +G + L + T PP Sbjct: 454 GGEEFTLQGKRVIEHGWTEIMP--HRMIEDSSLPVCVVQGARIPLKSVRLRSESTSPPEY 511 Query: 477 FSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRLEENFR 535 +E+ L+ +EK GIG ++ + I+ IQ R YV V + RR ++G + Sbjct: 512 LTESELIGLMEKNGIGTDASIPTHINNIQVRKYVDVAKGRRIVPSQLGITLVQGYHAIDS 571 Query: 536 ELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 EL+ +E LD VA +A ++ V+ H + Q DK Sbjct: 572 ELVLPTVRRHVERQLDLVAKGQAPYEGVVAHILA---QMFDK 610 >UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris RepID=B8DNH0_DESVM Length = 873 Score = 154 bits (389), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 195/766 (25%), Positives = 316/766 (41%), Gaps = 155/766 (20%) Query: 1 MGKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSAD 49 M K L+I E P+ A+ + +G+ D++V +VGH+ G A + D Sbjct: 1 MSKTLIIAEKPSVARELAPLVGATQRRAGFLEGPDHLVSWAVGHL-----VGIAEPEEQD 55 Query: 50 STSTKTAKKPKKDERGALVNRMGVD--PWHNWEAHYEVLPGKEKVVSELKQLA--EKADH 105 A R +D P VLP + L++L E+ Sbjct: 56 P---------------AWAGRWTLDQLPMLPPRFRLRVLPETADQFAVLRRLLTDERVTG 100 Query: 106 IYLATDLDREGEAIAWHLREVIGGDDARYSRVVF-NEITKNAIRQAFNK--PGELNIDRV 162 + ATD REGE I R + + A+ R ++ +++T+ +R++ + P + Sbjct: 101 VINATDAGREGELI--FRRIYLMAECAKPVRRLWASDMTEEGLRKSLARLLPDAEKRNLG 158 Query: 163 NAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 A AR D +VG S L + +S GRVQ+ + L+ R REI+ FVP++FW V Sbjct: 159 LASFARAEADWLVGMNYSRLFTVRTGGLVSVGRVQTPVLCLLTARRREIEQFVPQDFWTV 218 Query: 223 DASTTTPSGEALALQ------------------------VTHQNDKP-------FRP--- 248 + TP G+ A Q +D P RP Sbjct: 219 EG-VFTPGGKGRAAQGGVAAPDASPDATADASPAGTQDTPAPASDAPDSFPAVWHRPPEL 277 Query: 249 ----VNKEQTQAAVSLLEKARYSVLER-EDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 V+ E +A++ R V+E K + +P PF +TLQ+ A+TR G K Sbjct: 278 RETRVDSEDEASAIANACTGREGVVESVASKAGSQQPPLPFDLTTLQREANTRFGLSAKD 337 Query: 304 TMMMAQRLYEAG-YITYMRTDSTNLSQD----AVNMVRG----YISDNF--------GKK 346 T+ AQ LYE ITY RTDS +L+++ +N R Y + GK Sbjct: 338 TLAHAQALYETHKLITYPRTDSRHLTKELFAEILNHFRAIHHLYPDETMLAVARIKSGKV 397 Query: 347 YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPA 406 P ++ + H AI P+ L E +++Y++I R+F+A A Sbjct: 398 KFPCVDDRKVTD------HHAIIPTARKGDPARLSQPE---RQIYEMICRRFIAAFCAEA 448 Query: 407 KYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTP 466 ++ ++T+TV G+ ARG++ + GW V P + ED LP + KG L ++ Sbjct: 449 RFATSTVTVKVGEHAFIARGKVFKEKGWLAVEPW--RAAEDTPLPPLRKGARLHTDDIRR 506 Query: 467 AQHFTKPPARFSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYV 510 TK PA +++ASL+ +E +RG+G P+T A +I T+ RGYV Sbjct: 507 VTRQTKAPAHYTDASLLAAMETAGKLVEDEELRQAMKERGLGTPATRAQVIETLLQRGYV 566 Query: 511 RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 +R A G V + +E ++ + + T E +L + A + + Sbjct: 567 GRHGKRLIASDRGMQVAEVIEALLPDVASPELTGTWEKALKDMEAGTATYPQFMHGIRES 626 Query: 571 FTQQLDKAEKDPEEGGMRPNQMVLTSID---------CPTCGRKMGIRTASTGVFLGCSG 621 + + ++ GG ++++ T+ + CP CG + +R G C+G Sbjct: 627 VWNGVHRIKR---VGGRNLDRLLDTASERYARTPDGLCPLCGGE--VRETPRG--WACTG 679 Query: 622 YALPPKERCKTTINLVPENEVLNVLEGED-AETNALRAKRRCPKCG 666 P K+R K G+D A +A RAKR K G Sbjct: 680 QP-PAKKRGKAA-------------NGDDSAGQDAARAKRGAKKTG 711 >UniRef50_A9VVE2 DNA topoisomerase n=18 Tax=Bacillus cereus group RepID=A9VVE2_BACWK Length = 714 Score = 154 bits (389), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 180/725 (24%), Positives = 313/725 (43%), Gaps = 84/725 (11%) Query: 4 ALVIVESPAKAKT-------INKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTA 56 LV+ E P +AK + K G YV S+ LP+ G+ K+ Sbjct: 3 VLVLAEKPNQAKAYAEAFPKVEKREGHFYVPPCSL-----LPSGGNITWAYGHLVELKSP 57 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREG 116 + KK+ ++++ + P Y+V K+K + +K+L ++AD + D+DREG Sbjct: 58 QDYKKEWEKWDLSQLPILPSR---YEYKVSADKKKQFNIVKKLMKEADTTVVDVDIDREG 114 Query: 117 EAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFMDRV 174 EAIA + + G + R+ N + + I++ F KPGE QAR+ D + Sbjct: 115 EAIARLIIQEAGCTHKKIKRLWINSLEVDEIKKGFQNLKPGEDFESMFEEAQARQLSDWI 174 Query: 175 VGY----MVSPLLWKKIARGL-SAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 VG + + LL +K +G+ S GR Q+ A+ L+ +R++EIK F P F+E++A T+P Sbjct: 175 VGMNASRLYTLLLRQKGVQGVYSVGRCQTPALCLINKRQQEIKNFKPTPFFELEAQFTSP 234 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTL 289 +G + + + +N Q Q ++S + V E KP + F S++ Sbjct: 235 NGVYMG-RYKERFTTKGELMNLLQ-QHSISENSSQQGMVKSVEVKPKQQEATKLFSLSSI 292 Query: 290 QQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV----NMVRGY---ISDN 342 Q A+ + + + Q LYEA +TY RTD +++ N + GY S N Sbjct: 293 QALANKKYKYSPADVLKGIQELYEAKLVTYPRTDCNYITEGEFEYLKNNLSGYQSIASVN 352 Query: 343 FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQ 402 F L + +Y + QE H AI + E++ + + LY + + ++ Sbjct: 353 FQPHSLT-ANKRYVDNKKVQE-HYAIVLTKNVPSRETIARLPDKQRNLYMEVLKSVLSMF 410 Query: 403 MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED-----RILPAVNKGD 457 P Y+ T +T +G+ + GW ++ + +ED +LP V +G+ Sbjct: 411 YAPYMYEETVITSDLNGLLFTTKGKAEKSLGWKELYVTDKIEEEDDQEKVSLLPVVKQGE 470 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYASI 500 + + + + T PP ++E L+ + E G+G +T A I Sbjct: 471 FVQGL-VKSKEGVTTPPKPYTEGQLITMMKTCGSSVEDEESKIILKEVEGLGTEATRAGI 529 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 I T++ +GY+ V+ + GEI+ + ++ L + TA+ E L ++ + Sbjct: 530 IETLKKQGYIEVKRNKVSVTPKGEILCESVQGTM--LAKPELTAKWEGYLRKIGKEQGS- 586 Query: 561 KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVL------TSIDCPTCGRKMGIRTASTG 614 K + S+F + L K E G ++ + + T CP CG+ + R Sbjct: 587 KDIFVSQTSEFIKDLIK-EATESIGELKIDNKIQDMKAKDTIGKCPKCGKDVVNRKT--- 642 Query: 615 VFLGCSGYALPPKERCKTTIN------LVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 F GCSGY KE CK +++ + E +LEG+ K+ K G Sbjct: 643 -FYGCSGY----KEGCKFSMSGEYLTKKISEANAKKLLEGKKTGL----IKKMKGKSGKE 693 Query: 669 MDSYL 673 D YL Sbjct: 694 FDGYL 698 >UniRef50_D2RGC8 DNA topoisomerase n=2 Tax=Archaeoglobaceae RepID=D2RGC8_ARCPR Length = 648 Score = 154 bits (389), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 161/602 (26%), Positives = 268/602 (44%), Gaps = 73/602 (12%) Query: 96 LKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDD--ARYSRVVFNEITKNAIRQAFNK 153 L +LA+ A+ + +ATD DREGE I ++I + + RV F+ +T +R+AF Sbjct: 88 LLELAKDAERVTIATDYDREGEFIGLTAVKLIQKVNPGVKIERVRFSALTPVDVRRAFEN 147 Query: 154 PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIAR----GLSAGRVQSVAVRLVVERER 209 P L+++ + + R +D + G +++ LL R LS GRVQS +RL+VERE Sbjct: 148 PTSLDLNLAKSAEVRHKVDLLWGAILTRLLSLSANRLGRDFLSVGRVQSPTLRLIVEREE 207 Query: 210 EIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVL 269 +IK+F + ++ + R KE+ AV L VL Sbjct: 208 QIKSFKSKYYYNAFVKVRGIYAK--------------RKFEKEEEAKAV-LESINTLKVL 252 Query: 270 EREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ 329 + K PF T+ + AS + K M +A+ LY GYI+Y RTD+T + Sbjct: 253 SFKKSVVEEKKPIPFNTTEFLKEASKFMK--PDKAMAIAENLYMEGYISYPRTDNTVYPK 310 Query: 330 --DAVNMVRGYISDNF--GKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEA 385 + +V ++S +F +++ + + + H I P+ V S ++ Sbjct: 311 TLNLKKLVEMFLSSDFKDHAEFVLKHGIEPSRGRKETSDHPPIHPTAV----ASKDELSK 366 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD 445 D +Y+L+ ++F+A AK++ + G KA G+ L F GW + + Sbjct: 367 DEWTIYELVVKRFLATLAPKAKWEVKRVEFEQG---FKAMGKKLIFAGWRLIYDYSK--P 421 Query: 446 EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQ 505 E+ +P G+ L + E + TKPP+R++ +L+K +E G+G ST II + Sbjct: 422 EESYIPDFKVGEVLVVEEKKIKKEKTKPPSRYTTGTLIKVMESLGLGTKSTRHEIIKKLY 481 Query: 506 DRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD 565 DR Y+ R + V + L+E + D TA++E + +A + K VL Sbjct: 482 DRKYIYGNPIR--PTNLAFAVINALKETAEVVTLPDMTAKLERDMTAIAEGRIDEKDVLK 539 Query: 566 H---FFSDFTQQLDK----------AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAS 612 F S + +D+ EKD EE M N + CP CG + ++ A+ Sbjct: 540 ESVVFLSRILKSVDRERLGSIIKEGIEKDREE-EMEKNAIG----SCPECGGVLLVKRAN 594 Query: 613 TGVFLGCSGY-------ALPPKERCKTTINLVPEN--EVLNVLEGEDAETNALRAKRRCP 663 F+GCS Y LP K R TT + ++ ++L ++E + R CP Sbjct: 595 KR-FIGCSNYPKCKFSRPLPQKGRLVTTSKVCEKHGVKILRIVEKD-------RKWEFCP 646 Query: 664 KC 665 C Sbjct: 647 LC 648 >UniRef50_B1YAK4 DNA topoisomerase type IA central domain protein n=4 Tax=Thermoproteaceae RepID=B1YAK4_THENV Length = 604 Score = 154 bits (389), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 138/493 (27%), Positives = 224/493 (45%), Gaps = 38/493 (7%) Query: 87 PGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG--GDDARYSRVVFNEITK 144 P V L+ LA+KA+ +YLA D D EGEAIA+ V+ A RV FN +T Sbjct: 83 PETANYVKALRSLAKKAERVYLALDADVEGEAIAYEAALVVKLVNRRAEIYRVRFNAVTY 142 Query: 145 NAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI------ARGLSAGRVQS 198 +R AF KP +L++ +V R +D +G + + L + R LS G Q+ Sbjct: 143 RDVRSAFQKPTKLDLRQVEKVFTRMQIDLTLGAVFTRFLTLTVRNSLERGRFLSYGPCQT 202 Query: 199 VAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAV 258 + +VV RE + + F PE+++ + A G A+ + T + +E AA Sbjct: 203 PVLGIVVTRELQRRNFKPEKYYVIKALVEI-GGHAVEMASTERFK-----TRREAETAAA 256 Query: 259 SLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT 318 S+ + + R+ +P P T L++ AS LG KK + A+ LY AGYI+ Sbjct: 257 SVKRGVVKTAVYRQH---AVQPPEPLETVELERRASRWLGISSKKALDTAEELYRAGYIS 313 Query: 319 YMRTDST------NLSQDAVNMVRG----YISDNFGKKYLPESPNQYASKENSQEAHEAI 368 Y RT++T +L + + G Y + + + P ++ AH I Sbjct: 314 YPRTETTIYPSTLDLREVLKELAGGEHGPYAEELLKRGFKP------TRGDSDDGAHPPI 367 Query: 369 RPSDVNVMAESLK---DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKAR 425 P+ E K + A +Y L+ R F+A PA + + G L+A Sbjct: 368 YPTRGATQGEIYKVFGKLGRQAWAIYDLVVRHFLATLSPPALVEKQRIVATFGGVELEAE 427 Query: 426 GRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKE 485 G+ +G+ ++ P R+ D+ LP V G+A + + + T+PP + SE+ L+ Sbjct: 428 GQRTIEEGYWRIYPWERQ--RDKPLPRVEAGEAAKAIRVEVVERETEPPPQMSESELLAL 485 Query: 486 LEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQ 545 ++K GIG +T I T RGY+R++ + K+GE + L + EL+ A+ Sbjct: 486 MKKYGIGTDATMQDHIHTNVKRGYMRLQRGKCIPTKLGEALATALFQYAPELIEPTVRAK 545 Query: 546 MENSLDQVANHEA 558 ME +L V A Sbjct: 546 MEKALQDVVRGAA 558 >UniRef50_Q9YC75 Topoisomerase n=4 Tax=Archaea RepID=RGYR2_AERPE Length = 1215 Score = 153 bits (387), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 159/604 (26%), Positives = 263/604 (43%), Gaps = 78/604 (12%) Query: 5 LVIVESPAKAKTINKY--------LGSDYVVKSSV-----------------GHIRDLPT 39 L++VESP KA+TI + +G + ++SV GH+ DL T Sbjct: 620 LLVVESPTKARTIAWFWGRPGKRRIGRSVIYEASVSDPETGDVHILQITSTRGHLTDLTT 679 Query: 40 SGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEK------VV 93 +K D +R + H + + G + VV Sbjct: 680 DSVGSKYGVDEDGGGYRAYYSTIKRC-----LDCGAQHTSSSPFCPRCGSPRQVDSKSVV 734 Query: 94 SELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK 153 L++LA + D I +ATD DREGE IAW + + + R F+E+T A+ +A Sbjct: 735 EILRKLASEVDEIVIATDPDREGEKIAWDVFLAVRPYNPNVRRGRFHEVTPRAVIEALRS 794 Query: 154 PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIAR-GLSAGRVQSVAVRLVVEREREIK 212 + + AQ+ RR +DR +G+ +S L K ++ L AGRVQ+ + +V+R RE Sbjct: 795 GESVEKSLIEAQKVRRIVDRWIGFHLSTHLKLKFSKPWLGAGRVQTPVLGWIVDRYRE-- 852 Query: 213 AFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY-SVLER 271 W+ + V + R Q + V L++ + V++ Sbjct: 853 -------WQ----------DTRGYLVIFKLSSGGRTSYFTQNRLEVENLKRVEWLEVVDI 895 Query: 272 EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA 331 K P P+ T AS +LG M +AQ L+E+G ITY RTDST +S Sbjct: 896 AGKTEERNPPPPYTTDEYLYDASRKLGLSAGLAMKIAQDLFESGLITYHRTDSTRVSPTG 955 Query: 332 VNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVN-----VMAESLK---DM 383 V + Y++ + E+ + + + EA +RP D V++ S++ + Sbjct: 956 VKLALEYLAS---RGLEGEAQPRGWGEGGAHEAIRPVRPIDAQDLERAVLSGSIRIPIRL 1012 Query: 384 EADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRK 443 ++Y +I+R+F+A QM PA D T+ AG+ G G+ V P Sbjct: 1013 TRLHIRVYDMIFRRFIASQMKPATLDIVEATLQAGETVFNHAGVARVRGGYALVNPP--- 1069 Query: 444 GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 503 + L ++ GD + + ++ + K R + +VK + + GIGRPSTYA I Sbjct: 1070 -RVEEWLARLSPGDRIDVEDVLVVKSSLKRLYRAGD--IVKMMREHGIGRPSTYAKAIEQ 1126 Query: 504 IQDRGYVRVEN---RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 + GYV +E+ R K G + D L F++L++ D T ++E +L++V + Sbjct: 1127 NRRHGYV-IESKKMRYLIPTKTGVSIYDYLSNGFKKLVSVDTTRRLEEALERVEKGVEKP 1185 Query: 561 KAVL 564 +AVL Sbjct: 1186 EAVL 1189 >UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIS7_9BACT Length = 867 Score = 151 bits (382), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 200/821 (24%), Positives = 325/821 (39%), Gaps = 172/821 (20%) Query: 1 MGKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSAD 49 MGK LVI E P+ A+ I + LG ++VV S+VGH+ +L + D Sbjct: 1 MGKTLVITEKPSVARDITRALGGFQNEKNFFEGPEHVVTSAVGHMLEL--------VAPD 52 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLP--GKEKVVSELKQLAEK--ADH 105 + K ALVN + V P H+++ P E + +K+L + D Sbjct: 53 GVEVQRGK-------WALVN-LPVIP-----DHFDLKPIQQNESQLKLIKKLYARKDIDS 99 Query: 106 IYLATDLDREGEAIAWHL-REVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRV 162 + A D REGE I +L R G R R+ +T AIR F + GE + Sbjct: 100 VINACDAGREGELIFHYLIRHFKGSKPVR--RLWLQSMTPQAIRDGFERLRDGETLLPLQ 157 Query: 163 NAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPE 217 A R D ++G + + + G + GRVQ+ + L+V+RE+EI+ F P Sbjct: 158 RAAVCRSESDWLIGINATRAMTALNSSGGGFSLTTVGRVQTPTLALLVDREKEIQHFEPR 217 Query: 218 EFWEVDASTTTPSGEALALQV-------------------THQNDKPFRPVNKEQTQAAV 258 E+WEV A SG V H KP R +K + +A V Sbjct: 218 EYWEVKAIFAIASGRYEGYWVDPQLQPRSKQGVTPGAAKDQHGTAKPERIWDKTRAEAIV 277 Query: 259 SLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE-AGYI 317 + V E KP++ +P F ++LQ+ A+ R GF K T+ +AQ LYE + Sbjct: 278 AQCANREGRVSE-TTKPSSQQPPMLFDLTSLQREANRRFGFSAKTTLGIAQALYERHKVL 336 Query: 318 TYMRTDSTNLSQD----AVNMVRGYISDNFG----------------------KKYLPES 351 TY RTDS L +D +++ +S G +++ Sbjct: 337 TYPRTDSRTLPEDYPKTVGTIMQSLVSSAAGPGAASSDAEGDRPISHWAERVLQEHYING 396 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 N+ H AI P+ E+ ++ +++Y+L+ R F+A PA++++T Sbjct: 397 KNRRIFNNAQVSDHFAIIPT-----GEAPGKLKEQERRIYELVTRCFIAAFYPPARFENT 451 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILP----AVNKGDALTLVELTPA 467 + RGR+L GW +VM RK + + P A + + VE+ Sbjct: 452 VRRTVVEHQTFETRGRVLIESGWLQVMG--RKESNETLPPLASTAQDDSERAETVEIDLE 509 Query: 468 QHFTKPPARFSEASLVKELE----------------KRGIGRPSTYASII-STIQDRGYV 510 TK P R++EA+L+ +E RG+G P+T A+II I++R + Sbjct: 510 GKQTKAPPRYNEATLLSAMEGAGKLMEDDELREALQGRGLGTPATRAAIIEELIRNRYIL 569 Query: 511 RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF--- 567 R K ++ EL + T + E L Q+ + + + + H Sbjct: 570 RDARELIPTAKATTLLRLLRALKIDELTTAELTGEWEKKLKQIESDQFSSEEFMRHIRRM 629 Query: 568 FSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCG--------RKMGIRTASTGVFLGC 619 +D + + + D + ++ + ++ CP CG RK + ++ Sbjct: 630 TADIVEAARQCDVDQID-----DEYAVLAVPCPKCGQGRVRENYRKFVCESCDFSIWKSI 684 Query: 620 SGYALPPKERCKTTIN--LVPENEVLNVL------------------------EGEDAET 653 +G L P E + L P N + L +G+D + Sbjct: 685 AGRELSPNEVSSLLRDRRLGPLNGFRSRLGREFAAELMIKDDFTAAFDFGESTKGDDVDP 744 Query: 654 NALRAKRRCPKCGTAMDSYLIDPKRKLHVC----GNNPTCD 690 CPKCG + L P+R +VC G+ P CD Sbjct: 745 QTCDQVGPCPKCGAPV---LDAPRR--YVCRNGLGDEPACD 780 >UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NY48_9GAMM Length = 776 Score = 151 bits (381), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 181/672 (26%), Positives = 283/672 (42%), Gaps = 86/672 (12%) Query: 5 LVIVESPAKAKTINKYLGSD---YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 +VI E P+ A+ I + LG Y + ++ GHI L + A D T KK Sbjct: 4 VVIAEKPSMARAIREGLGPQANRYEITNAFGHI--LEQAEPDAYLPGDVPKTAKGKK--- 58 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEK--VVSELKQLAEKADHIYLATDLDREGEAI 119 + RM P A ++ P ++ ++++ L + AD + A D DREG+ + Sbjct: 59 ------IWRMQDLP--ILPAEWKKFPKRDAKDQLAKIGALLKSADTVINAGDPDREGQLL 110 Query: 120 A------WHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFM 171 +H R + RV + +R+AF + E +A +AR Sbjct: 111 IDEILEHFHYR-------GKVLRVWLKALDAENVRKAFAALESNEKYRPLKDAAEARSQS 163 Query: 172 DRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 D VVG ++ + K S GRVQ+ + +VV R+ EI+ FVP +++EV A G Sbjct: 164 DWVVGMNLTRAVTVKSGDLFSIGRVQTPTLAIVVRRDLEIENFVPRDYFEVFAQCRHTQG 223 Query: 232 EALALQVTHQNDKP-----FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFIT 286 LA D P R ++K + AV+ K V E K P+ Sbjct: 224 AFLAKWEPSSTDGPGFDEEGRLIDKRLAE-AVAQKAKGAGKVARFEAKEQKQSAPLPYSL 282 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV---NMVRGYISDNF 343 S LQ+ AS+R G ++ + Q LYE +Y RTD L ++ + + G + Sbjct: 283 SALQKVASSRFGMSAQQVLDTCQSLYEKKITSYPRTDCRYLPEEQLVDAPRILGKLPIPD 342 Query: 344 GKKYLPESPNQYASKENSQ-EAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQ 402 G + L ++ + N++ AH AI P+ A L D EA KLY LIWR +VA Sbjct: 343 GIRPLLNPRQKHVAWNNAKITAHNAIVPT--GEPARGLSDAEA---KLYDLIWRSYVALF 397 Query: 403 MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPA-LRKGDED-----RILPAVNKG 456 + +Y + + T+ G KA GR GW K+ A + DED LP + G Sbjct: 398 LPDYRYRALSATIALGGESWKATGRQDIDLGWKKLFGAQALEDDEDADGGKAPLPVMQTG 457 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYAS 499 D + TKPPARF++ SL+ + E G+G +T AS Sbjct: 458 DPVQGDGGKVEARQTKPPARFTDGSLIDAMSNIHKFVTDPQAKAKLKETSGLGTEATRAS 517 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLE-ENFRELMNYDFTAQMENSLDQVANHEA 558 ++ T+ R Y++ + ++ + G + LE + + TA+ E+ L V A Sbjct: 518 VLETLLQREYLQKKGKQLISTPKGRALIAYLEKQRLGSFADPVTTARWEDVLGMV----A 573 Query: 559 EWKAVLDHFFSDFTQQLDKA-----EKDPEEGGMRPNQMVLTSIDCPTCG-----RKMGI 608 E K + F + TQ++ KA GG +Q L + CP CG R++ Sbjct: 574 EGKVPMQKFTAAVTQEVAKAIEVLKSGSAMAGGGSSSQQPLRAQPCPICGGDAVVRRLQS 633 Query: 609 RTASTGVFLGCS 620 + F CS Sbjct: 634 KKNRKVFFWSCS 645 >UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DUF7_METI4 Length = 855 Score = 151 bits (381), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 154/569 (27%), Positives = 252/569 (44%), Gaps = 86/569 (15%) Query: 1 MGKALVIVESPAKAKTINKYLGS------------DYVVKSSVGHIRDLPTSGSAAKKSA 48 MGK LVI E P+ A+ I + LG ++ S+VGH+ +L + Sbjct: 1 MGKTLVIAEKPSVAQDIAEALGGFPKGRKDIYENDRMIISSAVGHVVELCLPAEMDSRHR 60 Query: 49 DSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYL 108 + + P + H E D I Sbjct: 61 QWSLSNLPILPSSFSLKPIQKHKDRLNLLLSLLH-----------------REDVDLIIN 103 Query: 109 ATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQ 166 A D REGE + +L + R+ +TK+AI +AF +P A Sbjct: 104 ACDAGREGELVFRYLIR-FAQVNKPIQRLWLQSMTKDAIIEAFKNLRPLREVEGLACAAV 162 Query: 167 ARRFMDRVVGYMVSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 +R D ++G + L K R S GRVQ+ + LVVER++EI +F P+ +WE Sbjct: 163 SRSESDWLIGINGTRALTALHSNSKGFRLTSVGRVQTPTLALVVERDKEILSFQPKPYWE 222 Query: 222 VDASTTTPSGEALA------LQVTHQNDKPFRPVNKEQTQAAVSLLEKA--RYSVLERED 273 + A+ + GE A Q +++ P R N++Q Q S++EK + ++ E Sbjct: 223 ILATFRSKQGEYKAKWFSRNSQHEGEDNHPERIENEDQCQ---SIIEKCLNKEGIVTEEK 279 Query: 274 KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAV 332 K + P + ++LQ+ A+ R GF ++T+ + Q LYE ITY RTDS L +D V Sbjct: 280 KVSQQSPPLLYDLTSLQREANNRFGFSAQRTLQIVQSLYENHKLITYPRTDSKFLPEDYV 339 Query: 333 NMVRGYISD-------NFGKKYLPESPNQYASK-ENSQEA--HEAIRPSDVNVMAESLKD 382 V+ + + F ++ L ++ Q A+K N+Q+ H AI P+ Sbjct: 340 PRVKEVLKNLSHGPFETFAREILSQNWVQPANKIFNNQKVSDHFAIIPT-----THKPTT 394 Query: 383 MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM---- 438 + A+ +K+YQLI R+F+A PA+++ T + + G+IL+ GW KV Sbjct: 395 LNANEEKIYQLIVRRFLATFYPPAQWEITKRITVVEEESFRTEGKILKSAGWLKVYRDSN 454 Query: 439 PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------- 487 PA + E+ +L + +G+ + + + TKPPA F+EA+L+ +E Sbjct: 455 PA--QNTEEDVLCPIEQGEKVLNLAMEKIAKETKPPAHFTEATLLSAMESAGKLVEDETL 512 Query: 488 -----KRGIGRPSTYASIISTIQDRGYVR 511 K+G+G P+T A II + + GY+R Sbjct: 513 REAMAKKGLGTPATRAGIIEGLIEDGYIR 541 >UniRef50_Q181Z2 DNA topoisomerase n=23 Tax=Clostridium RepID=Q181Z2_CLOD6 Length = 742 Score = 150 bits (380), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 161/624 (25%), Positives = 279/624 (44%), Gaps = 83/624 (13%) Query: 5 LVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 LV+ E P+ AKTI +LG+ DY++ +VGH+ S Sbjct: 3 LVLAEKPSVAKTIASFLGAKTRQDGYFEGNDYIITYAVGHL----------------VSL 46 Query: 54 KTAKKPKKDERGAL--VNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYL--A 109 K KD+ +N P ++ +++ K K + +K+L + D Y+ A Sbjct: 47 YDMKDYDKDKYSGSWKMNNFPFVPEDKFK--FKIDSSKTKQFNTVKKLLNRKDVEYVINA 104 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAF-NKPGELNIDRVNAQQAR 168 TD DREGE IA+ L ++ + R++ NE T I + N E + + A Sbjct: 105 TDNDREGELIAF-LIFLLAKNKKPVKRILVNEWTPEDITRGIKNLKDEDEMRNLQAAGYT 163 Query: 169 RFM-DRVVGYMVSPLLWKKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 R + D ++G + + K G L+ GRV V+LV +R+ EI FVP+ ++E++ Sbjct: 164 RLITDWLIGINFTSVATLKYGNGKLLNIGRVILPTVKLVYDRDMEILNFVPKTYYEIEGH 223 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP-- 283 +GE V + K F + E ++ + +L++ K T SK AP Sbjct: 224 FKAEAGEYKGKYVKGKESK-FDTL--EDANKIIASITSETGKILDK--KVTMSKEYAPKL 278 Query: 284 FITSTLQQAASTRL-GFGVKKTMMMAQRLYEA----GYITYMRTDSTNLSQDAVNMVRGY 338 F ++LQ +++ F K + + Q LYE GYITY RTDS L + + Sbjct: 279 FSLTSLQGYITSKYSNFTSDKVLNVCQSLYEGNGKGGYITYPRTDSIFLEESLASKASQT 338 Query: 339 ISD-NFGKKY---LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 + G +Y + S + + ++H AI P+ + K + D Q +Y I Sbjct: 339 LDKLKVGLEYENKIKFSKTKRVFDSSKVDSHSAIIPTYI-----IPKSLSKDEQLVYDAI 393 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVN 454 +FVA M PA+Y++T + + +G++L+ G+ +V K D +LP VN Sbjct: 394 KDRFVANFMPPAEYENTEIKTEVDNCTFLTKGKVLKSKGYLEVYNKEEKND---LLPLVN 450 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELEKRG---------------IGRPSTYAS 499 K D + ++E+ P T PP ++E +L+K ++ G IG +T A Sbjct: 451 KDDVVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCGKNVPEEDTTVLSGYSIGTSATRAD 510 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENF--RELMNYDFTAQMENSLDQVANHE 557 ++ I GYV+ + + + ++G+ L E F ++L + D+T ++E SL + + Sbjct: 511 VLKKISQVGYVKKKGKSYSITELGK----NLVEIFPVKDLFDVDYTGKLEKSLSDIQKGK 566 Query: 558 AEWKAVLDHFFSDFTQQLDKAEKD 581 K L + S Q ++ ++D Sbjct: 567 YTRKEYLTNIISFIYQNVNIIKQD 590 >UniRef50_Q9HM08 DNA topoisomerase 1 n=4 Tax=Thermoplasmatales RepID=TOP1_THEAC Length = 770 Score = 150 bits (378), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 174/696 (25%), Positives = 290/696 (41%), Gaps = 98/696 (14%) Query: 96 LKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG 155 L+ K + I +ATD DREGE I ++I R F+ +TKN I +F Sbjct: 94 LQAFRGKVEEIVIATDYDREGELIGVEALDIIKEGKEEIRRAKFSALTKNEILDSFKNLI 153 Query: 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIAR----GLSAGRVQSVAVRLVVEREREI 211 +N +A AR +D + G +++ R LSAGRVQ+ + +VV+REREI Sbjct: 154 GVNYSLADAADARESIDLIWGSVLTRFFSVTTGRLGKSFLSAGRVQTPTLAIVVDREREI 213 Query: 212 KAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFR---PVNKEQTQAAVSLLEKAR--- 265 ++F PE +W + +T D F+ P N + A + E + Sbjct: 214 QSFRPERYW--------------TISITFDKDGQFKARYPENIKDQDTAEKIYEAIKGKN 259 Query: 266 ---YSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRT 322 S +ED +P APF T+ + AS R+G K M +A+ LY G I+Y RT Sbjct: 260 GRVSSYTSKEDH--IRRP-APFSTTEFLREAS-RIGIMPTKAMSIAENLYMRGLISYPRT 315 Query: 323 DSTNLSQDAVNM--VRGYISDNFGKKYLPE--SPNQYASKENSQEA--HEAIRPSDVNVM 376 D+T + ++N+ V + + KY+ E + ++ E H I P V+ Sbjct: 316 DNTVYPR-SINLKSVLKKLENTAYSKYVKEIETFDRILPSRGRIETTDHPPIYP--VDSP 372 Query: 377 AESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTK 436 E LK D ++Y LI R F++ K + + KA G+ GWT+ Sbjct: 373 KEQLK---GDYGRVYDLILRHFLSTLYRDGKKTVAEAEIYVNGYTFKAAGQHTTDRGWTE 429 Query: 437 VMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPST 496 + K D LP + +G+ L ++ + TKPP R+ +SL+K++E+ +G ST Sbjct: 430 IYGYDPK---DVYLPELTEGEDLKAIDWNIQREETKPPPRYDMSSLLKKMEELNLGTKST 486 Query: 497 YASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 II + +RG+ +E +G D + + + + TA++E +D++ + Sbjct: 487 RHDIIGKLIERGF--IEGNPVKPTPLGMAFIDAVRSVNSHIADPEMTAKLEEDMDRIEKN 544 Query: 557 EA-------EWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTC-GRKMGI 608 E E K +L S F + KD G+ Q + DCP G+K+ + Sbjct: 545 EMSKNDVVEESKKMLHEVLSHFLTKTADV-KDIITKGINAGQEIG---DCPFHEGKKIMV 600 Query: 609 RTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 + C + CK + + + ++CP CG Sbjct: 601 IRDRFTYTVRCEDPS------CKINFRIKRNGSI-------------TLSDQKCPVCGLP 641 Query: 669 MDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK- 727 M +I + + +P C Y E ++ EC + L+ ++GK Sbjct: 642 MIK-IIRKGQSPEIKCIDPDC-SYNRENEDYG---------ECPADHGRLVLRQSKYGKR 690 Query: 728 YMACTN-EECKNTR------KILRNGEVAPPKEDPV 756 ++ C+N +C T +I + GEV P P+ Sbjct: 691 FLGCSNYPKCTVTYPLPQMGRITKTGEVCPYCGAPI 726 >UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8VXL1_DESAS Length = 746 Score = 149 bits (377), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 175/706 (24%), Positives = 301/706 (42%), Gaps = 139/706 (19%) Query: 3 KALVIVESPAKAKTI----------NKYLGSD-YVVKSSVGHIRDL--PTSGSAAKKSAD 49 K LV+ E P+ A+ + N YL SD Y++ ++GH+ L P AA K Sbjct: 2 KQLVLAEKPSVARDLSNVLGNFNKGNGYLESDAYIITWAIGHLVTLAEPDDYDAALKKW- 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIY 107 +N + + P E + + K + +K L + D I Sbjct: 61 -----------------FLNTLPILPR---EFKLKPVSATLKQFNIVKSLLHRNDVGDII 100 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVN-A 164 ATD REGE I ++ ++ + R+ +E T A+R+ F+ +PG ++DR+ A Sbjct: 101 CATDSGREGELIFRYIYKLTDCQKP-FKRLWLSETTPAAVRKGFDNLRPGN-DLDRLAFA 158 Query: 165 QQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 +AR D ++G + K + LS GRVQ+ + L+V RE+EI+AFVPE++WE+ A Sbjct: 159 AEARSQADWLIGINATRAFTVKHNQLLSVGRVQTPTLALIVNREQEIRAFVPEKYWELFA 218 Query: 225 STTTPSGEA-----------------LALQV----THQN--------------------- 242 T +G+ + +QV T+QN Sbjct: 219 LFTKENGQTYIGKWFKKEKKAVENWEIPIQVGQKQTNQNPAASFEAAQGGIPSVMGEAVP 278 Query: 243 -----DKPFRPVNKEQTQAAVSLLEKARY----SVLEREDKPTTSKPGAPFITSTLQQAA 293 DKP K + A ++K V+ E K P F + LQ+ A Sbjct: 279 SSNGQDKPVAMQTKFAAREAARDIQKKVTGQPGQVVSVEKKDIIEHPPLLFNLNDLQKEA 338 Query: 294 STRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQD----------AVNMVRGYISDN 342 + + G KT+ +AQ LYE+ ITY RTDS ++ + A+ +V Y +N Sbjct: 339 NKKFGLSAAKTLSVAQELYESRKLITYPRTDSRCITVEMGKTIPQRLGALAVVAEY--EN 396 Query: 343 FGKKYLPESPNQYASKENSQEA----HEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 F +L + + +K ++ H A+ P++V L + +D +++Y L+ R+F Sbjct: 397 F--IHLIKERKAFLNKRYINDSKVTDHTALIPTNVK---PDLDKLSSDERRVYDLVVRRF 451 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRK---GDEDRILPAVNK 455 +A PA+Y+ T + +RGR+ GW V ++ DE ILP + Sbjct: 452 LAAFFPPARYEQTQVITEVKQETFLSRGRVELDKGWKTVYDPVQDKLVDDEQGILPVIEN 511 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRPSTYAS 499 +++ + + T PP R++EA+L+ +E G+G P+T A+ Sbjct: 512 EESVLTTKTDIKEKKTNPPKRYTEAALLSVMEGAGRLLNDEELKEAMRGSGLGTPATRAA 571 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 II + GY+ + + GE + + E + + + TA+ E +L + + + Sbjct: 572 IIERLLKVGYIERRKKTLLPTEKGENLIKLVPEQVK---SPEMTARWEKALADIEDGQLN 628 Query: 560 WKAVLDHFFSDFTQQLDKAEKDPEEG-GMRPNQMVLTSIDCPTCGR 604 + Q ++ A + EG +R N+ ++ CP CGR Sbjct: 629 PGEFMSGIIEQTRQVVELARRQKTEGEPLRNNRDIIGK--CPLCGR 672 >UniRef50_Q9YCB6 Topoisomerase n=1 Tax=Aeropyrum pernix RepID=RGYR1_AERPE Length = 1370 Score = 149 bits (377), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 184/708 (25%), Positives = 287/708 (40%), Gaps = 174/708 (24%) Query: 4 ALVIVESPAKAKTINKYLGSDYV--------------------VKSSVGHI--------- 34 AL++VESP KA+TI ++ G V + +S GH+ Sbjct: 648 ALLVVESPNKARTIARFFGQPSVRLLPGGGRVYEVATGDKILMIMASGGHVFDLVVRVDG 707 Query: 35 RDLPTSGS--------------AAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWE 80 RDL +G +A T T+ K D V+ P Sbjct: 708 RDLEAAGGEPEHAIFGVLRYRLGGNGAAAYTPVYTSIKRCLDCGYQFVDEASRCP----R 763 Query: 81 AHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFN 140 E++ V +L+++A +AD +Y+ TD D EGE I W + + R+ F+ Sbjct: 764 CGSELIRNSLSTVEDLRRVAWEADEVYVGTDPDTEGEKIGWDVALALRPYAPDIKRLEFH 823 Query: 141 EITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW---------------- 184 E+TK AI +A + P + + V+AQ RR DR +G+ +SPLLW Sbjct: 824 EVTKKAILEALSNPRSFDDNLVDAQVVRRVEDRWIGFTLSPLLWCDFWPRYCKRVLEEYG 883 Query: 185 -------------KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 K LSAGRVQ+ + VV+R + ++ W + Sbjct: 884 EKRPHMDRERCAKYKAYYNLSAGRVQTPTLGWVVDRTLAYR----KKVWLYRVVHDS--- 936 Query: 232 EALALQVTHQNDKPFRPVN---------KEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 L ++D P P + K + + + +V+E+E+ T P Sbjct: 937 ---QLLFAVRSDDPEVPESVKRVLDNWVKHHKKTGIEPWLDVK-AVVEKEEW-TALPPPP 991 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDN 342 P+ T T+ + A+ LG G + M +AQ L+E G ITY RTDST +S + + R ++ Sbjct: 992 PYTTDTMLRDANRLLGLGSAEAMRIAQDLFEWGLITYHRTDSTRVSDRGMQVAREWLETR 1051 Query: 343 F----GKKYLPESPNQYASKENSQEAHEAIRPSDVN----VMAESLKDMEADAQ----KL 390 F G+ Y P + + EA +RP DV ++ E + ++ +L Sbjct: 1052 FGGLAGQLYRPRRWGE----GGAHEAIRPVRPIDVERLQLLVEEGVIELPGTLTRRHLRL 1107 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWT----KVMPALRKGDE 446 Y LI+R+F+A QM A R+ R R+ DG+T +V+ R GD Sbjct: 1108 YDLIFRRFMASQMREAD-----------ALRVVYRLRVPELDGYTLTLERVVEIGRPGDA 1156 Query: 447 DRILPAVNKGDALT---------LVELTPAQHFTKPPAR-------FSEASLVKELEKRG 490 + V +G L LVE A + R ++E +V+E++ RG Sbjct: 1157 E----GVTRGFTLVWPYVRPQPRLVEGREAWIRARVEGRQVPKAYPYTEGEIVEEMKTRG 1212 Query: 491 IGRPSTYASIISTIQDRGYV----RVENRR---FYAEKMGEIVTDRLEENFR-------- 535 IGRPSTYA I+ T+ R YV R E R A G V + L E R Sbjct: 1213 IGRPSTYAKIVETLFRRRYVIEVSREEGRGAGFVVATSRGINVYNYLTEELRSADEEEYG 1272 Query: 536 -----------ELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 L++ D T ++E +D V +A VL+ F++ + Sbjct: 1273 GRIAGILRRVPSLVSEDRTRELERQMDMVEKGDASRDDVLESVFNEIS 1320 >UniRef50_B1SE14 DNA topoisomerase n=1 Tax=Streptococcus infantarius subsp. infantarius ATCC BAA-102 RepID=B1SE14_9STRE Length = 578 Score = 149 bits (375), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 151/556 (27%), Positives = 254/556 (45%), Gaps = 66/556 (11%) Query: 65 GALVNRMG-VDPWHNWEAH--------YEVLPGKEKV--VSELKQLAEKADHIYLATDLD 113 G LV R+ + NWE + P K+ + + +K+ ++ D I + TD D Sbjct: 48 GHLVERINPYSNFENWEMTNLPALPEGFSYEPKKDTIKRFNAIKKAVKEVDAIIIGTDPD 107 Query: 114 REGEAIAWHLREVIGGDDARYS-RVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRF 170 REGEAIA+ + E+I G + R+ N +TK + QA++ K + ++D + AR Sbjct: 108 REGEAIAYRILELIPGALKKIKYRLWANSLTKKGLEQAYSSLKNPKDSVDYFHEADARGD 167 Query: 171 MDRVVGYMVSPLLWKKIA---------RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 D +VG+ +SP + K+ +S GRVQ+ V LVV + I+ F P +W+ Sbjct: 168 ADWLVGFNLSPFVTIKMKEEGYLDKKEHSMSVGRVQTPIVSLVVRNDEAIENFKPSPYWQ 227 Query: 222 VDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 + P +VT ND ++ E Q L A + E+K Sbjct: 228 L--KLIDPEA-----KVTFGNDIKYQS-KSEAEQILQQLTNTAVVKTVTSEEKAQE---- 275 Query: 282 AP--FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYI 339 AP + + Q S F KT + Q LY+ GY++Y RTDST ++ Y+ Sbjct: 276 APKLYNLTNFQSEMSKLYHFDATKTKELVQSLYQKGYLSYPRTDSTLITTKEF----AYL 331 Query: 340 SDNFGK------KYLPESPNQYASKENSQEA----HEAIRPSDVNVMAESLKDMEADAQK 389 D+ K K L E+PN+ K + H AI P++ L ++ D + Sbjct: 332 VDHIEKYQKAINKQL-ETPNRSPRKSYVNDKKVVEHYAIIPTET---IPDLNELSDDEKL 387 Query: 390 LYQ-LIWRQFVACQMTP-AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED 447 +YQ +++R + TP +Y ST++ + KA G + + GW + ED Sbjct: 388 IYQKVVFRTLL--MFTPDYRYQSTSVILDNHGLEFKATGAVTKDKGWRNYFSVKK---ED 442 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKE-LEKRGIGRPSTYASIISTIQD 506 + LP +G +T VE + TKPP R +E L+K+ L K +G +T +I IQD Sbjct: 443 KELPHYQEGQKIT-VECKVLEEVTKPPTRITEQILLKKLLPKYHLGTSATRDGMIDLIQD 501 Query: 507 RGYVRVENR--RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 +GYV + +F+ + G+++ L++ N + T + E L Q+ + + +A + Sbjct: 502 KGYVTKNKKTGQFFPTERGKLLIHYLDQLEIAYTNPETTGKWEEVLAQIGQGKIQKEAFV 561 Query: 565 DHFFSDFTQQLDKAEK 580 D T+Q++K ++ Sbjct: 562 DKIKWAITKQIEKGKQ 577 >UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=A4JTK7_BURVG Length = 893 Score = 148 bits (374), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 218/879 (24%), Positives = 354/879 (40%), Gaps = 164/879 (18%) Query: 1 MGKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSAD 49 MGK L+I E P+ AK I LG D ++ S+ GH+ ++ ++ S Sbjct: 1 MGKTLIIAEKPSVAKDIALALGGFGRVDNWLESPDAIISSAQGHLVEVFST--LMDTSGK 58 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPG--KEKVVSELKQLAEK--ADH 105 + P D R V+ G + ++ ++LK+L + D Sbjct: 59 DLQSLPVIPPSFDLR--------------------VIDGANRPQLFAQLKRLMSRQDVDA 98 Query: 106 IYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVN 163 + A D REGE I + L + G R+ F +T AIR++F+ KPG + Sbjct: 99 VVNACDAGREGELI-FRLIYKLAGCTKPMKRMWFRSMTPEAIRESFHSMKPGADFDGLSD 157 Query: 164 AQQARRFMDRVVGYM----VSPLLWKKIA--RGLSAGRVQSVAVRLVVEREREIKAFVPE 217 A R D +VG V+ L ++ A S GRVQ+ LV +RE I+ F + Sbjct: 158 AAFCRTEGDYLVGINGSRGVTRLYERQTASVENRSVGRVQTPTGALVYDREMAIRTFRAK 217 Query: 218 EFWEVDAS---------------TTTPSGEALALQVTHQNDKPFRPVN----KEQTQAAV 258 ++WEV SGE L + K N K++ A V Sbjct: 218 DYWEVHGHFGVAAGNYVGKWFDPNFKASGEQQELGEGGGSGKSDETANRFFEKDRADAIV 277 Query: 259 SLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI- 317 + + + E KPT + ++LQ+ A+ +LG K+T+ +AQ LYE + Sbjct: 278 AKCSGTNPTDVREESKPTAKGSPRLYDLTSLQREANRKLGLSSKRTLDIAQALYEKHKVT 337 Query: 318 TYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES----------PNQYASKENSQEAHEA 367 TY RTDS+ L +D V + I G Y P + P++ H A Sbjct: 338 TYPRTDSSFLPEDYVAKAQSTIESLVGTTYEPHAKRVIDGGWVKPDKKIFDNGKISDHFA 397 Query: 368 IRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT-LTVGAGDFRLKARG 426 I P+ + + + + K+Y +I R+F+A A+Y TT +TV AG+ K+ G Sbjct: 398 IIPT-----GKRPEGLTPEEGKVYDMIVRRFLAVFHPAAQYQVTTRITVVAGE-HFKSSG 451 Query: 427 RILRFDGWTKVMPALRKGDEDRILPAVNK---GDALTLVELTPAQHFTKPPARFSEASLV 483 R+L +GW V A DED+ PA+ K G+A+T V + TKPP R++E +L+ Sbjct: 452 RVLISEGWMAVYGA-DVDDEDKKTPALVKYEAGEAVTTVRIELKTLKTKPPLRYTEDTLL 510 Query: 484 KELE----------------KRGIGRPSTYASIISTI----QDRG-----YVRVENRRFY 518 +E +RG+G P+T A+II + +G Y++ + + Sbjct: 511 AAMESAGKFVDDDELADAMKERGLGTPATRAAIIEGLLADKDGKGNPKEPYLKRDGKSLV 570 Query: 519 AEKMGEIVTDRLEENFRELM-NYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 + + L N EL+ + T + E+ L + E A ++ D T+Q+ Sbjct: 571 PTPKLISLIEFLRNNGIELLASPKLTGEWEHKLRLIERGEYRRDA-FNNEIGDLTRQIID 629 Query: 578 AEKDPEEGGMRPNQMVLTSID--CPTCGRK--MGIRT----------------------- 610 A + + ++V+ +D CP CG + +G RT Sbjct: 630 AIRK------KAAEVVVKKLDAKCPQCGGEIAIGARTFDCESACGFRLWKEIAGRQLKPS 683 Query: 611 -----ASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKC 665 +T V + + + K++ + L E++V + T+A CP C Sbjct: 684 EANTLLTTRVVMNLNNFISNSKKKFTACLRLNDEHKVEFFFDETVNTTDASGNPVHCPVC 743 Query: 666 GTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE---CEKCGSEMHLKM 722 M + C + C + G P V C KC S+M+ Sbjct: 744 EKLM-RRISGANGHFWSCTDRENCKTTLDDSA-----GNPVPKVAAQPCPKCSSDMNRVR 797 Query: 723 GRFGKYMACTNEE-CKNTRKILRNGEVAPPKEDPVPLPE 760 G+ G + +CT+ E CKNT V P DP+ P+ Sbjct: 798 GKKGYFWSCTDREGCKNTMDDKDGAPVTRP--DPIACPD 834 >UniRef50_A3DP02 DNA topoisomerase n=9 Tax=Desulfurococcaceae RepID=A3DP02_STAMF Length = 723 Score = 148 bits (374), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 150/580 (25%), Positives = 257/580 (44%), Gaps = 55/580 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVG----HIRDLPTSGSAAKKSADSTSTKTA 56 +GK +VI E P A I L + + KS G I++ +S A + T Sbjct: 52 IGKIVVIAEKPKAANKIALALSRNPIRKSMYGIPYYLIKNRHSSIIVASAAGHLYGLHT- 110 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHYEVLP---GKEKVVSELKQLAEKADHIYLATDLD 113 D+ G V + + W+ Y++ P EK + L +L AD+ A D D Sbjct: 111 -----DQYGYPVFK------YEWKPLYQIDPKAKHTEKFIMVLSKLCSNADYYVNACDYD 159 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 EG I +L GD + R F+ +T +R++F K L+ + + A R +D Sbjct: 160 IEGSVIG-YLIIYFHGDLEKSLRAKFSSLTIEELRESFRKLTSLDWEMIEAGLCRHELDW 218 Query: 174 VVGYMVSPLLWK--KIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 + G +S L KIA G LSAGRVQ+ +R VVE++ E + F+P + + + Sbjct: 219 IWGINISRALMSSVKIASGKRVILSAGRVQTPTLRYVVEKDIERRLFIPLPQYSLSINIF 278 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLER-EDKPTTSKPGAPFIT 286 + E H K K+ + + +++ Y ++++ E+K T P F Sbjct: 279 KNNYE------IHVEYKGKSVETKKNAKEIIDEIKRTGYLIVKKYEEKIYTLNPPPAFNL 332 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLS--------QDAVNMVRGY 338 LQ+ A+ GF KT +A++LY I+Y RT+S L + ++ + Y Sbjct: 333 GDLQEEAARIYGFSPYKTQSIAEKLYLDALISYPRTNSQKLPPTLNYKAIMNKLSRINNY 392 Query: 339 ISDNFGKKYLPESPNQYASKENSQE--AHEAIRPSDVNVMAESLKDMEADAQKLYQLIWR 396 L E+ + S++ AH AI P+ V KD+ D K+Y LI R Sbjct: 393 --KELVSNLLVETKGVLKPVQGSKDDPAHPAIYPTGVKP-----KDLGKDEWKIYDLIVR 445 Query: 397 QFVACQMTPAKYDSTTLTVGAG---DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAV 453 +F+A + A+ + + +A G+ + GW + P + E+R LP Sbjct: 446 RFLAAFASKARISHRIVYLEYPKDPSMVFQASGQKILDLGWLRYYPFSK--PEERFLPKF 503 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513 G+ + +V+ + + +TKPP + ++ +++ +E GIG +T A II + R Y+R Sbjct: 504 QYGEKVKIVKASIRKTYTKPPEKINKIKILRWMENVGIGTEATRARIIEILFSRYYLRSV 563 Query: 514 NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQV 553 R A +G + + L E F E+ + T E ++++ Sbjct: 564 GGRVEATDLGLGIIEVLMEYFPEITSVSLTRHFEEEMEKI 603 >UniRef50_Q1J4U0 DNA topoisomerase n=30 Tax=Bacteria RepID=Q1J4U0_STRPF Length = 577 Score = 148 bits (373), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 158/573 (27%), Positives = 249/573 (43%), Gaps = 90/573 (15%) Query: 5 LVIVESPAKAKTINK-----------YLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 LVI E P+ A TI K Y G+ Y+V VGH+ Sbjct: 7 LVIAEKPSVAVTIAKIIGARTRKNGYYEGNGYIVSWCVGHL------------------I 48 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNW----------EAHYEVLPGKEKVVSELKQLA-EK 102 + A K DE+ W W E YEV +K LK+L +K Sbjct: 49 QMASPDKIDEK-----------WKKWTIENLPIIPEEYIYEVSKSTKKQYGVLKKLLNDK 97 Query: 103 ADHIYL-ATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNI 159 +I + A D REGE I + L + R+ + + AI F K GE Sbjct: 98 NINIVINACDAGREGELI-FRLVYNQAKCKKKIQRLWISSMENEAIEDGFRNLKDGEKFE 156 Query: 160 DRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEF 219 D + AR D +VG +S L S GRVQ+ + L+ +R+ EI F +++ Sbjct: 157 DLYRSASARAIADWLVGMNLSRLYSCIYKETYSVGRVQTPTLYLIAKRDSEINLFKKQKY 216 Query: 220 WEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSK 279 + VD S L L V+ + D+ E + ++LLE + E EDK ++K Sbjct: 217 YTVDLSYG-----GLKL-VSDRIDRI------EVAEQLLNLLED-EIVITEVEDKEVSTK 263 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYI 339 P P+ +TLQ+ A+ G+ T+ +AQ LYE ITY RTDS L+ D VN ++ + Sbjct: 264 PDKPYDLTTLQREANKYFGYSANDTLNLAQALYEKKLITYPRTDSRYLTDDMVNTMKELL 323 Query: 340 SDNFGKKYLPESPNQYASKENSQEA--HEAIRPSDVNV-MAESLKDMEADAQKLYQLIWR 396 + + + N + S NS + H AI P+ + A+ L D E+ K+Y LI Sbjct: 324 -EGLEEDFKLNKSN-FKSIFNSSKVTDHYAIIPTISGIGKAKDLSDKES---KVYNLIKD 378 Query: 397 QFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKG 456 + +A K S + F A G+ + +G+TK + A K ++ LP V G Sbjct: 379 KLLASCSDNLKESSRKIRYEYDKFNFNASGKTIIDEGYTKYLKAYGKEKQENELPDVKTG 438 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVK--------------ELEKRGIGRPSTYASIIS 502 D + L ++ FTK P+ ++E +L+K E+E++G+G P+T A II Sbjct: 439 DKIKLTSKNISEKFTKAPSHYNEDTLLKAMENAGVESLDKDIEVERKGLGTPATRAGIIE 498 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFR 535 + + +R + + + G + +E+ F+ Sbjct: 499 NLIHKELIRRDKKNLLVTEKGNRLVSIVEDKFK 531 >UniRef50_O95985 DNA topoisomerase 3-beta-1 n=72 Tax=Eukaryota RepID=TOP3B_HUMAN Length = 862 Score = 148 bits (373), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 141/514 (27%), Positives = 231/514 (44%), Gaps = 42/514 (8%) Query: 89 KEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVI--------GGDDARYSRVVFN 140 K +V L+ D+I L D D+EGE I + + + + GG+ + R F+ Sbjct: 95 KLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVF-RARFS 153 Query: 141 EITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI--------ARGLS 192 IT I A GE + + + AR+ +D +G + K + +S Sbjct: 154 SITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLIS 213 Query: 193 AGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKE 252 G Q+ + VER +I++F PE +W + A T +L L R ++E Sbjct: 214 FGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDR-----VRVFDRE 268 Query: 253 QTQAAVSL--LEK-ARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQ 309 Q +++ LEK A+ R++K +P A T + + AS+ LG G + M A+ Sbjct: 269 IAQMFLNMTKLEKEAQVEATSRKEK-AKQRPLA-LNTVEMLRVASSSLGMGPQHAMQTAE 326 Query: 310 RLYEAGYITYMRTDSTNLSQ--DAVNMVRG-----YISDNFGKKYLPESPNQYASKENSQ 362 RLY GYI+Y RT++T+ + D +R Y +D K+ L E N+ K + Sbjct: 327 RLYTQGYISYPRTETTHYPENFDLKGSLRQQANHPYWADTV-KRLLAEGINR-PRKGHDA 384 Query: 363 EAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRL 422 H I P AE + DA +LY+ I R F+A KY +T++ G Sbjct: 385 GDHPPITPMKSATEAE----LGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELF 440 Query: 423 KARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASL 482 G+ + G+T+VMP E+ LP +GDA + E+ + T PP +EA L Sbjct: 441 TCSGKTVLSPGFTEVMPWQSVPLEES-LPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAEL 499 Query: 483 VKELEKRGIGRPSTYASIISTIQDRGYVRVEN-RRFYAEKMGEIVTDRLEENFRELMNYD 541 + +EK GIG ++ I+ I R YV VE+ RR +G ++ + EL+ Sbjct: 500 ITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYYKIDAELVLPT 559 Query: 542 FTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 + +E L+ +A +A+++ VL H F ++ Sbjct: 560 IRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKF 593 >UniRef50_Q13472 DNA topoisomerase 3-alpha n=31 Tax=Eumetazoa RepID=TOP3A_HUMAN Length = 1001 Score = 147 bits (372), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 154/609 (25%), Positives = 249/609 (40%), Gaps = 72/609 (11%) Query: 96 LKQLAEKADHIYLATDLDREGEAIAWHLREVIGG--DDARYSRVVFNEITKNAIRQAFNK 153 L++ + + + TD DREGE I + + V + + R F+EIT +A+R A Sbjct: 133 LERETRQCQALVIWTDCDREGENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACEN 192 Query: 154 PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIAR---------GLSAGRVQSVAVRLV 204 E + +A R+ +D +G + ++ R +S G Q + V Sbjct: 193 LTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFV 252 Query: 205 VEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSL-LEK 263 VER + I+AFVPE F + + G + N K R N L +E Sbjct: 253 VERFKAIQAFVPEIFHRIKVTHDHKDG------IVEFNWKRHRLFNHTACLVLYQLCVED 306 Query: 264 ARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTD 323 +V+E KP + T L++ AS +L K+TM +A++LY GYI+Y RT+ Sbjct: 307 PMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTE 366 Query: 324 STNLSQD--AVNMVRGYISD----NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMA 377 + +D +V D F + L + S +AH I P+ Sbjct: 367 TNIFPRDLNLTVLVEQQTPDPRWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYT--- 423 Query: 378 ESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKV 437 +++ D Q+LY+ I R F+AC A+ TT+ + R A G ++ + V Sbjct: 424 ---NNLQGDEQRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDV 480 Query: 438 MPALRKGDEDRILPAVNKGDAL--TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPS 495 P D+ILP +G + VE+ + T PP +EA L+ +EK GIG + Sbjct: 481 YPY--DHWSDKILPVYEQGSHFQPSTVEMVDGE--TSPPKLLTEADLIALMEKHGIGTDA 536 Query: 496 TYASIISTIQDRGYVRVE-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 T+A I TI+ R YV + ++RF +G + + + E+ D A++E L + Sbjct: 537 THAEHIETIKARMYVGLTPDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLIC 596 Query: 555 NHEAEWKAVLDHFFSDFTQ----------QLDKAEKDPEEGGMRPNQ-------MVLTSI 597 + + + VL + Q +LD+A G Q M Sbjct: 597 DGKKDKFVVLRQQVQKYKQVFIEAVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIR 656 Query: 598 DCPTCGRKMGIRTASTGVF-LGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNAL 656 CP C + M ++T G F L C G+ C++ + L D+ A Sbjct: 657 KCPQCNKDMVLKTKKNGGFYLSCMGFP-----ECRSAVWL------------PDSVLEAS 699 Query: 657 RAKRRCPKC 665 R CP C Sbjct: 700 RDSSVCPVC 708 >UniRef50_C9BSW4 DNA topoisomerase n=54 Tax=Lactobacillales RepID=C9BSW4_ENTFC Length = 801 Score = 147 bits (372), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 148/568 (26%), Positives = 242/568 (42%), Gaps = 52/568 (9%) Query: 83 YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH-LREVIG-GDDARYSRVVFN 140 YEV K S +K+ + AD I +ATD DREGEAIAW +R+ + Y R+ N Sbjct: 139 YEVPMDKRAQFSIVKRELQSADTIIIATDGDREGEAIAWSIIRQANAFSKEKNYLRLWIN 198 Query: 141 EITKNAIRQAFN--KPGELNIDRVNAQQARRFMDRVVGYMVSPLLW-----KKIARGLSA 193 + K AI + F +PG+ + QAR+ D ++G SPL K I S Sbjct: 199 SLEKEAIYEGFKNLQPGKNYFPKYKEAQARQNADWLIGMNGSPLYSLLLQRKGIDGSFSL 258 Query: 194 GRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQ 253 GRVQ+ + ++ + + EIK F E ++E + TT G+ V + K + KE Sbjct: 259 GRVQTPTLYMIYQLQEEIKHFKKETYFEGEGLITTNKGQFSGKIVPKKAFKTQEELTKEI 318 Query: 254 TQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE 313 + L K +LE K F S+LQ + + K T+ AQ LYE Sbjct: 319 EKLGAH-LGKQNGRILEVTKKEKRLHSPRLFSLSSLQTKMNQLMKASAKATLDAAQGLYE 377 Query: 314 AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP---------ESPNQYASKENSQEA 364 + +++Y RTDS ++++ + ++ + KK+L ++ +Y + QE Sbjct: 378 SKFLSYPRTDSFYITENEHQYLVKHLQNY--KKFLGIEEVQTTEIKAKKRYVDAKKVQE- 434 Query: 365 HEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKA 424 H AI P+ + Q +Y + R VA Y+ TT+ G +LK+ Sbjct: 435 HHAIIPTKTIPTPARFAKLSKLQQAIYLQVLRTTVAMFAADYIYEETTVMTGVQQLKLKS 494 Query: 425 RGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVK 484 G+I GW +++ K E + LP + + + VEL + T+PP ++E +L+ Sbjct: 495 IGKIPLQQGWQEILRIKSKKKEAQTLPPIVENEEAE-VELKSMEKETQPPKPYTEGTLIT 553 Query: 485 EL-----------------EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 + E GIG +T A+II ++ + Y+ V G I Sbjct: 554 AMKTAGKTLDNDEAQEILKEVEGIGTEATRANIIENLKQKHYIEVNKNEITVTPKG-ITL 612 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD-------HFFSDFTQQLDKAEK 580 + N L + + TA+ E L ++ E L+ H ++ Q+DK + Sbjct: 613 CKAVANEPLLTSAEMTARWEGYLRKIGKQEGTPSVFLENIKKFILHLLAEVPNQIDKVDF 672 Query: 581 DPEEGGMRPNQMVLTSID----CPTCGR 604 E G R + + D CP C + Sbjct: 673 SDEISGTRQIKAMEKKNDQLGRCPKCKK 700 >UniRef50_C1DYX0 Predicted protein n=4 Tax=Viridiplantae RepID=C1DYX0_9CHLO Length = 861 Score = 147 bits (371), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 174/693 (25%), Positives = 282/693 (40%), Gaps = 95/693 (13%) Query: 89 KEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG------DDARYSRVVFNEI 142 K +VV L++ A+ A H+ L D DREGE I + + + D R F+ + Sbjct: 93 KARVVEHLEREAKGASHLILWLDCDREGENICFEVIDACAPVMRPNRGDTFVHRAKFSAV 152 Query: 143 TKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI--------ARGLSAG 194 +K +I +A G N A AR+ +D VG + + A +S G Sbjct: 153 SKESIERAMRTLGAPNRAEALAVDARQELDLKVGVAFTRFQTRFFQGRYSHLDASVISYG 212 Query: 195 RVQSVAVRLVVEREREIKAFVPEEFWEVDAST-TTPSGEALALQVTHQNDKPFRPVNKEQ 253 Q+ + V+R EI + PE+FW + +T G+ L + + R + + Sbjct: 213 PCQTPTLNFAVQRHLEIVSHTPEDFWSLHVEVRSTSLGKTLVTRWERE-----RVFDGDV 267 Query: 254 TQAAVSLLEKARYSVLEREDKPTTSKPGAPFI-TSTLQQAASTRLGFGVKKTMMMAQRLY 312 + S++ R++++E ++ K P + T L +AAS +G G + M +A+RLY Sbjct: 268 GEMFRSMVAGDRHALVESVEETEEFKRRPPGLNTVDLLKAASAGMGMGAHRAMQVAERLY 327 Query: 313 EAGYITYMRTDSTNLS-----QDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEA 367 G+I+Y RT+ST + + RG+ + L + H Sbjct: 328 IQGFISYPRTESTAYPPGFDLKGTLKAQRGHPDWGEWVEELLAGSMTKPRGGKDEGDHPP 387 Query: 368 IRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGR 427 I P V ES +A +LY + R F+A Y S T+ AG R + G+ Sbjct: 388 ITP--VRSATESAVG-GGEAWRLYDFVARHFIASVSPDCAYVSRRATLVAGGERFRVSGQ 444 Query: 428 ILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE 487 + GWT VMP + ED L + +G++L + + Q T PP SEA L+ +E Sbjct: 445 TVIAPGWTTVMP--HRAVEDDPLGEIERGESLPIATVELRQGATSPPPYLSEAELIGLME 502 Query: 488 KRGIGRPSTYASIISTIQDRGYVRVEN---RRFYAEKMGEIVTDRLEENFRELMNYDFTA 544 + GIG ++ + I+ I+ R YV +++ RR +G + EL + Sbjct: 503 RNGIGTDASIPTHINNIESRKYVTIQSQGGRRVVPTDLGVTLVQGYHRIDPELALPAVRS 562 Query: 545 QMENSLDQVANHEAEWKAVLDHF-------FSDFTQQLDK------AEKDPEEGGMRPNQ 591 +E LD +A +A+ ++++ H F +F Q+++ A DP +P Sbjct: 563 HVEKQLDMIATGKADHESIVRHTLAQFAAKFRNFVDQIERMDTLFEASFDPTCSSGKPFS 622 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 C C R M R ST P + C T + EVL + G Sbjct: 623 ------KCGRCLRYM--RLVST----------RPQRLYCPT------QEEVLELPAG--- 655 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFR-----IKGYDG 706 T L R C CG + Y + R +C P C + G R + G Sbjct: 656 -TVKLYNNRECQLCGFELLLYQ-NGDRTYPMC---PWCFNHPPFVGGSRPTKGLVSGAPH 710 Query: 707 P----------IVECEKCGSEMHLKMGRFGKYM 729 P + C +CG + LK GR G ++ Sbjct: 711 PRAHPIVDALVVCPCPECGEDDKLK-GREGGWL 742 >UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 Length = 679 Score = 146 bits (369), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 176/695 (25%), Positives = 295/695 (42%), Gaps = 105/695 (15%) Query: 5 LVIVESPAKAKTINKYLG------------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 L + E P++AK I K LG D +V + GHI + ++ AD + Sbjct: 3 LFLCEKPSQAKDIGKVLGVLGGRHDGYFQNGDTIVTWAFGHILTQAAPDAYGEQYADFGN 62 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 ++ + + P W+ +V P K +K L KAD + +ATD Sbjct: 63 ---------------ISALPILP-EVWQM--QVPPKVSKQFKVIKSLLAKADEVVIATDA 104 Query: 113 DREGEAIAWHLREVIG--GDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQAR 168 DREGE IA RE++ G + SR + + ++++A + PG+ + A AR Sbjct: 105 DREGEVIA---REILDYCGYRKKISRFWTSGLDTQSVKKALSSIMPGKDKENLYQAGLAR 161 Query: 169 RFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFW-- 220 D +VG +S + G LS GR+Q+ ++LVV+R++EI FVP ++ Sbjct: 162 GRADWLVGMNLSRAYTAAYSAGYGREHILSIGRIQTPTLKLVVQRDKEIDTFVPYNYYTL 221 Query: 221 EVDASTTTPSGEALALQVTHQ-NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSK 279 VD T S QV + N E +A V LEK+ V+ + ++ Sbjct: 222 SVDFETADKSVFTTLWQVPENWRNTDGYCTNLEAVKALVKQLEKSTGKVITSNKERKSTP 281 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT-YMRTDSTNLSQDAVNMVRGY 338 P P+ S LQ+ A +LG K + +AQ LYE IT Y RT L + ++ V+ Sbjct: 282 PPLPYSLSALQKEAGKKLGLSASKVLKIAQTLYEKYKITSYPRTPCRYLPKSQMSEVKDV 341 Query: 339 IS--DNFGKKYL-------PESPNQ-YASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ 388 + K L PE ++ + + ++ +H AI P+ + S+ ++ + Sbjct: 342 FAAIQTIDKSMLSVIEKADPERQSRVWNDNQVNKHSHHAIIPTKASNFDLSV--LDKNEL 399 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR 448 +Y++I +++A +YDST + V A KA + GW KV+ + D+ Sbjct: 400 TVYRMIRDRYIAQFYPDFEYDSTVVEVEACSHLFKASSQSPVISGW-KVLLGKDVFEGDQ 458 Query: 449 I-----LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE---------------- 487 I LP + D + + P T PP RF+EASL+ E++ Sbjct: 459 IDEGPALPHLKVNDEVDTLSFNPETKKTTPPPRFTEASLLDEMQTLKDFLKNVEDEQIRK 518 Query: 488 ----KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFT 543 G+G +T A+II + + GY+ + + YA + G + R+ + + T Sbjct: 519 ILKSTEGLGTEATRATIIDRLFEMGYMEKKRSKIYATEKGRNLIARIPTMIADPIT---T 575 Query: 544 AQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP----------NQMV 593 A+ E +L + + + + T+ + +A+KD G RP Q V Sbjct: 576 AKWELALAGIEAGKLTLAEFMAYQQKVITELVGQAKKD-AVGKARPPKQTDSAGTKKQAV 634 Query: 594 LTSID--CPTCG----RKMGIRTASTGVFLGCSGY 622 + D CPTC R+ G + + GCS + Sbjct: 635 ARNEDDVCPTCKEGRLRQRGFKENPDKRYWGCSRF 669 >UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=Q4QPE8_HAEI8 Length = 686 Score = 146 bits (368), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 156/603 (25%), Positives = 255/603 (42%), Gaps = 95/603 (15%) Query: 85 VLPGK---------EKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYS 135 ++PGK +K + + +L ++A + +ATD+DREGE IA L + + G + Sbjct: 73 IIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIATDIDREGETIARELLD-LAGFRGQIK 131 Query: 136 RVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA----- 188 R+ + + +IR+A K E + A AR D ++G S L + +A Sbjct: 132 RLWLSALDDTSIRKALGALKNNEETLPLYYAGLARSRADWLIGMNFSRL-YTLLAQQQGY 190 Query: 189 --RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT-----------------TP 229 + LS GRVQ+ + LVV R+REIK F+P++ + + + P Sbjct: 191 QGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFALQVMLSDGNQHFATQYVIPEQYCDP 250 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTL 289 G L+ QV ++ R QA V +E R ER++ P F S L Sbjct: 251 DGLCLSAQVIQAANQQIRQFG----QAKVESVETKR----ERQNAPLC------FALSDL 296 Query: 290 QQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTNLSQ----DAVNMVRGYI-SDN- 342 Q A+ G G ++ + +AQ LYE TY RTD L + +A +++ + SDN Sbjct: 297 QSEANRLYGLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPQIIQCLLQSDNR 356 Query: 343 ----FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 G L + + K+ + AH I P+ + + D E KLY LI R++ Sbjct: 357 LHPLAGMLNLNQKSRVWNDKKIT--AHHGIIPTMIKADISKMSDEEL---KLYDLIRRRY 411 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED--RILPAVNKG 456 +A + ++ D T + + G L ARG +L GW + D+D + LP + +G Sbjct: 412 LAQFLPVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQALPTLKQG 471 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYAS 499 + + T PP F+E +L+ + E G+G +T A Sbjct: 472 QICQISDSEIKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGLGTEATRAG 531 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 I + D+G+++ + + A + D L + ++ TA E +L+Q+ AE Sbjct: 532 TIQGLIDKGFLKKKGKSLLATDEAMTLIDNLPQMLKD---PGLTALWEQALNQI----AE 584 Query: 560 WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC 619 L+ F + D + GM + + CP CG M R G F GC Sbjct: 585 RTLSLEVFMQKQEVFVRHLMADCLKKGMSLGNIEIRK--CPKCGAPMIKRNGKNGAFFGC 642 Query: 620 SGY 622 S Y Sbjct: 643 SAY 645 >UniRef50_A2BLA3 DNA topoisomerase n=1 Tax=Hyperthermus butylicus DSM 5456 RepID=A2BLA3_HYPBU Length = 682 Score = 145 bits (367), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 165/653 (25%), Positives = 270/653 (41%), Gaps = 96/653 (14%) Query: 1 MGKALVIVESPAKAKTINK--------------------YLGSDYVVKSSVGHIRDLPTS 40 G LVI E P A+ I + ++G+ YV+ + GH+ L T Sbjct: 11 FGYTLVIAEKPKAARKIAEALSDKPIACKLGGIPYWIVTWMGTRYVIVPAAGHLFGLTT- 69 Query: 41 GSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDP-WH--NWEAHYEVLPGKEKVVSELK 97 D+ G V P W + AH + + +K Sbjct: 70 ---------------------DKHGFPVFEYYWAPLWAVDSSSAH------TRRFLEAIK 102 Query: 98 QLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL 157 +LA A A D D EG I +++ +G + R R F+ +T+ +R+AF++ L Sbjct: 103 KLARHAVRFVNACDYDIEGSVIGYNILRALGVEK-RALRAKFSALTRQDVRRAFSRLERL 161 Query: 158 NIDRVNAQQARRFMDRVVGYMVSPLLWKKI------ARGLSAGRVQSVAVRLVVEREREI 211 + D +NA AR +D + G +S L + + ++ LSAGRVQS + V R + Sbjct: 162 DWDMINAGLARHELDWLWGINISRALMESLRSVTGRSKVLSAGRVQSPTLVEAVSRTIKR 221 Query: 212 KAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLER 271 FVP ++ V A T G+A LQV + E + A L V E Sbjct: 222 NLFVPLPYFTVTA-TVELGGKARRLQVASFE------LRSEAQRVARQLRATGYLVVREY 274 Query: 272 EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNL--SQ 329 + P PF LQ AS LGF T +A+ LY G I+Y RT+S + + Sbjct: 275 SEYVERIPPPYPFNLGDLQVEASRILGFSPYYTQKLAEELYLEGLISYPRTNSQKIPPTI 334 Query: 330 DAVNMVRGYISDNFGKK---YLPESPNQYASKENSQE---AHEAIRPSDVNVMAESLKDM 383 D +V+ + ++ YL + N + AH AI P+ + Sbjct: 335 DISAIVQALVRQTRYRELVEYLLRATRGVLRVNNGPKEDPAHPAIHPTG----EPPHSGL 390 Query: 384 EADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA-GDFRLKARGRILRFDGWTKVMPALR 442 + +LY LI R+F+A PA L + A G G + GW ++ + Sbjct: 391 SKNHLRLYDLIVRRFLASMAPPAVLVRARLILSAEGLGSASITGVRIVSPGWMQIYYWAK 450 Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 +E +P + +G + + ++ +T+PP ++ SLVK +E +GIG +T A I+ Sbjct: 451 PSEE--YIPRLYRGQRIQVKSVSVQTSYTQPPELHTKTSLVKWMESKGIGTEATRARIVE 508 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 + +RGY+R E R A ++G V + L+ F ++ + + T + E L+ + + A Sbjct: 509 LLFERGYLRSEGGRVQATELGLTVANILQTYFPDITSVELTRRFEELLEAIRMGKVSKDA 568 Query: 563 VLDH-------FFSDFTQQLDKA---EKDPEEGGMRPNQMVLTSIDCPTCGRK 605 V+ S+F + A E G ++P + CP CGR+ Sbjct: 569 VISEARRFLAGILSEFKVKSMHAVGMELAYSLGLLKPPR------QCPICGRR 615 >UniRef50_D2VSX3 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2VSX3_NAEGR Length = 1015 Score = 145 bits (366), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 160/632 (25%), Positives = 255/632 (40%), Gaps = 91/632 (14%) Query: 91 KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYS-------RVVFNEIT 143 ++ L+Q A A + L D DREGE IA+ + EV + S R F+E T Sbjct: 118 EIQQNLEQEARYATKLLLWLDCDREGENIAFEVIEVCKKVNRSLSIENDSILRARFSEFT 177 Query: 144 KNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS---PLLWKKIARGLSA-----GR 195 AI +A N+ A R+ +D +G + L KK +G++A G Sbjct: 178 AAAINRAIRNLERPNVLDSMAVDTRQELDLRIGASFTRFQSLRLKKKFQGITADYISYGP 237 Query: 196 VQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQ 255 Q + VV+R+ IK F E FW ++ T GE Q + + F +Q Sbjct: 238 CQFPTLGFVVKRDLIIKNFESESFWTLNC--THDMGEEGKAQFLWKRGRLF-----DQLT 290 Query: 256 AAVS---LLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLY 312 V +E R V+ E K P T LQ+ AS +L G +TM +A+ LY Sbjct: 291 CLVIYELCVEAQRARVVNVEKKRRYKYRPDPLNTIELQKLASQKLKMGSHETMKVAESLY 350 Query: 313 EAGYITYMRTDSTNLSQ----DAVNMVR---------GYISDNFGKKYLPESPNQYASKE 359 G+I+Y RT++ N +Q D +V GY SD Y + P S + Sbjct: 351 NKGFISYPRTETNNYNQFQDDDLKRLVNEHTSNPTWGGYASDLLNGGY--QKP---PSGK 405 Query: 360 NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD 419 +AH I P + ++ Q LY+LI R F+AC A T + + + Sbjct: 406 QDDKAHPPIHP-----LKGDCNSNDSKEQALYELIARHFLACCSKDAVGAETKVIISIAN 460 Query: 420 FRLKARG---------RILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 G I ++D W+ D+ +P N G L Sbjct: 461 EEFTCSGLMVEQKNFLEIWKYDRWS-----------DKSIPVFNAGQEFIPTSLLMDHGE 509 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP SE+ L+ ++ GIG +T A I TIQ+RGYV + RF A +G + Sbjct: 510 TRPPPHLSESDLISAMDSNGIGTDATVAQHIKTIQERGYVIKKGNRFEATNLGMALLQGY 569 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ----------QLDKA-E 579 + EL + ++ME + ++ E +AV+ S + LDKA + Sbjct: 570 DLIGYELSTPNLRSKMEKDMLSISKGEQSKEAVIHQSLSMYKHVYIQICKSAYLLDKAVQ 629 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC----SGYALPPKERCKTTIN 635 + G ++++ +C M ++ FL C Y LP K ++ + Sbjct: 630 QHFPTLGEGQSRVLGRGFSLCSCKNPMDLKEQDGNNFLHCKNCSDSYPLPSKSEYESIED 689 Query: 636 LVP--ENEVLNVLEGEDAETNALRAKRRCPKC 665 + P ++LN++ ++ + + CP C Sbjct: 690 VCPICNFQILNIITQKNT------SYKLCPHC 715 >UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermophilum RepID=Q67NT6_SYMTH Length = 783 Score = 145 bits (365), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 160/620 (25%), Positives = 265/620 (42%), Gaps = 103/620 (16%) Query: 2 GKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADS 50 GK L+I E P+ A I + LG ++Y++ ++GH+ +L Sbjct: 3 GKPLIIAEKPSAAMAIAQALGGFQRRDGYLESAEYLLSWAIGHLVEL------------- 49 Query: 51 TSTKTAKKPKKDERGALVNRMGVDP-WHNWEAH----------YEVLPGKEKVVSELKQL 99 + DP W W VLP L +L Sbjct: 50 -----------------LPPEAYDPRWKRWTMETLPILPEGFGLHVLPKTRSQFRTLARL 92 Query: 100 AEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGEL 157 ++A + A D REGE I ++ G + R+ + +T AIR AF KP E Sbjct: 93 GKQAPLLVNACDAGREGELIFRYICAAAGLEKP-VMRLWVSALTPAAIRAAFAEMKPQE- 150 Query: 158 NIDRV-NAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVP 216 + DR+ + + R D +VG + K LSAGRVQ+ + +VV REREI++F P Sbjct: 151 HYDRLYRSARCRAEGDWLVGINATRAFTVKFGELLSAGRVQTPTLAMVVRREREIESFRP 210 Query: 217 EEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPT 276 E +WEV A+ TP G + + R + + +A V + + V +++P Sbjct: 211 EPYWEVFAAFRTPDGREYTGKWFGPDGD--RLSSADAAEAVVRRVRRQAGWVEASDERPV 268 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV---- 332 +P F ++LQ+ A+ R G T+ AQ LYEA +ITY RTDS LS+ V Sbjct: 269 AERPPQLFDLTSLQREANRRYGLTAAATLKAAQALYEAKHITYPRTDSRYLSRALVPQLP 328 Query: 333 NMVRGYISDNFGKKYLPESP-------NQYASKENSQEAHEAIRPSDVNVMAESLKDMEA 385 +VR + + + N+ + H AI P+ + + SL EA Sbjct: 329 ALVRALSARSDLAALAAGADLSRVGFGNRRVVDDAKVTDHHAILPT--SEVPRSLTGAEA 386 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF--RLKARGRILRFDGWTKVMPALRK 443 K+Y LI R+F+A A++ + G+ R ++RGR L GW +V P + Sbjct: 387 ---KIYDLIVRRFLAQFYPDARFLEQEVVTCVGELPDRFRSRGRRLVDPGWRQVEPEPAR 443 Query: 444 GDED---------RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE------- 487 ++LP + G+ + + ++ + T+PP R++EA+L+ +E Sbjct: 444 KRRAAEDEEEEGLQLLPPLRMGEPVAVGDVESREKATRPPRRYTEATLLSAMEYAGREIT 503 Query: 488 ---------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE-L 537 G+G P+T A+II +++ GY+ E R G + + E E L Sbjct: 504 DEALREAMKGHGLGTPATRAAIIERLKEMGYIITERRSLVPTAKGRRLVELAERAGVEVL 563 Query: 538 MNYDFTAQMENSLDQVANHE 557 ++ + T + E+ + + + E Sbjct: 564 LSPELTGEWEHRIAGIQSGE 583 >UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF5_DESAS Length = 721 Score = 145 bits (365), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 154/599 (25%), Positives = 262/599 (43%), Gaps = 77/599 (12%) Query: 3 KALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ A+ I + L G+ Y+V ++GH+ L +K Sbjct: 2 KSLVLAEKPSVAREIARILNCTIKGKGYLEGNKYIVTWALGHLVTLAEPEDYDEKYKTWR 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATD 111 + P + + ++ + G +H +VS+L + + + I +ATD Sbjct: 62 TEDLPMLPA-EMKTVVIKKTGPQ-FH--------------IVSKLMKRPDVRELI-IATD 104 Query: 112 LDREGEAIA-WHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQAR 168 REGE +A W +++ + R+ + +T AIR+ F + PG + ++ R Sbjct: 105 AGREGELVARWIMKQ--ARCQKPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAICR 162 Query: 169 RFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D ++G V+ L K LSAGRVQ+ + ++V RE+EIK FVP +FW V A+ Sbjct: 163 AEADWLIGLNVTRALTVKYNAQLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANLGK 222 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 E ++ K R + Q + V+ +++ V++ + + +P + + Sbjct: 223 FQAEW-----RDKSGKHNRFSDCLQAETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLTE 277 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVR--------GYI 339 LQ+ A+ + G+ +KT+ Q LYE +TY RTDS L+ D V + GY Sbjct: 278 LQRDANKKFGYTAQKTLAGLQMLYERHKLVTYPRTDSRYLTSDMVPTLMPRLKAVSGGYF 337 Query: 340 SDNFGKKYLPESPNQYASKENSQEA-HEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 ++ P +NS+ H AI P+ +L + A+ + +Y LI R+F Sbjct: 338 AELVKPLTAKPLPINKRLVDNSKVTDHHAIIPTTERA---NLAALTAEEKNIYDLIVRRF 394 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM-PALRKGDE------DRILP 451 +A Y TT+ V A G+++ GW V R+ D ++ LP Sbjct: 395 IAVFYPAYSYKQTTVIVLIAGEHFHASGKVVTNPGWKAVYNNESREKDTGYDDTPEQNLP 454 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRPS 495 + KGD + ++ + TKPPAR++EASL+ +E + G+G P+ Sbjct: 455 PLKKGDKVKVLSCKSVKGQTKPPARYTEASLLSAMEHPGKFIEDEILKESVKESGLGTPA 514 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 T A II I YV + G + + + EL D TA+ E L +A Sbjct: 515 TRAEIIEKIISSNYVERRGKELIPTAKGIQLVELVPP---ELKQADLTAKWEQQLHDIA 570 >UniRef50_Q702B0 DNA topoisomerase n=1 Tax=uncultured crenarchaeote RepID=Q702B0_9CREN Length = 715 Score = 145 bits (365), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 165/678 (24%), Positives = 291/678 (42%), Gaps = 69/678 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVV--KSSVGHIRDLPTSGSAAKKSADST--STKTAK 57 G LVI E P AK I++ LGS ++ K S+G + TS + S + Sbjct: 11 GYQLVICEKPLAAKRISQVLGSKNIIEKKYSLGIVVFEITSDKNQRFVVCSALGHMYSLI 70 Query: 58 KPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA---EKADHIYLATDLDR 114 +K+ + + P H+ A+ +++++ LK +A E A A D D Sbjct: 71 PLEKNRKKYPIYETVWSPKHSTVAN-----QRKRILETLKVIARISEGASGYIHACDYDL 125 Query: 115 EGEAIAWHLREVIGGDDARYSR-VVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 EGE I +++ E SR F+ +T + I Q+FN + +I A +AR +D Sbjct: 126 EGELIGYNILEYACKHKYEQSRRAKFSSLTDSEINQSFNNLQQTDIRIAEAGKARHLVDF 185 Query: 174 VVGYMVSPLLWKKIA--------RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 V G +S L ++ LS GRVQ + +V+RE +I+ VP+ W + + Sbjct: 186 VFGINLSRALVNCLSVANQDNRYYNLSIGRVQGPTLGFIVDREIKIRKHVPDPVWYITGN 245 Query: 226 --TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 S +A H+ + Q ++ + + ++ + P P Sbjct: 246 FQKDNSSFQANLSTAIHKFS---------EMQKILATCKNGKATIKTVICQTKKVNPPTP 296 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNL-SQDAVNMVRGYISDN 342 F S LQ+ A T +A+ LY A I+Y RT S L S + +S N Sbjct: 297 FNLSDLQKEAFRIFKLSPAVTHSIAESLYLAALISYPRTSSKKLPSSIGYEKILNLLSKN 356 Query: 343 FG------------KKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKL 390 + +KYL P Q ++ AH AI P+ + K + K+ Sbjct: 357 YATADKNKIQELLMQKYL--VPFQGIEED---PAHPAIYPTGL-----KHKKLSVQQSKI 406 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRIL 450 LI ++F+A A + + + + + A+G + GW + E R L Sbjct: 407 LDLIIKRFLATFGDGALTNFSEVIITVSGYDFIAKGNTILNYGWIPLYEPYFSIKETR-L 465 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 P + KGD+ E+T + FTKP AR+++AS+++++E GIG ST A ++ + R Y+ Sbjct: 466 PHLVKGDSAQTNEVTALEDFTKPVARYNQASILEKMESEGIGTKSTRAETVNLLIKRNYI 525 Query: 511 RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 +G + D +++ ++++ TA +E+S+ +V E + + H Sbjct: 526 LQHKIGLEPTVLGFTILDTMKKFIPDIVSTKLTAFLESSIKRVEQGELDMINLRKHLEKS 585 Query: 571 FTQQLDK------AEKDPEEGGMRPNQMVLTSIDCPTC--GRKMGIRTASTGV-FLGCSG 621 + L++ A + + G+ +++ ++ CP C G + I++ T FL CS Sbjct: 586 LLKPLNRIKINEMAIGNEIKNGLTTSRVEMSYGKCPKCHIGEMVLIKSNKTKKRFLACSK 645 Query: 622 YALPPKERCKTTINLVPE 639 + + CK TI +VP+ Sbjct: 646 FRVTG---CK-TITIVPQ 659 >UniRef50_A5FFH7 DNA topoisomerase n=1 Tax=Flavobacterium johnsoniae UW101 RepID=A5FFH7_FLAJ1 Length = 689 Score = 144 bits (364), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 169/651 (25%), Positives = 278/651 (42%), Gaps = 96/651 (14%) Query: 5 LVIVESPAKAKTINKYLGSD-----------YVVKSSVGHIRDLPTSGSAAKKSADSTST 53 +VI E P+ A+ I LG++ Y V ++GH+ L K + +S Sbjct: 3 VVIAEKPSAAREIAVLLGANEKKDGYLAGNGYFVTWALGHLVGLGLPEDYGIKGFEKSSL 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 P V + +D A Y G +K + +K + +D I +ATD Sbjct: 63 PILPDPFL----LTVRKQKID------AGYTADAGAQKQLKTIKYVVGLSDLIIVATDAG 112 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFM 171 REGE I ++ E + + R+ + +T+ AIR+ KP A QAR Sbjct: 113 REGELIFRYIYEYLEFRKP-FVRLWISNLTEKAIRKGLENLKPASELDGLYLAAQARSRA 171 Query: 172 DRVVGYMVSPLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D +VG S L +A+G S GRVQ+ + LV R E K+F E +W+ Sbjct: 172 DWLVGINASQAL--SLAQGDGVFSLGRVQTPTLALVCSRYLENKSFNIEPYWQ------- 222 Query: 229 PSGEALALQVTH-QNDKPFRPV------NKEQTQAAVSLLEK--ARYSVLEREDKPTTSK 279 LQ+TH +N F + NK Q A+ +E+ A V E K +T + Sbjct: 223 -------LQLTHSRNFMLFTSISEKRWDNKRQAMDALRAIERNAATAWVSSVEIKNSTEQ 275 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYI 339 P F + LQ+ AST L +T+ +AQ LYE +I+Y RT S ++S D + + I Sbjct: 276 PPLLFDLTGLQKQASTDLSLSAGETLSIAQSLYEKQFISYPRTGSRSISADVWDEIPSLI 335 Query: 340 SDNFGKKYLPESP--------NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLY 391 ++ E+ N+ E H + P++ A S K+ +Y Sbjct: 336 KALGTRENFREAISTLKLGRLNKRIVSEAGVTDHHGLLPTERIPSALSGKE-----TAIY 390 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP-ALRKGDEDRIL 450 LI + + P + T + + F G + GW V L G+ + L Sbjct: 391 NLIAGRLLEAVSEPCIKEITKVNLQVLHFDFILSGSRIIESGWRGVKARFLESGEPGQEL 450 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLV----------------KELEKRGIGRP 494 P + +GD L + E + T PPA ++EA L+ K L+ GIG P Sbjct: 451 PEIKRGDELKIKESAVLEKATSPPALYTEAGLLSVMENAGKKSQDLQERKILQAIGIGTP 510 Query: 495 STYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 +T A+II T+ DR Y++ + + + G +V + +++ + + + TAQ E L ++ Sbjct: 511 ATRAAIIETLFDRKYIQRQGKSLIPTEKGLMVYELVKD--KRIADVAMTAQWETELWKIE 568 Query: 555 NHEAE---WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTC 602 N EA+ ++ ++ + + T++L + RP+ MV + CP C Sbjct: 569 NKEADAATFQKQMESYATSITKELLETP--------RPHDMV-PDLCCPRC 610 >UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIV4_FIBSS Length = 843 Score = 144 bits (362), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 157/617 (25%), Positives = 271/617 (43%), Gaps = 78/617 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L+I E P+ A + K LG+ K + + D A K Sbjct: 32 GKTLIIAEKPSVAADLVKVLGAKSFKKETAYYESDTTIVSHAIGHLVGIADPKDI----- 86 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLATDLDREGEAI 119 DER + M P + LP + +S L +L ++ D I A D REGE I Sbjct: 87 DERYKAWD-MKTLPMLPEKFPLVALPTTKAHLSALGKLIKRKDVTTIINACDAGREGELI 145 Query: 120 AWHLREVIGGDDAR---YSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFMDRV 174 +++ + I + + + R+ +T AI+ AF + E ++ NA R D + Sbjct: 146 FYYIVDYILKGNFKGKTFKRLWMQSMTPAAIKDAFEHLRTEEDMVNLRNAALCRSEADWL 205 Query: 175 VGYMVSPLLWKKIARGLSA-------------GRVQSVAVRLVVEREREIKAFVPEEFWE 221 VG S RGL+A GRVQ+ + ++V+RE E F+P++FW Sbjct: 206 VGMNGS--------RGLTAYNSSMGGFQITPCGRVQTPTLAIIVKREEERNRFIPQKFWT 257 Query: 222 VDASTTTPS----GEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTT 277 ++AS G+ + + D+ + ++ + Q ++ K + +E P+ Sbjct: 258 IEASFDNAGAGYQGKWFTVDKENGKDRVKQIFDEARAQEILAKC-KGKTGSIEETTAPSQ 316 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVR 336 K G + +TLQ+ A+ R GF K T+ +AQ LYE TY RTDS L +D V V+ Sbjct: 317 QKCGQLYDLTTLQREANNRFGFSAKTTLSIAQSLYEHYKATTYPRTDSRCLPEDYVAPVK 376 Query: 337 G-----------YISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEA 385 + + K Y+ +P + + + S H AI P+ V+ + L + E Sbjct: 377 ATLGKIEGPLAKFAQEALDKNYVKRTPKVFDNSKISD--HFAIIPT--GVVPKGLSEAE- 431 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD 445 +K+Y +I ++F+A PA+Y +TT + G+IL G+ + ++ D Sbjct: 432 --EKIYTMICQRFIAVFFPPAQYLNTTRITTVENETFITEGKILVDPGFKAIYG--KESD 487 Query: 446 EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KR 489 E+ +P +N A TL + + FTKPPA ++E++L+ +E +R Sbjct: 488 EESNIPKLNGNTAKTLA-IESKEDFTKPPAHYTESTLLSMMESAGKLVEDDELRDAMKER 546 Query: 490 GIGRPSTYASII-STIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN 548 G+G P+T A+II + D+ VR K +++ N L + + T + E Sbjct: 547 GLGTPATRAAIIEKLVSDKYVVRDGKEMIPTAKAFDLIKVLSAMNCEALTSPELTGEWEY 606 Query: 549 SLDQVANHEAEWKAVLD 565 +D ++ + +A ++ Sbjct: 607 KMDLISKGKESREAFMN 623 >UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0L167_HALNC Length = 680 Score = 143 bits (361), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 139/549 (25%), Positives = 241/549 (43%), Gaps = 56/549 (10%) Query: 96 LKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--K 153 + L ++A + +ATD DREGE IA L +G + R+ + + ++++A K Sbjct: 86 IATLLKRATEVVIATDADREGEMIARELMAFVGFK-GKVQRLWLSALDAASVKKALAALK 144 Query: 154 PGELNIDRVNAQQARRFMDRVVGY-MVSPLLWKKIARG----LSAGRVQSVAVRLVVERE 208 P + R D +VG + ++G S GRVQ+ + LVV R+ Sbjct: 145 PSAETAGLYQSALGRSRADWLVGMNLTRAFTLAGCSQGGEGVRSVGRVQTPTLSLVVARD 204 Query: 209 REIKAFVPEEFWEVDASTTTPSGEALALQVTH-QNDKPFRPVNKEQTQAAVSLLEKARYS 267 R+I+ F P ++E+ + +V D R V++ A S + + Sbjct: 205 RQIEHFKPVPYFELFGFFEAGQSFSTKWKVPEGAGDDAGRCVDQSIVDAVASKITGKTGT 264 Query: 268 VLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTN 326 V + E K + P PF STLQ+ S + G G ++ + +AQ LYE TY R+D Sbjct: 265 VSQYETKRISENPPLPFSLSTLQKTCSAKFGLGAQEVLDIAQALYETHKATTYPRSDCNF 324 Query: 327 LS----QDAVNMVRGYISDNFGKK----YLPESPNQYASKENSQEAHEAIRPSDVNVMAE 378 L Q+A ++V + + L S A AH AI P+ + Sbjct: 325 LPEEQFQEASSIVTALAKSDTEVQGIVDLLDFSRKSPAWNTKKITAHHAIIPTQTPPNMD 384 Query: 379 SLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM 438 ++ D E +++Y+LI RQ++A + +YD T + + + G+I + GW + Sbjct: 385 AMSDNE---RRVYELIRRQYLAQFLPNYEYDRTQIGISIEGELFQTTGKIDQVTGWRVLF 441 Query: 439 PALRKGDED-----RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------- 486 D++ + LPA+ +G L L A TKPP+R++E +L+ + Sbjct: 442 GKADASDDEPDDEVQTLPALTQGQTLPLSHTEIAAKQTKPPSRYTEGTLIDAMQTIGKNI 501 Query: 487 ----------EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE 536 E GIG +T A II+ + +RG++ + ++ + +G + D L ++ + Sbjct: 502 TDPRLKAILKENSGIGTEATRAGIIANLIERGFITKKGKQVISSDVGRQLIDALPDSVK- 560 Query: 537 LMNYDFTAQMENSLDQVANHEAE---WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMV 593 + TA E SL+++A + E ++A + F + Q+ K D RP Sbjct: 561 --SPALTALWEQSLEEIAEGKRELAGFEADVVKFITAIIDQIKKQHAD-APAPTRP---- 613 Query: 594 LTSIDCPTC 602 + DCPTC Sbjct: 614 --TADCPTC 620 >UniRef50_Q33E26 DNA topoisomerase n=5 Tax=Enterococcus faecium RepID=Q33E26_ENTFC Length = 787 Score = 143 bits (361), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 141/581 (24%), Positives = 261/581 (44%), Gaps = 47/581 (8%) Query: 80 EAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGD--DARYSRV 137 E YEV GK + S +K E AD I +ATD DREGE IA+++ ++ + R+ Sbjct: 82 ELKYEVSKGKNQQFSIVKSCLENADEIIIATDPDREGENIAYNIFKLCKQSIFNKPIKRL 141 Query: 138 VFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFMDRVVGYMVSPLLW-----KKIARG 190 N + + I + F + E I AR+ D +VG + L K I+ Sbjct: 142 WINSLVQKEIIKGFKNLRNSEETISYFKEANARQIADYLVGMNYTELYSLKLQEKGISGV 201 Query: 191 LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVN 250 +S GRVQ+ LVVE + IK F PE++ ++ TT +A+ +N + + Sbjct: 202 VSLGRVQTPVNTLVVENDLAIKNFRPEKYKTIECHTTDKQPKAI-----FKNSLEYFKLE 256 Query: 251 KEQTQAAVSLLEKARYSVLER-EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQ 309 K + L+ A ++++ E ++P F +Q+ A+ + + KKT + Q Sbjct: 257 KFEEDTKKFGLDSASTGIIKKIEVSKKQTEPQKLFSLGGIQEYANKKWKYSAKKTDKIIQ 316 Query: 310 RLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP--------ESPNQYASKENS 361 LY+ GY++Y RTDS ++ + ++ + + K L E ++ + Sbjct: 317 SLYDRGYLSYPRTDSELITTNEFEYLKANL--DVYKSVLGISIDTPCLEPKKRFVDNDKV 374 Query: 362 QEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQM--TPAKYDSTTLTVGAGD 419 E + I D+ +A ++ D + +Y+++ R+ AC M P KY++T +T+ Sbjct: 375 LEHYALIPTMDIPDIA----NLTLDEKNIYEIVTRR--ACLMFAEPYKYENTKVTLDVNG 428 Query: 420 FRLKARGRILRFDGWTKVMPALRKGDE-DRILPAVNKGDALTLVELTPAQHFTKPPARFS 478 G + GW +V L + D+ + LP ++ + + +++ TK P R + Sbjct: 429 LEFTTSGNVPISLGWKQVDTNLDESDDKEETLPKFHEQETIN-IDIRFIDKLTKEPKRLT 487 Query: 479 EASLVKE---LEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFR 535 E L+ + + K G+G P+T ++I+ T+ +R Y+++EN Y G ++ D + Sbjct: 488 EGKLLGKTGIMAKLGLGTPATRSNIVDTLLNREYIKIENTNVYPTPKGYLLWDLTKNKDL 547 Query: 536 ELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK-----DPEEGGMRPN 590 + + TA E SL ++A +A L + ++ + + +K D E + N Sbjct: 548 LIGKPENTAIWEESLGKIAQGNYTQEAFLRNIYNYINKTVSDLKKVEFTSDYLEKTVNQN 607 Query: 591 QMVLTSIDCPTCGRKMGIRTASTG----VFLGCSGYALPPK 627 + + S + I ++G +F SG A+ K Sbjct: 608 KFDIGSYQVEEKKKVYSILNITSGEQFVIFKNISGKAINKK 648 >UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YF11_METS5 Length = 681 Score = 143 bits (361), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 155/570 (27%), Positives = 264/570 (46%), Gaps = 67/570 (11%) Query: 5 LVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 LVI E P+ A I + LG +Y+V + GH+ ++ G A K + Sbjct: 3 LVITEKPSVALDIARALGKPTRRQGYLEVGEYLVTWTYGHLLEI---GEIAPKRWNLKDL 59 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 P+K E Y+++ GKE +++L E AD + D Sbjct: 60 PIF--PEKFE-------------------YDLIKGKESQFKVVRKLLEGADAVINCGDAG 98 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRFM 171 REGE I L E G +T++ + + + P + AR+ Sbjct: 99 REGELIVRELLEFTGYRGKVLRLWTSEALTRDVVLRELRRLRPSSEFDSLYYSALARQNG 158 Query: 172 DRVVGYMVSPLLWKKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 D +VG ++ L+ K G S GRVQ+ + ++V+R+REI+AF PE ++ V A Sbjct: 159 DWIVGINLTRLVTLKAGGGEVWSVGRVQTPTLAMIVKRDREIEAFKPEIYYVVLAGF--- 215 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED-KPTTSKPGAPFITST 288 GE V +N + R + +E+ + V+ L+ R +E+ D + +P ++ Sbjct: 216 EGEMKG--VMLRNGEEAR-LAREEAEQVVNALKSVRSGRVEKVDVERREERPPLLHSLTS 272 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 LQ+ A+T G K+T+ +AQ LYE I+Y RTD+ L + ++V+ + G+ Sbjct: 273 LQREANTLYGLSAKRTLDVAQSLYEEWKLISYPRTDARYLGEGNRDLVKDVLR-KLGRGE 331 Query: 348 LPESPNQYASK---ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMT 404 L ++ + + H AI P D +++ A +K+Y L++R+FV M Sbjct: 332 LVPRVDRVGKRVFDSSKLTDHHAIIPLD-----RPPENLPAIHRKVYDLVYRKFVGAFMD 386 Query: 405 PAKYDSTTLTVGA-GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVE 463 Y+ + + G+ L R L+ GW ++ P ED L + V+ Sbjct: 387 DYVYELQRVFIRLDGELFLVEGKRNLQL-GWMELYP-----HEDNPLKIPSGEVRKEWVK 440 Query: 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMG 523 Q TKPPARF+EASL++E+E+ G+G P+T A II T+ +RGYV + Y+ G Sbjct: 441 AEERQ--TKPPARFTEASLLREMERLGLGTPATRAGIIETLLERGYVERRGKSLYSTDKG 498 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQV 553 + D+L ++ ++++ D TA+ E L+++ Sbjct: 499 RELVDKLGDS--KVVSPDMTAEWERQLEEI 526 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_Q9KRB2 DNA topoisomerase 1 n=401 Tax=cellular organisms... 1075 0.0 UniRef50_Q8K9P7 DNA topoisomerase 1 n=2 Tax=Gammaproteobacteria ... 894 0.0 UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_... 743 0.0 UniRef50_C1SMY2 DNA topoisomerase n=1 Tax=Denitrovibrio acetiphi... 737 0.0 UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia st... 724 0.0 UniRef50_A7NJW2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A7NJW... 721 0.0 UniRef50_D1U7W1 DNA topoisomerase n=1 Tax=Desulfovibrio aespoeen... 714 0.0 UniRef50_B0MRI8 DNA topoisomerase n=1 Tax=Eubacterium siraeum DS... 713 0.0 UniRef50_B5EJ79 DNA topoisomerase n=61 Tax=Proteobacteria RepID=... 713 0.0 UniRef50_C9LSJ2 DNA topoisomerase n=3 Tax=Veillonellaceae RepID=... 712 0.0 UniRef50_A3EPL6 DNA topoisomerase n=2 Tax=Leptospirillum sp. Gro... 712 0.0 UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5... 712 0.0 UniRef50_C6BUQ9 DNA topoisomerase n=14 Tax=Desulfovibrionales Re... 712 0.0 UniRef50_B9L0B0 DNA topoisomerase n=1 Tax=Thermomicrobium roseum... 711 0.0 UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8... 707 0.0 UniRef50_C1F6V0 DNA topoisomerase n=1 Tax=Acidobacterium capsula... 706 0.0 UniRef50_D1C7I9 DNA topoisomerase n=8 Tax=Bacteria RepID=D1C7I9_... 701 0.0 UniRef50_C6HWV0 DNA topoisomerase n=1 Tax=Leptospirillum ferrodi... 700 0.0 UniRef50_A8ZW15 DNA topoisomerase n=3 Tax=Desulfobacteraceae Rep... 700 0.0 UniRef50_D0LR99 DNA topoisomerase n=169 Tax=cellular organisms R... 699 0.0 UniRef50_D1BMP2 DNA topoisomerase n=6 Tax=Firmicutes RepID=D1BMP... 699 0.0 UniRef50_Q67PC7 DNA topoisomerase n=3 Tax=Bacteria RepID=Q67PC7_... 699 0.0 UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_... 696 0.0 UniRef50_Q9KA23 DNA topoisomerase 1 n=107 Tax=Bacteria RepID=TOP... 691 0.0 UniRef50_B1GYR4 DNA topoisomerase n=1 Tax=uncultured Termite gro... 691 0.0 UniRef50_Q2LT40 DNA topoisomerase n=2 Tax=Bacteria RepID=Q2LT40_... 687 0.0 UniRef50_C0QYG0 DNA topoisomerase n=2 Tax=Brachyspira RepID=C0QY... 682 0.0 UniRef50_A9FRC6 DNA topoisomerase I n=1 Tax=Sorangium cellulosum... 681 0.0 UniRef50_B9L7D9 DNA topoisomerase n=1 Tax=Nautilia profundicola ... 681 0.0 UniRef50_Q7NGH1 DNA topoisomerase n=1 Tax=Gloeobacter violaceus ... 680 0.0 UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM ... 679 0.0 UniRef50_C0W9S2 DNA topoisomerase n=1 Tax=Acidaminococcus sp. D2... 678 0.0 UniRef50_A0LDV2 DNA topoisomerase I n=7 Tax=Proteobacteria RepID... 677 0.0 UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=T... 676 0.0 UniRef50_B5YKX8 DNA topoisomerase n=1 Tax=Thermodesulfovibrio ye... 672 0.0 UniRef50_A6DDI1 DNA topoisomerase n=1 Tax=Caminibacter mediatlan... 671 0.0 UniRef50_Q2FZ32 DNA topoisomerase 1 n=260 Tax=Bacteria RepID=TOP... 670 0.0 UniRef50_D1B6D6 DNA topoisomerase I n=3 Tax=Synergistaceae RepID... 669 0.0 UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM ... 668 0.0 UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophi... 664 0.0 UniRef50_B3EPW7 DNA topoisomerase n=12 Tax=Chlorobiaceae RepID=B... 662 0.0 UniRef50_C1ABE5 DNA topoisomerase n=1 Tax=Gemmatimonas aurantiac... 661 0.0 UniRef50_Q01N68 DNA topoisomerase n=7 Tax=Bacteria RepID=Q01N68_... 654 0.0 UniRef50_B8E2F6 DNA topoisomerase n=1 Tax=Dictyoglomus turgidum ... 654 0.0 UniRef50_B2KBN6 DNA topoisomerase n=1 Tax=Elusimicrobium minutum... 652 0.0 UniRef50_D1B572 DNA topoisomerase n=7 Tax=Campylobacterales RepI... 649 0.0 UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus R... 648 0.0 UniRef50_D1Y390 DNA topoisomerase n=1 Tax=Pyramidobacter piscole... 645 0.0 UniRef50_A8RBU5 DNA topoisomerase n=9 Tax=Bacteria RepID=A8RBU5_... 644 0.0 UniRef50_C6WSV7 DNA topoisomerase n=4 Tax=Proteobacteria RepID=C... 641 0.0 UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria Re... 640 0.0 UniRef50_A8SJ74 DNA topoisomerase n=1 Tax=Parvimonas micra ATCC ... 639 0.0 UniRef50_B0VJB5 DNA topoisomerase n=1 Tax=Candidatus Cloacamonas... 638 0.0 UniRef50_Q256J1 DNA topoisomerase I-fused to SWI domain n=18 Tax... 636 0.0 UniRef50_C6P2V7 DNA topoisomerase n=2 Tax=Proteobacteria RepID=C... 636 0.0 UniRef50_O83409 DNA topoisomerase 1 n=4 Tax=Treponema RepID=TOP1... 635 e-180 UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria ... 633 e-180 UniRef50_Q1RIM1 DNA topoisomerase 1 n=35 Tax=Rickettsiales RepID... 629 e-178 UniRef50_B1M0P4 DNA topoisomerase n=14 Tax=Alphaproteobacteria R... 627 e-178 UniRef50_D0KVS8 DNA topoisomerase n=6 Tax=Gammaproteobacteria Re... 625 e-177 UniRef50_Q9ZMV7 DNA topoisomerase 1 n=47 Tax=Epsilonproteobacter... 622 e-176 UniRef50_B1VM20 DNA topoisomerase n=6 Tax=Streptomyces RepID=B1V... 617 e-175 UniRef50_C1D174 DNA topoisomerase n=34 Tax=cellular organisms Re... 617 e-175 UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q... 615 e-174 UniRef50_D0D7V2 DNA topoisomerase n=1 Tax=Citreicella sp. SE45 R... 615 e-174 UniRef50_Q47L55 DNA topoisomerase n=4 Tax=Actinomycetales RepID=... 615 e-174 UniRef50_Q28MI5 DNA topoisomerase n=13 Tax=Rhodobacterales RepID... 612 e-173 UniRef50_Q9X909 DNA topoisomerase 1 n=14 Tax=cellular organisms ... 612 e-173 UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms R... 612 e-173 UniRef50_P34185 DNA topoisomerase 1 n=39 Tax=Bacteria RepID=TOP1... 608 e-172 UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria... 607 e-172 UniRef50_D0LEI6 DNA topoisomerase n=36 Tax=Actinomycetales RepID... 604 e-171 UniRef50_A5CF60 DNA topoisomerase n=2 Tax=Orientia tsutsugamushi... 603 e-170 UniRef50_D0GKB0 DNA topoisomerase n=1 Tax=Leptotrichia goodfello... 601 e-170 UniRef50_C7NA27 DNA topoisomerase n=20 Tax=Fusobacteriaceae RepI... 600 e-170 UniRef50_B8DVL2 DNA topoisomerase n=14 Tax=Actinobacteridae RepI... 599 e-169 UniRef50_O69548 DNA topoisomerase 1 n=28 Tax=Actinomycetales Rep... 597 e-169 UniRef50_Q1UZD4 DNA topoisomerase n=4 Tax=Bacteria RepID=Q1UZD4_... 595 e-168 UniRef50_P73810 DNA topoisomerase 1 n=13 Tax=cellular organisms ... 593 e-168 UniRef50_Q2J4Z1 DNA topoisomerase n=10 Tax=Bacteria RepID=Q2J4Z1... 593 e-167 UniRef50_D1N8U4 DNA topoisomerase n=1 Tax=Victivallis vadensis A... 592 e-167 UniRef50_A4CJB9 DNA topoisomerase n=4 Tax=Bacteria RepID=A4CJB9_... 586 e-165 UniRef50_A6DJX4 DNA topoisomerase n=2 Tax=Bacteria RepID=A6DJX4_... 585 e-165 UniRef50_C7MGF4 DNA topoisomerase n=5 Tax=Actinobacteridae RepID... 584 e-165 UniRef50_B3DUA2 DNA topoisomerase n=13 Tax=Actinobacteridae RepI... 582 e-164 UniRef50_C4FH65 DNA topoisomerase n=1 Tax=Bifidobacterium angula... 582 e-164 UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2... 581 e-164 UniRef50_Q83FM2 DNA topoisomerase n=2 Tax=Tropheryma whipplei Re... 580 e-164 UniRef50_C0W593 DNA topoisomerase n=1 Tax=Actinomyces urogenital... 580 e-164 UniRef50_C1E9E3 DNA topoisomerase n=1 Tax=Micromonas sp. RCC299 ... 578 e-163 UniRef50_A8F3N1 DNA topoisomerase n=2 Tax=Thermotogaceae RepID=A... 577 e-163 UniRef50_C6V581 DNA topoisomerase n=2 Tax=Neorickettsia RepID=C6... 573 e-162 UniRef50_Q6XZ01 DNA topoisomerase n=2 Tax=Spiroplasma RepID=Q6XZ... 572 e-161 UniRef50_C6XXX5 DNA topoisomerase n=76 Tax=Bacteria RepID=C6XXX5... 569 e-160 UniRef50_A9BI47 DNA topoisomerase n=3 Tax=Thermotogaceae RepID=A... 566 e-159 UniRef50_Q31J81 DNA topoisomerase n=6 Tax=Bacteria RepID=Q31J81_... 563 e-158 UniRef50_A4RYV6 DNA topoisomerase (Fragment) n=5 Tax=cellular or... 558 e-157 UniRef50_A8EWX5 DNA topoisomerase I n=2 Tax=Campylobacterales Re... 555 e-156 UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=... 553 e-155 UniRef50_D2QCS0 DNA topoisomerase I n=1 Tax=Spirosoma linguale D... 553 e-155 UniRef50_B7I2H2 DNA topoisomerase n=4 Tax=Proteobacteria RepID=B... 553 e-155 UniRef50_C3JAB5 DNA topoisomerase n=3 Tax=Bacteria RepID=C3JAB5_... 550 e-155 UniRef50_B1M9R9 DNA topoisomerase I n=4 Tax=root RepID=B1M9R9_METRJ 550 e-154 UniRef50_C5Z4V5 DNA topoisomerase (Fragment) n=12 Tax=cellular o... 548 e-154 UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_... 545 e-153 UniRef50_Q3M6J7 DNA topoisomerase n=12 Tax=Cyanobacteria RepID=Q... 544 e-153 UniRef50_B5TTQ4 TraB n=3 Tax=environmental samples RepID=B5TTQ4_... 542 e-152 UniRef50_A1AXT2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A1AXT... 538 e-151 UniRef50_A8II62 DNA topoisomerase (Fragment) n=1 Tax=Chlamydomon... 536 e-151 UniRef50_P78032 DNA topoisomerase 1 n=2 Tax=Mycoplasma RepID=TOP... 536 e-150 UniRef50_O34204 DNA topoisomerase 1 n=8 Tax=Thermotogaceae RepID... 536 e-150 UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6Y... 533 e-150 UniRef50_B1VAJ5 DNA topoisomerase n=6 Tax=Acholeplasmataceae Rep... 533 e-149 UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms Rep... 531 e-149 UniRef50_C6XEP4 DNA topoisomerase I n=1 Tax=Methylovorus sp. SIP... 529 e-148 UniRef50_B7KK14 DNA topoisomerase n=4 Tax=Cyanobacteria RepID=B7... 526 e-147 UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF... 524 e-147 UniRef50_B7J7I8 DNA topoisomerase I, putative n=1 Tax=Acidithiob... 524 e-147 UniRef50_Q8EVZ3 DNA topoisomerase n=1 Tax=Mycoplasma penetrans R... 523 e-146 UniRef50_B1AJN1 DNA topoisomerase I n=15 Tax=Ureaplasma RepID=B1... 523 e-146 UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms Re... 523 e-146 UniRef50_A3BAP2 DNA topoisomerase n=6 Tax=Poaceae RepID=A3BAP2_O... 522 e-146 UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepI... 517 e-145 UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J35... 515 e-144 UniRef50_O66893 DNA topoisomerase 1 n=2 Tax=Aquificaceae RepID=T... 514 e-144 UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium bacul... 513 e-144 UniRef50_A4BJY7 Topoisomerase I n=1 Tax=Reinekea blandensis MED2... 513 e-143 UniRef50_Q18KP8 DNA topoisomerase n=6 Tax=Halobacteriaceae RepID... 512 e-143 UniRef50_Q1AY08 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 511 e-143 UniRef50_Q9JN65 DNA topoisomerase 1 n=2 Tax=Mycoplasma gallisept... 510 e-142 UniRef50_B1X1Z5 DNA topoisomerase n=3 Tax=Chroococcales RepID=B1... 508 e-142 UniRef50_B9LRP1 DNA topoisomerase n=4 Tax=Halobacteriaceae RepID... 507 e-142 UniRef50_Q9PHK2 DNA topoisomerase I, plasmid n=3 Tax=Gammaproteo... 507 e-141 UniRef50_D0JAY2 DNA topoisomerase n=2 Tax=Blattabacterium RepID=... 507 e-141 UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP... 505 e-141 UniRef50_C1MSJ2 DNA topoisomerase n=1 Tax=Micromonas pusilla CCM... 502 e-140 UniRef50_Q04TE1 DNA topoisomerase n=4 Tax=Leptospira RepID=Q04TE... 502 e-140 UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum aceto... 502 e-140 UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3... 502 e-140 UniRef50_Q185E5 DNA topoisomerase n=10 Tax=Clostridiales RepID=Q... 502 e-140 UniRef50_C8WG68 DNA topoisomerase type IA central domain protein... 500 e-140 UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria R... 500 e-140 UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae Rep... 498 e-139 UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boo... 497 e-139 UniRef50_C6I107 DNA topoisomerase n=1 Tax=Leptospirillum ferrodi... 496 e-138 UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae ... 496 e-138 UniRef50_UPI0001C41D8C DNA topoisomerase I TopA n=1 Tax=Methanob... 495 e-138 UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK... 495 e-138 UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris... 493 e-137 UniRef50_D2VSX3 Predicted protein n=1 Tax=Naegleria gruberi RepI... 491 e-137 UniRef50_Q4A5N2 DNA topoisomerase n=2 Tax=Mycoplasma RepID=Q4A5N... 491 e-137 UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus cald... 491 e-137 UniRef50_Q13472 DNA topoisomerase 3-alpha n=31 Tax=Eumetazoa Rep... 489 e-136 UniRef50_O95985 DNA topoisomerase 3-beta-1 n=72 Tax=Eukaryota Re... 487 e-136 UniRef50_A1U7T2 DNA topoisomerase I n=2 Tax=Marinobacter RepID=A... 487 e-136 UniRef50_B5JHP8 DNA topoisomerase n=2 Tax=Bacteria RepID=B5JHP8_... 487 e-136 UniRef50_B2V7T0 DNA topoisomerase I n=5 Tax=Aquificales RepID=B2... 486 e-135 UniRef50_UPI00016C444E DNA topoisomerase I n=1 Tax=Gemmata obscu... 486 e-135 UniRef50_D0LL88 DNA topoisomerase n=1 Tax=Haliangium ochraceum D... 485 e-135 UniRef50_O51768 DNA topoisomerase 1 n=22 Tax=Borrelia RepID=TOP1... 485 e-135 UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0... 484 e-135 UniRef50_C0A759 DNA topoisomerase n=4 Tax=Bacteria RepID=C0A759_... 484 e-135 UniRef50_Q21RE9 DNA topoisomerase III n=34 Tax=Bacteria RepID=Q2... 483 e-134 UniRef50_Q12Y06 DNA topoisomerase n=1 Tax=Methanococcoides burto... 483 e-134 UniRef50_UPI0001C314B9 DNA topoisomerase III n=1 Tax=Conexibacte... 481 e-134 UniRef50_Q3BT95 DNA topoisomerase n=14 Tax=Gammaproteobacteria R... 481 e-134 UniRef50_C4XEP1 DNA topoisomerase n=2 Tax=Mycoplasma RepID=C4XEP... 480 e-133 UniRef50_A3EW25 DNA topoisomerase n=3 Tax=Leptospirillum RepID=A... 479 e-133 UniRef50_Q5UQB5 DNA topoisomerase 1 type prokaryotic n=1 Tax=Aca... 479 e-133 UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 478 e-133 UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapo... 478 e-133 UniRef50_Q18AW1 DNA topoisomerase n=19 Tax=Bacteria RepID=Q18AW1... 477 e-133 UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=... 477 e-133 UniRef50_C9KMQ0 DNA topoisomerase n=5 Tax=Bacteria RepID=C9KMQ0_... 476 e-132 UniRef50_B2RH95 DNA topoisomerase III n=3 Tax=Bacteroidales RepI... 476 e-132 UniRef50_C0YH06 DNA topoisomerase n=4 Tax=Bacteroidetes RepID=C0... 476 e-132 UniRef50_D1BLQ5 DNA topoisomerase n=3 Tax=Veillonella RepID=D1BL... 475 e-132 UniRef50_B3PMD8 DNA topoisomerase I n=3 Tax=Mycoplasma RepID=B3P... 475 e-132 UniRef50_A8MIQ9 DNA topoisomerase n=2 Tax=Clostridiaceae RepID=A... 474 e-132 UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infe... 474 e-132 UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C... 474 e-132 UniRef50_Q9HM08 DNA topoisomerase 1 n=4 Tax=Thermoplasmatales Re... 473 e-131 UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermo... 472 e-131 UniRef50_Q9NG98 DNA topoisomerase 3-alpha n=10 Tax=Eukaryota Rep... 471 e-131 UniRef50_C3QFV7 DNA topoisomerase III n=28 Tax=Bacteroidales Rep... 470 e-131 UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribac... 470 e-130 UniRef50_C9LK04 DNA topoisomerase III n=3 Tax=Prevotella RepID=C... 469 e-130 UniRef50_Q46AN3 DNA topoisomerase n=3 Tax=Methanosarcina RepID=Q... 469 e-130 UniRef50_A5ZSZ0 DNA topoisomerase n=12 Tax=Bacteria RepID=A5ZSZ0... 469 e-130 UniRef50_Q5WAX6 DNA topoisomerase 3 n=137 Tax=Bacteria RepID=TOP... 469 e-130 UniRef50_A4JW73 DNA topoisomerase n=1 Tax=Burkholderia vietnamie... 469 e-130 UniRef50_A1TJM5 DNA topoisomerase n=55 Tax=Proteobacteria RepID=... 468 e-130 UniRef50_A1U3N5 DNA topoisomerase n=6 Tax=Gammaproteobacteria Re... 468 e-130 UniRef50_A3DB61 DNA topoisomerase n=1 Tax=Shewanella baltica OS1... 468 e-130 UniRef50_A5FHK0 DNA topoisomerase III n=25 Tax=cellular organism... 468 e-130 UniRef50_C7H9Z3 DNA topoisomerase n=32 Tax=Firmicutes RepID=C7H9... 467 e-130 UniRef50_C5B550 DNA topoisomerase n=1 Tax=Methylobacterium extor... 466 e-129 UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 466 e-129 UniRef50_B1ZYV6 DNA topoisomerase n=11 Tax=Bacteria RepID=B1ZYV6... 464 e-129 UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula ... 464 e-129 UniRef50_C7J0A2 DNA topoisomerase n=2 Tax=Magnoliophyta RepID=C7... 464 e-129 UniRef50_UPI00006CC0A9 DNA topoisomerase family protein n=1 Tax=... 464 e-129 UniRef50_O28469 DNA topoisomerase 1 n=8 Tax=Euryarchaeota RepID=... 464 e-129 UniRef50_C6N6E9 DNA topoisomerase n=2 Tax=Legionella drancourtii... 464 e-129 UniRef50_B7AD12 Putative uncharacterized protein n=4 Tax=Bactero... 463 e-128 UniRef50_Q9LVP1 DNA topoisomerase n=6 Tax=Embryophyta RepID=Q9LV... 463 e-128 UniRef50_C0FN62 DNA topoisomerase n=31 Tax=Bacteria RepID=C0FN62... 463 e-128 UniRef50_C4V616 DNA topoisomerase n=1 Tax=Selenomonas flueggei A... 462 e-128 UniRef50_A6GUS8 DNA topoisomerase n=1 Tax=Limnobacter sp. MED105... 462 e-128 UniRef50_A7FCC2 DNA topoisomerase n=1 Tax=Yersinia pseudotubercu... 462 e-128 UniRef50_C5PM09 Possible DNA topoisomerase n=1 Tax=Sphingobacter... 462 e-128 UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogen... 461 e-128 UniRef50_C0FPK2 Putative uncharacterized protein n=3 Tax=Clostri... 461 e-128 UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=... 460 e-128 UniRef50_Q02GM2 DNA topoisomerase n=10 Tax=Pseudomonas RepID=Q02... 460 e-127 UniRef50_B7GCB2 DNA topoisomerase (Fragment) n=1 Tax=Phaeodactyl... 460 e-127 UniRef50_A9V3W6 DNA topoisomerase n=1 Tax=Monosiga brevicollis R... 459 e-127 UniRef50_P14294 DNA topoisomerase 3 n=211 Tax=Gammaproteobacteri... 459 e-127 UniRef50_B1L3G6 DNA topoisomerase I n=1 Tax=Candidatus Korarchae... 459 e-127 UniRef50_A8U7S1 DNA topoisomerase n=2 Tax=Lactobacillales RepID=... 459 e-127 UniRef50_C7DGI7 DNA topoisomerase n=1 Tax=Candidatus Micrarchaeu... 458 e-127 UniRef50_Q5HLZ4 DNA topoisomerase 3 n=9 Tax=Staphylococcus RepID... 458 e-127 UniRef50_Q5ZHE3 DNA topoisimerase n=9 Tax=root RepID=Q5ZHE3_9BACT 457 e-127 UniRef50_Q7Q111 DNA topoisomerase n=3 Tax=Endopterygota RepID=Q7... 456 e-126 UniRef50_A4I3Q5 DNA topoisomerase III, putative n=8 Tax=Trypanos... 456 e-126 UniRef50_Q01NZ0 DNA topoisomerase n=2 Tax=Acidobacteria RepID=Q0... 456 e-126 UniRef50_Q099E1 Topoisomerase B n=1 Tax=Stigmatella aurantiaca D... 455 e-126 UniRef50_D1W4E5 DNA topoisomerase n=30 Tax=Bacteroidales RepID=D... 455 e-126 UniRef50_C6XWV5 DNA topoisomerase type IA central domain protein... 455 e-126 UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina E... 454 e-126 UniRef50_Q9KQF5 DNA topoisomerase 3 n=109 Tax=Gammaproteobacteri... 454 e-126 UniRef50_B0ERJ9 DNA topoisomerase n=2 Tax=Entamoeba RepID=B0ERJ9... 454 e-126 UniRef50_B6ADG7 DNA topoisomerase n=1 Tax=Cryptosporidium muris ... 454 e-126 UniRef50_C6BT42 DNA topoisomerase type IA central domain protein... 454 e-126 UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU... 453 e-125 UniRef50_B1L5U0 Reverse gyrase n=2 Tax=Archaea RepID=B1L5U0_KORCO 452 e-125 UniRef50_Q9U286 DNA topoisomerase n=3 Tax=Bilateria RepID=Q9U286... 452 e-125 UniRef50_C1DYX0 Predicted protein n=4 Tax=Viridiplantae RepID=C1... 451 e-125 UniRef50_B2RGV8 DNA topoisomerase I n=47 Tax=Bacteroidetes RepID... 450 e-125 UniRef50_C7HY28 DNA topoisomerase III n=1 Tax=Thiomonas intermed... 450 e-125 UniRef50_A3FPU5 DNA topoisomerase n=3 Tax=Cryptosporidium RepID=... 450 e-125 UniRef50_C1LZJ7 Prokaryotic DNA topoisomerase, putative n=1 Tax=... 450 e-124 UniRef50_UPI000186EA7F DNA topoisomerase 3-alpha, putative n=1 T... 450 e-124 UniRef50_B8G1K2 DNA topoisomerase n=2 Tax=Desulfitobacterium haf... 450 e-124 UniRef50_Q1QVL1 DNA topoisomerase n=1 Tax=Chromohalobacter salex... 449 e-124 UniRef50_A5FFH7 DNA topoisomerase n=1 Tax=Flavobacterium johnson... 449 e-124 UniRef50_B1HX02 DNA topoisomerase III n=93 Tax=Bacillaceae RepID... 449 e-124 UniRef50_A7I6L6 DNA topoisomerase n=5 Tax=Methanomicrobiales Rep... 449 e-124 UniRef50_O49571 DNA topoisomerase like-protein n=1 Tax=Arabidops... 448 e-124 UniRef50_UPI0000DB782E PREDICTED: similar to topoisomerase (DNA)... 448 e-124 Sequences not found previously or not previously below threshold: >UniRef50_Q9KRB2 DNA topoisomerase 1 n=401 Tax=cellular organisms RepID=TOP1_VIBCH Length = 876 Score = 1075 bits (2780), Expect = 0.0, Method: Composition-based stats. Identities = 614/869 (70%), Positives = 723/869 (83%), Gaps = 10/869 (1%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 MGK+LVIVESPAKAKTINKYLG D++VKSSVGH+RDLPT+G A + + + T K Sbjct: 1 MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60 Query: 61 KD--------ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 D ER AL+ +MGVDP+H W+A+Y++LPGKEKVV+EL++LA+ AD +YLATDL Sbjct: 61 TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 DREGEAIAWHLRE+IGGD+ RY RVVFNEITKNAI+QAF +PGELN+D VNAQQARRFMD Sbjct: 121 DREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180 Query: 173 RVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE 232 RVVG+MVSPLLWKK+ARGLSAGRVQSVAV+L+VEREREIKAFVPEEFW+++A T T + Sbjct: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQ 240 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 L V ++ F+PVN+ + AAV+ L KA+Y V +REDKPTTSKP APFITSTLQQA Sbjct: 241 DFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQA 300 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 ASTRLG+GVKKTMM+AQRLYEAGYITYMRTDSTNLS +AV +RGYI+ ++G+ YLP P Sbjct: 301 ASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQP 360 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 N Y SK+N+QEAHEAIRPSDV V A+ L+ MEADA KLY LIW QFVACQMTPA+YDSTT Sbjct: 361 NVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTT 420 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 ++V A ++ LKA+GRIL+FDGWT+V L K ED+ILP V GD+L LV L P QHFTK Sbjct: 421 VSVKAAEYTLKAKGRILKFDGWTRVQRPLGKN-EDQILPPVKVGDSLKLVSLDPKQHFTK 479 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PPAR++EA+LVKELEKRGIGRPSTYASIISTIQDRGYV+V+ RRF+AEKMGEIVTDRL+E Sbjct: 480 PPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDE 539 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 NF +LMNYDFTA+ME LDQ+A E W AVLD FF+DF++ L+ AE+D GGM+PN + Sbjct: 540 NFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHI 599 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 V+T+I CPTC R MGIRTASTGVFLGCSGY LPPKERCKTTINL E V+NVLE ED E Sbjct: 600 VMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLE-EDVE 658 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 T ALRAK+RCP C TAMD+YLID KRKLHVCGNNP C+G+ +EEGEF++KGY+GP VEC+ Sbjct: 659 TAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECD 718 Query: 713 KCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL 772 KCGS+M LK GRFGKYM CTN+ CKNTRKIL+NGEVAPPKE+PV PELPCE SDAYFVL Sbjct: 719 KCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVL 778 Query: 773 RDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFS 832 RDGA+G+F AA+ FPKSRETRAPLVEEL RF +RLPEK +YL AP DP+G +VRFS Sbjct: 779 RDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFS 838 Query: 833 RKTKQQYVSSEKDGKATGWSAFYVDGKWV 861 RK K+ YV +E +GK +GW A Y +GKW+ Sbjct: 839 RKEKEHYVRTETEGKPSGWMAVYQEGKWL 867 >UniRef50_Q8K9P7 DNA topoisomerase 1 n=2 Tax=Gammaproteobacteria RepID=TOP1_BUCAP Length = 853 Score = 894 bits (2311), Expect = 0.0, Method: Composition-based stats. Identities = 449/862 (52%), Positives = 615/862 (71%), Gaps = 16/862 (1%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+LVIVESP KAKTI+KYLG Y+VKSSVGH+RDL + + K Sbjct: 1 MCKSLVIVESPVKAKTISKYLGKQYIVKSSVGHVRDL------INNKSKNKKNIKKSNIK 54 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +E+ AL+ +MG++P+ NW+A Y +LPGKEK++SELK +A K +IYLATDLDREGEAIA Sbjct: 55 HNEKTALIQQMGINPYKNWKAEYHILPGKEKIISELKNIANKVHYIYLATDLDREGEAIA 114 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+EVIGG+ ++ RVVFNEITK +I +AF G++N++RV +QQARRFMDR+VGYM+S Sbjct: 115 WHLKEVIGGNSLKFRRVVFNEITKKSIEKAFQNIGKINMNRVYSQQARRFMDRIVGYMIS 174 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWKKI+RGLSAGRVQS AVRL+ +RE EIK F+ E W++ S + + + + +TH Sbjct: 175 PLLWKKISRGLSAGRVQSAAVRLITDREYEIKNFIEREHWKISLSLLSKENKKVTMDITH 234 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 +K F NK++ + + ++ + + +R+DK KP AP ITSTLQQA++ LGF Sbjct: 235 YRNKTFLLNNKKEVNSTIEKIKNLSFIITDRKDKIFKKKPPAPLITSTLQQASNIDLGFS 294 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 VKKTM +AQ+LYE GYITY+RTDS LS A+ VR YI + +G +LP+ N Y++++ Sbjct: 295 VKKTMFLAQKLYEQGYITYIRTDSYFLSNYAIEKVRSYIENFYGSDFLPKKSNIYSNQKY 354 Query: 361 SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF 420 SQEAHEAIRPSDV V+ ++ + + DA+KLY+LIW F+A QM +Y S TV A F Sbjct: 355 SQEAHEAIRPSDVQVV--NIDNCDPDAKKLYKLIWNYFIASQMKSERYKSIKTTVMADVF 412 Query: 421 RLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEA 480 +L++ +I+ F GWTK++ + + + P ++ G L L ++ P Q FTKPP RFSE+ Sbjct: 413 KLQSNTKIVLFSGWTKILK--KSNNVNFKFPVLDIGTTLILDKILPHQIFTKPPPRFSES 470 Query: 481 SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY 540 SLV+ELEK+GIGRPSTYA+II+ I+++GY++++ +FYA K+GEI+ RL++NF +L++Y Sbjct: 471 SLVRELEKKGIGRPSTYATIITKIKEKGYLKIKKNKFYAAKIGEILITRLKKNFSDLVDY 530 Query: 541 DFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP 600 DFTA+ME +LDQV++ WK +L+ FF +F+QQL++A+K PEEGGM N V T IDC Sbjct: 531 DFTARMEKNLDQVSDKLINWKHLLNSFFDNFSQQLEQAKKPPEEGGMELNTTVPTEIDCS 590 Query: 601 TCGRKMGIRTASTGVFLGCSGYALPPKER-CKTTINLVPENEVLNVLEGEDAETNALRAK 659 C +KMGI+TA TGVFL C GY P E+ CK TINL+ LN L E K Sbjct: 591 LCNKKMGIKTAVTGVFLSCLGYNSEPNEKRCKNTINLIS----LNDLSTTKKEEKNFHLK 646 Query: 660 RRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF-RIKGYDGPIVECEKCGSEM 718 RC KC MD YLI+ K+ +C NNP+C+GY +++G F + ++CEKC ++M Sbjct: 647 NRCKKCNLVMDVYLINENLKIFICINNPSCNGYNLKKGIFKKSLNCSLKKIKCEKCKNDM 706 Query: 719 HLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG 778 K GRFG + C N+ CKNTRKIL NGE++ PK +P+P P++ CEKS+ +FVLR+G +G Sbjct: 707 LFKTGRFGNFFMCINDTCKNTRKILPNGEISEPKFEPIPFPDILCEKSNTWFVLREGISG 766 Query: 779 VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQ 838 +F AANTFPKSRETR+P VEEL RF LP+KL YLA APQ+D +GNKT+V F++ KQQ Sbjct: 767 IFFAANTFPKSRETRSPFVEELARFEYLLPKKLHYLASAPQRDNKGNKTIVCFNKLNKQQ 826 Query: 839 YVSSEKDGKATGWSAFYVDGKW 860 Y++S+K+GK TGW+AF++D KW Sbjct: 827 YIASKKEGKFTGWAAFFIDRKW 848 >UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_ACIBL Length = 853 Score = 743 bits (1917), Expect = 0.0, Method: Composition-based stats. Identities = 319/829 (38%), Positives = 453/829 (54%), Gaps = 88/829 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI KYLG Y V++S+GHI+DLP G Sbjct: 1 MAKGLVIVESPAKAKTIQKYLGKGYEVEASLGHIKDLPKKG------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD +N++ Y V+PGKEKVV++LK+LA+ AD IYLA D DREGEAIA Sbjct: 42 ----------LGVDIENNFDTEYVVIPGKEKVVAKLKKLAKDADAIYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDA---------RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFM 171 HL E +G D + RV FNEITK A+++AF KP E++ + V+AQQ RR + Sbjct: 92 AHLAEELGDGDGKKKKKTDSKPFYRVTFNEITKKAVQEAFAKPREIDRNLVDAQQTRRIL 151 Query: 172 DRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 DR+VG+ VSPLLW K+ RGLSAGRVQ+VA+RL+VEREREIKAFV +E+W +DA Sbjct: 152 DRLVGFQVSPLLWDKVRRGLSAGRVQTVALRLIVEREREIKAFVSKEYWTIDAHLHGQKP 211 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + T + + N+E+++ V L+ A +SV +++ APF TS QQ Sbjct: 212 PDFDARFTGIDGEKLEVGNEEESKKIVDQLDNAEWSVRSVDNRERRRNAAAPFTTSKFQQ 271 Query: 292 AASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 AS +LG VK+ MM+AQ LYE G ITYMRTDST +S +A+ VR I + Sbjct: 272 DASRKLGMSVKRAMMIAQHLYEGVELGEEGTVGLITYMRTDSTRVSNEALTEVRELIGTS 331 Query: 343 FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 +G ++LPESPN Y K+++Q AHEAIRPS V + LK ++ D K+Y+LIW++FVA Sbjct: 332 YGPQFLPESPNVYKQKKDAQGAHEAIRPSSVAHTPDDLKAYLKDDEMKVYKLIWQRFVAS 391 Query: 402 QMTPAKYDSTTLTVGAG---DFRLKARGRILRFDGWTKVMPALRKGDEDR------ILPA 452 QM PA +D TT+ + A + + G +L+F+G+ KV ++G ++ LP Sbjct: 392 QMAPAVFDQTTVDIDAKADRTYNFRVTGSVLKFEGFLKVYEESKEGKDEEDDALKHKLPP 451 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 + +G LTL + P QHFT+PP R++EASLVKELE++GIGRPSTYA+I+STIQDRGYV+ Sbjct: 452 LVEGQTLTLKAIKPEQHFTEPPPRYNEASLVKELEEQGIGRPSTYAAILSTIQDRGYVQK 511 Query: 513 ---ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 +F+ ++G +VTD L NF+++ + FT++ME LD+V + + +W L F+ Sbjct: 512 TPGRGGKFFPTEIGMVVTDLLVANFKDIFDTKFTSRMEEELDEVEDGQKKWTDTLKEFYD 571 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 F LD A+K E T C CG + I+ G F CS Y Sbjct: 572 KFETNLDYAQKHMENIK---RMEKPTDEKCERCGSPLVIKWGKHGSFYACSSYDKKDPNS 628 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 C T + +++ + + A+ + C CG M + C P C Sbjct: 629 CTFT-----KENPIDLPDLDTADVQETEQEEYCENCGRGMV-LKRGRFGQFMACTGYPEC 682 Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEV 748 + +I +C +C + L+ GRFG++++C+ ECK ++ Sbjct: 683 KTTRRLDQAKKI-PDVPLDEKCPECTRPLVLRHGRFGEFVSCSGYPECKWIKQ------- 734 Query: 749 APPKEDPVPLPELPCEKS-DAYFVLRDGAAG-VFLAANTFPKSRETRAP 795 + C + + V + G F +PK T A Sbjct: 735 --------NFVGVKCPQCKEGEIVEKKARRGNFFYGCARYPKCDFTSAN 775 >UniRef50_C1SMY2 DNA topoisomerase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SMY2_9BACT Length = 782 Score = 737 bits (1902), Expect = 0.0, Method: Composition-based stats. Identities = 313/820 (38%), Positives = 450/820 (54%), Gaps = 67/820 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKA+TI KYLG ++ V +SVGH++DLP S Sbjct: 1 MPKNLVIVESPAKARTIEKYLGRNFKVLASVGHVKDLPASS------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD +++E Y ++ GK+K++ ELK++A A++IYLA D DREGEAIA Sbjct: 42 ----------LGVDLDNDFEPKYSIIRGKKKIIDELKKVANSAENIYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDA-RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ E +G + + RV+FNEITK I G +N +R NAQQARR +DR+VGY+V Sbjct: 92 WHIAEELGKKNKGKIYRVLFNEITKKGIEDGIKNTGPINENRTNAQQARRILDRLVGYLV 151 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SPLLWK + GLSAGRVQSVA+RL+VERE EI+ F PEE+W +D + L ++ Sbjct: 152 SPLLWKSLKYGLSAGRVQSVALRLLVEREEEIEKFKPEEYWLIDVTFKGGQKALLKARLE 211 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 +N K +R N E+ +A ++ L+ Y+V E K + PFITS LQQ A+ +L F Sbjct: 212 KKNGKKYRVPNGEEAEAVLAALKAGSYNVNEVIRKEVFERAPLPFITSKLQQEAARKLSF 271 Query: 300 GVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 K+TMM+AQRLYE G ITYMRTDST +S DA N RGYI +GK++L + Sbjct: 272 SAKRTMMLAQRLYEGIELGSEGPVGLITYMRTDSTRVSPDATNEARGYIEKQYGKEFLSK 331 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 + K+N Q+AHEAIRP+ V + ES+K ++ D KLY+LIW +FV+ M A YD Sbjct: 332 GVKGGSKKKNVQDAHEAIRPTSVAITPESVKKILDTDQYKLYKLIWDRFVSSNMADAVYD 391 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGDALTLVELTP 466 T+ + G + LK++G++++F G+ + K + ++ V +G+ L + Sbjct: 392 QNTIHIANGPYLLKSQGKVMKFPGFQTLYIEGVDESKEKDQEVIFDVKEGETLNPEKHDS 451 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 Q FT+PPAR+SEA+LVK LE GIGRPSTYASIIST+ DR Y +E +RF ++G +V Sbjct: 452 KQMFTQPPARYSEATLVKTLEAEGIGRPSTYASIISTLIDREYANMEEKRFKPTELGRVV 511 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG 586 L NF + FTA ME LD V E WK VL F++ F +L+KAEK Sbjct: 512 CSLLIANFDRIFEPKFTAGMEEDLDSVEAGELTWKGVLRDFYAKFKPELEKAEKQF---- 567 Query: 587 MRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVP-ENEVLNV 645 + + + CP C + + I+ G F+ C+ Y CK T N E+ + Sbjct: 568 ---SANLKIEMKCPVCEKDLTIKYGRNGNFVACTSYP-----ECKFTSNYERLEDGSFKL 619 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE----IEEGEFRI 701 + E+ + + + C KCG + ++ C P C + + +GE +I Sbjct: 620 VPKEEDKPSGIE----CEKCGKELVFKKTRFG-EVLACPGYPECKNIKNYVTLPDGEIKI 674 Query: 702 KGYDGPI-VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLP 759 I C KC + + +K GR G ++ C N +C T + N + + Sbjct: 675 LAAGEEIGTPCPKCEAGLTIKGGRNGMFIGCKNYPDCDFTANMEVNEQGDIIPKYDKVDE 734 Query: 760 ELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEE 799 + CEK VL+ G F A +P+ + ++ +V E Sbjct: 735 NVKCEKCGKPMVLKKSRRGKFFACTGYPECKNAKSTIVLE 774 >UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PYZ6_9BACT Length = 773 Score = 724 bits (1870), Expect = 0.0, Method: Composition-based stats. Identities = 324/822 (39%), Positives = 458/822 (55%), Gaps = 91/822 (11%) Query: 1 MGKA---LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAK 57 M K+ LVIVESPAKAKTI+K+L + + VKSS+GH+RDLP Sbjct: 1 MAKSKTNLVIVESPAKAKTISKFLDASFFVKSSMGHVRDLP------------------- 41 Query: 58 KPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGE 117 ++ VD +++ Y+V+P +EK++ EL ++KA +YLA+DLDREGE Sbjct: 42 ----------AKKLSVDIENDFTPEYKVIPSREKLIKELISDSKKASTVYLASDLDREGE 91 Query: 118 AIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGY 177 AIAWHL +V+ + RV FNEITK+AI++AF + G +N+++VNAQQARR +DR+VGY Sbjct: 92 AIAWHLYKVLDIPPEKIRRVTFNEITKDAIQEAFKQYGPINMEKVNAQQARRILDRIVGY 151 Query: 178 MVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG------ 231 +SPLLWKKIA+ LSAGRVQSVAVRL+VERE+EI F P E+W++ A T SG Sbjct: 152 KISPLLWKKIAKRLSAGRVQSVAVRLIVEREKEINEFKPHEYWKITAELKTISGDKKSDD 211 Query: 232 -EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 + + DK N++Q + L+ A + + + + + PF TS LQ Sbjct: 212 IKPFKALLQKLEDKNIEIKNEQQAKEITEKLQNASFIITNIKKQTKRNNAPPPFTTSLLQ 271 Query: 291 QAASTRLGFGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISD 341 Q ASTRL F KKTM++AQ+LYE AG ITYMRTDS ++S A+ R +I Sbjct: 272 QQASTRLQFSAKKTMLIAQQLYEGIDVGADGPAGLITYMRTDSFHVSDHALTSCRNFIES 331 Query: 342 NFGKKYLPESPNQYA-SKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFV 399 N+GK YLPE PN YA +K+ +Q AHEA+RP+ + ES+K + D KLY+LIW++FV Sbjct: 332 NYGKDYLPEKPNIYASNKKGTQGAHEAVRPTYLEYTPESIKQFLTKDQHKLYELIWKRFV 391 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 A QM PA Y T + + + + K RGR L FDG T + E++ILP + K L Sbjct: 392 ASQMKPALYAITDVEITSNRYIFKTRGRELLFDGHTLI-SGHEVDREEQILPPLEKDHVL 450 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 L++L P QHFT+PP R+SEASLVK LEK GIGRPSTYA+IISTIQDRGYV+ E R FYA Sbjct: 451 ELIQLLPTQHFTQPPPRYSEASLVKTLEKMGIGRPSTYATIISTIQDRGYVKQEKRAFYA 510 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 ++G +VT++L E+F+++M+ +FT+ ME+ LD++ + +W VL F+ F L+KA Sbjct: 511 TELGILVTEKLIEHFQKIMDVNFTSHMEDELDKIEEKKIDWLTVLKEFYEPFKIDLEKAI 570 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPE 639 + + P + + C C + M IR G F GCS + CK T+ L + Sbjct: 571 GEMKSVKGTPEE---SDRICNLCSKPMVIRWGRHGKFFGCSAFP-----ECKNTMPLDEK 622 Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF 699 E + + C KCG+ M K C P C + GE Sbjct: 623 GEAAP----------PETSDQACEKCGSPMII-KTSRHGKFMACSAYPNCKNTKSLTGET 671 Query: 700 RIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPL 758 + +CEKCGS M ++ + G++M C+ +C+N + + Sbjct: 672 --TKVEPTNEKCEKCGSPMVIRFSKKGRFMGCSGYPKCRNIKSLP--------------- 714 Query: 759 PELPCE--KSDAYFVLRDGAA-GVFLAANTFPKSRETRAPLV 797 + C + + R G+F + +P L Sbjct: 715 TGIKCPRDECGGDLIQRYSKKGGIFFGCSKYPDCDYISKELP 756 >UniRef50_A7NJW2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A7NJW2_ROSCS Length = 836 Score = 721 bits (1861), Expect = 0.0, Method: Composition-based stats. Identities = 310/803 (38%), Positives = 435/803 (54%), Gaps = 83/803 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 MG+ LVIVESPAKA+TI KYLGS Y V++S+GH+RDLP S Sbjct: 1 MGEKLVIVESPAKARTIQKYLGSGYRVEASMGHVRDLPKS-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD N+ YE+ PGKEK+++ L++ +AD +YLATD DREGEAIA Sbjct: 41 ---------NLGVDLEANFAPVYEISPGKEKIIAALRKSIRQADAVYLATDPDREGEAIA 91 Query: 121 WHLREVIG-GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ E D RVVF EIT A+R A P +++ V+AQQARR +DR+VGY + Sbjct: 92 WHITEAAKIPRDKPVYRVVFTEITPGAVRSAMASPRDIDRRLVDAQQARRVLDRLVGYKL 151 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-------- 231 SPLLW+K+ RGLSAGRVQSVAVRL+VEREREI+AFVP+E+W ++A + Sbjct: 152 SPLLWEKVRRGLSAGRVQSVAVRLIVEREREIEAFVPQEYWTIEADLLKQNASDSQRDAF 211 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 A+ ++ + + + F +Q QA ++ LE A Y V + + P PF TSTLQQ Sbjct: 212 RAMLIERSGKKLEKFDIGASDQAQAIIADLEGAAYIVRKVTRRDKRRSPAPPFTTSTLQQ 271 Query: 292 AASTRLGFGVKKTMMMAQRLYEA----------GYITYMRTDSTNLSQDAVNMVRGYISD 341 A +LGF K+TM +AQ+LYE G ITYMRTDS N+S++A R I + Sbjct: 272 EAGRKLGFSAKRTMAVAQQLYEGVDIGGDEGLVGLITYMRTDSVNVSREAQEEARRVIRE 331 Query: 342 NFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFV 399 FG+ YLP P Y +K + +QEAHEAIRP+ E ++ + +D +LY LIW++FV Sbjct: 332 RFGEAYLPAKPPVYKTKAKGAQEAHEAIRPTLSRRTPEQVQPYLTSDQYRLYDLIWKRFV 391 Query: 400 ACQMTPAKYDSTTLTVGAG-----------DFRLKARGRILRFDGWTKVMP-----ALRK 443 A QM A +DST + +GAG + +A G +L+F G+ V Sbjct: 392 ASQMEAAVFDSTVVDIGAGRDIGGRGAGSDPYTFRATGSVLKFPGFLAVYNVSLDEGEED 451 Query: 444 GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 503 D +R LP + +G+AL L++L P QHFT+PP RF+EASLVKELE+ GIGRPSTYA IST Sbjct: 452 EDSERRLPLLEEGEALNLLQLLPVQHFTEPPPRFTEASLVKELERLGIGRPSTYAPTIST 511 Query: 504 IQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 I +R YV + +++ +G +VTD L E+F +++Y FT++ME LD +A E EW V Sbjct: 512 IIEREYVELADKKLVPTTLGRVVTDLLVEHFPSIVDYGFTSEMEQQLDDIAEGEKEWAPV 571 Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK-MGIRTASTGVFLGCSGY 622 L F+ F Q+L +A++ + +LT + CP C + + ++ G FL C+ Y Sbjct: 572 LRAFYRPFEQKLAEAQRSMRNVK---REEILTDLTCPRCNQGQLAVKFGRNGEFLACNRY 628 Query: 623 ALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHV 682 C T + +++ VL DA + + C CG M Sbjct: 629 P-----ECDFTSDFHRDSDGRIVL---DAPASPETSDVLCDVCGRPMILKKSRFG-PFLG 679 Query: 683 CGNNPTCDGYEIEEGEFRIKGYDGPI-VECEKCG-SEMHLKMGRFG-KYMACTN-EECKN 738 C P C + + + V C KCG E+ + G+FG + C +C Sbjct: 680 CSGYPECKNTRRLDKQGKPAPLPKATGVTCPKCGQGELLERRGKFGRPFFGCNRYPKCDY 739 Query: 739 TRKILRNGEVAPPKEDPVPLPEL 761 L P + P+ Sbjct: 740 LVNSLDEVAHYTPDANEASKPQA 762 Score = 91.7 bits (226), Expect = 1e-16, Method: Composition-based stats. Identities = 21/88 (23%), Positives = 39/88 (44%), Gaps = 4/88 (4%) Query: 710 ECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRN--GEVAPPKEDPVPLPELPCEK 765 C +C ++ +K GR G+++AC EC T R+ G + ++ C+ Sbjct: 603 TCPRCNQGQLAVKFGRNGEFLACNRYPECDFTSDFHRDSDGRIVLDAPASPETSDVLCDV 662 Query: 766 SDAYFVLRDGAAGVFLAANTFPKSRETR 793 +L+ G FL + +P+ + TR Sbjct: 663 CGRPMILKKSRFGPFLGCSGYPECKNTR 690 >UniRef50_D1U7W1 DNA topoisomerase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7W1_9DELT Length = 821 Score = 714 bits (1843), Expect = 0.0, Method: Composition-based stats. Identities = 308/817 (37%), Positives = 433/817 (52%), Gaps = 84/817 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAK KTI+K+LG DY+V +SVGH+RDLPT Sbjct: 1 MPKDLIIVESPAKVKTISKFLGKDYMVDASVGHVRDLPTRD------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD + + YE++ GKE+VV LK A+KA +YLA D DREGEAIA Sbjct: 42 ----------LGVDEENGFTPRYEIIQGKEEVVKRLKAAAKKAGTVYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ E++ ++ R+ FNEIT A+++A +LN + ++QQARR +DR+VGY +S Sbjct: 92 WHVAELLRPVNSNIRRIQFNEITARAVKEALENAQDLNQNLFDSQQARRILDRLVGYKIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWK + RG+SAGRVQSVA++L+VERE+E +AF +E+W + L++ Sbjct: 152 PILWKNVKRGISAGRVQSVALKLLVEREKERRAFKTDEYWPFKVLLEGGNPPPFWLELHK 211 Query: 241 QNDKPFRP-----VNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 + K +P + + +A LE +++V ++K P P+ITSTLQQ A+ Sbjct: 212 LSGKAVKPGVNHISTQAEAEALQQTLEAGQFTVDSVQEKQRKRDPLPPYITSTLQQDANR 271 Query: 296 RLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 R+G+ K+TM +AQRLYE ITYMRTDS ++++A R I D FG Sbjct: 272 RMGYSAKRTMSVAQRLYEGVELGRHGTTALITYMRTDSVRIAKEAQEAARELIIDRFGAD 331 Query: 347 YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTP 405 Y P P + +K +Q+AHEAIRP DV + + +K + ++ KLY+LIW++FVA QM Sbjct: 332 YYPSKPRNFKTKGGAQDAHEAIRPVDVTITPDDVKSSLPSEQHKLYRLIWQRFVASQMAA 391 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELT 465 A + TT+ V A +A+G L F G+ M E LP + +G+ L L EL Sbjct: 392 ASFWDTTVLVSAPATEWRAKGERLLFPGFLAAMDKSGTEAETE-LPKLVEGETLRLNELK 450 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 Q FT+PP R+SEASLVK LE+ GIGRPSTYA+IIST+ DR Y R E +RF ++G Sbjct: 451 KEQKFTQPPPRYSEASLVKTLEELGIGRPSTYAAIISTLLDREYARQEEKRFVPTELGFT 510 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 V+D+L E+F LM+ FTAQME+ LD VA + +W +L F DF L+KA + Sbjct: 511 VSDQLSEHFHALMDVGFTAQMESLLDDVAAGKQDWAKLLKDFGHDFYPTLEKARTEM--- 567 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV-PENEVLN 644 T I C CG+ M I+ TG FLGC+G+ C+T N EN + Sbjct: 568 ---ARSQQETDIVCENCGKPMSIKFGKTGEFLGCTGFPT-----CRTIKNFTRDENGAIR 619 Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGY----EIEEGEFR 700 ++E E E + C KCG M + C P C E G Sbjct: 620 IVERETPEETGVE----CEKCGKPMAIKQSRRG-EFLGCTGYPDCKNIVNFQRDENGAIS 674 Query: 701 IKGYDGP--IVECEKCGSEMHLKMGRFG-KYMACTN-EECKNTRKILRNGEVAPPKEDPV 756 + + + C CG E+ LK R G +++AC+N +C A P V Sbjct: 675 VIESEKLQVVGSCPDCGGELLLKKARTGSRFIACSNYPDCTY----------AAPFSTGV 724 Query: 757 PLPELPCEKSDAYFVLRDGAAGV-FLAANTFPKSRET 792 P P C V + G F + + +PK Sbjct: 725 PCPVEGCA---GELVEKSSRRGKIFFSCSAYPKCDYA 758 Score = 102 bits (255), Expect = 4e-20, Method: Composition-based stats. Identities = 25/120 (20%), Positives = 45/120 (37%), Gaps = 3/120 (2%) Query: 702 KGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKI--LRNGEVAPPKEDPVPL 758 + + CE CG M +K G+ G+++ CT C+ + NG + + + Sbjct: 569 RSQQETDIVCENCGKPMSIKFGKTGEFLGCTGFPTCRTIKNFTRDENGAIRIVERETPEE 628 Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAP 818 + CEK ++ G FL +P + +E EKL+ + P Sbjct: 629 TGVECEKCGKPMAIKQSRRGEFLGCTGYPDCKNIVNFQRDENGAISVIESEKLQVVGSCP 688 >UniRef50_B0MRI8 DNA topoisomerase n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MRI8_9FIRM Length = 713 Score = 713 bits (1841), Expect = 0.0, Method: Composition-based stats. Identities = 303/757 (40%), Positives = 424/757 (56%), Gaps = 78/757 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKAKTI KYLG DY V +SVGHIRDLP S Sbjct: 18 LVIVESPAKAKTIEKYLGKDYSVVASVGHIRDLPKS------------------------ 53 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 ++GVD +N+E YE K ++ ELK+ A+ +D +YLATD DREGEAI+WHL Sbjct: 54 -----KLGVDVDNNFEPKYENKKDKAALIKELKKDAKASDIVYLATDPDREGEAISWHLA 108 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 V+G RV F+EITK+ I + P L++D +NAQQARR +DR+VGY +SP LW Sbjct: 109 HVLGISPDAPVRVTFSEITKSGIEAGMSHPRTLDMDLINAQQARRILDRIVGYKLSPFLW 168 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS-TTTPSGEALALQVTHQND 243 KK+ RGLSAGRVQSVAVRL+V+RE+EI++F +E+W +DA + S A ++T Sbjct: 169 KKVRRGLSAGRVQSVAVRLIVDREQEIESFEAQEYWSIDAKLLSASSRRAFPAKLTEVKG 228 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 + F+ +NKE+T +++LE + + ++ P PF TSTLQQ AS +L F ++ Sbjct: 229 EKFKALNKEETDKVLAMLENGEFIITNIKNSTRKKTPAPPFTTSTLQQEASRKLSFNARR 288 Query: 304 TMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 TM AQ LYE G ITYMRTDS +S +A I +GK+YLP P Sbjct: 289 TMKAAQELYEGVEIPDMGAVGIITYMRTDSLRISDEAKAAAAQMIESTYGKEYLPSKPRV 348 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 + SK N+Q+AHEAIRP+ + + E +K + D KLY+LIW +F+A QM D+ + Sbjct: 349 FKSKNNAQDAHEAIRPTIITLTPEKVKSALSGDQYKLYKLIWERFMASQMENQLLDTKAV 408 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR--ILPAVNKGDALTLVELTPAQHFT 471 + G+ KA G ++FDG+TK+ + DE+ LPA+ G+ L + ELT QHFT Sbjct: 409 DITCGECLFKANGYTVKFDGFTKLYEESKDNDEEEGGALPALEVGEKLKVKELTGNQHFT 468 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 +PP R++EASL+K LE+ GIGRPSTYA I+TI DR YV E ++ +G ++TD ++ Sbjct: 469 QPPPRYTEASLIKALEENGIGRPSTYAPTIATILDRHYVEREAKQLKPTSLGIVITDLMK 528 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 +F +++ FTAQME+ LD++ +A+W VL F++ F + L KAEKD E ++ Sbjct: 529 GHFERIVDAKFTAQMESDLDKIEAGKADWVDVLGKFYTGFDKMLTKAEKDMEGKRVKIPD 588 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 T I C CG+ M I+ G FLGCSG+ CK T +V E L Sbjct: 589 EP-TDIVCDKCGKPMVIKIGPYGKFLGCSGFP-----ECKNTKRIVNETGGL-------- 634 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV-E 710 CP CG M + + C N C+ +D P+ + Sbjct: 635 ----------CPHCGGKMLAKKSKKGKPFFGCENYKDCNF----------MTWDTPLEDK 674 Query: 711 CEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGE 747 C KCGS + K+G+ G+ + C + C R + + Sbjct: 675 CPKCGSTLFKKVGKQGQ-VYCAKDGCGYVRPADEDKK 710 Score = 80.9 bits (198), Expect = 2e-13, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 41/114 (35%), Gaps = 15/114 (13%) Query: 678 RKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EEC 736 K + + + EG+ + + C+KCG M +K+G +GK++ C+ EC Sbjct: 562 GKFYTGFDKMLTKAEKDMEGKRVKIPDEPTDIVCDKCGKPMVIKIGPYGKFLGCSGFPEC 621 Query: 737 KNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG-VFLAANTFPKS 789 KNT++I V C + + G F + Sbjct: 622 KNTKRI-------------VNETGGLCPHCGGKMLAKKSKKGKPFFGCENYKDC 662 Score = 65.9 bits (159), Expect = 6e-09, Method: Composition-based stats. Identities = 12/44 (27%), Positives = 22/44 (50%) Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVE 798 P ++ C+K V++ G G FL + FP+ + T+ + E Sbjct: 587 PDEPTDIVCDKCGKPMVIKIGPYGKFLGCSGFPECKNTKRIVNE 630 >UniRef50_B5EJ79 DNA topoisomerase n=61 Tax=Proteobacteria RepID=B5EJ79_ACIF5 Length = 851 Score = 713 bits (1840), Expect = 0.0, Method: Composition-based stats. Identities = 301/812 (37%), Positives = 415/812 (51%), Gaps = 99/812 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG D+ V +S GH+RDL Sbjct: 1 MAHQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDL----------------------- 37 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VD H++ Y + E+ V + + AD ++LATD DREGEAI+ Sbjct: 38 ------QPKEGAVDTEHDFAMRYTPIERNERHVDAIAKALRGADKLWLATDPDREGEAIS 91 Query: 121 WHLREVIGGD----DARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WHL E++ D RVVF+EITK A+++A P E+ +D VNAQQARR +D +VG Sbjct: 92 WHLVELLRERQLLGDKPTQRVVFHEITKKAVQEAIAHPREIAMDLVNAQQARRALDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 + +SPLLW+K+ GLSAGRVQS A+RL+ ERE EI+AFV E+W + + Sbjct: 152 FNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASRLQHAGSAFTGR 211 Query: 237 QVTHQNDK--PFRPVNKEQTQAA----VSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 QN K F + +Q QA L + V E E K +P APF TSTLQ Sbjct: 212 LTHWQNKKLEQFDIADGDQAQAIRSGMEDDLGRQALRVREVERKSRQRQPAAPFTTSTLQ 271 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 Q AS +LGF +TM +AQ+LYE G I+YMRTD+ NL+++A+ +R +I Sbjct: 272 QEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRTFIDGY 331 Query: 343 FGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVA 400 +G +++PE+P +Y +K +N+QEAHEAIRP+D+ ESL+ +E D +LY L+W++ +A Sbjct: 332 YGSEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPESLQGVLERDLWRLYDLVWKRSIA 391 Query: 401 CQMTPAKYDSTTLTVGAGDF-RLKARGRILRFDGWTKVMPALR----KGDEDRILPAVNK 455 CQM PA+ D + + AG L+A G + F G+ V + + + +RILP ++ Sbjct: 392 CQMAPARLDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDESNRILPPLDV 451 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 GD ++ + P QHFT+PP R+S+A+LVK LE GIGRPSTYASII T+Q+R YV VE R Sbjct: 452 GDEPLVLGIDPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAVEQR 511 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 RF+ +G +V L +F ++Y FTA ME+ LD V+ E +W+ VL F+S F L Sbjct: 512 RFHPTDLGRVVGRFLINHFERYVDYGFTASMEDELDAVSRGEKQWQPVLSAFWSPFRALL 571 Query: 576 D-KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTI 634 D KA E + CP CG+ + +R G F+ CSGY C T Sbjct: 572 DEKANVSRAEATSEALEEA-----CPQCGKPLFLRLGRHGRFVACSGYP-----ECNYTR 621 Query: 635 NLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEI 694 + + A R CP CG + Y + C P C E Sbjct: 622 PV------------DGPREPAEPVGRDCPDCGKPLV-YKTGRYGRFISCSGYPECKHIEP 668 Query: 695 EEGEFRIKGYDGPIVECEKCG-SEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKE 753 V C +CG E+ K R+GK N K T + PP Sbjct: 669 LTQPK------SSGVTCPQCGEGELVEKRSRYGKVFYSCNTYPKCTYAVW-----GPPVA 717 Query: 754 DPVPLPELPCEKSDAY-FVLRDGAA-GVFLAA 783 P C + + + G G LA Sbjct: 718 RP-------CPRCGWPIMIEKSGKRLGEQLAC 742 Score = 119 bits (297), Expect = 6e-25, Method: Composition-based stats. Identities = 31/142 (21%), Positives = 54/142 (38%), Gaps = 17/142 (11%) Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710 AE + + CP+CG + L R C P C+ +G + + Sbjct: 580 AEATSEALEEACPQCGKPLFLRLGRHGR-FVACSGYPECNYTRPVDGPRE--PAEPVGRD 636 Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD-A 768 C CG + K GR+G++++C+ ECK+ + + + C + Sbjct: 637 CPDCGKPLVYKTGRYGRFISCSGYPECKHIEPLTQ-----------PKSSGVTCPQCGEG 685 Query: 769 YFVLRDGAAGV-FLAANTFPKS 789 V + G F + NT+PK Sbjct: 686 ELVEKRSRYGKVFYSCNTYPKC 707 Score = 100 bits (248), Expect = 3e-19, Method: Composition-based stats. Identities = 22/85 (25%), Positives = 38/85 (44%), Gaps = 8/85 (9%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD 767 C +CG + L++GR G+++AC+ EC TR + E A P C Sbjct: 589 EACPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVDGPREPAEPVGRD-------CPDCG 641 Query: 768 AYFVLRDGAAGVFLAANTFPKSRET 792 V + G G F++ + +P+ + Sbjct: 642 KPLVYKTGRYGRFISCSGYPECKHI 666 Score = 60.1 bits (144), Expect = 4e-07, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 20/54 (37%) Query: 740 RKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 R +L E E C + LR G G F+A + +P+ TR Sbjct: 568 RALLDEKANVSRAEATSEALEEACPQCGKPLFLRLGRHGRFVACSGYPECNYTR 621 >UniRef50_C9LSJ2 DNA topoisomerase n=3 Tax=Veillonellaceae RepID=C9LSJ2_9FIRM Length = 836 Score = 712 bits (1838), Expect = 0.0, Method: Composition-based stats. Identities = 304/765 (39%), Positives = 442/765 (57%), Gaps = 77/765 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 + LV+VESPAKAKTI KYLG Y+V++S+GH+RDLP S Sbjct: 115 PQTLVVVESPAKAKTIEKYLGKKYMVRASMGHLRDLPKS--------------------- 153 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + G+D +++ Y + GK ++ LK+ A+ A +YLA+D DREGEAIAW Sbjct: 154 --------QFGIDVENDFAPKYINIRGKGDLIKALKKDAKHAAKVYLASDPDREGEAIAW 205 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL ++G D R+VFNEITK AI+ A +P +N+DRV+AQQARR +DR+VGY +SP Sbjct: 206 HLAHILGIDPNENCRIVFNEITKPAIQAAVKEPYPINLDRVDAQQARRMLDRIVGYKLSP 265 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLW+KI +GLSAGRVQSV V+L+ +RE+EI+AFVPEE+W V G A ++ Sbjct: 266 LLWRKIKKGLSAGRVQSVTVKLICDREKEIQAFVPEEYWTVGMKLKKGRGAQFAAELATV 325 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + K +KE+T A V + K +SV E + + P APF TS++QQ AS +LGF Sbjct: 326 DGKKLALHSKEETSALVKDMAKQSFSVKEVKKRERRRNPVAPFTTSSMQQDASRKLGFTS 385 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 ++TMM+AQ+LYE G ITYMRTDST LS A++ VRGY+ +FG YLPE P Sbjct: 386 RRTMMIAQQLYEGVELGRRGPVGLITYMRTDSTRLSDLALDEVRGYVGTSFGADYLPEKP 445 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 N YA+ + +Q+AHEAIRP+ V E ++ + + +LY LIW++FVA QMTPA +D+ Sbjct: 446 NIYAAGKKAQDAHEAIRPTSVENTPELMEKYLSREQLRLYTLIWQRFVASQMTPAVFDTV 505 Query: 412 TLTVGAGD-FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 +++V AG+ + +A G L+F G+ V A K ++D +LP + G+AL+L++L P QHF Sbjct: 506 SVSVAAGERYIARASGSTLKFPGFLAVY-ADNKKEKDVLLPELAAGEALSLLDLLPEQHF 564 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP R++EASLVK LE+ IGRPSTYA II TI RGYV +++ F +G +V D L Sbjct: 565 TEPPPRYNEASLVKTLEEEDIGRPSTYAPIIETILARGYVVRQDKHFQPTDLGFLVNDML 624 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 EE+F+++++ FTA +EN LD++A + + +L F+ F + L++A++ E + Sbjct: 625 EEHFKDIVDVQFTAGLENELDEIAEGKVDKNDLLRGFYEPFEKTLEEADEAIGEVEI--- 681 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 ++ + C CGR M ++ G FL C G+ C+ T L+ + V Sbjct: 682 PEEVSDVICEKCGRNMVVKQGRYGKFLACPGFP-----DCRNTKPLLKDTGV-------- 728 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710 CPKCG + + + C N P CD + + Sbjct: 729 ----------PCPKCGGRIVERRSRRGQAFYGCENYPACDY---------VTWDQPLTEK 769 Query: 711 CEKCGSEMHLKMGRFGKYM-ACTNEECKNTRKILRNGEVAPPKED 754 C +CG+ M + G+ + C+NEECK N E+ + Sbjct: 770 CPECGAFMLRHRYKNGRILPYCSNEECKTRIDHPINKEIEKSRAR 814 Score = 90.2 bits (222), Expect = 3e-16, Method: Composition-based stats. Identities = 26/90 (28%), Positives = 39/90 (43%), Gaps = 15/90 (16%) Query: 702 KGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPE 760 + V CEKCG M +K GR+GK++AC +C+NT+ +L++ Sbjct: 681 IPEEVSDVICEKCGRNMVVKQGRYGKFLACPGFPDCRNTKPLLKD-------------TG 727 Query: 761 LPCEKSDAYFVLRDGAAG-VFLAANTFPKS 789 +PC K V R G F +P Sbjct: 728 VPCPKCGGRIVERRSRRGQAFYGCENYPAC 757 Score = 65.9 bits (159), Expect = 7e-09, Method: Composition-based stats. Identities = 16/56 (28%), Positives = 24/56 (42%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 + + E E P + ++ CEK V++ G G FLA FP R T+ Sbjct: 665 FEKTLEEADEAIGEVEIPEEVSDVICEKCGRNMVVKQGRYGKFLACPGFPDCRNTK 720 >UniRef50_A3EPL6 DNA topoisomerase n=2 Tax=Leptospirillum sp. Group II RepID=A3EPL6_9BACT Length = 850 Score = 712 bits (1838), Expect = 0.0, Method: Composition-based stats. Identities = 304/816 (37%), Positives = 426/816 (52%), Gaps = 87/816 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L+IVESP KA+T++K LGS Y+VK+SVGH++DLP Sbjct: 49 GKTLIIVESPTKARTLSKVLGSGYLVKASVGHVKDLP----------------------- 85 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +R+G+D H++ +EV P K+KV+SE++ A A +YLA+D DREGEAIA+ Sbjct: 86 ------PSRLGIDVDHDFALEFEVHPDKKKVLSEIRSEARSAREVYLASDPDREGEAIAY 139 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ + RV+F+E+T+ IR A ++PGE+++ +V AQ+ARR +DR+VGY +SP Sbjct: 140 HIASELEALPVPPKRVLFHELTEGGIRSALSEPGEIDVRKVEAQKARRALDRIVGYTISP 199 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE---ALALQV 238 LLW ++ RGLSAGRVQSVAVRLV +RE EI FV EE+W +DA ++ Sbjct: 200 LLWDRVRRGLSAGRVQSVAVRLVCDREDEIARFVREEYWTIDARFRPGDPRVPPTFLSRL 259 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 + + + AV + + R++V E P P TS LQQ A+ RL Sbjct: 260 DRVSGEKPVLPDARTAGQAVERIRRERFTVGEITRADKKRNPSPPLTTSRLQQEAANRLR 319 Query: 299 FGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 F KKTM +AQ+LYE G ITYMRTDS +S +A R +I + LP Sbjct: 320 FSAKKTMTVAQKLYEGVDLPGQGPVGLITYMRTDSVRVSPEAAEAARSWIRQHH-PDGLP 378 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKY 408 Y +++ Q+AHEAIRPSDV ESL+ ++ D +LY LIW+ FV QM+PA Y Sbjct: 379 ARAPAYKNRKGIQDAHEAIRPSDVRRTPESLQGSIDPDLFRLYDLIWKSFVESQMSPALY 438 Query: 409 DSTTLTVGA-GDFRLKARGRILRFDGWTKV--------MPALRKGDEDRILPAVNKGDAL 459 TT+ V +A GR+L+ G+ + A EDR+LP + G+ + Sbjct: 439 LQTTVLVEGDQGDVFRASGRVLKSPGFLALRGLSVAPEDGAGEGEGEDRLLPPLETGEIV 498 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 +L E+TP QHFT+PP R+SEASL++ELE++GIGRPSTYA+I+STIQDR YV + RFY Sbjct: 499 SLEEVTPDQHFTEPPPRYSEASLIRELEEKGIGRPSTYATILSTIQDREYVEKKENRFYP 558 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 +G+ V L E+F +LM+ FTA+ME LDQV E ++ V+ F++ F +++KA+ Sbjct: 559 TDLGKAVNSLLVESFPDLMSVRFTARMEEELDQVEEGERGYRDVVGDFYTPFHHEVEKAK 618 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPE 639 K + V T + CP C M + G +L CS Y CKTT N E Sbjct: 619 KGGMTNLKKL--EVPTDVSCPVCQAPMNRKWGKNGSYLSCSRYP-----ECKTTRNFTEE 671 Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEI----- 694 N + ++E E C C M C P C Sbjct: 672 NGQIRIVEEALPEGEV------CHVCQAPMVI-KKGRFGTFLACSRYPECKTTRPWPPKA 724 Query: 695 EEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKE 753 E + + P+ C +C S M K GRFG + AC+ ECK TR + Sbjct: 725 EASLPAVSPAEAPV--CPECSSPMVQKRGRFGSFWACSRYPECKGTRPL--------ATG 774 Query: 754 DPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKS 789 P P+ V R G G F + +P+ Sbjct: 775 HPCPVKG-----CKGELVPRRGKRGTFYGCSRYPEC 805 >UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5D2W4_PELTS Length = 714 Score = 712 bits (1837), Expect = 0.0, Method: Composition-based stats. Identities = 295/758 (38%), Positives = 426/758 (56%), Gaps = 83/758 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI+K+LG + VK+S+GH+RDLP S Sbjct: 1 MSKTLVIVESPAKAKTISKFLGKKFTVKASMGHVRDLPKS-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + GVD + ++ Y + GK ++ +L+ +KAD + +A+D DREGEAIA Sbjct: 41 ---------QFGVDVKNGFKPKYITIRGKGDIIKDLRAAVKKADQVLIASDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+ ++ D+ R+ FNEITK AI++A P ++ +RVNAQQARR +DR+VGY +S Sbjct: 92 WHLQNLLEIDENESCRIEFNEITKQAIQKALQHPRPIDRNRVNAQQARRILDRLVGYNLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLW+KI +GLSAGRVQSVAVRL+ +RE EI++FVPEE+W + AS ++ Sbjct: 152 PLLWRKIKKGLSAGRVQSVAVRLICDREEEIQSFVPEEYWTLVASFVKTGEAPFEGRLIK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 D+ +KE+ Q + L+ ARY+V + K + KP PFITSTLQQ A +L F Sbjct: 212 FRDEKIDIPSKEKMQEVLENLKGARYTVEKVTRKEKSRKPPLPFITSTLQQEAYRKLNFT 271 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 +KTMM+AQ+LYE G ITY+RTDST +S A + YI + FG +Y Sbjct: 272 ARKTMMVAQQLYEGLDLGREGTSGLITYIRTDSTRVSASAREEAQKYIVERFGARYAGRE 331 Query: 352 PNQY---ASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 K Q+AHEAIRP+ V E +K+ + D KLY+LIW +F+A QM PA Sbjct: 332 TPPVGPAGRKGKIQDAHEAIRPTSVQREPEQVKEYLTGDQYKLYKLIWSRFLASQMKPAV 391 Query: 408 YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG---DEDRILPAVNKGDALTLVEL 464 +D+T + + AG++ +A G +++F G+ KV R +E+++LP + +G+ + L Sbjct: 392 FDTTNIDIKAGEYLFRANGSVMKFPGFMKVYTESRDDEEKEEEKLLPELKEGEEIEARSL 451 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 TP QHFT+PP R+++ASLV+ LE++GIGRPSTYA I+ TI RGYV EN++F+ ++G Sbjct: 452 TPRQHFTQPPPRYTDASLVRALEEKGIGRPSTYAPIVETILKRGYVVRENKQFFPTELGM 511 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 IV D L+++F+E+++ DFTA ME SLD + E +W VL+ F+ F L+KAE E Sbjct: 512 IVVDLLKKHFKEIIDIDFTAGMEESLDSIEEGELDWIKVLESFYGPFKNTLEKAE---NE 568 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 G +T C CGR M ++ G FL C G+ C++T L+ Sbjct: 569 IGHVQVAEEVTEEKCDRCGRSMVVKVGRYGKFLACPGFP-----ECRSTKPLLEPVGA-- 621 Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 +CP+C + RK C N P C+ + Sbjct: 622 ----------------KCPRCEGELVVRRTKKGRKFLGCSNFPECEF---------VTWD 656 Query: 705 DGPIVECEKCGSEMHLKM--GRFGKYMACTNEECKNTR 740 +C +CG M K G+ G ++ C +E+C + Sbjct: 657 QPSGTKCPECGGLMVEKKNAGKKG-FLQCVSEDCGYKK 693 Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats. Identities = 25/87 (28%), Positives = 44/87 (50%), Gaps = 15/87 (17%) Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPC 763 + +C++CG M +K+GR+GK++AC EC++T+ +L +PV C Sbjct: 577 EVTEEKCDRCGRSMVVKVGRYGKFLACPGFPECRSTKPLL----------EPV---GAKC 623 Query: 764 EKSDAYFVLRDGAAG-VFLAANTFPKS 789 + + V+R G FL + FP+ Sbjct: 624 PRCEGELVVRRTKKGRKFLGCSNFPEC 650 Score = 57.8 bits (138), Expect = 2e-06, Method: Composition-based stats. Identities = 15/42 (35%), Positives = 23/42 (54%), Gaps = 1/42 (2%) Query: 757 PLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVE 798 + E C++ V++ G G FLA FP+ R T+ PL+E Sbjct: 577 EVTEEKCDRCGRSMVVKVGRYGKFLACPGFPECRSTK-PLLE 617 >UniRef50_C6BUQ9 DNA topoisomerase n=14 Tax=Desulfovibrionales RepID=C6BUQ9_DESAD Length = 800 Score = 712 bits (1837), Expect = 0.0, Method: Composition-based stats. Identities = 306/813 (37%), Positives = 453/813 (55%), Gaps = 80/813 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L++VESPAK KTI+K+LG +Y V +SVGH+RDLP Sbjct: 1 MSKDLIVVESPAKVKTISKFLGRNYQVAASVGHVRDLPK--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 N++GV+ ++ Y+V+PGKE VV++LK+ A KADH++LA D DREGEAI Sbjct: 40 --------NKLGVEENGDFTPQYQVIPGKEDVVNKLKKAAAKADHVFLAPDPDREGEAIG 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ +I + SR+ FNEIT A+++A P LN ++QQARR +DR+VGY +S Sbjct: 92 WHVAAIIKEVNENVSRIQFNEITARAVKEALEHPQPLNEQLFDSQQARRILDRLVGYKIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ RG+SAGRVQSVA++LVVERE+ +AF+PEE+W A + + Sbjct: 152 PILWKKVKRGISAGRVQSVALKLVVEREKARRAFIPEEYWLFKAHVEGKNPPPFIADLWK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + K + ++ +A S ++ + + + +K P P+ITSTLQQ A+ RLG+ Sbjct: 212 VDGKKAEIGSADEAEALQSNVKGVPFEITDLTEKERKRNPLPPYITSTLQQDANRRLGYS 271 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 K+TM +AQRLYE ITYMRTDS ++ +A + + I D +G ++ P Sbjct: 272 AKRTMTLAQRLYEGVELGDKGTTALITYMRTDSVRIANEARDTAKKVILDKYGDEFYPAK 331 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 P Y SK +Q+AHEAIRP D +++ E +K + AD K+Y+LIW +F+A QM PA++ Sbjct: 332 PQVYKSKGGAQDAHEAIRPVDASILPEDVKPYLPADQFKVYKLIWNRFIASQMAPARFWD 391 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI-LPAVNKGDALTLVELTPAQH 469 T +T+ A + +++G L F G+ +V + GDE I LP + KG+ L + ++ Q Sbjct: 392 TVVTIQAKNTIWRSKGERLLFPGFMRV--TGKTGDEKLIELPKLEKGEVLKVDKIESEQK 449 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FT+PPAR+SEASLV+ELE++GIGRPSTYASIISTIQDRGYV +E ++F ++G +V+D+ Sbjct: 450 FTQPPARYSEASLVRELEEKGIGRPSTYASIISTIQDRGYVNLEEKKFIPTELGFVVSDQ 509 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 L E+F+ELM+ FTA ME LD VA+ + EW +++ F F L+ A K+ + GG Sbjct: 510 LSEHFKELMDVGFTAAMEKQLDDVADGKIEWTSLMKDFVDGFYPTLETAAKEMKRGGED- 568 Query: 590 NQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE 649 T I C C M I+ TG FLGCS Y CK +N + + V+ Sbjct: 569 -----TGITCDKCESPMVIKFGRTGEFLGCSNYP-----ECKNIVNFTRDEKGKIVV--- 615 Query: 650 DAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC----DGYEIEEGEFRIKGYD 705 E C KCG+AM + + C P C + +EG+ ++ Sbjct: 616 LEEEPPEETGVTCEKCGSAMAIKRSNRG-EFLGCTGYPDCRNIKNFERDDEGKIKVVETP 674 Query: 706 GP--IVECEKC-GSEMHLKMGRFG-KYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPE 760 + +C C ++ +K R G +++AC+N +CK+ + P V P Sbjct: 675 TAQIVGKCPDCDDGDLIIKHARTGSRFIACSNYPDCKHAK----------PFSTGVKCPR 724 Query: 761 LPCEKSDAYFVLRDGAAGV-FLAANTFPKSRET 792 C+ V + G F + + +P Sbjct: 725 EGCK---GELVEKSSRRGKLFYSCDQYPDCDYA 754 Score = 107 bits (267), Expect = 2e-21, Method: Composition-based stats. Identities = 34/156 (21%), Positives = 59/156 (37%), Gaps = 12/156 (7%) Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDG----YEIEEGEFRIKGY 704 ++ + C KC + M + C N P C E+G+ + Sbjct: 560 KEMKRGGEDTGITCDKCESPMVI-KFGRTGEFLGCSNYPECKNIVNFTRDEKGKIVVLEE 618 Query: 705 DG---PIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVA-PPKEDPVPLP 759 + V CEKCGS M +K G+++ CT +C+N + R+ E E P Sbjct: 619 EPPEETGVTCEKCGSAMAIKRSNRGEFLGCTGYPDCRNIKNFERDDEGKIKVVETPTAQI 678 Query: 760 ELPCEKSD-AYFVLRDGAAG-VFLAANTFPKSRETR 793 C D +++ G F+A + +P + + Sbjct: 679 VGKCPDCDDGDLIIKHARTGSRFIACSNYPDCKHAK 714 Score = 101 bits (252), Expect = 1e-19, Method: Composition-based stats. Identities = 31/111 (27%), Positives = 52/111 (46%), Gaps = 7/111 (6%) Query: 686 NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILR 744 PT + E +G + + C+KC S M +K GR G+++ C+N ECKN R Sbjct: 552 YPTLETAAKEMK----RGGEDTGITCDKCESPMVIKFGRTGEFLGCSNYPECKNIVNFTR 607 Query: 745 N--GEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 + G++ +E+P + CEK + ++ G FL +P R + Sbjct: 608 DEKGKIVVLEEEPPEETGVTCEKCGSAMAIKRSNRGEFLGCTGYPDCRNIK 658 >UniRef50_B9L0B0 DNA topoisomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0B0_THERP Length = 744 Score = 711 bits (1836), Expect = 0.0, Method: Composition-based stats. Identities = 291/766 (37%), Positives = 417/766 (54%), Gaps = 95/766 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ALVIVESPAKA+TI ++LG Y VK+S+GH+RDLP S Sbjct: 34 GQALVIVESPAKARTIARFLGPGYTVKASMGHVRDLPKS--------------------- 72 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++GVD N++ Y VL K VV EL++ ++A + LATD DREGEAIAW Sbjct: 73 --------KLGVDVAQNFQPTYTVLKEKLPVVKELQESVQRARELILATDPDREGEAIAW 124 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL E D R+VF+EIT+ AIR+A P +++ VNAQQARR +DR+VGY +SP Sbjct: 125 HLIEATRAHDKPVRRIVFHEITEEAIREALAHPRGIDMRLVNAQQARRVLDRLVGYEISP 184 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA-----LAL 236 LLW+K+ GLSAGRVQSVA+RLVV+REREI+AFVP+E+W ++ A A Sbjct: 185 LLWRKVKSGLSAGRVQSVALRLVVDREREIQAFVPQEYWTIEVDLVPTGNGAQEPVPFAA 244 Query: 237 QVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 + + N+E +A LE ++Y V+ +++ +P PFITSTLQQ A + Sbjct: 245 ALVRVRGEKPDLPNEEAARAVARELEASQYWVVSIKERQKQRRPAPPFITSTLQQEAGRK 304 Query: 297 LGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 L F V TM +AQ+LYE G ITYMRTDST ++ A R I+ +G + Sbjct: 305 LRFPVSLTMQLAQQLYEGVELGPEGSVGLITYMRTDSTQVAASAQQRAREVIAARWGADF 364 Query: 348 LPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTP 405 LPE P YA K + +QEAHEAIRP+D ES++ + +LY+LIW +F+A QM P Sbjct: 365 LPERPPVYAKKAKGAQEAHEAIRPTDPARDPESVRPYLTPRQYQLYRLIWERFIASQMAP 424 Query: 406 AKYDSTTLTVGAG-------DFRLKARGRILRFDGWTKVM-----PALRKGDEDRILPAV 453 A YD+ T+ + AG + L+A G ++RF G+ V + R LP + Sbjct: 425 AIYDTVTVEIAAGPTVGADAPYLLRATGSVVRFPGFLVVYREERDEDEVDELDQRPLPPL 484 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513 G+ L L+ + P QHFT+PP R+SEA+LVK LE+ GIGRPSTYA I T++ R YV VE Sbjct: 485 ATGEVLRLLAVRPEQHFTQPPPRYSEATLVKTLEELGIGRPSTYAPTIETLKQRRYVVVE 544 Query: 514 NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ 573 +R+ ++G +VTD L ++F ++++ FT+++E LD++A E +W V+ F+ F + Sbjct: 545 DRKLVPTELGMLVTDLLVQHFPDVVDVGFTSRLEEELDEIAAGERDWVPVVREFYEPFHR 604 Query: 574 QLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTT 633 Q+++AE+ E + + C CGR M I+ + G FL CSG+ CK Sbjct: 605 QVEEAEQTMERVRLADQ---PSGEVCELCGRPMVIKESRFGRFLSCSGFP-----ECKNK 656 Query: 634 INLVPENEVLNVLEGEDAETNALRAKRRCPKCGT-AMDSYLIDPKRKLHVCGNNPTCDGY 692 L+ + V RCP+CG + R + C P CD Sbjct: 657 RPLLEKIGV------------------RCPQCGEGEIVVRRSRKGRTFYGCSRYPDCDF- 697 Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKN 738 + C +CG + + + R + + C++ C Sbjct: 698 --------VSWERPTGERCPQCGGVLVVSVRRGQESVRCSS--CSY 733 Score = 87.8 bits (216), Expect = 2e-15, Method: Composition-based stats. Identities = 29/102 (28%), Positives = 43/102 (42%), Gaps = 17/102 (16%) Query: 692 YEIEEGEFRIKGYDGPIVE-CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVA 749 E E+ R++ D P E CE CG M +K RFG++++C+ ECKN R +L V Sbjct: 607 EEAEQTMERVRLADQPSGEVCELCGRPMVIKESRFGRFLSCSGFPECKNKRPLLEKIGVR 666 Query: 750 PPKEDPVPLPELPCEKSD-AYFVLRDGAAGV-FLAANTFPKS 789 C + V+R G F + +P Sbjct: 667 -------------CPQCGEGEIVVRRSRKGRTFYGCSRYPDC 695 Score = 74.4 bits (181), Expect = 2e-11, Method: Composition-based stats. Identities = 20/132 (15%), Positives = 37/132 (28%), Gaps = 26/132 (19%) Query: 658 AKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCG-S 716 + C CG M R C P C + ++ C +CG Sbjct: 623 SGEVCELCGRPMVIKESRFGR-FLSCSGFPECKNKRPLLEKIGVR--------CPQCGEG 673 Query: 717 EMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRD 774 E+ ++ R G+ + C+ +C GE C + V+ Sbjct: 674 EIVVRRSRKGRTFYGCSRYPDCDFVSWERPTGE--------------RCPQCGGVLVVSV 719 Query: 775 GAAGVFLAANTF 786 + ++ Sbjct: 720 RRGQESVRCSSC 731 Score = 62.0 bits (149), Expect = 9e-08, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 29/73 (39%), Gaps = 8/73 (10%) Query: 741 KILRNGEVAPPKEDPVPLPELP----CEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPL 796 R E A + V L + P CE V+++ G FL+ + FP+ + R Sbjct: 601 PFHRQVEEAEQTMERVRLADQPSGEVCELCGRPMVIKESRFGRFLSCSGFPECKNKRP-- 658 Query: 797 VEELYRFRDRLPE 809 L + R P+ Sbjct: 659 --LLEKIGVRCPQ 669 >UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8_PELCD Length = 841 Score = 707 bits (1824), Expect = 0.0, Method: Composition-based stats. Identities = 303/828 (36%), Positives = 427/828 (51%), Gaps = 99/828 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M ++LVIVESPAKAKTI K+LG Y V +S GH+R LP+ + Sbjct: 1 MAQSLVIVESPAKAKTIEKFLGPGYKVLASYGHVRALPSKQGS----------------- 43 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VD HN+ Y VLP +K + LK+ A+K+ + LATD DREGEAIA Sbjct: 44 ------------VDVEHNFSPLYHVLPESQKHIELLKKEAKKSRELILATDPDREGEAIA 91 Query: 121 WHLREVIGGDD----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WHL E +G D+ RV F+EITK AI++A +KPG + + V+AQQAR +D +VG Sbjct: 92 WHLLEALGIDENAKSPEVKRVTFHEITKGAIQEAISKPGHIARELVDAQQARSILDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 + +SP LWKKI GLSAGRVQSVA+RL+ ERE+EI+AF E+W ++ T G Sbjct: 152 FNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFEAREYWTIETRLATEQGSVFPA 211 Query: 237 QVTHQNDK---PFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAA 293 ++ + F + Q V + + V + + P APF TSTLQQ A Sbjct: 212 RLYAVDGNSLGKFDINQEAQALELVKAIGSEAFQVEKLKKTSKKRNPAAPFTTSTLQQEA 271 Query: 294 STRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 S +LGF +KTM +AQ+LYE G ITYMRTDS LSQ A R I+ +G+ Sbjct: 272 SRKLGFSARKTMTVAQKLYEGIDVGNGLEGLITYMRTDSVALSQVATGEARELITRMYGE 331 Query: 346 KYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQM 403 Y + P + +K +N+QEAHEA+RP+ ++ + + +K + +D KLY+LIW++ VA QM Sbjct: 332 DYALDKPRVFKNKAKNAQEAHEAVRPTSLSNLPDQIKAHLSSDQFKLYRLIWQRTVASQM 391 Query: 404 TPAKYDSTTLTVGAGD-FRLKARGRILRFDGWTKVMPALRKGDEDR------ILPAVNKG 456 A+ ++TT+ + AG+ F +A G+++RF G+ K+ DED+ LP + + Sbjct: 392 ATAQLEATTVDIRAGERFVFRASGQVVRFPGFMKLYIEDTDKDEDQDRQEEGTLPPLEQE 451 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 L E+ P+QHFT+PP RF+EASLVK LE+ GIGRPSTYASII+T+ R YVR+E R Sbjct: 452 QPLDCQEVQPSQHFTQPPPRFTEASLVKTLEEHGIGRPSTYASIINTLTTRKYVRLEKRA 511 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 FY E +G +V D L +F + ++YDFTAQ+E LD ++ E EW+ VL F+ F +L Sbjct: 512 FYTEDVGMVVNDLLVNHFNKYVDYDFTAQLEEDLDAISRGEREWQPVLKDFWEPFISRLK 571 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 + E + + + T CP CG+ + I+ +G FL CSG+ C+ T L Sbjct: 572 EKETQISKQDVTTEK---TDRICPECGKPLVIKLGRSGRFLACSGFP-----DCRYTEPL 623 Query: 637 VPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEE 696 + V+ + + C KCG M K C P C + Sbjct: 624 AGQEREEPVM-----------SDQTCEKCGAPMLIKQ-GRYGKFLACSAYPECKNIQPLV 671 Query: 697 GEFRIKGYDGPIVECEKCG-SEMHLKMGRFGKYMACTN--EECKNTRKILRNGEVAPPKE 753 + + C +CG E+ K R+GK N +CK L Sbjct: 672 KPKALG------ITCPQCGEGELMEKKSRYGKIFYSCNRYPKCKYALWDLP--------- 716 Query: 754 DPVPLPELPCEKSDAYFVLRDG--AAGVFLAANTFPKSRETRAPLVEE 799 E PC K V+ G F T + E Sbjct: 717 -----IEEPCPKCKFPLVVEKTTKRQGTFRKCPQ-EDCDWTVVLIPPE 758 >UniRef50_C1F6V0 DNA topoisomerase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F6V0_ACIC5 Length = 878 Score = 706 bits (1822), Expect = 0.0, Method: Composition-based stats. Identities = 309/832 (37%), Positives = 440/832 (52%), Gaps = 93/832 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+LVIVESPAKAKTINKYLG D+ V++S+GHI+DLP Sbjct: 1 MSKSLVIVESPAKAKTINKYLGKDFQVEASIGHIKDLPK--------------------- 39 Query: 61 KDERGALVNRMGVDPWH-NWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 N++GVD +E V+PGKEKVV +L++LA K D IYLA D DREGEAI Sbjct: 40 --------NKLGVDVEKGTFEPELIVIPGKEKVVDKLRKLATKVDTIYLAPDPDREGEAI 91 Query: 120 AWHLREVIGGDDAR---YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 A HL + + + R+ FNEIT A+ A + ++ + V+AQQ RR +DR+VG Sbjct: 92 AAHLEDELKAVVKKPEAIRRITFNEITPKAVTAALDHARSVDRNLVDAQQTRRVLDRIVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-EALA 235 Y +SPLLW K+ RGLSAGRVQ+VA+RL+VERE++IKAF P E+W +DA T + Sbjct: 152 YQISPLLWDKVRRGLSAGRVQTVALRLIVEREQQIKAFKPVEYWTIDAVLKTGGNPQEFT 211 Query: 236 LQVTHQNDKPFRPV--------NKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + + R +++ T V+ L KA +SV E E K APF TS Sbjct: 212 AHFIGIDGERARVETVDAPALPDQKLTDEVVAQLHKADWSVREVERKERKRNAPAPFTTS 271 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYI 339 LQQ AS +LGF VK+TM +AQRLYE G ITYMRTDST ++ +A+ VRGYI Sbjct: 272 KLQQDASRQLGFNVKRTMGVAQRLYEGIEIGGDAVGLITYMRTDSTRVAPEAIEAVRGYI 331 Query: 340 SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQF 398 GK YLP +PN + SK+++Q+AHEAIRP+D N+ + ++ + + KLY+LIWR+F Sbjct: 332 QKKVGKDYLPAAPNAFKSKKDAQDAHEAIRPADPNLHPDDIRKYLSDEQYKLYRLIWRRF 391 Query: 399 VACQMTPAKYDSTTLTVGAGD---FRLKARGRILRFDGWTKVMPALRKGDE------DRI 449 VA QM PA +D TT+ + A + + G +++FDG+ +V +++ + Sbjct: 392 VASQMMPAIFDQTTVEIAARADRRYDFRVTGSVMKFDGFLRVYEEVKEKKDADDEALANK 451 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 LPA+N GD L L L P QH+T+PP R++EASLVKELE+RGIGRPSTYA+II+TIQDR Y Sbjct: 452 LPALNNGDRLALSALKPEQHYTEPPPRYNEASLVKELEERGIGRPSTYATIINTIQDREY 511 Query: 510 VRV---ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 V+ RF ++G +VT L +NF + + +TA++E LD + + + W +L+ Sbjct: 512 VQKMGGRTGRFIPTEIGTVVTGLLVKNFPYIFDTKYTARLEEELDDIEDGKERWTDLLNG 571 Query: 567 FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPP 626 F+ F +L A + E+ T C CG + ++ G F CS Y Sbjct: 572 FYDHFEDELKDAATNMEDIK---RMEKPTDQKCDICGSPLVLKWGKFGSFYACSAYDKKK 628 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNN 686 K+ C T L E + CG M P C Sbjct: 629 KDGCTFTKENYEAKPNLAAPSDEAEQEEEYCEN-----CGRVMV-LRNGPWGPFMACPGY 682 Query: 687 ---PTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKI 742 P C + + K +C KCG ++ L+ G++G++++C+ +CK ++ Sbjct: 683 NEDPPCKTVRRLNQKQQQKPPQPLDEKCPKCGEQLVLRHGQYGEFISCSGYPKCKYIKQ- 741 Query: 743 LRNGEVAPPKEDPVPLPELPCEKSD-AYFVLRDGAAG-VFLAANTFPKSRET 792 + C + V + G F + +PK T Sbjct: 742 --------------NTIGMKCPQCKVGEIVEKKARRGNFFYGCSEYPKCDFT 779 Score = 98.6 bits (244), Expect = 8e-19, Method: Composition-based stats. Identities = 33/163 (20%), Positives = 56/163 (34%), Gaps = 20/163 (12%) Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPT-----CDGYEIEEGEFRIKG 703 ED + ++C CG+ + + C C + Sbjct: 588 EDIKRMEKPTDQKCDICGSPLV-LKWGKFGSFYACSAYDKKKKDGCTFTKENYEAKPNLA 646 Query: 704 YDG-----PIVECEKCGSEMHLKMGRFGKYMACTN----EECKNTRKILRNGEVAPPKED 754 CE CG M L+ G +G +MAC CK R++ + + PP+ Sbjct: 647 APSDEAEQEEEYCENCGRVMVLRNGPWGPFMACPGYNEDPPCKTVRRLNQKQQQKPPQP- 705 Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 + C K VLR G G F++ + +PK + + + Sbjct: 706 ----LDEKCPKCGEQLVLRHGQYGEFISCSGYPKCKYIKQNTI 744 Score = 64.3 bits (155), Expect = 2e-08, Method: Composition-based stats. Identities = 33/133 (24%), Positives = 48/133 (36%), Gaps = 16/133 (12%) Query: 596 SIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE------ 649 CP CG ++ +R G F+ CSGY + T P+ +V ++E + Sbjct: 707 DEKCPKCGEQLVLRHGQYGEFISCSGYPKCKYIKQNTIGMKCPQCKVGEIVEKKARRGNF 766 Query: 650 ----------DAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF 699 D N R+CP+CG+A VC NN E + Sbjct: 767 FYGCSEYPKCDFTANYKPVDRKCPECGSAYLMEKTLKSGVYLVCPNNKKPSAEEETTTKR 826 Query: 700 RIKGYDGPIVECE 712 + KG G V C Sbjct: 827 KKKGDTGEGVSCS 839 Score = 48.2 bits (113), Expect = 0.002, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 21/49 (42%) Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRL 807 + C+ + VL+ G G F A + + K ++ +E Y + L Sbjct: 597 TDQKCDICGSPLVLKWGKFGSFYACSAYDKKKKDGCTFTKENYEAKPNL 645 >UniRef50_D1C7I9 DNA topoisomerase n=8 Tax=Bacteria RepID=D1C7I9_SPHTD Length = 769 Score = 701 bits (1810), Expect = 0.0, Method: Composition-based stats. Identities = 290/767 (37%), Positives = 411/767 (53%), Gaps = 99/767 (12%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LVIVESPAKA+ I + LG Y VK+S+GH+RDLP S Sbjct: 61 TLVIVESPAKARNIGRILGRGYTVKASMGHVRDLPKS----------------------- 97 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 ++GV+ ++ Y + K KVV EL+ ++A I LATD DREGEAIAWHL Sbjct: 98 ------KLGVETDRDFAPVYLIPRDKSKVVKELRADVKEAREILLATDPDREGEAIAWHL 151 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 E D R+VF+EIT AIR+A P +++ V AQQARR +DR+VGY +SPLL Sbjct: 152 VEATDPGDKPVRRIVFHEITPEAIREALRNPRGIDMRLVEAQQARRILDRLVGYEISPLL 211 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG------EALALQ 237 W+K+ RGLSAGRVQSVA+RLVVEREREI+ FVP+E+W +DA + Sbjct: 212 WRKVKRGLSAGRVQSVALRLVVEREREIQNFVPQEYWTLDAELAKREAVNGRKPKPFVAS 271 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 ++ N + ++ T A V L+ A + V++ E K T +P PF TSTLQQ AS +L Sbjct: 272 LSRVNGQKPDLKDEASTMAIVRALDGAEFQVVKVEVKETQRRPAPPFTTSTLQQEASRKL 331 Query: 298 GFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 V++TM +AQ LYE G ITYMRTDSTN++ A R I++ +G ++L Sbjct: 332 NMPVRRTMQIAQELYEGIDLGDAGTVGLITYMRTDSTNVAASAQARAREVIAERYGPEFL 391 Query: 349 PESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDM----EADAQKLYQLIWRQFVACQM 403 P+ P Y K + +QEAHEAIRP+D ES+K + KLY+LIW++F+A Q Sbjct: 392 PDRPPVYTRKAKGAQEAHEAIRPTDPARDPESIKAFLGGASSPRYKLYRLIWQRFIASQT 451 Query: 404 TPAKYDSTTLTVGAG------DFRLKARGRILRFDGWTKVMPALRKGD-----EDRILPA 452 A +DST + + AG +R +A G +++F G+ + R D + LP Sbjct: 452 RNAVFDSTAVDIDAGPPGGPKPYRFRATGSVIKFPGFLAIYREGRDDDTVDEIDREALPP 511 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 + +G+ L LV L P QHFT+PP RF+EA+LVK LE+ GIGRPSTYA I+T+Q R YV V Sbjct: 512 LTEGEVLDLVRLLPEQHFTQPPPRFTEATLVKALEELGIGRPSTYAPTIATLQARNYVTV 571 Query: 513 ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 E RR Y ++G +V D L ++F ++++ +FT+++E+ LDQ+A+ E W ++ F+ F Sbjct: 572 EQRRLYPTELGTVVNDLLVQHFPDIVDVNFTSKLEDELDQIASGEQSWVPMVRAFYGPFH 631 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKT 632 + +++AEK E G T C CGR M I+ G FL CSG+ C+ Sbjct: 632 ETVERAEK---EIGRVKVADEPTDEVCEKCGRPMVIKLGRYGRFLACSGFP-----ECRN 683 Query: 633 TINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA-MDSYLIDPKRKLHVCGNNPTCDG 691 L+ + V CP+CG + R + C P C+ Sbjct: 684 ARPLLQKIGVT------------------CPQCGEGDIVQRRTKKGRVFYGCSRYPDCNF 725 Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKN 738 E+ C +CG + G + C+ + C+ Sbjct: 726 SSWEK---------PTGEPCPQCGGVLVETR---GGTVRCSTQGCQY 760 Score = 88.2 bits (217), Expect = 1e-15, Method: Composition-based stats. Identities = 30/102 (29%), Positives = 45/102 (44%), Gaps = 17/102 (16%) Query: 692 YEIEEGEFRIKGYDGPIVE-CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVA 749 E+ R+K D P E CEKCG M +K+GR+G+++AC+ EC+N R +L+ V Sbjct: 635 ERAEKEIGRVKVADEPTDEVCEKCGRPMVIKLGRYGRFLACSGFPECRNARPLLQKIGVT 694 Query: 750 PPKEDPVPLPELPCEKSD-AYFVLRDGAAGV-FLAANTFPKS 789 C + V R G F + +P Sbjct: 695 -------------CPQCGEGDIVQRRTKKGRVFYGCSRYPDC 723 Score = 64.3 bits (155), Expect = 2e-08, Method: Composition-based stats. Identities = 15/42 (35%), Positives = 24/42 (57%), Gaps = 1/42 (2%) Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 + CEK V++ G G FLA + FP+ R R PL++++ Sbjct: 651 TDEVCEKCGRPMVIKLGRYGRFLACSGFPECRNAR-PLLQKI 691 >UniRef50_C6HWV0 DNA topoisomerase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HWV0_9BACT Length = 865 Score = 700 bits (1807), Expect = 0.0, Method: Composition-based stats. Identities = 292/826 (35%), Positives = 417/826 (50%), Gaps = 92/826 (11%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G L++VESP KA+T+ + LG DY VK+SVGH++DLP S Sbjct: 47 GGTLIVVESPTKARTLTRILGPDYRVKASVGHLKDLPAS--------------------- 85 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 R+GVD ++E +EV GK+KV+ E++Q A A IYLA+D DREGEAIA+ Sbjct: 86 --------RIGVDVDRDYELEFEVSEGKKKVLDEIRQAARGAREIYLASDPDREGEAIAY 137 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ + RV+ +E+T I QA PGE+++ +V+AQ+ARR +DR+VGY +SP Sbjct: 138 HIASELSSLKKPIRRVLVHELTPRGIAQALEHPGEIDLHKVDAQKARRALDRIVGYSLSP 197 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST----TTPSGEALALQ 237 LLW+++ RGLSAGRVQSVAVRLV +RE EI AFVP E+W + + + +A + Sbjct: 198 LLWERVRRGLSAGRVQSVAVRLVCDRENEINAFVPVEYWTILQTFHPTESGRETDAFEAK 257 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + ++++ QA + L + + +P P TS LQQ + R Sbjct: 258 LDRIAGEKAEIGSQQEAQAVLERLSGENFRIGSVSADEKKRQPSPPLTTSRLQQEGARRF 317 Query: 298 GFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 F KKTM +AQ+LYE G ITYMRTDS L+ +A M R YI N+ + L Sbjct: 318 RFPAKKTMQVAQKLYEGVEIPGQGLTGLITYMRTDSVRLAPEAQEMARDYIRRNYPQG-L 376 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 P Y +K+ Q+AHEAIRP+DVN ESL ++ D ++YQLIW+ FV QM PA+ Sbjct: 377 PSKSPSYRNKKGIQDAHEAIRPTDVNRTPESLASVLDRDLLRVYQLIWQSFVESQMLPAR 436 Query: 408 YDSTTLTVGAGD-FRLKARGRILRFDGWTKVMPALRKG---------------DEDRILP 451 Y TT+ V +A GR + G+ V A KG +E+ LP Sbjct: 437 YLQTTVIVEGDQADSFRATGRRMLDPGFLAVRGARGKGAARSAKNEEEEDGTDEEEAELP 496 Query: 452 AVNKGDA-LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 +++G++ + L +QHFT+PP R++EASL++ELE++GIGRPSTYA+I++TI DR YV Sbjct: 497 LLHEGESVVALGPPDASQHFTQPPPRYNEASLIRELEEKGIGRPSTYATIMTTILDREYV 556 Query: 511 RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 RFY ++G+ V L ++F +L+N FTA+ME LD V + ++ +D F+ Sbjct: 557 EKRENRFYPTELGQTVNRLLVDSFPDLLNVAFTARMEEELDAVEEGDKVYREAVDDFYRP 616 Query: 571 FTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERC 630 F+ +L +A+ ++ T I CP CG M + G +L C Y C Sbjct: 617 FSAELGRAKGGGMTNLKAKSEP--TDIPCPVCGTLMVKKWGRHGAYLACGNYPA-----C 669 Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCD 690 KTT N+V G E C CG M C + P C Sbjct: 670 KTTRNIVQTES------GPAPEVLPEAPGEVCQTCGKPMIVR-KGRFGTFLACSDYPACK 722 Query: 691 GY---EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNG 746 + + C CG M +K GRFG +++C N CK TR + Sbjct: 723 TTRPWPPKGQPSPPVPLPADLPPCPACGGAMVVKSGRFGSFLSCANYPACKTTRPLPTGI 782 Query: 747 EVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRET 792 P D V R G GVF + +P+ T Sbjct: 783 RCTRPG-------------CDGEIVPRRGKRGVFYGCSRYPECDRT 815 Score = 99.0 bits (245), Expect = 7e-19, Method: Composition-based stats. Identities = 31/90 (34%), Positives = 43/90 (47%), Gaps = 2/90 (2%) Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPC 763 + + C CG+ M K GR G Y+AC N CK TR I++ E P E P C Sbjct: 637 EPTDIPCPVCGTLMVKKWGRHGAYLACGNYPACKTTRNIVQT-ESGPAPEVLPEAPGEVC 695 Query: 764 EKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 + ++R G G FLA + +P + TR Sbjct: 696 QTCGKPMIVRKGRFGTFLACSDYPACKTTR 725 Score = 60.5 bits (145), Expect = 3e-07, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 27/66 (40%), Gaps = 1/66 (1%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRF 803 + G + K P ++PC V + G G +LA +P + TR + E Sbjct: 625 KGGGMTNLKAKSEP-TDIPCPVCGTLMVKKWGRHGAYLACGNYPACKTTRNIVQTESGPA 683 Query: 804 RDRLPE 809 + LPE Sbjct: 684 PEVLPE 689 Score = 56.6 bits (135), Expect = 4e-06, Method: Composition-based stats. Identities = 32/143 (22%), Positives = 40/143 (27%), Gaps = 27/143 (18%) Query: 582 PEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL----- 636 P+ P + CP CG M +++ G FL C+ Y CKTT L Sbjct: 729 PKGQPSPPVPLPADLPPCPACGGAMVVKSGRFGSFLSCANYPA-----CKTTRPLPTGIR 783 Query: 637 ----------VPENEVLNVLEGEDAETNALRAK------RRCPKCGTAMDSYLIDPKRKL 680 VP V G R R CP CG A + Sbjct: 784 CTRPGCDGEIVPRRGKRGVFYGCSRYPECDRTYPGRPVARPCPSCGHAFLMEKKTGGKLR 843 Query: 681 HVCGNNPTCDGYEIEEGEFRIKG 703 VC C E + Sbjct: 844 LVCPEK-DCGYEAPEGEDPGTSP 865 >UniRef50_A8ZW15 DNA topoisomerase n=3 Tax=Desulfobacteraceae RepID=A8ZW15_DESOH Length = 758 Score = 700 bits (1806), Expect = 0.0, Method: Composition-based stats. Identities = 289/805 (35%), Positives = 421/805 (52%), Gaps = 78/805 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K ++IVESP K KTI KY G+ Y V ++ GH+RDLP Sbjct: 1 MNKPVIIVESPTKVKTITKYTGNAYSVTATSGHLRDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + +G+D + + Y + GK+KV+ LK AD IYLA D DREGEAIA Sbjct: 39 -------PHELGIDIDNGFAPDYVNIKGKQKVIKALKSAVGDADDIYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ +++ R+ RV+F+E+TK I++ +P ELN +R +AQQARR +DR+VGY +S Sbjct: 92 FHVADLLKKKGRRFHRVMFHELTKTGIQKGLTEPTELNRNRYDAQQARRILDRLVGYQIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLW+K+ GLSAGRVQSVAVR++ +REREI AF P+E+W + A+ + ++ Sbjct: 152 PLLWRKVRNGLSAGRVQSVAVRIICDREREIFAFDPQEYWSITAALEGANPPRFEAKLVK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + K N+ + V L + ++V + K P PF TS LQQ A +LGF Sbjct: 212 KGTKNITIGNQAEADRIVDELSRQAFTVDKIVQKTIKRNPQPPFTTSKLQQEAIRKLGFT 271 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 KKTM +AQ LYE G ITYMRTDST ++ +A + +I FG Y P+ Sbjct: 272 AKKTMAVAQELYEGIDLGPGEPVGLITYMRTDSTRIAPEAAHEALAHIRSVFGNDYAPDR 331 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 P +A+K Q+AHEAIRP+ ++ ES+K + D LY LIW++FVA QM+ A+ D Sbjct: 332 PRFFANKNKVQDAHEAIRPTGISYTPESVKRYLSKDQLTLYTLIWKRFVASQMSEAQIDQ 391 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALR------KGDEDRILPAVNKGDALTLVEL 464 T+T+ AGD+ L G +RF G+ + D+ LP +++ + L L+EL Sbjct: 392 KTITIAAGDYLLSVSGSTVRFPGFMALYQPEEDKNGAPDKDKGDKLPQLDEKEVLKLIEL 451 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 P QHFT PP RFSEASLVKELE+ GIGRPSTYA+I+STI+D+GYV + N+ F ++G Sbjct: 452 DPKQHFTTPPPRFSEASLVKELEENGIGRPSTYATILSTIRDKGYVDLINKAFRPTELGF 511 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 IV D L ENF +++ +FTA MEN LD++ + + + +L+ F+ F+Q+++ A+ Sbjct: 512 IVNDLLVENFPTILDIEFTANMENDLDRIESDQLQAVRLLERFYGPFSQRIEAAKDRMRS 571 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 + T + CP CG+++ I+ G FL CSGY CK + N ++ Sbjct: 572 VK---GVGMDTGLSCPECGKELKIKLGKNGPFLACSGYP-----DCKFSRNYARTDKGTV 623 Query: 645 VLEGEDAETNALRAKRR-CPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKG 703 E E + A+ + C KCG+ M C P C + Sbjct: 624 ----EPVEPDLTVAEGKSCEKCGSPMVVKQ-GRYGDFLACSAYPDCKSTQSLNSGANAAP 678 Query: 704 YDGPIVECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPEL 761 E C ++ K + GK + C+ +C + PV ++ Sbjct: 679 IGVKCPE-PGCNGDIVEKKSKRGKVFYGCSRFPKCTFASW-----------DKPV---DM 723 Query: 762 PCEKSDAYFVLRDG--AAGVFLAAN 784 C A FV+ G L Sbjct: 724 ACPDCGAPFVVEKTTKKEGTVLTCA 748 Score = 104 bits (258), Expect = 2e-20, Method: Composition-based stats. Identities = 27/87 (31%), Positives = 46/87 (52%), Gaps = 3/87 (3%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKI--LRNGEVAPPKEDPVPLPELPCEKSD 767 C +CG E+ +K+G+ G ++AC+ +CK +R G V P + D CEK Sbjct: 583 CPECGKELKIKLGKNGPFLACSGYPDCKFSRNYARTDKGTVEPVEPDLTVAEGKSCEKCG 642 Query: 768 AYFVLRDGAAGVFLAANTFPKSRETRA 794 + V++ G G FLA + +P + T++ Sbjct: 643 SPMVVKQGRYGDFLACSAYPDCKSTQS 669 Score = 55.1 bits (131), Expect = 1e-05, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 16/35 (45%) Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 L C + ++ G G FLA + +P + +R Sbjct: 579 TGLSCPECGKELKIKLGKNGPFLACSGYPDCKFSR 613 >UniRef50_D0LR99 DNA topoisomerase n=169 Tax=cellular organisms RepID=D0LR99_HALO1 Length = 894 Score = 699 bits (1805), Expect = 0.0, Method: Composition-based stats. Identities = 310/809 (38%), Positives = 426/809 (52%), Gaps = 92/809 (11%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GKALV+VESPAKA+TI KYLG DY VK+SVGHI+DLP Sbjct: 136 GKALVVVESPAKARTIGKYLGPDYTVKASVGHIKDLPK---------------------- 173 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 N++GVD +E Y V+ K+KV+SE+++ AE+ + +YLA D DREGEAIAW Sbjct: 174 -------NKIGVDVDQAFEPEYVVISDKKKVISEIRKAAERVEEVYLAPDPDREGEAIAW 226 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ E I + R++ NEITK + A P L+ ++ +AQQARR +DR+VGY +SP Sbjct: 227 HIAEEIKPINDNIKRILINEITKKGVNHAIANPTVLDTNKTDAQQARRILDRLVGYEISP 286 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 +LWKK+ RGLSAGRVQSVAVRL+VER++EI AF PEE+W VD + P A ++ Sbjct: 287 ILWKKVRRGLSAGRVQSVAVRLLVERDKEIAAFTPEEYWSVDVDCSAPEPPPFAAKIHRW 346 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + P + Q L +V + E K +P PFITS LQQ AS +L F Sbjct: 347 DGAKAEPKTEAQATEIADELRAQAAAVAKVERKERRRRPQPPFITSKLQQEASRKLRFSA 406 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 K+TM +AQRLYE G ITYMRTDST +S DA+ +R +I +G ++LP P Sbjct: 407 KRTMALAQRLYEGIELGSEGPLGLITYMRTDSTRISDDALAALRTHIQGTYGPEFLPAKP 466 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ------KLYQLIWRQFVACQMTPA 406 + Y S + +Q+AHEAIRP+ + E + A + KLY LIW++FVA QM PA Sbjct: 467 HTYKSPKRAQDAHEAIRPTTLEYPPERVAKALAGHREGKELVKLYTLIWQRFVASQMAPA 526 Query: 407 KYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE--------DRILPAVNKGDA 458 YD T + + G L+A G++++F G+ V A DE D++LP + +G A Sbjct: 527 VYDQTAVDIQCGRAILRASGQVMKFPGFLSVYRAQETDDEKAETAADQDKLLPHLEEGMA 586 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFY 518 + + P QHFT+PP RF+EASLVKELE+RGIGRPSTYASIISTI DRGYV RF+ Sbjct: 587 IHFDAIRPEQHFTQPPPRFTEASLVKELEERGIGRPSTYASIISTITDRGYVERREARFF 646 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 ++G IV D L E+F ++M+ DFTA ME LD+V E +W+ +L F+ F ++ A Sbjct: 647 PTELGAIVNDLLVESFPKIMDVDFTAAMEADLDKVEEGERDWRELLGGFYEPFRGNIEHA 706 Query: 579 EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVP 638 +++ + + + T C CG M I+ G FL C Y C+ T Sbjct: 707 KENMRDVK---REEIPTDHVCEKCGAPMVIKWGRNGSFLACQAYP-----DCRNT----- 753 Query: 639 ENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGE 698 E+ +G C +CG M C P C + Sbjct: 754 -KEINRNPDGSFEIVPEQTTDETCSECGAPMVVKRGRFG-AFLACSTYPECKNTQP---- 807 Query: 699 FRIKGYDGPIVECEK--CGSEMHLKMGRFGK-YMACTNEECKNTRKILRNGEVAPPKEDP 755 V+C K CG + K R GK + C+N + G + P Sbjct: 808 ------ISLGVDCPKDGCGGFLTEKRSRRGKPFYGCSNYS--------KTGCDFVTWDRP 853 Query: 756 VPLPELPCEKSDAYF-VLRDGAAGVFLAA 783 + C +A F V ++ G + Sbjct: 854 IA---EACPVCEASFLVKKETRRGTTVRC 879 Score = 104 bits (258), Expect = 2e-20, Method: Composition-based stats. Identities = 30/89 (33%), Positives = 49/89 (55%), Gaps = 2/89 (2%) Query: 706 GPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCE 764 CEKCG+ M +K GR G ++AC +C+NT++I RN + + P + C Sbjct: 719 PTDHVCEKCGAPMVIKWGRNGSFLACQAYPDCRNTKEINRNPDGSFEIV-PEQTTDETCS 777 Query: 765 KSDAYFVLRDGAAGVFLAANTFPKSRETR 793 + A V++ G G FLA +T+P+ + T+ Sbjct: 778 ECGAPMVVKRGRFGAFLACSTYPECKNTQ 806 Score = 62.4 bits (150), Expect = 8e-08, Method: Composition-based stats. Identities = 19/60 (31%), Positives = 24/60 (40%), Gaps = 4/60 (6%) Query: 741 KILRNGEVAPPKEDPVPLPELP----CEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPL 796 N E A V E+P CEK A V++ G G FLA +P R T+ Sbjct: 698 PFRGNIEHAKENMRDVKREEIPTDHVCEKCGAPMVIKWGRNGSFLACQAYPDCRNTKEIN 757 >UniRef50_D1BMP2 DNA topoisomerase n=6 Tax=Firmicutes RepID=D1BMP2_VEIPT Length = 791 Score = 699 bits (1804), Expect = 0.0, Method: Composition-based stats. Identities = 292/769 (37%), Positives = 412/769 (53%), Gaps = 81/769 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK LVIVESPAK+KTI K+LG +YVVK+S+GH+RDLP S Sbjct: 72 GKVLVIVESPAKSKTIEKFLGPNYVVKASMGHLRDLPKS--------------------- 110 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++G+D H++ Y L ++KV+ EL A+++ + LATD DREGEAI+W Sbjct: 111 --------QIGIDIEHDFTPRYSNLVTRKKVIDELVSYADESSAVLLATDPDREGEAISW 162 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL ++ D R+ FNEITKNA+ +A + P ++++ V+AQQARR +DR+VGY +SP Sbjct: 163 HLAYILNVDPTSTCRITFNEITKNAVAEALDSPRTIDMNMVDAQQARRVLDRIVGYKLSP 222 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLWKK+ +GLSAGRVQSVAVRL+ EREREI+AFVP+E+W ++ + TP EA ++TH Sbjct: 223 LLWKKVCKGLSAGRVQSVAVRLICEREREIQAFVPQEYWTIEGNFETPKKEAFIAELTHI 282 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + + QA V + V E + + K PF TSTLQQ +L FG Sbjct: 283 KGEKIDITTESDAQAIVDAIGNEDAVVTNIEKRKRSRKAVPPFTTSTLQQDGVRKLNFGA 342 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 K+TMM+AQ LYE G ITYMRTDST +S++ M + +I N+G+ Y P P Sbjct: 343 KRTMMIAQHLYEGLEIGSYGHVGLITYMRTDSTRISKEMQAMAKDFILRNYGEDYYPSKP 402 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 N Y SK ++Q+AHEAIRP+ + + + ++ + D KLY LIW +F+A QM P + +ST Sbjct: 403 NVYGSKGSAQDAHEAIRPTSLELTPKMVEPFLSRDELKLYTLIWNRFMASQMAPQQNEST 462 Query: 412 TLTVGA-GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 T+ + D+ KA G + F G++ V +K D + LPA+ K A VE+ P QHF Sbjct: 463 TIELNVKNDYTFKATGSRVIFPGFSAVYEDAKKEDVPQ-LPALKKNYAAHTVEVLPEQHF 521 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP R+SEASL+K LE+ GIGRPSTYA I+ TI R YV N++F ++G +V D L Sbjct: 522 TQPPPRYSEASLIKTLEELGIGRPSTYAPILDTIVSRNYVENTNKQFVPTELGFVVVDFL 581 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 F +++N FT +E LD +A+ + + VL F+ F Q+L+ A + Sbjct: 582 ITYFEKIINTGFTRDLEEELDAIASGKDTYVKVLSDFYEVFAQELEDAS----DVDRIEI 637 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 + + C C M + G FL CS + CK T + Sbjct: 638 ASMESDEICELCNSPMVYKFGRYGKFLACSNFP-----ECKNTKPI-------------- 678 Query: 651 AETNALRAKRRCPKC-GTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV 709 + CPKC + R + C P CD +D P Sbjct: 679 ----TVGTGVTCPKCKEGEIVERKSRRGRIFYGCNRYPQCDFTL----------WDKPTH 724 Query: 710 E-CEKCGSEMHLKMGRFGKYMA-CTNEECKNTRKILRNGEVAPPKEDPV 756 + CE CGS M K + G C+NE C + + E+PV Sbjct: 725 DFCETCGSIMVEKTYKNGTVKKFCSNETCPTRPPKKTRKKKSEASEEPV 773 Score = 85.1 bits (209), Expect = 1e-14, Method: Composition-based stats. Identities = 28/85 (32%), Positives = 37/85 (43%), Gaps = 16/85 (18%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKS-DA 768 CE C S M K GR+GK++AC+N ECKNT+ I + C K + Sbjct: 646 CELCNSPMVYKFGRYGKFLACSNFPECKNTKPITVG-------------TGVTCPKCKEG 692 Query: 769 YFVLRDGAAGV-FLAANTFPKSRET 792 V R G F N +P+ T Sbjct: 693 EIVERKSRRGRIFYGCNRYPQCDFT 717 Score = 60.5 bits (145), Expect = 3e-07, Method: Composition-based stats. Identities = 12/39 (30%), Positives = 20/39 (51%) Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 + CE ++ V + G G FLA + FP+ + T+ V Sbjct: 642 SDEICELCNSPMVYKFGRYGKFLACSNFPECKNTKPITV 680 >UniRef50_Q67PC7 DNA topoisomerase n=3 Tax=Bacteria RepID=Q67PC7_SYMTH Length = 735 Score = 699 bits (1804), Expect = 0.0, Method: Composition-based stats. Identities = 294/797 (36%), Positives = 429/797 (53%), Gaps = 113/797 (14%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+L+IVESPAKAKTI K+LG Y VK+S+GH+RDLP S Sbjct: 1 MPKSLIIVESPAKAKTIEKFLGRKYAVKASMGHVRDLPKS-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++GV +++E Y + GK ++ EL++ A KAD +YLATD DREGEAI+ Sbjct: 41 ---------QLGVSVENDFEPKYITIRGKGDILKELRESARKADRVYLATDPDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +V+ R+ F+EITK+AI++A +P ++++RV AQQARR +DR+VGY +S Sbjct: 92 WHLAQVLKLPLDEPLRIEFHEITKDAIQRAIKQPRPIDLNRVEAQQARRVLDRLVGYKLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLW+K+ RGLSAGRVQSVAVRL+V+REREI+AF PEE+W +DA +T ++ + + Sbjct: 152 PLLWRKVRRGLSAGRVQSVAVRLIVDREREIQAFQPEEYWTLDARLSTAFAQSFSARYWG 211 Query: 241 QNDKPFRPVNKEQTQAAVSLL------------------------------EKARYSVLE 270 ++ ++Q +A V + E V Sbjct: 212 MGEQKADLKTQDQVRAVVHQVAGDRLPAGNAAVSGEGTPGDPFTEVLDLAGEGLVLQVRS 271 Query: 271 REDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMR 321 + + P PF TS+LQQ AS +LGF V++TM +AQ+LYE G +TY+R Sbjct: 272 VKRREKKRNPAYPFTTSSLQQEASRKLGFSVRRTMAVAQQLYEGLPLGEEGHTGLVTYIR 331 Query: 322 TDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK 381 TDST ++ +A +I +GK Y+PE + + Q AHEAIRP+DV ES+K Sbjct: 332 TDSTRIADEAARAAAEFIERQYGKDYVPERRREPDRRAGEQGAHEAIRPTDVTRTPESVK 391 Query: 382 D-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPA 440 + D +LY+LIW +F+A QM PA D+ T+ + AG+ +A G+ +RF G+ KV Sbjct: 392 PYLTPDQYRLYRLIWERFLASQMAPAVLDTVTVELVAGEHVFRASGQSIRFPGFMKVYIE 451 Query: 441 LRKGDE-----DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPS 495 D D +LP + +G +TL L QHFT+PP R+SEA LVK LE+RGIGRPS Sbjct: 452 GEDDDGQREEGDDLLPELAEGQQVTLQTLEARQHFTQPPPRYSEAMLVKALEERGIGRPS 511 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 TYA II TIQ RGYV ++RFY ++G +VTD L+E F ++++ +FTA +E LD+V Sbjct: 512 TYAPIIGTIQTRGYVEKRDKRFYPTELGVLVTDILKEYFPDIIDVEFTAHLEGKLDEVEE 571 Query: 556 HEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV 615 W+ ++ F+ F + L +AE E+ G + ++ + C CGR M ++ G Sbjct: 572 GRVNWRELIRRFYGPFEETLKQAE---EKVGGFELEDEVSDVPCEKCGRLMVVKHGRFGK 628 Query: 616 FLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA--MDSYL 673 FL C G+ CK+T ++ E V CP CGT ++ Sbjct: 629 FLACPGFP-----ECKSTKPILEETGVT------------------CPACGTGRIVERKS 665 Query: 674 IDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL--KMGRFGKYMAC 731 R+ + C N P C+ E+ R+ C +CG+ + ++ G C Sbjct: 666 KKGGRRFYGCTNYPDCNFVSWEKPVNRL---------CPECGAPYLVEKRIKELGLSHVC 716 Query: 732 TNEECKNTRKILRNGEV 748 +C + EV Sbjct: 717 KQPDCGYVEPVESMEEV 733 Score = 82.4 bits (202), Expect = 7e-14, Method: Composition-based stats. Identities = 27/89 (30%), Positives = 35/89 (39%), Gaps = 17/89 (19%) Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPC 763 + V CEKCG M +K GRFGK++AC ECK+T+ IL + C Sbjct: 606 EVSDVPCEKCGRLMVVKHGRFGKFLACPGFPECKSTKPILEE-------------TGVTC 652 Query: 764 EKSD-AYFVLRDGAAG--VFLAANTFPKS 789 V R G F +P Sbjct: 653 PACGTGRIVERKSKKGGRRFYGCTNYPDC 681 Score = 65.1 bits (157), Expect = 1e-08, Method: Composition-based stats. Identities = 18/62 (29%), Positives = 30/62 (48%), Gaps = 1/62 (1%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 + + E E + ++PCEK V++ G G FLA FP+ + T+ P++ Sbjct: 587 FEETLKQAEEKVGGFELEDEVSDVPCEKCGRLMVVKHGRFGKFLACPGFPECKSTK-PIL 645 Query: 798 EE 799 EE Sbjct: 646 EE 647 >UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_AMMDK Length = 686 Score = 696 bits (1797), Expect = 0.0, Method: Composition-based stats. Identities = 279/749 (37%), Positives = 401/749 (53%), Gaps = 78/749 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+IVESPAKA+T++K+LGS ++VK+S+GH+RDLP S Sbjct: 2 KHLIIVESPAKARTLSKFLGSQFLVKASMGHVRDLPKS---------------------- 39 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +GVD + + Y + GK KV+ ELK KAD + +A+D DREGEAIAWH Sbjct: 40 -------ELGVDLENGFTPKYVTIRGKGKVIQELKSYVAKADTVLMASDPDREGEAIAWH 92 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L ++G RV F+EITKNA+ + P ++++RVNAQQARR +DR+VGY +SPL Sbjct: 93 LCHLLGIPPETPCRVEFHEITKNAVLNSLKSPRPIDLNRVNAQQARRVLDRLVGYGLSPL 152 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LW+K+ RGLSAGRVQSVA+RLVVERE EI+AF PEE+W++ TP E + ++ Sbjct: 153 LWRKVKRGLSAGRVQSVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLARLARFK 212 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K F E+ + S A + V + + P PF TS + Q A+ RLG ++ Sbjct: 213 GKKFTCRTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQEANRRLGMRLE 272 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE-SP 352 +TM +AQ+LYE G ITY+RTDST +S++A +I +++G +++ + P Sbjct: 273 RTMAVAQQLYEGVDLGPEGPVGLITYIRTDSTRVSEEAKERAWAFIKEHYGAEFVGDVPP 332 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 + +K ++AHEAIRP+DV E +K + D KLY+LIW +F+A M PAKY T Sbjct: 333 KERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLIWERFLAAHMAPAKYFLT 392 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + GD+ A GR L F G+ ++ + +E + LP + +G+ LT E P QHFT Sbjct: 393 RAEIEVGDYTFYATGRQLLFPGFLRLWRPEEEEEEGK-LPPLREGEVLTFQEFVPQQHFT 451 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 PP R++E +LVK LE++G+GRPSTYA I TI RGYV ++ + +G V + L+ Sbjct: 452 TPPPRYTEGTLVKALEEKGVGRPSTYAPTIETILKRGYVVRVDKYLHPTPLGRTVVELLK 511 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 E+F +++ FTA ME LD V +A+W +L F+ F+Q L +A+ E+ + Sbjct: 512 EHFPGIVDVGFTAAMEEKLDLVEEGQADWVDILREFYQSFSQDLVRADAAIEKVSL---P 568 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 T I CP CG M +T G FL CSGY E Sbjct: 569 DTFTDISCPRCGCPMVKKTGRYGEFLACSGYP-------------------------ECQ 603 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVEC 711 + +CP+CG + R + C P C+ + + C Sbjct: 604 MRMPVGTGVKCPRCGGELVKRRSKKGRYFYGCNRYPECNF---------VVWSEPVPEPC 654 Query: 712 EKCGSEMHLKMGRFGKYMACTNEECKNTR 740 +CGS M + K + CTNE C R Sbjct: 655 PECGSLMVRRGRGKKKRVICTNESCGYQR 683 Score = 82.1 bits (201), Expect = 8e-14, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 32/85 (37%), Gaps = 17/85 (20%) Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 + C +CG M K GR+G+++AC+ EC+ + + C + Sbjct: 572 TDISCPRCGCPMVKKTGRYGEFLACSGYPECQMRMPV---------------GTGVKCPR 616 Query: 766 SDAYFVLRDGAAGV-FLAANTFPKS 789 V R G F N +P+ Sbjct: 617 CGGELVKRRSKKGRYFYGCNRYPEC 641 Score = 78.2 bits (191), Expect = 1e-12, Method: Composition-based stats. Identities = 26/139 (18%), Positives = 42/139 (30%), Gaps = 27/139 (19%) Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 E CP+CG M + C P C +++ G Sbjct: 563 EKVSLPDTFTDISCPRCGCPMVK-KTGRYGEFLACSGYPEC----------QMRMPVGTG 611 Query: 709 VECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKS 766 V+C +CG E+ + + G+ + C EC +PVP PC + Sbjct: 612 VKCPRCGGELVKRRSKKGRYFYGCNRYPECNFVVW-----------SEPVP---EPCPEC 657 Query: 767 DAYFVLRDGAAGVFLAANT 785 + V R + Sbjct: 658 GSLMVRRGRGKKKRVICTN 676 Score = 61.3 bits (147), Expect = 2e-07, Method: Composition-based stats. Identities = 10/53 (18%), Positives = 22/53 (41%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSR 790 ++ ++R P ++ C + V + G G FLA + +P+ + Sbjct: 551 FSQDLVRADAAIEKVSLPDTFTDISCPRCGCPMVKKTGRYGEFLACSGYPECQ 603 >UniRef50_Q9KA23 DNA topoisomerase 1 n=107 Tax=Bacteria RepID=TOP1_BACHD Length = 690 Score = 691 bits (1783), Expect = 0.0, Method: Composition-based stats. Identities = 291/756 (38%), Positives = 411/756 (54%), Gaps = 83/756 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG Y VK+S+GH+RDLP S Sbjct: 1 MADYLVIVESPAKAKTIGKYLGKKYTVKASMGHVRDLPKS-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +MGVD + Y + GK V+ ELK A+K +YLA D DREGEAIA Sbjct: 41 ---------QMGVDIEDEYSPRYITIRGKGPVLKELKSAAKKVKRVYLAADPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL + D+ RVVFNEITK AI+ AF P +N+D V+AQQARR +DR+VGY +S Sbjct: 92 WHLAHSLDIDETSECRVVFNEITKQAIKDAFKSPRPINMDLVDAQQARRVLDRLVGYNIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWKK+ +GLSAGRVQSVAV+++++RE+EI+AF PEE+W + + GE + Sbjct: 152 PLLWKKVKKGLSAGRVQSVAVKMIIDREKEIQAFEPEEYWSIQGTFALD-GEPFEAKFYG 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 N K +++ ++ L+ ++ V + K P +PF TS+LQQ A+ +L F Sbjct: 211 TNGKKVELKSEDDVNNVLAKLKGDQFHVDSVQKKERKRNPVSPFTTSSLQQEAARKLNFR 270 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 KKTMM+AQ+LYE G ITYMRTDST +S A + YI FGK+Y Sbjct: 271 AKKTMMLAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKAETKEYIESKFGKEYAQNG 330 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 + SQ+AHEAIRP+ V +SLK+ + D +LY+LIW + VA QM PA D+ Sbjct: 331 TKAVKKDKKSQDAHEAIRPTSVERDPKSLKEYLSRDQLRLYKLIWERLVASQMAPAIMDT 390 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGDALTLVELTPA 467 T+ + +A G ++F G+ KV K +EDR+LP + +G +T E+ P+ Sbjct: 391 MTVDLSNEGVLFRATGSKVKFPGFMKVYIEGNDEGKKEEDRLLPNLQEGQTVTKEEIEPS 450 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFT+PP R++EA LVK +E+ GIGRPSTYA + TIQ RGYV ++ RRF ++GEIV Sbjct: 451 QHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQKRGYVALDERRFVPTELGEIVL 510 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 + + E F E+++ +FTA+ME+ LD + + +W ++D F+ F ++L AE++ +E + Sbjct: 511 ELMTEFFPEILDVEFTAKMEDDLDSIEEGKQQWIKIIDDFYKGFEERLKVAEEEMKEVEI 570 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 + T C CG +M + G F+ CS + C+ T +V E V Sbjct: 571 KDE---PTGEMCEKCGHEMVYKMGRYGKFMACSNFP-----DCRNTKPIVKEIGV----- 617 Query: 648 GEDAETNALRAKRRCPKCGT-AMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDG 706 +CPKC + +R + C P CD +D Sbjct: 618 -------------KCPKCEKGEIVERKSKKRRVFYGCNQYPECDF----------VSWDK 654 Query: 707 PIVE-CEKCGSEMHLKMGRFGKYMACTNEECKNTRK 741 PI C KC S + K + + C++ C + Sbjct: 655 PIARSCPKCSSYLVEKRTKKQVQVQCSS--CDYKEE 688 Score = 86.7 bits (213), Expect = 4e-15, Method: Composition-based stats. Identities = 38/99 (38%), Positives = 50/99 (50%), Gaps = 15/99 (15%) Query: 694 IEEGEFRIKGYDGPIVE-CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPP 751 EE ++ D P E CEKCG EM KMGR+GK+MAC+N +C+NT+ I++ V P Sbjct: 561 AEEEMKEVEIKDEPTGEMCEKCGHEMVYKMGRYGKFMACSNFPDCRNTKPIVKEIGVKCP 620 Query: 752 KEDPVPLPELPCEKSDAYFVLRDGA-AGVFLAANTFPKS 789 K CEK V R VF N +P+ Sbjct: 621 K----------CEK--GEIVERKSKKRRVFYGCNQYPEC 647 Score = 65.1 bits (157), Expect = 1e-08, Method: Composition-based stats. Identities = 67/455 (14%), Positives = 135/455 (29%), Gaps = 81/455 (17%) Query: 403 MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLV 462 P +Y S T +A+ + K + + D + +L + KGD + Sbjct: 185 FEPEEYWSIQGTFALDGEPFEAKF----YGTNGKKVELKSEDDVNNVLAKL-KGDQFHVD 239 Query: 463 ELTPAQHFTKPPARFSEASL-------------------------VKELEKRGIG----- 492 + + P + F+ +SL + ++ +G Sbjct: 240 SVQKKERKRNPVSPFTTSSLQQEAARKLNFRAKKTMMLAQQLYEGIDLGKEGTVGLITYM 299 Query: 493 -RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT-DRLEENFRELMNYDFTAQMENSL 550 ST S + + + Y+ + + YA+ + V D+ ++ E + Sbjct: 300 RTDSTRISDTAKAETKEYIESKFGKEYAQNGTKAVKKDKKSQDAHEAIRPT--------- 350 Query: 551 DQVANHEAEWKAVLDH----FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKM 606 V K L + ++L ++ P + + G K+ Sbjct: 351 -SVERDPKSLKEYLSRDQLRLYKLIWERLVASQMAPAIMDTMTVDLSNEGVLFRATGSKV 409 Query: 607 GIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 F+ Y E K L+P + + E+ E + + P+ Sbjct: 410 -----KFPGFM--KVYIEGNDEGKKEEDRLLPNLQEGQTVTKEEIEPSQHFTQPP-PRYT 461 Query: 667 TAMDSYLIDPKRKLHVCGNNPTCDG----------------YEIEEGEFRIKGYDGPIVE 710 A ++ PT D E+ E + P + Sbjct: 462 EARLVKTMEELGIGRPSTYAPTLDTIQKRGYVALDERRFVPTELGEIVLELMTEFFPEIL 521 Query: 711 CEKCGSEMH-----LKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 + ++M ++ G+ + ++ E E CEK Sbjct: 522 DVEFTAKMEDDLDSIEEGKQQWIKIIDDFYKGFEERLKVAEEEMKEVEIKDEPTGEMCEK 581 Query: 766 SDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 V + G G F+A + FP R T+ P+V+E+ Sbjct: 582 CGHEMVYKMGRYGKFMACSNFPDCRNTK-PIVKEI 615 >UniRef50_B1GYR4 DNA topoisomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYR4_UNCTG Length = 740 Score = 691 bits (1782), Expect = 0.0, Method: Composition-based stats. Identities = 307/785 (39%), Positives = 435/785 (55%), Gaps = 66/785 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP K KTI+K LG D+ VKSS GHIRDLP Sbjct: 1 MSKYLVIVESPTKEKTISKILGKDFTVKSSYGHIRDLPK--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 N++G+D N++ Y+ + +K++S+LK+ AE +D IYLATD DREGEAIA Sbjct: 40 --------NKLGIDIEDNFKPTYKNISKSKKLISDLKKKAENSDKIYLATDFDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+E + +++ SR+ F+EIT AI +A P L++ VN+QQARR +DR+VGY +S Sbjct: 92 WHLKEALKLPESKISRITFHEITTEAILKAVKHPRNLDMKLVNSQQARRILDRLVGYKLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS-----GEALA 235 PLLWKK+ GLSAGRVQSVAV L+ +RE E K+F+P E+W ++A + ++L Sbjct: 152 PLLWKKVKPGLSAGRVQSVAVMLICKREEEFKSFIPVEYWSIEAELSKLEENTTPFKSLL 211 Query: 236 LQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 NKEQ+ + LE A+Y V E K P AP+ TST+QQ AS Sbjct: 212 FSKNDVKFDKLSVKNKEQSDETLKELEGAKYIVKSVETKQRKRSPYAPYTTSTMQQDASR 271 Query: 296 RLGFGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 +LGF KTM AQ+LYE AG ITYMRTDS N+++ + +I ++G Sbjct: 272 KLGFSASKTMSAAQKLYEGVHIGNSTNAGLITYMRTDSLNIAKSVQSETLKFIEYSYGSN 331 Query: 347 YLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMT 404 +LP+ P Y +K + +QEAHEAIRP N + +K + D KLY LIW++F+A QM Sbjct: 332 FLPKIPRIYKTKTKGAQEAHEAIRPISPNRIPSEVKQYLSEDELKLYNLIWKRFLASQMA 391 Query: 405 PAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 464 A Y++ T + A D+ K+ L FDG+ KV A E + LP++ G+ L L+ L Sbjct: 392 DAVYNTVTAEILAKDYLFKSLESTLIFDGFLKVYNADDDEKETKKLPSLKSGEQLNLLRL 451 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 P QHFT+PP + ASL+K LE+ GIGRPSTYA I TI DR YV ++ ++F G Sbjct: 452 LPLQHFTEPPPLYDVASLIKALEEHGIGRPSTYAPTIKTILDRLYVHLDGKKFVPTNRGI 511 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 +V + L+++F ++N +FTA +E LD++A +A W+ VL F+ F + L +AEK+ ++ Sbjct: 512 VVNNVLKDHFGNIINVEFTASVEEKLDKIAEDKAVWQNVLKDFYKPFKKDLSEAEKNLQK 571 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 ++ Q TS CP CG+ M IR + FLGCSGY CKTT++L + ++ Sbjct: 572 QKVQAQQ---TSEICPNCGKNMVIRYSRKVQFLGCSGYP-----ECKTTLSLDKDGKIAA 623 Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 D +C KCG+ + ++ C N P C + Y Sbjct: 624 APRETD---------MKCDKCGSHLIKKTGFAGKQYLSCKNYPECKTLYNINKDGNKIIY 674 Query: 705 DGP---IVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPE 760 P ++C KCGSEM K+G+ G ++ C+ +C+N + I N V L E Sbjct: 675 PEPEHTDIKCNKCGSEMLKKIGKRGPFLTCSAFPKCRNLQWIKTNKTPKSKTYKTVKLSE 734 Query: 761 LPCEK 765 K Sbjct: 735 KKTTK 739 Score = 54.7 bits (130), Expect = 1e-05, Method: Composition-based stats. Identities = 7/57 (12%), Positives = 18/57 (31%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 + + + ++ C V+R FL + +P+ + T + Sbjct: 558 FKKDLSEAEKNLQKQKVQAQQTSEICPNCGKNMVIRYSRKVQFLGCSGYPECKTTLS 614 >UniRef50_Q2LT40 DNA topoisomerase n=2 Tax=Bacteria RepID=Q2LT40_SYNAS Length = 769 Score = 687 bits (1773), Expect = 0.0, Method: Composition-based stats. Identities = 303/827 (36%), Positives = 429/827 (51%), Gaps = 110/827 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M +L+IVESP K KT+ KYLG+DY V +S GHI+DLP Sbjct: 1 MPDSLIIVESPTKVKTLKKYLGADYEVLASKGHIKDLPK--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +G+DP + ++ Y V+ K+KV+++LK+ A+ I+LA D DREGEAIA Sbjct: 40 --------KTLGIDPQNEFQPTYSVIDDKKKVIADLKKAAKNVSRIFLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ E I + RV+FN++TKN I A N PG+L+ ++ AQQ RR +DR+VGY +S Sbjct: 92 WHIAEEIKAKNKEIYRVLFNDLTKNTILDAINHPGKLDFNKYEAQQTRRILDRLVGYQIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW+K+ RGLSAGRVQSVAVR++ +RE EIK F+PEE+W + + ++ Sbjct: 152 PILWEKVKRGLSAGRVQSVAVRMICDREEEIKRFIPEEYWNISVQLKGVTPPPFEARLIK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKA-------------------RYSVLEREDKPTTSKPG 281 K + N+ Q VS L ++ V + E K + Sbjct: 212 ITGKKAKVKNEAQANEIVSRLSGGVKSGSKPTINLSEDRDLQPQFVVSKLEKKEVKKESL 271 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAV 332 PF TS LQQ AS L F KKTM AQ+LYE G ITYMRTDS +++DA+ Sbjct: 272 PPFTTSKLQQEASRLLRFSAKKTMATAQKLYEGIELGEEGPVGLITYMRTDSVRIAEDAL 331 Query: 333 NMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLY 391 VR YI +N+ +LP + SK +Q+AHEAIRPS +N + +K + AD +LY Sbjct: 332 KEVRSYIRENYDPPFLPAKARFFKSKGKTQDAHEAIRPSSMNYNPQKIKHFLSADQFRLY 391 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED---- 447 QLIW +FVA QM PA YD TT+ V A + +A+G IL+F G+T V ++ E Sbjct: 392 QLIWNRFVASQMNPALYDQTTVEVSADFYTFRAQGAILKFPGYTIVYTEGKEDKEQNEEM 451 Query: 448 ---RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTI 504 +ILP +N+G+ LTL+++TP Q FT+PP RFSEASLV+ELE++GIGRPSTYA+I+STI Sbjct: 452 ESGKILPDLNEGERLTLLKITPEQKFTQPPPRFSEASLVRELEEQGIGRPSTYAAILSTI 511 Query: 505 QDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 QDR Y R+E +F+ ++G IVT+ L +NF ++M+ FTA +EN LD + + + L Sbjct: 512 QDRNYARLEQGKFHPTELGTIVTELLVKNFPKVMDVSFTASLENQLDLIEEGKQKRIETL 571 Query: 565 DHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYAL 624 F++ F + L KA + + + T + C C M I+ G F+ CS Y Sbjct: 572 QEFYAPFEEDLSKARLEMKNIK---REETPTDLICEKCQSPMVIKWGKNGKFIACSNYPA 628 Query: 625 PPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCG 684 CK T N+ V +G CPKCG M R C Sbjct: 629 -----CKNTRNIEQGEGVERSAKG------GEMTDTVCPKCGKNMLIKHGRFGR-FLGCS 676 Query: 685 NNPTCDGYEIEEGEFRIKGYDGPIVECEK--CGSEMHLKMGRFGK-YMACTN-EECKNTR 740 P C V+C + C E+ K + G+ + C+N C Sbjct: 677 GYPDCKHTMP----------ISLGVKCPQEGCDGEIIEKRTKKGRSFFGCSNYPNCTFAV 726 Query: 741 KILRNGEVAPPKEDPVPLPELPCEKSDAYF-VLRDGA-AGVFLAANT 785 + P+P PC + ++ F V + G + A Sbjct: 727 W-----------DKPIP---EPCPQCNSPFLVEKYSRTEGSYKACPN 759 Score = 107 bits (267), Expect = 2e-21, Method: Composition-based stats. Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 2/83 (2%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 CEKC S M +K G+ GK++AC+N CKNTR I GE + + C K Sbjct: 603 CEKCQSPMVIKWGKNGKFIACSNYPACKNTRNI-EQGEGVERSAKGGEMTDTVCPKCGKN 661 Query: 770 FVLRDGAAGVFLAANTFPKSRET 792 +++ G G FL + +P + T Sbjct: 662 MLIKHGRFGRFLGCSGYPDCKHT 684 Score = 59.3 bits (142), Expect = 6e-07, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 20/35 (57%) Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 +L CEK + V++ G G F+A + +P + TR Sbjct: 599 TDLICEKCQSPMVIKWGKNGKFIACSNYPACKNTR 633 >UniRef50_C0QYG0 DNA topoisomerase n=2 Tax=Brachyspira RepID=C0QYG0_BRAHW Length = 716 Score = 682 bits (1760), Expect = 0.0, Method: Composition-based stats. Identities = 289/757 (38%), Positives = 417/757 (55%), Gaps = 82/757 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKAKTIN+YLGSDY+V SS+GH+ DLP Sbjct: 28 LVIVESPAKAKTINRYLGSDYLVMSSMGHLIDLP-------------------------- 61 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +R+ +D H +E Y + G+ K+++ELK+ A+KA+ + LA D DREGE+IAWH+ Sbjct: 62 ---RSRLAIDVDHGFEPEYITIRGRAKILNELKKEAKKAEEVLLAADDDREGESIAWHIG 118 Query: 125 EVIGGDDA--RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 I G ++ R+VF+EITK+A+++A ++P +++I +VNAQ+ARR +DR++GY +SPL Sbjct: 119 NKIRGVNSAVPIKRIVFHEITKDALKEAIDQPRDIDISKVNAQKARRVLDRLIGYNLSPL 178 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LW KI RGLSAGRVQ+VA+ ++ RE EI+ FVP E+W + E LA ++ Sbjct: 179 LWDKIKRGLSAGRVQNVALLIICNREDEIETFVPVEYWTFGVFLKHKNKEFLAELQKYKG 238 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 +KP K+ + + L+ Y+V E K P AP+ TS LQQAAS+ LG+ Sbjct: 239 EKP-DLKTKQDVEDIMEHLKDKTYTVASIEVKDRLRNPTAPYTTSKLQQAASSALGYSAS 297 Query: 303 KTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 KTM +AQ LYE G ITYMRTDS +S A + +I +G YLP P Sbjct: 298 KTMQVAQSLYEGVDIAGEATGLITYMRTDSVRISPVAQEQAKEFIEKEYGSNYLPPEPPT 357 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 Y+ K+N+Q+AHEAIRP+++ + +S+K+ ++ D KLY+LIW +FV+ QM PAK +T Sbjct: 358 YSVKKNAQDAHEAIRPTNIFLTPDSIKEYLKTDQYKLYKLIWERFVSSQMLPAKMKNTRA 417 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDED-RILPAVNKGDALTLVELTPAQHFTK 472 + AGD + FDG+ KV+ ++ E +P ++K D VE P QHFT Sbjct: 418 IIVAGDCEFSLSSSKIEFDGFMKVLTIDKEDKEKASKMPNLSKDDVCEFVENNPQQHFTT 477 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PP R+++ASLVK LE+ GIGRPSTYA I TI R YV+ + ++ ++G++V + + E Sbjct: 478 PPPRYTDASLVKILEESGIGRPSTYAPTIKTIISRHYVQRKGKQLVPTELGKLVNELISE 537 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 NF EL+N +FTA ME+ LD++ + EW +L F+ F L A ++ M+ Sbjct: 538 NFPELVNINFTADMESKLDKIEDDNIEWNNILKEFYPHFLDTLKTATENI--NNMKDFFN 595 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 T C CG+KM R G F+ CSG+ CK T + Sbjct: 596 EETDFVCEKCGKKMIKRLGRYGYFIACSGFP-----ECKNTKGI---------------- 634 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE-C 711 + CPKCG + R+ + C N P CD +D P+ E C Sbjct: 635 -----SFGVCPKCGGDITLKRSKRGREFYGCSNYPKCDF----------VSWDKPLQEPC 679 Query: 712 EKCGSEMHLKMGR-FGKYMACTNEECKNTRKILRNGE 747 KCG M K + G + C E+C + +I + E Sbjct: 680 PKCGGLMVEKNIKNKGLFKVCIKEDCGYSEEIKEDEE 716 Score = 79.8 bits (195), Expect = 5e-13, Method: Composition-based stats. Identities = 24/81 (29%), Positives = 35/81 (43%), Gaps = 18/81 (22%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 CEKCG +M ++GR+G ++AC+ ECKNT+ I C K Sbjct: 602 CEKCGKKMIKRLGRYGYFIACSGFPECKNTKGISFG----------------VCPKCGGD 645 Query: 770 FVLRDGAAG-VFLAANTFPKS 789 L+ G F + +PK Sbjct: 646 ITLKRSKRGREFYGCSNYPKC 666 Score = 59.7 bits (143), Expect = 4e-07, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 18/37 (48%) Query: 757 PLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 + CEK + R G G F+A + FP+ + T+ Sbjct: 596 EETDFVCEKCGKKMIKRLGRYGYFIACSGFPECKNTK 632 >UniRef50_A9FRC6 DNA topoisomerase I n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FRC6_SORC5 Length = 864 Score = 681 bits (1758), Expect = 0.0, Method: Composition-based stats. Identities = 310/854 (36%), Positives = 426/854 (49%), Gaps = 140/854 (16%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI KYLG+ Y V +S GH++DLP +A Sbjct: 1 MAKTLVIVESPAKAKTIKKYLGNGYEVFASKGHVKDLPKKQNA----------------- 43 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VD +++ YEV+ GKEKV+ ELK A+KAD + LATD DREGEAIA Sbjct: 44 ------------VDVQNDFAETYEVIEGKEKVLEELKSAAKKADEVLLATDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ E I + +RV F+EITK + + P +L+ + +AQ+ARR +DR+VGY VS Sbjct: 92 FHISEEIKNPKLKVARVEFHEITKKGVDHGVHNPRKLDENLYDAQRARRVLDRIVGYDVS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST---TTPSGEALALQ 237 L+W K+A GLSAGRVQSVA+RL+V+RERE++AFVPEE+W + + P + Sbjct: 152 ALVWSKLAFGLSAGRVQSVALRLIVDREREVEAFVPEEYWNIAVGLGAASPPQRAPFVAK 211 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + K N E + LE ARY V + + P AP+ TS LQQ A+ L Sbjct: 212 LASADGKKLEVTNGEVAGKVRADLETARYRVAKVVRREQKRNPPAPYTTSKLQQDATNYL 271 Query: 298 GFGVKKTMMMAQRLYEA----------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 FG K+TM +AQ LYE G ITYMRTDST +S DAV VRG ++ +GK++ Sbjct: 272 HFGAKRTMQIAQALYEGIDLKRDGGPVGLITYMRTDSTRVSDDAVAEVRGVVAKRYGKEF 331 Query: 348 LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPA 406 +PE PN + SK+N+Q+AHEAIRP+ V + +S+K ++ + KLY+LIW +FVA QMTPA Sbjct: 332 VPERPNVFKSKKNAQDAHEAIRPTSVEIHPDSIKKHLKDEQYKLYKLIWNRFVASQMTPA 391 Query: 407 KYDSTTLTVGAGD---------FRLKARGRILRFDGWTKVMPALR--------------- 442 YD TT+ + + +A GRIL+F GW +V + Sbjct: 392 VYDRTTVEIDVAPTLAAPAYRSYLARATGRILKFAGWLQVTEGQQEFAGEEESAGAAADG 451 Query: 443 -----------------------KGDEDRILPAVNKGDALTLV--ELTPAQHFTKPPARF 477 + D + +LP + +G+AL++ + Q FT+PP R+ Sbjct: 452 GAAAPAPEATAAEAERAAPGPSAEEDSEALLPDMKEGEALSVSPPGVITDQKFTQPPPRY 511 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYVR-VENRRFYAEKMGEIVTDRLEENFRE 536 +E SLV+ELEKRGIGRPSTYA IIS +Q R YV + F +G+ V D L + + Sbjct: 512 NEGSLVRELEKRGIGRPSTYAEIISKVQQRAYVEKRDGGAFQPTLLGKFVVDGLVRSNLD 571 Query: 537 LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTS 596 +M+ +FTAQME LD V + + +L F+ F +QLDK++K + T Sbjct: 572 IMDPNFTAQMEEELDAVGAGSLKREQLLKSFYKKFREQLDKSKKLAPW----KPEAEKTD 627 Query: 597 IDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNAL 656 I C CG M + G FL C Y +CK T +L V E + + Sbjct: 628 IVCDECGSMMLKKWGKNGWFLSCERYP-----KCKATRDLSDARGTAAVRETDIS----- 677 Query: 657 RAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGS 716 C KCG M C P C V C CG Sbjct: 678 -----CDKCGKPMII-KTGRFGDFLSCTGYPACKNTRPV----------PLGVACPSCGG 721 Query: 717 EMHLKMGRFG---KYMACT--NEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFV 771 ++ R + C+ N E K K+ + PVP +PC + A FV Sbjct: 722 DLIEIRPRKKGGRTFYGCSNWNAEQKCEFKLWQK---------PVP---VPCPQCGAKFV 769 Query: 772 LRDGAAGVFLAANT 785 R L T Sbjct: 770 TRTAGKKAMLVCAT 783 Score = 92.8 bits (229), Expect = 5e-17, Method: Composition-based stats. Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 6/92 (6%) Query: 703 GYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPEL 761 + + C++CGS M K G+ G +++C +CK TR + A V ++ Sbjct: 622 EAEKTDIVCDECGSMMLKKWGKNGWFLSCERYPKCKATRDLSDARGTAA-----VRETDI 676 Query: 762 PCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 C+K +++ G G FL+ +P + TR Sbjct: 677 SCDKCGKPMIIKTGRFGDFLSCTGYPACKNTR 708 Score = 59.7 bits (143), Expect = 5e-07, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 26/57 (45%) Query: 737 KNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 K R+ L + P + ++ C++ + + + G G FL+ +PK + TR Sbjct: 604 KKFREQLDKSKKLAPWKPEAEKTDIVCDECGSMMLKKWGKNGWFLSCERYPKCKATR 660 >UniRef50_B9L7D9 DNA topoisomerase n=1 Tax=Nautilia profundicola AmH RepID=B9L7D9_NAUPA Length = 728 Score = 681 bits (1756), Expect = 0.0, Method: Composition-based stats. Identities = 289/801 (36%), Positives = 414/801 (51%), Gaps = 89/801 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKA+TI +LG +Y V +S GHIRDLP + K D Sbjct: 1 MAKNLIIVESPAKARTIKNFLGKEYEVVASKGHIRDLPKTSFGIKIEEDK---------- 50 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + Y V + + ELK+ A+KA+ IY+ATD DREGEAI Sbjct: 51 ------------------FIPQYRVTADHQPIAKELKEKAKKAETIYIATDEDREGEAIG 92 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ VIG R+VF+EITK AI++A P ++++RVNAQQARR +DR+VGY +S Sbjct: 93 YHIAHVIGKKPEELPRIVFHEITKTAIKKALENPRTIDLNRVNAQQARRLLDRIVGYKLS 152 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLL KKI +GLSAGRVQS A++LVV+REREIKAF P+E+W ++ G ++ Sbjct: 153 PLLNKKIQKGLSAGRVQSAALKLVVDREREIKAFKPQEYWSIEGIFKKIEGSL--IKYNG 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + F +K++ Q V L+ Y+V E E K TT K APF+TSTLQQ AS+ LGF Sbjct: 211 KKLDKFDIKSKDEAQKIVEELKPLEYTVREIETKTTTVKSPAPFMTSTLQQVASSELGFS 270 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 +KTM +AQ+LYE G ITYMRTDS N++++A +I N G++Y Sbjct: 271 PRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQQAALEFIKQNIGEEYAQAKT 330 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 +N+QEAHEAIRP DV + + LK+ ++ D KLY LI+ +F+A QM AK+++ Sbjct: 331 -YATKNQNAQEAHEAIRPVDVRLTPDDLKNYLKPDELKLYALIFNRFLASQMKDAKFETQ 389 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + + K GR L FDG+ KV K + +LP KG+ L ++ QHFT Sbjct: 390 NIYIANDKGEFKISGRKLIFDGFYKVYG---KPSANTLLPEFEKGEKLKPEDVKATQHFT 446 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPP R++EASL+K+LE GIGRPSTYA I+ +Q+R YV V++++ + ++ V + LE Sbjct: 447 KPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEVKDKKLHPTEIAFSVIETLE 506 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 ++F ++++ +FTA ME LD+VA + +W+ VL F++ F + ++K K+ + Sbjct: 507 KHFPDIVDANFTANMEEMLDEVAEAKKDWQEVLKDFYNPFMELVNKGYKEIPSQKI---- 562 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 CP CG + IR G F+ CS Y +CK T L E Sbjct: 563 AKPIDETCPLCGSPLVIRKGRFGEFIACSSYP-----KCKYTRPLEESKEEKK------- 610 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVEC 711 +C KCG M + C N P C + + V+C Sbjct: 611 ------TDVKCDKCGADMV-VKKGKSGEFLACSNYPKCKNTKPLNAPEVLD-----DVKC 658 Query: 712 EKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYF 770 +CG ++ + R G++ C N +C K PV C + Sbjct: 659 PECGGDIVKRKSRRGEFYGCANYPKCNFI-----------SKYRPV---NKKCPECGYLM 704 Query: 771 VLRDGAAGVFLAANTFPKSRE 791 R K + Sbjct: 705 AERTYRKKDVYEC---IKCKH 722 Score = 105 bits (262), Expect = 7e-21, Method: Composition-based stats. Identities = 29/106 (27%), Positives = 52/106 (49%), Gaps = 9/106 (8%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKED 754 + K C CGS + ++ GRFG+++AC++ +CK TR + + E Sbjct: 555 KEIPSQKIAKPIDETCPLCGSPLVIRKGRFGEFIACSSYPKCKYTRPLEESKEE------ 608 Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 ++ C+K A V++ G +G FLA + +PK + T+ E+ Sbjct: 609 --KKTDVKCDKCGADMVVKKGKSGEFLACSNYPKCKNTKPLNAPEV 652 Score = 62.8 bits (151), Expect = 6e-08, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 29/64 (45%), Gaps = 1/64 (1%) Query: 741 KILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 +++ G P + + C + V+R G G F+A +++PK + TR PL E Sbjct: 548 ELVNKGYKEIPSQKIAKPIDETCPLCGSPLVIRKGRFGEFIACSSYPKCKYTR-PLEESK 606 Query: 801 YRFR 804 + Sbjct: 607 EEKK 610 >UniRef50_Q7NGH1 DNA topoisomerase n=1 Tax=Gloeobacter violaceus RepID=Q7NGH1_GLOVI Length = 765 Score = 680 bits (1755), Expect = 0.0, Method: Composition-based stats. Identities = 304/840 (36%), Positives = 438/840 (52%), Gaps = 110/840 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+LVIVESPAKAKTI+K LG ++VVK+S GHIRDLP Sbjct: 1 MSKSLVIVESPAKAKTISKILGKNFVVKASAGHIRDLPQ--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 MGV+ +++E Y ++P KE+VV ELK A AD +YLA D DREGEAIA Sbjct: 40 --------KEMGVNVKNDFEPKYVIIPKKEEVVEELKGAARNADRVYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ R R+ F+EITK AI+ A P +++I+RV+AQQARR +DR+VGY +S Sbjct: 92 WHLAQILDIPGDRLQRIEFHEITKQAIQNAVAHPRDIDINRVDAQQARRILDRLVGYKLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP---SGEALALQ 237 PLLWKK+ RGLSAGRVQSVAVRL+ +RE+EI+AFV EE+W V + Sbjct: 152 PLLWKKVQRGLSAGRVQSVAVRLLCDREKEIQAFVSEEYWTVHGRFRQSAQVEATPFSAD 211 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + K N+ +A V +L A V + + +P PFITSTLQ+ ++ L Sbjct: 212 LVRWSGKKPDLGNETAARAVVEVLTGAASRVDSVKTRERQKEPQPPFITSTLQREGASAL 271 Query: 298 GFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 G VK+TM +AQ+LYE G ITYMRTDST ++++A R +I +GK Y Sbjct: 272 GLTVKRTMAIAQQLYEGIDLGEEGPVGLITYMRTDSTRVAEEAQEAAREFILAAYGKSYY 331 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 P QY +K+ +Q+AHE +RP+D+N +++K + D KLY+LIW++F A QMT A Sbjct: 332 PSRRRQYGAKKGAQDAHECVRPTDINRPPDAIKKSLTPDQFKLYRLIWQRFTASQMTAAT 391 Query: 408 YDSTTLTVGA------GDFRLKARGRILRFDGWTKVMPALRK----GDEDR--ILPAVNK 455 ++ T+ + A D + FDG+T+V R+ GDE+ P + + Sbjct: 392 LETRTVEIAATPTAGRPDALFRVSVTRTIFDGYTRVYEEAREEAATGDEEAAGAAPVLEE 451 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 G+ALTL+ + P QHFT+PPARFSEA+LVK LE++GIGRPSTYA I TIQ+RGYV + R Sbjct: 452 GEALTLLTVDPKQHFTQPPARFSEATLVKALEEQGIGRPSTYAPTIGTIQERGYVNKDGR 511 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 +G V D+L ++F +++ +FTA ME LD+V W +L F+ F + L Sbjct: 512 TLIPTDLGMKVNDQLVQHFPNIVDTEFTANMEAQLDEVEKGSQRWTQLLADFYGPFVETL 571 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 A+++ + +++T C +CGR + R G FLGCSGY C T Sbjct: 572 KAADEEMKRV------VIVTDHLCESCGRPLLNRYGRFGNFLGCSGYP-----ECDFTHQ 620 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE 695 L +N+ V + AE + C +CG A + C P C + Sbjct: 621 LTRDNK--PVPKDRPAEGIS------CNQCGHAPMLITYGRYGEYLKC---PACGKSQP- 668 Query: 696 EGEFRIKGYDGPIVECEKC-GSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPK 752 + C KC ++ + + GK + C +C Sbjct: 669 ---------KSTGITCPKCSKGQIVERRSKMGKNFYGCDQYPDCDFVLWSR--------- 710 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAG-VFLAANTFPKSRET----RAPLVEELYRFRDRL 807 P+ + C + + + + G +A + + T EE+ R + L Sbjct: 711 ----PIDKPACPECGSILLYKPRKRGDDMVACSA---CKFTAPAQEMVGEEEVERQAELL 763 >UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XK22_MEIRU Length = 836 Score = 679 bits (1752), Expect = 0.0, Method: Composition-based stats. Identities = 297/833 (35%), Positives = 422/833 (50%), Gaps = 115/833 (13%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L++VESPAKAK+I K LG+ Y V++S GHI DLP Sbjct: 5 TLIVVESPAKAKSIQKMLGAGYEVRASKGHIADLPE------------------------ 40 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 + +GVD ++ Y V K+ +V ELK+ A + +ATD DREGEAI WH+ Sbjct: 41 -----HELGVDTQADFAPQYTVKKDKQPIVEELKRAARG-KRVLIATDPDREGEAIGWHV 94 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 ++G + RV F+EIT +R A KP ++ V+AQQARR +DR+VGY +SP+L Sbjct: 95 ARLLGLNPQTPLRVEFHEITPKVVRAAVQKPRPIDQSLVDAQQARRVLDRLVGYQLSPVL 154 Query: 184 WKKIAR-GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH-- 240 + R LSAGRVQSVA+RL+VERE+EI+AFVP+E W ++ + + A+ + Sbjct: 155 SMEFRRRALSAGRVQSVALRLLVEREQEIEAFVPQEHWSLEGRFESEGQQFKAMLYSLGS 214 Query: 241 ---QNDKPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 Q+ F +++Q Q L + Y + E + PFITSTLQQAAS+R Sbjct: 215 ERVQSGDKFLITSEKQAQEIARLAKDVSGYRIGSIERRERRRNAPPPFITSTLQQAASSR 274 Query: 297 LGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LG+ +TM +AQ+LYE G ITYMRTDST +SQ+A+ VR +I +FG YL Sbjct: 275 LGWTASRTMRVAQKLYEGIDLPEGTVGLITYMRTDSTRVSQEALAEVRAFIPRHFGPAYL 334 Query: 349 PESPNQYASKE--NSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTP 405 PE PN +A K+ N+Q+AHEAIRP+ ++L+ + + +LYQLIW++FVA QMTP Sbjct: 335 PEKPNFFAGKKAANAQDAHEAIRPTSTERTPDALRKHLSDEEYRLYQLIWQRFVASQMTP 394 Query: 406 AKYDSTTLTVGA------GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 A +D TT+TV GD +A G +L+FDG+ +V + + LP + + + Sbjct: 395 AVFDQTTVTVVGASGTPSGDLIFRAVGSVLKFDGYLRVYGREEGDEAENRLPPLQENASA 454 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 L+E+TP QHFT+PP R+++ASLVK LE+ GIGRPSTYA I T++ RGY+ + Sbjct: 455 RLLEVTPEQHFTEPPPRYTDASLVKTLEEMGIGRPSTYAPTIDTLERRGYLERSGKSLKP 514 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 +G VT L ++F +++ YDFTAQ+E+ LD++ +A W V+ F+ F + K Sbjct: 515 TPLGREVTGYLIKSFPDVVAYDFTAQLESRLDEIEEGKAAWPKVVREFYEPFLKDFAKVP 574 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPE 639 + CP CGR + ++ + G FLGC+GY CK T L + Sbjct: 575 QKL----------------CPKCGRPLELKVSRFGQFLGCTGYP-----ECKHTERLELK 613 Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF 699 E + E CP CG C P C E Sbjct: 614 KEPEPIGEA-------------CPACGEGQLVRRHGRYGSFISCSRYPECKYTRDE---- 656 Query: 700 RIKGYDGPIVECEKCG-SEMHLKMGRFGK-YMACTNEECKNTRKILRNGEVAPPKEDPVP 757 +EC KC E+ K + GK Y C N C DP+ Sbjct: 657 ----APSTGIECPKCHAGEVVQKTSKRGKPYYRCNNPACDF------------LSFDPL- 699 Query: 758 LPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEK 810 LP+ C V + G +G A P P +E L + R + K Sbjct: 700 LPD-KCPLCGWNEVAK-GRSGK-RACTN-PGCERYGGPKLEALNQRRTKSSSK 748 >UniRef50_C0W9S2 DNA topoisomerase n=1 Tax=Acidaminococcus sp. D21 RepID=C0W9S2_9FIRM Length = 754 Score = 678 bits (1750), Expect = 0.0, Method: Composition-based stats. Identities = 295/751 (39%), Positives = 427/751 (56%), Gaps = 80/751 (10%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LVIVESP K+KTI ++LG +Y VK+S+GH+RDLP S Sbjct: 3 NLVIVESPTKSKTIGRFLGKNYTVKASMGHLRDLPKS----------------------- 39 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 + GVD H++E Y + GK ++ ELK LA+KAD IYLATD DREGEAIAWHL Sbjct: 40 ------QFGVDVDHDFEPKYINIRGKGDLIKELKTLAKKADKIYLATDPDREGEAIAWHL 93 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 ++G D R+ F+EIT +A+++A P +++D+V+AQQ RR +DR+VGY +SPLL Sbjct: 94 GYLLGVDPESNCRISFHEITPHAVKEAIKHPAAIDMDKVDAQQTRRILDRIVGYKLSPLL 153 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS-GEALALQVTHQN 242 W+KIA+GLSAGRVQSVAV+++ +R++EI AF P+E+W + T +VT + Sbjct: 154 WRKIAKGLSAGRVQSVAVKIICDRQKEIDAFEPQEYWTSSVTLTADKPSHKFTAEVTKKE 213 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K N+E+ + L Y+V K +P APF TS+LQQ A RL F K Sbjct: 214 GKKLVIHNEEEARTVTKELLNQSYAVASSAVKDRIRRPIAPFTTSSLQQEAVKRLNFTTK 273 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 KTMM+AQ+LYE G ITYMRTDS +L+ AV +R YI + +G YLP+ PN Sbjct: 274 KTMMLAQQLYEGIALEKRTPVGLITYMRTDSVHLASVAVAEIRNYIGEVYGDAYLPKKPN 333 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 Y+S++N+QEAHEAIRP+ V + + +E D +LY+LIW + V+CQM P+ + TT Sbjct: 334 VYSSRKNAQEAHEAIRPTSVMRTPDEVAPYLERDQLRLYRLIWERTVSCQMAPSVSEVTT 393 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALR-KGDEDRILPAVNKGDALTLVEL-TPAQHF 470 L + G + L+A G ++ FDG+ +M G++ + +P + +G LTL+ + QHF Sbjct: 394 LIINGGPYELRASGSVVNFDGFLTLMDKKELAGEKTKKVPHLKEGTPLTLISVDDAIQHF 453 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PPA F+EA+LVKELE++GIGRPSTYA+II TI RGYV E ++ ++G + L Sbjct: 454 TEPPAYFTEATLVKELEEKGIGRPSTYATIIQTILSRGYVAKEAKKVMPTELGMTTIELL 513 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 + F L++ F+A MEN LD ++ H+ + + VL F+ F ++L+ A+ E ++P Sbjct: 514 TQYFPNLIDVPFSAHMENELDAISEHKTKKETVLKEFYGPFEKELEIAD---REIPVKPQ 570 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 +++++ + C CGR M ++T G FL C G+ C+ T + V Sbjct: 571 EVIVSDVKCEKCGRMMVVKTGRHGKFLACPGFP-----ECRNTKPYYEKIGVA------- 618 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710 CP CG + R + C + P C +D PI E Sbjct: 619 -----------CPLCGHDLIVRKTKTGRTFYGCSHYPEC----------HFTSWDKPINE 657 Query: 711 -CEKCGSEMHLKMGRFGKYM-ACTNEECKNT 739 C CG M + R GK + C+N EC N+ Sbjct: 658 TCPLCGHIMLEAVQRGGKVVHHCSNPECPNS 688 Score = 84.0 bits (206), Expect = 2e-14, Method: Composition-based stats. Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 21/119 (17%) Query: 678 RKLHVCGNNPTCDGYEIEEGEFRIKGYDG--PIVECEKCGSEMHLKMGRFGKYMACTN-E 734 ++ + P EI + E +K + V+CEKCG M +K GR GK++AC Sbjct: 548 KEFYG----PFEKELEIADREIPVKPQEVIVSDVKCEKCGRMMVVKTGRHGKFLACPGFP 603 Query: 735 ECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGV-FLAANTFPKSRET 792 EC+NT+ VA C ++R G F + +P+ T Sbjct: 604 ECRNTKPYYEKIGVA-------------CPLCGHDLIVRKTKTGRTFYGCSHYPECHFT 649 Score = 65.1 bits (157), Expect = 1e-08, Method: Composition-based stats. Identities = 21/82 (25%), Positives = 33/82 (40%), Gaps = 11/82 (13%) Query: 712 EKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFV 771 K E LK +G + +++ P K V + ++ CEK V Sbjct: 539 HKTKKETVLKEF-YGPF----------EKELEIADREIPVKPQEVIVSDVKCEKCGRMMV 587 Query: 772 LRDGAAGVFLAANTFPKSRETR 793 ++ G G FLA FP+ R T+ Sbjct: 588 VKTGRHGKFLACPGFPECRNTK 609 >UniRef50_A0LDV2 DNA topoisomerase I n=7 Tax=Proteobacteria RepID=A0LDV2_MAGSM Length = 783 Score = 677 bits (1747), Expect = 0.0, Method: Composition-based stats. Identities = 304/817 (37%), Positives = 417/817 (51%), Gaps = 111/817 (13%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 A+VIVESPAKAKTINK+LG Y V ++ GHIRDLP+ + Sbjct: 2 TAVVIVESPAKAKTINKFLGRGYKVVATYGHIRDLPSKNGS------------------- 42 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 VD H + Y V K V EL + + A+ + LATD DREGEAI+WH Sbjct: 43 ----------VDTEHGFAMKYSVPKDSTKRVDELAKAVKGAEQVLLATDPDREGEAISWH 92 Query: 123 LREVIGGD----DARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 + EV+ + + RVVF+EITK AI+ A ++++D VNAQQARR +D +VG+ Sbjct: 93 VYEVLNEKKLLENVQVKRVVFHEITKTAIQDAVAHARDVDMDMVNAQQARRALDYLVGFN 152 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS------GE 232 +SPLLW+K+ RGLSAGRVQSVA+RLV ERE EI+AF E+W + A + E Sbjct: 153 LSPLLWRKVRRGLSAGRVQSVALRLVCEREAEIQAFEAREYWSITALAAQAAQSAPRPFE 212 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 A + F ++ + + +EK V E E K + P PFITSTLQQ Sbjct: 213 ARLAVADGEKLSKFSIGDEAYAKRLIKAVEKRPLYVSEIEKKQSKRNPAPPFITSTLQQE 272 Query: 293 ASTRLGFGVKKTMMMAQRLYEA-------------GYITYMRTDSTNLSQDAVNMVRGYI 339 AS +LGF KKTM +AQRLYE G I+YMRTDS NL+ +A+ +R I Sbjct: 273 ASRKLGFSAKKTMTVAQRLYEGMEVPTADGGKETVGLISYMRTDSVNLANEAIESIRKQI 332 Query: 340 SDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQ 397 +GK+YLP+SP +Y S +N+QEAHEAIRP+DV E L++ +E D +LY+LIW++ Sbjct: 333 EIRYGKEYLPKSPRKYKSSAKNAQEAHEAIRPTDVIRTPEMLREILEKDQFRLYELIWKR 392 Query: 398 FVACQMTPAKYDSTTLTVGA------GDFRLKARGRILRFDGWTKVMPALRKG------- 444 VACQM AK D + +R +A G + F G+ KV + Sbjct: 393 TVACQMAQAKIDKVAANLSVDSQDPNAAYRFRATGSSVAFAGFMKVYMEGKDEVSAQDRE 452 Query: 445 ----DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASI 500 D + ILP + G L L QHFT+PP R++EA+LVK LE GIGRPSTYA Sbjct: 453 DDDDDNESILPPLEVGQQLEQKSLDARQHFTEPPPRYTEATLVKVLESYGIGRPSTYAPT 512 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 +ST+QDRGYV+++ R+FY E +G +V L ++F ++Y+FTA +E+ LD V+ E W Sbjct: 513 MSTLQDRGYVKLDARKFYPEDVGMVVNSYLTKHFSTYVDYNFTANLEDQLDAVSRGEKSW 572 Query: 561 KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCS 620 +++ F+ F QQ+ ++ + + Q+ CP CG + I+ G F C+ Sbjct: 573 VPLMEDFWQPFIQQITLKDETTSKEEVTTEQI---DEPCPKCGAPLSIKLGRFGKFKACT 629 Query: 621 GYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 GY CK T L E EV C KCG M K Sbjct: 630 GYP-----ECKHTEPLNKEEEVSR--------PEPELTDIPCDKCGKPMLIKE-GRYGKY 675 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCG-SEMHLKMGRFGK-YMACTN-EECK 737 + C P C + V C CG K R GK + +C+N +CK Sbjct: 676 YGCSGAPECKNNQPLNKPRDTG------VACPSCGQGTFLEKKSRRGKIFYSCSNYPKCK 729 Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRD 774 ++P+ E+PC K A FV + Sbjct: 730 QALW-----------DEPL---EIPCPKCQAPFVTKK 752 Score = 108 bits (270), Expect = 9e-22, Method: Composition-based stats. Identities = 31/108 (28%), Positives = 56/108 (51%), Gaps = 7/108 (6%) Query: 687 PTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRN 745 T + E + D P C KCG+ + +K+GRFGK+ ACT ECK+T + + Sbjct: 587 ITLKDETTSKEEVTTEQIDEP---CPKCGAPLSIKLGRFGKFKACTGYPECKHTEPLNKE 643 Query: 746 GEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 EV+ P+ + L ++PC+K ++++G G + + P+ + + Sbjct: 644 EEVSRPEPE---LTDIPCDKCGKPMLIKEGRYGKYYGCSGAPECKNNQ 688 Score = 62.0 bits (149), Expect = 9e-08, Method: Composition-based stats. Identities = 24/99 (24%), Positives = 37/99 (37%), Gaps = 7/99 (7%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 ++I E +E + PC K A ++ G G F A +P+ + T Sbjct: 583 FIQQITLKDETTSKEEVTTEQIDEPCPKCGAPLSIKLGRFGKFKACTGYPECKHTEPLNK 642 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 EE + PE L D P D G +++ R K Sbjct: 643 EEEVSRPE--PE----LTDIPC-DKCGKPMLIKEGRYGK 674 >UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=TOP1_STAHJ Length = 689 Score = 676 bits (1744), Expect = 0.0, Method: Composition-based stats. Identities = 290/760 (38%), Positives = 427/760 (56%), Gaps = 87/760 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG Y V +S+GH+RDLP Sbjct: 1 MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++MGVD N+E Y + GK VV +LK+ A+KA +++LA+D DREGEAIA Sbjct: 39 -------RSQMGVDVEDNYEPKYITIRGKGPVVKDLKKYAKKAKNVFLASDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ DD++ +RVVFNEITK+A++++F P + +D V+AQQARR +DR+VGY +S Sbjct: 92 WHLSKILELDDSKENRVVFNEITKDAVKESFKHPRGIEMDLVDAQQARRILDRLVGYNIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ +GLSAGRVQSVA+RLV++RE EI+ F PEE+W ++ + + H Sbjct: 152 PVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKSK-FTAKFLH 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 +KPF+ K+ + + L+ ++ + K T P PF TSTLQQ A+ +L F Sbjct: 211 YKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEKTRNPANPFTTSTLQQEAARKLNFK 270 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 +KTMM+AQ+LYE G ITYMRTDST +SQ A + + YI D +GK YL S Sbjct: 271 ARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISQTAKDEAKQYIEDKYGKDYL--S 328 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 K+ Q+AHEAIRP+ +K + D +LY+LIW +FVA QM PA D+ Sbjct: 329 NRTAKGKQGDQDAHEAIRPTSTLRTPYEMKAYLTRDQHRLYKLIWERFVASQMAPAILDT 388 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGDALTLVELTPA 467 L V + + +A G+ ++F G+ + + +++ LP ++KGD +T ++ PA Sbjct: 389 VALDVTQNNIKFRANGQTIKFKGFMTLYVEAKDDKDNEKENKLPNLSKGDEVTATQIEPA 448 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFT+PP R++EA LVK LE+ IGRPSTYA I TIQ R YV++E++RF ++GEIV Sbjct: 449 QHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVY 508 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 +++++ F E+++ +FT ME LD++A + W+ V+D+F+ F +++AE++ E+ + Sbjct: 509 EQVKDYFPEIIDVEFTVNMETLLDKIAEGDIGWRKVIDNFYGSFKLDVERAEEEMEKVEI 568 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 + DC CG M I+ G F+ CS + C+ T +V V Sbjct: 569 KDEPA---GEDCEVCGSPMVIKMGRYGKFMACSNFP-----DCRNTKAIVKTIGVT---- 616 Query: 648 GEDAETNALRAKRRCPKCG-TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDG 706 CPKC + R + C N P CD +D Sbjct: 617 --------------CPKCKDGDVVERKSKKNRLFYGCSNYPECDFI----------SWDK 652 Query: 707 PIV-ECEKCGSE-MHLKMGRFGKYMACTNEECKNTRKILR 744 P+ +C KC M K GR + + C+N C ++ + Sbjct: 653 PVGRDCPKCNHYLMEHKKGRSSQ-VICSN--CDYKEEVQK 689 Score = 85.5 bits (210), Expect = 8e-15, Method: Composition-based stats. Identities = 34/109 (31%), Positives = 49/109 (44%), Gaps = 17/109 (15%) Query: 688 TCDGYEIEEGEFRIKGYDGPIVE-CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRN 745 D EE +++ D P E CE CGS M +KMGR+GK+MAC+N +C+NT+ I++ Sbjct: 553 KLDVERAEEEMEKVEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKT 612 Query: 746 GEVAPPKEDPVPLPELPCEKS-DAYFVLRDGAAGV-FLAANTFPKSRET 792 V C K D V R F + +P+ Sbjct: 613 IGVT-------------CPKCKDGDVVERKSKKNRLFYGCSNYPECDFI 648 Score = 62.0 bits (149), Expect = 1e-07, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 28/60 (46%), Gaps = 4/60 (6%) Query: 741 KILRNGEVAPPKEDPVPLPELP----CEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPL 796 + E A + + V + + P CE + V++ G G F+A + FP R T+A + Sbjct: 551 SFKLDVERAEEEMEKVEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIV 610 >UniRef50_B5YKX8 DNA topoisomerase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YKX8_THEYD Length = 777 Score = 672 bits (1733), Expect = 0.0, Method: Composition-based stats. Identities = 299/854 (35%), Positives = 449/854 (52%), Gaps = 116/854 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L+IVESPAKAKTINK +G D+ VK+S+GHI+DLP Sbjct: 5 GKNLIIVESPAKAKTINKIVGKDFQVKASIGHIKDLPE---------------------- 42 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +R+GVD ++ Y ++PGKEK+V ELK A+ A I++ATD DREGEAIA+ Sbjct: 43 -------DRLGVDIEKGFQPDYIIIPGKEKIVKELKDSAKNAQKIFIATDPDREGEAIAY 95 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ E I + + R +F+EIT NA++ A P +++I++V +QQARR +DR+VGY +SP Sbjct: 96 HIAEEIKVPENKVYRAIFHEITPNAVKAAIANPSKIDINKVYSQQARRILDRLVGYNLSP 155 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG---------- 231 LWKK+ +GLSAGRVQSVA+R+VVERE+EI F PE +W + + Sbjct: 156 FLWKKVKKGLSAGRVQSVALRMVVEREKEILIFQPENYWTIVGNFKNDENLKELRANLYK 215 Query: 232 -EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 + + + F ++E Q + L+K Y + + E K P PF T+TLQ Sbjct: 216 YKGKLIIDRKEEKAKFLITDEETAQKIIEELKKLNYILTKVEKKKKKKNPPEPFRTATLQ 275 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 AS+ LGF KKTMM+AQ+LYE G ITYMRTDST ++++A + I N Sbjct: 276 AQASSTLGFSPKKTMMLAQQLYEGIDIEGTRIGLITYMRTDSTRVAEEAKKWAKNIIEKN 335 Query: 343 FGKKYLPESPNQYASKENS--QEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFV 399 FGK+++ K+ + Q+AHE IRP+ + ES+K + + LY+LIW +F+ Sbjct: 336 FGKEFVGNHKIHETKKQKTPIQDAHECIRPTYPDKSPESIKKYLTKEQYSLYKLIWDRFL 395 Query: 400 ACQMTPAKYDSTTLTVGAGD--FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 A QM+PA+ + TT + D + + G ++ F G+ + + +ED +LP +N+ Sbjct: 396 ASQMSPAEVEQTTYIIEDLDSIAQFRVTGSVITFPGFLIIYK-DEESEEDTVLPQLNEKT 454 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 +L + EL +H T+PP R++EA+LVK LE++GIGRPSTYA+I+STIQ+RGYV+ ++ Sbjct: 455 SLKISELEAQKHTTEPPPRYTEATLVKALEEKGIGRPSTYATILSTIQERGYVKKVKQKL 514 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 +G +V D LEE F ELM+Y FTA+ME LD+++ +EA+W V++ F+ +F LD+ Sbjct: 515 QPTYLGFVVNDLLEEKFPELMDYSFTAKMEEDLDKISLNEAKWNKVIEEFYKEFENDLDQ 574 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV 637 A K + + + TS C CG+ M IR + FL CSGY CK T +L Sbjct: 575 ASKISKVIK---PKEIKTSFKCEKCGKDMVIRWSKGVPFLACSGYP-----ECKNTRSL- 625 Query: 638 PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEG 697 + + ++CP+CG + + + C N P C + Sbjct: 626 ---------NNNENGSTKKTLDKKCPQCGAQLVVR-NGKRGEFIACSNYPKCKFTQSITA 675 Query: 698 EFRIKGYDGPIVECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDP 755 + V+C +CG ++ K + G+ + AC N +CK T +P Sbjct: 676 Q----------VKCPQCGGDILKKQTKKGRTFWACANYPKCKFTLS-----------NEP 714 Query: 756 VPLPELPCEKSD-AYFVLRDGAAG-VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRY 813 VP C K +Y + + G FL + + ++ K Sbjct: 715 VPAE---CPKCKSSYMLKKKDRNGTEFLICHN---------------KACKGKIEIKEHS 756 Query: 814 LADAPQQDPEGNKT 827 P Q + N Sbjct: 757 TGTDPAQQKDANPA 770 >UniRef50_A6DDI1 DNA topoisomerase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DDI1_9PROT Length = 725 Score = 671 bits (1732), Expect = 0.0, Method: Composition-based stats. Identities = 285/803 (35%), Positives = 422/803 (52%), Gaps = 90/803 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP+KA+TI +LG +Y V +S GHIRDLP + K D Sbjct: 1 MAKKLIIVESPSKARTIKNFLGKEYEVIASKGHIRDLPKTSFGIKIEEDK---------- 50 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + Y V + V ELK+ A+KA+ IY+ATD DREGEAI Sbjct: 51 ------------------FIPQYRVTKDHQSVAKELKEKAKKAETIYIATDEDREGEAIG 92 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ VIG D + R+VF+EITK AI+ A P +L+IDRVNAQQARR +DR+VGY +S Sbjct: 93 FHIAHVIGKDPSSLPRIVFHEITKTAIKNALKNPRKLDIDRVNAQQARRLLDRIVGYKLS 152 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLL KKI +GLSAGRVQS A++LVV+REREIK F+P+E+W ++ G ++ Sbjct: 153 PLLNKKIQKGLSAGRVQSAALKLVVDREREIKEFIPKEYWSIEGIFKEVEGNL--IKYNG 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + F +++ + V+ L+ Y V + E K TT+K APF+TSTLQQ AS+ LGF Sbjct: 211 KKLEKFDLKTRDEAEKIVNELKPLEYEVSKIEKKTTTTKSPAPFMTSTLQQVASSELGFS 270 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 +KTM +AQ+LYE G ITYMRTDS N++++A +I +N G +Y E+ Sbjct: 271 PRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQEAAINFIKENIGSEY-AEAK 329 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 + +QEAHEAIRP DV + + LK+ + D KLY LI+ +F+A QM AK+++ Sbjct: 330 TYTTKNQTAQEAHEAIRPVDVRLTPDDLKNYLSKDELKLYSLIYNRFLASQMKDAKFETQ 389 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + + K G+ L FDG+ KV K D +LP +G+ L E+ QHFT Sbjct: 390 NIYLTNEKGEFKISGKKLIFDGFYKVYG---KRGADTLLPEFKEGEKLKPEEIKATQHFT 446 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPP R++EASL+K+LE GIGRPSTYA I+ +Q+R YV +++++ + ++ V + LE Sbjct: 447 KPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEIKDKKLHPTEIAFNVIETLE 506 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 ++F ++++ FTA ME LD++A +W+ +L F++ F + ++K ++ + Sbjct: 507 KHFPDIVDAKFTANMEEMLDEIARGNKDWQEMLKEFYNPFMKLIEKGYEEIPSQKI---- 562 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 T CP CG + IR G F+ CS + +CK T + + E Sbjct: 563 AKPTGELCPECGNPLVIRKGRFGEFIACSNFP-----KCKYTRPIEEKEEK--------- 608 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVEC 711 + +C KCG M + C N P C + ++ V+C Sbjct: 609 -----KVDVKCDKCGADMVIKRGKRG-EFLACSNYPECKNTKPLNPPEVLE-----DVKC 657 Query: 712 EKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYF 770 +CG ++ + R G++ C N +C K PV C++ Sbjct: 658 PECGGDIIKRKSRRGEFYGCGNYPKCNFI-----------SKYRPV---NEKCDECGYMM 703 Query: 771 VLRDGAAGVFLAANTFPKSRETR 793 R L K + + Sbjct: 704 AKRTYRNKEVLEC---IKCKARK 723 Score = 110 bits (276), Expect = 2e-22, Method: Composition-based stats. Identities = 30/106 (28%), Positives = 51/106 (48%), Gaps = 10/106 (9%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKED 754 E K C +CG+ + ++ GRFG+++AC+N +CK TR I E Sbjct: 555 EEIPSQKIAKPTGELCPECGNPLVIRKGRFGEFIACSNFPKCKYTRPIEEKEE------- 607 Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 ++ C+K A V++ G G FLA + +P+ + T+ E+ Sbjct: 608 --KKVDVKCDKCGADMVIKRGKRGEFLACSNYPECKNTKPLNPPEV 651 Score = 65.1 bits (157), Expect = 1e-08, Method: Composition-based stats. Identities = 16/63 (25%), Positives = 26/63 (41%) Query: 741 KILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 K++ G P + C + V+R G G F+A + FPK + TR +E Sbjct: 548 KLIEKGYEEIPSQKIAKPTGELCPECGNPLVIRKGRFGEFIACSNFPKCKYTRPIEEKEE 607 Query: 801 YRF 803 + Sbjct: 608 KKV 610 >UniRef50_Q2FZ32 DNA topoisomerase 1 n=260 Tax=Bacteria RepID=TOP1_STAA8 Length = 689 Score = 670 bits (1728), Expect = 0.0, Method: Composition-based stats. Identities = 287/759 (37%), Positives = 425/759 (55%), Gaps = 85/759 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG Y V +S+GH+RDLP Sbjct: 1 MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++MGVD N+E Y + GK VV ELK+ A+KA +++LA+D DREGEAIA Sbjct: 39 -------RSQMGVDTEDNYEPKYITIRGKGPVVKELKKHAKKAKNVFLASDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ +D++ +RVVFNEITK+A++++F P E+ ++ V+AQQARR +DR+VGY +S Sbjct: 92 WHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMNLVDAQQARRILDRLVGYNIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ +GLSAGRVQSVA+RLV++RE EI+ F PEE+W ++ + + H Sbjct: 152 PVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKSK-FNAKFLH 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 +KPF+ K+ + + L+ ++ + K T P PF TSTLQQ A+ +L F Sbjct: 211 YKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAARKLNFK 270 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 +KTMM+AQ+LYE G ITYMRTDST +S A + YI+D +G+ Y S Sbjct: 271 ARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKVEAKQYITDKYGESY--TS 328 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 + + K+ Q+AHEAIRPS + +K + D +LY+LIW +FVA QM PA D+ Sbjct: 329 KRKASGKQGDQDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWERFVASQMAPAILDT 388 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG---DEDRILPAVNKGDALTLVELTPA 467 +L + GD + +A G+ ++F G+ + + +++ LP + +GD +T ++ PA Sbjct: 389 VSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLEQGDKVTATQIEPA 448 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QH+T+PP R++EA LVK LE+ IGRPSTYA I TIQ R YV++E++RF ++GEIV Sbjct: 449 QHYTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVH 508 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 ++++E F E+++ +FT ME LD++A + W+ V+D FFS F Q +++AE++ E+ + Sbjct: 509 EQVKEYFPEIIDVEFTVNMETLLDKIAEGDITWRKVIDGFFSSFKQDVERAEEEMEKIEI 568 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 + DC CG M I+ G F+ CS + C+ T +V V Sbjct: 569 KDEPA---GEDCEICGSPMVIKMGRYGKFMACSNFP-----DCRNTKAIVKSIGV----- 615 Query: 648 GEDAETNALRAKRRCPKCG-TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDG 706 +CPKC + R + C P CD +D Sbjct: 616 -------------KCPKCNDGDVVERKSKKNRVFYGCSKYPECDFI----------SWDK 652 Query: 707 PIV-ECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILR 744 PI +C KC + + C+N C + Sbjct: 653 PIGRDCPKCNQYLVENKKGKTTQVICSN--CDYKEAAQK 689 Score = 80.5 bits (197), Expect = 2e-13, Method: Composition-based stats. Identities = 36/107 (33%), Positives = 51/107 (47%), Gaps = 17/107 (15%) Query: 690 DGYEIEEGEFRIKGYDGPIVE-CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGE 747 D EE +I+ D P E CE CGS M +KMGR+GK+MAC+N +C+NT+ I+++ Sbjct: 555 DVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACSNFPDCRNTKAIVKSIG 614 Query: 748 VAPPKEDPVPLPELPCEKS-DAYFVLRDGAA-GVFLAANTFPKSRET 792 V C K D V R VF + +P+ Sbjct: 615 V-------------KCPKCNDGDVVERKSKKNRVFYGCSKYPECDFI 648 Score = 59.0 bits (141), Expect = 9e-07, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 19/34 (55%) Query: 763 CEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPL 796 CE + V++ G G F+A + FP R T+A + Sbjct: 577 CEICGSPMVIKMGRYGKFMACSNFPDCRNTKAIV 610 >UniRef50_D1B6D6 DNA topoisomerase I n=3 Tax=Synergistaceae RepID=D1B6D6_THEAS Length = 708 Score = 669 bits (1726), Expect = 0.0, Method: Composition-based stats. Identities = 269/709 (37%), Positives = 389/709 (54%), Gaps = 74/709 (10%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LV+VESP KAK+++K LG Y V++S+GH+ DLP Sbjct: 44 TLVVVESPTKAKSLSKMLGPGYAVEASLGHVMDLPKV----------------------- 80 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 R+GVD + +E Y + GK V+ LK+LA A + LA+D DREGEAIAWHL Sbjct: 81 ------RLGVDVENGFEPEYIQVRGKGPVIKRLKELARGASRVLLASDPDREGEAIAWHL 134 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 ++G RV +EIT + I A + +++++V AQQARR +DR+VGY +SPLL Sbjct: 135 ATLLGVPLDSPCRVRIHEITPSGISAALQEVEGIDMNKVYAQQARRVLDRLVGYRLSPLL 194 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 W K+ RGLSAGRVQSVA+RLV ERE EI +FVPEE+W V+ G + L++ + Sbjct: 195 WAKVQRGLSAGRVQSVALRLVCEREDEIDSFVPEEYWLVEVQAEAEGGRSYLLKLDKEAG 254 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 KP R ++ + +L+ + V + +P PF TSTLQQ AS RLG+G ++ Sbjct: 255 KPVRLKDQADARRVEALVRSSPLQVSSFRSRDGLRRPMPPFKTSTLQQEASRRLGYGPRR 314 Query: 304 TMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 TM +AQ L+E G ITYMRTDS +S +A++ +RG+I+ FG YLPE PN Sbjct: 315 TMRIAQSLFEGVEIPGRGPVGLITYMRTDSLRISDEAISAMRGHIASRFGPMYLPERPNH 374 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 +A K SQ+AHEAIRP+DV + +++++ + ++ +LY LIWR+ +A QM A+ + TL Sbjct: 375 FAQKGRSQDAHEAIRPTDVTLEPDAIREYLSSEQYRLYDLIWRRALASQMADARVRTNTL 434 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKP 473 G+ K G + F GW V P K E +PA ++G+ L +++ Q FT+P Sbjct: 435 EARCGELTFKCSGVEVTFQGWGAVWPLGVKDTE---VPAASEGEDLRPLQVRLEQKFTQP 491 Query: 474 PARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRLEE 532 P R++EA L+K LE++GIGRPSTYA+I+ T+ DRGYV ++++ K+G +V L Sbjct: 492 PGRYTEAGLIKALEEKGIGRPSTYATIVETLSDRGYVVRDDDKKLSPTKLGRVVNAFLVT 551 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 +F +++ DFTA+ME+ LD+V + E +W+ + F+ F +L + + + P Sbjct: 552 HFPDVVQVDFTARMEDQLDRVESGEIQWREPIGDFYGPFESRLQEVAASAQRMTVPPE-- 609 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 L DCP CGR + IR G F+GCSGY + K T VP Sbjct: 610 -LAGEDCPQCGRPLLIRRGRYGEFIGCSGYPECDFTKRKETSTGVP-------------- 654 Query: 653 TNALRAKRRCPKCGTAMD-----SYLIDPKRKLHVCGNNPTCDGYEIEE 696 CPKCG S R + C P CD + Sbjct: 655 ---------CPKCGQGTVVARKASKGKGKGRTFYGCSRYPECDYVSWSK 694 Score = 79.4 bits (194), Expect = 6e-13, Method: Composition-based stats. Identities = 18/95 (18%), Positives = 37/95 (38%), Gaps = 20/95 (21%) Query: 702 KGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPE 760 + +C +CG + ++ GR+G+++ C+ EC T++ + Sbjct: 606 VPPELAGEDCPQCGRPLLIRRGRYGEFIGCSGYPECDFTKRKETS-------------TG 652 Query: 761 LPCEKSD-AYFVLRDGAAGV-----FLAANTFPKS 789 +PC K V R + G F + +P+ Sbjct: 653 VPCPKCGQGTVVARKASKGKGKGRTFYGCSRYPEC 687 Score = 63.2 bits (152), Expect = 5e-08, Method: Composition-based stats. Identities = 9/39 (23%), Positives = 17/39 (43%) Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 P L C + ++R G G F+ + +P+ T+ Sbjct: 607 PPELAGEDCPQCGRPLLIRRGRYGEFIGCSGYPECDFTK 645 >UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LM02_9FIRM Length = 799 Score = 668 bits (1723), Expect = 0.0, Method: Composition-based stats. Identities = 283/780 (36%), Positives = 407/780 (52%), Gaps = 78/780 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L+IVESPAKAKTI + LGSDY V +S+GH+RDLP Sbjct: 31 GKHLIIVESPAKAKTIERILGSDYKVLASMGHLRDLPQ---------------------- 68 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +GVD ++++ Y + V+ L++ A K+ I LATD DREGEAI+W Sbjct: 69 -------RTLGVDVANDFKPEYVSSAERADVIENLQKEANKSKDILLATDPDREGEAISW 121 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL +++ D +R+ F+EIT AI++A P ++++RV+AQQARR +DR+VGY +SP Sbjct: 122 HLSKLLDVDPRSNARIAFHEITPPAIKEAVLHPEPIDLNRVDAQQARRVLDRLVGYKLSP 181 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LWK+I RGLSAGRVQSVA RL+ ERE EI+AF P E+W V+ T E+ ++T Sbjct: 182 WLWKQIYRGLSAGRVQSVATRLICEREEEIRAFKPVEYWTVEGIYRTEEKESFKAKLTQV 241 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + K + N E+ V + K + K P+ TST+QQ A RL FG Sbjct: 242 DGKEAKINNAEEADRVVRGILKQPAEITSVTKTKKQRKAKPPYTTSTMQQDAVNRLNFGS 301 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KKTM +AQ LYE G ITYMRTDST +S + + VR YI +GK YLP P Sbjct: 302 KKTMALAQMLYEGIEIPGHGHVGLITYMRTDSTRISDEMIKQVRPYIERVYGKDYLPPKP 361 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 N YA ++SQ+AHEAIRP+++ + L + D +LY LIW +F+A QM P +T Sbjct: 362 NVYARGKDSQDAHEAIRPTNLQFAPDMLAAVLSRDQLRLYTLIWNRFLASQMAPQISQAT 421 Query: 412 TLTVGAGDFRLKARGRILRFDGWT---KVMPALRKGDEDRILPAVNKGDALTLVELTPAQ 468 + +G + L+A G + FDG+T V + +E ILPA++KG + + Q Sbjct: 422 NAVLQSGIYTLRATGTQILFDGFTVLRTVKEKKQDNEELPILPALHKGHTVLNTKAEGEQ 481 Query: 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528 HFT PP R++EASL+K LE++GIGRPSTYA I+ TIQ R YV E ++F +G VTD Sbjct: 482 HFTAPPPRYTEASLIKTLEEKGIGRPSTYAPILDTIQRRKYVEKEGKQFVPTDIGFKVTD 541 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 L++ F +++ DFTAQ+E LD++A+ +A +K V+ F+ F ++L A + E + Sbjct: 542 LLKKYFAGIVSVDFTAQLETWLDKIADGKATYKKVMSGFWDVFEKELQNA--NLEAAKAK 599 Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPP--------------------KE 628 ++ + C CG M ++ + G +L C + K Sbjct: 600 EENQEVSDVICEKCGAHMIVKMSRYGKYLACPNFPSCKNIKPYHTGEEKEEISDVDCDKC 659 Query: 629 RCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA-MDSYLIDPKRKLHVCGNNP 687 K P L E + + CPKC + R + C P Sbjct: 660 GAKMVYRQGPYGRYLKCPECGQNKAIVIDTGIECPKCHEGHLVKRRSKRGRYFYGCSRYP 719 Query: 688 TCDGYEIEEGEFRIKGYDGPIVE-CEKCGSEMHLKMGRFG-KYMACTNEECKNTRKILRN 745 CD + +D P+ E C CG+ K+ + + + C+N EC T + Sbjct: 720 ACD----------MAVWDEPVNEFCSVCGAIKVKKVRKNKEEELICSNPEC-TTHPKKKT 768 Score = 84.0 bits (206), Expect = 3e-14, Method: Composition-based stats. Identities = 31/109 (28%), Positives = 53/109 (48%), Gaps = 11/109 (10%) Query: 691 GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVA 749 +E + + + + V CEKCG+ M +KM R+GKY+AC N CKN + Sbjct: 590 NANLEAAKAKEENQEVSDVICEKCGAHMIVKMSRYGKYLACPNFPSCKNIKPYH------ 643 Query: 750 PPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVE 798 E+ + ++ C+K A V R G G +L P+ + +A +++ Sbjct: 644 -TGEEKEEISDVDCDKCGAKMVYRQGPYGRYLKC---PECGQNKAIVID 688 >UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YFC7_DICT6 Length = 694 Score = 664 bits (1712), Expect = 0.0, Method: Composition-based stats. Identities = 278/767 (36%), Positives = 408/767 (53%), Gaps = 88/767 (11%) Query: 1 MGK-ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKP 59 M K L+IVESPAKAKTI K LG D+ V +S GHIRDLP Sbjct: 1 MSKEKLIIVESPAKAKTIEKILGKDFKVLASYGHIRDLPE-------------------- 40 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 +GVD + ++ Y +LP ++K++ +K L++K + +YLATD DREGEAI Sbjct: 41 ---------KELGVDIENGFKPKYVLLPSRKKIIDTIKDLSKKVEKLYLATDPDREGEAI 91 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 AWHL E + +++R+ F+EIT AI++A P ++++D+V AQQARR +DR+VGY + Sbjct: 92 AWHLVETLKLPKDKFTRIEFHEITPRAIQEAIRNPRDIDLDKVEAQQARRILDRLVGYEL 151 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SPLLW+K+ RGLSAGRVQSVA++L+ ERE EI+ FVPEE+W + + + ++ Sbjct: 152 SPLLWEKVRRGLSAGRVQSVALKLICEREEEIEKFVPEEYWYIYGEFEDKD-KIIYGKLV 210 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 ++ N+++ + + +L Y + K P PFITSTLQQ AS RLGF Sbjct: 211 FYKEEEITIRNEKEAKRLIEVLNNLEYKIDRVVIKEEKKTPPLPFITSTLQQEASRRLGF 270 Query: 300 GVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 V KTM +AQ LYE G ITYMRTDST ++ +A YI FGK+Y+ + Sbjct: 271 PVSKTMKIAQSLYEGVDIGDERVGLITYMRTDSTRIAPEAREEAVTYIESVFGKEYVGKE 330 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 + K Q+AHEAIRP+ V E +K + D KLY+LIW +F+A QM A YD Sbjct: 331 -RKERKKLGMQDAHEAIRPTSVLRTPEKVKKYLTEDQYKLYKLIWERFLASQMANALYDV 389 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI----LPAVNKGDALTLVELTP 466 + + GD+ ++GR L+F G+ + + +E+ + +P +G + L+ LTP Sbjct: 390 IEIDIKGGDYTFVSKGRKLKFAGFMSLYTEKEEEEEEEVNVDYIP--QEGSDIDLINLTP 447 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 Q FT+PP R++EA+LV+ LEK GIGRPSTYA+II T+++R YV V + +G++V Sbjct: 448 KQFFTQPPPRYTEATLVRTLEKYGIGRPSTYATIIETLKERKYVEVSKKELVPTTLGKVV 507 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG 586 + L + F L++ FTA+ME LD++ + E + VL+ F+ F ++L++ K+ + Sbjct: 508 NEFLTKQFPHLIDVKFTAKMEEDLDKIESGEVKAIEVLEKFYPSFKEELERVSKNFGKIQ 567 Query: 587 MRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVL 646 + + T CP CGR++ IR G + CS Y CK T + E Sbjct: 568 V----VEKTDEFCPICGRELVIRENKHGKYYACSAYP-----ECKYTKPIYEE------- 611 Query: 647 EGEDAETNALRAKRRCPKCGTAMDSYLIDPKRK-LHVCGNNPTCDGYEIEEGEFRIKGYD 705 A +CP CG + K C N P C Y+ Sbjct: 612 -----------AHGKCPLCGGIVVKKKARKTGKVFWGCINYPNCSFA---------SPYE 651 Query: 706 GPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 +C +CGS + G + C+NE C + R K Sbjct: 652 PLDEKCPQCGSVLLKGNG----FKKCSNENCNYIVWVGRRKRWKKSK 694 Score = 69.0 bits (167), Expect = 7e-10, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 33/101 (32%), Gaps = 16/101 (15%) Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAP 750 + + +I+ + C CG E+ ++ + GKY AC+ ECK T+ I Sbjct: 557 ERVSKNFGKIQVVEKTDEFCPICGRELVIRENKHGKYYACSAYPECKYTKPIYEEAHG-- 614 Query: 751 PKEDPVPLPELPCEKSDAYFVLRDGAA--GVFLAANTFPKS 789 C V + VF +P Sbjct: 615 -----------KCPLCGGIVVKKKARKTGKVFWGCINYPNC 644 Score = 57.8 bits (138), Expect = 2e-06, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 23/50 (46%), Gaps = 1/50 (2%) Query: 752 KEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELY 801 K V + C V+R+ G + A + +P+ + T+ P+ EE + Sbjct: 565 KIQVVEKTDEFCPICGRELVIRENKHGKYYACSAYPECKYTK-PIYEEAH 613 >UniRef50_B3EPW7 DNA topoisomerase n=12 Tax=Chlorobiaceae RepID=B3EPW7_CHLPB Length = 804 Score = 662 bits (1709), Expect = 0.0, Method: Composition-based stats. Identities = 293/769 (38%), Positives = 413/769 (53%), Gaps = 86/769 (11%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L++VESP+KAKTINKYLGSDY+V +SVGHI+DLP Sbjct: 12 GKTLIVVESPSKAKTINKYLGSDYLVFASVGHIKDLPK---------------------- 49 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +G+D +N+E YEV+ GKEKVV +LK+LA +A+ I +ATD DREGEAIAW Sbjct: 50 -------KEIGLDFDNNYEPRYEVISGKEKVVRQLKKLAGQANDILIATDPDREGEAIAW 102 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ + RV+FNEITK AI +A N P +++ V +QQ R+ +D++VGY +SP Sbjct: 103 HIANEVDAAQKPVHRVLFNEITKKAILEAINDPLQIDYRLVRSQQTRQGLDKIVGYKISP 162 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LW + RGLSAGRVQSV++RL+ ERE EI F P+E+W + A TT SGE + ++ Sbjct: 163 FLWNVVMRGLSAGRVQSVSLRLICEREAEIDKFEPKEYWTIFADFTTGSGETFSTKLVRI 222 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + N+ + S + Y V E + KP PF TS LQQAAS +LGFG Sbjct: 223 DSNKAEITNQSDAEKTASDILSRIYGVAEITPRVQQRKPPFPFTTSLLQQAASNQLGFGS 282 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KKTM +AQ+LYE G ITYMRTDST +S +AV +I+ +FG ++ Sbjct: 283 KKTMRVAQQLYEGIDLGPEGATGLITYMRTDSTRVSGEAVEQAERFITQHFGPEFTGGGQ 342 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 K+ +Q+AHEAIRP+ V E++K + +D KLY+LIW++F+A +M PAK + T Sbjct: 343 AAKKGKK-TQDAHEAIRPTGVPRTPETMKPFLSSDQYKLYELIWKRFLASRMAPAKIEQT 401 Query: 412 TLTVGAGD--FRLKARGRILRFDGWTKVMPALRK----------GDEDRI----LP-AVN 454 + V + F +A G + F G+ KV ++ DE++ LP + Sbjct: 402 RVDVADHEKQFIFRASGSNVLFPGFLKVYNEQKELDYEARKSTREDEEKEQIVKLPRNLT 461 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN 514 + LTL L Q FT+PPARF+EASLVKEL+ GIGRPSTYA I ST+QDR YV +E Sbjct: 462 VNEKLTLDTLDKKQSFTRPPARFTEASLVKELDNYGIGRPSTYAGIFSTLQDRRYVELEK 521 Query: 515 RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQ 574 ++ ++G+ V+ L NF +L N FTA MEN LD++A + E++ VLD F+ Sbjct: 522 KKIIPTELGKDVSMILVANFPDLFNVTFTAHMENELDKIAAGDDEYEQVLDSFYKPLESA 581 Query: 575 LDKAEKDPEEGGMRPNQMVLTSIDCPTCGR-KMGIRTASTGVFLGCSGYALPPKERCKTT 633 L + DP + C CG+ KM I+ ++G FLGCS Y CK Sbjct: 582 LSVRKNDPLL------PQNTDAETCDKCGKGKMIIKWTASGKFLGCSSYPA-----CKNI 630 Query: 634 INLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE 693 L +C C C P C+ Sbjct: 631 KPLASSR------------VRPKETGIKCHGCENGRMVLRNGRFGPFLACTGYPDCNTLL 678 Query: 694 IEEGEFRIKGYDGPIVE----CEKCGSEMHLKMGRFGKYMACTN-EECK 737 + + +I+ P +E C KCG+ ++L+ G+ G ++ C+ +C+ Sbjct: 679 KLDKQRKIEPPKTPPLETDLACPKCGAPLYLRTGKRGLWLGCSKFPKCR 727 Score = 139 bits (351), Expect = 4e-31, Method: Composition-based stats. Identities = 43/162 (26%), Positives = 64/162 (39%), Gaps = 6/162 (3%) Query: 635 NLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEI 694 P L+V + + A C KCG K C + P C + Sbjct: 574 FYKPLESALSVRKNDPLLPQNTDA-ETCDKCGKGKMIIKWTASGKFLGCSSYPACKNIKP 632 Query: 695 EEGEFRIKGYDGPIVECEKC-GSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPK 752 ++C C M L+ GRFG ++ACT +C K+ + ++ PPK Sbjct: 633 LASSR--VRPKETGIKCHGCENGRMVLRNGRFGPFLACTGYPDCNTLLKLDKQRKIEPPK 690 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 P+ +L C K A LR G G++L + FPK R +A Sbjct: 691 TPPLE-TDLACPKCGAPLYLRTGKRGLWLGCSKFPKCRGRQA 731 >UniRef50_C1ABE5 DNA topoisomerase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1ABE5_GEMAT Length = 816 Score = 661 bits (1705), Expect = 0.0, Method: Composition-based stats. Identities = 287/823 (34%), Positives = 419/823 (50%), Gaps = 111/823 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G +LVIVESPAKAKTI KYLG Y VK++VGH+RDLP Sbjct: 49 GTSLVIVESPAKAKTIGKYLGRGYTVKATVGHVRDLP----------------------- 85 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++G+D H + Y + GKE ++++LK++A+ A I++ATD DREGEAI W Sbjct: 86 ------AKKLGIDIDHGFAPEYVTIEGKEDILTDLKKVAKGAREIFIATDPDREGEAIGW 139 Query: 122 HLREVIGGDD-----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 H+ + A RV+F+EITK+A+ ++ KP +++ +V AQQARR +DR+VG Sbjct: 140 HVEQYFTQPKRHAVSAPIRRVMFHEITKDAVHKSMAKPMDIDNKKVEAQQARRVLDRLVG 199 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 Y SP+LWK + +GLSAGRVQ+VA+RL+VEREREI+AF P E+W + A + Sbjct: 200 YKASPVLWKTVKKGLSAGRVQTVALRLIVEREREIRAFTPVEYWSIAADLQK-GQQPFTA 258 Query: 237 QVTHQNDKPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFITSTLQQAAST 295 ++ + K N + + ++ L + + V E + + P APF TSTLQQ A+ Sbjct: 259 KLHQLDGKKPEIGNGTEAERIIADLAGRKEFVVTEVKRRERRKNPAAPFTTSTLQQEAAK 318 Query: 296 RLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 +LGFG K+TM +AQ LYE G ITYMRTDST +S+DA N R + FG Sbjct: 319 KLGFGSKRTMRLAQDLYEGIDVGIDGATGLITYMRTDSTRVSEDAANSARESLRAQFGDD 378 Query: 347 YLPESPNQYASKE-NSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMT 404 +L +P Y S + N+Q+AHE +RP+D + E ++ + AD KLYQLIW++F+A QM Sbjct: 379 FLAPAPQLYPSGKANAQDAHEGVRPTDPSRRPEQVQKFLTADQFKLYQLIWQRFMASQMA 438 Query: 405 PAKYDSTTLTVGA--------GDFRLKARGRILRFDGWTKVMPALRKG------DEDRIL 450 PA +D+TT+ ++ +A G +++F G+ + R+ ++++ L Sbjct: 439 PAVFDTTTVDFNIPIKVADAERNYLFRATGSVVKFQGFLALYREAREEGDAKALEDEQAL 498 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 P + + + + +TP QHFT+PP RFSEASLVKELE+ GIGRPSTYASIIS + +R YV Sbjct: 499 PVLEVDERVPVKAITPTQHFTEPPPRFSEASLVKELERAGIGRPSTYASIISVLVERRYV 558 Query: 511 RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 +E RRF+ +GE V + + F ++ N FTAQME LD++A E +W L F++ Sbjct: 559 SLEQRRFFPTSLGETVEKVMVKKFPDVFNVGFTAQMEEELDKIAEGEIDWVRALGDFWTP 618 Query: 571 FTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERC 630 F + L+ + D G + L + CP CG K+ + G F+ C + + C Sbjct: 619 FQRTLNDNDLDALIGEAY-DLSALETERCPDCGGKLVAKGGFFGPFVACENHP----KAC 673 Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCD 690 K T + E + A C +CG M C P C Sbjct: 674 KYTRPIKGEKK------------PAELTNYMCQECGAPMVIRH-GRSGDFLGCSKFPKCR 720 Query: 691 GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRF-GK-YMACTN-EECKNTRKILRNGE 747 G V+C K G E+ + + GK + C N C E Sbjct: 721 GTRSM----------PTGVKCPKDGGEIAERRSKKRGKAFYGCENYPNCDFVVWDKPVAE 770 Query: 748 VAPPKEDPVPLPELPCEKSD--AYFVLRDGAAGVF---LAANT 785 C + + G F L + Sbjct: 771 --------------TCPECGYVGAEAKSNKTRGSFRKCLKCSN 799 Score = 103 bits (257), Expect = 3e-20, Method: Composition-based stats. Identities = 31/90 (34%), Positives = 44/90 (48%), Gaps = 9/90 (10%) Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTN--EECKNTRKILRNGEVAPPKEDPVPLPELPCE 764 C CG ++ K G FG ++AC N + CK TR I ++ P L C+ Sbjct: 642 ETERCPDCGGKLVAKGGFFGPFVACENHPKACKYTRPIKG-------EKKPAELTNYMCQ 694 Query: 765 KSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 + A V+R G +G FL + FPK R TR+ Sbjct: 695 ECGAPMVIRHGRSGDFLGCSKFPKCRGTRS 724 Score = 45.5 bits (106), Expect = 0.008, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 17/56 (30%), Gaps = 1/56 (1%) Query: 739 TRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPK-SRETR 793 T + D L C V + G G F+A PK + TR Sbjct: 622 TLNDNDLDALIGEAYDLSALETERCPDCGGKLVAKGGFFGPFVACENHPKACKYTR 677 >UniRef50_Q01N68 DNA topoisomerase n=7 Tax=Bacteria RepID=Q01N68_SOLUE Length = 934 Score = 654 bits (1686), Expect = 0.0, Method: Composition-based stats. Identities = 310/842 (36%), Positives = 451/842 (53%), Gaps = 88/842 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M KALVIVESPAKAKTINKYLG YVVK+S+GHI+DLP Sbjct: 1 MPKALVIVESPAKAKTINKYLGKQYVVKASLGHIKDLPKRD------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VD H +E YE++ GK+K++ EL+ A+ D IYLA D DREGEAI Sbjct: 42 ----------LAVDVEHGFEPRYEIIEGKKKLMGELRSAAKGVDQIYLAADPDREGEAIC 91 Query: 121 WHLREVIGGDD--ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 +HL+E + + RV+FNEITK A+ +AF KP ++N + V+AQQARR +DR+VGY Sbjct: 92 FHLQEELRSKKDGPAFFRVMFNEITKKAVEKAFEKPLQVNTNLVDAQQARRVLDRLVGYK 151 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +SPLLW K+ RGLSAGRVQ+VA+R++VEREREI+AF +E+W VD + L+ ++ Sbjct: 152 ISPLLWDKVRRGLSAGRVQTVALRVIVEREREIRAFQKKEYWTVDVDLLARTAPVLSTRL 211 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 ND+ N++ T + V+ L Y V + P APFITSTLQQ +S +L Sbjct: 212 IKANDETPELPNQQTTDSLVAQLSGVDYIVKSVATREKRRNPVAPFITSTLQQDSSRKLR 271 Query: 299 FGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 F VK+TMM+AQRLYE G ITYMRTDST S DA++ VR YI + +G +LP Sbjct: 272 FSVKRTMMLAQRLYEGIEIGRDGAVGLITYMRTDSTRTSDDAISDVRHYIGERYGAPFLP 331 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKY 408 +PN Y SK+ +Q+AHEAIRP+ + E ++ + D KLY+LIW +FVA QM PA + Sbjct: 332 PAPNVYKSKKEAQDAHEAIRPTSMAYSPEVVEQYLPEDEMKLYRLIWNRFVASQMMPALF 391 Query: 409 DSTTLTVGAG-----DFRLKARGRILRFDGWTKVMPALR---KGDEDRI---LPAVNKGD 457 D TT+ V A ++ +A G + +FDG+ KV + D++ + LP V +G+ Sbjct: 392 DQTTIDVSAKAANGVEYTFRATGSVPKFDGFLKVYQEGKDQTDEDDEELKHRLPLVTEGE 451 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L L + P QHFT+PP R++EA+LVK LE G+GRPSTYA+I+STIQ+R YV E RF Sbjct: 452 VLRLEAIRPEQHFTEPPPRYNEATLVKRLEADGVGRPSTYATILSTIQEREYVNKEAGRF 511 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 ++G +VTD L E+F ++ + +TA+ME LD++ + +W+A + F+ F + L Sbjct: 512 TPTELGMVVTDLLLESFDDIFDVKYTARMEEELDEIEEGKLDWRAAMSEFYGRFDKDLKH 571 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERC------- 630 AE+ + T + C CGR + I+ G F+ C+GY + Sbjct: 572 AEEHMTDIK---RMEKPTDLICEKCGRPLVIKWGKHGSFIACTGYPDFSSKSIESDLEKV 628 Query: 631 -------------KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK 677 K ++L + PK MD+ L + Sbjct: 629 QKDIEVRRQRALKKIELSLEKLRAKYPDRTITWGQDGEFLVIPSAPKIPKPMDAALKKLE 688 Query: 678 RKLHVCGN----NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN 733 +++ V + +++ ++KG+ + G + ++ R ++ Sbjct: 689 KEIAVKRSEDRGKIEARLEKLQARYPQMKGFYDLDLRDTAEGVALTVR--RKEEF----- 741 Query: 734 EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 C TR++ + + E CE VL+ G G F A + +P + TR Sbjct: 742 --CTYTRELTVDLPDLEGADLSEQGEEESCENCGRPMVLKKGRFGTFFACSEYPDCKTTR 799 Query: 794 AP 795 Sbjct: 800 QI 801 Score = 104 bits (260), Expect = 1e-20, Method: Composition-based stats. Identities = 39/229 (17%), Positives = 73/229 (31%), Gaps = 30/229 (13%) Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYA 623 +D +++ A K E+ G ++ P + T + + Sbjct: 680 MDAALKKLEKEI--AVKRSEDRGKIEARLEKLQARYPQMKGFYDLDLRDTAEGVALT--V 735 Query: 624 LPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVC 683 +E C T L +++ + E A+ + + C CG M C Sbjct: 736 RRKEEFCTYTRELT-----VDLPDLEGADLSEQGEEESCENCGRPMV-LKKGRFGTFFAC 789 Query: 684 GNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKI 742 P C G + +C +C + + +K GRFG++ AC+N CK ++ Sbjct: 790 SEYPDCKTTRQIGGTQK--KDVPLDEKCPQCDNNLVMKYGRFGEFTACSNYPTCKYVKQ- 846 Query: 743 LRNGEVAPPKEDPVPLPELPCEKS-DAYFVLRDGAAGV-FLAANTFPKS 789 + C + + + R G F N +P Sbjct: 847 --------------KTIGVKCPECSEGDIIERRSKKGKTFYGCNRYPDC 881 Score = 94.4 bits (233), Expect = 2e-17, Method: Composition-based stats. Identities = 37/199 (18%), Positives = 60/199 (30%), Gaps = 44/199 (22%) Query: 569 SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKE 628 +F + D + C CGR M ++ G F CS Y Sbjct: 739 EEFCTYTRELTVDLPDLEGADLSEQGEEESCENCGRPMVLKKGRFGTFFACSEYP----- 793 Query: 629 RCKTTINLVPENEVLNVLEGEDAETNALRAKR--------------------------RC 662 CKTT + + L+ + + + + +C Sbjct: 794 DCKTTRQIGGTQKKDVPLDEKCPQCDNNLVMKYGRFGEFTACSNYPTCKYVKQKTIGVKC 853 Query: 663 PKCGTA-MDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE-CEKCGSE-MH 719 P+C + + + C P C + P+ E C +CGS M Sbjct: 854 PECSEGDIIERRSKKGKTFYGCNRYPDC----------TFVAWGKPVAEKCPECGSPYMI 903 Query: 720 LKMGRFGKYMACTNEECKN 738 K + G + C N ECK+ Sbjct: 904 EKFLKSGAFWQCPNAECKH 922 Score = 50.5 bits (119), Expect = 3e-04, Method: Composition-based stats. Identities = 15/78 (19%), Positives = 28/78 (35%), Gaps = 2/78 (2%) Query: 737 KNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPK--SRETRA 794 + + + E + +L CEK V++ G G F+A +P S+ + Sbjct: 564 RFDKDLKHAEEHMTDIKRMEKPTDLICEKCGRPLVIKWGKHGSFIACTGYPDFSSKSIES 623 Query: 795 PLVEELYRFRDRLPEKLR 812 L + R L+ Sbjct: 624 DLEKVQKDIEVRRQRALK 641 >UniRef50_B8E2F6 DNA topoisomerase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8E2F6_DICTD Length = 696 Score = 654 bits (1686), Expect = 0.0, Method: Composition-based stats. Identities = 272/763 (35%), Positives = 403/763 (52%), Gaps = 85/763 (11%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+IVESPAKAKTI K LG ++ V +S GHIRDLP Sbjct: 5 KLIIVESPAKAKTIEKILGKEFKVLASYGHIRDLPE------------------------ 40 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +GVD +N++ Y +LP ++K++ +K L++KA+ +YLATD DREGEAIAWHL Sbjct: 41 -----KELGVDIENNFKPKYVLLPSRKKIIDTIKDLSKKAEKLYLATDPDREGEAIAWHL 95 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 E + +++R+ F+EIT AI +A P E+++DRV AQQARR +DR+VGY +SPLL Sbjct: 96 VEELKLPKEKFTRIEFHEITPRAILEAIKNPREIDLDRVEAQQARRILDRLVGYELSPLL 155 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 W+K+ +GLSAGRVQSVA+R + ERE EI+ F+PEE+W + + L ++ D Sbjct: 156 WEKVRKGLSAGRVQSVALRFICEREEEIEKFIPEEYWYIYGEFRDEE-KVLYGKLILYKD 214 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 + N+++ + +L Y + + K P PFITSTLQQ AS R GF V K Sbjct: 215 EEVNVKNEQEVNKIIRILNCLDYRIDKVVIKEEKRTPPPPFITSTLQQEASKRFGFPVGK 274 Query: 304 TMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQY 355 TM +AQ LYE G ITYMRTDST ++ +A YI FGK+Y+ + + Sbjct: 275 TMKIAQSLYEGVDIGNERIGLITYMRTDSTRIAPEAREEAVQYIESGFGKEYVGKEHKE- 333 Query: 356 ASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLT 414 K Q+AHEAIRP+ V E ++ + + K+Y+LIW +F+A QM A ++ + Sbjct: 334 KKKLGVQDAHEAIRPTSVFRDPEKIRKYLTDEQFKIYKLIWERFIASQMNHAIFEVVEIY 393 Query: 415 VGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAV----NKGDALTLVELTPAQHF 470 + GD+ ++G+ L+F G+ + + E++ + +G + L L P Q F Sbjct: 394 IKGGDYVFLSKGKKLKFAGFMSLYMEKEENGEEKDEVNIDYVPEEGKNVKLTTLIPRQFF 453 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP R++EA+LV+ LEK G+GRPSTYA+II T+++R YV V++R +G++V D L Sbjct: 454 TEPPPRYTEATLVRTLEKYGVGRPSTYATIIETLKERKYVEVKDRTLVPTTLGKVVNDFL 513 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 + F L++ FTA+ME LD++ + + + VL F+ F ++L+K K+ + + Sbjct: 514 TKQFPHLIDVKFTARMEEDLDKIESGKVKAIEVLKKFYPAFKEELEKVSKNIGKIQV--- 570 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 + T CP CG K+ IR G + CS Y CK T + E Sbjct: 571 -IEKTDEICPLCGSKLVIRENKNGKYYACSRYP-----ECKYTKPIYEE----------- 613 Query: 651 AETNALRAKRRCPKCGT-AMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV 709 A+ RCP CG + K+ C N P C Y+ Sbjct: 614 -------AQGRCPLCGGVVVKKKAKKTKKTFWGCINYPECSFA---------SPYEPLNE 657 Query: 710 ECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 +C +CGS M G + C+N++C R K Sbjct: 658 KCPQCGSTMLKGNG----FKKCSNKDCNYIVWTGRRKRWKKSK 696 Score = 59.3 bits (142), Expect = 6e-07, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 36/101 (35%), Gaps = 16/101 (15%) Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAP 750 ++ + +I+ + C CGS++ ++ + GKY AC+ ECK T+ I + Sbjct: 559 EKVSKNIGKIQVIEKTDEICPLCGSKLVIRENKNGKYYACSRYPECKYTKPIYEEAQGR- 617 Query: 751 PKEDPVPLPELPCEKSDAYFVLRDGAAGV--FLAANTFPKS 789 C V + F +P+ Sbjct: 618 ------------CPLCGGVVVKKKAKKTKKTFWGCINYPEC 646 Score = 55.1 bits (131), Expect = 1e-05, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 23/50 (46%), Gaps = 1/50 (2%) Query: 752 KEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELY 801 K + + C + V+R+ G + A + +P+ + T+ P+ EE Sbjct: 567 KIQVIEKTDEICPLCGSKLVIRENKNGKYYACSRYPECKYTK-PIYEEAQ 615 >UniRef50_B2KBN6 DNA topoisomerase n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KBN6_ELUMP Length = 765 Score = 652 bits (1683), Expect = 0.0, Method: Composition-based stats. Identities = 295/794 (37%), Positives = 429/794 (54%), Gaps = 92/794 (11%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK LVIVESP K KTI+K LG+DYVVKSS GH+RDLP+ Sbjct: 17 GKNLVIVESPTKQKTISKILGADYVVKSSFGHVRDLPS---------------------- 54 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +GVD + ++ Y + +K+VSEL++LA+ ++++YLATD DREGEAIAW Sbjct: 55 -------KEIGVDEKNGFKPKYVPVEKAKKMVSELEKLAKGSEYVYLATDPDREGEAIAW 107 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL E++ + R+ F+EIT A++ +F+ +N D V+AQQARR +DR+VGY +SP Sbjct: 108 HLVELLKIPVEKIRRIFFHEITPAAVKASFDHARNINKDLVDAQQARRVLDRLVGYKLSP 167 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFW----EVDASTTTPSGEALALQ 237 LLWKKI GLSAGRVQSVAVRL+ ER +EI+ F EE++ E++ TP A L+ Sbjct: 168 LLWKKITGGLSAGRVQSVAVRLLAERAKEIENFREEEYYSLTSELEKQGETPKFNARMLK 227 Query: 238 VTHQNDKPFR---------------PVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 +N + E SLL + +V + E K K Sbjct: 228 WRGKNTEIITTYHLFAEDYKVKTTVFKKPEDLAPVNSLLRQGPLTVSKIEKKEVKQKAKP 287 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNM 334 PFITS+LQQ A ++GF +KTMM AQ LYE G ITYMRTDS N+S+D + Sbjct: 288 PFITSSLQQEAYNKIGFPSQKTMMTAQSLYEGVEIAGEVVGLITYMRTDSFNVSKDLQSQ 347 Query: 335 VRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQ 392 + +I+ +G ++P +PN + SK + +QEAHE+I P+DV S+KD + AD KLY+ Sbjct: 348 TKKFIAGKYGDDFVPPTPNFFKSKVKGAQEAHESIHPTDVYKTPASIKDYLSADQYKLYE 407 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFR---LKARGRILRFDGWTKVMPALRKGDEDR- 448 LIW +F+A QM A +++ ++ + AG L+A GR ++F G+ V +ED Sbjct: 408 LIWLRFIASQMADAVFNTVSVDITAGKAEECVLRATGRTVKFPGFLSVYKEDDSEEEDEG 467 Query: 449 --ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506 +LP + +GD L L+++ H T PP ++EASL+K LEK GIGRPSTYA I TI D Sbjct: 468 SALLPNLTEGDDLNLIDIVTKSHKTAPPPNYNEASLIKTLEKHGIGRPSTYAPTIKTILD 527 Query: 507 RGYVRVENR--RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 R Y+ + + + +G VTD+L++ F+++M+ +TA +E LD +A + +W V+ Sbjct: 528 RKYIIRQPKTNKLIVTDLGVTVTDQLKDFFKDIMDLSYTAGIEEKLDDIAEGDNDWVKVI 587 Query: 565 DHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYAL 624 F+ F + L A+KD + +P+ CP CG M IR + G +L CS Y Sbjct: 588 GDFYEGFKKDLATADKDMQRAAPKPSDE-----KCPLCGSPMVIRRSRFGEYLACSTYP- 641 Query: 625 PPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCG 684 CK INL E L E+ +C KCG+ M + K C Sbjct: 642 ----ECKGKINLTSSGEKLAPEVTEE----------KCEKCGSPMVIR-SGRRGKFMACS 686 Query: 685 NNPTCDGY---EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTR 740 P C + + G ++CEKCG M L+ + G+++ C+ +CK Sbjct: 687 AFPKCKNTFSIDASGNKVASSGPIETKIKCEKCGKPMLLRASKRGEFLGCSGYPKCKTIV 746 Query: 741 KILRNGEVAPPKED 754 + E+A K++ Sbjct: 747 SVSPE-EIAKIKKE 759 >UniRef50_D1B572 DNA topoisomerase n=7 Tax=Campylobacterales RepID=D1B572_SULD5 Length = 694 Score = 649 bits (1673), Expect = 0.0, Method: Composition-based stats. Identities = 290/749 (38%), Positives = 405/749 (54%), Gaps = 71/749 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+IVESP KAKTI +LG +Y V +S GHIRDLP S K Sbjct: 6 KNLIIVESPTKAKTIKNFLGKNYTVVASKGHIRDLPKSSFGIKIDN-------------- 51 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + Y V VV E+K+LA++AD +Y+ATD DREGEAI +H Sbjct: 52 --------------QTFIPEYRVPKDHASVVKEIKELAKEADQVYIATDEDREGEAIGFH 97 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 + IG D R+VF+EITKNAI A P L+ +NAQQARR +DR+VGY +SPL Sbjct: 98 IATAIGKDPKSLPRIVFHEITKNAITHALENPRILDESSINAQQARRLLDRIVGYKLSPL 157 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 L KI +GLSAGRVQS +++VV+RE+EI+AF EEFW +DA + EA ++ + Sbjct: 158 LSSKIQKGLSAGRVQSSTLKIVVDREKEIRAFKEEEFWSIDALF-NKTIEASLVEFEGEK 216 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 + N+E+ A L K + V E K S P F+TSTLQQ+AS+ LG+ K Sbjct: 217 IEKMSIGNQERAYAIKEKLLKEAFHVALLEKKERESSPSPAFMTSTLQQSASSALGYSPK 276 Query: 303 KTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 KTMM+AQ LYE G ITYMRTDS N+S++A+ R I +GK YLPE Sbjct: 277 KTMMLAQTLYEGVKTHQGVQGVITYMRTDSLNVSKEAIEAAREQILSQYGKTYLPEKARF 336 Query: 355 YASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 YA+K + +QEAHEAIRP+ + + D KLY LI+ +F+A QM A+++S T Sbjct: 337 YANKSKGAQEAHEAIRPTILEFTPAIASAYLAPDELKLYALIYNRFLASQMNNARFESQT 396 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 L + + KA GR L FDG+ KV D+D++LP + +TL +L QHFT+ Sbjct: 397 LIFESQSGKFKASGRKLLFDGFYKVYG---DNDKDKLLPDLALKQEVTLSKLDANQHFTE 453 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PP+R+SEASL+K+LE GIGRPSTYA IS + R Y+ +E ++ ++ VT+ LE+ Sbjct: 454 PPSRYSEASLIKKLESLGIGRPSTYAPTISVLSARDYINIEKKQIVPTEVAFQVTELLEQ 513 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 +F ++++ FT+ ME LD +A + +W+A+L +F+ F Q+ K + + + + + Sbjct: 514 HFPQIVDSSFTSTMEERLDLIAEDKEDWQAILWNFYEPFDAQVAKGKTEIQSQKV----I 569 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 V T CP CG+++ R G F+ CS Y CK T NL V E E Sbjct: 570 VFTGEMCPECGKELVRRKGRFGEFIACSTYPT-----CKYTQNL------KKVSESAPKE 618 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 L CP+CG + + K CGN P C I Y+ +C Sbjct: 619 KVTLSV--PCPECGGEIIER-SSRRGKFFGCGNYPKCKF---------ISNYEPTDKKCP 666 Query: 713 KCGSEMHLKMGRFGKYMACTNEECKNTRK 741 +CG M + R + C +CK+ + Sbjct: 667 ECGYIMAKRELRKKEIYECI--KCKHKEE 693 Score = 98.6 bits (244), Expect = 8e-19, Method: Composition-based stats. Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 4/83 (4%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C +CG E+ + GRFG+++AC+ CK T+ + + E AP ++ + +PC + Sbjct: 576 CPECGKELVRRKGRFGEFIACSTYPTCKYTQNLKKVSESAPKEKVTL---SVPCPECGGE 632 Query: 770 FVLRDGAAGVFLAANTFPKSRET 792 + R G F +PK + Sbjct: 633 IIERSSRRGKFFGCGNYPKCKFI 655 Score = 60.9 bits (146), Expect = 2e-07, Method: Composition-based stats. Identities = 11/49 (22%), Positives = 20/49 (40%) Query: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 G+ + + C + V R G G F+A +T+P + T+ Sbjct: 558 KGKTEIQSQKVIVFTGEMCPECGKELVRRKGRFGEFIACSTYPTCKYTQ 606 >UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus RepID=Q5SM69_THET8 Length = 830 Score = 648 bits (1671), Expect = 0.0, Method: Composition-based stats. Identities = 286/833 (34%), Positives = 400/833 (48%), Gaps = 120/833 (14%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 + LV+VESPAKA++I K LG Y V++S+GH+ DLP Sbjct: 15 AETLVVVESPAKARSIQKMLGPGYEVRASLGHVVDLPERS-------------------- 54 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +GVD ++ YEV K+ VV ELK+ A + + +ATD DREGEAI W Sbjct: 55 ---------LGVDVERDFAPTYEVKKDKKPVVEELKRAA-EGKRLLIATDPDREGEAIGW 104 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ ++G D RV F+EIT +RQA P ++ + V+AQQARR +DR++GY +SP Sbjct: 105 HVARLLGRDPKEPLRVEFHEITPRVVRQAVEAPRPIDQNLVDAQQARRVLDRLLGYNLSP 164 Query: 182 LLWKKI-ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 LL + R LSAGRVQSVA+RLVVERE I+AF PEE+W + GEA + H Sbjct: 165 LLSLEFRKRALSAGRVQSVALRLVVEREEAIEAFRPEEYWVLRGVFAVEGGEAPLVATLH 224 Query: 241 QNDKPFRPVNKEQTQAAVSL------------LEKARYSVLEREDKPTTSKPGAPFITST 288 + + + + + + L L K Y V + E + P PF TST Sbjct: 225 EVEGKRLWTGQGEKEGRLHLASEAEAHALAEALRKGSYRVAQVEVRERRKAPPPPFTTST 284 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYIS 340 LQQAAS+RLG+ +TM +AQRLYE G ITYMRTDS ++ +AV R I Sbjct: 285 LQQAASSRLGYTAARTMRIAQRLYEGVDLPEGTVGLITYMRTDSVRVAPEAVAAAREVIG 344 Query: 341 DNFGKKYLPESPNQYAS-KENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQF 398 FG +YLPE+P Y + +E Q+AHEAIRP+D ES++ + + +LY+LIWR+F Sbjct: 345 KAFGPEYLPEAPRAYKNRREGVQDAHEAIRPTDPKRTPESVRPYLSEEEYRLYELIWRRF 404 Query: 399 VACQMTPAKYDSTTLTVGA--GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKG 456 +A QM A Y+ T +T+ G + +A G +LRF+G+ + + +E+ +PAV +G Sbjct: 405 LASQMRDALYEQTAVTLADLEGRYAFRASGSVLRFEGYLRAWGRDAEEEEEPPVPAVPEG 464 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 L E+ + FT+PP R+++ASLVK +E+ GIGRPSTYA + T++ RGYV + R Sbjct: 465 VPARLEEVLEERRFTEPPPRYTDASLVKTMEELGIGRPSTYAPTLETLEKRGYVARKGRT 524 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 + +G VT L E F +++ Y+FTA+ME LD+V W V+ F+ F +L Sbjct: 525 LFPTPLGRQVTAYLRERFPQVVAYEFTARMEERLDEVEEGRVPWPKVVWEFYEPFLGELA 584 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 + K CP CGR + ++ + G FLGC+GY C T L Sbjct: 585 QVPKK----------------TCPRCGRPLELKVSRYGQFLGCTGYP-----ECTYTEPL 623 Query: 637 VPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEE 696 A CPKCG + C P CD + Sbjct: 624 ERRE--------------AEPIGEACPKCGRPLLRKE-GRYGTFIACSGYPECDYTRDD- 667 Query: 697 GEFRIKGYDGPIVECEKCGSEMHLKMGRFG-KYMACTNEECKNTRKILRNGEVAPPKEDP 755 C KCG + K R G Y C N C Sbjct: 668 -------GTPTGHTCPKCGGRVLEKRSRKGRPYYKCENNACDFL--------------SF 706 Query: 756 VPLPELPCEKSDAYFVLRDGAAGVFLAANT--FPKSRETRAPLVEELYRFRDR 806 PL E C V G P+ + P +E + R R Sbjct: 707 YPLLEEACPACGWPLV----KKGEKALCLNPACPEHEPSLLPAPKEAKKGRSR 755 Score = 55.1 bits (131), Expect = 1e-05, Method: Composition-based stats. Identities = 11/60 (18%), Positives = 20/60 (33%) Query: 750 PPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPE 809 P + +P+ C + L+ G FL +P+ T E + P+ Sbjct: 578 PFLGELAQVPKKTCPRCGRPLELKVSRYGQFLGCTGYPECTYTEPLERREAEPIGEACPK 637 >UniRef50_D1Y390 DNA topoisomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y390_9BACT Length = 767 Score = 645 bits (1663), Expect = 0.0, Method: Composition-based stats. Identities = 283/758 (37%), Positives = 394/758 (51%), Gaps = 95/758 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK LV+VESP KAKT+ K LGS YVVK+SVGHI DLP S Sbjct: 71 GKTLVVVESPTKAKTLTKILGSGYVVKASVGHIVDLPKS--------------------- 109 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 R+ +D ++++ Y ++ GK V EL+ A A I LA D DREGEAIAW Sbjct: 110 --------RLAIDIENDFKPEYILVKGKAPVKKELQAAAATAQKILLAADPDREGEAIAW 161 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ E++G D RV F+EIT +A+R A +P +++DRV+AQQARR +DR+VGY +SP Sbjct: 162 HVAELLGVDPKENCRVRFHEITADAVRNAVKEPAPIDMDRVDAQQARRVLDRLVGYTLSP 221 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLWKKI RGLSAGRVQSVA+ ++ ERE+EI+ FVP+++W V T G A L V + Sbjct: 222 LLWKKIRRGLSAGRVQSVALAILCEREQEIENFVPQDYWNVFVDATADDGRAYRLHVERE 281 Query: 242 NDKPFRPVNK-------EQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 N + K + + L++ V K K APF TST+QQ A+ Sbjct: 282 NGRSLLSDGKTLAIDTLAKVRDIEKTLKEKPLIVASFTAKKNARKQPAPFKTSTMQQIAA 341 Query: 295 TRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 +RLGF ++TM +AQ L+E G +TYMRTDS ++ +A++ R I +GK Sbjct: 342 SRLGFSPRRTMGIAQSLFEGVAIPGHGTVGLVTYMRTDSLRMAPEALSQARKVIEGRWGK 401 Query: 346 KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMT 404 KYLP Y + N+Q+AHEAIRP+D + ES+++ + A+ +LY +IWR+ VA QM Sbjct: 402 KYLPAKAVVYQAGANAQDAHEAIRPTDFALTPESIRESLTAEQYRLYDMIWRRSVASQMA 461 Query: 405 PAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 464 PA DS TL G + L+A+G + FDGW V K D ++ +G+ L + + Sbjct: 462 PAVVDSATLDCECGKYGLRAQGASVGFDGWGAVWDLDVK---DAMIQKAREGELLNIRNV 518 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMG 523 + TKPPARF+E++L+K LE GIGRPSTYA+I+ T+ DR YV E R+ ++G Sbjct: 519 QSEKEQTKPPARFTESTLIKTLEDDGIGRPSTYATIVETLYDRSYVAREEGRKLKPSELG 578 Query: 524 EIVTDRLEENF-----RELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 V L E+F +++ FT+ ME+SLDQV + + W ++ F+ FT + +A Sbjct: 579 RSVNKFLLEHFDGKSTSPIVDVGFTSSMESSLDQVESGKKNWVELIGQFWKPFTDAIAEA 638 Query: 579 EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVP 638 EK P P LT CP CGR + + G F+GCSG+ C + Sbjct: 639 EKAPVVPPPPPE---LTGETCPQCGRPLVKKQGRFGDFIGCSGFP-----ECHYIKPVQK 690 Query: 639 ENEVLNVLEGEDAETNALRAKRRCPKCGTA----MDSYLIDPKRKLHVCGNNPTCDGYEI 694 E V CPKCG + R + C P CD Sbjct: 691 EIGV------------------PCPKCGNEHGGQVVQRKSKKGRTFYGCSRYPDCDY--- 729 Query: 695 EEGEFRIKGYDGPIVECEKCGSEMH-LKMGRFGKYMAC 731 + +C CG M + R C Sbjct: 730 ------VSWNKPAPEKCPLCGGLMEYVGRSRTPVCTKC 761 Score = 82.8 bits (203), Expect = 5e-14, Method: Composition-based stats. Identities = 26/133 (19%), Positives = 42/133 (31%), Gaps = 23/133 (17%) Query: 667 TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY----DGPIVECEKCGSEMHLKM 722 +++D K + + G I E E + C +CG + K Sbjct: 608 SSLDQVESGKKNWVELIGQFWKPFTDAIAEAEKAPVVPPPPPELTGETCPQCGRPLVKKQ 667 Query: 723 GRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKS----DAYFVLRDGAA 777 GRFG ++ C+ EC + + + V PC K V R Sbjct: 668 GRFGDFIGCSGFPECHYIKPVQKEIGV-------------PCPKCGNEHGGQVVQRKSKK 714 Query: 778 GV-FLAANTFPKS 789 G F + +P Sbjct: 715 GRTFYGCSRYPDC 727 Score = 60.9 bits (146), Expect = 2e-07, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 23/63 (36%), Gaps = 1/63 (1%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 T I + P L C + V + G G F+ + FP+ + P+ Sbjct: 631 FTDAIAEAEKAPVVPPPPPELTGETCPQCGRPLVKKQGRFGDFIGCSGFPECHYIK-PVQ 689 Query: 798 EEL 800 +E+ Sbjct: 690 KEI 692 >UniRef50_A8RBU5 DNA topoisomerase n=9 Tax=Bacteria RepID=A8RBU5_9FIRM Length = 718 Score = 644 bits (1660), Expect = 0.0, Method: Composition-based stats. Identities = 287/773 (37%), Positives = 415/773 (53%), Gaps = 81/773 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESP+K+KTI KYLG+DY+V SS GHIRDL T+G Sbjct: 2 KNLVIVESPSKSKTIEKYLGNDYMVVSSKGHIRDLATTGKGG------------------ 43 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +G+D H++E Y++ K VV ELK LA+K+DHIYLA+D DREGEAIAWH Sbjct: 44 --------LGIDVEHDFEPTYKISADKRSVVKELKDLAKKSDHIYLASDPDREGEAIAWH 95 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L +V+G D +R+VFNEITK A+ +A P ++I V +Q+ RR +DR++G+ +S L Sbjct: 96 LAQVLGLDVNDENRIVFNEITKGAVTEALKHPRTIDIPMVKSQETRRMLDRIIGFKLSKL 155 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 L KI + SAGRVQSVA+RL+VERE+EI+AF EE+W + A S + + Sbjct: 156 LQSKI-KSKSAGRVQSVALRLIVEREQEIRAFKSEEYWTLAALVDKDSKK-FNANLIRIG 213 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K +++ A +S + V E K +P PFITSTLQQ AST+LGFG K Sbjct: 214 GKKAELKTQQEVDAIISRC--HEFKVSSIEKKVRKKEPRMPFITSTLQQEASTKLGFGAK 271 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 KTM +AQ+LYE G I+YMRTDST LS+ V YI D +GK Y + Sbjct: 272 KTMQIAQKLYEGIALQGGNAEGLISYMRTDSTRLSEQFVRDAEQYIEDTYGKAYCGRA-- 329 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 + + EN+Q+AHEAIRP+++ ES+K+ + D KLY+LI+ + +A M P+K + Sbjct: 330 RQKNSENAQDAHEAIRPTNIQHTPESIKNYLTNDQYKLYKLIYARTLASLMAPSKSNVVN 389 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 + + D A G IL FDG+ K+ +D +LP + +G+ L V L QHFT+ Sbjct: 390 AIIVSEDCEFSANGSILAFDGYLKIYHDYE-TVKDEMLPVLEEGEKLEKVRLEGKQHFTE 448 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN-------RRFYAEKMGEI 525 PP R+SEA L+K+LE++GIGRPSTYA II T+Q RGYV +E + F+ + GE+ Sbjct: 449 PPLRYSEARLIKDLEEKGIGRPSTYAIIIDTLQARGYVSLEKSSEGSKTKVFFPSEQGEL 508 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 +L+E F L+N +TA+ME LD++A + + L F++ F L+ A + E+ Sbjct: 509 TDAKLKEFFSNLINVTYTAEMEAKLDEIAANTLDNIEELKRFYAKFEPLLENAYEHMEK- 567 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 ++ T CP CG ++ R G F+ C + C+ T + E Sbjct: 568 ----KELERTGELCPECGSELVYRVGRYGKFISCINFPS-----CRYTKSEEEEENA--- 615 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYD 705 + CP CG+ M C N PTC + + + Sbjct: 616 ------------SDEVCPHCGSKMVM-KKGRYGSFLACSNYPTCKYIKNNKPKEEPV--- 659 Query: 706 GPIVECEKCGSEMHLKMGRFG-KYMACTN-EECKNTRKILRNGEVAPPKEDPV 756 C +CG + + RFG ++ C+N +C+ +K + + ++ V Sbjct: 660 PTGENCPECGHPLVKRKSRFGTTFVGCSNYPKCRYIKKEPKKAKEKKSDKEAV 712 Score = 94.8 bits (234), Expect = 1e-17, Method: Composition-based stats. Identities = 23/99 (23%), Positives = 44/99 (44%), Gaps = 11/99 (11%) Query: 702 KGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPE 760 K + C +CGSE+ ++GR+GK+++C N C+ T+ + + Sbjct: 568 KELERTGELCPECGSELVYRVGRYGKFISCINFPSCRYTKSEEEEENAS----------D 617 Query: 761 LPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEE 799 C + V++ G G FLA + +P + + +E Sbjct: 618 EVCPHCGSKMVMKKGRYGSFLACSNYPTCKYIKNNKPKE 656 Score = 55.5 bits (132), Expect = 8e-06, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 23/54 (42%), Gaps = 1/54 (1%) Query: 741 KILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 +L N K++ + C + + V R G G F++ FP R T++ Sbjct: 556 PLLENAYEHMEKKE-LERTGELCPECGSELVYRVGRYGKFISCINFPSCRYTKS 608 Score = 43.5 bits (101), Expect = 0.038, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 27/77 (35%), Gaps = 6/77 (7%) Query: 581 DPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV-FLGCSGYALPPKERCKTTINLVPE 639 + + V T +CP CG + R + G F+GCS Y +C+ + Sbjct: 647 KYIKNNKPKEEPVPTGENCPECGHPLVKRKSRFGTTFVGCSNYP-----KCRYIKKEPKK 701 Query: 640 NEVLNVLEGEDAETNAL 656 + + E N Sbjct: 702 AKEKKSDKEAVGEKNEE 718 >UniRef50_C6WSV7 DNA topoisomerase n=4 Tax=Proteobacteria RepID=C6WSV7_METML Length = 864 Score = 641 bits (1653), Expect = 0.0, Method: Composition-based stats. Identities = 309/846 (36%), Positives = 447/846 (52%), Gaps = 89/846 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP+KAKT+ KYLGSD+ V +S GH+RDL Sbjct: 1 MSK-LLIVESPSKAKTLKKYLGSDFEVLASYGHVRDL----------------------- 36 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VD + + Y+++ K V + + + AD IYLATD DREGEAI+ Sbjct: 37 ------IPKNGAVDTENQFAMKYDIIERNSKHVDAIAKAVKNADSIYLATDPDREGEAIS 90 Query: 121 WHLREVIGGDDARYS----RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WH+ E++ + RVVF+EITK A+ A +P ++++ VNAQQARR +D +VG Sbjct: 91 WHIAEILKSKKLLKNKLMKRVVFHEITKGAVEHAIAEPRDISMPMVNAQQARRALDYLVG 150 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV--DASTTTPSGEAL 234 + +SPLLWKKI RGLSAGRVQS A+RL+VERE EI+AF +E+W + DA +A Sbjct: 151 FNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWSIHLDALKHQHGFKAK 210 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLL---EKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 +Q+ +Q + F +N +Q V L + +V E K + P APF TSTLQQ Sbjct: 211 LVQLNNQKVEQFTVINHDQQSDIVGKLLLASAGKTTVSRVEKKQRSRSPAAPFTTSTLQQ 270 Query: 292 AASTRLGFGVKKTMMMAQRLYEAG--------YITYMRTDSTNLSQDAVNMVRGYISDNF 343 A +LGF + M +AQ+LYE ITYMRTDS +L+ +AV +R Y+ NF Sbjct: 271 EAVRKLGFTTSRAMRVAQQLYEGVDVGGGTVGLITYMRTDSFSLATEAVMQIRDYVKKNF 330 Query: 344 GKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 +YLP+SP Y +K +++QEAHEAIRP+D++ S++ + + KLY++IW++ +AC Sbjct: 331 DTEYLPKSPVMYKTKSKSAQEAHEAIRPTDISRTPTSVRQYLNDEQFKLYEMIWKRALAC 390 Query: 402 QMTPAKYDSTTLTVGAGD--FRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKG 456 QM PAK+D+ ++ + G +A G+ L F G+ V + + + LP + G Sbjct: 391 QMAPAKFDAVSVDLSVGSDANLFRATGQTLVFPGFIAVYMEGSDDEEEEAESKLPNLETG 450 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 + LT+ ++ QHFT+PP R+SEASLVK LE+ GIGRPSTYASIIST+QDR YV ++ +R Sbjct: 451 EILTVEKIYGEQHFTEPPPRYSEASLVKVLEEYGIGRPSTYASIISTLQDREYVLLDKKR 510 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 F +G +V L E+F + ++YDFTA +EN+LD VA E +W ++D F+ DF QQ+ Sbjct: 511 FTPTDVGRVVNKFLTEHFTKYVDYDFTANLENALDSVAEGERDWVPLMDEFWQDFNQQI- 569 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 + D E G L CP CG+ + + + G F+GC+GY PK K +I+ Sbjct: 570 HNKADVERPGNE-----LIDEACPKCGKPLQKQLSRFGSFIGCTGYNDTPKCDYKRSIDG 624 Query: 637 VPENEVLNVLEGEDAETNALRAKRRCP-----KCGTAMDSYLIDPKRKLHVCGNNPTCDG 691 V G DA T+ P + G A++ PKR V Sbjct: 625 TANAGTDPVSIGVDAATSKEIYLMNGPYGPYLQVGMAVEGEKKKPKR---VSIPKEIALA 681 Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPP 751 E + + + ++ +GRFG Y+ N + K + I +N V Sbjct: 682 DVNLETANMLLSLPRDLGLHPETNKKIIANIGRFGPYI---NHDAKF-KSIPKNLSVFSI 737 Query: 752 KED------------PVPLPELPC-EKSDAYFVLRDGAAGVFLA----ANTFPKSRETRA 794 D P PL L D + G G ++ T PKS E + Sbjct: 738 DLDGAVALLAQAHTGPAPLCSLGSHPTEDGQIEVFAGRYGPYVQHGKLRATLPKSIEPES 797 Query: 795 PLVEEL 800 +EE Sbjct: 798 LTMEEA 803 >UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria RepID=B6RA74_9RHOB Length = 931 Score = 640 bits (1651), Expect = 0.0, Method: Composition-based stats. Identities = 269/784 (34%), Positives = 405/784 (51%), Gaps = 95/784 (12%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 +VIVESPAKAKTINKYLG DY V +S GH+RDLP + Sbjct: 2 NVVIVESPAKAKTINKYLGKDYTVLASYGHVRDLPPKDGS-------------------- 41 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 V P ++ + V +K +SE+ ++AD + LATD DREGEAI+WH+ Sbjct: 42 ---------VLPDDDFAMSWSVDSKSQKRLSEIASAVKEADRLILATDPDREGEAISWHV 92 Query: 124 REVIGGDDAR----YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 EV+ RVVFN ITK++I +A P EL+ V+A ARR +D +VG+ + Sbjct: 93 LEVLKKKRVLKDKKIERVVFNAITKSSILEAMKNPRELDEPLVDAYLARRALDYLVGFTL 152 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP+LW+K+ SAGRVQSVA+RLV +RE EI+ F +E+W + A+ TP + ++T Sbjct: 153 SPVLWRKLPGARSAGRVQSVALRLVCQRENEIETFQSQEYWSILANLNTPENAPVQARLT 212 Query: 240 HQNDKP---FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 + + N+++ +L+ A + V E KP P APF TSTLQQ AS + Sbjct: 213 GFDGQKITRLDIKNEQEATTIKQMLDGASFQVSNVESKPQRRNPYAPFTTSTLQQEASRK 272 Query: 297 LGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LGF +TM +AQ+LYE G ITYMRTD ++Q+A+ RG I+ +G +Y+ Sbjct: 273 LGFAAARTMQVAQKLYEGANIGGETTGLITYMRTDGVQIAQEAITSARGVIASRYGDEYV 332 Query: 349 PESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPA 406 PE P Y+SK +N+QEAHEAIRP+D+ + ++ D +LY+LIW++ +A QM A Sbjct: 333 PEKPRMYSSKAKNAQEAHEAIRPTDLTRHPRDMAKFLDEDGARLYELIWKRTIASQMESA 392 Query: 407 KYDSTTLTVGA----GDFRLKARGRILRFDGWTKVMPALRKGDE---DRILPAVNKGDAL 459 + TT+ + A L+A G ++RFDG+ + + +E + LP + +GD+L Sbjct: 393 VLERTTVDIDAVNGAKKAALRASGSVVRFDGFLTLYQEGKDDEEDEESKRLPPMTRGDSL 452 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 + QHFT+PP RF+EA+LVK++E+ GIGRPSTYA+ + T++DRGYV ++ +R Sbjct: 453 GRKGIEANQHFTEPPPRFTEATLVKKMEELGIGRPSTYAATLQTLRDRGYVELDKKRLIP 512 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 + G +VT LE+ F + YDFTA +E+ LD+++ + EWKAVL F++ F + D+ Sbjct: 513 QDKGRLVTAFLEDFFNRYVEYDFTASLEDQLDKISAGDLEWKAVLRDFWNPFHEICDEVI 572 Query: 580 KDPEEGGMRPNQMVLTSI------------DCPTCG-RKMGIRTASTGVFLGCSGYALPP 626 K + L + CP C ++ ++ + G F+GCS Y Sbjct: 573 KRSNTEVLDALNETLKAHVFPDKEDGSDPRKCPKCDTGRLSLKVSRFGAFVGCSNYNKDK 632 Query: 627 KER---------CKTTINLVP----------ENEVLNVLEGEDAETNALRAKRRCPKCGT 667 K+ C T L + + ++ E +LR R P Sbjct: 633 KDGKEPNENPPHCDYTRQLTSGGDSDAGAAADGPQVLGIDPETGLEVSLRTGRFGPY--- 689 Query: 668 AMDSYLIDPKRKLHVCGNNP--TCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRF 725 PKR + P E ++ + + G + +GRF Sbjct: 690 VQLGEEAKPKR-----SSLPRGWSVADLDLEKALQLLSLPREVGTHPEDGKTISAGLGRF 744 Query: 726 GKYM 729 G ++ Sbjct: 745 GPFV 748 Score = 50.1 bits (118), Expect = 4e-04, Method: Composition-based stats. Identities = 19/87 (21%), Positives = 31/87 (35%), Gaps = 16/87 (18%) Query: 710 ECEKCG-SEMHLKMGRFGKYMACTN---------------EECKNTRKILRNGEVAPPKE 753 +C KC + LK+ RFG ++ C+N C TR++ G+ Sbjct: 603 KCPKCDTGRLSLKVSRFGAFVGCSNYNKDKKDGKEPNENPPHCDYTRQLTSGGDSDAGAA 662 Query: 754 DPVPLPELPCEKSDAYFVLRDGAAGVF 780 P ++ LR G G + Sbjct: 663 ADGPQVLGIDPETGLEVSLRTGRFGPY 689 >UniRef50_A8SJ74 DNA topoisomerase n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SJ74_9FIRM Length = 703 Score = 639 bits (1648), Expect = 0.0, Method: Composition-based stats. Identities = 273/760 (35%), Positives = 411/760 (54%), Gaps = 78/760 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESP KAKT++K LGS+Y V +SVGHIRDLP S Sbjct: 9 KNLVIVESPTKAKTVSKMLGSNYKVVASVGHIRDLPKS---------------------- 46 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +MG+D +N+E Y + GK + ELK+L + +++IYLATD DREGEAI+WH Sbjct: 47 -------KMGIDIENNFEPEYINVRGKASKIKELKELYKNSENIYLATDPDREGEAISWH 99 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 + ++G D +R+ F+EITK +I+++ +++++ VN+QQARR +DR+VGY +SP+ Sbjct: 100 IAYLLGLDINDNNRIEFHEITKKSIKESIKNSRKIDMNLVNSQQARRVLDRLVGYKLSPI 159 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LWKKI GLSAGRVQS ++++ ER+ EI FVPEEFW+++ + E +L Sbjct: 160 LWKKIKSGLSAGRVQSATLKIICERQEEIDNFVPEEFWKIEGIHNVQNIEFKSLYYGEYE 219 Query: 243 DKPF---RPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 +K N+++ V +K + V + + KP PF TSTLQQ A +LGF Sbjct: 220 NKKIVKKEIKNEKEALKVVEKTDKDNFIVEDVKKVKKERKPQPPFTTSTLQQEAGRKLGF 279 Query: 300 GVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 TM +AQ+LYE G I+YMRTDST +S + V YI++N+GK Y + Sbjct: 280 SSSMTMSIAQQLYEGINVGKEGSVGLISYMRTDSTRISSEIVAEAIEYITENYGKNYASK 339 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 K+NSQ+AHE +RPS + E +K + ++ KLY+LIW + VA QM Y+ Sbjct: 340 GNEYNLKKKNSQDAHEGVRPSSIFRSPEKIKSYLTSNQYKLYKLIWERTVASQMKAESYE 399 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 ST + + + + K GR FDG++K+ + DE LP + D + ++ +QH Sbjct: 400 STQIVLNSNNCIYKLNGRYTLFDGFSKIYTSSDIKDE--PLPKLEVKDVINAEKIEKSQH 457 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FTKP A F+EASLVK+LE+ GIGRPSTYASII+++ R Y+ +EN++ +G+ V Sbjct: 458 FTKPVANFTEASLVKKLEENGIGRPSTYASIINSLTSRFYILIENKKIIPTDLGKNVNKF 517 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 L NF ++N FT +ME LD++A ++ +WK V+ F++ F L ++E D E+ ++ Sbjct: 518 LVSNFETIINEKFTMEMEEKLDEIAENKKDWKKVISDFYAVFETFLKRSEGDSEDYKIKD 577 Query: 590 NQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE 649 + CP CG+ + I+ G F+GCSG+ C V + V Sbjct: 578 E---VLDEKCPQCGKNLVIKKTKFGRFIGCSGFP-----DCNYIKKEVKDTGV------- 622 Query: 650 DAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV 709 +CPKCG + + ++ + C N P CD ++ Sbjct: 623 -----------KCPKCGGRIIEKISKKRKVFYGCENYPECDYAIWDK--------PIADK 663 Query: 710 ECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVA 749 +CEKCG + RF + C++E C + + Sbjct: 664 KCEKCGKFLVEVKNRFKHALKCSDENCDFEIDLKKKKNEK 703 Score = 76.3 bits (186), Expect = 5e-12, Method: Composition-based stats. Identities = 15/99 (15%), Positives = 36/99 (36%), Gaps = 15/99 (15%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKED 754 + E + +C +CG + +K +FG+++ C+ +C +K +++ Sbjct: 569 DSEDYKIKDEVLDEKCPQCGKNLVIKKTKFGRFIGCSGFPDCNYIKKEVKD--------- 619 Query: 755 PVPLPELPCEKSDAYFVLRDGA-AGVFLAANTFPKSRET 792 + C K + + VF +P+ Sbjct: 620 ----TGVKCPKCGGRIIEKISKKRKVFYGCENYPECDYA 654 Score = 52.0 bits (123), Expect = 1e-04, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 14/37 (37%) Query: 757 PLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 + + C + V++ G F+ + FP + Sbjct: 578 EVLDEKCPQCGKNLVIKKTKFGRFIGCSGFPDCNYIK 614 >UniRef50_B0VJB5 DNA topoisomerase n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VJB5_9BACT Length = 739 Score = 638 bits (1646), Expect = 0.0, Method: Composition-based stats. Identities = 278/807 (34%), Positives = 404/807 (50%), Gaps = 89/807 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKA TI+K+L + + VK+S+GHIRDLP Sbjct: 1 MSKGLIIVESPAKAGTISKFLKNQFSVKASMGHIRDLPK--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GV+ ++ Y + K KV++ELK+ AD +YLA+D DREGEAIA Sbjct: 40 --------RELGVNVHQGFKPVYIIDKTKSKVIAELKEATLSADSVYLASDNDREGEAIA 91 Query: 121 WHLREVIGG--DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 WHL E + ++ R+VFNEIT AI +A PG++++ +V AQQARR +DR+VGY Sbjct: 92 WHLSETLKKELNNKPVYRIVFNEITSQAINEAIKNPGQIDMAKVEAQQARRILDRLVGYE 151 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +SPLLWK I + LSAGRVQSVA+RL+ ERE EIKAFVP+E+W+++A + + Sbjct: 152 ISPLLWKVITKDLSAGRVQSVALRLICEREAEIKAFVPKEYWKIEADFWKDNLPPFKAVL 211 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 K +++ V + A + E + +P PFITSTLQQ AS LG Sbjct: 212 EKIEGKKVEIPDEKSAIEIVENSQNAEAILSEIKRSNRNVEPLPPFITSTLQQEASKILG 271 Query: 299 FGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 F +KTM +AQ LYE G ITYMRTDST ++++A+ + I + FGK+ + Sbjct: 272 FQAQKTMSIAQVLYEGIDLGGERTGLITYMRTDSTRMAEEAITKAQNLIKERFGKELVHP 331 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 + +K+++Q+AHEAIRP+D ES+ + + KLY LIW++F+A QM P K Sbjct: 332 KVRVFKNKQSAQDAHEAIRPTDPFRTPESVAQYLTKEQMKLYTLIWQRFIATQMIPVKLL 391 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 ST++ + AG + G + +G+ K P L ++I K D L L QH Sbjct: 392 STSVKINAGKAEFVSSGAQIMEEGFLKAYPHLYIPLGEKIHQDYAKNDVLEHSPLEKTQH 451 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FT PAR++EASL+KELE +GIGRPSTYA+II T++ R YV +E + F ++G V Sbjct: 452 FTTSPARYTEASLIKELEAKGIGRPSTYATIIETLRKRKYVTMEKKAFLPTQLGSDVNRF 511 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 L + F L N FTA+ME LD+V W V+ ++ + + + E+ Sbjct: 512 LVDKFDYLFNVQFTAEMETKLDEVEYSNIAWNEVVQEYYDQLVALIRQVDVKKEKN---- 567 Query: 590 NQMVLTSIDCPTCGRK-MGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 N + T I C C + M I+ + G FL CS + +CK T N + +G Sbjct: 568 NFVQDTGIVCDVCKQGTMLIKHSKRGDFLSCSRFP-----QCKNTKNFTRDE------DG 616 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 CP+CG+ + + C N P C + Sbjct: 617 NIKIFVPTPLNENCPQCGSPL-MLRTGKYGEFIACSNYPKCKYARPKTLG---------- 665 Query: 709 VECEKCG-SEMHLKMGRFGKYMACTN--EECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 ++C +CG E+ + + G+ N ECK + P+P+ C K Sbjct: 666 IKCPECGIGELTARKSKKGRTFYSCNRYPECKYITN-----------DKPLPIS---CPK 711 Query: 766 SDAY-FVLRDGA-AGVFLAANTFPKSR 790 V + G P + Sbjct: 712 CGNPYIVEKYSREKGKIKIC---PNCK 735 Score = 87.1 bits (214), Expect = 3e-15, Method: Composition-based stats. Identities = 25/85 (29%), Positives = 43/85 (50%), Gaps = 3/85 (3%) Query: 711 CEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA 768 C+ C M +K + G +++C+ +CKNT+ R+ + P PL E C + + Sbjct: 577 CDVCKQGTMLIKHSKRGDFLSCSRFPQCKNTKNFTRDEDGNIKIFVPTPLNE-NCPQCGS 635 Query: 769 YFVLRDGAAGVFLAANTFPKSRETR 793 +LR G G F+A + +PK + R Sbjct: 636 PLMLRTGKYGEFIACSNYPKCKYAR 660 Score = 53.2 bits (126), Expect = 4e-05, Method: Composition-based stats. Identities = 19/93 (20%), Positives = 40/93 (43%), Gaps = 6/93 (6%) Query: 742 ILRNGEVAPPKEDPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 ++R +V K + V + C+ +++ G FL+ + FP+ + T+ +E Sbjct: 556 LIRQVDVKKEKNNFVQDTGIVCDVCKQGTMLIKHSKRGDFLSCSRFPQCKNTKNFTRDED 615 Query: 801 YRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSR 833 + +P L + PQ G+ M+R + Sbjct: 616 GNIKIFVPTPLN--ENCPQC---GSPLMLRTGK 643 >UniRef50_Q256J1 DNA topoisomerase I-fused to SWI domain n=18 Tax=Chlamydiales RepID=Q256J1_CHLFF Length = 862 Score = 636 bits (1641), Expect = 0.0, Method: Composition-based stats. Identities = 284/773 (36%), Positives = 406/773 (52%), Gaps = 86/773 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+L++VESPAK KT+ K LG ++ SS+GH+ DLP Sbjct: 1 MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 G+D H++E Y++LP K++V++++ +LA D +YL+ D DREGEAIA Sbjct: 39 -------AKTFGIDIEHDFEPDYQILPDKQEVINQICKLASSCDVVYLSPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ + + + RV FN ITK A+ +A P E+++ VNAQQARR +DR+VGY +S Sbjct: 92 WHIANQL-PKNTQIQRVSFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKIS 150 Query: 181 PLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS-GEALALQ 237 P+L +K+ + G+SAGRVQSVA++LVV+RE+ I+AFVP E+W + P + Sbjct: 151 PILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIRVFLQDPKTSKTFWAH 210 Query: 238 VTHQNDKPFRPV--------------NKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 + + K + ++ + Q LLE A Y V E K P Sbjct: 211 LYSADGKKWEKELPKGKTEDEILLINSEAKAQHYAELLEDASYRVTRVEAKEKRRNAAPP 270 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNM 334 FITSTLQQ AS F KTM +AQ LYE G ITYMRTDS + +A+N Sbjct: 271 FITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNN 330 Query: 335 VRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQL 393 VR YI D FG++YLP++PN Y SK+ +Q+AHEAIRP+D+++ + L + D LY L Sbjct: 331 VRDYIQDTFGQEYLPKTPNLYTSKKMTQDAHEAIRPTDIHLSPDKLQGKLTNDQHMLYSL 390 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAG-DFRLKARGRILRFDGWTKVMPALRKGD----EDR 448 IW++FVA QM PA YD+ +T+ L+A G +L+F G+ V D E+ Sbjct: 391 IWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKIDDDVAEEENP 450 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508 LP ++ D L +++ Q FTKP RF+EASLVKELEK GIGRPSTYA+I++ IQ R Sbjct: 451 SLPQLHAQDILDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSRE 510 Query: 509 YVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 Y EN+R ++G+I++ LE NF +M+ FTA ME+ L+ +A+++ WK +L F+ Sbjct: 511 YTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFW 570 Query: 569 SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIR-TASTGVFLGCSGYALPPK 627 F + AEK+ V+T IDC C + ++ A F GCS Y Sbjct: 571 DQFLPVVTTAEKEAVI------PRVVTDIDCSACHKGKLVKIWAKNRYFYGCSEYP---- 620 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNP 687 C E E+ + ET CP CG M C N P Sbjct: 621 -ECDFK---TSEEELAFNKDDYAVETP---WDSPCPVCGGEMKVRHGRFG-TFLGCLNYP 672 Query: 688 TCDGYEIEEGEFRIKGYDGPIVECEK--CGSEMHLKMGRFGK-YMACTN-EEC 736 C G + + PI C C ++ K R+ K + +C+ +C Sbjct: 673 KCRGTISLHKKGEEVETEEPIP-CPAIGCSGKIFKKRSRYNKTFYSCSEYPDC 724 Score = 72.4 bits (176), Expect = 7e-11, Method: Composition-based stats. Identities = 20/102 (19%), Positives = 36/102 (35%), Gaps = 7/102 (6%) Query: 697 GEFRIKGYDGPIVECEKC-GSEMHLKMGRFGKYMACTN-EEC--KNTRKILRNGEVAPPK 752 + + ++C C ++ + + C+ EC K + + L + Sbjct: 581 EKEAVIPRVVTDIDCSACHKGKLVKIWAKNRYFYGCSEYPECDFKTSEEELAFNKDDYAV 640 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 E P + PC +R G G FL +PK R T + Sbjct: 641 ETP---WDSPCPVCGGEMKVRHGRFGTFLGCLNYPKCRGTIS 679 >UniRef50_C6P2V7 DNA topoisomerase n=2 Tax=Proteobacteria RepID=C6P2V7_9PROT Length = 876 Score = 636 bits (1641), Expect = 0.0, Method: Composition-based stats. Identities = 282/760 (37%), Positives = 406/760 (53%), Gaps = 73/760 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M L+IVESPAKAKT+ KYLG D+ V +S GH+RDL Sbjct: 1 MATNLLIVESPAKAKTLKKYLGKDFEVLASYGHVRDL----------------------- 37 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VDP N+ YE + K V + + A +ADHI+LA D DREGEAIA Sbjct: 38 ------IPKTGAVDPDDNFAMKYETIARNAKHVDAIAKAAAEADHIFLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDD----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WH+ E++ G RVVF EIT++A+R+A P E++I VNAQQARR +D +VG Sbjct: 92 WHISELLKGKRALKGKTMQRVVFYEITQSAVREAVAHPREISIPLVNAQQARRALDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS--GEAL 234 + +SPLLW+KI GLSAGRVQS A+RL+VERE EI+ F +E+W V + S +A Sbjct: 152 FNLSPLLWRKIRPGLSAGRVQSPALRLIVERELEIEKFKSQEYWSVHLDSQKNSIPFKAK 211 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY--SVLEREDKPTTSKPGAPFITSTLQQA 292 Q + + ++ + A + L A+ V+ E K P APF TSTLQQ Sbjct: 212 LYQFQGKRMEQLTIGSQAEYDAIHAKLVDAKLPPKVVRVEKKGKQRSPAAPFTTSTLQQE 271 Query: 293 ASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFG 344 A +LG +TM AQ LYE G ITYMRTDS NL+ +AV +R YI DNF Sbjct: 272 AVRKLGMTSDRTMRTAQSLYEGVDIGGQTIGLITYMRTDSVNLANEAVAEMREYIKDNFA 331 Query: 345 KKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQ 402 YLP Y SK +N+QEAHEAIRP+ + +SL+D + D +LY++IW++ +A Q Sbjct: 332 GDYLPVKQPVYKSKSKNAQEAHEAIRPTSILRTPDSLRDHLNIDQMRLYEMIWKRTLASQ 391 Query: 403 MTPAKYDSTTLTV--GAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGD 457 M+PA++D+ ++ + + D +A G+ L F G+ V + ++ LP + +GD Sbjct: 392 MSPARFDTVSVDIRLSSDDTLFRASGQTLVFPGFIGVYMEDVDDAEEEDSAKLPPLVEGD 451 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L + +L QHFT+PP RFSEASLVK LE+ GIGRPSTYA+IIST+Q R Y ++ +RF Sbjct: 452 VLPVDKLYGEQHFTQPPPRFSEASLVKALEEYGIGRPSTYATIISTLQAREYATLDKKRF 511 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 +G +V L E+F ++Y FTA +E+ LD ++ + +W VL+ F+ F + + + Sbjct: 512 MPTDVGRVVIKFLNEHFTRYVDYGFTANLEDELDDISEGKRDWIPVLNEFWKGFNKLISE 571 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV 637 +KD + G + CP CG+ + R G F+GC+GY C T +L Sbjct: 572 -KKDVDRPGTEILEET-----CPKCGKPLSKRLGKRGSFIGCTGYP-----ECDYTRSLG 620 Query: 638 PENEVLNVLE--GEDAETNALRAKRRCP-----KCGTAMDSYLIDPKRKLHVCGNNPTCD 690 E + + G+ +TN L R P + G ++ PKR Sbjct: 621 GEEDAGESRKELGQHPDTNQLVLLLRGPYGPYVQLGEMIEGEKTKPKRVSWPKELPLE-- 678 Query: 691 GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 ++ + + G ++ + +GRFG Y+ Sbjct: 679 -QADLPSALKLLSLPREVGAHPETGKKVIVNIGRFGPYIG 717 Score = 61.3 bits (147), Expect = 2e-07, Method: Composition-based stats. Identities = 13/53 (24%), Positives = 18/53 (33%) Query: 747 EVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEE 799 E + E C K R G G F+ +P+ TR+ EE Sbjct: 571 EKKDVDRPGTEILEETCPKCGKPLSKRLGKRGSFIGCTGYPECDYTRSLGGEE 623 Score = 55.1 bits (131), Expect = 1e-05, Method: Composition-based stats. Identities = 30/146 (20%), Positives = 57/146 (39%), Gaps = 12/146 (8%) Query: 695 EEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKE 753 E+ + G + C KCG + ++G+ G ++ CT EC TR + + ++ Sbjct: 571 EKKDVDRPGTEILEETCPKCGKPLSKRLGKRGSFIGCTGYPECDYTRSLGGEEDAGESRK 630 Query: 754 DPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFP---KSRETRAPLVEELYRFRDRLPEK 810 + P+ + +L G G ++ K++ R +EL + LP Sbjct: 631 ELGQHPDT-----NQLVLLLRGPYGPYVQLGEMIEGEKTKPKRVSWPKELPLEQADLPSA 685 Query: 811 LRYLA---DAPQQDPEGNKTMVRFSR 833 L+ L+ + G K +V R Sbjct: 686 LKLLSLPREVGAHPETGKKVIVNIGR 711 >UniRef50_O83409 DNA topoisomerase 1 n=4 Tax=Treponema RepID=TOP1_TREPA Length = 731 Score = 635 bits (1637), Expect = e-180, Method: Composition-based stats. Identities = 269/757 (35%), Positives = 400/757 (52%), Gaps = 82/757 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESPAKA+TI KYLG+ YVV++S+GH+ DLP S Sbjct: 17 KHLVIVESPAKAQTIEKYLGTQYVVRASMGHVIDLPKS---------------------- 54 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 R+ +D H+++ Y + G+ + + EL+ L++++ ++LA+D DREGEAIA+H Sbjct: 55 -------RLAIDIEHDFQPEYITVRGRAQCLKELRTLSKQSLQVFLASDRDREGEAIAYH 107 Query: 123 LREVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 L + I D R+VFNEIT +AIR A P ++ +VNAQ+ARR +DR+VGY + P Sbjct: 108 LAQSIQAYCDTPIKRIVFNEITPHAIRAAIGHPVPIDTAKVNAQKARRVLDRLVGYHLCP 167 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLW K+ GLSAGRVQSVA+RL+ ERE E+K FVPEE+W V+ + ++ + + Sbjct: 168 LLWHKVKNGLSAGRVQSVALRLICEREVEVKRFVPEEYWTVEGTFEKDK-KSFSALLILI 226 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 K +K++ +A+ L ++ V + +P PF TSTLQQ A+ RLGF Sbjct: 227 QGKKAVFKSKQEATSAIGLFSQSEARVSQIRSFEKNVRPKQPFTTSTLQQCAANRLGFTS 286 Query: 302 KKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 +KTM +AQ+LYE G ITYMRTDS +S+ AV VR +I+ +F LP +PN Sbjct: 287 RKTMQVAQQLYEGVSLGTHRVGLITYMRTDSVRVSEAAVKEVRAWIATHF-SDALPGTPN 345 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 +YA+K SQ+AHEAIRP+ V E +K + D +LY LIW +FVA QMT A+ S T Sbjct: 346 RYAAKGKSQDAHEAIRPTYVAHTPERIKAHLTRDQIRLYTLIWERFVASQMTDARVRSLT 405 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGD-EDRILPAVNKGDALTLVELTPAQHFT 471 + AG A + G+ +V+ L D +LP +G+ + L + QHFT Sbjct: 406 FEITAGPAVFSATETQVIEQGFYRVLKMLSPKDLSKAVLPPTKEGEVVALHNVQSVQHFT 465 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 + P R+++AS+VK LE++GIGRPSTYA IS + DR YV ++ +G++++D L Sbjct: 466 QGPVRYTDASIVKMLEEKGIGRPSTYAPTISVLLDRYYVTRIQKQLMPTPLGKVISDLLT 525 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 F ++++ FTA+ME+ LD+V + +W V+ F+ F++++ KD MR Sbjct: 526 TYFHDVVDVSFTARMESKLDEVEEDKIKWNCVIADFYPAFSEKVSTVMKDL--NSMRGVF 583 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 T + C CG M + G FL C + C+ T + Sbjct: 584 DEKTDVVCSQCGDTMVKKLGRFGFFLACGKFP-----ECRNTQPVPLA------------ 626 Query: 652 ETNALRAKRRCPK--CGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV 709 +CP+ C + +++ + C P CD + + Sbjct: 627 ---------KCPRPACDGNIVGKKTRGRKEFYGCTRFPVCDF---------VTHFKPTFA 668 Query: 710 ECEKCGSEMHLKMGRF-GKYMACTNEECKNTRKILRN 745 C +C + K R G Y AC N EC+ +N Sbjct: 669 VCPQCRCFLVEKSNRRVGTYTACVNPECRYVSPTRKN 705 Score = 71.7 bits (174), Expect = 1e-10, Method: Composition-based stats. Identities = 26/87 (29%), Positives = 35/87 (40%), Gaps = 16/87 (18%) Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPC 763 + V C +CG M K+GRFG ++AC EC+NT+ PVPL + P Sbjct: 585 EKTDVVCSQCGDTMVKKLGRFGFFLACGKFPECRNTQ--------------PVPLAKCPR 630 Query: 764 EKSDAYFVLRDGA-AGVFLAANTFPKS 789 D V + F FP Sbjct: 631 PACDGNIVGKKTRGRKEFYGCTRFPVC 657 Score = 56.6 bits (135), Expect = 4e-06, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 17/37 (45%) Query: 757 PLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 ++ C + V + G G FLA FP+ R T+ Sbjct: 585 EKTDVVCSQCGDTMVKKLGRFGFFLACGKFPECRNTQ 621 >UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria RepID=B8EMQ0_METSB Length = 977 Score = 633 bits (1633), Expect = e-180, Method: Composition-based stats. Identities = 276/775 (35%), Positives = 400/775 (51%), Gaps = 90/775 (11%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +VIVESPAKAK+INKYLG Y V S GH+RDLP + Sbjct: 3 VVIVESPAKAKSINKYLGKGYEVYPSYGHVRDLPAKDGS--------------------- 41 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 VDP ++ ++V K ++E+ + + AD I LATD DREGEAI+WH+ Sbjct: 42 --------VDPDADFAMLWDVDVKSAKRLNEIARAVKDADKIILATDPDREGEAISWHVL 93 Query: 125 EVIGGDD----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 EV+ RVVFN ITK+A+ +A P ++++ V+A ARR +D +VG+ +S Sbjct: 94 EVLKAKKVLKDKPVERVVFNAITKSAVLEAMQHPRQIDVALVDAYLARRALDYLVGFNLS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW+K+ SAGRVQSVA+RLV +RE EI+AFV E+W + A T + ++ Sbjct: 154 PVLWRKLPGARSAGRVQSVALRLVCDRELEIEAFVAREYWSIVAHLRTQADAPFTARLVG 213 Query: 241 QNDKPFRPVN---KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + K ++ + A + LE A + V E E KP P APF TSTLQQ AS +L Sbjct: 214 ADGKKITRLDVGTGAEAAAFKTDLENATFRVAEIEAKPAKRHPSAPFTTSTLQQEASRKL 273 Query: 298 GFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 GF +TM +AQRLYE G ITYMRTD +L+ +A+ R I+ FG Y+P Sbjct: 274 GFAPARTMQLAQRLYEGADIDGETVGLITYMRTDGVDLAPEAITSARSVIARQFGDAYVP 333 Query: 350 ESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 ++P +Y K +N+QEAHEAIRP+D+ + ++ +E D KLY+LIW + +A QM A+ Sbjct: 334 KAPRKYTVKAKNAQEAHEAIRPTDLARLPRAVARALEPDQAKLYELIWTRTIASQMESAE 393 Query: 408 YDSTTLTVGA----GDFRLKARGRILRFDGWTKVMPALRKGDEDRI---LPAVNKGDALT 460 + TT+ + A L+A G+++RFDG+ K+ R ++D LP + K + L Sbjct: 394 LERTTVDIEALAGARKLDLRATGQVVRFDGFLKLYQEGRDDEDDDESARLPDMAKDERLK 453 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 + QHFT+PP RF+EA+LVK +E+ GIGRPSTYAS ++ +++R YVR+E +R + E Sbjct: 454 RERIEADQHFTEPPPRFTEATLVKRMEELGIGRPSTYASTLAVLRERDYVRIEKKRLHPE 513 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF--------- 571 G +VT LE F + YDFTA +E LD+V+NHE +WK VL F+ DF Sbjct: 514 DKGRLVTAFLEAFFARYVGYDFTADLEEKLDRVSNHEIDWKQVLRDFWLDFSGALAGTKD 573 Query: 572 ---TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGR-KMGIRTASTGVFLGCSGYALPPK 627 T+ LD+ + P + CP+CG K+ ++ G F+GCS Y Sbjct: 574 LRTTEVLDRLNEILGPHIFPPKEDGSDPRGCPSCGEGKLSLKLGKFGAFIGCSNYP---- 629 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAM------------DSYLID 675 CK T L + E E +++ P G + Sbjct: 630 -ECKFTRTLAAPDGA----EANGGERPGVKSLGVDPDSGEEITLRDGRFGVYVQQGEGEK 684 Query: 676 PKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 PKR P E + + + + +GR+G Y+ Sbjct: 685 PKRSSLPPTIAP---ADLTLEQAIALLSLPREVARHPESKEPIVAGIGRYGPYVQ 736 Score = 58.2 bits (139), Expect = 1e-06, Method: Composition-based stats. Identities = 26/73 (35%), Positives = 36/73 (49%), Gaps = 3/73 (4%) Query: 711 CEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKI-LRNGEVAPPKEDPVPLPELPCEKSD 767 C CG ++ LK+G+FG ++ C+N ECK TR + +G A E P S Sbjct: 604 CPSCGEGKLSLKLGKFGAFIGCSNYPECKFTRTLAAPDGAEANGGERPGVKSLGVDPDSG 663 Query: 768 AYFVLRDGAAGVF 780 LRDG GV+ Sbjct: 664 EEITLRDGRFGVY 676 Score = 53.9 bits (128), Expect = 3e-05, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 24/65 (36%), Gaps = 4/65 (6%) Query: 734 EECKNTRKILRNGEVAPPKEDPVPLPEL---PCEKSD-AYFVLRDGAAGVFLAANTFPKS 789 ++ + T + R E+ P P C L+ G G F+ + +P+ Sbjct: 572 KDLRTTEVLDRLNEILGPHIFPPKEDGSDPRGCPSCGEGKLSLKLGKFGAFIGCSNYPEC 631 Query: 790 RETRA 794 + TR Sbjct: 632 KFTRT 636 >UniRef50_Q1RIM1 DNA topoisomerase 1 n=35 Tax=Rickettsiales RepID=TOP1_RICBR Length = 800 Score = 629 bits (1621), Expect = e-178, Method: Composition-based stats. Identities = 292/771 (37%), Positives = 421/771 (54%), Gaps = 77/771 (9%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LVIVESPAKAKTINKYLG ++ V +S GHIRDLP+ Sbjct: 2 KLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPS------------------------ 37 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 + V P N+ Y++ K V + + A+KA+ +YLATD DREGE+I+WH+ Sbjct: 38 -----KKGSVIPDENFSMKYDISEKAGKYVDAIIKDAKKAESVYLATDPDREGESISWHI 92 Query: 124 REVIGGDDAR-----YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 EVI + + RV FNEITK AI A P +L+ + VNAQQARR +D +VG+ Sbjct: 93 AEVIKEKNKVKSDDFFKRVAFNEITKKAITHAIENPRKLDNNLVNAQQARRALDYLVGFT 152 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +SPLLW+K+ SAGRVQSVA+RL+ ERE EI+ F EE+W++ + E ++ Sbjct: 153 LSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMLNSNNELFTAKL 212 Query: 239 THQND---KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 TH ND + F N ++ + L+ + V + E K +P PFITS+LQQ A+ Sbjct: 213 THINDQKLEKFSITNDKEAKDLTEKLKSQNFHVDKIEKKQQKRQPQPPFITSSLQQEAAR 272 Query: 296 RLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 +LGF KKTM +AQ+LYE G ITYMRTD LS DAV+ +R I+ ++G KY Sbjct: 273 KLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAVDEIRKLINKDYGDKY 332 Query: 348 LPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTP 405 LP SP Y SK +N+QEAHEAIRP+++N + LK+ +E D KLY+LIW++ +ACQM Sbjct: 333 LPSSPRIYKSKVKNAQEAHEAIRPTNINYIPNDLKEKLEKDYYKLYELIWKRTIACQMEN 392 Query: 406 AKYDSTTLTV--GAGDFRLKARGRILRFDGWTKVMPA---LRKGDEDRILPAVNKGDALT 460 D T+ ++ +A G + FDG+ KV +E+++LP + + + L Sbjct: 393 VIMDLVNATLASENKEYLARANGSTIAFDGFYKVYRESIDDEAEEENKMLPPLKEQEHLK 452 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 E+ P QHFT+PP R+SEASLVK+LE+ GIGRPSTYA+I+S +QDR YV +E +RF E Sbjct: 453 TKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYATILSVLQDRKYVTLEKKRFIPE 512 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK 580 ++G +VT L F++ + YDFTA +EN LD++A + EWK+ L +F++ F ++ K Sbjct: 513 ELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKSALGNFWNGFNHNIESVNK 572 Query: 581 DPEEGGMRPNQMVL---------TSIDCPTCG-RKMGIRTASTGVFLGCSGYALPPKERC 630 + Q L S CP+C ++ ++ G FL CS Y + Sbjct: 573 QNITEIISYVQQALDYHIFGENKDSKVCPSCKTGELSLKLGKFGAFLACSNYPECNFRKS 632 Query: 631 KTTINLVPE---------NEVLNVLEGEDAETNALRAKRRCP--KCGTAMDSYLIDPKRK 679 + N E NE + + ++ L+ P + G +DS I PKR Sbjct: 633 IVSGNDNNEADGEAKDIVNENKVLGKDKEGIEIYLKKGPYGPYIQYGEQVDS-KIKPKRS 691 Query: 680 LHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 G N + ++ I ++ G E+ + G+FG Y+ Sbjct: 692 PLPAGLN---QNDITLDMALKLLSLPLKIGNHKESGEEVLVGYGKFGPYIK 739 Score = 51.2 bits (121), Expect = 2e-04, Method: Composition-based stats. Identities = 29/126 (23%), Positives = 51/126 (40%), Gaps = 8/126 (6%) Query: 698 EFRIKGYDGPIVECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDP 755 ++ I G + C C E+ LK+G+FG ++AC+N EC + I+ + + Sbjct: 587 DYHIFGENKDSKVCPSCKTGELSLKLGKFGAFLACSNYPECNFRKSIVSGNDNNEADGEA 646 Query: 756 VPLPE----LPCEKSDAYFVLRDGAAGVF--LAANTFPKSRETRAPLVEELYRFRDRLPE 809 + L +K L+ G G + K + R+PL L + L Sbjct: 647 KDIVNENKVLGKDKEGIEIYLKKGPYGPYIQYGEQVDSKIKPKRSPLPAGLNQNDITLDM 706 Query: 810 KLRYLA 815 L+ L+ Sbjct: 707 ALKLLS 712 >UniRef50_B1M0P4 DNA topoisomerase n=14 Tax=Alphaproteobacteria RepID=B1M0P4_METRJ Length = 894 Score = 627 bits (1616), Expect = e-178, Method: Composition-based stats. Identities = 286/852 (33%), Positives = 418/852 (49%), Gaps = 111/852 (13%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 +V+VESPAKAKTINKYLG DY V +S GHIRDLP + Sbjct: 2 KVVVVESPAKAKTINKYLGRDYEVIASFGHIRDLPPKDGS-------------------- 41 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 VDP ++ +E+ VSE+ + + AD + LATD DREGEAI+WH+ Sbjct: 42 ---------VDPEQDFRMVWELADRGASRVSEIAKAVKGADKLILATDPDREGEAISWHV 92 Query: 124 REVIGGDDA----RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 E + A RV FN ITK ++ QA KP E++ V+A ARR +D +VG+ + Sbjct: 93 LEALTARKALKGIPVERVTFNAITKASVEQAMRKPREIDQALVDAYLARRALDYLVGFNL 152 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP+LW+K+ SAGRVQSVA+RLVVERE EI+ F P E+W + A+ TT G ++ Sbjct: 153 SPVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEARLV 212 Query: 240 HQNDKPFRPVN---KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 + K + ++ E+ A LE A + V E KP P PF TSTLQQ AS + Sbjct: 213 GADGKRIQRLDVGTGEEAAAFRRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQEASRK 272 Query: 297 LGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LG +TM +AQRLYE G ITYMRTD +++ +A+ R I FG +Y+ Sbjct: 273 LGMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDARRVIGKEFGDRYV 332 Query: 349 PESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPA 406 P+ P +Y+ K +N+QEAHEA+RP+D+ + +++ +E + +LY+LIW + +A QM A Sbjct: 333 PDVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIWTRTMASQMESA 392 Query: 407 KYDSTTLTVGAG----DFRLKARGRILRFDGWTKVMPALRKGDE---DRILPAVNKGDAL 459 + + TT+ V A L+A G++++FDG+ + + +E R LP + GD L Sbjct: 393 ELERTTVDVTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPPMKAGDPL 452 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 T ++ QHFT+PP R+SEASLVK +E+ GIGRPSTYA+++ T++DR YV++E +R Sbjct: 453 TRERISATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVKIEKKRLQP 512 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 E G +VT LE FR + YDFTA +E LD+V+N E +W+AVL F+ DF+ + + + Sbjct: 513 EDKGRLVTGFLESFFRRYVEYDFTAGLEEQLDRVSNAEIDWRAVLRDFWRDFSAAIGETK 572 Query: 580 KDPEEGGMRPNQMVLTSI------------DCPTCGRK-MGIRTASTGVFLGCSGYALPP 626 + + +L CPTCG + ++ G F+GCS Y Sbjct: 573 ELRVADVLEALNGLLGPHIFPDKGDGSNPRTCPTCGSGQLSLKLGKFGAFIGCSNYP--- 629 Query: 627 KERCKTTINLVPEN-EVLNVLEGEDAETNALRAKRRCPKCGTAM---------------- 669 CK T L + + +R P G + Sbjct: 630 --ECKYTRQLSATGIDGDGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFLQLGEA 687 Query: 670 --DSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK 727 + PKR G +P+ + + + G + +GRFG Sbjct: 688 STEKGAEKPKRSSLPKGLSPS---DVDLNKALALLALPREVARHPETGEPILANLGRFGP 744 Query: 728 YMA-----------------CTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYF 770 Y+ N + G DP P E S Sbjct: 745 YVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRLAADPGR-PLGKDEASGRDL 803 Query: 771 VLRDGAAGVFLA 782 V++ G G ++ Sbjct: 804 VVKAGKYGPYVT 815 Score = 52.0 bits (123), Expect = 1e-04, Method: Composition-based stats. Identities = 8/33 (24%), Positives = 14/33 (42%), Gaps = 1/33 (3%) Query: 763 CEKSD-AYFVLRDGAAGVFLAANTFPKSRETRA 794 C L+ G G F+ + +P+ + TR Sbjct: 604 CPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQ 636 >UniRef50_D0KVS8 DNA topoisomerase n=6 Tax=Gammaproteobacteria RepID=D0KVS8_HALNC Length = 834 Score = 625 bits (1611), Expect = e-177, Method: Composition-based stats. Identities = 277/815 (33%), Positives = 410/815 (50%), Gaps = 83/815 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESPAKAKTI KYLG Y V +S GH+RDL Sbjct: 1 MSQTLVIVESPAKAKTIKKYLGPGYEVLASYGHVRDL----------------------- 37 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VD H++ +Y ++ + V +K+ + +D + LATD DREGEAI+ Sbjct: 38 ------IPKDGAVDTAHDFAMNYTLIDKNVRHVDAIKKALKSSDILLLATDPDREGEAIS 91 Query: 121 WHLREVIG----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WHLRE++ + RVVF EITK A+++A P +L+ID +NAQQARR +D +VG Sbjct: 92 WHLRELLAEAGLLKNKTAQRVVFYEITKKAVQEAVAHPRDLSIDLINAQQARRALDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALA- 235 + +SPLLWKKI GLSAGRVQS A+RL+VERE EI+AF P+E+W + A + Sbjct: 152 FNLSPLLWKKINPGLSAGRVQSPALRLIVEREAEIEAFNPQEYWTILADCQADRAAEKSR 211 Query: 236 -----LQVTHQNDKPFRPVNKEQTQAAVSLLEKARY---SVLEREDKPTTSKPGAPFITS 287 L + Q + F N+ Q+A S + +A +V E + P PF TS Sbjct: 212 FNARLLTLDGQKAEQFTLTNETDAQSARSRILEAAAGTLTVRSVEKRERKRNPAPPFTTS 271 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYI 339 TLQQ +LG + M +AQ LYE G ITYMRTD+ LS+DA+ +R +I Sbjct: 272 TLQQEGVRKLGLSASRVMRLAQELYEGVDIGAGTVGLITYMRTDAVTLSEDALTQIRAHI 331 Query: 340 SDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQ 397 D +G YLP SPN+Y +K +N+QEAHEAIRP+ +S++ + D +LY++I+++ Sbjct: 332 GDKYGAAYLPASPNRYKTKSKNAQEAHEAIRPTSAAHTPDSVRAFLNKDQFRLYEMIFKR 391 Query: 398 FVACQMTPAKYDSTTLTVGAGD-FRLKARGRILRFDGWTKVMPALRKG-----DEDRILP 451 VA QMTPA YD ++ + D +A G L+F G+ + DEDR LP Sbjct: 392 AVASQMTPAVYDQVSVDLAVNDQHSFRANGSTLKFPGFIALYREDEDDASGDNDEDRRLP 451 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR 511 + GD + L ++ QHFT+PP RF+EASLVK LE+ GIGRPSTYASIIST+Q R YV Sbjct: 452 PLTVGDKIALNDIAADQHFTEPPPRFTEASLVKTLEEYGIGRPSTYASIISTLQAREYVL 511 Query: 512 VENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 ++ RRF MG +V L + FR++++Y+FTA++E+ LD V+ E +W ++ F++ F Sbjct: 512 LDQRRFKPTDMGRVVNGFLTDYFRDIVDYEFTAKLEDDLDAVSRGERDWVPLMREFWTPF 571 Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG--------YA 623 +++ ++ + + P G+ + +R G F +A Sbjct: 572 HDRVEHTNENVTRQEAAQGRELGID---PKSGKPVSVRLGRFGPFAQIGTKDDEEKPKFA 628 Query: 624 LPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVC 683 + + TI L ++ + + + G Sbjct: 629 SLKRSQSIATITLDEALDLFQLPRKLGETPEGEPVEVAIGRFG---PFVKFGKMYASLGK 685 Query: 684 GNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKIL 743 ++P IK + + + ++ GR+G Y+ + K KI Sbjct: 686 DDDPYTIELPRALEIIEIKKLAEKNRYITQFDNGVSVQNGRYGPYIT----DGKKNAKIP 741 Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG 778 ++ +DP L C A + A G Sbjct: 742 KD-------KDPKSLTLEECVALLAAAPEKKSARG 769 >UniRef50_Q9ZMV7 DNA topoisomerase 1 n=47 Tax=Epsilonproteobacteria RepID=TOP1_HELPJ Length = 736 Score = 622 bits (1604), Expect = e-176, Method: Composition-based stats. Identities = 275/800 (34%), Positives = 417/800 (52%), Gaps = 85/800 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+IVESPAKAKTI +L +Y V +S GH+RDL +K A K D Sbjct: 2 KHLIIVESPAKAKTIKNFLDKNYEVVASKGHVRDL---------------SKFALGIKID 46 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 E G + +Y V +++V ++ +L++KA Y+ATD DREGEAI +H Sbjct: 47 ETG-------------FTPNYVVDKDHKELVKQIIELSKKASITYIATDEDREGEAIGYH 93 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 + +IGG Y R+VF+EIT+NAI P ++++ +VNAQQARR +DR+VG+ +S L Sbjct: 94 VACLIGGKLESYPRIVFHEITQNAILNVLKTPRKIDMFKVNAQQARRLLDRIVGFKLSSL 153 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 + KI +GLSAGRVQS A++LV++RE+EI+ F P ++ +DA P EA + Sbjct: 154 IASKITKGLSAGRVQSAALKLVIDREKEIRPFKPLTYFTLDALFE-PHLEAQLISYKGNK 212 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K +++++ Q + LEK Y + K S PF+TSTLQQ+AS+ LGF Sbjct: 213 LKAQELIDEKKAQEIKNELEKESYIISSIIKKSKKSPTPPPFMTSTLQQSASSLLGFSPT 272 Query: 303 KTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 KTM +AQ+LYE G ITYMRTDS N++++A+ R I ++GK YLP Sbjct: 273 KTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARAKILKDYGKDYLPPKAKV 332 Query: 355 YASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 Y+SK +N+QEAHEAIRP+ + + +LKD ++ + KLY LI+++F+A QM A ++S + Sbjct: 333 YSSKNKNAQEAHEAIRPTSIILEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQS 392 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 + V KA GR L FDG K++ D+D++LP + + D + L +L H T+ Sbjct: 393 VVVACEKGEFKASGRKLLFDGHYKILG---NDDKDKLLPNLKENDPIKLEKLESNAHVTE 449 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PPAR+SEASL+K LE GIGRPSTYA IS +Q+R Y++VE ++ A + V + LE+ Sbjct: 450 PPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVIEILEK 509 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 +F E+++ F+A +E LD +A ++A+++ VL F+ F +++ +K+ + Sbjct: 510 HFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNIISQKVHEK-- 567 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 T CP CG ++ + + G F+ C+ Y +CK + Sbjct: 568 --TGQSCPKCGGELVKKNSRYGEFIACNNYP-----KCKYIK--------------QTEN 606 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 N + C KCG M C N P C + + K V+C Sbjct: 607 ANDEAKQELCEKCGGEMVQKFS-RNGAFLACNNYPECKNTKSLKNTPNAKET-IEGVKCP 664 Query: 713 KCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFV 771 +CG ++ LK + G + C N +C + CEK Sbjct: 665 ECGGDIALKRSKKGSFYGCNNYPKCNFLSNHKPINK--------------RCEKCHYLMS 710 Query: 772 LRDGAAGVFLAANTFPKSRE 791 R + +E Sbjct: 711 ERIYRKKKAHEC---IQCKE 727 Score = 94.4 bits (233), Expect = 2e-17, Method: Composition-based stats. Identities = 26/100 (26%), Positives = 45/100 (45%), Gaps = 10/100 (10%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKED 754 + K ++ C KCG E+ K R+G+++AC N +CK ++ + A Sbjct: 557 KNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKYIKQTENANDEAK---- 612 Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 + CEK V + G FLA N +P+ + T++ Sbjct: 613 -----QELCEKCGGEMVQKFSRNGAFLACNNYPECKNTKS 647 Score = 57.4 bits (137), Expect = 2e-06, Method: Composition-based stats. Identities = 10/52 (19%), Positives = 18/52 (34%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAP 795 G+ + C K V ++ G F+A N +PK + + Sbjct: 553 EAGKKNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKYIKQT 604 >UniRef50_B1VM20 DNA topoisomerase n=6 Tax=Streptomyces RepID=B1VM20_STRGG Length = 963 Score = 617 bits (1591), Expect = e-175, Method: Composition-based stats. Identities = 306/867 (35%), Positives = 423/867 (48%), Gaps = 105/867 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ LVIVESPAKAKTI YLG YVV++SVGHIRDLP + Sbjct: 11 GRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVP---------------- 54 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 DE V R+GVD H+++ Y V K+ V +LKQL ++D ++LATD DREGEAIAW Sbjct: 55 DEYTGEVRRLGVDVEHDFQPIYVVNADKKAQVRKLKQLLAESDELFLATDEDREGEAIAW 114 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL+EV+ R+VF+EITK+AIR A P ELN V+AQ+ RR +DR+ GY VSP Sbjct: 115 HLQEVLR-PKVPVHRMVFHEITKDAIRAAVANPRELNQRMVDAQETRRILDRLYGYEVSP 173 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP------------ 229 +LWKK+ LSAGRVQSVA RLVVERERE AF E+W++ T Sbjct: 174 VLWKKVMPKLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGKFATGRTGDASDPSNLT 233 Query: 230 ------SGEALALQVTHQNDKPFR-------PVNKEQTQAAVSLLEKARYSVLEREDKPT 276 G +A D + +++ +A + L + ++V E KP Sbjct: 234 ARLSAVDGRRIAQGRDFGPDGQLKAGSAQTLHLDETNARALAAALADSSFTVRSVESKPY 293 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 P APF T+TLQQ AS +LGFG K TM +AQ+LYE G+ITYMRTDST LS AV R Sbjct: 294 RRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSDTAVAAAR 353 Query: 337 GYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 ++ +G YLPE P YA K +N+QEAHEAIRPS + + D +LY+LIW Sbjct: 354 AQVTQLYGASYLPEKPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIW 413 Query: 396 RQFVACQMTPAKYDSTTLTV-----GAGDFRLKARGRILRFDGWTKVM------PALRKG 444 ++ VA QM A +S T+ + D A G+ + F G+ K P Sbjct: 414 KRTVASQMKDATGNSVTVKIGGRASDGRDAEFSASGKTITFHGFMKAYVEGADDPNAELD 473 Query: 445 DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTI 504 D +R LP V +GDAL+ E+T H TKPPAR++EASLVKELE+R IGRPSTYASII TI Sbjct: 474 DRERRLPQVAEGDALSADEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTI 533 Query: 505 QDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 DRGYV + + V + LE++F L++YDFTA+ME+ LD+++ EA+ L Sbjct: 534 LDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRISRGEAQSVPWL 593 Query: 565 DHFFSDFTQQLDKAEKDPEE----------GGMRPNQMVLTSIDCPTC-----GRKMGIR 609 F+ D A GG++ L +ID G + +R Sbjct: 594 KRFYFGADAGDDTAGAGSASDAGNGDGDHLGGLKALVTDLGAIDAREISSFPVGNDIKLR 653 Query: 610 TASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAM 669 G ++ +R +L P+ + + E A+ + P G + Sbjct: 654 VGRYGPYIERGEKDAEGHQRADVPEDLAPDELTVELAEELLAKPSGDFELGADPATGNQI 713 Query: 670 DSY---------LIDPKRKLHVCGNNPTCDGYEIEEGE----------FRIKGYDGPIVE 710 + + P+ N + + ++ + E Sbjct: 714 IAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLADALKLMSLPRVVGE 773 Query: 711 CEKCGSEMHLKMGRFGKYMACTNEECKN--------------TRKILRNGEVAPPKEDPV 756 + G E+ + GR+G Y+ + ++ I + Sbjct: 774 DAE-GVEITAQNGRYGPYLK-KGTDSRSLTSEDQLFDITLEEALAIYAQPKQRGRAAAKP 831 Query: 757 PLPELPC-EKSDAYFVLRDGAAGVFLA 782 PL EL S A V++DG G ++ Sbjct: 832 PLKELGTDPVSGAPVVVKDGRFGAYVT 858 >UniRef50_C1D174 DNA topoisomerase n=34 Tax=cellular organisms RepID=C1D174_DEIDV Length = 966 Score = 617 bits (1590), Expect = e-175, Method: Composition-based stats. Identities = 277/772 (35%), Positives = 395/772 (51%), Gaps = 64/772 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESPAKA+TI KYLG Y V+SS+GHIRDLP S S + Sbjct: 1 MARTLVIVESPAKARTIEKYLGKGYAVESSIGHIRDLPKSASDIPEKY------------ 48 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +G R+G+D ++++ Y V P K + V++L++LA AD I LATD DREGE+IA Sbjct: 49 ---KGKAWARLGLDIENDFQPLYVVAPDKRQHVAKLRKLAADADEIILATDDDREGESIA 105 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL + + R+VF+EITK AI+ A P +++ + V AQ+ARR +DR+ GY VS Sbjct: 106 WHLFQELK-PKVPVKRMVFHEITKEAIQAAIAHPRQIDTNLVEAQEARRALDRLYGYEVS 164 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+A LSAGRVQSVA R++VERERE FV +W++ + T G+ ++T Sbjct: 165 PVLWKKVAPKLSAGRVQSVATRMLVERERERMRFVSATWWDLLVTGKTGDGQTFPARLTD 224 Query: 241 -------------------QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 + R + + + QA + L +V E+KP T +P Sbjct: 225 VGGQRLAAGKDFDPLTGRLKEGAAVRLLTEAEAQALTAGLTGQALTVTSAEEKPFTQRPY 284 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 APFITSTLQQ S +LGF +TM AQ+LYE GYITYMRTDSTNLS +AV R ++ Sbjct: 285 APFITSTLQQEGSRKLGFAATRTMRAAQKLYEGGYITYMRTDSTNLSVEAVTAARTQVTQ 344 Query: 342 NFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVN-VMAESLK-DMEADAQKLYQLIWRQF 398 +G +L P YA K +N+QEAHEAIRP+ + +SL+ ++ D +LY LIW++ Sbjct: 345 MYGPAFLHPQPRVYAKKAKNAQEAHEAIRPAGSSFRTPDSLRGELGGDEWRLYDLIWKRT 404 Query: 399 VACQMTPAKYDSTTLTVGA---GDFR--LKARGRILRFDGWTKVM------PALRKGDED 447 VA QM A+ S + +G G L A GR + F G+ + P D D Sbjct: 405 VASQMADARGRSLRVRLGGQAQGGETVGLSASGRTIDFPGFLRAYVEGSDDPNAALEDRD 464 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 LP + +G +T + P H T+PPAR++EASLV+ LE GIGRPSTYASI+ TIQDR Sbjct: 465 TPLPPLKEGQQVTAETVRPESHETQPPARYTEASLVQALEAAGIGRPSTYASILGTIQDR 524 Query: 508 GYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 GY + + + LE +F +L++YDFTA+ME LD +A A L F Sbjct: 525 GYATKKGQALVPTWTAFATSALLEHHFGKLVDYDFTARMEEDLDDIAGGRASRVPYLRRF 584 Query: 568 FSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPT-CGRKMGIRTASTGVFLGCSGYALPP 626 + Q + + + + +I P G + +R G Y Sbjct: 585 YLGDEGQGMALKPLIDRQMGEIDARGIATIHVPKLDGTGIEVRVGRYGP------YMQRG 638 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNN 686 +++ LVP+ V E + + R G + + + + +N Sbjct: 639 EDKANLPEGLVPDELTAEVAEDLMSRPSGDRVIGTDEASGHPVVARAGRYGPYVTLGDSN 698 Query: 687 PTC--------DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 P D E ++ P + G E+ G++G Y+ Sbjct: 699 PPVRSASLFPGDDLNTLTMERALRLLSLPRLVGVSEGEEVWAMNGKYGPYLK 750 >UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q3SMS7_THIDA Length = 857 Score = 615 bits (1587), Expect = e-174, Method: Composition-based stats. Identities = 292/860 (33%), Positives = 433/860 (50%), Gaps = 86/860 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP+K+K++ KYLG+DY + +S GH+RDL Sbjct: 1 MSK-LVIVESPSKSKSLKKYLGADYDILASYGHVRDLE---------------------- 37 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 R G N+ Y+++ K V + + A+KAD + LATD DREGEAI+ Sbjct: 38 --------PRTGAVDTENFSMKYQIIERNAKHVDAIVKAAKKADEVLLATDPDREGEAIS 89 Query: 121 WHLREVIGGDDARY--SRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 WH+ E++ + RV F EIT++AI+ A P E+ D V+AQQARR +D +VG+ Sbjct: 90 WHISEILKEKKVKTPMKRVAFYEITESAIQDAVRNPREIASDLVDAQQARRALDYLVGFN 149 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +SPLLWKKI+ GLSAGRVQS A+R++VERE EI+AFV E+W + + +A ++ Sbjct: 150 LSPLLWKKISPGLSAGRVQSPALRMIVEREEEIEAFVAREYWTLHLD-SHKGSQAFTAKL 208 Query: 239 THQNDKP---FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 TH + F ++ +++ ++ LE V+ E K P APF TSTLQQA Sbjct: 209 THFKGEKLDQFAVEHEARSKEWLATLESKDARVMRIEKKRRARNPAAPFTTSTLQQAGVR 268 Query: 296 RLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 +LG + M AQ+LYE G ITYMRTDS NL+Q+A+ +R Y+ NF K Y Sbjct: 269 QLGMTTDRVMRTAQQLYEGIDLGEGPVGLITYMRTDSVNLAQEAITDIRKYVGANFDKDY 328 Query: 348 LPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTP 405 LP QY +K +N+QEAHEA+RP+ V ++++ + D +LY+L+W++ VACQMT Sbjct: 329 LPPHAVQYKAKTKNAQEAHEAVRPTSVLRTPDAVRQFLTQDQARLYELVWKRTVACQMTA 388 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELT 465 A++D+ + G+ +A G+ L F G+ V + + LPA+ +G+ L + L Sbjct: 389 AQFDTVAADITVGEGTFRATGQTLAFAGFLAVYQDDEDDEGESKLPALVEGETLPVDRLY 448 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 QHFT+PP R++EASLVK LE+ GIGRPSTYASIIST+QDR YV +E +RF +G + Sbjct: 449 GEQHFTQPPPRYTEASLVKALEEYGIGRPSTYASIISTLQDREYVVLEKKRFQPTDVGRL 508 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 V L +F ++YDFTA++E+ LD V+N + W +L F+S F L KA++D E G Sbjct: 509 VNCFLTRHFSHYVDYDFTAKLEDKLDDVSNGKRVWSRLLGEFWSGFEGDL-KAKQDVERG 567 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 CP C + + ++ + G+F+GCSGY C T L P + Sbjct: 568 -------CPILEACPKCAKPLFMQASKRGLFIGCSGYP-----ECDYTRPLHPATAEGDN 615 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGE----FRI 701 + G+D + L K + G + + +K +E + Sbjct: 616 ILGKDP-ASGLDVKLLSGRFGPYVQIGDMPEDKKAPKPRRASWPKDIPLENATLDLALKF 674 Query: 702 KGYDGPIVECEKCGSEMHLKMGRFGKYM-------ACTNEECKNTRKILRNGEVAPPKED 754 + G + GRFG Y+ + + + R EV + Sbjct: 675 LSLPREVGHHPTTGLPIVANNGRFGPYLLHDGKFKSIPKTDSVYEIDLPRALEVLAMERA 734 Query: 755 PVPLPEL--------PCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDR 806 P P + +R G G + K T A L +++ Sbjct: 735 PRGADSAASVLKNLGPHPEDGKDITVRSGRYGP------YVKHGSTNATLPKDITPEAVT 788 Query: 807 LPEKLRYLADAPQQDPEGNK 826 L E + +A + P Sbjct: 789 LDEAIGLIAARVAKGPAKKP 808 >UniRef50_D0D7V2 DNA topoisomerase n=1 Tax=Citreicella sp. SE45 RepID=D0D7V2_9RHOB Length = 918 Score = 615 bits (1587), Expect = e-174, Method: Composition-based stats. Identities = 284/801 (35%), Positives = 414/801 (51%), Gaps = 115/801 (14%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +V+VESPAKAKTINKYLGSDY V +S GH+RDLP + Sbjct: 3 VVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPAKDGS--------------------- 41 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 VD H++E +E+ K V+ + + + + + LATD DREGEAI+WHLR Sbjct: 42 --------VDTDHDFEMTWEIANDSRKHVAAIAEALKNDNSLILATDPDREGEAISWHLR 93 Query: 125 EVIGG-----DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 E + D SRV FN ITK+A+ +A P E++ V A ARR +D +VG+ + Sbjct: 94 EALTKRRSIKKDTAVSRVTFNAITKSAVTEAMQNPREIDAPLVEAYLARRALDYLVGFNL 153 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP+LW+K+ SAGRVQSV +RL+VERE EI+AF P E+W++ A +TP G+ ++T Sbjct: 154 SPVLWRKLPGARSAGRVQSVCLRLIVEREMEIEAFRPREYWQIKALLSTPRGQEYEARLT 213 Query: 240 HQNDKP---FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 K F N Q + AV + + + E +P+T P APF+TSTLQQ AS + Sbjct: 214 VLGGKKLDRFDIGNATQAELAVQAVASRKLKIDSVEARPSTRNPSAPFMTSTLQQEASRK 273 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 G G + M AQRLYEAG+ITYMRTD +++ +A+ R I+D +GK+Y+P SP Y Sbjct: 274 FGMGARACMNAAQRLYEAGHITYMRTDGIDMAPEAITACRDAIADRYGKEYVPGSPRIYK 333 Query: 357 SK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV 415 +K +N+QEAHE IRP+D+ A SLK E D +KLY LIW++ +ACQM A+ + TT+ + Sbjct: 334 NKAKNAQEAHECIRPTDMTRDAASLKLREDDQRKLYDLIWKRTLACQMEAARLERTTVEI 393 Query: 416 GAGDFR--LKARGRILRFDGWTKVMPALRK---GDEDRILPAVNKGDALTLVELTP---- 466 + D + L+A G+++ FDG+ KV R D++ LP + +G+ + T Sbjct: 394 LSEDRQVGLRATGQVVLFDGFLKVYEEGRDDVSDDDENRLPQIMEGEPAAFAKATLQAQY 453 Query: 467 ----------------------------------AQHFTKPPARFSEASLVKELEKRGIG 492 Q T+PP R++EA+LVK +E+ GIG Sbjct: 454 DKASDKAEDVVEDAPAGMQKSSAAVLSDNGAVLATQSHTQPPPRYTEATLVKRMEELGIG 513 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 RPSTYAS+I+TIQDR YVR E R + E G IVT L FR+ + Y+FTA++EN LD+ Sbjct: 514 RPSTYASVITTIQDREYVRKEQNRLFPEDKGRIVTIFLLNFFRKYVGYEFTAELENELDE 573 Query: 553 VANHEAEWKAVLDHFFSDF------------TQQLDKAEKDPEEGGMRPNQMVLTSIDCP 600 V+ E ++K++L F+ DF ++ LD ++ P + CP Sbjct: 574 VSAGEMDYKSLLAKFWRDFSAAIGETSELRISEVLDVLDEALAPQLYPPREDGSDPRICP 633 Query: 601 TCGRK-MGIRTASTGVFLGCSGYALPPKERCKTTINLVPEN--EVLNVLEGEDAETNALR 657 CG+ + ++T+ TG F+GC Y C T + E +L + + L+ Sbjct: 634 KCGQGRLHLKTSRTGGFVGCGNYP-----ECTYTRPIAGEGADGEERLLGSHEGDEVWLK 688 Query: 658 AKRRCPKC---------GTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 A R P + L G +P E + + Sbjct: 689 AGRFGPYVQRGEPTPENKKPPRASLPKKGGAFLP-GWSPD---DMTLEKAVTLLTLPRVV 744 Query: 709 VECEKCGSEMHLKMGRFGKYM 729 + G E+ +GRFG ++ Sbjct: 745 GMHPE-GGEVKSNLGRFGPFI 764 Score = 49.7 bits (117), Expect = 4e-04, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 33/100 (33%), Gaps = 11/100 (11%) Query: 711 CEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA 768 C KCG +HLK R G ++ C N EC TR I G + Sbjct: 632 CPKCGQGRLHLKTSRTGGFVGCGNYPECTYTRPIAGEGADGEERLLGSHE--------GD 683 Query: 769 YFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLP 808 L+ G G ++ P + P + LP Sbjct: 684 EVWLKAGRFGPYVQRGE-PTPENKKPPRASLPKKGGAFLP 722 >UniRef50_Q47L55 DNA topoisomerase n=4 Tax=Actinomycetales RepID=Q47L55_THEFY Length = 906 Score = 615 bits (1585), Expect = e-174, Method: Composition-based stats. Identities = 300/859 (34%), Positives = 414/859 (48%), Gaps = 105/859 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LVIVESPAKAKTI YLG Y+V+SS+GHIRDLP + Sbjct: 20 GNKLVIVESPAKAKTIAGYLGPGYIVESSIGHIRDLPNKAAEIPARY------------- 66 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + R+GV+ ++E Y V K+ V LK+L +AD +YLATD DREGEAIAW Sbjct: 67 --KDEPWARLGVNVDRDFEPLYVVNADKKAQVKRLKELLAEADELYLATDEDREGEAIAW 124 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HLRE + R+VFNEITK AIR A +LN+ V+AQ+ RR +DR+ GY VSP Sbjct: 125 HLREELK-PTIPVKRMVFNEITKEAIRHAAQHTRDLNLRLVDAQETRRILDRLYGYEVSP 183 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST--------------- 226 +LWKK+ LSAGRVQSVA RLVVERERE AF P E+W + A Sbjct: 184 VLWKKVMPSLSAGRVQSVATRLVVERERERIAFTPAEYWGLKAVFAVLTGTDGADPTTFP 243 Query: 227 ---------TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTT 277 G Q ++ K R +++E + L A+Y+V E KP Sbjct: 244 ATLATVDGDRVAQGRDFTSQGVLRSPKGVRHLDEETARGLAERLAGAQYTVRSVERKPYR 303 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 P APF T+TLQQ AS +LG K+TM +AQRLYE GYITYMRTDST LS+ A+ R Sbjct: 304 RSPYAPFRTTTLQQEASRKLGLSAKQTMQVAQRLYENGYITYMRTDSTTLSESAIAAARA 363 Query: 338 YISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWR 396 ++ +G YLP+ P Y SK +N+QEAHEAIRP+ + + +LY+LIW+ Sbjct: 364 QVARLYGDNYLPDKPRTYTSKVKNAQEAHEAIRPAGDTFRTPAETGLSGVELRLYELIWK 423 Query: 397 QFVACQMTPAKYDSTTLTVGA-----GDFRLKARGRILRFDGWTKVM------PALRKGD 445 + +A QM A +S ++ V A G+I+ F G+ K P D Sbjct: 424 RTIASQMKDAVGESVSVRVAGTSTAGEQVEFSATGKIITFHGFLKAYVEGTDDPQAELDD 483 Query: 446 EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQ 505 +R LP + +GD L + H T+PPAR++EASLVKELE+R IGRPSTYA+II TI Sbjct: 484 RERRLPPLTEGDPLHAQSVDAEGHSTRPPARYTEASLVKELEEREIGRPSTYATIIGTIL 543 Query: 506 DRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD 565 +RGYV + + V LE +F L++YDFTA+ME+ LD +A EAE L Sbjct: 544 ERGYVFKKGSALVPSFLAFAVVQLLERHFSHLVDYDFTARMEDVLDAIARGEAERVPWLR 603 Query: 566 HFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALP 625 F+ Q+ E E G + + + P + +R G +L +G Sbjct: 604 RFYFGADGQIGLKELVNEHLGDIDPKEISS---FPLPDSDIVLRVGRYGPYLERNG---- 656 Query: 626 PKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSY------------- 672 +R +L P+ E A+ N R + P+ G + + Sbjct: 657 --QRVNVPDDLAPDELTKERAEELFAQPNGDRELGKDPETGRTIVAKNGRFGPYVTEVIE 714 Query: 673 -------LIDPKRKLHVCGNNPTCDGYEIEEG--------EFRIKGYDGPIVECEKCGSE 717 PK + P + + E +K P V E G + Sbjct: 715 ETEAEAEEAKPKGR--KKTAAPKPRTASLLKSMSLETITLEDALKLLSLPRVVGEIDGEQ 772 Query: 718 MHLKMGRFGKYM-------ACTNEECKNT------RKILRNGEVAPPKEDPVPLPELPC- 763 + + GRFG Y+ + EE T +++ + + PL EL Sbjct: 773 VTAQNGRFGPYLKKGSESRSLETEEQLFTVTIEEAKELFAQPKKRRTRAAAPPLRELGPD 832 Query: 764 EKSDAYFVLRDGAAGVFLA 782 + V+++G G ++ Sbjct: 833 PVTGKPMVIKEGRFGPYVT 851 >UniRef50_Q28MI5 DNA topoisomerase n=13 Tax=Rhodobacterales RepID=Q28MI5_JANSC Length = 907 Score = 612 bits (1579), Expect = e-173, Method: Composition-based stats. Identities = 282/802 (35%), Positives = 398/802 (49%), Gaps = 113/802 (14%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +V+VESPAKAKTINKYLGSDY V +S GH+RDLP+ + Sbjct: 3 VVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPSKDGS--------------------- 41 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 VDP + +E+ +K V + + + + LATD DREGEAI+WHL+ Sbjct: 42 --------VDPEEGFFMKWEIGSDSKKHVKAIVDALKDDNSLILATDPDREGEAISWHLQ 93 Query: 125 EVIGGDDA-----RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 E + A SRV FN ITK+A+ +A +P +++++ V A ARR +D +VG+ + Sbjct: 94 EALTSRKAIKTDTPVSRVTFNAITKDAVTKAMAEPRQVDMELVEAYLARRALDYLVGFNL 153 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP+LW+K+ SAGRVQSV +RLVVERE EI+AF P E+W V A TP G+ + ++T Sbjct: 154 SPVLWRKLPGAKSAGRVQSVCLRLVVEREMEIEAFRPREYWSVRAVLETPRGQTIEARLT 213 Query: 240 HQNDKPFRPVN---KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 K + + AV + + SV + E KP P PF+TSTLQQ AS + Sbjct: 214 VLGGKKLDRYDLPSAAEAGLAVQAVSSRKLSVSDVEAKPANRNPSPPFMTSTLQQEASRK 273 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 LG G K+ M AQRLYEAG+ITYMRTD +++ +AV RG I +G Y+P P Y Sbjct: 274 LGMGAKQAMSTAQRLYEAGHITYMRTDGIDMAPEAVEDARGAIKTRYGVDYVPGKPRIYK 333 Query: 357 SK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV 415 +K +N+QEAHE +RP+D++ A LK E D +KLY LIW++ +A QM A+ + TT+T+ Sbjct: 334 NKAKNAQEAHECVRPTDMSKAANDLKLSEDDQRKLYDLIWKRTIASQMEAARLERTTVTI 393 Query: 416 GAGD--FRLKARGRILRFDGWTKVMPALR----KGDEDRILPAVNKGDALTLV------- 462 + D L+A G+++ FDG+ KV R ++ + LP V+ GD L Sbjct: 394 ASDDREVELRATGQVMLFDGFLKVYEEGRDDAGDDEDSKRLPQVSAGDPLKPSADAMADD 453 Query: 463 ------------------------------ELTPAQHFTKPPARFSEASLVKELEKRGIG 492 + QH T PP R++EA+LVK +E+ GIG Sbjct: 454 YAKYSGDDVVEDDGNGDVRRSKSAILSREGAVLGQQHHTAPPPRYTEATLVKRMEELGIG 513 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 RPSTYASI+ TIQ+RGYV + R E G +VT L F + YDFTA +E LD+ Sbjct: 514 RPSTYASIMDTIQNRGYVIKDKGRLIPEDKGRLVTVFLSNYFNRYVQYDFTADLEQQLDE 573 Query: 553 VANHEAEWKAVLDHFFSDFT------------QQLDKAEKDPEEGGMRPNQMVLTSIDCP 600 V+ + +K VLD F+ DF + LDK + E CP Sbjct: 574 VSAGDRHYKDVLDRFWRDFRAAIDETSDLRIGEVLDKINEVLEPHLFPDPGDGTDPRLCP 633 Query: 601 TCG-RKMGIRTAS-TGVFLGCSGYALPPKERCKTTINLVPENEVL---------NVLEGE 649 CG ++ +RTA G F+GCS Y C+ T P + +L + Sbjct: 634 NCGVGRLSMRTARAGGAFIGCSAYP-----ECRYTRPFGPPDPEAEASAIPPDGKLLGED 688 Query: 650 DAETNALRAKRRCPKCG-TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 + + R P AM P R+ P E + I Sbjct: 689 QGDEIRIFKGRFGPYVQRGAMTEENKKPPRQSIPKDWTPE---ELDLERALMLLSLPRQI 745 Query: 709 VECEKCGSEMHLKMGRFGKYMA 730 + G + +GR+G Y+ Sbjct: 746 GPHPEDGIMVWSNIGRYGPYLK 767 >UniRef50_Q9X909 DNA topoisomerase 1 n=14 Tax=cellular organisms RepID=TOP1_STRCO Length = 952 Score = 612 bits (1579), Expect = e-173, Method: Composition-based stats. Identities = 303/862 (35%), Positives = 429/862 (49%), Gaps = 100/862 (11%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ LVIVESPAKAKTI YLG YVV++SVGHIRDLP+ + + Sbjct: 11 GRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPSGAAEVPEKYTGE---------- 60 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 V R+GVD H+++ Y V K+ V +LK L +++D ++LATD DREGEAIAW Sbjct: 61 ------VRRLGVDVEHDFQPIYVVNADKKSQVKKLKDLLKESDELFLATDEDREGEAIAW 114 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL+EV+ R+VF+EITK+AIR A P ELN V+AQ+ RR +DR+ GY VSP Sbjct: 115 HLQEVLK-PKIPVKRMVFHEITKDAIRAAVANPRELNQKLVDAQETRRILDRLYGYEVSP 173 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT------PSGEALA 235 +LWKK+ LSAGRVQSVA RLVVERERE AF E+W++ + T +L Sbjct: 174 VLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAGDASDPSSLV 233 Query: 236 LQVTHQNDKPFRP-----------------VNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 ++ + + +++ +A + LE R++V E KP Sbjct: 234 ARLQTVDGRRVAQGRDFDSLGQLKSANTLHLDEANARALAAALENTRFAVRSVESKPYRR 293 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY 338 P APF T+TLQQ AS +LGFG K TM +AQ+LYE GYITYMRTDST LS AV+ R Sbjct: 294 SPYAPFRTTTLQQEASRKLGFGAKSTMQVAQKLYENGYITYMRTDSTTLSDTAVSAARAQ 353 Query: 339 ISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 ++ +G YLP P YA K +N+QEAHEAIRPS + + D KLY+LIW++ Sbjct: 354 VTQLYGADYLPPQPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKR 413 Query: 398 FVACQMTPAKYDSTTLTVGAG-----DFRLKARGRILRFDGWTKVM------PALRKGDE 446 VA QM A +S T+ +G D A G+ + F G+ K P D Sbjct: 414 TVASQMKDATGNSVTVKIGGAASDGRDVEFSASGKTITFHGFLKAYVEGADDPNAELDDR 473 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506 +R LP V +GDALT E+T H TKPPAR++EASLVKELE+R IGRPSTYASII TI D Sbjct: 474 ERRLPQVAEGDALTAEEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILD 533 Query: 507 RGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 RGYV + + V + LE++F L++YDFTA+ME+ LD++A EA+ L Sbjct: 534 RGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQSVPWLRR 593 Query: 567 FF-------SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPT-----CGRKMGIRTASTG 614 F+ GG++ L +ID G + +R G Sbjct: 594 FYFGEGDGTGGGGAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGNDIKLRVGRYG 653 Query: 615 VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSY-- 672 ++ +R +L P+ + + E A+ + P G A+ + Sbjct: 654 PYVERGEKDAENHQRADVPEDLAPDELSVELAEELLAKPSGDFELGTDPATGHAIVAKDG 713 Query: 673 -------LIDPKRKLHVCGNNPTCDGYEIEEGE----------FRIKGYDGPIVECEKCG 715 + P+ N + + ++ + + G Sbjct: 714 RYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLDDALKLMSLPRVVGADAE-G 772 Query: 716 SEMHLKMGRFGKYMACTNEECKNTRKILRNGEV---------APPKEDPVPLPELPCEKS 766 E+ + GR+G Y+ + ++ + + E+ A PK+ + P ++ Sbjct: 773 VEITAQNGRYGPYLK-KGTDSRSLQTEDQLFEITLEEALAIYAQPKQRGRAAAKPPLKEL 831 Query: 767 D------AYFVLRDGAAGVFLA 782 V++DG G ++ Sbjct: 832 GTDPVSEKPVVVKDGRFGPYVT 853 >UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms RepID=TOP1_ZYMMO Length = 1217 Score = 612 bits (1579), Expect = e-173, Method: Composition-based stats. Identities = 251/674 (37%), Positives = 360/674 (53%), Gaps = 67/674 (9%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LV+VESPAKAKTI KYLGS Y V +S GHIRDLP+ + Sbjct: 7 KLVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDGS-------------------- 46 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 V+P + + ++ P K + ++ +++D + LATD DREGEAI+WH+ Sbjct: 47 ---------VNPDNGFSMVWQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHI 97 Query: 124 REVIGGDDAR---YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 E++ RV FN ITK A+ A P +L+ D +NA ARR +D +VG+ +S Sbjct: 98 LELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTLS 157 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS--GEALALQV 238 P+LW+K+ SAGRVQSVA+RLVV+RE+EI+ F P+E+W V+A S + +Q Sbjct: 158 PILWRKLPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQW 217 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 Q + +K Q +AA S +E ++V E KP + P PF TSTLQQ A+ +LG Sbjct: 218 RGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKLG 277 Query: 299 FGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK 358 F TM +AQ LYE G ITYMRTD + + A+ R I+ + Y+P+ P QY K Sbjct: 278 FAASHTMRLAQSLYEEGLITYMRTDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQVK 337 Query: 359 -ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV-- 415 +N+QEAHEAIRP+D + + D +LY+LIW++ +A QM AK + TT+ + Sbjct: 338 AKNAQEAHEAIRPTDFSRDKAA----SGDHARLYELIWKRALASQMASAKLERTTVDLTD 393 Query: 416 GAGDFRLKARGRILRFDGWTKVMPA-------LRKGDEDRI-LPAVNKGDALTLVELTPA 467 G G L+ G+++ F G+ + R G E R LP + GDA E+ Sbjct: 394 GTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRAD 453 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFT+PP R+SEASLVK++E GIGRPSTYAS+I ++DR YV +E RF + G ++T Sbjct: 454 QHFTQPPPRYSEASLVKKMEDLGIGRPSTYASVIQVLKDRAYVTLERNRFIPSEAGRLLT 513 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 LE F ++YDFTA +E+SLD+++ A+W+ VLD F+ DF + + + Sbjct: 514 AFLERFFERYVSYDFTAGLEDSLDEISGGRADWQKVLDAFWHDFKPKTAEVMEQQPSAIT 573 Query: 588 RPNQMVLTSIDCPTCGRK-------------MGIRTASTGVFLGCSGYALPPKERCKTTI 634 L P G + ++ G F+ CS Y CK T Sbjct: 574 AELDKFLEPWLFPDKGDGHDPRECPSCHTGRLALKGGRFGAFIACSNYP-----ECKYTR 628 Query: 635 NLVPENEVLNVLEG 648 + ++ E Sbjct: 629 GFGQGEDGVDDNEP 642 Score = 48.9 bits (115), Expect = 8e-04, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 15/32 (46%), Gaps = 1/32 (3%) Query: 763 CEKS-DAYFVLRDGAAGVFLAANTFPKSRETR 793 C L+ G G F+A + +P+ + TR Sbjct: 597 CPSCHTGRLALKGGRFGAFIACSNYPECKYTR 628 Score = 48.9 bits (115), Expect = 9e-04, Method: Composition-based stats. Identities = 23/55 (41%), Positives = 30/55 (54%), Gaps = 3/55 (5%) Query: 710 ECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 EC C + LK GRFG ++AC+N ECK TR + GE +PV L +P Sbjct: 596 ECPSCHTGRLALKGGRFGAFIACSNYPECKYTRGFGQ-GEDGVDDNEPVLLGYMP 649 >UniRef50_P34185 DNA topoisomerase 1 n=39 Tax=Bacteria RepID=TOP1_SYNE7 Length = 883 Score = 608 bits (1568), Expect = e-172, Method: Composition-based stats. Identities = 263/776 (33%), Positives = 388/776 (50%), Gaps = 76/776 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP KA+TI YL DY V++S+GH+RDLP S S Sbjct: 1 MPK-LVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSAS---------------DIP 44 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + +G + +GVD +N+ Y V K+K+V LK + AD + LATD DREGE+I+ Sbjct: 45 TELKGEKWSNLGVDVENNFAPLYIVPKDKKKIVKTLKDALKDADELILATDEDREGESIS 104 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ R+VF+EIT+ AI+ A +++ V+AQ+ RR +DR+VGY +S Sbjct: 105 WHLLQLLQ-PRVPTKRMVFHEITQEAIQAALKNCRDVDQRLVHAQETRRILDRLVGYTLS 163 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWKKIA GLSAGRVQSVAVRL+V+RER +AF +W++ A T +G+ A T Sbjct: 164 PLLWKKIAWGLSAGRVQSVAVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEAKLWTL 223 Query: 241 QN------------------DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 + +++++ +A L+ + V E+KPTT KP Sbjct: 224 AGQRLATGNDFDESTGQIIAGRQVCLLDQQEAEALRDRLQTQPWQVKSLEEKPTTRKPAP 283 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDN 342 PF TSTLQQ ++ +L ++TM +AQ LYE G+ITYMRTDS +LSQ A+ R + Sbjct: 284 PFTTSTLQQESNRKLRLSARETMRVAQSLYERGFITYMRTDSVHLSQQAIEAARSCVEQM 343 Query: 343 FGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 +GK YL P Q+ +K +N+QEAHEAIRP+ + LY LIW++ +A Sbjct: 344 YGKNYLSPQPRQFTTKSKNAQEAHEAIRPAGNTFRLPQETGLSGAEFALYDLIWKRTIAS 403 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------PALRKGDEDRILPAVNK 455 QM A+ ++ + + +A G+ + F G+ + P D + +LPA+ Sbjct: 404 QMAEARQTMLSVLLEVDNAEFRASGKRIDFPGFFRAYVEGSDDPDAALEDREILLPALKV 463 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 GD T EL H T+PPAR++EASLVK LE GIGRPSTYASII TI DRGY ++ + Sbjct: 464 GDRPTCQELAAIGHETQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVSN 523 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF---SDFT 572 VT LE++F +L++ F+A+ME SLD ++N E +W L F+ Sbjct: 524 TLTPTFTAFAVTALLEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYLSQFYRGDRGLE 583 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL--GCSGYALPPKERC 630 +Q+ E + + R + G +R G +L G + Sbjct: 584 EQVKLRESEIDPAAARTVALE---------GLPAKVRIGRFGAYLEAEADGEPIKANLPK 634 Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLH-----VCGN 685 + T + V +L + + L P+ + YL+ + Sbjct: 635 ELTPADLDVQRVETLLRQKTEGPDQLGTH---PETDEPI--YLLTGAYGPYVQLGAATEE 689 Query: 686 NPTCDGYEIEEGE----------FRIKGYDGPIVECEKCGSEMHLKMGRFGKYMAC 731 P + +G + + E + G + +GRFG Y+ C Sbjct: 690 KPKPKRASLPKGMSLETISLEQAVGLLSLPRTLGEHPETGRRIQAGLGRFGPYVVC 745 >UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria RepID=TOP1_XYLFT Length = 815 Score = 607 bits (1566), Expect = e-172, Method: Composition-based stats. Identities = 247/645 (38%), Positives = 369/645 (57%), Gaps = 59/645 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKAKTINKYLG D+ V +S GH+RDL Sbjct: 1 MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDL----------------------- 37 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VDP + + Y+++ EK V + + A+ AD IYLATD DREGEAI+ Sbjct: 38 ------VPKEGAVDPENGFAMRYDLIDKNEKHVEAITKAAKTADSIYLATDPDREGEAIS 91 Query: 121 WHLREVIG----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WH+ E++ D R+VF EIT AI++A KP + D V+AQQARR +D +VG Sbjct: 92 WHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRMIASDLVDAQQARRALDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALA- 235 + +SP+LW+K+ RGLSAGRVQS A+R++VERE EI+AF+ E+W + A T P+ A Sbjct: 152 FNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFITREYWSIHAECTHPAQHFSAK 211 Query: 236 -LQVTHQNDKPFRPVNKEQTQAAVSLLEKA---RYSVLEREDKPTTSKPGAPFITSTLQQ 291 +++ + + F + + AA +++A R + + +K +P PFITSTLQQ Sbjct: 212 LIKLDGKKFEQFTITDSDTAAAAQRRIQQAAQGRLHITDVTNKERKRRPAPPFITSTLQQ 271 Query: 292 AASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 AS +LGF +KTM +AQ+LYE G ITYMRTDS NLS DA++ +R I+ + Sbjct: 272 EASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLITYMRTDSVNLSLDALSEIRDIIARD 331 Query: 343 FGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVA 400 +G LP+ PN Y +K +N+QEAHEA+RP+ + + + +LY+L+W++ VA Sbjct: 332 YGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRTPTQVAPYLSNEEHRLYELVWKRTVA 391 Query: 401 CQMTPAKYDSTTLTVGAGDF-RLKARGRILRFDGWTKVMPALR------KGDEDRILPAV 453 QM PA ++T++ + AG+ +A G + G+ V + DE R LP + Sbjct: 392 SQMIPAILNTTSVDLAAGNEHVFRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGRKLPVM 451 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513 G+ + L + QHFT+PP R++EA+LVK LE+ GIGRPSTYASII T+ R YV +E Sbjct: 452 KTGENVPLERILTEQHFTQPPPRYTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVDME 511 Query: 514 NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ 573 R F +G V+ L +F + ++YDFTA +E+ LD ++ E EW ++ F+ F + Sbjct: 512 GRSFRPTDIGRAVSKFLSSHFTQYVDYDFTAHLEDELDAISRGEEEWIPLMKKFWVPFKE 571 Query: 574 QLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG 618 ++ + ++ +++ PT G+++ R G + Sbjct: 572 LVEDKKDSLDKTDAGSVRLLGID---PTSGKEVSARIGRFGPMVQ 613 >UniRef50_D0LEI6 DNA topoisomerase n=36 Tax=Actinomycetales RepID=D0LEI6_GORB4 Length = 1031 Score = 604 bits (1557), Expect = e-171, Method: Composition-based stats. Identities = 273/738 (36%), Positives = 374/738 (50%), Gaps = 81/738 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 + LVIVESP KA+ I YLGS+YVV+SS GHIRDLP + Sbjct: 16 RRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRGAADVPAKY-------------- 61 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +G R+GV+ N+E Y V P K+ V+ELK L D +YLATD DREGEAIAWH Sbjct: 62 -KGQPWARLGVNVDENFEPLYVVSPDKKSTVTELKSLMRDVDELYLATDGDREGEAIAWH 120 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L E + R+VF+EIT+ AIR A P +L+ID V+AQ+ RR +DR+ GY VSP+ Sbjct: 121 LLETLK-PKIPVKRMVFHEITEPAIRAAAENPRDLDIDLVDAQETRRILDRLYGYEVSPV 179 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS------------ 230 LWKK+ LSAGRVQSVA R++VERERE AFV E+W++DA+ Sbjct: 180 LWKKVMPKLSAGRVQSVATRIIVERERERMAFVSAEYWDIDANMDAGKDASPQTFNARLV 239 Query: 231 ---------GEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 G + + +++ + +A L+ A +V E+KP T +P Sbjct: 240 GVDDARVATGRDFDSRGALKRADGVVVLDETRARALADALDGADITVSSVEEKPYTRRPY 299 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 APF+TSTLQQ A +L F +TM +AQRLYE G+ITYMRTDST LS+ A+N R + Sbjct: 300 APFMTSTLQQEAGRKLRFSSDRTMRIAQRLYENGFITYMRTDSTTLSESAINAARAQARE 359 Query: 342 NFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLYQLIWRQF 398 +G Y+ +P Q+ K +N+QEAHEAIRP+ + +EAD +LY+LIW++ Sbjct: 360 LYGDNYVHPTPRQHTRKVKNAQEAHEAIRPAGESFRTPGQVAGQLEADEFRLYELIWQRT 419 Query: 399 VACQMTPAKYDSTTLTVGA-----GDFRLKARGRILRFDGWTKVM-------PALRKGDE 446 VA QM AK + +L + A GR + F G+ + D Sbjct: 420 VASQMADAKGTTLSLRMTGTASTGETCVFAASGRTITFPGFLSAYVETVDDLAGGQADDA 479 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506 + LP + +G AL EL+ H T PPARF+EASLVK LE+ GIGRPSTYASII TIQD Sbjct: 480 ENRLPQLREGQALRATELSADGHSTNPPARFTEASLVKVLEELGIGRPSTYASIIGTIQD 539 Query: 507 RGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 RGYV + + V LE F+ L++YDFTA +E+ LD++A+ L Sbjct: 540 RGYVVKKGNALVPSWIAFAVVGLLEAYFQGLVDYDFTASLEDDLDEIASGRENRTRWLTE 599 Query: 567 FFSDFTQQLDKAEKDPEEGGMRPNQ----MVLTSIDCPTC---------------GRKMG 607 F+ F AE D E G + L ++ GR + Sbjct: 600 FY--FGDAAPNAEHDAEIAGSEIAKHGGLKKLVGVNLEEIDAREVNSIRLFDDEQGRPVY 657 Query: 608 IRTASTGVFLGCSGY--------ALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAK 659 +R G +L + A P +R ++ P+ L + E + R+ Sbjct: 658 VRVGRFGPYLERNLSAASAASPDAEPDLQRANLPADITPDELTLALAEKLFSTPQEGRSL 717 Query: 660 RRCPKCGTAMDSYLIDPK 677 P G + + Sbjct: 718 GVDPVTGHEIVAKEGRFG 735 >UniRef50_A5CF60 DNA topoisomerase n=2 Tax=Orientia tsutsugamushi RepID=A5CF60_ORITB Length = 788 Score = 603 bits (1555), Expect = e-170, Method: Composition-based stats. Identities = 270/772 (34%), Positives = 410/772 (53%), Gaps = 82/772 (10%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+IVESPAKAKTINKYLGSD+ V +S GH+RDL Sbjct: 2 KLLIVESPAKAKTINKYLGSDFQVVASYGHVRDL-------------------------- 35 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 L V P ++ YE+ P + + + LA+K++ IYLATD DREGE+I+WH+ Sbjct: 36 ---LAKAGSVLPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATDPDREGESISWHI 92 Query: 124 REVIGGDD--ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 EV+ A + R++FNEITK AI A +P ++N++ VNAQQARR +D +VG+ +SP Sbjct: 93 VEVLKEKKIFANFKRIIFNEITKKAIGDALQQPRDINLNLVNAQQARRSLDYLVGFSLSP 152 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLW+K+ SAGRVQSV +RL+ ERE EI F+ +E+W + + E + ++ Sbjct: 153 LLWRKLPGCKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKLIEF 212 Query: 242 ND---KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 + + F N+ Q Q V +E ++ V++ K P PFITS+LQQ A+ +LG Sbjct: 213 DGNKLEKFSITNQSQAQDIVKNIENQQFKVIDITRKQRKKSPPPPFITSSLQQEAAGKLG 272 Query: 299 FGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 F KKTM +AQ+LYE ITYMRTDS LS+D ++ R +IS +FG YLP Sbjct: 273 FTAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNFISSSFGNNYLPR 332 Query: 351 SPNQYASK-ENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMTPAKY 408 + SK +N+QEAHEAIRP ++N+ E L +E D KLY+LIW++ VACQM Sbjct: 333 QIRAFKSKVKNAQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQRTVACQMENVIL 392 Query: 409 DSTTLTVGAGD--FRLKARGRILRFDGWTKVMPALRKGDEDR-ILPAVNKGDALTLVELT 465 + ++ + + KA G + FDG+ KV + +E++ +LP +++ + + + + Sbjct: 393 NLESINFASFNQLHVAKATGSTIAFDGFYKVYKEINDEEENKKLLPNLSQNEVMQVKNIL 452 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 P QHFT+PP R+SEA+LVK LE GIGRPSTYA+IIS +Q+R YV ++ +RF + G + Sbjct: 453 PKQHFTEPPPRYSEATLVKTLEDLGIGRPSTYATIISVLQERDYVILDQKRFIPQNKGRL 512 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 VT L F++ + YDFTA++E+ LD +A W+ +L +F++ F + + E+ Sbjct: 513 VTAFLTAFFKKYVEYDFTAKLEDQLDSIAKGMIGWQEILKNFWTGFNNNVQEIEQYKITD 572 Query: 586 GMRPNQMVLTSIDCP------------TCG-RKMGIRTASTGVFLGCSGYALPPKERCKT 632 + + +L++ P C K+ ++ + G FL C+ Y C Sbjct: 573 IIPQIETLLSNFLFPVQNGETDHKLCTLCKVGKLSLKLSKYGAFLACNNYPS-----CNF 627 Query: 633 TINLVPENEVLNVLE--------GEDAETNALRAKRRCP-----KCGTAMDSYLIDPKR- 678 T N+ E + L G + + P + G + PKR Sbjct: 628 TRNIAAAFENNDNLPKGKNNKAIGYSDDMQKTIYLKEGPFGWYIQAGEDSTNKNDKPKRV 687 Query: 679 KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 + V ++P E ++ I E+ + +GR+G Y+ Sbjct: 688 PISVISSSPQ---DITLETAVKLLALPKVIGLNPNTNKEITVAVGRYGPYLK 736 >UniRef50_D0GKB0 DNA topoisomerase n=1 Tax=Leptotrichia goodfellowii F0264 RepID=D0GKB0_9FUSO Length = 851 Score = 601 bits (1550), Expect = e-170, Method: Composition-based stats. Identities = 281/803 (34%), Positives = 415/803 (51%), Gaps = 71/803 (8%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K LVIVESP+KAKTI K LG Y V +S GH+ DLP + Sbjct: 15 AKKLVIVESPSKAKTIEKILGKGYEVTASYGHVIDLPKT--------------------- 53 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++G+D +N+E Y+V+ GK +V+ +LK+ ++KA +YLA+D DREGEAIAW Sbjct: 54 --------KIGIDVENNFEPKYQVIKGKGEVLKKLKEKSKKASTVYLASDQDREGEAIAW 105 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ I + + R+ FNEITK A+ A P ++N + VNAQQARR +DR+VGY +SP Sbjct: 106 HISNYIKQPE-KTKRIEFNEITKTAVNNAIKNPRDINKNLVNAQQARRLLDRIVGYKISP 164 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLWK I + SAGRVQSVA++L+ + E EIK+FVP+++WEV A L + + Sbjct: 165 LLWKTINKNASAGRVQSVALKLICDLEDEIKSFVPQKYWEVGALLENGINLNLVEILKEK 224 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 DK F ++E + L+ ++ E K T +P F TSTLQQ AS+ LG+G Sbjct: 225 VDKIF---DEEVVKKLKKELKGKSLTLDSIEIKKKTQRPPLVFKTSTLQQLASSYLGYGA 281 Query: 302 KKTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 KTM +AQ+LYE G ITYMRTDST +S DA+NM + YI++++GK+Y+ Sbjct: 282 TKTMRIAQQLYEGLSINGENRGLITYMRTDSTRISMDAINMAKDYITNHYGKEYVGYYVT 341 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 + SK N Q+AHE IRPSD+N+ E +KD + D KLY+LIW +F+ Q KY+ Sbjct: 342 K-NSKSNVQDAHEGIRPSDINLDPEKIKDSLTNDQYKLYKLIWNRFLVSQFAAMKYEQMQ 400 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 + GD++ + + FDG+ K+ + P + +GD+ + +L + TK Sbjct: 401 INAVNGDYKFRGTINKVIFDGYYKIFK-EEDEIKTADFPELKEGDSYLIKKLNVEEGITK 459 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PP R+SEA+LVK+LE GIGRPSTYASI+ T++ R YV + +RF+ +G V + LE+ Sbjct: 460 PPTRYSEATLVKKLESEGIGRPSTYASIVETLKTREYVEIIEKRFHPTFLGYEVKNELEK 519 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 NF ++MN FTA ME LD++ +W +L F+ L++ EK+ E+ R + Sbjct: 520 NFEDIMNVKFTAIMEEDLDKIEEGNVQWVELLKKFYDSLEIHLEQYEKEIEKLKDRRIES 579 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 + S D G M ++T G +L S K K + E + E+ E Sbjct: 580 DVLSSD----GSPMLLKTGRFGKYLV-SETNPEEKITIKGIAVEAEQIEAGKIFIKEEVE 634 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 K G D + + KR + G E E + + PI + Sbjct: 635 KLQANKK------GIPTDFFTENDKRYMLKKGRFGEYLESEDYENDEKRMSLPLPIKQKY 688 Query: 713 KCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL 772 K ++ G +I ++ + CEK F + Sbjct: 689 K-KGTLNEVNG---------------VLQINEEITAIINEDKKIIEEAGVCEKCGRPFEI 732 Query: 773 RDGAAGVFLAANTFPKSRETRAP 795 + G G FLA +P+ + +A Sbjct: 733 KMGRFGKFLACTGYPECKNIKAI 755 Score = 42.8 bits (99), Expect = 0.068, Method: Composition-based stats. Identities = 18/83 (21%), Positives = 28/83 (33%), Gaps = 16/83 (19%) Query: 555 NHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG 614 + + T +++ +K EE G+ C CGR I+ G Sbjct: 690 KGTLNEVNGVLQINEEITAIINEDKKIIEEAGV-----------CEKCGRPFEIKMGRFG 738 Query: 615 VFLGCSGYALPPKERCKTTINLV 637 FL C+GY CK + Sbjct: 739 KFLACTGYP-----ECKNIKAIP 756 >UniRef50_C7NA27 DNA topoisomerase n=20 Tax=Fusobacteriaceae RepID=C7NA27_LEPBD Length = 800 Score = 600 bits (1547), Expect = e-170, Method: Composition-based stats. Identities = 292/788 (37%), Positives = 427/788 (54%), Gaps = 79/788 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESP+KAKTI K LG +Y V +S GH+ DLP + Sbjct: 1 MARKLVIVESPSKAKTIEKILGRNYEVVASYGHVIDLPKT-------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++G+D +N+E Y+V+ GK +V+ +LK+ A+ A+ +YLA+D DREGEAIA Sbjct: 41 ---------KIGIDVENNFEPQYKVIKGKGEVLKKLKEKAKSANAVYLASDQDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ I D + R+ FNEITK A+ A P ++N + VNAQQARR +DR+VGY +S Sbjct: 92 WHISNYIKQPD-KVKRIEFNEITKTAVNNAIKNPRDINDNLVNAQQARRLLDRIVGYKIS 150 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWK I R SAGRVQSVA++L+ + E EI AFVP+++WEV A L Sbjct: 151 PLLWKIINRNASAGRVQSVALKLICDLEDEINAFVPQKYWEVSALIEKDINLNLVKIANE 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + DK F +++ + L+ ++ + E K + +P F TSTLQQ AS+ LG+G Sbjct: 211 KVDKIF---DEKVVKKLKKDLKDESLTIEKIEVKKKSQRPPLVFKTSTLQQLASSYLGYG 267 Query: 301 VKKTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KTM +AQ+LYE G ITYMRTDST +S DA+NM + YI+ N+G+KY+ + Sbjct: 268 ASKTMRIAQQLYEGLPIDGENKGLITYMRTDSTRISVDALNMAKDYITKNYGEKYVGKYV 327 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTPAKYDST 411 SK N Q+AHE IRPSD+N++ + +K + + +LY+LIW +F+ Q +Y+ Sbjct: 328 -VKNSKSNVQDAHEGIRPSDINLVPDDIKVYLTNEQYRLYKLIWDRFLVSQFAAMQYEQM 386 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + GD+ + + FDG+ K+ + P + +G+ + +L + T Sbjct: 387 QINAVNGDYSFRGTINKVIFDGYYKIFK-DEDEIKTGDFPELKEGNVHPIDKLNVEEGIT 445 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPP RFSEA+LVK+LE GIGRPSTYASI+ T++ R YV + +RFY +G V D L Sbjct: 446 KPPTRFSEATLVKKLESEGIGRPSTYASIVETLKTREYVELIEKRFYPTYLGYEVKDELV 505 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 +NF+++MN FTA ME LD+V EW +L F++ L+K K E+ Sbjct: 506 KNFKDIMNVKFTANMEKELDKVEEGTVEWVQLLRAFYNS----LEKEIKKFEKEIEEMKN 561 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFL----------GCSGYALPPKERCKTTINLVPENE 641 + S + G+ M ++T G +L G A+ P+E K I + E E Sbjct: 562 RRVVSDVLDSEGKPMILKTGLYGKYLISETNEKEKVSLKGIAVSPEELKKGEIFIKTEVE 621 Query: 642 VLNVLE----GEDAETNALRAKRRCPKCGTAMDS--YLIDPKR--------KLHVCGNNP 687 L + + + N R + + G ++S Y D KR + + G Sbjct: 622 KLQNNKKGILTDYFDENGNRYVLKVGRFGEYLESENYEKDEKRMSLPAELKQKYKKGAVI 681 Query: 688 TCDGY-EIEEGEFRIKGYDGPIVE----CEKCGSEMHLKMGRFGKYMACTN-EECKNTRK 741 DG +I + R++ D I+E CE CG +K GRFGK++ACT ECK + Sbjct: 682 ELDGVLQINDEMKRLQEIDRKIIEEAGVCEFCGKPYEIKTGRFGKFLACTGYPECKTIKN 741 Query: 742 ILRNGEVA 749 I + G+V Sbjct: 742 I-KTGKVT 748 >UniRef50_B8DVL2 DNA topoisomerase n=14 Tax=Actinobacteridae RepID=B8DVL2_BIFA0 Length = 986 Score = 599 bits (1544), Expect = e-169, Method: Composition-based stats. Identities = 275/777 (35%), Positives = 375/777 (48%), Gaps = 104/777 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LVIVESPAKAK I YLG Y V +SVGHIRDL Sbjct: 4 GSKLVIVESPAKAKKIGGYLGDGYTVLASVGHIRDLAQPSQVPA---------------- 47 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + A + GVD ++ +Y V P K+K VSEL+ A +YLATD DREGEAIAW Sbjct: 48 -DEKAKFGKFGVDVNDGFKPYYIVGPEKKKTVSELRSALRNASELYLATDEDREGEAIAW 106 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL + + R+VF+EIT AIR + E++ + V+AQ+ RR +DR+ GY +SP Sbjct: 107 HLVQTLK-PKVPVKRMVFHEITPEAIRASLEHTREVDNNMVDAQETRRVLDRLYGYELSP 165 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP------------ 229 +LW+K+ GLSAGRVQSVA RL+VERERE AFV +W+V A+ P Sbjct: 166 VLWRKVGPGLSAGRVQSVATRLIVERERERMAFVRAPYWDVVATLCAPDALGEPTDFESR 225 Query: 230 ----SGEALALQVTHQNDKPFR---------PVNKEQTQAAVSLLEKARYSVLEREDKPT 276 +G LA ++D + + Q L AR+ V+ E KP Sbjct: 226 MIALNGTRLATSKDFKSDGTLTDAARTDGVVQLGESQAGDLADALADARFRVISVEKKPY 285 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 +P PF TST+QQAA RLG ++TM AQ LYE GYITYMRTDS LS +A+ R Sbjct: 286 RRRPQPPFTTSTMQQAAGNRLGMSSRQTMRAAQSLYENGYITYMRTDSVTLSHEAIEAAR 345 Query: 337 GYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVN-VMAESLKDMEADAQKLYQLI 394 +S NFG +YL E P QYA+K +QEAHE IRP+ + L + D KLY LI Sbjct: 346 ESVSKNFGSQYLSEKPKQYATKTAGAQEAHECIRPAGSHFRDPSQLATLPPDQLKLYTLI 405 Query: 395 WRQFVACQMTPAKYDSTTLTVGA-----GDFRLKARGRILRFDGWTKVMPA----LRKGD 445 W++ +A QM A + T A G+ ++ G ++ F G+ +V +KG+ Sbjct: 406 WQRTLASQMADATGSTATARFAASAGGLGEATFQSSGTVIEFPGFMRVTGERGGSGKKGE 465 Query: 446 EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQ 505 E LP + + L + H T+PPAR++EASLVK LE + IGRPSTYA+IISTI Sbjct: 466 ESASLPPLAESAELPAKSVLADGHETQPPARYTEASLVKTLEAKEIGRPSTYANIISTII 525 Query: 506 DRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD 565 DRGYV R + VT LE F + ++Y FTA MEN LDQ+A+ + L Sbjct: 526 DRGYVYERGRALIPSWLAFAVTRLLETKFPKYVDYQFTADMENGLDQIAHGNETGREWLT 585 Query: 566 HFF----SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG 621 F+ +D + D+A + + + ++ I+ G + +R G +L Sbjct: 586 QFYFGSGADSARSADEAHEGLQRQVAQLGEIDAREINTIPIGDGIHVRVGRYGPYL---- 641 Query: 622 YALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLH 681 + T +L E + D + RKL Sbjct: 642 ---------EDTKDLDAEGNPKRASIPDTIAP----------------DELTVGEARKLI 676 Query: 682 VCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKN 738 G R+ G D G + ++ GRFG Y+A E + Sbjct: 677 A-----------SNAGGPRVLGTD------PATGGTVEVRNGRFGPYVALVAPESAH 716 >UniRef50_O69548 DNA topoisomerase 1 n=28 Tax=Actinomycetales RepID=TOP1_MYCLE Length = 947 Score = 597 bits (1538), Expect = e-169, Method: Composition-based stats. Identities = 283/887 (31%), Positives = 418/887 (47%), Gaps = 124/887 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 + LVIVESP KA+ ++ YLGS Y+V+SS GHIRDLP + + Sbjct: 15 PRRLVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAK-------------- 60 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + R+GV+ ++E Y + P K+ V+ELK L + D +YLATD DREGEAIAW Sbjct: 61 -FKSEPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAW 119 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL + + R+VF+EIT++AI A P EL+ID V+AQ+ RR +DR+ GY VSP Sbjct: 120 HLMQTLK-PRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSP 178 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT-------------- 227 +LWKK+A LSAGRVQSVA R++V+RER+ AF +W++ A Sbjct: 179 VLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFV 238 Query: 228 ----------TPSGEALALQVTHQND---KPFRPVNKEQTQAAVSLLEKARYSVLEREDK 274 +G T + D ++ + L A+ +V E+K Sbjct: 239 ARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEK 298 Query: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNM 334 T +P PF+TSTLQQ A +L F ++TM +AQRLYE GYITYMRTDST LS+ A+N Sbjct: 299 LYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 358 Query: 335 VRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESL--KDMEADAQKLY 391 R +G++Y+ +SP QY K +N+QEAHEAIRP+ +++ D ++Y Sbjct: 359 ARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIY 418 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGA----GDFRLKARGRILRFDGWTKVM-------PA 440 +L+WR+ VA QM A+ + +L + A GR L F G+ K Sbjct: 419 ELVWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAG 478 Query: 441 LRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASI 500 D +R LP + G L +++LTP H T PPAR++EASLVK LE+ GIGRPSTY+SI Sbjct: 479 GEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 538 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 I T+QDRGYV+ + + VT LE++F L++YDFTA ME+ LD++AN + Sbjct: 539 IKTVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQR 598 Query: 561 KAVLDHFF----SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDC-----PTCGRKMGIRTA 611 L++F+ + + ++ + G+ + ++ GR + +R Sbjct: 599 TNWLNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVG 658 Query: 612 STGVFL-----GCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 TG +L G G P + T L P+ L V E A + R P+ G Sbjct: 659 KTGPYLERLLAGDDGELTPQRANLNGT--LTPDELTLEVAEELFATPHEGRVLGVDPETG 716 Query: 667 TAMDSY--------------------------LIDPKRKLHVCGNNPTCDG--------- 691 + + K + P Sbjct: 717 HEIVAKDGRYGPYVTEVLPKHDDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDL 776 Query: 692 -YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA-------CTNEECKNTRKIL 743 E ++ + G E+ + GR+G Y+ T E+ + Sbjct: 777 QTITLEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLD 836 Query: 744 RNGEVAPPKED-------PVPLPELPC-EKSDAYFVLRDGAAGVFLA 782 ++ + P PL EL S +++DG G ++ Sbjct: 837 EALKIYAEPKRAGRQSTSPPPLRELGTDPTSGKPMLIKDGRFGPYVT 883 >UniRef50_Q1UZD4 DNA topoisomerase n=4 Tax=Bacteria RepID=Q1UZD4_PELUB Length = 863 Score = 595 bits (1535), Expect = e-168, Method: Composition-based stats. Identities = 296/893 (33%), Positives = 436/893 (48%), Gaps = 117/893 (13%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LV+VESPAKAKTINKYLG DY+V +S GHIRDLP+ + Sbjct: 2 NLVVVESPAKAKTINKYLGDDYIVLASYGHIRDLPSKNGS-------------------- 41 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 VDP +N++ +EV +K + E+ A+ + I LATD DREGEAIAWH+ Sbjct: 42 ---------VDPENNFKMEWEVDSFSKKYLKEITDAAKISSKIILATDPDREGEAIAWHV 92 Query: 124 REVIGGDD----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 +E + RVVFNEITK A+ P ++ V+A ARR +D +VG+ + Sbjct: 93 KEYLNEKKLIKDKHIERVVFNEITKKAVIHGIENPRQIEPLLVDAYMARRALDYLVGFNI 152 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP+LW K+ SAGRVQSVA++L+ ERE EI+ F PEEFW + ++ +T Sbjct: 153 SPILWTKLPGSKSAGRVQSVALKLITEREHEIELFDPEEFWTLSIQFNDSDKNSILASIT 212 Query: 240 HQNDKP---FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 NDK F NK + A+ ++ +++ + K P PF TSTLQQ +S R Sbjct: 213 QLNDKKIEKFSFKNKAEIDKAMEEVKSKNFNINDISSKVVNRNPSGPFTTSTLQQVSSGR 272 Query: 297 LGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LGFG +TM +AQ+LY+ G ITYMRTD TNLS DA++ R YI + FG +Y+ Sbjct: 273 LGFGASRTMQIAQKLYQGIEIDGETIGLITYMRTDGTNLSTDAIDTFRKYIKNEFGDEYV 332 Query: 349 PESPNQYASKE--NSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTP 405 P++ Y+ K+ N+QEAHEAIRP+D+ +++K + D KLY LIW + ++ QM P Sbjct: 333 PDNAASYSGKKAKNAQEAHEAIRPTDIMRAPDTVKKYLSPDQHKLYDLIWSRALSSQMKP 392 Query: 406 AKYDSTTLTVGAGDF--RLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVE 463 A++D T+T+ + D KA G +++FDG+ KVM +K D++ ILP +NKG + + Sbjct: 393 AQFDRNTITISSDDNGTICKASGSVIKFDGFLKVMKDTKKDDDEDILPEMNKG-PVNIES 451 Query: 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMG 523 L QHFT+PP R+SEASLVK+LE+ GIGRPSTYASIIS I RGY N+RF+ G Sbjct: 452 LLDEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASIISVISTRGYAETINKRFHPTDRG 511 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPE 583 ++++ LE+ F + ++Y+FTA +EN LD + + W VL+ F+ DF Q + ++ Sbjct: 512 KLISAFLEKLFSKYVDYNFTASLENQLDDITTGKEGWIKVLELFWKDFNQNVSDVKEKRT 571 Query: 584 EGGMRPNQMVLTSI------------DCPTCGRK-MGIRTA-STGVFLGCSGYALPPKER 629 + L S+ C C + ++ + G F+GCS Y Sbjct: 572 REVLDLLNDSLGSLIFERDADGNINRQCKLCDSGSLSLKNSFRGGAFIGCSNYP-----D 626 Query: 630 CKTTINLVPEN--------EVLNVLEGEDAETNALRAKRRCPKC---------------- 665 CK T L E + + E+ L+ R P Sbjct: 627 CKFTRPLSKAKAAAQSQLAEPKFIGKHENGNDMYLKNGRFGPYLQYEKIEEIKEKIIIET 686 Query: 666 -----GTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHL 720 D + T D +++ +F + + + ++ L Sbjct: 687 KKKKKTKKKKIEKEDNNLRNVSIPKGITLDSVDLDRAKF-LCSLPKSLGINPENQKDIIL 745 Query: 721 KMGRFGKYMACTNEECKNT-----------RKILRNGEVAPPKEDPVPLPELP-CEKSDA 768 GRFG Y+ C N+ + R I E P + + +L + Sbjct: 746 NSGRFGPYLKCENKSARIENVEEIFSIGLNRAITLIAEAKPGRMSASIIKDLGEHPEDKK 805 Query: 769 YFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQD 821 + G G + K + A + EE + E L + + D Sbjct: 806 PVRVMKGQYGP------YIKYKSLNATIPEEKDPLELNMEEALILIEKRKEYD 852 >UniRef50_P73810 DNA topoisomerase 1 n=13 Tax=cellular organisms RepID=TOP1_SYNY3 Length = 898 Score = 593 bits (1529), Expect = e-168, Method: Composition-based stats. Identities = 256/775 (33%), Positives = 382/775 (49%), Gaps = 78/775 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP KA+TI YL DY V++S+GH+RDLP S + Sbjct: 1 MSK-LVIVESPTKARTIRNYLPQDYRVEASMGHVRDLPASAEEVPAAY------------ 47 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + +GV+ ++ Y + K+KVV EL+ + AD + LATD DREGE+I+ Sbjct: 48 ---KDKSWANLGVNVEDHFSPLYVIPKSKKKVVKELQTALKNADEVILATDEDREGESIS 104 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ R+VF+EIT+ AIR A +++ + V+AQ+ RR +DR+VGY +S Sbjct: 105 WHLLQLLQ-PKVPIKRMVFHEITQEAIRSALENCRDIDENLVHAQETRRILDRLVGYTLS 163 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWKKIA GLSAGRVQSVAVRL+V+RER +AF +W++ A A +T Sbjct: 164 PLLWKKIAWGLSAGRVQSVAVRLIVQRERARRAFKTAGYWDLKAELEQNKNPFQAKLMTL 223 Query: 241 QN------------------DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 DK +++ Q A L ++V+ E+KP KP Sbjct: 224 GGTKLANGSDFDPNTGALLPDKQVVVLDEAQAIALKERLTGKPWAVVNTEEKPGVRKPSP 283 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDN 342 PF TSTLQQ A+ +LG + TM +AQ+LYE GYITYMRTDS +LS AV R + Sbjct: 284 PFTTSTLQQEANRKLGISARDTMRVAQKLYEEGYITYMRTDSVHLSDQAVTAARNCVQQM 343 Query: 343 FGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 +GK+YL P QY +K + +QEAHEAIRP+ + ++ LY+LIW++ VAC Sbjct: 344 YGKEYLSPQPKQYTTKSKGAQEAHEAIRPAGTEFRIPNQTGLKDRELALYELIWKRTVAC 403 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------PALRKGDEDRILPAVNK 455 QM A+ ++ + D +A G+ + F G+ + P +++ ILP + Sbjct: 404 QMADARITQLSVLLKVEDAEFRAAGKRIDFPGYFRAYVEGSDDPDAALENQEVILPPLKV 463 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 GD E+ H T+PPAR++EASLVK LE G+GRPSTYASII TI DRGYV++ ++ Sbjct: 464 GDRPNCREIDTVGHETQPPARYTEASLVKTLESEGVGRPSTYASIIGTIIDRGYVQMRSK 523 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF---SDFT 572 V LE +F +L++ FT++ME LD++A + +W L FF S Sbjct: 524 ALTPTFTAFAVVSLLESHFPDLVDTGFTSRMEQKLDEIAIGKTQWLPYLQGFFLGESGLE 583 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC--SGYALPPKERC 630 Q+ + + + ++ + ++ G ++ + Sbjct: 584 NQVKVRQDQIDPAIAKAIELENLAAK---------VKIGKFGPYIEIPQGEEIITASIPQ 634 Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYL----------------I 674 T + +V +L+ + + + P+ G + + Sbjct: 635 DLTPADLNPEQVAVLLKQKTEGPDKVGIH---PETGEPIFILIGAYGPYVQLGEATEENK 691 Query: 675 DPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYM 729 PKR G P E + + E + G + +GRFG Y+ Sbjct: 692 KPKRTSLPKGVKPE---DVTLEMAVGLLALPRNLGEHPESGKNIKASLGRFGPYV 743 >UniRef50_Q2J4Z1 DNA topoisomerase n=10 Tax=Bacteria RepID=Q2J4Z1_FRASC Length = 1049 Score = 593 bits (1529), Expect = e-167, Method: Composition-based stats. Identities = 285/874 (32%), Positives = 409/874 (46%), Gaps = 118/874 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LVIVESPAKAKTI YLG + V+SS+GHIRDLP S + + Sbjct: 79 GNRLVIVESPAKAKTIAGYLGPGWQVESSIGHIRDLPRSAADVPAA-------------- 124 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +G R+GVD +++E Y V P K+ VS+LK L + A +YLATD DREGEAIAW Sbjct: 125 -HKGKPWARLGVDVDNDFEPLYIVTPDKKPQVSKLKALVKDASELYLATDEDREGEAIAW 183 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL + + R+VF+EIT AI++A + P +++ + VNAQ+ RR +DR+ GY VSP Sbjct: 184 HLLQTLK-PTVPVKRMVFHEITPQAIQRAVDNPRDIDKNLVNAQETRRILDRLYGYEVSP 242 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST--------------- 226 +LWKK+ LSAGRVQSVA R++VERER F E+W ++ Sbjct: 243 VLWKKVMPRLSAGRVQSVATRILVERERARMRFHSAEYWNIEGLFGATVARQAWSGADGT 302 Query: 227 --TTPSGEALALQVTHQNDKPFRP------------------------------VNKEQT 254 + P G +K P +++ Sbjct: 303 PGSGPDGPGAGSIRGDGVEKTPLPATLIALNGNRIATGRDFSPTGQLVSSGVTRLDEATA 362 Query: 255 QAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA 314 ++ L A ++V E KP P PF+TSTLQQ A +L F ++TM +AQRLYE Sbjct: 363 RSLAERLADAAFTVRSVETKPYRRSPYPPFMTSTLQQEAGRKLRFSSQRTMQVAQRLYEN 422 Query: 315 GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSD- 372 GYITYMRTDSTNLS+ A+ R + +G +Y+P P YA K +N+QEAHEAIRP+ Sbjct: 423 GYITYMRTDSTNLSKTALTAARAQAASLYGPEYVPARPRTYAKKVKNAQEAHEAIRPAGD 482 Query: 373 -VNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA-----GDFRLKARG 426 E +++ D+ +LY+LIW++ VA QM A+ S T+ +GA D A G Sbjct: 483 HFRTPGEVRGELDVDSYRLYELIWQRTVASQMADARGTSATIRLGATSSAGEDAEFSASG 542 Query: 427 RILRFDGWTKVM------PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEA 480 +++ F G+ + P D +R LP V +GD LT LTP H T PPARF+EA Sbjct: 543 KVITFPGFLRAYVEGADDPDAELEDRERRLPDVRQGDPLTTRSLTPRGHTTSPPARFTEA 602 Query: 481 SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY 540 SLVK LE+ GIGRPSTYASII TIQDRGYV + + V LE++F L++Y Sbjct: 603 SLVKTLEELGIGRPSTYASIIGTIQDRGYVWKKGSALVPSFVAFAVVGLLEDHFTRLVDY 662 Query: 541 DFTAQMENSLDQVANHEAEWKAVLDHFF-------SDFTQQLDKAEKDPEEGGMRPNQMV 593 FTA ME+ LD +A A L F+ L + G + ++ Sbjct: 663 RFTATMEDDLDDIAAGTAASTDWLTRFYFGTGDGTDPAADGLKHLV-NERLGEIDAREVN 721 Query: 594 LTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAET 653 + G + +R G ++ + R +L P+ ++ G A Sbjct: 722 SIPLGETDDGTLLVVRVGRYGPYVQ------HGERRASVPDDLAPDELTVDKALGLLAAP 775 Query: 654 NALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDG--------YEIEEGEFRIKGYD 705 + R P G + + + + P + R+ Sbjct: 776 SGDRMLGIDPASGATITAKAGRFGPYVTTDTDPPRTSSLLRGMSLETLTLDDAVRLLTLP 835 Query: 706 GPIVECEKCGSEMHLKMGRFGKYM-------ACTNEECKNTRKILR----------NGEV 748 + + G E+ + GR+G Y+ + +E+ T + G Sbjct: 836 RILGAGDD-GEEVTAQNGRYGPYVKKGAESRSLESEDQLFTVTLDEALALLSQPKARGRR 894 Query: 749 APPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLA 782 + P+ S V+R+G G ++ Sbjct: 895 QAAQSPPLRELGTD-PASGKPMVVREGRFGPYVT 927 >UniRef50_D1N8U4 DNA topoisomerase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N8U4_9BACT Length = 841 Score = 592 bits (1527), Expect = e-167, Method: Composition-based stats. Identities = 257/640 (40%), Positives = 350/640 (54%), Gaps = 54/640 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP KA+TI K LG DY + +S+GHIRDLP Sbjct: 1 MSK-LLIVESPTKARTIGKMLGKDYDIFASMGHIRDLPERD------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD +++ Y + VV ELK A+KAD IYLA D DREGEAIA Sbjct: 41 ----------LGVDIANHFAPQYVDTARSKSVVKELKSAAKKADEIYLAPDPDREGEAIA 90 Query: 121 WHLREVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WHL EV+ A + RV F+EIT++AI +A + GE+N++ V+AQQARR +DR+VGY V Sbjct: 91 WHLAEVLNKSTKAPFYRVTFHEITRSAIERAMQEKGEINLNLVDAQQARRVLDRIVGYQV 150 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SPLLW +I +G SAGRVQS A+RLVVERER I AFVPEE+W T SGE ++ Sbjct: 151 SPLLWSRIEKGSSAGRVQSAALRLVVERERAINAFVPEEYWVFSVVFRTESGEEFTSRLF 210 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARY-SVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 N K F+ N E + + ++ +V APF TSTLQQAA+ L Sbjct: 211 KINGKDFKVPNAEAAEQLIRAIQGGSAPAVASVTTAERKRYAQAPFTTSTLQQAANVSLH 270 Query: 299 FGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 + TM AQ+LYE G ITYMRTDS ++++A +I +G Y+P Sbjct: 271 YSATNTMRYAQQLYEGMDIGEGGAVGLITYMRTDSVTIAREAQQAAAEFIRRTYGDAYVP 330 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKY 408 N Y +K +QEAHEAIRP+DV E + ++ KLY LIWR+FVA QMTPA Sbjct: 331 AKFNYYKNKAAAQEAHEAIRPTDVRRTPEQMAAYLDPQQLKLYTLIWRRFVASQMTPAVV 390 Query: 409 DSTTLTVGA-----GDFRLKARGRILRFDGWTKVMPALRKGDEDR----ILPAVNKGDAL 459 + TT+ VG + + + F G +KV + K ++ +L ++ + D L Sbjct: 391 NLTTVDVGVDGSDGNGYTFRTTATVPVFPGHSKVYEDVAKRKDETQEAAVLGSLRERDPL 450 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 L + Q FT+PP R++EASL+KELE+ GIGRPSTYA+I+ TIQDR YV E + Sbjct: 451 ELRKFDKEQKFTEPPPRYTEASLIKELEENGIGRPSTYATILRTIQDRNYVNREQGKLIP 510 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 ++G V D L E L + FTAQME LD++ + W +++ F+S F ++ A+ Sbjct: 511 SELGFSVNDFLVERLPALFDIGFTAQMEKELDEIEEGKVGWTQMMEDFYSKFAPWVEDAK 570 Query: 580 KDPEEGGMRPNQ--MVLTSIDCPTCGRKMGIRTASTGVFL 617 +L ++ G+ +G RT G F Sbjct: 571 NSDAPPAADAEALLKLLENVTFEAPGK-VGRRTYDDGKFF 609 >UniRef50_A4CJB9 DNA topoisomerase n=4 Tax=Bacteria RepID=A4CJB9_9FLAO Length = 820 Score = 586 bits (1510), Expect = e-165, Method: Composition-based stats. Identities = 285/778 (36%), Positives = 400/778 (51%), Gaps = 100/778 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI K+LG D+ V SS GHI DLP+ Sbjct: 1 MAKNLVIVESPAKAKTIEKFLGKDFKVTSSFGHIADLPS--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD ++ Y V K+ +V +LK+LA KA+ I+LA+D DREGEAI+ Sbjct: 40 --------RELGVDVDKDFSPKYVVDKEKKALVKKLKELASKAETIWLASDEDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E + D + R+VFN ITK+AI++A P ++N D VNAQQARR +DR+VGY +S Sbjct: 92 WHLAETLKLDADKTRRIVFNSITKSAIQKAIENPRKINYDLVNAQQARRILDRLVGYELS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKKI GLSAGRVQSVAVRL+VERER I+ F P+ ++V A T +G L ++ Sbjct: 152 PVLWKKIKPGLSAGRVQSVAVRLIVERERAIEEFEPQSSFKVAAEFRTENGATLPAKLNE 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 D + + Q ++ L A ++V + KP P APF TSTLQQ AS +L F Sbjct: 212 SFD------TETEAQEFLAGLANASFAVDSLDTKPAKKSPAAPFTTSTLQQEASRKLYFS 265 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 V +TM +AQRLYEAG ITYMRTDS +LS +A+ + I N+G+KY Q SK Sbjct: 266 VSRTMQVAQRLYEAGLITYMRTDSVSLSGEAIAAAKEEIVGNYGEKYSKVRKFQSKSK-G 324 Query: 361 SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA--G 418 +QEAHEAIRP+D+ + ++ E D +LY+LI + +A QM+ A+ + T + + Sbjct: 325 AQEAHEAIRPTDMGLQRPNV---ERDQARLYELIRMRTLASQMSDAQLERTQVKIRNDRD 381 Query: 419 DFRLKARGRILRFDGWTKVMPALRKGDE----DRILPAVNKGDALTLVELTPAQHFTKPP 474 D A G +++FDG+ KV + ++ D +LPA+ +ALT +T Q FT+PP Sbjct: 382 DRLFSANGEVIKFDGFLKVYLEGKDEEDAEEQDGMLPAMQVDEALTNNYITATQRFTRPP 441 Query: 475 ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV---------------------- 512 R++EASLVK+LE+ GIGRPSTYA ISTIQ+RGYV Sbjct: 442 YRYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEKGTVDGTEREYLQLTLEGGGVKR 501 Query: 513 ---------ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 + + +G IV D L +F +++Y+FTA++E D +A E +W+ V Sbjct: 502 KELSETVGSDKGKLVPTDIGMIVNDFLVSHFANILDYNFTAKVEKDFDDIATGEEDWQDV 561 Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCS--- 620 L F+ DF + D EE R + + D P GR++ +R G + Sbjct: 562 LRDFYKDFHPNV----LDVEENADRASGERVLGTD-PETGRQVAVRLGRFGPMVQIGTAD 616 Query: 621 -----GYALPPKERCKTTINLVPENEVLNVLE---GEDAETNALRAKRRCPKCGTAMDSY 672 +A ++ TI E+ + + + R P Sbjct: 617 EEEKPQFASLLPDQSLATITYDEAMELFKLPRKLGTFEGDEVEANVGRYGPYVRYGKKFV 676 Query: 673 LIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 +D + D E K D PI E + GRFG ++ Sbjct: 677 SLDEGESVFDV------DMERAAELIRAKKKQDAPIASYE--DKPVTKGKGRFGPFIK 726 >UniRef50_A6DJX4 DNA topoisomerase n=2 Tax=Bacteria RepID=A6DJX4_9BACT Length = 897 Score = 585 bits (1507), Expect = e-165, Method: Composition-based stats. Identities = 263/603 (43%), Positives = 358/603 (59%), Gaps = 55/603 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K LVIVESPAKAKTI K LG D+ VK+S GH+RDLP Sbjct: 3 KKNLVIVESPAKAKTIEKILGKDFEVKASFGHVRDLPQ---------------------- 40 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++GVDP +++E Y+V K+KV++ELK A+ ++IYLA D DREGEAIAW Sbjct: 41 -------RKLGVDPDNDFEPEYQVSADKKKVIAELKSSAKNCENIYLAPDPDREGEAIAW 93 Query: 122 HLREVIGG-DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 HL E++ A + RV FNEITK+AI+ AF+K ++++ RV+AQQARR +DR+VGY VS Sbjct: 94 HLYEILKKQSKAEFKRVTFNEITKSAIKSAFDKAHDVDMHRVDAQQARRILDRLVGYKVS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT--PSGEALALQV 238 PLLWK+ AR SAGRVQ+VA+RL+ ERE+ I+AF PEE+W + A ++ ++ Sbjct: 154 PLLWKRNAR--SAGRVQTVALRLICEREKAIRAFTPEEYWSLQAELKNQAADAQSFISKL 211 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 + K N+E + V LE +++ V + E K +P PFITSTLQQAAS+ L Sbjct: 212 DKIDGKKPHIPNEETSSKIVGELEGSQFRVKDIESKDRKKRPAPPFITSTLQQAASSNLR 271 Query: 299 FGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 F +TM +AQ+LYE AG ITYMRTDS ++++A N +++ +G ++ P Sbjct: 272 FSPSRTMSLAQKLYEGRDLGSEGTAGLITYMRTDSVAIAKEAQNAAIDFVNHIYGSEFSP 331 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKY 408 + PN Y SK ++Q HEAIRP+DV + + + D KLY LIW++FVA QM PA Y Sbjct: 332 DKPNFYKSKNSAQGGHEAIRPTDVTRTPKKMAPYLNDDELKLYTLIWKRFVASQMVPALY 391 Query: 409 DSTTLTV------GAGDFRLKARGRILRFDGWTKVMPALRKGD-----EDRILPAVNKGD 457 ++T + ++ K G +L FDG+ KV G +D ILP + +G+ Sbjct: 392 RQDSITFLPENIGMSHEYLFKITGSVLIFDGFMKVYNFSDDGSQDGESKDVILPQLKEGE 451 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L++L P QHFT+PP RFSEA+LVKELE G+GRPSTYASII TIQDR YV + R Sbjct: 452 ICDLLQLIPKQHFTEPPPRFSEATLVKELEANGVGRPSTYASIIRTIQDREYVFKDKGRL 511 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 G D L L FTA ME LD+V + + EW +L F+S F L+ Sbjct: 512 NPSDKGMESCDFLITTLPSLFEVTFTAHMEELLDKVEHGDLEWTKMLGDFYSGFKDWLED 571 Query: 578 AEK 580 A+ Sbjct: 572 AKT 574 Score = 64.3 bits (155), Expect = 2e-08, Method: Composition-based stats. Identities = 13/45 (28%), Positives = 20/45 (44%) Query: 747 EVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRE 791 +A K ++ C K D+ V + G G F A + FPK + Sbjct: 841 GLADAKSGGEEKTDVKCPKCDSPIVKKVGKRGPFYACSGFPKCKN 885 Score = 48.5 bits (114), Expect = 0.001, Method: Composition-based stats. Identities = 15/49 (30%), Positives = 25/49 (51%), Gaps = 1/49 (2%) Query: 698 EFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRN 745 + + G + V+C KC S + K+G+ G + AC+ +CKN L Sbjct: 844 DAKSGGEEKTDVKCPKCDSPIVKKVGKRGPFYACSGFPKCKNLANSLDK 892 Score = 46.2 bits (108), Expect = 0.005, Method: Composition-based stats. Identities = 21/123 (17%), Positives = 41/123 (33%), Gaps = 19/123 (15%) Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWK--AVLDHFFSDFTQQLD 576 K G + D +++F E ++ +F A + A L + +++ Sbjct: 787 PTKRGRMTYD--DKSFYESLSSNF-AN---------KGSLTPRQSAALKKCVGRYKEKIP 834 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 + T + CP C + + G F CSG+ +CK N Sbjct: 835 AELFPEGLADAKSGGEEKTDVKCPKCDSPIVKKVGKRGPFYACSGFP-----KCKNLANS 889 Query: 637 VPE 639 + + Sbjct: 890 LDK 892 Score = 45.1 bits (105), Expect = 0.013, Method: Composition-based stats. Identities = 19/129 (14%), Positives = 38/129 (29%), Gaps = 11/129 (8%) Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPK---- 627 + + E+ E + +T + PT +M S L S +A Sbjct: 759 EEAVIDPEESKEITALLKALSSVTEWNAPTKRGRMTYDDKSFYESLS-SNFANKGSLTPR 817 Query: 628 -----ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHV 682 ++C E+ + + +CPKC + + + + + Sbjct: 818 QSAALKKCVGRYKEKIPAELFPEGLADAKSGGEEKTDVKCPKCDSPIVK-KVGKRGPFYA 876 Query: 683 CGNNPTCDG 691 C P C Sbjct: 877 CSGFPKCKN 885 >UniRef50_C7MGF4 DNA topoisomerase n=5 Tax=Actinobacteridae RepID=C7MGF4_BRAFD Length = 904 Score = 584 bits (1506), Expect = e-165, Method: Composition-based stats. Identities = 276/798 (34%), Positives = 403/798 (50%), Gaps = 104/798 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ LVIVESPAKA+TI +YLG +Y VK+SVGHIRD+P P + Sbjct: 4 GRHLVIVESPAKARTIGRYLGEEYDVKASVGHIRDIPVP---------------RDLPAE 48 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++G + GVD + ++ +Y V P K+K V+ELK+ + AD +YLATD DREGEAIAW Sbjct: 49 MKKGP-YGKFGVDVENGFDPYYIVSPDKKKTVAELKKALKDADTLYLATDEDREGEAIAW 107 Query: 122 HLREVIGGDDA-RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 HL E + + R+VF+EITK+AIR A +++ V+AQ+ RR +DR+VG+ +S Sbjct: 108 HLLETLKPKKSLPVKRMVFHEITKDAIRAALENTRDIDASLVDAQETRRILDRLVGFELS 167 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA------- 233 P+LW+KI LSAGRVQSVA RLVVERERE AFV ++W++ + G Sbjct: 168 PVLWRKIKPSLSAGRVQSVATRLVVERERERMAFVAADYWDITGTFAAEGGADGTQFTAK 227 Query: 234 --------LALQVTHQNDKPFRP-------VNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 +A +D +P + E TQ V +L A +V E KP T Sbjct: 228 IATVDGARVATGSDFADDGTLKPRAKNAAVLTAESTQTLVEVLGDAPATVTALESKPYTR 287 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY 338 +P APF TS+LQQ AS +L G ++ M +AQ LYE GYITYMRTDS LS +A+ R Sbjct: 288 RPAAPFTTSSLQQEASRKLRLGARQAMRVAQSLYENGYITYMRTDSVTLSGEAIRASRAQ 347 Query: 339 ISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSD--VNVMAESLKDMEADAQKLYQLIW 395 ++ +G +++P+ P Y +K + +QEAHEAIRP+ AE + D +LY+LIW Sbjct: 348 AAELYGSQFVPDKPRYYQNKSQAAQEAHEAIRPAGDHFRTPAEVAGQLSGDEFRLYELIW 407 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDF----RLKARGRILRFDGWTKVMPALR-----KGDE 446 ++ +A QM AK ++T+ + + +A G ++ F G+ R K DE Sbjct: 408 KRTIASQMADAKGTTSTVELLLENEGRAATFRAAGTVITFRGFLAAYEEGRDASRYKDDE 467 Query: 447 ----DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 D+ LP + +G L LTP H T PP R++EASLV+ LE RGIGRPSTYAS ++ Sbjct: 468 EKGGDKRLPQMEEGQTLDTRALTPDGHTTTPPPRYTEASLVRALEDRGIGRPSTYASTVA 527 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 T+QDRGYV V LEE+F ++YDFTAQME LD++A + Sbjct: 528 TVQDRGYVLRRGTALVPSWTAFAVVRLLEEHFGPFIDYDFTAQMEQQLDRMAQGDLARSE 587 Query: 563 VLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGY 622 L +F+ + ++ +I+ G + +R G ++ Sbjct: 588 YLKNFY---LSDGTDGPIGLKPMVDDLGEIDARAINSIEIGEGITLRVGRYGAYV----- 639 Query: 623 ALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHV 682 P +E ++EG D + + A D ++ +++ Sbjct: 640 ------------EQFPRDEDGELIEGADPRRANVSDEV-------APDELTVEKAKEML- 679 Query: 683 CGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKI 742 E + + R+ G D + G E+ K GR+G Y+ E + Sbjct: 680 ----------ERAKDDGRVLGTD------PETGHEIVAKDGRYGPYVTEVLPEAQTA--- 720 Query: 743 LRNGEVAPPKEDPVPLPE 760 +G+ P + P P Sbjct: 721 --DGKKVPKSKQPKPRTG 736 >UniRef50_B3DUA2 DNA topoisomerase n=13 Tax=Actinobacteridae RepID=B3DUA2_BIFLD Length = 1028 Score = 582 bits (1500), Expect = e-164, Method: Composition-based stats. Identities = 278/803 (34%), Positives = 387/803 (48%), Gaps = 132/803 (16%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESP KA I YLG Y V +SVGHIRDL + ++ P Sbjct: 1 MATKLVIVESPTKAHKIGDYLGKGYTVMASVGHIRDLA---------------QPSQVPA 45 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 D+ A + GVD ++ +Y V K++ VSELK + AD +YLATD DREGEAIA Sbjct: 46 ADK--AKFGKFGVDVNDGFKPYYIVDGDKKRTVSELKSALKNADELYLATDEDREGEAIA 103 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL + + + R+VF+EITKNAI + N +++ + V+AQ+ RR +DR+ GY +S Sbjct: 104 WHLVQTLK-PEVPVKRMVFHEITKNAINASLNNTRDVDGNMVDAQETRRILDRLYGYELS 162 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP----------- 229 P+LW+K+ GLSAGRVQSVA RL+VERERE AF +W++ A+ + P Sbjct: 163 PVLWRKVGPGLSAGRVQSVATRLIVERERERMAFKRAPYWDIVATLSAPDALGERAEFSA 222 Query: 230 -----SGEALALQVTHQNDKPF---------RPVNKEQTQAAVSLLEKARYSVLEREDKP 275 G+ LA D R +++ A L A ++V+ E KP Sbjct: 223 RMIALGGKRLAGSKDFGADGQLTPDGFAANVRQLDEAGATAVAEALRTADFTVMSMETKP 282 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMV 335 +P PF TSTLQQ A RLG G + M AQ LYE GYITYMRTDS LSQ+A+ Sbjct: 283 YRRRPQPPFTTSTLQQTAGNRLGMGARVVMRAAQSLYENGYITYMRTDSVTLSQEAITAA 342 Query: 336 RGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLYQ 392 R +S +FG K+L P QYA+K +QEAHE IRP+ + D +LY Sbjct: 343 RNAVSYHFGDKFLSAEPKQYATKTAGAQEAHECIRPAGSRFHDPDELASKLPGDQLRLYT 402 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGA------GDFRLKARGRILRFDGWTKVMPALRK--- 443 LIW++ +ACQM A + T+ + A G+ +A G ++ F G+ K RK Sbjct: 403 LIWQRTLACQMADATGSTATVRLSAPAGPTEGEAVFQASGTVIEFPGFMKATGEGRKPKA 462 Query: 444 ---------------------------GDEDRILPAVNKGDALTLVELTPAQHFTKPPAR 476 + + LP ++ G + ++ P H T+PPAR Sbjct: 463 AAPGAGAGSDQAAAAGKTDAKAVRGDASESNTSLPPMSVGQQVEASDIEPDGHETQPPAR 522 Query: 477 FSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE 536 ++EA+LVK LE + IGRPSTYASIISTI DRGYV R + VT LE NF + Sbjct: 523 YTEATLVKTLEAKEIGRPSTYASIISTIMDRGYVYERGRALIPSWLAFSVTKLLETNFPK 582 Query: 537 LMNYDFTAQMENSLDQVANHEAEWKAVLDHFF----SDFTQQLDKAEKDPEEGGMRPNQM 592 L++Y FTA+MEN LD++A+ E + L HF+ + D+A + ++ + ++ Sbjct: 583 LVDYQFTAEMENGLDRIAHGEESGRDWLTHFYFGSGEGAARNADEAHEGLQQQVAQLGEI 642 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 +I+ G + +R G +L +E DAE Sbjct: 643 DARAINTIDIGDGLHVRVGRYGPYL--------------------------EDMEHLDAE 676 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 N RA A D + R D + G R G D Sbjct: 677 GNPKRASLPD---TIAPDELTVAVAR-----------DLIDNHSGGPRELGVD------P 716 Query: 713 KCGSEMHLKMGRFGKYMACTNEE 735 G + ++ GRFG Y+A Sbjct: 717 VSGGTVEVRNGRFGPYVALVPPA 739 >UniRef50_C4FH65 DNA topoisomerase n=1 Tax=Bifidobacterium angulatum DSM 20098 RepID=C4FH65_9BIFI Length = 996 Score = 582 bits (1499), Expect = e-164, Method: Composition-based stats. Identities = 283/887 (31%), Positives = 404/887 (45%), Gaps = 124/887 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LVIVESP KA+ I+ YLG Y V +SVGHIRDL ++ P Sbjct: 4 GSKLVIVESPTKARKISGYLGDGYTVMASVGHIRDLAQP---------------SQVPAA 48 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 D+ + GVD ++ +Y V K K V++LK +KAD +YLATD DREGEAIAW Sbjct: 49 DKEHY--GKFGVDVNDGFKPYYIVGADKRKTVADLKSALKKADELYLATDEDREGEAIAW 106 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL E + R+VF+EITKNAI+Q+ + +++ D V+AQ+ RR +DR+ GY +SP Sbjct: 107 HLVETLK-PKVPVKRMVFHEITKNAIKQSLEQTRDVDADMVDAQETRRILDRLYGYELSP 165 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS----------- 230 +LW+K+ GLSAGRVQSVA RL+VERERE AF +W++ A + Sbjct: 166 VLWRKVGPGLSAGRVQSVATRLIVERERERMAFTRASYWDIVAKLAAANTQGERVGFDAR 225 Query: 231 -----GEALALQVTHQNDKPFRP---------VNKEQTQAAVSLLEKARYSVLEREDKPT 276 G L D P +++ A LE A ++V+ E KP Sbjct: 226 MVSLGGRRLVGSKDFGADGKLTPAGFADNVCQLSQTDAAAVAQELEHAPFTVMSMESKPY 285 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 +P PF TSTLQQ A RLG + TM AQ LYE GYITYMRTDS LS +A+ R Sbjct: 286 RRRPLPPFTTSTLQQTAGNRLGMSSRATMRAAQGLYENGYITYMRTDSVTLSSEAIAAAR 345 Query: 337 GYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLYQL 393 + +FGK +L ++P QY +K +QEAHE IRP+ + +D KLY L Sbjct: 346 NAVEYHFGKSFLSDAPKQYDTKTAGAQEAHECIRPAGARFHDPDELATRVPSDQLKLYTL 405 Query: 394 IWRQFVACQMTPAKYDSTTLTVGA-----GDFRLKARGRILRFDGWTKVMPAL------- 441 IW++ +A QM A + T+ + A G+ +A G ++ F G+ K Sbjct: 406 IWQRTLASQMADATGSTATVKISAPAGGHGEALFQASGTVIDFPGFMKATGEQHHAAKQG 465 Query: 442 ----RKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTY 497 + + LP ++ G L + ++ H T+PPAR++EASLVK LE + IGRPSTY Sbjct: 466 GRKGENAEGNASLPPMSAGQRLDVADVQADGHETQPPARYTEASLVKTLEAKEIGRPSTY 525 Query: 498 ASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHE 557 ASIISTI DRGYV R + V LE F +L++Y FTA MEN LDQ+A+ + Sbjct: 526 ASIISTIIDRGYVYERGRALIPSWLAFAVVKLLETKFPKLVDYQFTADMENGLDQIAHGK 585 Query: 558 AEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP----NQMVLTSIDCPTCGRKMGIRTAST 613 + L F+ + EG R ++ +I+ G + +R Sbjct: 586 QTGRDWLTRFYFGDGDAAAANADEAHEGLQRQVAQLGEIDARAINTIEIGDGLHVRVGRY 645 Query: 614 GVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETN---ALRAKRRCPKCGTAMD 670 G +L + + + + L V D N R + PK G ++ Sbjct: 646 GPYLEDMAHTDEDGNPKRAALPDTIAPDELTVDVARDLIENHSGGPRELGKDPKTGGTVE 705 Query: 671 SYLIDPK----------------RKLHVCGNNPTCDGYEIE----------EGEFRIKGY 704 K + P + + R+ Sbjct: 706 VRNGRFGPYVALLPVEGAVSPAPAKGSKKSDAPRPKMASLFKTMSPESITLDDALRLLSL 765 Query: 705 DGPIVECEKCGSE--------MHLKMGRFGKYMACTNEE-CKNTRKILRNGEV------- 748 + E+ +E + GR+G Y+ T + TR + E+ Sbjct: 766 PREVGSYEEANAETGEISTSTVAANNGRYGPYLTKTKADGSTETRSLNSEDEIFTVDIET 825 Query: 749 -----APPKEDP-------VPLPELPC-EKSDAYFVLRDGAAGVFLA 782 A PK P+ EL +S V+R+G G++L Sbjct: 826 AKALFAQPKFRGRGRGAAKPPIRELGTDPESKKPVVIREGRFGMYLT 872 >UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2_CLAMS Length = 1012 Score = 581 bits (1498), Expect = e-164, Method: Composition-based stats. Identities = 251/650 (38%), Positives = 344/650 (52%), Gaps = 57/650 (8%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESPAKAKTI +YLGS Y V++SVGHIRDL + + T K + Sbjct: 47 KKLVIVESPAKAKTIAQYLGSGYEVQASVGHIRDLIEPKNLPPELKKGTLGKFS------ 100 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 VD + +E +Y V K+K V++LK+ + AD ++LATD DREGEAIAWH Sbjct: 101 ----------VDVENGFEPYYVVSDQKKKTVADLKRALKDADELFLATDEDREGEAIAWH 150 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L +V+ R+VF+EITK AI +A + +++ V+AQ+ RR +DR+ GY VSP+ Sbjct: 151 LLQVLK-PKVPVKRMVFHEITKEAIERARDSTRDIDTALVDAQETRRILDRLYGYEVSPV 209 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST---------------- 226 LW+K+ GLSAGRVQS A RLVV+RERE AFV +W++ AS Sbjct: 210 LWRKVGPGLSAGRVQSAATRLVVDRERERLAFVTASYWDLTASLSPLEQELPFDARLVRI 269 Query: 227 ---TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 +G + +ND + + A V E KP T +P AP Sbjct: 270 DGARIATGRDFDDKGALKNDSRPLDASSAEALAEALRDPSVPLKVQSVESKPYTRRPAAP 329 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNF 343 F TSTLQQ A+ +L F ++TM +AQ LYE GYITYMRTDS +LSQ A+N R ++ + Sbjct: 330 FTTSTLQQEAARKLRFSARQTMSVAQSLYENGYITYMRTDSPSLSQQAINAARKQAAELY 389 Query: 344 GKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLYQLIWRQFVA 400 G + +P+ P YA K +N+QEAHEA+RP+ + + KLY LIW++ +A Sbjct: 390 GPETVPDKPRLYAGKSKNAQEAHEAVRPAGETFRTPQQLASTLRGNDHKLYDLIWKRTIA 449 Query: 401 CQMTPAKYDSTTLTVGAGD------FRLKARGRILRFDGWTKVMPALRKGDE-------D 447 QM AK + ++ + AG A G ++ F G+ R + + Sbjct: 450 SQMADAKGSTASVVIAAGPTSAGEVAEFAASGTVITFRGFLAAYEESRDEERHGAAEPRE 509 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 LP + KG L LV++ H T PP R++EASLVK LE+ GIGRPSTYA+IISTI DR Sbjct: 510 AKLPDLKKGQDLRLVDVDAKGHETSPPPRYTEASLVKTLEELGIGRPSTYAAIISTIVDR 569 Query: 508 GYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 GYV + V LEE F EL+ YDFTA ME+ LD++A AE L F Sbjct: 570 GYVTPRGTALVPNWIAFSVVRLLEEFFTELVQYDFTAGMEDDLDRIAEGAAERVDWLKGF 629 Query: 568 FSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL 617 + + A K ++ I+ + +R G +L Sbjct: 630 YYG-----NDAHKGLRPTIDNLGEIDAKEINSLRIADDITLRIGKYGPYL 674 >UniRef50_Q83FM2 DNA topoisomerase n=2 Tax=Tropheryma whipplei RepID=Q83FM2_TROWT Length = 841 Score = 580 bits (1496), Expect = e-164, Method: Composition-based stats. Identities = 270/779 (34%), Positives = 394/779 (50%), Gaps = 67/779 (8%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESP K ++ +YLG YVV SSVGHIRDLP D Sbjct: 2 KKLVIVESPTKVSSVGRYLGDGYVVMSSVGHIRDLPAPSGLTP----------------D 45 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + + + V+ +++E +Y VL K+KVV EL+ +D + +ATD DREGEAIAWH Sbjct: 46 LKRSAHAQFAVNIENDFEPYYVVLENKKKVVEELQSALNNSDELLIATDGDREGEAIAWH 105 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L +V+ R+VF+EIT+ AI A P ++ + V+AQ+ARR +DR+ GY +SP+ Sbjct: 106 LVQVLK-PTVPVRRLVFHEITREAIAYALQHPRPIDENLVDAQEARRILDRLYGYELSPV 164 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LWKK+ GLSAGRVQS A RL+V+RERE F E+ V A S + + +T Sbjct: 165 LWKKVRPGLSAGRVQSPATRLLVDRERERINFKSAEYQAVTADFQVDS-DVFSASLTLFG 223 Query: 243 DKPFR----------------PVNKEQTQAAVSLLE-KARYSVLEREDKPTTSKPGAPFI 285 ++ ++K T + L+ K V + KP + P APFI Sbjct: 224 ERKIATGRDFDNLANLKTDALVLDKNLTDRILEELKSKGALDVEAIDSKPYSRNPYAPFI 283 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 TSTLQQ A+ +LGF K+TM AQ+LYE G+ITYMRTDS LS A++ R + +G+ Sbjct: 284 TSTLQQDAAHKLGFSAKRTMRTAQQLYEKGFITYMRTDSPRLSLQAISAARAQVELLYGR 343 Query: 346 KYLPESPNQYASK-ENSQEAHEAIRPSD-VNVMAESLKD-MEADAQKLYQLIWRQFVACQ 402 ++LP+SP Y +K +N+QEAHEAIRP+ V ES++ + D +LY LIWR+ +A Q Sbjct: 344 EFLPDSPRTYGAKAKNAQEAHEAIRPTGEVFERPESIESVLSVDCMRLYDLIWRRTIASQ 403 Query: 403 MTPAKYDSTTLTVGA---GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 M A+ ++ TLT+ A G +L G+ KV L+ + ++LP + GD + Sbjct: 404 MVSARGETVTLTLSARIPERSIFVLSGTVLHEKGFLKVYEGLQDLNS-KLLPNLQVGDQV 462 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 TLV++ H T PP R++EASLVK LE+ G+GRPSTYA I+STIQ+RGY + NR Sbjct: 463 TLVDVRAVGHTTLPPPRYTEASLVKVLEELGLGRPSTYALILSTIQERGYAHLRNRMLVP 522 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 + + V + LE F L++YDFTA +E+ LD++A L F+ F D Sbjct: 523 DWLAFSVVNLLENFFSRLIDYDFTANLEDQLDEIALGSQNRSDWLRKFY--FGD--DNLP 578 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL--GCSGYALP--------PKER 629 E + P G + R G +L G +++P E+ Sbjct: 579 GLKEIISGAKDIDARAINSIPMVGATL--RVGRYGPYLEVGDKRFSIPHDVYPDALTPEK 636 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 +N E + L++ R P S + +R +P Sbjct: 637 IHELVNQPESPVRELGAHPETGKLVVLKSGRFGPY--IEEVSDEKNVRRSSLFKNMDPE- 693 Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEV 748 + ++ I ++ G ++ GRFG Y+ C K TR + ++ Sbjct: 694 --EVNLDVAVKLLEIPRVIGVNQENGEKVIACNGRFGPYIKCG----KETRPLDSEDDI 746 >UniRef50_C0W593 DNA topoisomerase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W593_9ACTO Length = 931 Score = 580 bits (1495), Expect = e-164, Method: Composition-based stats. Identities = 292/896 (32%), Positives = 414/896 (46%), Gaps = 138/896 (15%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP K ++I YLGSD+ V++SVGHIRDL Sbjct: 1 MSKKLVIVESPNKVRSIAGYLGSDFDVEASVGHIRDLAQPSELPAA-------------- 46 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 E+ + VD H ++ +Y V P K+K V++LK+ + AD +YLATD DREGEAIA Sbjct: 47 --EKKGPYGKFAVDVEHGFKPYYVVNPDKKKTVAQLKKALKDADELYLATDDDREGEAIA 104 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL EV+ R+ F EITK A+ +A EL+ DRV+AQ+ RR +DR+VGY VS Sbjct: 105 WHLLEVLK-PKVPVKRMTFTEITKEAVTRALESTRELDTDRVDAQETRRILDRLVGYEVS 163 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS---------- 230 P+LW+K+ GLSAGRVQSVA RLVVERERE AF +W V+A T Sbjct: 164 PVLWRKVRAGLSAGRVQSVATRLVVERERERMAFKAAGYWGVEAELGTTGSLEESGRTFT 223 Query: 231 -------GEALALQVTHQNDKPFRP---------VNKEQTQAAVSLLEKARYSVLEREDK 274 G +A +D RP +++ +A + + +V E E K Sbjct: 224 ARLATLDGRRVATGRDFGDDGALRPAAVKAHTVHLHEGGARAVADAVMASAPTVTEMETK 283 Query: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNM 334 P +P APF TSTLQQ AS +L ++TM +AQ LYE GYITYMRTDST LS AV Sbjct: 284 PYKRRPAAPFTTSTLQQEASRKLRMNPRETMRVAQGLYENGYITYMRTDSTVLSGQAVAA 343 Query: 335 VRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLY 391 R +++ +G +Y+P P YA+K + +QEAHEAIRP+ + + + +LY Sbjct: 344 ARAQVAELYGAQYVPAKPRLYATKTKGAQEAHEAIRPAGDHFRTPAQVAGALSGAQFRLY 403 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGA------GDFR----------LKARGRILRFDGWT 435 +LIW++ VA QM A + T+ V G R A G ++ F G+ Sbjct: 404 ELIWKRTVASQMADAVGQTATVKVEVPLKEAKGGARDSGVTFRTAGFTASGTVITFRGFL 463 Query: 436 KVMPALRKGDE--------------DRILPAVNKGDALTLVELTPAQHFTKPPARFSEAS 481 R + + LPA+ GD L + H T PP R++EAS Sbjct: 464 AAYEEGRDAERYEAEPGKAGAASAGEVRLPAMEVGDVLDAKVAEASGHETTPPPRYTEAS 523 Query: 482 LVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYD 541 LVK LE+R IGRPSTYA+ +STI DRGYV + + VT LEENF EL++YD Sbjct: 524 LVKALEEREIGRPSTYAATMSTIADRGYVEHRGQALVPTWLAFAVTRLLEENFSELVDYD 583 Query: 542 FTAQMENSLDQVANHEAEWKAVLDHF-FSDFTQQLDKAEKDPEEGGM----RPNQMVLTS 596 FTA ME LD++A E + A L F + D Q + + PE+G ++ + Sbjct: 584 FTASMEADLDRIAAGEEDRVAWLTRFYYGDGDGQGAQPGEGPEQGLKAMLDNLGEIDARA 643 Query: 597 IDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEN-EVLNVLEGEDAETNA 655 ++ G + +R G +L +R ++ P+ V E + + Sbjct: 644 VNSIEIGEGITLRVGRYGPYL-----EDEEGKRANVPADVAPDELTVAKAKELFERAADD 698 Query: 656 LRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC- 714 R P G + + D + +V P +G + + E K K Sbjct: 699 GRELGVDPSTGHVIIA--KDGRYGPYVTEVLPEPEGTQEPQDEAAPKKRTSKAKTGPKPR 756 Query: 715 ---------------------------------GSEMHLKMGRFGKYM-------ACTNE 734 G ++ + GR+G Y+ + +E Sbjct: 757 TASLFKSMGLSTVTLEQALDLLSLPRVVGQDAEGVDITAQNGRYGPYLKKGTDSRSLESE 816 Query: 735 ECKNTRKILRNGEV--APPKEDPVPLPELPC------EKSDAYFVLRDGAAGVFLA 782 E T + + E+ P + P+ P S V++DG G + Sbjct: 817 EQLFTVTLEQALEIFAQPKRRRGQAAPKAPLRELGTDPVSGRPVVIKDGRFGPYFT 872 >UniRef50_C1E9E3 DNA topoisomerase n=1 Tax=Micromonas sp. RCC299 RepID=C1E9E3_9CHLO Length = 1227 Score = 578 bits (1491), Expect = e-163, Method: Composition-based stats. Identities = 272/872 (31%), Positives = 411/872 (47%), Gaps = 139/872 (15%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LV+VESPAKA ++ KYLG Y V +S GH+RDL Sbjct: 135 KLVVVESPAKATSVQKYLGDGYTVLASYGHVRDLVQKNG--------------------- 173 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 GV P ++ + ++ VV ++ + A+ A + LATD DREGEAI+WH+ Sbjct: 174 --------GVKPEDDFAMLW-AEKARDGVVRDIVKNAKGAAELLLATDPDREGEAISWHI 224 Query: 124 REVIGGDDA-------RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 E++ RV F E+TK A+R+AF P E++ V+A ARR +D + G Sbjct: 225 VELLREKGVLGSSSSLPVKRVTFTEVTKKAVREAFESPREISAPLVDAYLARRALDYLFG 284 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST--TTPSGEAL 234 + +SP+LW+K+ LSAGRVQS A+RLV ERE EI+ FV EEFW V A SG + Sbjct: 285 FTLSPVLWRKMPGALSAGRVQSAALRLVCEREFEIERFVKEEFWNVFAGLEPDGSSGRSF 344 Query: 235 ALQVTHQNDKPFRPVN-----KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTL 289 ++TH + K + + A L + +V + +K + +P PF TSTL Sbjct: 345 VGELTHLDGKRLGKMEPGSREAAELAARAVLSASSTLAVHDVVEKDVSRRPRPPFTTSTL 404 Query: 290 QQAASTRLGFGVKKTMMMAQRLYEA-----GYITYMRTDSTNLSQDAVNMVRGYISDNFG 344 QQ AS+RLGFG +TM AQ LYE G ITYMRTD ++S AV +R FG Sbjct: 405 QQDASSRLGFGAARTMAAAQSLYEGRGWGEGLITYMRTDGLHVSPAAVAELRDVAGAEFG 464 Query: 345 KKYLPESPNQYAS-KENSQEAHEAIRPSDVNVMAESLKD---MEADAQKLYQLIWRQFVA 400 ++Y+PE PN + ++N+QEAHEAIRP+ ++ +++ + +D +LY+LIW + +A Sbjct: 465 EEYVPEKPNFFRKVQKNAQEAHEAIRPTKAGILPQAVANRLGSGSDEARLYRLIWARTMA 524 Query: 401 CQMTPAKYDSTTLTVGAGDF--RLKARGRILRFDGWTKVMP--------ALRKGDEDRIL 450 QM+ A V + D RLKA G L F G+ + GD DR L Sbjct: 525 SQMSAAVTKRVQADVWSEDERLRLKATGSRLIFPGYLAAYKHGMRDGDDSTSFGDNDRWL 584 Query: 451 PAVNKGDALTLV---------------------------------------ELTPAQHFT 471 P ++ G+ + ++ +T QH+T Sbjct: 585 PRLDVGEKIRVIGDEVKIVERDKDAKRGGFKKADADDDGEHEIDTTAGKDTGVTATQHWT 644 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR--FYAEKMGEIVTDR 529 +PP R++E SLVK LE++GIGRPSTYA+I+ I+ RGYV E+ R E G +V+ Sbjct: 645 QPPGRYTEGSLVKALEEKGIGRPSTYATIMKVIKRRGYVAGESGRGPLIPETRGRLVSSF 704 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 L F E ++Y FTA +E+ LD +A+ + +WK+VL F+ F ++ + G+R Sbjct: 705 LAHFFDEYVDYGFTAGLEDRLDDIASGKEDWKSVLSGFWGPFAGDVESLK------GIRT 758 Query: 590 NQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE 649 +Q V+ +D G +S L A + P Sbjct: 759 SQ-VVDVLDATLGAHFFGDDESSVDARLSAIERAAEEAATQAESTGGYPTVAF------- 810 Query: 650 DAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE--IEEGEFRIKGYDGP 707 + L + RRCP CGT + C N P+C + +G+ + G + P Sbjct: 811 --DPEELSSTRRCPGCGTGRLGLKLSRTGGFIGCSNYPSCGHTRQLVNDGDGAVGGGNFP 868 Query: 708 IVEC--EKCGSEMHLKMGRFGKY----MACTNEECKNTRKI---LRNGEVAPPKED---- 754 I + G ++ ++ G +G Y M + ++ K T+ L+N + P D Sbjct: 869 IELGTDPESGGDVAIQNGPYGPYIELQMPSSPDDSKKTKPQRFGLKNIGLKPEDVDMDLA 928 Query: 755 ----PVPLPELPCEKSDAYFVLRDGAAGVFLA 782 P+ P + V+ G G +++ Sbjct: 929 MTLLRYPMVLGPHPEDGKDVVMNMGPFGWYVS 960 >UniRef50_A8F3N1 DNA topoisomerase n=2 Tax=Thermotogaceae RepID=A8F3N1_THELT Length = 722 Score = 577 bits (1488), Expect = e-163, Method: Composition-based stats. Identities = 252/803 (31%), Positives = 407/803 (50%), Gaps = 99/803 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M ++IVESPAKAKTI + L +Y V SS GH+RDLP Sbjct: 1 MANKIIIVESPAKAKTIKEILKGEYDVLSSKGHVRDLPE--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 GV+ ++E ++++ GKEK+V ELK+ A+ + L +D+DREGEAIA Sbjct: 40 --------KEFGVNIEKDFEPTFKIIYGKEKIVQELKKKAKN-KQVLLGSDMDREGEAIA 90 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++G + + +R++FNEIT AI+ A +P +++++V+AQ ARR +DR+VGY +S Sbjct: 91 WHLADILGVANEK-NRIIFNEITPQAIKNAVKEPRNIDMNKVHAQLARRILDRIVGYKIS 149 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWK + SAGRVQS A+++V ERE + F P++FW+V + L +TH Sbjct: 150 PLLWKMLKTSSSAGRVQSAALKIVCEREIQRHKFQPKKFWKVQGYIGS-----LKFYLTH 204 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + K ++ A V++ + + K +PFITSTLQQ A+ +LGF Sbjct: 205 IDGKKIDMQQIDEKLAKEIEKNVKVLKVIQIKTRKIQKKAPSPFITSTLQQEAANKLGFS 264 Query: 301 VKKTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 VKKTM +AQ+LYE +ITYMRTDST +S+ A +I+D FGK YL + Sbjct: 265 VKKTMQIAQQLYEGIDTPKGHRAFITYMRTDSTRVSEIAKQKAIEFITDKFGKNYLGKKV 324 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTPAKYDST 411 +K+N Q+AHEAIRP ++++ + ++ D+ D +LY+LIW +F+A QM A Y+ T Sbjct: 325 RTEKAKQNVQDAHEAIRPVNIDLTPDQVEGDLGKDQYRLYKLIWERFMASQMADAIYEET 384 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 T+ + + +++ FDG+ ++ + +++ +P+ G+ + + + + T Sbjct: 385 TIQFQSDRYTFESKIERRIFDGFEIILK--KDKEQEITIPS---GE-IRISKWQIEEDET 438 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPPAR++EAS+V+ LE RGIGRPSTYA+IIST+ +R YV + + MG +V LE Sbjct: 439 KPPARYTEASMVRALEIRGIGRPSTYATIISTLLERKYVIKSSNQLIPTVMGFVVNHYLE 498 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 + F E+++ FTA+ME +LD++ + ++K +L F++DF++ LD+A++ M N Sbjct: 499 KKFPEIVDLQFTAKMEEALDKIEQGQKDYKELLRDFYNDFSKYLDEAQQKWLSIDMNTNL 558 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 C K ++ G++L C C T +L E + Sbjct: 559 E-------CDCKSKYKLKVGRYGLYLLCEN--------CSKTTSLALETPAVFYENTMYF 603 Query: 652 ETNALRAKRR-CPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710 + CP CG ++ GN C F + Sbjct: 604 THQEKESIETVCPVCGGKLEQMSGRY-------GNYIKCQNCGKTYTGFARG-------K 649 Query: 711 CEKCGSEMHLKMGRFGK-YMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C KC + + K+ + + + CT++ C + + E C + Sbjct: 650 CPKCSAVVEKKISKNKRIFFKCTSDNCDFISWLEPSNE--------------TCPECSQR 695 Query: 770 FVLRDGAAGVFLAANTFPKSRET 792 + + L ++T Sbjct: 696 LYYKKYRSKEVLYCQN---CKKT 715 >UniRef50_C6V581 DNA topoisomerase n=2 Tax=Neorickettsia RepID=C6V581_NEORI Length = 827 Score = 573 bits (1478), Expect = e-162, Method: Composition-based stats. Identities = 270/828 (32%), Positives = 423/828 (51%), Gaps = 96/828 (11%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 ++IVESP K K I +YLG D+ V SS GH+R LP Sbjct: 2 NVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPN------------------------ 37 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 + VD ++E Y++ E VV +L + + A +YLATD DREGEAI+WHL Sbjct: 38 -----KKGSVDVTDSFEMLYKLTDTGETVVPQLIKDVKNATALYLATDPDREGEAISWHL 92 Query: 124 REVIGGDD---ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 EV +D RVVF+EITK A++ A P +++ + V AQ+ R+ +D +VG+ +S Sbjct: 93 VEVFKENDVLPKNVHRVVFHEITKTAVQNAIASPRKIDENLVRAQRLRQALDYLVGFSIS 152 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ SAGRVQSVA+R++ +RE EI F PEE+W V + T G + Q++H Sbjct: 153 PVLWKKLPGSKSAGRVQSVALRILCDRENEIGLFTPEEYWIVSVNMTDGEGLVIPTQLSH 212 Query: 241 QNDKPFRPVN---KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 N + ++ E+ + V + + + V E + K KP PFITST+QQ AST L Sbjct: 213 INGEKLERMSIRGAEEAEKIVEEIRELPFLVEEIKKKELKQKPSPPFITSTMQQTASTVL 272 Query: 298 GFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 GF VKKTM +AQ+LYE G ITYMRTD+T+LS ++V+ +R +I FG++YLP Sbjct: 273 GFSVKKTMSLAQKLYEGIEIGGAIEGLITYMRTDATHLSVESVDAIREFIQKKFGQEYLP 332 Query: 350 ESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 ESP + K +N+QEAHEAIRP+ + E ++ + D KLY+LIW + +ACQM+ A Sbjct: 333 ESPVLFKKKVKNAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWERALACQMSDAI 392 Query: 408 YDSTTLTVGAGDFRLK--ARGRILRFDGWTKVMPALRKGDEDR----ILPAVNKGDALTL 461 S + + D + K A +L FDG+ + ++++ + +G + + Sbjct: 393 TSSQNIVFISQDEKFKTSASASLLIFDGFNAAFSHGKNKNKNQGVIDFIKKHKEGAQVKV 452 Query: 462 VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521 ++ P Q+FT+PP R+SEA LVK LE+ GIGRPSTYA+++S +Q+RGY + N+ F E Sbjct: 453 GDVLPTQNFTEPPHRYSEAGLVKHLEELGIGRPSTYATVVSVLQERGYASIVNKSFIPEN 512 Query: 522 MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 G +V++ L F + + Y FTA+ME+ LD+VA+ W V+ F+ F +++ EK Sbjct: 513 RGRLVSEFLVHFFSKYVEYHFTAEMEDRLDKVADGTIFWLDVIQDFWDSFHSNVEEVEKV 572 Query: 582 PEE------GGMRPNQMVLTSI-----DCPTCGRK-MGIRTASTGVFLGCSGYALPPKER 629 P G Q ++++ CP C + M + + GVFLGC+ Y + Sbjct: 573 PITEVLAFVNGALAKQKLVSAEVKVGDKCPKCEKGYMHLSVSRYGVFLGCTNYPV----- 627 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 C+ +N ++ + + + + P G + K ++ Sbjct: 628 CRFIVNSYSTDDDTEYPK----QIAQDISLHKGPY-GIYL---------KYKGKNSSIPK 673 Query: 690 DGYEI---EEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNG 746 D + EE +I + + G E+ + +G +G Y+ + + + Sbjct: 674 DVDPVSIDEEFAHKIASLPKILGKHPADGKEIKMGLGPYGLYLFWNAKY--YNLQFSQMD 731 Query: 747 EVAPPKEDPVPLPELPCEKS---------DAYFVLRDGAAGVFLAANT 785 E+ K + +KS +RDG G ++ + Sbjct: 732 EMTLDKAVQFIQSYVIHDKSLLRVLGSYEGEEIQIRDGRYGPYIKCSK 779 Score = 43.9 bits (102), Expect = 0.026, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 12/32 (37%), Gaps = 1/32 (3%) Query: 762 PCEKSD-AYFVLRDGAAGVFLAANTFPKSRET 792 C K + Y L GVFL +P R Sbjct: 600 KCPKCEKGYMHLSVSRYGVFLGCTNYPVCRFI 631 >UniRef50_Q6XZ01 DNA topoisomerase n=2 Tax=Spiroplasma RepID=Q6XZ01_SPIKU Length = 664 Score = 572 bits (1473), Expect = e-161, Method: Composition-based stats. Identities = 251/708 (35%), Positives = 381/708 (53%), Gaps = 75/708 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVI+ESP K K + KYLG +Y+V SS GHIR+L T G Sbjct: 1 MAQTLVIMESPTKTKAVEKYLGENYLVLSSEGHIRNLSTKGQYG---------------- 44 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD +E Y++ GK++++ +LKQ A+ AD I LATD DREGEAIA Sbjct: 45 ----------LGVDI-KTFEPSYKMERGKKEIIKKLKQEAKAADLIILATDPDREGEAIA 93 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +HL EV+ + RV FNEITK A+ +AF +L+++ V++Q+ RR +DR +G+ +S Sbjct: 94 YHLNEVLNCGEKS-RRVRFNEITKEAVLEAFQHQTDLDMNLVHSQETRRILDRFIGFRLS 152 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 LL KKI + SAGRVQSVA++LVVERE+E + FVPEE+W V+ +++T Sbjct: 153 KLLQKKI-KSKSAGRVQSVALKLVVEREKEWQNFVPEEYWTVEGLYKKA-----VVKLTK 206 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 D + E V K + V++ ++ K P TST+ Q AS+++GF Sbjct: 207 FKDYKIE-LKVEADVLKVKKALKKDFVVVQIKESEKQRKSPNPHTTSTMLQEASSKMGFA 265 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KT ++AQ+LYE G+ITY RTDS LS V YI+ +G +YL Sbjct: 266 SNKTSLIAQQLYEGIKVKDNITGFITYPRTDSIRLSDKFVQDAFDYITIKYGTEYLGGVK 325 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 Q +K+N Q+AHEAIRP+D+ + E+ K+ + D +LY++I+ + +A M AK S Sbjct: 326 TQPKNKKNVQDAHEAIRPTDLTMTPEAAKEYLSRDQIRLYKIIYNRSLASLMANAKLLSK 385 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + + ++ + G ++FDG+ K L +E LP + + L EL QHFT Sbjct: 386 AIILDNNNYEFRMTGSTIQFDGFLKCY-FLEGNEEIVKLPMLKPNQIINLNELYGIQHFT 444 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPP+ +SEA L+K LE+ G+GRPSTYA I+ T++DRGY+ VEN+ A + G + +D+L+ Sbjct: 445 KPPSHYSEAKLIKTLEEIGVGRPSTYAPIMQTLKDRGYIIVENKAIKATEKGILTSDKLQ 504 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 E F +++N +T+ +E SLD +A+ +AE K +L F+ F +++ + EE + Sbjct: 505 EYFSDIINETYTSTIEKSLDMIAHGDAEPKPLLKEFWERFEPRIEATMELMEEIPVEK-- 562 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 + I+CP CG + R G F+ CSG+ +C P+ Sbjct: 563 ---SGIECPECGNDLVYRYGKYGKFIACSGFP-----KCHYIHQTGPKFG---------- 604 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKR-KLHVCGNNPTCDGYEIEEGE 698 CP+CG + +R + C N P C+ + + E Sbjct: 605 ---------PCPECGVGEIILKFNKRRQRFKACTNYPNCNYTDSYKEE 643 Score = 67.4 bits (163), Expect = 2e-09, Method: Composition-based stats. Identities = 19/96 (19%), Positives = 38/96 (39%), Gaps = 17/96 (17%) Query: 702 KGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPE 760 + +EC +CG+++ + G++GK++AC+ +C I + G P Sbjct: 558 IPVEKSGIECPECGNDLVYRYGKYGKFIACSGFPKCHY---IHQTGPKFGP--------- 605 Query: 761 LPCEKSD-AYFVLRDGAAG-VFLAANTFPKSRETRA 794 C + +L+ F A +P T + Sbjct: 606 --CPECGVGEIILKFNKRRQRFKACTNYPNCNYTDS 639 Score = 59.0 bits (141), Expect = 8e-07, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 19/47 (40%) Query: 752 KEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVE 798 +E PV + C + V R G G F+A + FPK + Sbjct: 556 EEIPVEKSGIECPECGNDLVYRYGKYGKFIACSGFPKCHYIHQTGPK 602 >UniRef50_C6XXX5 DNA topoisomerase n=76 Tax=Bacteria RepID=C6XXX5_PEDHD Length = 857 Score = 569 bits (1467), Expect = e-160, Method: Composition-based stats. Identities = 285/784 (36%), Positives = 412/784 (52%), Gaps = 109/784 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKAKTI YLG D++VKSS GHIRDL Sbjct: 1 MAKNLLIVESPAKAKTIEGYLGKDFLVKSSYGHIRDLVKGD------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 M +D +N+ YEV K++VV+ELK+LA+ A+ ++LA+D DREGEAI+ Sbjct: 42 ----------MAIDTANNFAQTYEVPSDKKQVVAELKKLAKDAEMVWLASDEDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E +G + + R+VF+EITK AI +A P ++ + VNAQQARR +DR+VG+ +S Sbjct: 92 WHLYETLGLKENKTKRIVFHEITKPAILKAIETPRSIDYNLVNAQQARRVLDRLVGFELS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKKI LSAGRVQSVAVRL+V+RERE+ F +++ A T +G+ L Sbjct: 152 PVLWKKIKPSLSAGRVQSVAVRLIVDREREVNKFNAAAAFKITAEFVTGNGKELV----- 206 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + P R + + ++ A +SV E KP P APF TSTLQQ AS +LG+ Sbjct: 207 KAELPQRFEKEADAEKFLNDCAGAGFSVDSLETKPAKRNPAAPFTTSTLQQEASRKLGYS 266 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE- 359 V +TM +AQRLYE+G ITYMRTDS NLS+ A+ I +G KY P Y +K Sbjct: 267 VSRTMQIAQRLYESGRITYMRTDSVNLSETALQAAASEIRSAWGDKY--HQPRTYKTKSA 324 Query: 360 NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG- 418 +QEAHEAIRP+ N ++ Q+LY+LIW++ +A QM+ A ++ TT +G Sbjct: 325 GAQEAHEAIRPTYFNQHTV---PGDSSEQRLYELIWKRAIASQMSEALFEKTTAQIGIST 381 Query: 419 -DFRLKARGRILRFDGWTKVM------PALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 +L A G +L+FDG+ KV + + +LPA+++G ALTL + + F+ Sbjct: 382 RKEQLIAEGEVLKFDGFLKVYLESSDEEDAEDSEGNNMLPALSRGQALTLKVMNATERFS 441 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR---------------- 515 +PPAR++EASLVK+LE+ GIGRPSTYA ISTIQ+RGYV E+R Sbjct: 442 RPPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVVKEDRDGRQRSFAAIELSNGS 501 Query: 516 ---------------RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 + + +GE+V D L E+F+ +++++FTA +E D++A EW Sbjct: 502 VTKKTKTEITGAEKGKLFPTDIGEVVNDFLVEHFKGIVDFNFTANVEKEFDEIAQGLQEW 561 Query: 561 KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCS 620 +L F++ F +++ + E R N L +D P G+ + + G + Sbjct: 562 TKMLHSFYTPFHLEVE----NTLETADRANGERLLGLD-PATGKNVYTKVGRFGPLVQIG 616 Query: 621 --------GYALPPKERCKTTINLVPENEVLNV---LEGEDAETNALRAKRRCP--KCGT 667 YA K + T+ L E + LE + ++ R P K G Sbjct: 617 ENDDEEKPRYASLSKSQSVGTVTLEEALEQFKLPFSLEDYQGKEVSVGVGRFGPYVKWGD 676 Query: 668 AMDSYLIDPKRKLHVCGNNP-TCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG 726 A S + +P + D E D P+ + G + GRFG Sbjct: 677 AFISVPKNE---------DPLSIDQARAIEIIGEKITADAPVAHYQ--GMPVTKGTGRFG 725 Query: 727 KYMA 730 ++ Sbjct: 726 PFIK 729 >UniRef50_A9BI47 DNA topoisomerase n=3 Tax=Thermotogaceae RepID=A9BI47_PETMO Length = 762 Score = 566 bits (1459), Expect = e-159, Method: Composition-based stats. Identities = 252/793 (31%), Positives = 391/793 (49%), Gaps = 87/793 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K +VIVESP+KAKTI +YLG +Y V +S GHIRDLP Sbjct: 15 SKYVVIVESPSKAKTIERYLGKEYKVIASKGHIRDLPK---------------------- 52 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 GVD H++E ++V+PGKEKV+ E+K+ + + LA+D+DREGEAIAW Sbjct: 53 -------KEFGVDIEHDFEPIFQVIPGKEKVIQEIKKETKG-RKVLLASDMDREGEAIAW 104 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL +++ D +R++F+EITKNAI+ + + P L++ +V+AQ ARR +DR+VGY +SP Sbjct: 105 HLSQILDLDPKEKNRIIFSEITKNAIKNSISNPQSLDLKKVDAQIARRILDRLVGYKISP 164 Query: 182 LLWKKIAR-GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 L+WK + SAGRVQS A++L+V++ER+I F P++++ + + + +T Sbjct: 165 LVWKVLKDYKTSAGRVQSAALKLIVDKERKIFIFKPKKYFNIYLEYKGQN-----IPLTK 219 Query: 241 QNDKPFRPVNKEQTQA--AVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 ++ K +P + + + L+ + ++ E+K + KP PFITSTLQQAA + Sbjct: 220 EDGKKIKPESITKIKKDQIFEYLKDKDFKLVNVEEKESIRKPPLPFITSTLQQAAVSTFN 279 Query: 299 FGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 + K M +AQ LYE +ITYMRTDST +S +A Y+ N+GK Y+ Sbjct: 280 WASSKVMKIAQELYEGVETSEGSIAFITYMRTDSTRVSNEAQQAAINYLEKNYGKDYVGH 339 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKDM-EADAQKLYQLIWRQFVACQMTPAKYD 409 ++ K N Q+AHEAIRP+D+N+ + K + +D KLY LIW +F+A Q P++Y Sbjct: 340 YLSK-NKKSNVQDAHEAIRPTDINMDVNNAKRLISSDHLKLYTLIWNRFMASQSAPSRYL 398 Query: 410 STTLTVG--AGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 T T+ + + + FDG+ K K I K D +T +L Sbjct: 399 EKTYTIEDNTNKYAFEITSKKCIFDGFEKFWNPNNKEVNFEI----GKNDKITYDQLKFE 454 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV-RVENRRFYAEKMGEIV 526 + T PP R++EA+L+KELE +GIGRPSTYA+IIST+ R YV ++ G +V Sbjct: 455 EKETNPPNRYTEATLIKELESKGIGRPSTYATIISTLLQRKYVSKIAKSTLRPTTTGFVV 514 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG 586 TD LE F E+++ FTA ME LD++ + + + K VL+ F+ +F L A + + Sbjct: 515 TDFLETYFPEIVDVKFTANMEEDLDKIEDGKNKSKVVLEQFYKEFETFLSTASNNIK--N 572 Query: 587 MRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN-- 644 + + + C CG+ M + G++L C K ++ + E + Sbjct: 573 KKEILHYESDVPCEKCGKNMKLNFGRYGLYLSCEECKETQKIPAESFGVTIKEKLYIKEY 632 Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 + E + + +CP CG + + C N P C + Sbjct: 633 LQETLKIDKEENKIDEKCPICGGDLILKHGKFG-EFIACSNYPECKYTRNVKAR------ 685 Query: 705 DGPIVECEKCGSEMHLKMGRFGK-YMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPC 763 +C CG ++ + GK Y C + C E C Sbjct: 686 ----GKCPNCGGDIVKLKSKKGKTYFKCNS--CSTMYWNEP--------------SEYSC 725 Query: 764 EKSDAYFVLRDGA 776 + Sbjct: 726 PNCGETLFYKTSK 738 Score = 80.1 bits (196), Expect = 3e-13, Method: Composition-based stats. Identities = 31/101 (30%), Positives = 43/101 (42%), Gaps = 17/101 (16%) Query: 708 IVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLP-------- 759 V CEKCG M L GR+G Y++C EECK T+KI KE Sbjct: 582 DVPCEKCGKNMKLNFGRYGLYLSC--EECKETQKIPAESFGVTIKEKLYIKEYLQETLKI 639 Query: 760 -------ELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 + C +L+ G G F+A + +P+ + TR Sbjct: 640 DKEENKIDEKCPICGGDLILKHGKFGEFIACSNYPECKYTR 680 Score = 43.9 bits (102), Expect = 0.028, Method: Composition-based stats. Identities = 21/71 (29%), Positives = 32/71 (45%), Gaps = 9/71 (12%) Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKL---RYLA 815 ++PCEK L G G++L+ + +ET+ E F + EKL YL Sbjct: 581 SDVPCEKCGKNMKLNFGRYGLYLSCE---ECKETQKIPAE---SFGVTIKEKLYIKEYLQ 634 Query: 816 DAPQQDPEGNK 826 + + D E NK Sbjct: 635 ETLKIDKEENK 645 >UniRef50_Q31J81 DNA topoisomerase n=6 Tax=Bacteria RepID=Q31J81_THICR Length = 835 Score = 563 bits (1451), Expect = e-158, Method: Composition-based stats. Identities = 261/651 (40%), Positives = 374/651 (57%), Gaps = 75/651 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 LVIVESPAKAKTI KYLG + V+SS GHIRD+ G Sbjct: 2 TNLVIVESPAKAKTIEKYLGKGFTVRSSYGHIRDIQKKG--------------------- 40 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 MG+D + + +YE+ P K+K V+EL++L ++A+ ++LATD DREGEAIAWH Sbjct: 41 --------MGIDIENGFMPNYEISPDKKKTVTELRKLTKEAETVWLATDEDREGEAIAWH 92 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L E + D R+VF+EITK AI++A +P ++++D V AQQARR +DR+VG+ +SP+ Sbjct: 93 LAEALKLDVNDTKRIVFHEITKTAIQKAIAEPRKVDMDLVEAQQARRILDRIVGFELSPI 152 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LWKKI GLSAGRVQSVAVRL+VEREREI AF + + + + + Sbjct: 153 LWKKIRTGLSAGRVQSVAVRLIVEREREIDAFESDYVYRLQGALDILDESQQVVGAVEVK 212 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 + +E+ QA + +++A +V + E+KP P APF TSTLQQ AS++LGF VK Sbjct: 213 -RSAAFKTEEEAQAYLEQVKEAALTVSQLEEKPAKKSPKAPFTTSTLQQEASSKLGFSVK 271 Query: 303 KTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE-NS 361 +TMM+AQRLYE+G ITYMRTDS NLS++A+ I FG+ Y + +Y +K ++ Sbjct: 272 QTMMIAQRLYESGKITYMRTDSVNLSEEAIQKAHDEIVSEFGESY--STTRRYKTKNADA 329 Query: 362 QEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD-- 419 QEAHEAIRP+D +V + + E + Q+LYQLIWR+ +A QM A+ T + + Sbjct: 330 QEAHEAIRPTDFSVKSVT---GERNEQRLYQLIWRRAIASQMADAQLKRTNVDIALEGMP 386 Query: 420 -FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFS 478 +L A+G ++ FDG+ KV E + LP + G AL L EL Q F++PPAR++ Sbjct: 387 AEKLVAKGEVITFDGFLKVYNLDDDAKEGQ-LPPLKVGQALKLGELLVRQSFSRPPARYN 445 Query: 479 EASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR----------------------- 515 EASLV+ LE+ GIGRPSTYA I TIQ RGYV E+R Sbjct: 446 EASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVVKEDREGRQRDYRQLSLTVDGIDASTLT 505 Query: 516 --------RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 + + + IVTD L ++F ++++Y FTA +E+ D +A + W+ +L F Sbjct: 506 ETTGTEKNKLFPTDIAGIVTDFLVKHFGDVLDYKFTALVESEFDTIAQGKESWQEMLTKF 565 Query: 568 FSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG 618 + F ++D AE E + + + P G+ M ++ G ++ Sbjct: 566 YQQFHPRVDAAEDVSREEAGQSRAL----GNDPKTGKPMFVKIGRFGPYVQ 612 >UniRef50_A4RYV6 DNA topoisomerase (Fragment) n=5 Tax=cellular organisms RepID=A4RYV6_OSTLU Length = 840 Score = 558 bits (1439), Expect = e-157, Method: Composition-based stats. Identities = 233/691 (33%), Positives = 348/691 (50%), Gaps = 83/691 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 + L+IVESPAKAKTI KYLG++ V +S GH+RDL + Sbjct: 67 KRTLMIVESPAKAKTIEKYLGANAKVLASYGHVRDLVNKQGS------------------ 108 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 V P ++ + ++ + ++ + +K D + LATD DREGEAI+W Sbjct: 109 -----------VRPEESFAMTWTSTSRQKAAMRDITEALKKTDVLLLATDPDREGEAISW 157 Query: 122 HLREVIG-----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 HL EV+ DD RV F EITK A+ A P ++N+ V+A ARR +D + G Sbjct: 158 HLLEVLREKKLLRDDLDVKRVTFGEITKTAVLDAVGSPRDINVPMVDAYMARRALDYLFG 217 Query: 177 YMVSPLLWKKI--ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEAL 234 + +S LLW+K+ + LSAGRVQSVA+RLV ERE E++AFV E +W V AS ++ G Sbjct: 218 FTLSGLLWRKLPSSVSLSAGRVQSVALRLVCEREEEVEAFVSEPYWTVKASLSSKDGSTF 277 Query: 235 ALQVTHQNDKPFRPV----NKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 +TH + N E A + E V+E + G PF TST+Q Sbjct: 278 DAALTHVDGAKLGKFTIASNDEAEAYAKRVRECDTLRVVEVKHSEAKRTSGPPFTTSTMQ 337 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA-----GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 Q A+ +LGFG +TM AQRLYE G ITYMRTD T ++ A+ +R + FG Sbjct: 338 QEANKQLGFGASRTMSAAQRLYEGAGTGEGLITYMRTDGTYVAPHAIESLRTTAGELFGD 397 Query: 346 KYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDM---EADAQKLYQLIWRQFVAC 401 +Y+PESP + K +N+QEAHEAIRP+ + + +D +LY LIW + +A Sbjct: 398 EYVPESPRYFKKKQKNAQEAHEAIRPTKAGRLPAQVARQIGPGSDEARLYALIWARTMAS 457 Query: 402 QMTPAKYDSTTLTVGA--GDFRLKARGRILRFDGWTKVM----PALRKGDEDRILPAVNK 455 QM+PA D + + D +LKA G L+F G+ P +D LP + + Sbjct: 458 QMSPALTDRIAAEIASAENDLKLKANGHRLKFPGFLAAYRTSRPEAAPPSDDAWLPILGE 517 Query: 456 GDALTLVE------LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 G+ L++ +H T PP R+++ S+VK LE+RGIGRPSTYA I+ + R Y Sbjct: 518 GEGLSVKTDGESLGCEATEHKTSPPPRYTDGSIVKALEERGIGRPSTYAPILKVLAQREY 577 Query: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 V + G +V+ L F ++Y FTA +E+ LD + + + +WK +L+ +++ Sbjct: 578 VAKQGAALVPTTRGRLVSAFLTNYFETYVDYGFTADLEHKLDDITSEQVQWKPLLEEWWT 637 Query: 570 DFTQQL----------------DKAEKDPEEGGMRPNQMVLTSIDCPTCG-RKMGIRTAS 612 F ++ +K + + +V + CP+C ++G++ + Sbjct: 638 PFRDKISSLSELRVSEVIDALDEKLGQHLFGEATDSDDVVSEARRCPSCKIGRLGLKPSK 697 Query: 613 TGVFLGCSGYALPPKERCKTTINLVPENEVL 643 G F+GCS Y C T L P + Sbjct: 698 AGGFIGCSRYP-----ECGFTHPLHPIRGAI 723 >UniRef50_A8EWX5 DNA topoisomerase I n=2 Tax=Campylobacterales RepID=A8EWX5_ARCB4 Length = 756 Score = 555 bits (1429), Expect = e-156, Method: Composition-based stats. Identities = 256/731 (35%), Positives = 384/731 (52%), Gaps = 64/731 (8%) Query: 28 KSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLP 87 +S+GH+RDLP S +G DP N++ Y++ Sbjct: 1 MASMGHVRDLPKSS-----------------------------LGFDPNDNFKPKYQIST 31 Query: 88 GKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAI 147 K+KV+++LK+ K IYLA D DREGEAIAWHL + + R+VF+EITK+AI Sbjct: 32 DKKKVITDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAI 91 Query: 148 RQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVER 207 +A P +++ + V+AQQARR +DR VGY +SPLLWKK+ GLSAGRVQSVAVR++V+R Sbjct: 92 LKALENPRDVDQNLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDR 151 Query: 208 EREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYS 267 E EI+AFVPEE+W++ A P L ++ +N K + N++Q + L++ Y Sbjct: 152 ENEIRAFVPEEYWKIKADFINPE---LKAELAKENGKTLKISNEKQALEIEASLKQGSYK 208 Query: 268 VLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE----------AGYI 317 +++ E+K +T P APF TSTLQQ AS +LGF VK+TM++AQ+LYE G I Sbjct: 209 LVDIEEKESTRNPAAPFTTSTLQQEASRKLGFSVKQTMIIAQQLYEGNVGNIPNHTGGLI 268 Query: 318 TYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVM 376 TYMRTDS NLS A + I + +GK+Y P Y +K + +QEAHEAIRP ++ + Sbjct: 269 TYMRTDSLNLSTVATTAAKAVIEEEYGKEYALNKPRVYTTKSKGAQEAHEAIRPVNLALR 328 Query: 377 AESLKDM-EADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG---DFRLKARGRILRFD 432 +K+ E +LY LIW++ +A QM AK +TT + AG +F + +G+ + F Sbjct: 329 PSQIKEFVEPAQYRLYSLIWKRTLATQMAQAKIANTTYKIEAGKNKEFEFQVKGQRIIFA 388 Query: 433 GWTKVMPALRKGDE------DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL 486 G+ K E ++ILP + +G L L +L Q+FTKPPAR++EASLVK+L Sbjct: 389 GFMKAYTEGSDNPEAALDSSEKILPNIKEGTILELEKLESEQNFTKPPARYTEASLVKKL 448 Query: 487 EKRGIGRPSTYASIISTIQDRGYV-RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQ 545 E GIGRPSTYA ISTIQ R YV + E+ + + GEIV L ++F +++ FTA+ Sbjct: 449 ESEGIGRPSTYAPTISTIQAREYVSKTEDNKLIPTQTGEIVNSFLVDHFSNIVDLGFTAK 508 Query: 546 MENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK 605 +E D++A + W+ V+ +F+ F + +D+ E + + P G+ Sbjct: 509 IEEEFDEIAEGKIAWEEVMKNFYGGFKKTIDEKESSVSKEDYLQVNELGID---PKSGKP 565 Query: 606 MGIRTASTGVFLGCSGYALPPKERC-----KTTINLVPENEVLNVLEGEDAETNALRAKR 660 + R G F+ K + ++ + E L + N Sbjct: 566 VSARVGRFGPFVQIGTKDDEEKPKFVAIPDNLNMDTITLEEALFLFNLPRVVGNTENGDE 625 Query: 661 RCPKCGTAMDSYLIDPKRKLHVCGNNP-TCDGYEIEEGEFRIKGYDGPIVECEKCGSEMH 719 G YL + + ++P T D E I ++ Sbjct: 626 IKANIGR-FGPYLQVKTKFYSLKTDDPYTIDLNRALEIIKDIDEAKEKSTIKTFDKEKIQ 684 Query: 720 LKMGRFGKYMA 730 + +G++G Y+ Sbjct: 685 ILVGQYGPYIK 695 >UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=A4JTK7_BURVG Length = 893 Score = 553 bits (1425), Expect = e-155, Method: Composition-based stats. Identities = 196/900 (21%), Positives = 329/900 (36%), Gaps = 153/900 (17%) Query: 1 MGKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSAD 49 MGK L+I E P+ AK I LG D ++ S+ GH+ ++ ++ Sbjct: 1 MGKTLIIAEKPSVAKDIALALGGFGRVDNWLESPDAIISSAQGHLVEVFSTLM------- 53 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIY 107 D G + + V P +++ + ++ ++LK+L + D + Sbjct: 54 ------------DTSGKDLQSLPVIP-PSFDLRVIDGANRPQLFAQLKRLMSRQDVDAVV 100 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQ 165 A D REGE I + + + G R+ F +T AIR++F+ KPG +A Sbjct: 101 NACDAGREGELIFRLIYK-LAGCTKPMKRMWFRSMTPEAIRESFHSMKPGADFDGLSDAA 159 Query: 166 QARRFMDRVVGYMVSPLLWKKIAR------GLSAGRVQSVAVRLVVEREREIKAFVPEEF 219 R D +VG S + + R S GRVQ+ LV +RE I+ F +++ Sbjct: 160 FCRTEGDYLVGINGSRGVTRLYERQTASVENRSVGRVQTPTGALVYDREMAIRTFRAKDY 219 Query: 220 WEVDASTTTPSGEALALQVT-------------------HQNDKPFRPVNKEQTQAAVSL 260 WEV +G + ++ R K++ A V+ Sbjct: 220 WEVHGHFGVAAGNYVGKWFDPNFKASGEQQELGEGGGSGKSDETANRFFEKDRADAIVAK 279 Query: 261 LEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT-Y 319 + + E KPT + ++LQ+ A+ +LG K+T+ +AQ LYE +T Y Sbjct: 280 CSGTNPTDVREESKPTAKGSPRLYDLTSLQREANRKLGLSSKRTLDIAQALYEKHKVTTY 339 Query: 320 MRTDSTNLSQDAVNMVRGYISDNFGKKYLPE----------SPNQYASKENSQEAHEAIR 369 RTDS+ L +D V + I G Y P P++ H AI Sbjct: 340 PRTDSSFLPEDYVAKAQSTIESLVGTTYEPHAKRVIDGGWVKPDKKIFDNGKISDHFAII 399 Query: 370 PSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRIL 429 P+ + + + + K+Y +I R+F+A A+Y TT K+ GR+L Sbjct: 400 PTG-----KRPEGLTPEEGKVYDMIVRRFLAVFHPAAQYQVTTRITVVAGEHFKSSGRVL 454 Query: 430 RFDGWTKVMPALRKGDEDRI--LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE 487 +GW V A ++ + L G+A+T V + TKPP R++E +L+ +E Sbjct: 455 ISEGWMAVYGADVDDEDKKTPALVKYEAGEAVTTVRIELKTLKTKPPLRYTEDTLLAAME 514 Query: 488 ----------------KRGIGRPSTYASIISTIQDRG---------YVRVENRRFYAEKM 522 +RG+G P+T A+II + Y++ + + Sbjct: 515 SAGKFVDDDELADAMKERGLGTPATRAAIIEGLLADKDGKGNPKEPYLKRDGKSLVPTPK 574 Query: 523 GEIVTDRLEENFRELM-NYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 + + L N EL+ + T + E+ L + E A + Q +D K Sbjct: 575 LISLIEFLRNNGIELLASPKLTGEWEHKLRLIERGEYRRDAFNNEIGDLTRQIIDAIRKK 634 Query: 582 PEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC---------------------- 619 E ++ CP CG ++ I + C Sbjct: 635 AAEVVVKKLDA-----KCPQCGGEIAIGARTFDCESACGFRLWKEIAGRQLKPSEANTLL 689 Query: 620 --------SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDS 671 + + K++ + L E++V + T+A CP C M Sbjct: 690 TTRVVMNLNNFISNSKKKFTACLRLNDEHKVEFFFDETVNTTDASGNPVHCPVCEKLM-R 748 Query: 672 YLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMAC 731 + C + C + + C KC S+M+ G+ G + +C Sbjct: 749 RISGANGHFWSCTDRENCKTTLDDSAGNPV--PKVAAQPCPKCSSDMNRVRGKKGYFWSC 806 Query: 732 TNEE-CKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLR--DGAAGVFLAANTFPK 788 T+ E CKNT V P + C A R G F + F K Sbjct: 807 TDREGCKNTMDDKDGAPVTRP-------DPIACPDCGAQMFRRERRDKKGYFWGCSAFKK 859 Score = 60.1 bits (144), Expect = 3e-07, Method: Composition-based stats. Identities = 23/131 (17%), Positives = 36/131 (27%), Gaps = 23/131 (17%) Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 + + ++ P V + CP C M G F C+ +E CK T++ Sbjct: 764 ENCKTTLDDSAGNPVPKVA-AQPCPKCSSDMNRVRGKKGYFWSCT-----DREGCKNTMD 817 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYL-IDPKRKLHVCGNNPT----CD 690 +D CP CG M D K C C Sbjct: 818 ------------DKDGAPVTRPDPIACPDCGAQMFRRERRDKKGYFWGCSAFKKDGGGCG 865 Query: 691 GYEIEEGEFRI 701 ++ + Sbjct: 866 CILQDDNGKPV 876 >UniRef50_D2QCS0 DNA topoisomerase I n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QCS0_9SPHI Length = 894 Score = 553 bits (1425), Expect = e-155, Method: Composition-based stats. Identities = 254/686 (37%), Positives = 367/686 (53%), Gaps = 114/686 (16%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI YLG D+ VKSS GH+RDLP G Sbjct: 1 MSKNLVIVESPAKAKTIEGYLGKDFTVKSSFGHVRDLPKDG------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VD + + YE+ P K+K+VSELK LA+ A+ ++LATD DREGEAI+ Sbjct: 42 ----------LAVDVTNGFRPSYEISPDKKKLVSELKSLAKSAEEVWLATDDDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+E +G D R+VF EITKNAI A P +++D VNAQQARR +DR+VGY +S Sbjct: 92 WHLKEALGLRD-NTKRIVFREITKNAILNAIKSPRTIDVDLVNAQQARRVLDRLVGYELS 150 Query: 181 PLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 P+LW+KI G LSAGRVQSVA+RLVVEREREI + ++V A + L + Sbjct: 151 PVLWRKIKGGSTGLSAGRVQSVALRLVVEREREIDKHSAKSSFKVTAQFIVDGNKVLNAE 210 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + P + +A + A +++ E +P P PF TSTLQQ +S +L Sbjct: 211 L------PKNFATAAEARAFLEACVGATFTIKNLETRPAKKSPAPPFTTSTLQQESSRKL 264 Query: 298 GFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYAS 357 + V +TM +AQ LYEAG I+YMRTDSTNLSQ+A++ I FG+KY+ Q+ + Sbjct: 265 SYSVDRTMRIAQNLYEAGKISYMRTDSTNLSQEAIDKAVAEIGTEFGEKYI--QTRQFKT 322 Query: 358 KE-NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVG 416 K ++QEAHEAIRP++ N + + D ++LY+LIW++ +A QM A+ + TT+T+G Sbjct: 323 KNESAQEAHEAIRPTNFNDRSA---GGDRDQKRLYELIWKRAIASQMADAQLERTTVTIG 379 Query: 417 AG-------------------------------DFRLKARGRILRFDGWTKVMPALRKGD 445 L A+G +++FDG+ +V + + Sbjct: 380 IRFANGATTTFQTNVDDSPFVETPEAIAPNRSFPNELVAQGEVIKFDGFLRVYLESKDDE 439 Query: 446 EDR----ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASII 501 +D +LP +N G L L ++ + FT+P R++EASLVK+LE+ GIGRPSTYA I Sbjct: 440 DDEDAKGMLPPLNIGQGLNLGQMKATEKFTRPQPRYAEASLVKKLEEMGIGRPSTYAPTI 499 Query: 502 STIQDRGYVRVENR-------------------------------RFYAEKMGEIVTDRL 530 STI +RGYV +++ + + G +V D L Sbjct: 500 STIVNRGYVTKQDKPGQERKYTEYTLQQNQISETSGKETYGSEKAKLFPTNTGIVVNDFL 559 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 E F ++++Y FTA +E D++A+ W+ +L F+ DF + ++ + Sbjct: 560 VEYFPDIVDYKFTATVEKEFDEIADGRMNWQTMLQDFYGDFHKNIEDIQGSSVVAFKTGA 619 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVF 616 + + P G+K+ R G + Sbjct: 620 RDLGID---PRSGKKISARLGKYGAY 642 >UniRef50_B7I2H2 DNA topoisomerase n=4 Tax=Proteobacteria RepID=B7I2H2_ACIB5 Length = 672 Score = 553 bits (1424), Expect = e-155, Method: Composition-based stats. Identities = 238/710 (33%), Positives = 336/710 (47%), Gaps = 81/710 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 LVIVESP K K I+ LG+ Y V +SVGH+RDLP Sbjct: 2 TTLVIVESPGKVKKISALLGAGYKVVASVGHVRDLP------------------------ 37 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +G++P ++ HY+ V++ LK+ AD I LATD DREGEAIAWH Sbjct: 38 -----PKELGIEP-PDFRPHYQPTERGRDVLARLKKDVAAADRILLATDPDREGEAIAWH 91 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L + + D R+ F ITK+ ++ A P ++++RV +Q+ARR +DR+VGY VSP Sbjct: 92 LADALKLRDP--QRITFTAITKDKVQAAVAAPRRIDMNRVRSQEARRALDRIVGYRVSPA 149 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 L + + LSAGRVQS AVRLVV+REREI +F E + + + G A + Sbjct: 150 LSDRAGQPLSAGRVQSPAVRLVVDREREIASFKVTEHYGAELTFDNGDGTAWRAVWDTKP 209 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 A+ + +V E D P APF TSTLQQAA RL K Sbjct: 210 HMAEGESYIMDDALALRVAAVRHVTVAEVADTEKGRAPAAPFTTSTLQQAAGQRLKLRPK 269 Query: 303 KTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQ 362 KTM +AQRLYE G ITY RTD+ N+ + + Y L E P ++ +KE +Q Sbjct: 270 KTMELAQRLYEQGAITYHRTDAPNMDDAGMEDIAAYARS--AGLPLAEKPRRWKAKEGAQ 327 Query: 363 EAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF-- 420 E HEAIRP+ + D D + LY+LIW++ VA Q+ A Y ++ + Sbjct: 328 EGHEAIRPTHAADLEAGETD---DEKALYRLIWQRAVASQLADAIYAVRSVRLAGDAEGL 384 Query: 421 --RLKARGRILRFDGWTKVM------PALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 A GR L+ GW V + +PA+ +G LT TK Sbjct: 385 AVAFTATGRTLQSPGWMAVYAADADDSDDEGEASNNPIPALAEGAGLTASSGRLLTKHTK 444 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV-RVENRRFYAEKMGEIVTDRLE 531 PP RF+EA+LVKE+E+ GIGRPSTYA+II I RGYV + +GE + D L Sbjct: 445 PPTRFTEATLVKEMERLGIGRPSTYAAIIENITGRGYVIEGQKGYLTPSPIGETIRDALV 504 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 F D+T +E+ LDQ+A +A+++ V+ +S +L K + + Sbjct: 505 GRF-RFAELDYTRGLEDELDQIAEAKADYQGVISAAWSALDDELGKLD----------SA 553 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 + + CP CG+ + R G F C+GY CKT++ + + Sbjct: 554 GIAAAHPCPACGKALHRRKGQYGFFWSCTGYP-----ECKTSLPD-------DKGKPGQR 601 Query: 652 ETNALRAKRRCPKCGTAMDSY--LIDPKRK--------LHVCGNNPTCDG 691 + +CPKCG + + PK+K + C P CD Sbjct: 602 KAPPPSTGFQCPKCGKELARRQGVSKPKKKGMKGRPYDFYSCTGYPKCDA 651 Score = 79.4 bits (194), Expect = 6e-13, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 33/93 (35%), Gaps = 14/93 (15%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD 767 C CG +H + G++G + +CT ECK + + ++ P P C K Sbjct: 559 HPCPACGKALHRRKGQYGFFWSCTGYPECKT--SLPDDKGKPGQRKAPPPSTGFQCPKCG 616 Query: 768 AYFVLRDG-----AAG------VFLAANTFPKS 789 R G G F + +PK Sbjct: 617 KELARRQGVSKPKKKGMKGRPYDFYSCTGYPKC 649 Score = 52.4 bits (124), Expect = 7e-05, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 11/29 (37%) Query: 762 PCEKSDAYFVLRDGAAGVFLAANTFPKSR 790 PC R G G F + +P+ + Sbjct: 560 PCPACGKALHRRKGQYGFFWSCTGYPECK 588 >UniRef50_C3JAB5 DNA topoisomerase n=3 Tax=Bacteria RepID=C3JAB5_9PORP Length = 837 Score = 550 bits (1417), Expect = e-155, Method: Composition-based stats. Identities = 261/785 (33%), Positives = 383/785 (48%), Gaps = 103/785 (13%) Query: 1 MGKA--LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 M K LVIVESPAKAKTI K+LG + V SS GHIRDL SG Sbjct: 50 MQKTPNLVIVESPAKAKTIEKFLGKGFRVLSSYGHIRDLKKSG----------------- 92 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEA 118 +G+D + +Y V K VV +LK A+ A+ ++LA+D DREGEA Sbjct: 93 ------------LGIDISQQFAPNYIVSKDKLAVVRDLKHAADNAEMVWLASDEDREGEA 140 Query: 119 IAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 IAWHL EV+ R+VF+EIT+ AI A P +++++ V+AQQARR +DR+VG+ Sbjct: 141 IAWHLYEVLERAGKPTKRIVFHEITQQAIDYAIAHPRDIDLNLVDAQQARRVLDRIVGFE 200 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP-SGEALALQ 237 +SP+LWK+I LSAGRVQSVAVRL+V+REREI+ F P ++V AS GE L Sbjct: 201 LSPILWKRIKPALSAGRVQSVAVRLIVDREREIQQFSPSSSYKVIASLCKQTEGETLQAI 260 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 D E+ + +S VL KP P APF TSTLQQ A+ +L Sbjct: 261 AEKTFD------TAEEAKNFLSRNSAQEMEVLSLVSKPGKRSPAAPFTTSTLQQEAARKL 314 Query: 298 GFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYAS 357 G+ V TM +AQ+LYE+G+ITYMRTDS NLS A+N I + +G+ Y + Sbjct: 315 GYTVGTTMRIAQKLYESGHITYMRTDSVNLSTLALNSAAKAIKERWGESYY-QLRKYKTK 373 Query: 358 KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA 417 + +QEAHEAIRP+D++ ES+ QKLY++I ++ +A QM + TT T Sbjct: 374 SKGAQEAHEAIRPTDLS--KESISG-TPQEQKLYEMIHKRTLASQMADVVLEKTTATFRG 430 Query: 418 G--DFRLKARGRILRFDGWTKVMPALRKGDEDRI------LPAVNKGDALTLVELTPAQH 469 + A G ++RF+G+ K DE+ LP ++KG+ L EL +H Sbjct: 431 QTSNDVFVAEGEVIRFEGFLKAYDYASHSDEEEEKNNSHQLPTLSKGELLNTQELVATEH 490 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV----------------- 512 T+ PAR+SEASLV+ LE+ GIGRPSTYA I IQ R YV+ Sbjct: 491 ITRAPARYSEASLVRRLEELGIGRPSTYAPTIQVIQAREYVQKGTGNGTEHQYHDYICNA 550 Query: 513 ----------------ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 + + +G +V D L ENF ++++Y+FTAQ+E D++A Sbjct: 551 QHPTPTLKIRTEKIGADKGKLLPTDIGIVVNDFLVENFPKVIDYNFTAQVEGLFDRIAEG 610 Query: 557 EAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVF 616 + W ++HF++ F ++ A + + + + P+ + + R G Sbjct: 611 KEIWTNTMEHFYTLFHPMVETALESFDNHARGERLLGVD----PSTNKAVMARIGRYGPL 666 Query: 617 LGC--------SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 + + +A + + TI L ++ + + K + G Sbjct: 667 VQIGENTPTEKASFASLREGQSIQTITLEEALDLFKLPRT-PGQFEGNDVKVASGRFGPY 725 Query: 669 M---DSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRF 725 + + PK+ + C + E IK E + + ++ GRF Sbjct: 726 IQHAGKFTSIPKQYDPLSITLDECIALIQAKREEEIKAELKRFSEDPE----LTIRTGRF 781 Query: 726 GKYMA 730 G ++ Sbjct: 782 GPFLK 786 >UniRef50_B1M9R9 DNA topoisomerase I n=4 Tax=root RepID=B1M9R9_METRJ Length = 788 Score = 550 bits (1416), Expect = e-154, Method: Composition-based stats. Identities = 238/816 (29%), Positives = 357/816 (43%), Gaps = 94/816 (11%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L++VESP K +I YLG D+ V +S GHIRDLP K D + P+K Sbjct: 2 KLMVVESPNKVASIQGYLGDDWKVVASSGHIRDLPQREFGISK-PDFSLQYEYIPPQKVG 60 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 + PG V+ +K+ KAD +YLATD DREGEAI+WHL Sbjct: 61 N-------------------KTFPGAADRVARIKREVAKADAVYLATDPDREGEAISWHL 101 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 +E + + Y RV F EIT AI+ A +++D V+AQ+ RR +DR VGYMVSPLL Sbjct: 102 KEALQLGEDDYERVTFTEITPKAIQAALRAARRIDMDLVHAQEGRRALDRFVGYMVSPLL 161 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 + LSAGRVQSVAVRLVV+ ER I AF + + + +G + Q + Sbjct: 162 SDMLGMNLSAGRVQSVAVRLVVDLERRIAAFKSTKHFSAVVTFDAGAGAKWSAQWDTKPY 221 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 A + ++ VLE + + + +P +P T + +AAST L Sbjct: 222 VTEDSPYVLDEALAAKASQSRQFVVLESKTEEKSERPPSPLSTLGMLRAASTALKMSSAA 281 Query: 304 TMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQE 363 T AQ+L+E G+ITY+RTDS NLS DA + VR + + L ++ K ++Q Sbjct: 282 TTKAAQKLFEDGHITYIRTDSVNLSPDAADKVRSFAASQ--GMALSPEVRRWKEKASAQG 339 Query: 364 AH-EAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA---GD 419 H +A+RP+ + V D + LY+LI + + QM A+Y T+ + A Sbjct: 340 GHADAVRPTHIEVEDAGADD---AQRALYRLIRLRTLVSQMADARYTVNTVRLRATDRDG 396 Query: 420 FRLKARGRILRFDGWTKVMPALRKGDE--------DRILPAVNKGDALTLVELTPAQHFT 471 F ARGR + GW ++ +E D +P + G L ++ T Sbjct: 397 FEYVARGRKMIDAGWRALLERDPDEEENSDDDAAKDGQVPRLAVGGDLRAIDGKVLDKKT 456 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR-FYAEKMGEIVTDRL 530 +PP RF+EA+L+++LE G+GRP+T+A+I++ + R YV ++ +R ++GE+V D L Sbjct: 457 EPPRRFTEATLLQKLEDEGVGRPATFAAIMTNVLGRSYVELDKKRCLLPTEIGELVVDNL 516 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 M FT ++E LD +A +A ++ V++ + ++L + E Sbjct: 517 LRGQFGFMELGFTRELEVQLDAIAEGKASYRDVVEPAYRQLNEELARIAVSGE------- 569 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGV--FLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 CP CG M R A G F C+ E E Sbjct: 570 --FTPRFKCPKCGTGM-RRYAKPGKSPFWRCTA-----------------EAETCGHYMD 609 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 +D R CP+CG + + G C E + G + Sbjct: 610 DDKGKPVERTAHPCPRCGETLRRFKRKNGG-----GLVWVCPAEACETFLDDVGGKPVAL 664 Query: 709 VECEKCGSEMH----------LKMGRFGKYMACTNEE-CKNTRKILRNGEVAPPKEDPVP 757 C KC + + G FG + CT+ E CK K PV Sbjct: 665 HTCTKCNAPLRRYQKKDRETGKPTGAFGWF--CTDTENCKTFMDDD--------KGRPVA 714 Query: 758 LPELPCEKSDAYFVLRDGAAGVFLAANTFPK-SRET 792 + PC K R G G + + + + + Sbjct: 715 IKTAPCPKCGKAMYRRKGDHGFWWGCSGYREGCKTI 750 >UniRef50_C5Z4V5 DNA topoisomerase (Fragment) n=12 Tax=cellular organisms RepID=C5Z4V5_SORBI Length = 1094 Score = 548 bits (1412), Expect = e-154, Method: Composition-based stats. Identities = 236/789 (29%), Positives = 373/789 (47%), Gaps = 98/789 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K++V+VES KAK I YLG Y V S GH+RDL + Sbjct: 309 AKSVVVVESATKAKVIQNYLGDMYEVLPSYGHVRDLAGRSKS------------------ 350 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 V P ++ +EV + +K + A+++ LA+D DREGEAIAW Sbjct: 351 -----------VRPDDDFSMVWEVPAAAWTHLKSIKVALKGAENLILASDPDREGEAIAW 399 Query: 122 HLREVIG-----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 H++E++ G D +RV F+EIT++AI++A P +++D VNA ARR +D ++G Sbjct: 400 HIKEMLEQQGALGCDVTVARVAFHEITEDAIKKALMSPRYIDMDLVNAYLARRSLDYLIG 459 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT-----PSG 231 + +SPLLW+K+ SAGRVQS A+ LV +RE EI+ F P+E+W V P+G Sbjct: 460 FGISPLLWRKLPGCQSAGRVQSAALALVCDREAEIEQFKPQEYWTVQTYFKMHFADPPNG 519 Query: 232 EALALQVTHQNDKPFRPV---NKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 + ++ H N K + ++E+ QA + +++ VL + P P+ITS+ Sbjct: 520 TYIPFRIKHLNSKKLDQLSIRSQEEAQAIEKRIHSSKFEVLGVKRSKIHKNPPMPYITSS 579 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYI 339 LQQ A+ +L F TM +AQ+LYE G ITY+RTD ++S A +R + Sbjct: 580 LQQDAANKLHFTAGYTMKIAQKLYEGINLSSEETTGLITYIRTDGFHVSDGAAEDIRSLV 639 Query: 340 SDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQ 397 + +G+KY+ E +Y K +N+QEAHEAIRP+ + + SL ++ D+ KLY LIW++ Sbjct: 640 KERYGQKYVSEDTRKYLKKVKNAQEAHEAIRPTSIRRLPSSLVGILDDDSLKLYTLIWKR 699 Query: 398 FVACQMTPAKYDSTTLTVGA--GDFRLKARGRILRFDGWTKVMPALR------------- 442 +ACQM ++ + + +G G+ + L F G+ V Sbjct: 700 TMACQMEASRTEMIQVDIGTPEGEMIFHSVASKLDFKGYQAVYEDTEAIPCSDNSERDSV 759 Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 D L + D + V + QHFTKPP+R+SE +L+K+LE+ GIGRPSTYASI+ Sbjct: 760 DEDNFEALSKLMVKDLVFPVNVHLGQHFTKPPSRYSEGALIKKLEELGIGRPSTYASIMK 819 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 +QDR YV ++R + E G +V+ L +F E+ +Y FTA ME LD V+ EWK Sbjct: 820 VLQDRKYVTAKSRVLHPEFRGRMVSAFLLHHFSEVADYSFTANMETELDNVSAGSTEWKG 879 Query: 563 VLDHFFSDFTQQLDKAEK----------DPEEGGMRPNQMVLTSIDCPTCGRK-MGIRTA 611 +L ++ F + A K + + G + + S CP+C + + + Sbjct: 880 LLKDYWERFNKYCADASKLDGRKVERMLEEKFGPILFPDVDKDSRICPSCSEGTLRFKVS 939 Query: 612 ST--GVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKC---- 665 G F+GC + +CK + + E E ++ R P Sbjct: 940 RYGEGYFIGCDRHP-----KCKYIARSLSQQEDETEPTEESPKSFTPRLLGVMPDSDQKV 994 Query: 666 -------GTAMDSYLIDPKRKLHVCGNNPTCDGYEI-EEGEFRIKGYDGPIVECEKCGSE 717 G + + D + E + Y + + + Sbjct: 995 FLKQGPYGYYVQIGEDKKGLFPKRASLSEVKDIDSVTLEDAIELLQYPKILGKHPEDDHP 1054 Query: 718 MHLKMGRFG 726 + + + G Sbjct: 1055 VLITHSKVG 1063 >UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_GEOSY Length = 697 Score = 545 bits (1403), Expect = e-153, Method: Composition-based stats. Identities = 184/703 (26%), Positives = 300/703 (42%), Gaps = 86/703 (12%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ A+ I + LG Y+V ++GH+ +L +K Sbjct: 2 KSLVLAEKPSVARDIARVLGCKETHKPYFEGPRYIVTWALGHLVELKMPEDYDRKYETWR 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADH--IYLA 109 PK + +V+ +++LA++ D + +A Sbjct: 62 LEDLPIIPK-------------------KMGLKVIRQTSHQFRAIERLAKRPDVKDVIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQA 167 TD REGE +A + E+IG R+ + T AIR F KPG + Sbjct: 103 TDAGREGELVARWILEMIGW-TKPIWRLWISSQTDRAIRDGFRQLKPGAQFDRLYQSAVC 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D ++G VS L K LSAGRVQ+ + +++EREREI++FVP +W + A Sbjct: 162 RAEADWLIGLNVSRALTTKYNDPLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKIG 221 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + + + R ++++ + ++ L+ V+ + K + P+ + Sbjct: 222 S-------ITAVWERHGGHRLFDQDEAKQLLARLDGQPARVVSVKRKRKSEPAPLPYDLT 274 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYI---SDNF 343 LQ+ A+ R GF KKT+ + QRLYE +TY RTDS L D + + + Sbjct: 275 ELQRDANKRFGFSAKKTLSVLQRLYEQHKLVTYPRTDSRYLPSDMEATMTERLLAMKSGY 334 Query: 344 GKKYLP------ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 P + ++ H AI P+D + +L + D +KLY LI R+ Sbjct: 335 EDVIAPLLAKGKAKAAKRVFNDDKVTDHHAIVPTDERL---NLSRLSTDERKLYDLIARR 391 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 F+A P + ++TT G A+ + G+ V+ + D L + +G Sbjct: 392 FLALFFPPYESETTTAVFDIGGEMFVAKETAVVNFGFKAVL-GKEETDAKPTLSHLAEGQ 450 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L V+L Q FT+PPAR+SEA L+ ++EK G+G P+T A II + + V ++ RF Sbjct: 451 TLPSVQLEREQSFTEPPARYSEADLLAQMEKYGLGTPATRADIIERLVETEVVERKDGRF 510 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 Y K G+ + + + E EL + + TA+ E L+ +A + + L + TQQL Sbjct: 511 YPTKKGKQLIELVNE---ELKSPELTARWERELEAIARGKGNPQQFLANIRRQ-TQQLVA 566 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV 637 K E+ PN LT++ CP CG + R G L CS A + R Sbjct: 567 EIKQSEQVYKAPN---LTNLTCPECGALLKERKTKDGRMLVCSNLACRYRRR-------- 615 Query: 638 PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 + + RRCP+C M+ + Sbjct: 616 ---------------RDPKLSNRRCPQCHRRMEMHEGKAGMYF 643 Score = 53.6 bits (127), Expect = 3e-05, Method: Composition-based stats. Identities = 17/91 (18%), Positives = 36/91 (39%), Gaps = 12/91 (13%) Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 EI++ E K + + C +CG+ + + + G+ + C+N C+ R+ Sbjct: 567 EIKQSEQVYKAPNLTNLTCPECGALLKERKTKDGRMLVCSNLACRYRRR----------- 615 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAA 783 L C + + +G AG++ Sbjct: 616 -RDPKLSNRRCPQCHRRMEMHEGKAGMYFQC 645 >UniRef50_Q3M6J7 DNA topoisomerase n=12 Tax=Cyanobacteria RepID=Q3M6J7_ANAVT Length = 728 Score = 544 bits (1401), Expect = e-153, Method: Composition-based stats. Identities = 225/726 (30%), Positives = 355/726 (48%), Gaps = 72/726 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L++VESP K K +++ LGS+++V++S GHIR+L G A + + Sbjct: 1 MPKRLLVVESPGKVKKLSQILGSEWIVRASCGHIRELSDEGEDALGFSMDGGSVQCHYVP 60 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +D+R ++ + +LK A++ + LATD DREGE IA Sbjct: 61 RDQR------------------------SKETIQQLKSAAKQVSEVVLATDPDREGETIA 96 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+EV+G + RVV+ EIT +A++ A P +L+++ V A R +D++VGY S Sbjct: 97 WHLKEVLGLREP--KRVVYTEITASAVQSAIAHPRKLDLNLVGAGLCRDCLDKLVGYKGS 154 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PL+W S GRVQS + L+ +REREI++FVP+++W V V Sbjct: 155 PLVWALNNGAKSVGRVQSSTLHLICQREREIQSFVPQDYWSVWVDYVEGFRAFYKGAVNT 214 Query: 241 QNDKPF--------------------RPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 ++D P R + + + V + + +++ E K +P Sbjct: 215 RSDSPETEVEIHDDAAGNSTTAPESTRVLAEAEANRLVEEARRHPHQIVQYEGKIANRQP 274 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS 340 PFITSTLQQAA ++L F +KTM +AQ+LYEAG ITYMRTDS LS + R ++ Sbjct: 275 PPPFITSTLQQAAGSKLKFAPEKTMQLAQKLYEAGLITYMRTDSVMLSPEFCESARQWLE 334 Query: 341 DNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFV 399 N + +P+ ++ S + +Q+ HEAIRP+DV + L+ ++ D LY +IW++ + Sbjct: 335 QNDPQN-VPKQVARHRSSKTAQQGHEAIRPTDVFRPSAQLRIELSTDEFNLYVMIWKRAI 393 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 A Q PA+ T + +G +ARG+++ F G+T+ P L K D +LP + +G + Sbjct: 394 ASQCRPAQLRKTVVITQSGQILWQARGQVVEFLGYTRYWPNLSK---DTLLPTLQQGQMV 450 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 TL + T+PP R+SE LV+ +E++GIGRPSTY+ I+T++ RGYV + + Sbjct: 451 TLENAGHEKKQTQPPPRYSEPKLVQLMERKGIGRPSTYSPTIATLKKRGYVELTKDNLHP 510 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD-FTQQLDKA 578 +G V L++ +L+ +FTA+MEN+LD +A + W+ L + + F L KA Sbjct: 511 TNLGLEVDTFLQKALPDLLEAEFTAKMENALDAIAEGKQPWQIYLTTWNQNYFAPALAKA 570 Query: 579 EKDPEEGG-----MRPNQMVLTSIDCPTCGRKMGIR---TASTGVFL----GCSGYALPP 626 + + G P Q + CP C + FL GC L Sbjct: 571 KTIAVDSGNPTKTFPPRQYDTSRTRCPDCNNFLSKIPSSKLKKKYFLKCTSGCENTVLFW 630 Query: 627 KERCKT-----TINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSY---LIDPKR 678 E KT T + + CP C ++ Y K+ Sbjct: 631 SEFSKTWQAPRTKDDKMAENGQKNHLSPATKLPTQLTAYPCPVCKRPLEEYTYTKDGQKK 690 Query: 679 KLHVCG 684 + C Sbjct: 691 TMLRCS 696 >UniRef50_B5TTQ4 TraB n=3 Tax=environmental samples RepID=B5TTQ4_9BACT Length = 750 Score = 542 bits (1396), Expect = e-152, Method: Composition-based stats. Identities = 241/805 (29%), Positives = 386/805 (47%), Gaps = 99/805 (12%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LVIVESP K I +LGSD+ V +SVGH+RDLP G Sbjct: 2 NLVIVESPNKCSKIGSFLGSDFKVVASVGHVRDLPRKG---------------------- 39 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKE----------KVVSELKQLAEKADHIYLATDLD 113 +G+D +++ Y +P + K + ++K KAD IYLATD D Sbjct: 40 -------LGIDIANDFAMEYSFIPDAKVNDRTFDGGEKRIEKIKAFLNKADKIYLATDPD 92 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 REGEAI+WHL+E +G +D ++ R+ FNEI++ AI++A N L+ V AQ+ARR +DR Sbjct: 93 REGEAISWHLKECLGLEDGQFERIEFNEISEKAIKEAINNGRGLDYQLVYAQEARRALDR 152 Query: 174 VVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA 233 +VGY+VSP+ + + SAGRVQS AV +VV RE EI+ F + V+ S + Sbjct: 153 LVGYLVSPMASNLMGQPSSAGRVQSPAVLIVVLREIEIQKFKVTNHFGVNLSFDKEPKKW 212 Query: 234 LALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAA 293 ++ VT + +P +++ A + + + VL +K S +PF T+ L QAA Sbjct: 213 ISQWVTTEFVTEDQPYVLDRS-LAEEVAKTKKVKVLNCTEKTEYSNAPSPFSTALLLQAA 271 Query: 294 STRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 S LGF ++T AQ L+E G ITY+RTD N++ ++V + Y +++ + LPE PN Sbjct: 272 SVALGFSPQQTTKAAQALFEQGAITYIRTDGLNIADESVEEIFAYANEH--QFSLPEKPN 329 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 ++ K+ +Q AHEAIRP V++ + L + + LYQLIW + ++ Q+ A+Y + TL Sbjct: 330 KFKEKDGAQNAHEAIRP--VHITDKDLGK-SPEQKALYQLIWERTISSQLAKAEYKAVTL 386 Query: 414 TV--GAGDFRLKARGRILRFDGWTKVMPALRKGDEDR---ILPAVNKGDALTLVELTPAQ 468 + G ++ A+ R L GW DE+ ++P + G + + Sbjct: 387 ELLSEDGKYKFHAKSRELIKKGWMVFGKDCLNEDENEPSGVVPVLEVGSVVDVESGEVIA 446 Query: 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528 TKPP R++EASL+K+LE GIGRPSTY+SI++ I ++G++ VE + K+G + Sbjct: 447 KQTKPPKRYTEASLIKKLESCGIGRPSTYSSIMANILNKGFLEVEKKVLKPTKLGNDLIG 506 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 L + ++ ++ +ME LD++A+ E + +V+ ++ Q+L A K Sbjct: 507 SLLKAKFSFLDLHYSKEMELQLDKIASGETSYNSVVSALYTQLAQELSTASK-------- 558 Query: 589 PNQMVLTSIDCPTCGRKMG--IRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVL 646 + +I CP C ++ T + F CS E CK ++N Sbjct: 559 --LTAINAIPCPKCKSQLKKFKNTKTNQFFWICSN------EDCKHSMN----------- 599 Query: 647 EGEDAETNALRAKRRCPKCGTA-MDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYD 705 +D + CPKC T ++ + ++ N+ C ++ ++ Sbjct: 600 --DDKGKPVEKVIHSCPKCKTGRLNKFQNSQTKEFFWICNDQECKHSMDDKKGQPVEKIK 657 Query: 706 GPIVECEKCGSEMH--LKMGRFGKYMACTNE--ECKNTRKILRNGEVAPPKEDPVPLPEL 761 P C KC + + K G+ C N +CK P L Sbjct: 658 YP---CPKCSTPLFRSKKEGKD-PIWFCPNRETDCKV---------FLPEVNKKPLLEVY 704 Query: 762 PCEKSDAYFVLRDGAAGVFLAANTF 786 C + + +GA G F + Sbjct: 705 SCPQCASDLRRINGANGYFWGCTNY 729 >UniRef50_A1AXT2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A1AXT2_RUTMC Length = 777 Score = 538 bits (1385), Expect = e-151, Method: Composition-based stats. Identities = 264/812 (32%), Positives = 409/812 (50%), Gaps = 103/812 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI K+LG + VKSS+GHIRD+P Sbjct: 1 MEKNLVIVESPAKAKTIEKFLGKGFSVKSSIGHIRDMPK--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 MG+D +N+ YE+ K+KVV++L++ + A+ +YLATD DREGEAIA Sbjct: 40 --------KNMGIDIENNFAPTYEITTDKKKVVADLRKAVKAAEKVYLATDEDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E + R+VF+EIT++AI A +P ++ V+AQQARR +DR+VG+ +S Sbjct: 92 WHLLEALNLPKDTP-RIVFHEITESAITHAIVEPRTVDYQLVDAQQARRIIDRLVGFEIS 150 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW+KI+ SAGRVQS +RLVVEREREI + ++V A T+ G ++++ Sbjct: 151 PVLWRKISGARSAGRVQSPVMRLVVEREREISQHITNSTYKVKAELTSEGGGLFEVKLSK 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + + ++ ++ A +V E K P PFITSTLQQ AS +LGF Sbjct: 211 EFESKKKVLD------FINAFLSANLTVTSIEKKSYKRSPKPPFITSTLQQEASQKLGFS 264 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE- 359 VK+TM +AQ LY G+ITYMRTDS LS+ A+++ I FG +Y +Y +K+ Sbjct: 265 VKQTMTLAQNLYREGFITYMRTDSFTLSEIAIDVTGQIIVKEFGSEY--HHIRRYKTKDT 322 Query: 360 NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG- 418 ++Q+AHEAIRP+ N+ S+ +E A KLY LI+++ +ACQM+ A+ T + + Sbjct: 323 SAQKAHEAIRPT--NLTKPSIFGIEDQAAKLYSLIYKRTLACQMSDAQLQKTQIKINISG 380 Query: 419 -DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARF 477 D + A IL F G+ +V E+++LP +NK D L+L + F++ R+ Sbjct: 381 LDEKFLANDEILTFPGFLRVYDYF--SSENKLLPDLNKEDMLSLASFKARESFSRAKPRY 438 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV------------------------- 512 +EASLVK++E+ GIGRPST+A+++ST+QDR YV Sbjct: 439 TEASLVKKIEEMGIGRPSTFATMVSTVQDRNYVTKETREGVERGYQLIEIKDNQIIQSQP 498 Query: 513 ------ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 E + + + ++TD L + F +++Y+FTA++EN D +A W+ V+ + Sbjct: 499 SEVTGAEKNKLFPTNVAYLLTDFLVKYFNNIIDYEFTAKLENDFDAIATQNISWQGVVKN 558 Query: 567 FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG----- 621 F++ F ++++ A + + P G+ + +R G F Sbjct: 559 FYTPFHKKIEDAA----DISREETHGMRELGTDPKSGKLVSVRFGRYGAFAQIGHKDDED 614 Query: 622 ---YALPPKERCKTTINLVPENEVLNVL----EGEDAETNALRAKRRCPKCGTAMDSYLI 674 +A +I L E+ N+ E +D T R P Y+ Sbjct: 615 KPIFASLRDSLDIESITLDEALELFNMPRTVGETDDFGTIKANYGRFGP--------YIE 666 Query: 675 DPKRKLHVCGNNPTCDGYEIEEGEFRIKG-YDGPIVECEKCGSEMHLKMGRFGKYMACTN 733 K+ + + + P E K +D + S + + GRFG Y+ N Sbjct: 667 YDKKYVSLKEDIPEKVSLEKALELIAYKEKFDAERIIKTFDDSNIKVLKGRFGPYIW--N 724 Query: 734 EECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 + K + + ++PV L C+K Sbjct: 725 GKKKGKGQKNITIKKVFGNKNPVDLTLKECKK 756 >UniRef50_A8II62 DNA topoisomerase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8II62_CHLRE Length = 772 Score = 536 bits (1382), Expect = e-151, Method: Composition-based stats. Identities = 251/796 (31%), Positives = 366/796 (45%), Gaps = 102/796 (12%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +V+VESP KAK I +LG Y V +S GH+RDLP +A + + + Sbjct: 1 VVVVESPTKAKKIQGFLGDKYKVLASYGHVRDLPPKAGSAAAAGVAGEEE---------- 50 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +W ++VL ++E+ A A + LATD DREGEAI+WH+ Sbjct: 51 -------------DWYLDWQVLDVARPRMAEIAGAATGAPLLVLATDPDREGEAISWHIS 97 Query: 125 EVIGGDDAR-----YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 + + R+ F EITK+A+ A +++ V+A +ARR +D +VG+ + Sbjct: 98 QELEKRGVLRKVGGVQRITFTEITKSAVTNALAAGRQVSQPLVDAYRARRALDYLVGFQL 157 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA------ 233 SP+LW+K+ SAGRVQSVA+RLV ERE I+AF P +W + A PS A Sbjct: 158 SPVLWRKLPGARSAGRVQSVALRLVCEREAAIEAFNPLAYWSIAAMLAPPSRGAAAAAAA 217 Query: 234 ---------LALQVTHQNDKPF---RPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 + ++TH + + ++ + + ++ +V + PG Sbjct: 218 AAAGPTAALIRSRLTHADGRRLGGMDIRSQAEAEELARRIQSGPVTVARVVVRQQQRHPG 277 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-------GYITYMRTDSTNLSQDAVNM 334 APF TSTLQQ AS RLGF +TM +AQ+LYE G ITYMRTD ++S +AV Sbjct: 278 APFTTSTLQQEASRRLGFSAARTMRVAQQLYEGAGVCTGEGLITYMRTDGVSISAEAVAE 337 Query: 335 VRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLY 391 +R + FG+ +P P Y S+ +N+QEAHEAIRP+ + S ++ D LY Sbjct: 338 LRAANAAMFGRGCVPPQPRWYKSRAKNAQEAHEAIRPTRPAAVTPSSLPAALDPDQAALY 397 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRL--KARGRILRFDGWTKVMPALRKGDEDRI 449 LIWR+ VA QMT A YD ++ A RL +A GR+LR G+ + + + Sbjct: 398 DLIWRRAVASQMTSAAYDVVSVEFEADGGRLGLRASGRVLRDPGYLRAYNDDEPAEGEEP 457 Query: 450 LPAV-------------NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPST 496 P + L +L QH T+PP RF+EASLV+ LE+RGIGRPST Sbjct: 458 APEAEAAGGGEDEGAAARENQGLAAQQLLALQHATRPPPRFTEASLVRALEERGIGRPST 517 Query: 497 YASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 YA I++ +QDRGYV E R +G ++T LE F ++YDFT+ ME LD VA+ Sbjct: 518 YAPIMTLLQDRGYVCREGRALLPTSLGRVLTSFLEHYFATWVDYDFTSDMEGRLDDVASG 577 Query: 557 EAEWKAVLDHFFSDF------TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCG-RKMGIR 609 +A W+ VL F+ F + + G CP CG ++ ++ Sbjct: 578 KAAWRRVLSAFWGPFQAAVGSMAAIRTTQPPGAPGAAAGPAPQRDPRRCPKCGVGRLVLK 637 Query: 610 TASTGVFLGCSGYALPPKERCKTTINLVPENE----------VLNVLEGEDAETNALRAK 659 + G F+GCS +A + C L+P L G +T Sbjct: 638 PSRYGGFIGCSNFADEALQ-CDFARPLLPSEGADGGSCVPFNATERLLGSHPDTGQPVYV 696 Query: 660 RRCP-----KCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC 714 R P + G A K + E + + Sbjct: 697 RLGPYGLYVQAGDAPKKEPKKKKTGFTI--------QSVTLEAALALLALPRTLGLHPGD 748 Query: 715 GSEMHLKMGRFGKYMA 730 G + G FG Y+A Sbjct: 749 GQPVVANTGPFGPYVA 764 Score = 45.9 bits (107), Expect = 0.006, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 29/79 (36%), Gaps = 9/79 (11%) Query: 711 CEKCG-SEMHLKMGRFGKYMACTNEE-----CKNTRKILRNGEVAPPKEDPVPLPELPC- 763 C KCG + LK R+G ++ C+N C R +L + P E Sbjct: 626 CPKCGVGRLVLKPSRYGGFIGCSNFADEALQCDFARPLLPSEGADGGSCVPFNATERLLG 685 Query: 764 --EKSDAYFVLRDGAAGVF 780 + +R G G++ Sbjct: 686 SHPDTGQPVYVRLGPYGLY 704 >UniRef50_P78032 DNA topoisomerase 1 n=2 Tax=Mycoplasma RepID=TOP1_MYCPN Length = 711 Score = 536 bits (1382), Expect = e-150, Method: Composition-based stats. Identities = 220/738 (29%), Positives = 355/738 (48%), Gaps = 71/738 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LV++ESP K KT+ KYL +D+ + S++GHIR++ ++ S + K K Sbjct: 1 MSKNLVVIESPNKVKTLQKYLPNDFEIVSTIGHIREMVHKNFGFNEADYSPVWEDWTKSK 60 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 K + L K ++ +K+ A KA +IYLATD DREGEAI+ Sbjct: 61 KKFSSLSFKG---------NLKGKKLLSKYDIIKSIKEKASKATNIYLATDPDREGEAIS 111 Query: 121 WHLREVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ +V+ D ++ R+ FNEITKNA+ A P E++ V +Q AR+ +DR++G+ + Sbjct: 112 WHVYDVLDEKDKSKCQRITFNEITKNAVLDALKNPREIDQSWVQSQFARQILDRMIGFRL 171 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS--------- 230 S LL ++ SAGRVQSVA+R + ERE+EI++FVP +W +D + Sbjct: 172 SRLLNNYLS-AKSAGRVQSVALRFLEEREQEIRSFVPRFWWTLDVLLNPKAEGVREACAN 230 Query: 231 ----------GEALALQVTHQNDKP---FRPVNKEQTQAAVSLLEKARYSVLEREDKPTT 277 AL + + +K +++ + L+ E K + Sbjct: 231 RSIPIVLREINPALRAGLKFEEEKSVSGIDFLDEASAKKFGEQLKGVFEVYNIDETKHYS 290 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQ 329 S P + + T++LQ+ A +LG+ KK ++AQ LYE I+Y RTDST LS Sbjct: 291 SSPNSAYTTASLQKDAINKLGWSSKKVTLIAQHLYEGVSINGEQTALISYPRTDSTRLSA 350 Query: 330 DAVNMVRGYISDNFGKKYLPESPNQYASKENS---QEAHEAIRPSDVNVMAESLKD-MEA 385 + YI +++G+KYL K+ Q+AHEAI P+D+N+ E +K+ ++ Sbjct: 351 QFQQSCKEYILNHYGEKYLSNRIVSAKGKKGEKIIQDAHEAIHPTDINITPEMVKNAIKK 410 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD 445 D LY+LIW + VA M K T + + A + L FDG+ K+ + Sbjct: 411 DEFLLYRLIWIRTVASLMADCKKSHTHIRFINDGNKFYASSKSLVFDGYRKIYEHFENKE 470 Query: 446 EDRI---LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 + + L + GD ++ T P AR+++ASL++ LEK IGRPSTY ++ S Sbjct: 471 SNDLYIDLDKIRVGDRFMAKDIKITARQTHPAARYTQASLIEALEKSNIGRPSTYNTMAS 530 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 DRGY + F+ ++GE V + L ++F +++N +FT ME SLD++A ++ ++ Sbjct: 531 VNLDRGYASLNKHAFHVTQLGEQVNEELSKHFGKIINKEFTKNMEKSLDEIAENKKNYQE 590 Query: 563 VLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG--VFLGCS 620 L F+S+F +++ AE + + DCP+C + R G F+GCS Sbjct: 591 FLRDFWSNFKEEVKLAEGSIQRVK---KEKEFVGRDCPSCASPLLYRYTKRGNEKFVGCS 647 Query: 621 GYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLID--PKR 678 + CK N + + CP+C + + P + Sbjct: 648 NFP-----NCKY-----------NEFSQNKPNLTLEKLEELCPECNSQLVKRRTKFNPNK 691 Query: 679 KLHVCGNNPTCDGYEIEE 696 C N P C + + Sbjct: 692 TFVGCSNFPRCRYIKKDN 709 Score = 69.7 bits (169), Expect = 4e-10, Method: Composition-based stats. Identities = 17/90 (18%), Positives = 34/90 (37%), Gaps = 12/90 (13%) Query: 710 ECEKCGSEMHLKMGRFG--KYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKS 766 +C C S + + + G K++ C+N CK + K + + C + Sbjct: 623 DCPSCASPLLYRYTKRGNEKFVGCSNFPNCKYNEFSQNKPNLTLEKLEEL------CPEC 676 Query: 767 DAYFVLRDGAA---GVFLAANTFPKSRETR 793 ++ V R F+ + FP+ R + Sbjct: 677 NSQLVKRRTKFNPNKTFVGCSNFPRCRYIK 706 >UniRef50_O34204 DNA topoisomerase 1 n=8 Tax=Thermotogaceae RepID=TOP1_FERIS Length = 699 Score = 536 bits (1381), Expect = e-150, Method: Composition-based stats. Identities = 249/694 (35%), Positives = 366/694 (52%), Gaps = 68/694 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K ++IVESPAKAKTI + LG+DY V SS GHIRDLP Sbjct: 37 KKKVIIVESPAKAKTIERILGNDYQVISSKGHIRDLPQ---------------------- 74 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + GVD ++ + +E++PGKE VV ++K+ + L +D DREGEAIAW Sbjct: 75 -------KQFGVD-LNSLKLDFEIIPGKESVVEQIKK-MTSGKEVLLPSDQDREGEAIAW 125 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL ++G + F EIT+ AI++A P E+++++VNAQ ARR +DR+VGYM+SP Sbjct: 126 HLSTILGVKGKNI--ITFTEITERAIKEAVKNPREIDMNKVNAQLARRVLDRIVGYMISP 183 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLW+ I SAGRVQS A++++ ERERE FVP+++++V L +T Sbjct: 184 LLWRIIKDARSAGRVQSAALKIICERERERYRFVPQKYFKVWIDIA-----GLKAYLTKV 238 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + K +P + + + L + +++ + K P APFITSTLQQ A+++LGF V Sbjct: 239 DGKKIKPTDITEEISKDVLQKVKSVRLVDIDVKEVRKNPPAPFITSTLQQDAASKLGFPV 298 Query: 302 KKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP- 352 KTM +AQ LYE +ITYMRTDST +S A +I NFG++YL ES Sbjct: 299 SKTMKIAQELYEGVDTKEGHTAFITYMRTDSTRVSDVAKEAAEKFILKNFGREYLNESSE 358 Query: 353 ----NQYASKENSQEAHEAIRPSDVNVMAESLKDM-EADAQKLYQLIWRQFVACQMTPAK 407 +K Q+AHE IRP DVN+ E K++ + D KLY+LIW++F+A QM+ A Sbjct: 359 VASKKGSKTKGKVQDAHECIRPVDVNITPEKAKELLDKDHHKLYELIWKRFIASQMSSAI 418 Query: 408 YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 Y + +G + +A R FDG+ KV + E + LVE A Sbjct: 419 YKQYSYDFESGKYVFEASIRERIFDGFEKVYTIDNEPSEKHK--ELKVDQEY-LVEPKSA 475 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 + T PP R++EASLVK LE GIGRPSTYA+II T+ DRGYV + + +G +V Sbjct: 476 EAQTTPPDRYTEASLVKTLEMEGIGRPSTYATIIQTLLDRGYVVKKRKTLIPTILGFVVN 535 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 LE+ F ++++ FTA+ME LD+V N + +WK V+ F +F + L++A+ + Sbjct: 536 HYLEQRFPDIVDKGFTAEMEKELDEVENGKKDWKEVVKSFLKEFNKDLERAKNEFFAIDF 595 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 T I C C ++ G++L C + ++ N++ + E Sbjct: 596 D------TDITCEDCSGNYKLKVGKYGLYLHCPNCKTNKALKSD-VFGVIDGNKLYVLEE 648 Query: 648 GEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLH 681 E E N + + +S RK + Sbjct: 649 QESQEENGEKNSV------QSEESSANSGNRKFY 676 >UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6YTB3_THEON Length = 717 Score = 533 bits (1374), Expect = e-150, Method: Composition-based stats. Identities = 177/753 (23%), Positives = 308/753 (40%), Gaps = 64/753 (8%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHI-RDLPTSGSAAKKSADSTSTKTAKKPKKD 62 L+I E P A+ I L V+ ++G + T A + + PK Sbjct: 3 TLIIAEKPNVARKIAYALAEGRPVRKTIGKVPYYEFTRDGKRIIVAPAVGHLFSLAPKTK 62 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAI 119 G V + W Y GK + + L LA++AD +A D D EGE I Sbjct: 63 TYGYPVFDI------EWVPVYVAEKGKSYAKDYIKALATLAKRADEFVVACDYDTEGEVI 116 Query: 120 AWH-LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE-LNIDRVNAQQARRFMDRVVGY 177 + L+ G D ++ R+ F+ +TK + +A+ +N +A AR +D G Sbjct: 117 GYTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNLESTINFGMADAGIARHVLDWYWGV 176 Query: 178 MVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 +S L I R LS GRVQ ++ +V+RE+EI+ F P +W + Sbjct: 177 NLSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKMVLEKNGQ 236 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + A+ + R +++ + + V +K V + + K P PF TLQ+ Sbjct: 237 QYTAVY------EKERILDENEAKRIVEEAKKGPAFVEKVDVKQQNRHPPVPFDLGTLQR 290 Query: 292 AASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD------AVNMVRGYISDNFGK 345 A + G+ KKT+ +AQ+LYE G +Y RT S L ++ N+ + F Sbjct: 291 EAYSAFGYSPKKTLELAQKLYERGLTSYPRTSSQKLPKNLNFRSILQNLAKLPEYKPFAH 350 Query: 346 KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTP 405 + L + + + AH AI P+ ++ D LY LI R+F+A M P Sbjct: 351 ELLGKERLKPVEGKKDDPAHPAIYPTGELPKP---GELTKDEANLYDLIVRRFLALFMEP 407 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELT 465 A + + + + R G +GW KV K DE ILPA +G+ + ++++ Sbjct: 408 AVREIMKVIINSNGHRFILSGARTIKEGWLKVYGKYVKFDE-AILPAFKEGEPVKVLQIK 466 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 + TKPPAR+S A+++K +E GIG +T A I+ T+ RGY+ ++ +G Sbjct: 467 REKKKTKPPARYSPAAVIKRMEDLGIGTKATRAQILETLYSRGYIE-GKKKIKVTPLGMR 525 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 V + LE N ++++ + T E ++++ +A+ V++ + L + ++ + Sbjct: 526 VVEALERNVPDIVSVELTRAFEEKMEEIMAGKADKDRVIEESKEQLIKILQQFKEKELDI 585 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 G + T + + T+ + E E +V Sbjct: 586 GKVLMETTGTGVTT------------------------SKENAKRAGTVKELSETEEKDV 621 Query: 646 LEGEDAETNALRAKRRCPKCGTAM-DSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 + + +CPKCG + Y ++ C N P C+ RI Sbjct: 622 KKTIEKGEKTPLVVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVTYPLLQRGRIIPT 681 Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTNEECK 737 + + G+ + + +Y C + CK Sbjct: 682 NKTCCD----GAPVVKIREKGREYEICLDMNCK 710 Score = 47.0 bits (110), Expect = 0.003, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 19/51 (37%), Gaps = 2/51 (3%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAA--GVFLAANTFPKSRET 792 ++ + K + PL C K V+R F+ + +PK T Sbjct: 619 KDVKKTIEKGEKTPLVVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVT 669 >UniRef50_B1VAJ5 DNA topoisomerase n=6 Tax=Acholeplasmataceae RepID=B1VAJ5_PHYAS Length = 655 Score = 533 bits (1372), Expect = e-149, Method: Composition-based stats. Identities = 225/712 (31%), Positives = 359/712 (50%), Gaps = 67/712 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K ++IVESPAK KT++++ + SS GHIRDL SG Sbjct: 1 MKKKVIIVESPAKIKTLSRFFDDKVEILSSKGHIRDLSLSGK------------------ 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +R+G+D + + YE++ K+ +V L + + I+LATD DREGEAIA Sbjct: 43 --------DRLGIDIKNGFIPKYEIIKEKKTLVESLIKKTKN-KEIFLATDPDREGEAIA 93 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +V+ + +R+VF EITK + +A P ++ V +Q+ RR +DR++G+ +S Sbjct: 94 WHLSKVLNLNPQMANRIVFREITKEVVLKALQNPRTVDELLVFSQETRRMLDRIIGFKLS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 L+ + ++ SAGRVQSVA++L+V+ E+EI +FVPEE+ + A + + Sbjct: 154 RLVRRIKSQ--SAGRVQSVALKLIVDLEKEINSFVPEEYNLITAFF-----PFFQAEYQN 206 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 N+K + + V+ + + V + + T SKP P ITSTLQQ A L Sbjct: 207 PNNKKIKS---AEALGIVAKITNKPFIVKKIKQTETFSKPKKPLITSTLQQEAINNLYMT 263 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 +TM +AQ+LYE G ITYMRTDS S+ V + I + +G+KYL + Sbjct: 264 SNQTMRVAQKLYEGIDIEGESIGLITYMRTDSPRFSEVFVKDAQKLIKEKYGQKYL--AV 321 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 + K +Q+AHEAI+P+D++ ESL ++ KLY LI+++ +A M PA + Sbjct: 322 FKQNQKNKAQDAHEAIKPTDLSKTPESLMSYLDKYEYKLYDLIYKRSLASLMKPAIFQKN 381 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + G I FDG+ K++ + +D+I+P N ++ ++ Q FT Sbjct: 382 QVFFEVEKHSFLTEGLIKTFDGYQKIL---KDNLQDKIIPTFNLNESYFPEKIETFQKFT 438 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 P ARFSEA+L+K LEK IGRPSTY+ II T++ R YV + +RF + G + LE Sbjct: 439 TPQARFSEATLIKTLEKLNIGRPSTYSQIIFTLKKRFYVDMIEKRFQPTEQGILTIQNLE 498 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 F++ ++Y +TAQME+ LD++A+ + K ++ F+++F Q A++ E+ + Sbjct: 499 LFFKQFLDYQYTAQMESDLDKIASGLVDNKQLMQTFYTNFLQLYQIADQKLEKI-----K 553 Query: 592 MVLTSIDCPTCGRK-MGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 + T C C + I+ + G FLGCS + CK T + + + Sbjct: 554 PIETDQKCNLCNEGNLLIKKSHYGSFLGCSRFP-----DCKNTSPWKVQEKNKSKDSDHS 608 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIK 702 +T+ ++C C C P C + + K Sbjct: 609 NQTD-----QKCNLCNEGNLLIKKSRYGSFLGCSRFPDCKNIVKIKNKPNSK 655 Score = 80.1 bits (196), Expect = 4e-13, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 37/104 (35%), Gaps = 3/104 (2%) Query: 692 YEIEEGEFRIKGYDGPIVECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVA 749 Y+I + + +C C + +K +G ++ C+ +CKNT + Sbjct: 542 YQIADQKLEKIKPIETDQKCNLCNEGNLLIKKSHYGSFLGCSRFPDCKNTSPWKVQEKNK 601 Query: 750 PPKEDPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRET 792 D + C + +++ G FL + FP + Sbjct: 602 SKDSDHSNQTDQKCNLCNEGNLLIKKSRYGSFLGCSRFPDCKNI 645 Score = 50.9 bits (120), Expect = 2e-04, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 28/69 (40%), Gaps = 2/69 (2%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRETRAPL 796 N ++ + + K P+ + C + +++ G FL + FP + T Sbjct: 537 NFLQLYQIADQKLEKIKPIE-TDQKCNLCNEGNLLIKKSHYGSFLGCSRFPDCKNTSPWK 595 Query: 797 VEELYRFRD 805 V+E + +D Sbjct: 596 VQEKNKSKD 604 >UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms RepID=C6CZS8_PAESJ Length = 719 Score = 531 bits (1367), Expect = e-149, Method: Composition-based stats. Identities = 170/720 (23%), Positives = 296/720 (41%), Gaps = 101/720 (14%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ AK I + LG DYVV ++GH+ L K Sbjct: 2 KSLVLAEKPSVAKEIARVLGCSSKNKSYMEGPDYVVTWALGHLVTLAEPEDYDPKYKT-- 59 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLA 109 + P + + +V+ + QL ++ D + +A Sbjct: 60 -----------------WNLEDLPLLPGKMNLKVMRETSHQYKAVAQLCKRPDIGELIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQA 167 TD REGE +A + E++ + R+ + T AI+ F KPG+ + + Sbjct: 103 TDAGREGELVARWIMELVHWR-KPFKRLWISSQTDKAIKDGFKALKPGQQYNNLYASAVC 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D ++G V+ L K L+AGRVQ+ + +++RE+EI F + +W V A Sbjct: 162 RAEADWLIGLNVTRALTVKYNAQLAAGRVQTPTLGALIDREKEINQFQSQPYWTVSAELG 221 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 A ++ R ++ + +A ++ L+ V + + F + Sbjct: 222 -----AFQALWRQNDNHDGRVWDRSEAEAVIARLQGKSAKVDKLRTTQKSEPHPQAFDLT 276 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 LQ+ A+ RLGF K T + Q+LYE +TY RTDS LS D V ++G + Sbjct: 277 ELQREANKRLGFSAKMTSNVLQKLYEQHKLVTYPRTDSRYLSSDIVPTLKGRLESVAVGP 336 Query: 347 YLPESPN---------QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 Y P + + ++ H AI P+D V +L + D +KLY LI R+ Sbjct: 337 YAPLARKLLRGQLTVTKRFVDDSKVSDHHAIIPTDEYV---NLSALSNDERKLYDLIVRR 393 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR------KGDED---- 447 F+A P YD T++ + G +L A+G++ + GW ++ + DE+ Sbjct: 394 FIALFYPPYTYDETSVVLTVGQDKLYAKGKVQKDIGWKELYGGSDARFTADEDDEEENGR 453 Query: 448 --------RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYAS 499 ++LP + +G A+ + + + T PPAR++EASL+ ++EK G+G P+T A Sbjct: 454 GEDKSTPEQLLPELVQGQAVQVKQSRLKELRTLPPARYTEASLLSKMEKHGLGTPATRAD 513 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 II + + R G+ + + + + EL + + TA+ E L+ +A+ + + Sbjct: 514 IIEKLLSTDTIERTQNRLVPTSKGKQLIELVVD---ELRSPELTAKWERELELIAHGQGD 570 Query: 560 WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC 619 K + + + + + +E LT CP CG+ + G L C Sbjct: 571 AKRFMAGIREQANKWVTAVKNETKEYKPH----NLTHSRCPECGKLLMEVKGKRGKSLVC 626 Query: 620 SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRK 679 S C P + +RCP+C M+ + + Sbjct: 627 S------DRECSYRRQAEP-----------------ALSNKRCPQCHKKMEIHNGKAGKY 663 Score = 55.1 bits (131), Expect = 1e-05, Method: Composition-based stats. Identities = 16/92 (17%), Positives = 31/92 (33%), Gaps = 12/92 (13%) Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPP 751 ++ K ++ C +CG + G+ GK + C++ EC R+ Sbjct: 587 TAVKNETKEYKPHNLTHSRCPECGKLLMEVKGKRGKSLVCSDRECSYRRQAEP------- 639 Query: 752 KEDPVPLPELPCEKSDAYFVLRDGAAGVFLAA 783 L C + + +G AG + Sbjct: 640 -----ALSNKRCPQCHKKMEIHNGKAGKYAQC 666 >UniRef50_C6XEP4 DNA topoisomerase I n=1 Tax=Methylovorus sp. SIP3-4 RepID=C6XEP4_METSD Length = 590 Score = 529 bits (1363), Expect = e-148, Method: Composition-based stats. Identities = 242/643 (37%), Positives = 337/643 (52%), Gaps = 60/643 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP KAK +++YLGS+Y+VK+S GH+RDLPTS Sbjct: 1 MSKTLIIVESPTKAKKLSEYLGSEYLVKASFGHVRDLPTSNG------------------ 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +G P +E YEV + LK ++ D + LATD DREGEAI+ Sbjct: 43 ---------EIGYHPE-TFEPIYEVTEKARTTIKVLKAAVKECDRVLLATDPDREGEAIS 92 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E++G RV F+EIT +AI +A N P ++ V AQ+ARR +DR VG++VS Sbjct: 93 WHLAELLGLRKR--ERVKFHEITASAILKAINTPSAIDTSLVRAQEARRIIDRQVGWLVS 150 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 L +KI + SAGRVQS A+ LVVEREREI AF E F+ V+A + G Sbjct: 151 GPLTRKIGQRASAGRVQSPALALVVEREREILAFKKEAFFTVEAEFSEEWGAVWPSDEQQ 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 D+ A ++ E ++SVLE + P PF TS L QAAS LGF Sbjct: 211 CKDRSV----------AETIAESKQFSVLEYDLSKLHEDPPPPFRTSKLLQAASVVLGFD 260 Query: 301 VKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE 359 K+TM +AQ L++ G I+Y RTD +N+S DA M+ Y + + + Sbjct: 261 PKRTMDLAQSLFQKHGAISYHRTDESNISDDAYGMIVEYGQER--NYPMSSEKRTWKGVV 318 Query: 360 NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG- 418 +QEAHEAIRPSD+N + + M AD LY+LI + VA QM PA+Y T T+ Sbjct: 319 AAQEAHEAIRPSDMNYQPD--ETMTADEAALYRLIHSRAVASQMEPAEYTVATATLSNEQ 376 Query: 419 DFRLKARGRILRFDGWTKVMPALRKGDEDRIL---PAVNKGDALTLVELTPAQHFTKPPA 475 + KA+ + L GW + + D++ L P ++ G L +T +H T+PP Sbjct: 377 GIKFKAQSKSLCKPGWRVLAVQDEEHDDNPSLSHIPDLSVGQILHSSNVTVCEHSTRPPK 436 Query: 476 RFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFR 535 R+++ASL LE+ GIGRP+TYAS++ + DR YV+V R E +G + D L+ F Sbjct: 437 RYTKASLTNALERLGIGRPATYASMVDGLTDRSYVQVVERFLTPEPVGFAIYDALKGAF- 495 Query: 536 ELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLT 595 + ++T ME+ LD + + +++V+ +SD T +L G P T Sbjct: 496 SFIETEYTRGMESDLDLIVKGDKTYRSVVSSKYSDLTTELASF-----GGAEIPRPAPST 550 Query: 596 SIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVP 638 CP CG+ M RT S G FLGCSGY +CK T L Sbjct: 551 VGSCPKCGKGMVQRTGSRGPFLGCSGYP-----KCKETQQLPK 588 Score = 67.4 bits (163), Expect = 2e-09, Method: Composition-based stats. Identities = 14/41 (34%), Positives = 19/41 (46%) Query: 754 DPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 P P C K V R G+ G FL + +PK +ET+ Sbjct: 545 RPAPSTVGSCPKCGKGMVQRTGSRGPFLGCSGYPKCKETQQ 585 Score = 52.0 bits (123), Expect = 1e-04, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 23/51 (45%), Gaps = 1/51 (1%) Query: 697 GEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNG 746 G + + C KCG M + G G ++ C+ +CK T+++ + Sbjct: 540 GAEIPRPAPSTVGSCPKCGKGMVQRTGSRGPFLGCSGYPKCKETQQLPKGA 590 >UniRef50_B7KK14 DNA topoisomerase n=4 Tax=Cyanobacteria RepID=B7KK14_CYAP7 Length = 720 Score = 526 bits (1354), Expect = e-147, Method: Composition-based stats. Identities = 234/745 (31%), Positives = 377/745 (50%), Gaps = 78/745 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L ++E+P K K + + LGS+Y+VK+S GHIR+L G D KK Sbjct: 1 MSKKLFLIEAPGKLKKLQQILGSEYIVKASGGHIRELAKDG-------DDNLGFDLKKDS 53 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 R N P K +S+LK+LA + D + LATD DREGE IA Sbjct: 54 ISCRFMPKN-----------------PMARKTISQLKELARQVDTVILATDEDREGEIIA 96 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+EV+ + R+ + EIT A++ + N+P L+++ VNA AR +D++VG+ S Sbjct: 97 WHLKEVLNLRNP--QRITYREITPAAVKASLNRPRSLDMNLVNAALARSVLDKLVGFRGS 154 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS-------------TT 227 PL+WK S GRVQS A+ ++ +REREI+ F P+++W V + T+ Sbjct: 155 PLVWKLGNGAKSIGRVQSAALHILCQREREIQEFKPQDYWLVSVTYSEGFKAYYLGEKTS 214 Query: 228 TPSGEALALQVTHQNDKPF------RPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 TP+ + Q +K + +++ + VSL + + V+E + K + P Sbjct: 215 TPTDKEENEQRDDAGEKEENKVEATKVLSEAEADRLVSLARQFPHHVIEVQSKTVSKNPP 274 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 APF TS+LQQAA +RL + KTM +AQRLYE GYITYMRTDS +L V+ ++ Sbjct: 275 APFTTSSLQQAAGSRLKWSPDKTMQVAQRLYEGGYITYMRTDSYHLDPQFCATVKQWLQQ 334 Query: 342 NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVA 400 +P + + + +QEAHEAIRP+D+ + LK ++ A+ +LY LIW + VA Sbjct: 335 K-DPNNIPVKVASHRTSKTAQEAHEAIRPTDIFKPSIELKQEISAEEFELYLLIWLRTVA 393 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALT 460 Q A+ T + +GD +ARG+I+ F G+ K + +D +LP V+ G L Sbjct: 394 SQCKSAQILKTRIITQSGDIFWQARGQIVTFAGYAKYW---KDLSDDLLLPQVSGGQLLN 450 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 L E + T+PP R+SEA LV+ +E+RGIGRPST+A + T+++RGY +V+ R+ A Sbjct: 451 LSEAGHEKKQTQPPPRYSEAKLVQVMERRGIGRPSTFAPTVKTLKERGYAQVQKRQLQAT 510 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL-----DHFFSDFTQQL 575 +G V L++ EL+ +FTA ME+ LD +A+ + W+ + D+F + L Sbjct: 511 PLGLEVDAFLQKTLPELLQAEFTALMEDKLDAIASGKENWERYIIGWNEDYFAVALLKAL 570 Query: 576 D------KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV-----FLGCSGYAL 624 + K+ + + + + I+CP C KM + + FL C Sbjct: 571 KVVGSQASSSKNSQSLEAKGHSNKESKINCPHCSHKMLEIPSKSKKLHKDYFLKCPS--- 627 Query: 625 PPKERCKTTINLVPENEVLNVL--EGEDAETNALRAKRRCPKCGTAM--DSYLIDPKRKL 680 C+ + ++ + + +++ + + CP CG + Y + +K Sbjct: 628 -----CQAVMFYNKWRKIWELPGEKSQESTPSLKLTQHSCPVCGEKLAVREYEKEGVKKQ 682 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYD 705 + ++P G + + + + Sbjct: 683 MLVCSSPKAKGDKKHKEVVYFESKN 707 >UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF5_DESAS Length = 721 Score = 524 bits (1349), Expect = e-147, Method: Composition-based stats. Identities = 165/730 (22%), Positives = 285/730 (39%), Gaps = 107/730 (14%) Query: 3 KALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ A+ I + L G+ Y+V ++GH+ L +K Sbjct: 2 KSLVLAEKPSVAREIARILNCTIKGKGYLEGNKYIVTWALGHLVTLAEPEDYDEKYKTWR 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLA 109 + P E V+ + +L ++ D + +A Sbjct: 62 TEDLPMLPA-------------------EMKTVVIKKTGPQFHIVSKLMKRPDVRELIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQA 167 TD REGE +A + + + R+ + +T AIR+ F + PG + ++ Sbjct: 103 TDAGREGELVARWIMKQARC-QKPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAIC 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D ++G V+ L K LSAGRVQ+ + ++V RE+EIK FVP +FW V A+ Sbjct: 162 RAEADWLIGLNVTRALTVKYNAQLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANLG 221 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + ++ K R + Q + V+ +++ V++ + + +P + + Sbjct: 222 K-----FQAEWRDKSGKHNRFSDCLQAETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLT 276 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVR---GYISDNF 343 LQ+ A+ + G+ +KT+ Q LYE +TY RTDS L+ D V + +S + Sbjct: 277 ELQRDANKKFGYTAQKTLAGLQMLYERHKLVTYPRTDSRYLTSDMVPTLMPRLKAVSGGY 336 Query: 344 GKKYL------PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 + + P N+ + H AI P+ +L + A+ + +Y LI R+ Sbjct: 337 FAELVKPLTAKPLPINKRLVDNSKVTDHHAIIPTTER---ANLAALTAEEKNIYDLIVRR 393 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE-------DRIL 450 F+A Y TT+ V A G+++ GW V + + ++ L Sbjct: 394 FIAVFYPAYSYKQTTVIVLIAGEHFHASGKVVTNPGWKAVYNNESREKDTGYDDTPEQNL 453 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRP 494 P + KGD + ++ + TKPPAR++EASL+ +E + G+G P Sbjct: 454 PPLKKGDKVKVLSCKSVKGQTKPPARYTEASLLSAMEHPGKFIEDEILKESVKESGLGTP 513 Query: 495 STYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 +T A II I YV + G + + + EL D TA+ E L +A Sbjct: 514 ATRAEIIEKIISSNYVERRGKELIPTAKGIQLVELVP---PELKQADLTAKWEQQLHDIA 570 Query: 555 NHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG 614 +++ F S + +K +T CP C + + G Sbjct: 571 MGKSKR----TKFISGIREHAEKIVTTVLNSSSTFKPDNVTGNKCPKCRKFLLSVKTKRG 626 Query: 615 VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLI 674 L C + ++ K T + R CP+C Sbjct: 627 SNLVCPDRSCGHRQVEKET------------------------SNRPCPQCKKRRMEIRE 662 Query: 675 DPKRKLHVCG 684 K+ VC Sbjct: 663 GKGGKIIVCT 672 Score = 42.8 bits (99), Expect = 0.056, Method: Composition-based stats. Identities = 12/96 (12%), Positives = 25/96 (26%), Gaps = 14/96 (14%) Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPP 751 + K + +C KC + + G + C + C + + Sbjct: 592 TTVLNSSSTFKPDNVTGNKCPKCRKFLLSVKTKRGSNLVCPDRSCGHRQVEKET------ 645 Query: 752 KEDPVPLPELPCEKSDA-YFVLRDGAAGVFLAANTF 786 PC + +R+G G + Sbjct: 646 -------SNRPCPQCKKRRMEIREGKGGKIIVCTHC 674 >UniRef50_B7J7I8 DNA topoisomerase I, putative n=1 Tax=Acidithiobacillus ferrooxidans ATCC 23270 RepID=B7J7I8_ACIF2 Length = 705 Score = 524 bits (1349), Expect = e-147, Method: Composition-based stats. Identities = 221/699 (31%), Positives = 327/699 (46%), Gaps = 68/699 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP KA I LGS + VK++VGHIRDLP G AA Sbjct: 1 MTK-LLIVESPTKAHHIQAMLGSGWSVKATVGHIRDLPIKGDAAYVRPP----------- 48 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +++ +YE+ K V L+ A A+ +Y+ATD DREGEAIA Sbjct: 49 -----------------DFKLNYEITERASKTVPALRAAARDAESVYIATDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ +V+G RV + E+T+ AIR+A P +N+ V AQ+ARR +DR+VG+ VS Sbjct: 92 WHVCQVLGIKPGAAKRVTYQEVTEPAIRKAIAAPRTVNMPLVAAQEARRALDRIVGWEVS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG--EALALQV 238 L I SAGRVQ+ A+ LVV RE+ I+ F P +++V A + A+ V Sbjct: 152 GPLSNAIGSRASAGRVQTPALSLVVAREQAIRQFKPTPWFQVLAHVAGKDAAPDWRAVWV 211 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 + + +K +A L V + E KP P PF TS++Q + L Sbjct: 212 DGTQEGEY-FQDKAHAKALADALPSMALKVTKAETKPVRKPPAPPFTTSSMQMDGARALK 270 Query: 299 FGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK 358 V M AQ L+E G+ITY RTDS NLS++ ++R + L E+P ++ SK Sbjct: 271 APVDAIMKAAQSLFEHGHITYHRTDSPNLSEEGEGLLRAALKKE--NLPLVETPRRWRSK 328 Query: 359 ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG 418 +QEAHEAIRP+ V D+ Q LY LI ++ +A QM A Y T+ T+ G Sbjct: 329 GGAQEAHEAIRPTRPMVRQAGENDL---EQALYDLIRKRALASQMPDAVYQQTSCTLDGG 385 Query: 419 DFR-----LKARGRILRFDGWTKVMPALRKGDED------RILPAVNKGDALTLVELTPA 467 F+ +A G +L+ GW + + +E +P + GDA+ Sbjct: 386 MFQGRPAVFRAVGSVLKDPGWMALYRETAEDEEGTENPAANPVPRLAVGDAVRAARGECL 445 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR--FYAEKMGEI 525 TK P R++E++L+K LE G+GRPSTYASI+ + R Y+R + + YA ++GE Sbjct: 446 SKTTKAPPRYTESTLIKALEDHGVGRPSTYASILKNLFAREYIRRKGKSPALYATELGEK 505 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 + + L + + N D+T ++E LD++ + + +L F+D + LD Sbjct: 506 IVEAL--SVFDFSNVDYTREVEADLDRITEGQMRPRDLLAKSFADIQRILDAMPTQARAQ 563 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 G RP + R++ + F CS P + P E + Sbjct: 564 G-RPCPIEGCDGTV----RRLESKRKPGVFFWMCSNRDAHPLLQDNDGEPGAPFAERVEA 618 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCG 684 +G CP+CG A CG Sbjct: 619 GDGP-----------ACPECGAATSRQETGKGYGYFRCG 646 >UniRef50_Q8EVZ3 DNA topoisomerase n=1 Tax=Mycoplasma penetrans RepID=Q8EVZ3_MYCPE Length = 707 Score = 523 bits (1347), Expect = e-146, Method: Composition-based stats. Identities = 235/754 (31%), Positives = 371/754 (49%), Gaps = 76/754 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+I+ESP K KT+ KYLG DY + +++GHIRDL G D+ P Sbjct: 1 MDK-LLIIESPNKIKTLTKYLGKDYEIIATIGHIRDLNQFGMGF----DADFEPKWVIPS 55 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + N + K+++V +LK+ A KA IY+ATD DREGEAIA Sbjct: 56 VKKNSKNKNEV----------------SKKEIVEKLKKSASKAKEIYIATDPDREGEAIA 99 Query: 121 WHLREVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ EV+ + R+ FNEITKNAI ++ N +++I+ V +Q ARR +DR++G+ + Sbjct: 100 WHVYEVLDAASQKKCKRITFNEITKNAILESLNHKRDIDINWVQSQFARRIIDRLIGFKL 159 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT----------P 229 S LL K+ + SAGRVQSVA++ + +RE+EI+ FV E +W +D P Sbjct: 160 SKLLQTKL-KADSAGRVQSVALKFIEDREKEIRNFVAENWWTLDVMLEDNNSLILKSIDP 218 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP-TTSKPGAPFITST 288 + + + L + ++E ++ L+K ++ V E+ +S P +P+ TST Sbjct: 219 NLKNIKLSEKKFSTSGLDIADEESANNLLNALDK-KFKVKSIEEPSFYSSYPKSPYKTST 277 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYIS 340 LQQ A +LG+ KK ++AQ LYE I+Y RTDS LS V +I Sbjct: 278 LQQDAINKLGWNSKKITLIAQHLYEGVEVDGNQIALISYPRTDSLRLSDTFVQSAFKFIE 337 Query: 341 DNFGKKYLPE-SPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQF 398 + +GK Y+ + A+ N+Q+AHEAIRP D + + LK + D LYQLI+ + Sbjct: 338 ETYGKDYVGKYQVKSSANDANTQDAHEAIRPIDPYLTPQELKNKISKDEFALYQLIYNRT 397 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI--LPAVNKG 456 VA M AK+ T+ + R F G+ K+ + +E+++ L G Sbjct: 398 VASLMAAAKFKKVTIKFDNNNCEFYTFSRECLFLGFKKLYVEDNEDEENKLIDLNNYPVG 457 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 + +H T+PP R+++A+L+ +LE G+GRPSTY+S+ + +RGY + + Sbjct: 458 KEFKSKVMEVKKHETQPPQRYTQATLIGDLESAGVGRPSTYSSMANIALERGYAVTDKKA 517 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 + +G+IV D+LE+ F +++N DFT +ME LDQ+A+ EWK+ L F F +++ Sbjct: 518 YVMTDIGKIVVDQLEKFFPDIINKDFTKKMEEHLDQIASGNEEWKSWLKKFAPGFDEEVK 577 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG--VFLGCSGYALPPKERCKTTI 634 KA E+ +CP CG+ + + A G F+GCSGY C Sbjct: 578 KAYDTMEKISDEK-----VGRECPKCGKDLLYKRARRGGSKFIGCSGYP-----ECTH-- 625 Query: 635 NLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEI 694 + + CP+CG+ + ++ C + P C+ Y I Sbjct: 626 --------------LEPLEKPEELEISCPECGSKLLKRKSKRQQVFVGCSSWPKCN-YII 670 Query: 695 EEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKY 728 + F + P ++ R K+ Sbjct: 671 SDKLFDKHMKETPDKPLPSKKELEEIRAARLPKW 704 Score = 64.7 bits (156), Expect = 1e-08, Method: Composition-based stats. Identities = 19/89 (21%), Positives = 37/89 (41%), Gaps = 15/89 (16%) Query: 710 ECEKCGSEMHLKMGRFG--KYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKS 766 EC KCG ++ K R G K++ C+ EC + + + E+ + C + Sbjct: 594 ECPKCGKDLLYKRARRGGSKFIGCSGYPECTHLEPLEKPEELE-----------ISCPEC 642 Query: 767 DAYFVLRDGAAG-VFLAANTFPKSRETRA 794 + + R VF+ +++PK + Sbjct: 643 GSKLLKRKSKRQQVFVGCSSWPKCNYIIS 671 >UniRef50_B1AJN1 DNA topoisomerase I n=15 Tax=Ureaplasma RepID=B1AJN1_UREP2 Length = 681 Score = 523 bits (1346), Expect = e-146, Method: Composition-based stats. Identities = 209/726 (28%), Positives = 346/726 (47%), Gaps = 76/726 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L++VESP K K+I YLG Y V ++ GH+R+L K+ D K Sbjct: 5 MQKDLIVVESPNKIKSIQSYLGDSYNVIATCGHLRELAKKSGYDPKTYDLKWEIIKTTNK 64 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 K K++ + + LA+K+++IYLATD DREGEAI+ Sbjct: 65 KL-------------------------SKKQQIKTIIDLAKKSNNIYLATDPDREGEAIS 99 Query: 121 WHLREVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ +++ D R R+ FNEIT+ AI ++ ++ +++ + V++Q ARR +DRV+GY + Sbjct: 100 WHVYDLLPKKDKERVKRITFNEITQKAILKSIDEKHDIDFNLVDSQFARRILDRVIGYKL 159 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD--------ASTTTPSG 231 S L+ K + GLSAGRVQS+A+ VVERE E ++FV EE+++++ S Sbjct: 160 SGLVKKNLH-GLSAGRVQSIALLFVVERELERRSFVKEEWYQIEGIIEKNIFVSLRKIPY 218 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED-KPTTSKPGAPFITSTLQ 290 + +D + ++K+ Q + L + V +D K T P T L Sbjct: 219 DVELYNQKDNSDSDLKFLHKKDAQRVIDDLSDI-FKVYSIDDLKITKGDVQLPLTTDKLL 277 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 Q AS G+ KT ++AQ+++E ITY RTDS LS D + +I +N Sbjct: 278 QIASNNFGWSANKTTLIAQQMFEGLEINNQQLALITYPRTDSERLSDDFLQEANAFIENN 337 Query: 343 FGKKYLPESPNQYASKE--NSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFV 399 FGK+YL N+ +++ N Q+AHEAIRP D+N+ E +KD + D KLY L+W + + Sbjct: 338 FGKEYLENFKNKKINRKEVNIQDAHEAIRPVDINLKPEEIKDYVSLDIYKLYNLVWNKTL 397 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE-DRILPAVNKGDA 458 + M ++ + +++ + +R G+ + ++ DE + P +N GD Sbjct: 398 SALMKVPTFNKQVIRFINNEYKFYTAYKTIRTLGYWILDFYKKQRDELEFQPPIINVGDE 457 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFY 518 ++ Q T PP ++EASL+ L+ G+GRPSTYA++ + RGY+ + + Sbjct: 458 FKKEKIDLIQKETTPPPYYTEASLIAALKNAGVGRPSTYATMATIGTTRGYINKDKSKLI 517 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 ++G V L+E F ++++ FT++ME LD +AN + WK ++ F F +++ +A Sbjct: 518 PTELGIKVIQELKEAFPKVISIKFTSEMEERLDVIANGKLFWKDLVSTFIPIFEEEVKQA 577 Query: 579 EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAS-TGVFLGCSGYALPPKERCKTTINLV 637 E+ + CP C + I+ + F+ CS + C+ T +L Sbjct: 578 YTKIEKVPDEKINRL-----CPICAHDLLIKRSRMNTRFIACSNFPT-----CRFTESL- 626 Query: 638 PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEG 697 CP C ++ + C P C+ + Sbjct: 627 ---------------EKPEILNELCPNCSKSLVKRKNRKNKYFIGCTGYPECNFIRNLDE 671 Query: 698 EFRIKG 703 K Sbjct: 672 SNNDKN 677 Score = 62.8 bits (151), Expect = 5e-08, Method: Composition-based stats. Identities = 15/86 (17%), Positives = 29/86 (33%), Gaps = 14/86 (16%) Query: 711 CEKCGSEMHLKMGR-FGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA 768 C C ++ +K R +++AC+N C+ T + + + C Sbjct: 593 CPICAHDLLIKRSRMNTRFIACSNFPTCRFTESL-----------EKPEILNELCPNCSK 641 Query: 769 YFVLRDGAAGV-FLAANTFPKSRETR 793 V R F+ +P+ R Sbjct: 642 SLVKRKNRKNKYFIGCTGYPECNFIR 667 Score = 60.9 bits (146), Expect = 2e-07, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 34/110 (30%), Gaps = 8/110 (7%) Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF 699 E + + + + R CP C + + C N PTC E E Sbjct: 571 EEEVKQAYTKIEKVPDEKINRLCPICAHDLLIKRSRMNTRFIACSNFPTCRFTESLEKP- 629 Query: 700 RIKGYDGPIVECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGE 747 + C C + + R K ++ CT EC R + + Sbjct: 630 -----EILNELCPNCSKSLVKRKNRKNKYFIGCTGYPECNFIRNLDESNN 674 >UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms RepID=A0LAP8_MAGSM Length = 744 Score = 523 bits (1346), Expect = e-146, Method: Composition-based stats. Identities = 167/776 (21%), Positives = 283/776 (36%), Gaps = 120/776 (15%) Query: 4 ALVIVESPAKAKTINKYLGS-----DYV------VKSSVGHIRDLPTSGSAAKKSADSTS 52 L + E P++ + I + LG+ YV V +GH+ ++ + Sbjct: 2 ILYLCEKPSQGRDIGRVLGATSRHEGYVAGAGVCVTWCIGHLMEMVAPDGYRPE------ 55 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 R+ P + E+ K ++ L + + LATD Sbjct: 56 -------------WKSWRLDTLPIIPQQWQLELTARGRKQFKVIQGLLKGVTEVVLATDA 102 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRF 170 DREGE I + E + SR+ + + +IR+A PGE A R Sbjct: 103 DREGETIGREVLERCQ-YRGKISRLWLSALDDASIRKALGNLLPGEQTEPLYQAGLGRSR 161 Query: 171 MDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 D +VG ++ +G LS GRVQ+ ++LVV+R+R I+ F P +++E+ A Sbjct: 162 ADWMVGMNLTRAYTLLGRQGGYAGVLSVGRVQTPTLKLVVDRDRLIENFKPVDYFEIFAL 221 Query: 226 TTTPSGEALALQVTHQN--DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 SG +A V D +++ + + ++ ++ + E K P P Sbjct: 222 HRVHSGTFIAKWVPPPKPCDAEGHCLDRTLAETVIHKVQGHSGTITKAETKRVKEPPPLP 281 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDN 342 STLQQ AS R G G K+T+ +AQ LYE +TY RTD L + + Sbjct: 282 LELSTLQQEASRRWGMGAKQTLEIAQSLYEKHKAVTYPRTDCRYLPSNQFKEAPAVLQGL 341 Query: 343 FGK--------KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 + A + AH AI P+ + ++ + + LY LI Sbjct: 342 TTNDASLTPLVEGADAQLRSKAWNDKKITAHHAIIPTAAKI---NIDALSREEALLYDLI 398 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG----DEDRIL 450 R ++A P +YD T + A GR+ GW +V+ A ++ ++++ L Sbjct: 399 RRHYLAQFYPPFEYDRTVIDTQVAMETFHATGRVELIPGWKRVLAANQEKKEGDEDEQTL 458 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGR 493 P V G+A T+ Q TKPP R++E +L++ + E GIG Sbjct: 459 PVVRSGEAATIEGAELKQKQTKPPNRYTEGTLIQAMKSVGKLVEDARLRKILRETSGIGT 518 Query: 494 PSTYASIISTIQDRGYVRVENRR-FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 +T A+I+ T+ R + + ++ + G ++ D L + + TA E +LD Sbjct: 519 EATRAAILETLIKRNLLAKQGKKSLVSMPAGRLLVDALPH---SVTDPATTAVWEQTLDD 575 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG--------------------------- 585 +A+ + L + + + + G Sbjct: 576 IAHGGGSLETFLAKSELWLNKLIHNVHQRQQLGLNPFRGLPPSTSHTDPAQPTPRRQRRS 635 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 + CP CG M R + G F C+ + C T P + Sbjct: 636 KAEVTPTPNAAPLCPQCGGPMLQRKSPQGAFWSCA-----EQATCTGTRPGSPLAAHSPL 690 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRK-----LHVCGNNPTCDGYEIEE 696 ++ CPKC A + K C P C + + Sbjct: 691 MQPNPERGP------LCPKCQQAPLVQRTAYRGKNSGQPFWGCQRYPQCRYTQASQ 740 Score = 76.3 bits (186), Expect = 4e-12, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 34/105 (32%), Gaps = 8/105 (7%) Query: 697 GEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEE-CKNTRKILRNGEVAPPKEDP 755 + + C +CG M + G + +C + C TR + P P Sbjct: 635 SKAEVTPTPNAAPLCPQCGGPMLQRKSPQGAFWSCAEQATCTGTRPGSPLAAHS-PLMQP 693 Query: 756 VPLPELPCEKSD-AYFVLRDGAAG-----VFLAANTFPKSRETRA 794 P C K A V R G F +P+ R T+A Sbjct: 694 NPERGPLCPKCQQAPLVQRTAYRGKNSGQPFWGCQRYPQCRYTQA 738 Score = 47.8 bits (112), Expect = 0.002, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 18/61 (29%), Gaps = 2/61 (3%) Query: 739 TRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR--APL 796 + R + + P P C + + R G F + TR +PL Sbjct: 625 AQPTPRRQRRSKAEVTPTPNAAPLCPQCGGPMLQRKSPQGAFWSCAEQATCTGTRPGSPL 684 Query: 797 V 797 Sbjct: 685 A 685 >UniRef50_A3BAP2 DNA topoisomerase n=6 Tax=Poaceae RepID=A3BAP2_ORYSJ Length = 1180 Score = 522 bits (1344), Expect = e-146, Method: Composition-based stats. Identities = 234/833 (28%), Positives = 367/833 (44%), Gaps = 163/833 (19%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K++++VES KAK I KYLG Y V S GH+RDL +K + Sbjct: 295 AKSVLVVESVTKAKVIQKYLGDMYEVLPSYGHVRDLA---------------GRSKSVRP 339 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 D+ ++V + W + ++ L G + V A+++ LA+D DREGEAIAW Sbjct: 340 DDDFSMVWEVPAAAWTHLKSIRTALKGYDNAVW--------AENLILASDPDREGEAIAW 391 Query: 122 HLREVIG-----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 H++E++ G +RVVF+EIT++A+++A P +++D VNA ARR +D ++G Sbjct: 392 HIKEMLEQQDALGSKVTVARVVFHEITEDAVKKALISPRYIDMDLVNAYLARRSLDYLIG 451 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT-----PSG 231 + +SPLLW+K+ SAGRVQS A+ LV +RE EI+ F P+E+W VD T +G Sbjct: 452 FGISPLLWRKLPGCQSAGRVQSAALALVCDREAEIEQFDPQEYWTVDTDFKTQHSGPSNG 511 Query: 232 EALALQVTHQNDKPFRPV---NKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 L ++ H N K + ++E+ + +++ V + P P+ITS+ Sbjct: 512 LNLQSRIKHLNSKKLDQLSIRSQEEAHNIEKRIYSSQFEVTGIKRSKINKNPPMPYITSS 571 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTD---------------- 323 LQQ A+ +L F TM +AQ+LYE G ITY+RTD Sbjct: 572 LQQDAANKLHFSAGYTMKVAQKLYEGINLSSEEATGLITYIRTDGFHWYQSARGQCVFLC 631 Query: 324 -------------------------------------STNLSQDAVNMVRGYISDNFGKK 346 S +S A + + +G++ Sbjct: 632 SRVRGGIEEALACLACEQLSAAQATIIAAHDNRIVANSIFISDGAAEDILSLVKQRYGEE 691 Query: 347 YLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMT 404 Y E +Y K +N+QEAHEAIRP+ + + SL ++ D+ KLY LIW++ +ACQM Sbjct: 692 YASEGIRKYFKKVKNAQEAHEAIRPTSIRRLPSSLVGALDDDSLKLYTLIWKRTMACQME 751 Query: 405 PAKYDSTTLTVGA--GDFRLKARGRILRFDGWTKVMPALRKG-------------DEDRI 449 ++ D + +G GD + L F G+ V D Sbjct: 752 ASRTDMIQVDIGNSEGDMIFHSSASRLDFKGYQAVYDDTEASPSSYNSEVDAVHQDNFEA 811 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 L + D ++ V + +QHFTKPP+R+SE++L+K+LE+ GIGRPSTYASI+ +QDR Y Sbjct: 812 LSKLEVKDLVSPVNVHLSQHFTKPPSRYSESALIKKLEELGIGRPSTYASIMKVLQDRKY 871 Query: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 V +++R + E G +V+ L +F E+ + FTA ME LD V+ EWK +L F+ Sbjct: 872 VTIKSRVLHPEFRGRMVSAFLMHHFSEVADLSFTANMETELDNVSAGSTEWKGLLKDFWE 931 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 F + A + R + ++ + P +M G L Sbjct: 932 RFNKYCGDASRLDVRKVERKSLLISHKVQLPLKVERML--EEKFGSIL------------ 977 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRK--LHVCGNNP 687 ++ R CP C + + + C +P Sbjct: 978 ----------------------FSDLDNDSRICPSCSEGTLRFKVSRYGEGYFIGCDRHP 1015 Query: 688 TCDGYEI----------EEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 C E + + ++ LK G +G Y+ Sbjct: 1016 KCKYIARTLSDDDDETEASDETQRTFTPRLLGALPDSDEKVFLKQGPYGHYVQ 1068 >UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepID=TOP1_METJA Length = 761 Score = 517 bits (1332), Expect = e-145, Method: Composition-based stats. Identities = 204/857 (23%), Positives = 340/857 (39%), Gaps = 179/857 (20%) Query: 3 KALVIVESPAKAKTINKYLGS-------------------DYVVKSSVGHIRDLPTSGSA 43 AL+I E P+ AK I LG +V S+VGH+ L + Sbjct: 6 TALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKENK 65 Query: 44 AKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKE---KVVSELKQLA 100 K V GKE K + LK+L+ Sbjct: 66 EFGFYPVFDIKWVPA-------------------------SVDKGKEYVNKYIKALKKLS 100 Query: 101 EKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNID 160 + AD Y+ATD D EGE I +H + G + + R+ F+ +TK I +AF P E++ Sbjct: 101 KDADEFYIATDWDIEGELIGYHALKYCCGRE-KAKRMRFSSLTKKEIVRAFENPDEIDYG 159 Query: 161 RVNAQQARRFMDRVVGYMVSPLLWKKIA-----RGLSAGRVQSVAVRLVVEREREIKAFV 215 V+A ++R +D G +S L I + +S GRVQ A+ + ERE EIK F+ Sbjct: 160 LVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFI 219 Query: 216 PEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 P+ +W ++A L+ H+ +K + KE + ++ V+E + Sbjct: 220 PKPYWVIEALLKDN------LKAIHEKEKFWN--EKEAKNVYEKIKDEKSAKVVEIKKTK 271 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD----- 330 KP PF TLQ+ A + K+T +AQ+LYE I+Y RT S L +D Sbjct: 272 RKLKPLPPFDLGTLQREAYSYFKISPKETQEIAQKLYENALISYPRTSSQKLPKDRKYLE 331 Query: 331 -AVNMVRGY-ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ 388 +N+++ + + + ++ L E+ K+ AH AI D+ S K+ + Sbjct: 332 DILNIIKNHPVYGKWAERILKENLKPVEGKK-EDPAHPAIHIVDIPKEELSEKE-----K 385 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR 448 ++Y LI R+ +A A+ + + + + K G +GW ++ + + + Sbjct: 386 EIYDLIARRTLAAFWDNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIYYFPKFDEIE- 444 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508 LP + K D + + ++T + T+PP R++ AS++KELEKRG+G +T A II + RG Sbjct: 445 -LPPLKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKRGLGTKATRAEIIDKLIKRG 503 Query: 509 YVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 YV +++ +G V + L+ E+++ T +E L+++ + + VLD Sbjct: 504 YV-IDDGSLKVTDLGISVIETLKRFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVLDEAE 562 Query: 569 SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKE 628 + L + + G++L Sbjct: 563 KRLRKIL----------------------------EEFKKKEEDIGIYL----------- 583 Query: 629 RCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPT 688 ++ DA + +CPKCG + R C N P Sbjct: 584 -----------------IKNLDATNKKAKIVGKCPKCGGDLILIRHKKGR-FVGCSNYPE 625 Query: 689 CDGYEIEEGEFRIK-----------------------GYDGPIVE---------CEKCGS 716 CD + RIK + P+ + C KCG+ Sbjct: 626 CDVKYSLPDKGRIKIPNKVCDACKSPILKIGDREICINPECPLKQVEVKEEDRICPKCGA 685 Query: 717 EMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDG 775 ++ LK G +G + C+N +CK T I + V C K V+R+G Sbjct: 686 KLILKKGVYGAFYGCSNYPKCKYTEPINKKEVVG------------KCPKCGGDLVVREG 733 Query: 776 AAGVFLAANTFPKSRET 792 G F+ + +PK R T Sbjct: 734 KFGKFVGCSNYPKCRYT 750 >UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J356_DESRM Length = 799 Score = 515 bits (1326), Expect = e-144, Method: Composition-based stats. Identities = 186/797 (23%), Positives = 305/797 (38%), Gaps = 111/797 (13%) Query: 3 KALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADST 51 K LVI E P+ K I LG Y+V + GH+ +L Sbjct: 2 KTLVITEKPSVGKDIASVLGRFESKDGYLENEKYIVSWAFGHLVELADPSVYDPVFKKWD 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADH--IYLA 109 P + E+ K + LK+L A+ + Sbjct: 62 LATLPIIPDSFKLV------------------EIAGSSAKQLRTLKKLLNSAEVSQVVNG 103 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQA 167 D REGE+I + G R+ +E T A++ AF E + A +A Sbjct: 104 CDAGREGESIFRRIYHFCGCR-KPIKRLWLSETTPAAVKAAFKALREGQEYNNLAAAAEA 162 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D +VG + + LS GRVQ+ + L+V REREI FVP +WEV + Sbjct: 163 RGQADWLVGLNGTRAFTVRHGTVLSVGRVQTPTLNLIVSREREINNFVPVPYWEVWGTFQ 222 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLL-EKARYSVLEREDKPTTSKPGAPFIT 286 T +G + D R N+E + L +A+ V+ E K P F Sbjct: 223 TDNGMYKGKWFREKED---RLPNREAALNLTTKLSSEAKGQVISLEQKEAKELPSFLFNL 279 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYI-----S 340 + LQ+ + R GF ++ + +AQ LYE +TY RTDS +LS ++ + + + Sbjct: 280 NDLQKEGNRRYGFTAQQVLDIAQSLYEKHKLLTYPRTDSRHLSNAMISTLPERLATLKNA 339 Query: 341 DNFGKKY---LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 + + LP +Y + H AI P+ V+ L D +K+Y L+ R+ Sbjct: 340 PKYAELIPDTLPGLSKRYV-DDGKITDHHAIIPTAVDPSKAQLSD---QEKKIYDLVVRR 395 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD---------EDR 448 F++ A+Y T + K+RGR+ GW V + ED+ Sbjct: 396 FLSIFYPEARYAVTEVFTETAGELFKSRGRVELAAGWKMVWRGSDQETAEEGNGDDPEDQ 455 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR-----------------GI 491 LP + +G ++ + ++ + TKPP RF+EA+++ +E GI Sbjct: 456 ALPPLTQGKSVDVSKVEILEKQTKPPKRFTEATILAAMESAGKFVEDKEMAEVLKQTGGI 515 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G P+T A+II + GYV + + G+I+ D + + +L + + TA E+ L Sbjct: 516 GTPATRAAIIERLIKVGYVARDKKSLVPTAKGQILIDLVPK---QLKSVELTASWEDGLR 572 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 +V + + + + + A G+ + T CP CGR + Sbjct: 573 RVEEGQQNAALWIQDIQAYTRELVVLARNQEVSQGVGTARD--TLGKCPVCGRDVV---- 626 Query: 612 STGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED--AETNALRAKRRCPKCGTAM 669 T GCSGY KE CK I ++ ++ + E + K K G Sbjct: 627 ETAKSYGCSGY----KEGCKFAIWKEINSKKISAKQAETLLTKGKTGLIKGFKSKAGKTF 682 Query: 670 DSYLI---DPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG 726 D+ L+ D K G+ + + + +C CG ++ +G Sbjct: 683 DALLVLGEDGKITF----------GFANAVNDQPGSTGNTALGKCPLCGKDVVENSRSYG 732 Query: 727 KYMACTNEE--CKNTRK 741 C+ + CK Sbjct: 733 ----CSGYKDGCKFVIW 745 >UniRef50_O66893 DNA topoisomerase 1 n=2 Tax=Aquificaceae RepID=TOP1_AQUAE Length = 540 Score = 514 bits (1324), Expect = e-144, Method: Composition-based stats. Identities = 217/574 (37%), Positives = 319/574 (55%), Gaps = 52/574 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L IVESP KAKTI K+LG ++VK+++GH++DLP Sbjct: 3 LFIVESPTKAKTIQKFLGKGFLVKATLGHVKDLPE------------------------- 37 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +GVD +A Y GK+K+V +LK+L+ ++ +YL TD DREGEAIA+ L+ Sbjct: 38 ----KELGVD-LRTLKAKYVYKRGKKKLVEQLKKLSRRSSIVYLGTDPDREGEAIAYFLK 92 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 + + + R VF EIT AIR++ G++N++ V AQ ARR +DR++GY++SP+LW Sbjct: 93 KDLEKVNKNIKRAVFYEITPEAIRESIRNAGDVNMNLVYAQFARRILDRLIGYLISPILW 152 Query: 185 KKIAR-GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 K+ LSAGRVQS A+RL+VEREREI+ F ++++ V A S E A+ Sbjct: 153 KEFKNYKLSAGRVQSPALRLIVEREREIQNFKVKKYYYVKALLRKGSEEFWAIY------ 206 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 +R N + LEK +SV + E K P PFITS LQ A+ + GF ++ Sbjct: 207 -DYRYENPSDAKIIAKKLEKGYFSVYKVEKKKEKVSPPKPFITSDLQSEANAKFGFSSER 265 Query: 304 TMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQE 363 T +AQ LYE GYITY RTDS +++ YI +GK+Y+ ++ K +Q Sbjct: 266 TQKLAQELYEKGYITYPRTDSYRMNEKKAKEFMNYIEKKYGKEYVGRL-RRFREKATAQG 324 Query: 364 AHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA------ 417 AHE IRP+ + +++ + LY LI+R+ +A M + +TV A Sbjct: 325 AHECIRPTSLREEIPEREEL----RLLYDLIFRRTIASLMKEMLLEREKVTVEAITPELK 380 Query: 418 GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARF 477 L A+G + FDGW++V P+ + LP + +GD L LV+ T + T+PP R+ Sbjct: 381 HPVYLVAKGLKIVFDGWSRVYPS---EITEEKLPELYEGDLLDLVKTTLEERKTQPPPRY 437 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFREL 537 +E +L+K LEK GIGRPSTYA+I+ T+++RGYV V+ + ++ V + L E F L Sbjct: 438 TEGTLIKTLEKLGIGRPSTYATIVKTLKERGYVEVKKKALVPTEIAFQVVEFLMERFPTL 497 Query: 538 MNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 M+Y FTAQME LD V + WK+V+ F Sbjct: 498 MDYKFTAQMEEKLDLVEEGKLNWKSVVYEFMEKI 531 >UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LTI8_DESBD Length = 620 Score = 513 bits (1322), Expect = e-144, Method: Composition-based stats. Identities = 153/621 (24%), Positives = 257/621 (41%), Gaps = 66/621 (10%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M + L+I E P+ A+ + LG ++V +VGH+ ++ Sbjct: 1 MPRTLIIAEKPSVARELAGVLGVKGRGDGFLQGPGHIVTWAVGHLVNIAEPAEQNPA--- 57 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIY 107 + M P +LP K ++ + D + Sbjct: 58 ---------------WSGRWSMRQLPMLPSRFTLGILPSTAKQYEIIRNFLLDDDIDSVV 102 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQ 165 ATD REGE I + ++ G R+ N++T+ +++AF GE + +A Sbjct: 103 NATDAGREGELIFRRIY-LLAGSTKPIKRLWANDMTEKGLQKAFAGMVSGEEKRNLGHAA 161 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D +VG S L + ++ GRVQ+ ++L+VER REI+ F+P ++W V+ Sbjct: 162 FARAEADWLVGMNFSRLFTLRAGSLITVGRVQTPVLKLLVERRREIENFLPRDYWTVEGE 221 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 A + K + E+ Q V +VLE E K KP F Sbjct: 222 FAHEGETFKATWFAAPDFKDSKIWQVEEGQTVVQACAGKDGAVLEMEKKKGRQKPPLLFD 281 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRGY------ 338 + LQ+ A++RLGF ++T+ +AQ LYE ITY RTDS L+++ Sbjct: 282 LTNLQKEANSRLGFSAQQTLSIAQDLYEKRKLITYPRTDSRYLTKELFAECLENMRAVYA 341 Query: 339 ----ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 IS + + H AI P+ + +L + +Y++I Sbjct: 342 HFPEISQSAAANIKDAKKKFECVNDKKVSDHHAIIPTTLRANPATLGK---EEWAIYEMI 398 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVN 454 R+F A M A + S+TL +G R +A G+I + GW + P + ED LP + Sbjct: 399 CRRFAAAFMDDATFASSTLWIGVEGHRYRATGKIFQDKGWLEAEPW--RASEDNPLPNLR 456 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRPSTYA 498 KG A+T L H TKPPA F++A+L+ +E +RG+G P+T A Sbjct: 457 KGAAVTAQSLDLVAHKTKPPAHFTDATLLAAMETAGKLIDDEELRDAMKERGLGTPATRA 516 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 II T+ R Y+ + +R A +G D + ++ + + T + E L ++ Sbjct: 517 QIIETLLARKYIGKDGKRLVATDLGCWAVDVVCSMIPQVASPELTGEWEKRLKEMEQGGY 576 Query: 559 EWKAVLDHFFSDFTQQLDKAE 579 + + + + + + Sbjct: 577 AYGVFMHQVREMVSSGVSRVK 597 >UniRef50_A4BJY7 Topoisomerase I n=1 Tax=Reinekea blandensis MED297 RepID=A4BJY7_9GAMM Length = 713 Score = 513 bits (1320), Expect = e-143, Method: Composition-based stats. Identities = 238/727 (32%), Positives = 335/727 (46%), Gaps = 68/727 (9%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+IVESP K K I +YLG+ ++VK+SVGHIRDLP Sbjct: 2 KLMIVESPNKCKKIAEYLGAGWMVKASVGHIRDLPQ------------------------ 37 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +GVD + + Y + GK KVV +L+ A KAD ++LATD DREGEAIA+H+ Sbjct: 38 -----KDLGVDVENRFRPAYVISEGKHKVVKDLQAAAAKADEVWLATDPDREGEAIAYHI 92 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 R V+G D Y RV FNEI K +I++A P +LN+ V AQ+ RR +DR+VGY VSP L Sbjct: 93 RTVLGLKD-NYKRVTFNEINKGSIQKALASPRKLNMQMVAAQETRRILDRLVGYTVSPAL 151 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 + + G+SAGRVQS AVRLVV+REREI+ F P++ + A T +G + L + Sbjct: 152 QAQSSAGMSAGRVQSPAVRLVVDREREIQGFTPQDHYT--AVITLDNGLEMKLDTKPLQN 209 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 + A + L + + +P P F TS LQQ AST+LG + Sbjct: 210 AEGLVTDPAIIDAILHPLSD--VIITKAATEPKQVNPKPVFTTSELQQVASTKLGLSPDQ 267 Query: 304 TMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQE 363 TM AQ L+EAG ITY RTD NLS D M+ Y+ G PE A N+QE Sbjct: 268 TMKQAQSLFEAGRITYHRTDDPNLSDDGWAMIAAYLESQ-GIPVSPERRKWKAKDANAQE 326 Query: 364 AHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG----- 418 AHE IRP+ + D +LY+LI+ + +A ST + A Sbjct: 327 AHEGIRPTSMTDEPGQ-----GDTDQLYRLIYERAMAAVTVNGVDISTQVIAKATLDLDV 381 Query: 419 DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF-TKPPARF 477 KA G+++ GW ++M +D L V D + V + T PPAR+ Sbjct: 382 PVEFKASGKVVETMGWRQLMTIEVAESKDTQLKCVPDVDQVCAVAAKSRKDQVTTPPARY 441 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRLEENFRE 536 +EASLVKELEKRGIGRPSTYA+I + R Y+ V + R+ +G V D L E Sbjct: 442 TEASLVKELEKRGIGRPSTYATIFVNVFRRQYLEVGKGRQITPTPLGVAVVDALMSM--E 499 Query: 537 LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTS 596 M+YD+TA +E+ LDQ+ + V+ + L K + T Sbjct: 500 FMDYDYTANLESQLDQMVEGRLKLLDVVGPAYQQIVDDLPKVSVNQSSISQFEQ---GTQ 556 Query: 597 IDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAET-NA 655 C CG + PK+ ++ ++ + A Sbjct: 557 EACIQCGHPIKRLPKK-----------SNPKQFFWVHVDEAHAEGCEKFIDDMRGKPYMA 605 Query: 656 LRAKRRCPKCGTAMDS-YLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC 714 +C C ++ Y R V ++ C ++ + P C C Sbjct: 606 DLQSHQCKLCNGDLERAYSKAKNRHFWVHKDDSDCAKRTYQDRSGKPVLDALP---CPGC 662 Query: 715 GSEMHLK 721 G + + Sbjct: 663 GFALVRR 669 >UniRef50_Q18KP8 DNA topoisomerase n=6 Tax=Halobacteriaceae RepID=Q18KP8_HALWD Length = 857 Score = 512 bits (1318), Expect = e-143, Method: Composition-based stats. Identities = 191/781 (24%), Positives = 335/781 (42%), Gaps = 79/781 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+I E A+ I L D D + K + D Sbjct: 7 LIITEKDNAARRIADILSGDSATA-------DREQGVNVYKWGGKRCIGLSGHVVAVDFP 59 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 + V+P +A E P K+ +V+ LK+LA +A + +ATD DREGE I Sbjct: 60 QEYSDWRDVEPVELIDAPIEKNPTKQNIVTTLKKLARRARRVIIATDYDREGELIGKEAY 119 Query: 125 EVIGGDD--ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 E++ + RV F+ IT+ ++ AF P +L+ + A +AR+ +D V G ++ Sbjct: 120 ELVRRVNESTPIDRVRFSSITEESVTTAFENPDDLDFNLAAAGEARQVIDLVWGAALTRY 179 Query: 183 LWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWE-----------VDASTT 227 L + +S GRVQ ++L+V+REREI+AF PE++WE ++ ST Sbjct: 180 LSLSAGQLGSDFISVGRVQGPTLKLIVDREREIEAFDPEDYWELFVDLTQADKPIEVSTD 239 Query: 228 TPSGEALALQVTHQND--KPFRPVNKEQTQAAVSLLEKARYS-VLEREDKPTTSKPGAPF 284 + E A H +D + R + + LE A + V + + T +P APF Sbjct: 240 DTAAEFEAQYFYHADDGTEAERITEESTAKTVFETLESASIAHVDSVKRRTRTDEPPAPF 299 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGYISDN 342 T+ AA + +G+ ++ M +A+ LY AGYITY RTD+T + ++ + + Sbjct: 300 NTTQFISAAGS-IGYAAQRAMDIAEDLYTAGYITYPRTDNTVYPDELDPRELIEALTNGS 358 Query: 343 ----FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 + L + + + H I P+D +++ D ++Y+LI R F Sbjct: 359 RFGSDARDVLDQETLSPTTGDEETTDHPPIHPTDELPKP---SELDDDKWEVYELIVRHF 415 Query: 399 VACQMTPAKYDSTTLTVGAGD-FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 +A PA ++ + D + +K+ GR L G+ V P + ++P + G+ Sbjct: 416 LATVSNPATWEHLRIVAIVDDTYSIKSNGRRLLNPGYHAVYPYSNAT--ESLIPDIEDGE 473 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L L++ T+PP R+ ++ L++ +E GIG S+ ++I + +RGY+ + R Sbjct: 474 TLRLIDSRIEAKQTQPPRRYGQSRLIETMESMGIGTKSSRHNVIQKLYNRGYIESDPPR- 532 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL---DHFFSDFTQQ 574 ++ V + EE +++ + TAQ+E + +A E ++V +D ++ Sbjct: 533 -PTQLARAVVEAAEEFAELIVSEEMTAQLETDMQAIAEGEETLESVTSASRSILTDVFKK 591 Query: 575 LDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV-FLGCSGYALPPKERCKTT 633 L + + + R + T CP C + R + G F+GC Y C+ T Sbjct: 592 LMNTDAEIGDHLQRSMKADKTIGPCPQCEGDLITRKSQAGSHFIGCDSYP-----DCEYT 646 Query: 634 INLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE 693 + L P ++LE C L + +H C P C+ Sbjct: 647 LPL-PSTGKPHILET------------VCDVHNLQQIKMLAGKRSFVHGC---PLCEAEA 690 Query: 694 IEEGEFRIKGYDGPIVECEKCG----SEMHLKMGRFG-KYMACTN-EECKNTRKILRNGE 747 +E R+ G C +C E+ +K R G + + CT +C+ + + R GE Sbjct: 691 ADEQADRVIG------TCPECNAHADGELAIKRLRSGSRLVGCTRYPDCEYSLPLPRQGE 744 Query: 748 V 748 + Sbjct: 745 I 745 Score = 53.6 bits (127), Expect = 3e-05, Method: Composition-based stats. Identities = 23/155 (14%), Positives = 43/155 (27%), Gaps = 29/155 (18%) Query: 654 NALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEK 713 A + CP+C + + CD Y E + P + Sbjct: 608 KADKTIGPCPQCEGDLITRKSQAGSHFIG------CDSYPDCEYTLPLPSTGKPHILETV 661 Query: 714 CG----SEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA- 768 C ++ + G+ C C E A + D V C + +A Sbjct: 662 CDVHNLQQIKMLAGKRSFVHGC--PLC--------EAEAADEQADRVIGT---CPECNAH 708 Query: 769 ---YFVLRDGAAG-VFLAANTFPKSRETRAPLVEE 799 ++ +G + +P + PL + Sbjct: 709 ADGELAIKRLRSGSRLVGCTRYPDCEYSL-PLPRQ 742 >UniRef50_Q1AY08 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AY08_RUBXD Length = 701 Score = 511 bits (1316), Expect = e-143, Method: Composition-based stats. Identities = 157/680 (23%), Positives = 263/680 (38%), Gaps = 85/680 (12%) Query: 5 LVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 L++ E P+ + I LG S +VV ++GH+ +L + + + Sbjct: 3 LIVAEKPSVGRDIAGALGRHRREGDALVGSGWVVTWALGHLAELAPPDAYGAEYKRWSLQ 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK--ADHIYLATD 111 P++ V P + +++ + A D Sbjct: 63 NLPILPER-------------------FRVRVNPRTRERFEAVRRWMRDPSVTEVVNACD 103 Query: 112 LDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARR 169 REGE I +L + + + R+ + +T AIR+ F + +A ++R Sbjct: 104 AGREGELIFAYLYQ-LSRCEKPVRRLWVSSLTPEAIREGFGSLRDGPSMKPLEDAARSRA 162 Query: 170 FMDRVVGYMVSPLLWKKIAR---GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D +VG + + +R LS GRVQ+ +RL+VEREREI+ F PE F+ V A Sbjct: 163 EADWIVGMNATRAYSVRFSRPGDVLSVGRVQTPTLRLLVEREREIEDFRPERFFTVHARF 222 Query: 227 TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFIT 286 L +K R +E + + V + E + T+ +P + Sbjct: 223 ARDGKTYDGLWF---REKESRLKEREAAEQIAEKVRGGTGVVKKAERRRTSERPPLLYDL 279 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGYISDN--- 342 + LQ+ A+ R GF ++T+ AQ LYE ITY RT S LS D V ++ + Sbjct: 280 TELQRNANARYGFTAERTLRAAQALYEERKLITYPRTSSRYLSGDMVGTLKRRVEAAGGL 339 Query: 343 -----FGKKYLPESP---NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 F + L + ++ H AI P+D + D K+Y L+ Sbjct: 340 PELAPFAGRLLAAGSLPVGRRVVDDSKVTDHHAIVPTDRKPSG----GLPPDEAKVYDLV 395 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP---ALRKGDEDRILP 451 R+F+A A++++TT+ A ++GR++ GW ++ P RK E LP Sbjct: 396 ARRFLAVFFPAARFENTTVVTEARGETFLSKGRVVLEAGWRELYPDGVGGRKEKEPPALP 455 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRPS 495 V G + ++ + TKPP R+SE++L+ +E G+G P+ Sbjct: 456 PVEAGQEWRVAKVGVKEGETKPPPRYSESALLGAMETAGKLVEDEELRQQMKDSGLGTPA 515 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 T A+II + GYV E + G + L + L + + TA+ E L ++ Sbjct: 516 TRAAIIERLIKVGYVEREKKALVPTAKGRALISLLAD--SPLSSPEMTARWERRLARIER 573 Query: 556 HEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV 615 E + ++ + E P CP CG + T Sbjct: 574 GEERRPDFMSDISGFAASVVEGVRRMEGEKIAAPGGGGEALGACPKCGSPVV----ETKK 629 Query: 616 FLGCSGYALPPKERCKTTIN 635 GCS + K C I Sbjct: 630 AYGCSAW---RKTGCDFAIW 646 >UniRef50_Q9JN65 DNA topoisomerase 1 n=2 Tax=Mycoplasma gallisepticum RepID=TOP1_MYCGA Length = 719 Score = 510 bits (1313), Expect = e-142, Method: Composition-based stats. Identities = 225/745 (30%), Positives = 344/745 (46%), Gaps = 68/745 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K LVI ESP K KTI KYL DY + ++VGHIRDLP PK Sbjct: 6 SKILVI-ESPNKVKTIKKYLTDDYEIVATVGHIRDLPK--------YTLGFNTEDFVPKW 56 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + GV + + + K++++ EL A+KAD IYLATD DREGEAI+W Sbjct: 57 EIIQEKKPAKGVSATKKAKTVKKAVKNKKEIIDELVDKAKKADEIYLATDPDREGEAISW 116 Query: 122 HLREVIGGDDARY---SRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 H+ +V+ R++FNEI++ A++ A P E+ D V++Q RR +DR++G+ Sbjct: 117 HVYDVLKEKGVNVNKCKRIIFNEISEKAVKNAIANPREIQKDWVSSQITRRRLDRLIGFK 176 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +S L+ KI SAGRVQS+A++ + ERE I FVP +W +D + L Sbjct: 177 LSSLMKSKINAD-SAGRVQSIALKFITEREELINKFVPRFWWTLDVILKDGTELMLRKID 235 Query: 239 THQNDKP----------FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 DK KE + L K +S P + TST Sbjct: 236 EKLKDKLGFKELEEVSGIDFNTKEDAELVKQHLSDKYRVYAIDTPKLKSSYPKEVYKTST 295 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYIS 340 LQQ A +L + K +AQ LYE I+Y RTDST LS + V +++ Sbjct: 296 LQQDAINKLKWRSMKITSVAQELYEGVTIDDEQIALISYPRTDSTRLSPEYGKTVLDFVA 355 Query: 341 DNFGKKYL-------PESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQ 392 +GK Y+ E+ K Q+AHEAI P D+++ +S+K + +D LY+ Sbjct: 356 KTYGKDYVATQSQLNGETKANKKQKAKVQDAHEAIHPIDISITPDSVKNKISSDQYSLYK 415 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILP- 451 LIW + VA M A Y+ + + + A L+FDG+ K+ D R L Sbjct: 416 LIWTRTVAHYMAAAVYELVNIRFINNNNKFYAVNNTLKFDGYKKIYTHYDDKDHLRKLDL 475 Query: 452 -AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 ++ +H TKPPARF++A+L++ LE GIGRPSTY++I+ + R Y Sbjct: 476 NHFAIDKEFEAKDVLLNEHQTKPPARFTQATLIEALETEGIGRPSTYSTILDIVLKRNYA 535 Query: 511 RVENRRFY-AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 + N R+Y +G+ + L++NF ++N +FT ME +LD++A + L F++ Sbjct: 536 ELVNGRYYKTTDLGQKLAFELDKNFPTIINKEFTKNMETTLDEIAQGTVNDVSYLQAFWN 595 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 DF++ L++A+ + + + +CP C ++ R G F+GCS + + Sbjct: 596 DFSEVLNEAKTNIVKKVEY-----IEGKNCPNCSSQLVRREGRYGPFVGCSNFP-----K 645 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR-----KLHVCG 684 CK + + + EG +C C + + K C Sbjct: 646 CKFIEKSEQKAKEIVYEEG-----------VKCELCHAKLIRRVAKKKGRNKDNTFLGCS 694 Query: 685 NNPTCDGYEIEEGEFRIKGYDGPIV 709 N P C + E E D I+ Sbjct: 695 NFPKCKYTKSLEPEKDETIRDSTII 719 Score = 83.6 bits (205), Expect = 3e-14, Method: Composition-based stats. Identities = 25/103 (24%), Positives = 43/103 (41%), Gaps = 13/103 (12%) Query: 710 ECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA 768 C C S++ + GR+G ++ C+N +CK K + + + V + CE A Sbjct: 619 NCPNCSSQLVRREGRYGPFVGCSNFPKCKFIEKSEQKAK------EIVYEEGVKCELCHA 672 Query: 769 YFVLRDGAAG------VFLAANTFPKSRETRAPLVEELYRFRD 805 + R FL + FPK + T++ E+ RD Sbjct: 673 KLIRRVAKKKGRNKDNTFLGCSNFPKCKYTKSLEPEKDETIRD 715 Score = 52.8 bits (125), Expect = 5e-05, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 15/35 (42%) Query: 758 LPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRET 792 + C + V R+G G F+ + FPK + Sbjct: 615 IEGKNCPNCSSQLVRREGRYGPFVGCSNFPKCKFI 649 >UniRef50_B1X1Z5 DNA topoisomerase n=3 Tax=Chroococcales RepID=B1X1Z5_CYAA5 Length = 719 Score = 508 bits (1308), Expect = e-142, Method: Composition-based stats. Identities = 225/723 (31%), Positives = 349/723 (48%), Gaps = 73/723 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K ++++E+P K K + K+LG+D+ V ++ GHIR+ SG+ + PK Sbjct: 16 MAKNVLVIEAPGKRKKLEKFLGADWTVIATGGHIREFDKSGNH--------NLGFELTPK 67 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK--ADHIYLATDLDREGEA 118 V R +KV+ +L+ A++ ++ I++ATD DREGE Sbjct: 68 GTVIPKFVPR---------------SERSKKVIRQLQMTAKRTNSERIFIATDPDREGEC 112 Query: 119 IAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 I WH +V+G + R+V++EI++ A+R+A P L+ + V + R +D+++GY Sbjct: 113 IGWHAAQVMGIKNP--QRIVYSEISEKAVRRAIANPRFLDTNLVASALGRSTLDKLIGYT 170 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 SPLLW + S GRVQ+ + L+ ERE I+ F PE ++ V + A + Sbjct: 171 GSPLLWDYVEGAKSMGRVQTPVLTLICEREETIQNFKPETYYSVWSLYKEGLKAFYAGES 230 Query: 239 THQND-----------------KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 ++ + R ++ + V++ ++V+ E K + P Sbjct: 231 NDNSEDSEEERDDSQTPKETQKESLRVTSEAEANRLVAIARNNSHNVVSLETKKSKKSPP 290 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 APF TS LQQAA RL F +TM +AQ+LYEAG ITY RTDST +S D ++R Y+ Sbjct: 291 APFTTSNLQQAAGARLKFSPDQTMKLAQKLYEAGVITYHRTDSTVISGDFCKVIRQYLKA 350 Query: 342 NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVA 400 N + LP+S ++ +N+QEAHEAIRP D+ + ++ A KLYQLIW + VA Sbjct: 351 N-DPENLPKSVIKHRQSKNAQEAHEAIRPVDLAKTETDIASELGDAAGKLYQLIWFRTVA 409 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALT 460 Q PA+ D TT+T + KA+G+++ F G+ + L E LP+V +T Sbjct: 410 SQCKPAELDKTTITTQSDTVFWKAKGQVVTFAGYLRYWRDLGADSE---LPSVENHQVVT 466 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 L + + TKPP+RF+EA +VK EK+GIGRPST++ I T++DR YV VE R Sbjct: 467 LEDAQAEKKQTKPPSRFTEAQMVKVREKKGIGRPSTFSPTIQTLKDRNYVAVEKRMLKPT 526 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF----FSDFTQQLD 576 ++G V + E+ EL +FTAQME+ LD +A + +W+ + F + ++ Sbjct: 527 QVGLKVYHFVREHLTELGTVEFTAQMESHLDAIAKGDEKWQPYVCQFHFDHWQPTLIKIA 586 Query: 577 KAEKDPEEGGMRPNQMVLTS--IDCPTCGRKMGIRTASTGV-----FLGCSGYALPPKER 629 + P N L CP C M + + FL C E Sbjct: 587 QTLGKPAVKSFNGNGKSLEKSRTKCPKCNVAMSKVPSKSKKLHRPYFLKC--------ED 638 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA--MDSYLIDPKRKLHVCGNNP 687 C+T + E + E ++ K CPKC + Y K Sbjct: 639 CETVMFYNKERKQ---WESPGTKSPTQETKASCPKCQKPLHLREYRSKKDGKQKKLLKCL 695 Query: 688 TCD 690 CD Sbjct: 696 DCD 698 >UniRef50_B9LRP1 DNA topoisomerase n=4 Tax=Halobacteriaceae RepID=B9LRP1_HALLT Length = 864 Score = 507 bits (1305), Expect = e-142, Method: Composition-based stats. Identities = 209/844 (24%), Positives = 347/844 (41%), Gaps = 112/844 (13%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+I E A+ I L + + + K + D Sbjct: 7 LIITEKDNAARRIADILSGESATA-------ERENDVNVYKWGGKRCIGLSGHVVGVDFP 59 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 + V+P +A P +E +V+ L++LA A + +ATD DREGE I Sbjct: 60 AEYNDWRDVEPVELIDAPITKEPTQEGIVAALRKLARNASRVVIATDYDREGELIGKEAY 119 Query: 125 EVIG--GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 E++ +DA RV F+ IT N + +AF P EL+ D A +AR+ +D G ++ Sbjct: 120 ELVREVNEDAPIDRVRFSSITDNEVNEAFANPDELDFDLAAAGEARQVIDLTWGAALTRF 179 Query: 183 LWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 L + +S GRVQ ++L+V+REREIKAF PE +WE+ + T G+ + Sbjct: 180 LSLSARQLGEDFISVGRVQGPTLKLIVDREREIKAFDPEAYWELYGNLTKSGGDPFEARY 239 Query: 239 THQND---KPFRPVNKEQTQAAVSLLEKARYSVL-EREDKPTTSKPGAPFITSTLQQAAS 294 + ND + R N + + + A +V+ + + T P PF T+ +AA Sbjct: 240 FYLNDEGNEAERVWNGDVAEVLTEAFDAADEAVVDDVRRRTRTDDPPTPFNTTAFIRAAG 299 Query: 295 TRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGY-ISDNFGKK---YL 348 + LG ++ M +A+ LY AGY+TY RTD+T +D ++ ++ FGK L Sbjct: 300 S-LGHSAQRAMSLAEDLYTAGYVTYPRTDNTVYPEDLDPRELIEELSVASTFGKDAKSLL 358 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKY 408 + + + H I P+ S D+ D ++Y+LI R+F+A PA + Sbjct: 359 EQEEIEPTEGDEETTDHPPIHPTG---ELPSASDLSEDEWEVYELIVRRFLATCAEPATW 415 Query: 409 DSTTLTVGAGDF--------------------------------RLKARGRILRFDGWTK 436 + + A D RLKA G+ L G+ Sbjct: 416 ERLRVVALANDEATAIAERADGLAALRNPEEASGPGDLVADGGLRLKANGKRLLEAGYHD 475 Query: 437 VMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPST 496 V P + ++RI+P V G+ L L + T+PP R+ ++ L++E+EKRG+G +T Sbjct: 476 VYPY--RSSDERIVPDVEVGETLALTDRRTDAKETQPPRRYGQSRLIEEMEKRGVGTKAT 533 Query: 497 YASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 + + DR Y+ + R ++ E V + EE +++ + TAQ+E + +A Sbjct: 534 RHRTLEKLYDRNYIESDPPR--PTRLAEAVVEAAEEFAEHVVSEEMTAQLERDMQAIAAG 591 Query: 557 EAEWKAVLDHFFSDFTQQLDKAEKDPEEGG---MRPNQMVLTSIDCPTCGRKMGIRTAST 613 E + V + + D + E G + + T CP CG + +R + Sbjct: 592 EKGYDEVTEASRELLNRVFDDLTESREAVGDHLQKSLKADKTLGPCPECGSDLLVRKSRQ 651 Query: 614 G-VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSY 672 G F+GC GY C+ T+ L + L + E C + Sbjct: 652 GSYFVGCDGYP-----DCEYTLPLPSSGKPLLLDET-------------CEEHELRHVKM 693 Query: 673 LIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC----GSEMHLKMGRFG-K 727 L K +H C P C E +E E + G C +C G E+ +K R G + Sbjct: 694 LAGRKTFVHGC---PQCKADEADEQEDEVIG------ACPECGEEHGGELAIKRLRSGSR 744 Query: 728 YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVF-LAANT 785 + CT +C + + R GE + + + CE+ + + L Sbjct: 745 LVGCTRYPDCDYSLPLPRRGE--------IEVTDEICEEHGLPHLRVHSGDEPWELGC-- 794 Query: 786 FPKS 789 P Sbjct: 795 -PIC 797 Score = 47.0 bits (110), Expect = 0.003, Method: Composition-based stats. Identities = 7/32 (21%), Positives = 14/32 (43%), Gaps = 1/32 (3%) Query: 762 PCEKSDAYFVLRDGAAGV-FLAANTFPKSRET 792 PC + + ++R G F+ + +P T Sbjct: 636 PCPECGSDLLVRKSRQGSYFVGCDGYPDCEYT 667 >UniRef50_Q9PHK2 DNA topoisomerase I, plasmid n=3 Tax=Gammaproteobacteria RepID=TOP1P_XYLFA Length = 660 Score = 507 bits (1305), Expect = e-141, Method: Composition-based stats. Identities = 223/715 (31%), Positives = 335/715 (46%), Gaps = 80/715 (11%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+I+ESP K + ++ LG + + +SVGH+RDLP Sbjct: 2 KLMIIESPGKIEKLSTILGDGWKIAASVGHVRDLPQKEMGVAAP---------------- 45 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +++ YE+ E VV++LK L ++AD +YLATD DREGEAI+WHL Sbjct: 46 --------------DFKPSYELTERGEGVVAKLKNLLKQADSVYLATDPDREGEAISWHL 91 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 ++ + + RV FNEIT NA++ + P +++ RV AQ+ARR +DR+VGYMVSP L Sbjct: 92 QQCLKLSNP--LRVTFNEITANAVKASLVAPRTIDVKRVAAQEARRVLDRLVGYMVSPEL 149 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP--SGEALALQVTHQ 241 + + LSAGRVQS AVRLVVEREREIKAF + SGE A +T Sbjct: 150 SRLTGKRLSAGRVQSPAVRLVVEREREIKAFKVTNHFGAMLFFADAKTSGEWSAEWLTKP 209 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 A ++ + V ++ P PF TST+QQAAS LG Sbjct: 210 KFVAEDNPYFMDRDFAAAVAQVKAVVVKSFDESEAKRSPPPPFTTSTMQQAASVTLGVDP 269 Query: 302 KKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENS 361 K M AQ+LYE G+ITY RTD+ N+S +++ + Y + E P ++ + + Sbjct: 270 KAAMDAAQKLYEQGHITYHRTDNPNVSDESLGDI--YAVSVKLGLDIAEKPRKFKAPAGA 327 Query: 362 QEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG--- 418 Q H A+ P+ V +D + LY+LI + +ACQ+ A+Y T+ + A Sbjct: 328 QVGHPAVTPTHWEVEEA---GETSDQKALYKLIRLRAIACQLADARYAVRTVRLEAAQPV 384 Query: 419 ---DFRLKARGRILRFDGWTKVMPALRKGDED-------RILPAVNKGDALTLVELTPAQ 468 + +ARGR L + GW K++ + +ED +P G+ L + + Sbjct: 385 GGKNVEFEARGRTLIYQGWLKLIAGDQTEEEDGNEKESSNPIPVCAPGECLDVARGKLLE 444 Query: 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528 TKPP+ +++A+LVK+LE GIGRP+TYA+I+ I RGYV+ E + + + GE++ D Sbjct: 445 KKTKPPSHYTQATLVKKLESEGIGRPATYAAIMDNIVSRGYVKTEKKYLFPTETGELIVD 504 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 L F E ++ FT ++E SLD++A E+ +KAV+ +L + Sbjct: 505 SLVGKF-EFLDLGFTREIEESLDRIAQGESGYKAVIAKVHDQLNMELSTLQV-------- 555 Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 C CG+ + G F GCSGY C T P+ + Sbjct: 556 ---SATPKHPCQECGKPLRRIPGKNGHFWGCSGYP-----DCSVTF---PDEGGKPGQKK 604 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRK--LHVCGNNPT-CDGYEIEEGEFR 700 + C KCG + + K C C ++ Sbjct: 605 -----PVEVSNFACVKCGNPLKHLVKKGKGGYDFWGCSGFKEGCKATYEDKKGKP 654 Score = 75.1 bits (183), Expect = 1e-11, Method: Composition-based stats. Identities = 19/107 (17%), Positives = 40/107 (37%), Gaps = 8/107 (7%) Query: 691 GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVA 749 ++ ++ P C++CG + G+ G + C+ +C T + Sbjct: 543 HDQLNMELSTLQVSATPKHPCQECGKPLRRIPGKNGHFWGCSGYPDCSVTFP---DEGGK 599 Query: 750 PPKEDPVPLPELPCEKSDAYF--VLRDGAAG-VFLAANTFPK-SRET 792 P ++ PV + C K +++ G G F + F + + T Sbjct: 600 PGQKKPVEVSNFACVKCGNPLKHLVKKGKGGYDFWGCSGFKEGCKAT 646 Score = 66.7 bits (161), Expect = 4e-09, Method: Composition-based stats. Identities = 21/96 (21%), Positives = 35/96 (36%), Gaps = 8/96 (8%) Query: 659 KRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE--CEKCGS 716 K C +CG + + C P C +EG + + C KCG+ Sbjct: 560 KHPCQECGKPL-RRIPGKNGHFWGCSGYPDCSVTFPDEGGKPGQKKPVEVSNFACVKCGN 618 Query: 717 EM--HLKMGRFG-KYMACTN--EECKNTRKILRNGE 747 + +K G+ G + C+ E CK T + + Sbjct: 619 PLKHLVKKGKGGYDFWGCSGFKEGCKATYEDKKGKP 654 >UniRef50_D0JAY2 DNA topoisomerase n=2 Tax=Blattabacterium RepID=D0JAY2_BLASB Length = 704 Score = 507 bits (1305), Expect = e-141, Method: Composition-based stats. Identities = 232/685 (33%), Positives = 350/685 (51%), Gaps = 79/685 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESP KA TI +LG DY V SS GHI DLP Sbjct: 1 MKENLVIVESPTKAYTIQTFLGKDYYVVSSYGHIIDLPE--------------------- 39 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GV+ N++ +Y +L K+K+V LK L + I+LA+D DREGEAIA Sbjct: 40 --------KEIGVEIKDNFKPNYVILSKKKKIVQNLKILIKNHKIIWLASDEDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 + + + D +Y R+VF+EITK AI A P +N D V AQQARR +DR+VG+ +S Sbjct: 92 YQIYKTFNIPDRKYRRIVFHEITKKAIFNAIKNPRSINYDLVYAQQARRILDRLVGFQLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ RGLSAGRVQS AV+L+VE+E +I+ F+P ++V + ++ Sbjct: 152 PVLWKKVKRGLSAGRVQSAAVKLIVEQENKIQKFIPSPTYQVYGVFSNEQKMIFNAKLDK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + + N +SL + + V + K P PF TS+LQQ A +L + Sbjct: 212 KIEDKKKMKN------ILSLCINSSFLVKKIVIKHEKKNPPPPFTTSSLQQEACKKLNYS 265 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 + KTM +AQ+LYE G+ITYMRTDST+LS+D ++ ++ YI +GKKYL K Sbjct: 266 ISKTMFLAQKLYEKGFITYMRTDSTSLSKDILSEIKDYILSLYGKKYLSTKEFSKGQKF- 324 Query: 361 SQEAHEAIRPSDVNVMAES-LKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD 419 SQEAHE+I P+ +N + + L ++ ++LYQLIW + + QM + + + + Sbjct: 325 SQEAHESIHPTVINHIDNNYLNFLDIYQKRLYQLIWERTIMGQMIDSVIEKKDFYIQSSH 384 Query: 420 FR--LKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARF 477 F R + DG+ K++ E + + +G L E+ Q R+ Sbjct: 385 FDDFFIWTKRTVLLDGFMKIVNQDENKKEKLSVLEMKQGTHLQRKEIIAKQIIPSRIHRY 444 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYV--------------------------- 510 +EASLV LEK GIGRPSTY IIS IQ R YV Sbjct: 445 NEASLVNNLEKLGIGRPSTYVPIISAIQKRNYVSIQKIIKKTETRKNFLLKGNSIIEKNE 504 Query: 511 ---RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 +E +F ++G ++T+ L++NF E+++Y+FTA +E + D +A + W +L +F Sbjct: 505 QITEIEKNKFIPTEIGVLITNFLKKNFAEIVDYNFTANLEKNFDDIAKGKQSWIKILQNF 564 Query: 568 FSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPK 627 + +F +++ EE + ++ ID P +K+ + A G + + K Sbjct: 565 YDEFHKKIQYV----EEYVDKIHKERFLGID-PKSNKKIFSKIARFGPIVQMGEFKDKEK 619 Query: 628 ERC-----KTTINLVPENEVLNVLE 647 + TIN + E L +LE Sbjct: 620 PKFSPLLNSQTINTISFTEALKILE 644 >UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP1_PYRHO Length = 686 Score = 505 bits (1300), Expect = e-141, Method: Composition-based stats. Identities = 179/739 (24%), Positives = 302/739 (40%), Gaps = 105/739 (14%) Query: 4 ALVIVESPAKAKTINKYL---------------------GSDYVVKSSVGHIRDLPTSGS 42 L+I E P A+ I L G +V S+VGH+ L Sbjct: 2 ILIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLA---- 57 Query: 43 AAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQL--- 99 PK+D G + + W Y GKE +K L Sbjct: 58 ----------------PKRDVFGYPIFDI------EWVPVYIAEKGKEYAREYIKALSVL 95 Query: 100 AEKADHIYLATDLDREGEAIAWHLREVIGGDDARY-SRVVFNEITKNAIRQAFNKPGE-L 157 A++ +A D D EGE I + + G D R R+ F+ +TK + A+ + Sbjct: 96 AKRVREFIVACDYDTEGEVIGYTALKYACGVDPRVAKRMKFSALTKRDLLNAWRNLEPTI 155 Query: 158 NIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREI 211 N NA AR +D G +S L I + LS GRVQ ++ +VEREREI Sbjct: 156 NFGMANAGIARHILDWYWGVNLSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREI 215 Query: 212 KAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLER 271 ++FVP +W + + A N + + +E+ + V ++K+ V Sbjct: 216 QSFVPRPYWVIKLIFEKNGQKFTA------NYEKDKIWEEEEGKRIVLEVKKSIPRVSNV 269 Query: 272 EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD- 330 E K P PF TLQ+ A + GF KKT+ +AQ LYE G+ +Y RT+S L ++ Sbjct: 270 EIKRQKRTPPHPFDLGTLQREAYSAFGFSPKKTLDIAQSLYEKGFSSYPRTESQKLPRNI 329 Query: 331 -----AVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEA 385 N+ + + L + + AH AI P+ D+ Sbjct: 330 NFRMIIQNLAKMPQYRPYAHILLGLPELKPVEGKKEDPAHPAIYPTGEIPRP---GDLTK 386 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD 445 D +KLY +I R+F+A M PA +S +T+ AG + G GW V K Sbjct: 387 DEEKLYDMIVRRFLAVFMEPAIRESVKVTIRAGPHKFFLSGGRTVKKGWLSVYGKYVKF- 445 Query: 446 EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQ 505 E+ LP G+ + ++++ + TKPPAR+S A+++K++E G+G +T A I+ T+ Sbjct: 446 EEVTLPEFFIGERIKVIQVKREKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLY 505 Query: 506 DRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD 565 RGY+ + +G V + LE+ E+++ + T + E ++ + + V++ Sbjct: 506 QRGYIE-GKKSIKVTPLGMKVIETLEKYVPEIISVELTREFEKKMELIMEGRLTKEEVIE 564 Query: 566 HFFSDFTQQLDKAEKDPEEGGMRPNQMVLTS--------IDCPTCGRKMGIRTAST--GV 615 T+ L++ +K E G+ ++V+ CP CG + ++ Sbjct: 565 EAKERLTKILEEFKKRELEIGIELAKIVVGEDEVKPLVVGKCPKCGGDLIVKYNKKTGKR 624 Query: 616 FLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLID 675 F+GCS + +C T ++ E++ + G + + Sbjct: 625 FVGCSNWP-----KCDVTYPILQRGEIIPTNKTCCN--------------GAPVVIIREE 665 Query: 676 PKRKLHVCGNNPTCDGYEI 694 R+ +C + C ++ Sbjct: 666 DGREFEICLD-INCKDWKA 683 Score = 42.4 bits (98), Expect = 0.076, Method: Composition-based stats. Identities = 8/49 (16%), Positives = 19/49 (38%), Gaps = 2/49 (4%) Query: 746 GEVAPPKEDPVPLPELPCEKSDAYFVLRDGAA--GVFLAANTFPKSRET 792 ++ +++ PL C K +++ F+ + +PK T Sbjct: 589 AKIVVGEDEVKPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVT 637 >UniRef50_C1MSJ2 DNA topoisomerase n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MSJ2_9CHLO Length = 1243 Score = 502 bits (1293), Expect = e-140, Method: Composition-based stats. Identities = 251/835 (30%), Positives = 375/835 (44%), Gaps = 148/835 (17%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 + LVIVESPAKA ++ KYLG Y V +S GH+RDL + Sbjct: 98 RTLVIVESPAKATSVQKYLGQSYQVLASYGHVRDLVEKQGS------------------- 138 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADH-IYLATDLDREGEAIAW 121 V P + + L GK VV + + AE+ + LATD DREGEAIAW Sbjct: 139 ----------VLPDDGFAMRWS-LQGKSGVVKSIVESAERCGGGVVLATDPDREGEAIAW 187 Query: 122 HLREVIGGDDAR--------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 H+ E++ +R SRV F E+T++A+ +AF +P E++++ V+A ARR +D Sbjct: 188 HISELLKERGSRKKKDAPTAISRVTFTEVTRDAVVKAFKEPREISVELVHAYLARRALDY 247 Query: 174 VVGYMVSPLLWKKI--ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 + G+ +S +LW+KI + LSAGRVQS A+RL+ ERE I+ V EE+W V A SG Sbjct: 248 LFGFKLSGVLWRKIPSSERLSAGRVQSAALRLICEREMSIERHVKEEYWSVVAGLERASG 307 Query: 232 EALA-------------LQVTHQNDKPFRPVNKEQTQAAVSLLEKARYS--VLEREDKPT 276 + + +K+ +A + + A+ + V E+K Sbjct: 308 VKKSDGDASGRFVAELHRDASGARLAKGAVNSKQIAEAVSNEILAAKDTLYVATVEEKEA 367 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-----GYITYMRTDSTNLSQDA 331 T+KP PF TSTLQQ A+ +LGFG +TM AQ+LYE G ITYMRTD ++ DA Sbjct: 368 TTKPKPPFTTSTLQQEANAKLGFGSARTMSAAQKLYEGKGFGEGLITYMRTDGLHVGPDA 427 Query: 332 VNMVRGYISDNFGKKYLPESPNQYAS-KENSQEAHEAIRPSDVNVMAESLK---DMEADA 387 V +R ++ FG Y+P +PN Y ++N+QEAHEAIRP ++ ++ +D Sbjct: 428 VKAIRAVATEEFGASYVPATPNAYKKTQKNAQEAHEAIRPIRAELLPNAVSARLGANSDE 487 Query: 388 QKLYQLIWRQFVACQMTPAKYDSTTLTVGAG----DFRLKARGRILRFDGWTKVM----- 438 +LY+LIW + +A QM+ A V + + LKA G L F G+ Sbjct: 488 ARLYKLIWSRTMASQMSRAVTRRIAAEVKSASEGCELALKANGSRLLFSGFLAAYAHGGR 547 Query: 439 --PALRKGDEDRILPAVNKGDALTL----------------------------------- 461 + D LP + GD + L Sbjct: 548 TSGDDDRDKRDAWLPELKPGDTINLRAPQSVRVIERDKDAKRGGLAKKKSDQADDEDAVD 607 Query: 462 -----------VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 +T QH+T+PPAR++E +LV+ +E++GIGRPSTYASI+ + RGYV Sbjct: 608 VSETLSSVDTSAGITALQHWTQPPARYTEGALVRAMEEKGIGRPSTYASIVKVMLKRGYV 667 Query: 511 RVENRR--FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 + E G +V+ L F E ++Y FTA +E+ LD +A+ +AEWK V+ F+ Sbjct: 668 VGGGGKGPLIPETRGRMVSSFLTHFFDEYVDYGFTAGLEDKLDDIASGDAEWKDVMSKFW 727 Query: 569 SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL-GCSGYALPPK 627 F + + +V+ +D G + T L + A PP+ Sbjct: 728 KPFHGDVQGLQNIR-------TSLVVDVLDATLGAHFFGDDESETKARLDAIAATAEPPR 780 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNN- 686 + + + D + LRA RRCP C + C N Sbjct: 781 SE----GDAAAPKRAGDAWKSPDYDPATLRASRRCPACVDGRLGLKLSKNGGFIGCSNYN 836 Query: 687 --PTC---------DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 C +G + E DG I + + ++ G +G Y+ Sbjct: 837 TDTKCAYARPISTTNGDDAESMRTDPWLSDGEIGVDPETSRTVSVRRGPYGPYVQ 891 >UniRef50_Q04TE1 DNA topoisomerase n=4 Tax=Leptospira RepID=Q04TE1_LEPBJ Length = 613 Score = 502 bits (1293), Expect = e-140, Method: Composition-based stats. Identities = 204/639 (31%), Positives = 335/639 (52%), Gaps = 59/639 (9%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 +L+IVESP+KAKTI YLG ++ + +++GH+ DLP + Sbjct: 3 SLIIVESPSKAKTIGGYLGKEFRILATLGHVADLPKT----------------------- 39 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +G+D + +E Y VLPGK+K++SE+ + A+++ I+LATD DREGE I+ ++ Sbjct: 40 ------TLGLDLKNRFEPEYVVLPGKKKILSEIIKAAKESQRIFLATDPDREGEFISAYI 93 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 R+ + + R+ F EIT+NAI + P ++ V AQ+ RR DR++GY +SP+L Sbjct: 94 RDRLK-KKSNVFRIRFTEITRNAILSSLQNPDTIHESLVEAQKTRRVGDRLIGYFISPVL 152 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 W++I GLSAGRVQSVA++ + +RE EI+ F E ++ V G Q Sbjct: 153 WREIGPGLSAGRVQSVALKWICDREDEIRNFHSEIYYNVLLYVHDKKGIEGVFQRVGD-- 210 Query: 244 KPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 R ++E+ + ++K + + E+++ + P PF T++LQQ A +L F K Sbjct: 211 ---RIFSEEKANLILQNVQKEKNLRISEKKESHKKNLPPPPFQTASLQQEAFRKLRFSSK 267 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 KTM +AQ+LYE G ITYMRTDS LS D V +I FG+ + + Sbjct: 268 KTMSIAQKLYEGMDLGNGKREGLITYMRTDSVRLSPDFVERANSWIISEFGETFANKLER 327 Query: 354 QYASKENS-QEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 + Q+AHEAIR +D + +ES K+ + + LY+LIW++ ++ + P ++ +T Sbjct: 328 KVKKSSKKIQDAHEAIRITDPFLTSESAKNFLGKEEASLYELIWKRTISYLLPPEEFLNT 387 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 ++ + + F G+ + A +K + P KG+ LTL + + T Sbjct: 388 EYSIFVAGEYFQLETKKTLFPGYKILNEADKKAN-----PNWEKGELLTLQKAECEKKQT 442 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 +P R+SE +LV +LE+ GIGRPSTY+++ + R YV E + FY +GE V L+ Sbjct: 443 EPSPRYSEGTLVAKLEREGIGRPSTYSTVSEILVKRKYVEQEKKFFYPLPLGEKVNFFLQ 502 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE-----KDPEEGG 586 F +L FTA++E++LD++ +E + +L+ +SD Q+ ++ E Sbjct: 503 SGFGDLFREKFTAELESNLDRIEKNEIDSLVILNRLWSDLQTQIQNSKFVASVFRKEWAE 562 Query: 587 MRPNQMVLTSIDCPTC--GRKMGIRTASTGVFLGCSGYA 623 +R + + CP C G +T+ F CS + Sbjct: 563 IREKKKETSWGICPLCRDGSLQKKKTSRKKEFYQCSRFP 601 >UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8VXL1_DESAS Length = 746 Score = 502 bits (1293), Expect = e-140, Method: Composition-based stats. Identities = 159/774 (20%), Positives = 282/774 (36%), Gaps = 140/774 (18%) Query: 3 KALVIVESPAKAKTINKYLGSD-----------YVVKSSVGHIRDLPTSGSAAKKSADST 51 K LV+ E P+ A+ ++ LG+ Y++ ++GH+ L Sbjct: 2 KQLVLAEKPSVARDLSNVLGNFNKGNGYLESDAYIITWAIGHLVTLAEPDDYDAALKKWF 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADH--IYLA 109 P+ E + + K + +K L + D I A Sbjct: 62 LNTLPILPR-------------------EFKLKPVSATLKQFNIVKSLLHRNDVGDIICA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI--DRVNAQQA 167 TD REGE I ++ + + + R+ +E T A+R+ F+ N A +A Sbjct: 103 TDSGREGELIFRYIYK-LTDCQKPFKRLWLSETTPAAVRKGFDNLRPGNDLDRLAFAAEA 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D ++G + K + LS GRVQ+ + L+V RE+EI+AFVPE++WE+ A T Sbjct: 162 RSQADWLIGINATRAFTVKHNQLLSVGRVQTPTLALIVNREQEIRAFVPEKYWELFALFT 221 Query: 228 TPSGEALALQVTHQNDKPFRPVN------------------------------------- 250 +G+ + + K Sbjct: 222 KENGQTYIGKWFKKEKKAVENWEIPIQVGQKQTNQNPAASFEAAQGGIPSVMGEAVPSSN 281 Query: 251 --------------KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 +E + + V+ E K P F + LQ+ A+ + Sbjct: 282 GQDKPVAMQTKFAAREAARDIQKKVTGQPGQVVSVEKKDIIEHPPLLFNLNDLQKEANKK 341 Query: 297 LGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGYIS--------DNFGKKY 347 G KT+ +AQ LYE ITY RTDS ++ + + + +NF Sbjct: 342 FGLSAAKTLSVAQELYESRKLITYPRTDSRCITVEMGKTIPQRLGALAVVAEYENFIHLI 401 Query: 348 LPESP--NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTP 405 N+ ++ H A+ P++V L + +D +++Y L+ R+F+A P Sbjct: 402 KERKAFLNKRYINDSKVTDHTALIPTNV---KPDLDKLSSDERRVYDLVVRRFLAAFFPP 458 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG---DEDRILPAVNKGDALTLV 462 A+Y+ T + +RGR+ GW V ++ DE ILP + +++ Sbjct: 459 ARYEQTQVITEVKQETFLSRGRVELDKGWKTVYDPVQDKLVDDEQGILPVIENEESVLTT 518 Query: 463 ELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRPSTYASIISTIQD 506 + + T PP R++EA+L+ +E G+G P+T A+II + Sbjct: 519 KTDIKEKKTNPPKRYTEAALLSVMEGAGRLLNDEELKEAMRGSGLGTPATRAAIIERLLK 578 Query: 507 RGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 GY+ + + GE + + E + + + TA+ E +L + + + + Sbjct: 579 VGYIERRKKTLLPTEKGENLIKLVPEQVK---SPEMTARWEKALADIEDGQLNPGEFMSG 635 Query: 567 FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPP 626 Q ++ A + EG N + CP CGR + CS Y Sbjct: 636 IIEQTRQVVELARRQKTEGEPLRNNRDIIG-KCPLCGRPVV----EYPKSYSCSDY---- 686 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 + C+ I V + + V K+ ++ +K Sbjct: 687 RAGCQFVIWKVILGKNITVEMARILLEKGRLEKQP---------GFISKNGKKF 731 >UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3_BACAH Length = 729 Score = 502 bits (1292), Expect = e-140, Method: Composition-based stats. Identities = 173/731 (23%), Positives = 299/731 (40%), Gaps = 94/731 (12%) Query: 1 MGKALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M K++VI E P+ A+ I + L GS Y+V ++GH+ L S K Sbjct: 1 MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKK 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQ--LAEKADHIY 107 P++ V+ K + +K L + + I Sbjct: 61 WNLEDLPMLPER-------------------LKLTVIKQTGKQFNAVKSQLLRKDVNEII 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQ 165 +ATD REGE +A + + + + R+ + +T AI+ F PG+ + + Sbjct: 102 VATDAGREGELVARWIIDKVRI-NKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D +G + L + L+ GRVQ+ V ++ RE EIK F + ++ ++A Sbjct: 161 VARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQ 220 Query: 226 TTTPSGEALALQVTHQN-DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPF 284 TT L++T Q+ + R NKE+ V L+K +VLE + K S + Sbjct: 221 TTNQ------LKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLY 274 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYISDNF 343 + LQ+ A+ + G+ K+T+ + Q+LYE + TY RTDS +S D V + + Sbjct: 275 DLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACG 334 Query: 344 GKKY---------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 +Y P N+ ++ H AI P++ V + +K+Y L+ Sbjct: 335 VGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYV---NFSAFTDKERKIYDLV 391 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE------DR 448 ++F+A +Y+ TL G+ ARG+ + GW +V + D+ ++ Sbjct: 392 VKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQ 451 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK-------------------R 489 +LP + KGD LT+ + TK PARF+EA+L+ +E Sbjct: 452 LLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTG 511 Query: 490 GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENS 549 G+G +T A II + + + + + G + D + E EL + T + E Sbjct: 512 GLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPE---ELKSPTLTGEWEQK 568 Query: 550 LDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIR 609 L+ +A + + + + ++T+++ K ++ N +++ CP CG+ M Sbjct: 569 LEAIAKGKLKKEVFISE-MKNYTKEIVSEIKSSDKKYKHDN---ISTKSCPDCGKPMLEV 624 Query: 610 TASTGVFLGC-SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 G L C K +TT P+ + L GE C KCG Sbjct: 625 NGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKLELRGE-----GAGQIFAC-KCGYR 678 Query: 669 MDSYLIDPKRK 679 +RK Sbjct: 679 EKLSTFQERRK 689 Score = 55.1 bits (131), Expect = 1e-05, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 37/112 (33%), Gaps = 19/112 (16%) Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 EI+ + + K + C CG M G+ GK + C + EC + + + R Sbjct: 596 EIKSSDKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRT------- 648 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKS--RETRAPLVEELYR 802 C + LR AG A K RE + E + Sbjct: 649 ------TNARCPQCKKKLELRGEGAGQIFAC----KCGYREKLSTFQERRKK 690 >UniRef50_Q185E5 DNA topoisomerase n=10 Tax=Clostridiales RepID=Q185E5_CLOD6 Length = 706 Score = 502 bits (1292), Expect = e-140, Method: Composition-based stats. Identities = 161/711 (22%), Positives = 278/711 (39%), Gaps = 81/711 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSD-----------YVVKSSVGHIRDLPTSGSAAKKSAD 49 MGK LV+ E P+ + I K LGS YV+ ++GH+ L S ++ Sbjct: 1 MGKILVLAEKPSVGRDIAKVLGSKNEKNGYIEGPKYVITWALGHLVTLADPESYGERYKS 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK--ADHIY 107 + PK + V+ K + +K + D I Sbjct: 61 WSLEDLPILPKHLKT-------------------VVIKKSGKQFNTVKSQMNRNDIDEIV 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQ 165 +ATD REGE +A + E R+ + T AI+ F K G+ + + Sbjct: 102 IATDAGREGELVARWIIEK-SQVKKPIKRLWISSSTDKAIKDGFAKLKSGKEYENLYYSA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D ++G + L K LS GRVQ+ + ++++RE EI+ F P+E++ ++ Sbjct: 161 IARAEADWIIGINATRALTTKYNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLELI 220 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 T + + + N+ +KE+ ++ + ++ + E A + Sbjct: 221 ATKGNSDIKFIWNDKNNNS--STFSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPALYD 278 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYISDNFG 344 + LQ+ A+ GF K+T+ + Q+LYE + TY RTDS L+ D V ++ I Sbjct: 279 LTELQRDANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIKAVNI 338 Query: 345 KKY------LPES---PNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 Y L +S N+ + H AI P++ V + D +K+Y L+ Sbjct: 339 SDYSKICNRLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVF---MSDFSDKERKIYNLVV 395 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNK 455 ++F+A P +Y+ TT++ KA+G + GW + + DE +P V + Sbjct: 396 KRFLAVLSPPFEYEQTTISATVEGEIFKAKGNKVINLGWKESYKDIEDEDEYESIPNVLE 455 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 D L + L T PP +E +L+ +EK G+G +T A II + + + +N+ Sbjct: 456 KDVLKVKGLKITSGKTNPPPYLNEGTLLTAMEKNGLGTVATRADIIEKLFNSFLMEKKNK 515 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 Y G + D + +L + TA E L ++ + ++ D+++ + Sbjct: 516 DIYITSKGRQLLDLVP---VDLKTPELTASWEKKLLDISKGKLSKNTFIND-MKDYSKDI 571 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 K+ + N LT CP CG+ M G L C C T Sbjct: 572 VLEVKNSDNKFKHDN---LTKNRCPECGKFMLEVNGKKGKMLICE------DRECNT--- 619 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNN 686 +T + RCP C ++ R Sbjct: 620 ---------------RKTISQVTNSRCPNCHKKLELRGEGEGRIFTCSCGY 655 Score = 51.6 bits (122), Expect = 1e-04, Method: Composition-based stats. Identities = 20/119 (16%), Positives = 39/119 (32%), Gaps = 17/119 (14%) Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 E++ + + K + C +CG M G+ GK + C + EC + I + Sbjct: 574 EVKNSDNKFKHDNLTKNRCPECGKFMLEVNGKKGKMLICEDRECNTRKTISQ-------- 625 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAAN-TFPKSRETRAPLVEELYRFRDRLPEK 810 + C LR G + + RE + + + + +K Sbjct: 626 -----VTNSRCPNCHKKLELRGEGEGRIFTCSCGY---REKLSSFNKRKQEEKQKASKK 676 >UniRef50_C8WG68 DNA topoisomerase type IA central domain protein n=9 Tax=Coriobacteriaceae RepID=C8WG68_EGGLE Length = 849 Score = 500 bits (1288), Expect = e-140, Method: Composition-based stats. Identities = 202/851 (23%), Positives = 335/851 (39%), Gaps = 121/851 (14%) Query: 4 ALVIVESPAKAKTINKYLG---------------------SDYVVKSSVGHIRD---LPT 39 LV+ E A+ I LG ++V GHI + PT Sbjct: 2 KLVVTEKNDAAQKIADLLGVKKPKADKVYSTPVYRFDVDGEEWVTIGLRGHILEPDFAPT 61 Query: 40 SGSAAKKSADSTSTKTAKKP------------------KKDERGALVNRMGVDPWHNWEA 81 + + + P +D +M P+ + Sbjct: 62 MVYKKRGGWQGVTEEGETLPAELPASLPKPPFKKKKPFTEDGVELKSWKMDALPYLVYAP 121 Query: 82 HYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDA--RYSRVVF 139 LP +++++ LK LA+KAD + +ATD DREGE I I + SR + Sbjct: 122 -INKLPKEKEIIRSLKNLAKKADSVIIATDFDREGELIGSDALSCIQEVNPTAPVSRARY 180 Query: 140 NEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWK----KIARGLSAGR 195 + TK I AF+ EL+++ +A +R+ +D + G +++ L S+GR Sbjct: 181 SAFTKEEITHAFDNLVELDVNLASAGASRQDIDLIWGAVLTRYLTLVKFAGYGNVRSSGR 240 Query: 196 VQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQ 255 VQ+ + LVV RERE AFVPE++W + + A T R + + Q Sbjct: 241 VQTPTLALVVARERERLAFVPEDYWVIRGAFGADPDSFEAPHAT------ARFKAEAEAQ 294 Query: 256 AAVSLLEKA-RYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA 314 A ++ +E A R +V E K T +P APF T++L AAS G +TM +A+ LY Sbjct: 295 AVMAHVEGATRATVASVEKKKRTVQPPAPFNTTSLMAAASAE-GLSPARTMRIAESLYMD 353 Query: 315 GYITYMRTDSTNLSQ--DAVNMVRGYISDN----FGKKYLPESPNQYASKENSQEAHEAI 368 GYI+Y R D+T D + V+ + + K+ L + + H I Sbjct: 354 GYISYPRVDNTVYPSSLDLADTVKAISGNPAYAPYCKELLAKGKLTATRGKKETTDHPPI 413 Query: 369 RPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRI 428 P+ + D+ KLY LI R+F+A A + T +T+ A+G + Sbjct: 414 YPT----AKATPDDLAPADYKLYNLIARRFLATLSEAAVIEGTKVTLDVNAEPFVAKGDV 469 Query: 429 LRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK 488 L G+ + P K DE LPA+++G+ + + T+PPAR+S+ L++E+EK Sbjct: 470 LVKPGYRAIYPYGLKKDEQ--LPALSEGETVAFNGAVCTKKQTEPPARYSQGKLIQEMEK 527 Query: 489 RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN 548 G+G ST +II + Y N ++G V D L++ + + + TA++E Sbjct: 528 LGLGTKSTRHAIIERLYAVKYCM--NDPIEPSQLGMAVCDALDKFAPHITHPEMTAELEE 585 Query: 549 SLDQVANHEAEWKAVLDHFFSDFTQQLDKA---EKDPEEGGMRPNQMVLTSIDCPTCGRK 605 +D +A V+D + ++QL ++ +E CP CG+ Sbjct: 586 EMDNIAEGRTTKAQVVDTSRNLLSEQLASLLPHSEEVKEALADAVAADAYVGPCPKCGKD 645 Query: 606 MGIRTASTGV--FLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCP 663 + +R + F+GC+G+ C T L + CP Sbjct: 646 LQLRASQKTRSMFIGCAGWP-----DCDVTYPL--------------PKGKVEAVPEPCP 686 Query: 664 KCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSE------ 717 CG + +C + P C + D + EC C + Sbjct: 687 TCGMPQVKVTAFRSKPRTICID-PHCSTNQEP---------DVVVGECPACKEKGIQAKL 736 Query: 718 MHLKMGRF-GKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDG 775 + K R +++ C N ++C + + G + E CE A V+ Sbjct: 737 IAQKNPRTLKRFIRCENYDDCGTGYPLPQYGALTA--------TEEVCEHCGAPMVIVTT 788 Query: 776 AAGVFLAANTF 786 A G + F Sbjct: 789 ARGPWKLCPNF 799 >UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria RepID=C4NUW5_ECOLX Length = 730 Score = 500 bits (1288), Expect = e-140, Method: Composition-based stats. Identities = 173/764 (22%), Positives = 277/764 (36%), Gaps = 112/764 (14%) Query: 5 LVIVESPAKAKTINKYL------------GSDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 L I E P++AK + + G + V+ + GH+ +L ++ + Sbjct: 3 LYICEKPSQAKDLAGVMKASQRGDGFLHDGGNRVITWAFGHLLELYMPDDYDERYKSWSL 62 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 P+ Y V K ++ L +KA IY++TD Sbjct: 63 ETLPIAPE-------------------SWRYNVRKSAFKQYKIVEGLVKKASTIYISTDY 103 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRF 170 DREGEAIA L + RV + +++I++A N G+ + A AR+ Sbjct: 104 DREGEAIARSLLDRFRYS-GPIRRVCLTALDESSIKKALNNVKDGKDTVSLYYAALARQR 162 Query: 171 MDRVVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 D +VG VS L L GRV + V LV +R+REI F P +W + + Sbjct: 163 ADWLVGMNVSRLYTVLARDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVN 222 Query: 226 TTTPSGEALALQVTHQN--DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 + +G+ A + + D+ R VNK + S + A + + E KP P Sbjct: 223 VSVQNGQFAAQWIPPEECSDEQGRCVNKAYAEQVASQVNGANAVISKAETKPGKESAPLP 282 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGYIS-- 340 F ++LQQ AS R G+ ++ + AQ LYE TY RTDS L + + + Sbjct: 283 FDLTSLQQYASKRWGYTAQQVLDAAQALYETHKATTYPRTDSRYLPESQKEDIPDILQAL 342 Query: 341 ----DNFGKKYLPESPNQYAS--KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 N P++ A + AH AI P+ + M LY I Sbjct: 343 ILSDQNVSGLVAGADPHRKARVFNDAKVTAHHAIIPTPART---DISAMSEIEFNLYDAI 399 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD--------- 445 R ++A + ++ T++ V G + G+ GW + + + Sbjct: 400 RRFYIAQFYSEFEFTKTSIEVQCGRHLFASAGKTPTKQGWKVLFASDSESSPKDEGEDTD 459 Query: 446 ---EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK-------------- 488 E LP V++G+ L A T+P F+EA+L+ +E Sbjct: 460 APVEQEKLPRVSQGEPALLNGAELANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQIL 519 Query: 489 ---RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQ 545 G+G P+T ASII D+GY + + + A + L + + TA Sbjct: 520 KDTAGLGTPATRASIIQGAVDKGYFKRQKKVLLATDKAHALIAVLP---PAIKSPGMTAA 576 Query: 546 MENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE-------KDPEEGGMRPNQMVLTSID 598 E L++VA+ + + Q +++ + K+ S + Sbjct: 577 WEQELEKVASGSGNMSVFMKQISTWICQMVEQLKVAAPVLTKEGGAMAKAFEGAKPPSHE 636 Query: 599 CPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRA 658 C CG +M G F GC E CK T G+ + A Sbjct: 637 CFNCGGEMHRIKGKNGFFWGCQN------EACKKTFPDN---------RGKPEKRIAAED 681 Query: 659 KRRCPKCGTAMDSYL-----IDPKRKLHVCGNNPTCDGYEIEEG 697 CP CG+ M K C P C G + Sbjct: 682 CPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTMPFKK 725 >UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae RepID=B4EXZ8_PROMH Length = 684 Score = 498 bits (1281), Expect = e-139, Method: Composition-based stats. Identities = 171/697 (24%), Positives = 276/697 (39%), Gaps = 95/697 (13%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 L + E P++AK I + +G + V + GH+ + + + A Sbjct: 2 KLFLCEKPSQAKDIARVIGAHQRRDNFFQGNGVQVAWARGHLLEQAEPEAYGAQFA---- 57 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 R P + V + +KQL +A + +ATD Sbjct: 58 --------------APWRQSALPVIPEQWKMVVKKDAVSLFQTIKQLLSQATEVVIATDA 103 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRF 170 DREGE IA L E + R+ + + + +IRQA N PGE +A R Sbjct: 104 DREGEVIARELLEACH-YRKKVQRLWLSALDEASIRQALNNLLPGEKTASLYSAGLGRAR 162 Query: 171 MDRVVGYMVSPLLWKK-----IARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 D ++G ++ L K LS GRVQ+ + L+V REREI FV + FW V AS Sbjct: 163 ADWLIGMNMTRLFTLKARELGFGGILSVGRVQTPTLALIVRREREITHFVSKPFWRVTAS 222 Query: 226 TTTPSGEALALQ--VTHQNDKPFRPVNKEQTQAAVSLLEKA-RYSVLEREDKPTTSKPGA 282 A + D R ++ + QA L +A + +V + + P Sbjct: 223 LQHQGIIFQAHWRPASQYCDDEHRCIHVQAAQAVEQLCRQAGKATVCTVNETKGKALPPL 282 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYI-- 339 PF TLQQAAS R G+ K + +AQ LYE TY RTD L + + Sbjct: 283 PFDLGTLQQAASRRWGYSADKVLEIAQSLYEKHKATTYPRTDCGYLPVSMRADIPVVLDA 342 Query: 340 ---SDNFGKKYLPE-SPNQYASKEN--SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 SD + L + P + + N AH AI P+ L M +Y+L Sbjct: 343 LSQSDPALQNVLAQLQPARISRVWNDAKITAHHAIIPT---RQTPDLNAMNEAELNVYKL 399 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------PALRKGDE- 446 I ++A + ++D+T + + G + A+G++ R GW+ + P +++ E Sbjct: 400 IRAHYLAQFLPDQEWDATEVFLDIGGQQFVAKGKVERVKGWSVLFVKHEDDPPVKEEAET 459 Query: 447 -----DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL--------------- 486 LP++++G+ + E Q T PP +++ +L+ + Sbjct: 460 GLEAGTETLPSLHEGEFCVVQEAKVVQLATSPPKPYTDGTLIAAMKNASSFITDPTLKKV 519 Query: 487 --EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTA 544 E G+G +T A II+T+++R + + + A G + D L + TA Sbjct: 520 LKENAGLGTEATRAGIITTLENRKLIVRQKKTLRATDTGCQLIDALPAAC---TDPGMTA 576 Query: 545 QMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGR 604 E SL+QVA + S + K + P + P CP+C Sbjct: 577 LWEQSLEQVAQGNLSLDVFMQKQISWLAHLIKKGGEMPLALDLPPMP------SCPSCHG 630 Query: 605 KMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENE 641 KM +R +S G F C Y CK ++ L + + Sbjct: 631 KMVLRESSKGRFWSCQRYP-----DCKGSVPLPEKMQ 662 Score = 56.3 bits (134), Expect = 5e-06, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 27/60 (45%), Gaps = 3/60 (5%) Query: 742 ILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELY 801 +++ G P D P+P C VLR+ + G F + +P + + PL E++ Sbjct: 606 LIKKGGEMPLALDLPPMPS--CPSCHGKMVLRESSKGRFWSCQRYPDCKGSV-PLPEKMQ 662 Score = 45.1 bits (105), Expect = 0.012, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 21/50 (42%), Gaps = 1/50 (2%) Query: 697 GEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRN 745 GE + P+ C C +M L+ G++ +C +CK + + Sbjct: 611 GEMPLALDLPPMPSCPSCHGKMVLRESSKGRFWSCQRYPDCKGSVPLPEK 660 >UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LPU9_9EURY Length = 764 Score = 497 bits (1280), Expect = e-139, Method: Composition-based stats. Identities = 178/772 (23%), Positives = 318/772 (41%), Gaps = 58/772 (7%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 LVI E A+ I K L G R+ S + K + Sbjct: 19 NILVIAEKRNAAQRIAKILSGGRYETIKKG--RNAYYSFTKGKDRYFVVPLRGHILHMDY 76 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +G E +++ K + + L+ LA+ AD + +ATD DREGE I Sbjct: 77 PDKFKRWSLGDLQRLVDEEPIKIIKEKG-IANILRTLAKDADMLIIATDYDREGELIGVE 135 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 I R F+ +T+ I AF+ ++N + +A + R+ +D G ++ Sbjct: 136 SLS-ITNFKGPVKRAKFSALTEREIENAFSNLVDVNYNLASAAETRQKIDLAWGASLTRF 194 Query: 183 LWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 + +R LS GRVQS + L+V+RE+EI+ FVP +W + + Sbjct: 195 ISLASSRRGKDYLSVGRVQSPTLALIVKREKEIENFVPTPYWNIKGLFF----KRRNFSG 250 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 H ++ ++ +E + + + VL+ + +P PF T+ A T+LG Sbjct: 251 MHISNPFWK--EEEVMEVYEKVKDTKSAKVLDFVQEDRKIRPPIPFNTTEFLSEA-TKLG 307 Query: 299 FGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV--NMVRGYISDNFGKKYLP---ESPN 353 F K M +A+ LY GYI+Y RTD+T + ++++ F ++ L E Sbjct: 308 FSAAKAMRLAEELYMGGYISYPRTDNTVYPKTLSINSILKSLEKSKFKEEALKLQKERRR 367 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 + H I P+ ++E D K+Y+L+ R+F+A +Y + + Sbjct: 368 YPTRGKKESTDHPPIVPTRG-------ANLEGDKGKIYELVVRRFMATLAQDLEYRESKV 420 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKP 473 + D +A+G+ L +GW P +R E+ +P + GD + + ++ + T+P Sbjct: 421 KLAVKDEIFEAKGKELVNEGWLYYYPYVRF--EEEKIPILRIGDEVKVKKIEIERKETRP 478 Query: 474 PARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEEN 533 PAR++++SL++E+EK +G ST A II + +RGYVR ++G+ + + LE N Sbjct: 479 PARYTQSSLIREMEKLNLGTKSTRAEIIQKLFERGYVR--GNPIRPTQLGKALIESLEGN 536 Query: 534 FRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMV 593 +++ D TA++E +D++ + V+ + L E++ G + Sbjct: 537 NVDVIKPDMTARLEMDMDEIEKGSKAPEFVVKESREMLKKILSSLEENRSTVGSNIKSSM 596 Query: 594 LTSI-DCPTCGRKMGIRTASTGVFLGCSG------YALPPKERCKTTINLVPENE---VL 643 I +CP G+ + + + C Y LP + P + Sbjct: 597 RREIGECPDGGKLIYLERKR---LVVCENDGETKYYNLPKTGHIEFLDKKCPICGLPLIK 653 Query: 644 NVLEGEDAETNALRAK----------RRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE 693 + G+ E L +K +CPKCG + ++ C N P CD Sbjct: 654 IIRRGQSPEIRCLNSKCEYNRKKDIVGKCPKCGGDLVIRQSKNGKRFIGCSNYPKCDVTY 713 Query: 694 IEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK-YMACTNEECKNTRKILR 744 +I C CG+ + + + K + C N +C+ R+ Sbjct: 714 SLPQRGKII---PTGEVCPYCGAPLLILRKKGKKDWKFCPNIKCEYNRRNKD 762 >UniRef50_C6I107 DNA topoisomerase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6I107_9BACT Length = 739 Score = 496 bits (1278), Expect = e-138, Method: Composition-based stats. Identities = 164/759 (21%), Positives = 287/759 (37%), Gaps = 67/759 (8%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LVI E P+ A+ I +G +Y V ++ GHI +L + A P + Sbjct: 2 KLVIAEKPSMARAIKDVVGREYEVTNAFGHILELAEPDAY----------LPADVPVSIK 51 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 G + R P E + + + ++ +L +KAD + A D DREG+ + + Sbjct: 52 TGRKIWRACDLPILPAEWRQIPIRSSKDQLIKIGELLKKADLVVNAGDPDREGQLLIDEI 111 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQARRFMDRVVGYMVSP 181 + R RV + + K +I +AF + +A R D +VG ++ Sbjct: 112 LDHFR-YRGRVERVWLSALDKTSIDKAFRDLRDNRSYKPLSDAAMGRSRADWLVGMNLTR 170 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 S GRVQ+ + LVV R+ I+ F +++EV A G AL Sbjct: 171 AATLSSGSFYSIGRVQTPTLALVVHRDLAIERFAARDYFEVRARIRHERGTFSALWKPSD 230 Query: 242 -----NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 D+ R ++ Q + A+SL K + E K + P+ S LQ+AAS R Sbjct: 231 PSGPGFDEEGRLTDRRQAE-ALSLKGKGAGKISRYEKKEESKSAPLPYSLSALQKAASGR 289 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS----DNFGKKYLPESP 352 G + + Q LYE +Y RTD L + + + + + S Sbjct: 290 FGLSADEVLKTCQSLYEKKVTSYPRTDCRFLPVEQFSEAGRILQALPVSPDIRPLISASR 349 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 A AH AI P+ E D+ +K+Y +I ++A + +Y S Sbjct: 350 KHPAWNTAKVTAHPAIVPTG-----ERAGDLSEKERKIYDMIVSSYLALFLPDHRYFSAA 404 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMP-ALRKGDEDRILPAVNK---GDALTLVELTPAQ 468 L+V A GR GWT++ R+ + LP++ + G+A+ + Sbjct: 405 LSVEMNREIWTATGRQEIDPGWTRLFGRGDREEGGEEDLPSLPECRPGEAVLGEGGEVRE 464 Query: 469 HFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYASIISTIQDRGYVR 511 T+PP RF++ +L++ + E GIG +T A I+ T+ R Y+ Sbjct: 465 KKTRPPGRFTDGTLIEAMSNIHKFVEDPEAKQTLKETSGIGTEATRAGILETLVGREYIV 524 Query: 512 VENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 + ++ + + G + LE +L++ TA+ E+ L +V+ + +A + +D Sbjct: 525 RKGKQILSTEKGRSLVGFLEATLPDLVDPVTTARWEDDLSEVSAGKKRVEAFVGGI-ADL 583 Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK--MGIRTASTGV---FLGCSGYALPP 626 ++ + +GG+ + I CP CG + + R + F CS Sbjct: 584 VREQTRTLLTKGQGGLAGDPSSPAKIACPVCGGQALVTRRESRNKKGVFFWTCSQKTAAG 643 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKR-RCPKCGTAMDSYLIDPKRKLHVCGN 685 + P +V +E L + CP C + + C Sbjct: 644 EPV------HPPLTDVAGTPGAPFSEKPPLNSDGPPCPTCRKPLSAETTSKGTAYFRCA- 696 Query: 686 NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGR 724 +G+ + G + K G+ Sbjct: 697 ----EGHGPWWSDNGSPGNPWKPQSGTESAKGSFKKSGK 731 >UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae RepID=TOP1_METTH Length = 718 Score = 496 bits (1277), Expect = e-138, Method: Composition-based stats. Identities = 197/784 (25%), Positives = 337/784 (42%), Gaps = 118/784 (15%) Query: 5 LVIVESPAKAKTINKYL-------------------GSDYV-VKSSVGHIRDLPTSGSAA 44 ++I E P ++ I L G V + S+VGH+ L S Sbjct: 11 VIICEKPKSSEKIAGALFPDAMKKKHGKVSYWEHVEGDKRVTIVSAVGHLYSLRPRQSNE 70 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGK---EKVVSELKQLAE 101 + D W +E+ K + ++ +++ A Sbjct: 71 EHFFDLE---------------------------WAPIHEIDKKKGYVKDYLNVIRKFAA 103 Query: 102 KADHIYLATDLDREGEAIAWHLREVIGGDDA--RYSRVVFNEITKNAIRQAFNKPGELNI 159 AD A D D EG I ++ + G++A + SR+ F+ +T+ I++A+ P E++ Sbjct: 104 GADRYIHACDYDIEGTLIGFNALKYGCGEEALRKTSRMKFSTLTREEIQRAYKNPIEVDY 163 Query: 160 DRVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKA 213 +V++ AR +D + G +S L K + LSAGRVQ+ + ++VERE+EI+ Sbjct: 164 GQVDSGAARHILDFIFGVNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEIRD 223 Query: 214 FVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED 273 F P +W + A GE + + K + +E + + + + V + Sbjct: 224 FKPVPYWIIRAEL----GEGIIAE-----SKRGKIFKRELVDSILEKCQGSDAEVKDVRV 274 Query: 274 KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-V 332 + T KP PF TLQ A GF KKT +AQ LY GY +Y RT S L + Sbjct: 275 RDTIRKPPVPFDLGTLQSEAYRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGY 334 Query: 333 NMVRGYISDN--FGKKY-LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQK 389 + ++ N FG P + + +AH AI P+ + ++ D +K Sbjct: 335 EKILKNLAKNPRFGVHIERLRGPLKPHEGKKEDDAHPAIHPTGLLP-----SELSKDEKK 389 Query: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI 449 +Y LI +F++ A + + + G+ + + GW + P + DE+ Sbjct: 390 VYDLIVHRFISVFGEDAILQTMKVELEIGEEEFSFSRKRVSKAGWMESYPYTKMEDEE-- 447 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 P ++ GD+L + ++ + TKPPAR++EASL++ELE+RG+G ST A II+ + DR Y Sbjct: 448 FPEISGGDSLAVRSVSADERETKPPARYNEASLIRELERRGLGTKSTRADIIAKLYDRKY 507 Query: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 + E ++ +GE + D L ++++ + T Q E L+ + + V+D + Sbjct: 508 I--EGKKIRVSPLGENIIDTLTRYCEKIISEELTRQFERELEDIMRGKISKDRVIDEAIT 565 Query: 570 DFTQQLDKAEKDPEEGGM---RPNQMVLTSIDCPTCGRKMGIRTASTGV--FLGCSGYAL 624 + L E++ + G R Q +CP CG K+ I+ + F+GCS Y Sbjct: 566 EVRSILSDIEENLRDIGKELYRAYQDSRVVGECPACGGKLVIKYSPRNRSTFVGCSSYP- 624 Query: 625 PPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCG 684 C+T +L VL L C KCG M SY +R Sbjct: 625 ----DCRTVYSLPRGASVLKSL---------------CEKCGLPMISYGRPRQRACL--- 662 Query: 685 NNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKIL 743 +P C + E E + +C +CGS++ + GR+G+++ C +C+ T + Sbjct: 663 -DPKCGKKKSEVEEV--------VGKCPECGSDLIKRSGRYGEFVGCKGFPKCRFTCSVD 713 Query: 744 RNGE 747 E Sbjct: 714 EVPE 717 >UniRef50_UPI0001C41D8C DNA topoisomerase I TopA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41D8C Length = 741 Score = 495 bits (1274), Expect = e-138, Method: Composition-based stats. Identities = 197/790 (24%), Positives = 345/790 (43%), Gaps = 111/790 (14%) Query: 5 LVIVESPAKAKTINKYL---------------------GSDYVVKSSVGHIRDLPTSGSA 43 ++I E P A+ I K L G V S+VGH+ L ++ S Sbjct: 4 VIISEKPKSAEKIAKALSPNAQKKKYNRKINYWEFEENGKKTTVLSAVGHLYSLTSASSR 63 Query: 44 AKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGK--EKVVSELKQLAE 101 + D T W YEV K ++ +K+L++ Sbjct: 64 DRLGFDLT---------------------------WVPAYEVEKQKYTRDYINAIKKLSK 96 Query: 102 KADHIYLATDLDREGEAIAWHLREVIGGDDARYS--RVVFNEITKNAIRQAFNKPGELNI 159 AD A D D EG I ++ + G++A R+ F+ +TK I +A+N +++I Sbjct: 97 GADKFVHACDYDVEGTLIGYNALKYACGNNAEAKASRMKFSTLTKKDIVEAYNTMRDIDI 156 Query: 160 DRVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKA 213 +V+ AR +D G +S L K + LSAGRVQ+ + ++V+RE+EI++ Sbjct: 157 RQVDHGIARHMLDYYYGMNISSALMKAVRASSSRFISLSAGRVQTPTLSILVDREKEIQS 216 Query: 214 FVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED 273 FVPE +W + A + + H K F ++E+ + + + A V + Sbjct: 217 FVPEPYWMIKAKSDYD------IIADHVEGKIF---DEERAKKIYADCQGADADVTSVKV 267 Query: 274 KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DA 331 + KP PF LQ A T GF K+T + AQ LY GY +Y RT S L + D Sbjct: 268 TESIRKPPIPFNLGGLQSEAHTVFGFSPKRTQVAAQNLYVGGYTSYPRTSSQKLPESLDF 327 Query: 332 VNMVRGYISDNFGKKYLPESPNQYASKENSQEA--HEAIRPSDVNVMAESLKDMEADAQK 389 N+ G D KK++ + P + E + H AI P+ V ++ AD K Sbjct: 328 KNIFAGLAKDPEFKKHIFDLPAKLKPNEGKKTDAAHPAIHPTGVLP-----SNLSADEAK 382 Query: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI 449 +Y LI +F++ +K ++ + + D + + + ++GW K P K E+ Sbjct: 383 IYSLIVYRFISVFSENSKLETMKVNLKVADEKFTFSRKRVSYEGWLKHYPF--KKQENDA 440 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 P +NKGD L + ++ + TKPPAR++EASL+KELEKR +G +T A I++ + DR Y Sbjct: 441 FPPINKGDQLKIHKILVEEKETKPPARYNEASLIKELEKRELGTKATRADIVAKLYDRKY 500 Query: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 + E ++ + +G + D L E ++L + + T + E L+ + + + +L++ Sbjct: 501 I--EGKKIEVKPLGINIIDTLNEYCKDLTSEELTREFERELEGIDTDKYTKEQILENGEK 558 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTS--IDCPTCGRKMGIRTA--STGVFLGCSGYALP 625 + L + ++ ++ G + + + +CG K+ R + + F+GCS + Sbjct: 559 EVKTILAEINQNKKQIGEKLYGAYQETNVVGECSCGGKLIKRYSPRTKNTFVGCSNFP-- 616 Query: 626 PKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGN 685 +CK T +L +L K+ CP CG M S + Sbjct: 617 ---KCKVTYSLPKGANML---------------KKTCPTCGLPMISIKKASGKGRDHVCL 658 Query: 686 NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILR 744 + C + + + +C +CG ++ + GR+G+++ C+ C+ T + Sbjct: 659 DSNCG------KDVSRRQAPEVVGKCPECGKDLLKRSGRYGEFVGCSGFPRCRFTCSVDE 712 Query: 745 NGEVAPPKED 754 + K Sbjct: 713 LNNLGKDKNK 722 >UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK25_9FIRM Length = 765 Score = 495 bits (1274), Expect = e-138, Method: Composition-based stats. Identities = 171/763 (22%), Positives = 285/763 (37%), Gaps = 136/763 (17%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ A+ I + LG S+Y+V ++GH+ L KK Sbjct: 2 KSLVLAEKPSVARDIARVLGCHKNISGAIEGSNYIVTWALGHLVTLADPEEYDKKFKAWD 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIYLA 109 + PKK E V+ K +K + I +A Sbjct: 62 MSYLPMVPKKWE-------------------LVVIKQTSKQYHNVKTQLFRKDVSEIIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQA 167 TD REGE +A + + G R+ + +T AI++ F + D +A ++ Sbjct: 103 TDAGREGELVARWILDKSGC-HKPIRRLWISSVTDKAIKEGFAHLKDGRAYNDLYHAARS 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D +VG + L K LS GRVQ+ + ++ RE++I++F PE+++ + +T+ Sbjct: 162 RAEADWLVGINATRALTCKYNAQLSCGRVQTPTLAMIAHREQQIRSFKPEDYYGLRCTTS 221 Query: 228 TPSGEA------LALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 G + + R NK+ L+ +V + + Sbjct: 222 VTGGSVGTMASIVTWTWQQKKSGSLRSFNKDLITGLDKKLKNQTLTVTDVHTSSKRTPSP 281 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYIS 340 + + LQ+ A+ R GF K+T+ + Q LYE + TY RTDS + D V ++ + Sbjct: 282 GLYDLTELQRDANKRFGFSAKETLNIMQSLYEHHKVLTYPRTDSRYIGTDIVPTIKERLK 341 Query: 341 D-NFG--KKYLPESPNQYAS------KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLY 391 N G KKY+PE + + H AI P++ V E M + +K+Y Sbjct: 342 ACNIGPYKKYIPELLKKPLKTSKAFVDDKKVSDHHAIIPTEEYVQMEH---MSNNERKIY 398 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRK-------- 443 L+ R+F++ +Y+ TTL A A+G++++ GW V Sbjct: 399 DLVVRRFISVLYPAFEYEQTTLKAEAAGETFTAKGKVIKAAGWKAVYADAASSGSSASQY 458 Query: 444 -----------------------GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEA 480 ++ LP ++KGD LT+ TK PARF+EA Sbjct: 459 DAYGDYEDSEDFGEDFQNNDMYLKASEQALPVLHKGDTLTVTRTNITSGKTKAPARFTEA 518 Query: 481 SLVKELEK-------------------RGIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521 +L+ +E G+G +T A II + + + Sbjct: 519 TLLSAMENPVRYMSSDDNKMKKTLGETGGLGTVATRADIIEKLFHSFLLEKKGNEILLTS 578 Query: 522 MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 G+ + + + E +L + TA E L ++A A + V F D + +D Sbjct: 579 KGKQLLELVPE---DLKKPELTASWEMELAKIAKG-AHKEQV---FIKDIESYTKELIQD 631 Query: 582 PEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENE 641 + LT+ CP CG++M L C C Sbjct: 632 IKTSDGTFRHDNLTNTKCPHCGKRMLSVKGKNSRMLVC------QDRECGY--------- 676 Query: 642 VLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCG 684 ET A + RCP C M+ + + VC Sbjct: 677 ---------RETIARTSNARCPNCHKKME-LIKKGDSETFVCS 709 Score = 45.5 bits (106), Expect = 0.010, Method: Composition-based stats. Identities = 14/97 (14%), Positives = 32/97 (32%), Gaps = 14/97 (14%) Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 +I+ + + + +C CG M G+ + + C + EC I R Sbjct: 631 DIKTSDGTFRHDNLTNTKCPHCGKRMLSVKGKNSRMLVCQDRECGYRETIART------- 683 Query: 753 EDPVPLPELPCEKSDAYF-VLRDGAAGVFLAANTFPK 788 C +++ G + F+ + + + Sbjct: 684 ------SNARCPNCHKKMELIKKGDSETFVCSCGYKE 714 >UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris RepID=B8DNH0_DESVM Length = 873 Score = 493 bits (1269), Expect = e-137, Method: Composition-based stats. Identities = 166/767 (21%), Positives = 282/767 (36%), Gaps = 133/767 (17%) Query: 1 MGKALVIVESPAKAKTIN----------KYL-GSDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M K L+I E P+ A+ + +L G D++V +VGH+ + Sbjct: 1 MSKTLIIAEKPSVARELAPLVGATQRRAGFLEGPDHLVSWAVGHLVGIAEPEE------- 53 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIY 107 +D A + P VLP + L++L E+ + Sbjct: 54 -----------QDPAWAGRWTLDQLPMLPPRFRLRVLPETADQFAVLRRLLTDERVTGVI 102 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQ 165 ATD REGE I + ++ R+ +++T+ +R++ + P + A Sbjct: 103 NATDAGREGELIFRRIY-LMAECAKPVRRLWASDMTEEGLRKSLARLLPDAEKRNLGLAS 161 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D +VG S L + +S GRVQ+ + L+ R REI+ FVP++FW V+ Sbjct: 162 FARAEADWLVGMNYSRLFTVRTGGLVSVGRVQTPVLCLLTARRREIEQFVPQDFWTVEGV 221 Query: 226 TTTPSGEALA---------------------------------------LQVTHQNDKPF 246 TP G+ A + + Sbjct: 222 F-TPGGKGRAAQGGVAAPDASPDATADASPAGTQDTPAPASDAPDSFPAVWHRPPELRET 280 Query: 247 RPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMM 306 R ++++ A + V K + +P PF +TLQ+ A+TR G K T+ Sbjct: 281 RVDSEDEASAIANACTGREGVVESVASKAGSQQPPLPFDLTTLQREANTRFGLSAKDTLA 340 Query: 307 MAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGY---ISDNFGKKYLPESPNQYASK---- 358 AQ LYE ITY RTDS +L+++ + + I + + + + K Sbjct: 341 HAQALYETHKLITYPRTDSRHLTKELFAEILNHFRAIHHLYPDETMLAVARIKSGKVKFP 400 Query: 359 ---ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV 415 + H AI P+ + +++Y++I R+F+A A++ ++T+TV Sbjct: 401 CVDDRKVTDHHAIIPT---ARKGDPARLSQPERQIYEMICRRFIAAFCAEARFATSTVTV 457 Query: 416 GAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPA 475 G+ ARG++ + GW V P + ED LP + KG L ++ TK PA Sbjct: 458 KVGEHAFIARGKVFKEKGWLAVEPW--RAAEDTPLPPLRKGARLHTDDIRRVTRQTKAPA 515 Query: 476 RFSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 +++ASL+ +E +RG+G P+T A +I T+ RGYV +R A Sbjct: 516 HYTDASLLAAMETAGKLVEDEELRQAMKERGLGTPATRAQVIETLLQRGYVGRHGKRLIA 575 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 G V + +E ++ + + T E +L + A + + + + + Sbjct: 576 SDRGMQVAEVIEALLPDVASPELTGTWEKALKDMEAGTATYPQFMHGIRESVWNGVHRIK 635 Query: 580 K------DPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKE----- 628 + D CP CG + +R G C+G K Sbjct: 636 RVGGRNLDRLLDTASERYARTPDGLCPLCGGE--VRETPRG--WACTGQPPAKKRGKAAN 691 Query: 629 ------------RCKTTINLVPENEVLNVLEGEDAETNALRAKRRCP 663 + P E RCP Sbjct: 692 GDDSAGQDAARAKRGAKKTGAPNGGPDAAPNSEADGGTPPANGGRCP 738 >UniRef50_D2VSX3 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2VSX3_NAEGR Length = 1015 Score = 491 bits (1265), Expect = e-137, Method: Composition-based stats. Identities = 171/814 (21%), Positives = 304/814 (37%), Gaps = 79/814 (9%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLP--TSGSAAKKSADSTSTKTA 56 K L + E P AK I L + KS I + +G S S Sbjct: 23 KVLCVAEKPEAAKQIATILSAGKFQRREGKSKFNKIFEFEYRMNGVVVTMSVTSVLGHLM 82 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKE-KVVSELKQLAEKADHIYLATDLDRE 115 + + + + + + +P K ++ L+Q A A + L D DRE Sbjct: 83 ELGFDPKLKSWTSCDPITLMDPATPVFRNVPEKNLEIQQNLEQEARYATKLLLWLDCDRE 142 Query: 116 GEAIAWHLREVIGG-------DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQAR 168 GE IA+ + EV ++ R F+E T AI +A N+ A R Sbjct: 143 GENIAFEVIEVCKKVNRSLSIENDSILRARFSEFTAAAINRAIRNLERPNVLDSMAVDTR 202 Query: 169 RFMDRVVGYMVSPLLWKKIARG--------LSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 + +D +G + ++ + +S G Q + VV+R+ IK F E FW Sbjct: 203 QELDLRIGASFTRFQSLRLKKKFQGITADYISYGPCQFPTLGFVVKRDLIIKNFESESFW 262 Query: 221 EVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 ++ T GE Q + + F + +E R V+ E K Sbjct: 263 TLNC--THDMGEEGKAQFLWKRGRLFDQLTCLVIYELC--VEAQRARVVNVEKKRRYKYR 318 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS 340 P T LQ+ AS +L G +TM +A+ LY G+I+Y RT++ N +Q + ++ ++ Sbjct: 319 PDPLNTIELQKLASQKLKMGSHETMKVAESLYNKGFISYPRTETNNYNQFQDDDLKRLVN 378 Query: 341 DN--------FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQ 392 ++ + L + S + +AH I P + ++ Q LY+ Sbjct: 379 EHTSNPTWGGYASDLLNGGYQKPPSGKQDDKAHPPIHP-----LKGDCNSNDSKEQALYE 433 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPA 452 LI R F+AC A T + + + G ++ + ++ R D + +P Sbjct: 434 LIARHFLACCSKDAVGAETKVIISIANEEFTCSGLMVEQKNFLEIWKYDRWSD--KSIPV 491 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 N G L T+PP SE+ L+ ++ GIG +T A I TIQ+RGYV Sbjct: 492 FNAGQEFIPTSLLMDHGETRPPPHLSESDLISAMDSNGIGTDATVAQHIKTIQERGYVIK 551 Query: 513 ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 + RF A +G + + EL + ++ME + ++ E +AV+ S + Sbjct: 552 KGNRFEATNLGMALLQGYDLIGYELSTPNLRSKMEKDMLSISKGEQSKEAVIHQSLSMYK 611 Query: 573 QQLDKA-----------EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG 621 + ++ G ++++ +C M ++ FL C Sbjct: 612 HVYIQICKSAYLLDKAVQQHFPTLGEGQSRVLGRGFSLCSCKNPMDLKEQDGNNFLHCKN 671 Query: 622 ----YALPPKERCKTTINLVP--ENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLID 675 Y LP K ++ ++ P ++LN++ T + + CP C + + Sbjct: 672 CSDSYPLPSKSEYESIEDVCPICNFQILNII------TQKNTSYKLCPHCFNNPPE-IEN 724 Query: 676 PKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRF--GKYMACTN 733 C G + D + +C+KC + + ++ + Y+ C Sbjct: 725 SNESFANGFKCFNCTFT----GCKYSRKKDAVVRKCQKCSNNLVVRQRKNDTSLYIGCKG 780 Query: 734 -EECKNTRKILRNGEVAPPKEDPVPLPELPCEKS 766 CK+ + ++ E A L C + Sbjct: 781 FPNCKSAVWLPKSIEKA-------DLTTEKCNRC 807 >UniRef50_Q4A5N2 DNA topoisomerase n=2 Tax=Mycoplasma RepID=Q4A5N2_MYCS5 Length = 625 Score = 491 bits (1264), Expect = e-137, Method: Composition-based stats. Identities = 213/667 (31%), Positives = 322/667 (48%), Gaps = 65/667 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP K KTI KYLG+DY V S VGHI + TSG Sbjct: 1 MNK-LVIVESPNKVKTIQKYLGNDYNVISCVGHIYKMKTSGPFG---------------- 43 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +G+D + NWE YE K+KV ELK +KA +Y+ATD DREGE+I Sbjct: 44 ----------LGID-FENWEPLYEFDSTKKKVGKELKDSLKKAQMVYIATDPDREGESIG 92 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +L + +D Y RV +NEITK+AI +AF+ P +LN +NAQ++RR +DR++G+ +S Sbjct: 93 ENLVSYLKLND-NYKRVTYNEITKDAILKAFDNPHDLNWALINAQKSRRMLDRIIGFRLS 151 Query: 181 PLLWKKIARGLS---AGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 LL K+ S AGRVQS+A++LV++REREI AFVP ++W+++A A Sbjct: 152 KLLQSKLQNAPSNASAGRVQSIALKLVIDREREILAFVPTKYWKLNA-FLLNENSLKAQY 210 Query: 238 VTHQNDKPFRPVNKE----QTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAA 293 +N + E + + L+ + V + +K PF Q A Sbjct: 211 FNEENSSGQKEWIFESQIKEVKEFFEKLKDKKVKVTKINVTEKKNKALVPFK----QAAI 266 Query: 294 STRLGFGVKKTMMMAQRLYEA----GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 R + T Q+LYE G I+Y RTDST LSQ VN + +I +G ++ Sbjct: 267 YKRSPYSAAMTQSTLQKLYEGYGDGGLISYPRTDSTRLSQTFVNQAKKFIESKYGSDFVS 326 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDM----EADAQKLYQLIWRQFVACQMTP 405 + Q+AHEAIRP+D+N++ E+L+ + ++ LY+LI+ + + P Sbjct: 327 SEVKGFT---GDQDAHEAIRPTDLNLLPENLEKLYPTISSNEVNLYKLIYEHTLKALIKP 383 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELT 465 S + K + F G+ V K ++D P +T+ Sbjct: 384 PVIKSKQYIYQVDKYLFKNSFATVTFQGYYCVSAPEEKQEKD---PNFEINQEVTVNNFA 440 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGE 524 TKP R+++ SL++ L+ +GRPST+AS + I+DR YV V ++ G Sbjct: 441 FEDLETKPTPRYNDGSLIEALDDIKVGRPSTFASTVKIIKDRQYVEVLDSNAIKPTDFGM 500 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 IV D+L NF E++N +TA++E LD ++ ++ E V+ F++ F + D+ E+ Sbjct: 501 IVLDKLVNNFPEIINEKYTAEVEGQLDLISENKLEKNQVMHDFYTKFNELYDQVASTMEK 560 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTG-VFLGCSGYALPPKERCKTTINLVPENEVL 643 + N DCP C K+ IR F+GC + C T + + Sbjct: 561 TRLEDN---FLDEDCPDCSGKLLIRLNRKKQKFIGCKSFP-----NCTYTRSYEDPDAKK 612 Query: 644 NVLEGED 650 Sbjct: 613 RYYRNYK 619 >UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NY48_9GAMM Length = 776 Score = 491 bits (1263), Expect = e-137, Method: Composition-based stats. Identities = 169/743 (22%), Positives = 283/743 (38%), Gaps = 75/743 (10%) Query: 3 KALVIVESPAKAKTINKYLG---SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKP 59 +VI E P+ A+ I + LG + Y + ++ GHI + + Sbjct: 2 TTVVIAEKPSMARAIREGLGPQANRYEITNAFGHILEQAEPDAY-----------LPGDV 50 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 K +G + RM P E + ++++ L + AD + A D DREG+ + Sbjct: 51 PKTAKGKKIWRMQDLPILPAEWKKFPKRDAKDQLAKIGALLKSADTVINAGDPDREGQLL 110 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQQARRFMDRVVGY 177 + E + RV + +R+AF E +A +AR D VVG Sbjct: 111 IDEILEHFH-YRGKVLRVWLKALDAENVRKAFAALESNEKYRPLKDAAEARSQSDWVVGM 169 Query: 178 MVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 ++ + K S GRVQ+ + +VV R+ EI+ FVP +++EV A G LA Sbjct: 170 NLTRAVTVKSGDLFSIGRVQTPTLAIVVRRDLEIENFVPRDYFEVFAQCRHTQGAFLAKW 229 Query: 238 VTHQ-----NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 D+ R ++K +A + A V E K P+ S LQ+ Sbjct: 230 EPSSTDGPGFDEEGRLIDKRLAEAVAQKAKGA-GKVARFEAKEQKQSAPLPYSLSALQKV 288 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD----NFGKKYL 348 AS+R G ++ + Q LYE +Y RTD L ++ + + + + L Sbjct: 289 ASSRFGMSAQQVLDTCQSLYEKKITSYPRTDCRYLPEEQLVDAPRILGKLPIPDGIRPLL 348 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKY 408 A AH AI P+ E + + KLY LIWR +VA + +Y Sbjct: 349 NPRQKHVAWNNAKITAHNAIVPTG-----EPARGLSDAEAKLYDLIWRSYVALFLPDYRY 403 Query: 409 DSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED------RILPAVNKGDALTLV 462 + + T+ G KA GR GW K+ A D++ LP + GD + Sbjct: 404 RALSATIALGGESWKATGRQDIDLGWKKLFGAQALEDDEDADGGKAPLPVMQTGDPVQGD 463 Query: 463 ELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYASIISTIQ 505 TKPPARF++ SL+ + E G+G +T AS++ T+ Sbjct: 464 GGKVEARQTKPPARFTDGSLIDAMSNIHKFVTDPQAKAKLKETSGLGTEATRASVLETLL 523 Query: 506 DRGYVRVENRRFYAEKMGEIVTDRLEE-NFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 R Y++ + ++ + G + LE+ + TA+ E+ L VA + + Sbjct: 524 QREYLQKKGKQLISTPKGRALIAYLEKQRLGSFADPVTTARWEDVLGMVAEGKVPMQKFT 583 Query: 565 DHFFSDFTQQLDKAEK-DPEEGGMRPNQMVLTSIDCPTCGRKMGIRT-----ASTGVFLG 618 + + ++ + GG +Q L + CP CG +R F Sbjct: 584 AAVTQEVAKAIEVLKSGSAMAGGGSSSQQPLRAQPCPICGGDAVVRRLQSKKNRKVFFWS 643 Query: 619 CSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKC-GTAMDSYLIDPK 677 CS + L+ ++ + + ++ CP C GTA + Sbjct: 644 CSN---------RDAHPLLQDDNGKPDKPFAERKEDSGPPGPECPHCAGTATRTKTTSTG 694 Query: 678 RKLHVCGNNPTCDGYEIEEGEFR 700 + + C P+C + E Sbjct: 695 KTYYRC---PSCQAAFWPDREDP 714 >UniRef50_Q13472 DNA topoisomerase 3-alpha n=31 Tax=Eumetazoa RepID=TOP3A_HUMAN Length = 1001 Score = 489 bits (1259), Expect = e-136, Method: Composition-based stats. Identities = 184/842 (21%), Positives = 299/842 (35%), Gaps = 95/842 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVK----SSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 K L + E AK I L + + + S I + + TS + Sbjct: 35 KVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEFDYHLYGQNVTMVMTSV-SGHL 93 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEV--LPGKEKVVSELKQLAEKADHIYLATDLDREG 116 D + +P +EA E + L++ + + + TD DREG Sbjct: 94 LAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREG 153 Query: 117 EAIAWHLREVIG--GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E I + + V + + R F+EIT +A+R A E + +A R+ +D Sbjct: 154 ENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLR 213 Query: 175 VGYMVSPLLWKKIAR---------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G + ++ R +S G Q + VVER + I+AFVPE F + + Sbjct: 214 IGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVT 273 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLL-EKARYSVLEREDKPTTSKPGAPF 284 G + N K R N L E +V+E KP + Sbjct: 274 HDHKDG------IVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQAL 327 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDST------NLSQDAVNMVRGY 338 T L++ AS +L K+TM +A++LY GYI+Y RT++ NL+ Sbjct: 328 DTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDP 387 Query: 339 ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 F + L + S +AH I P+ +++ D Q+LY+ I R F Sbjct: 388 RWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYT------NNLQGDEQRLYEFIVRHF 441 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 +AC A+ TT+ + R A G ++ + V P D +ILP +G Sbjct: 442 LACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSD--KILPVYEQGSH 499 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-NRRF 517 + T PP +EA L+ +EK GIG +T+A I TI+ R YV + ++RF Sbjct: 500 FQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRF 559 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD----FTQ 573 +G + + + E+ D A++E L + + + + VL F + Sbjct: 560 LPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIE 619 Query: 574 QLDKAEKDPEEGGMRPNQ-------------MVLTSIDCPTCGRKMGIRTASTGVFL-GC 619 + KA+K E M CP C + M ++T G F C Sbjct: 620 AVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSC 679 Query: 620 SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG-TAMDSYLIDPKR 678 G+ C++ + L D+ A R CP C + + KR Sbjct: 680 MGFP-----ECRSAVWL------------PDSVLEASRDSSVCPVCQPHPVYRLKLKFKR 722 Query: 679 ---------KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYM 729 + C CD E + R G P + + + R Sbjct: 723 GSLPPTMPLEFVCCIG--GCDDTLREILDLRFSGGP-PRASQPSGRLQANQSLNRMDNSQ 779 Query: 730 ACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL----RDG--AAGVFLAA 783 + + T + PP + C VL ++G F Sbjct: 780 HPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCN-CGQEAVLLTVRKEGPNRGRQFFKC 838 Query: 784 NT 785 N Sbjct: 839 NG 840 Score = 47.0 bits (110), Expect = 0.003, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 19/55 (34%), Gaps = 3/55 (5%) Query: 757 PLPELPCEKSDAYFVLRDGAAGVFL-AANTFPKSRET--RAPLVEELYRFRDRLP 808 P P C + + VL+ G F + FP+ R V E R P Sbjct: 652 PEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCP 706 >UniRef50_O95985 DNA topoisomerase 3-beta-1 n=72 Tax=Eukaryota RepID=TOP3B_HUMAN Length = 862 Score = 487 bits (1254), Expect = e-136, Method: Composition-based stats. Identities = 177/803 (22%), Positives = 295/803 (36%), Gaps = 69/803 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVK------SSVGHIRDLPTSGSAAKKSADSTSTK 54 M L++ E P+ A++I K L + + H +G + S Sbjct: 1 MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGH 60 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPG---KEKVVSELKQLAEKADHIYLATD 111 D G VDP + K +V L+ D+I L D Sbjct: 61 VMTL---DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLD 117 Query: 112 LDREGEAIAWHLREVI-------GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNA 164 D+EGE I + + + + G + R F+ IT I A GE + + + Sbjct: 118 CDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALS 177 Query: 165 QQARRFMDRVVGYMVSPLLWKKIARG--------LSAGRVQSVAVRLVVEREREIKAFVP 216 AR+ +D +G + K +S G Q+ + VER +I++F P Sbjct: 178 VDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKP 237 Query: 217 EEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLE-KARYSVLEREDKP 275 E +W + A T +L L R ++E Q +++ + + V K Sbjct: 238 ETYWVLQAKVNTDKDRSLLLDWDR-----VRVFDREIAQMFLNMTKLEKEAQVEATSRKE 292 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VN 333 + T + + AS+ LG G + M A+RLY GYI+Y RT++T+ ++ Sbjct: 293 KAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKG 352 Query: 334 MVRGYISDNFG----KKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQK 389 +R + + K+ L E N+ K + H I P AE + DA + Sbjct: 353 SLRQQANHPYWADTVKRLLAEGINR-PRKGHDAGDHPPITPMKSATEAE----LGGDAWR 407 Query: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI 449 LY+ I R F+A KY +T++ G G+ + G+T+VMP E+ Sbjct: 408 LYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEES- 466 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 LP +GDA + E+ + T PP +EA L+ +EK GIG ++ I+ I R Y Sbjct: 467 LPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNY 526 Query: 510 VRVE-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH-- 566 V VE RR +G ++ + EL+ + +E L+ +A +A+++ VL H Sbjct: 527 VTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTL 586 Query: 567 --FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGR--KMGIRTASTGVFLGCSG- 621 F F +D E + + + T CG+ + + L CS Sbjct: 587 DVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHC 646 Query: 622 ---YALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR 678 Y LP K L + ++ ++ CP C + Sbjct: 647 DETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRG--KSYPLCPYCYNHPPFRDMKKGM 704 Query: 679 KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKN 738 + C +P+C G I +C +C S + + G +C Sbjct: 705 GCNECT-HPSCQHSLSMLG----------IGQCVECESGVLVLDPTSGPKWKVACNKCNV 753 Query: 739 TRKILRNGEVAPPKEDPVPLPEL 761 N D + E Sbjct: 754 VAHCFENAHRVRVSADTCSVCEA 776 >UniRef50_A1U7T2 DNA topoisomerase I n=2 Tax=Marinobacter RepID=A1U7T2_MARAV Length = 729 Score = 487 bits (1253), Expect = e-136, Method: Composition-based stats. Identities = 224/750 (29%), Positives = 330/750 (44%), Gaps = 80/750 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 MG+ LVIVESPAK+K I LGS+Y V +SVGH+RDLP Sbjct: 1 MGQILVIVESPAKSKKIQTILGSNYRVAASVGHMRDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD + Y V GK +VVS LK+LA +D + LATD DREGEAIA Sbjct: 39 -------PRDLGVD-LETLKPTYVVSEGKSQVVSNLKRLAGMSDEVILATDPDREGEAIA 90 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+ + D RV + EIT++AI +A PG +++ V AQ++RR +DR++GY VS Sbjct: 91 WHLKVALRLPDD-VKRVSYQEITRDAIMKAMANPGRIDMKLVAAQESRRVLDRLIGYQVS 149 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P L K LSAGRVQSVAV+ VV+REREI+AF P + + +L +T Sbjct: 150 PALSSKANLSLSAGRVQSVAVKFVVDREREIQAFQPRGYNVCTLRLAGHPNVSASLDMTP 209 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 K R Q R +++ E KP KP + F T LQ A G Sbjct: 210 FVPKDERLWKASDAQPFAG---PQRVKLVKVEKKPNAVKPKSAFTTVDLQGVAGKIFGLS 266 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 K+ M AQ L+E G ITY RTDS NLS + + ++ Y+S + + ++ SK + Sbjct: 267 AKEVMAAAQTLFEQGLITYHRTDSPNLSDEGIAKIQSYLSGQ--GVPIADQVVRHKSKGD 324 Query: 361 SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG-- 418 +QEAHEAIRP+DV+ D + +Y LI + + M T + Sbjct: 325 AQEAHEAIRPTDVSAATAGQTDT---EKNVYSLIRERAMLSVMPNGIDAVTQYVFQSERR 381 Query: 419 ---------DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 + A+G +++ GW R +D LP + +G + + Q Sbjct: 382 VPGLSGRPVNPMYMAKGSVVQEKGWRAYAKLERIKSKDTPLPLLEQG-RIYDGSVAAVQK 440 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR-----FYAEKMGE 524 T+PP+R++E +L+K LE +GIGRPSTYA I+ I++R Y+ + F K+G Sbjct: 441 TTEPPSRYNEQTLIKALEAKGIGRPSTYAQIMENIKNRSYIEPKPGSGKSPAFVPGKLGY 500 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 + D L M+Y +T +E SLD+VA + ++ T + + Sbjct: 501 YIVDALSRF--SFMSYTYTRAVEASLDKVARGSMSYVGLVRPVSDQLTSDIAE------- 551 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIR-TASTGVFLGCSGYALPPKERCKTTINLVPENEVL 643 + + CP C + + + +G G S I+ + Sbjct: 552 --RLEAESLALKGRCPGCDQPIIQKHRKGSGRGKGRS----QGSRAFWVHIDDAHAAACV 605 Query: 644 NVLEGEDAET--NALRAKRRCPKCGTAMDSYLIDPK-RKLHVC----GNNPTCDG-YEIE 695 L E CP+C + R + G+ C + + Sbjct: 606 QYLNDEHDAPVLPPPEVTSPCPQCQATLIRRYSKTGSRSPYWAHAERGDGDACGVKFFPD 665 Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRF 725 + P +C CG M + Sbjct: 666 VDGQPVIPEPIPETKCVDCGGIMKKRKNSK 695 Score = 50.5 bits (119), Expect = 3e-04, Method: Composition-based stats. Identities = 27/146 (18%), Positives = 44/146 (30%), Gaps = 24/146 (16%) Query: 649 EDAETNALRAKRRCPKC----------GTAMDSYLIDPKRKLHVCGNNP---TCDGYEIE 695 E E +L K RCP C G+ R V ++ C Y + Sbjct: 551 ERLEAESLALKGRCPGCDQPIIQKHRKGSGRGKGRSQGSRAFWVHIDDAHAAACVQYLND 610 Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFG---KYMACT----NEECKNTRKILRNGEV 748 E + + C +C + + + + G Y A + C +G+ Sbjct: 611 EHDAPVLPPPEVTSPCPQCQATLIRRYSKTGSRSPYWAHAERGDGDACGVKFFPDVDGQP 670 Query: 749 APPKEDPVPLPELPCEKSDAYFVLRD 774 P+ P+PE C R Sbjct: 671 VIPE----PIPETKCVDCGGIMKKRK 692 >UniRef50_B5JHP8 DNA topoisomerase n=2 Tax=Bacteria RepID=B5JHP8_9BACT Length = 781 Score = 487 bits (1253), Expect = e-136, Method: Composition-based stats. Identities = 173/807 (21%), Positives = 298/807 (36%), Gaps = 124/807 (15%) Query: 4 ALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 +V+ E P+ A+ I K+L G+ + V + GH+ +L + Sbjct: 2 KVVLAEKPSVARDIAKHLKAGQRHDGYLEGNGWAVTWAFGHLVELKEPEEYRPEWKSWKV 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P +E G +K + +K+L +A+ I ATD Sbjct: 62 SLLPIVP-----------------DQFELRARGDDGAKKQLETVKKLFGEAEEIICATDA 104 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 REGE I ++ E G + R+ + +T AI + F K E A + R Sbjct: 105 GREGELIFRYILEWSGCEAKPVKRLWISSLTGAAISKGFAKLREGKDFDTLHYAARCRSE 164 Query: 171 MDRVVGYMVSPLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D +VG + + + LS GRVQ+ + ++V R+ EI+ F E+FWE+ Sbjct: 165 ADWIVGMNATRYFTVEYGKRNLLLSLGRVQTPILAMIVGRDMEIENFKSEDFWELHT--- 221 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 E + H K + +E+ +A ++ V + + K + P F + Sbjct: 222 ----ECRDTKFRHTGGKIQK---EEEAKALFEKVDGQPLVVSDVQQKNENTNPPLLFDLT 274 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ-------DAVNMVRGYIS 340 LQ+ + R GF +T+ +AQ LYE ITY RTDS LS + ++ Sbjct: 275 ELQREMNRRYGFTADQTLRIAQNLYEQKRITYPRTDSRYLSTDLQPTIGPLLERLKAIKE 334 Query: 341 DNFGKKYLPE-SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFV 399 L + S + ++ H AI P+D + +++ AD +++Y I + + Sbjct: 335 KEIAPLELDKLSFGKRIVDDSKVSDHHAIIPTD-----DLPRNLNADEERVYDAILVRLI 389 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPAL------------RKGDED 447 A TT+ A + +ARG +L GW + P L + E Sbjct: 390 AVFYPACVKAVTTVEAKASEETFRARGTVLLEAGWQALYPQLFAIASKKKGAKGKAAPEP 449 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGI 491 +P G++ + + T PP RF+EA+L+ +E +G+ Sbjct: 450 AAMPHFQVGES-NPHRPSIEKFKTNPPKRFTEATLLSLMETAGKIVEDEELKEALKDKGV 508 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G P+T ASII + R YV + + + G + +++ L + + T E L Sbjct: 509 GTPATRASIIEVLIQRKYVERKKKNLISTYSGRHLISLIQD--ERLKSPELTGDWEFRLK 566 Query: 552 QVANHEAEWKAVLDHFFSDFTQQL-DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRT 610 +V E + KA + + L + AEK + + P CP C + Sbjct: 567 KVERGEQDPKAFMSDVVEYTKEILANDAEKTVDLKNLGP---------CPKCSAPVM--R 615 Query: 611 ASTGVFLGCSGYALPPKERCK---TTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGT 667 +TG GC+ + K K I P + G E + K G Sbjct: 616 GNTG--YGCTRWREGCKFVVKDGVFGITFQPPLMRELLFNGRSLEPQPISDK------GK 667 Query: 668 AMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK 727 + +++ K+ +E + +C C S + G G Sbjct: 668 KLLGFVVLGKQG--------ALKYELVESSQE--THGQAKFGDCPLCKSAIVE--GEKG- 714 Query: 728 YMACTNEECKNTRKILRNGEVAPPKED 754 C N + I + P E+ Sbjct: 715 -YGCCNWKNGCKFIIWKQVAQRPISEE 740 >UniRef50_B2V7T0 DNA topoisomerase I n=5 Tax=Aquificales RepID=B2V7T0_SULSY Length = 683 Score = 486 bits (1251), Expect = e-135, Method: Composition-based stats. Identities = 215/581 (37%), Positives = 313/581 (53%), Gaps = 47/581 (8%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K +VIVESP KAK I+ +LG D++VK++VGH +DLP Sbjct: 4 KKIVIVESPKKAKEISHFLGKDFIVKATVGHFKDLPE----------------------- 40 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGK-EKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 N MGVD + +E + + +K++SE+K+LAEK + +ATD DREG AI + Sbjct: 41 ------NEMGVD-LNTYEPKFVIKSQNHKKILSEIKKLAEK-SEVIIATDPDREGYAIGF 92 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKP---GELNIDRVNAQQARRFMDRVVGYM 178 + E + R F+EITK I++ + N NA RR DR+VGY Sbjct: 93 FMYEELKKKAKEVKRAEFHEITKEHIKEKIKNAVPFEKTNFGLFNAFLGRRVGDRIVGYT 152 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-EALALQ 237 +SP+ ++I S GRVQS AVRL+VERE EI+ F P ++ + A S L Sbjct: 153 LSPIASREIGGRFSVGRVQSPAVRLIVEREIEIQNFKPTPYYVLSAVLRATSHVSPLTFT 212 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 ++N K NKE+ + + ++ + ++ + E K P PF TSTLQQ AST Sbjct: 213 AIYENPK---IENKEEAEKIYADIKDEKIATIKKVEKKQVKQSPKPPFTTSTLQQTASTV 269 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 F +KTMM+AQ L+E+G ITY RTDS +S+ A++ +R I+ FGK YLPE Y Sbjct: 270 YRFAPEKTMMLAQDLFESGLITYHRTDSVRISEKAIDGIRNLINKEFGKDYLPEKIRVYK 329 Query: 357 SKENSQEAHEAIRPSDVNVMAES-----LKDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 SK +AHEAIR + + E K + D KL +LI+ + VA QM A ++ T Sbjct: 330 SKNTQADAHEAIRITHFVNLEEQKKLIKEKGLSEDHFKLLKLIYERTVASQMADAIFERT 389 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMP--ALRKGDEDRILPAVNKGDALTLVELTPAQH 469 + V + KA G IL+F G+ V +E++ LP + D LTL ++ + Sbjct: 390 SAAVDIKGYTFKASGSILKFKGYKAVYDLEEEEDKEENQKLPDLKNKDVLTLEKINLEEK 449 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FTKPPAR++E LVK+LE+ GIGRPSTYA+II TI++RGYV EN + + + Sbjct: 450 FTKPPARYTEGGLVKKLEELGIGRPSTYATIIKTIKERGYVVKENGSLRPTENAFHLIEY 509 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 L + +++Y FT +ME+ LD+V ++ +WK + Sbjct: 510 LNTRYNWVIDYSFTKKMEDFLDKVEENKKDWKEFVKQLHEK 550 >UniRef50_UPI00016C444E DNA topoisomerase I n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C444E Length = 985 Score = 486 bits (1251), Expect = e-135, Method: Composition-based stats. Identities = 213/601 (35%), Positives = 306/601 (50%), Gaps = 43/601 (7%) Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 TP + + ++ + ++ A V+ L + V + E K +P PF Sbjct: 336 IPTPPKDTFLANLAKWDNAEPKLASEADADAVVAALAGVPFVVSKAEKKTRQDRPLPPFT 395 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVR 336 TSTLQQ A+ R+ F +TM AQ+LYE ITYMRTDST +S DA+ VR Sbjct: 396 TSTLQQQANARMRFSASRTMQTAQKLYEGVELTGMGQVALITYMRTDSTRVSNDALTAVR 455 Query: 337 GYISDN--FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD--MEADAQKLYQ 392 YI G +YLP PN Y S +++QE HEA+RP+DV + + + + D +LY Sbjct: 456 AYIQGTTFLGPRYLPAQPNAYKSGKSAQEGHEAVRPTDVKITPKDAEKAGLGGDQLRLYT 515 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPA 452 LIW++FVA Q TPA+ D TT + AG +A GR++ FDG+ KV+P + + +E LP Sbjct: 516 LIWQRFVASQCTPAEMDVTTYEITAGRGLFRASGRVITFDGYRKVLPPVGRQEEPE-LPP 574 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 V + D L ++L +QHFT+PP RF+E SLVK LEK GIGRPSTYASIISTIQ RGYV Sbjct: 575 VKEKDVLNRLDLFESQHFTQPPPRFNEGSLVKALEKEGIGRPSTYASIISTIQKRGYVTQ 634 Query: 513 ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 + RF+A ++G++VTD L ++F +M+ FT++ E LD++ + ++ VLD F+ F+ Sbjct: 635 DRGRFFATEIGKVVTDLLVKHFPNIMDTQFTSKFETELDEIETGKFRYREVLDEFWDSFS 694 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAST--GVFLGCSGYALPPKERC 630 + L A+ + P LT CP CGR M R ++T G F GC+GY+ P C Sbjct: 695 KTLKSADAEM------PVARELTGEKCPKCGRDMQKRYSTTTGGFFEGCTGYSADPP--C 746 Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCD 690 K + GE CP CG M + + C P C Sbjct: 747 KY----------IKPRPGEAEREGPTVTDIPCPACGKHMVR-KVGRFGVFYTCEGAPDCP 795 Query: 691 GYEIEEGE-FRIKGYDGPIVECEKC-GSEMHLKMGRFG-KYMACTNEECKNTRKILRNGE 747 E E R +C KC + LK + G KY+ C + +CK +G Sbjct: 796 TTMNENAEGVRTVTALPTKHKCPKCEKHNLLLKESKAGKKYVQCPDAKCKFISDADADGA 855 Query: 748 VAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRL 807 P + V CEK + V++ G FL+ + +PK R ++ E + +D L Sbjct: 856 PVKPADTGVA-----CEKCGSPMVIKVAWRGPFLSCSGYPKCRNAKSINAELREKLKDIL 910 Query: 808 P 808 P Sbjct: 911 P 911 Score = 223 bits (569), Expect = 2e-56, Method: Composition-based stats. Identities = 112/251 (44%), Positives = 150/251 (59%), Gaps = 12/251 (4%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LV+VESPAKAKTINKYLG ++ V +S GH+RDL T KK D A K Sbjct: 52 LVVVESPAKAKTINKYLGPNFRVLASYGHVRDLDTK---KKKGEDIAGIDIANGWKL--- 105 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 R VD E + ++++ E+ + A +A+ +YLA+D DREGE+IAWH+ Sbjct: 106 -----RYTVDDGSKSEGGRKRFRTAKEILGEIGREASRANKVYLASDPDREGESIAWHIA 160 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 + + DA R+ FNEITKNA+ A ++N RV+AQ+ARR MDRVVG+ +S LL Sbjct: 161 DELKLPDATTYRIRFNEITKNAVNAALAGAEKINDLRVSAQEARRAMDRVVGFPLSNLLG 220 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDK 244 KK+A LSAGRVQSVAV+L+V+REREI+AF EE+W++ A P +A A K Sbjct: 221 KKVASRLSAGRVQSVAVKLIVDREREIEAFKTEEYWKITALLAAPGVKA-AWTPDPAKSK 279 Query: 245 PFRPVNKEQTQ 255 F E + Sbjct: 280 IFAKKKTEAAK 290 Score = 57.4 bits (137), Expect = 2e-06, Method: Composition-based stats. Identities = 23/106 (21%), Positives = 37/106 (34%), Gaps = 15/106 (14%) Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVL----- 643 P + T + C CG M I+ A G FL CSGY +C+ ++ E Sbjct: 856 PVKPADTGVACEKCGSPMVIKVAWRGPFLSCSGYP-----KCRNAKSINAELREKLKDIL 910 Query: 644 ----NVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK-RKLHVCG 684 +E ++ ++ CP+CG + C Sbjct: 911 PPPQEKVEKKEDPALSVEVTETCPECGAPLKLRKSRFGPGYYLGCS 956 >UniRef50_D0LL88 DNA topoisomerase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LL88_HALO1 Length = 867 Score = 485 bits (1248), Expect = e-135, Method: Composition-based stats. Identities = 161/698 (23%), Positives = 259/698 (37%), Gaps = 106/698 (15%) Query: 2 GKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADS 50 L+I E P+ A+ I + +G+ Y V +GH+ +L K Sbjct: 3 ATTLIIAEKPSMARDIARVVGARSKREGYLEGGGYWVSWCIGHLAELCEPHEYDAKWKSW 62 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLAT 110 + + P + + V P + AH VL A + I A Sbjct: 63 SPSLLPILP---------DELRVRPSRSGAAHLRVL--------HRLMRAREVGTIVNAC 105 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQAR 168 D REGE I H+ + R+ + +T AIR+ + +PG D +A +AR Sbjct: 106 DAGREGELIFRHV-HALSNTRKPVRRLWISSLTGEAIRRGMSALRPGAEFDDLADAARAR 164 Query: 169 RFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 D +VG + L + G +S GRVQ+ + L+V REREI++F + FW+V Sbjct: 165 ADADWLVGMNATRALTGLVRSGGTRGLLMSVGRVQTPTLALIVRREREIESFESKPFWQV 224 Query: 223 DASTTTPSGEALALQVTHQNDKPF--------------------------------RPVN 250 A+ P + + Q + R Sbjct: 225 LATFAVPGEAGASYEGIWQRPREAGDDAGDAQRDNKGDAQRDNKGDGDTNTARDRSRVPT 284 Query: 251 KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQR 310 ++Q A + ++ + K T +P F + LQ+ A+ R K+T+ +AQ Sbjct: 285 RQQADAIADAVRGRAGTITQLTRKSTRERPPLLFDLTNLQKLANRRFRMSAKRTLELAQA 344 Query: 311 LYE-AGYITYMRTDSTNLSQDAVNMVRGYISDNFGK----------KYLPESPNQYASKE 359 LYE ITY RTD+ L+ D + + G+ + N+ Sbjct: 345 LYETHKLITYPRTDARYLTDDLAPTLPELVRALAGEYPGLRDTALAGAAHAAGNRRIFDN 404 Query: 360 NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD 419 H AI P+ A S + AD ++LY LI R+F+A A YD T + Sbjct: 405 AQVGDHHAIIPT---AKAPSPGRLSADERRLYDLIARRFLASLFPDAVYDQTKIVTTVAG 461 Query: 420 FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSE 479 R+ GW + P + LP + + + + + T+PP R+SE Sbjct: 462 HCFATERRVCAEPGWQQAEPPPPAKRNEPPLPRLRQDMEVDTAAIEVREGKTQPPKRYSE 521 Query: 480 ASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMG 523 ASL+ +E G+G P+T A+II T+ R Y+ + R + G Sbjct: 522 ASLLGAMEHAGRSLDDPGLRRVMRDAGLGTPATRAAIIETLLKRSYIERQGRELVPTEQG 581 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPE 583 + + +L++ + TA E LD +A A +D + +D + Sbjct: 582 RALIASVP--IEDLLSAELTADWEQKLDAIARGRASKARFMDEIHGYVRRIVDALAQATP 639 Query: 584 EGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG 621 P VL CP C G+ T F SG Sbjct: 640 PSLPSPTDEVLGL--CPVCN---GVVTEGFKTFQCASG 672 >UniRef50_O51768 DNA topoisomerase 1 n=22 Tax=Borrelia RepID=TOP1_BORBU Length = 848 Score = 485 bits (1248), Expect = e-135, Method: Composition-based stats. Identities = 213/679 (31%), Positives = 351/679 (51%), Gaps = 41/679 (6%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+IVESP KAKTI K+L ++V++ +GH+ DLP + AK+ K+ Sbjct: 4 KKLIIVESPTKAKTIKKFLDESFLVEACIGHVVDLPNN---------------AKEIPKE 48 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + + +D + + Y + K+ +VS+LK+L + + IYLATD DREGE IA+H Sbjct: 49 YKKYEWANISIDYNNGFNPIYIIPSNKKPIVSKLKKLVKTINEIYLATDQDREGETIAFH 108 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L+EV+ + Y R++F+EIT+ AI ++ ++++ VNA +ARR +DR+ GY +SPL Sbjct: 109 LKEVLKIKN--YKRMIFHEITETAITESLKNTRNIDMNLVNAGEARRILDRLYGYTISPL 166 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV-------------DASTTTP 229 LWKK+A GLSAGRVQSV ++L++E+E+ F ++ + +A Sbjct: 167 LWKKVAYGLSAGRVQSVGLKLLIEKEKTRINFKKANYYSILLQCKHEKKNLLLEAKLEEI 226 Query: 230 SGEALALQVTHQND--------KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 G+ +A N+ K + L + ++ E K P Sbjct: 227 DGKNIAEGKDFVNETGKLKNIAKTTIITQDLMIELEKELKNGQKIELISIETKKIKIPPP 286 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 PF TSTLQQ + RL G K+ M AQ+LYE GYITYMRTDS N+++ A + + I + Sbjct: 287 KPFTTSTLQQEINKRLKIGTKQIMQHAQKLYEHGYITYMRTDSHNIAKIAKDKITKIIKN 346 Query: 342 NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 +GK+Y+ E Y ++ +Q AHEAIRPS++ + E+++ A+++Y++IW + + Sbjct: 347 KYGKEYIEEKDRIYEKEKMAQNAHEAIRPSEIFIPNETIEIESKTAKEIYKIIWDRTIIS 406 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTL 461 M A ++ LT + ++ + FDG+ K + + + KGD ++ Sbjct: 407 GMKDAIKENIKLTFKYKNLIFRSSFTKIIFDGFLKHTKEQDEHL-NINFDLIKKGDTFSI 465 Query: 462 VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521 V++ ++H TK P R++EASLV+++EK GIGRPSTY++IIST+ +R Y N Sbjct: 466 VKMKTSEHETKAPFRYTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNNTLMPTI 525 Query: 522 MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 G V + LE+ F L+ +FT+ ME LD++A + + L F++ D + Sbjct: 526 KGAAVINLLEKYFPVLIELNFTSNMEEKLDKIAIGKLDKIKYLSKFYNGKKGLKDTVMQL 585 Query: 582 PEEGGMRPNQMVLTSIDCPTCGR-KMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEN 640 + + V+ S I G +L G+ + NL ++ Sbjct: 586 EPKIDSSEFRTVIESQKIENKNSINYTINIGKYGPYLIFKGHNYSINAK-TPLENLYKKD 644 Query: 641 EVLNVLEGEDAETNALRAK 659 E+ ++ ++ + N L Sbjct: 645 EIEKIINEKELKPNILGVD 663 >UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0_BURP8 Length = 908 Score = 484 bits (1247), Expect = e-135, Method: Composition-based stats. Identities = 182/801 (22%), Positives = 310/801 (38%), Gaps = 120/801 (14%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M KAL+I E P+ A I + LG D+V+ S+VGH+ ++ K Sbjct: 23 MSKALIIAEKPSVANDIARALGGFTKHDEYFESDDFVLSSAVGHLLEIAAPEEYEVKRGK 82 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLA 109 + P ++P E+ +VL K++ + D + A Sbjct: 83 WSFANLPVIP---------PHFDLNPIAKSESRLKVL---NKLIKR-----KDVDRLINA 125 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELN--IDRVNAQQA 167 D REGE I + + R+ +T AIR+ F + +A + Sbjct: 126 CDAGREGELIFRLIAQHAK-AKQPVQRLWLQSMTPAAIREGFAQLRTDAEMQPLADAARC 184 Query: 168 RRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 R D +VG + + ++G + GRVQ+ + +VVERE +I+ FVP ++WEV Sbjct: 185 RSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEV 244 Query: 223 DASTTTPSGEALALQVTHQNDK-PFRPVNKE-------QTQAAVSLLEKARYSVLEREDK 274 A SG + K F P ++ + V+ +V E E K Sbjct: 245 KAEFVCASGFYEGRWYDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRGQTGNVTE-ESK 303 Query: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVN 333 P+T A F ++LQ+ A+ R GF K T+ +AQ LYE + TY RTD+ L +D + Sbjct: 304 PSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDYLE 363 Query: 334 MVRGYI-----SDNF---GKKYLPE---SPNQYASKENSQEAHEAIRPSDVNVMAESLKD 382 V+ + S+N+ K+ L + PN+ + H AI P+ ++ K Sbjct: 364 TVKHTMEMLKESNNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPT-----LQAPKA 418 Query: 383 MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR 442 + QKLY L+ ++F+A A+Y TT K G++L GW +V Sbjct: 419 LSEPEQKLYDLVVKRFLAVFFPAAEYRVTTRITEVVGHHFKTEGKVLVEPGWLQVYGRET 478 Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE--------------- 487 G++ ++P V K + + ++ Q TKPPAR++EA+L+ +E Sbjct: 479 GGEDANLVP-VQKDEKVKTDKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELREAM 537 Query: 488 -KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE-ENFRELMNYDFTAQ 545 +G+G P+T A+II + Y+ E R + L + +EL + T + Sbjct: 538 AAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLDVKELTAPELTGE 597 Query: 546 MENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK 605 E L Q+ + A + + TQ + K K+ + + P CP CG + Sbjct: 598 WEYKLSQMERGKLPRDAFMQEI-ARMTQTIVKRAKEYDSDTI-PGDYATLQTPCPNCGGQ 655 Query: 606 MGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKC 665 + Y +C+ +++ +P + E E+ Sbjct: 656 VK------------ENYRRFACTKCEFSMSKIPGGRQFEIEEVEELLQKKQI-------- 695 Query: 666 GTAMDSYLIDPKRKLHV---CGNNPTCDGYEI----------EEGEFRIKGYDGPIVECE 712 + + R + +++ E+GE P+ C Sbjct: 696 -GPLSGFRSKMGRPFSAILKLSFDDETKNFKLEFDFGQDQGGEDGEAPDFSEQQPVGACP 754 Query: 713 KCGSEMHLKMGRFGKYMACTN 733 KC ++ G C N Sbjct: 755 KCSGKVFE----HGMSYVCEN 771 >UniRef50_C0A759 DNA topoisomerase n=4 Tax=Bacteria RepID=C0A759_9BACT Length = 817 Score = 484 bits (1246), Expect = e-135, Method: Composition-based stats. Identities = 168/818 (20%), Positives = 294/818 (35%), Gaps = 153/818 (18%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 +V+ E P+ A+ I K+LG + + V + GH+ +L + Sbjct: 2 KVVLAEKPSVARDIAKHLGATKRGVGFLEGNGWAVTWAFGHMVELQEPEDYKPEWKAWRL 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P + DP A E + K+L AD I ATD Sbjct: 62 STLPIIPADFALRPRAS----DPDGTARAQLETI----------KKLFLDADEIICATDA 107 Query: 113 DREGEAIAWHLREVIGGDD------ARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNA 164 REGE I ++ G + R+ + +T AI + F PG +A Sbjct: 108 GREGELIFRYIYTWTGCEALPPPLAKPVRRLWISSLTNEAIEKGFQNLAPGSDYDRLYHA 167 Query: 165 QQARRFMDRVVGYMVSPLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 + R D +VG + + R LS GRVQ+ + ++V R+ +++ F PE+FWE Sbjct: 168 ARCRSEADWIVGLNATRFFTVEYGRRNLLLSLGRVQTPILAMIVGRDLDVEHFKPEDFWE 227 Query: 222 VDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 V + + + A + T Q + QA V + + K + P Sbjct: 228 VHTLCRSATFKHTAGKFTVQ----------TEAQAIVDRITGHELVIKNVTKKNALTHPP 277 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ-------DAVNM 334 + + LQ+ + R G +T+ +AQ LYE+ ++TY RTDS LS ++ Sbjct: 278 LLYDLTGLQRDMNKRHGLTADQTLRLAQSLYESKHLTYPRTDSCYLSTDIQPTIGPLLDR 337 Query: 335 VRGYISDNFGKKYLPE-SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 +R GK + ++ + H AI P++V D+ D K+Y Sbjct: 338 LRALKPAEIGKLDTGALAFSKRIIDDKKVSDHHAIIPTNVLG-----GDLTGDEAKVYDA 392 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE------- 446 + + +A P TT+ + +ARG +L GW + D+ Sbjct: 393 VLTRLIAVFYPPCIKAVTTVEAESAGEPFRARGTVLVDPGWQALYGGDVSDDDAGTGTKA 452 Query: 447 ------------------------------DRILPAVNKGDALTLVELTPAQHFTKPPAR 476 + LP +G+ E + Q T P R Sbjct: 453 KKASKNAAKKDADENESGESDAKDSDAADSAQQLPDFQEGER-NPHEPSLPQFKTSAPKR 511 Query: 477 FSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 F+EASL++ +E +G+G P+T A+II + RGYV + + + Sbjct: 512 FNEASLLQLMETAGKIVTDETLKEALKDKGVGTPATRAAIIEVLITRGYVERKKKNLIST 571 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK 580 G + +++ L + + T E L Q+ E E + + + + L K Sbjct: 572 DSGRALISLVQD--ERLKSPELTGDWEYRLRQIERGEYEPRVFMSEVEAYTREIL----K 625 Query: 581 DPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPK-----ERCKTTIN 635 + E + + + CP C + TG GCS + K + TI Sbjct: 626 NRAEQTINLSNL----GPCPACHAPVM--RGRTG--YGCSQWRGGCKFVLPGDYLGLTIT 677 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE 695 V E+L + ++ C + + +D K L +++ Sbjct: 678 PVLAREILIHKHTLAPQPVVIKQS-PC------LATLRLDKKGAL----------THDVV 720 Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN 733 + + + C CG ++ + +G C+N Sbjct: 721 QQVNKAGEGSDTLGRCPACGGDIVAGVKAYG----CSN 754 >UniRef50_Q21RE9 DNA topoisomerase III n=34 Tax=Bacteria RepID=Q21RE9_RHOFD Length = 1017 Score = 483 bits (1243), Expect = e-134, Method: Composition-based stats. Identities = 184/826 (22%), Positives = 309/826 (37%), Gaps = 138/826 (16%) Query: 3 KALVIVESPAKAKTINKYL---------------GSDYVVKSSVGHIRDLPTSGSAAKKS 47 K L+I E P+ A+ I + L YVV S+VGH+ ++ K Sbjct: 17 KTLIIAEKPSVAQDIVRALTPVAGKFDKHDEHFESDSYVVTSAVGHLLEIQAPEEFDVKR 76 Query: 48 ADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK--ADH 105 + P + + + + ++ + +LA++ D Sbjct: 77 GKWSFAHLPVIPPHFD-------------------LKPVDKTKTRLNAVVKLAKRKDVDQ 117 Query: 106 IYLATDLDREGEAIAWHLREVIGGDD---ARYSRVVFNEITKNAIRQAFNKPG--ELNID 160 + A D REGE I + + GG R+ +T AIR FN E + Sbjct: 118 LINACDAGREGELIFRLIEQYAGGAKPLGKPVRRLWLQSMTPQAIRDGFNTLRSNEQMLP 177 Query: 161 RVNAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFV 215 +A + R D +VG + + +R + GRVQ+ + +VVERE +I+AFV Sbjct: 178 LADAARCRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRAFV 237 Query: 216 PEEFWEVDASTTTPSGEALALQVTHQNDKPF------------------RPVNKEQTQAA 257 ++WEV A+ +G+ A Q K R + + QA Sbjct: 238 SRDYWEVHATFAAQAGDYPAKWFDPQWKKAAANAAAGNLEEADPELKADRLWQQREAQAI 297 Query: 258 VSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY- 316 + SV E E KPTT F ++LQ+ A+ + GF K T+ +AQ LYE Sbjct: 298 ADAVRGQTASVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKA 356 Query: 317 ITYMRTDSTNLSQDAVNMVR---GYISDNFGKKYLPES----------PNQYASKENSQE 363 +TY RTDS L +D + +V+ +S + + P + P++ + Sbjct: 357 LTYPRTDSRALPEDYLPVVKQTFEMLSKSAMRHLAPHALTALNNNYIRPSKRIFDNSKVS 416 Query: 364 AHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLK 423 H AI P+ ++ + QK+Y L+ R+F+A A+Y TT A K Sbjct: 417 DHFAIIPT-----LQAPSGLSEAEQKIYDLVVRRFMAVFFPNAEYQITTRISVAAGHSFK 471 Query: 424 ARGRILRFDGWTKVMPAL-----------RKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 G++L GW + + GD+ + L V G+ +T + T+ Sbjct: 472 TEGKVLVKPGWLAIYGKEAVDEVTDRDGAKDGDKGQRLVPVQAGERVTAQTVEARGLKTR 531 Query: 473 PPARFSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVENRR 516 PPAR++EA+L+ +E ++G+G P+T ASII + + Y+ E R Sbjct: 532 PPARYTEATLLGAMEGAGKTIEDDELRAAMHEKGLGTPATRASIIEGLLTQKYMLREGRE 591 Query: 517 FYAEKMGEIVTDRLE-ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 + L + +EL + T + E+ L + + + + + + + Sbjct: 592 LIPTASAFQLMTLLRGLDVKELSKAELTGEWEHKLALMEHGQLSRAEFMAEIAAMTERMV 651 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 +A++ + P + CP CG + C+G +E C + Sbjct: 652 KQAKEYDRD--TVPGNYATLTAPCPNCGGIIKENYRRYT----CTG-KTGAEEGCGFSFG 704 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCG----------TAMDSYLIDPKRKLHVCGN 685 P V E E LR K+ P G M + + + + Sbjct: 705 KTPAGRTFEVAEVEQF----LRDKKIGPLEGFRSKAGWPFTAEMVIKFDEESKNYKLEFD 760 Query: 686 NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMAC 731 D E GE + C KCG+ + GK C Sbjct: 761 FGD-DKKGEESGELIDFSGQESLGACPKCGAPVFE----HGKNYVC 801 >UniRef50_Q12Y06 DNA topoisomerase n=1 Tax=Methanococcoides burtonii DSM 6242 RepID=Q12Y06_METBU Length = 780 Score = 483 bits (1243), Expect = e-134, Method: Composition-based stats. Identities = 180/814 (22%), Positives = 326/814 (40%), Gaps = 75/814 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK-K 61 +V E A I+ L +S I D + + + A Sbjct: 2 TTVVFTEKNKAAAQISTILSGGSAKRS----IVDGVSVYEFQRDGSLWKIMGLAGHIMGY 57 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 D N VDP + K S + ++++ AD + LA D DREGE I + Sbjct: 58 DYPEEFHNWRDVDPAALLDTDPVKQINKASFGSAILKISKGADLLVLACDFDREGENIGF 117 Query: 122 HLREVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 + + DA R F+ ++K+ I +AFN E + + + +AR+ +D +G + Sbjct: 118 EAKSIAEKVSDATVKRARFSSLSKSEIEKAFNDLVEPDENMAMSAEARQILDLKMGASFT 177 Query: 181 PLLWKKIAR------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEAL 234 + + LS G Q+ V ERE I+ F +FW+++ T + + Sbjct: 178 RFVTLSVRERARTKGVLSIGPCQTPTCGFVYERELAIRKFDSRDFWKIEGVFTGKGADII 237 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED-KPTTSKPGAPFITSTLQQAA 293 + + +KE+ A L+ + +V+ ++ K + P P T+ + A Sbjct: 238 GVH------RGGHIYDKEKAAAIFKKLKGCKTAVISKKTVKEMNTNPPFPLNTNEFLKRA 291 Query: 294 STRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGYIS---DNFGKKYL 348 S LG + + +A++LY +G+ +Y RT++ + D ++++G+ +F L Sbjct: 292 SKYLGVSPDQALEIAEQLYLSGFTSYPRTETNMYADDMDFASILKGFTKGDYQDFALLLL 351 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDME-ADAQKLYQLIWRQFVACQMTPAK 407 + + + H I P E + ++ A +Y LI R F+A + PA Sbjct: 352 SQKAIVPRNGKKDGHDHPPIHPIKAGSRMEVERAIKMPRAWDVYDLIVRHFIANLLPPAV 411 Query: 408 YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 ++ T + D + G I + GW V P + +D+ILPA++ G+ L + ++T Sbjct: 412 FEKTRFEITMEDELFDSTGSIQKNAGWLAVYPFEKP--QDKILPALDLGEVLDVKKITNI 469 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 + T PP R +EA L+ ++K GIG +T S I T + RGY V+ + G + Sbjct: 470 KSQTTPPKRLTEAELLTLMDKHGIGTKATAPSHIETNKKRGYFEVKGKTIAILDTGFTLM 529 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 D L + L+ D + +E+ + V + +++ L+ S + + + + Sbjct: 530 DALNSSVPILVKPDIRSSIESLIQDVEDGNKKFELALEEGTSLIKEMYSQLLSNRDLMVT 589 Query: 588 RPNQMVLTS----------IDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV 637 R + C C R + I + G F+GC+GY +CK T L Sbjct: 590 RIAGTITDEAVEADKKSHIGKCNECERVLRIVSTDKGRFVGCTGYP-----QCKNTFPL- 643 Query: 638 PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEG 697 P+ L A++ R C K G A+ L + G P C ++E+ Sbjct: 644 PKTGAL-----------AVQRSRTCKKGGAAV---LKVGSKYFWAVGIGP-CFSCDMEKE 688 Query: 698 EFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVP 757 + + EC C + L + +++ CT + C +T+ + +NG + Sbjct: 689 CYP----PEIVGECPACDGQTFLITTKDSRFLGCT-KRCGHTQSVPKNGRLT-------- 735 Query: 758 LPELPCEKSDAYF--VLRDGAAGVFLAANTFPKS 789 + + CE V G AN K Sbjct: 736 ITDKVCEGCGWRLLRVKEQGKDAKEYCANR--KC 767 >UniRef50_UPI0001C314B9 DNA topoisomerase III n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C314B9 Length = 754 Score = 481 bits (1237), Expect = e-134, Method: Composition-based stats. Identities = 152/740 (20%), Positives = 272/740 (36%), Gaps = 103/740 (13%) Query: 1 MGKALVIVESPAKAKTINKYL------------GSDYVVKSSVGHIRDLPTSGSAAKKSA 48 M K LVI E P+ + +++ L G D+++ +VGH+ L K Sbjct: 1 MPKTLVIAEKPSVGRDLSRVLAGPFRRGEGFLEGPDHILTWAVGHLVQLAEPDEYDDKFK 60 Query: 49 DSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HI 106 P+K R ++ ++ +K+ + D + Sbjct: 61 RWRMADLPIVPEKFRLVVRDER------------------SKRQMNVVKRQLGRDDIGVV 102 Query: 107 YLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNA 164 A D REGE I +L E G R+ + +T+ AIR AF + + +A Sbjct: 103 VNACDAGREGELIFAYLYEKAG-SRLPVQRLWLSSMTQTAIRNAFGQLRDGAEMKSLEDA 161 Query: 165 QQARRFMDRVVGYMVSPLLWKKIA----RGLSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 ++R D +VG + ++ +S GRVQ+ + ++ RE EI+AF PE +W Sbjct: 162 ARSRSEADWIVGMNSTRAATIRLRSSFDGAVSLGRVQTPTLAILARREEEIRAFRPEPYW 221 Query: 221 EVDASTTTPSGEALALQVT----HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPT 276 VDA+ + + + R + E A V + + E + Sbjct: 222 TVDATFAASGERVYDGRFHVTAGSGDGRGPRIGSAEFAAAVVEACRGTDGVITKLEKRKR 281 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMV 335 + + ++LQ+ A++R GF ++T+ AQRLYE +TY RT S L D + + Sbjct: 282 RERVPLLYDLTSLQRDANSRFGFSARRTLAAAQRLYEEHKALTYPRTASRYLPTDMIPEI 341 Query: 336 RGYIS-------DNFGKKY---LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEA 385 + G +Y L P + H AI P+ + M Sbjct: 342 KPIAEIVGGRSEYAAGARYVLGLDVLPLARVVNDARVTDHHAIIPT---RAPHPVDRMGD 398 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD 445 D +++Y L+ ++F+A A++++T++ + RG+++ GW V + Sbjct: 399 DDRRIYDLVAKRFLAVFHPDAEFENTSVETEVAGHAFRTRGKVMLVPGWRGVYGESADAE 458 Query: 446 ---------EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR------- 489 ++ LP + +G+ + E+ Q T+PP R+SE SL+ +E Sbjct: 459 PREGEEDEGREQQLPKLEQGEDVQTREIRSEQKETRPPRRYSEGSLLAAMETAGKLVDEE 518 Query: 490 ---------GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY 540 GIG P+T A+II + GY+ + R + G V L+ + L + Sbjct: 519 ELREAMKDSGIGTPATRAAIIERLLAVGYIERDGRALVVTEKGLNVIRLLDGHP--LTSP 576 Query: 541 DFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP 600 T E+ L ++ +E +A + + + + + + + CP Sbjct: 577 SLTGDWEHRLGKIELNEDSRRAFMADIVKFAESTVAELDAKLRDVRIPRANL----GPCP 632 Query: 601 TCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKR 660 CG I G C C I G+ R Sbjct: 633 VCGHD--IMENRKG--FSC---WSRDDPGCGFVIW--------KSKAGKTLSGAIARELI 677 Query: 661 RCPKCGTAMDSYLIDPKRKL 680 R + + + R Sbjct: 678 RTGRTEKPVTGFRSRAGRSF 697 >UniRef50_Q3BT95 DNA topoisomerase n=14 Tax=Gammaproteobacteria RepID=Q3BT95_XANC5 Length = 670 Score = 481 bits (1237), Expect = e-134, Method: Composition-based stats. Identities = 156/685 (22%), Positives = 263/685 (38%), Gaps = 90/685 (13%) Query: 5 LVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 L + E P++ K I + LG S V +GH+ + + ++ + Sbjct: 3 LFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQLKRWSIE 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 + P++ EV P +K L KA + +ATD D Sbjct: 63 QLPIIPQR-------------------WQVEVKPKTATQFKVVKALLAKATQLVIATDAD 103 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRFM 171 REGE IA + ++ G R+ + + +IR A K + + AR Sbjct: 104 REGELIAREIIDLCG-YRGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRA 162 Query: 172 DRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D +VG +S L + LS GRVQ+ ++LVV+R+REI AFV +W +D Sbjct: 163 DWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVYL 222 Query: 227 TTPSGEALALQVTHQ---NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 TT A ++ +D QAA + V+ E + P P Sbjct: 223 TTSGQAFTAQWISPDTCTDDSGRCLQQPVAQQAAQQIRATGSAQVVSVETERVREGPPLP 282 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGYISDN 342 F TLQ+ S +LG V++T+ +AQ LYE TY R+DS L + V + Sbjct: 283 FDLGTLQELCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSL 342 Query: 343 FGKKY--------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 + L + A + AH I P+ + +L M +Y+LI Sbjct: 343 LKTDFSLRPIIDQLDRTQRSRAWNDAKVSAHHGIIPT---LEPANLSAMSEKELAVYKLI 399 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE------DR 448 ++A + ++D T + G L A G+ + GW V+ + ++ + Sbjct: 400 RAHYLAQFLPHHEFDRTVANLSCGQQTLTATGKQVVVKGWRLVLAEPQPEEDSDTAARSQ 459 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE-----------------KRGI 491 +LPA+ +G + + ++ T+P +++ LVK ++ GI Sbjct: 460 VLPALREGVSCQVADVDLKALKTQPSRPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGI 519 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G +T A+IIS + RGY+ + R A + D + + + TA E +LD Sbjct: 520 GTEATRANIISGLIARGYLMKKGRAIRASDAAFTLIDAVPAA---IADPGTTAVWEQALD 576 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 + + + + +Q + + + V CP CG R+ Sbjct: 577 MIEAGQLTLDVFIGKQAAWISQLITQ------YASASLSIKVPHGPACPQCGAPTHQRSG 630 Query: 612 STGVFLGCSGYALPPKERCKTTINL 636 +G F CS Y CK T+ + Sbjct: 631 KSGPFWSCSRYP-----DCKGTLPV 650 Score = 55.9 bits (133), Expect = 7e-06, Method: Composition-based stats. Identities = 8/30 (26%), Positives = 14/30 (46%) Query: 763 CEKSDAYFVLRDGAAGVFLAANTFPKSRET 792 C + A R G +G F + + +P + T Sbjct: 618 CPQCGAPTHQRSGKSGPFWSCSRYPDCKGT 647 Score = 46.2 bits (108), Expect = 0.006, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 19/35 (54%), Gaps = 1/35 (2%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKI 742 C +CG+ H + G+ G + +C+ +CK T + Sbjct: 616 PACPQCGAPTHQRSGKSGPFWSCSRYPDCKGTLPV 650 >UniRef50_C4XEP1 DNA topoisomerase n=2 Tax=Mycoplasma RepID=C4XEP1_MYCFE Length = 629 Score = 480 bits (1235), Expect = e-133, Method: Composition-based stats. Identities = 204/659 (30%), Positives = 329/659 (49%), Gaps = 61/659 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 LVIVESP K +TI KYLGSDY V +SVGHI + T D Sbjct: 5 NNLVIVESPNKVETIKKYLGSDYDVIASVGHIAIMSTRKGEQGLGIDL------------ 52 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 NWE Y + K+ V+ LK+ KAD IY+ATD DREGEAI H Sbjct: 53 --------------ENWEPFYSLDNSKKNVIKNLKEAIAKADVIYIATDPDREGEAIGDH 98 Query: 123 LREVI-----GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGY 177 + + + +Y R+ +NEITK AI++A P EL+ + +N+Q+ARR +DR++G+ Sbjct: 99 IVNFLIEKDRNKNKKKYYRIKYNEITKEAIQKAIQNPTELDQNLINSQKARRMLDRIIGF 158 Query: 178 MVSPLLWKKIA---RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEAL 234 +S L+ KKI+ R SAGRVQS+A++LVV+RE EI AFVP + +V+A ++ Sbjct: 159 KLSQLMQKKISNSPRTPSAGRVQSIALKLVVDREDEINAFVPRGYHKVEAKLNETLSASI 218 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 + +K + V E+ + + +VLE ED K A + Q Sbjct: 219 YIDKHPAAEKNW--VYPEELEKVKEQISIEPINVLEVEDIKEARKTLAKYTPLK-QAVLY 275 Query: 295 TRLGFGVKKTMMMAQRLYE----AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 + K+T + AQ+LYE G I+Y RTDST LSQ +N+ R YI + FG++Y+ + Sbjct: 276 KKSPLTSKQTQIAAQKLYEGYGDGGLISYPRTDSTRLSQHFLNIARSYIKNKFGEEYILQ 335 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLK---DMEADAQKLYQLIWRQFVACQMTPAK 407 +A Q+AHEAIRP+D+N++ E K +++ +Y+LI+ + + P Sbjct: 336 EIKGFA---GDQDAHEAIRPTDINLLPEVAKAKFNLDNSEYIVYKLIYEHTLMSLINPPI 392 Query: 408 YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 + T T KA F G+ V + +ED P + ++E Sbjct: 393 KANKTYTFKKNKLTFKANVSKTIFPGYYLV----KNENEDIEDPNYQIQQKVDVLEYQIT 448 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 H TKPPAR++E SL++ L+ +GRPST+A+ ++ +R Y ++ + + G +V Sbjct: 449 NHETKPPARYTEGSLIEALDNIKVGRPSTFATTVAVNLERKYFENIDKSLHHTEFGRLVL 508 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 +L + F +++N +TA++E LD +A+++ + ++ F+ F + + A + E + Sbjct: 509 SKLLDGFPDIINEGYTAEVEEQLDLIASNKTTVQPIMYDFWKRFNKTYENATETLELIAI 568 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTG--VFLGCSGYALPPKERCKTTINLVPENEVLN 644 + + CP G ++ +R F+GC+ + +C ++ E Sbjct: 569 ---ALEYLNEKCPDDGGELIVRNNKRNDTKFVGCANFP-----KCHYARSVEGEENKRP 619 Score = 42.8 bits (99), Expect = 0.068, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 15/45 (33%), Gaps = 2/45 (4%) Query: 760 ELPCEKSDAYFVLRDGAAG--VFLAANTFPKSRETRAPLVEELYR 802 C ++R+ F+ FPK R+ EE R Sbjct: 574 NEKCPDDGGELIVRNNKRNDTKFVGCANFPKCHYARSVEGEENKR 618 >UniRef50_A3EW25 DNA topoisomerase n=3 Tax=Leptospirillum RepID=A3EW25_9BACT Length = 684 Score = 479 bits (1232), Expect = e-133, Method: Composition-based stats. Identities = 148/672 (22%), Positives = 254/672 (37%), Gaps = 83/672 (12%) Query: 5 LVIVESPAKAKTINKYL------GSDY------VVKSSVGHIRDLPTSGSAAKKSADSTS 52 L I E P+ + I + L G+ + +V GHI + +K A Sbjct: 3 LFIAEKPSLGRAIAEVLPGPHKKGAGFLETGGGIVTWCFGHILEAAPPEEYDRKWAAW-- 60 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 G P +P + ++ +++L +A I A D Sbjct: 61 ---------------PGSSGDLPIVPKTWKLSPVPSAKAQLAVIRKLLGEASEIVHAGDP 105 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI--DRVNAQQARRF 170 DREG+ + + E +G + R+ + + + A+RQA + A Q R Sbjct: 106 DREGQLLVDEVLEYLG-NRKPVLRIWLSSLDEKAVRQALSGLRSNREFAAMKEAAQVRSR 164 Query: 171 MDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 D +VG +S + LS GRVQ+ ++LVV+R+REI++FV ++F+ V+A Sbjct: 165 ADWLVGMNLSRAYSIAARKNGNPVAVLSIGRVQTPTLKLVVDRDREIESFVSKDFFTVEA 224 Query: 225 STTTPSGEALALQVTHQN----DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 + P G + + +N D R +++ + + + +L+ + P Sbjct: 225 TLEAPGGAFKTVWMPAENHPALDAAGRCIDRTVALGVANGTKAQK-GILDIGKTEKSEPP 283 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS 340 + STL AS + K+ + AQ LYE TY RTD L Q R +S Sbjct: 284 PLVYALSTLTMDASKKYAMSAKEVLDTAQSLYEKKLTTYPRTDCEYLPQTQWGEAREILS 343 Query: 341 DN-------FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 + A AH I P+ A + +++ L Sbjct: 344 ALGRLPGLSSAASQADSARRSRAWNTEKVTAHHGIIPT---REAGRAGGLSEKEVRIFDL 400 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE----DRI 449 + R+++A P +Y T + G +A+G GW V ++ + Sbjct: 401 VCRRYLAQFYPPFRYTETIVRTRLGGEPFQAKGTTPLDTGWKSVYGPEPDREDRKEPEPP 460 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIG 492 LPA++ GD + + + T PP+ +++ +LV + E G+G Sbjct: 461 LPALSSGDPVVARDCSVVARKTTPPSPYTDGTLVAAMKNVHRAMSNPEDKKILNETDGLG 520 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 +T ASI+ T+ RGY+ R + G + D +E + + TA E SL+ Sbjct: 521 TEATRASILETLFSRGYLEKSKRAIRSTPRGRALIDAVE---PIVASPVTTAVWERSLES 577 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAS 612 +A + E F S + + K + + + C CG + Sbjct: 578 IATGQGENS---GEFLSKIVDTVSRLTKTALALRV---VIPVEGKICSECGGVLRRLEGK 631 Query: 613 TGVFLGCSGYAL 624 G FLGCSGY Sbjct: 632 FGPFLGCSGYPA 643 Score = 49.7 bits (117), Expect = 5e-04, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 14/36 (38%) Query: 756 VPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRE 791 +P+ C + +G G FL + +P R Sbjct: 611 IPVEGKICSECGGVLRRLEGKFGPFLGCSGYPACRH 646 >UniRef50_Q5UQB5 DNA topoisomerase 1 type prokaryotic n=1 Tax=Acanthamoeba polyphaga mimivirus RepID=TOP1P_MIMIV Length = 854 Score = 479 bits (1232), Expect = e-133, Method: Composition-based stats. Identities = 235/826 (28%), Positives = 363/826 (43%), Gaps = 133/826 (16%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+++ESP K I+ LG +YVVK+S+GH RDL Sbjct: 3 ILILLESPGKISKISSILGKNYVVKASMGHFRDL-------------------------- 36 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +M +D +++E Y V K VV LK + D +YLA D DREGEAIA L Sbjct: 37 ---DPKKMSIDFDNDFEPVYIV--TKPDVVKNLKSAMKNIDLVYLAADEDREGEAIAQSL 91 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 +V+ + Y R+ FN ITK+AI A G+++ + V+AQ+ARR +DR+ GY++SP+L Sbjct: 92 YDVLKPSN--YKRLRFNAITKDAIMSAIKNAGDIDKNLVDAQKARRVLDRLFGYLISPIL 149 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEE----FWEVDASTTTPSGEALALQVT 239 ++I LSAGRVQSV VR+++++E EIK F+ + +++V + Sbjct: 150 QRQIGGKLSAGRVQSVTVRIIIDKENEIKNFINKNADSSYFKVSGTFNGAKATLHESNDK 209 Query: 240 HQNDKPFRPVNKEQTQAAVS-------------LLEKARYSVLEREDKPTTSKPGAPFIT 286 D K A ++ K+++ + EDK TT P PF T Sbjct: 210 KPFDLETAYKGKTAQIALINSENPNSKVVNFMKRCLKSQFFIHSVEDKMTTRSPAPPFTT 269 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 STLQQ A+ + G + TM AQ+LYE GYITYMRTDS +S + ++ I+D +G Sbjct: 270 STLQQEANRKFGMSIDSTMKTAQKLYEGGYITYMRTDSVEISAEGHRDIKKIITDQYGAD 329 Query: 347 YLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTP 405 Y N Y +K NSQEAHEAIRP+ ++ + +A KLY+LIW++ +A QM P Sbjct: 330 YY--QKNLYKNKAANSQEAHEAIRPTHPELLTLEGEIEDAYQIKLYKLIWQRTIASQMKP 387 Query: 406 AKYDSTTLTVGAGDFR---------LKARGRILRFDGWTKVM-PALRKGDEDRILPA--- 452 AK T + + + +++ + F G+ KV ++ D D + Sbjct: 388 AKIKVTIIQISISKYVEDKLNPFYYFQSQIETVVFPGFMKVYVESIDDPDTDNQITKNFT 447 Query: 453 ---VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 G +T+ E+ Q + +PP R+SEASLVK+LE+ GIGRPSTY + I TI +R Y Sbjct: 448 GKIPTVGSKVTMEEIIARQEYMRPPPRYSEASLVKKLEELGIGRPSTYVNTIKTIINREY 507 Query: 510 VRV-------------------------------------ENRRFYAEKMGEIVTDRLEE 532 V++ EN++ +G V D L + Sbjct: 508 VKITDVPGIKKDITIYSIKSENKKHIMEVYEDTDTILLGKENKKIVPTNLGITVNDFLMK 567 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 F E ++Y FTA ME LD V+ W ++ F+ +D+ K +Q Sbjct: 568 YFPEFLDYKFTANMETDLDYVSTGTKNWVDIVQDFYDKLKPIVDELSKQ-----KGLSQS 622 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 + G ++ G + K K + + L+ ++ DA Sbjct: 623 SERLLGEDNDGNEITATKTKFGPVV-------RKKIGDKYVYAKIKDPLTLDTIKLSDAI 675 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 K D L ++ N EI++ E +E + Sbjct: 676 KLLEYPKNLGQY--KGFDVLLQKGDYGFYLSYNKENFSLGEIDDPEDINLDTAIKAIEAK 733 Query: 713 KCGS-------------EMHLKMGRFGKYMACTNEECKNTRKILRN 745 K + + + G++G Y+ T K I ++ Sbjct: 734 KANNIAEFNLTENGKKIKAIVLNGKYGYYVQVTRNRIKKNYPIPKD 779 >UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AUL7_RUBXD Length = 702 Score = 478 bits (1230), Expect = e-133, Method: Composition-based stats. Identities = 180/726 (24%), Positives = 302/726 (41%), Gaps = 60/726 (8%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+I E A+ I ++L V + G R +P + + + Sbjct: 3 LIISEKANAARKIAQFLAEGPVKE---GKHRSVPYHTFTWRGEECVSVGLKGHVLNPEYP 59 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 N VDP +A ++ V + ++ LA+KAD + +ATD DREGE I Sbjct: 60 EEYSNWQKVDPRELIDARILKSVSEKGVAAAVRSLAKKADRVIIATDFDREGELIGVEAL 119 Query: 125 EVIGGDDA----RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 + + R F+ +TK + +AF E++ + +A +AR+ +D + G ++ Sbjct: 120 SLAFEANPALMDHVERARFSALTKGEVTRAFENLVEVSRELADAGEARQDIDLIWGATLT 179 Query: 181 PLLWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 + + + R LS GRVQS + L+ ERE E +AFVPE +WEV+A G +A Sbjct: 180 RWVSRAVKRYGSAFLSVGRVQSPTLVLIAERELERRAFVPEPYWEVEARLQNGGGPFVAR 239 Query: 237 QVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 R + + + A+ L + V E + T APF T+ AA+ Sbjct: 240 HA------RGRFKEEAEARRALENLSE-TAVVTEVRQREATRPAPAPFNTTAFLTAAAN- 291 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-VNMVRGYISD-----NFGKKYLPE 350 +G + +A+ LY GYI+Y RTD+T + + V G++++ ++ + L Sbjct: 292 IGVSPSRAARIAEDLYTEGYISYPRTDNTVYPESLDLREVLGFLAEVEGVGDYAGRLLGA 351 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDS 410 H I P+ AE + D K+YQL+ R+F+A PAK Sbjct: 352 GRLTPTRGRRQTTDHPPIYPTGRASRAE----LREDQWKIYQLVVRRFLATLSGPAKTLR 407 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 TTL +G L A G ++ +GW V R+ DE+ LP +++GD + + E Sbjct: 408 TTLRFESGGEPLVAGGTVVTEEGWLAVYHYGRRRDEE--LPRLSEGDEVRVAEAELLAKE 465 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP R+ + L++ +E G+G +T II + DRGY+ + G V L Sbjct: 466 TQPPGRYGQGRLIRLMEDLGLGTKATRPGIIQNLYDRGYIH--GDPIVPTETGMAVAKAL 523 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM--- 587 ++ E+ +++ TA++E S+D ++ +V++ + D E E+ Sbjct: 524 KDFASEIASHEMTARLEKSMDAISEGRVSKDSVVEESRELLRRVYDHLESSEEKFADIVW 583 Query: 588 RPNQMVLTSIDCPTCG--RKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 + T CP CG + + F GC GY C+TT L + +++ + Sbjct: 584 NGIRGDETLGPCPNCGRNLVVRRNRRNRKRFAGCEGYP-----ECRTTFPLPQKGDIIPL 638 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC--DGYEIEEGEFRIKG 703 C CG L R+ V N C + E G Sbjct: 639 -------------GTACEACGLPEIKVL--GGRRPWVTCINMDCPKKQEQRRSREETQAG 683 Query: 704 YDGPIV 709 + P Sbjct: 684 GEEPSE 689 Score = 43.9 bits (102), Expect = 0.026, Method: Composition-based stats. Identities = 17/94 (18%), Positives = 30/94 (31%), Gaps = 13/94 (13%) Query: 705 DGPIVECEKCGS--EMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPEL 761 D + C CG + ++ C EC+ T + + G++ P Sbjct: 589 DETLGPCPNCGRNLVVRRNRRNRKRFAGCEGYPECRTTFPLPQKGDIIPL--------GT 640 Query: 762 PCEKSDAYFVLRDGAAGVFLAANT--FPKSRETR 793 CE + G ++ PK +E R Sbjct: 641 ACEACGLPEIKVLGGRRPWVTCINMDCPKKQEQR 674 >UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0L167_HALNC Length = 680 Score = 478 bits (1230), Expect = e-133, Method: Composition-based stats. Identities = 147/667 (22%), Positives = 258/667 (38%), Gaps = 84/667 (12%) Query: 7 IVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKT 55 + E P++A+ I LG +D VV + GH+ + Sbjct: 5 LCEKPSQARDIAAVLGIQSKDKSSITTADGVVTWAFGHLLE------------------- 45 Query: 56 AKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDRE 115 P + + P + EV + + L ++A + +ATD DRE Sbjct: 46 QAPPDAYDDSLKRWALASLPIAPTQWKVEVKSSAKDQFKAIATLLKRATEVVIATDADRE 105 Query: 116 GEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFMDR 173 GE IA L +G + R+ + + ++++A KP + R D Sbjct: 106 GEMIARELMAFVGF-KGKVQRLWLSALDAASVKKALAALKPSAETAGLYQSALGRSRADW 164 Query: 174 VVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 +VG ++ S GRVQ+ + LVV R+R+I+ F P ++E+ Sbjct: 165 LVGMNLTRAFTLAGCSQGGEGVRSVGRVQTPTLSLVVARDRQIEHFKPVPYFELFGFFEA 224 Query: 229 PSGEALALQVTH-QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + +V D R V++ A S + +V + E K + P PF S Sbjct: 225 GQSFSTKWKVPEGAGDDAGRCVDQSIVDAVASKITGKTGTVSQYETKRISENPPLPFSLS 284 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGYISDNFGK- 345 TLQ+ S + G G ++ + +AQ LYE TY R+D L ++ ++ Sbjct: 285 TLQKTCSAKFGLGAQEVLDIAQALYETHKATTYPRSDCNFLPEEQFQEASSIVTALAKSD 344 Query: 346 -------KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 L S A AH AI P+ ++ M + +++Y+LI RQ+ Sbjct: 345 TEVQGIVDLLDFSRKSPAWNTKKITAHHAIIPTQ---TPPNMDAMSDNERRVYELIRRQY 401 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP-----ALRKGDEDRILPAV 453 +A + +YD T + + + G+I + GW + DE + LPA+ Sbjct: 402 LAQFLPNYEYDRTQIGISIEGELFQTTGKIDQVTGWRVLFGKADASDDEPDDEVQTLPAL 461 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPST 496 +G L L A TKPP+R++E +L+ + E GIG +T Sbjct: 462 TQGQTLPLSHTEIAAKQTKPPSRYTEGTLIDAMQTIGKNITDPRLKAILKENSGIGTEAT 521 Query: 497 YASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 A II+ + +RG++ + ++ + +G + D L ++ + + TA E SL+++A Sbjct: 522 RAGIIANLIERGFITKKGKQVISSDVGRQLIDALPDSVK---SPALTALWEQSLEEIAEG 578 Query: 557 EAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCG----RKMGIRTAS 612 + E T +D+ +K + + DCPTC + Sbjct: 579 KRELAGFEADVVKFITAIIDQIKKQHADAPA----PTRPTADCPTCKAQGQAEKVYSIKK 634 Query: 613 TGVFLGC 619 + C Sbjct: 635 QCHYWHC 641 >UniRef50_Q18AW1 DNA topoisomerase n=19 Tax=Bacteria RepID=Q18AW1_CLOD6 Length = 696 Score = 477 bits (1228), Expect = e-133, Method: Composition-based stats. Identities = 151/678 (22%), Positives = 262/678 (38%), Gaps = 94/678 (13%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 LVI E P+ A+TI LG S Y+V VGH+ L + + ++ Sbjct: 2 ILVIAEKPSVAQTIAAVLGVKEKKDGFLTGSGYIVSWCVGHLVGLAEAAAYGEQYKKWNY 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLAT 110 P+ E Y V KEK LK+L +AD + A Sbjct: 62 DSLPILPQ-------------------EWKYTVAADKEKQFKTLKELMHRADVSEVVNAC 102 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQQAR 168 D REGE I + E+ G R+ + + +AI++ F++ G+ + R Sbjct: 103 DAGREGELIFRFVYEMAGC-KKPMRRLWISSMEDSAIKEGFSRLKNGKEYDALFASALCR 161 Query: 169 RFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D ++G + L L+ GRVQ+ ++++V+R+ I F E+++ V + + Sbjct: 162 AKADWLIGINATRLFSVLYNHTLNVGRVQTPTLKMLVDRDAAITTFKKEKYYHVRLALSG 221 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 + R NK + + E ++ + T+ P F ++ Sbjct: 222 AEAASE------------RISNKAEADTLKTTCEASKAVCTSLLKEKKTAAPPKLFDLTS 269 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS-------D 341 LQ+ A+ G+ K+T+ +AQ LYE +TY RTDS+ L+ D + G I Sbjct: 270 LQREANCLFGYTAKQTLDLAQALYEKRLLTYPRTDSSYLTDDMGDTAAGIIKLLCGKFPF 329 Query: 342 NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 GK + PE SK+ S H AI P+ + + L + + + + + + Sbjct: 330 MAGKDFTPELAKVLNSKKVSD--HHAIIPT-MELAKTDLAALPESERNILTIAGARLIMA 386 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR------------KGDEDRI 449 P +++ T ARG+ + DGW ++ R D ++ Sbjct: 387 TAAPHTFEAVTAVFECAGQSFTARGKTVLSDGWKEIDRKYRAILKSKPETDDADSDTEKT 446 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------EKRGIGRPSTY 497 LP +G +H T PP +EASL+ + E++G+G P+T Sbjct: 447 LPPFTEGQNFDNPAAKVTEHDTTPPKPHNEASLLSAMERAGSEDTDPDAERKGLGTPATR 506 Query: 498 ASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHE 557 A++I + G+V + ++ K G + L + L + TA+ EN+L Q+A + Sbjct: 507 AAVIEKLVKGGFVERKGKQLLPTKDGINLVCVLPDT---LTSPQLTAEWENNLTQIAKGK 563 Query: 558 AEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL 617 A+ A + + + E R + CP CG + + Sbjct: 564 ADPAAFMKGIEDMARELVKTYPFLSEADKGRFKEEKPELGKCPRCGSPVY--EGKKNYY- 620 Query: 618 GCSGYALPPKERCKTTIN 635 CS + C T+ Sbjct: 621 -CSN------KECSFTMW 631 >UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=Q4QPE8_HAEI8 Length = 686 Score = 477 bits (1227), Expect = e-133, Method: Composition-based stats. Identities = 149/672 (22%), Positives = 249/672 (37%), Gaps = 84/672 (12%) Query: 4 ALVIVESPAKAKTINKYLGS-------------DYVVKSSVGHIRDLPTSGSAAKKSADS 50 L + E P++ I K LG+ V +GH+ + Sbjct: 7 KLFLCEKPSQGNDIAKVLGATKRGEGCLSTPDGQLTVTWGIGHLVE-------------- 52 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLAT 110 P++ + P + +K + + +L ++A + +AT Sbjct: 53 -----QFNPEEYDPAFKKWAFETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIAT 107 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQAR 168 D+DREGE IA L + + G + R+ + + +IR+A K E + A AR Sbjct: 108 DIDREGETIARELLD-LAGFRGQIKRLWLSALDDTSIRKALGALKNNEETLPLYYAGLAR 166 Query: 169 RFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 D ++G S L + LS GRVQ+ + LVV R+REIK F+P++ + + Sbjct: 167 SRADWLIGMNFSRLYTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFAL 226 Query: 223 DASTTTPSGEALALQVTHQN--DKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTSK 279 + + V + D ++ + QAA + + + V E K Sbjct: 227 QVMLSDGNQHFATQYVIPEQYCDPDGLCLSAQVIQAANQQIRQFGQAKVESVETKRERQN 286 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGY 338 F S LQ A+ G G ++ + +AQ LYE TY RTD L + Sbjct: 287 APLCFALSDLQSEANRLYGLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPQI 346 Query: 339 ISDNFGKKY--------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKL 390 I L + + AH I P+ + + M + KL Sbjct: 347 IQCLLQSDNRLHPLAGMLNLNQKSRVWNDKKITAHHGIIPTMI---KADISKMSDEELKL 403 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED--R 448 Y LI R+++A + ++ D T + + G L ARG +L GW + D+D + Sbjct: 404 YDLIRRRYLAQFLPVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQ 463 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGI 491 LP + +G + + T PP F+E +L+ + E G+ Sbjct: 464 ALPTLKQGQICQISDSEIKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGL 523 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G +T A I + D+G+++ + + A + D L + L + TA E +L+ Sbjct: 524 GTEATRAGTIQGLIDKGFLKKKGKSLLATDEAMTLIDNLPQM---LKDPGLTALWEQALN 580 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 Q+A + + + K G + CP CG M R Sbjct: 581 QIAERTLSLEVFMQKQEVFVRHLMADCLKKGMSLG------NIEIRKCPKCGAPMIKRNG 634 Query: 612 STGVFLGCSGYA 623 G F GCS Y Sbjct: 635 KNGAFFGCSAYP 646 Score = 59.0 bits (141), Expect = 8e-07, Method: Composition-based stats. Identities = 8/31 (25%), Positives = 13/31 (41%) Query: 762 PCEKSDAYFVLRDGAAGVFLAANTFPKSRET 792 C K A + R+G G F + +P + Sbjct: 621 KCPKCGAPMIKRNGKNGAFFGCSAYPNCQHI 651 Score = 48.2 bits (113), Expect = 0.002, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 20/44 (45%), Gaps = 1/44 (2%) Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGE 747 + I +C KCG+ M + G+ G + C+ C++ I Sbjct: 616 NIEIRKCPKCGAPMIKRNGKNGAFFGCSAYPNCQHIENIDSKKN 659 Score = 47.8 bits (112), Expect = 0.002, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 14/39 (35%), Gaps = 1/39 (2%) Query: 660 RRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGE 698 R+CPKCG M C P C E + + Sbjct: 620 RKCPKCGAPMIKR-NGKNGAFFGCSAYPNCQHIENIDSK 657 >UniRef50_C9KMQ0 DNA topoisomerase n=5 Tax=Bacteria RepID=C9KMQ0_9FIRM Length = 821 Score = 476 bits (1226), Expect = e-132, Method: Composition-based stats. Identities = 173/845 (20%), Positives = 297/845 (35%), Gaps = 94/845 (11%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L I E P+ + + K L V G++ + +P++ + Sbjct: 3 LYIAEKPSVGRELAKCLTGP--VTRRDGYLVT-----KDGVVTWLFGHILRQAEPEEYDP 55 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 R P V EK + +K L EKAD I D DREG+ + + Sbjct: 56 KYKRWRADDLPIIPEHWKLFVDKDCEKQFAIVKSLIEKADEIVHGGDPDREGQLLVDEVL 115 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRFMDRVVGYMVSPL 182 + +G + R++ N + + +I++A + + + AR D ++G +S Sbjct: 116 DYLG-NKKPVRRILLNALDEKSIKKANASLRDNRDFFNLKQSALARARADWLIGMNLSRA 174 Query: 183 LWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 R L GRV++ + LVV REREI+ F P ++ + + +G A Sbjct: 175 YTLAARRAGHERLVLPIGRVKTPTLSLVVRREREIEHFKPVTYYLIRGTFQHENGSFEAQ 234 Query: 237 QVTHQN----DKPFRPVNKEQTQAAVSLLEKARY-SVLEREDKPTTSKP-GAPFITSTLQ 290 D R ++K+ ++ E+ + +V+ K +P PF STLQ Sbjct: 235 WKPKDTMAGLDSENRLIDKKIADEKLAFFEELPHDAVISAYQKAKKQEPQPLPFSLSTLQ 294 Query: 291 QAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGK----- 345 A R G+ + + AQ+LYE TY R+D L + + +S Sbjct: 295 VLAGKRFGYAPQLVLDTAQKLYEKKLTTYPRSDCEYLPTNQLGEAATILSHLAKAGDAQV 354 Query: 346 ----KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 K A + AH AI P+ V + M + + LY LI R ++A Sbjct: 355 AAWVKAANPKQKSRAWNDKKISAHHAIIPTTVQ---ADVTKMTQEERNLYHLIARAYLAQ 411 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED-------------R 448 YD T + V D A GR R GW + + +K E + Sbjct: 412 FYPVHTYDQTKVEVQYKDETFTASGRTERDLGWKVMYQSQKKKQESDEEDDKEDKEESAK 471 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK-----------------RGI 491 LPA+ K DA+ + TKPP RF+ ++L+ +++ GI Sbjct: 472 TLPAMKKKDAVAWQRGRMLEKMTKPPTRFTASTLLAGMKEIHKYVKNPEAKKQLKDVYGI 531 Query: 492 GRPSTYASIISTIQDRGYVRVENRR--FYAEKMGEIVTDRLEENFRELMNYDFTAQMENS 549 G +T A+II + R +++ E ++ ++ D L + EL D TA E+ Sbjct: 532 GTEATRATIIDDLIRRKFMKAEGKKKYLVPTPAAYLLVDALPD---ELTYPDSTAIWEDK 588 Query: 550 LDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK-MGI 608 L ++ E L + + KA + V CP C + + Sbjct: 589 LHSMSEGEGSLADFLQGQIAFTRKLCAKA--------TDVHMEVKGENVCPRCHQGVLTK 640 Query: 609 RTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 R GVF GCS Y +C+ T N + + LE A + Sbjct: 641 RKGKNGVFWGCSNYP-----KCRMTCN---DKDGKPDLEDAKARLARRPCAAAPAAVSAS 692 Query: 669 MDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKY 728 ++ P G + + + + E + + Sbjct: 693 ALAWQAHPSSA-QAAGGYSSAESADDIAALNALFSPADYAARMEADAKSYAAQQKKASSS 751 Query: 729 MACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKS-DAYFVLRDGAAGVFLAANTFP 787 ++ K + + + V + C + + + G GVF + +P Sbjct: 752 WQSWADKPKYSASPMEH------MAKDVASSDYLCPRCREGHLRSIYGRNGVFWGCSNYP 805 Query: 788 KSRET 792 + T Sbjct: 806 RCTAT 810 >UniRef50_B2RH95 DNA topoisomerase III n=3 Tax=Bacteroidales RepID=B2RH95_PORG3 Length = 710 Score = 476 bits (1225), Expect = e-132, Method: Composition-based stats. Identities = 141/706 (19%), Positives = 249/706 (35%), Gaps = 105/706 (14%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 + I E P+ + I LG + Y V + GH+ L A + + Sbjct: 37 IVCIAEKPSVGREIAAVLGATKAYKGYMEGNGYQVTWTFGHLCALKEPHDYAPEWKRWSI 96 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P + + + +++L +AD + D Sbjct: 97 SSLPMIPLR-----------------FGIKLIDSDSIREQFGTIEKLVHEADMVVNCGDA 139 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQQARRF 170 +EGE I + + G R+ + +T+ +IR+ F + E A AR Sbjct: 140 GQEGELIQRWVLQKTGC-TCPVRRLWISSLTEESIREGFARLRDSEEFHSLYEAGLARAI 198 Query: 171 MDRVVGYMVSPLLWKKIA---RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D ++G + L + + LS GRVQ+ + L+V R+ EI+ F PE +WEV Sbjct: 199 GDWLLGMNATRLYTLRFGSNRQVLSIGRVQTPTLALIVRRQHEIEHFTPEVYWEVKTIYR 258 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 T N R + E + V ++ + ++V K P F + Sbjct: 259 D----------TVFNATKGRFSSIEDARREVEVVAGSPFAVTSVATKKGRELPPRLFDLT 308 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 LQ + R T+ Q LYE +Y R D+T LS D V + Sbjct: 309 GLQVECNKRFAMTADATLRTIQSLYEKKITSYPRVDTTYLSDDVFEKVPNILQGLSDYTL 368 Query: 348 LPESPN-------QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 L + + H AI P+ M D ++++ L+ R+F+A Sbjct: 369 LTAPLRSSKLKKSKKVFDNSKITDHHAIIPTGQPSH-----GMSEDERRVFDLVARRFIA 423 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPAL------RKGDEDRILPAVN 454 + TT+ A K G+ + GW V DE++ LP + Sbjct: 424 VFYPDCIFSQTTVLGQAAKVEFKTTGKQILEPGWRTVFTDPQTDDDGENKDEEKKLPIFS 483 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRPSTYA 498 +G++ + + T+PP ++EA+L++ +E + GIGRPST A Sbjct: 484 EGESG-VHTPEVQEKTTQPPKFYTEATLLRAMETAGKSVKDEELRDALKENGIGRPSTRA 542 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 +II T+ R Y+ E + A G + ++ + L + + T Q E L ++ + Sbjct: 543 AIIETLFKRNYIYKEKKNLKATPTGMSLIATID--YELLKSAELTGQWEYKLRRIERGDY 600 Query: 559 EWKAVLDHFFSDFTQQLDKAEKD-----------------PEEGGMRPNQMVLTSIDCPT 601 ++ T + K ++ + CP Sbjct: 601 SAADFINELKVLLTHLIPNVLKSNSSVLLSEPIPAASPAPGKKKKADKPMQKQLDLTCPV 660 Query: 602 CGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 CG+ + +R GC+ + +E C + L+ E Sbjct: 661 CGKGIIVR-GREA--FGCNAF----REGCTFRLPYSEYPASLSDNE 699 >UniRef50_C0YH06 DNA topoisomerase n=4 Tax=Bacteroidetes RepID=C0YH06_9FLAO Length = 695 Score = 476 bits (1224), Expect = e-132, Method: Composition-based stats. Identities = 131/652 (20%), Positives = 248/652 (38%), Gaps = 75/652 (11%) Query: 6 VIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTK 54 +I E P+ A+ I + LG + Y V ++GH+ L + S Sbjct: 4 IIAEKPSVAREIAQLLGAHEKKDGYLSGNGYCVTWALGHLISLGMPEDYGIRGFKKASLP 63 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 P L G YE P K ++ ++Q+ ++ I +ATD R Sbjct: 64 IFPNPFILTPKKLKKAKG----------YEPDPSALKQLNTIQQVIKQCSSIIVATDAGR 113 Query: 115 EGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRFMD 172 EGE I ++ + + + R+ + +T+ AI+ F PG+ A +AR D Sbjct: 114 EGELIFRYIYHYLQC-NKPFERLWISSLTEKAIQDGFKNLQPGDAFDGLYQAAKARSEAD 172 Query: 173 RVVGYMVSPLLWKKIARGL-SAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 +VG + L + + S GRVQ+ + L+ +R + + F ++++++ S Sbjct: 173 WLVGINATQALTIGGNQDVYSLGRVQTPTLALICQRFLQHQNFTKQKYFQIQLSHRKEYT 232 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + +L + +K EQ Q + + R V + K + F + LQ+ Sbjct: 233 DFTSLSLLQWEEKK----QAEQIQKIIE--REGRAIVEDVSVKTVQEQSPLLFDLTELQK 286 Query: 292 AASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS--------DNF 343 A+ +LG + + AQ LYE +ITY RT S + +D + + Sbjct: 287 EANRKLGLSADEVLQTAQSLYEKQFITYPRTGSKYIPEDLWTDIPELVRILNQTEPFKAA 346 Query: 344 GKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQM 403 + N+ + H + + ++ + A + +Y +I + + Sbjct: 347 ITHLKFGNFNKRIVNDVKVTDHHGLLITT-----KTPSALSATEKAIYDMIAYRLLESLS 401 Query: 404 TPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR-------ILPAVNKG 456 T + + + + +G + GW + L + LP G Sbjct: 402 HTCTKQVTQIQIKVHHYEFQIKGSKILNKGWRAIKGILSDNENSNNANEDLTELPEFKIG 461 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRPSTYASI 500 D L + + + T+PP ++EA L+ +E GIG P+T ASI Sbjct: 462 DELKISKTELLEKTTQPPKLYTEADLLSVMENAGRSIENKEDQKALSNIGIGTPATRASI 521 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 I T+ R Y+ +++ + G V + +++ +++ N TA+ E +LD++ E Sbjct: 522 IETLLSRNYIVRKSKTLHPTDKGLQVYNLVKD--KKIANVQMTAEWEIALDKIEKGELNK 579 Query: 561 KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAS 612 ++ Q AE E + Q + + CP C + I Sbjct: 580 TQFMNDI------QAYTAEITSELLSLHIPQENIPQLKCPKCQQHNLIIKDK 625 >UniRef50_D1BLQ5 DNA topoisomerase n=3 Tax=Veillonella RepID=D1BLQ5_VEIPT Length = 773 Score = 475 bits (1223), Expect = e-132, Method: Composition-based stats. Identities = 174/788 (22%), Positives = 283/788 (35%), Gaps = 137/788 (17%) Query: 5 LVIVESPAKAKTINKYL---------------GSDYVVKSSVGHIRDLPTSGSAAKKSAD 49 L I E P+ A+ I+K L G D VV VGH+ G K Sbjct: 3 LFIAEKPSMAREISKCLPENKNIQKRNGYFIQGDD-VVTWVVGHVLHQAEPGDYDDKYIR 61 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLA 109 P E V + +K L +KAD I A Sbjct: 62 WRPQDLPIVPA-------------------EWKLLVTDSSRQQFEIVKDLIDKADVIVNA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQA 167 D DREG+ + + +G + R++ N + + +IR A + + + + A Sbjct: 103 GDPDREGQLLVDEVLYYVG-NTKPVQRILLNALDEKSIRSALDDLRDNKDFHNLYQSALA 161 Query: 168 RRFMDRVVGYMVSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 R D ++G +S K L GRV++ + LVV RERE+ AF P +++ V Sbjct: 162 RARADWLIGMNLSRAYTLSERYKGNKVTLPIGRVKTPTLALVVRRERELAAFKPVDYFTV 221 Query: 223 DASTTTPSGEALALQVTHQNDKPF----RPVNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 P+G A K R +NK + V L+ V++ K Sbjct: 222 KVLYNHPNGVFWATWQPTDEQKGLDPDGRLINKAIADSLVEQLQSGPDGVIKAVTKSKKK 281 Query: 279 KPG-APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 P S+LQ A + + + AQ+LYE TY R+D L + + Sbjct: 282 DVQRLPLSLSSLQVLAGKAFSYDPQTVLDTAQKLYEKKLTTYPRSDCEYLPPNQYDDRNA 341 Query: 338 YIS--DNFGKKYLPE-------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ 388 ++ N G + L + S A E AH AI P+ V A ++ + + + Sbjct: 342 ILNNLQNAGDERLAQWAADADRSIKSRAWNEKKITAHHAIIPTTV---ACNINSLSQEER 398 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM---------- 438 +Y LI + ++A Y+ T + V A GR++ +GW + Sbjct: 399 NIYFLISQAYIAQFYGEHIYEQTKIVVEQCKEEFVANGRVVIEEGWKLLYKRHKSKSTTD 458 Query: 439 ---------------PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLV 483 P +E LPAV K D + + + TKPP+RF+ ++L+ Sbjct: 459 NDEPDLTDERGAESDPKKEIIEETDHLPAVKKNDTVLYTDSSVEAKQTKPPSRFTPSTLL 518 Query: 484 KELEK-----------------RGIGRPSTYASIISTIQDRGYVRVENRR--FYAEKMGE 524 + +++ GIG +T A+II + RG+++ ++ + G Sbjct: 519 QAMKEIHKFVKNEDLKKQLKAVSGIGTEATRANIIDELISRGFMKTSGKKQVLSPTETGY 578 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA--EKDP 582 ++ D L E EL+ D TA E L ++ E + L +DK +K Sbjct: 579 LLVDALPE---ELLYPDETAVWEERLALMSEGEDTLDSFLADQIKFLKLLIDKLGFDKVI 635 Query: 583 EEGGMRPNQMVLTSID------------------CPTCGRK-MGIRTASTGVFLGCSGYA 623 M PN + + CP C + + R G FLGC+ Y Sbjct: 636 NSDQMMPNVVRTITSQNRKRPMDSESVDLSSLPVCPKCKKGRLQQRNGKFGAFLGCTNYP 695 Query: 624 LPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVC 683 CK T + + + + E + + +CP+C R +C Sbjct: 696 T-----CKHTQPVEGDTSSVE----GNIEVSDEDKQYKCPRCNVGYFVKQEVRGRTNWIC 746 Query: 684 GNNPTCDG 691 N C Sbjct: 747 SNRSQCKT 754 Score = 51.6 bits (122), Expect = 1e-04, Method: Composition-based stats. Identities = 16/56 (28%), Positives = 21/56 (37%), Gaps = 2/56 (3%) Query: 740 RKILRNGEVAPPKEDPVPLPELP-CEKSD-AYFVLRDGAAGVFLAANTFPKSRETR 793 R I P + V L LP C K R+G G FL +P + T+ Sbjct: 646 RTITSQNRKRPMDSESVDLSSLPVCPKCKKGRLQQRNGKFGAFLGCTNYPTCKHTQ 701 >UniRef50_B3PMD8 DNA topoisomerase I n=3 Tax=Mycoplasma RepID=B3PMD8_MYCA5 Length = 620 Score = 475 bits (1223), Expect = e-132, Method: Composition-based stats. Identities = 202/633 (31%), Positives = 325/633 (51%), Gaps = 51/633 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + ++IVESP K KTI +Y+GSDY V SSVGHI L TSG Sbjct: 1 MDQKVLIVESPNKVKTIQQYVGSDYNVVSSVGHILKLSTSG------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 V+ +G+D + NWE K KV+ LK + A + +ATD DREGEAIA Sbjct: 42 -------VDGLGID-FTNWEPMMIQDRTKAKVIKALKDATKNAKEVLIATDPDREGEAIA 93 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +L + + Y R+ +NEIT AI++A P ++ + V AQ+ RR +DR++G+ +S Sbjct: 94 QNLVDTLKLSKI-YRRIKYNEITAEAIKEALENPQMIDDNLVKAQKTRRMLDRIIGFRLS 152 Query: 181 PLLWKKIARGLS---AGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 L+ +K+ S AGRVQS+A++LV ++E+EIKAF+P ++ ++ A + Sbjct: 153 QLMKRKVKNAPSLPSAGRVQSIALKLVCDKEKEIKAFIPIKYNKIQAKISEDVIADFYYP 212 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 + E+ + V+ L K + V + + PF S L + A Sbjct: 213 TNSDFKNDNTWILPEKIDSIVAELNKNKSLLVKDFKVSQRKESQITPFKQSVLYKEA--- 269 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 + + AQ+L+E G I+Y RTDST +S + R YI + FG+ Y+ ++ Sbjct: 270 -KYSATTVQISAQKLFEMGLISYPRTDSTRMSDTFIAKAREYIKEKFGENYVASDIKSFS 328 Query: 357 SKENSQEAHEAIRPSDVNVMAESLK---DMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 +Q+AHEAIRP+D+ ++ + K D+ +Y +I+ + ++ MTP + Sbjct: 329 ---GAQDAHEAIRPTDIYLIPQVAKTKYDLGEVESYIYTIIYNKTMSSLMTPPVREIYRY 385 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKP 473 + G + K + FDG+ +V+ +E + LP G+A+ ++E T T+P Sbjct: 386 ELVNGLYYFKMSYSKVIFDGYYRVLNF----EEPKPLPKYEIGEAIPVLEFTRFDKETQP 441 Query: 474 PARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEEN 533 PAR++E SL+K L+ +GRPST+AS I+ I+ R +V N + GE+V +L E Sbjct: 442 PARYNEGSLIKMLDDIKVGRPSTFASTINIIKKRLFVETINGALHPTVFGEVVLKKLIEG 501 Query: 534 FRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMV 593 F + ++TAQ+E LD+V+ +A++K +L+ F++ F + D A K E M + Sbjct: 502 FPNTITEEYTAQVEEELDEVSEGKADYKILLEDFWNRFQRSYDDASKTIEISIMPQEFLE 561 Query: 594 LTSIDCPTCGRKMGIRTASTG--VFLGCSGYAL 624 + CP CG + R S F+GCS + Sbjct: 562 RS---CPRCGSTLLYRNNSKKHTKFIGCSNFPA 591 >UniRef50_A8MIQ9 DNA topoisomerase n=2 Tax=Clostridiaceae RepID=A8MIQ9_ALKOO Length = 716 Score = 474 bits (1221), Expect = e-132, Method: Composition-based stats. Identities = 160/685 (23%), Positives = 269/685 (39%), Gaps = 88/685 (12%) Query: 3 KALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K LVI E P+ AK I K L GSDY++ ++GH+ L + Sbjct: 2 KRLVIAEKPSVAKDIAKVLNCKEKREGYIEGSDYIITWAIGHLVILCDPEEYDIRYKKWD 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATD 111 P K + K+ + + L+ + D I ATD Sbjct: 62 FNTLPIIPDKIKLKPNPKTY-----------------KQYQIVKALMLSSQIDEIICATD 104 Query: 112 LDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQQARR 169 REGE I ++ E + + R+ + +T IR F G+ + + R Sbjct: 105 AGREGELIFRYIYE-LAKCRKPFQRLWISSLTDEGIRTGFEHLKDGKAYDALYYSAKCRS 163 Query: 170 FMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 D +VG S + L GRVQ+ ++++V+R+ EI FVP+++WEV A Sbjct: 164 ESDWLVGINGSRAYSIQYGSLLPIGRVQTPTLKIIVDRDLEIDDFVPKDYWEVKADFGNY 223 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTL 289 SG + L+ + + ++ + + + V + + K KP + + L Sbjct: 224 SGIWIDLEKNES-----KIDSIQKAEDIKNKVLLKEGLVTDFQKKKVVKKPPFLYDLTEL 278 Query: 290 QQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY- 347 Q+ ++ + G+ ++T+ +AQ LYE ITY RTDS L++D + ++ I+ + Y Sbjct: 279 QRDSNKKFGYTAQRTLDIAQSLYEKRKAITYPRTDSRFLTKDIIPKLKSLINKIGLEGYK 338 Query: 348 --------LPESP-NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 L + P N + H AI P++ + L + + LY LI R+F Sbjct: 339 EFTSILEKLEKLPVNPRIINDRKVTDHHAIIPTEKKI---DLNKFSEEEKNLYDLIARRF 395 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 +A +Y S + K+ + GW + ++ L + KG + Sbjct: 396 LAVFYPDYEYFSIVMITHVAGEDFKSNEQQTIHLGWKLLYSDKEVETKESTLIHIKKGSS 455 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRPSTYASIIS 502 TL Q TKPPAR++EA L+ +E GIG P+T ASII Sbjct: 456 STLKSAEIEQKQTKPPARYNEALLLDSMENAGKFIEDEELKEQLKSSGIGTPATRASIIE 515 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 I GYV + + + + G + +EL + + T + E +LD++A + Sbjct: 516 RIISVGYVERKGKNLISTEKGRKLIQI---TSQELSSPELTGKWEKALDKIAKGNMNPQR 572 Query: 563 VLD---HFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID---------CPTCGRKMGIRT 610 ++ F + + K K+ G N+ +S CP C + Sbjct: 573 FMEGIGRFTKFIIEDVQKNTKNVVFEGYSKNRGKKSSGTSSYNSPIGICPACKVGKVLEG 632 Query: 611 ASTGVFLGCSGYALPPKERCKTTIN 635 CS Y K+ CK I Sbjct: 633 PKN---FYCSEY----KQGCKFGIF 650 >UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DUF7_METI4 Length = 855 Score = 474 bits (1220), Expect = e-132, Method: Composition-based stats. Identities = 171/772 (22%), Positives = 299/772 (38%), Gaps = 115/772 (14%) Query: 1 MGKALVIVESPAKAKTINKYLG------------SDYVVKSSVGHIRDLPTSGSAAKKSA 48 MGK LVI E P+ A+ I + LG ++ S+VGH+ +L + Sbjct: 1 MGKTLVIAEKPSVAQDIAEALGGFPKGRKDIYENDRMIISSAVGHVVELCLPAEMDSRHR 60 Query: 49 DSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYL 108 + + P + H E D I Sbjct: 61 QWSLSNLPILPSSFSLKPIQKHKDRLNLLLSLLHRE-----------------DVDLIIN 103 Query: 109 ATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI--DRVNAQQ 166 A D REGE + +L + R+ +TK+AI +AF L A Sbjct: 104 ACDAGREGELVFRYLIR-FAQVNKPIQRLWLQSMTKDAIIEAFKNLRPLREVEGLACAAV 162 Query: 167 ARRFMDRVVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 +R D ++G + L K R S GRVQ+ + LVVER++EI +F P+ +WE Sbjct: 163 SRSESDWLIGINGTRALTALHSNSKGFRLTSVGRVQTPTLALVVERDKEILSFQPKPYWE 222 Query: 222 VDASTTTPSGEALALQVTH------QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 + A+ + GE A + +++ P R N++Q Q+ + V E E K Sbjct: 223 ILATFRSKQGEYKAKWFSRNSQHEGEDNHPERIENEDQCQSIIEKCLNKEGIVTE-EKKV 281 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNM 334 + P + ++LQ+ A+ R GF ++T+ + Q LYE ITY RTDS L +D V Sbjct: 282 SQQSPPLLYDLTSLQREANNRFGFSAQRTLQIVQSLYENHKLITYPRTDSKFLPEDYVPR 341 Query: 335 VRGYIS-------DNFGKKYLPESPNQYASK---ENSQEAHEAIRPSDVNVMAESLKDME 384 V+ + + F ++ L ++ Q A+K H AI P+ + Sbjct: 342 VKEVLKNLSHGPFETFAREILSQNWVQPANKIFNNQKVSDHFAIIPTTHKPTT-----LN 396 Query: 385 ADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR-- 442 A+ +K+YQLI R+F+A PA+++ T + + G+IL+ GW KV Sbjct: 397 ANEEKIYQLIVRRFLATFYPPAQWEITKRITVVEEESFRTEGKILKSAGWLKVYRDSNPA 456 Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE--------------- 487 + E+ +L + +G+ + + + TKPPA F+EA+L+ +E Sbjct: 457 QNTEEDVLCPIEQGEKVLNLAMEKIAKETKPPAHFTEATLLSAMESAGKLVEDETLREAM 516 Query: 488 -KRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRLEEN-FRELMNYDFTA 544 K+G+G P+T A II + + GY+R + + A + + L + L + + T Sbjct: 517 AKKGLGTPATRAGIIEGLIEDGYIRRQDGKALVATPKAFALIELLSAAQIQTLRSAELTG 576 Query: 545 QMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK------------------------ 580 + E L + + + ++ + +DKA+ Sbjct: 577 EWEFKLQMMEKEKYSQEKFMEEIYQLTASIVDKAKALGSIANVKKALPLFTPQGKAIEET 636 Query: 581 ----DPEEGGMRPNQMVLTSIDCPTCGRKMGIRT--ASTGVFLGCSGYALPPKERCKTTI 634 +G N+ + P K+ + F G + + Sbjct: 637 LYEYQAPDGSFHVNKYIAGRPLFPDELEKLISQRTIGPLKGFYNKKGQPFTATLKLEDER 696 Query: 635 NLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNN 686 + + +GED + + + CP +D+ + ++ + C N Sbjct: 697 GTLRFEFEKDESQGEDKQILSEESLGSCP-----IDNSPVLEAKEYYACLNY 743 >UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C5QM86_STAEP Length = 712 Score = 474 bits (1219), Expect = e-132, Method: Composition-based stats. Identities = 166/723 (22%), Positives = 271/723 (37%), Gaps = 91/723 (12%) Query: 1 MGKALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M K+L++ E P+ A+ I L Y+V ++GH+ + Sbjct: 1 MMKSLILAEKPSVARDIADALHIKNKKNGYIENEKYIVTWALGHLVTNAAPEQYDASYKE 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIY 107 PK V+ K +K L +K I Sbjct: 61 WKLEDLPIIPKY-------------------MKTIVIGKTSKQFKIVKSLILDKKVKDII 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQ 165 +ATD REGE +A + + +G + R+ + +TK AI++ F + +A Sbjct: 102 IATDAGREGELVARLILDKVG-NKKPIQRLWISSVTKKAIQEGFKHLKDGRAYNSLYHAA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D +VG + L K LS GRVQ+ ++LV R+ +I F PE+++ + Sbjct: 161 LARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVQSRQDDINHFQPEKYYTLSIK 220 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 + T K F+ NK+ + ++ V++ + K P + Sbjct: 221 VD-------GYEFTFNTQKHFK--NKKDLETIEQQVKNQEGKVIDVKSKHKKLYPQQLYN 271 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYISDNFG 344 + +QQ A R G K+T+ Q LYE I TY RTDS L+ D V+ ++ + Sbjct: 272 LTDIQQDAYRRFKMGPKETLNTLQHLYERHKIVTYPRTDSNYLTHDMVSTIKERLQALLA 331 Query: 345 KKYLPE---------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 Y SP ++ H AI P++V SL+ + K+Y LI Sbjct: 332 TNYKSHVRELIGQSFSPKMSIFNDSKVSDHHAIIPTEVR---PSLEQLSQREFKIYMLIV 388 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNK 455 +F+ M P +Y+ T+ GD + I + G+ + + + Sbjct: 389 ERFLESLMKPYEYEGVTVNFEVGDLMFSLKENIPKQLGFKALKEDTLQPSKSH---QFVI 445 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEK-------------------RGIGRPST 496 G + ++ +H TKPP F+E SL+K +E GIG +T Sbjct: 446 GQQFKVQKVDIHEHETKPPEYFNEGSLLKAMENPQNYIQLDNKKYAQTLKQTGGIGTVAT 505 Query: 497 YASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 A II + + + V + + G+ + + EL + TAQ E L Q+ Sbjct: 506 RADIIDKLFNMNALEVRDGKIKVTSKGKQILELAP---SELTSPLLTAQWEEKLTQIEKG 562 Query: 557 EAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVF 616 K +D FT+ + + K E+ N LT+ +CPTCG+ M G Sbjct: 563 RYNSKKFMDE-MKHFTKDIVQKIKSSEQKYKHDN---LTTTECPTCGKFMIKVKTKNGQM 618 Query: 617 LGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDP 676 L C P + K I N + A RC CG + +D Sbjct: 619 LVC----QDPSCKTKKNIQRKTNARCPNCKKKMTLFGRGKEAVYRC-VCGHSETQAQMDK 673 Query: 677 KRK 679 + K Sbjct: 674 RMK 676 Score = 46.6 bits (109), Expect = 0.004, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 25/80 (31%), Gaps = 13/80 (16%) Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 +I+ E + K + EC CG M + G+ + C + CK + I R Sbjct: 583 KIKSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPSCKTKKNIQRK------- 635 Query: 753 EDPVPLPELPCEKSDAYFVL 772 C L Sbjct: 636 ------TNARCPNCKKKMTL 649 >UniRef50_Q9HM08 DNA topoisomerase 1 n=4 Tax=Thermoplasmatales RepID=TOP1_THEAC Length = 770 Score = 473 bits (1218), Expect = e-131, Method: Composition-based stats. Identities = 164/796 (20%), Positives = 293/796 (36%), Gaps = 77/796 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G ++I E + I +L V L + +K S + Sbjct: 3 GFRIIIAEKADAGRRIAYFLSGGQVKSHRAKGTSYLEFEYNGSKTYLIPLSGHIVEA--- 59 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 D + +D +A + L+ K + I +ATD DREGE I Sbjct: 60 DFESGYSDWNKIDLSDLIDARIVKNIKNKVAYQTLQAFRGKVEEIVIATDYDREGELIGV 119 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 ++I R F+ +TKN I +F +N +A AR +D + G +++ Sbjct: 120 EALDIIKEGKEEIRRAKFSALTKNEILDSFKNLIGVNYSLADAADARESIDLIWGSVLTR 179 Query: 182 LLWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 R LSAGRVQ+ + +VV+REREI++F PE +W + + Sbjct: 180 FFSVTTGRLGKSFLSAGRVQTPTLAIVVDREREIQSFRPERYWTISITFDKDGQ------ 233 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + P +++ + ++ V K + APF T+ + AS R+ Sbjct: 234 --FKARYPENIKDQDTAEKIYEAIKGKNGRVSSYTSKEDHIRRPAPFSTTEFLREAS-RI 290 Query: 298 GFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-VNMVRGYISDNFGKKYLPE----SP 352 G K M +A+ LY G I+Y RTD+T + + V + + KY+ E Sbjct: 291 GIMPTKAMSIAENLYMRGLISYPRTDNTVYPRSINLKSVLKKLENTAYSKYVKEIETFDR 350 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 + H I P D + ++ D ++Y LI R F++ K Sbjct: 351 ILPSRGRIETTDHPPIYPVDSPK-----EQLKGDYGRVYDLILRHFLSTLYRDGKKTVAE 405 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 + + KA G+ GWT++ K D LP + +G+ L ++ + TK Sbjct: 406 AEIYVNGYTFKAAGQHTTDRGWTEIYGYDPK---DVYLPELTEGEDLKAIDWNIQREETK 462 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PP R+ +SL+K++E+ +G ST II + +RG++ E +G D + Sbjct: 463 PPPRYDMSSLLKKMEELNLGTKSTRHDIIGKLIERGFI--EGNPVKPTPLGMAFIDAVRS 520 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 + + + TA++E +D++ +E V++ + L + + Sbjct: 521 VNSHIADPEMTAKLEEDMDRIEKNEMSKNDVVEESKKMLHEVLSHFLTKTADVKDIITKG 580 Query: 593 VLTSIDCPTC----GRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 + + C G+K+ + + C CK + + Sbjct: 581 INAGQEIGDCPFHEGKKIMVIRDRFTYTVRCE------DPSCKINFRIKRNGSIT----- 629 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 + ++CP CG M +I + + +P C E Sbjct: 630 --------LSDQKCPVCGLPMIK-IIRKGQSPEIKCIDPDCSYNRENEDY---------- 670 Query: 709 VECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKS 766 EC + L+ ++GK ++ C+N +C T + + G + E C Sbjct: 671 GECPADHGRLVLRQSKYGKRFLGCSNYPKCTVTYPLPQMGRITKTGE--------VCPYC 722 Query: 767 DAYF--VLRDGAAGVF 780 A + R+G F Sbjct: 723 GAPILALSRNGRKWKF 738 >UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermophilum RepID=Q67NT6_SYMTH Length = 783 Score = 472 bits (1215), Expect = e-131, Method: Composition-based stats. Identities = 156/656 (23%), Positives = 266/656 (40%), Gaps = 79/656 (12%) Query: 2 GKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADS 50 GK L+I E P+ A I + LG ++Y++ ++GH+ +L Sbjct: 3 GKPLIIAEKPSAAMAIAQALGGFQRRDGYLESAEYLLSWAIGHLVEL------------- 49 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLAT 110 P+ + M P VLP L +L ++A + A Sbjct: 50 ------LPPEAYDPRWKRWTMETLPILPEGFGLHVLPKTRSQFRTLARLGKQAPLLVNAC 103 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQAR 168 D REGE I ++ G + R+ + +T AIR AF KP E + + R Sbjct: 104 DAGREGELIFRYICAAAGLE-KPVMRLWVSALTPAAIRAAFAEMKPQEHYDRLYRSARCR 162 Query: 169 RFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D +VG + K LSAGRVQ+ + +VV REREI++F PE +WEV A+ T Sbjct: 163 AEGDWLVGINATRAFTVKFGELLSAGRVQTPTLAMVVRREREIESFRPEPYWEVFAAFRT 222 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 P G + + R + + +A V + + V +++P +P F ++ Sbjct: 223 PDGREYTGKWFGPDGD--RLSSADAAEAVVRRVRRQAGWVEASDERPVAERPPQLFDLTS 280 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LQ+ A+ R G T+ AQ LYEA +ITY RTDS LS+ V + + + L Sbjct: 281 LQREANRRYGLTAAATLKAAQALYEAKHITYPRTDSRYLSRALVPQLPALVRALSARSDL 340 Query: 349 PESP-----------NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 N+ + H AI P+ E + + K+Y LI R+ Sbjct: 341 AALAAGADLSRVGFGNRRVVDDAKVTDHHAILPTS-----EVPRSLTGAEAKIYDLIVRR 395 Query: 398 FVACQMTPAKYDSTTLTVGAGDF--RLKARGRILRFDGWTKVMPALRKGDED-------- 447 F+A A++ + G+ R ++RGR L GW +V P + Sbjct: 396 FLAQFYPDARFLEQEVVTCVGELPDRFRSRGRRLVDPGWRQVEPEPARKRRAAEDEEEEG 455 Query: 448 -RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRG 490 ++LP + G+ + + ++ + T+PP R++EA+L+ +E G Sbjct: 456 LQLLPPLRMGEPVAVGDVESREKATRPPRRYTEATLLSAMEYAGREITDEALREAMKGHG 515 Query: 491 IGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE-LMNYDFTAQMENS 549 +G P+T A+II +++ GY+ E R G + + E E L++ + T + E+ Sbjct: 516 LGTPATRAAIIERLKEMGYIITERRSLVPTAKGRRLVELAERAGVEVLLSPELTGEWEHR 575 Query: 550 LDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK 605 + + + E + + + +++ G T+ P Sbjct: 576 IAGIQSGEYDDARFMQEIRELTARLVERIRATEGAPGRGGAGRSSTAEPGPAKEEP 631 >UniRef50_Q9NG98 DNA topoisomerase 3-alpha n=10 Tax=Eukaryota RepID=TOP3A_DROME Length = 1250 Score = 471 bits (1211), Expect = e-131, Method: Composition-based stats. Identities = 154/735 (20%), Positives = 277/735 (37%), Gaps = 91/735 (12%) Query: 3 KALVIVESPAKAKTINKYLGSD-------YVVKSSVGHIRDL--PTSGSAAKKSADSTST 53 K L + E AKTI L + Y V + D P G AK S S Sbjct: 27 KYLNVAEKNDAAKTIAGLLSNGAAQRREGYSV---YNKVFDFEAPVRGQNAKMVMTSVSG 83 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYE--VLPGKEKVVSELKQLAEKADHIYLATD 111 + + N VDP ++A + V E + L++ + + TD Sbjct: 84 HMMQLAFQVSYK---NWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTD 140 Query: 112 LDREGEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARR 169 DREGE I + + +V R F+EIT A+R+A + G+ + + +A R Sbjct: 141 CDREGENIGYEIIDVCRAIKPNISVYRATFSEITTVAVRRALQQLGQPDKRQSDAVDVRT 200 Query: 170 FMDRVVGYMVSPLLWKKIARG---------LSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 +D G ++ ++ R +S G Q + V ER +EI+AFV E FW Sbjct: 201 ELDLRTGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPTLGFVAERYKEIEAFVSEPFW 260 Query: 221 EVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 ++ T L ++ ++ F E R V KP Sbjct: 261 KIKVLHTIDD---LTVEFNWARNRLFDKEACENYLLLCLAEPDPRALVESVTVKPKHKWR 317 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGY 338 P T +++ S +L K+TM +A++LY G+I+Y RT++ S++ +V Sbjct: 318 PTPLDTVEMEKLGSRKLKLSAKETMTIAEKLYTKGFISYPRTETNQFSKEFALAPLVEMQ 377 Query: 339 I----SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 F ++ + PN + S +AH I P+ + ++++ + ++Y+L+ Sbjct: 378 TGHRDWGAFAQRVIEWGPN-PRNGNKSDQAHPPIHPTKLA------ENLQGNEARVYELV 430 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVN 454 R F+AC A T + + + A G ++ + V + + + Sbjct: 431 VRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNYLDVYVYDKWSA--KQIHHYE 488 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-E 513 G E++ + T P +EA L+ +EK GIG +T+A I+TI++RGY+ V + Sbjct: 489 NGQRFEPTEVSLHEGATTAPPLLTEADLIALMEKHGIGTDATHAEHINTIKERGYIGVLD 548 Query: 514 NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ 573 +G + + + L A+ E L + + + K VL + + Q Sbjct: 549 KGFLVPGVIGMGLYEGYDAMELALAKPQLRAEFELDLKLICQGQKDPKVVLTEQIAKYKQ 608 Query: 574 QLDK------------------------AEKDPEEGGMRPNQMVLTSIDCPTCGR-KMGI 608 + A ++ +G + ++ + CP C + + Sbjct: 609 AYQQITDKITAMDAKISARINETPAANSAVQEGADGSAPSHGIIQSIFQCPKCNEAPLAL 668 Query: 609 RTAST--GVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 + G ++GC+ + CK + L E + +VL+ CP CG Sbjct: 669 KPKKNQQGWYIGCNNFP-----DCKNAVWLPTECKDASVLD------------ECCPTCG 711 Query: 667 TAMDSYLIDPKRKLH 681 + Sbjct: 712 DGYRMLKFRLSTPYY 726 >UniRef50_C3QFV7 DNA topoisomerase III n=28 Tax=Bacteroidales RepID=C3QFV7_9BACE Length = 725 Score = 470 bits (1210), Expect = e-131, Method: Composition-based stats. Identities = 150/744 (20%), Positives = 263/744 (35%), Gaps = 91/744 (12%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 + I E P+ A+ I + LG + Y V + GH+ L + Sbjct: 2 IVCIAEKPSVARDIAEVLGAHTRKEGYIEGNGYQVTWTFGHLCTLKEPHEYTPNWKSWSL 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P + + +G D PG EK ++ L + AD I D Sbjct: 62 SSLPMIPPRF----GIKLIGHD------------PGIEKQFHVIEWLMQNADEIINCGDA 105 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 +EGE I + + G R+ + +T+ AIR+ F+K + A +R Sbjct: 106 GQEGELIQRWVMQKAGAR-CPVKRLWISSLTEEAIREGFSKLKDQAEFQSLYEAGLSRAM 164 Query: 171 MDRVVGYMVSPLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD---- 223 D ++G + L K + LS GRVQ+ + L+V R+ EI F P+++WE+ Sbjct: 165 GDWLLGMNATRLYTLKYGQNKQVLSIGRVQTPTLALIVNRQLEIANFEPKQYWELKTNYR 224 Query: 224 -----ASTTTPSGEALALQVTHQNDKPFR------PVNKEQTQAAVSLLEKARYSVLERE 272 A E A + + K N+E+ +A V ++ + V Sbjct: 225 NTTFSALIRKSDEEIAAEEEKNGGKKKIDNPGIDPIANREEGEALVERIKDLPFVVTNVG 284 Query: 273 DKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV 332 K F ++LQ + + + +T+ + Q LYE TY R D+T LS D Sbjct: 285 KKDGKEYAPRLFDLTSLQVECNKKFAYSADETLKLIQSLYEKKVATYPRVDTTFLSDDIY 344 Query: 333 NMVRGYISDNFGKKYLPE-------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEA 385 + + L ++ + H AI P+ V ++ Sbjct: 345 PKCPAILKGLRDYEVLTAPLAGTTLLKSKKVFDNSKVTDHHAIIPTGVYAQ-----NLTD 399 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG- 444 +++Y LI R+F+A K +TT+ + G+ + GW V K Sbjct: 400 MERRVYDLIARRFIAVFYPDCKISTTTVMGEVDKIEFRVTGKQILEPGWRVVFAKEVKDP 459 Query: 445 ------DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------- 487 +++ +LPA KG++ + + +T+PP ++EA+L++ +E Sbjct: 460 TEEKEEEDENVLPAFVKGESGPHI-PDLNEKWTQPPRPYTEATLLRAMETAGKLVDNDEL 518 Query: 488 -----KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDF 542 + GIGRPST A+II T+ R Y+R E + A G + + E L + + Sbjct: 519 RDALKENGIGRPSTRAAIIETLFKRNYIRKERKNLIATPTGVELVQLIHEEL--LKSAEL 576 Query: 543 TAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTC 602 T E L ++ + + L+ ++ + D + V + Sbjct: 577 TGIWEKKLREIEKKTYDARQFLEELKQMVSEIVMSVLSDNTNRRITIQDAVAAKAEEKEK 636 Query: 603 GRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRC 662 + A KT P + A + C Sbjct: 637 KEPKKRERKPSTPKEK-KPKAEKTTNEVKTDSPGSPAPVAMAASTPSTAGEVDAFVGQPC 695 Query: 663 PKCGTAMDSYLIDPKRKLHVCGNN 686 P CG + + C Sbjct: 696 PLCGKGTII----KGKTAYGCSEW 715 >UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIS7_9BACT Length = 867 Score = 470 bits (1209), Expect = e-130, Method: Composition-based stats. Identities = 178/815 (21%), Positives = 301/815 (36%), Gaps = 158/815 (19%) Query: 1 MGKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSAD 49 MGK LVI E P+ A+ I + LG ++VV S+VGH+ +L + Sbjct: 1 MGKTLVITEKPSVARDITRALGGFQNEKNFFEGPEHVVTSAVGHMLELVAPDGVEVQRGK 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQL--AEKADHIY 107 + V P H + + E + +K+L + D + Sbjct: 61 WALV----------------NLPVIPDH---FDLKPIQQNESQLKLIKKLYARKDIDSVI 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELN--IDRVNAQ 165 A D REGE I +L G R+ +T AIR F + + + A Sbjct: 102 NACDAGREGELIFHYLIRHFKGS-KPVRRLWLQSMTPQAIRDGFERLRDGETLLPLQRAA 160 Query: 166 QARRFMDRVVGYMVSPLLW--KKIARGLS---AGRVQSVAVRLVVEREREIKAFVPEEFW 220 R D ++G + + G S GRVQ+ + L+V+RE+EI+ F P E+W Sbjct: 161 VCRSESDWLIGINATRAMTALNSSGGGFSLTTVGRVQTPTLALLVDREKEIQHFEPREYW 220 Query: 221 EVDASTTTPSGEALALQVT-------------------HQNDKPFRPVNKEQTQAAVSLL 261 EV A SG V H KP R +K + +A V+ Sbjct: 221 EVKAIFAIASGRYEGYWVDPQLQPRSKQGVTPGAAKDQHGTAKPERIWDKTRAEAIVAQC 280 Query: 262 EKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYM 320 V E KP++ +P F ++LQ+ A+ R GF K T+ +AQ LYE + TY Sbjct: 281 ANREGRVSE-TTKPSSQQPPMLFDLTSLQREANRRFGFSAKTTLGIAQALYERHKVLTYP 339 Query: 321 RTDSTNLSQDAVNMV----RGYISDNFG----------------------KKYLPESPNQ 354 RTDS L +D V + +S G +++ N+ Sbjct: 340 RTDSRTLPEDYPKTVGTIMQSLVSSAAGPGAASSDAEGDRPISHWAERVLQEHYINGKNR 399 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLT 414 H AI P+ E+ ++ +++Y+L+ R F+A PA++++T Sbjct: 400 RIFNNAQVSDHFAIIPTG-----EAPGKLKEQERRIYELVTRCFIAAFYPPARFENTVRR 454 Query: 415 VGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAV-----NKGDALTLVELTPAQH 469 + RGR+L GW +VM + + + LP + + + VE+ Sbjct: 455 TVVEHQTFETRGRVLIESGWLQVMG---RKESNETLPPLASTAQDDSERAETVEIDLEGK 511 Query: 470 FTKPPARFSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVE 513 TK P R++EA+L+ +E RG+G P+T A+II + Y+ + Sbjct: 512 QTKAPPRYNEATLLSAMEGAGKLMEDDELREALQGRGLGTPATRAAIIEELIRNRYILRD 571 Query: 514 NRRFYAE-KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 R K ++ EL + T + E L Q+ + + + + H Sbjct: 572 ARELIPTAKATTLLRLLRALKIDELTTAELTGEWEKKLKQIESDQFSSEEFMRHIRRMTA 631 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC------------- 619 ++ A + + ++ + ++ CP CG+ V C Sbjct: 632 DIVEAARQ--CDVDQIDDEYAVLAVPCPKCGQGRVRENYRKFVCESCDFSIWKSIAGREL 689 Query: 620 -----------------SGYALPPKERCKTTINLVPE----NEVLNVLEGEDAETNALRA 658 +G+ + + + + +G+D + Sbjct: 690 SPNEVSSLLRDRRLGPLNGFRSRLGREFAAELMIKDDFTAAFDFGESTKGDDVDPQTCDQ 749 Query: 659 KRRCPKCGTAMDSYLIDPKRKL--HVCGNNPTCDG 691 CPKCG + L P+R + + G+ P CD Sbjct: 750 VGPCPKCGAPV---LDAPRRYVCRNGLGDEPACDF 781 >UniRef50_C9LK04 DNA topoisomerase III n=3 Tax=Prevotella RepID=C9LK04_9BACT Length = 705 Score = 469 bits (1208), Expect = e-130, Method: Composition-based stats. Identities = 143/651 (21%), Positives = 249/651 (38%), Gaps = 84/651 (12%) Query: 6 VIVESPAKAKTINKYLG---------------------SDYVVKSSVGHIRDLPTSGSAA 44 +I E P+ A+ I + +G SDYVV ++GH+ L + Sbjct: 5 IIAEKPSVARDIARIVGASNKQEGYLASTPSADFQLEGSDYVVTWAMGHLIALAMPEAYG 64 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD 104 + P + + + Y P K + ++ +KAD Sbjct: 65 FSAYKREDLPIRPNPFQLVVRQVRK----------DKEYHDDPAALKQLKVIRSCFDKAD 114 Query: 105 HIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRV 162 I +ATD REGE I ++ + + + R+ + +T AIR+ + PG + Sbjct: 115 RIIVATDAGREGELIFRYIYQHLNCC-KPFERLWISSLTDKAIREGLSNLKPGSSYDNLY 173 Query: 163 NAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 + +AR D +VG S L G S GRVQ+ + +V R + F +W++ Sbjct: 174 YSAKARSEADWLVGINASRALSIARKGGYSLGRVQTPTLAMVCRRYIANRDFSSVPYWKL 233 Query: 223 DASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKA-RYSVLEREDKPTTSKPG 281 T E L+L+ D ++ Q A++ L R +V K T + P Sbjct: 234 SVHTEK---EGLSLKAIGSED----YESEASAQTALATLRSQSRLTVESVARKVTHTAPP 286 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 + + LQ+ A+ R GF KT+ +AQ LYE TY RT S +S+D V + Sbjct: 287 LLYDLTALQKDANRRHGFSADKTLSIAQSLYEKKITTYPRTGSRYISEDVFEEVPALLRK 346 Query: 342 NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 K L N ++ H AI P+ E + D +Y ++ +F Sbjct: 347 I--GKTLSNPLNIHSVDNAKVTDHHAIIPTG-----EMPTGLSTDEANIYNMVVTRFAEA 399 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKV--------MPALRKGDED---RIL 450 ++ + + G + GW V ++ D++ L Sbjct: 400 FSPDSEEERMQVRFTDGTNIFTWKACRQISLGWKAVQKELVTDAEKKEKENDDELVLPSL 459 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRP 494 P + +G+ L+LV H TKP ++EA+L+ +E + GIG P Sbjct: 460 PDLTEGEVLSLVSAEITAHKTKPKPLYTEATLLSAMENAGKEVKEDDKRKAMAECGIGTP 519 Query: 495 STYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 +T A+II T+ R Y+R + + + G V + +++ +++ N + T E +L + Sbjct: 520 ATRANIIETLILRDYIRRDKKAIIPTEKGLAVYEIVKD--KKIANAEMTGSWELALAAIE 577 Query: 555 NHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK 605 + + S ++ E P CP CG++ Sbjct: 578 AGKMPSERFAQGINSYVGTICEELLSLSSEQKSYP------VYRCPKCGQQ 622 >UniRef50_Q46AN3 DNA topoisomerase n=3 Tax=Methanosarcina RepID=Q46AN3_METBF Length = 855 Score = 469 bits (1208), Expect = e-130, Method: Composition-based stats. Identities = 175/810 (21%), Positives = 319/810 (39%), Gaps = 80/810 (9%) Query: 8 VESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGAL 67 E A I LG V + + + LP K + D Sbjct: 7 AEKNKAASQIASILGEGEVERIT---VEGLPVYEFKWKGEEWLVMGLSGHIMNYDFPEQY 63 Query: 68 VNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVI 127 V+P E + L + + +K LA++A+ I LA D DREGE I + + + Sbjct: 64 NKWKEVNPGVLLEIDPQKLVTRTDYAAAVKNLAKRANKIVLACDYDREGENIGFEAKTLA 123 Query: 128 -GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKK 186 + R F+ ++ +++AF + + A +AR+ +D +G + + Sbjct: 124 EKVTNVPIERARFSSLSPKEVKKAFESLINPDYNMAMAAEARQILDLKMGAAFTRFVTLS 183 Query: 187 IARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 + LS G Q+ V ERE+ I+AF ++FW++ A + SG+ + Sbjct: 184 VRERARTKDILSIGPCQTPTCGFVYEREKAIRAFQAKDFWKITAIFSAESGKEGGKEGRK 243 Query: 241 QNDKPFRPV--------------NKEQTQAAVSLLEKARYS-VLEREDKPTTSKPGAPFI 285 + K + +KE+ L+ + V ++ K T + P P Sbjct: 244 EGRKEGKKERGDFEGTHRAGNIHDKEKAAEIFKRLKGTKEGLVAKKTVKETKTSPPNPLN 303 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA------VNMVRGYI 339 T+ + AS LG + + +A++LY AG+ +Y RT++ ++D + R Sbjct: 304 TTEFLKRASKFLGISPELALEVAEQLYLAGFTSYPRTETNKYAEDFDFKSLVFDFARQKE 363 Query: 340 SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQLIWRQF 398 F + L +P + E H I P E + ++Y LI R F Sbjct: 364 YKPFAESILI-APIVPKNGEKDAHDHPPIHPIRAASRGEVSSAVNIPQAPEVYNLIARHF 422 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 +A M A ++ T L + + + G +L+ GW + P K D ++LP V +G Sbjct: 423 LANLMPAAVFEKTHLHLLVNEEPFDSSGTVLKDSGWLEAYPFENKKD--KLLPFVEEGQK 480 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFY 518 + + +L+ + T PP + +EA L+ ++K GIG +T + I T + RGY+ + + Sbjct: 481 VGVKKLSNTKSKTSPPKKLTEAELLTLMDKNGIGTKATAPTHIETNKKRGYLETKGKTIS 540 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 G + D L L+ + A++E + +V + + E++A L + + + Sbjct: 541 ILDTGFTLMDGLSLTVPILVKPEIRAKIEALIQEVEDGKKEFEAALYEGTTLIKEMYAQL 600 Query: 579 EKDPEEGGMRPNQMVLTS----------IDCPTCGRKMGIRTASTGVFLGCSGYALPPKE 628 E + +E + C CG + I +G F+GC+GY Sbjct: 601 EANKKELTSSIAGTIKDEAALEDKKNYIGTCKACGHVLRIVQTDSGRFVGCTGYP----- 655 Query: 629 RCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPT 688 C+ + L P+ L VL ++ C K G A+ L + G P Sbjct: 656 DCRNSYPL-PKAGALTVLRSKE-----------CKKGGVAV---LKVGNKYNWAVGIGP- 699 Query: 689 CDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEV 748 C ++E+ + + C +C M L + +++ CT + C T + + G++ Sbjct: 700 CFTCDLEKECYP----PETVGPCPECDGSMFLINFKDTRFLGCT-KRCGYTHSVPKTGKL 754 Query: 749 APPKEDPVPLPELPCEKSD-AYFVLRDGAA 777 + + CE F L+DG Sbjct: 755 T--------ILDKTCETCGWKLFRLKDGDR 776 >UniRef50_A5ZSZ0 DNA topoisomerase n=12 Tax=Bacteria RepID=A5ZSZ0_9FIRM Length = 703 Score = 469 bits (1207), Expect = e-130, Method: Composition-based stats. Identities = 147/662 (22%), Positives = 254/662 (38%), Gaps = 85/662 (12%) Query: 5 LVIVESPAKAKTINKYLG-----SDY------VVKSSVGHIRDLPTSGSAAKKSADSTST 53 LVI E P+ ++ I + +G Y +V GH+ + + + +K Sbjct: 3 LVIAEKPSVSRAIAEVIGAQEREDGYLQGTDCMVSWCFGHLAEYVSPDAYDEKFNQWRYE 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAE--KADHIYLATD 111 PK + V K+ LK+L + +++ A D Sbjct: 63 DLPIIPK-------------------DWKVTVSEDKKDQFYILKRLLNSPEIEYVVNACD 103 Query: 112 LDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQQARR 169 REGE I H+ + + G R+ + + +AI E A R Sbjct: 104 AGREGELIFKHVYD-LSGSKKPVKRLWISSLEDSAILDGMQHLRSAEEYRHLAEAAVCRS 162 Query: 170 FMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 D +VG + K + L+ GRVQ+ + ++VER +I F E+++ V+ Sbjct: 163 QADWLVGMNATRAYTTKYFKKLTVGRVQTPTLAMLVERAGQISNFQKEKYFNVELDCDGI 222 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTL 289 + + ++ + S + + V ++ K + +TL Sbjct: 223 PAV------------KPKIFDPDEAEQLRSRCQGSEAIVTAVKETEKKVKAPKLYDLTTL 270 Query: 290 QQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL- 348 Q+ A+ G K+T+ AQ LYE ITY RTDS L++D R + + K L Sbjct: 271 QREANRIYGMTAKQTLDTAQSLYEKKLITYPRTDSQYLTEDMEQTARNVVRQIYEKYQLT 330 Query: 349 -----PESPNQYASKENSQ-EAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQ 402 PE P+ NS+ H AI P+ + + + L ++++ +K+ LI V Sbjct: 331 GPFDQPEQPDVKKVMNNSKVTDHHAIIPT-MELASCHLDELKSWEEKILFLIAVHTVMAM 389 Query: 403 MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE----------DRILPA 452 Y T + V + KA+G+I+ DGW + D +P Sbjct: 390 SKDHIYQETEIEVECQEEIFKAKGKIVLQDGWKLFENCFKNKDRMAIVDPDQEMKERMPK 449 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------EKRGIGRPSTYASI 500 V +G V+ +HFT PP +SE +L+ + EK+G+G P+T A I Sbjct: 450 VTQGQTFYAVDAEKTEHFTSPPKPYSEDTLLAAMETAGNKEFDEDTEKKGLGTPATRAGI 509 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 I + Y + ++ G+++ + L + L + TA+ EN L + + E Sbjct: 510 IEKLVYSQYATRKGKQIIPTDDGKVLVEILPDF---LKSASMTAEWENQLLLMEHGEIAP 566 Query: 561 KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCS 620 + + + T L+ + EE R Q + CP CG + S F CS Sbjct: 567 EQFMTGIKNMLTMMLNGCDAISEEETRR-FQTRESIGTCPVCGS---LVYESKTNFY-CS 621 Query: 621 GY 622 + Sbjct: 622 NH 623 >UniRef50_Q5WAX6 DNA topoisomerase 3 n=137 Tax=Bacteria RepID=TOP3_BACSK Length = 729 Score = 469 bits (1207), Expect = e-130, Method: Composition-based stats. Identities = 157/726 (21%), Positives = 272/726 (37%), Gaps = 105/726 (14%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M K V+ E P+ A+ I + LG + Y++ ++GH+ K+ Sbjct: 1 MKKKAVLAEKPSVARDIARVLGCNQKGNGYLEGNGYIITWALGHLVTHADPEHYGKQYKT 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIY 107 + PK+ V+ K +K + + D + Sbjct: 61 WKLEELPMLPKR-------------------LELVVIKQTAKQFHAVKHVLNRQDVGEVV 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQ 165 +ATD REGE +A + E R+ + +T AI+ F + G+ A Sbjct: 102 IATDAGREGELVARWILEKAHV-KKPVKRLWISSVTDKAIKDGFKQLKDGKRYETLYAAA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D VG + L K LS GRVQ+ + ++ +RE I+ FVP+ + + Sbjct: 161 AARAEADWYVGINGTRALTTKHNAQLSCGRVQTPTLAILADREEAIRKFVPKPYHTISVE 220 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 T + + + + K R + ++ + L+++ + K + P + Sbjct: 221 TK----DGVTFRWADRRSKEERIFDDKRAKTLQEKLQQSAIVIDSVNAKTKRTPPPPLYD 276 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYI----- 339 + LQ+ A+ R G+ K+T+ QRLYE +TY RTDS LS D V ++ + Sbjct: 277 LTELQREANKRFGYSAKETLAALQRLYEQHKAVTYPRTDSRYLSSDLVETLKERLHAVDV 336 Query: 340 ------SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 N K+ L + Q + + H A+ P++ +S M KLY L Sbjct: 337 QPFRKMVANAKKQGLANAKRQMVNDAKVSD-HHALIPTE---QPQSASAMSDKEAKLYHL 392 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAV 453 I R+F+A P++ + T++ A L+A+G L GW R+LPA+ Sbjct: 393 IVRRFLANFFPPSESELTSVEATANGELLRAKGERLVSAGWRGQETGEEDEALARLLPAM 452 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEK-------------------RGIGRP 494 +KGD + + Q T PP RF+E +L+ +EK GIG Sbjct: 453 SKGDKKAVKWVGMTQGKTSPPPRFNEGTLLAAMEKPAQHMEAKDETIKKTLAQAGGIGTV 512 Query: 495 STYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 +T A II + Y+ + + Y G+ + + + EL + TA+ E L+++ Sbjct: 513 ATRADIIEKLFSSFYIEKKGKDLYITSKGKQLLELVPA---ELKSPALTAEWEQRLEKIV 569 Query: 555 NHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG 614 + + + + + + + D T CP CG+ + G Sbjct: 570 QGKEQKQMFIAEMKEYAKAVVAQVKAD----TATFRHDNKTGEKCPECGKFLLEVNGKKG 625 Query: 615 VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLI 674 C C N+ A+ RCPKC ++ Sbjct: 626 KMRVC------QDRECGYRKNI------------------AMTTNARCPKCKKKLELRGE 661 Query: 675 DPKRKL 680 + Sbjct: 662 GEGQVF 667 Score = 51.6 bits (122), Expect = 1e-04, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 27/91 (29%), Gaps = 13/91 (14%) Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 +++ + + +C +CG + G+ GK C + EC + I Sbjct: 592 QVKADTATFRHDNKTGEKCPECGKFLLEVNGKKGKMRVCQDRECGYRKNI---------- 641 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAA 783 C K LR G A Sbjct: 642 ---AMTTNARCPKCKKKLELRGEGEGQVFAC 669 >UniRef50_A4JW73 DNA topoisomerase n=1 Tax=Burkholderia vietnamiensis G4 RepID=A4JW73_BURVG Length = 823 Score = 469 bits (1206), Expect = e-130, Method: Composition-based stats. Identities = 168/696 (24%), Positives = 266/696 (38%), Gaps = 108/696 (15%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 MGKAL++ E P+ A I K LG D +V + GH+ + Sbjct: 1 MGKALIVAEKPSVAADIAKALGGFTKADGYFERDDAIVAPARGHLVE------------- 47 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIY 107 P D +G + ++GV P EV+ G S LK+L + D + Sbjct: 48 ------QTVPAADAKG--MWKIGVLPIIPDSFELEVIDGCTAEFSRLKKLMARDDVASVV 99 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQ 165 A D REGE I + G R+ + +AIR+A + +PG +A Sbjct: 100 NACDAGREGELIFRLIYNKAGCR-KPTKRMWIQSMVASAIRKAHDDLRPGAEFDHLSDAA 158 Query: 166 QARRFMDRVVGYMVSPLLW-----KKIARGLS-AGRVQSVAVRLVVEREREIKAFVPEEF 219 R D +VG + K R +S GRVQ+ + + V REREI AFV ++ Sbjct: 159 FCRSEADWIVGVNGTRATTALRERKTQRREVSPVGRVQTPTLAMPVIREREIAAFVARDY 218 Query: 220 WEVDASTTTPSGEALALQVTHQNDKP-----------------FRPVNKEQTQAAVSLLE 262 WE+ + +G +A + + R +K + QA V + Sbjct: 219 WEIHGTFRAEAGTYVAKWIGDADGDTSPAETEGDAEAEAEQTGARCFDKAKAQAIVDKCK 278 Query: 263 KARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMR 321 S + E KP A F + LQ+ A+ R F KKT+ +AQ LYE TY R Sbjct: 279 GVDPSSVVDESKPEERPAPALFDLTALQREANKRFKFSAKKTLDIAQALYEKHKATTYPR 338 Query: 322 TDSTNLSQDAVNMVRGYIS-------DNFGKKYLPE---SPNQYASKENSQEAHEAIRPS 371 TDS L +D + ++ + ++ + P++ H AI P+ Sbjct: 339 TDSRALPEDYLETAAATLATFASTPLEAHAQRVIENGWVKPDKRIFNNADISDHFAIVPT 398 Query: 372 DVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRF 431 + + +D QK+Y L+ R+F+A AKY+ T T + G++L Sbjct: 399 G-----QQPDGLSSDEQKIYDLVSRRFIAVFHPSAKYEKTVRTTIVAGETFRTSGKVLVE 453 Query: 432 DGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK--- 488 GW V D L V G+A+T + TKPP R++EA+L+ +E Sbjct: 454 PGWLAVYGEKAHDDTAAALCKVADGEAVTADAIELKALQTKPPKRYTEATLLAAMENAGR 513 Query: 489 -------------RGIGRPSTYASIISTIQDRG---------YVRVENRRFYAEKMGEIV 526 GIGRP+T A+II + + Y+R ++ + Sbjct: 514 QVEDKDIRAAMKANGIGRPATRAAIIEGLLEDKDKNDNPKEPYLRRDDNELVPTPKAMEL 573 Query: 527 TDRLEENFRE-LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 LEE + L++ T + E L ++ + + T ++ E Sbjct: 574 IAFLEEAGIDFLVSPQMTGEWEQKLLRMEKGDYRRSTFMSEIADLSTGMVETIRAKYNEL 633 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG 621 + + CP CG + + G CSG Sbjct: 634 PEPVAKAL--DAPCPRCGAAVHV----DGRAYQCSG 663 >UniRef50_A1TJM5 DNA topoisomerase n=55 Tax=Proteobacteria RepID=A1TJM5_ACIAC Length = 680 Score = 468 bits (1205), Expect = e-130, Method: Composition-based stats. Identities = 165/694 (23%), Positives = 263/694 (37%), Gaps = 99/694 (14%) Query: 5 LVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 +V+ E P++ K I + LG+ V +GH+ + + + + Sbjct: 3 VVLCEKPSQGKDIARVLGARQREAGCLAGPGIKVTWGIGHLIEAAPPEAYGEHFQRWSLE 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 P+ + + V +++L +A + +ATD D Sbjct: 63 TLPIVPQ-------------------QWRWVVKADTASQFKVVQRLLAQASELIIATDAD 103 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRFM 171 REGE IA L E G R+ + + +IR+A + + AR Sbjct: 104 REGEMIARELIEYCG-YRGPIQRLWLSALNDASIRKALGALRASHETLPLYHCALARSHA 162 Query: 172 DRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D +VG ++ L + LS GRVQ+ ++LV +R+REI AFVP FW ++ S Sbjct: 163 DWLVGINLTRLFTLLGRKAGFDGVLSVGRVQTPTLKLVADRDREIAAFVPVPFWSIEVSL 222 Query: 227 TTPSGEALALQVTHQ--NDKPFRPVNKEQTQAAVSLLEKA-RYSVLEREDKPTTSKPGAP 283 + + A V D R + + Q A + + A V + + P P Sbjct: 223 SAGAQAFSAHWVPPATVTDAAGRCLQQSAAQHAAAAVRTAGHAQVTGIDTERVQEGPPLP 282 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGYISDN 342 F STLQ+ S RLG V++T+ +AQ LYE TY RTD+ L ++ + V I Sbjct: 283 FDLSTLQEVCSRRLGLDVQETLDIAQALYETHKATTYPRTDAGYLPENMLTEVPTVIRSL 342 Query: 343 FGKKY--------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 L A AH AI P+ + L M +Y+LI Sbjct: 343 LKTDPALQPLMQRLDLGQRSRAWNATKIAAHHAIIPT---LEPADLSKMSEKELAVYRLI 399 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------------PALR 442 ++A + YD T + + G L+A G+ + GW P Sbjct: 400 RAHYLAQFLPHYAYDRTMVRLACGGQALQASGKQVVDAGWKAAFAAPSIPGAGAETPEAE 459 Query: 443 KGDE---DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE------------ 487 E D+ LP +++G A + L +TK P +++ LVK ++ Sbjct: 460 TDSEAPRDQALPTLHEGMACEVRSLDLKSLYTKSPPPYTQGELVKAMKTVAKLVTDPRLK 519 Query: 488 -----KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDF 542 GIG +T A+IIS + RG++ + R A K + D + + + Sbjct: 520 QTLRDTTGIGTEATRANIISGLLARGFLVRKGRVVRASKTAMTLIDAVPAA---IADPGT 576 Query: 543 TAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTC 602 TA E +L + + LD F S + + + E + V CP C Sbjct: 577 TAIWEQALHMIEARTMD----LDTFVSKQAAWVSQLVEQHREATLAIR--VPAGPPCPLC 630 Query: 603 GRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 G RT TG F CS Y CK T+ + Sbjct: 631 GAATRKRTGKTGAFWSCSRYP-----DCKGTVAI 659 Score = 55.1 bits (131), Expect = 1e-05, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 20/57 (35%), Gaps = 4/57 (7%) Query: 760 ELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYR----FRDRLPEKLR 812 PC A R G G F + + +P + T A E R + R KL Sbjct: 624 GPPCPLCGAATRKRTGKTGAFWSCSRYPDCKGTVAIDSAEAGRRNGPRKPRAARKLH 680 >UniRef50_A1U3N5 DNA topoisomerase n=6 Tax=Gammaproteobacteria RepID=A1U3N5_MARAV Length = 722 Score = 468 bits (1205), Expect = e-130, Method: Composition-based stats. Identities = 167/751 (22%), Positives = 269/751 (35%), Gaps = 110/751 (14%) Query: 5 LVIVESPAKAKTINKYL------GSDYV----------VKSSVGHIRDLPTSGSAAKKSA 48 L I E P+ A+ I L G ++ V +GH+ + Sbjct: 3 LYIAEKPSLARAIAAALPGPHEKGQGWIRCGKGPDAATVSWCIGHLLE------------ 50 Query: 49 DSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYL 108 +P + R+ P L+ L KAD I Sbjct: 51 -------PAEPARYNPAWKKWRIEDLPMFPEPWQLTPKDSVRLQFKVLEALVRKADLITH 103 Query: 109 ATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQ 166 A D DREG+ + + +G A R++ N++T A+ +A P + ++ Sbjct: 104 AGDPDREGQLLVDEVLRYLG-TKAPVKRILINDLTPKAVARAIQNPRDNREFRPLSHSAL 162 Query: 167 ARRFMDRVVGYMVSPLLWKKI-----ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 AR+ D + G ++ S GRVQ+ + LVV+R+ I+ F P+ ++ Sbjct: 163 ARQRADWLYGINLTRFYTLSYQTRGEQGVFSVGRVQTPVLGLVVDRDNTIEHFQPKPWYR 222 Query: 222 VDASTTTPSGEAL----------ALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLER 271 V+A+ EA + D+ R ++K + V+ + + E Sbjct: 223 VEATFQASEPEADQRPFIARWLPGDEFQDHLDEENRLLDKSVAEQIVAAISGRPGRIDEA 282 Query: 272 EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQD 330 + P P S LQ A G K + AQ LYE ITY R+DS L ++ Sbjct: 283 RFRDRPEPPPLPLSLSALQIEAGRLYRMGAKDVLDTAQNLYERHQLITYPRSDSRYLPEE 342 Query: 331 AVNMVRGYIS---------DNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK 381 + I F +K E A + +AH AI P+ V Sbjct: 343 HFSQREAVIRAIARVAPDLSGFCEKTGTER-RSAAWNDQKVDAHHAIIPT---VRPAPNG 398 Query: 382 DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPAL 441 + + QK+Y LI R ++ A + LTV D+R +A + GW + Sbjct: 399 KLSSAEQKIYDLISRFYLMQFAPDAVHREGRLTVAIQDYRFRATETAVIEPGWKTLEIRK 458 Query: 442 RK---GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------ 486 R+ E LP + K + + + + T+PP F++A+L+ + Sbjct: 459 REPGQEPEKAPLPRLEKNEPVLCTDPQTNERKTQPPQHFTDATLLSAMTNIARFVADNEL 518 Query: 487 -----EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYD 541 E G+G +T A+II T+ R Y+ E R A G+ + L E + D Sbjct: 519 RKTLRETDGLGTEATRAAIIDTLFRRDYLFREKRFIRATDKGKSLIAALPE---SIRTPD 575 Query: 542 FTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPT 601 TA E +L+ V E + +A L+ + + +A G+ + T+I CP Sbjct: 576 RTAVWEATLEGVRRGEEDPRAFLESLKDEIRGFMAQAPA----AGLANTETPGTAIHCPK 631 Query: 602 CGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRR 661 C M R G F C+ Y CK T L E E + Sbjct: 632 CRAPMVEREGKFGAFFACTRYPA-----CKGTRPL----------EDHQPEDGTSQKPVP 676 Query: 662 CPKCGTAMDSYLIDPKRKLHVCGNNPTCDGY 692 CP C + + + C N P C Sbjct: 677 CPHCFSPLVRRKSNKG-WFWGCSNFPGCRQT 706 Score = 91.3 bits (225), Expect = 1e-16, Method: Composition-based stats. Identities = 27/101 (26%), Positives = 39/101 (38%), Gaps = 6/101 (5%) Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPP 751 + G + C KC + M + G+FG + ACT CK TR + + Sbjct: 611 QAPAAGLANTETPGTAIHCPKCRAPMVEREGKFGAFFACTRYPACKGTRPLEDHQPEDGT 670 Query: 752 KEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRET 792 + PVP C + V R G F + FP R+T Sbjct: 671 SQKPVP-----CPHCFSPLVRRKSNKGWFWGCSNFPGCRQT 706 Score = 61.3 bits (147), Expect = 2e-07, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 20/55 (36%) Query: 739 TRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETR 793 R + A P + C K A V R+G G F A +P + TR Sbjct: 605 IRGFMAQAPAAGLANTETPGTAIHCPKCRAPMVEREGKFGAFFACTRYPACKGTR 659 >UniRef50_A3DB61 DNA topoisomerase n=1 Tax=Shewanella baltica OS155 RepID=A3DB61_SHEB5 Length = 707 Score = 468 bits (1204), Expect = e-130, Method: Composition-based stats. Identities = 161/728 (22%), Positives = 274/728 (37%), Gaps = 94/728 (12%) Query: 5 LVIVESPAKAKTINKYLG----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTK 54 L + E P++AK I LG V VGH+ + Sbjct: 3 LFLCEKPSQAKDIASVLGCKRGDGVFTGDGIAVTFCVGHVLQQAEPENYNPDFETWNIVD 62 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 P W+ V P + + +K+ KA + +ATD DR Sbjct: 63 LPIIPTV-----------------WKML--VSPKTKAQFAIVKKQLAKATEVIIATDADR 103 Query: 115 EGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFMD 172 EGE IA + E + R+ + + +I++A +P +A R D Sbjct: 104 EGEVIAREVLEYV-NYKGPIQRLWLSALDDASIKKALASLRPNHETAKLYDAGLGRSRGD 162 Query: 173 RVVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 ++G ++ L S GRVQ+ +RLVV+R+ +++ F P+ ++++ Sbjct: 163 WLIGMNMTRLCTLLSREYGYQGAFSVGRVQTPTLRLVVDRDSQVEQFEPQSYYDITGLFN 222 Query: 228 TPSGEALALQVTHQ-NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFIT 286 QV D+ R + +S +V + + K SK F Sbjct: 223 ATIPFKAKWQVPDNLGDEQGRCLQVTTVDHVLSQCRDQPGTVTQFDTKRQKSKHPPLFFL 282 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYISD---- 341 +LQ+A S + G+G K+ + +AQ LYE + TY RTD L V + Sbjct: 283 GSLQKAMSAKFGYGAKEVLDIAQSLYEKYKVTTYPRTDCPYLPLSQKEEVGSILDKLKVV 342 Query: 342 -NFGKKYLPESPNQYA--SKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 F N+ + + AH I P + L +M LY I +++ Sbjct: 343 PAFAAWCSAADVNETSACWNDKKITAHHGIIP---LPVTPKLHEMNEKELNLYHAIVQRY 399 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG---DEDRILPAVNK 455 +A A+ D+TT+ + G +KA G++ R GW V + D+ LP ++ Sbjct: 400 LAQFYPVAEDDATTIELMVGSQSVKATGKVERVKGWRLVTGKDSEDETTDDSANLPLLSI 459 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYA 498 G LT + TKPP RF+E +L+ + E GIG +T A Sbjct: 460 GQTLT-AQFQREDKRTKPPGRFTEGTLIDAMSNIAKFESDPKLKSILKETSGIGTEATRA 518 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 +II T++ RG+V V ++ + + G + D L + L TA E +LD++A Sbjct: 519 NIIDTLKARGFVTVTGKQLISSEAGRSLIDALPDV---LTRPAMTALWEQALDEIALGNG 575 Query: 559 EWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG 618 + + TQ + ++ + ++ +++ ++ CP C + M + G F Sbjct: 576 SLDDFMARQSTFITQLVSMFKQG--QYTLKLPKVLAVTLPCPVCQKSMKQLSGKNGKFWV 633 Query: 619 CSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR 678 C KE+C +LN G+ +T C K G + + Sbjct: 634 C-----EDKEQCGL---------LLNDERGKLPKTTPC----TCKK-GVLVRKKAKTKGK 674 Query: 679 KLHVCGNN 686 C Sbjct: 675 FWWGCSAY 682 >UniRef50_A5FHK0 DNA topoisomerase III n=25 Tax=cellular organisms RepID=A5FHK0_FLAJ1 Length = 768 Score = 468 bits (1204), Expect = e-130, Method: Composition-based stats. Identities = 164/850 (19%), Positives = 290/850 (34%), Gaps = 137/850 (16%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 + I E P+ A+ I LG + Y V + GH+ L Sbjct: 2 KVCIAEKPSVAREIASVLGANTKHDGYYEGNGYAVTYTFGHLCTLKEPNDYKPHWKSWDL 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 P+K E + N G +K +K L +KA+ + D Sbjct: 62 NNLPMLPEKFETKVVQN-----------------SGIQKQFKIIKTLFDKAELVINCGDA 104 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRF 170 +EGE I + R+ + +T AI++ F+ P E + A +R Sbjct: 105 GQEGELIQRWVMNEAH-YKGEIKRLWISSLTTEAIKEGFDNLKPSENYDNLFYAGFSRAI 163 Query: 171 MDRVVGYMVSPLLWKK---IARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D ++G + L K + LS GRVQ+ + +VV+R +EI+ F P+ +WE+ Sbjct: 164 GDWLLGMNATRLYTVKHGGYKQVLSIGRVQTPTLAMVVDRFKEIENFKPQPYWELQTLYR 223 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 T + + R + KE + ++++ + ++ + K F + Sbjct: 224 E----------TLFSYEEGRFLKKEDGEILAEKVKESDFEIVSVDKKNGNEYAPKLFDLT 273 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD-----N 342 LQ + + GF ++T+ +AQ LYE ITY R D+T L D V G + + Sbjct: 274 GLQVYCNQKFGFSAEETLKIAQTLYEQKAITYPRVDTTFLPGDIYPKVPGILQKLTNYSH 333 Query: 343 FGKKYLPESPNQ--YASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 + L + + + H AI P+ + + ++ + Q++Y +I ++F+A Sbjct: 334 LTEPLLGKKIKKSPKVFNDKKVTDHHAIIPTGIEI------NLPYNQQQVYDIIVKRFLA 387 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR-KGDEDRILPAVNKGDAL 459 +TT+ A D KA G+ + G+ V K E +LP+ G+ Sbjct: 388 VFYDDCLVANTTVIGKAADVTFKATGKEILKKGFRVVFEDPNAKEKEPDLLPSFVVGEKG 447 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRPSTYASIIST 503 E + Q TKPP F+EA+L++ +E + GIGRPST A+II T Sbjct: 448 -PHEPSFLQKETKPPNHFTEATLLRAMETAGKQVDDEDLRELMKENGIGRPSTRANIIET 506 Query: 504 IQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 + R Y+ ++ G + D ++ + + + T E L + A Sbjct: 507 LFKRQYIVRNKKQVLPTTTGIQLIDTIQNEL--IKSAELTGSWEKQLKDIEKGTFTAAAF 564 Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYA 623 + + + + + + Sbjct: 565 IRNMKRMVEALVTEVRSETRHANISHA--------------------------------- 591 Query: 624 LPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVC 683 TI G AET CPKC + C Sbjct: 592 --------ATIQKPAVKAEKKKAAGILAET--------CPKCQKGNFI----KGKSAFGC 631 Query: 684 GNNPT-CDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRF--GKYMACTNEECKNTR 740 + CD + + +K GS +++K + G E Sbjct: 632 SEYKSGCDFVLPYGFHDKKITESQYLRLVQK-GSTVNIKGFKTDAGTVEGLIRFEENYKL 690 Query: 741 KILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 K+ L C K +L+ G + + + + E Sbjct: 691 KLEPKKTYIKKTTKETASDSLSCPKCKKGNILK-GKTA--YGCSEYKSGCDFKVTFDEVR 747 Query: 801 YRFRDRLPEK 810 + +D+ P K Sbjct: 748 AKLQDQKPTK 757 >UniRef50_C7H9Z3 DNA topoisomerase n=32 Tax=Firmicutes RepID=C7H9Z3_9FIRM Length = 707 Score = 467 bits (1201), Expect = e-130, Method: Composition-based stats. Identities = 132/674 (19%), Positives = 248/674 (36%), Gaps = 95/674 (14%) Query: 1 MGKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSAD 49 M LVI E P+ A++I +G+ Y+V +GH+ +G +K Sbjct: 1 MSFQLVIAEKPSVARSIAAVIGATEKQNGYWQGGGYLVSWCIGHLVSFAEAGQYDEKYCK 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK--ADHIY 107 P+ + V K++ ++ L + D + Sbjct: 61 WRYEDLPILPQP-------------------WQFIVPDEKKQQFEIVRSLLNRPDVDSVT 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQ 165 ATD REGE I + ++ G R+ + + AIR+ F + Sbjct: 102 AATDAGREGELIFRFVYQMAGC-TKPVKRLWISSMEDAAIREGFANLRPDSDYDALYQSA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 R D +VG + L + L+ GRVQ+ ++++V+R+ +I F E+++ V Sbjct: 161 LCRAKADWLVGINATRLFSVLYHKTLTVGRVQTPTLKMLVDRDAKILRFQKEKYYTVGIQ 220 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 + + ++ R + E A + + T +P + Sbjct: 221 SGSLKADSE------------RISDAEAANLLKEKCTGANAVCVSIRREKKTEQPPKLYD 268 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDN--- 342 +TLQ+ A+ GF K+T+ AQ+LYE +TY RTDS L++D + +SD Sbjct: 269 LTTLQREANRLFGFTAKQTLDYAQQLYEKKLLTYPRTDSQYLTEDMGRTAQHLVSDLLGL 328 Query: 343 --FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 F + + H AI P+ + + + KL L+ + + Sbjct: 329 LPFAQGLALTAEVGRVLNSKKVSDHHAIIPTS-EFVKQGFTGLAESECKLMNLVCSKLLC 387 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR-----KGDED----RILP 451 P +Y++ T A+G+ + GW ++ R G+E+ LP Sbjct: 388 AVAAPHEYETVTAVFSCAGNEFAAKGKTVLVPGWKEIDQRFRSTLKTDGEEETETLNTLP 447 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------------------- 486 + +G ++ ++HFT PP ++E +L+ + Sbjct: 448 ELTEGQNFSVT-TDISEHFTSPPKAYTEDTLLSAMERAGAEDMPEDKVNCSAGAREGGLG 506 Query: 487 --EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTA 544 E++G+G P+T A+I+ + G+V+ + ++ K G + L E L + TA Sbjct: 507 QAERKGLGTPATRAAILEKLVQIGFVQRKGKQLVPTKDGINLAVVLPE---SLTSPVLTA 563 Query: 545 QMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGR 604 + EN L ++A A+ + + Q + + + CP C Sbjct: 564 EWENRLTEIAKGNADPDEFMAEIEAQVRQLVKTYSCISADKQNLFQSERVIIGKCPRCSE 623 Query: 605 KMGIRTASTGVFLG 618 + + G Sbjct: 624 NVY--EGKKNFYCG 635 >UniRef50_C5B550 DNA topoisomerase n=1 Tax=Methylobacterium extorquens AM1 RepID=C5B550_METEA Length = 888 Score = 466 bits (1200), Expect = e-129, Method: Composition-based stats. Identities = 175/874 (20%), Positives = 296/874 (33%), Gaps = 125/874 (14%) Query: 1 MGKALVIVESPAKAKTINKYL----------GSDYV------VKSSVGHIRDLPTSGSAA 44 M + L I E PA + I L G ++ V ++GH D G + Sbjct: 1 MPQRLFIAEKPALGRAIATALATLSGARPSAGRGFIEVGGDCVTWTIGHAYDTAEPGDYS 60 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD 104 + V P ++ LK + D Sbjct: 61 S-------------------TWDKWSLDVLPMLPERWKLVPNAEIADQIAVLKDRIRRYD 101 Query: 105 HIYLATDLDREGEAIAWHLREVIGGDD--ARYSRVVFNEITKNAIRQAFNK--PGELNID 160 H D +REG+ I + G D + SRV + + + A P Sbjct: 102 HFVNVGDAEREGQLIVDEILIENGVDPFSPKVSRVWVSSFVEKDVAAAVAGAFPNSQKKS 161 Query: 161 RVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAF 214 A AR+ D ++G +S + + + +S GRVQ+ ++LVV+R+ +I+ F Sbjct: 162 LYEAAVARQRADWLLGMNMSRVFGLMVQQSGARGFRVSVGRVQTPTLKLVVDRDWQIENF 221 Query: 215 VPEEFWEVDASTTTPSGEALALQV----THQNDKPFRPVNKEQTQAAVSLLEKARYSVLE 270 + + + +G A T D R ++K QA V + +V Sbjct: 222 KAVDHFAPSITFVHENGTFKAAWQFPADTKGLDPEGRLLDKAVAQALVQKIAGKTGTVES 281 Query: 271 REDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQ 329 + P ++ P PF STLQ+A S + G ++T+ +AQ LYE ITY R+DS +L Sbjct: 282 YSETPKSTSPPLPFALSTLQKACSQKFGLTAQQTLDVAQELYEKHKAITYPRSDSQHLPN 341 Query: 330 DAV-NMVRGYISDNFGKKYLPESPNQ-------YASKENSQEAHEAIRPSDVNVMAESLK 381 + G + + G + L ++ + A + H I P+ A L Sbjct: 342 SVHTDEADGILRNLAGVRELADAAGRANPKLKSPAFDDKKVTDHHGIIPTS-EASASKLA 400 Query: 382 DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPAL 441 M +K++ LI R FVA +Y S+ TV R KA G + GW V A Sbjct: 401 AMGEIERKVFLLIARTFVAQFHPDFRYVSSAATVLCEGERFKATGTRVVDQGWKTVFGAE 460 Query: 442 RKGDEDR---ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------ 486 +E+ LP++ D + + TKPPA F + +LV+ + Sbjct: 461 EADEEEEAEGTLPSMKMKDPVDAKAGSIDPKRTKPPAHFDDGTLVEAMAKIHLYVQDQEV 520 Query: 487 -----EKRGIGRPSTYASIISTIQDRGYVRV----ENRRFYAEKMGEIVTDRLEENFREL 537 E GIG +T AS+I + Y+ + + + G + D L +L Sbjct: 521 RKRLRENDGIGTEATRASMIEKLIRAKYLERRTKGKRKILVSTDAGRQLVDLLP---SDL 577 Query: 538 MNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK--DPEEGGMRPNQMVLT 595 + D TA E+ L++V E +D +++ A + G + Sbjct: 578 VAPDTTAMWESFLERVKGGEFTLAQFMDRQTQFVRKRVQTAIAAGAIQVKGFSVEPLEGH 637 Query: 596 SIDCPTCGRKMGI-------RTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 +CP C + FL C + + C+ EG Sbjct: 638 GTECPHCRAGHLVTQLWPFDDEYKGRRFLRCDNWVKDRADNCRYKTP----------PEG 687 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 CP CG + + K + C + E+ + Sbjct: 688 YKEREKLEGEGNPCPACGKGVLKGGVVRKEGPNRGRPFLMCSEVDREKPDSCQHFEWKDE 747 Query: 709 VECEKCGSEMHLKM-------GRFGKYMACT-----NEE-CKNTRKILRNGEVAPPKEDP 755 C CG + + + + C+ N + C++ + K Sbjct: 748 TPCPSCGKGVLKRGVVRKEGPNKGRPFAMCSAVDRTNPDGCQHFSWLDEKA----AKGPK 803 Query: 756 VPLPELPCEKSD-AYFVLRDGAA--GVFLAANTF 786 + C + R G FL+ + + Sbjct: 804 IKGEGELCTVCGKGTMMRRTGRTSGKPFLSCSNW 837 >UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 Length = 679 Score = 466 bits (1199), Expect = e-129, Method: Composition-based stats. Identities = 159/698 (22%), Positives = 274/698 (39%), Gaps = 97/698 (13%) Query: 5 LVIVESPAKAKTINKYLG------------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 L + E P++AK I K LG D +V + GHI + ++ AD + Sbjct: 3 LFLCEKPSQAKDIGKVLGVLGGRHDGYFQNGDTIVTWAFGHILTQAAPDAYGEQYADFGN 62 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 ++ + + P W+ +V P K +K L KAD + +ATD Sbjct: 63 ---------------ISALPILPE-VWQM--QVPPKVSKQFKVIKSLLAKADEVVIATDA 104 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRF 170 DREGE IA + + G + SR + + ++++A + PG+ + A AR Sbjct: 105 DREGEVIAREILDYCG-YRKKISRFWTSGLDTQSVKKALSSIMPGKDKENLYQAGLARGR 163 Query: 171 MDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 D +VG +S + G LS GR+Q+ ++LVV+R++EI FVP ++ + Sbjct: 164 ADWLVGMNLSRAYTAAYSAGYGREHILSIGRIQTPTLKLVVQRDKEIDTFVPYNYYTLSV 223 Query: 225 STTTPSGEALALQV---THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 T + + N E +A V LEK+ V+ + ++ P Sbjct: 224 DFETADKSVFTTLWQVPENWRNTDGYCTNLEAVKALVKQLEKSTGKVITSNKERKSTPPP 283 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT-YMRTDSTNLSQDAVNMVRGYIS 340 P+ S LQ+ A +LG K + +AQ LYE IT Y RT L + ++ V+ + Sbjct: 284 LPYSLSALQKEAGKKLGLSASKVLKIAQTLYEKYKITSYPRTPCRYLPKSQMSEVKDVFA 343 Query: 341 --DNFGKKYL--------PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKL 390 K L + + ++ +H AI P+ + L ++ + + Sbjct: 344 AIQTIDKSMLSVIEKADPERQSRVWNDNQVNKHSHHAIIPTKASNF--DLSVLDKNELTV 401 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG----DE 446 Y++I +++A +YDST + V A KA + GW ++ DE Sbjct: 402 YRMIRDRYIAQFYPDFEYDSTVVEVEACSHLFKASSQSPVISGWKVLLGKDVFEGDQIDE 461 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE------------------- 487 LP + D + + P T PP RF+EASL+ E++ Sbjct: 462 GPALPHLKVNDEVDTLSFNPETKKTTPPPRFTEASLLDEMQTLKDFLKNVEDEQIRKILK 521 Query: 488 -KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546 G+G +T A+II + + GY+ + + YA + G + R+ + + TA+ Sbjct: 522 STEGLGTEATRATIIDRLFEMGYMEKKRSKIYATEKGRNLIARIPTM---IADPITTAKW 578 Query: 547 ENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID-------- 598 E +L + + + + T+ + +A+KD P Q Sbjct: 579 ELALAGIEAGKLTLAEFMAYQQKVITELVGQAKKDAVGKARPPKQTDSAGTKKQAVARNE 638 Query: 599 ---CPTCGRKMGIRTA----STGVFLGCSGYALPPKER 629 CPTC + + GCS + Sbjct: 639 DDVCPTCKEGRLRQRGFKENPDKRYWGCSRFPECKHFE 676 >UniRef50_B1ZYV6 DNA topoisomerase n=11 Tax=Bacteria RepID=B1ZYV6_OPITP Length = 939 Score = 464 bits (1195), Expect = e-129, Method: Composition-based stats. Identities = 152/675 (22%), Positives = 264/675 (39%), Gaps = 99/675 (14%) Query: 3 KALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LVI E P+ A + + LG YVV +VGH+ +L Sbjct: 2 KSLVIAEKPSVAADLARALGKIPKQGDHYENDQYVVSYAVGHLVELEMPEDI-------- 53 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIYLA 109 D++ R+ P + + + + + LK+L + + + A Sbjct: 54 ----------DKKKYGFWRLETLPIIPEKFGLKPIEESKDRFNALKKLLARKDIELVINA 103 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNID--RVNAQQA 167 D REGE I +L ++ R +T IR+AF + A + Sbjct: 104 CDAGREGELIFAYLYQLTKC-KLPVKRAWMQTMTAEGIREAFAHLRDGEQMAGLAAAARC 162 Query: 168 RRFMDRVVGYMVSPLLWKKI-----ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 R D ++G + L K++ S GRVQ+ + +V RE EI+ F P +W++ Sbjct: 163 RSESDWLIGINGTRALTKRMFGSRAGNVASVGRVQTPTLAIVYSRELEIRNFKPRAYWQI 222 Query: 223 DASTTTPSGEA--------LALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDK 274 A+ +G ++D+ R + +A V+ + + + E K Sbjct: 223 TATFEVTNGRYEGTYQRPDFKKSDADEHDRVDRIWEQAVAEAIVAACQGQPPAAVREEKK 282 Query: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTNLSQDAVN 333 +T + +TLQ+ A+ R G ++T+ +AQ LYE ITY RTDS L +D + Sbjct: 283 ASTQIAPRLYDLTTLQREANNRFGLSARRTLQIAQALYERHKMITYPRTDSRALPEDYIP 342 Query: 334 MVRGYISDNFG------KKYLPE---SPNQYASKENSQEAHEAIRPSDVNVMAESLKDME 384 VR + + G ++ L + PN+ H AI P+ K ++ Sbjct: 343 TVRETLKNLHGPLAPHAQQVLDQGWVRPNRRIFNNAQISDHFAIIPTAHEA-----KHLD 397 Query: 385 ADAQKLYQLIWRQFVACQMTPAKYDSTT-LTVGAGDFRLKARGRILRFDGWTKVMPALRK 443 K++ +I R+FVA PA++D TT ++ AG K G++L GW V Sbjct: 398 EMEAKVFDMIARRFVAAFFPPAEFDITTRISTVAGRHEFKTEGKVLTVPGWLAVYGRTTV 457 Query: 444 GDE---DRILPAVNKGDALTLV------------ELTPAQHFTKPPARFSEASLVKELE- 487 D+ + LPA++ D T+ + TKPP R++EA+L+ +E Sbjct: 458 EDDAPGSKSLPALSDADRATVARGDDAPAQAKTLDPVLHAETTKPPPRYTEATLLSAMEG 517 Query: 488 ---------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 +RG+G P+T A I + ++ Y+ R E + L Sbjct: 518 AGKLVDDEDLAEAMKERGLGTPATRADTIDGLINQKYMERGQRELIPTAKAEQLLQFLSA 577 Query: 533 NFRE-LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 + L + T + E L Q+ + + + + +D+ + E+ Sbjct: 578 VHTDALTSPAMTGEWEFKLRQIEHGKFSREEFMQEVVEQTKGIVDRVKNFEEDDSA---- 633 Query: 592 MVLTSIDCPTCGRKM 606 T I PT + + Sbjct: 634 ARETDIPSPTDNKPL 648 >UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YF11_METS5 Length = 681 Score = 464 bits (1195), Expect = e-129, Method: Composition-based stats. Identities = 159/699 (22%), Positives = 288/699 (41%), Gaps = 82/699 (11%) Query: 4 ALVIVESPAKAKTINKYLGSD-----------YVVKSSVGHIRDLPTSGSAAKKSADSTS 52 LVI E P+ A I + LG Y+V + GH+ ++ Sbjct: 2 KLVITEKPSVALDIARALGKPTRRQGYLEVGEYLVTWTYGHLLEI--------------- 46 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 E + P + Y+++ GKE +++L E AD + D Sbjct: 47 ---------GEIAPKRWNLKDLPIFPEKFEYDLIKGKESQFKVVRKLLEGADAVINCGDA 97 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNE-ITKNAIRQAFNKPG--ELNIDRVNAQQARR 169 REGE I L E G + R+ +E +T++ + + + + AR+ Sbjct: 98 GREGELIVRELLEFTG-YRGKVLRLWTSEALTRDVVLRELRRLRPSSEFDSLYYSALARQ 156 Query: 170 FMDRVVGYMVSPLLWKKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D +VG ++ L+ K G S GRVQ+ + ++V+R+REI+AF PE ++ V A Sbjct: 157 NGDWIVGINLTRLVTLKAGGGEVWSVGRVQTPTLAMIVKRDREIEAFKPEIYYVVLAGFE 216 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 V +N + R +E Q +L V + + + +P + Sbjct: 217 GEMK-----GVMLRNGEEARLAREEAEQVVNALKSVRSGRVEKVDVERREERPPLLHSLT 271 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 +LQ+ A+T G K+T+ +AQ LYE I+Y RTD+ L + ++V+ + + Sbjct: 272 SLQREANTLYGLSAKRTLDVAQSLYEEWKLISYPRTDARYLGEGNRDLVKDVLRKLGRGE 331 Query: 347 YLP--ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMT 404 +P + + + H AI P D +++ A +K+Y L++R+FV M Sbjct: 332 LVPRVDRVGKRVFDSSKLTDHHAIIPLDRPP-----ENLPAIHRKVYDLVYRKFVGAFMD 386 Query: 405 PAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 464 Y+ + + G+ GW ++ P ED L + G+ + + Sbjct: 387 DYVYELQRVFIRLDGELFLVEGKRNLQLGWMELYPH-----EDNPL-KIPSGE-VRKEWV 439 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 + TKPPARF+EASL++E+E+ G+G P+T A II T+ +RGYV + Y+ G Sbjct: 440 KAEERQTKPPARFTEASLLREMERLGLGTPATRAGIIETLLERGYVERRGKSLYSTDKGR 499 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQV---ANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 + D+L + ++++ D TA+ E L+++ E ++ ++ +++++ K Sbjct: 500 ELVDKLGD--SKVVSPDMTAEWERQLEEIYVKRLGEKGYQEFMEGIRRFTREEVERLMKR 557 Query: 582 PEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENE 641 + R +L R +G++ TG+ + L Sbjct: 558 EFKVERRATPEMLRL--ARAVSRDLGVKLEGTGM--------------EEVKRFLDENLP 601 Query: 642 VLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 + + E +C KCGT + + K Sbjct: 602 KMRITCKCGGEVVGFSRGWKCRKCGTVVWREIAGKKITF 640 >UniRef50_C7J0A2 DNA topoisomerase n=2 Tax=Magnoliophyta RepID=C7J0A2_ORYSJ Length = 928 Score = 464 bits (1195), Expect = e-129, Method: Composition-based stats. Identities = 174/857 (20%), Positives = 290/857 (33%), Gaps = 106/857 (12%) Query: 3 KALVIVESPAKAKTINKYLGSD------YVVKSSVGHIR--DLPTSGSAAKKSADSTSTK 54 + L + E P+ AK++ + L +S + D G A S + Sbjct: 11 RVLNVAEKPSVAKSVAEILSRPSGGMRSREGRSRYNRVFEFDYSIGGRACHMLVTSVTGH 70 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYE--VLPGKEKVVSELKQLAEKADHIYLATDL 112 + D DP + A V K+ + L++ A K + L D Sbjct: 71 LMELEFDD---RFRRWHSCDPADLFHAPVRKSVPQDKQDIKRTLEEEARKCQWLVLWLDC 127 Query: 113 DREGEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRF 170 DREGE IA+ + ++ G ++R R F+ + I +A N +A AR+ Sbjct: 128 DREGENIAYEVIDICAGANSRLNIWRARFSALIDREIHEAVQHLDRPNKLFADAVDARQE 187 Query: 171 MDRVVGYMVSPLLWKKIARG-------------LSAGRVQSVAVRLVVEREREIKAFVPE 217 +D +G + + LS G Q + +VER EI+A PE Sbjct: 188 IDLRIGASFTRFQTMLLKDAFVLDDTGDDRNIILSYGPCQFPTLGFIVERFWEIQAHEPE 247 Query: 218 EFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTT 277 EFW ++ S T+ G F + +E+ +V ++ Sbjct: 248 EFWTINCSHTSDEG---TASFGWIRGHLFDYSSAVVIYEMC--VEEPMATVQNVRNQEKL 302 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD--AVNMV 335 P P T LQ+ AS + TM +A+ LY+AG+I+Y RT++ N S + ++V Sbjct: 303 KYPPYPLSTIELQKRASRYFRMSSEHTMKVAEELYQAGFISYPRTETDNFSPNTDLHSIV 362 Query: 336 RGYISD----NFGKKYLPESPNQYASKEN---SQEAHEAIRPSDVNVMAESLKDMEADAQ 388 ++ + ++ L + + N +AH I P+ + + D + + Sbjct: 363 HEQVAHPNWGTYAQRLLDPEARLWRNPSNGGHDDKAHPPIHPTKFSAGETNWTD---NHK 419 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR 448 KLY+L+ R F+AC PA TT+ + + A GR++ + V G Sbjct: 420 KLYELVVRHFLACCSQPAVGAETTVEIDIAGEQFNASGRVVLAKNYLDVYRFDSWGG--T 477 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508 +LP G LT T+PP +EA L+ ++K GIG +T I + DR Sbjct: 478 LLPTYIIGQQFVPTTLTLDSGMTRPPPLLAEADLLGCMDKAGIGTDATMHDHIKKLLDRC 537 Query: 509 YVRVE-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 Y + N RF +GE + +E EL + ME + V+ VL++ Sbjct: 538 YATKDANTRFSPTNLGEALVMGYDEMGYELWKPYLRSMMEADMKSVSIGTKSKSEVLENC 597 Query: 568 FSDFTQQLDKAEKDPEEGG--------------MRPNQMVLTSIDCPTCGR-KMGIRTAS 612 A + + + T C C +M ++ Sbjct: 598 LQQMKACFLDARANKVKLFDAMGTFFARSSRPVNETQNSIETVRPCAACNESEMFLKQRP 657 Query: 613 TGVF-LGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDS 671 TG F +GC G+ +C+ + L + A + CP C Sbjct: 658 TGEFMVGCRGFP-----QCRNVVWLPRSL------------SGAAVTDQVCPTCAPGPVY 700 Query: 672 YLIDPKRK----------LHVCGNNPTCDGYEIEEGEFRIKG----YDGPIVECEKCGSE 717 + R+ C CD E E G P + S Sbjct: 701 KIQFKFRRRDIPPNFDVDHLGCIG--GCDDILKELMELSRFGSHSQTATPARNQSQTASG 758 Query: 718 MHLKMGR---FGKYMACTNEECKNTRKILRNG-EVAPPKEDPVPLPELPCEKSDAYFVLR 773 + R + T + G + ++ C VLR Sbjct: 759 VRQGSSRQDLHTSFHPAVQFTNGQTPVVNPQGFRSTHTQSSGNASGQVQCTSCREPCVLR 818 Query: 774 DG-----AAGVFLAANT 785 F Sbjct: 819 TANTEANRGRKFYKCQN 835 >UniRef50_UPI00006CC0A9 DNA topoisomerase family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CC0A9 Length = 1049 Score = 464 bits (1194), Expect = e-129, Method: Composition-based stats. Identities = 150/847 (17%), Positives = 288/847 (34%), Gaps = 128/847 (15%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + L + E P+ AK I++ LG+ D + + + + Sbjct: 1 MKQILNVAEKPSVAKEISRVLGNGSQKT------LDSESKYNPVFQFEYKLKQEQVNMLF 54 Query: 61 KDERGALVNRMGVDPWHNWEAHYE-------------VLPGKEKVVSELKQLAEKADHIY 107 G L+++ D + NW++ V K + L + A + D + Sbjct: 55 TSVTGHLISQKFDDKFKNWKSFNPSVLLDQSSEILKFVESDKISIQRNLIKWARQVDTLI 114 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQA 167 L D DREGEAIA+ R F+ + + + A N + + A ++ Sbjct: 115 LWLDCDREGEAIAYE-------------RAWFSSLDRLNVTNAINNLRDPRKELSEAVES 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARG----------LSAGRVQSVAVRLVVEREREIKAFVPE 217 R +D +G + + +S G Q + VV+R +I F E Sbjct: 162 RMEIDLRIGSAFTVFQTLNLKNNFQSLKDKKEVISYGPCQFPTLGFVVDRYNQILKFQDE 221 Query: 218 EFWEVDASTT-TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKA----RYSVLERE 272 +FW + S + + L + + + F + E + V+++ Sbjct: 222 KFWYIQPSYQWKDNNKTLTVDLKWSRGRLFDQAIASVFYLNCTQNEDGEYDPKGIVVKKN 281 Query: 273 DKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV 332 ++ TT P T L + L +K M A++LY++GYI+Y RT++ Sbjct: 282 ERDTTKIRPYPLTTVDLTKQGCRILRMASEKIMHTAEQLYQSGYISYPRTETNKYPDTFQ 341 Query: 333 N-----MVRGYISDN---FGKKYLPESPN--QYASKENSQEAHEAIRPSDVNVMAESLKD 382 N +VR + F L + N + + + +AH I P + + Sbjct: 342 NGQLMDLVRNQKQSDEWGFYSSNLIDQGNFQRPRAGKQDDKAHPPIHPIKL----ANKNQ 397 Query: 383 MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR 442 ++ + K+Y+ I R F+A A T + V D G +++ + ++ + Sbjct: 398 LKPEEWKVYEFITRHFLASCGKDAVGAKTEVEVKFNDESFNIDGLVVKEKNYLEIWTYEK 457 Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 D I+P + G + ++ + T PP +E+ L+ + K GIG +T I Sbjct: 458 WNDS--IVPPLQPGQVIIPQKILLQEGKTTPPKPLTESELIDMMNKNGIGTDATMHDHIL 515 Query: 503 TIQDRGY-VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWK 561 TIQ RGY V+ ++ F +G + ++ L D A+ME + VA + + Sbjct: 516 TIQKRGYAVKNQHLMFTPTPLGLALCHAYDQLGLTLSKPDLRAKMERLMSDVAEGKTTRE 575 Query: 562 AVLDHFFSDFTQQL---------------DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKM 606 A++ + ++ ++ N + +C C + M Sbjct: 576 AIITQIMEEMKSIYKTVEQNKQLFIKSVGEQLKEQENSASTLNNSNIQPGSECGKCQKIM 635 Query: 607 GIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 ++T L C+ C + ++ N RCP C Sbjct: 636 ELQTNDYQRQLVCN--------PCNKSYSIPKNG-------------NLNFRNERCPLCN 674 Query: 667 TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG 726 + D ++C P+C E + + +K Sbjct: 675 FQVLEVTTDKGISYNIC---PSCYNNPPYEQDIENSNANSEDSNFKKTSM---------- 721 Query: 727 KYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGA--AGVFLAAN 784 C N+ C + + + C ++ +R+ F+ Sbjct: 722 PCYKCINKNCSLSGGLKN-------------ISLYNCPCCNSPIQIRETKKDKKQFIGCT 768 Query: 785 TFPKSRE 791 +P Sbjct: 769 KYPDCDW 775 >UniRef50_O28469 DNA topoisomerase 1 n=8 Tax=Euryarchaeota RepID=TOP1_ARCFU Length = 663 Score = 464 bits (1193), Expect = e-129, Method: Composition-based stats. Identities = 177/683 (25%), Positives = 287/683 (42%), Gaps = 55/683 (8%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+I E A+ I L D V G + + + A PK+ Sbjct: 6 LIITEKDNTARRIASILFKD-VKTLKKGRVSYYHSPSNDAYVVGLKGHIVELDFPKE--- 61 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 L N +A + + S LK++A+KAD + +ATD DREGE I Sbjct: 62 --LNNWTKTPLEKLLQAELVKKVKERTISSILKEIAKKADRVTVATDYDREGELIGVEAL 119 Query: 125 EVIGGDDARYS--RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 E++ + RV ++ +T+ IR AF+KP +++ + NA AR+ +D + G ++ L Sbjct: 120 EIVKSVNPTVKVDRVRYSAVTEKEIRSAFSKPVKVDFNLANAALARQKIDLIWGATLTRL 179 Query: 183 LWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 + R LS GRVQ+ +RL+V+RE EI+ F PE+++E+ A Sbjct: 180 ISVHSGRMGKDFLSVGRVQTPTLRLIVDRELEIQNFKPEKYYEIFAEFEG---------- 229 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 P R +KE+ + + + V E + PF T+ + AS Sbjct: 230 -FIAKHPKRYGSKEEAEKLFAKI-GETAKVEEFTRRRMEENRPTPFNTTEFLREASKF-- 285 Query: 299 FGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-VNMVRGYISDNFGKK---YLPESPNQ 354 K M +A+ LY GYI+Y RTD+T + + +S F ++ L + Sbjct: 286 MSPHKAMNIAETLYMNGYISYPRTDNTVYPPTINLIEIVSALSSVFPREAQIVLSQDKIT 345 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLT 414 + + H I P+ V E + D +Y+L+ R+F+A A +D + Sbjct: 346 PSRGRRETKDHPPIYPTGVAKRGE----LSKDEWTIYELVVRRFLATLAPKAVWDVRRVV 401 Query: 415 VGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPP 474 + + + A GR L GW + + E+ LP + KGD L +++ + TKPP Sbjct: 402 LDSNGVKFVANGRQLVEAGWRDIYIYSKA--EETELPLLKKGDVLRILKKRLEEKETKPP 459 Query: 475 ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENF 534 R+S +SL+K +EK +G ST II + R Y+ F + V + L+E Sbjct: 460 GRYSASSLIKMMEKLNLGTKSTRHEIIQKLVSRRYIH--GNPFRPSETAFSVINVLKETA 517 Query: 535 RELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN-QMV 593 + D TA++EN +D +A + V+D Q L + +R + Sbjct: 518 ETITLPDMTAKLENEMDLIAEGKKREPEVVDESREMLLQILRAIDYRKLSKDLREGVKKD 577 Query: 594 LTSIDCPTCGRKMGIRTASTGV-FLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 CP CG ++ +R + G F+GCS Y C T+ L P+N L + + E Sbjct: 578 KIVGKCPECGGELVVRQSKAGKRFIGCSNYP-----DCTFTLPL-PQNGTLYITAKQCKE 631 Query: 653 TNALRAKRR---------CPKCG 666 K R CP C Sbjct: 632 HEIKEVKIRTKKGYWNLGCPYCN 654 Score = 48.5 bits (114), Expect = 0.001, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 16/38 (42%), Gaps = 2/38 (5%) Query: 762 PCEKSDAYFVLRDGAAGV-FLAANTFPKSRETRAPLVE 798 C + V+R AG F+ + +P T PL + Sbjct: 582 KCPECGGELVVRQSKAGKRFIGCSNYPDCTFTL-PLPQ 618 >UniRef50_C6N6E9 DNA topoisomerase n=2 Tax=Legionella drancourtii LLAP12 RepID=C6N6E9_9GAMM Length = 668 Score = 464 bits (1193), Expect = e-129, Method: Composition-based stats. Identities = 149/681 (21%), Positives = 265/681 (38%), Gaps = 86/681 (12%) Query: 5 LVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 L I E P++AK I LG ++ V VGH+ +L Sbjct: 3 LFICEKPSQAKDIATVLGATTRTDACFEGNEIAVTWCVGHLLELAPPDHY---------- 52 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 RM V P + +K ++ + +L ++A + +ATD D Sbjct: 53 ---------CDSIKPWRMEVLPVVPKQWVLMPQEKTKKQLNAIGKLLKQARSVVIATDAD 103 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFM 171 REG+ I + + R+ + + + +I++A + KPG A R+ Sbjct: 104 REGDVIGREVLDYF-NYQGPVERLWLSALDEESIKKALHSIKPGAATECLYQAGLGRQRA 162 Query: 172 DRVVGYMV----SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D ++G + S L LS GRVQ+ ++LVV+R+ I+ F ++++ + A Sbjct: 163 DWLMGMNLTMAVSSLYALPGQGVLSVGRVQTPTLKLVVDRDLGIEQFKAQDYYVLKALCE 222 Query: 228 TPSGEALALQVT---HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPF 284 + E + +D + + K + V ++ P Sbjct: 223 NINQEPFWVTWEIPEELSDDDGKCIQKASIDEVARKINGKAGRVTSFKELDKREAPPLCL 282 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGY--ISD 341 S+LQQ AS++LG K T+ +AQ LYE +Y RTD L Sbjct: 283 SLSSLQQLASSQLGLSAKHTLDIAQALYEQHKATSYPRTDCGYLPDSQFAEAGAVFDALK 342 Query: 342 NFGKKYLP------ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 + LP A + AH I P+ + +LK M + +YQLI Sbjct: 343 QIDPEVLPLIERCSLQLKSKAWNSDKITAHHGIIPTLNPKV--NLKTMTESERNVYQLIR 400 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI------ 449 ++A + ++ +T+ + KA + GW + +R +E+ + Sbjct: 401 AYYLAQFLGEYEFVQRQVTLDIEAYTFKASAHLPGVLGWKSAIKPIRDLEEEELDTDASE 460 Query: 450 -LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGI 491 +P ++ + +++ +L P TKP +RF+E SL+ + E GI Sbjct: 461 SIPKLHDQEPVSIQKLKPDSRKTKPKSRFTEGSLIAAMKSIANYIENPQLKKILKETSGI 520 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G +T A+I+ T+ R Y++ + ++ + G + RL + + N TA E L+ Sbjct: 521 GTEATRANILETLLSRAYLKRQGKQLISTPKGRELIQRLPQ---SITNPATTALWEQMLE 577 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 +A + L+ + L + EK + + ++ CP C + + R Sbjct: 578 DIALGKHALDDFLEEQSDTLSGMLVQLEKQKPASHILGSN---STYSCPDCQKTLMKRQG 634 Query: 612 STGVFLGCSGYALPPKERCKT 632 S G + GCSGY +CKT Sbjct: 635 SKGAWWGCSGYP-----QCKT 650 Score = 48.2 bits (113), Expect = 0.001, Method: Composition-based stats. Identities = 5/32 (15%), Positives = 13/32 (40%) Query: 763 CEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 C + R G+ G + + +P+ + + Sbjct: 622 CPDCQKTLMKRQGSKGAWWGCSGYPQCKTRFS 653 >UniRef50_B7AD12 Putative uncharacterized protein n=4 Tax=Bacteroides RepID=B7AD12_9BACE Length = 729 Score = 463 bits (1192), Expect = e-128, Method: Composition-based stats. Identities = 144/754 (19%), Positives = 257/754 (34%), Gaps = 107/754 (14%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 + I E P+ A+ I LG + Y V + GH+ L + Sbjct: 2 IVCIAEKPSVARDIADVLGARDKRDGYIEGNGYQVTWTFGHLCTLKEPHEYTPNWKSWSL 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 P + + P E+ ++ L + AD I D Sbjct: 62 GSLPMVPPR-----------------FGIKLISNPTYERQFHVIENLMQHADMIINCGDA 104 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 +EGE I + + G R+ + +T+ AIR+ F K + A +R Sbjct: 105 GQEGELIQRWVMQKAGAR-CPVKRLWISSLTEEAIREGFAKLRDASDFQPLYEAGLSRAI 163 Query: 171 MDRVVGYMVSPLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D ++G + L K + LS GRVQ+ + L+V R+ EI+ FVP+++WE+ Sbjct: 164 GDWLLGMNATRLYTMKYGQNRQVLSIGRVQTPTLALIVNRQLEIQNFVPKQYWELKTVYR 223 Query: 228 T---------------------PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY 266 G A +N ++E+ A + + A + Sbjct: 224 DTTFSAILRKSDEELVLEAEKQKEGAAAKAAKPEENRGIEPITDRERGTALLEQIRNAPF 283 Query: 267 SVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTN 326 ++ K P F ++LQ + + F +T+ Q LYE TY R D+T Sbjct: 284 TITNVTRKNGKEAPLRLFDLTSLQVECNKKFAFSADETLKTIQSLYEKKVTTYPRVDTTF 343 Query: 327 LSQDAVNMVRGYISDNFGKKYLPE-------SPNQYASKENSQEAHEAIRPSDVNVMAES 379 LS D G + + L ++ + H AI P+ Sbjct: 344 LSDDIYPKCPGILKGLRDYQALTAPLEGTTLLKSKKVFDNSKVTDHHAIIPTGQPPQ--- 400 Query: 380 LKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP 439 ++ ++++ LI R+F+A + +TT+ K G+ + GW V Sbjct: 401 --NLTDMERRVFDLIARRFIAVFYPDCLFATTTVIGEVEQIEFKVSGKQILEPGWRVVFG 458 Query: 440 ALRKGDE----------DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE-- 487 + + +LPA G++ + + +T+PP ++EA+L++ +E Sbjct: 459 TPSAQSQEEKDEKGGEEENVLPAFVVGESGPHL-PDLYEKWTQPPRPYTEATLLRAMETA 517 Query: 488 --------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEEN 533 + GIGRPST A+II T+ R Y+R E + A G + + E Sbjct: 518 GKLVDNDELRDALKENGIGRPSTRAAIIETLFKRNYIRKEKKNLIATPTGVELIQIIHEE 577 Query: 534 FRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMV 593 L + + T E L ++ L+ ++ + D N+ + Sbjct: 578 L--LKSAELTGIWEKKLREIEKRTYNAGQFLEELKQMVSEIVMSVLSD------NSNRHI 629 Query: 594 LTSIDCPTC-GRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 P G+ +++ P K K T ++ + Sbjct: 630 TIQAPAPEKGGKNSASSASASDKPKKEPKKRAPRKSAAKKTETATTDSLPAAAEQPASVV 689 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNN 686 + CP CG + + C Sbjct: 690 QADELVGQPCPLCGKGTVI----KGKTAYGCSEW 719 >UniRef50_Q9LVP1 DNA topoisomerase n=6 Tax=Embryophyta RepID=Q9LVP1_ARATH Length = 926 Score = 463 bits (1192), Expect = e-128, Method: Composition-based stats. Identities = 166/861 (19%), Positives = 284/861 (32%), Gaps = 119/861 (13%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIR--DLPTSGSAAKKSADSTSTKTA 56 L + E P+ AK++ L +S I D +G + S Sbjct: 10 TVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSVIGHLM 69 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHY--EVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 + D DP ++A V K+ + L++ A K+D + L D DR Sbjct: 70 ELEFADRY---RKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDR 126 Query: 115 EGEAIAWHLREVIG--GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 EGE IA+ + +V + R F+ + I +A + N A AR+ +D Sbjct: 127 EGENIAFEVVDVCRAVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQEID 186 Query: 173 RVVGYMVSPLLWKKI-------------ARGLSAGRVQSVAVRLVVEREREIKAFVPEEF 219 +G + + +R +S G Q + +VER EI+A PEEF Sbjct: 187 LRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPEEF 246 Query: 220 WEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED-KPTTS 278 W ++ S + G T + +E+ +V+ + Sbjct: 247 WTINCSHQSEEG-----LATFNWMRGHLFDYASAVILYEMCVEEPTATVMNVPHPRERFK 301 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD------AV 332 P P T L++ AS + TM +A+ LY+AG+I+Y RT++ + S Sbjct: 302 YPPYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAGFISYPRTETDSFSSRTDLRAMVE 361 Query: 333 NMVRGYISDNFGKKYLPES---PNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQK 389 R ++ ++ L A+ + +AH I P+ + + D Sbjct: 362 EQTRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHPPIHPTKFSSGESNW---SRDHLN 418 Query: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI 449 +Y+L+ R ++AC PA TT+ + R A GR + + +V G + Sbjct: 419 VYELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVYRFESWGGS--V 476 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 +P KG LT T+PP EA L+ ++K GIG +T I + DRGY Sbjct: 477 IPVYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGY 536 Query: 510 VRVE-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 + N RF +GE + ++ EL + A ME+ +++V+ VL+ Sbjct: 537 ATKDANTRFSPTNLGEALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKTKAEVLETCL 596 Query: 569 SDFTQ-QLDKAEKDPE-----------EGGMRPNQMVLTSIDCPTCG----RKMGIRTAS 612 LD K + ++ C M +R Sbjct: 597 QQMKACFLDARVKKSKLLEAMTIFFERSNNTDESESQTAGEVVRRCNLCNESDMALRKNR 656 Query: 613 TGVF-LGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDS 671 G F +GC Y +C+ + L A C CG Sbjct: 657 DGNFMVGCMNYP-----QCRNAVWL------------PGPTLEASVTTNVCQSCGPGPVY 699 Query: 672 YLIDPKRK--------------LHVCGNNPT-----CDGYEIEEGEFRIKGYDGPIVECE 712 ++ R+ + C + C + ++ Sbjct: 700 KILFKFRQIGIPPGFDVNHLGCVGGCDDILKQLIDICGTGSRSQARRTPGTAPSNNIQGS 759 Query: 713 KCGSEMHLKMGRFGKYMAC-----TNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD 767 + + C + C + RN + C Sbjct: 760 N--------TRQSNVCIHCQQRGHASTNCPSRVPASRNSRPTATNPRNDEST-VSCNTCG 810 Query: 768 AYFVLR----DGAAGV-FLAA 783 + VLR + G F + Sbjct: 811 SQCVLRTANTEANRGRQFFSC 831 >UniRef50_C0FN62 DNA topoisomerase n=31 Tax=Bacteria RepID=C0FN62_9FIRM Length = 709 Score = 463 bits (1190), Expect = e-128, Method: Composition-based stats. Identities = 148/674 (21%), Positives = 261/674 (38%), Gaps = 90/674 (13%) Query: 4 ALVIVESPAKAKTINKYLGSD-----------YVVKSSVGHIRDLPTSGSAAKKSADSTS 52 LV+ E P+ A +++K +G+D Y+V VGH+ +L + +K A Sbjct: 19 KLVLAEKPSVAMSLSKVIGADQRGDGYMEGNGYLVSWCVGHLVELSQPEAYDEKYAKW-- 76 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIYLAT 110 + + + P H Y+V +K LK+L + + + AT Sbjct: 77 --------------KYDDLPILPEH---WQYQVSASTKKQFGILKKLMQRKDVESLICAT 119 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQAR 168 D REGE I + G R+ + + +AIR+ F K PG A R Sbjct: 120 DAGREGELIFRLVYHQCGC-KKPVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCR 178 Query: 169 RFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D +VG + L + L+ GRV + + +VV R+ I+AF PE F+ + Sbjct: 179 ERADWIVGINATRLFSCLYGQTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYSAELKFR- 237 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 Q E + + + + E K + KP A F ++ Sbjct: 238 ----------DFQAGGERMKEKAEAEKLVAECCQAGSAIITKVEQKEKSEKPPALFDLTS 287 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY---ISDNFGK 345 LQ+ A+ +LGF ++T+ Q LYE +TY RTDS L+ D +V I +F Sbjct: 288 LQREANRQLGFTAQQTLDYTQALYEKKLVTYPRTDSRYLTDDMAPLVPELVSVIQQSF-- 345 Query: 346 KYLPESPNQYAS----KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 + P++P + H AI P+ + + + Q + ++ + + Sbjct: 346 QIQPDAPAPVNTAQVINTKKVTDHHAIIPTK-TAAGYDISSLPSGEQAILTMLTVRLICA 404 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWT----KVMPALRKGDEDRILPAVNKGD 457 TP +Y T + + + +G+ + GW K + K E LP +++G Sbjct: 405 VGTPCRYAETIVEAECAGQKFRTKGKTVTDMGWRQYAGKAVEDAEKNAEAGELPILSEGM 464 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKEL------------EKRGIGRPSTYASIISTIQ 505 L L + + T PP RF+E L+ + E++GIG P+T A+II + Sbjct: 465 TLELAGVDLKEGKTSPPKRFTEDLLLSAMESASSDEFPAGVERKGIGTPATRAAIIEKLV 524 Query: 506 DRGYVRVEN----RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWK 561 +G++ + + G + + E ++ + TA E L ++ + E + Sbjct: 525 QKGFIERRGDKKTKYLCSTDKGNALVTVVPE---QIQSPSMTADWEEKLLKIEHGEYDSD 581 Query: 562 AVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG 621 A + S + + E + + + CP CG + + G F C Sbjct: 582 AFMGEISSMVSGLVKTYEAVKGADVLMQPECKVIG-SCPACGSDVC--ETAKGWF--C-- 634 Query: 622 YALPPKERCKTTIN 635 + CK + Sbjct: 635 ----RDKSCKFALW 644 >UniRef50_C4V616 DNA topoisomerase n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V616_9FIRM Length = 711 Score = 462 bits (1189), Expect = e-128, Method: Composition-based stats. Identities = 164/695 (23%), Positives = 259/695 (37%), Gaps = 103/695 (14%) Query: 5 LVIVESPAKAKTINKYL------GSDYV------VKSSVGHIRDLPTSGSAAKKSADSTS 52 L I E P+ + + L GS ++ V GH+ + Sbjct: 3 LYIAEKPSVGRALATCLPAPHRKGSGWIETGGGVVTWLFGHVLRQAEPEEYDPALKRWRA 62 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 PK E H V + + +K L +AD I A D Sbjct: 63 EDLPILPK-------------------EWHLVVNESAAQQFAVVKGLIARADEIVHAGDP 103 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 DREG+ + + + +G + R++ N + +I A N + + + AR Sbjct: 104 DREGQLLVDEVLDFLG-NTKPVRRILINALDDKSIHDALNDLRDNGDFLPLKLSALARAR 162 Query: 171 MDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 D ++G +S R L GRV++ + LVV REREI+ F P ++ VDA Sbjct: 163 ADWLIGMNLSRAYTLAARRAGHARLVLPIGRVKTPTLALVVRREREIEHFTPATYYLVDA 222 Query: 225 STTTPSGEALALQVTHQNDK-----PFRPVNKEQTQAAVSLLEKARY--SVLEREDKPTT 277 T +GE + ++ R V++ AA + + V + E K Sbjct: 223 LFRTEAGEPFRARWKPSEERTPLDPEGRLVDRAAADAAAASFGEPPADGVVTKYERKKKE 282 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 P PF S LQ A R G+ ++ + AQ+LYE +Y R+D+ L Sbjct: 283 EPPPLPFSLSALQVLAGKRYGYEPQQVLDTAQKLYEEKLTSYPRSDAEYLPVSQHKDAAK 342 Query: 338 YISDNFGKKYLP---------ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ 388 + + P + A + AH AI P+ V +L + A + Sbjct: 343 ILGNLAALSDTPLAAWAQAADSAKKSRAWNDAKISAHHAIIPTTV---PVNLARLTAVER 399 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM--------PA 440 +Y+LI R ++A YD T V ARGR R GW + A Sbjct: 400 NIYELIARAYIAQFCPNYVYDQTKAEVTHHGETFTARGRTERTAGWRTMYRAGKNESEDA 459 Query: 441 LRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK------------ 488 ++ +E +LP + KGDA V + TKPPARF+ A+L++ +++ Sbjct: 460 EKEDEESTVLPPMKKGDAAAFVSAETKERQTKPPARFTPATLLQGMKEIHKYVKDEAAKK 519 Query: 489 -----RGIGRPSTYASIISTIQDRGYVRVENRR--FYAEKMGEIVTDRLEENFRELMNYD 541 GIG +T ASII + R ++ ++ ++ D L + + D Sbjct: 520 MLRDVSGIGTEATRASIIEDLIRRKFLHAAGKKKVLTPTAEAYLLIDALPDT---MTYPD 576 Query: 542 FTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPT 601 TA E+ L +A+ + L + D A GG I CP Sbjct: 577 ATAIWEDQLHAMADGVGTPEEFLAGQAAFARDLCDAARTAQITGG--------EGIPCPA 628 Query: 602 CGRK-MGIRTASTGVFLGCSGYALPPKERCKTTIN 635 CGR M R G F GCS + +C+ T + Sbjct: 629 CGRGVMLKRKGKHGDFWGCSAFP-----QCRMTAD 658 Score = 52.4 bits (124), Expect = 8e-05, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 14/35 (40%), Gaps = 1/35 (2%) Query: 759 PELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRET 792 +PC + R G G F + FP+ R T Sbjct: 622 EGIPCPACGRGVMLKRKGKHGDFWGCSAFPQCRMT 656 >UniRef50_A6GUS8 DNA topoisomerase n=1 Tax=Limnobacter sp. MED105 RepID=A6GUS8_9BURK Length = 670 Score = 462 bits (1189), Expect = e-128, Method: Composition-based stats. Identities = 149/685 (21%), Positives = 261/685 (38%), Gaps = 90/685 (13%) Query: 5 LVIVESPAKAKTINKYLGSDYV------------------VKSSVGHIRDLPTSGSAAKK 46 L I E P+ K I K LG V V GH+ ++ ++ Sbjct: 3 LFIAEKPSMGKEIAKNLGGKMVNQGPAGKPPTHIEVGGDVVTWGFGHLLEMAPPEHYSEA 62 Query: 47 SADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHI 106 + +PK E N + +S +K L +KA + Sbjct: 63 FKKWSFDTLPIEPKSFELLPKSN-------------------AKAQISTIKALLKKASTV 103 Query: 107 YLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRV---- 162 A D DREG+ + L E G + R++ + + ++++A + Sbjct: 104 VNAGDPDREGQWVVDSLLEHFG-NTKPVQRIILQALDEVSVKKALANLQPNTSPQFIGWK 162 Query: 163 NAQQARRFMDRVVGYMVSP---LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEF 219 N+ R+ D G ++ L+ + +S GRVQ+ + LVV R+ I+ F P++F Sbjct: 163 NSAIGRQRSDWFWGMNLTRAHTLVSNVKGQVVSIGRVQTPTLGLVVARDLAIENFKPKDF 222 Query: 220 WEVDASTTTPSGEALALQVTHQN---DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPT 276 + V A A D+ R ++ Q + ++ SV E Sbjct: 223 YAVSAQIVGAEPVFSAKWKPSDAVPVDESGRVLDANIAQTVCAKIKSQTASVTAFEAVDK 282 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 P+ S+LQ AAS +LG G ++ + +AQ LYE +Y RTD L + Sbjct: 283 KQSAPLPYSLSSLQLAASKKLGLGAQRVLDIAQTLYEQKLTSYPRTDCPYLPESQHASA- 341 Query: 337 GYISDNFGKKY------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKL 390 I+ +KY S A ++ AH I P+ ++ + + Sbjct: 342 ELIAKCLPEKYSELVKGASFSIKSGAWNDSKVTAHHGIIPTGQK------ANLSGELAAV 395 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM--PALRKGDEDR 448 Y +I ++A P Y TT+++ + A G+ GW V +G++ + Sbjct: 396 YDMIVLAYLAQFYPPFVYKQTTISLEVAGEKFTASGKAPISQGWKVVFGSEESEEGEDKQ 455 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGI 491 LP + G +L T PP RF+E +L++ + E GI Sbjct: 456 TLPVLQVGQSLICETAQVDAKKTTPPLRFTEGTLIQAMTNVHQLVDDPEIKKRLKETAGI 515 Query: 492 GRPSTYASIISTIQDRGYVRV-----ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546 G +T A+II T++ R ++ + + + + + G + +L + L + T Sbjct: 516 GTEATRANIIETLKMRKFIEIPDSGKDKGKLVSTQNGRKLIAKLPD---SLKSAGITGLF 572 Query: 547 ENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGR-K 605 E +L+ VA E ++ + + ++ A K+ + V S+ CP C + K Sbjct: 573 EQALESVAKGETSLDVFMEKQTAFVKKYVEMARKEA-PATASASTPVAPSVGCPVCEKGK 631 Query: 606 MGIRTASTGVFLGCSGYALPPKERC 630 + + S G F GCSG+ K C Sbjct: 632 LRLLNGSKGAFWGCSGFRDGCKTTC 656 >UniRef50_A7FCC2 DNA topoisomerase n=1 Tax=Yersinia pseudotuberculosis IP 31758 RepID=A7FCC2_YERP3 Length = 815 Score = 462 bits (1188), Expect = e-128, Method: Composition-based stats. Identities = 182/847 (21%), Positives = 313/847 (36%), Gaps = 123/847 (14%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+L+I E P+ A I K LG ++ + +GH+ ++ ++ A+ + D + Sbjct: 4 KSLIIAEKPSVAFDIAKALGGFQKKDNFFESDRIIISNGIGHLVEVYSTEMDAEGTKDLS 63 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLA 109 + + V P H + P + LK+L + D + A Sbjct: 64 A------------------LPVIPSH---FQVKPKPKTISQFNLLKKLMNRPDVGSVINA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQA 167 D REGE I + E IG R+ +T AIR+A+ G +A + Sbjct: 103 CDAGREGELIFRLIYEAIG-SRKPMKRMWIKSMTPTAIREAYENIKDGRFYDRVDDAARC 161 Query: 168 RRFMDRVVGYMVSPLLW------KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 R D +VG S + ++ + L+AGRVQ+ + ++ +RE EI++FV FWE Sbjct: 162 RTEGDFIVGINASRAITAFKSRQERSFQMLAAGRVQTPVLSMITQREDEIRSFVQRTFWE 221 Query: 222 VDASTTTPSGEALALQV------THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 V A+ T SGE + ++Q R ++ +A + + + K Sbjct: 222 VMATFTLASGEYNGRWIPAKSTNSNQESDGSRFFDQSAAKAILDKCRGVEPTSVTEVSKI 281 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTNLSQDAVNM 334 T S P F + LQ A+ R F KKT+ + Q LYE ++Y RT ST L +D + Sbjct: 282 TKSHPPKLFNQTALQIEANKRYKFSAKKTLDLTQALYEKHKMVSYPRTSSTALPEDYGDT 341 Query: 335 VRGYISDNF-GKKYLP-----------ESPNQYASKENSQEAHEAIRPSDVNVMAESLKD 382 V ++ F G +Y + N+ + H AI P ++ Sbjct: 342 VLSIMTHLFTGSEYEKYAAYVTTHNRIDPSNKTIFDNDEISDHFAIIP--AIGSQCNVAG 399 Query: 383 MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR 442 + D K+Y LI R+F+A A Y +T + K GR+L GW V+ Sbjct: 400 LTPDELKIYDLIVRRFIAAFYPVATYSATERLTIVAEESFKTTGRVLLETGWQAVIKQPT 459 Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLV----------------KEL 486 + L A+ +G+ + T PP+RF+ A+L+ K + Sbjct: 460 DNATNS-LCALKEGETAGNKVMGLKTGNTTPPSRFNVATLLAAMQTAGKLVDDDDLAKAM 518 Query: 487 EKRGIGRPSTYASIISTIQDRG---------YVRVENRR--FYAEKMGEIVTDRL-EENF 534 + G+G +T A II + Y+ +E + F + L + N Sbjct: 519 KGCGLGTDATRAGIIEGLLSNKTAAGNAKEPYIVIEGKEQLFVPTPKAMDLISFLRDNNV 578 Query: 535 RELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVL 594 L N T + E L + + + + + + Q +D + E P++ Sbjct: 579 LMLTNPTMTGEWEQKLSLMEHGKYNRQTFMAEIAENTRQMIDTIKVRASEIPAEPHR-DF 637 Query: 595 TSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETN 654 CP C + ST + CS R + + + + +G+ + Sbjct: 638 AGAKCPKCPSALI----STQRTVTCSAECGFKLRRSQFGRDCTDHELAILINQGKSPFFD 693 Query: 655 ALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC 714 +K + P ++ P ++ + +NPT + + C C Sbjct: 694 DFISKNKKPYS----AQLILQPNYEVTLSFDNPT------------VAKGEALSTACPSC 737 Query: 715 GSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLP-ELPCEKSDAYFVLR 773 E++L MG + Y C +C + G E + KS Sbjct: 738 QGEINLLMGNYPSY-KCG--KCAFKLNKVIAGRALSDDEAISLITHGYLGNKSGY----- 789 Query: 774 DGAAGVF 780 G G F Sbjct: 790 TGKKGKF 796 >UniRef50_C5PM09 Possible DNA topoisomerase n=1 Tax=Sphingobacterium spiritivorum ATCC 33861 RepID=C5PM09_9SPHI Length = 704 Score = 462 bits (1188), Expect = e-128, Method: Composition-based stats. Identities = 151/734 (20%), Positives = 288/734 (39%), Gaps = 87/734 (11%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 +VI E P+ A+ + + +G + Y + GH+ L T + + Sbjct: 2 KVVIAEKPSVARDLARVMGAKEVNDGYISGNGYAFTYAFGHLVQLCTPQAYG--FHTWSV 59 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P + + + + + G K ++ +K L +KA+ + +ATD Sbjct: 60 SNLPIIPAQFKLESKKVKKDGKQMDDG--------GALKQLNTIKGLLDKAEEVIVATDA 111 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 REGE I ++ +G + + R+ + T AI++ F E + ++R Sbjct: 112 GREGELIFRNIYYYLG-ANVPFKRLWISSQTDKAIKEGFANLKEGSEYDSLYMSARSRSE 170 Query: 171 MDRVVGYMVSPLLWKKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D ++G + + LS GRVQ+ + ++ R E K F P F+++ A Sbjct: 171 SDWLIGINATQAITLAAGNRGLLSLGRVQTPTLAMICSRFIENKNFKPTAFYKIQAQFEK 230 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 + ++ +++ + E+T A +++ A V + E K P + + Sbjct: 231 EN-----IKFKATSNRIDQKDLAEETLAKITV--GASAKVTKVEGKEVKEPPPLLYDLTN 283 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD------- 341 LQQ A+ + G+ +T+ +AQ LYE ITY RT S + +D + Sbjct: 284 LQQDANKKYGYSADQTLSIAQTLYEKKVITYPRTGSRYIGEDVFEKIEELFQHLADTAEE 343 Query: 342 ---NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 + + N+ + + H A+ +D E M + +Y +I ++ Sbjct: 344 GIATISRNLIGAKLNKRSVDDKKVTDHHALLVTD-----EKPSAMLKEQSNIYNMIAKRM 398 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD-----------ED 447 V D TT+ + A L A+G +++ GW L + + E+ Sbjct: 399 VESFSDVCLKDITTVIMDAEGVELIAKGTVIKQYGWRLSADQLEQPEDDKKDNDDADTEN 458 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GI 491 LP ++ + L ++ L + FTK +EASL+K +E G+ Sbjct: 459 AQLPKLSAEELLEILALDLMEKFTKAKPVHTEASLLKAMETSGKEIDDDEMRQAMKDCGL 518 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G P+T A+ I T+ R Y+R + ++ G V + +++ R + + T + E L+ Sbjct: 519 GTPATRAATIETLFQRDYIRRDKKKLIPTDKGLAVYNLVKD--RAIAKVELTGKWEQKLE 576 Query: 552 QVANHEAEWKAVLDHFFS---DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGI 608 ++ ++ + + H T++L + + P Q V SI CP C + I Sbjct: 577 EMRANKVSYDVFMKHIKDFTVRITKELLQLRISLTQDVEPPKQTV--SIKCPKCDKGSMI 634 Query: 609 RTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 C YA + T++ V E E +T AL+ + K G Sbjct: 635 LYEKVA---QCDHYARGCDFKIWRTLSGVTLEEKEMKNLLEKGKTGALKNLQ--DKEGKK 689 Query: 669 MDSYLIDPKRKLHV 682 +D L+ K+ + Sbjct: 690 VDGVLVFENLKVSI 703 >UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIV4_FIBSS Length = 843 Score = 461 bits (1187), Expect = e-128, Method: Composition-based stats. Identities = 164/748 (21%), Positives = 293/748 (39%), Gaps = 110/748 (14%) Query: 2 GKALVIVESPAKAKTINKYLGSDY-------------VVKSSVGHIRDLPTSGSAAKKSA 48 GK L+I E P+ A + K LG+ +V ++GH+ + Sbjct: 32 GKTLIIAEKPSVAADLVKVLGAKSFKKETAYYESDTTIVSHAIGHLVGIA---------- 81 Query: 49 DSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HI 106 PK + M P + LP + +S L +L ++ D I Sbjct: 82 ---------DPKDIDERYKAWDMKTLPMLPEKFPLVALPTTKAHLSALGKLIKRKDVTTI 132 Query: 107 YLATDLDREGEAIAWHLREVIGGDD---ARYSRVVFNEITKNAIRQAFNKPG--ELNIDR 161 A D REGE I +++ + I + + R+ +T AI+ AF E ++ Sbjct: 133 INACDAGREGELIFYYIVDYILKGNFKGKTFKRLWMQSMTPAAIKDAFEHLRTEEDMVNL 192 Query: 162 VNAQQARRFMDRVVGYMVSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVP 216 NA R D +VG S L + GRVQ+ + ++V+RE E F+P Sbjct: 193 RNAALCRSEADWLVGMNGSRGLTAYNSSMGGFQITPCGRVQTPTLAIIVKREEERNRFIP 252 Query: 217 EEFWEVDASTTTPS----GEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERE 272 ++FW ++AS G+ + + D+ + ++ + Q ++ + S+ E Sbjct: 253 QKFWTIEASFDNAGAGYQGKWFTVDKENGKDRVKQIFDEARAQEILAKCKGKTGSIEE-T 311 Query: 273 DKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDA 331 P+ K G + +TLQ+ A+ R GF K T+ +AQ LYE TY RTDS L +D Sbjct: 312 TAPSQQKCGQLYDLTTLQREANNRFGFSAKTTLSIAQSLYEHYKATTYPRTDSRCLPEDY 371 Query: 332 VNMVRG-----------YISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESL 380 V V+ + + K Y+ +P + + H AI P+ V Sbjct: 372 VAPVKATLGKIEGPLAKFAQEALDKNYVKRTPKVF--DNSKISDHFAIIPTGVVP----- 424 Query: 381 KDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPA 440 K + +K+Y +I ++F+A PA+Y +TT + G+IL G+ + Sbjct: 425 KGLSEAEEKIYTMICQRFIAVFFPPAQYLNTTRITTVENETFITEGKILVDPGFKAIYG- 483 Query: 441 LRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE------------- 487 ++ DE+ +P +N G+ + + + FTKPPA ++E++L+ +E Sbjct: 484 -KESDEESNIPKLN-GNTAKTLAIESKEDFTKPPAHYTESTLLSMMESAGKLVEDDELRD 541 Query: 488 ---KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE-LMNYDFT 543 +RG+G P+T A+II + YV + + + L E L + + T Sbjct: 542 AMKERGLGTPATRAAIIEKLVSDKYVVRDGKEMIPTAKAFDLIKVLSAMNCEALTSPELT 601 Query: 544 AQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP-------NQMVLTS 596 + E +D ++ + +A ++ + + EE + V + Sbjct: 602 GEWEYKMDLISKGKESREAFMNGIIEMTKTMVKNIKGFKEESTTGEASFSPVNGKKVFET 661 Query: 597 IDCPTCGRKMGIRTASTGVFLGCS---------------GYALPPKERCKTTINLVPENE 641 + T + IR + G L S G+ + + +N+ Sbjct: 662 VSRYTTEDGIVIRKITGGKHLSESEIVELLTKRKIGPLTGFRSKKGAEFSAGLIINDQNK 721 Query: 642 VLNVLEGEDAETNALRAKRRCPKCGTAM 669 V V E + E + P G+ + Sbjct: 722 VEFVFEEKPEEIELGEVIGKSPVDGSDV 749 >UniRef50_C0FPK2 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=C0FPK2_9FIRM Length = 680 Score = 461 bits (1186), Expect = e-128, Method: Composition-based stats. Identities = 140/654 (21%), Positives = 245/654 (37%), Gaps = 78/654 (11%) Query: 5 LVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 LVI E P+ A++I LG+ Y+V GH+ +L + A T Sbjct: 3 LVIAEKPSVAQSIAAVLGAKSRHDGYLEGGGYIVSWCFGHLAELADAAVYNAVDAKWT-- 60 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLATD 111 + P + V K+K L++L + D + A D Sbjct: 61 -----------------LAALPIIPTSFRFIVRSEKQKQFDILRELVRREDVAEVVNACD 103 Query: 112 LDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARR 169 REGE I + + G R+ + + +AIR F + + R Sbjct: 104 AGREGELIFRTVY-CLAGCSKPILRLWISSMEDDAIRSGFQQLRSGRDYDGLHQSALCRA 162 Query: 170 FMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 D +VG + R L+ GRV S + L+V+RE EI AFV E F+ V P Sbjct: 163 KADWLVGINATRYFSLMYGRTLNIGRVMSPTLALLVQREAEISAFVAEPFYTVQLDCGFP 222 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTL 289 + R +++ A + + +V E K + K A + ++L Sbjct: 223 ATTD-------------RMKDRKDADAIANACKGKTVTVKSVERKEKSEKAPALYDLTSL 269 Query: 290 QQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 Q+ A+ LG+ ++T+ Q LYE TY RTDS L+ D V G ++ + Sbjct: 270 QRDANRVLGYTSQQTLDYLQALYEKKLCTYPRTDSHYLTDDMEGSVPGLVAAAAAACGVE 329 Query: 350 ESPNQYAS---KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPA 406 + P A H AI P+ ++ + + +++ +L + + P Sbjct: 330 KPPTICAKQVCSSKKVTDHHAIVPT-ISAEKVDMASLPLGEREVLKLAAKGLLRAVDEPH 388 Query: 407 KYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTP 466 +Y T +TV A+G+ + GW + + + LP + L++ + Sbjct: 389 RYAETVITVDCAGQSFTAKGKTVLAPGWKRY--EQEQTEAVPALPVATENQTLSVSAASV 446 Query: 467 AQHFTKPPARFSEASLVKELEK------------RGIGRPSTYASIISTIQDRGYVRVEN 514 T PP F+E +L+ +E +GIG P+T + II + G+V Sbjct: 447 KTGKTTPPKHFTEDTLLAAMENAGKEDMPDDAERKGIGTPATRSGIIEKLVSSGFVERRK 506 Query: 515 RR----FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 + G + L E +L + TA+ E+ L ++ E + +D + Sbjct: 507 SKKITNLLPTSTGTALITVLPE---QLQSPQLTAEWEHRLKEIERGEIAPDSFMDGIAAM 563 Query: 571 FTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYAL 624 + + + P + P+ + CP CG ++ + G F C + Sbjct: 564 LNELVQTYKPIPGAEVLFPSGREVVG-KCPRCGAEVT--ESQKGFF--CENRSC 612 >UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=C4L3B0_EXISA Length = 708 Score = 460 bits (1184), Expect = e-128, Method: Composition-based stats. Identities = 165/696 (23%), Positives = 285/696 (40%), Gaps = 105/696 (15%) Query: 5 LVIVESPAKAKTINK-----------------YLGSDYVVKSSVGHIRDLPTSGSAAKKS 47 L+I E P++A+ + +V +VGH+ +L + Sbjct: 3 LIIAEKPSQAQKLAAPYPSKKRKEEIEISPCPRFPEGAIVVWAVGHLCELQEPSHYRPEW 62 Query: 48 ADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADH 105 P++ + Y + GK K +K+ Sbjct: 63 KSWKYEALPIVPERFD-------------------YRISKGKSKPFYAIKKWLHDRSITD 103 Query: 106 IYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVN 163 + +A+D +REGEAI + + G+ +R+ + +T+ A+ + F++ PGE I + Sbjct: 104 VIIASDAEREGEAIVRLILR-LAGNKKPLARLWISSLTEQAVDRGFSQLLPGEQTIPYYH 162 Query: 164 AQQARRFMDRVVGYMVSPLLWKKIAR-----GLSAGRVQSVAVRLVVEREREIKAFVPEE 218 +R D +VG S + S GRVQ+ + L+V REREIK FVPE Sbjct: 163 EAMSRACADWLVGMNASRAYTTLLKTIGIEDVFSLGRVQTPTLALIVNREREIKQFVPEP 222 Query: 219 FWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 ++EV+A+ G + + K + +E+ A V V + + Sbjct: 223 YFEVEATLAKGRG---TFKAKYTFGKTTKLKTREEADAVVKR-ASGTAIVKTIDKEEKIE 278 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNM---- 334 +P F S LQ A R GFG KKT+ +AQ+LY G+I+Y RTDS ++ D + Sbjct: 279 QPPFWFSLSGLQAEAGKRFGFGAKKTLDIAQKLYTKGWISYPRTDSGFVTPDEATLFPQT 338 Query: 335 -VRGYISDNFG--KKYLPESP--NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQK 389 R SD + + L E P N+ H AI P++ + + D K Sbjct: 339 KARLLKSDAYAGLRDLLTEDPSKNRRYVNAKKVSDHYAIIPTE---ACGDVTRLGGDEAK 395 Query: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI 449 LY LI R+F+A A + TT+ + G +A+G ++ G+ +V+ K E Sbjct: 396 LYDLINRRFLAAFAPAAMLEKTTVDLIDGGDLYRAKGTVVVSPGYRQVVEMKSKDVE--- 452 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIG 492 LPA+ G+ ++ T+PP R++E +L+ + E G+G Sbjct: 453 LPALTVGEEFKEKKVEVLSKQTEPPKRYTEGALIMAMKVAGKQLDDEELIHIMKEVEGLG 512 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 +T A+II ++ RGYV+++ + G ++ D L ++ L + TA+ E L + Sbjct: 513 TEATRANIIDGLKKRGYVQLQKKELVPTDKGRLLIDVLGDSI--LASPVMTAKWEKRLHE 570 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEKDPE-------------EGGMRPNQMVLTSIDC 599 + A ++ +++A+ E G + + C Sbjct: 571 IGQASASAAEFIEQAKKMSVHLVEEAKSRVEAANPEGYTIEAKRYGKKGTTRPKASFGIC 630 Query: 600 PTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 P CG+ + F+GCSGY +E C+ T++ Sbjct: 631 PNCGKGLV----EHPKFIGCSGY----REGCRFTVS 658 >UniRef50_Q02GM2 DNA topoisomerase n=10 Tax=Pseudomonas RepID=Q02GM2_PSEAB Length = 641 Score = 460 bits (1183), Expect = e-127, Method: Composition-based stats. Identities = 220/673 (32%), Positives = 335/673 (49%), Gaps = 64/673 (9%) Query: 5 LVIVESPAKAKTINKYLGS-----DYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKP 59 +VI+E+P K K + L S + V+++ GHIRDLP G + Sbjct: 3 IVIIEAPGKLKKLRSLLPSIRPDVTWQVEATAGHIRDLPVHGQDPQM------------- 49 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 + V +++ HY++L GKEK V+ LK+L +KA IY+A+D DREGE+I Sbjct: 50 -----------LTVGVGQDFKPHYQILSGKEKTVARLKELRQKAVEIYVASDPDREGESI 98 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ + G + Y RV F EITK+ I + P L++ +V +Q+ RR +DR+VGY+V Sbjct: 99 GWHILQAAGIKN--YKRVAFKEITKSCITAELSSPRRLDLPKVASQECRRVIDRLVGYLV 156 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS-GEALALQV 238 +P L + + R +AGRVQSVAV LVV REREI+AF + + V+ + +PS G + Sbjct: 157 TPELRRVMGRPTTAGRVQSVAVYLVVLREREIRAFTAIKHFGVELTFVSPSDGRTWTAEW 216 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLER-EDKPTTSKPGAPFITSTLQQAASTRL 297 Q + L+ R ++E D T P APFI+S+LQ AA L Sbjct: 217 DPVPVFASEEFPYVQDRQLAELVGAIRNVIVETCIDSEETDAPPAPFISSSLQMAAGNAL 276 Query: 298 GFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYAS 357 + KTM +AQRLYE G ITY RTD+ N+S+D++ +R ++ G K + E + + Sbjct: 277 KWSPDKTMKVAQRLYEQGLITYHRTDNPNISKDSMPDIRA-VAKALGLKCV-EQQRMFKA 334 Query: 358 KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV-- 415 +++QE H AI P+D + AD Q LYQLI + +A Q+ A Y T+T+ Sbjct: 335 DQDAQEGHPAITPTD---WMAAAAGETADEQALYQLIRVRALASQIEAAVYAVRTITLLG 391 Query: 416 ---GAGDFRLKARGRILRFDGWTKVMPALRKGDEDR-------ILPAVNKGDALTLVELT 465 R A+G++L GW K++ ++ +PA+ L + Sbjct: 392 VGPDKKPLRFGAKGKLLNVPGWRKLLQGDDAEEQKNETPSNPIPIPALEPRQILKVYSGE 451 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 + T PP RF++ASLV E+++RGIGRPS+YASI+ I D+G V+++ R ++GE Sbjct: 452 VLEKKTTPPKRFTDASLVGEMKRRGIGRPSSYASIVKNIIDKGQVQMKGRSLIPGELGEA 511 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA------- 578 LE NF ++ DFT +E +LD++AN E + V+ F+ +L Sbjct: 512 TIALLEHNF-SFLSLDFTRNLEVALDRIANSEDTYMNVVQQFYQLLQTELQTLRALPSAQ 570 Query: 579 EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRT--ASTGV-FLGCSGYALPPKERCKTTIN 635 ++ + + C CG + R G F GCSGY CK + Sbjct: 571 DEPRASSTASISSAPTSDFLCGKCGLPLVHRKKAGKGGFDFWGCSGYRTT---GCKVSYP 627 Query: 636 LVPENEVLNVLEG 648 + G Sbjct: 628 TKSGRPDFDNPRG 640 >UniRef50_B7GCB2 DNA topoisomerase (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7GCB2_PHATR Length = 520 Score = 460 bits (1183), Expect = e-127, Method: Composition-based stats. Identities = 205/534 (38%), Positives = 301/534 (56%), Gaps = 42/534 (7%) Query: 5 LVIVESPAKAKTINKYLGS---------DYVVKSSVGHIRDLPTSGSAAKKSADSTSTKT 55 LVIVESP+K +TI K L + D+ V SS+GHIR+LP S ++ KK + Sbjct: 1 LVIVESPSKCQTIAKILATYVKDNSLAYDFQVSSSMGHIRNLPKSDTSKKKKENQ----- 55 Query: 56 AKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDRE 115 K G+D + ++ Y +LPGK +V EL+ LA A+ + LATD DRE Sbjct: 56 ----IKPNGKFPYTIAGIDLENGYQPEYVLLPGKGPLVKELQHLAANAELVLLATDPDRE 111 Query: 116 GEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 GEAIAWHL +V+ +RY RV F EIT + I +A P ELN + V+AQ+ RR +DR+ Sbjct: 112 GEAIAWHLTQVLDLAPSRYQRVTFTEITPSRILEAVKSPVELNTNLVHAQETRRVLDRLA 171 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST---TTPSGE 232 GY VSP+LWKKIA GLSAGRVQSV + +VV+RERE F +W + A +P G+ Sbjct: 172 GYTVSPVLWKKIAPGLSAGRVQSVGMAMVVQRERERLCFETTPYWNIKAVLGKDFSPQGQ 231 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 L +H+ R + + V +L A ++V++ + +P PF TSTLQQ Sbjct: 232 ILRPGSSHK-----RHLLEGDANELVKVLSDAEFTVIQVKSTTRKQQPPQPFKTSTLQQE 286 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL---- 348 A+ RLG V++TM +AQ+LYE G I+YMRTDST+LS DA + + FG L Sbjct: 287 ANRRLGMAVQQTMRVAQQLYEEGLISYMRTDSTHLSDDAECAIGVSVRGQFGPDRLWVGS 346 Query: 349 PESPNQYASKENSQEAHEAIRPS----DVNVMAESLKD---MEADAQKLYQLIWRQFVAC 401 ++ + + +QEAHEAIRP+ + + L + A++LY +I+++ +AC Sbjct: 347 SKTKRKPKDSKFAQEAHEAIRPALQPDGIFLEPRYLLQKVALSDQAERLYTMIYQRTLAC 406 Query: 402 QMTPAKYDSTTLTVGAGDF----RLKARGRILRFDGWTKVM-PALRKGDEDRILPAVNKG 456 +M P + T++ + + G ++ G+T + +++ LPA+ +G Sbjct: 407 RMPPIATNQTSVLIAGVQEGTTAHFRVSGSVVIDPGYTLAYCRDAEEENDEAYLPALREG 466 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 L E+ H T+PP R++EAS VKELE G+GRPSTY+ I+ ++DR YV Sbjct: 467 QILNAGEILAVAHETQPPPRYNEASFVKELESLGVGRPSTYSGIVQILRDRAYV 520 >UniRef50_A9V3W6 DNA topoisomerase n=1 Tax=Monosiga brevicollis RepID=A9V3W6_MONBE Length = 803 Score = 459 bits (1182), Expect = e-127, Method: Composition-based stats. Identities = 178/846 (21%), Positives = 301/846 (35%), Gaps = 118/846 (13%) Query: 2 GKALVIVESPAKAKTINKYLGS------DYVVKSSVGHIRDLPTSGSAAKKSADSTSTKT 55 L++ E P+ AK++ L + KS H + +++ ++ Sbjct: 4 PTVLMVAEKPSLAKSLAWILSNHSATSRPSRSKSCTVHEY---SGDFMGQQAQFKFTSVM 60 Query: 56 AKKPKKDERGALVNRMGVDPWHNWEAHYEVLPG--KEKVVSELKQLAEKADHIYLATDLD 113 D N P ++A E K V L+ + D++ L D D Sbjct: 61 GHVMSLDFLPQYNNWERTPPRELFDAETEKKDANPKAHVREALRSEGKGVDYLVLWLDCD 120 Query: 114 REGEAIAWHLREVI------GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQA 167 REGE I + + +++ R F+ IT+ I+ A N + A A Sbjct: 121 REGENICFEVMDIVLPVMNRSVRGQTVFRAKFSAITEKDIKAAMRTLVAPNENESLAVDA 180 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R+ +D +G + + + F PE +W +D Sbjct: 181 RQELDLRMGCAFTRFQTRFF------------------------QTFTPERYWTIDLQLE 216 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFIT 286 SG A + R ++E + + +++A V+ +K T Sbjct: 217 HDSGFLRAQW------ERVRVFDQELGRVFTNRVQEASSARVVSVSEKEKKKPRPNALNT 270 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGYI-SDNF 343 L + S LG G + M +A+RLY GYI+Y RT++T ++ V++++ S N+ Sbjct: 271 VELMRVCSAGLGMGPQYAMAIAERLYMQGYISYPRTETTAYPENFDLVSVLKEQQNSPNW 330 Query: 344 GKKY--LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 GK+ L H I P V D+ D ++Y L+ R F+A Sbjct: 331 GKEVKELLAGAMVQPKGGKDVGDHPPITPMRV----AQESDLGGDDWRVYDLVTRHFIAT 386 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTL 461 KY +TT+ + AG +G G+T VM + E + +P++ +G L + Sbjct: 387 LSPDCKYLTTTIVLDAGGEVFTIQGSRTLSPGFTAVMHWVGSA-EQQTVPSLPEGATLRI 445 Query: 462 VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-NRRFYAE 520 + + L+ +EK GIG ++ I+ I +R YV+++ R Sbjct: 446 KSA-------------TLSDLISLMEKHGIGTDASIPVHINNICERNYVQIQAGRTLVPT 492 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF-------FSDFTQ 573 +G ++ + +L A +E LD +A +A + VL HF F F Sbjct: 493 NLGIVMIHGYKTIDPDLCLPTMRAAVEKQLDLIAKGQAPFDDVLAHFKLLFQRKFEFFEA 552 Query: 574 QLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG--CSG-YALPPKERC 630 + ++ E C C R M +A C +ALP + Sbjct: 553 FISNMDQLFEVTFTPLKSTGKQLSRCGKCNRYMKYVSAKPQRLYCPTCDETFALPQGGKI 612 Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCD 690 L + +L T RA CP C +D + C +PTC+ Sbjct: 613 VLYKELRCPLDKFELLMFTTGTTG--RAYPLCPYCYNNPPFEDMDKASGCNDCT-HPTCE 669 Query: 691 GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAP 750 I+ G + +C +CG ++ L K+ C N C ++ N Sbjct: 670 HSLIQLG----------VTQC-ECGGQLVLDASSKPKWRLCCN-RCNIVIRLFENAH--- 714 Query: 751 PKEDPVPLPELPCEKSDAYFV----------LRDGAAGVFLAANTFPKSRETRAPLVEEL 800 + + + PCE A V L+DG L E APLVE Sbjct: 715 ----SIKITKTPCEACGAMEVDVEFNKTKNPLKDGT----LTRQGCIFCHEDLAPLVELA 766 Query: 801 YRFRDR 806 + R R Sbjct: 767 HAQRMR 772 >UniRef50_P14294 DNA topoisomerase 3 n=211 Tax=Gammaproteobacteria RepID=TOP3_ECOLI Length = 653 Score = 459 bits (1181), Expect = e-127, Method: Composition-based stats. Identities = 133/634 (20%), Positives = 246/634 (38%), Gaps = 82/634 (12%) Query: 5 LVIVESPAKAKTINKYL-------------GSDYVVKSSVGHIRDLPTSGSAAKKSADST 51 L I E P+ A+ I L G+ VV +GH+ + + + A Sbjct: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATD 111 P+ + + P K ++ +K+ +A I A D Sbjct: 63 LADLPIVPE-------------------KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGD 103 Query: 112 LDREGEAIAWHLREVIGG---DDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQ 166 DREG+ + + + + + R + N++ A+ +A ++ + + Sbjct: 104 PDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSAL 163 Query: 167 ARRFMDRVVGYMVSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 AR D + G ++ LS GRVQ+ + LVV R+ EI+ FV ++F+E Sbjct: 164 ARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFE 223 Query: 222 VDASTTTPSGEALALQVTHQN------DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 V A TP+ E D+ R +++ + V+ + V DK Sbjct: 224 VKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKR 283 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQD---- 330 + PF S LQ A+ R G + + + Q+LYE ITY R+D L ++ Sbjct: 284 ESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG 343 Query: 331 ---AVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADA 387 +N + + D + + + +AH AI P+ + ++ + Sbjct: 344 RHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI----NLTENE 399 Query: 388 QKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED 447 K+Y LI RQ++ A + + + + A+ R L GW ++ + + +E+ Sbjct: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN 459 Query: 448 --RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EK 488 LP V KGD L + + T+PP F++A+L+ + Sbjct: 460 DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 Query: 489 RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN 548 G+G +T A II + RG++ + R ++ G+ + L E D TA E+ Sbjct: 520 DGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWES 576 Query: 549 SLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDP 582 L Q++ + ++ + Q +D+A++ P Sbjct: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTP 610 >UniRef50_B1L3G6 DNA topoisomerase I n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3G6_KORCO Length = 710 Score = 459 bits (1180), Expect = e-127, Method: Composition-based stats. Identities = 179/764 (23%), Positives = 312/764 (40%), Gaps = 90/764 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 L++ E P AK I L K G + + + + Sbjct: 2 TTLILTEKPNVAKRIASILSEGAKAKRE-GKVYYYEFDTGGERYYVAPAAGHLLELDYPP 60 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + + + + + + GK + + L++L + ++ I +ATDLD EG +IA Sbjct: 61 GKWEYPSIVPPE-----RLVLKEIKGKREYLKILEKLGKLSNRIIVATDLDSEGSSIALE 115 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 + + + + R+ F+ +TK IR +F + R A RR +D G VS Sbjct: 116 IIKALNWEGKEILRMEFSSLTKEEIRSSFRDLKPFDYPRAYAGWVRRVIDLEWGANVSRG 175 Query: 183 LW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 L K R LS+GRVQ + ++V+REREI+ FVP++++ V + +L+ Sbjct: 176 LTLSTRRKGWVRVLSSGRVQGPTLSMIVKREREIREFVPKKYYTVIVKVD----KGFSLE 231 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + R +++ + A ++ + + P PF ++LQ S Sbjct: 232 LAPPKGEE-RIWDQDYARRAAESVKD--TLIARVKSDERKLSPPPPFDGTSLQVEVSAIT 288 Query: 298 GFGV----KKTMMMAQRLYEAGYITYMRTDSTNLS-----QDAVNMVRGYIS----DNFG 344 G +T +AQ+LYEAG I+Y+ T+S +D V+MV+ S Sbjct: 289 GLTPRQIADRTSGIAQKLYEAGLISYIGTESQKYPKSWKKKDFVDMVKLIASYSPLKEEA 348 Query: 345 KKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMT 404 + L + + AH I V + +E +++Y++I R+ +A Sbjct: 349 EFVLGDMREAAVEGKKDDPAHPTIHVVGVPE-----ERLEGKYREVYEIIARRNLATLAQ 403 Query: 405 PAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 464 A + F +A G + +GW +V P R + P V + L +VE+ Sbjct: 404 DALIKRIRVESNVDGFIFRASGLSVLREGWLRVYPYARMEE----FPEVEDSEELRVVEV 459 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 + T+PP R+S SL+KE+E+ G+G +T II ++ RGY +E F ++GE Sbjct: 460 KIEEKETQPPKRYSHISLIKEMERLGLGTKNTRVQIIDILKSRGY--LEEGSFKPTRLGE 517 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 + + LE L N + TA++E ++++ + + L + + +D+ +++ + Sbjct: 518 AIVEVLESFVPALTNPELTAKLERGMNEIELGKLDPSNFLKESLDELSAIMDEFKRNELK 577 Query: 585 GGMRPNQMV-----LTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPE 639 R + + + CP CG + +R +S G F+ CS Y E+C NL Sbjct: 578 ISERLYEGLREYRSGSLGKCPECGGDLNMRKSSYGYFIVCSNYP----EKCDVKFNLFKN 633 Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLID----PKRKLHVCGNNPTCDGYEIE 695 + C +CG + S I R C N CD + Sbjct: 634 ERF---------------EGKFC-ECGLPLVSGRIKTKSNRGRGYTRCIAN--CDRTPL- 674 Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNT 739 C KCG M K G+FG Y+ C N C +T Sbjct: 675 --------------RCAKCGGPMVAKQGKFGVYLKCEN--CGST 702 Score = 62.4 bits (150), Expect = 8e-08, Method: Composition-based stats. Identities = 18/106 (16%), Positives = 35/106 (33%), Gaps = 27/106 (25%) Query: 708 IVECEKCGSEMHLKMGRFGKYMACTN--EECKNTRKILRN-------------------- 745 + +C +CG +++++ +G ++ C+N E+C + +N Sbjct: 594 LGKCPECGGDLNMRKSSYGYFIVCSNYPEKCDVKFNLFKNERFEGKFCECGLPLVSGRIK 653 Query: 746 -----GEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTF 786 G L C K V + G GV+L Sbjct: 654 TKSNRGRGYTRCIANCDRTPLRCAKCGGPMVAKQGKFGVYLKCENC 699 Score = 43.5 bits (101), Expect = 0.039, Method: Composition-based stats. Identities = 5/27 (18%), Positives = 12/27 (44%) Query: 762 PCEKSDAYFVLRDGAAGVFLAANTFPK 788 C + +R + G F+ + +P+ Sbjct: 596 KCPECGGDLNMRKSSYGYFIVCSNYPE 622 >UniRef50_A8U7S1 DNA topoisomerase n=2 Tax=Lactobacillales RepID=A8U7S1_9LACT Length = 701 Score = 459 bits (1180), Expect = e-127, Method: Composition-based stats. Identities = 161/736 (21%), Positives = 283/736 (38%), Gaps = 99/736 (13%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K L+I E P+ K I + LG D +V ++GH+ L Sbjct: 12 KTLIIAEKPSVGKEIARVLGATQKSKTHIEGKDVIVTWALGHLLGL-------------- 57 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLA 109 K P++ ++ + P + L + +KQLA++ D +A Sbjct: 58 -----KMPEEYKKEWATWDLNTLPLIPEKMLTTPLKNTRSQLKAIKQLADRKDIGSAVIA 112 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQA 167 TD REGE +A + E + + R+ + T AI++ FN+ P + ++ A Sbjct: 113 TDAGREGELVARWILEYVHF-NKPIKRLWISSQTDKAIKEGFNQLQPSKKYDTLYDSAVA 171 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D ++G V+ L K LSAGRVQ+ + +V ++E +I++FVPE F+ V Sbjct: 172 RSEADWLIGLNVTRALTVKYQDSLSAGRVQTPTLAMVRKQEAKIQSFVPETFYTVQLVID 231 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + T Q+ + +++ + V+ L+ V E ++K + + P+ + Sbjct: 232 GK-------KATIQDSALRKFSERQKAEDLVASLKNKSVIVKEIKEKQSIQQAPLPYDLT 284 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYIS--DNFG 344 LQ+ A+ R F KKT+ + Q LYE + +Y RTDS L+QD + ++ ++ NF Sbjct: 285 ELQREANLRYQFSAKKTLSLMQTLYERHKVLSYPRTDSKYLTQDMIGTMKERVAAIQNFA 344 Query: 345 KKYLPESPNQYAS-------KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 + + A H I P++ E MEAD K+Y+++ + Sbjct: 345 PDEVKGILKRGAQVTQKGVFNTAKVTDHHGIIPTEERPRPE---KMEADELKIYRMVVER 401 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 F+ + TT+ A + + GW K + + + Sbjct: 402 FIGLFLPAYNVSKTTIVFSAATTLFSLQQEEVIEKGWKKEVQKQSEKG-------YQLNE 454 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 LT T T+ PAR SE +L++ +EK G+G P+T A II + + + Sbjct: 455 QLTQPTYTIQMQLTEAPARLSEGTLLQNMEKNGLGTPATRAEIIEKLIKSDLMERNQNKL 514 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 G+ + + L+ + T + E +L+++A + + L ++ + + + Sbjct: 515 STTPKGQQLLTLVN---PALVTPELTRKWEEALEEIAKGTLKKEVFLKQIKNETARLVTE 571 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV 637 + E LT+ CP CG + R+ G L CS K R Sbjct: 572 IKNSTETYKDHA----LTTKICPDCGELLKERSGRDGKMLICSSTTCSYKRR-------- 619 Query: 638 PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEG 697 + + RC +C M+ + GN C I E Sbjct: 620 ---------------KDPKVSNHRCAQCHRKMEIHEGKN-------GNYFKCKYCNITEK 657 Query: 698 EFRIKGYDGPIVECEK 713 E K Sbjct: 658 IEGKSSKKPSKHETSK 673 Score = 49.7 bits (117), Expect = 5e-04, Method: Composition-based stats. Identities = 18/124 (14%), Positives = 40/124 (32%), Gaps = 17/124 (13%) Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPP 751 EI+ K + C CG + + GR GK + C++ C R+ Sbjct: 570 TEIKNSTETYKDHALTTKICPDCGELLKERSGRDGKMLICSSTTCSYKRR---------- 619 Query: 752 KEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTF-----PKSRETRAPLVEELYRFRDR 806 + C + + +G G + + + ++ P E + + Sbjct: 620 --KDPKVSNHRCAQCHRKMEIHEGKNGNYFKCKYCNITEKIEGKSSKKPSKHETSKLMKK 677 Query: 807 LPEK 810 + ++ Sbjct: 678 INKQ 681 >UniRef50_C7DGI7 DNA topoisomerase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DGI7_9EURY Length = 727 Score = 458 bits (1178), Expect = e-127, Method: Composition-based stats. Identities = 167/708 (23%), Positives = 279/708 (39%), Gaps = 60/708 (8%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTS-GSAAKKSADSTSTKTAKKPKK 61 K L+I E P+ A I LG+ G I G A + + K Sbjct: 2 KTLIIAEKPSVALRIAIALGNGQHKSVRNGRITYYTMPHGDGEIYVAAAVGHLFTIRQKG 61 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ER + + P + E ++ + LK+LA++ A D D EG I Sbjct: 62 KERAYPITEIEWAPSYLTNKRSEYT---KEYLFTLKKLAQECSTFINACDYDIEGTVIGT 118 Query: 122 HLREVIGGDDARY-----SRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 ++ + + G A R+ F+ T + +F +I+ A +AR +D + G Sbjct: 119 NIIKELSGLQAEAIGSVSKRMKFSTTTPKDLLDSFGSLLPPDINNFYAGEARHMLDWLWG 178 Query: 177 YMVSPLLWKKIA-----RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 S L ++ + LS GRVQ A+ L+ +RE+EI +F PE +W V A + Sbjct: 179 INFSRALTSALSSSGQYKQLSIGRVQGPALGLLAKREKEIASFKPEPYWNVLAYSG---- 234 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + + F E +A + V E +P PF ++LQ Sbjct: 235 ---EFEFINSRGNIFAKQEAESAFSAANSGRD-NAVVSEATSAEQLRRPYPPFDLTSLQL 290 Query: 292 AASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD------AVNMVRGYISDNFGK 345 AS GF T+ MAQ LYE +I+Y RT S L + ++ + Sbjct: 291 EASRVFGFDPSATLAMAQSLYERSFISYPRTSSQKLPRTLGLPRIIADLGKNPAYSTIAA 350 Query: 346 KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTP 405 + + A EAH AI P+ V K + +KLY LI R+F++C Sbjct: 351 EIASKGRFTPAEGPKEDEAHPAIFPTGVTP-----KGITGSEEKLYDLIARRFLSCFGEY 405 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELT 465 AK ++ +L + G + +G + + GW + + D LP + KG + + ++ Sbjct: 406 AKVNNFSLEISIGGETFEGKGSKVTYPGWLDYYKYAKIKERD--LPNLEKGQRVEITDIK 463 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 + T PP RF++A L+ ELEK +G +T A+II T+ R Y+ E + G Sbjct: 464 MPELQTAPPKRFTKAGLISELEKHNLGTKATRAAIIDTLFKRNYI--EGSSIRVTEFGMT 521 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 V D LE+N +++ D T +E +D ++ + VL ++ + E+ Sbjct: 522 VYDALEKNCSMIVDEDTTITLEKDMDLISKGKMPESEVLKKGKEVLLTAIETFNSNKEKI 581 Query: 586 GMRPNQMVLTS---IDCPTCGRKMGIRTASTGV-FLGCSGYALPPKERCKTTINLVPENE 641 + ++ CP G + I+ + G F+ CS Y +C T L + Sbjct: 582 SEEMKESFKSANVLGKCPKDGGDLVIKRSFRGKQFVACSNYP-----KCTNTYPLPQNAK 636 Query: 642 VLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 ++ C C T + + K + +P C Sbjct: 637 IVP-------------TGNACEFCHTPIVKIIRRGKPPFEI-DLDPNC 670 Score = 47.8 bits (112), Expect = 0.002, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 14/32 (43%), Gaps = 1/32 (3%) Query: 762 PCEKSDAYFVLRDGAAGV-FLAANTFPKSRET 792 C K V++ G F+A + +PK T Sbjct: 597 KCPKDGGDLVIKRSFRGKQFVACSNYPKCTNT 628 >UniRef50_Q5HLZ4 DNA topoisomerase 3 n=9 Tax=Staphylococcus RepID=TOP3_STAEQ Length = 711 Score = 458 bits (1177), Expect = e-127, Method: Composition-based stats. Identities = 162/743 (21%), Positives = 272/743 (36%), Gaps = 117/743 (15%) Query: 3 KALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+L++ E P+ + I L G Y+V ++GH+ T + Sbjct: 2 KSLILAEKPSVGRDIANALNLQQKSNGYIEGKQYIVTWALGHLVTNATPEQYNPSYKEWN 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIYLA 109 PK + V+ + +K L + I +A Sbjct: 62 LEDLPIIPK-------------------KMKTVVISKTNRQFKIVKSLILDKNVKEIIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQQA 167 TD REGE +A + + +G + R+ + +TK AI++ F + G + A A Sbjct: 103 TDAGREGELVARLILDKVG-NKKPIKRLWISSVTKKAIQEGFKQLKNGNAYQNLYEAALA 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D +VG + L K LS GRVQ+ +++V R+ EI F PE+++ + + Sbjct: 162 RSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQIVKSRQDEINYFKPEKYYTLSINVD 221 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + R +K++ + ++ +LE + K S F + Sbjct: 222 GYDLNLKQQK---------RYKDKKELELIEHKIKHQEGKILEVKGKNKKSYAQPLFNLT 272 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 LQQ A G K+T+ Q LYE +TY RTDS L+ D V+ ++ + Sbjct: 273 DLQQEAYKHYKMGPKETLNTLQHLYERHKLVTYPRTDSNYLTDDMVDTIQERLRAILATD 332 Query: 347 YLPE---------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 Y S + H AI P++V S++ + K+Y LI + Sbjct: 333 YKSHVRDLISESFSSKMHIFNNQKVSDHHAIIPTEVR---PSIEQLSQREFKIYMLIAER 389 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILP-AVNKG 456 F+ M P Y+ T+ D+ + I + G AL+ L + +G Sbjct: 390 FLENLMNPYLYEVLTIHAQLKDYNFVLKEIIPKQLG----YKALKDQTSSHTLTHSFKEG 445 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEK-------------------RGIGRPSTY 497 + + +H TK P F+E SL+K +E GIG +T Sbjct: 446 QLFKVHRIEIHEHETKAPEYFNEGSLLKAMENPQNHIDLNDKKYAKTLKHSGGIGTVATR 505 Query: 498 ASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHE 557 A II + + + + + G+ + LE + EL + TAQ E L + + Sbjct: 506 ADIIEKLFNMNALESRDGKIKVTSKGKQI---LELSPSELTSPILTAQWEEKLMLIEKGK 562 Query: 558 AEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL 617 + + +FT ++ K E+ N LT+ +CPTCG+ M G L Sbjct: 563 YNSQKFIQE-MKNFTFKVVNKIKSSEQKYKHDN---LTTTECPTCGKFMIKVKTKNGQML 618 Query: 618 GCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK 677 C +CKT N+ + RCP C M + K Sbjct: 619 VC------QDPKCKTKKNIQRKTNA------------------RCPYCKKKM-TLFGKGK 653 Query: 678 RKLHVCGNNPTCDGYEIEEGEFR 700 ++ C C E + + Sbjct: 654 EAVYRC----VCGHTETQSQMDK 672 Score = 47.0 bits (110), Expect = 0.003, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 26/80 (32%), Gaps = 13/80 (16%) Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 +I+ E + K + EC CG M + G+ + C + +CK + I R Sbjct: 582 KIKSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPKCKTKKNIQRK------- 634 Query: 753 EDPVPLPELPCEKSDAYFVL 772 C L Sbjct: 635 ------TNARCPYCKKKMTL 648 >UniRef50_Q5ZHE3 DNA topoisimerase n=9 Tax=root RepID=Q5ZHE3_9BACT Length = 737 Score = 457 bits (1176), Expect = e-127, Method: Composition-based stats. Identities = 155/757 (20%), Positives = 254/757 (33%), Gaps = 108/757 (14%) Query: 5 LVIVESPAKAKTINKYLGSDYV-----------VKSSVGHIRDLPTSGSAAKKSADSTST 53 LVI E P AK I + LG V GH+ L ++ A+ Sbjct: 6 LVIAEKPELAKAIVEGLGGGSRKDGYYECGSDRVTWCYGHMLALLDPEDYDERYANWNMA 65 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 W G + + L ++A + A D D Sbjct: 66 DLPI-----------------VHIPWRKKPSGDAGAKAQFKTILSLLKQAKSVVHAGDPD 108 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQ--AFNKPGELNIDRVNAQQARRFM 171 EG+ + + E R++ N+ +R+ A + A +AR Sbjct: 109 DEGQLLVDEILEYANCR-LPVQRLLINDNNVKIVRRQLAAMRDNREFAGLSAAAEARSVG 167 Query: 172 DRVVGYMVSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D++ G+ ++ L K LS GRVQ+ + LVV R RE A ++ V+ Sbjct: 168 DQLYGFNITRLYTLAARAKGYQGLLSVGRVQTPILGLVVRRCRENAAHQKTYYYLVNGQF 227 Query: 227 TTPSGEALALQVTHQND---KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 + A D + R NKE + + + ++ K + P Sbjct: 228 EVEGIQFPARYQVADGDPVDEKGRLSNKEHAEGIAAAVSGQPARIVSVTTKAKEAAAPLP 287 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISD- 341 + LQ AS + GF + + Q L E ITY R+D LS++ G ++ Sbjct: 288 YNLLKLQMDASRKFGFKPDQVKDITQALREKHKLITYNRSDCEYLSEEQHGDAPGVLAAI 347 Query: 342 -------NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 + + A + AH AI P++ L + QK+Y LI Sbjct: 348 AQTAPMLAAAAQRANPTIKSRAFNSSKVSAHHAIIPTE---STADLSKLTDAEQKIYLLI 404 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE-------- 446 R +VA YD T + GD R R + GW + ++ Sbjct: 405 ARAYVAQFWPKHLYDQTDVLAQVGDHRFGVRSNVTTSPGWKILYKNDAGNEDLEGNADDI 464 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-------------------- 486 ++ L + G A T + Q TKP ++ SL+ +L Sbjct: 465 EQDLRKLRDGQAGTCTDAKAEQQETKPQPLYTMESLLSDLTRVAKYIRDDRLRKILIEKD 524 Query: 487 -----EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYD 541 E GIG P+T SII+T+ +RGY+ + + + GE + D L + R D Sbjct: 525 KGKQGEHGGIGTPATRDSIIATLFERGYLVEKGKHIVSTPTGEELYDALPDTARF---PD 581 Query: 542 FTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPT 601 TA + E + + ++ ++ + + M + + CP+ Sbjct: 582 MTALWHEQQKAIQAGERDTLSFVNELMEYIGAEVANIKDNGL-------NMKIDTHPCPS 634 Query: 602 CGRKM--GIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAK 659 CG+ + + F GC+G+A K C E V E Sbjct: 635 CGKPLRRLKKKDKNEYFWGCTGFADGCKFACDDKGGKPVPREAPKVSE-----------L 683 Query: 660 RRCPKCGTAMDSYLIDPKRKL-HVCGNNPTCDGYEIE 695 +C CG + + C N PTC + Sbjct: 684 HKCMACGHGLSRRPGKKRGMFWWGCSNFPTCKQTYPD 720 Score = 64.0 bits (154), Expect = 3e-08, Method: Composition-based stats. Identities = 19/112 (16%), Positives = 31/112 (27%), Gaps = 7/112 (6%) Query: 685 NNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEM--HLKMGRFGKYMACTNEECKNTRKI 742 + I++ +K P C CG + K + + CT Sbjct: 609 EYIGAEVANIKDNGLNMKIDTHP---CPSCGKPLRRLKKKDKNEYFWGCTGFADGCKFAC 665 Query: 743 LRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG--VFLAANTFPKSRET 792 G P+E P C R G + + FP ++T Sbjct: 666 DDKGGKPVPREAPKVSELHKCMACGHGLSRRPGKKRGMFWWGCSNFPTCKQT 717 Score = 63.2 bits (152), Expect = 4e-08, Method: Composition-based stats. Identities = 20/109 (18%), Positives = 33/109 (30%), Gaps = 8/109 (7%) Query: 644 NVLEGEDAETNALRAKRRCPKCGTAMDSYLID-PKRKLHVCGNNPT-CDGYEIEEGEFRI 701 V +D N CP CG + C C ++G + Sbjct: 614 EVANIKDNGLNMKIDTHPCPSCGKPLRRLKKKDKNEYFWGCTGFADGCKFACDDKGGKPV 673 Query: 702 KGYDGPI---VECEKCGSEMHLKMGRFG--KYMACTN-EECKNTRKILR 744 + +C CG + + G+ + C+N CK T L+ Sbjct: 674 PREAPKVSELHKCMACGHGLSRRPGKKRGMFWWGCSNFPTCKQTYPDLK 722 >UniRef50_Q7Q111 DNA topoisomerase n=3 Tax=Endopterygota RepID=Q7Q111_ANOGA Length = 1025 Score = 456 bits (1174), Expect = e-126, Method: Composition-based stats. Identities = 159/730 (21%), Positives = 274/730 (37%), Gaps = 85/730 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVK----SSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 K L + E AKTI L + S I + + TS + Sbjct: 30 KYLNVAEKNDAAKTIAGLLSRGSSQRREGYSPYNKIYEFSYNLHGQSIQMIMTSV-SGHL 88 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEVL--PGKEKVVSELKQLAEKADHIYLATDLDREG 116 + + P ++A EK+ L++ + + TD DREG Sbjct: 89 LTHEFLPSFRGWHSCSPEDLFDAPVRKNCPEQYEKIKKTLEREVRGCSALIIWTDCDREG 148 Query: 117 EAIAWHLREVIGGDDA--RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E I + + EV R R F+EIT +I++A + + + +A R +D Sbjct: 149 ENIGYEIIEVCRAVKPQLRVFRAKFSEITAPSIKRAIENLVQPDARQNDAVNVRSELDLR 208 Query: 175 VGYMVSPLLWKKIARG---------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G + ++ + +S G Q + V +R +EI+ F+P+ FW++ + Sbjct: 209 IGAAFTRFQTLRLQKSFPQDISNNLVSYGSCQIPTLGFVAQRYKEIENFIPQTFWKIKLT 268 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLE-KARYSVLEREDKPTTSKPGAPF 284 T L ++ ++ F +K+ +A + L + V+ KP P Sbjct: 269 HTIDD---LTVEFHWSRNRLF---DKQCCEAYLMLCQTNPTAKVVNVTQKPKNKWRPTPM 322 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV--NMVRGYISDN 342 T L++ S +L K+ M +A++LY G I+Y RT++ + D +V+ ++ + Sbjct: 323 DTVELEKLGSRKLKMNAKQVMTIAEKLYTQGIISYPRTETNMFTGDMKLAPLVQAQVASD 382 Query: 343 ----FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 F +K L N K++ Q AH I P+ + ++ D ++Y+LI R F Sbjct: 383 QWGSFAEKVLQWGVNPRNGKKSDQ-AHPPIHPTKLP------TNLSGDEWRVYELIARHF 435 Query: 399 VACQMTPAKYDSTTLTVGAGDFR-LKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 +AC A T + V + A G + + +V P R ++ + + G Sbjct: 436 LACVSRDATGSETIVNVVVAEEEEFTASGLCIHERNYLEVYPYDRWNAKE--IHSYQVGH 493 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV-RVENRR 516 EL + T P +EA L+ +EK GIG +T+A I+TI++RGY+ + Sbjct: 494 TFEPTELGLHEGSTTAPNMLTEADLIALMEKHGIGTDATHAEHINTIKERGYIGERDRGF 553 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL- 575 +G + + E L + + A +E L V VL + + + Sbjct: 554 LVPGTLGMGLVEGYEMMELRLAHPELRAGLEADLKLVCEGRKNPNDVLAEQIAKYKEVYR 613 Query: 576 ---DKAEKDPEEGGMRPNQMVL--------------------TSIDCPTCGRKMGIRTAS 612 KA G R NQ CP CG KM +RT Sbjct: 614 IMSQKARALDRAMGQRLNQTPQEPPPDAGASAATATGSAPMREVCKCPKCGHKMCLRTKR 673 Query: 613 T--GVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMD 670 G +LGC + C+ I +NVL+ C +CG+ Sbjct: 674 DSSGYYLGCVAFP-----ECRNNIWFDDSMREINVLDDT------------CARCGSKKM 716 Query: 671 SYLIDPKRKL 680 + R Sbjct: 717 TVKFRSVRFY 726 Score = 43.9 bits (102), Expect = 0.027, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 12/33 (36%), Gaps = 2/33 (6%) Query: 761 LPCEKSDAYFVLRDGA--AGVFLAANTFPKSRE 791 C K LR +G +L FP+ R Sbjct: 658 CKCPKCGHKMCLRTKRDSSGYYLGCVAFPECRN 690 >UniRef50_A4I3Q5 DNA topoisomerase III, putative n=8 Tax=Trypanosomatidae RepID=A4I3Q5_LEIIN Length = 867 Score = 456 bits (1174), Expect = e-126, Method: Composition-based stats. Identities = 169/852 (19%), Positives = 294/852 (34%), Gaps = 77/852 (9%) Query: 1 MGK-ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTK----T 55 MG+ L++ E P+ A++I L + + + R LP K T Sbjct: 1 MGRNVLMVAEKPSLAESIATILSNGSCSRRT----RALPVYEYTGNFMGSPAYFKVTSTT 56 Query: 56 AKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDRE 115 D N D + A KV L+ ++ D + L D DRE Sbjct: 57 GHVFSCDFTSQHQNWDRTDEEQLFTAPITWKDTSGKVSHHLEHESQGCDTLVLWLDCDRE 116 Query: 116 GEAIAWHLREVIGG---DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 GE I + + +V+ + R F+ IT I AF G+ N + +A R+ +D Sbjct: 117 GENICFEVMQVVRREIYNHHSIFRAHFSAITAEEIFHAFRNLGKPNKNISDAVTCRQELD 176 Query: 173 RVVGYMVSPLLWKKIAR--------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 VG + K +S G Q+ + V+R EI F PE FW + Sbjct: 177 LKVGVAFTRFQTKYFQGKYGDLDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRL-V 235 Query: 225 STTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEK--ARYSVLEREDKPTTSKPGA 282 + G L + R ++ + + + K +V+ T Sbjct: 236 PVASRGGALLQFEWDR-----GRLFDETMARLILQRITKSGKVATVVNVSVSNDTRPRPT 290 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGYIS 340 T L + AS LG G M +A+ LY GYI+Y RT+ST + + Sbjct: 291 GLNTVDLMKIASRALGIGPHYVMSIAENLYIRGYISYPRTESTAYPPSFNLAGALAQQKN 350 Query: 341 DNFGKKY---LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 + Y L + + H I P + + S ++ D ++++ I R Sbjct: 351 HSMWGAYVTALLQQGHARPKAGKDAGDHPPITP----MRSASPSELSGDEWRIFEYITRH 406 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 F+A + T +T+ G G+++ G+T++MP R D DR+ V+KGD Sbjct: 407 FIASVSPDCRLIKTKITIELGGELFSISGKVVEDPGFTEIMPHARVED-DRMPTGVHKGD 465 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-NRR 516 + L ++ T+PP+ +E+ L+ +EK GIG ++ ++ ++ I +RGY V+ R Sbjct: 466 SFQLSDVRLQAGQTQPPSYLTESDLIGLMEKNGIGTDASISTHVNNIVERGYCSVQAGRV 525 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS------- 569 K+G ++ ++ EL+ +++E + +A A+ VL + Sbjct: 526 MKPSKLGIVLIHGIKAIDPELVLPLVRSRVEEYVTHIAEGRAQLDDVLSYSLDLFFAKFK 585 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG--CS-GYALPP 626 F + +D + + C C R + C +ALP Sbjct: 586 FFKEHIDVFDALMGASFSAISAAGKPITRCGNCMRYLKHLDTRPQRLYCPYCEVTFALPQ 645 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDP-----KRKLH 681 K + ++ E ++ CP C + P R Sbjct: 646 GGTIKPYSSFKCP---IDNFELVICHIEGGKSFPICPHCYNNPPFEDMRPAIQHHHRGYG 702 Query: 682 VC--------GNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN 733 + CD E + C M G++ C N Sbjct: 703 GGAAATTAPSTRHMACDECRHPTCEHSLATNYVCDCVDGSCAGSMAFVPRTAGQWKVCCN 762 Query: 734 EECKNTRKILRNGEVAPPKEDPVPLPELPC-----EKSDAYFVLRDGAAGVFLAANTFPK 788 +C K+ + + P C + + R +A Sbjct: 763 -KCPMMIKLPPTAQRVYVTFEECPECASNCLDIMFPEGKSVLPNRKDR---IVAC---IF 815 Query: 789 SRETRAPLVEEL 800 +PL EE+ Sbjct: 816 CHPGLSPLCEEV 827 >UniRef50_Q01NZ0 DNA topoisomerase n=2 Tax=Acidobacteria RepID=Q01NZ0_SOLUE Length = 1333 Score = 456 bits (1173), Expect = e-126, Method: Composition-based stats. Identities = 139/646 (21%), Positives = 249/646 (38%), Gaps = 95/646 (14%) Query: 2 GKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADS 50 G V+ E P+ A+ I + LG + YVV ++GH+ L G + Sbjct: 7 GNVAVLAEKPSVARDIARVLGAGTKGEGFLHGNGYVVTWAIGHLAALAQPGEIDPQ---- 62 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAE--KADHIYL 108 R P + V + +K++ K + Sbjct: 63 ---------------WRPWRRNTLPMLPRQWPLVVYEKTKDQFETVKRILNSPKIARVVC 107 Query: 109 ATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQ 166 ATD REGE I ++ E G + SR+ + +T +AIR+ F+ +P +A + Sbjct: 108 ATDAGREGELIFRYIYEAAGCE-KPVSRLWISSLTPDAIRKGFDALRPAADYDGLADAAR 166 Query: 167 ARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 R D +VG +S + LS GRVQ+ + ++VERE ++ FVPE++ EV A+ Sbjct: 167 GRSRADWLVGMNLSRAYSLAYSEDLSVGRVQTPTLAMLVERELTVRNFVPEDYMEVLATF 226 Query: 227 T-TPSGEALALQVTHQNDKP------------FRPVNKEQTQAAVSLLEKARYSVLERED 273 T + + Q T D+ P + E+ + + ++ + Sbjct: 227 HPTGAPKESVYQGTWFRDRVPGADKESQQQAMRLPPDGEEANRIAARARTGQAAIESIDA 286 Query: 274 KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAV 332 + P + + LQ+ A+ GF +KT+ AQ LYE I+Y RTDS +LSQD Sbjct: 287 QTQRMAPPPLYDLTELQRHANRLFGFSAQKTLDTAQALYERHKLISYPRTDSRHLSQDVA 346 Query: 333 NMVR---GYISDNFGKKYLPESPNQYAS----KENSQEAHEAIRPSDVNVMAESLKDMEA 385 + I++ + + P + + + H AI P+ V + + + Sbjct: 347 RTLPRVVAAIAEPYRELLAPGTGERPLGRRFVDDAKVTDHHAIIPT---VTSAANAQLAP 403 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD----FRLKARGRILRFDGWTKVM--- 438 D +K+Y LI R+ ++ ++ TT+ + R + G ++ GW + Sbjct: 404 DERKIYDLICRRLLSAWHEDHIWNVTTVITAIRNAAVIDRYHSSGSAVQQLGWKVLDLAP 463 Query: 439 --------PALRKGD--EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE- 487 P D E + P + G ++ + T+ P RF+E +L+ +E Sbjct: 464 AKAKRAKSPGTADADRGEQELPPGLASGQPQDVLNAEALKKKTRAPKRFTEGTLLTAMET 523 Query: 488 ---------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 + G+G P+T A+II + R Y+ + A G + + + Sbjct: 524 AGKTLDEKELSDAMKETGLGTPATRANIIEVLLKREYIVRNGKSLEATDKGVHLIEVVH- 582 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 E+ + T Q E L ++ A+ + + K Sbjct: 583 --PEVRSPIMTGQWEAYLHRIHRGNAQLDPFMHGIEEYVRDVVGKV 626 >UniRef50_Q099E1 Topoisomerase B n=1 Tax=Stigmatella aurantiaca DW4/3-1 RepID=Q099E1_STIAU Length = 1504 Score = 455 bits (1171), Expect = e-126, Method: Composition-based stats. Identities = 139/663 (20%), Positives = 249/663 (37%), Gaps = 110/663 (16%) Query: 6 VIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTK 54 V+ E PA A+ I + LG + YVV ++GH+ L Sbjct: 33 VVAEKPAVARDIARALGATQRGEGWFRGNGYVVTWAIGHLVGLAQPHE---------MHP 83 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 K+ +++ L + + N +EV+ VV+ A + + ATD R Sbjct: 84 AWKRWHREQLPMLPSTWPLVVSENTRTQFEVV---RAVVN-----APEVSGVVCATDAGR 135 Query: 115 EGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFMD 172 EGE I ++ E G R+ + +T+ AIR+ F K G +A + R D Sbjct: 136 EGELIFRYIYEAAGCR-KPVKRLWVSSLTEGAIREGFRTLKDGRAYDALADAAKGRSRAD 194 Query: 173 RVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT----- 227 +VG +S L LS GRVQ+ + ++VERE I+ FVPE++ EV A+ Sbjct: 195 WLVGMNLSRLYTLACGETLSVGRVQTPTLAMLVERELAIRDFVPEDYLEVVATFAPQAAG 254 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAA-------------VSLLEKARYSVLEREDK 274 P+G + + P E + A ++ + + + Sbjct: 255 VPAGTQYRGTWFREAEPKGGPRTAETAREARRLPADGVEAGEVMARVRSGAAVIESLTSE 314 Query: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVN 333 P + + LQ+ A+ GF ++T+ +AQ LYE ++Y RT S +LS Sbjct: 315 TKRMAPPLLYDLTELQRHANRLYGFSAQRTLELAQNLYEKHKLLSYPRTASRHLSSAVAE 374 Query: 334 MVRGY---ISDNFGKKYLP----ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEAD 386 + I + P + + + H AI P+ + E + D Sbjct: 375 TLPEVVRAIRAPYEPLLAPGTGEKPLGRRFVDDAKVTDHHAIIPTATSPEGE---RLPPD 431 Query: 387 AQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF----------RLKARGRILRFDGWTK 436 ++LY+L+ R+ +A + TT+ R + G + GW Sbjct: 432 EKRLYELVCRRLLAAWHDEHVWAVTTVVTAVSSVGPAPGSPRVDRFHSSGTQVVRVGWKV 491 Query: 437 VM--------------------PALRKGDEDRILPA-VNKGDALTLVELTPAQHFTKPPA 475 + DE + LPA + +G + ++ + T+PP Sbjct: 492 LDIGGGQRPPKGREGKGPKEEGEGKEPEDEPQDLPAVLARGQKQRVEDVEAVKKRTRPPP 551 Query: 476 RFSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 R ++ASL+ +E + G+G P+T A+II + +R Y++ + Sbjct: 552 RLTDASLLTAMETAGRTLDEKELADAMKETGLGTPATRAAIIEVLLEREYLQRRGKSLEV 611 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 + G + + ++ T Q E L ++ + + +A L + + + K Sbjct: 612 TEKGIRLIQVVH---PDVKTPAMTGQWEAWLQRIERGQGDLQAFLRGIEAYVIEVVGKMP 668 Query: 580 KDP 582 P Sbjct: 669 AQP 671 >UniRef50_D1W4E5 DNA topoisomerase n=30 Tax=Bacteroidales RepID=D1W4E5_9BACT Length = 714 Score = 455 bits (1171), Expect = e-126, Method: Composition-based stats. Identities = 148/693 (21%), Positives = 258/693 (37%), Gaps = 73/693 (10%) Query: 6 VIVESPAKAKTINK-----------YLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTK 54 +I E P+ A+ I + + G Y V + GH+ L + + Sbjct: 23 IIAEKPSVAREIARIVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGVRGFVRDNLP 82 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 + G Y+ G + +K+L + ++HI +ATD R Sbjct: 83 IIPDTFTLVPRQVRTEKG----------YKPDSGVVSQIKVIKRLFDTSEHIIVATDAGR 132 Query: 115 EGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRFMD 172 EGE I +L G R+ + +T AIR+ K + + A +AR D Sbjct: 133 EGELIFRYLYHYTGCTTPFV-RLWISSLTDKAIREGLRKLEDGSKYDNLYLAAKARSESD 191 Query: 173 RVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 +VG + L G S GRVQ+ + +V ER E + F E FW + +T G Sbjct: 192 WLVGINGTQALSIAAGHGTYSVGRVQTPTLAMVCERYWENRRFTSEAFWLLHIATDGCDG 251 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKA-RYSVLEREDKPTTSKPGAPFITSTLQ 290 E + + + + KE + ++ A +V + E K T + + +TLQ Sbjct: 252 EVVKFSSSEKWKE------KEPAMELYNKVKAAGCATVTKAERKEKTEETPLLYDLTTLQ 305 Query: 291 QAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS----DNFGKK 346 + A+ + GF ++T+ +AQ+LYE ITY RT S + +D + ++ K Sbjct: 306 KEANAKHGFTAEQTLEIAQKLYEKKLITYPRTGSRYIPEDVFAEIPKLLAFIGTQPEWKD 365 Query: 347 YL--PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMT 404 + +P + + + H A+ + E + + +YQ+I + V Sbjct: 366 KVRAKAAPTRRSVDDGKVTDHHALLVTG-----EKPLFLSKEDNTIYQMIAGRMVEAFSE 420 Query: 405 PAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 464 D TT+T +G +++ GW V + E+ +P +GD LT Sbjct: 421 KCVKDVTTVTAECAGVEFTVKGSVVKQTGWRAVYGEEK---EEITIPGWQEGDTLTPKGS 477 Query: 465 TPAQHFTKPPARFSEASLVKELEKR----------------GIGRPSTYASIISTIQDRG 508 + + TKP +EA+L+ +E GIG P+T ASII T+ RG Sbjct: 478 SITEGKTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDCGIGTPATRASIIETLFKRG 537 Query: 509 YVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 Y+ + + G + ++ + + T + E L ++ E Sbjct: 538 YMERCKKSLVPTEKGLALNSVVKTM--RIADVAMTGEWEKELARIERGELSADTFRKEIE 595 Query: 569 SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALP-PK 627 + + + + G R + CP CG R G + C P Sbjct: 596 AYTREITSELLSCDKLFGSRD-----SGCACPKCGTG---RMRFYGKVVRCDNTECGLPV 647 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKR 660 R K L + + EG ++K+ Sbjct: 648 FRLKAGRTLSDDEIKDLLTEGHTKLLKGFKSKQ 680 >UniRef50_C6XWV5 DNA topoisomerase type IA central domain protein n=2 Tax=Pedobacter RepID=C6XWV5_PEDHD Length = 608 Score = 455 bits (1170), Expect = e-126, Method: Composition-based stats. Identities = 147/619 (23%), Positives = 248/619 (40%), Gaps = 64/619 (10%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 +VI E P+ + + K G Y + GH+ L Sbjct: 2 KIVIAEKPSVGRELAKVFGATTKKDGYIEGKGYSFTWAFGHLLQLAPPQEYG--FIGWRR 59 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 PKK + + + PG K + +K+L ++A I +ATD Sbjct: 60 QHLPMLPKKFKLAIRKIKTKDGMVED--------PGVRKQLDIIKKLFDEATEIIVATDA 111 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRF 170 REGE I ++ + + R+ + T AI++ F PG N+ R Sbjct: 112 GREGELIFRYIYYFLKC-KKPFRRLWISSQTDEAIKEGFRNLKPGTDYDTLFNSAHCRSE 170 Query: 171 MDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D +VG + L LS GRVQ+ + ++ R EIK FVP+ ++++ Sbjct: 171 SDWLVGMNATQALSISAGNRSVLSLGRVQTPTLAMICSRFLEIKNFVPQTYYQLAIQLDK 230 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 A+ V++ + K + + S +L E KP P S+ Sbjct: 231 DGQLFRAMSVSNFDKKEEAEELLAKIEDVASGFSNG-GKILSVEAKPRKEPPPLLHDLSS 289 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS-----DNF 343 LQQ A+ R GF +T+ + Q LYE+ +TY RT S + D V I +F Sbjct: 290 LQQEANKRKGFTADQTLSLLQGLYESKLVTYPRTGSRYIGDDIFAGVPALIDKVRGHKDF 349 Query: 344 GKK---YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 GK+ L N+ + H AI P+ ES + D Q +Y ++ + + Sbjct: 350 GKQAEFLLTVPLNKRSVNAKKVTDHHAILPTG-----ESPYQLNGDKQAVYDMVVGRMIE 404 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGD 457 + T ++V +G A G ++R GW V +K +++ LP + KG+ Sbjct: 405 AFHQECVKEITKISVESGSL-FIANGTVIRAAGWRSVFNESDEEKKDEDNPALPKLKKGE 463 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVK----------------ELEKRGIGRPSTYASII 501 L + + TKP A ++EASL+K ++ G+G P+T A+II Sbjct: 464 ELPVTNKALLEKQTKPKAMYNEASLLKALETSGKDIEDEELRYAMKDSGLGTPATRAAII 523 Query: 502 STIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHE--AE 559 T+ R YV E R G V D +++ +++ + T Q E L+++ + ++ Sbjct: 524 ETLISREYVSREKRNLVPTTKGLAVYDVVKD--QKIAQAELTGQWEKRLEEIRSGASVSD 581 Query: 560 WKAVLDHFFSDFTQQLDKA 578 +KA + + T +L A Sbjct: 582 FKAEIADYTKTITNELLAA 600 >UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina EX-H1 RepID=C0QUY8_PERMH Length = 834 Score = 454 bits (1168), Expect = e-126, Method: Composition-based stats. Identities = 152/642 (23%), Positives = 290/642 (45%), Gaps = 64/642 (9%) Query: 4 ALVIVESPAKAKTINKYLG------------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 L+I E P+ A K + +Y + +VGH+ ++ Sbjct: 2 KLIIAEKPSVAIDTAKAISPKFQKKDGYIEAGEYTITWAVGHLLEI-------------- 47 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATD 111 D ++ P + Y+V GK K + +K L +KAD I++ TD Sbjct: 48 ---------DDTIAPKEWKLETLPILPEKFEYKVSKGKNKQFNIVKSLVKKADEIFVNTD 98 Query: 112 LDREGEAIAWHLREVIGGDD-ARYSRVVFNE-ITKNAIRQAFN--KPGELNIDRVNAQQA 167 REGE IA + G + + R +E +TKN I + KP + + A Sbjct: 99 AGREGELIARLILLYSGWNGWDKTYRFWTSEALTKNVILRELKARKPAKNWDSLFYSGLA 158 Query: 168 RRFMDRVVGYMVSPLLWKKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 R+ D +VG ++ L + G S GRVQ+ ++L+VER+ EIK F P+ +W+++A Sbjct: 159 RQQSDWLVGINLTRALTVIVGDGSVWSIGRVQTPVLKLIVERDLEIKNFKPKPYWQLEAV 218 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 S + ++ ++ D F NK + +L +K + V E E K F Sbjct: 219 FEKDS-QKFKAKLLNEKDTIFEDKNK-IWEIFKALKDKDKAVVKEIEKKQHKKYAPPLFS 276 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD--AVNMVRGYISDNF 343 +TLQ A+ R GF +KT+M+AQ LYEA YI+Y RT++ +L ++ ++V+ + Sbjct: 277 ITTLQMTANKRFGFTAQKTLMLAQDLYEAKYISYPRTEAQHLDENPSTKDLVKNILKKLG 336 Query: 344 GKKYLPE--SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVA 400 ++ + + + H AI P ++ ++ K+ + D K+Y+LI +F+A Sbjct: 337 EEQLIENVDKVGKRVFDSSKLTDHYAIIPMNLLTEEKAKKEGLNQDHLKIYELIKNRFLA 396 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALT 460 M P +Y++T + ++ A G++ GW + + LP + KGD + Sbjct: 397 VFMPPYEYETTKAILDIDGYQFTASGKVELSLGWKAIDREDEDDKIEAPLPQLEKGDMVH 456 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 + + TKPPA ++E++L+ ++++ +G +T A II T++DR Y++ + + A Sbjct: 457 KISQRVIEDKTKPPAHYTESTLLNKMKQLELGTGATRAGIIQTLKDRFYIKNKGKSLIAT 516 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN---HEAEWKAVLDHFFSDFTQQLDK 577 + G + +++++ +E + T++ E L+Q+ + ++ L+ ++++ Sbjct: 517 EKGFALIEKIKD--KEFASPKMTSKWEQQLEQIYTQKLGKKGYEDFLNQIKEFTKKEVEA 574 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC 619 + + +P + CG + G + C Sbjct: 575 VKGISIQMEQKP-------VGRCRCGGDVF----EYGKYYQC 605 >UniRef50_Q9KQF5 DNA topoisomerase 3 n=109 Tax=Gammaproteobacteria RepID=TOP3_VIBCH Length = 647 Score = 454 bits (1167), Expect = e-126, Method: Composition-based stats. Identities = 134/649 (20%), Positives = 248/649 (38%), Gaps = 86/649 (13%) Query: 5 LVIVESPAKAKTINKYLGSDY-------------VVKSSVGHIRDLPTSGSAAKKSADST 51 L I E P+ A+ I L + +V +GH+ + + ++ Sbjct: 4 LFIAEKPSLARAIADALPKPHKKEQGCIRCANGDIVTWCIGHLLEQVEPDAYDERYKKWN 63 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATD 111 P+ + + ++ +++L ++A I A D Sbjct: 64 MADLPIIPE-------------------QWQLRPRKSSSQQLTVVRKLLKEATQIIHAGD 104 Query: 112 LDREGEAIAWHLREVIGGDDAR---YSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQ 166 DREG+ + + + ++ R++ +++ +A+++A I + Sbjct: 105 PDREGQLLVDEVIDYCKVPKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVSAL 164 Query: 167 ARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 AR D + G +S + LS GRVQ+ + LVV R+ EI+ F+P +++ Sbjct: 165 ARSRADWLYGMNMSRAYTLLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDYFT 224 Query: 222 VDASTTTPSG-EALALQVTHQ--------NDKPFRPVNKEQTQAAVSLLEKARYSVLERE 272 +DA +G E ++ + D+ R N++ S + +V E E Sbjct: 225 LDALIPYQNGTEYFDIRARWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTESE 284 Query: 273 DKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDA 331 T P+ S LQ A+ R F ++ + + Q LYE ITY R+D L ++ Sbjct: 285 QDQTKQAAPLPYSLSALQIDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLPKEH 344 Query: 332 VNMVRGYIS--DNFGKKYLPE------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDM 383 + ++ N ++ + S A ++ +AH AI P+ S+ + Sbjct: 345 LAQAPDVVAAIANNAQEMVTAVNDADLSLRSKAWNDSKVDAHHAIIPT---PKKASVNAL 401 Query: 384 EADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRK 443 K+YQLI RQ++ A Y L A+GR L GW KV+ + Sbjct: 402 SGHEMKVYQLIARQYLMQFYPAAIYAEAKLVFNIAGGIFIAKGRQLLSAGW-KVLTGQQD 460 Query: 444 GDED--RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL--------------- 486 E+ +P + G L E Q T+PP F+EA+L++ + Sbjct: 461 EQEECVDKVPPLPVGIVLQCREGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKKI 520 Query: 487 --EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTA 544 E G+G +T A I+ T+ RG ++ +N+ + G + L E D TA Sbjct: 521 LRETDGLGTEATRAGILDTLFKRGLLQRDNKLIKSTPAGRGLIHALP---SEATYPDMTA 577 Query: 545 QMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMV 593 E+ L +A ++ + Q +++ + P ++ V Sbjct: 578 HWEHQLQAIAEKGQAYQPFMQTLQGRLEQLIEQVQVAPVPVSLQALPAV 626 >UniRef50_B0ERJ9 DNA topoisomerase n=2 Tax=Entamoeba RepID=B0ERJ9_ENTDI Length = 840 Score = 454 bits (1167), Expect = e-126, Method: Composition-based stats. Identities = 171/832 (20%), Positives = 308/832 (37%), Gaps = 84/832 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVK------SSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 L++ E P A++I +L V S H + G K S + Sbjct: 4 LMVAEKPLLAESIANFLSLGPVKTRKGIAPSCPVHEFNCKFKGKITKAKMTSVAGHVY-- 61 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEVLPG--KEKVVSELKQLAEKADHIYLATDLDREG 116 E VDP + + K + S L+ A+ + + L D DREG Sbjct: 62 --TCEFERAFQNWSVDPRDLFNCKVIKVEANPKTHIPSHLRNEAKGCNGLVLWLDCDREG 119 Query: 117 EAIAWHLREVI---GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 E I + + E + R +F+ ITK I +AFN G+ + A R+ +D Sbjct: 120 ENICFEVMENTVDYMTKTCKIYRALFSSITKKDITEAFNHLGQPDERLAEAVDCRQEIDL 179 Query: 174 VVGYMVSPLLWKKIARG--------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 VG + L K + +S G Q+ + V+R++EI FV + F+ + Sbjct: 180 RVGVAFTRLQTKFLKERFPKLGDSLISFGPCQTPTLGFCVDRQKEIDNFVSKPFYTLKVI 239 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 G L++ D NK V + + V++ Sbjct: 240 LEDHEGRNKTLKLDKCFD------NKSDVDDIVKSCKGVQGKVIKMNVNELKKSRPIGLN 293 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLS-----QDAVNMVRGYIS 340 T + +AAS +LG G + TM +A++LY GYI+Y RT+ST S D +N ++ Sbjct: 294 TVEMLKAASIKLGLGPQDTMRIAEKLYTRGYISYPRTESTKYSSYFNFDDILNNLQETNQ 353 Query: 341 DNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 + + ++ + H I P +N E L D +KL+ I F+A Sbjct: 354 FREKVQLVKQNGINIPRNGEDKGDHPPITP--LNYPNEYLND---SEKKLFDFITNTFLA 408 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE----DRILP-AVNK 455 + + +++ G++ G++L+ G+ K++ + +E D I P + + Sbjct: 409 SIYKDSIFQKVNVSIQIGNYTFNGSGKVLKDPGFKKIISRYDEDEEIKDSDLIKPTSFIE 468 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-- 513 GD + + T P +E L+ +EK GIG ++ I I R YV ++ Sbjct: 469 GDIVIPSMFDIVKGMTTCPDYLTEYELISLMEKNGIGTDASIPVHIQNIITREYVSLDTS 528 Query: 514 NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ 573 R K+G + LE + L+ A +E+ + ++A +A+++ VL+ F Q Sbjct: 529 KRTLRPTKIGLALAKTLETVDKNLITPQIRAHIESMVSRIAEGKAQYENVLEEALDTFEQ 588 Query: 574 Q---LDKAEKDPEEGGMRPNQMVLTSIDCPTCGR--KMGIRTASTGVFLGCSGYALPPKE 628 + K EE Q+ S CG+ ++ ++ +L C +L K Sbjct: 589 NYLIYKQNLKVLEENFAPLYQVQEQSRLFSKCGKCGRILLKVIGDQTYLSCPNCSL--KF 646 Query: 629 RCKTTINLVPENEVLNVLEGEDAETNALRAKRR---CPKCGTAMDSYLIDPKRKLHVCGN 685 ++ + + + + E T++L++ ++ CP C + ++ C N Sbjct: 647 NLPQNVSYSQQTKCCPICKFETIMTSSLKSTKKEMVCPGCYNEKNQFMKQEHSSCLQCSN 706 Query: 686 NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRN 745 P C + C CG M L + C C + + + Sbjct: 707 -PECK----------LSYERTKTCLCSVCGGVMCLSSLQNKWSCFCN--TCDSHMEWIDT 753 Query: 746 GEVAPPKEDPVPLPEL---------------PCEKSDAYFVLRDGAAGVFLA 782 + A P ++ + C D+ VF + Sbjct: 754 IKKALPNDEICGKCKTYHLVDLTMKDNTVIKGCMNCDSTIKKLYTIKAVFYS 805 >UniRef50_B6ADG7 DNA topoisomerase n=1 Tax=Cryptosporidium muris RN66 RepID=B6ADG7_9CRYT Length = 857 Score = 454 bits (1167), Expect = e-126, Method: Composition-based stats. Identities = 162/833 (19%), Positives = 305/833 (36%), Gaps = 66/833 (7%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKS-SVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 L++ E P+ A+T+ K L + + + + T+ K++ ++ + + Sbjct: 29 PTVLMVAEKPSIAETVAKVLSNGNLNTRQCKTPVHEY-TAYFQHKRALFKVTSVSGHVFE 87 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 D N +DP ++ K+++ L + A+ D + L D DREGE I Sbjct: 88 TDFPSKYSNWESIDPVDLFDLPTVKNESSSKMIAHLLREAKNCDFLVLWLDCDREGENIC 147 Query: 121 WHLREVIGGDDAR-------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 + + V+ A+ R F+ + + +A N N D +A R+ +D Sbjct: 148 FEVISVVKDVMAKGRNESLWIFRARFSSVAPKDVIEAMNNLKSPNRDEADAVDVRQELDL 207 Query: 174 VVGYMVSPLLWKKIARG--------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G S + LS G Q+ + VV+R +I F PE+F+ ++ + Sbjct: 208 KIGVAFSRFQTTYLKTKYGDFNNSILSYGPCQTPTLFFVVQRRDKILGFSPEKFYYLNVT 267 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 + + L T + K F + + V+ V++ + K P Sbjct: 268 IEY---KDIILSPTWERKKIFDLQSIQCLYNTVNSTYPIIAKVIDIKKKADRISRPLPLN 324 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLS-----QDAVNMVRGY-I 339 T + + AS LG + M +A++LY +G+ITY RT++T ++A ++ + + + Sbjct: 325 TVQMLKLASNILGISPFQAMNIAEKLYLSGFITYPRTETTKYPKSFDTKEAASIHKDHPL 384 Query: 340 SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFV 399 + L + H I P + D+ D +LY+LI R F+ Sbjct: 385 WGQYTCDILARNYTNPRQDGIDVGDHPPIVPIRSVIS----NDLAGDNWRLYELITRHFL 440 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 A K+ + + + +GR + G++ + + K +P ++ G L Sbjct: 441 ATISPDIKFTNEFVIFDINGEKFTLQGRRINEYGFSIIYKS--KSINSISIPQLDLGMKL 498 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR-VENRRFY 518 L + TKPP SE +L+ +EK GIG ++ I + +R YV ++ R+ Sbjct: 499 NLKSIEICNGETKPPPLLSEGNLLSLMEKNGIGTDASMPVHIQKLIERKYVNIIDGRKLE 558 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS-------DF 571 ++G + EL+ ++ME + ++ +A VL H + F Sbjct: 559 PTRLGNALIHGYMNIDIELVYPMIRSEMERYISLISQGKANAGNVLKHTLAIFKLKFLFF 618 Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCK 631 + + E + + C C R M + + L CS + K Sbjct: 619 VKNITSFESLFQLSFTNLSSSGTRLSKCGQCKRYMTYISNTNPPKLYCSFCEINLKLPSG 678 Query: 632 TTINLVPENEVLNVLEGEDAETNALRAKR---RCPKCGTAMDSYLIDPKRKLHVCGNNPT 688 ++ L E + + + E N+LR K+ CP+C C +PT Sbjct: 679 GSLKLYKELK-CPLDDYELLVFNSLRTKKNMILCPRCYNDPPFDSAIQNILCKECP-HPT 736 Query: 689 CDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKY-MACTNEECKNTRKILRNGE 747 C P+ +C+ + L + + + C+N C K Sbjct: 737 CPHSYNSSFIMY-----CPVEKCK--DGVLTLDLSSAPNWRIDCSN--CNFVLKFREK-- 785 Query: 748 VAPPKEDPVPLPELPCEKSDAYFVL--RDGAAGVFLAANTFPKSRETRAPLVE 798 V C A +L + + P E L+E Sbjct: 786 ----HCHKVSTTNDYCNNCGARILLINLNSPKESIIGC---PICLERINELIE 831 >UniRef50_C6BT42 DNA topoisomerase type IA central domain protein n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BT42_DESAD Length = 720 Score = 454 bits (1167), Expect = e-126, Method: Composition-based stats. Identities = 158/747 (21%), Positives = 278/747 (37%), Gaps = 84/747 (11%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSG----SAAKKSADSTSTKTAKKPK 60 L I E A I++ LG D PT + + + P+ Sbjct: 3 LFIAEKRDVALAISQALGGP-----------DRPTGAAFQVNGDRITWLWGHVLRLTDPE 51 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + + + + P W Y + ++ +LA +AD + A D D EG+ + Sbjct: 52 EHDERYKLWDLNTLPMK-WPVTYAPESKHVDHLKKIIELAHQADELVNAGDPDPEGQRLV 110 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQARRFMDRVVGYM 178 + E G + R++ N+ +AI +A + AR D+ GY Sbjct: 111 DEVIEFAGLLEKPTKRLLINDNNGSAILKALKNMENNSKYHGLSMSALARAVCDQRYGYN 170 Query: 179 VSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA 233 ++ K LS GRVQ+ + LVV R+R + + + V A PS Sbjct: 171 LTRCYSTLAQKKGYQGVLSVGRVQTPILGLVVARDRAHEGHEKQAYHTVKAQIDMPSQLV 230 Query: 234 LALQVTHQN---DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 A + + D+ R + + + ++ +VL + + P P+ LQ Sbjct: 231 EAEYIPADDAPVDEKGRIADAVFGKKIANEVQGQPATVLSVQTSERKNDPPLPYNLLALQ 290 Query: 291 QAASTRLGFGVKKTMMMAQRLY-EAGYITYMRTDSTNLSQDAVNMVRGYISD---NFGK- 345 A+ + KK + + QRL + ITY R+D L+ + + FG Sbjct: 291 ADAAGLWNYKPKKVLEITQRLRDQHKAITYNRSDCRYLNDERHAEAPELLQALTPAFGDM 350 Query: 346 -KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMT 404 +Y + A AH AI P+ + L + D +++Y LI + ++A Sbjct: 351 AEYAAPNLKSKAFNSKKVTAHHAIIPT---MNVPELGKLNEDERRIYTLIVKLYIAQFYL 407 Query: 405 PAKYDSTTLTVGAGDFRLKARGRILRFDGWT----KVMPALRKGDEDRILPAVNKGDALT 460 PA++ +T + + + KA GR+ GW + + K ++ L + + D+ T Sbjct: 408 PAEFVATKVELKIAGHKFKAEGRLNSSPGWRLLDEQYLKDYEKAEKQPELHKLQQNDSGT 467 Query: 461 LVELTPAQHFTKPPARFSEASLVKEL-------------------------EKRGIGRPS 495 + + FTKPPAR++ SL+K+L E GIG P+ Sbjct: 468 VESAESVKSFTKPPARYTMKSLLKDLTSVAKYVTDPEIKKLFMDKDSDKQDESGGIGTPA 527 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 T S I T+ RG+V ++++ + ++G D L E + D TA Q+ Sbjct: 528 TRDSHIETLFRRGFVAEKSKKVISTELGREFHDALPEFA---VKPDMTALWHEKQKQIEA 584 Query: 556 HEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGI-RTASTG 614 E + +++ Q++ + +++ + +++ CP C R G Sbjct: 585 GELNYLQLIEEVDGSVAQEIARVKREGI-------NIKSSAVQCPKCKTGFLKPRKGPKG 637 Query: 615 VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLI 674 F GCS Y C T P L+ + A+ A + +CP CG + Sbjct: 638 KFWGCSAYP-----DCNATF---PNKAGKPDLKAKPAKKLAASKEHKCPDCGKGLIRRPA 689 Query: 675 DPKRKL-HVCGNNPTCDGYEIEEGEFR 700 K C P C +E Sbjct: 690 KRKGLFWWSCSGFPECKFRCFDEKGKP 716 Score = 67.4 bits (163), Expect = 2e-09, Method: Composition-based stats. Identities = 17/88 (19%), Positives = 31/88 (35%), Gaps = 6/88 (6%) Query: 709 VECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKIL--RNGEVAPPKEDPVPLPELPCE 764 V+C KC + + G GK+ C+ +C T + A P + E C Sbjct: 619 VQCPKCKTGFLKPRKGPKGKFWGCSAYPDCNATFPNKAGKPDLKAKPAKKLAASKEHKCP 678 Query: 765 KSDAYFVLRDGAAG--VFLAANTFPKSR 790 + R + + + FP+ + Sbjct: 679 DCGKGLIRRPAKRKGLFWWSCSGFPECK 706 Score = 47.0 bits (110), Expect = 0.003, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 20/49 (40%), Gaps = 3/49 (6%) Query: 747 EVAPPKEDPVPLPE--LPCEKSDAYFVL-RDGAAGVFLAANTFPKSRET 792 E+A K + + + + C K F+ R G G F + +P T Sbjct: 603 EIARVKREGINIKSSAVQCPKCKTGFLKPRKGPKGKFWGCSAYPDCNAT 651 >UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU08_GEOTN Length = 706 Score = 453 bits (1166), Expect = e-125, Method: Composition-based stats. Identities = 155/732 (21%), Positives = 292/732 (39%), Gaps = 87/732 (11%) Query: 4 ALVIVESPAKAKTIN---------KYLG--------SDYVVKSSVGHIRDLPTSGSAAKK 46 +++ E P +A+ + +L + V ++GH+ +L Sbjct: 2 IVILAEKPDQARKLASPFPHTKGNGFLSIQSCKEFPNGATVTWAIGHLVEL--------- 52 Query: 47 SADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHI 106 K+P++ + P + Y+V K K +K+L ++AD I Sbjct: 53 ----------KEPEEYRPEWKKWDLATLPIIPGQFEYKVSKDKAKQFQTVKKLLKEADEI 102 Query: 107 YLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNA 164 +ATD REGE IA L + G R R + +T+NAIR+ F K G+ I + Sbjct: 103 IIATDPAREGENIARLLILMAGCSKKRIKRFWTSSLTENAIRKGFAELKDGKETIHLFHE 162 Query: 165 QQARRFMDRVVGYMVSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEF 219 QAR+ D +VG S L K I S GRVQ+ ++L+ +R++EI+ F PE F Sbjct: 163 AQARQIADWLVGMNASRLYTLLLQQKGIRDVFSVGRVQTPVLKLIYDRQKEIEQFRPEPF 222 Query: 220 WEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSK 279 +E++ T +G ++ + P + + + + + + + Sbjct: 223 YELEGQFTVKNGTYRG-KLNKRFSSP-DELYEAVSPDITKEQQTYQAVIKSVRISEKRTP 280 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYI 339 STLQ + F K + + Q LYE GY++Y RTDS ++++ ++ ++ Sbjct: 281 APKLHSLSTLQSKLNRTKKFSPTKVLELVQSLYEKGYVSYPRTDSQYITEEEYTYLQKHV 340 Query: 340 SDNFGK------KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 D + + P++ H AI P++ ++ + +D +++Y Sbjct: 341 -DQYQQCLGIHVPIRSLQPSKRYVNPEKVSDHYAIIPTEKVPDTKAFETFSSDEKEVYYE 399 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED----RI 449 I + +A MT YD T + G +GR + GW + + + + I Sbjct: 400 ILKSALAMFMTDYVYDETVIITSVGKQEFVTKGRTEKEMGWKALYQNEKDEESEGEQVAI 459 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR-----------------GIG 492 LP V +G++ +++ Q T+PP +++ L+ ++ G+G Sbjct: 460 LPEVKEGESAK-ADISVKQGMTQPPKPYTQGQLITLMKTAGKYVEDQEMKEALNQVEGLG 518 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 +T A+II T+ R + V+ + + K GEI+ + ++ L + TA+ E L + Sbjct: 519 TEATRAAIIDTLIQRRLIEVKKNQVFVTKKGEILCEAVKGTI--LSKPEMTAKWELFLQE 576 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEKDPE----EGGMRPNQMVLTSIDCPTCGRKMGI 608 + + ++ + +A +D E + + + T CP C + + Sbjct: 577 IGKGNRSKEVFIEQAKKLCYALIQQASQDVERIDAKQALEEIKKENTIAPCPRCQKGYIV 636 Query: 609 RTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 F GC+ YA CK T + + + K + K Sbjct: 637 ---DRKTFYGCTEYA----NGCKQTFPKSILGKTITKTHVKQLCEKGKTNKIKGFKGKKT 689 Query: 669 MDSYLIDPKRKL 680 D+YL K ++ Sbjct: 690 FDAYLTLQKGEI 701 >UniRef50_B1L5U0 Reverse gyrase n=2 Tax=Archaea RepID=B1L5U0_KORCO Length = 1085 Score = 452 bits (1163), Expect = e-125, Method: Composition-based stats. Identities = 161/608 (26%), Positives = 258/608 (42%), Gaps = 81/608 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSD----------YVVK---------SSVGHIRDLPTS-G 41 AL IVESP+KA+TI + G Y V +S GHI DL T+ G Sbjct: 524 KTALFIVESPSKARTIASFFGRPSRRFLDGLMAYEVTTGDYVLTIVASGGHIVDLTTTMG 583 Query: 42 SAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAE 101 D T K R D L VV L++L+ Sbjct: 584 YHGVLIEDGTYVPAYTSIK---RCNSCGHQFTDMDRCPRCGSTDLRDSRSVVESLRRLSF 640 Query: 102 KADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDR 161 +A + + TD D EGE IAW + ++I R F+E+TK AI +A +N Sbjct: 641 EASRVIIGTDPDTEGEKIAWDIYQLIMDSSGEIYRAEFHEVTKRAIIEALKSLRGINERM 700 Query: 162 VNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 V AQ RR DR +G+ +S + K+ R LSAGR Q+ + V++R RE + Sbjct: 701 VEAQIVRRVEDRWIGFELSAEVQKRFGKRNLSAGRAQTPVLGWVIDRYREHQN------- 753 Query: 221 EVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 + G+ L L+V + + ++ + E + + KP Sbjct: 754 --KKVVSIIKGDGLLLRVDGRVGEEG----------------ASKIWIRELKIEEEVVKP 795 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS 340 PF T + A+ L TM +AQ L+E G ITY RTDS +S + + Sbjct: 796 PPPFTTDAMIGEANRVLRMSANMTMQLAQFLFETGLITYHRTDSPRVSDAGFRVASLVLG 855 Query: 341 DNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAE----------SLKDMEADAQKL 390 ++F K AHE IRP+ E +++ + D +L Sbjct: 856 EDF-----------VPRKWGEGGAHECIRPTKPLSAKELIDYVKEGIIAVEGLSKDHIRL 904 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRIL 450 Y LI+R+F+A Q +V G+ + + GW P L + Sbjct: 905 YDLIFRRFIASQSRDGTLVKQVASVRVGESEFEVTRLVEARGGWIDWYPFLHITE----- 959 Query: 451 PAVNKGDALTLVELTPAQHFTKPP-ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 P + +G ++E H T P +++++LV +++RGIGRPSTYA+I+ I RGY Sbjct: 960 PRLKEGMVDVIIE-----HQTVPSVPLYTQSNLVALMKERGIGRPSTYATIVEKILQRGY 1014 Query: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 V N++ K+G V + L + F +L++ + T +E +D + A+++ ++D + Sbjct: 1015 VIERNQKLIPTKLGIEVYNFLRDRFPDLISEERTRTLERKMDSIEEGAADYQELIDELYK 1074 Query: 570 DFTQQLDK 577 + +++ K Sbjct: 1075 EIREKIGK 1082 >UniRef50_Q9U286 DNA topoisomerase n=3 Tax=Bilateria RepID=Q9U286_CAEEL Length = 855 Score = 452 bits (1163), Expect = e-125, Method: Composition-based stats. Identities = 174/886 (19%), Positives = 307/886 (34%), Gaps = 120/886 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSD---------------------------YVVKSSVGHI 34 L++ E P A +I L + + V S+ GH+ Sbjct: 3 PTVLMVAEKPLLADSIANLLSNGQAKKRKGWNGVCSVSEYDGQFNGRAARFKVTSTCGHV 62 Query: 35 RDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPG--KEKV 92 L D N VDP + A + + K K+ Sbjct: 63 MSL------------------------DFPPKFNNWERVDPAELYSAPTQRIEANPKMKM 98 Query: 93 VSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDAR--------YSRVVFNEITK 144 L A+ AD + L D D+EGE I + + + + + R F+ IT+ Sbjct: 99 NEFLASEAKNADFLVLWLDCDKEGENICFEVIDAVKCAMFKNRQDFMSDVYRAHFSAITE 158 Query: 145 NAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI--------ARGLSAGRV 196 I+ A G + + ++ AR+ +D +G + K + +S G Sbjct: 159 KDIKAAMRNLGRPDQNMSHSVDARQELDLRIGCSFTRFQTKFFQGKYGDLDSNVISYGPC 218 Query: 197 QSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQA 256 Q+ + V R +I F PE++W + + TT + Q + F + E + Sbjct: 219 QTPTLGFCVTRHDQIVQFKPEQYWVLKTNFTTSD-DGQIFSPEWQRGRIF---DAEVARV 274 Query: 257 AVSLLEKARYS-VLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG 315 V ++K VL+ K + T L + AS+ LG TM +A+ LY G Sbjct: 275 FVDRIKKCHTGLVLDVSKKEARKERPCALNTVELMRVASSSLGMSPSTTMHVAEALYTQG 334 Query: 316 YITYMRTDSTNLSQDA--VNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDV 373 YI+Y RT++T S + ++ D + + + H I P Sbjct: 335 YISYPRTETTAYSANFDLTGTLKILAGDRKWGSVVLADGIKRPKSGVDKGDHPPITPMR- 393 Query: 374 NVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDG 433 + + D ++Y+ + + FVA M Y+ TT+ + GD + +G+ + G Sbjct: 394 ----PNHGGLSGDMSRIYEYVSQHFVATLMKQCVYEVTTVKMSCGDEQFTLQGKNVVEPG 449 Query: 434 WTKVMPALRKGDEDRILPAVNK-GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIG 492 +T VMP L +E + ++ + G + L T PP +EA L+ +EK GIG Sbjct: 450 FTAVMPWLSVEEECSVPKSLQQIGAKIELQNAEIQARETTPPGYLTEAELITLMEKHGIG 509 Query: 493 RPSTYASIISTIQDRGYVRVE-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 ++ I+TI R YV VE RR ++G+ + + EL+ A++E L+ Sbjct: 510 TDASIPVHINTITQRNYVTVESGRRLVPTRLGQCLVRGYWKVDPELVLPTMRAELEEQLN 569 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 VA+ +A++ +F F ++ + C C R M + Sbjct: 570 LVASGKADYLD--RNFEKKFL--IENFIFFKTFFVEKNENTGKPFSRCGKCRRYMKLVQT 625 Query: 612 STGVFLG--CSG-YALPPKER--CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 C YA+P + K + + +V+ + R CP C Sbjct: 626 KPQRLYCPTCQETYAVPNFKDGVLKVIGDHKCPLDDFDVILYQGPGGKLARTFTLCPFCF 685 Query: 667 TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG 726 + C +P+C G + CG M L Sbjct: 686 NNPPFEKMPQGAGCDTC-VHPSCQYSISSNGVCGCL---------QDCGGVMLLDTQSHP 735 Query: 727 KYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL-----RDGAAGVF- 780 K+ N +C + + CE+ DA F+ G G Sbjct: 736 KWRMTCN-KCPSVVGLFEGAIKVKVDST------RSCEQCDAQFIKAEFKPNSGKPGAIE 788 Query: 781 LAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNK 826 ++++ + + ++ D + YL + +Q Sbjct: 789 YESSSYEGC-----IFCDAMKKYPDAINLNHAYLTEESRQRNTQAP 829 >UniRef50_C1DYX0 Predicted protein n=4 Tax=Viridiplantae RepID=C1DYX0_9CHLO Length = 861 Score = 451 bits (1160), Expect = e-125, Method: Composition-based stats. Identities = 174/774 (22%), Positives = 293/774 (37%), Gaps = 86/774 (11%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVG---HIRDLPTSGSAAKKSADSTSTKTAKKPK 60 L + E P+ A +I +L G H + +G+ + Sbjct: 7 VLCVAEKPSLAASIAGFLSEGKHRSRRGGQEVHEFERDFNGARCHFKVTAVIGHVL---- 62 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPG--KEKVVSELKQLAEKADHIYLATDLDREGEA 118 + A +DP ++A + K +VV L++ A+ A H+ L D DREGE Sbjct: 63 SIDFPAKFQSWDLDPAILFDAPVQKKEATPKARVVEHLEREAKGASHLILWLDCDREGEN 122 Query: 119 IAWHLREVIGGDDAR------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 I + + + R F+ ++K +I +A G N A AR+ +D Sbjct: 123 ICFEVIDACAPVMRPNRGDTFVHRAKFSAVSKESIERAMRTLGAPNRAEALAVDARQELD 182 Query: 173 RVVGYMVSPLLWKKIAR--------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 VG + + +S G Q+ + V+R EI + PE+FW + Sbjct: 183 LKVGVAFTRFQTRFFQGRYSHLDASVISYGPCQTPTLNFAVQRHLEIVSHTPEDFWSLHV 242 Query: 225 STTTPS-GEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYS-VLEREDKPTTSKPGA 282 + S G+ L + + R + + + S++ R++ V E+ + Sbjct: 243 EVRSTSLGKTLVTRWERE-----RVFDGDVGEMFRSMVAGDRHALVESVEETEEFKRRPP 297 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-----VNMVRG 337 T L +AAS +G G + M +A+RLY G+I+Y RT+ST + RG Sbjct: 298 GLNTVDLLKAASAGMGMGAHRAMQVAERLYIQGFISYPRTESTAYPPGFDLKGTLKAQRG 357 Query: 338 YISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 + + L + H I P + +A +LY + R Sbjct: 358 HPDWGEWVEELLAGSMTKPRGGKDEGDHPPITPVRSATESAVGG---GEAWRLYDFVARH 414 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 F+A Y S T+ AG R + G+ + GWT VMP + ED L + +G+ Sbjct: 415 FIASVSPDCAYVSRRATLVAGGERFRVSGQTVIAPGWTTVMPH--RAVEDDPLGEIERGE 472 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE---N 514 +L + + Q T PP SEA L+ +E+ GIG ++ + I+ I+ R YV ++ Sbjct: 473 SLPIATVELRQGATSPPPYLSEAELIGLMERNGIGTDASIPTHINNIESRKYVTIQSQGG 532 Query: 515 RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV----LDHFFSD 570 RR +G + EL + +E LD +A +A+ +++ L F + Sbjct: 533 RRVVPTDLGVTLVQGYHRIDPELALPAVRSHVEKQLDMIATGKADHESIVRHTLAQFAAK 592 Query: 571 FTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERC 630 F +D+ E+ + + CGR + + P + C Sbjct: 593 FRNFVDQIERMDTLFEASFDPTCSSGKPFSKCGRCLRYMRLVSTR---------PQRLYC 643 Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCD 690 T + EVL + G T L R C CG + Y + R +C P C Sbjct: 644 PT------QEEVLELPAG----TVKLYNNRECQLCGFELLLYQ-NGDRTYPMC---PWCF 689 Query: 691 GYEIEEGEFR-----IKGYDGP----------IVECEKCGSEMHLKMGRFGKYM 729 + G R + G P + C +CG + LK GR G ++ Sbjct: 690 NHPPFVGGSRPTKGLVSGAPHPRAHPIVDALVVCPCPECGEDDKLK-GREGGWL 742 >UniRef50_B2RGV8 DNA topoisomerase I n=47 Tax=Bacteroidetes RepID=B2RGV8_PORG3 Length = 709 Score = 450 bits (1158), Expect = e-125, Method: Composition-based stats. Identities = 142/657 (21%), Positives = 257/657 (39%), Gaps = 82/657 (12%) Query: 4 ALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 ++I E P+ A+ I + + G Y V ++GH+ K + Sbjct: 2 KVIIAEKPSVAREIARVVRATNKKNGYIEGGGYAVTWALGHLITAAMPEVYGIKGFHKEN 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + + G Y+ P + +++L + A+ I +ATD Sbjct: 62 LPILPPVFTLIPRQVRSGKG----------YKADPSAVAQLKVIEKLFKAAEGIIVATDA 111 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQQARRF 170 REGE + + E +G + R+ + +T AI++ + G + A +AR Sbjct: 112 GREGELVFRFIYEYLGIA-KPFERLWISSLTDKAIKEGLARLQNGAAYDNLYYAARARSE 170 Query: 171 MDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 D +VG + + RG S GRVQ+ + +V R E K F P+ FW++ + Sbjct: 171 ADWLVGINATQAISIAAGRGTYSLGRVQTPTLCMVCSRFLEHKKFEPQPFWQLSLAVKEG 230 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY-SVLEREDKPTTSKPGAPFITST 288 + + R +K + A L++A Y +V K +P + +T Sbjct: 231 DE-------SFRFSSADRWFDKTEATALYDKLKQAPYATVETIVRKEARQEPPLLYDLTT 283 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LQ+ A++R G+ ++T+ +AQRLYE YITY RT S + +D + I+ Sbjct: 284 LQKEANSRFGYSAEQTLSLAQRLYEKAYITYPRTGSRYVPEDVFAEIPAMIAFLHDHPVW 343 Query: 349 PESPNQ------YASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQ 402 + ++ H A+ + + D+ D +Y +I + + Sbjct: 344 GVHARRLTELNAHSVDGKKVTDHHALLITGKKPI-----DVFGDEAVIYDMIAGRMLEAF 398 Query: 403 MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR-------------- 448 D +T+T + + +G I++ +GW ++ RK D+++ Sbjct: 399 SARCVKDISTVTAVCEEVKFILKGEIIKEEGWRSILKNSRKKDKEQAEAEERESRENGEG 458 Query: 449 -ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GI 491 I+P +G L L + AQ TKP +E+SL+ +E GI Sbjct: 459 IIIPQWEEGGQLPLCACSLAQGTTKPKPLHTESSLLAAMETAGKELEDEELRAQFKDCGI 518 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G P+T A+II T+ R Y+ + + + G V + E ++ N + T Q E L Sbjct: 519 GTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVREM--KIGNAEMTGQWEADLA 576 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGI 608 ++ E + + S TQ D+ + + I CP CG+ + Sbjct: 577 KIERGELKERDFRKGIESYATQITDELLSSKILFPKKQ-----SDIHCPKCGKGTLV 628 >UniRef50_C7HY28 DNA topoisomerase III n=1 Tax=Thiomonas intermedia K12 RepID=C7HY28_THIIN Length = 723 Score = 450 bits (1158), Expect = e-125, Method: Composition-based stats. Identities = 149/746 (19%), Positives = 267/746 (35%), Gaps = 90/746 (12%) Query: 5 LVIVESPAKAKTINKYLG-----SDYV--------VKSSVGHIRDLPTSGSAAKKSADST 51 L+I E P+ A+ I +G Y+ V GH+ + + Sbjct: 3 LIIAEKPSVAQAIADVIGGVRRGDGYIDCPQAKTRVTWCFGHLLEQARPEDY----VNGG 58 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATD 111 + P L R G G K + ++ L + A + A D Sbjct: 59 KVLASHLPVIPTAWKLAPRDG---------------GAGKQIKAIRDLLKDATEVVNAGD 103 Query: 112 LDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELN--IDRVNAQQARR 169 DREG+ + + + + +R+ + + ++R+A + + AR+ Sbjct: 104 ADREGQLLVDEVLLFLNW-KGKTTRLWLSSLDDESVRRALVTVKSNDALRPLYESALARQ 162 Query: 170 FMDRVVGYMVSPLLWKKIA-----RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 D ++G S L + + S GRVQ+ + L+V+R+R+I+ F P + ++V A Sbjct: 163 RADWLMGMNASIALSRNLQACGVQGAWSVGRVQTPTLALLVDRQRDIQNFKPRDHYQVQA 222 Query: 225 STTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPF 284 + + Q D ++K + ++ R +V K + P+ Sbjct: 223 TLDGDIRALWQIPEDLQTDDGL-LLDKSAAETCAQAVQGQRATVAAFTRKAGERQAPMPY 281 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFG 344 STLQ+ AS+RLG K T+ AQ LYEA TY R+D L + I Sbjct: 282 ALSTLQKTASSRLGLSAKDTLAAAQELYEAKLATYPRSDCPWLPVEMHAAAAQIIRALGA 341 Query: 345 KKYLPESPNQYASKEN--SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQ 402 + P + N EAH I P+ + + + +A+K+Y L+ ++ Sbjct: 342 AEMAGIDPERRHPAWNTAKVEAHHGIIPTGRGL--AEVSGLSENAKKIYGLLRESYLRLF 399 Query: 403 MTPAKYDSTTLTVGA-GDFRLKARGRILRFDGWTKVMPALRKGDEDRI-----LPAVNKG 456 M P +++ G R KA RI++ GWT++ A ++D LP + +G Sbjct: 400 MPPETFETREALFTFPGAERFKASARIVQESGWTQLGQADNSAEDDETGQVARLPILTEG 459 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYAS 499 L T PP +++ +L+ + E G+G +T AS Sbjct: 460 QQLACESAQVLAKRTSPPKPYTDGTLIAAMTGVHKLVTDPKLKARLKETSGLGTEATRAS 519 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 +I + R Y + + + + G + D L + +L + TA E++L +A+ + Sbjct: 520 MIEVLIAREYAERKKKEIHPTERGVQLIDMLRKVAPDLADPGTTALQEDALAAIASARST 579 Query: 560 WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKM-GIRTASTG---- 614 + + + K G + CP CG RT+ G Sbjct: 580 FDEFMTAQIDAVRESTQKL------LGGQLGATPAILHACPACGGGRCAQRTSKAGATYH 633 Query: 615 VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLI 674 L C + P + + E A A + +C C Sbjct: 634 RCLDCDAAFGDDGGK--------PGKRFEDKHQSEGAAAKAPASGPKCLSCKKPTFKNET 685 Query: 675 DPKRKLHVCGNNPTCDGYEIEEGEFR 700 + + CG C G + + Sbjct: 686 KTGKPYYRCGG---CKGAWWPDRKDE 708 >UniRef50_A3FPU5 DNA topoisomerase n=3 Tax=Cryptosporidium RepID=A3FPU5_CRYPV Length = 835 Score = 450 bits (1158), Expect = e-125, Method: Composition-based stats. Identities = 167/873 (19%), Positives = 320/873 (36%), Gaps = 101/873 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVG---HIRDLPTSGSAAKKSADSTSTKTAKKP 59 K L++ E P+ + TI++ L + + H + G + S + + Sbjct: 5 KVLMVAEKPSISDTISRILSNGKLDTRRGKTPVHEFNGTFMGMNVQFRVTSVAGHVFEI- 63 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 D + N DP ++A K+VS L++ ++ ++ L D DREGE I Sbjct: 64 --DFPQSYSNWEKTDPVSLFDAPIIKNESSSKMVSHLEKESKGCSYLVLWLDCDREGENI 121 Query: 120 AWHLREVIGGDDAR-------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 + + V+ + ++ R F+ I+ I A N + +A R+ +D Sbjct: 122 CFEVINVVSNNMSKGRDQRDWIFRAKFSSISPGDIFFAMKNLTFPNKNESDAVDVRQELD 181 Query: 173 RVVGYMVSPLLWKKIARG---------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD 223 +G S L K + +S G Q+ + V+R I +F+PE+++ + Sbjct: 182 LKIGVAFSRLQTKYLKSKFGDFNKSSIISYGPCQTPTLFFTVQRRDSINSFIPEKYYTIS 241 Query: 224 ASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 A+ + S + + + + F + + V++ K + P Sbjct: 242 ATLSKDSQD---INLIWSRSRVFELQVANCFLQLIQNKKPLSARVVDITSKNSRRIRPLP 298 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGY--- 338 T ++ + +ST LG G +T+ +A++LY +G+ TY RT+++ ++ + + + Sbjct: 299 LNTVSMLKLSSTILGIGPFQTLNIAEKLYLSGFTTYPRTETSRYPKNFDIKSTIAMFKNN 358 Query: 339 -ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 + ++ L + N H I P V + + D++ D+ +LY LI R Sbjct: 359 SVWGSYSSDLLQKGFNLPRKDGLDLGDHPPITP----VRSATQNDLDGDSWRLYDLITRH 414 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 F A K + T+ G + G+ V+ E I+P + Sbjct: 415 FFATISNDIKMINRTIKFDLNGEIFIISGNQVIDHGF-SVIQGRAACHESNIIPDFTLNE 473 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRR 516 + + + TKPP SE+ L+ +EK GIG ++ + I IQ+R YV++ RR Sbjct: 474 VVPIKNIEILSKETKPPPILSESDLLSLMEKHGIGTDASMPTHIQKIQEREYVKLASGRR 533 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS------- 569 K+G + + EL+ ++ME +D +A + KAVL H S Sbjct: 534 LEPTKLGIALVHGIMNIDHELVLPKIRSEMEKYVDLIAKGKYNHKAVLKHSLSVFKLKFL 593 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 F + + E G C C R + + L CS Sbjct: 594 YFAENISLFESLFRLGFTNITASCSRISRCGQCKRYLTYISNILPQRLYCSF-------- 645 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 C+ +++ P+ + + + + +CP + ++ +K C P C Sbjct: 646 CEIYLDI-PQRGTIKIYK-----------ELKCPIDDFELLLFIDQKGKKSIFC---PRC 690 Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVA 749 Y + + C + + +MAC +++C++ + + + Sbjct: 691 --YNDPPFLDAKENMLCKFCPHQTCNFSL-----KSTFFMACPSQDCRDGIITMDSSSTS 743 Query: 750 PPKEDPVPLP---------------ELPCEKSDA---YFVLRDGAAGVFLAANTFPKSRE 791 + D CEK + + F+ P E Sbjct: 744 DWRFDCSRCSISFSIKKNICERLSLGERCEKCGSRKLKICKEKTSQEHFVGC---PNCDE 800 Query: 792 TRAPLVEELYRFRDRLPEKLRYLADAPQQDPEG 824 L+E + LP KL Y +D + G Sbjct: 801 EILSLIEVIS-----LP-KLAYRSDVAKNSFRG 827 >UniRef50_C1LZJ7 Prokaryotic DNA topoisomerase, putative n=1 Tax=Schistosoma mansoni RepID=C1LZJ7_SCHMA Length = 1165 Score = 450 bits (1158), Expect = e-124, Method: Composition-based stats. Identities = 173/864 (20%), Positives = 311/864 (35%), Gaps = 141/864 (16%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 K L + E AK I++ L S I + P + + TS + Sbjct: 27 KILNVAEKNDAAKNISEILSRGGYHRREGISKFNKIYEFPMNLNGQNVMMVMTSV-SGHL 85 Query: 59 PKKDERGALVNRMGVDPWHNWEAHY--EVLPGKEKVVSELKQLAEKADHIYLATDLDREG 116 D + +P ++A +VL E + L++ + + TD DREG Sbjct: 86 TNYDFLPNYKSWHSCNPMVLFDAPIVKQVLKDYEPIKQTLQREVRSCQKLIIWTDCDREG 145 Query: 117 EAIAWHLREVIGGDDARYS--RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E I + +V R F+EIT A+ +A ++ + + A R+ +D Sbjct: 146 ENIGVEVIDVCREIKPNIEILRARFSEITPAAVHRAVDRLTIPDYNASTAVDVRQELDLR 205 Query: 175 VGYMVSPLLWKKIARG---------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G + ++ R +S G Q + VVER RE+ FV E FW + + Sbjct: 206 IGAAFTRFQTLRLRRVFPQALSDQLISYGSCQFPTLGFVVERFREVDQFVSEPFWRIVVT 265 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY-SVLEREDKPTTSKPGAPF 284 S + + Q + F +++ +A L + RY ++E +P T Sbjct: 266 V---SRDEKTTEFQWQRGRLF---DQDCCRAYYEHLNQNRYGQIVEVIKRPKTKWRPTAL 319 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGYISD- 341 T L++ AS +L G K M +A+RLY G+I+Y RT++ D ++V I+D Sbjct: 320 DTVELEKLASRKLQMGAKYAMQLAERLYNKGFISYPRTETKIFPPDLDLKSLVHVQINDS 379 Query: 342 ---NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 +F + L PN + ++S +AH I P V ++ D +LY+L+ R F Sbjct: 380 RWSDFATRILERGPN-PKNGKSSDKAHPPIHPLKVG------DSLQGDEARLYELVTRHF 432 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 +AC T A+ T + + +++G ++ + +V R ++D +P G+ Sbjct: 433 LACLSTDAEGAETIVRLCIDGELFESKGLMILALNYLEVYIYDRWAEKD--MPVFQLGEW 490 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-NRRF 517 + + T PP +EA L+ +++ GIG +T+A I TI+ R YV +E N+ Sbjct: 491 ILPDNIQVLTGQTCPPPLLTEADLISLMDRHGIGTDATHAEHIETIKQRLYVGLEQNKFL 550 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ---- 573 ++G + + + E+ + ++ E L + + VL H + + + Sbjct: 551 VPGQLGMGLVEGYDSMGFEMSKPNLRSEFEADLKLICEGRKTKEEVLHHHLNKYKELFRL 610 Query: 574 QLDKAEKDPEEGGMRPNQMVLTSID---------------------------------CP 600 L++A +R Q + CP Sbjct: 611 ALNQASFLDRALALRLEQEAENVQNISGSVGEMASFAASNNTIDGHNQSNVLNPVVAFCP 670 Query: 601 TCGRKMGIRTAST--------------------------GVFLGCSGYALPPKERCKTTI 634 TC + +R + G FL CSGY C+ I Sbjct: 671 TCHSGLVLRQKRSALRPLTTSSNLSNNSGSNEVNQTSNGGWFLSCSGYP-----NCRYAI 725 Query: 635 NLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDP--------------KRKL 680 + VL + T C +C + S + P +R Sbjct: 726 WFPDSVIHVRVLSETNENT--------CNRCADFIPSSSVRPSNDQLRPLKLGLRFRRNF 777 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKM-----GRFGKYMACT--- 732 ++ D + D + C ++ +K GR + C Sbjct: 778 YLPNGYIQDDDTKESVDNAEAGDSDNILCNCGHSAIQLTVKKPGPNQGRL--FYRCPGLA 835 Query: 733 NEECKNTRKILRNGEVAPPKEDPV 756 C + + + P+ Sbjct: 836 GNSCDFFLWKSQTTPITIAQSSPL 859 >UniRef50_UPI000186EA7F DNA topoisomerase 3-alpha, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186EA7F Length = 901 Score = 450 bits (1157), Expect = e-124, Method: Composition-based stats. Identities = 151/704 (21%), Positives = 264/704 (37%), Gaps = 71/704 (10%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 L + E AK I+ +L S I + TS + Sbjct: 2 TILNVAEKNDAAKNISFFLSKGSARKRESLSVYNKIYEFEFKLFNQNCKMVMTSV-SGHL 60 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEVLPGKE--KVVSELKQLAEKADHIYLATDLDREG 116 N DP + KE K + LK + D + + TD DREG Sbjct: 61 LNYCFPPTHKNWSTTDPSSLFTVPVNKFCAKENFKTQNNLKNEVKYCDTLIIWTDCDREG 120 Query: 117 EAIAWHLREVIGGDDARYS--RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E I + + +V R F+EIT ++ +A N N +A R +D Sbjct: 121 ENIGFEIIDVCKKVKPNIKIYRAKFSEITSASVMRAINNLEMPNKSLSDAVDVRMELDLR 180 Query: 175 VGYMVSPLLWKKIAR---------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G + + + +S G Q + VVER + I F+ E FW ++ Sbjct: 181 IGAAFTRFQSLYLQKKFPDNFKSTVVSYGSCQFPTLGFVVERFKNISQFISEPFWRIEVK 240 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 S + L + + ++ F E +E V++ + KP + P Sbjct: 241 --DNSNKNLIVDFNWERNRMFDKSCCEV--LYDKCIESNLAKVIKVDSKPKSKYRPKPLD 296 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVNMVRGYISDN- 342 T L++ AS +L K + A++LY GYI+Y RT++ + D +V+ +D+ Sbjct: 297 TVELEKLASKKLKINAKLALKTAEKLYTQGYISYPRTETNIFPKELDLRPLVQRQTTDSN 356 Query: 343 ---FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFV 399 F K L + PN S +AH I P ++ + +Y+LI R F+ Sbjct: 357 WGEFALKVLVDGPN-PNQGTKSDQAHPPIHPIKYA------SNLTGVEKNIYELIVRHFL 409 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 AC A+ T + + + A+G ++ + V P ++ L N GD Sbjct: 410 ACLSKNAEGIETAVEIDLANEIFTAKGLMITARNYLDVYPYDVWNAKEINL--YNVGDVF 467 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN-RRFY 518 ++ + T PP +EA L+ +EK GIG +T+A I TI+ R YV ++N + F Sbjct: 468 KPA-VSLVEGKTNPPELLTEADLIALMEKHGIGTDATHADHIETIKARFYVGLKNDKYFV 526 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 +G + + E+ + A++E L + +E + VL+ + + + Sbjct: 527 PRTLGMGLVEGYNNVGFEMAKPNLRAELEADLSSITRNEKMPQDVLNKHINKYKNIFEVV 586 Query: 579 EKDPE---------------EGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYA 623 + + + + N + + ++C CG M + + CS Sbjct: 587 KTNSKNLFEIINSYIQGNNPISSEKENNVPKSPMNCRECGNPMIKEIKNNKISFSCSN-- 644 Query: 624 LPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGT 667 K +C IN+ + + + CPKCG+ Sbjct: 645 ---KSQCLNVINISNTVKDVEITND------------SCPKCGS 673 >UniRef50_B8G1K2 DNA topoisomerase n=2 Tax=Desulfitobacterium hafniense RepID=B8G1K2_DESHD Length = 777 Score = 450 bits (1157), Expect = e-124, Method: Composition-based stats. Identities = 160/788 (20%), Positives = 287/788 (36%), Gaps = 105/788 (13%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 MGK L+I E P++A+ K LG +Y++ +GH+ +L + Sbjct: 1 MGKTLIIAEKPSQAREYAKTLGVKGKREGYFENDEYIISWCIGHLFELKAPENY------ 54 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAE--KADHIY 107 PK +R + R+ V P E Y + G K L+ L + + Sbjct: 55 ------MDLPKVGKR-WSIRRLPVLPRLG-EFQYGLKSGTAKQFKVLQGLLRSPEVQQVI 106 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI--DRVNAQ 165 TD DREG+ + + + +G R+ + +T+ AIR+ +K + A Sbjct: 107 CGTDADREGQLLFQEVWDAVG-SKKPLFRLWISSLTQEAIREGMSKLRPVGEVEGLAQAG 165 Query: 166 QARRFMDRVVGYMVSPLLW---------KKIARGLSAGRVQSVAVRLVVEREREIKAFVP 216 R + D G ++ +K +S GRVQ+ + LVVE+E I+ FVP Sbjct: 166 YGRSYGDWDFGMNLTEGFTALFGSFDPVRKKPNVISIGRVQTPTLALVVEQEWAIENFVP 225 Query: 217 EEFWEVDASTTTPSGEALALQVT----------HQNDKPFRPVNKEQTQAAVSLLEKARY 266 + EV+A + G + D ++ ++ + V+ ++ Sbjct: 226 VAYVEVEAEFASGQGSYKGKWFDPAVKNTRDKNQETDNAQMMLDLDRGKEIVAKVQGKPG 285 Query: 267 SVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTN 326 + +DK T F ++L +AS R GFG +K + +AQ LYE ITY RTD Sbjct: 286 RIRSVKDKETKEPHPLLFDLTSLTVSASKRYGFGAEKVLKIAQSLYEKKAITYPRTDCNY 345 Query: 327 LSQDAVNMVRGYIS-------DNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAES 379 L D + ++ ++ ++ K+ L N AH AI P+ + Sbjct: 346 LPPDMLPKLKVHLQALEQSPFASWVKEALDNPLPGGKRVINEITAHHAIIPT----TEKM 401 Query: 380 LKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP 439 + ++ D +K++++I +F+ PA+Y + + +G+ L GW K+ Sbjct: 402 IPNLSPDERKIWEMIVLRFLCIWFPPARYAEKEVVTVVEEEFFLTKGKTLLESGWKKIEN 461 Query: 440 ALRKGD-EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------- 487 + + LP + + + + Q TKPP R+++ L+K +E Sbjct: 462 TEKYTEGSGLQLPLLQQNEEVVTRSCQALQKETKPPKRYTQGDLIKAMEGAGKEIEDETL 521 Query: 488 -----KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE---LMN 539 +G+G +T +II + DRGY+ + + G + ++E L++ Sbjct: 522 RRQLKGKGLGTVATRGAIIENLLDRGYLLQQQKVLVPTAKGTELIRLIKERLPRAQLLIS 581 Query: 540 YDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDC 599 + T QME L QV E ++ +++ G +P Sbjct: 582 AEMTGQMEYELAQVERGELPLSRYMEKVEEAIRGIIEELRHYEATRGKKPLAF------A 635 Query: 600 PTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAK 659 P G ++ S E + + + E + A Sbjct: 636 PQKAGASGRKSKSN-------------LEEKPQELPVQAKVTKAAKTRQESPASAAEENL 682 Query: 660 RRCPKCGTAMDSYLIDPKRKLHVCGNNPT-CDGYEIEEGEFRIKGYDGPIVECEKCGSEM 718 CP CG + + C N C + + K G Sbjct: 683 GICPSCGGGVVEREKG-----YGCQNWKNGCPFILWKNPICGKVLTPAQVKSLLKKGKTN 737 Query: 719 HLKMGRFG 726 +K R Sbjct: 738 LIKGFRSK 745 >UniRef50_Q1QVL1 DNA topoisomerase n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QVL1_CHRSD Length = 654 Score = 449 bits (1155), Expect = e-124, Method: Composition-based stats. Identities = 146/656 (22%), Positives = 246/656 (37%), Gaps = 79/656 (12%) Query: 5 LVIVESPAKAKTINKYLG------SDYVV------KSSVGHIRDLPTSGSAAKKSADSTS 52 L+I E P+ A+ I L Y+V VGH+ + + + Sbjct: 3 LIIAEKPSLARAIADALPTAPQRHEGYLVCGETCISWCVGHLLEQAPPDAYDARYQQWRL 62 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 P+ + ++ +++L ++AD + A D Sbjct: 63 DHLPIVPR-------------------QWKLIPRSKARAQLAVIRKLLKRADTVVHAGDP 103 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRF 170 DREG+ + + +G + SR++ +++ + A+RQA + A +AR Sbjct: 104 DREGQLLVQQVIAHLGWRGS-ISRLLVSDLNRPAVRQALQCIEDNARYQSLFEAAEARSR 162 Query: 171 MDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 D V G +S + LS GRVQ+ + L+V R+ +I+AF P F+ + A Sbjct: 163 ADWVYGINLSRAWTLTGRQAGYQGVLSVGRVQTPVLGLIVRRDLDIEAFTPRPFYPLWAD 222 Query: 226 TTTPSGEALALQ---VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 G A H D+ R + + +A + L A + E + K T Sbjct: 223 LKVEHGTLRAWWQPQAPHPLDEQGRLLERAPAEALAAHLPGAEGHLSELQSKRQTQSAPL 282 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISD 341 P+ S LQ A+ R K+ + + Q LYE ITY R+D L + + + Sbjct: 283 PYSLSALQVDAARRYKLPAKRVLDICQTLYERHQLITYPRSDCRYLPEGHFAAAKKTLDT 342 Query: 342 NFGKKYLPE--------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 + S A + AH A+ P+ A + D +++L Sbjct: 343 ACAQDATLRGWYQGADFSRRSRAWNDKQVGAHHALAPTGRTFDA---SRLTGDEANVFRL 399 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAV 453 I R +A +P +A+GR + GW P DE LPA+ Sbjct: 400 IARNVLAQFYSPLVTRDVKAAFSIHGEHFRAQGREILEPGWK---PLFTTRDEAPPLPAL 456 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPST 496 ++G+A +V+ T+PP F++ASL+K + + G+G +T Sbjct: 457 HEGEAARVVDCAVEDRQTRPPDPFTDASLIKAMMNIARYVDDATVKRTLRDTDGLGTEAT 516 Query: 497 YASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 A I+ T+ RGY+ + A + G + L + + TA E L +A Sbjct: 517 RAGIMETLVTRGYIVRQQGALRATRTGRALIQALPDTA---TRPERTALWEQRLADIAEG 573 Query: 557 EAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAS 612 + A LD D Q LD+A+ + S P+ G+K G R S Sbjct: 574 RGDADAFLDALVGDVRQLLDQADAARMRQALATTGGAEPS--SPSRGKKRGTRRGS 627 >UniRef50_A5FFH7 DNA topoisomerase n=1 Tax=Flavobacterium johnsoniae UW101 RepID=A5FFH7_FLAJ1 Length = 689 Score = 449 bits (1155), Expect = e-124, Method: Composition-based stats. Identities = 160/641 (24%), Positives = 262/641 (40%), Gaps = 72/641 (11%) Query: 4 ALVIVESPAKAKTIN----------KYL-GSDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 +VI E P+ A+ I YL G+ Y V ++GH+ L K + +S Sbjct: 2 KVVIAEKPSAAREIAVLLGANEKKDGYLAGNGYFVTWALGHLVGLGLPEDYGIKGFEKSS 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 P V + +D A Y G +K + +K + +D I +ATD Sbjct: 62 LPILPDPFL----LTVRKQKID------AGYTADAGAQKQLKTIKYVVGLSDLIIVATDA 111 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRF 170 REGE I ++ E + R+ + +T+ AIR+ P A QAR Sbjct: 112 GREGELIFRYIYEYLEFRKPFV-RLWISNLTEKAIRKGLENLKPASELDGLYLAAQARSR 170 Query: 171 MDRVVGYMVSPLLWKKIARGL-SAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 D +VG S L G+ S GRVQ+ + LV R E K+F E +W++ + + Sbjct: 171 ADWLVGINASQALSLAQGDGVFSLGRVQTPTLALVCSRYLENKSFNIEPYWQLQLTHSRN 230 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYS--VLEREDKPTTSKPGAPFITS 287 + T ++K R NK Q A+ +E+ + V E K +T +P F + Sbjct: 231 -----FMLFTSISEK--RWDNKRQAMDALRAIERNAATAWVSSVEIKNSTEQPPLLFDLT 283 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 LQ+ AST L +T+ +AQ LYE +I+Y RT S ++S D + + I ++ Sbjct: 284 GLQKQASTDLSLSAGETLSIAQSLYEKQFISYPRTGSRSISADVWDEIPSLIKALGTREN 343 Query: 348 LPESP--------NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFV 399 E+ N+ E H + P++ A + +Y LI + + Sbjct: 344 FREAISTLKLGRLNKRIVSEAGVTDHHGLLPTERIPSA-----LSGKETAIYNLIAGRLL 398 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKV-MPALRKGDEDRILPAVNKGDA 458 P + T + + F G + GW V L G+ + LP + +GD Sbjct: 399 EAVSEPCIKEITKVNLQVLHFDFILSGSRIIESGWRGVKARFLESGEPGQELPEIKRGDE 458 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRPSTYASIIS 502 L + E + T PPA ++EA L+ +E GIG P+T A+II Sbjct: 459 LKIKESAVLEKATSPPALYTEAGLLSVMENAGKKSQDLQERKILQAIGIGTPATRAAIIE 518 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 T+ DR Y++ + + + G +V + +++ + + + TAQ E L ++ N EA+ Sbjct: 519 TLFDRKYIQRQGKSLIPTEKGLMVYELVKD--KRIADVAMTAQWETELWKIENKEADAAT 576 Query: 563 VLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCG 603 S T + + P M P + CP C Sbjct: 577 FQKQMESYATSITKELLETPRPHDMVP------DLCCPRCN 611 >UniRef50_B1HX02 DNA topoisomerase III n=93 Tax=Bacillaceae RepID=B1HX02_LYSSC Length = 725 Score = 449 bits (1154), Expect = e-124, Method: Composition-based stats. Identities = 153/747 (20%), Positives = 290/747 (38%), Gaps = 102/747 (13%) Query: 4 ALVIVESPAKAKTIN-----------------KYLGSDYVVKSSVGHIRDLPTSGSAAKK 46 +VI P +A + Y + ++ + GH+ +L T Sbjct: 2 KIVIAAKPDQAAKLAAPWSFTIKTGYFEVKANSYFPNGAIITWATGHLCELKT------- 54 Query: 47 SADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD-- 104 P++ + ++ P Y+V K K + +K L ++AD Sbjct: 55 ------------PEEYDSTWKKWKLETLPIIPDRFEYKVSKSKYKQFTIIKNLVKRADIQ 102 Query: 105 HIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRV 162 I + D REGE I + V G + R+ + +T+N+++ F+ P D Sbjct: 103 EIIIGGDAGREGELIIRTILRVCGV-NKPMKRLWISSLTENSVKNGFSNLLPEAQTKDIY 161 Query: 163 NAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPE 217 +R D ++G S L + + S GRVQ+ + L+V RE EI F E Sbjct: 162 YEALSRSCADWLIGINTSRLYTVLLKKNGVKDVFSIGRVQTPTLALIVHREHEIANFKSE 221 Query: 218 EFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTT 277 FWEV+A L+ + R + ++Q A + + + + Sbjct: 222 PFWEVEAVFHFAGK---MLKAKWHKNNMSRVLEEKQAIAIANFCLHKNVDITKIIKETKE 278 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 P F S LQ A+ F +KT+ + Q+LY G ++Y R+DS L+ + + Sbjct: 279 YAPPLLFNLSGLQATANKAYKFSPQKTLDILQKLYVKGLVSYPRSDSQFLTSEEAKTLPT 338 Query: 338 YISD----NFGKKYLPESP-----NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ 388 +++ + K LP N+ E H AI ++ +L + + + Sbjct: 339 ILNNLSKMDKYKNLLPPPINSIMHNKRYVNEKKVTDHHAIIVTE---QMPNLSKLSMEEE 395 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF-RLKARGRILRFDGWTKVMPALRKG--- 444 K+Y L+ RQ +A A + TT+ ++G+ +GW KV+ + Sbjct: 396 KIYDLVARQVIAAHYNHAIFAYTTIHSLVDKRAEFISKGKEQIEEGWRKVIYPTKDSSSQ 455 Query: 445 DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR--------------- 489 +E+ +LP +++ + T+ + + Q T+PP R+SE L+ ++ Sbjct: 456 EEEEMLPLLHENELGTVAQASVKQGATQPPNRYSEGHLITLMKTAGKHLDDAELEKVLSK 515 Query: 490 --GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQME 547 G+G +T A II T++DR Y+ ++ + +A G ++ + L EN L + TA+ E Sbjct: 516 TEGLGTEATRAGIIGTLKDRQYIEIKKNQVFATSKGMLLIEALGEN-SLLTSPSMTAKWE 574 Query: 548 NSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMG 607 L ++ A +A ++ + + A + + ++ S + P + Sbjct: 575 QRLAEIGEGHASPQAFMEQVKKLTYKLITDAHEREKAWTFDQKEVEKISANNPYQKKYKK 634 Query: 608 IRT------------ASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED----A 651 +T G F GCS Y CK +++ ++ ++ Sbjct: 635 EKTVVGKCILCNGSIIDHGTFYGCSNYKA---ANCKFSVSKKILSKTISQTNVRKLLATG 691 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKR 678 ET+ ++ ++ K A + R Sbjct: 692 ETDMIKGFKKGQKTFNAHLIWDKQEHR 718 >UniRef50_A7I6L6 DNA topoisomerase n=5 Tax=Methanomicrobiales RepID=A7I6L6_METB6 Length = 942 Score = 449 bits (1154), Expect = e-124, Method: Composition-based stats. Identities = 164/709 (23%), Positives = 281/709 (39%), Gaps = 55/709 (7%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L++ E A I + L V D S + + + + Sbjct: 3 LIVAEKNISAHRIAQILAGGTRVIEKK----DAGVSTYSFGDTITVGLRGHVVEVDFEPG 58 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 P +A +P ++++VS +++LA AD + +ATD D EGE I Sbjct: 59 YENWRSEKYTPRSLIDAKTIKVPTEKRIVSLVQKLARHADRVTIATDFDTEGELIGKEAY 118 Query: 125 EVIGGDDARYS--RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 E++ + R F+ IT I AF +L+ A +AR+ +D + G ++ Sbjct: 119 ELVRAVNKNVKIDRARFSAITAQEIGSAFANTTDLDFALAAAGEARQSIDLMWGASLTRF 178 Query: 183 LWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 + RG LS GRVQS + ++V+RE+EI+ FVPE++W++ T + ++ Sbjct: 179 ISLAAKRGGNNILSVGRVQSPTLSMIVDREKEIEKFVPEKYWQLGLLTEKAGEQ---IEA 235 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 H N + ++ K V E + + +PF T+T AA+ RLG Sbjct: 236 RHTNGR----FKDQKAAELARDRTKEPLVVTEVREGTKQDRSPSPFDTTTYIVAAA-RLG 290 Query: 299 FGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-----VNMVRGYISDNFGKKYLPESPN 353 F M +A+ LY GYI+Y RTD+T + +R + Sbjct: 291 FSAANAMRIAEELYMNGYISYPRTDNTVYPASLDLNGVLATIRNSPFTKDVDWIISHRRA 350 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 + + S H I P+ V + + DA ++Y+L+ R+F+A A + + + Sbjct: 351 EPTRGKKSSTDHPPIYPTGVATR----EGIGDDAFRIYELVLRRFLATLAPDALWKTLKV 406 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKP 473 AG G +L GW V P + ILPA G+ L + ++ + T P Sbjct: 407 NFEAGGETYTVTGGLLLEPGWHAVYPFSEAK--ETILPAFVTGEKLPIRKVNLEEKETLP 464 Query: 474 PARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEEN 533 PAR++++ L++ +E+ G+G ST +I+ + R Y+ E +G +VT+ LE+N Sbjct: 465 PARYTQSKLIQRMEELGLGTKSTRHEVIARLVSRKYI--EGNPLRPTLVGRVVTEALEQN 522 Query: 534 FRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMV 593 + + T +E+ + Q+ + V+ S + D+ E + + G Sbjct: 523 ADTITKPEMTQTIESHMQQIKESKRTRDDVIAESRSMLHKAFDQLEANEQVIGNDIRDRT 582 Query: 594 LTSID---CPTCGRKMGIRTAS-TGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE 649 ++ CP CG + I+ + F+GCS Y C I L Sbjct: 583 AEELNLGRCPACGGTLAIKHMRGSTQFIGCSRYP-----ECTFNIGLPVTQWGW------ 631 Query: 650 DAETNALRAKRRCPKCGTAMDSYLIDPKRKL-HVCGNNPTCDGYEIEEG 697 A+R C K + R C P C Sbjct: 632 -----AVRTDDICDKHHLHFVRLVRKGARPWDIGC---PLCHHISSNAE 672 >UniRef50_O49571 DNA topoisomerase like-protein n=1 Tax=Arabidopsis thaliana RepID=O49571_ARATH Length = 1179 Score = 448 bits (1153), Expect = e-124, Method: Composition-based stats. Identities = 212/723 (29%), Positives = 328/723 (45%), Gaps = 87/723 (12%) Query: 83 YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDA-----RYSRV 137 YEVLP + + LA +A+++ LA+D DREGEAIAWH+ E++ A +RV Sbjct: 496 YEVLPSYGHI----RDLATRAENLILASDPDREGEAIAWHIIEMLQQQGALHESMTVARV 551 Query: 138 VFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQ 197 VF+EIT++AI+ A P E++ D V+A ARR +D ++G+ +SPLLW+K+ SAGRVQ Sbjct: 552 VFHEITESAIKSALQSPREIDGDLVHAYLARRALDYLIGFNISPLLWRKLPGCPSAGRVQ 611 Query: 198 SVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA-LALQVTHQNDKPFRPVN---KEQ 253 S A+ LV +RE EI F P+E+W V A + +T N K ++ + Sbjct: 612 SAALALVCDRESEIDGFKPQEYWTVGIKVKGKDNSATFSAHLTSLNSKRLNQLSISSEAN 671 Query: 254 TQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE 313 Q ++ + V + T P P+ITSTLQQ A+ +L F TM +A Sbjct: 672 AQDIEQRIKSEGFLVKGTKTSTTRKNPPTPYITSTLQQDAANKLHFSTAHTMKIADE--- 728 Query: 314 AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSD 372 A+ ++ +++ +GK + +SP +Y K +N+QEAHEAIRP+D Sbjct: 729 -----------------AIKDIQSLVAERYGKNFTSDSPRKYFKKVKNAQEAHEAIRPTD 771 Query: 373 VNVMAESLKDM-EADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFR--LKARGRIL 429 + + ++ + +AD+ KLY LIW + VACQM PA L +G ++ + Sbjct: 772 IRRLPSTIASLLDADSLKLYTLIWSRAVACQMEPASIAQIQLDIGNASESIIFRSSCSKV 831 Query: 430 RFDGWTKVMP-----ALRKGDED---------RILPAVNKGDALTLVELTPAQHFTKPPA 475 F G+ V A++ D D + L ++ GD L + E+ QH T+ P Sbjct: 832 EFLGYQAVYEDPEAKAIKNNDNDQSSEREETFKTLSSLKDGDLLQIGEVELKQHHTQHPP 891 Query: 476 RFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFR 535 R+SE SLVK+LE+ GIGRPSTYASI +Q R YV ++NR Y E +V+ L F Sbjct: 892 RYSEGSLVKKLEELGIGRPSTYASIFRVLQHRKYVTIKNRVLYPEFRARMVSAFLTHYFT 951 Query: 536 ELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLT 595 E+ +Y FTA ME LD V+ EWK +L +++ F+ + E Sbjct: 952 EITDYSFTADMETELDNVSGGVTEWKGLLRDYWTRFSAYCKRVENVQRSQLY-------- 1003 Query: 596 SIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNA 655 GR + ++ F+ + Y E N V E ++L + + Sbjct: 1004 -------GRHLKFQS----KFIAKTLYGEDEDEDDPPKNNCVEEPKLLGLHPNT-----S 1047 Query: 656 LRAKRRCPKCGTAMDSYLIDPKRKLHVCG-NNPTCDGYEIEEGEFRIKGYDGPIVECEKC 714 + +C G + + E + Y + + Sbjct: 1048 EKVILKCGPYGHYVQLGEDKKGHTPKRANAAHIKDVNSITLESALELLRYPLTLGTHPED 1107 Query: 715 GSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRD 774 G + LK+ + G T K RN P +P + K + +R Sbjct: 1108 GQPVVLKLSKSG-----------FTIKHRRNMATVPKNTEPGEVTLERAMKLLSGKNVRK 1156 Query: 775 GAA 777 Sbjct: 1157 SGR 1159 >UniRef50_UPI0000DB782E PREDICTED: similar to topoisomerase (DNA) III alpha n=3 Tax=Neoptera RepID=UPI0000DB782E Length = 958 Score = 448 bits (1152), Expect = e-124, Method: Composition-based stats. Identities = 143/706 (20%), Positives = 268/706 (37%), Gaps = 68/706 (9%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 L + E AK I YL I + S K ++ + Sbjct: 2 NVLNVAEKNDAAKNIAAYLSRGTYKRREGLWLYNKIFEF-NSYLWNKNCHMIMTSVSGHL 60 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEVLPGKE---KVVSELKQLAEKADHIYLATDLDRE 115 + G P ++A +E K+ L++ +K + + + TD DRE Sbjct: 61 LNCEFVGIYRKWQSCHPLSLFDAPVVKQCSQESSIKIKKTLEKEVQKCNALIIWTDCDRE 120 Query: 116 GEAIAWHLREVIG--GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 GE I + + +V + R R F+EIT+ ++ ++ E + +A R +D Sbjct: 121 GENIGFEIIQVCRAIKPNIRIYRAKFSEITQTSVNRSLQNLCEPDKAISDAVDVRSELDL 180 Query: 174 VVGYMVSPLLWKKIARG---------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 +G + ++ + +S G Q + VVER I+ F E +W++ Sbjct: 181 RIGAAFTRFQTLRLRKVFPTTLADMLISYGSCQFPTLGFVVERFLAIEEFKIEPYWKIKV 240 Query: 225 STTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPF 284 + ++++ + K F + E LE+ +V + KPT+ P Sbjct: 241 ---MDIRDNISVEFKWERGKLFEKLPCEIFLDIC--LEQPNATVQKISSKPTSKWRPLPL 295 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVNMVRGYISD- 341 T L++ S +L K+ M +A++LY G I+Y RT++ + + +++V I++ Sbjct: 296 DTIELEKQGSRKLNLNAKEIMRIAEKLYTQGLISYPRTETNIFPKELNLISLVNQQINNP 355 Query: 342 ---NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 NF ++ L + N K++ Q AH I P ++ + K+Y+ + R F Sbjct: 356 AWGNFAQQLLEKGVNPRKGKKSDQ-AHPPIHPIKY------CDNLNGNEAKVYEFVVRHF 408 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 +AC + A + + + A G + + V + ++ + +G Sbjct: 409 LACLSSNAIGHQVIVEIDIAGEKFNANGLQVIEKNYLDVYIYEKWN--EQKIHNYREGQV 466 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR-VENRRF 517 + + T PP +EA L+ ++K GIG +T+A I TI+ R YV V+ + Sbjct: 467 FKPTSIEMIEEKTSPPQLLTEADLITLMDKHGIGTDATHAEHIDTIKSRQYVGLVDEKYL 526 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT----- 572 K+G + + ++ A++E L + K VL++ + + Sbjct: 527 IPGKLGIGLVLGYDNMGFQMSKPGLRAELERDLKLICEQRKNAKEVLENQINKYRDLFKI 586 Query: 573 -------------QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGI--RTASTGVFL 617 D+ +E + CP CG M + R G ++ Sbjct: 587 SMERANLIDNALADYFDEQPTKIQELENNFPSQDIAIFKCPKCGLDMTLKDRKQGMGKYI 646 Query: 618 GCSGYALPPKERCKTTIN---LVPENEVLNVLEGEDAETNALRAKR 660 GC GY C I + + E+ + + G D N L R Sbjct: 647 GCIGYPT-----CNNVIWFPQYIEDVEITDNICGCDPTFNELLNIR 687 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_Q9KRB2 DNA topoisomerase 1 n=401 Tax=cellular organisms... 899 0.0 UniRef50_Q8K9P7 DNA topoisomerase 1 n=2 Tax=Gammaproteobacteria ... 759 0.0 UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_... 730 0.0 UniRef50_C1SMY2 DNA topoisomerase n=1 Tax=Denitrovibrio acetiphi... 724 0.0 UniRef50_A7NJW2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A7NJW... 719 0.0 UniRef50_B5EJ79 DNA topoisomerase n=61 Tax=Proteobacteria RepID=... 706 0.0 UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5... 706 0.0 UniRef50_B9L0B0 DNA topoisomerase n=1 Tax=Thermomicrobium roseum... 706 0.0 UniRef50_D1U7W1 DNA topoisomerase n=1 Tax=Desulfovibrio aespoeen... 702 0.0 UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8... 700 0.0 UniRef50_C6BUQ9 DNA topoisomerase n=14 Tax=Desulfovibrionales Re... 699 0.0 UniRef50_B0MRI8 DNA topoisomerase n=1 Tax=Eubacterium siraeum DS... 698 0.0 UniRef50_D1C7I9 DNA topoisomerase n=8 Tax=Bacteria RepID=D1C7I9_... 698 0.0 UniRef50_C9LSJ2 DNA topoisomerase n=3 Tax=Veillonellaceae RepID=... 698 0.0 UniRef50_C6HWV0 DNA topoisomerase n=1 Tax=Leptospirillum ferrodi... 695 0.0 UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia st... 694 0.0 UniRef50_A3EPL6 DNA topoisomerase n=2 Tax=Leptospirillum sp. Gro... 692 0.0 UniRef50_C1F6V0 DNA topoisomerase n=1 Tax=Acidobacterium capsula... 692 0.0 UniRef50_A8ZW15 DNA topoisomerase n=3 Tax=Desulfobacteraceae Rep... 690 0.0 UniRef50_Q67PC7 DNA topoisomerase n=3 Tax=Bacteria RepID=Q67PC7_... 689 0.0 UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_... 687 0.0 UniRef50_D0LR99 DNA topoisomerase n=169 Tax=cellular organisms R... 687 0.0 UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM ... 684 0.0 UniRef50_D1BMP2 DNA topoisomerase n=6 Tax=Firmicutes RepID=D1BMP... 680 0.0 UniRef50_Q9KA23 DNA topoisomerase 1 n=107 Tax=Bacteria RepID=TOP... 676 0.0 UniRef50_Q2LT40 DNA topoisomerase n=2 Tax=Bacteria RepID=Q2LT40_... 674 0.0 UniRef50_A0LDV2 DNA topoisomerase I n=7 Tax=Proteobacteria RepID... 672 0.0 UniRef50_Q7NGH1 DNA topoisomerase n=1 Tax=Gloeobacter violaceus ... 672 0.0 UniRef50_C1ABE5 DNA topoisomerase n=1 Tax=Gemmatimonas aurantiac... 672 0.0 UniRef50_B9L7D9 DNA topoisomerase n=1 Tax=Nautilia profundicola ... 669 0.0 UniRef50_C0QYG0 DNA topoisomerase n=2 Tax=Brachyspira RepID=C0QY... 669 0.0 UniRef50_A9FRC6 DNA topoisomerase I n=1 Tax=Sorangium cellulosum... 667 0.0 UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus R... 667 0.0 UniRef50_B1GYR4 DNA topoisomerase n=1 Tax=uncultured Termite gro... 665 0.0 UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophi... 664 0.0 UniRef50_D1B6D6 DNA topoisomerase I n=3 Tax=Synergistaceae RepID... 663 0.0 UniRef50_B5YKX8 DNA topoisomerase n=1 Tax=Thermodesulfovibrio ye... 663 0.0 UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=T... 662 0.0 UniRef50_A6DDI1 DNA topoisomerase n=1 Tax=Caminibacter mediatlan... 662 0.0 UniRef50_Q2FZ32 DNA topoisomerase 1 n=260 Tax=Bacteria RepID=TOP... 660 0.0 UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM ... 659 0.0 UniRef50_C6WSV7 DNA topoisomerase n=4 Tax=Proteobacteria RepID=C... 657 0.0 UniRef50_Q01N68 DNA topoisomerase n=7 Tax=Bacteria RepID=Q01N68_... 655 0.0 UniRef50_B3EPW7 DNA topoisomerase n=12 Tax=Chlorobiaceae RepID=B... 654 0.0 UniRef50_C6P2V7 DNA topoisomerase n=2 Tax=Proteobacteria RepID=C... 653 0.0 UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria Re... 652 0.0 UniRef50_D0KVS8 DNA topoisomerase n=6 Tax=Gammaproteobacteria Re... 651 0.0 UniRef50_C0W9S2 DNA topoisomerase n=1 Tax=Acidaminococcus sp. D2... 650 0.0 UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria ... 650 0.0 UniRef50_B8E2F6 DNA topoisomerase n=1 Tax=Dictyoglomus turgidum ... 648 0.0 UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q... 647 0.0 UniRef50_Q47L55 DNA topoisomerase n=4 Tax=Actinomycetales RepID=... 645 0.0 UniRef50_B1M0P4 DNA topoisomerase n=14 Tax=Alphaproteobacteria R... 641 0.0 UniRef50_B2KBN6 DNA topoisomerase n=1 Tax=Elusimicrobium minutum... 640 0.0 UniRef50_C1D174 DNA topoisomerase n=34 Tax=cellular organisms Re... 639 0.0 UniRef50_B1VM20 DNA topoisomerase n=6 Tax=Streptomyces RepID=B1V... 638 0.0 UniRef50_Q9X909 DNA topoisomerase 1 n=14 Tax=cellular organisms ... 638 0.0 UniRef50_B0VJB5 DNA topoisomerase n=1 Tax=Candidatus Cloacamonas... 637 0.0 UniRef50_D1Y390 DNA topoisomerase n=1 Tax=Pyramidobacter piscole... 636 0.0 UniRef50_D1B572 DNA topoisomerase n=7 Tax=Campylobacterales RepI... 635 e-180 UniRef50_A8RBU5 DNA topoisomerase n=9 Tax=Bacteria RepID=A8RBU5_... 630 e-179 UniRef50_P34185 DNA topoisomerase 1 n=39 Tax=Bacteria RepID=TOP1... 629 e-178 UniRef50_Q256J1 DNA topoisomerase I-fused to SWI domain n=18 Tax... 628 e-178 UniRef50_Q1RIM1 DNA topoisomerase 1 n=35 Tax=Rickettsiales RepID... 627 e-178 UniRef50_A8SJ74 DNA topoisomerase n=1 Tax=Parvimonas micra ATCC ... 626 e-177 UniRef50_Q28MI5 DNA topoisomerase n=13 Tax=Rhodobacterales RepID... 625 e-177 UniRef50_P73810 DNA topoisomerase 1 n=13 Tax=cellular organisms ... 624 e-177 UniRef50_O83409 DNA topoisomerase 1 n=4 Tax=Treponema RepID=TOP1... 623 e-177 UniRef50_Q2J4Z1 DNA topoisomerase n=10 Tax=Bacteria RepID=Q2J4Z1... 620 e-176 UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria... 620 e-176 UniRef50_D0LEI6 DNA topoisomerase n=36 Tax=Actinomycetales RepID... 618 e-175 UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms R... 617 e-175 UniRef50_D0D7V2 DNA topoisomerase n=1 Tax=Citreicella sp. SE45 R... 616 e-174 UniRef50_O69548 DNA topoisomerase 1 n=28 Tax=Actinomycetales Rep... 615 e-174 UniRef50_C7MGF4 DNA topoisomerase n=5 Tax=Actinobacteridae RepID... 615 e-174 UniRef50_C4FH65 DNA topoisomerase n=1 Tax=Bifidobacterium angula... 610 e-173 UniRef50_B8DVL2 DNA topoisomerase n=14 Tax=Actinobacteridae RepI... 608 e-172 UniRef50_A5CF60 DNA topoisomerase n=2 Tax=Orientia tsutsugamushi... 608 e-172 UniRef50_Q1UZD4 DNA topoisomerase n=4 Tax=Bacteria RepID=Q1UZD4_... 608 e-172 UniRef50_Q9ZMV7 DNA topoisomerase 1 n=47 Tax=Epsilonproteobacter... 607 e-172 UniRef50_Q83FM2 DNA topoisomerase n=2 Tax=Tropheryma whipplei Re... 604 e-171 UniRef50_B3DUA2 DNA topoisomerase n=13 Tax=Actinobacteridae RepI... 604 e-171 UniRef50_C6V581 DNA topoisomerase n=2 Tax=Neorickettsia RepID=C6... 600 e-169 UniRef50_C0W593 DNA topoisomerase n=1 Tax=Actinomyces urogenital... 599 e-169 UniRef50_A4CJB9 DNA topoisomerase n=4 Tax=Bacteria RepID=A4CJB9_... 599 e-169 UniRef50_D0GKB0 DNA topoisomerase n=1 Tax=Leptotrichia goodfello... 599 e-169 UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2... 592 e-167 UniRef50_A6DJX4 DNA topoisomerase n=2 Tax=Bacteria RepID=A6DJX4_... 591 e-167 UniRef50_D1N8U4 DNA topoisomerase n=1 Tax=Victivallis vadensis A... 589 e-166 UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_... 587 e-166 UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms Re... 587 e-166 UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms Rep... 584 e-165 UniRef50_A8F3N1 DNA topoisomerase n=2 Tax=Thermotogaceae RepID=A... 581 e-164 UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=... 578 e-163 UniRef50_C7NA27 DNA topoisomerase n=20 Tax=Fusobacteriaceae RepI... 577 e-163 UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF... 573 e-162 UniRef50_A9BI47 DNA topoisomerase n=3 Tax=Thermotogaceae RepID=A... 573 e-161 UniRef50_C6XXX5 DNA topoisomerase n=76 Tax=Bacteria RepID=C6XXX5... 572 e-161 UniRef50_Q31J81 DNA topoisomerase n=6 Tax=Bacteria RepID=Q31J81_... 568 e-160 UniRef50_D2QCS0 DNA topoisomerase I n=1 Tax=Spirosoma linguale D... 567 e-160 UniRef50_Q13472 DNA topoisomerase 3-alpha n=31 Tax=Eumetazoa Rep... 567 e-160 UniRef50_A8EWX5 DNA topoisomerase I n=2 Tax=Campylobacterales Re... 566 e-159 UniRef50_Q6XZ01 DNA topoisomerase n=2 Tax=Spiroplasma RepID=Q6XZ... 566 e-159 UniRef50_C3JAB5 DNA topoisomerase n=3 Tax=Bacteria RepID=C3JAB5_... 566 e-159 UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J35... 563 e-159 UniRef50_A4RYV6 DNA topoisomerase (Fragment) n=5 Tax=cellular or... 563 e-159 UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6Y... 562 e-158 UniRef50_Q1AY08 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 562 e-158 UniRef50_O95985 DNA topoisomerase 3-beta-1 n=72 Tax=Eukaryota Re... 562 e-158 UniRef50_C1E9E3 DNA topoisomerase n=1 Tax=Micromonas sp. RCC299 ... 560 e-157 UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepI... 559 e-157 UniRef50_C6I107 DNA topoisomerase n=1 Tax=Leptospirillum ferrodi... 555 e-156 UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium bacul... 554 e-156 UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae Rep... 553 e-156 UniRef50_C7J0A2 DNA topoisomerase n=2 Tax=Magnoliophyta RepID=C7... 552 e-155 UniRef50_C5Z4V5 DNA topoisomerase (Fragment) n=12 Tax=cellular o... 550 e-155 UniRef50_D2VSX3 Predicted protein n=1 Tax=Naegleria gruberi RepI... 550 e-155 UniRef50_B7I2H2 DNA topoisomerase n=4 Tax=Proteobacteria RepID=B... 550 e-154 UniRef50_Q9LVP1 DNA topoisomerase n=6 Tax=Embryophyta RepID=Q9LV... 549 e-154 UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus cald... 549 e-154 UniRef50_Q185E5 DNA topoisomerase n=10 Tax=Clostridiales RepID=Q... 548 e-154 UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria R... 548 e-154 UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum aceto... 548 e-154 UniRef50_A1AXT2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A1AXT... 547 e-154 UniRef50_A8II62 DNA topoisomerase (Fragment) n=1 Tax=Chlamydomon... 543 e-153 UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=... 543 e-152 UniRef50_Q3M6J7 DNA topoisomerase n=12 Tax=Cyanobacteria RepID=Q... 542 e-152 UniRef50_B5TTQ4 TraB n=3 Tax=environmental samples RepID=B5TTQ4_... 541 e-152 UniRef50_B5JHP8 DNA topoisomerase n=2 Tax=Bacteria RepID=B5JHP8_... 541 e-152 UniRef50_C9KMQ0 DNA topoisomerase n=5 Tax=Bacteria RepID=C9KMQ0_... 540 e-152 UniRef50_B7J7I8 DNA topoisomerase I, putative n=1 Tax=Acidithiob... 538 e-151 UniRef50_A3EW25 DNA topoisomerase n=3 Tax=Leptospirillum RepID=A... 538 e-151 UniRef50_O34204 DNA topoisomerase 1 n=8 Tax=Thermotogaceae RepID... 538 e-151 UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris... 538 e-151 UniRef50_C8WG68 DNA topoisomerase type IA central domain protein... 537 e-151 UniRef50_Q18KP8 DNA topoisomerase n=6 Tax=Halobacteriaceae RepID... 537 e-151 UniRef50_A4I3Q5 DNA topoisomerase III, putative n=8 Tax=Trypanos... 536 e-151 UniRef50_A5FHK0 DNA topoisomerase III n=25 Tax=cellular organism... 536 e-150 UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK... 536 e-150 UniRef50_A3BAP2 DNA topoisomerase n=6 Tax=Poaceae RepID=A3BAP2_O... 535 e-150 UniRef50_C0A759 DNA topoisomerase n=4 Tax=Bacteria RepID=C0A759_... 535 e-150 UniRef50_P78032 DNA topoisomerase 1 n=2 Tax=Mycoplasma RepID=TOP... 534 e-150 UniRef50_B9LRP1 DNA topoisomerase n=4 Tax=Halobacteriaceae RepID... 533 e-150 UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapo... 533 e-150 UniRef50_B1M9R9 DNA topoisomerase I n=4 Tax=root RepID=B1M9R9_METRJ 533 e-150 UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boo... 533 e-150 UniRef50_B1VAJ5 DNA topoisomerase n=6 Tax=Acholeplasmataceae Rep... 533 e-149 UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3... 532 e-149 UniRef50_Q9U286 DNA topoisomerase n=3 Tax=Bilateria RepID=Q9U286... 532 e-149 UniRef50_Q3BT95 DNA topoisomerase n=14 Tax=Gammaproteobacteria R... 532 e-149 UniRef50_B2RH95 DNA topoisomerase III n=3 Tax=Bacteroidales RepI... 532 e-149 UniRef50_UPI0001C314B9 DNA topoisomerase III n=1 Tax=Conexibacte... 530 e-149 UniRef50_D0LL88 DNA topoisomerase n=1 Tax=Haliangium ochraceum D... 530 e-148 UniRef50_C3QFV7 DNA topoisomerase III n=28 Tax=Bacteroidales Rep... 529 e-148 UniRef50_C5B550 DNA topoisomerase n=1 Tax=Methylobacterium extor... 529 e-148 UniRef50_B7AD12 Putative uncharacterized protein n=4 Tax=Bactero... 528 e-148 UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermo... 528 e-148 UniRef50_Q8T2T7 DNA topoisomerase 3 n=1 Tax=Dictyostelium discoi... 528 e-148 UniRef50_Q21RE9 DNA topoisomerase III n=34 Tax=Bacteria RepID=Q2... 528 e-148 UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP... 527 e-148 UniRef50_Q9NG98 DNA topoisomerase 3-alpha n=10 Tax=Eukaryota Rep... 526 e-147 UniRef50_C6XEP4 DNA topoisomerase I n=1 Tax=Methylovorus sp. SIP... 526 e-147 UniRef50_A4HPI6 DNA topoisomerase n=9 Tax=Trypanosomatidae RepID... 525 e-147 UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophil... 525 e-147 UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0... 525 e-147 UniRef50_O66893 DNA topoisomerase 1 n=2 Tax=Aquificaceae RepID=T... 524 e-147 UniRef50_A4BJY7 Topoisomerase I n=1 Tax=Reinekea blandensis MED2... 523 e-146 UniRef50_A5ZSZ0 DNA topoisomerase n=12 Tax=Bacteria RepID=A5ZSZ0... 523 e-146 UniRef50_A3FPU5 DNA topoisomerase n=3 Tax=Cryptosporidium RepID=... 523 e-146 UniRef50_Q9HM08 DNA topoisomerase 1 n=4 Tax=Thermoplasmatales Re... 522 e-146 UniRef50_C1LZJ7 Prokaryotic DNA topoisomerase, putative n=1 Tax=... 522 e-146 UniRef50_A3DB61 DNA topoisomerase n=1 Tax=Shewanella baltica OS1... 522 e-146 UniRef50_C7H9Z3 DNA topoisomerase n=32 Tax=Firmicutes RepID=C7H9... 522 e-146 UniRef50_A1U3N5 DNA topoisomerase n=6 Tax=Gammaproteobacteria Re... 522 e-146 UniRef50_UPI00006CC0A9 DNA topoisomerase family protein n=1 Tax=... 521 e-146 UniRef50_Q8EVZ3 DNA topoisomerase n=1 Tax=Mycoplasma penetrans R... 519 e-145 UniRef50_D1BLQ5 DNA topoisomerase n=3 Tax=Veillonella RepID=D1BL... 519 e-145 UniRef50_Q7Q111 DNA topoisomerase n=3 Tax=Endopterygota RepID=Q7... 519 e-145 UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae ... 519 e-145 UniRef50_A1TJM5 DNA topoisomerase n=55 Tax=Proteobacteria RepID=... 518 e-145 UniRef50_B6ADG7 DNA topoisomerase n=1 Tax=Cryptosporidium muris ... 518 e-145 UniRef50_Q5ZHE3 DNA topoisimerase n=9 Tax=root RepID=Q5ZHE3_9BACT 518 e-145 UniRef50_B1AJN1 DNA topoisomerase I n=15 Tax=Ureaplasma RepID=B1... 518 e-145 UniRef50_Q5WAX6 DNA topoisomerase 3 n=137 Tax=Bacteria RepID=TOP... 517 e-145 UniRef50_B1X1Z5 DNA topoisomerase n=3 Tax=Chroococcales RepID=B1... 517 e-145 UniRef50_C4V616 DNA topoisomerase n=1 Tax=Selenomonas flueggei A... 517 e-145 UniRef50_C0YH06 DNA topoisomerase n=4 Tax=Bacteroidetes RepID=C0... 516 e-144 UniRef50_A8MIQ9 DNA topoisomerase n=2 Tax=Clostridiaceae RepID=A... 516 e-144 UniRef50_UPI0001C41D8C DNA topoisomerase I TopA n=1 Tax=Methanob... 516 e-144 UniRef50_C6N6E9 DNA topoisomerase n=2 Tax=Legionella drancourtii... 515 e-144 UniRef50_UPI0000DB782E PREDICTED: similar to topoisomerase (DNA)... 515 e-144 UniRef50_B7KK14 DNA topoisomerase n=4 Tax=Cyanobacteria RepID=B7... 515 e-144 UniRef50_Q9PHK2 DNA topoisomerase I, plasmid n=3 Tax=Gammaproteo... 515 e-144 UniRef50_Q18AW1 DNA topoisomerase n=19 Tax=Bacteria RepID=Q18AW1... 514 e-144 UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C... 513 e-144 UniRef50_C0FN62 DNA topoisomerase n=31 Tax=Bacteria RepID=C0FN62... 513 e-143 UniRef50_A6GUS8 DNA topoisomerase n=1 Tax=Limnobacter sp. MED105... 513 e-143 UniRef50_B1ZYV6 DNA topoisomerase n=11 Tax=Bacteria RepID=B1ZYV6... 512 e-143 UniRef50_D1W4E5 DNA topoisomerase n=30 Tax=Bacteroidales RepID=D... 512 e-143 UniRef50_O28469 DNA topoisomerase 1 n=8 Tax=Euryarchaeota RepID=... 511 e-143 UniRef50_P14294 DNA topoisomerase 3 n=211 Tax=Gammaproteobacteri... 511 e-143 UniRef50_C1MSJ2 DNA topoisomerase n=1 Tax=Micromonas pusilla CCM... 511 e-143 UniRef50_UPI000186EA7F DNA topoisomerase 3-alpha, putative n=1 T... 511 e-143 UniRef50_C9LK04 DNA topoisomerase III n=3 Tax=Prevotella RepID=C... 510 e-143 UniRef50_B7JBJ6 DNA topoisomerase III n=3 Tax=Acidithiobacillus ... 510 e-143 UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU... 510 e-142 UniRef50_Q12Y06 DNA topoisomerase n=1 Tax=Methanococcoides burto... 510 e-142 UniRef50_Q9KQF5 DNA topoisomerase 3 n=109 Tax=Gammaproteobacteri... 509 e-142 UniRef50_A4JW73 DNA topoisomerase n=1 Tax=Burkholderia vietnamie... 509 e-142 UniRef50_C7HY28 DNA topoisomerase III n=1 Tax=Thiomonas intermed... 509 e-142 UniRef50_A0CUH3 Chromosome undetermined scaffold_28, whole genom... 508 e-142 UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 508 e-142 UniRef50_C6BT42 DNA topoisomerase type IA central domain protein... 507 e-142 UniRef50_C0FPK2 Putative uncharacterized protein n=3 Tax=Clostri... 507 e-142 UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula ... 507 e-142 UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infe... 507 e-142 UniRef50_D0NZ98 DNA topoisomerase, putative n=1 Tax=Phytophthora... 506 e-141 UniRef50_Q9JN65 DNA topoisomerase 1 n=2 Tax=Mycoplasma gallisept... 506 e-141 UniRef50_B6KEM8 DNA topoisomerase n=2 Tax=Toxoplasma gondii RepI... 506 e-141 UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribac... 506 e-141 UniRef50_Q55KM2 DNA topoisomerase n=3 Tax=Agaricomycotina RepID=... 505 e-141 UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogen... 505 e-141 UniRef50_B3JMI8 DNA topoisomerase n=15 Tax=Bacteria RepID=B3JMI8... 505 e-141 UniRef50_C1DYX0 Predicted protein n=4 Tax=Viridiplantae RepID=C1... 505 e-141 UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina E... 505 e-141 UniRef50_Q01NZ0 DNA topoisomerase n=2 Tax=Acidobacteria RepID=Q0... 504 e-141 UniRef50_B8G1K2 DNA topoisomerase n=2 Tax=Desulfitobacterium haf... 504 e-141 UniRef50_D0JAY2 DNA topoisomerase n=2 Tax=Blattabacterium RepID=... 504 e-141 UniRef50_C5PM09 Possible DNA topoisomerase n=1 Tax=Sphingobacter... 504 e-141 UniRef50_Q5NWJ2 DNA topoisomerase n=31 Tax=root RepID=Q5NWJ2_AZOSE 503 e-140 UniRef50_A8XHL1 DNA topoisomerase n=2 Tax=Caenorhabditis briggsa... 503 e-140 UniRef50_Q04TE1 DNA topoisomerase n=4 Tax=Leptospira RepID=Q04TE... 503 e-140 UniRef50_Q1QVL1 DNA topoisomerase n=1 Tax=Chromohalobacter salex... 503 e-140 UniRef50_A4JFS2 DNA topoisomerase III n=4 Tax=Proteobacteria Rep... 502 e-140 UniRef50_Q5HLZ4 DNA topoisomerase 3 n=9 Tax=Staphylococcus RepID... 501 e-140 UniRef50_B0EMC7 DNA topoisomerase 3-alpha, putative n=2 Tax=Enta... 501 e-140 UniRef50_B1HX02 DNA topoisomerase III n=93 Tax=Bacillaceae RepID... 500 e-140 UniRef50_A1U7T2 DNA topoisomerase I n=2 Tax=Marinobacter RepID=A... 500 e-139 UniRef50_C7DGI7 DNA topoisomerase n=1 Tax=Candidatus Micrarchaeu... 499 e-139 UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=... 499 e-139 UniRef50_Q099E1 Topoisomerase B n=1 Tax=Stigmatella aurantiaca D... 498 e-139 UniRef50_C6XWV5 DNA topoisomerase type IA central domain protein... 497 e-139 UniRef50_C9LWM4 DNA topoisomerase n=1 Tax=Selenomonas sputigena ... 496 e-138 UniRef50_A2QNT8 DNA topoisomerase n=36 Tax=Leotiomyceta RepID=A2... 496 e-138 UniRef50_O61660 DNA topoisomerase 3 n=2 Tax=Chromadorea RepID=TO... 496 e-138 UniRef50_A8U7S1 DNA topoisomerase n=2 Tax=Lactobacillales RepID=... 495 e-138 UniRef50_Q5UQB5 DNA topoisomerase 1 type prokaryotic n=1 Tax=Aca... 495 e-138 UniRef50_B2V7T0 DNA topoisomerase I n=5 Tax=Aquificales RepID=B2... 495 e-138 UniRef50_B2RGV8 DNA topoisomerase I n=47 Tax=Bacteroidetes RepID... 494 e-138 UniRef50_A7I6L6 DNA topoisomerase n=5 Tax=Methanomicrobiales Rep... 494 e-138 Sequences not found previously or not previously below threshold: >UniRef50_Q9KRB2 DNA topoisomerase 1 n=401 Tax=cellular organisms RepID=TOP1_VIBCH Length = 876 Score = 899 bits (2322), Expect = 0.0, Method: Composition-based stats. Identities = 610/869 (70%), Positives = 719/869 (82%), Gaps = 10/869 (1%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 MGK+LVIVESPAKAKTINKYLG D++VKSSVGH+RDLPT+G A + + + T K Sbjct: 1 MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTAGQTATPTGKAAAASTKKAST 60 Query: 61 KDERGALV--------NRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 D+ +MGVDP+H W+A+Y++LPGKEKVV+EL++LA+ AD +YLATDL Sbjct: 61 TDKEQQKREKERAALIKKMGVDPYHGWQANYQILPGKEKVVAELQKLAKDADSVYLATDL 120 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 DREGEAIAWHLRE+IGGD+ RY RVVFNEITKNAI+QAF +PGELN+D VNAQQARRFMD Sbjct: 121 DREGEAIAWHLREIIGGDEKRYKRVVFNEITKNAIQQAFKQPGELNMDGVNAQQARRFMD 180 Query: 173 RVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE 232 RVVG+MVSPLLWKK+ARGLSAGRVQSVAV+L+VEREREIKAFVPEEFW+++A T T + Sbjct: 181 RVVGFMVSPLLWKKVARGLSAGRVQSVAVKLLVEREREIKAFVPEEFWDINADTLTADKQ 240 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 L V ++ F+PVN+ + AAV+ L KA+Y V +REDKPTTSKP APFITSTLQQA Sbjct: 241 DFRLLVAQKDGLAFKPVNETEALAAVAALNKAQYEVCKREDKPTTSKPSAPFITSTLQQA 300 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 ASTRLG+GVKKTMM+AQRLYEAGYITYMRTDSTNLS +AV +RGYI+ ++G+ YLP P Sbjct: 301 ASTRLGYGVKKTMMLAQRLYEAGYITYMRTDSTNLSAEAVENLRGYITKHYGEAYLPSQP 360 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 N Y SK+N+QEAHEAIRPSDV V A+ L+ MEADA KLY LIW QFVACQMTPA+YDSTT Sbjct: 361 NVYGSKQNAQEAHEAIRPSDVTVTADDLEGMEADAHKLYALIWNQFVACQMTPAQYDSTT 420 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 ++V A ++ LKA+GRIL+FDGWT+V L K ED+ILP V GD+L LV L P QHFTK Sbjct: 421 VSVKAAEYTLKAKGRILKFDGWTRVQRPLGKN-EDQILPPVKVGDSLKLVSLDPKQHFTK 479 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PPAR++EA+LVKELEKRGIGRPSTYASIISTIQDRGYV+V+ RRF+AEKMGEIVTDRL+E Sbjct: 480 PPARYTEAALVKELEKRGIGRPSTYASIISTIQDRGYVKVDQRRFFAEKMGEIVTDRLDE 539 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 NF +LMNYDFTA+ME LDQ+A E W AVLD FF+DF++ L+ AE+D GGM+PN + Sbjct: 540 NFDDLMNYDFTARMEEKLDQIAEGEVNWTAVLDEFFADFSRDLETAEQDESLGGMKPNHI 599 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 V+T+I CPTC R MGIRTASTGVFLGCSGY LPPKERCKTTINL E V+NVLE ED E Sbjct: 600 VMTNILCPTCSRPMGIRTASTGVFLGCSGYGLPPKERCKTTINLGDEEGVINVLE-EDVE 658 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 T ALRAK+RCP C TAMD+YLID KRKLHVCGNNP C+G+ +EEGEF++KGY+GP VEC+ Sbjct: 659 TAALRAKKRCPICETAMDAYLIDDKRKLHVCGNNPNCEGFIVEEGEFKVKGYEGPTVECD 718 Query: 713 KCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL 772 KCGS+M LK GRFGKYM CTN+ CKNTRKIL+NGEVAPPKE+PV PELPCE SDAYFVL Sbjct: 719 KCGSDMVLKNGRFGKYMGCTNDACKNTRKILKNGEVAPPKEEPVHFPELPCENSDAYFVL 778 Query: 773 RDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFS 832 RDGA+G+F AA+ FPKSRETRAPLVEEL RF +RLPEK +YL AP DP+G +VRFS Sbjct: 779 RDGASGLFFAASNFPKSRETRAPLVEELKRFAERLPEKYQYLTSAPAHDPDGLPAVVRFS 838 Query: 833 RKTKQQYVSSEKDGKATGWSAFYVDGKWV 861 RK K+ YV +E +GK +GW A Y +GKW+ Sbjct: 839 RKEKEHYVRTETEGKPSGWMAVYQEGKWL 867 >UniRef50_Q8K9P7 DNA topoisomerase 1 n=2 Tax=Gammaproteobacteria RepID=TOP1_BUCAP Length = 853 Score = 759 bits (1960), Expect = 0.0, Method: Composition-based stats. Identities = 447/862 (51%), Positives = 613/862 (71%), Gaps = 16/862 (1%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+LVIVESP KAKTI+KYLG Y+VKSSVGH+RDL + + K Sbjct: 1 MCKSLVIVESPVKAKTISKYLGKQYIVKSSVGHVRDL------INNKSKNKKNIKKSNIK 54 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +E+ AL+ +MG++P+ NW+A Y +LPGKEK++SELK +A K +IYLATDLDREGEAIA Sbjct: 55 HNEKTALIQQMGINPYKNWKAEYHILPGKEKIISELKNIANKVHYIYLATDLDREGEAIA 114 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+EVIGG+ ++ RVVFNEITK +I +AF G++N++RV +QQARRFMDR+VGYM+S Sbjct: 115 WHLKEVIGGNSLKFRRVVFNEITKKSIEKAFQNIGKINMNRVYSQQARRFMDRIVGYMIS 174 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWKKI+RGLSAGRVQS AVRL+ +RE EIK F+ E W++ S + + + + +TH Sbjct: 175 PLLWKKISRGLSAGRVQSAAVRLITDREYEIKNFIEREHWKISLSLLSKENKKVTMDITH 234 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 +K F NK++ + + ++ + + +R+DK KP AP ITSTLQQA++ LGF Sbjct: 235 YRNKTFLLNNKKEVNSTIEKIKNLSFIITDRKDKIFKKKPPAPLITSTLQQASNIDLGFS 294 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 VKKTM +AQ+LYE GYITY+RTDS LS A+ VR YI + +G +LP+ N Y++++ Sbjct: 295 VKKTMFLAQKLYEQGYITYIRTDSYFLSNYAIEKVRSYIENFYGSDFLPKKSNIYSNQKY 354 Query: 361 SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF 420 SQEAHEAIRPSDV V+ ++ + + DA+KLY+LIW F+A QM +Y S TV A F Sbjct: 355 SQEAHEAIRPSDVQVV--NIDNCDPDAKKLYKLIWNYFIASQMKSERYKSIKTTVMADVF 412 Query: 421 RLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEA 480 +L++ +I+ F GWTK++ + + + P ++ G L L ++ P Q FTKPP RFSE+ Sbjct: 413 KLQSNTKIVLFSGWTKILK--KSNNVNFKFPVLDIGTTLILDKILPHQIFTKPPPRFSES 470 Query: 481 SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY 540 SLV+ELEK+GIGRPSTYA+II+ I+++GY++++ +FYA K+GEI+ RL++NF +L++Y Sbjct: 471 SLVRELEKKGIGRPSTYATIITKIKEKGYLKIKKNKFYAAKIGEILITRLKKNFSDLVDY 530 Query: 541 DFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP 600 DFTA+ME +LDQV++ WK +L+ FF +F+QQL++A+K PEEGGM N V T IDC Sbjct: 531 DFTARMEKNLDQVSDKLINWKHLLNSFFDNFSQQLEQAKKPPEEGGMELNTTVPTEIDCS 590 Query: 601 TCGRKMGIRTASTGVFLGCSGYALPPKER-CKTTINLVPENEVLNVLEGEDAETNALRAK 659 C +KMGI+TA TGVFL C GY P E+ CK TINL+ LN L E K Sbjct: 591 LCNKKMGIKTAVTGVFLSCLGYNSEPNEKRCKNTINLI----SLNDLSTTKKEEKNFHLK 646 Query: 660 RRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEE-GEFRIKGYDGPIVECEKCGSEM 718 RC KC MD YLI+ K+ +C NNP+C+GY +++ + ++CEKC ++M Sbjct: 647 NRCKKCNLVMDVYLINENLKIFICINNPSCNGYNLKKGIFKKSLNCSLKKIKCEKCKNDM 706 Query: 719 HLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG 778 K GRFG + C N+ CKNTRKIL NGE++ PK +P+P P++ CEKS+ +FVLR+G +G Sbjct: 707 LFKTGRFGNFFMCINDTCKNTRKILPNGEISEPKFEPIPFPDILCEKSNTWFVLREGISG 766 Query: 779 VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQ 838 +F AANTFPKSRETR+P VEEL RF LP+KL YLA APQ+D +GNKT+V F++ KQQ Sbjct: 767 IFFAANTFPKSRETRSPFVEELARFEYLLPKKLHYLASAPQRDNKGNKTIVCFNKLNKQQ 826 Query: 839 YVSSEKDGKATGWSAFYVDGKW 860 Y++S+K+GK TGW+AF++D KW Sbjct: 827 YIASKKEGKFTGWAAFFIDRKW 848 >UniRef50_Q1ILA9 DNA topoisomerase n=9 Tax=Bacteria RepID=Q1ILA9_ACIBL Length = 853 Score = 730 bits (1885), Expect = 0.0, Method: Composition-based stats. Identities = 319/831 (38%), Positives = 451/831 (54%), Gaps = 88/831 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI KYLG Y V++S+GHI+DLP G Sbjct: 1 MAKGLVIVESPAKAKTIQKYLGKGYEVEASLGHIKDLPKKG------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD +N++ Y V+PGKEKVV++LK+LA+ AD IYLA D DREGEAIA Sbjct: 42 ----------LGVDIENNFDTEYVVIPGKEKVVAKLKKLAKDADAIYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDA---------RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFM 171 HL E +G D + RV FNEITK A+++AF KP E++ + V+AQQ RR + Sbjct: 92 AHLAEELGDGDGKKKKKTDSKPFYRVTFNEITKKAVQEAFAKPREIDRNLVDAQQTRRIL 151 Query: 172 DRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 DR+VG+ VSPLLW K+ RGLSAGRVQ+VA+RL+VEREREIKAFV +E+W +DA Sbjct: 152 DRLVGFQVSPLLWDKVRRGLSAGRVQTVALRLIVEREREIKAFVSKEYWTIDAHLHGQKP 211 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + T + + N+E+++ V L+ A +SV +++ APF TS QQ Sbjct: 212 PDFDARFTGIDGEKLEVGNEEESKKIVDQLDNAEWSVRSVDNRERRRNAAAPFTTSKFQQ 271 Query: 292 AASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 AS +LG VK+ MM+AQ LYE G ITYMRTDST +S +A+ VR I + Sbjct: 272 DASRKLGMSVKRAMMIAQHLYEGVELGEEGTVGLITYMRTDSTRVSNEALTEVRELIGTS 331 Query: 343 FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 +G ++LPESPN Y K+++Q AHEAIRPS V + LK ++ D K+Y+LIW++FVA Sbjct: 332 YGPQFLPESPNVYKQKKDAQGAHEAIRPSSVAHTPDDLKAYLKDDEMKVYKLIWQRFVAS 391 Query: 402 QMTPAKYDSTTLTVGAG---DFRLKARGRILRFDGWTKVMPALRKGDEDR------ILPA 452 QM PA +D TT+ + A + + G +L+F+G+ KV ++G ++ LP Sbjct: 392 QMAPAVFDQTTVDIDAKADRTYNFRVTGSVLKFEGFLKVYEESKEGKDEEDDALKHKLPP 451 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 + +G LTL + P QHFT+PP R++EASLVKELE++GIGRPSTYA+I+STIQDRGYV+ Sbjct: 452 LVEGQTLTLKAIKPEQHFTEPPPRYNEASLVKELEEQGIGRPSTYAAILSTIQDRGYVQK 511 Query: 513 ---ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 +F+ ++G +VTD L NF+++ + FT++ME LD+V + + +W L F+ Sbjct: 512 TPGRGGKFFPTEIGMVVTDLLVANFKDIFDTKFTSRMEEELDEVEDGQKKWTDTLKEFYD 571 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 F LD A+K E T C CG + I+ G F CS Y Sbjct: 572 KFETNLDYAQKHMENIKR---MEKPTDEKCERCGSPLVIKWGKHGSFYACSSYDKKDPNS 628 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 C T +++ + + A+ + C CG M + C P C Sbjct: 629 CTFTK-----ENPIDLPDLDTADVQETEQEEYCENCGRGMVLKR-GRFGQFMACTGYPEC 682 Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEV 748 + +I +C +C + L+ GRFG++++C+ ECK ++ Sbjct: 683 KTTRRLDQAKKI-PDVPLDEKCPECTRPLVLRHGRFGEFVSCSGYPECKWIKQNF----- 736 Query: 749 APPKEDPVPLPELPCEKSD-AYFVLRDGAAG-VFLAANTFPKSRETRAPLV 797 + C + V + G F +PK T A Sbjct: 737 ----------VGVKCPQCKEGEIVEKKARRGNFFYGCARYPKCDFTSANKP 777 Score = 48.9 bits (115), Expect = 9e-04, Method: Composition-based stats. Identities = 12/79 (15%), Positives = 27/79 (34%), Gaps = 1/79 (1%) Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAP 818 + CE+ + V++ G G F A +++ K +E L + Sbjct: 594 TDEKCERCGSPLVIKWGKHGSFYACSSYDKKDPNSCTFTKENPIDLPDLDTADVQETEQE 653 Query: 819 QQD-PEGNKTMVRFSRKTK 836 + G +++ R + Sbjct: 654 EYCENCGRGMVLKRGRFGQ 672 >UniRef50_C1SMY2 DNA topoisomerase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SMY2_9BACT Length = 782 Score = 724 bits (1868), Expect = 0.0, Method: Composition-based stats. Identities = 307/826 (37%), Positives = 442/826 (53%), Gaps = 65/826 (7%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKA+TI KYLG ++ V +SVGH++DLP Sbjct: 1 MPKNLVIVESPAKARTIEKYLGRNFKVLASVGHVKDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + +GVD +++E Y ++ GK+K++ ELK++A A++IYLA D DREGEAIA Sbjct: 39 -------ASSLGVDLDNDFEPKYSIIRGKKKIIDELKKVANSAENIYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDA-RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ E +G + + RV+FNEITK I G +N +R NAQQARR +DR+VGY+V Sbjct: 92 WHIAEELGKKNKGKIYRVLFNEITKKGIEDGIKNTGPINENRTNAQQARRILDRLVGYLV 151 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SPLLWK + GLSAGRVQSVA+RL+VERE EI+ F PEE+W +D + L ++ Sbjct: 152 SPLLWKSLKYGLSAGRVQSVALRLLVEREEEIEKFKPEEYWLIDVTFKGGQKALLKARLE 211 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 +N K +R N E+ +A ++ L+ Y+V E K + PFITS LQQ A+ +L F Sbjct: 212 KKNGKKYRVPNGEEAEAVLAALKAGSYNVNEVIRKEVFERAPLPFITSKLQQEAARKLSF 271 Query: 300 GVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 K+TMM+AQRLYE G ITYMRTDST +S DA N RGYI +GK++L + Sbjct: 272 SAKRTMMLAQRLYEGIELGSEGPVGLITYMRTDSTRVSPDATNEARGYIEKQYGKEFLSK 331 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 + K+N Q+AHEAIRP+ V + ES+K ++ D KLY+LIW +FV+ M A YD Sbjct: 332 GVKGGSKKKNVQDAHEAIRPTSVAITPESVKKILDTDQYKLYKLIWDRFVSSNMADAVYD 391 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVMPA---LRKGDEDRILPAVNKGDALTLVELTP 466 T+ + G + LK++G++++F G+ + K + ++ V +G+ L + Sbjct: 392 QNTIHIANGPYLLKSQGKVMKFPGFQTLYIEGVDESKEKDQEVIFDVKEGETLNPEKHDS 451 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 Q FT+PPAR+SEA+LVK LE GIGRPSTYASIIST+ DR Y +E +RF ++G +V Sbjct: 452 KQMFTQPPARYSEATLVKTLEAEGIGRPSTYASIISTLIDREYANMEEKRFKPTELGRVV 511 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG 586 L NF + FTA ME LD V E WK VL F++ F +L+KAEK Sbjct: 512 CSLLIANFDRIFEPKFTAGMEEDLDSVEAGELTWKGVLRDFYAKFKPELEKAEK------ 565 Query: 587 MRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVL 646 + + + + CP C + + I+ G F+ C+ Y CK T N + L Sbjct: 566 -QFSANLKIEMKCPVCEKDLTIKYGRNGNFVACTSYP-----ECKFTSNYERLEDGSFKL 619 Query: 647 EGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFR-----I 701 + + C KCG + ++ C P C + + Sbjct: 620 ---VPKEEDKPSGIECEKCGKELVFKKTRFG-EVLACPGYPECKNIKNYVTLPDGEIKIL 675 Query: 702 KGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPE 760 + C KC + + +K GR G ++ C N +C T + N + + Sbjct: 676 AAGEEIGTPCPKCEAGLTIKGGRNGMFIGCKNYPDCDFTANMEVNEQGDIIPKYDKVDEN 735 Query: 761 LPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDR 806 + CEK VL+ G F A +P+ + ++ +V E + Sbjct: 736 VKCEKCGKPMVLKKSRRGKFFACTGYPECKNAKSTIVLEDGTISVK 781 >UniRef50_A7NJW2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A7NJW2_ROSCS Length = 836 Score = 719 bits (1855), Expect = 0.0, Method: Composition-based stats. Identities = 307/807 (38%), Positives = 432/807 (53%), Gaps = 83/807 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 MG+ LVIVESPAKA+TI KYLGS Y V++S+GH+RDLP Sbjct: 1 MGEKLVIVESPAKARTIQKYLGSGYRVEASMGHVRDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + +GVD N+ YE+ PGKEK+++ L++ +AD +YLATD DREGEAIA Sbjct: 39 -------KSNLGVDLEANFAPVYEISPGKEKIIAALRKSIRQADAVYLATDPDREGEAIA 91 Query: 121 WHLREVIG-GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ E D RVVF EIT A+R A P +++ V+AQQARR +DR+VGY + Sbjct: 92 WHITEAAKIPRDKPVYRVVFTEITPGAVRSAMASPRDIDRRLVDAQQARRVLDRLVGYKL 151 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-----EAL 234 SPLLW+K+ RGLSAGRVQSVAVRL+VEREREI+AFVP+E+W ++A + +A Sbjct: 152 SPLLWEKVRRGLSAGRVQSVAVRLIVEREREIEAFVPQEYWTIEADLLKQNASDSQRDAF 211 Query: 235 ALQVTHQNDKPFRPVNK---EQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + ++ K + +Q QA ++ LE A Y V + + P PF TSTLQQ Sbjct: 212 RAMLIERSGKKLEKFDIGASDQAQAIIADLEGAAYIVRKVTRRDKRRSPAPPFTTSTLQQ 271 Query: 292 AASTRLGFGVKKTMMMAQRLYEA----------GYITYMRTDSTNLSQDAVNMVRGYISD 341 A +LGF K+TM +AQ+LYE G ITYMRTDS N+S++A R I + Sbjct: 272 EAGRKLGFSAKRTMAVAQQLYEGVDIGGDEGLVGLITYMRTDSVNVSREAQEEARRVIRE 331 Query: 342 NFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFV 399 FG+ YLP P Y +K + +QEAHEAIRP+ E ++ + +D +LY LIW++FV Sbjct: 332 RFGEAYLPAKPPVYKTKAKGAQEAHEAIRPTLSRRTPEQVQPYLTSDQYRLYDLIWKRFV 391 Query: 400 ACQMTPAKYDSTTLTVGAG-----------DFRLKARGRILRFDGWTKVMP-----ALRK 443 A QM A +DST + +GAG + +A G +L+F G+ V Sbjct: 392 ASQMEAAVFDSTVVDIGAGRDIGGRGAGSDPYTFRATGSVLKFPGFLAVYNVSLDEGEED 451 Query: 444 GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 503 D +R LP + +G+AL L++L P QHFT+PP RF+EASLVKELE+ GIGRPSTYA IST Sbjct: 452 EDSERRLPLLEEGEALNLLQLLPVQHFTEPPPRFTEASLVKELERLGIGRPSTYAPTIST 511 Query: 504 IQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 I +R YV + +++ +G +VTD L E+F +++Y FT++ME LD +A E EW V Sbjct: 512 IIEREYVELADKKLVPTTLGRVVTDLLVEHFPSIVDYGFTSEMEQQLDDIAEGEKEWAPV 571 Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK-MGIRTASTGVFLGCSGY 622 L F+ F Q+L +A++ +LT + CP C + + ++ G FL C+ Y Sbjct: 572 LRAFYRPFEQKLAEAQRSMRNVKREE---ILTDLTCPRCNQGQLAVKFGRNGEFLACNRY 628 Query: 623 ALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHV 682 C T + +++ VL+ + + C CG M Sbjct: 629 P-----ECDFTSDFHRDSDGRIVLDAPAS---PETSDVLCDVCGRPMILKKSRFG-PFLG 679 Query: 683 CGNNPTCDGYEIEEGEFRIKGYDG-PIVECEKCG-SEMHLKMGRFG-KYMACTN-EECKN 738 C P C + + + V C KCG E+ + G+FG + C +C Sbjct: 680 CSGYPECKNTRRLDKQGKPAPLPKATGVTCPKCGQGELLERRGKFGRPFFGCNRYPKCDY 739 Query: 739 TRKILRNGEVAPPKEDPVPLPELPCEK 765 L P + P+ Sbjct: 740 LVNSLDEVAHYTPDANEASKPQAEEPT 766 Score = 114 bits (285), Expect = 2e-23, Method: Composition-based stats. Identities = 41/189 (21%), Positives = 63/189 (33%), Gaps = 14/189 (7%) Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFR-------IKGY 704 + + CP+C + + C P CD + Sbjct: 594 KREEILTDLTCPRCNQGQLAVKFGRNGEFLACNRYPECDFTSDFHRDSDGRIVLDAPASP 653 Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPC 763 + V C+ CG M LK RFG ++ C+ ECKNTR++ + G+ AP + + C Sbjct: 654 ETSDVLCDVCGRPMILKKSRFGPFLGCSGYPECKNTRRLDKQGKPAPLPKAT----GVTC 709 Query: 764 EKSD-AYFVLRDGAAG-VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQD 821 K + R G G F N +PK L E + D + D Sbjct: 710 PKCGQGELLERRGKFGRPFFGCNRYPKCDYLVNSLDEVAHYTPDANEASKPQAEEPTATD 769 Query: 822 PEGNKTMVR 830 + R Sbjct: 770 AKATPARKR 778 Score = 91.3 bits (225), Expect = 1e-16, Method: Composition-based stats. Identities = 24/151 (15%), Positives = 51/151 (33%), Gaps = 11/151 (7%) Query: 697 GEFRIKGYDGPIVECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRN--GEVAPPK 752 + + C +C ++ +K GR G+++AC EC T R+ G + Sbjct: 590 MRNVKREEILTDLTCPRCNQGQLAVKFGRNGEFLACNRYPECDFTSDFHRDSDGRIVLDA 649 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLR 812 ++ C+ +L+ G FL + +P+ + TR + P L Sbjct: 650 PASPETSDVLCDVCGRPMILKKSRFGPFLGCSGYPECKNTRRLD-------KQGKPAPLP 702 Query: 813 YLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 + + R + + + + Sbjct: 703 KATGVTCPKCGQGELLERRGKFGRPFFGCNR 733 >UniRef50_B5EJ79 DNA topoisomerase n=61 Tax=Proteobacteria RepID=B5EJ79_ACIF5 Length = 851 Score = 706 bits (1822), Expect = 0.0, Method: Composition-based stats. Identities = 295/819 (36%), Positives = 412/819 (50%), Gaps = 102/819 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG D+ V +S GH+RDL Sbjct: 1 MAHQLVIVESPAKAKTIQKYLGDDFQVLASYGHVRDLQPKEG------------------ 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VD H++ Y + E+ V + + AD ++LATD DREGEAI+ Sbjct: 43 -----------AVDTEHDFAMRYTPIERNERHVDAIAKALRGADKLWLATDPDREGEAIS 91 Query: 121 WHLREVIGGD----DARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WHL E++ D RVVF+EITK A+++A P E+ +D VNAQQARR +D +VG Sbjct: 92 WHLVELLRERQLLGDKPTQRVVFHEITKKAVQEAIAHPREIAMDLVNAQQARRALDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 + +SPLLW+K+ GLSAGRVQS A+RL+ ERE EI+AFV E+W + + Sbjct: 152 FNLSPLLWRKVRPGLSAGRVQSAALRLICERENEIEAFVSREYWTIASRLQHAGSAFTGR 211 Query: 237 QVTHQNDK--PFRPVNKEQTQAA----VSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 QN K F + +Q QA L + V E E K +P APF TSTLQ Sbjct: 212 LTHWQNKKLEQFDIADGDQAQAIRSGMEDDLGRQALRVREVERKSRQRQPAAPFTTSTLQ 271 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 Q AS +LGF +TM +AQ+LYE G I+YMRTD+ NL+++A+ +R +I Sbjct: 272 QEASRKLGFNASRTMRVAQQLYEGINIGNETVGLISYMRTDAVNLAEEAIASIRTFIDGY 331 Query: 343 FGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVA 400 +G +++PE+P +Y +K +N+QEAHEAIRP+D+ ESL+ +E D +LY L+W++ +A Sbjct: 332 YGSEFVPETPRRYKTKTKNAQEAHEAIRPTDIARTPESLQGVLERDLWRLYDLVWKRSIA 391 Query: 401 CQMTPAKYDSTTLTVGAGDF-RLKARGRILRFDGWTKVMPALRKGDED----RILPAVNK 455 CQM PA+ D + + AG L+A G + F G+ V + ++ RILP ++ Sbjct: 392 CQMAPARLDLVAVDMDAGTHWTLRANGSTVTFPGFMAVYQEGKDDGDEDESNRILPPLDV 451 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 GD ++ + P QHFT+PP R+S+A+LVK LE GIGRPSTYASII T+Q+R YV VE R Sbjct: 452 GDEPLVLGIDPEQHFTEPPPRYSDATLVKTLEAHGIGRPSTYASIIQTLQNREYVAVEQR 511 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 RF+ +G +V L +F ++Y FTA ME+ LD V+ E +W+ VL F+S F L Sbjct: 512 RFHPTDLGRVVGRFLINHFERYVDYGFTASMEDELDAVSRGEKQWQPVLSAFWSPFRALL 571 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 D+ CP CG+ + +R G F+ CSGY C T Sbjct: 572 DE----KANVSRAEATSEALEEACPQCGKPLFLRLGRHGRFVACSGYP-----ECNYTRP 622 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE 695 + + A R CP CG + Y + C P C E Sbjct: 623 V------------DGPREPAEPVGRDCPDCGKPLV-YKTGRYGRFISCSGYPECKHIEP- 668 Query: 696 EGEFRIKGYDGPIVECEKCG-SEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPK 752 + V C +CG E+ K R+GK + +C +C Sbjct: 669 -----LTQPKSSGVTCPQCGEGELVEKRSRYGKVFYSCNTYPKCTYAVWGPPVAR----- 718 Query: 753 EDPVPLPELPCEKSDAY-FVLRDGAA-GVFLAANTFPKS 789 PC + + + G G LA + Sbjct: 719 ---------PCPRCGWPIMIEKSGKRLGEQLACPQ-SEC 747 Score = 106 bits (264), Expect = 4e-21, Method: Composition-based stats. Identities = 30/151 (19%), Positives = 54/151 (35%), Gaps = 17/151 (11%) Query: 644 NVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKG 703 AE + + CP+CG + L + C P C+ +G Sbjct: 573 EKANVSRAEATSEALEEACPQCGKPLFLRL-GRHGRFVACSGYPECNYTRPVDGPRE--P 629 Query: 704 YDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 + +C CG + K GR+G++++C+ ECK+ + + + Sbjct: 630 AEPVGRDCPDCGKPLVYKTGRYGRFISCSGYPECKHIEPLTQ-----------PKSSGVT 678 Query: 763 CEKSD-AYFVLRDGAAGV-FLAANTFPKSRE 791 C + V + G F + NT+PK Sbjct: 679 CPQCGEGELVEKRSRYGKVFYSCNTYPKCTY 709 Score = 91.7 bits (226), Expect = 1e-16, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 46/132 (34%), Gaps = 22/132 (16%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C +CG + L++GR G+++AC+ EC TR + +P C Sbjct: 591 CPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVD-------GPREPAEPVGRDCPDCGKP 643 Query: 770 FVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMV 829 V + G G F++ + +P+ + + + + + Sbjct: 644 LVYKTGRYGRFISCSGYPECKHIEPLTQPKS--------------SGVTCPQCGEGELVE 689 Query: 830 RFSRKTKQQYVS 841 + SR K Y Sbjct: 690 KRSRYGKVFYSC 701 Score = 63.2 bits (152), Expect = 4e-08, Method: Composition-based stats. Identities = 14/93 (15%), Positives = 22/93 (23%), Gaps = 11/93 (11%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRF 803 E E C + LR G G F+A + +P+ TR Sbjct: 572 DEKANVSRAEATSEALEEACPQCGKPLFLRLGRHGRFVACSGYPECNYTRPVDGPREPAE 631 Query: 804 RDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 G + + R + Sbjct: 632 PVGRD-----------CPDCGKPLVYKTGRYGR 653 >UniRef50_A5D2W4 DNA topoisomerase n=4 Tax=Clostridiales RepID=A5D2W4_PELTS Length = 714 Score = 706 bits (1821), Expect = 0.0, Method: Composition-based stats. Identities = 295/778 (37%), Positives = 425/778 (54%), Gaps = 83/778 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI+K+LG + VK+S+GH+RDLP S Sbjct: 1 MSKTLVIVESPAKAKTISKFLGKKFTVKASMGHVRDLPKSQF------------------ 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 GVD + ++ Y + GK ++ +L+ +KAD + +A+D DREGEAIA Sbjct: 43 -----------GVDVKNGFKPKYITIRGKGDIIKDLRAAVKKADQVLIASDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+ ++ D+ R+ FNEITK AI++A P ++ +RVNAQQARR +DR+VGY +S Sbjct: 92 WHLQNLLEIDENESCRIEFNEITKQAIQKALQHPRPIDRNRVNAQQARRILDRLVGYNLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLW+KI +GLSAGRVQSVAVRL+ +RE EI++FVPEE+W + AS ++ Sbjct: 152 PLLWRKIKKGLSAGRVQSVAVRLICDREEEIQSFVPEEYWTLVASFVKTGEAPFEGRLIK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 D+ +KE+ Q + L+ ARY+V + K + KP PFITSTLQQ A +L F Sbjct: 212 FRDEKIDIPSKEKMQEVLENLKGARYTVEKVTRKEKSRKPPLPFITSTLQQEAYRKLNFT 271 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 +KTMM+AQ+LYE G ITY+RTDST +S A + YI + FG +Y Sbjct: 272 ARKTMMVAQQLYEGLDLGREGTSGLITYIRTDSTRVSASAREEAQKYIVERFGARYAGRE 331 Query: 352 PNQY---ASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 K Q+AHEAIRP+ V E +K+ + D KLY+LIW +F+A QM PA Sbjct: 332 TPPVGPAGRKGKIQDAHEAIRPTSVQREPEQVKEYLTGDQYKLYKLIWSRFLASQMKPAV 391 Query: 408 YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG---DEDRILPAVNKGDALTLVEL 464 +D+T + + AG++ +A G +++F G+ KV R +E+++LP + +G+ + L Sbjct: 392 FDTTNIDIKAGEYLFRANGSVMKFPGFMKVYTESRDDEEKEEEKLLPELKEGEEIEARSL 451 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 TP QHFT+PP R+++ASLV+ LE++GIGRPSTYA I+ TI RGYV EN++F+ ++G Sbjct: 452 TPRQHFTQPPPRYTDASLVRALEEKGIGRPSTYAPIVETILKRGYVVRENKQFFPTELGM 511 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 IV D L+++F+E+++ DFTA ME SLD + E +W VL+ F+ F L+KA E Sbjct: 512 IVVDLLKKHFKEIIDIDFTAGMEESLDSIEEGELDWIKVLESFYGPFKNTLEKA---ENE 568 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 G +T C CGR M ++ G FL C G+ C++T L+ Sbjct: 569 IGHVQVAEEVTEEKCDRCGRSMVVKVGRYGKFLACPGFP-----ECRSTKPLLEP----- 618 Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 +CP+C + RK C N P C+ Sbjct: 619 -------------VGAKCPRCEGELVVRRTKKGRKFLGCSNFPECEFVTW---------D 656 Query: 705 DGPIVECEKCGSEMHLKM--GRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPE 760 +C +CG M K G+ G ++ C +E+C + + E Sbjct: 657 QPSGTKCPECGGLMVEKKNAGKKG-FLQCVSEDCGYKKTAGEKKAGKKNADTESMSAE 713 Score = 72.8 bits (177), Expect = 6e-11, Method: Composition-based stats. Identities = 31/148 (20%), Positives = 58/148 (39%), Gaps = 25/148 (16%) Query: 704 YDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 + +C++CG M +K+GR+GK++AC EC++T+ +L Sbjct: 576 EEVTEEKCDRCGRSMVVKVGRYGKFLACPGFPECRSTKPLLE-------------PVGAK 622 Query: 763 CEKSDAYFVLRDGAAG-VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQD 821 C + + V+R G FL + FP+ V + PE + + + Sbjct: 623 CPRCEGELVVRRTKKGRKFLGCSNFPECEF-----VTWDQPSGTKCPECGGLMVE---KK 674 Query: 822 PEGNKTMVRF--SRKTKQQYVSSEKDGK 847 G K ++ ++ +K GK Sbjct: 675 NAGKKGFLQCVSEDCGYKKTAGEKKAGK 702 Score = 55.9 bits (133), Expect = 6e-06, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 35/98 (35%), Gaps = 20/98 (20%) Query: 756 VPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLA 815 + E C++ V++ G G FLA FP+ R T+ L Sbjct: 576 EEVTEEKCDRCGRSMVVKVGRYGKFLACPGFPECRSTKP------------------LLE 617 Query: 816 DAPQQDPEG-NKTMVRFSRKTKQQYVSSE-KDGKATGW 851 + P + +VR ++K ++ S + + W Sbjct: 618 PVGAKCPRCEGELVVRRTKKGRKFLGCSNFPECEFVTW 655 >UniRef50_B9L0B0 DNA topoisomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=B9L0B0_THERP Length = 744 Score = 706 bits (1821), Expect = 0.0, Method: Composition-based stats. Identities = 290/772 (37%), Positives = 418/772 (54%), Gaps = 95/772 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ALVIVESPAKA+TI ++LG Y VK+S+GH+RDLP Sbjct: 34 GQALVIVESPAKARTIARFLGPGYTVKASMGHVRDLP----------------------- 70 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +++GVD N++ Y VL K VV EL++ ++A + LATD DREGEAIAW Sbjct: 71 ------KSKLGVDVAQNFQPTYTVLKEKLPVVKELQESVQRARELILATDPDREGEAIAW 124 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL E D R+VF+EIT+ AIR+A P +++ VNAQQARR +DR+VGY +SP Sbjct: 125 HLIEATRAHDKPVRRIVFHEITEEAIREALAHPRGIDMRLVNAQQARRVLDRLVGYEISP 184 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST-TTPSGE----ALAL 236 LLW+K+ GLSAGRVQSVA+RLVV+REREI+AFVP+E+W ++ T +G A Sbjct: 185 LLWRKVKSGLSAGRVQSVALRLVVDREREIQAFVPQEYWTIEVDLVPTGNGAQEPVPFAA 244 Query: 237 QVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 + + N+E +A LE ++Y V+ +++ +P PFITSTLQQ A + Sbjct: 245 ALVRVRGEKPDLPNEEAARAVARELEASQYWVVSIKERQKQRRPAPPFITSTLQQEAGRK 304 Query: 297 LGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 L F V TM +AQ+LYE G ITYMRTDST ++ A R I+ +G + Sbjct: 305 LRFPVSLTMQLAQQLYEGVELGPEGSVGLITYMRTDSTQVAASAQQRAREVIAARWGADF 364 Query: 348 LPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTP 405 LPE P YA K + +QEAHEAIRP+D ES++ + +LY+LIW +F+A QM P Sbjct: 365 LPERPPVYAKKAKGAQEAHEAIRPTDPARDPESVRPYLTPRQYQLYRLIWERFIASQMAP 424 Query: 406 AKYDSTTLTVGAG-------DFRLKARGRILRFDGWTKVM-----PALRKGDEDRILPAV 453 A YD+ T+ + AG + L+A G ++RF G+ V + R LP + Sbjct: 425 AIYDTVTVEIAAGPTVGADAPYLLRATGSVVRFPGFLVVYREERDEDEVDELDQRPLPPL 484 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513 G+ L L+ + P QHFT+PP R+SEA+LVK LE+ GIGRPSTYA I T++ R YV VE Sbjct: 485 ATGEVLRLLAVRPEQHFTQPPPRYSEATLVKTLEELGIGRPSTYAPTIETLKQRRYVVVE 544 Query: 514 NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ 573 +R+ ++G +VTD L ++F ++++ FT+++E LD++A E +W V+ F+ F + Sbjct: 545 DRKLVPTELGMLVTDLLVQHFPDVVDVGFTSRLEEELDEIAAGERDWVPVVREFYEPFHR 604 Query: 574 QLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTT 633 Q+++AE+ E + + C CGR M I+ + G FL CSG+ CK Sbjct: 605 QVEEAEQTMERVRLADQ---PSGEVCELCGRPMVIKESRFGRFLSCSGFP-----ECKNK 656 Query: 634 INLVPENEVLNVLEGEDAETNALRAKRRCPKCGT-AMDSYLIDPKRKLHVCGNNPTCDGY 692 L+ + RCP+CG + R + C P CD Sbjct: 657 RPLL------------------EKIGVRCPQCGEGEIVVRRSRKGRTFYGCSRYPDCDFV 698 Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILR 744 C +CG + + + R + + C++ C + Sbjct: 699 SW---------ERPTGERCPQCGGVLVVSVRRGQESVRCSS--CSYRPAEEK 739 Score = 69.4 bits (168), Expect = 6e-10, Method: Composition-based stats. Identities = 20/132 (15%), Positives = 35/132 (26%), Gaps = 26/132 (19%) Query: 658 AKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCG-S 716 + C CG M R C P C + V C +CG Sbjct: 623 SGEVCELCGRPMVIKESRFGR-FLSCSGFPECKNKRPL--------LEKIGVRCPQCGEG 673 Query: 717 EMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRD 774 E+ ++ R G+ + C+ +C G C + V+ Sbjct: 674 EIVVRRSRKGRTFYGCSRYPDCDFVSWERPTG--------------ERCPQCGGVLVVSV 719 Query: 775 GAAGVFLAANTF 786 + ++ Sbjct: 720 RRGQESVRCSSC 731 Score = 65.5 bits (158), Expect = 1e-08, Method: Composition-based stats. Identities = 22/115 (19%), Positives = 37/115 (32%), Gaps = 17/115 (14%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 R++ + CE V+++ G FL+ + FP+ + R L Sbjct: 602 FHRQVEEAEQTMERVRLADQPSGEVCELCGRPMVIKESRFGRFLSCSGFPECKNKRPLL- 660 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE-KDGKATGW 851 + R P+ + +VR SRK + Y S D W Sbjct: 661 ---EKIGVRCPQCGE------------GEIVVRRSRKGRTFYGCSRYPDCDFVSW 700 >UniRef50_D1U7W1 DNA topoisomerase n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7W1_9DELT Length = 821 Score = 702 bits (1811), Expect = 0.0, Method: Composition-based stats. Identities = 297/853 (34%), Positives = 427/853 (50%), Gaps = 91/853 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAK KTI+K+LG DY+V +SVGH+RDLPT Sbjct: 1 MPKDLIIVESPAKVKTISKFLGKDYMVDASVGHVRDLPTRD------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD + + YE++ GKE+VV LK A+KA +YLA D DREGEAIA Sbjct: 42 ----------LGVDEENGFTPRYEIIQGKEEVVKRLKAAAKKAGTVYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ E++ ++ R+ FNEIT A+++A +LN + ++QQARR +DR+VGY +S Sbjct: 92 WHVAELLRPVNSNIRRIQFNEITARAVKEALENAQDLNQNLFDSQQARRILDRLVGYKIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWK + RG+SAGRVQSVA++L+VERE+E +AF +E+W + L++ Sbjct: 152 PILWKNVKRGISAGRVQSVALKLLVEREKERRAFKTDEYWPFKVLLEGGNPPPFWLELHK 211 Query: 241 QNDKPFR-----PVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 + K + + + +A LE +++V ++K P P+ITSTLQQ A+ Sbjct: 212 LSGKAVKPGVNHISTQAEAEALQQTLEAGQFTVDSVQEKQRKRDPLPPYITSTLQQDANR 271 Query: 296 RLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 R+G+ K+TM +AQRLYE ITYMRTDS ++++A R I D FG Sbjct: 272 RMGYSAKRTMSVAQRLYEGVELGRHGTTALITYMRTDSVRIAKEAQEAARELIIDRFGAD 331 Query: 347 YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTP 405 Y P P + +K +Q+AHEAIRP DV + + +K + ++ KLY+LIW++FVA QM Sbjct: 332 YYPSKPRNFKTKGGAQDAHEAIRPVDVTITPDDVKSSLPSEQHKLYRLIWQRFVASQMAA 391 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELT 465 A + TT+ V A +A+G L F G+ M + + LP + +G+ L L EL Sbjct: 392 ASFWDTTVLVSAPATEWRAKGERLLFPGFLAAMDKSG-TEAETELPKLVEGETLRLNELK 450 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 Q FT+PP R+SEASLVK LE+ GIGRPSTYA+IIST+ DR Y R E +RF ++G Sbjct: 451 KEQKFTQPPPRYSEASLVKTLEELGIGRPSTYAAIISTLLDREYARQEEKRFVPTELGFT 510 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 V+D+L E+F LM+ FTAQME+ LD VA + +W +L F DF L+KA + Sbjct: 511 VSDQLSEHFHALMDVGFTAQMESLLDDVAAGKQDWAKLLKDFGHDFYPTLEKARTEMARS 570 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 T I C CG+ M I+ TG FLGC+G+ C+T N + Sbjct: 571 QQE------TDIVCENCGKPMSIKFGKTGEFLGCTGFPT-----CRTIKNFTRDENGAIR 619 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYD 705 + C KCG M + C P C + + Sbjct: 620 I---VERETPEETGVECEKCGKPMAIKQSRRG-EFLGCTGYPDCKNIVNFQRDENGAISV 675 Query: 706 GPIVE------CEKCGSEMHLKMGRFG-KYMACTN-EECKNTRKILRNGEVAPPKEDPVP 757 + C CG E+ LK R G +++AC+N +C Sbjct: 676 IESEKLQVVGSCPDCGGELLLKKARTGSRFIACSNYPDCTYAAPF--------------- 720 Query: 758 LPELPCEK--SDAYFVLRDGAAGV-FLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYL 814 +PC V + G F + + +PK + P+ + Sbjct: 721 STGVPCPVEGCAGELVEKSSRRGKIFFSCSAYPKCDYAVWNWP-----VNEPCPKCGHPI 775 Query: 815 ADAPQQDPEGNKT 827 +G Sbjct: 776 LTRKTTKDKGEHL 788 >UniRef50_Q3A7H8 DNA topoisomerase n=13 Tax=Bacteria RepID=Q3A7H8_PELCD Length = 841 Score = 700 bits (1806), Expect = 0.0, Method: Composition-based stats. Identities = 301/828 (36%), Positives = 427/828 (51%), Gaps = 99/828 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M ++LVIVESPAKAKTI K+LG Y V +S GH+R LP+ Sbjct: 1 MAQSLVIVESPAKAKTIEKFLGPGYKVLASYGHVRALPSKQG------------------ 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VD HN+ Y VLP +K + LK+ A+K+ + LATD DREGEAIA Sbjct: 43 -----------SVDVEHNFSPLYHVLPESQKHIELLKKEAKKSRELILATDPDREGEAIA 91 Query: 121 WHLREVIGGDD----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WHL E +G D+ RV F+EITK AI++A +KPG + + V+AQQAR +D +VG Sbjct: 92 WHLLEALGIDENAKSPEVKRVTFHEITKGAIQEAISKPGHIARELVDAQQARSILDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 + +SP LWKKI GLSAGRVQSVA+RL+ ERE+EI+AF E+W ++ T G Sbjct: 152 FNLSPFLWKKIRYGLSAGRVQSVALRLICEREKEIQAFEAREYWTIETRLATEQGSVFPA 211 Query: 237 QVTHQNDK---PFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAA 293 ++ + F + Q V + + V + + P APF TSTLQQ A Sbjct: 212 RLYAVDGNSLGKFDINQEAQALELVKAIGSEAFQVEKLKKTSKKRNPAAPFTTSTLQQEA 271 Query: 294 STRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 S +LGF +KTM +AQ+LYE G ITYMRTDS LSQ A R I+ +G+ Sbjct: 272 SRKLGFSARKTMTVAQKLYEGIDVGNGLEGLITYMRTDSVALSQVATGEARELITRMYGE 331 Query: 346 KYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQM 403 Y + P + +K +N+QEAHEA+RP+ ++ + + +K + +D KLY+LIW++ VA QM Sbjct: 332 DYALDKPRVFKNKAKNAQEAHEAVRPTSLSNLPDQIKAHLSSDQFKLYRLIWQRTVASQM 391 Query: 404 TPAKYDSTTLTVGAGD-FRLKARGRILRFDGWTKVMPALRKGDEDR------ILPAVNKG 456 A+ ++TT+ + AG+ F +A G+++RF G+ K+ DED+ LP + + Sbjct: 392 ATAQLEATTVDIRAGERFVFRASGQVVRFPGFMKLYIEDTDKDEDQDRQEEGTLPPLEQE 451 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 L E+ P+QHFT+PP RF+EASLVK LE+ GIGRPSTYASII+T+ R YVR+E R Sbjct: 452 QPLDCQEVQPSQHFTQPPPRFTEASLVKTLEEHGIGRPSTYASIINTLTTRKYVRLEKRA 511 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 FY E +G +V D L +F + ++YDFTAQ+E LD ++ E EW+ VL F+ F + Sbjct: 512 FYTEDVGMVVNDLLVNHFNKYVDYDFTAQLEEDLDAISRGEREWQPVLKDFWEPF---IS 568 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 + ++ + + T CP CG+ + I+ +G FL CSG+ C+ T L Sbjct: 569 RLKEKETQISKQDVTTEKTDRICPECGKPLVIKLGRSGRFLACSGFP-----DCRYTEPL 623 Query: 637 VPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEE 696 + V+ + + C KCG M K C P C + Sbjct: 624 AGQEREEPVM-----------SDQTCEKCGAPMLIKQ-GRYGKFLACSAYPECKNIQP-- 669 Query: 697 GEFRIKGYDGPIVECEKCG-SEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKE 753 + + C +CG E+ K R+GK + +C +CK L Sbjct: 670 ----LVKPKALGITCPQCGEGELMEKKSRYGKIFYSCNRYPKCKYALWDLP--------- 716 Query: 754 DPVPLPELPCEKSDAYFVLRDG--AAGVFLAANTFPKSRETRAPLVEE 799 E PC K V+ G F T + E Sbjct: 717 -----IEEPCPKCKFPLVVEKTTKRQGTFRKCPQ-EDCDWTVVLIPPE 758 Score = 66.7 bits (161), Expect = 4e-09, Method: Composition-based stats. Identities = 15/99 (15%), Positives = 31/99 (31%), Gaps = 10/99 (10%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 ++ ++ + C + V++ G +G FLA + FP R T Sbjct: 566 FISRLKEKETQISKQDVTTEKTDRICPECGKPLVIKLGRSGRFLACSGFPDCRYTEPLAG 625 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 +E + + G +++ R K Sbjct: 626 QEREEP----------VMSDQTCEKCGAPMLIKQGRYGK 654 >UniRef50_C6BUQ9 DNA topoisomerase n=14 Tax=Desulfovibrionales RepID=C6BUQ9_DESAD Length = 800 Score = 699 bits (1805), Expect = 0.0, Method: Composition-based stats. Identities = 303/868 (34%), Positives = 460/868 (52%), Gaps = 100/868 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L++VESPAK KTI+K+LG +Y V +SVGH+RDLP Sbjct: 1 MSKDLIVVESPAKVKTISKFLGRNYQVAASVGHVRDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 N++GV+ ++ Y+V+PGKE VV++LK+ A KADH++LA D DREGEAI Sbjct: 39 -------KNKLGVEENGDFTPQYQVIPGKEDVVNKLKKAAAKADHVFLAPDPDREGEAIG 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ +I + SR+ FNEIT A+++A P LN ++QQARR +DR+VGY +S Sbjct: 92 WHVAAIIKEVNENVSRIQFNEITARAVKEALEHPQPLNEQLFDSQQARRILDRLVGYKIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ RG+SAGRVQSVA++LVVERE+ +AF+PEE+W A + + Sbjct: 152 PILWKKVKRGISAGRVQSVALKLVVEREKARRAFIPEEYWLFKAHVEGKNPPPFIADLWK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + K + ++ +A S ++ + + + +K P P+ITSTLQQ A+ RLG+ Sbjct: 212 VDGKKAEIGSADEAEALQSNVKGVPFEITDLTEKERKRNPLPPYITSTLQQDANRRLGYS 271 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 K+TM +AQRLYE ITYMRTDS ++ +A + + I D +G ++ P Sbjct: 272 AKRTMTLAQRLYEGVELGDKGTTALITYMRTDSVRIANEARDTAKKVILDKYGDEFYPAK 331 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 P Y SK +Q+AHEAIRP D +++ E +K + AD K+Y+LIW +F+A QM PA++ Sbjct: 332 PQVYKSKGGAQDAHEAIRPVDASILPEDVKPYLPADQFKVYKLIWNRFIASQMAPARFWD 391 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 T +T+ A + +++G L F G+ +V ++ LP + KG+ L + ++ Q F Sbjct: 392 TVVTIQAKNTIWRSKGERLLFPGFMRVTGKTG-DEKLIELPKLEKGEVLKVDKIESEQKF 450 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PPAR+SEASLV+ELE++GIGRPSTYASIISTIQDRGYV +E ++F ++G +V+D+L Sbjct: 451 TQPPARYSEASLVRELEEKGIGRPSTYASIISTIQDRGYVNLEEKKFIPTELGFVVSDQL 510 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 E+F+ELM+ FTA ME LD VA+ + EW +++ F F L+ A K+ + GG Sbjct: 511 SEHFKELMDVGFTAAMEKQLDDVADGKIEWTSLMKDFVDGFYPTLETAAKEMKRGG---- 566 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 T I C C M I+ TG FLGCS Y CK +N + + V+ Sbjct: 567 --EDTGITCDKCESPMVIKFGRTGEFLGCSNYP-----ECKNIVNFTRDEKGKIVV---L 616 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFR------IKGY 704 E C KCG+AM + + C P C + E + Sbjct: 617 EEEPPEETGVTCEKCGSAMAIKRSNRG-EFLGCTGYPDCRNIKNFERDDEGKIKVVETPT 675 Query: 705 DGPIVECEKC-GSEMHLKMGRFG-KYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPEL 761 + +C C ++ +K R G +++AC+N +CK+ + + Sbjct: 676 AQIVGKCPDCDDGDLIIKHARTGSRFIACSNYPDCKHAKPF---------------STGV 720 Query: 762 PCEK--SDAYFVLRDGAAGV-FLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAP 818 C + V + G F + + +P + Y Sbjct: 721 KCPREGCKGELVEKSSRRGKLFYSCDQYPDCDY------------------AVWYPPIDG 762 Query: 819 QQDPEGNKTMVRFSRKTKQQYVSSEKDG 846 G+ +V+ + + K ++++ + G Sbjct: 763 PCPKCGHPVLVKKTTRAKGEHIACPEKG 790 >UniRef50_B0MRI8 DNA topoisomerase n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MRI8_9FIRM Length = 713 Score = 698 bits (1802), Expect = 0.0, Method: Composition-based stats. Identities = 298/756 (39%), Positives = 418/756 (55%), Gaps = 76/756 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKAKTI KYLG DY V +SVGHIRDLP Sbjct: 18 LVIVESPAKAKTIEKYLGKDYSVVASVGHIRDLP-------------------------- 51 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +++GVD +N+E YE K ++ ELK+ A+ +D +YLATD DREGEAI+WHL Sbjct: 52 ---KSKLGVDVDNNFEPKYENKKDKAALIKELKKDAKASDIVYLATDPDREGEAISWHLA 108 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 V+G RV F+EITK+ I + P L++D +NAQQARR +DR+VGY +SP LW Sbjct: 109 HVLGISPDAPVRVTFSEITKSGIEAGMSHPRTLDMDLINAQQARRILDRIVGYKLSPFLW 168 Query: 185 KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS-TTTPSGEALALQVTHQND 243 KK+ RGLSAGRVQSVAVRL+V+RE+EI++F +E+W +DA + S A ++T Sbjct: 169 KKVRRGLSAGRVQSVAVRLIVDREQEIESFEAQEYWSIDAKLLSASSRRAFPAKLTEVKG 228 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 + F+ +NKE+T +++LE + + ++ P PF TSTLQQ AS +L F ++ Sbjct: 229 EKFKALNKEETDKVLAMLENGEFIITNIKNSTRKKTPAPPFTTSTLQQEASRKLSFNARR 288 Query: 304 TMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 TM AQ LYE G ITYMRTDS +S +A I +GK+YLP P Sbjct: 289 TMKAAQELYEGVEIPDMGAVGIITYMRTDSLRISDEAKAAAAQMIESTYGKEYLPSKPRV 348 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 + SK N+Q+AHEAIRP+ + + E +K + D KLY+LIW +F+A QM D+ + Sbjct: 349 FKSKNNAQDAHEAIRPTIITLTPEKVKSALSGDQYKLYKLIWERFMASQMENQLLDTKAV 408 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR--ILPAVNKGDALTLVELTPAQHFT 471 + G+ KA G ++FDG+TK+ + DE+ LPA+ G+ L + ELT QHFT Sbjct: 409 DITCGECLFKANGYTVKFDGFTKLYEESKDNDEEEGGALPALEVGEKLKVKELTGNQHFT 468 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 +PP R++EASL+K LE+ GIGRPSTYA I+TI DR YV E ++ +G ++TD ++ Sbjct: 469 QPPPRYTEASLIKALEENGIGRPSTYAPTIATILDRHYVEREAKQLKPTSLGIVITDLMK 528 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 +F +++ FTAQME+ LD++ +A+W VL F++ F + L KAEKD E ++ Sbjct: 529 GHFERIVDAKFTAQMESDLDKIEAGKADWVDVLGKFYTGFDKMLTKAEKDMEGKRVKI-P 587 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 T I C CG+ M I+ G FLGCSG+ CK T +V Sbjct: 588 DEPTDIVCDKCGKPMVIKIGPYGKFLGCSGFP-----ECKNTKRIV-------------- 628 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVEC 711 CP CG M + + C N C+ +C Sbjct: 629 ----NETGGLCPHCGGKMLAKKSKKGKPFFGCENYKDCNFMTW---------DTPLEDKC 675 Query: 712 EKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGE 747 KCGS + K+G+ G+ + C + C R + + Sbjct: 676 PKCGSTLFKKVGKQGQ-VYCAKDGCGYVRPADEDKK 710 Score = 67.1 bits (162), Expect = 3e-09, Method: Composition-based stats. Identities = 59/493 (11%), Positives = 134/493 (27%), Gaps = 107/493 (21%) Query: 422 LKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEAS 481 A+ ++ + + + K + D++L + G+ + + + + P F+ ++ Sbjct: 219 FPAKLTEVKGEKFKAL----NKEETDKVLAMLENGEFI-ITNIKNSTRKKTPAPPFTTST 273 Query: 482 L---------------------------VKELEKRGIGR-------------PSTYASII 501 L + ++ GI + A +I Sbjct: 274 LQQEASRKLSFNARRTMKAAQELYEGVEIPDMGAVGIITYMRTDSLRISDEAKAAAAQMI 333 Query: 502 STIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWK 561 + + Y+ + R F ++ + + + L + + ++ + W+ Sbjct: 334 ESTYGKEYLPSKPRVFKSKNNAQDAHEAIRPTIITLTPEKVKSALSGDQYKLY--KLIWE 391 Query: 562 AVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG 621 + NQ++ T TCG + T F G + Sbjct: 392 RFMASQME--------------------NQLLDTKAVDITCGECLFKANGYTVKFDGFTK 431 Query: 622 YALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK---- 677 K+ + +P EV L+ ++ N + ++ L + Sbjct: 432 LYEESKDNDEEEGGALPALEVGEKLKVKELTGNQHFTQPPPRYTEASLIKALEENGIGRP 491 Query: 678 RKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEEC- 736 Y E + G ++ G + +F M ++ Sbjct: 492 STYAPTIATILDRHYVEREAKQLKPTSLGIVITDLMKGHFERIVDAKFTAQMESDLDKIE 551 Query: 737 -----------------KNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGV 779 + P ++ C+K V++ G G Sbjct: 552 AGKADWVDVLGKFYTGFDKMLTKAEKDMEGKRVKIPDEPTDIVCDKCGKPMVIKIGPYGK 611 Query: 780 FLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQY 839 FL + FP+ + T+ + E G K + + S+K K + Sbjct: 612 FLGCSGFPECKNTKRIVNETGGLCPH-----------------CGGKMLAKKSKKGKPFF 654 Query: 840 VSSE-KDGKATGW 851 KD W Sbjct: 655 GCENYKDCNFMTW 667 >UniRef50_D1C7I9 DNA topoisomerase n=8 Tax=Bacteria RepID=D1C7I9_SPHTD Length = 769 Score = 698 bits (1802), Expect = 0.0, Method: Composition-based stats. Identities = 286/768 (37%), Positives = 408/768 (53%), Gaps = 99/768 (12%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LVIVESPAKA+ I + LG Y VK+S+GH+RDLP Sbjct: 61 TLVIVESPAKARNIGRILGRGYTVKASMGHVRDLP------------------------- 95 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +++GV+ ++ Y + K KVV EL+ ++A I LATD DREGEAIAWHL Sbjct: 96 ----KSKLGVETDRDFAPVYLIPRDKSKVVKELRADVKEAREILLATDPDREGEAIAWHL 151 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 E D R+VF+EIT AIR+A P +++ V AQQARR +DR+VGY +SPLL Sbjct: 152 VEATDPGDKPVRRIVFHEITPEAIREALRNPRGIDMRLVEAQQARRILDRLVGYEISPLL 211 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG------EALALQ 237 W+K+ RGLSAGRVQSVA+RLVVEREREI+ FVP+E+W +DA + Sbjct: 212 WRKVKRGLSAGRVQSVALRLVVEREREIQNFVPQEYWTLDAELAKREAVNGRKPKPFVAS 271 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 ++ N + ++ T A V L+ A + V++ E K T +P PF TSTLQQ AS +L Sbjct: 272 LSRVNGQKPDLKDEASTMAIVRALDGAEFQVVKVEVKETQRRPAPPFTTSTLQQEASRKL 331 Query: 298 GFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 V++TM +AQ LYE G ITYMRTDSTN++ A R I++ +G ++L Sbjct: 332 NMPVRRTMQIAQELYEGIDLGDAGTVGLITYMRTDSTNVAASAQARAREVIAERYGPEFL 391 Query: 349 PESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDM----EADAQKLYQLIWRQFVACQM 403 P+ P Y K + +QEAHEAIRP+D ES+K + KLY+LIW++F+A Q Sbjct: 392 PDRPPVYTRKAKGAQEAHEAIRPTDPARDPESIKAFLGGASSPRYKLYRLIWQRFIASQT 451 Query: 404 TPAKYDSTTLTVGAG------DFRLKARGRILRFDGWTKVMPALRKGD-----EDRILPA 452 A +DST + + AG +R +A G +++F G+ + R D + LP Sbjct: 452 RNAVFDSTAVDIDAGPPGGPKPYRFRATGSVIKFPGFLAIYREGRDDDTVDEIDREALPP 511 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 + +G+ L LV L P QHFT+PP RF+EA+LVK LE+ GIGRPSTYA I+T+Q R YV V Sbjct: 512 LTEGEVLDLVRLLPEQHFTQPPPRFTEATLVKALEELGIGRPSTYAPTIATLQARNYVTV 571 Query: 513 ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 E RR Y ++G +V D L ++F ++++ +FT+++E+ LDQ+A+ E W ++ F+ F Sbjct: 572 EQRRLYPTELGTVVNDLLVQHFPDIVDVNFTSKLEDELDQIASGEQSWVPMVRAFYGPFH 631 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKT 632 + +++AEK+ G T C CGR M I+ G FL CSG+ C+ Sbjct: 632 ETVERAEKEI---GRVKVADEPTDEVCEKCGRPMVIKLGRYGRFLACSGFP-----ECRN 683 Query: 633 TINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA-MDSYLIDPKRKLHVCGNNPTCDG 691 L+ + CP+CG + R + C P C+ Sbjct: 684 ARPLLQ------------------KIGVTCPQCGEGDIVQRRTKKGRVFYGCSRYPDCNF 725 Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNT 739 C +CG + G + C+ + C+ Sbjct: 726 SSW---------EKPTGEPCPQCGGVLVETR---GGTVRCSTQGCQYR 761 Score = 67.4 bits (163), Expect = 2e-09, Method: Composition-based stats. Identities = 23/137 (16%), Positives = 37/137 (27%), Gaps = 29/137 (21%) Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVEC 711 + C KCG M L R C P C V C Sbjct: 645 KVADEPTDEVCEKCGRPMVIKLGRYGR-FLACSGFPECRNARPL--------LQKIGVTC 695 Query: 712 EKCG-SEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA 768 +CG ++ + + G+ + C+ +C + G PC + Sbjct: 696 PQCGEGDIVQRRTKKGRVFYGCSRYPDCNFSSWEKPTG--------------EPCPQCGG 741 Query: 769 YFVLRDGAAGVFLAANT 785 V G + +T Sbjct: 742 VLVE---TRGGTVRCST 755 Score = 62.4 bits (150), Expect = 7e-08, Method: Composition-based stats. Identities = 25/113 (22%), Positives = 39/113 (34%), Gaps = 9/113 (7%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 + R + + + CEK V++ G G FLA + FP+ R R L Sbjct: 630 FHETVERAEKEIGRVKVADEPTDEVCEKCGRPMVIKLGRYGRFLACSGFPECRNARPLL- 688 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATG 850 + P+ D Q+ + + SR + S E K TG Sbjct: 689 ---QKIGVTCPQCGE--GDIVQRRTKKGRVFYGCSRYPDCNFSSWE---KPTG 733 >UniRef50_C9LSJ2 DNA topoisomerase n=3 Tax=Veillonellaceae RepID=C9LSJ2_9FIRM Length = 836 Score = 698 bits (1800), Expect = 0.0, Method: Composition-based stats. Identities = 304/765 (39%), Positives = 437/765 (57%), Gaps = 77/765 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 + LV+VESPAKAKTI KYLG Y+V++S+GH+RDLP S Sbjct: 115 PQTLVVVESPAKAKTIEKYLGKKYMVRASMGHLRDLPKSQF------------------- 155 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 G+D +++ Y + GK ++ LK+ A+ A +YLA+D DREGEAIAW Sbjct: 156 ----------GIDVENDFAPKYINIRGKGDLIKALKKDAKHAAKVYLASDPDREGEAIAW 205 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL ++G D R+VFNEITK AI+ A +P +N+DRV+AQQARR +DR+VGY +SP Sbjct: 206 HLAHILGIDPNENCRIVFNEITKPAIQAAVKEPYPINLDRVDAQQARRMLDRIVGYKLSP 265 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLW+KI +GLSAGRVQSV V+L+ +RE+EI+AFVPEE+W V G A ++ Sbjct: 266 LLWRKIKKGLSAGRVQSVTVKLICDREKEIQAFVPEEYWTVGMKLKKGRGAQFAAELATV 325 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + K +KE+T A V + K +SV E + + P APF TS++QQ AS +LGF Sbjct: 326 DGKKLALHSKEETSALVKDMAKQSFSVKEVKKRERRRNPVAPFTTSSMQQDASRKLGFTS 385 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 ++TMM+AQ+LYE G ITYMRTDST LS A++ VRGY+ +FG YLPE P Sbjct: 386 RRTMMIAQQLYEGVELGRRGPVGLITYMRTDSTRLSDLALDEVRGYVGTSFGADYLPEKP 445 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 N YA+ + +Q+AHEAIRP+ V E ++ + + +LY LIW++FVA QMTPA +D+ Sbjct: 446 NIYAAGKKAQDAHEAIRPTSVENTPELMEKYLSREQLRLYTLIWQRFVASQMTPAVFDTV 505 Query: 412 TLTVGAGD-FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 +++V AG+ + +A G L+F G+ V A K ++D +LP + G+AL+L++L P QHF Sbjct: 506 SVSVAAGERYIARASGSTLKFPGFLAVY-ADNKKEKDVLLPELAAGEALSLLDLLPEQHF 564 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP R++EASLVK LE+ IGRPSTYA II TI RGYV +++ F +G +V D L Sbjct: 565 TEPPPRYNEASLVKTLEEEDIGRPSTYAPIIETILARGYVVRQDKHFQPTDLGFLVNDML 624 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 EE+F+++++ FTA +EN LD++A + + +L F+ F + L++A E G Sbjct: 625 EEHFKDIVDVQFTAGLENELDEIAEGKVDKNDLLRGFYEPFEKTLEEA---DEAIGEVEI 681 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 ++ + C CGR M ++ G FL C G+ C+ T L+ + Sbjct: 682 PEEVSDVICEKCGRNMVVKQGRYGKFLACPGFP-----DCRNTKPLLKD----------- 725 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710 CPKCG + + + C N P CD + Sbjct: 726 -------TGVPCPKCGGRIVERRSRRGQAFYGCENYPACDYVTW---------DQPLTEK 769 Query: 711 CEKCGSEMHLKMGRFGKYM-ACTNEECKNTRKILRNGEVAPPKED 754 C +CG+ M + G+ + C+NEECK N E+ + Sbjct: 770 CPECGAFMLRHRYKNGRILPYCSNEECKTRIDHPINKEIEKSRAR 814 Score = 75.9 bits (185), Expect = 7e-12, Method: Composition-based stats. Identities = 29/114 (25%), Positives = 46/114 (40%), Gaps = 20/114 (17%) Query: 703 GYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPEL 761 + V CEKCG M +K GR+GK++AC +C+NT+ +L++ + Sbjct: 682 PEEVSDVICEKCGRNMVVKQGRYGKFLACPGFPDCRNTKPLLKD-------------TGV 728 Query: 762 PCEKSDAYFVLRDGAAGV-FLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYL 814 PC K V R G F +P V ++ PE ++ Sbjct: 729 PCPKCGGRIVERRSRRGQAFYGCENYPACDY-----VTWDQPLTEKCPECGAFM 777 Score = 59.3 bits (142), Expect = 6e-07, Method: Composition-based stats. Identities = 23/106 (21%), Positives = 36/106 (33%), Gaps = 17/106 (16%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 + + E E P + ++ CEK V++ G G FLA FP R T+ L Sbjct: 665 FEKTLEEADEAIGEVEIPEEVSDVICEKCGRNMVVKQGRYGKFLACPGFPDCRNTKPLLK 724 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 + P G + + R SR+ + Y Sbjct: 725 D----------------TGVPC-PKCGGRIVERRSRRGQAFYGCEN 753 >UniRef50_C6HWV0 DNA topoisomerase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HWV0_9BACT Length = 865 Score = 695 bits (1793), Expect = 0.0, Method: Composition-based stats. Identities = 295/878 (33%), Positives = 422/878 (48%), Gaps = 112/878 (12%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L++VESP KA+T+ + LG DY VK+SVGH++DLP Sbjct: 49 TLIVVESPTKARTLTRILGPDYRVKASVGHLKDLP------------------------- 83 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +R+GVD ++E +EV GK+KV+ E++Q A A IYLA+D DREGEAIA+H+ Sbjct: 84 ----ASRIGVDVDRDYELEFEVSEGKKKVLDEIRQAARGAREIYLASDPDREGEAIAYHI 139 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 + RV+ +E+T I QA PGE+++ +V+AQ+ARR +DR+VGY +SPLL Sbjct: 140 ASELSSLKKPIRRVLVHELTPRGIAQALEHPGEIDLHKVDAQKARRALDRIVGYSLSPLL 199 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT----TPSGEALALQVT 239 W+++ RGLSAGRVQSVAVRLV +RE EI AFVP E+W + + +A ++ Sbjct: 200 WERVRRGLSAGRVQSVAVRLVCDRENEINAFVPVEYWTILQTFHPTESGRETDAFEAKLD 259 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 + ++++ QA + L + + +P P TS LQQ + R F Sbjct: 260 RIAGEKAEIGSQQEAQAVLERLSGENFRIGSVSADEKKRQPSPPLTTSRLQQEGARRFRF 319 Query: 300 GVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 KKTM +AQ+LYE G ITYMRTDS L+ +A M R YI N+ + LP Sbjct: 320 PAKKTMQVAQKLYEGVEIPGQGLTGLITYMRTDSVRLAPEAQEMARDYIRRNYPQG-LPS 378 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 Y +K+ Q+AHEAIRP+DVN ESL ++ D ++YQLIW+ FV QM PA+Y Sbjct: 379 KSPSYRNKKGIQDAHEAIRPTDVNRTPESLASVLDRDLLRVYQLIWQSFVESQMLPARYL 438 Query: 410 STTLTVGAGDFR-LKARGRILRFDGWTKVMPALRKG---------------DEDRILPAV 453 TT+ V +A GR + G+ V A KG +E+ LP + Sbjct: 439 QTTVIVEGDQADSFRATGRRMLDPGFLAVRGARGKGAARSAKNEEEEDGTDEEEAELPLL 498 Query: 454 NKGD-ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 ++G+ + L +QHFT+PP R++EASL++ELE++GIGRPSTYA+I++TI DR YV Sbjct: 499 HEGESVVALGPPDASQHFTQPPPRYNEASLIRELEEKGIGRPSTYATIMTTILDREYVEK 558 Query: 513 ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 RFY ++G+ V L ++F +L+N FTA+ME LD V + ++ +D F+ F+ Sbjct: 559 RENRFYPTELGQTVNRLLVDSFPDLLNVAFTARMEEELDAVEEGDKVYREAVDDFYRPFS 618 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKT 632 +L +A+ T I CP CG M + G +L C Y CKT Sbjct: 619 AELGRAKGGGMTNLKAK--SEPTDIPCPVCGTLMVKKWGRHGAYLACGNYPA-----CKT 671 Query: 633 TINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGY 692 T N+V G E C CG M C + P C Sbjct: 672 TRNIVQTE------SGPAPEVLPEAPGEVCQTCGKPMIVRK-GRFGTFLACSDYPACKTT 724 Query: 693 EIEEGEFRIKGYDGP---IVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEV 748 + + + C CG M +K GRFG +++C N CK TR + Sbjct: 725 RPWPPKGQPSPPVPLPADLPPCPACGGAMVVKSGRFGSFLSCANYPACKTTRPLPTGIRC 784 Query: 749 APPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLP 808 D V R G GVF + +P+ T Sbjct: 785 TR-------------PGCDGEIVPRRGKRGVFYGCSRYPECDRTYPGRP----------- 820 Query: 809 EKLRYLADAPQQDPEGNKTMVRFSR-KTKQQYVSSEKD 845 + P + + K + V EKD Sbjct: 821 --------VARPCPSCGHAFLMEKKTGGKLRLVCPEKD 850 >UniRef50_Q1PYZ6 DNA topoisomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PYZ6_9BACT Length = 773 Score = 694 bits (1792), Expect = 0.0, Method: Composition-based stats. Identities = 319/816 (39%), Positives = 453/816 (55%), Gaps = 84/816 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 LVIVESPAKAKTI+K+L + + VKSS+GH+RDLP Sbjct: 5 KTNLVIVESPAKAKTISKFLDASFFVKSSMGHVRDLP----------------------- 41 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++ VD +++ Y+V+P +EK++ EL ++KA +YLA+DLDREGEAIAW Sbjct: 42 ------AKKLSVDIENDFTPEYKVIPSREKLIKELISDSKKASTVYLASDLDREGEAIAW 95 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL +V+ + RV FNEITK+AI++AF + G +N+++VNAQQARR +DR+VGY +SP Sbjct: 96 HLYKVLDIPPEKIRRVTFNEITKDAIQEAFKQYGPINMEKVNAQQARRILDRIVGYKISP 155 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-------EAL 234 LLWKKIA+ LSAGRVQSVAVRL+VERE+EI F P E+W++ A T SG + Sbjct: 156 LLWKKIAKRLSAGRVQSVAVRLIVEREKEINEFKPHEYWKITAELKTISGDKKSDDIKPF 215 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 + DK N++Q + L+ A + + + + + PF TS LQQ AS Sbjct: 216 KALLQKLEDKNIEIKNEQQAKEITEKLQNASFIITNIKKQTKRNNAPPPFTTSLLQQQAS 275 Query: 295 TRLGFGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 TRL F KKTM++AQ+LYE AG ITYMRTDS ++S A+ R +I N+GK Sbjct: 276 TRLQFSAKKTMLIAQQLYEGIDVGADGPAGLITYMRTDSFHVSDHALTSCRNFIESNYGK 335 Query: 346 KYLPESPNQY-ASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQM 403 YLPE PN Y ++K+ +Q AHEA+RP+ + ES+K + D KLY+LIW++FVA QM Sbjct: 336 DYLPEKPNIYASNKKGTQGAHEAVRPTYLEYTPESIKQFLTKDQHKLYELIWKRFVASQM 395 Query: 404 TPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVE 463 PA Y T + + + + K RGR L FDG T + E++ILP + K L L++ Sbjct: 396 KPALYAITDVEITSNRYIFKTRGRELLFDGHTLISGH-EVDREEQILPPLEKDHVLELIQ 454 Query: 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMG 523 L P QHFT+PP R+SEASLVK LEK GIGRPSTYA+IISTIQDRGYV+ E R FYA ++G Sbjct: 455 LLPTQHFTQPPPRYSEASLVKTLEKMGIGRPSTYATIISTIQDRGYVKQEKRAFYATELG 514 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPE 583 +VT++L E+F+++M+ +FT+ ME+ LD++ + +W VL F+ F L+KA + + Sbjct: 515 ILVTEKLIEHFQKIMDVNFTSHMEDELDKIEEKKIDWLTVLKEFYEPFKIDLEKAIGEMK 574 Query: 584 EGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVL 643 P + C C + M IR G F GCS + CK T+ L + E Sbjct: 575 SVKGTP---EESDRICNLCSKPMVIRWGRHGKFFGCSAFP-----ECKNTMPLDEKGEAA 626 Query: 644 NVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKG 703 + + C KCG+ M K C P C + Sbjct: 627 P----------PETSDQACEKCGSPMIIKTS-RHGKFMACSAYPNCKNTK--SLTGETTK 673 Query: 704 YDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 + +CEKCGS M ++ + G++M C+ +C+N + + + P Sbjct: 674 VEPTNEKCEKCGSPMVIRFSKKGRFMGCSGYPKCRNIKSLPTGI-------------KCP 720 Query: 763 CEKSDAYFVLRDGAA-GVFLAANTFPKSRETRAPLV 797 ++ + R G+F + +P L Sbjct: 721 RDECGGDLIQRYSKKGGIFFGCSKYPDCDYISKELP 756 Score = 91.3 bits (225), Expect = 1e-16, Method: Composition-based stats. Identities = 33/142 (23%), Positives = 58/142 (40%), Gaps = 17/142 (11%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKED 754 E + + C C M ++ GR GK+ C+ ECKNT + GE APP+ Sbjct: 572 EMKSVKGTPEESDRICNLCSKPMVIRWGRHGKFFGCSAFPECKNTMPLDEKGEAAPPETS 631 Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYL 814 CEK + +++ G F+A + +P + T++ E Sbjct: 632 DQA-----CEKCGSPMIIKTSRHGKFMACSAYPNCKNTKSLTGETTKVEPTNE------- 679 Query: 815 ADAPQQDPEGNKTMVRFSRKTK 836 + + G+ ++RFS+K + Sbjct: 680 ----KCEKCGSPMVIRFSKKGR 697 Score = 63.6 bits (153), Expect = 3e-08, Method: Composition-based stats. Identities = 15/99 (15%), Positives = 29/99 (29%), Gaps = 9/99 (9%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 + + + + C V+R G G F + FP+ + T Sbjct: 562 FKIDLEKAIGEMKSVKGTPEESDRICNLCSKPMVIRWGRHGKFFGCSAFPECKNTMPL-- 619 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 + PE + G+ +++ SR K Sbjct: 620 --DEKGEAAPPE-----TSDQACEKCGSPMIIKTSRHGK 651 >UniRef50_A3EPL6 DNA topoisomerase n=2 Tax=Leptospirillum sp. Group II RepID=A3EPL6_9BACT Length = 850 Score = 692 bits (1786), Expect = 0.0, Method: Composition-based stats. Identities = 302/824 (36%), Positives = 420/824 (50%), Gaps = 87/824 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L+IVESP KA+T++K LGS Y+VK+SVGH++DLP Sbjct: 49 GKTLIIVESPTKARTLSKVLGSGYLVKASVGHVKDLP----------------------- 85 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +R+G+D H++ +EV P K+KV+SE++ A A +YLA+D DREGEAIA+ Sbjct: 86 ------PSRLGIDVDHDFALEFEVHPDKKKVLSEIRSEARSAREVYLASDPDREGEAIAY 139 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ + RV+F+E+T+ IR A ++PGE+++ +V AQ+ARR +DR+VGY +SP Sbjct: 140 HIASELEALPVPPKRVLFHELTEGGIRSALSEPGEIDVRKVEAQKARRALDRIVGYTISP 199 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA---LALQV 238 LLW ++ RGLSAGRVQSVAVRLV +RE EI FV EE+W +DA ++ Sbjct: 200 LLWDRVRRGLSAGRVQSVAVRLVCDREDEIARFVREEYWTIDARFRPGDPRVPPTFLSRL 259 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 + + + AV + + R++V E P P TS LQQ A+ RL Sbjct: 260 DRVSGEKPVLPDARTAGQAVERIRRERFTVGEITRADKKRNPSPPLTTSRLQQEAANRLR 319 Query: 299 FGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 F KKTM +AQ+LYE G ITYMRTDS +S +A R +I + LP Sbjct: 320 FSAKKTMTVAQKLYEGVDLPGQGPVGLITYMRTDSVRVSPEAAEAARSWIRQHH-PDGLP 378 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMTPAKY 408 Y +++ Q+AHEAIRPSDV ESL ++ D +LY LIW+ FV QM+PA Y Sbjct: 379 ARAPAYKNRKGIQDAHEAIRPSDVRRTPESLQGSIDPDLFRLYDLIWKSFVESQMSPALY 438 Query: 409 DSTTLTVGAG-DFRLKARGRILRFDGWTKVMP--------ALRKGDEDRILPAVNKGDAL 459 TT+ V +A GR+L+ G+ + A EDR+LP + G+ + Sbjct: 439 LQTTVLVEGDQGDVFRASGRVLKSPGFLALRGLSVAPEDGAGEGEGEDRLLPPLETGEIV 498 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 +L E+TP QHFT+PP R+SEASL++ELE++GIGRPSTYA+I+STIQDR YV + RFY Sbjct: 499 SLEEVTPDQHFTEPPPRYSEASLIRELEEKGIGRPSTYATILSTIQDREYVEKKENRFYP 558 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 +G+ V L E+F +LM+ FTA+ME LDQV E ++ V+ F++ F +++KA+ Sbjct: 559 TDLGKAVNSLLVESFPDLMSVRFTARMEEELDQVEEGERGYRDVVGDFYTPFHHEVEKAK 618 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPE 639 K + V T + CP C M + G +L CS Y CKTT N E Sbjct: 619 KGGMTNLKKL--EVPTDVSCPVCQAPMNRKWGKNGSYLSCSRYP-----ECKTTRNFTEE 671 Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF 699 N + ++E E C C M C P C + Sbjct: 672 NGQIRIVEEALPEGE------VCHVCQAPMVIKK-GRFGTFLACSRYPECKTTRPWPPKA 724 Query: 700 R---IKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDP 755 C +C S M K GRFG + AC+ ECK TR + Sbjct: 725 EASLPAVSPAEAPVCPECSSPMVQKRGRFGSFWACSRYPECKGTRPL------------- 771 Query: 756 VPLPELPCEK--SDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 PC V R G G F + +P+ Sbjct: 772 --ATGHPCPVKGCKGELVPRRGKRGTFYGCSRYPECTFLLNGEP 813 Score = 94.8 bits (234), Expect = 1e-17, Method: Composition-based stats. Identities = 40/183 (21%), Positives = 68/183 (37%), Gaps = 14/183 (7%) Query: 667 TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKG-----YDGPIVECEKCGSEMHLK 721 +D + V G+ T +E+E+ + V C C + M+ K Sbjct: 587 EELDQVEEGERGYRDVVGDFYTPFHHEVEKAKKGGMTNLKKLEVPTDVSCPVCQAPMNRK 646 Query: 722 MGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVF 780 G+ G Y++C+ ECK TR E+ +P E+ C A V++ G G F Sbjct: 647 WGKNGSYLSCSRYPECKTTRNFTEENGQIRIVEEALPEGEV-CHVCQAPMVIKKGRFGTF 705 Query: 781 LAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYV 840 LA + +P+ + TR + P A+AP + + + R + Sbjct: 706 LACSRYPECKTTRPWPPKAEASLPAVSP------AEAPVCPECSSPMVQKRGRFGS-FWA 758 Query: 841 SSE 843 S Sbjct: 759 CSR 761 Score = 73.6 bits (179), Expect = 3e-11, Method: Composition-based stats. Identities = 27/152 (17%), Positives = 38/152 (25%), Gaps = 37/152 (24%) Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 P + CP C M + G F CS Y CK T L Sbjct: 729 PAVSPAEAPVCPECSSPMVQKRGRFGSFWACSRYP-----ECKGTRPLA----------- 772 Query: 649 EDAETNALRAKRRCPK--CGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDG 706 CP C + + C P C + + Sbjct: 773 ---------TGHPCPVKGCKGELVPRRGKRG-TFYGCSRYPECTF---------LLNGEP 813 Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTNEECKN 738 C C ++ G+ + C NE C + Sbjct: 814 VRDPCPDCQFPYRVRTGKKSVDLVCPNEACSH 845 >UniRef50_C1F6V0 DNA topoisomerase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F6V0_ACIC5 Length = 878 Score = 692 bits (1785), Expect = 0.0, Method: Composition-based stats. Identities = 309/842 (36%), Positives = 441/842 (52%), Gaps = 93/842 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+LVIVESPAKAKTINKYLG D+ V++S+GHI+DLP Sbjct: 1 MSKSLVIVESPAKAKTINKYLGKDFQVEASIGHIKDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHN-WEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 N++GVD +E V+PGKEKVV +L++LA K D IYLA D DREGEAI Sbjct: 39 -------KNKLGVDVEKGTFEPELIVIPGKEKVVDKLRKLATKVDTIYLAPDPDREGEAI 91 Query: 120 AWHLREVIGGDDAR---YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 A HL + + + R+ FNEIT A+ A + ++ + V+AQQ RR +DR+VG Sbjct: 92 AAHLEDELKAVVKKPEAIRRITFNEITPKAVTAALDHARSVDRNLVDAQQTRRVLDRIVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-EALA 235 Y +SPLLW K+ RGLSAGRVQ+VA+RL+VERE++IKAF P E+W +DA T + Sbjct: 152 YQISPLLWDKVRRGLSAGRVQTVALRLIVEREQQIKAFKPVEYWTIDAVLKTGGNPQEFT 211 Query: 236 LQVTHQNDKPFRPV--------NKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + + R +++ T V+ L KA +SV E E K APF TS Sbjct: 212 AHFIGIDGERARVETVDAPALPDQKLTDEVVAQLHKADWSVREVERKERKRNAPAPFTTS 271 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYI 339 LQQ AS +LGF VK+TM +AQRLYE G ITYMRTDST ++ +A+ VRGYI Sbjct: 272 KLQQDASRQLGFNVKRTMGVAQRLYEGIEIGGDAVGLITYMRTDSTRVAPEAIEAVRGYI 331 Query: 340 SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQF 398 GK YLP +PN + SK+++Q+AHEAIRP+D N+ + ++ + + KLY+LIWR+F Sbjct: 332 QKKVGKDYLPAAPNAFKSKKDAQDAHEAIRPADPNLHPDDIRKYLSDEQYKLYRLIWRRF 391 Query: 399 VACQMTPAKYDSTTLTVGA---GDFRLKARGRILRFDGWTKVMPALRKGDE------DRI 449 VA QM PA +D TT+ + A + + G +++FDG+ +V +++ + Sbjct: 392 VASQMMPAIFDQTTVEIAARADRRYDFRVTGSVMKFDGFLRVYEEVKEKKDADDEALANK 451 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 LPA+N GD L L L P QH+T+PP R++EASLVKELE+RGIGRPSTYA+II+TIQDR Y Sbjct: 452 LPALNNGDRLALSALKPEQHYTEPPPRYNEASLVKELEERGIGRPSTYATIINTIQDREY 511 Query: 510 VRVEN---RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 V+ RF ++G +VT L +NF + + +TA++E LD + + + W +L+ Sbjct: 512 VQKMGGRTGRFIPTEIGTVVTGLLVKNFPYIFDTKYTARLEEELDDIEDGKERWTDLLNG 571 Query: 567 FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPP 626 F+ F +L A + E+ T C CG + ++ G F CS Y Sbjct: 572 FYDHFEDELKDAATNMEDIKR---MEKPTDQKCDICGSPLVLKWGKFGSFYACSAYDKKK 628 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNN 686 K+ C T L E + CG M P C Sbjct: 629 KDGCTFTKENYEAKPNLAAPSDEAEQEEEYCEN-----CGRVMVLR-NGPWGPFMACPGY 682 Query: 687 ---PTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKI 742 P C + + K +C KCG ++ L+ G++G++++C+ +CK ++ Sbjct: 683 NEDPPCKTVRRLNQKQQQKPPQPLDEKCPKCGEQLVLRHGQYGEFISCSGYPKCKYIKQN 742 Query: 743 LRNGEVAPPKEDPVPLPELPCEKSD-AYFVLRDGAAG-VFLAANTFPKSRETRAPLVEEL 800 + C + V + G F + +PK T + Sbjct: 743 ---------------TIGMKCPQCKVGEIVEKKARRGNFFYGCSEYPKCDFTANYKPVDR 787 Query: 801 YR 802 Sbjct: 788 KC 789 Score = 75.5 bits (184), Expect = 9e-12, Method: Composition-based stats. Identities = 32/170 (18%), Positives = 51/170 (30%), Gaps = 40/170 (23%) Query: 596 SIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNA 655 CP CG ++ +R G F+ CSGY +CK Sbjct: 707 DEKCPKCGEQLVLRHGQYGEFISCSGYP-----KCKY--------------------IKQ 741 Query: 656 LRAKRRCPKCG-TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC 714 +CP+C + + C P CD + R +C +C Sbjct: 742 NTIGMKCPQCKVGEIVEKKARRGNFFYGCSEYPKCDFTANYKPVDR---------KCPEC 792 Query: 715 GSE-MHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPC 763 GS + K + G Y+ C N + + K+ + C Sbjct: 793 GSAYLMEKTLKSGVYLVCPNNK----KPSAEEETTTKRKKKGDTGEGVSC 838 Score = 45.1 bits (105), Expect = 0.011, Method: Composition-based stats. Identities = 30/145 (20%), Positives = 42/145 (28%), Gaps = 26/145 (17%) Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTC--GRKMGIRTASTGVFLGCSGYALPPKER 629 Q + + + + CP C G + + F GCS Y + Sbjct: 721 HGQYGEFISCSGYPKCKYIKQNTIGMKCPQCKVGEIVEKKARRGNFFYGCSEYP-----K 775 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 C T N P R+CP+CG+A VC NN Sbjct: 776 CDFTANYKP-------------------VDRKCPECGSAYLMEKTLKSGVYLVCPNNKKP 816 Query: 690 DGYEIEEGEFRIKGYDGPIVECEKC 714 E + + KG G V C Sbjct: 817 SAEEETTTKRKKKGDTGEGVSCSFT 841 Score = 44.7 bits (104), Expect = 0.014, Method: Composition-based stats. Identities = 13/71 (18%), Positives = 25/71 (35%) Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAP 818 + C+ + VL+ G G F A + + K ++ +E Y + L Sbjct: 597 TDQKCDICGSPLVLKWGKFGSFYACSAYDKKKKDGCTFTKENYEAKPNLAAPSDEAEQEE 656 Query: 819 QQDPEGNKTMV 829 + + MV Sbjct: 657 EYCENCGRVMV 667 >UniRef50_A8ZW15 DNA topoisomerase n=3 Tax=Desulfobacteraceae RepID=A8ZW15_DESOH Length = 758 Score = 690 bits (1781), Expect = 0.0, Method: Composition-based stats. Identities = 285/803 (35%), Positives = 413/803 (51%), Gaps = 76/803 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K ++IVESP K KTI KY G+ Y V ++ GH+RDLP Sbjct: 1 MNKPVIIVESPTKVKTITKYTGNAYSVTATSGHLRDLPPHE------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +G+D + + Y + GK+KV+ LK AD IYLA D DREGEAIA Sbjct: 42 ----------LGIDIDNGFAPDYVNIKGKQKVIKALKSAVGDADDIYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ +++ R+ RV+F+E+TK I++ +P ELN +R +AQQARR +DR+VGY +S Sbjct: 92 FHVADLLKKKGRRFHRVMFHELTKTGIQKGLTEPTELNRNRYDAQQARRILDRLVGYQIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLW+K+ GLSAGRVQSVAVR++ +REREI AF P+E+W + A+ + ++ Sbjct: 152 PLLWRKVRNGLSAGRVQSVAVRIICDREREIFAFDPQEYWSITAALEGANPPRFEAKLVK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + K N+ + V L + ++V + K P PF TS LQQ A +LGF Sbjct: 212 KGTKNITIGNQAEADRIVDELSRQAFTVDKIVQKTIKRNPQPPFTTSKLQQEAIRKLGFT 271 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 KKTM +AQ LYE G ITYMRTDST ++ +A + +I FG Y P+ Sbjct: 272 AKKTMAVAQELYEGIDLGPGEPVGLITYMRTDSTRIAPEAAHEALAHIRSVFGNDYAPDR 331 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 P +A+K Q+AHEAIRP+ ++ ES+K + D LY LIW++FVA QM+ A+ D Sbjct: 332 PRFFANKNKVQDAHEAIRPTGISYTPESVKRYLSKDQLTLYTLIWKRFVASQMSEAQIDQ 391 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALR------KGDEDRILPAVNKGDALTLVEL 464 T+T+ AGD+ L G +RF G+ + D+ LP +++ + L L+EL Sbjct: 392 KTITIAAGDYLLSVSGSTVRFPGFMALYQPEEDKNGAPDKDKGDKLPQLDEKEVLKLIEL 451 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 P QHFT PP RFSEASLVKELE+ GIGRPSTYA+I+STI+D+GYV + N+ F ++G Sbjct: 452 DPKQHFTTPPPRFSEASLVKELEENGIGRPSTYATILSTIRDKGYVDLINKAFRPTELGF 511 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 IV D L ENF +++ +FTA MEN LD++ + + + +L+ F+ F+Q+++ A+ Sbjct: 512 IVNDLLVENFPTILDIEFTANMENDLDRIESDQLQAVRLLERFYGPFSQRIEAAKDRMRS 571 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 T + CP CG+++ I+ G FL CSGY CK + N ++ Sbjct: 572 VKGVGMD---TGLSCPECGKELKIKLGKNGPFLACSGYP-----DCKFSRNYARTDKGTV 623 Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 D ++ C KCG+ M C P C + Sbjct: 624 EPVEPDLTVAEGKS---CEKCGSPMVVKQ-GRYGDFLACSAYPDCKSTQSLNSGANAAPI 679 Query: 705 DGPIVECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 E C ++ K + GK + C+ +C ++ Sbjct: 680 GVKCPE-PGCNGDIVEKKSKRGKVFYGCSRFPKCTFASWDKP--------------VDMA 724 Query: 763 CEKSDAYFVLRDG--AAGVFLAA 783 C A FV+ G L Sbjct: 725 CPDCGAPFVVEKTTKKEGTVLTC 747 Score = 94.4 bits (233), Expect = 2e-17, Method: Composition-based stats. Identities = 36/142 (25%), Positives = 62/142 (43%), Gaps = 5/142 (3%) Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKI--LRNGEVAPPKEDPVPLPELPC 763 + C +CG E+ +K+G+ G ++AC+ +CK +R G V P + D C Sbjct: 579 TGLSCPECGKELKIKLGKNGPFLACSGYPDCKFSRNYARTDKGTVEPVEPDLTVAEGKSC 638 Query: 764 EKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV-EELYRFRDRLPEKLRYLADAPQQDP 822 EK + V++ G G FLA + +P + T++ + PE D ++ Sbjct: 639 EKCGSPMVVKQGRYGDFLACSAYPDCKSTQSLNSGANAAPIGVKCPEP-GCNGDIVEKKS 697 Query: 823 EGNKTMVRFSRKTKQQYVSSEK 844 + K SR K + S +K Sbjct: 698 KRGKVFYGCSRFPKCTFASWDK 719 Score = 65.9 bits (159), Expect = 7e-09, Method: Composition-based stats. Identities = 15/98 (15%), Positives = 35/98 (35%), Gaps = 2/98 (2%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 +++I + + L C + ++ G G FLA + +P + +R Sbjct: 558 FSQRIEAAKDRMRSVKGVGMDTGLSCPECGKELKIKLGKNGPFLACSGYPDCKFSRNYAR 617 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKT 835 + P+ +A+ + G+ +V+ R Sbjct: 618 TDKGTVEPVEPD--LTVAEGKSCEKCGSPMVVKQGRYG 653 >UniRef50_Q67PC7 DNA topoisomerase n=3 Tax=Bacteria RepID=Q67PC7_SYMTH Length = 735 Score = 689 bits (1779), Expect = 0.0, Method: Composition-based stats. Identities = 291/797 (36%), Positives = 426/797 (53%), Gaps = 113/797 (14%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+L+IVESPAKAKTI K+LG Y VK+S+GH+RDLP S Sbjct: 1 MPKSLIIVESPAKAKTIEKFLGRKYAVKASMGHVRDLPKSQ------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GV +++E Y + GK ++ EL++ A KAD +YLATD DREGEAI+ Sbjct: 42 ----------LGVSVENDFEPKYITIRGKGDILKELRESARKADRVYLATDPDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +V+ R+ F+EITK+AI++A +P ++++RV AQQARR +DR+VGY +S Sbjct: 92 WHLAQVLKLPLDEPLRIEFHEITKDAIQRAIKQPRPIDLNRVEAQQARRVLDRLVGYKLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLW+K+ RGLSAGRVQSVAVRL+V+REREI+AF PEE+W +DA +T ++ + + Sbjct: 152 PLLWRKVRRGLSAGRVQSVAVRLIVDREREIQAFQPEEYWTLDARLSTAFAQSFSARYWG 211 Query: 241 QNDKPFRPVNKEQTQAAVSLL------------------------------EKARYSVLE 270 ++ ++Q +A V + E V Sbjct: 212 MGEQKADLKTQDQVRAVVHQVAGDRLPAGNAAVSGEGTPGDPFTEVLDLAGEGLVLQVRS 271 Query: 271 REDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMR 321 + + P PF TS+LQQ AS +LGF V++TM +AQ+LYE G +TY+R Sbjct: 272 VKRREKKRNPAYPFTTSSLQQEASRKLGFSVRRTMAVAQQLYEGLPLGEEGHTGLVTYIR 331 Query: 322 TDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK 381 TDST ++ +A +I +GK Y+PE + + Q AHEAIRP+DV ES+K Sbjct: 332 TDSTRIADEAARAAAEFIERQYGKDYVPERRREPDRRAGEQGAHEAIRPTDVTRTPESVK 391 Query: 382 D-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPA 440 + D +LY+LIW +F+A QM PA D+ T+ + AG+ +A G+ +RF G+ KV Sbjct: 392 PYLTPDQYRLYRLIWERFLASQMAPAVLDTVTVELVAGEHVFRASGQSIRFPGFMKVYIE 451 Query: 441 LRK-----GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPS 495 + D +LP + +G +TL L QHFT+PP R+SEA LVK LE+RGIGRPS Sbjct: 452 GEDDDGQREEGDDLLPELAEGQQVTLQTLEARQHFTQPPPRYSEAMLVKALEERGIGRPS 511 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 TYA II TIQ RGYV ++RFY ++G +VTD L+E F ++++ +FTA +E LD+V Sbjct: 512 TYAPIIGTIQTRGYVEKRDKRFYPTELGVLVTDILKEYFPDIIDVEFTAHLEGKLDEVEE 571 Query: 556 HEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV 615 W+ ++ F+ F + L +A E+ G + ++ + C CGR M ++ G Sbjct: 572 GRVNWRELIRRFYGPFEETLKQA---EEKVGGFELEDEVSDVPCEKCGRLMVVKHGRFGK 628 Query: 616 FLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA--MDSYL 673 FL C G+ CK+T ++ E CP CGT ++ Sbjct: 629 FLACPGFP-----ECKSTKPILEE------------------TGVTCPACGTGRIVERKS 665 Query: 674 IDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSE--MHLKMGRFGKYMAC 731 R+ + C N P C+ E+ R+ C +CG+ + ++ G C Sbjct: 666 KKGGRRFYGCTNYPDCNFVSWEKPVNRL---------CPECGAPYLVEKRIKELGLSHVC 716 Query: 732 TNEECKNTRKILRNGEV 748 +C + EV Sbjct: 717 KQPDCGYVEPVESMEEV 733 Score = 61.7 bits (148), Expect = 1e-07, Method: Composition-based stats. Identities = 22/115 (19%), Positives = 37/115 (32%), Gaps = 16/115 (13%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 + + E E + ++PCEK V++ G G FLA FP+ + T+ L Sbjct: 587 FEETLKQAEEKVGGFELEDEVSDVPCEKCGRLMVVKHGRFGKFLACPGFPECKSTKPILE 646 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE-KDGKATGW 851 E P G + + ++ Y + D W Sbjct: 647 ETG--------------VTCPACG-TGRIVERKSKKGGRRFYGCTNYPDCNFVSW 686 >UniRef50_C9RBU3 DNA topoisomerase n=2 Tax=Bacteria RepID=C9RBU3_AMMDK Length = 686 Score = 687 bits (1773), Expect = 0.0, Method: Composition-based stats. Identities = 279/749 (37%), Positives = 399/749 (53%), Gaps = 78/749 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+IVESPAKA+T++K+LGS ++VK+S+GH+RDLP S Sbjct: 2 KHLIIVESPAKARTLSKFLGSQFLVKASMGHVRDLPKSE--------------------- 40 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +GVD + + Y + GK KV+ ELK KAD + +A+D DREGEAIAWH Sbjct: 41 --------LGVDLENGFTPKYVTIRGKGKVIQELKSYVAKADTVLMASDPDREGEAIAWH 92 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L ++G RV F+EITKNA+ + P ++++RVNAQQARR +DR+VGY +SPL Sbjct: 93 LCHLLGIPPETPCRVEFHEITKNAVLNSLKSPRPIDLNRVNAQQARRVLDRLVGYGLSPL 152 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LW+K+ RGLSAGRVQSVA+RLVVERE EI+AF PEE+W++ TP E + ++ Sbjct: 153 LWRKVKRGLSAGRVQSVALRLVVEREEEIEAFKPEEYWDLAVWLLTPEEERVLARLARFK 212 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K F E+ + S A + V + + P PF TS + Q A+ RLG ++ Sbjct: 213 GKKFTCRTAEEVERVKSATASAAFRVARVVRQERSKAPPLPFTTSQMVQEANRRLGMRLE 272 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE-SP 352 +TM +AQ+LYE G ITY+RTDST +S++A +I +++G +++ + P Sbjct: 273 RTMAVAQQLYEGVDLGPEGPVGLITYIRTDSTRVSEEAKERAWAFIKEHYGAEFVGDVPP 332 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 + +K ++AHEAIRP+DV E +K + D KLY+LIW +F+A M PAKY T Sbjct: 333 KERKAKGRVEDAHEAIRPTDVYRTPEKVKPYLTPDQYKLYRLIWERFLAAHMAPAKYFLT 392 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + GD+ A GR L F G+ ++ + +E + LP + +G+ LT E P QHFT Sbjct: 393 RAEIEVGDYTFYATGRQLLFPGFLRLWRPEEEEEEGK-LPPLREGEVLTFQEFVPQQHFT 451 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 PP R++E +LVK LE++G+GRPSTYA I TI RGYV ++ + +G V + L+ Sbjct: 452 TPPPRYTEGTLVKALEEKGVGRPSTYAPTIETILKRGYVVRVDKYLHPTPLGRTVVELLK 511 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 E+F +++ FTA ME LD V +A+W +L F+ F+Q L +A+ E+ + Sbjct: 512 EHFPGIVDVGFTAAMEEKLDLVEEGQADWVDILREFYQSFSQDLVRADAAIEKVSLPDTF 571 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 T I CP CG M +T G FL CSGY Sbjct: 572 ---TDISCPRCGCPMVKKTGRYGEFLACSGYPECQ------------------------- 603 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVEC 711 + +CP+CG + R + C P C+ E C Sbjct: 604 MRMPVGTGVKCPRCGGELVKRRSKKGRYFYGCNRYPECNFVVWSEPVPEP---------C 654 Query: 712 EKCGSEMHLKMGRFGKYMACTNEECKNTR 740 +CGS M + K + CTNE C R Sbjct: 655 PECGSLMVRRGRGKKKRVICTNESCGYQR 683 Score = 77.1 bits (188), Expect = 3e-12, Method: Composition-based stats. Identities = 23/147 (15%), Positives = 35/147 (23%), Gaps = 28/147 (19%) Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 E CP+CG M + C P C Sbjct: 563 EKVSLPDTFTDISCPRCGCPMV-KKTGRYGEFLACSGYPECQMRMPVG----------TG 611 Query: 709 VECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKS 766 V+C +CG E+ + + G+ + C EC PC + Sbjct: 612 VKCPRCGGELVKRRSKKGRYFYGCNRYPECNFVVWSEP--------------VPEPCPEC 657 Query: 767 DAYFVLRDGAAGVFLAANTFPKSRETR 793 + V R + R Sbjct: 658 GSLMVRRGRGKKKRVICTN-ESCGYQR 683 Score = 64.0 bits (154), Expect = 3e-08, Method: Composition-based stats. Identities = 22/110 (20%), Positives = 37/110 (33%), Gaps = 20/110 (18%) Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSR-----ETRAPLVEELYRFRDRLPE 809 P ++ C + V + G G FLA + +P+ + T R + Sbjct: 568 PDTFTDISCPRCGCPMVKKTGRYGEFLACSGYPECQMRMPVGTGVKCPRCGGELVKRRSK 627 Query: 810 KLRYL---------------ADAPQQDPEGNKTMVRFSRKTKQQYVSSEK 844 K RY P+ PE MVR R K++ + + + Sbjct: 628 KGRYFYGCNRYPECNFVVWSEPVPEPCPECGSLMVRRGRGKKKRVICTNE 677 >UniRef50_D0LR99 DNA topoisomerase n=169 Tax=cellular organisms RepID=D0LR99_HALO1 Length = 894 Score = 687 bits (1772), Expect = 0.0, Method: Composition-based stats. Identities = 304/810 (37%), Positives = 419/810 (51%), Gaps = 88/810 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GKALV+VESPAKA+TI KYLG DY VK+SVGHI+DLP Sbjct: 136 GKALVVVESPAKARTIGKYLGPDYTVKASVGHIKDLP----------------------- 172 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 N++GVD +E Y V+ K+KV+SE+++ AE+ + +YLA D DREGEAIAW Sbjct: 173 ------KNKIGVDVDQAFEPEYVVISDKKKVISEIRKAAERVEEVYLAPDPDREGEAIAW 226 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ E I + R++ NEITK + A P L+ ++ +AQQARR +DR+VGY +SP Sbjct: 227 HIAEEIKPINDNIKRILINEITKKGVNHAIANPTVLDTNKTDAQQARRILDRLVGYEISP 286 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 +LWKK+ RGLSAGRVQSVAVRL+VER++EI AF PEE+W VD + P A ++ Sbjct: 287 ILWKKVRRGLSAGRVQSVAVRLLVERDKEIAAFTPEEYWSVDVDCSAPEPPPFAAKIHRW 346 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + P + Q L +V + E K +P PFITS LQQ AS +L F Sbjct: 347 DGAKAEPKTEAQATEIADELRAQAAAVAKVERKERRRRPQPPFITSKLQQEASRKLRFSA 406 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 K+TM +AQRLYE G ITYMRTDST +S DA+ +R +I +G ++LP P Sbjct: 407 KRTMALAQRLYEGIELGSEGPLGLITYMRTDSTRISDDALAALRTHIQGTYGPEFLPAKP 466 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ------KLYQLIWRQFVACQMTPA 406 + Y S + +Q+AHEAIRP+ + E + A + KLY LIW++FVA QM PA Sbjct: 467 HTYKSPKRAQDAHEAIRPTTLEYPPERVAKALAGHREGKELVKLYTLIWQRFVASQMAPA 526 Query: 407 KYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE--------DRILPAVNKGDA 458 YD T + + G L+A G++++F G+ V A DE D++LP + +G A Sbjct: 527 VYDQTAVDIQCGRAILRASGQVMKFPGFLSVYRAQETDDEKAETAADQDKLLPHLEEGMA 586 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFY 518 + + P QHFT+PP RF+EASLVKELE+RGIGRPSTYASIISTI DRGYV RF+ Sbjct: 587 IHFDAIRPEQHFTQPPPRFTEASLVKELEERGIGRPSTYASIISTITDRGYVERREARFF 646 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 ++G IV D L E+F ++M+ DFTA ME LD+V E +W+ +L F+ F ++ A Sbjct: 647 PTELGAIVNDLLVESFPKIMDVDFTAAMEADLDKVEEGERDWRELLGGFYEPFRGNIEHA 706 Query: 579 EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVP 638 +++ + + T C CG M I+ G FL C Y C+ T + Sbjct: 707 KENMRDVKREE---IPTDHVCEKCGAPMVIKWGRNGSFLACQAYP-----DCRNTKEINR 758 Query: 639 ENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGE 698 +G C +CG M C P C + Sbjct: 759 N------PDGSFEIVPEQTTDETCSECGAPMVVKR-GRFGAFLACSTYPECKNTQPISLG 811 Query: 699 FRIKGYDGPIVECEKCGSEMHLKMGRFG-KYMACTNEECKNTRKILRNGEVAPPKEDPVP 757 CG + K R G + C+N + G + P+ Sbjct: 812 VDCPKDG--------CGGFLTEKRSRRGKPFYGCSN--------YSKTGCDFVTWDRPIA 855 Query: 758 LPELPCEKSDAY-FVLRDGAAGVFLAANTF 786 C +A V ++ G + + Sbjct: 856 ---EACPVCEASFLVKKETRRGTTVRCLSC 882 Score = 91.7 bits (226), Expect = 1e-16, Method: Composition-based stats. Identities = 41/153 (26%), Positives = 64/153 (41%), Gaps = 19/153 (12%) Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAP 750 + E + CEKCG+ M +K GR G ++AC +C+NT++I RN + + Sbjct: 705 HAKENMRDVKREEIPTDHVCEKCGAPMVIKWGRNGSFLACQAYPDCRNTKEINRNPDGSF 764 Query: 751 PKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEK 810 P + C + A V++ G G FLA +T+P+ + T+ Sbjct: 765 E-IVPEQTTDETCSECGAPMVVKRGRFGAFLACSTYPECKNTQPI--------------- 808 Query: 811 LRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 D P+ G T R SR+ K Y S Sbjct: 809 -SLGVDCPKDGCGGFLTEKR-SRRGKPFYGCSN 839 Score = 88.2 bits (217), Expect = 1e-15, Method: Composition-based stats. Identities = 31/152 (20%), Positives = 46/152 (30%), Gaps = 26/152 (17%) Query: 650 DAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF----RIKGYD 705 D + + C KCG M C P C + I Sbjct: 712 DVKREEIPTDHVCEKCGAPMVIK-WGRNGSFLACQAYPDCRNTKEINRNPDGSFEIVPEQ 770 Query: 706 GPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCE 764 C +CG+ M +K GRFG ++AC+ ECKNT+ + C Sbjct: 771 TTDETCSECGAPMVVKRGRFGAFLACSTYPECKNTQP---------------ISLGVDCP 815 Query: 765 K--SDAYFVLRDGAAG-VFLAANTFPK--SRE 791 K + + G F + + K Sbjct: 816 KDGCGGFLTEKRSRRGKPFYGCSNYSKTGCDF 847 Score = 62.4 bits (150), Expect = 8e-08, Method: Composition-based stats. Identities = 25/112 (22%), Positives = 37/112 (33%), Gaps = 5/112 (4%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 I E + + CEK A V++ G G FLA +P R T+ Sbjct: 699 FRGNIEHAKENMRDVKREEIPTDHVCEKCGAPMVIKWGRNGSFLACQAYPDCRNTK---- 754 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKAT 849 E+ R D E + G +V+ R S+ + K T Sbjct: 755 -EINRNPDGSFEIVPEQTTDETCSECGAPMVVKRGRFGAFLACSTYPECKNT 805 >UniRef50_C1XK22 DNA topoisomerase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XK22_MEIRU Length = 836 Score = 684 bits (1765), Expect = 0.0, Method: Composition-based stats. Identities = 298/889 (33%), Positives = 428/889 (48%), Gaps = 124/889 (13%) Query: 1 MG-KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKP 59 M L++VESPAKAK+I K LG+ Y V++S GHI DLP Sbjct: 1 MPDSTLIVVESPAKAKSIQKMLGAGYEVRASKGHIADLPEHE------------------ 42 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 +GVD ++ Y V K+ +V ELK+ A + +ATD DREGEAI Sbjct: 43 -----------LGVDTQADFAPQYTVKKDKQPIVEELKRAARG-KRVLIATDPDREGEAI 90 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ ++G + RV F+EIT +R A KP ++ V+AQQARR +DR+VGY + Sbjct: 91 GWHVARLLGLNPQTPLRVEFHEITPKVVRAAVQKPRPIDQSLVDAQQARRVLDRLVGYQL 150 Query: 180 SPLLWKKIAR-GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 SP+L + R LSAGRVQSVA+RL+VERE+EI+AFVP+E W ++ + + A+ Sbjct: 151 SPVLSMEFRRRALSAGRVQSVALRLLVEREQEIEAFVPQEHWSLEGRFESEGQQFKAMLY 210 Query: 239 TH-----QNDKPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFITSTLQQA 292 + Q+ F +++Q Q L + Y + E + PFITSTLQQA Sbjct: 211 SLGSERVQSGDKFLITSEKQAQEIARLAKDVSGYRIGSIERRERRRNAPPPFITSTLQQA 270 Query: 293 ASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFG 344 AS+RLG+ +TM +AQ+LYE G ITYMRTDST +SQ+A+ VR +I +FG Sbjct: 271 ASSRLGWTASRTMRVAQKLYEGIDLPEGTVGLITYMRTDSTRVSQEALAEVRAFIPRHFG 330 Query: 345 KKYLPESPNQYASKE--NSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 YLPE PN +A K+ N+Q+AHEAIRP+ ++L+ + + +LYQLIW++FVA Sbjct: 331 PAYLPEKPNFFAGKKAANAQDAHEAIRPTSTERTPDALRKHLSDEEYRLYQLIWQRFVAS 390 Query: 402 QMTPAKYDSTTLTVG------AGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNK 455 QMTPA +D TT+TV +GD +A G +L+FDG+ +V + + LP + + Sbjct: 391 QMTPAVFDQTTVTVVGASGTPSGDLIFRAVGSVLKFDGYLRVYGREEGDEAENRLPPLQE 450 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 + L+E+TP QHFT+PP R+++ASLVK LE+ GIGRPSTYA I T++ RGY+ + Sbjct: 451 NASARLLEVTPEQHFTEPPPRYTDASLVKTLEEMGIGRPSTYAPTIDTLERRGYLERSGK 510 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 +G VT L ++F +++ YDFTAQ+E+ LD++ +A W V+ F+ F + Sbjct: 511 SLKPTPLGREVTGYLIKSFPDVVAYDFTAQLESRLDEIEEGKAAWPKVVREFYEPFLKDF 570 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 K + CP CGR + ++ + G FLGC+GY CK T Sbjct: 571 AKVPQKL----------------CPKCGRPLELKVSRFGQFLGCTGYP-----ECKHT-- 607 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE 695 E + + CP CG C P C Sbjct: 608 -----------ERLELKKEPEPIGEACPACGEGQLVRRHGRYGSFISCSRYPECKYTRD- 655 Query: 696 EGEFRIKGYDGPIVECEKC-GSEMHLKMGRFG-KYMACTNEECKNTRKILRNGEVAPPKE 753 +EC KC E+ K + G Y C N C Sbjct: 656 -------EAPSTGIECPKCHAGEVVQKTSKRGKPYYRCNNPACDFL-------------- 694 Query: 754 DPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRY 813 PL C V + G +G A P P +E L + R + K Sbjct: 695 SFDPLLPDKCPLCGWNEVAK-GRSGK-RACTN-PGCERYGGPKLEALNQRRTKSSSKTSG 751 Query: 814 LADAPQQDPEGN--------KTMVRFSRKTKQQYVSSEKDGKATGWSAF 854 A +D + + +Q V+ G+ +A Sbjct: 752 TAKNKVKDRAKASATWADLEPFITKAGLTPEQAEVARRTQGQQKQVAAV 800 >UniRef50_D1BMP2 DNA topoisomerase n=6 Tax=Firmicutes RepID=D1BMP2_VEIPT Length = 791 Score = 680 bits (1755), Expect = 0.0, Method: Composition-based stats. Identities = 289/767 (37%), Positives = 406/767 (52%), Gaps = 79/767 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK LVIVESPAK+KTI K+LG +YVVK+S+GH+RDLP S Sbjct: 72 GKVLVIVESPAKSKTIEKFLGPNYVVKASMGHLRDLPKSQ-------------------- 111 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +G+D H++ Y L ++KV+ EL A+++ + LATD DREGEAI+W Sbjct: 112 ---------IGIDIEHDFTPRYSNLVTRKKVIDELVSYADESSAVLLATDPDREGEAISW 162 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL ++ D R+ FNEITKNA+ +A + P ++++ V+AQQARR +DR+VGY +SP Sbjct: 163 HLAYILNVDPTSTCRITFNEITKNAVAEALDSPRTIDMNMVDAQQARRVLDRIVGYKLSP 222 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLWKK+ +GLSAGRVQSVAVRL+ EREREI+AFVP+E+W ++ + TP EA ++TH Sbjct: 223 LLWKKVCKGLSAGRVQSVAVRLICEREREIQAFVPQEYWTIEGNFETPKKEAFIAELTHI 282 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + + QA V + V E + + K PF TSTLQQ +L FG Sbjct: 283 KGEKIDITTESDAQAIVDAIGNEDAVVTNIEKRKRSRKAVPPFTTSTLQQDGVRKLNFGA 342 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 K+TMM+AQ LYE G ITYMRTDST +S++ M + +I N+G+ Y P P Sbjct: 343 KRTMMIAQHLYEGLEIGSYGHVGLITYMRTDSTRISKEMQAMAKDFILRNYGEDYYPSKP 402 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 N Y SK ++Q+AHEAIRP+ + + + ++ + D KLY LIW +F+A QM P + +ST Sbjct: 403 NVYGSKGSAQDAHEAIRPTSLELTPKMVEPFLSRDELKLYTLIWNRFMASQMAPQQNEST 462 Query: 412 TLTVGA-GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 T+ + D+ KA G + F G++ V +K D + LPA+ K A VE+ P QHF Sbjct: 463 TIELNVKNDYTFKATGSRVIFPGFSAVYEDAKKEDVPQ-LPALKKNYAAHTVEVLPEQHF 521 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP R+SEASL+K LE+ GIGRPSTYA I+ TI R YV N++F ++G +V D L Sbjct: 522 TQPPPRYSEASLIKTLEELGIGRPSTYAPILDTIVSRNYVENTNKQFVPTELGFVVVDFL 581 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 F +++N FT +E LD +A+ + + VL F+ F Q+L+ A Sbjct: 582 ITYFEKIINTGFTRDLEEELDAIASGKDTYVKVLSDFYEVFAQELEDASDVDRIEIASM- 640 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 + C C M + G FL CS + CK T + Sbjct: 641 ---ESDEICELCNSPMVYKFGRYGKFLACSNFP-----ECKNTKPI-------------- 678 Query: 651 AETNALRAKRRCPKCGT-AMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV 709 + CPKC + R + C P CD ++ Sbjct: 679 ----TVGTGVTCPKCKEGEIVERKSRRGRIFYGCNRYPQCDFTLWDKPTHDF-------- 726 Query: 710 ECEKCGSEMHLKMGRFGKYMA-CTNEECKNTRKILRNGEVAPPKEDP 755 CE CGS M K + G C+NE C + + E+P Sbjct: 727 -CETCGSIMVEKTYKNGTVKKFCSNETCPTRPPKKTRKKKSEASEEP 772 Score = 70.1 bits (170), Expect = 3e-10, Method: Composition-based stats. Identities = 28/86 (32%), Positives = 36/86 (41%), Gaps = 16/86 (18%) Query: 711 CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD-A 768 CE C S M K GR+GK++AC+N ECKNT+ I + C K Sbjct: 646 CELCNSPMVYKFGRYGKFLACSNFPECKNTKPITVG-------------TGVTCPKCKEG 692 Query: 769 YFVLRDGAAGV-FLAANTFPKSRETR 793 V R G F N +P+ T Sbjct: 693 EIVERKSRRGRIFYGCNRYPQCDFTL 718 Score = 58.6 bits (140), Expect = 1e-06, Method: Composition-based stats. Identities = 17/96 (17%), Positives = 31/96 (32%), Gaps = 17/96 (17%) Query: 757 PLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLAD 816 + CE ++ V + G G FLA + FP+ + T+ Sbjct: 640 MESDEICELCNSPMVYKFGRYGKFLACSNFPECKNTKPIT----------------VGTG 683 Query: 817 APQQDPEGNKTMVRFSRKTKQQYVSSE-KDGKATGW 851 + + + R SR+ + Y + T W Sbjct: 684 VTCPKCKEGEIVERKSRRGRIFYGCNRYPQCDFTLW 719 >UniRef50_Q9KA23 DNA topoisomerase 1 n=107 Tax=Bacteria RepID=TOP1_BACHD Length = 690 Score = 676 bits (1745), Expect = 0.0, Method: Composition-based stats. Identities = 289/754 (38%), Positives = 408/754 (54%), Gaps = 81/754 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG Y VK+S+GH+RDLP S Sbjct: 1 MADYLVIVESPAKAKTIGKYLGKKYTVKASMGHVRDLPKSQ------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 MGVD + Y + GK V+ ELK A+K +YLA D DREGEAIA Sbjct: 42 ----------MGVDIEDEYSPRYITIRGKGPVLKELKSAAKKVKRVYLAADPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL + D+ RVVFNEITK AI+ AF P +N+D V+AQQARR +DR+VGY +S Sbjct: 92 WHLAHSLDIDETSECRVVFNEITKQAIKDAFKSPRPINMDLVDAQQARRVLDRLVGYNIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWKK+ +GLSAGRVQSVAV+++++RE+EI+AF PEE+W + + GE + Sbjct: 152 PLLWKKVKKGLSAGRVQSVAVKMIIDREKEIQAFEPEEYWSIQGTFALD-GEPFEAKFYG 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 N K +++ ++ L+ ++ V + K P +PF TS+LQQ A+ +L F Sbjct: 211 TNGKKVELKSEDDVNNVLAKLKGDQFHVDSVQKKERKRNPVSPFTTSSLQQEAARKLNFR 270 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 KKTMM+AQ+LYE G ITYMRTDST +S A + YI FGK+Y Sbjct: 271 AKKTMMLAQQLYEGIDLGKEGTVGLITYMRTDSTRISDTAKAETKEYIESKFGKEYAQNG 330 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 + SQ+AHEAIRP+ V +SLK+ + D +LY+LIW + VA QM PA D+ Sbjct: 331 TKAVKKDKKSQDAHEAIRPTSVERDPKSLKEYLSRDQLRLYKLIWERLVASQMAPAIMDT 390 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGDALTLVELTPA 467 T+ + +A G ++F G+ KV K +EDR+LP + +G +T E+ P+ Sbjct: 391 MTVDLSNEGVLFRATGSKVKFPGFMKVYIEGNDEGKKEEDRLLPNLQEGQTVTKEEIEPS 450 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFT+PP R++EA LVK +E+ GIGRPSTYA + TIQ RGYV ++ RRF ++GEIV Sbjct: 451 QHFTQPPPRYTEARLVKTMEELGIGRPSTYAPTLDTIQKRGYVALDERRFVPTELGEIVL 510 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 + + E F E+++ +FTA+ME+ LD + + +W ++D F+ F ++L AE++ +E + Sbjct: 511 ELMTEFFPEILDVEFTAKMEDDLDSIEEGKQQWIKIIDDFYKGFEERLKVAEEEMKEVEI 570 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 + T C CG +M + G F+ CS + C+ T +V E V Sbjct: 571 K---DEPTGEMCEKCGHEMVYKMGRYGKFMACSNFP-----DCRNTKPIVKEIGV----- 617 Query: 648 GEDAETNALRAKRRCPKCGT-AMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDG 706 +CPKC + +R + C P CD ++ R Sbjct: 618 -------------KCPKCEKGEIVERKSKKRRVFYGCNQYPECDFVSWDKPIAR------ 658 Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTNEECKNTR 740 C KC S + K + + C++ C Sbjct: 659 ---SCPKCSSYLVEKRTKKQVQVQCSS--CDYKE 687 Score = 59.7 bits (143), Expect = 5e-07, Method: Composition-based stats. Identities = 20/122 (16%), Positives = 42/122 (34%), Gaps = 6/122 (4%) Query: 723 GRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLA 782 G+ + ++ E E CEK V + G G F+A Sbjct: 539 GKQQWIKIIDDFYKGFEERLKVAEEEMKEVEIKDEPTGEMCEKCGHEMVYKMGRYGKFMA 598 Query: 783 ANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSS 842 + FP R T+ + E + P+ + + ++ + + ++ + +VS Sbjct: 599 CSNFPDCRNTKPIVKE----IGVKCPKCEK--GEIVERKSKKRRVFYGCNQYPECDFVSW 652 Query: 843 EK 844 +K Sbjct: 653 DK 654 >UniRef50_Q2LT40 DNA topoisomerase n=2 Tax=Bacteria RepID=Q2LT40_SYNAS Length = 769 Score = 674 bits (1740), Expect = 0.0, Method: Composition-based stats. Identities = 298/831 (35%), Positives = 422/831 (50%), Gaps = 107/831 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M +L+IVESP K KT+ KYLG+DY V +S GHI+DLP Sbjct: 1 MPDSLIIVESPTKVKTLKKYLGADYEVLASKGHIKDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +G+DP + ++ Y V+ K+KV+++LK+ A+ I+LA D DREGEAIA Sbjct: 39 -------KKTLGIDPQNEFQPTYSVIDDKKKVIADLKKAAKNVSRIFLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ E I + RV+FN++TKN I A N PG+L+ ++ AQQ RR +DR+VGY +S Sbjct: 92 WHIAEEIKAKNKEIYRVLFNDLTKNTILDAINHPGKLDFNKYEAQQTRRILDRLVGYQIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW+K+ RGLSAGRVQSVAVR++ +RE EIK F+PEE+W + + ++ Sbjct: 152 PILWEKVKRGLSAGRVQSVAVRMICDREEEIKRFIPEEYWNISVQLKGVTPPPFEARLIK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEK-------------------ARYSVLEREDKPTTSKPG 281 K + N+ Q VS L ++ V + E K + Sbjct: 212 ITGKKAKVKNEAQANEIVSRLSGGVKSGSKPTINLSEDRDLQPQFVVSKLEKKEVKKESL 271 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAV 332 PF TS LQQ AS L F KKTM AQ+LYE G ITYMRTDS +++DA+ Sbjct: 272 PPFTTSKLQQEASRLLRFSAKKTMATAQKLYEGIELGEEGPVGLITYMRTDSVRIAEDAL 331 Query: 333 NMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLY 391 VR YI +N+ +LP + SK +Q+AHEAIRPS +N + +K + AD +LY Sbjct: 332 KEVRSYIRENYDPPFLPAKARFFKSKGKTQDAHEAIRPSSMNYNPQKIKHFLSADQFRLY 391 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED---- 447 QLIW +FVA QM PA YD TT+ V A + +A+G IL+F G+T V ++ E Sbjct: 392 QLIWNRFVASQMNPALYDQTTVEVSADFYTFRAQGAILKFPGYTIVYTEGKEDKEQNEEM 451 Query: 448 ---RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTI 504 +ILP +N+G+ LTL+++TP Q FT+PP RFSEASLV+ELE++GIGRPSTYA+I+STI Sbjct: 452 ESGKILPDLNEGERLTLLKITPEQKFTQPPPRFSEASLVRELEEQGIGRPSTYAAILSTI 511 Query: 505 QDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 QDR Y R+E +F+ ++G IVT+ L +NF ++M+ FTA +EN LD + + + L Sbjct: 512 QDRNYARLEQGKFHPTELGTIVTELLVKNFPKVMDVSFTASLENQLDLIEEGKQKRIETL 571 Query: 565 DHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYAL 624 F++ F + L KA + + T + C C M I+ G F+ CS Y Sbjct: 572 QEFYAPFEEDLSKARLEMKNIKREE---TPTDLICEKCQSPMVIKWGKNGKFIACSNYPA 628 Query: 625 PPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCG 684 CK T N+ V +G CPKCG M R C Sbjct: 629 -----CKNTRNIEQGEGVERSAKG------GEMTDTVCPKCGKNMLIKHGRFGR-FLGCS 676 Query: 685 NNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKI 742 P C + C E+ K + G+ + C+N C Sbjct: 677 GYPDCKHTMPISLGVKCPQEG--------CDGEIIEKRTKKGRSFFGCSNYPNCTFAVWD 728 Query: 743 LRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAA--GVFLAANTFPKSRE 791 PC + ++ F++ + G + A Sbjct: 729 KP--------------IPEPCPQCNSPFLVEKYSRTEGSYKACPN-KDCGY 764 Score = 91.7 bits (226), Expect = 1e-16, Method: Composition-based stats. Identities = 35/159 (22%), Positives = 59/159 (37%), Gaps = 19/159 (11%) Query: 686 NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILR 744 E + + + CEKC S M +K G+ GK++AC+N CKNTR I Sbjct: 578 FEEDLSKARLEMKNIKREETPTDLICEKCQSPMVIKWGKNGKFIACSNYPACKNTRNI-E 636 Query: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFR 804 GE + + C K +++ G G FL + +P + T Sbjct: 637 QGEGVERSAKGGEMTDTVCPKCGKNMLIKHGRFGRFLGCSGYPDCKHTMPI--------- 687 Query: 805 DRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 PQ+ +G + + ++K + + S Sbjct: 688 -------SLGVKCPQEGCDGE-IIEKRTKKGRSFFGCSN 718 Score = 62.4 bits (150), Expect = 7e-08, Method: Composition-based stats. Identities = 18/118 (15%), Positives = 38/118 (32%), Gaps = 5/118 (4%) Query: 719 HLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG 778 ++ G+ + + + + +L CEK + V++ G G Sbjct: 559 LIEEGKQKRIETLQEFYAPFEEDLSKARLEMKNIKREETPTDLICEKCQSPMVIKWGKNG 618 Query: 779 VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 F+A + +P + TR E K + D G +++ R + Sbjct: 619 KFIACSNYPACKNTRNIEQGEGVERSA----KGGEMTDTVC-PKCGKNMLIKHGRFGR 671 >UniRef50_A0LDV2 DNA topoisomerase I n=7 Tax=Proteobacteria RepID=A0LDV2_MAGSM Length = 783 Score = 672 bits (1734), Expect = 0.0, Method: Composition-based stats. Identities = 301/817 (36%), Positives = 407/817 (49%), Gaps = 111/817 (13%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 A+VIVESPAKAKTINK+LG Y V ++ GHIRDLP+ Sbjct: 2 TAVVIVESPAKAKTINKFLGRGYKVVATYGHIRDLPSKNG-------------------- 41 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 VD H + Y V K V EL + + A+ + LATD DREGEAI+WH Sbjct: 42 ---------SVDTEHGFAMKYSVPKDSTKRVDELAKAVKGAEQVLLATDPDREGEAISWH 92 Query: 123 LREVIGGD----DARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 + EV+ + + RVVF+EITK AI+ A ++++D VNAQQARR +D +VG+ Sbjct: 93 VYEVLNEKKLLENVQVKRVVFHEITKTAIQDAVAHARDVDMDMVNAQQARRALDYLVGFN 152 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS------GE 232 +SPLLW+K+ RGLSAGRVQSVA+RLV ERE EI+AF E+W + A + E Sbjct: 153 LSPLLWRKVRRGLSAGRVQSVALRLVCEREAEIQAFEAREYWSITALAAQAAQSAPRPFE 212 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 A + F ++ + + +EK V E E K + P PFITSTLQQ Sbjct: 213 ARLAVADGEKLSKFSIGDEAYAKRLIKAVEKRPLYVSEIEKKQSKRNPAPPFITSTLQQE 272 Query: 293 ASTRLGFGVKKTMMMAQRLYEA-------------GYITYMRTDSTNLSQDAVNMVRGYI 339 AS +LGF KKTM +AQRLYE G I+YMRTDS NL+ +A+ +R I Sbjct: 273 ASRKLGFSAKKTMTVAQRLYEGMEVPTADGGKETVGLISYMRTDSVNLANEAIESIRKQI 332 Query: 340 SDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQ 397 +GK+YLP+SP +Y S +N+QEAHEAIRP+DV E L++ +E D +LY+LIW++ Sbjct: 333 EIRYGKEYLPKSPRKYKSSAKNAQEAHEAIRPTDVIRTPEMLREILEKDQFRLYELIWKR 392 Query: 398 FVACQMTPAKYDSTTLTVGAGD------FRLKARGRILRFDGWTKVMPALRKG------- 444 VACQM AK D + +R +A G + F G+ KV + Sbjct: 393 TVACQMAQAKIDKVAANLSVDSQDPNAAYRFRATGSSVAFAGFMKVYMEGKDEVSAQDRE 452 Query: 445 ----DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASI 500 D + ILP + G L L QHFT+PP R++EA+LVK LE GIGRPSTYA Sbjct: 453 DDDDDNESILPPLEVGQQLEQKSLDARQHFTEPPPRYTEATLVKVLESYGIGRPSTYAPT 512 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 +ST+QDRGYV+++ R+FY E +G +V L ++F ++Y+FTA +E+ LD V+ E W Sbjct: 513 MSTLQDRGYVKLDARKFYPEDVGMVVNSYLTKHFSTYVDYNFTANLEDQLDAVSRGEKSW 572 Query: 561 KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCS 620 +++ F+ F + + E CP CG + I+ G F C+ Sbjct: 573 VPLMEDFWQPF---IQQITLKDETTSKEEVTTEQIDEPCPKCGAPLSIKLGRFGKFKACT 629 Query: 621 GYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 GY CK T L E EV + C KCG M K Sbjct: 630 GYP-----ECKHTEPLNKEEEV--------SRPEPELTDIPCDKCGKPMLIKE-GRYGKY 675 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCG-SEMHLKMGRFGK-YMACTN-EECK 737 + C P C + V C CG K R GK + +C+N +CK Sbjct: 676 YGCSGAPECKNNQPLNKPRD------TGVACPSCGQGTFLEKKSRRGKIFYSCSNYPKCK 729 Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRD 774 E+PC K A FV + Sbjct: 730 QALWDEP--------------LEIPCPKCQAPFVTKK 752 Score = 92.5 bits (228), Expect = 7e-17, Method: Composition-based stats. Identities = 32/142 (22%), Positives = 58/142 (40%), Gaps = 18/142 (12%) Query: 703 GYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPEL 761 + C KCG+ + +K+GRFGK+ ACT ECK+T + + EV+ P+ L ++ Sbjct: 600 TTEQIDEPCPKCGAPLSIKLGRFGKFKACTGYPECKHTEPLNKEEEVSRPE---PELTDI 656 Query: 762 PCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQD 821 PC+K ++++G G + + P+ + + Sbjct: 657 PCDKCGKPMLIKEGRYGKYYGCSGAPECKNNQPLNKPRD--------------TGVACPS 702 Query: 822 PEGNKTMVRFSRKTKQQYVSSE 843 + + SR+ K Y S Sbjct: 703 CGQGTFLEKKSRRGKIFYSCSN 724 Score = 76.3 bits (186), Expect = 5e-12, Method: Composition-based stats. Identities = 26/105 (24%), Positives = 39/105 (37%), Gaps = 8/105 (7%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 ++I E +E + PC K A ++ G G F A +P+ + T Sbjct: 583 FIQQITLKDETTSKEEVTTEQIDEPCPKCGAPLSIKLGRFGKFKACTGYPECKHTEPLNK 642 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSS 842 EE + PE L D P D G +++ R K Y S Sbjct: 643 EEEVSRPE--PE----LTDIPC-DKCGKPMLIKEGRYGK-YYGCS 679 >UniRef50_Q7NGH1 DNA topoisomerase n=1 Tax=Gloeobacter violaceus RepID=Q7NGH1_GLOVI Length = 765 Score = 672 bits (1734), Expect = 0.0, Method: Composition-based stats. Identities = 299/834 (35%), Positives = 432/834 (51%), Gaps = 107/834 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+LVIVESPAKAKTI+K LG ++VVK+S GHIRDLP Sbjct: 1 MSKSLVIVESPAKAKTISKILGKNFVVKASAGHIRDLPQKE------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 MGV+ +++E Y ++P KE+VV ELK A AD +YLA D DREGEAIA Sbjct: 42 ----------MGVNVKNDFEPKYVIIPKKEEVVEELKGAARNADRVYLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ R R+ F+EITK AI+ A P +++I+RV+AQQARR +DR+VGY +S Sbjct: 92 WHLAQILDIPGDRLQRIEFHEITKQAIQNAVAHPRDIDINRVDAQQARRILDRLVGYKLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP---SGEALALQ 237 PLLWKK+ RGLSAGRVQSVAVRL+ +RE+EI+AFV EE+W V + Sbjct: 152 PLLWKKVQRGLSAGRVQSVAVRLLCDREKEIQAFVSEEYWTVHGRFRQSAQVEATPFSAD 211 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + K N+ +A V +L A V + + +P PFITSTLQ+ ++ L Sbjct: 212 LVRWSGKKPDLGNETAARAVVEVLTGAASRVDSVKTRERQKEPQPPFITSTLQREGASAL 271 Query: 298 GFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 G VK+TM +AQ+LYE G ITYMRTDST ++++A R +I +GK Y Sbjct: 272 GLTVKRTMAIAQQLYEGIDLGEEGPVGLITYMRTDSTRVAEEAQEAAREFILAAYGKSYY 331 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 P QY +K+ +Q+AHE +RP+D+N +++K + D KLY+LIW++F A QMT A Sbjct: 332 PSRRRQYGAKKGAQDAHECVRPTDINRPPDAIKKSLTPDQFKLYRLIWQRFTASQMTAAT 391 Query: 408 YDSTTLTVGAG------DFRLKARGRILRFDGWTKVMPALRKG----DEDR--ILPAVNK 455 ++ T+ + A D + FDG+T+V R+ DE+ P + + Sbjct: 392 LETRTVEIAATPTAGRPDALFRVSVTRTIFDGYTRVYEEAREEAATGDEEAAGAAPVLEE 451 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 G+ALTL+ + P QHFT+PPARFSEA+LVK LE++GIGRPSTYA I TIQ+RGYV + R Sbjct: 452 GEALTLLTVDPKQHFTQPPARFSEATLVKALEEQGIGRPSTYAPTIGTIQERGYVNKDGR 511 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 +G V D+L ++F +++ +FTA ME LD+V W +L F+ F + L Sbjct: 512 TLIPTDLGMKVNDQLVQHFPNIVDTEFTANMEAQLDEVEKGSQRWTQLLADFYGPFVETL 571 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 A+++ + +++T C +CGR + R G FLGCSGY C T Sbjct: 572 KAADEEMKRV------VIVTDHLCESCGRPLLNRYGRFGNFLGCSGYP-----ECDFTHQ 620 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE 695 L +N+ + + C +CG A + C P C + Sbjct: 621 LTRDNKPVP--------KDRPAEGISCNQCGHAPMLITYGRYGEYLKC---PACGKSQP- 668 Query: 696 EGEFRIKGYDGPIVECEKC-GSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPK 752 + C KC ++ + + GK + C +C Sbjct: 669 ---------KSTGITCPKCSKGQIVERRSKMGKNFYGCDQYPDCDFVLW----------- 708 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAG-VFLAANTFPKSRETRAPLVEELYRFRD 805 P+ + C + + + + G +A + + T AP E + Sbjct: 709 --SRPIDKPACPECGSILLYKPRKRGDDMVACSA---CKFT-APAQEMVGEEEV 756 >UniRef50_C1ABE5 DNA topoisomerase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1ABE5_GEMAT Length = 816 Score = 672 bits (1733), Expect = 0.0, Method: Composition-based stats. Identities = 280/821 (34%), Positives = 409/821 (49%), Gaps = 108/821 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G +LVIVESPAKAKTI KYLG Y VK++VGH+RDLP Sbjct: 49 GTSLVIVESPAKAKTIGKYLGRGYTVKATVGHVRDLP----------------------- 85 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++G+D H + Y + GKE ++++LK++A+ A I++ATD DREGEAI W Sbjct: 86 ------AKKLGIDIDHGFAPEYVTIEGKEDILTDLKKVAKGAREIFIATDPDREGEAIGW 139 Query: 122 HLREVIGGDDA-----RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 H+ + RV+F+EITK+A+ ++ KP +++ +V AQQARR +DR+VG Sbjct: 140 HVEQYFTQPKRHAVSAPIRRVMFHEITKDAVHKSMAKPMDIDNKKVEAQQARRVLDRLVG 199 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 Y SP+LWK + +GLSAGRVQ+VA+RL+VEREREI+AF P E+W + A + Sbjct: 200 YKASPVLWKTVKKGLSAGRVQTVALRLIVEREREIRAFTPVEYWSIAADLQK-GQQPFTA 258 Query: 237 QVTHQNDKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 ++ + K N + + ++ L + V E + + P APF TSTLQQ A+ Sbjct: 259 KLHQLDGKKPEIGNGTEAERIIADLAGRKEFVVTEVKRRERRKNPAAPFTTSTLQQEAAK 318 Query: 296 RLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 +LGFG K+TM +AQ LYE G ITYMRTDST +S+DA N R + FG Sbjct: 319 KLGFGSKRTMRLAQDLYEGIDVGIDGATGLITYMRTDSTRVSEDAANSARESLRAQFGDD 378 Query: 347 YLPESPNQYASKE-NSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMT 404 +L +P Y S + N+Q+AHE +RP+D + E ++ + AD KLYQLIW++F+A QM Sbjct: 379 FLAPAPQLYPSGKANAQDAHEGVRPTDPSRRPEQVQKFLTADQFKLYQLIWQRFMASQMA 438 Query: 405 PAKYDSTTLTVGA--------GDFRLKARGRILRFDGWTKVMPALRKG------DEDRIL 450 PA +D+TT+ ++ +A G +++F G+ + R+ ++++ L Sbjct: 439 PAVFDTTTVDFNIPIKVADAERNYLFRATGSVVKFQGFLALYREAREEGDAKALEDEQAL 498 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 P + + + + +TP QHFT+PP RFSEASLVKELE+ GIGRPSTYASIIS + +R YV Sbjct: 499 PVLEVDERVPVKAITPTQHFTEPPPRFSEASLVKELERAGIGRPSTYASIISVLVERRYV 558 Query: 511 RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 +E RRF+ +GE V + + F ++ N FTAQME LD++A E +W L F++ Sbjct: 559 SLEQRRFFPTSLGETVEKVMVKKFPDVFNVGFTAQMEEELDKIAEGEIDWVRALGDFWTP 618 Query: 571 FTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERC 630 F + L+ G + L + CP CG K+ + G F+ C + C Sbjct: 619 FQRTLND-NDLDALIGEAYDLSALETERCPDCGGKLVAKGGFFGPFVACENHPKA----C 673 Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCD 690 K T + + + A C +CG M C P C Sbjct: 674 KYTRPI------------KGEKKPAELTNYMCQECGAPMVIRH-GRSGDFLGCSKFPKCR 720 Query: 691 GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRF--GKYMACTN-EECKNTRKILRNGE 747 G V+C K G E+ + + + C N C Sbjct: 721 GTRSM----------PTGVKCPKDGGEIAERRSKKRGKAFYGCENYPNCDFVVWDKP--- 767 Query: 748 VAPPKEDPVPLPELPCEKSDA-YFVLRDGA-AGVFLAANTF 786 C + + G F Sbjct: 768 -----------VAETCPECGYVGAEAKSNKTRGSFRKCLKC 797 Score = 90.6 bits (223), Expect = 2e-16, Method: Composition-based stats. Identities = 32/175 (18%), Positives = 55/175 (31%), Gaps = 27/175 (15%) Query: 655 ALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPT-CDGYEIEEGEFRIKGYDGPIVECEK 713 + RCP CG + + C N+P C +GE + + C++ Sbjct: 639 SALETERCPDCGGKLVAK-GGFFGPFVACENHPKACKYTRPIKGEKK--PAELTNYMCQE 695 Query: 714 CGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL 772 CG+ M ++ GR G ++ C+ +C+ TR + + C K Sbjct: 696 CGAPMVIRHGRSGDFLGCSKFPKCRGTRSMP---------------TGVKCPKDGGEIAE 740 Query: 773 RDGAAG--VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGN 825 R F +P + PE A+A G+ Sbjct: 741 RRSKKRGKAFYGCENYPNCDFVVW-----DKPVAETCPECGYVGAEAKSNKTRGS 790 Score = 82.1 bits (201), Expect = 9e-14, Method: Composition-based stats. Identities = 36/139 (25%), Positives = 54/139 (38%), Gaps = 27/139 (19%) Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTNE--ECKNTRKILRNGEVAPPKEDPVPLPELPCE 764 C CG ++ K G FG ++AC N CK TR I ++ P L C+ Sbjct: 642 ETERCPDCGGKLVAKGGFFGPFVACENHPKACKYTRPIK-------GEKKPAELTNYMCQ 694 Query: 765 KSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEG 824 + A V+R G +G FL + FPK R TR+ + P+ +A+ Sbjct: 695 ECGAPMVIRHGRSGDFLGCSKFPKCRGTRS------MPTGVKCPKDGGEIAER------- 741 Query: 825 NKTMVRFSRKTKQQYVSSE 843 R ++ K Y Sbjct: 742 -----RSKKRGKAFYGCEN 755 >UniRef50_B9L7D9 DNA topoisomerase n=1 Tax=Nautilia profundicola AmH RepID=B9L7D9_NAUPA Length = 728 Score = 669 bits (1726), Expect = 0.0, Method: Composition-based stats. Identities = 286/801 (35%), Positives = 409/801 (51%), Gaps = 89/801 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKA+TI +LG +Y V +S GHIRDLP + K Sbjct: 1 MAKNLIIVESPAKARTIKNFLGKEYEVVASKGHIRDLPKTSFGIKI-------------- 46 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + Y V + + ELK+ A+KA+ IY+ATD DREGEAI Sbjct: 47 --------------EEDKFIPQYRVTADHQPIAKELKEKAKKAETIYIATDEDREGEAIG 92 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ VIG R+VF+EITK AI++A P ++++RVNAQQARR +DR+VGY +S Sbjct: 93 YHIAHVIGKKPEELPRIVFHEITKTAIKKALENPRTIDLNRVNAQQARRLLDRIVGYKLS 152 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLL KKI +GLSAGRVQS A++LVV+REREIKAF P+E+W ++ G ++ Sbjct: 153 PLLNKKIQKGLSAGRVQSAALKLVVDREREIKAFKPQEYWSIEGIFKKIEGS--LIKYNG 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + F +K++ Q V L+ Y+V E E K TT K APF+TSTLQQ AS+ LGF Sbjct: 211 KKLDKFDIKSKDEAQKIVEELKPLEYTVREIETKTTTVKSPAPFMTSTLQQVASSELGFS 270 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 +KTM +AQ+LYE G ITYMRTDS N++++A +I N G++Y Sbjct: 271 PRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQQAALEFIKQNIGEEYAQAKT 330 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 +N+QEAHEAIRP DV + + LK+ ++ D KLY LI+ +F+A QM AK+++ Sbjct: 331 YA-TKNQNAQEAHEAIRPVDVRLTPDDLKNYLKPDELKLYALIFNRFLASQMKDAKFETQ 389 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + + K GR L FDG+ KV K + +LP KG+ L ++ QHFT Sbjct: 390 NIYIANDKGEFKISGRKLIFDGFYKVYG---KPSANTLLPEFEKGEKLKPEDVKATQHFT 446 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPP R++EASL+K+LE GIGRPSTYA I+ +Q+R YV V++++ + ++ V + LE Sbjct: 447 KPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEVKDKKLHPTEIAFSVIETLE 506 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 ++F ++++ +FTA ME LD+VA + +W+ VL F++ F + ++K K+ Sbjct: 507 KHFPDIVDANFTANMEEMLDEVAEAKKDWQEVLKDFYNPFMELVNKGYKEI----PSQKI 562 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 CP CG + IR G F+ CS Y +CK T L E Sbjct: 563 AKPIDETCPLCGSPLVIRKGRFGEFIACSSYP-----KCKYTRPLEESKEEKK------- 610 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVEC 711 +C KCG M + C N P C + V+C Sbjct: 611 ------TDVKCDKCGADMVVKK-GKSGEFLACSNYPKCKNTKPLNA-----PEVLDDVKC 658 Query: 712 EKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYF 770 +CG ++ + R G++ C N +C K C + Sbjct: 659 PECGGDIVKRKSRRGEFYGCANYPKCNFISKYRP--------------VNKKCPECGYLM 704 Query: 771 VLRDGAAGVFLAANTFPKSRE 791 R K + Sbjct: 705 AERTYRKKDVYEC---IKCKH 722 Score = 65.5 bits (158), Expect = 8e-09, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 34/100 (34%), Gaps = 13/100 (13%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRF 803 G P + + C + V+R G G F+A +++PK + TR EE Sbjct: 551 NKGYKEIPSQKIAKPIDETCPLCGSPLVIRKGRFGEFIACSSYPKCKYTRPL--EESKEE 608 Query: 804 RDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 + + D G +V+ + + S Sbjct: 609 KKT----------DVKCDKCGADMVVKKGKSG-EFLACSN 637 >UniRef50_C0QYG0 DNA topoisomerase n=2 Tax=Brachyspira RepID=C0QYG0_BRAHW Length = 716 Score = 669 bits (1725), Expect = 0.0, Method: Composition-based stats. Identities = 283/756 (37%), Positives = 411/756 (54%), Gaps = 80/756 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 LVIVESPAKAKTIN+YLGSDY+V SS+GH+ DLP Sbjct: 28 LVIVESPAKAKTINRYLGSDYLVMSSMGHLIDLP-------------------------- 61 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +R+ +D H +E Y + G+ K+++ELK+ A+KA+ + LA D DREGE+IAWH+ Sbjct: 62 ---RSRLAIDVDHGFEPEYITIRGRAKILNELKKEAKKAEEVLLAADDDREGESIAWHIG 118 Query: 125 EVIGGDDA--RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 I G ++ R+VF+EITK+A+++A ++P +++I +VNAQ+ARR +DR++GY +SPL Sbjct: 119 NKIRGVNSAVPIKRIVFHEITKDALKEAIDQPRDIDISKVNAQKARRVLDRLIGYNLSPL 178 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LW KI RGLSAGRVQ+VA+ ++ RE EI+ FVP E+W + E L ++ Sbjct: 179 LWDKIKRGLSAGRVQNVALLIICNREDEIETFVPVEYWTFGVFLKHKNKEFL-AELQKYK 237 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 + K+ + + L+ Y+V E K P AP+ TS LQQAAS+ LG+ Sbjct: 238 GEKPDLKTKQDVEDIMEHLKDKTYTVASIEVKDRLRNPTAPYTTSKLQQAASSALGYSAS 297 Query: 303 KTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 KTM +AQ LYE G ITYMRTDS +S A + +I +G YLP P Sbjct: 298 KTMQVAQSLYEGVDIAGEATGLITYMRTDSVRISPVAQEQAKEFIEKEYGSNYLPPEPPT 357 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 Y+ K+N+Q+AHEAIRP+++ + +S+K+ ++ D KLY+LIW +FV+ QM PAK +T Sbjct: 358 YSVKKNAQDAHEAIRPTNIFLTPDSIKEYLKTDQYKLYKLIWERFVSSQMLPAKMKNTRA 417 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDED-RILPAVNKGDALTLVELTPAQHFTK 472 + AGD + FDG+ KV+ ++ E +P ++K D VE P QHFT Sbjct: 418 IIVAGDCEFSLSSSKIEFDGFMKVLTIDKEDKEKASKMPNLSKDDVCEFVENNPQQHFTT 477 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PP R+++ASLVK LE+ GIGRPSTYA I TI R YV+ + ++ ++G++V + + E Sbjct: 478 PPPRYTDASLVKILEESGIGRPSTYAPTIKTIISRHYVQRKGKQLVPTELGKLVNELISE 537 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 NF EL+N +FTA ME+ LD++ + EW +L F+ F L A ++ M+ Sbjct: 538 NFPELVNINFTADMESKLDKIEDDNIEWNNILKEFYPHFLDTLKTATENI--NNMKDFFN 595 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 T C CG+KM R G F+ CSG+ CK T + Sbjct: 596 EETDFVCEKCGKKMIKRLGRYGYFIACSGFP-----ECKNTKGI---------------- 634 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 + CPKCG + R+ + C N P CD ++ C Sbjct: 635 -----SFGVCPKCGGDITLKRSKRGREFYGCSNYPKCDFVSWDKPLQEP---------CP 680 Query: 713 KCGSEMHLKMGR-FGKYMACTNEECKNTRKILRNGE 747 KCG M K + G + C E+C + +I + E Sbjct: 681 KCGGLMVEKNIKNKGLFKVCIKEDCGYSEEIKEDEE 716 Score = 74.4 bits (181), Expect = 2e-11, Method: Composition-based stats. Identities = 26/172 (15%), Positives = 44/172 (25%), Gaps = 30/172 (17%) Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCD 690 + + + + + C KCG M L C P C Sbjct: 571 EFYPHFLDTLKTATENINNMKDFFNEETDFVCEKCGKKMIKRL-GRYGYFIACSGFPECK 629 Query: 691 GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEV 748 C KCG ++ LK + G+ + C+N +C Sbjct: 630 N-----------TKGISFGVCPKCGGDITLKRSKRGREFYGCSNYPKCDFVSWDKP---- 674 Query: 749 APPKEDPVPLPELPCEKSDAYFVLRDGA-AGVFLAANTFPKSRETRAPLVEE 799 + PC K V ++ G+F + +E Sbjct: 675 ----------LQEPCPKCGGLMVEKNIKNKGLFKVCIK-EDCGYSEEIKEDE 715 Score = 74.0 bits (180), Expect = 3e-11, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 42/122 (34%), Gaps = 23/122 (18%) Query: 697 GEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDP 755 + + CEKCG +M ++GR+G ++AC+ ECK + Sbjct: 588 NNMKDFFNEETDFVCEKCGKKMIKRLGRYGYFIACSGFPECK----------------NT 631 Query: 756 VPLPELPCEKSDAYFVLRDGAAGV-FLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYL 814 + C K L+ G F + +PK V ++ P+ + Sbjct: 632 KGISFGVCPKCGGDITLKRSKRGREFYGCSNYPKCDF-----VSWDKPLQEPCPKCGGLM 686 Query: 815 AD 816 + Sbjct: 687 VE 688 Score = 57.4 bits (137), Expect = 3e-06, Method: Composition-based stats. Identities = 16/99 (16%), Positives = 31/99 (31%), Gaps = 20/99 (20%) Query: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFR 804 + K+ + CEK + R G G F+A + FP+ + T+ Sbjct: 584 TENINNMKDFFNEETDFVCEKCGKKMIKRLGRYGYFIACSGFPECKNTKGI--------- 634 Query: 805 DRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 G ++ S++ ++ Y S Sbjct: 635 -----------SFGVCPKCGGDITLKRSKRGREFYGCSN 662 >UniRef50_A9FRC6 DNA topoisomerase I n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9FRC6_SORC5 Length = 864 Score = 667 bits (1722), Expect = 0.0, Method: Composition-based stats. Identities = 305/870 (35%), Positives = 419/870 (48%), Gaps = 145/870 (16%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI KYLG+ Y V +S GH++DLP + Sbjct: 1 MAKTLVIVESPAKAKTIKKYLGNGYEVFASKGHVKDLPKKQN------------------ 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VD +++ YEV+ GKEKV+ ELK A+KAD + LATD DREGEAIA Sbjct: 43 -----------AVDVQNDFAETYEVIEGKEKVLEELKSAAKKADEVLLATDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ E I + +RV F+EITK + + P +L+ + +AQ+ARR +DR+VGY VS Sbjct: 92 FHISEEIKNPKLKVARVEFHEITKKGVDHGVHNPRKLDENLYDAQRARRVLDRIVGYDVS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT---PSGEALALQ 237 L+W K+A GLSAGRVQSVA+RL+V+RERE++AFVPEE+W + P + Sbjct: 152 ALVWSKLAFGLSAGRVQSVALRLIVDREREVEAFVPEEYWNIAVGLGAASPPQRAPFVAK 211 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + K N E + LE ARY V + + P AP+ TS LQQ A+ L Sbjct: 212 LASADGKKLEVTNGEVAGKVRADLETARYRVAKVVRREQKRNPPAPYTTSKLQQDATNYL 271 Query: 298 GFGVKKTMMMAQRLYEA----------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 FG K+TM +AQ LYE G ITYMRTDST +S DAV VRG ++ +GK++ Sbjct: 272 HFGAKRTMQIAQALYEGIDLKRDGGPVGLITYMRTDSTRVSDDAVAEVRGVVAKRYGKEF 331 Query: 348 LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPA 406 +PE PN + SK+N+Q+AHEAIRP+ V + +S+K ++ + KLY+LIW +FVA QMTPA Sbjct: 332 VPERPNVFKSKKNAQDAHEAIRPTSVEIHPDSIKKHLKDEQYKLYKLIWNRFVASQMTPA 391 Query: 407 KYDSTTLTVGAGD---------FRLKARGRILRFDGWTKVMP------------------ 439 YD TT+ + + +A GRIL+F GW +V Sbjct: 392 VYDRTTVEIDVAPTLAAPAYRSYLARATGRILKFAGWLQVTEGQQEFAGEEESAGAAADG 451 Query: 440 --------------------ALRKGDEDRILPAVNKGDALTLV--ELTPAQHFTKPPARF 477 + D + +LP + +G+AL++ + Q FT+PP R+ Sbjct: 452 GAAAPAPEATAAEAERAAPGPSAEEDSEALLPDMKEGEALSVSPPGVITDQKFTQPPPRY 511 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYVR-VENRRFYAEKMGEIVTDRLEENFRE 536 +E SLV+ELEKRGIGRPSTYA IIS +Q R YV + F +G+ V D L + + Sbjct: 512 NEGSLVRELEKRGIGRPSTYAEIISKVQQRAYVEKRDGGAFQPTLLGKFVVDGLVRSNLD 571 Query: 537 LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTS 596 +M+ +FTAQME LD V + + +L F+ F +QLDK++K + T Sbjct: 572 IMDPNFTAQMEEELDAVGAGSLKREQLLKSFYKKFREQLDKSKKLAPW----KPEAEKTD 627 Query: 597 IDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNAL 656 I C CG M + G FL C Y +CK T +L V E Sbjct: 628 IVCDECGSMMLKKWGKNGWFLSCERYP-----KCKATRDLSDARGTAAVRE--------- 673 Query: 657 RAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGS 716 C KCG M C P C V C CG Sbjct: 674 -TDISCDKCGKPMIIK-TGRFGDFLSCTGYPACKNTRP----------VPLGVACPSCGG 721 Query: 717 EMHLKMGRFG---KYMACTNE----ECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 ++ R + C+N +C+ +PC + A Sbjct: 722 DLIEIRPRKKGGRTFYGCSNWNAEQKCEFKLWQKP--------------VPVPCPQCGAK 767 Query: 770 FVLRDGAAGVFLAANTFPKSRETRAPLVEE 799 FV R L T + + E Sbjct: 768 FVTRTAGKKAMLVCAT-KDCGFKQEIVEGE 796 Score = 64.4 bits (155), Expect = 2e-08, Method: Composition-based stats. Identities = 16/99 (16%), Positives = 32/99 (32%), Gaps = 9/99 (9%) Query: 737 KNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPL 796 K R+ L + P + ++ C++ + + + G G FL+ +PK + TR Sbjct: 604 KKFREQLDKSKKLAPWKPEAEKTDIVCDECGSMMLKKWGKNGWFLSCERYPKCKATRDLS 663 Query: 797 VEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKT 835 D G +++ R Sbjct: 664 DARGTA---------AVRETDISCDKCGKPMIIKTGRFG 693 >UniRef50_Q5SM69 DNA topoisomerase n=2 Tax=Thermus thermophilus RepID=Q5SM69_THET8 Length = 830 Score = 667 bits (1721), Expect = 0.0, Method: Composition-based stats. Identities = 289/831 (34%), Positives = 399/831 (48%), Gaps = 120/831 (14%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LV+VESPAKA++I K LG Y V++S+GH+ DLP Sbjct: 17 TLVVVESPAKARSIQKMLGPGYEVRASLGHVVDLPERS---------------------- 54 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +GVD ++ YEV K+ VV ELK+ AE + +ATD DREGEAI WH+ Sbjct: 55 -------LGVDVERDFAPTYEVKKDKKPVVEELKRAAEG-KRLLIATDPDREGEAIGWHV 106 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 ++G D RV F+EIT +RQA P ++ + V+AQQARR +DR++GY +SPLL Sbjct: 107 ARLLGRDPKEPLRVEFHEITPRVVRQAVEAPRPIDQNLVDAQQARRVLDRLLGYNLSPLL 166 Query: 184 WKKI-ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL------ 236 + R LSAGRVQSVA+RLVVERE I+AF PEE+W + GEA + Sbjct: 167 SLEFRKRALSAGRVQSVALRLVVEREEAIEAFRPEEYWVLRGVFAVEGGEAPLVATLHEV 226 Query: 237 ----QVTHQNDKPFRP--VNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 T Q +K R ++ + A L K Y V + E + P PF TSTLQ Sbjct: 227 EGKRLWTGQGEKEGRLHLASEAEAHALAEALRKGSYRVAQVEVRERRKAPPPPFTTSTLQ 286 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 QAAS+RLG+ +TM +AQRLYE G ITYMRTDS ++ +AV R I Sbjct: 287 QAASSRLGYTAARTMRIAQRLYEGVDLPEGTVGLITYMRTDSVRVAPEAVAAAREVIGKA 346 Query: 343 FGKKYLPESPNQYASKE-NSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVA 400 FG +YLPE+P Y ++ Q+AHEAIRP+D ES++ + + +LY+LIWR+F+A Sbjct: 347 FGPEYLPEAPRAYKNRREGVQDAHEAIRPTDPKRTPESVRPYLSEEEYRLYELIWRRFLA 406 Query: 401 CQMTPAKYDSTTLTVGA--GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 QM A Y+ T +T+ G + +A G +LRF+G+ + + +E+ +PAV +G Sbjct: 407 SQMRDALYEQTAVTLADLEGRYAFRASGSVLRFEGYLRAWGRDAEEEEEPPVPAVPEGVP 466 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFY 518 L E+ + FT+PP R+++ASLVK +E+ GIGRPSTYA + T++ RGYV + R + Sbjct: 467 ARLEEVLEERRFTEPPPRYTDASLVKTMEELGIGRPSTYAPTLETLEKRGYVARKGRTLF 526 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 +G VT L E F +++ Y+FTA+ME LD+V W V+ F+ F +L + Sbjct: 527 PTPLGRQVTAYLRERFPQVVAYEFTARMEERLDEVEEGRVPWPKVVWEFYEPFLGELAQV 586 Query: 579 EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVP 638 K CP CGR + ++ + G FLGC+GY C T L Sbjct: 587 PKK----------------TCPRCGRPLELKVSRYGQFLGCTGYP-----ECTYTEPLER 625 Query: 639 ENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGE 698 A CPKCG + C P CD + Sbjct: 626 RE--------------AEPIGEACPKCGRPLLRKE-GRYGTFIACSGYPECDYTRDD--- 667 Query: 699 FRIKGYDGPIVECEKCGSEMHLKMGRFG-KYMACTNEECKNTRKILRNGEVAPPKEDPVP 757 C KCG + K R G Y C N C P Sbjct: 668 -----GTPTGHTCPKCGGRVLEKRSRKGRPYYKCENNACDFL--------------SFYP 708 Query: 758 LPELPCEKSDAYFVLRDGAAGVFLAANT--FPKSRETRAPLVEELYRFRDR 806 L E C V G P+ + P +E + R R Sbjct: 709 LLEEACPACGWPLV----KKGEKALCLNPACPEHEPSLLPAPKEAKKGRSR 755 Score = 94.4 bits (233), Expect = 2e-17, Method: Composition-based stats. Identities = 39/204 (19%), Positives = 60/204 (29%), Gaps = 35/204 (17%) Query: 638 PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEG 697 P +V+ A K+ CP+CG ++ + + C P C E E Sbjct: 567 PWPKVVWEFYEPFLGELAQVPKKTCPRCGRPLE-LKVSRYGQFLGCTGYPECTYTEPLER 625 Query: 698 EFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPV 756 + C KCG + K GR+G ++AC+ EC TR D Sbjct: 626 REA----EPIGEACPKCGRPLLRKEGRYGTFIACSGYPECDYTR-------------DDG 668 Query: 757 PLPELPCEKSDAYFVLRDGAAG-VFLAANT---------------FPKSRETRAPLVEEL 800 C K + + G + P E+ Sbjct: 669 TPTGHTCPKCGGRVLEKRSRKGRPYYKCENNACDFLSFYPLLEEACPACGWPLVKKGEKA 728 Query: 801 YRFRDRLPEKLRYLADAPQQDPEG 824 PE L AP++ +G Sbjct: 729 LCLNPACPEHEPSLLPAPKEAKKG 752 Score = 64.0 bits (154), Expect = 3e-08, Method: Composition-based stats. Identities = 18/117 (15%), Positives = 36/117 (30%), Gaps = 24/117 (20%) Query: 757 PLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLAD 816 +P+ C + L+ G FL +P+ T E + P+ Sbjct: 585 QVPKKTCPRCGRPLELKVSRYGQFLGCTGYPECTYTEPLERREAEPIGEACPK------- 637 Query: 817 APQQDPEGNKTMVRFSRKTKQQYVS---------SEKDGKATGWSAFYVDGKWVEGK 864 G + + R +++ + DG TG + G+ +E + Sbjct: 638 ------CGRPLLRKEGRYG--TFIACSGYPECDYTRDDGTPTGHTCPKCGGRVLEKR 686 >UniRef50_B1GYR4 DNA topoisomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=B1GYR4_UNCTG Length = 740 Score = 665 bits (1715), Expect = 0.0, Method: Composition-based stats. Identities = 308/785 (39%), Positives = 436/785 (55%), Gaps = 66/785 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP K KTI+K LG D+ VKSS GHIRDLP Sbjct: 1 MSKYLVIVESPTKEKTISKILGKDFTVKSSYGHIRDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 N++G+D N++ Y+ + +K++S+LK+ AE +D IYLATD DREGEAIA Sbjct: 39 -------KNKLGIDIEDNFKPTYKNISKSKKLISDLKKKAENSDKIYLATDFDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+E + +++ SR+ F+EIT AI +A P L++ VN+QQARR +DR+VGY +S Sbjct: 92 WHLKEALKLPESKISRITFHEITTEAILKAVKHPRNLDMKLVNSQQARRILDRLVGYKLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT--PSGEALALQV 238 PLLWKK+ GLSAGRVQSVAV L+ +RE E K+F+P E+W ++A + + + Sbjct: 152 PLLWKKVKPGLSAGRVQSVAVMLICKREEEFKSFIPVEYWSIEAELSKLEENTTPFKSLL 211 Query: 239 THQNDKPFR---PVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 +ND F NKEQ+ + LE A+Y V E K P AP+ TST+QQ AS Sbjct: 212 FSKNDVKFDKLSVKNKEQSDETLKELEGAKYIVKSVETKQRKRSPYAPYTTSTMQQDASR 271 Query: 296 RLGFGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 +LGF KTM AQ+LYE AG ITYMRTDS N+++ + +I ++G Sbjct: 272 KLGFSASKTMSAAQKLYEGVHIGNSTNAGLITYMRTDSLNIAKSVQSETLKFIEYSYGSN 331 Query: 347 YLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMT 404 +LP+ P Y +K + +QEAHEAIRP N + +K + D KLY LIW++F+A QM Sbjct: 332 FLPKIPRIYKTKTKGAQEAHEAIRPISPNRIPSEVKQYLSEDELKLYNLIWKRFLASQMA 391 Query: 405 PAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 464 A Y++ T + A D+ K+ L FDG+ KV A E + LP++ G+ L L+ L Sbjct: 392 DAVYNTVTAEILAKDYLFKSLESTLIFDGFLKVYNADDDEKETKKLPSLKSGEQLNLLRL 451 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGE 524 P QHFT+PP + ASL+K LE+ GIGRPSTYA I TI DR YV ++ ++F G Sbjct: 452 LPLQHFTEPPPLYDVASLIKALEEHGIGRPSTYAPTIKTILDRLYVHLDGKKFVPTNRGI 511 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 +V + L+++F ++N +FTA +E LD++A +A W+ VL F+ F + L +AEK+ ++ Sbjct: 512 VVNNVLKDHFGNIINVEFTASVEEKLDKIAEDKAVWQNVLKDFYKPFKKDLSEAEKNLQK 571 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 ++ Q TS CP CG+ M IR + FLGCSGY CKTT++L + ++ Sbjct: 572 QKVQAQQ---TSEICPNCGKNMVIRYSRKVQFLGCSGYP-----ECKTTLSLDKDGKIAA 623 Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 +C KCG+ + ++ C N P C + Y Sbjct: 624 APR---------ETDMKCDKCGSHLIKKTGFAGKQYLSCKNYPECKTLYNINKDGNKIIY 674 Query: 705 DGPIV---ECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPE 760 P +C KCGSEM K+G+ G ++ C+ +C+N + I N V L E Sbjct: 675 PEPEHTDIKCNKCGSEMLKKIGKRGPFLTCSAFPKCRNLQWIKTNKTPKSKTYKTVKLSE 734 Query: 761 LPCEK 765 K Sbjct: 735 KKTTK 739 Score = 99.0 bits (245), Expect = 7e-19, Method: Composition-based stats. Identities = 41/185 (22%), Positives = 67/185 (36%), Gaps = 6/185 (3%) Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCD 690 K ++ + + A + CP CG M + C P C Sbjct: 552 KDFYKPFKKDLSEAEKNLQKQKVQAQQTSEICPNCGKNMVIRYSRKV-QFLGCSGYPECK 610 Query: 691 GYEIEEGEFRIKGYDGPIV-ECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGE 747 + + +I +C+KCGS + K G GK Y++C N ECK I ++G Sbjct: 611 TTLSLDKDGKIAAAPRETDMKCDKCGSHLIKKTGFAGKQYLSCKNYPECKTLYNINKDGN 670 Query: 748 VAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRL 807 E ++ C K + + + G G FL + FPK R + + + + Sbjct: 671 KIIYPEP--EHTDIKCNKCGSEMLKKIGKRGPFLTCSAFPKCRNLQWIKTNKTPKSKTYK 728 Query: 808 PEKLR 812 KL Sbjct: 729 TVKLS 733 Score = 64.7 bits (156), Expect = 1e-08, Method: Composition-based stats. Identities = 12/106 (11%), Positives = 28/106 (26%), Gaps = 8/106 (7%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 + + + ++ C V+R FL + +P+ + T + Sbjct: 558 FKKDLSEAEKNLQKQKVQAQQTSEICPNCGKNMVIRYSRKVQFLGCSGYPECKTTLSLDK 617 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 + R + D G+ + + KQ Sbjct: 618 DGKIAAAPR--------ETDMKCDKCGSHLIKKTGFAGKQYLSCKN 655 >UniRef50_B5YFC7 DNA topoisomerase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YFC7_DICT6 Length = 694 Score = 664 bits (1714), Expect = 0.0, Method: Composition-based stats. Identities = 276/765 (36%), Positives = 403/765 (52%), Gaps = 84/765 (10%) Query: 1 MGK-ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKP 59 M K L+IVESPAKAKTI K LG D+ V +S GHIRDLP Sbjct: 1 MSKEKLIIVESPAKAKTIEKILGKDFKVLASYGHIRDLPEKE------------------ 42 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 +GVD + ++ Y +LP ++K++ +K L++K + +YLATD DREGEAI Sbjct: 43 -----------LGVDIENGFKPKYVLLPSRKKIIDTIKDLSKKVEKLYLATDPDREGEAI 91 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 AWHL E + +++R+ F+EIT AI++A P ++++D+V AQQARR +DR+VGY + Sbjct: 92 AWHLVETLKLPKDKFTRIEFHEITPRAIQEAIRNPRDIDLDKVEAQQARRILDRLVGYEL 151 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SPLLW+K+ RGLSAGRVQSVA++L+ ERE EI+ FVPEE+W + + + ++ Sbjct: 152 SPLLWEKVRRGLSAGRVQSVALKLICEREEEIEKFVPEEYWYIYGEFEDKD-KIIYGKLV 210 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 ++ N+++ + + +L Y + K P PFITSTLQQ AS RLGF Sbjct: 211 FYKEEEITIRNEKEAKRLIEVLNNLEYKIDRVVIKEEKKTPPLPFITSTLQQEASRRLGF 270 Query: 300 GVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 V KTM +AQ LYE G ITYMRTDST ++ +A YI FGK+Y+ + Sbjct: 271 PVSKTMKIAQSLYEGVDIGDERVGLITYMRTDSTRIAPEAREEAVTYIESVFGKEYVGKE 330 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 + K Q+AHEAIRP+ V E +K + D KLY+LIW +F+A QM A YD Sbjct: 331 RKERK-KLGMQDAHEAIRPTSVLRTPEKVKKYLTEDQYKLYKLIWERFLASQMANALYDV 389 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAV--NKGDALTLVELTPAQ 468 + + GD+ ++GR L+F G+ + + +E+ + +G + L+ LTP Q Sbjct: 390 IEIDIKGGDYTFVSKGRKLKFAGFMSLYTEKEEEEEEEVNVDYIPQEGSDIDLINLTPKQ 449 Query: 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528 FT+PP R++EA+LV+ LEK GIGRPSTYA+II T+++R YV V + +G++V + Sbjct: 450 FFTQPPPRYTEATLVRTLEKYGIGRPSTYATIIETLKERKYVEVSKKELVPTTLGKVVNE 509 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 L + F L++ FTA+ME LD++ + E + VL+ F+ F ++L++ K + Sbjct: 510 FLTKQFPHLIDVKFTAKMEEDLDKIESGEVKAIEVLEKFYPSFKEELERVSK----NFGK 565 Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 + T CP CGR++ IR G + CS Y CK T + E Sbjct: 566 IQVVEKTDEFCPICGRELVIRENKHGKYYACSAYP-----ECKYTKPIYEE--------- 611 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDP-KRKLHVCGNNPTCDGYEIEEGEFRIKGYDGP 707 A +CP CG + + C N P C E Sbjct: 612 ---------AHGKCPLCGGIVVKKKARKTGKVFWGCINYPNCSFASPYE---------PL 653 Query: 708 IVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 +C +CGS + G + C+NE C + R K Sbjct: 654 DEKCPQCGSVLLKGNG----FKKCSNENCNYIVWVGRRKRWKKSK 694 Score = 65.1 bits (157), Expect = 1e-08, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 37/122 (30%), Gaps = 21/122 (17%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKED 754 + +I+ + C CG E+ ++ + GKY AC+ ECK T+ I Sbjct: 561 KNFGKIQVVEKTDEFCPICGRELVIRENKHGKYYACSAYPECKYTKPIYEEA-------- 612 Query: 755 PVPLPELPCEKSDAYFVLRDGAA--GVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLR 812 C V + VF +P ++ P+ Sbjct: 613 -----HGKCPLCGGIVVKKKARKTGKVFWGCINYPNCSFASP-----YEPLDEKCPQCGS 662 Query: 813 YL 814 L Sbjct: 663 VL 664 Score = 58.2 bits (139), Expect = 1e-06, Method: Composition-based stats. Identities = 10/61 (16%), Positives = 20/61 (32%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRF 803 K V + C V+R+ G + A + +P+ + T+ E + Sbjct: 557 ERVSKNFGKIQVVEKTDEFCPICGRELVIRENKHGKYYACSAYPECKYTKPIYEEAHGKC 616 Query: 804 R 804 Sbjct: 617 P 617 >UniRef50_D1B6D6 DNA topoisomerase I n=3 Tax=Synergistaceae RepID=D1B6D6_THEAS Length = 708 Score = 663 bits (1710), Expect = 0.0, Method: Composition-based stats. Identities = 267/713 (37%), Positives = 387/713 (54%), Gaps = 74/713 (10%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LV+VESP KAK+++K LG Y V++S+GH+ DLP Sbjct: 44 TLVVVESPTKAKSLSKMLGPGYAVEASLGHVMDLPKV----------------------- 80 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 R+GVD + +E Y + GK V+ LK+LA A + LA+D DREGEAIAWHL Sbjct: 81 ------RLGVDVENGFEPEYIQVRGKGPVIKRLKELARGASRVLLASDPDREGEAIAWHL 134 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 ++G RV +EIT + I A + +++++V AQQARR +DR+VGY +SPLL Sbjct: 135 ATLLGVPLDSPCRVRIHEITPSGISAALQEVEGIDMNKVYAQQARRVLDRLVGYRLSPLL 194 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 W K+ RGLSAGRVQSVA+RLV ERE EI +FVPEE+W V+ G + L++ + Sbjct: 195 WAKVQRGLSAGRVQSVALRLVCEREDEIDSFVPEEYWLVEVQAEAEGGRSYLLKLDKEAG 254 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 KP R ++ + +L+ + V + +P PF TSTLQQ AS RLG+G ++ Sbjct: 255 KPVRLKDQADARRVEALVRSSPLQVSSFRSRDGLRRPMPPFKTSTLQQEASRRLGYGPRR 314 Query: 304 TMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 TM +AQ L+E G ITYMRTDS +S +A++ +RG+I+ FG YLPE PN Sbjct: 315 TMRIAQSLFEGVEIPGRGPVGLITYMRTDSLRISDEAISAMRGHIASRFGPMYLPERPNH 374 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 +A K SQ+AHEAIRP+DV + +++++ + ++ +LY LIWR+ +A QM A+ + TL Sbjct: 375 FAQKGRSQDAHEAIRPTDVTLEPDAIREYLSSEQYRLYDLIWRRALASQMADARVRTNTL 434 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKP 473 G+ K G + F GW V P K E +PA ++G+ L +++ Q FT+P Sbjct: 435 EARCGELTFKCSGVEVTFQGWGAVWPLGVKDTE---VPAASEGEDLRPLQVRLEQKFTQP 491 Query: 474 PARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRLEE 532 P R++EA L+K LE++GIGRPSTYA+I+ T+ DRGYV ++++ K+G +V L Sbjct: 492 PGRYTEAGLIKALEEKGIGRPSTYATIVETLSDRGYVVRDDDKKLSPTKLGRVVNAFLVT 551 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 +F +++ DFTA+ME+ LD+V + E +W+ + F+ F +L + + + P Sbjct: 552 HFPDVVQVDFTARMEDQLDRVESGEIQWREPIGDFYGPFESRLQEVAASAQRMTVPP--- 608 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 L DCP CGR + IR G F+GCSGY C T Sbjct: 609 ELAGEDCPQCGRPLLIRRGRYGEFIGCSGYP-----ECDFTKRKETS------------- 650 Query: 653 TNALRAKRRCPKCGTAMD-----SYLIDPKRKLHVCGNNPTCDGYEIEEGEFR 700 CPKCG S R + C P CD + + Sbjct: 651 -----TGVPCPKCGQGTVVARKASKGKGKGRTFYGCSRYPECDYVSWSKPKGD 698 Score = 74.8 bits (182), Expect = 2e-11, Method: Composition-based stats. Identities = 19/114 (16%), Positives = 38/114 (33%), Gaps = 20/114 (17%) Query: 703 GYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPEL 761 + +C +CG + ++ GR+G+++ C+ EC T + + Sbjct: 607 PPELAGEDCPQCGRPLLIRRGRYGEFIGCSGYPECDFT-------------KRKETSTGV 653 Query: 762 PCEKSD-AYFVLRDGAAGV-----FLAANTFPKSRETRAPLVEELYRFRDRLPE 809 PC K V R + G F + +P+ + + E Sbjct: 654 PCPKCGQGTVVARKASKGKGKGRTFYGCSRYPECDYVSWSKPKGDGTVSEVRDE 707 Score = 62.4 bits (150), Expect = 8e-08, Method: Composition-based stats. Identities = 32/231 (13%), Positives = 60/231 (25%), Gaps = 14/231 (6%) Query: 618 GCSGYALPPKERCKTTIN--LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLID 675 G L + K T E ++ LE + + A D Sbjct: 474 GEDLRPLQVRLEQKFTQPPGRYTEAGLIKALEEKGIGRPSTYATIVETLSDRGYVVRDDD 533 Query: 676 PKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEE 735 K G ++ + ++ S G + Sbjct: 534 KKLSPTKLGRVVNAFLVTHFPDVVQVDFTARMEDQLDRVESGEIQWREPIGDFYG----- 588 Query: 736 CKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAP 795 ++ A P L C + ++R G G F+ + +P+ T+ Sbjct: 589 -PFESRLQEVAASAQRMTVPPELAGEDCPQCGRPLLIRRGRYGEFIGCSGYPECDFTK-- 645 Query: 796 LVEELYRFRDRLPEKLR--YLADAPQQDPEGNKTMVRFSRKTKQQYVSSEK 844 + P+ + +A + +T SR + YVS K Sbjct: 646 --RKETSTGVPCPKCGQGTVVARKASKGKGKGRTFYGCSRYPECDYVSWSK 694 Score = 61.7 bits (148), Expect = 1e-07, Method: Composition-based stats. Identities = 20/103 (19%), Positives = 30/103 (29%), Gaps = 16/103 (15%) Query: 654 NALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEK 713 A CP+CG + + C P CD + + V C K Sbjct: 607 PPELAGEDCPQCGRPLLIRR-GRYGEFIGCSGYPECDFTK--------RKETSTGVPCPK 657 Query: 714 CG-SEMHLKMGRFGK-----YMACTN-EECKNTRKILRNGEVA 749 CG + + GK + C+ EC G+ Sbjct: 658 CGQGTVVARKASKGKGKGRTFYGCSRYPECDYVSWSKPKGDGT 700 >UniRef50_B5YKX8 DNA topoisomerase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=B5YKX8_THEYD Length = 777 Score = 663 bits (1710), Expect = 0.0, Method: Composition-based stats. Identities = 297/865 (34%), Positives = 447/865 (51%), Gaps = 121/865 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L+IVESPAKAKTINK +G D+ VK+S+GHI+DLP Sbjct: 5 GKNLIIVESPAKAKTINKIVGKDFQVKASIGHIKDLPE---------------------- 42 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +R+GVD ++ Y ++PGKEK+V ELK A+ A I++ATD DREGEAIA+ Sbjct: 43 -------DRLGVDIEKGFQPDYIIIPGKEKIVKELKDSAKNAQKIFIATDPDREGEAIAY 95 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ E I + + R +F+EIT NA++ A P +++I++V +QQARR +DR+VGY +SP Sbjct: 96 HIAEEIKVPENKVYRAIFHEITPNAVKAAIANPSKIDINKVYSQQARRILDRLVGYNLSP 155 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG---------- 231 LWKK+ +GLSAGRVQSVA+R+VVERE+EI F PE +W + + Sbjct: 156 FLWKKVKKGLSAGRVQSVALRMVVEREKEILIFQPENYWTIVGNFKNDENLKELRANLYK 215 Query: 232 -EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQ 290 + + + F ++E Q + L+K Y + + E K P PF T+TLQ Sbjct: 216 YKGKLIIDRKEEKAKFLITDEETAQKIIEELKKLNYILTKVEKKKKKKNPPEPFRTATLQ 275 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 AS+ LGF KKTMM+AQ+LYE G ITYMRTDST ++++A + I N Sbjct: 276 AQASSTLGFSPKKTMMLAQQLYEGIDIEGTRIGLITYMRTDSTRVAEEAKKWAKNIIEKN 335 Query: 343 FGKKYLPESPNQYASKENS--QEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFV 399 FGK+++ K+ + Q+AHE IRP+ + ES+K + + LY+LIW +F+ Sbjct: 336 FGKEFVGNHKIHETKKQKTPIQDAHECIRPTYPDKSPESIKKYLTKEQYSLYKLIWDRFL 395 Query: 400 ACQMTPAKYDSTTLTVGAGD--FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 A QM+PA+ + TT + D + + G ++ F G+ + + +ED +LP +N+ Sbjct: 396 ASQMSPAEVEQTTYIIEDLDSIAQFRVTGSVITFPGFLIIYK-DEESEEDTVLPQLNEKT 454 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 +L + EL +H T+PP R++EA+LVK LE++GIGRPSTYA+I+STIQ+RGYV+ ++ Sbjct: 455 SLKISELEAQKHTTEPPPRYTEATLVKALEEKGIGRPSTYATILSTIQERGYVKKVKQKL 514 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 +G +V D LEE F ELM+Y FTA+ME LD+++ +EA+W V++ F+ +F LD+ Sbjct: 515 QPTYLGFVVNDLLEEKFPELMDYSFTAKMEEDLDKISLNEAKWNKVIEEFYKEFENDLDQ 574 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV 637 A K + + + TS C CG+ M IR + FL CSGY CK T +L Sbjct: 575 ASKISKVIKPKE---IKTSFKCEKCGKDMVIRWSKGVPFLACSGYP-----ECKNTRSL- 625 Query: 638 PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEG 697 + + ++CP+CG + + C N P C + Sbjct: 626 ---------NNNENGSTKKTLDKKCPQCGAQLVVRNGKRG-EFIACSNYPKCKFTQSITA 675 Query: 698 EFRIKGYDGPIVECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDP 755 + + C +CG ++ K + G+ + AC N +CK T Sbjct: 676 QVK----------CPQCGGDILKKQTKKGRTFWACANYPKCKFTLSNEP----------- 714 Query: 756 VPLPELPCEKSD-AYFVLRDGAAG-VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRY 813 C K +Y + + G FL + + ++ K Sbjct: 715 ---VPAECPKCKSSYMLKKKDRNGTEFLICHN---------------KACKGKIEIKEHS 756 Query: 814 LADAPQQDPEGNKTMVRFSRKTKQQ 838 P Q + N R ++Q Sbjct: 757 TGTDPAQQKDANPA-----RSGRKQ 776 >UniRef50_Q4L5V2 DNA topoisomerase 1 n=155 Tax=Firmicutes RepID=TOP1_STAHJ Length = 689 Score = 662 bits (1708), Expect = 0.0, Method: Composition-based stats. Identities = 283/758 (37%), Positives = 420/758 (55%), Gaps = 83/758 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG Y V +S+GH+RDLP Sbjct: 1 MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++MGVD N+E Y + GK VV +LK+ A+KA +++LA+D DREGEAIA Sbjct: 39 -------RSQMGVDVEDNYEPKYITIRGKGPVVKDLKKYAKKAKNVFLASDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ DD++ +RVVFNEITK+A++++F P + +D V+AQQARR +DR+VGY +S Sbjct: 92 WHLSKILELDDSKENRVVFNEITKDAVKESFKHPRGIEMDLVDAQQARRILDRLVGYNIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ +GLSAGRVQSVA+RLV++RE EI+ F PEE+W ++ + + H Sbjct: 152 PVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWSIEGEFRYKKSK-FTAKFLH 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 +KPF+ K+ + + L+ ++ + K T P PF TSTLQQ A+ +L F Sbjct: 211 YKNKPFKLKTKKDVEKVTAELDGDKFEITNVNKKEKTRNPANPFTTSTLQQEAARKLNFK 270 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 +KTMM+AQ+LYE G ITYMRTDST +SQ A + + YI D +GK YL Sbjct: 271 ARKTMMLAQQLYEGIDLKRQGTVGLITYMRTDSTRISQTAKDEAKQYIEDKYGKDYLSN- 329 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 K+ Q+AHEAIRP+ +K + D +LY+LIW +FVA QM PA D+ Sbjct: 330 -RTAKGKQGDQDAHEAIRPTSTLRTPYEMKAYLTRDQHRLYKLIWERFVASQMAPAILDT 388 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGDALTLVELTPA 467 L V + + +A G+ ++F G+ + + +++ LP ++KGD +T ++ PA Sbjct: 389 VALDVTQNNIKFRANGQTIKFKGFMTLYVEAKDDKDNEKENKLPNLSKGDEVTATQIEPA 448 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFT+PP R++EA LVK LE+ IGRPSTYA I TIQ R YV++E++RF ++GEIV Sbjct: 449 QHFTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVY 508 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 +++++ F E+++ +FT ME LD++A + W+ V+D+F+ F +++AE++ E+ + Sbjct: 509 EQVKDYFPEIIDVEFTVNMETLLDKIAEGDIGWRKVIDNFYGSFKLDVERAEEEMEKVEI 568 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 + DC CG M I+ G F+ CS + C+ T +V V Sbjct: 569 K---DEPAGEDCEVCGSPMVIKMGRYGKFMACSNFP-----DCRNTKAIVKTIGV----- 615 Query: 648 GEDAETNALRAKRRCPKCGTA-MDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDG 706 CPKC + R + C N P CD ++ Sbjct: 616 -------------TCPKCKDGDVVERKSKKNRLFYGCSNYPECDFISWDK---------P 653 Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILR 744 +C KC + + C+N C ++ + Sbjct: 654 VGRDCPKCNHYLMEHKKGRSSQVICSN--CDYKEEVQK 689 Score = 60.5 bits (145), Expect = 2e-07, Method: Composition-based stats. Identities = 28/133 (21%), Positives = 44/133 (33%), Gaps = 23/133 (17%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 + R E E CE + V++ G G F+A + FP R T+A + Sbjct: 552 FKLDVERAEEEMEKVEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACSNFPDCRNTKAIVK 611 Query: 798 E--------------ELYRFRDRL-------PEKLRYLADAP--QQDPEGNKTMVRFSRK 834 E ++RL PE D P + P+ N ++ + Sbjct: 612 TIGVTCPKCKDGDVVERKSKKNRLFYGCSNYPECDFISWDKPVGRDCPKCNHYLMEHKKG 671 Query: 835 TKQQYVSSEKDGK 847 Q + S D K Sbjct: 672 RSSQVICSNCDYK 684 >UniRef50_A6DDI1 DNA topoisomerase n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DDI1_9PROT Length = 725 Score = 662 bits (1707), Expect = 0.0, Method: Composition-based stats. Identities = 281/805 (34%), Positives = 414/805 (51%), Gaps = 90/805 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP+KA+TI +LG +Y V +S GHIRDLP + K Sbjct: 1 MAKKLIIVESPSKARTIKNFLGKEYEVIASKGHIRDLPKTSFGIKI-------------- 46 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + Y V + V ELK+ A+KA+ IY+ATD DREGEAI Sbjct: 47 --------------EEDKFIPQYRVTKDHQSVAKELKEKAKKAETIYIATDEDREGEAIG 92 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +H+ VIG D + R+VF+EITK AI+ A P +L+IDRVNAQQARR +DR+VGY +S Sbjct: 93 FHIAHVIGKDPSSLPRIVFHEITKTAIKNALKNPRKLDIDRVNAQQARRLLDRIVGYKLS 152 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLL KKI +GLSAGRVQS A++LVV+REREIK F+P+E+W ++ G ++ Sbjct: 153 PLLNKKIQKGLSAGRVQSAALKLVVDREREIKEFIPKEYWSIEGIFKEVEG--NLIKYNG 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + F +++ + V+ L+ Y V + E K TT+K APF+TSTLQQ AS+ LGF Sbjct: 211 KKLEKFDLKTRDEAEKIVNELKPLEYEVSKIEKKTTTTKSPAPFMTSTLQQVASSELGFS 270 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 +KTM +AQ+LYE G ITYMRTDS N++++A +I +N G +Y Sbjct: 271 PRKTMQIAQKLYEGVKTPVGETGIITYMRTDSLNIAKEAQEAAINFIKENIGSEYAEAKT 330 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 + +QEAHEAIRP DV + + LK+ + D KLY LI+ +F+A QM AK+++ Sbjct: 331 YT-TKNQTAQEAHEAIRPVDVRLTPDDLKNYLSKDELKLYSLIYNRFLASQMKDAKFETQ 389 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + + K G+ L FDG+ KV K D +LP +G+ L E+ QHFT Sbjct: 390 NIYLTNEKGEFKISGKKLIFDGFYKVYG---KRGADTLLPEFKEGEKLKPEEIKATQHFT 446 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPP R++EASL+K+LE GIGRPSTYA I+ +Q+R YV +++++ + ++ V + LE Sbjct: 447 KPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYVEIKDKKLHPTEIAFNVIETLE 506 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 ++F ++++ FTA ME LD++A +W+ +L F++ F + ++K ++ Sbjct: 507 KHFPDIVDAKFTANMEEMLDEIARGNKDWQEMLKEFYNPFMKLIEKGYEEI----PSQKI 562 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 T CP CG + IR G F+ CS + +CK T + + E Sbjct: 563 AKPTGELCPECGNPLVIRKGRFGEFIACSNFP-----KCKYTRPIEEKEEK--------- 608 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVEC 711 + +C KCG M + C N P C + V+C Sbjct: 609 -----KVDVKCDKCGADMVIKRGKRG-EFLACSNYPECKNTKPLNP-----PEVLEDVKC 657 Query: 712 EKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYF 770 +CG ++ + R G++ C N +C K C++ Sbjct: 658 PECGGDIIKRKSRRGEFYGCGNYPKCNFISKYRP--------------VNEKCDECGYMM 703 Query: 771 VLRDGAAGVFLAANTFPKSRETRAP 795 R L K + + Sbjct: 704 AKRTYRNKEVLEC---IKCKARKEI 725 Score = 95.2 bits (235), Expect = 1e-17, Method: Composition-based stats. Identities = 32/128 (25%), Positives = 56/128 (43%), Gaps = 11/128 (8%) Query: 695 EEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKE 753 E K C +CG+ + ++ GRFG+++AC+N +CK TR I E Sbjct: 554 YEEIPSQKIAKPTGELCPECGNPLVIRKGRFGEFIACSNFPKCKYTRPIEEKEEKK---- 609 Query: 754 DPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRY 813 ++ C+K A V++ G G FLA + +P+ + T+ E+ + PE Sbjct: 610 -----VDVKCDKCGADMVIKRGKRGEFLACSNYPECKNTKPLNPPEVLE-DVKCPECGGD 663 Query: 814 LADAPQQD 821 + + Sbjct: 664 IIKRKSRR 671 Score = 70.9 bits (172), Expect = 2e-10, Method: Composition-based stats. Identities = 29/254 (11%), Positives = 60/254 (23%), Gaps = 8/254 (3%) Query: 560 WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC 619 + L D + E+G + + L G Sbjct: 373 YNRFLASQMKDAKFETQNIYLTNEKGEFKISGKKLIF-------DGFYKVYGKRGADTLL 425 Query: 620 SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR- 678 + K + + + P + L + Sbjct: 426 PEFKEGEKLKPEEIKATQHFTKPPERYTEASLIKKLESLGIGRPSTYAPTITLLQNRNYV 485 Query: 679 KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKN 738 ++ +PT + + E + + + E Sbjct: 486 EIKDKKLHPTEIAFNVIETLEKHFPDIVDAKFTANMEEMLDEIARGNKDWQEMLKEFYNP 545 Query: 739 TRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVE 798 K++ G P + C + V+R G G F+A + FPK + TR + Sbjct: 546 FMKLIEKGYEEIPSQKIAKPTGELCPECGNPLVIRKGRFGEFIACSNFPKCKYTRPIEEK 605 Query: 799 ELYRFRDRLPEKLR 812 E + + + Sbjct: 606 EEKKVDVKCDKCGA 619 >UniRef50_Q2FZ32 DNA topoisomerase 1 n=260 Tax=Bacteria RepID=TOP1_STAA8 Length = 689 Score = 660 bits (1702), Expect = 0.0, Method: Composition-based stats. Identities = 285/758 (37%), Positives = 419/758 (55%), Gaps = 83/758 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESPAKAKTI KYLG Y V +S+GH+RDLP Sbjct: 1 MADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++MGVD N+E Y + GK VV ELK+ A+KA +++LA+D DREGEAIA Sbjct: 39 -------RSQMGVDTEDNYEPKYITIRGKGPVVKELKKHAKKAKNVFLASDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ +D++ +RVVFNEITK+A++++F P E+ ++ V+AQQARR +DR+VGY +S Sbjct: 92 WHLSKILELEDSKENRVVFNEITKDAVKESFKNPREIEMNLVDAQQARRILDRLVGYNIS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ +GLSAGRVQSVA+RLV++RE EI+ F PEE+W ++ + + H Sbjct: 152 PVLWKKVKKGLSAGRVQSVALRLVIDRENEIRNFKPEEYWTIEGEFRYKKSK-FNAKFLH 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 +KPF+ K+ + + L+ ++ + K T P PF TSTLQQ A+ +L F Sbjct: 211 YKNKPFKLKTKKDVEKITAALDGDQFEITNVTKKEKTRNPANPFTTSTLQQEAARKLNFK 270 Query: 301 VKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 +KTMM+AQ+LYE G ITYMRTDST +S A + YI+D +G+ Y S Sbjct: 271 ARKTMMVAQQLYEGIDLKKQGTIGLITYMRTDSTRISDTAKVEAKQYITDKYGESY--TS 328 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDS 410 + + K+ Q+AHEAIRPS + +K + D +LY+LIW +FVA QM PA D+ Sbjct: 329 KRKASGKQGDQDAHEAIRPSSTMRTPDDMKSFLTKDQYRLYKLIWERFVASQMAPAILDT 388 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGDALTLVELTPA 467 +L + GD + +A G+ ++F G+ + +++ LP + +GD +T ++ PA Sbjct: 389 VSLDITQGDIKFRANGQTIKFKGFMTLYVETKDDSDSEKENKLPKLEQGDKVTATQIEPA 448 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QH+T+PP R++EA LVK LE+ IGRPSTYA I TIQ R YV++E++RF ++GEIV Sbjct: 449 QHYTQPPPRYTEARLVKTLEELKIGRPSTYAPTIDTIQKRNYVKLESKRFVPTELGEIVH 508 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 ++++E F E+++ +FT ME LD++A + W+ V+D FFS F Q +++A EE Sbjct: 509 EQVKEYFPEIIDVEFTVNMETLLDKIAEGDITWRKVIDGFFSSFKQDVERA---EEEMEK 565 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 + DC CG M I+ G F+ CS + C+ T +V V Sbjct: 566 IEIKDEPAGEDCEICGSPMVIKMGRYGKFMACSNFP-----DCRNTKAIVKSIGV----- 615 Query: 648 GEDAETNALRAKRRCPKCGTA-MDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDG 706 +CPKC + R + C P CD ++ R Sbjct: 616 -------------KCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGR------ 656 Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILR 744 +C KC + + C+N C + Sbjct: 657 ---DCPKCNQYLVENKKGKTTQVICSN--CDYKEAAQK 689 Score = 59.3 bits (142), Expect = 7e-07, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 41/109 (37%), Gaps = 6/109 (5%) Query: 736 CKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAP 795 + + R E E CE + V++ G G F+A + FP R T+A Sbjct: 550 SSFKQDVERAEEEMEKIEIKDEPAGEDCEICGSPMVIKMGRYGKFMACSNFPDCRNTKAI 609 Query: 796 LVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEK 844 + + P+ D ++ + N+ S+ + ++S +K Sbjct: 610 ----VKSIGVKCPKCND--GDVVERKSKKNRVFYGCSKYPECDFISWDK 652 Score = 58.6 bits (140), Expect = 1e-06, Method: Composition-based stats. Identities = 22/142 (15%), Positives = 36/142 (25%), Gaps = 29/142 (20%) Query: 656 LRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCG 715 A C CG+ M + K C N P C + + +C KC Sbjct: 571 EPAGEDCEICGSPMVIK-MGRYGKFMACSNFPDCRNTKAIVKSIGV--------KCPKCN 621 Query: 716 -SEMHLKMGRFG-KYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL 772 ++ + + + C+ EC G C K + Y V Sbjct: 622 DGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRD--------------CPKCNQYLVE 667 Query: 773 RDGAAGVFLAANTFPKSRETRA 794 + + A Sbjct: 668 NKKGKTTQVICSN---CDYKEA 686 >UniRef50_C9LM02 DNA topoisomerase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LM02_9FIRM Length = 799 Score = 659 bits (1701), Expect = 0.0, Method: Composition-based stats. Identities = 280/777 (36%), Positives = 400/777 (51%), Gaps = 75/777 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L+IVESPAKAKTI + LGSDY V +S+GH+RDLP Sbjct: 31 GKHLIIVESPAKAKTIERILGSDYKVLASMGHLRDLP----------------------- 67 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +GVD ++++ Y + V+ L++ A K+ I LATD DREGEAI+W Sbjct: 68 ------QRTLGVDVANDFKPEYVSSAERADVIENLQKEANKSKDILLATDPDREGEAISW 121 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL +++ D +R+ F+EIT AI++A P ++++RV+AQQARR +DR+VGY +SP Sbjct: 122 HLSKLLDVDPRSNARIAFHEITPPAIKEAVLHPEPIDLNRVDAQQARRVLDRLVGYKLSP 181 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LWK+I RGLSAGRVQSVA RL+ ERE EI+AF P E+W V+ T E+ ++T Sbjct: 182 WLWKQIYRGLSAGRVQSVATRLICEREEEIRAFKPVEYWTVEGIYRTEEKESFKAKLTQV 241 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + K + N E+ V + K + K P+ TST+QQ A RL FG Sbjct: 242 DGKEAKINNAEEADRVVRGILKQPAEITSVTKTKKQRKAKPPYTTSTMQQDAVNRLNFGS 301 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KKTM +AQ LYE G ITYMRTDST +S + + VR YI +GK YLP P Sbjct: 302 KKTMALAQMLYEGIEIPGHGHVGLITYMRTDSTRISDEMIKQVRPYIERVYGKDYLPPKP 361 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 N YA ++SQ+AHEAIRP+++ + L + D +LY LIW +F+A QM P +T Sbjct: 362 NVYARGKDSQDAHEAIRPTNLQFAPDMLAAVLSRDQLRLYTLIWNRFLASQMAPQISQAT 421 Query: 412 TLTVGAGDFRLKARGRILRFDGW---TKVMPALRKGDEDRILPAVNKGDALTLVELTPAQ 468 + +G + L+A G + FDG+ V + +E ILPA++KG + + Q Sbjct: 422 NAVLQSGIYTLRATGTQILFDGFTVLRTVKEKKQDNEELPILPALHKGHTVLNTKAEGEQ 481 Query: 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528 HFT PP R++EASL+K LE++GIGRPSTYA I+ TIQ R YV E ++F +G VTD Sbjct: 482 HFTAPPPRYTEASLIKTLEEKGIGRPSTYAPILDTIQRRKYVEKEGKQFVPTDIGFKVTD 541 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 L++ F +++ DFTAQ+E LD++A+ +A +K V+ F+ F ++L A E + Sbjct: 542 LLKKYFAGIVSVDFTAQLETWLDKIADGKATYKKVMSGFWDVFEKELQNAN--LEAAKAK 599 Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPP--------------------KE 628 ++ + C CG M ++ + G +L C + K Sbjct: 600 EENQEVSDVICEKCGAHMIVKMSRYGKYLACPNFPSCKNIKPYHTGEEKEEISDVDCDKC 659 Query: 629 RCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGT-AMDSYLIDPKRKLHVCGNNP 687 K P L E + + CPKC + R + C P Sbjct: 660 GAKMVYRQGPYGRYLKCPECGQNKAIVIDTGIECPKCHEGHLVKRRSKRGRYFYGCSRYP 719 Query: 688 TCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG-KYMACTNEECKNTRKIL 743 CD +E C CG+ K+ + + + C+N EC K Sbjct: 720 ACDMAVWDEPVNEF---------CSVCGAIKVKKVRKNKEEELICSNPECTTHPKKK 767 Score = 68.6 bits (166), Expect = 9e-10, Method: Composition-based stats. Identities = 34/145 (23%), Positives = 58/145 (40%), Gaps = 27/145 (18%) Query: 700 RIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPL 758 + + + V CEKCG+ M +KM R+GKY+AC N CK N + E+ + Sbjct: 599 KEENQEVSDVICEKCGAHMIVKMSRYGKYLACPNFPSCK-------NIKPYHTGEEKEEI 651 Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAP 818 ++ C+K A V R G G +L P+ + +A +++ Sbjct: 652 SDVDCDKCGAKMVYRQGPYGRYLKC---PECGQNKAIVID----------------TGIE 692 Query: 819 QQDPEGNKTMVRFSRKTKQQYVSSE 843 + R S++ + Y S Sbjct: 693 CPKCHEGHLVKRRSKRGRYFYGCSR 717 Score = 55.5 bits (132), Expect = 8e-06, Method: Composition-based stats. Identities = 19/95 (20%), Positives = 33/95 (34%), Gaps = 11/95 (11%) Query: 742 ILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELY 801 N E A KE+ + ++ CEK A+ +++ G +LA FP + + E Sbjct: 589 QNANLEAAKAKEENQEVSDVICEKCGAHMIVKMSRYGKYLACPNFPSCKNIKPYHTGEEK 648 Query: 802 RFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 + D G K + R + Sbjct: 649 EEISDVD-----------CDKCGAKMVYRQGPYGR 672 >UniRef50_C6WSV7 DNA topoisomerase n=4 Tax=Proteobacteria RepID=C6WSV7_METML Length = 864 Score = 657 bits (1694), Expect = 0.0, Method: Composition-based stats. Identities = 294/856 (34%), Positives = 436/856 (50%), Gaps = 89/856 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP+KAKT+ KYLGSD+ V +S GH+RDL Sbjct: 1 MSK-LLIVESPSKAKTLKKYLGSDFEVLASYGHVRDL----------------------- 36 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VD + + Y+++ K V + + + AD IYLATD DREGEAI+ Sbjct: 37 ------IPKNGAVDTENQFAMKYDIIERNSKHVDAIAKAVKNADSIYLATDPDREGEAIS 90 Query: 121 WHLREVIGGDDARYS----RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WH+ E++ + RVVF+EITK A+ A +P ++++ VNAQQARR +D +VG Sbjct: 91 WHIAEILKSKKLLKNKLMKRVVFHEITKGAVEHAIAEPRDISMPMVNAQQARRALDYLVG 150 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP--SGEAL 234 + +SPLLWKKI RGLSAGRVQS A+RL+VERE EI+AF +E+W + +A Sbjct: 151 FNLSPLLWKKIRRGLSAGRVQSPALRLIVERELEIEAFKSQEYWSIHLDALKHQHGFKAK 210 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLL---EKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 +Q+ +Q + F +N +Q V L + +V E K + P APF TSTLQQ Sbjct: 211 LVQLNNQKVEQFTVINHDQQSDIVGKLLLASAGKTTVSRVEKKQRSRSPAAPFTTSTLQQ 270 Query: 292 AASTRLGFGVKKTMMMAQRLYEAG--------YITYMRTDSTNLSQDAVNMVRGYISDNF 343 A +LGF + M +AQ+LYE ITYMRTDS +L+ +AV +R Y+ NF Sbjct: 271 EAVRKLGFTTSRAMRVAQQLYEGVDVGGGTVGLITYMRTDSFSLATEAVMQIRDYVKKNF 330 Query: 344 GKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVAC 401 +YLP+SP Y +K +++QEAHEAIRP+D++ S++ + + KLY++IW++ +AC Sbjct: 331 DTEYLPKSPVMYKTKSKSAQEAHEAIRPTDISRTPTSVRQYLNDEQFKLYEMIWKRALAC 390 Query: 402 QMTPAKYDSTTLTVGAGD--FRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKG 456 QM PAK+D+ ++ + G +A G+ L F G+ V + + + LP + G Sbjct: 391 QMAPAKFDAVSVDLSVGSDANLFRATGQTLVFPGFIAVYMEGSDDEEEEAESKLPNLETG 450 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 + LT+ ++ QHFT+PP R+SEASLVK LE+ GIGRPSTYASIIST+QDR YV ++ +R Sbjct: 451 EILTVEKIYGEQHFTEPPPRYSEASLVKVLEEYGIGRPSTYASIISTLQDREYVLLDKKR 510 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 F +G +V L E+F + ++YDFTA +EN+LD VA E +W ++D F+ DF QQ+ Sbjct: 511 FTPTDVGRVVNKFLTEHFTKYVDYDFTANLENALDSVAEGERDWVPLMDEFWQDFNQQIH 570 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 + + L CP CG+ + + + G F+GC+GY PK K +I+ Sbjct: 571 N------KADVERPGNELIDEACPKCGKPLQKQLSRFGSFIGCTGYNDTPKCDYKRSIDG 624 Query: 637 VPENEVLNVLEGEDAETNALRAKRRCPK-----CGTAMDSYLIDPKRKLHVCGNNPTCDG 691 V G DA T+ P G A++ PKR Sbjct: 625 TANAGTDPVSIGVDAATSKEIYLMNGPYGPYLQVGMAVEGEKKKPKRVSIPKEIA---LA 681 Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPP 751 E + + + ++ +GRFG Y+ N + K + Sbjct: 682 DVNLETANMLLSLPRDLGLHPETNKKIIANIGRFGPYI---NHDAKFKSIPKNLSVFSID 738 Query: 752 KE------------DPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEE 799 + D + G G ++ + + RA L + Sbjct: 739 LDGAVALLAQAHTGPAPLCSLGSHPTEDGQIEVFAGRYGPYV------QHGKLRATLPKS 792 Query: 800 LYRFRDRLPEKLRYLA 815 + + E L L+ Sbjct: 793 IEPESLTMEEALELLS 808 >UniRef50_Q01N68 DNA topoisomerase n=7 Tax=Bacteria RepID=Q01N68_SOLUE Length = 934 Score = 655 bits (1689), Expect = 0.0, Method: Composition-based stats. Identities = 315/888 (35%), Positives = 456/888 (51%), Gaps = 96/888 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M KALVIVESPAKAKTINKYLG YVVK+S+GHI+DLP Sbjct: 1 MPKALVIVESPAKAKTINKYLGKQYVVKASLGHIKDLPKRD------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VD H +E YE++ GK+K++ EL+ A+ D IYLA D DREGEAI Sbjct: 42 ----------LAVDVEHGFEPRYEIIEGKKKLMGELRSAAKGVDQIYLAADPDREGEAIC 91 Query: 121 WHLREVIGGDD--ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 +HL+E + + RV+FNEITK A+ +AF KP ++N + V+AQQARR +DR+VGY Sbjct: 92 FHLQEELRSKKDGPAFFRVMFNEITKKAVEKAFEKPLQVNTNLVDAQQARRVLDRLVGYK 151 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +SPLLW K+ RGLSAGRVQ+VA+R++VEREREI+AF +E+W VD + L+ ++ Sbjct: 152 ISPLLWDKVRRGLSAGRVQTVALRVIVEREREIRAFQKKEYWTVDVDLLARTAPVLSTRL 211 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 ND+ N++ T + V+ L Y V + P APFITSTLQQ +S +L Sbjct: 212 IKANDETPELPNQQTTDSLVAQLSGVDYIVKSVATREKRRNPVAPFITSTLQQDSSRKLR 271 Query: 299 FGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 F VK+TMM+AQRLYE G ITYMRTDST S DA++ VR YI + +G +LP Sbjct: 272 FSVKRTMMLAQRLYEGIEIGRDGAVGLITYMRTDSTRTSDDAISDVRHYIGERYGAPFLP 331 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKY 408 +PN Y SK+ +Q+AHEAIRP+ + E ++ + D KLY+LIW +FVA QM PA + Sbjct: 332 PAPNVYKSKKEAQDAHEAIRPTSMAYSPEVVEQYLPEDEMKLYRLIWNRFVASQMMPALF 391 Query: 409 DSTTLTVGAG-----DFRLKARGRILRFDGWTKVMPALRKGDEDRI------LPAVNKGD 457 D TT+ V A ++ +A G + +FDG+ KV + ++ LP V +G+ Sbjct: 392 DQTTIDVSAKAANGVEYTFRATGSVPKFDGFLKVYQEGKDQTDEDDEELKHRLPLVTEGE 451 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L L + P QHFT+PP R++EA+LVK LE G+GRPSTYA+I+STIQ+R YV E RF Sbjct: 452 VLRLEAIRPEQHFTEPPPRYNEATLVKRLEADGVGRPSTYATILSTIQEREYVNKEAGRF 511 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 ++G +VTD L E+F ++ + +TA+ME LD++ + +W+A + F+ F + L Sbjct: 512 TPTELGMVVTDLLLESFDDIFDVKYTARMEEELDEIEEGKLDWRAAMSEFYGRFDKDLKH 571 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYAL------------- 624 AE+ + T + C CGR + I+ G F+ C+GY Sbjct: 572 AEEHMTDIKR---MEKPTDLICEKCGRPLVIKWGKHGSFIACTGYPDFSSKSIESDLEKV 628 Query: 625 -------PPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLID-- 675 + K ++L + PK MD+ L Sbjct: 629 QKDIEVRRQRALKKIELSLEKLRAKYPDRTITWGQDGEFLVIPSAPKIPKPMDAALKKLE 688 Query: 676 PKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEE 735 + + + + + + ++ + L + R ++ Sbjct: 689 KEIAVKRSEDRGKIEARLEKLQARYPQMKGFYDLDLRDTAEGVALTVRRKEEF------- 741 Query: 736 CKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAP 795 C TR++ + + E CE VL+ G G F A + +P + TR Sbjct: 742 CTYTRELTVDLPDLEGADLSEQGEEESCENCGRPMVLKKGRFGTFFACSEYPDCKTTRQI 801 Query: 796 LVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 + L EK PQ D N ++++ R + S Sbjct: 802 G--GTQKKDVPLDEK------CPQCD---NNLVMKYGRFG-EFTACSN 837 Score = 93.2 bits (230), Expect = 4e-17, Method: Composition-based stats. Identities = 34/228 (14%), Positives = 61/228 (26%), Gaps = 47/228 (20%) Query: 568 FSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPK 627 +F + D + C CGR M ++ G F CS Y Sbjct: 738 KEEFCTYTRELTVDLPDLEGADLSEQGEEESCENCGRPMVLKKGRFGTFFACSEYP---- 793 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNP 687 CKTT + + + +CP+C + + C N P Sbjct: 794 -DCKTTRQIG------------GTQKKDVPLDEKCPQCDNNLVMKY-GRFGEFTACSNYP 839 Query: 688 TCDGYEIEEGEFRIKGYDGPIVECEKCG-SEMHLKMGRFGK-YMACTN-EECKNTRKILR 744 TC V+C +C ++ + + GK + C +C Sbjct: 840 TCKY----------VKQKTIGVKCPECSEGDIIERRSKKGKTFYGCNRYPDCTFVAWGKP 889 Query: 745 NGEVAPPKEDPVPLPELPCEKSDAY-FVLRDGAAGVFLAANTFPKSRE 791 C + + + + +G F + + Sbjct: 890 --------------VAEKCPECGSPYMIEKFLKSGAFWQCPNA-ECKH 922 >UniRef50_B3EPW7 DNA topoisomerase n=12 Tax=Chlorobiaceae RepID=B3EPW7_CHLPB Length = 804 Score = 654 bits (1688), Expect = 0.0, Method: Composition-based stats. Identities = 289/776 (37%), Positives = 411/776 (52%), Gaps = 86/776 (11%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK L++VESP+KAKTINKYLGSDY+V +SVGHI+DLP Sbjct: 12 GKTLIVVESPSKAKTINKYLGSDYLVFASVGHIKDLPKKE-------------------- 51 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +G+D +N+E YEV+ GKEKVV +LK+LA +A+ I +ATD DREGEAIAW Sbjct: 52 ---------IGLDFDNNYEPRYEVISGKEKVVRQLKKLAGQANDILIATDPDREGEAIAW 102 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ + RV+FNEITK AI +A N P +++ V +QQ R+ +D++VGY +SP Sbjct: 103 HIANEVDAAQKPVHRVLFNEITKKAILEAINDPLQIDYRLVRSQQTRQGLDKIVGYKISP 162 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LW + RGLSAGRVQSV++RL+ ERE EI F P+E+W + A TT SGE + ++ Sbjct: 163 FLWNVVMRGLSAGRVQSVSLRLICEREAEIDKFEPKEYWTIFADFTTGSGETFSTKLVRI 222 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + N+ + S + Y V E + KP PF TS LQQAAS +LGFG Sbjct: 223 DSNKAEITNQSDAEKTASDILSRIYGVAEITPRVQQRKPPFPFTTSLLQQAASNQLGFGS 282 Query: 302 KKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KKTM +AQ+LYE G ITYMRTDST +S +AV +I+ +FG ++ Sbjct: 283 KKTMRVAQQLYEGIDLGPEGATGLITYMRTDSTRVSGEAVEQAERFITQHFGPEF-TGGG 341 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 + +Q+AHEAIRP+ V E++K + +D KLY+LIW++F+A +M PAK + T Sbjct: 342 QAAKKGKKTQDAHEAIRPTGVPRTPETMKPFLSSDQYKLYELIWKRFLASRMAPAKIEQT 401 Query: 412 TLTVGAGD--FRLKARGRILRFDGWTKVMPALRK----------GDEDRI----LP-AVN 454 + V + F +A G + F G+ KV ++ DE++ LP + Sbjct: 402 RVDVADHEKQFIFRASGSNVLFPGFLKVYNEQKELDYEARKSTREDEEKEQIVKLPRNLT 461 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN 514 + LTL L Q FT+PPARF+EASLVKEL+ GIGRPSTYA I ST+QDR YV +E Sbjct: 462 VNEKLTLDTLDKKQSFTRPPARFTEASLVKELDNYGIGRPSTYAGIFSTLQDRRYVELEK 521 Query: 515 RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQ 574 ++ ++G+ V+ L NF +L N FTA MEN LD++A + E++ VLD F+ Sbjct: 522 KKIIPTELGKDVSMILVANFPDLFNVTFTAHMENELDKIAAGDDEYEQVLDSFYKPLESA 581 Query: 575 LDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK-MGIRTASTGVFLGCSGYALPPKERCKTT 633 L + C CG+ M I+ ++G FLGCS Y CK Sbjct: 582 LS------VRKNDPLLPQNTDAETCDKCGKGKMIIKWTASGKFLGCSSYPA-----CKNI 630 Query: 634 INLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE 693 L + +C C C P C+ Sbjct: 631 KPLA------------SSRVRPKETGIKCHGCENGRMVLRNGRFGPFLACTGYPDCNTLL 678 Query: 694 IEEGEFRIKGYDGPIVE----CEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILR 744 + + +I+ P +E C KCG+ ++L+ G+ G ++ C+ +C+ + + Sbjct: 679 KLDKQRKIEPPKTPPLETDLACPKCGAPLYLRTGKRGLWLGCSKFPKCRGRQAWGQ 734 Score = 110 bits (275), Expect = 3e-22, Method: Composition-based stats. Identities = 41/162 (25%), Positives = 61/162 (37%), Gaps = 5/162 (3%) Query: 635 NLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEI 694 + E + D C KCG K C + P C + Sbjct: 573 SFYKPLESALSVRKNDPLLPQNTDAETCDKCGKGKMIIKWTASGKFLGCSSYPACKNIKP 632 Query: 695 EEGEFRIKGYDGPIVECEKC-GSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPK 752 ++C C M L+ GRFG ++ACT +C K+ + ++ PPK Sbjct: 633 --LASSRVRPKETGIKCHGCENGRMVLRNGRFGPFLACTGYPDCNTLLKLDKQRKIEPPK 690 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 P+ +L C K A LR G G++L + FPK R +A Sbjct: 691 TPPLET-DLACPKCGAPLYLRTGKRGLWLGCSKFPKCRGRQA 731 Score = 74.4 bits (181), Expect = 2e-11, Method: Composition-based stats. Identities = 33/161 (20%), Positives = 55/161 (34%), Gaps = 17/161 (10%) Query: 697 GEFRIKGYDGPIVECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKED 754 + + C+KCG +M +K GK++ C++ CK N + Sbjct: 586 KNDPLLPQNTDAETCDKCGKGKMIIKWTASGKFLGCSSYPACK-------NIKPLASSRV 638 Query: 755 PVPLPELPCEKS-DAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRY 813 + C + VLR+G G FLA +P +L + R P K Sbjct: 639 RPKETGIKCHGCENGRMVLRNGRFGPFLACTGYPDCNTLL-----KLDKQRKIEPPKTPP 693 Query: 814 LADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAF 854 L G +R ++ ++ K K G A+ Sbjct: 694 LETDLACPKCGAPLYLRTGKRG--LWLGCSKFPKCRGRQAW 732 >UniRef50_C6P2V7 DNA topoisomerase n=2 Tax=Proteobacteria RepID=C6P2V7_9PROT Length = 876 Score = 653 bits (1685), Expect = 0.0, Method: Composition-based stats. Identities = 293/869 (33%), Positives = 428/869 (49%), Gaps = 95/869 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M L+IVESPAKAKT+ KYLG D+ V +S GH+RDL Sbjct: 1 MATNLLIVESPAKAKTLKKYLGKDFEVLASYGHVRDL----------------------- 37 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VDP N+ YE + K V + + A +ADHI+LA D DREGEAIA Sbjct: 38 ------IPKTGAVDPDDNFAMKYETIARNAKHVDAIAKAAAEADHIFLAPDPDREGEAIA 91 Query: 121 WHLREVIGGDD----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WH+ E++ G RVVF EIT++A+R+A P E++I VNAQQARR +D +VG Sbjct: 92 WHISELLKGKRALKGKTMQRVVFYEITQSAVREAVAHPREISIPLVNAQQARRALDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS--GEAL 234 + +SPLLW+KI GLSAGRVQS A+RL+VERE EI+ F +E+W V + S +A Sbjct: 152 FNLSPLLWRKIRPGLSAGRVQSPALRLIVERELEIEKFKSQEYWSVHLDSQKNSIPFKAK 211 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY--SVLEREDKPTTSKPGAPFITSTLQQA 292 Q + + ++ + A + L A+ V+ E K P APF TSTLQQ Sbjct: 212 LYQFQGKRMEQLTIGSQAEYDAIHAKLVDAKLPPKVVRVEKKGKQRSPAAPFTTSTLQQE 271 Query: 293 ASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFG 344 A +LG +TM AQ LYE G ITYMRTDS NL+ +AV +R YI DNF Sbjct: 272 AVRKLGMTSDRTMRTAQSLYEGVDIGGQTIGLITYMRTDSVNLANEAVAEMREYIKDNFA 331 Query: 345 KKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQ 402 YLP Y SK +N+QEAHEAIRP+ + +SL+D + D +LY++IW++ +A Q Sbjct: 332 GDYLPVKQPVYKSKSKNAQEAHEAIRPTSILRTPDSLRDHLNIDQMRLYEMIWKRTLASQ 391 Query: 403 MTPAKYDSTTLTVG--AGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGD 457 M+PA++D+ ++ + + D +A G+ L F G+ V + ++ LP + +GD Sbjct: 392 MSPARFDTVSVDIRLSSDDTLFRASGQTLVFPGFIGVYMEDVDDAEEEDSAKLPPLVEGD 451 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L + +L QHFT+PP RFSEASLVK LE+ GIGRPSTYA+IIST+Q R Y ++ +RF Sbjct: 452 VLPVDKLYGEQHFTQPPPRFSEASLVKALEEYGIGRPSTYATIISTLQAREYATLDKKRF 511 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 +G +V L E+F ++Y FTA +E+ LD ++ + +W VL+ F+ F + + Sbjct: 512 MPTDVGRVVIKFLNEHFTRYVDYGFTANLEDELDDISEGKRDWIPVLNEFWKGFNKLIS- 570 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV 637 E+ + + CP CG+ + R G F+GC+GY C T +L Sbjct: 571 -----EKKDVDRPGTEILEETCPKCGKPLSKRLGKRGSFIGCTGYP-----ECDYTRSLG 620 Query: 638 PENEVLNVLE--GEDAETNALRAKRRCPKC-----GTAMDSYLIDPKRKLHVCGNNPTCD 690 E + + G+ +TN L R P G ++ PKR Sbjct: 621 GEEDAGESRKELGQHPDTNQLVLLLRGPYGPYVQLGEMIEGEKTKPKRVSWPKEL---PL 677 Query: 691 GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAP 750 ++ + + G ++ + +GRFG Y+ + K + Sbjct: 678 EQADLPSALKLLSLPREVGAHPETGKKVIVNIGRFGPYIG---HDGKFKSIPRTDSIFDI 734 Query: 751 PKEDPVPL-------------PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 + V L A + G G ++ + + A L Sbjct: 735 GLDRSVELLAQARSGGATVLRTLGEHPDDKAPIEVCSGRYGPYV------RHGKINATLP 788 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNK 826 +++ L E L +A + G Sbjct: 789 KDVTPEAVTLEEALEMIAAKAAKGGTGKA 817 >UniRef50_B6RA74 DNA topoisomerase n=6 Tax=Alphaproteobacteria RepID=B6RA74_9RHOB Length = 931 Score = 652 bits (1682), Expect = 0.0, Method: Composition-based stats. Identities = 272/876 (31%), Positives = 423/876 (48%), Gaps = 100/876 (11%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 +VIVESPAKAKTINKYLG DY V +S GH+RDLP Sbjct: 2 NVVIVESPAKAKTINKYLGKDYTVLASYGHVRDLPPKDG--------------------- 40 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 V P ++ + V +K +SE+ ++AD + LATD DREGEAI+WH+ Sbjct: 41 --------SVLPDDDFAMSWSVDSKSQKRLSEIASAVKEADRLILATDPDREGEAISWHV 92 Query: 124 REVI----GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 EV+ D + RVVFN ITK++I +A P EL+ V+A ARR +D +VG+ + Sbjct: 93 LEVLKKKRVLKDKKIERVVFNAITKSSILEAMKNPRELDEPLVDAYLARRALDYLVGFTL 152 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP+LW+K+ SAGRVQSVA+RLV +RE EI+ F +E+W + A+ TP + ++T Sbjct: 153 SPVLWRKLPGARSAGRVQSVALRLVCQRENEIETFQSQEYWSILANLNTPENAPVQARLT 212 Query: 240 HQNDKP---FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 + + N+++ +L+ A + V E KP P APF TSTLQQ AS + Sbjct: 213 GFDGQKITRLDIKNEQEATTIKQMLDGASFQVSNVESKPQRRNPYAPFTTSTLQQEASRK 272 Query: 297 LGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LGF +TM +AQ+LYE G ITYMRTD ++Q+A+ RG I+ +G +Y+ Sbjct: 273 LGFAAARTMQVAQKLYEGANIGGETTGLITYMRTDGVQIAQEAITSARGVIASRYGDEYV 332 Query: 349 PESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPA 406 PE P Y+SK +N+QEAHEAIRP+D+ + ++ D +LY+LIW++ +A QM A Sbjct: 333 PEKPRMYSSKAKNAQEAHEAIRPTDLTRHPRDMAKFLDEDGARLYELIWKRTIASQMESA 392 Query: 407 KYDSTTLTVG----AGDFRLKARGRILRFDGWTKVMPALR---KGDEDRILPAVNKGDAL 459 + TT+ + A L+A G ++RFDG+ + + + +E + LP + +GD+L Sbjct: 393 VLERTTVDIDAVNGAKKAALRASGSVVRFDGFLTLYQEGKDDEEDEESKRLPPMTRGDSL 452 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 + QHFT+PP RF+EA+LVK++E+ GIGRPSTYA+ + T++DRGYV ++ +R Sbjct: 453 GRKGIEANQHFTEPPPRFTEATLVKKMEELGIGRPSTYAATLQTLRDRGYVELDKKRLIP 512 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 + G +VT LE+ F + YDFTA +E+ LD+++ + EWKAVL F++ F + D+ Sbjct: 513 QDKGRLVTAFLEDFFNRYVEYDFTASLEDQLDKISAGDLEWKAVLRDFWNPFHEICDEVI 572 Query: 580 KDP---------EEGGMRPNQMVLTSIDCPTCGR----KMGIRTASTGVFLGCSGYALPP 626 K E D C + ++ ++ + G F+GCS Y Sbjct: 573 KRSNTEVLDALNETLKAHVFPDKEDGSDPRKCPKCDTGRLSLKVSRFGAFVGCSNYNKDK 632 Query: 627 KERCKTTINLVPENEVLNVLEGEDAE----TNALRAKRRCPKCGTAMDSYLIDPKRKL-H 681 K+ + N + + G D++ + + P+ G + + Sbjct: 633 KDGKEPNENPPHCDYTRQLTSGGDSDAGAAADGPQVLGIDPETGLEVSLRTGRFGPYVQL 692 Query: 682 VCGNNPTCDGYEIEEGEFRIK--------GYDGPIVECEKCGSEMHLKMGRFGKYMACTN 733 P + + + G + +GRFG ++ Sbjct: 693 GEEAKPKRSSLPRGWSVADLDLEKALQLLSLPREVGTHPEDGKTISAGLGRFGPFVLHDG 752 Query: 734 EECKNTRKI---------------LRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG 778 + + PL EL + G G Sbjct: 753 TYANLDSPDEVFSVGINRAVTLLAEKRAKGGGRGAAAKPLKELGDHPDGGAINVYSGRYG 812 Query: 779 VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYL 814 ++ K + A L +++ L + + + Sbjct: 813 PYV------KWEKINATLPKDVAPEAVTLEQAIELV 842 >UniRef50_D0KVS8 DNA topoisomerase n=6 Tax=Gammaproteobacteria RepID=D0KVS8_HALNC Length = 834 Score = 651 bits (1680), Expect = 0.0, Method: Composition-based stats. Identities = 276/815 (33%), Positives = 403/815 (49%), Gaps = 83/815 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESPAKAKTI KYLG Y V +S GH+RDL Sbjct: 1 MSQTLVIVESPAKAKTIKKYLGPGYEVLASYGHVRDLIPKDG------------------ 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VD H++ +Y ++ + V +K+ + +D + LATD DREGEAI+ Sbjct: 43 -----------AVDTAHDFAMNYTLIDKNVRHVDAIKKALKSSDILLLATDPDREGEAIS 91 Query: 121 WHLREVIGG----DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WHLRE++ + RVVF EITK A+++A P +L+ID +NAQQARR +D +VG Sbjct: 92 WHLRELLAEAGLLKNKTAQRVVFYEITKKAVQEAVAHPRDLSIDLINAQQARRALDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALA- 235 + +SPLLWKKI GLSAGRVQS A+RL+VERE EI+AF P+E+W + A + Sbjct: 152 FNLSPLLWKKINPGLSAGRVQSPALRLIVEREAEIEAFNPQEYWTILADCQADRAAEKSR 211 Query: 236 -----LQVTHQNDKPFRPVNKEQTQAAVSLLEKARY---SVLEREDKPTTSKPGAPFITS 287 L + Q + F N+ Q+A S + +A +V E + P PF TS Sbjct: 212 FNARLLTLDGQKAEQFTLTNETDAQSARSRILEAAAGTLTVRSVEKRERKRNPAPPFTTS 271 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYI 339 TLQQ +LG + M +AQ LYE G ITYMRTD+ LS+DA+ +R +I Sbjct: 272 TLQQEGVRKLGLSASRVMRLAQELYEGVDIGAGTVGLITYMRTDAVTLSEDALTQIRAHI 331 Query: 340 SDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQ 397 D +G YLP SPN+Y +K +N+QEAHEAIRP+ +S++ + D +LY++I+++ Sbjct: 332 GDKYGAAYLPASPNRYKTKSKNAQEAHEAIRPTSAAHTPDSVRAFLNKDQFRLYEMIFKR 391 Query: 398 FVACQMTPAKYDSTTLTVGAGD-FRLKARGRILRFDGWTKVMPALRKG-----DEDRILP 451 VA QMTPA YD ++ + D +A G L+F G+ + DEDR LP Sbjct: 392 AVASQMTPAVYDQVSVDLAVNDQHSFRANGSTLKFPGFIALYREDEDDASGDNDEDRRLP 451 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR 511 + GD + L ++ QHFT+PP RF+EASLVK LE+ GIGRPSTYASIIST+Q R YV Sbjct: 452 PLTVGDKIALNDIAADQHFTEPPPRFTEASLVKTLEEYGIGRPSTYASIISTLQAREYVL 511 Query: 512 VENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 ++ RRF MG +V L + FR++++Y+FTA++E+ LD V+ E +W ++ F++ F Sbjct: 512 LDQRRFKPTDMGRVVNGFLTDYFRDIVDYEFTAKLEDDLDAVSRGERDWVPLMREFWTPF 571 Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG--------CSGYA 623 +++ E + P G+ + +R G F +A Sbjct: 572 HDRVEHTN---ENVTRQEAAQGRELGIDPKSGKPVSVRLGRFGPFAQIGTKDDEEKPKFA 628 Query: 624 LPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVC 683 + + TI L ++ + + + G Sbjct: 629 SLKRSQSIATITLDEALDLFQLPRKLGETPEGEPVEVAIGRFG---PFVKFGKMYASLGK 685 Query: 684 GNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKIL 743 ++P IK + + + ++ GR+G Y+ Sbjct: 686 DDDPYTIELPRALEIIEIKKLAEKNRYITQFDNGVSVQNGRYGPYI-----------TDG 734 Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG 778 + P +DP L C A + A G Sbjct: 735 KKNAKIPKDKDPKSLTLEECVALLAAAPEKKSARG 769 >UniRef50_C0W9S2 DNA topoisomerase n=1 Tax=Acidaminococcus sp. D21 RepID=C0W9S2_9FIRM Length = 754 Score = 650 bits (1677), Expect = 0.0, Method: Composition-based stats. Identities = 292/767 (38%), Positives = 424/767 (55%), Gaps = 79/767 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESP K+KTI ++LG +Y VK+S+GH+RDLP S Sbjct: 1 MAN-LVIVESPTKSKTIGRFLGKNYTVKASMGHLRDLPKSQF------------------ 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 GVD H++E Y + GK ++ ELK LA+KAD IYLATD DREGEAIA Sbjct: 42 -----------GVDVDHDFEPKYINIRGKGDLIKELKTLAKKADKIYLATDPDREGEAIA 90 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL ++G D R+ F+EIT +A+++A P +++D+V+AQQ RR +DR+VGY +S Sbjct: 91 WHLGYLLGVDPESNCRISFHEITPHAVKEAIKHPAAIDMDKVDAQQTRRILDRIVGYKLS 150 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-EALALQVT 239 PLLW+KIA+GLSAGRVQSVAV+++ +R++EI AF P+E+W + T +VT Sbjct: 151 PLLWRKIAKGLSAGRVQSVAVKIICDRQKEIDAFEPQEYWTSSVTLTADKPSHKFTAEVT 210 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 + K N+E+ + L Y+V K +P APF TS+LQQ A RL F Sbjct: 211 KKEGKKLVIHNEEEARTVTKELLNQSYAVASSAVKDRIRRPIAPFTTSSLQQEAVKRLNF 270 Query: 300 GVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 KKTMM+AQ+LYE G ITYMRTDS +L+ AV +R YI + +G YLP+ Sbjct: 271 TTKKTMMLAQQLYEGIALEKRTPVGLITYMRTDSVHLASVAVAEIRNYIGEVYGDAYLPK 330 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 PN Y+S++N+QEAHEAIRP+ V + + +E D +LY+LIW + V+CQM P+ + Sbjct: 331 KPNVYSSRKNAQEAHEAIRPTSVMRTPDEVAPYLERDQLRLYRLIWERTVSCQMAPSVSE 390 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVMPALR-KGDEDRILPAVNKGDALTLVEL-TPA 467 TTL + G + L+A G ++ FDG+ +M G++ + +P + +G LTL+ + Sbjct: 391 VTTLIINGGPYELRASGSVVNFDGFLTLMDKKELAGEKTKKVPHLKEGTPLTLISVDDAI 450 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFT+PPA F+EA+LVKELE++GIGRPSTYA+II TI RGYV E ++ ++G Sbjct: 451 QHFTEPPAYFTEATLVKELEEKGIGRPSTYATIIQTILSRGYVAKEAKKVMPTELGMTTI 510 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 + L + F L++ F+A MEN LD ++ H+ + + VL F+ F ++L+ A E + Sbjct: 511 ELLTQYFPNLIDVPFSAHMENELDAISEHKTKKETVLKEFYGPFEKELEIA---DREIPV 567 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 +P +++++ + C CGR M ++T G FL C G+ C+ T Sbjct: 568 KPQEVIVSDVKCEKCGRMMVVKTGRHGKFLACPGFP-----ECRNTKPYY---------- 612 Query: 648 GEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGP 707 + CP CG + R + C + P C ++ Sbjct: 613 --------EKIGVACPLCGHDLIVRKTKTGRTFYGCSHYPECHFTSWDKPINET------ 658 Query: 708 IVECEKCGSEMHLKMGRFGKYM-ACTNEECKNTRKILRNGEVAPPKE 753 C CG M + R GK + C+N EC N+ + K Sbjct: 659 ---CPLCGHIMLEAVQRGGKVVHHCSNPECPNSGAKKSGLKKVSAKA 702 Score = 69.4 bits (168), Expect = 6e-10, Method: Composition-based stats. Identities = 25/175 (14%), Positives = 47/175 (26%), Gaps = 27/175 (15%) Query: 618 GCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK 677 S + + K + + E + + +C KCG M Sbjct: 535 AISEHKTKKETVLKEFYGPFEKELEIADREIPVKPQEVIVSDVKCEKCGRMMV-VKTGRH 593 Query: 678 RKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK-YMACTN-EE 735 K C P C + Y+ V C CG ++ ++ + G+ + C++ E Sbjct: 594 GKFLACPGFPECRNTKPY--------YEKIGVACPLCGHDLIVRKTKTGRTFYGCSHYPE 645 Query: 736 CKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFL-AANTFPKS 789 C T C + G + + P+ Sbjct: 646 CHFTSWDKP--------------INETCPLCGHIMLEAVQRGGKVVHHCSN-PEC 685 Score = 62.0 bits (149), Expect = 9e-08, Method: Composition-based stats. Identities = 24/115 (20%), Positives = 41/115 (35%), Gaps = 18/115 (15%) Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 +++ P K V + ++ CEK V++ G G FLA FP+ R T+ Sbjct: 554 FEKELEIADREIPVKPQEVIVSDVKCEKCGRMMVVKTGRHGKFLACPGFPECRNTKPYY- 612 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE-KDGKATGW 851 + P G+ +VR ++ + Y S + T W Sbjct: 613 ---EKIGVACPL-------------CGHDLIVRKTKTGRTFYGCSHYPECHFTSW 651 >UniRef50_B8EMQ0 DNA topoisomerase n=153 Tax=Alphaproteobacteria RepID=B8EMQ0_METSB Length = 977 Score = 650 bits (1677), Expect = 0.0, Method: Composition-based stats. Identities = 290/908 (31%), Positives = 419/908 (46%), Gaps = 122/908 (13%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +VIVESPAKAK+INKYLG Y V S GH+RDLP Sbjct: 3 VVIVESPAKAKSINKYLGKGYEVYPSYGHVRDLPAKDG---------------------- 40 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 VDP ++ ++V K ++E+ + + AD I LATD DREGEAI+WH+ Sbjct: 41 -------SVDPDADFAMLWDVDVKSAKRLNEIARAVKDADKIILATDPDREGEAISWHVL 93 Query: 125 EVIGGDD----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 EV+ RVVFN ITK+A+ +A P ++++ V+A ARR +D +VG+ +S Sbjct: 94 EVLKAKKVLKDKPVERVVFNAITKSAVLEAMQHPRQIDVALVDAYLARRALDYLVGFNLS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW+K+ SAGRVQSVA+RLV +RE EI+AFV E+W + A T + ++ Sbjct: 154 PVLWRKLPGARSAGRVQSVALRLVCDRELEIEAFVAREYWSIVAHLRTQADAPFTARLVG 213 Query: 241 QNDKPFRPVN---KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + K ++ + A + LE A + V E E KP P APF TSTLQQ AS +L Sbjct: 214 ADGKKITRLDVGTGAEAAAFKTDLENATFRVAEIEAKPAKRHPSAPFTTSTLQQEASRKL 273 Query: 298 GFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 GF +TM +AQRLYE G ITYMRTD +L+ +A+ R I+ FG Y+P Sbjct: 274 GFAPARTMQLAQRLYEGADIDGETVGLITYMRTDGVDLAPEAITSARSVIARQFGDAYVP 333 Query: 350 ESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 ++P +Y K +N+QEAHEAIRP+D+ + ++ +E D KLY+LIW + +A QM A+ Sbjct: 334 KAPRKYTVKAKNAQEAHEAIRPTDLARLPRAVARALEPDQAKLYELIWTRTIASQMESAE 393 Query: 408 YDSTTLTVG----AGDFRLKARGRILRFDGWTKVMPALR---KGDEDRILPAVNKGDALT 460 + TT+ + A L+A G+++RFDG+ K+ R DE LP + K + L Sbjct: 394 LERTTVDIEALAGARKLDLRATGQVVRFDGFLKLYQEGRDDEDDDESARLPDMAKDERLK 453 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 + QHFT+PP RF+EA+LVK +E+ GIGRPSTYAS ++ +++R YVR+E +R + E Sbjct: 454 RERIEADQHFTEPPPRFTEATLVKRMEELGIGRPSTYASTLAVLRERDYVRIEKKRLHPE 513 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF--------- 571 G +VT LE F + YDFTA +E LD+V+NHE +WK VL F+ DF Sbjct: 514 DKGRLVTAFLEAFFARYVGYDFTADLEEKLDRVSNHEIDWKQVLRDFWLDFSGALAGTKD 573 Query: 572 ---TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK-MGIRTASTGVFLGCSGYALPPK 627 T+ LD+ + P + CP+CG + ++ G F+GCS Y Sbjct: 574 LRTTEVLDRLNEILGPHIFPPKEDGSDPRGCPSCGEGKLSLKLGKFGAFIGCSNYP---- 629 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSY--------LIDPKRK 679 CK T L + E E +++ P G + K Sbjct: 630 -ECKFTRTLAAPDGA----EANGGERPGVKSLGVDPDSGEEITLRDGRFGVYVQQGEGEK 684 Query: 680 LHVCGNNPT-CDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKN 738 PT E + + + + +GR+G Y+ Sbjct: 685 PKRSSLPPTIAPADLTLEQAIALLSLPREVARHPESKEPIVAGIGRYGPYVQHGKTYANV 744 Query: 739 TRKILR-------------------NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGV 779 + G E ++ G G Sbjct: 745 AKDEDIISIGANRAIDLIVAKESGLTGRRFGASESAPARVLGEHPA-GGAVSVKAGRYGP 803 Query: 780 FLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQ------------QDPEGNKT 827 ++ + A L +E L + LA P G Sbjct: 804 YVT------HGKINATLPKEADPTTLTLEGAVALLAAKASGGGAPMQGRLLGDHPSGGPI 857 Query: 828 MVRFSRKT 835 VR R Sbjct: 858 TVRAGRFG 865 >UniRef50_B8E2F6 DNA topoisomerase n=1 Tax=Dictyoglomus turgidum DSM 6724 RepID=B8E2F6_DICTD Length = 696 Score = 648 bits (1671), Expect = 0.0, Method: Composition-based stats. Identities = 271/763 (35%), Positives = 399/763 (52%), Gaps = 85/763 (11%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+IVESPAKAKTI K LG ++ V +S GHIRDLP Sbjct: 5 KLIIVESPAKAKTIEKILGKEFKVLASYGHIRDLPEKE---------------------- 42 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +GVD +N++ Y +LP ++K++ +K L++KA+ +YLATD DREGEAIAWHL Sbjct: 43 -------LGVDIENNFKPKYVLLPSRKKIIDTIKDLSKKAEKLYLATDPDREGEAIAWHL 95 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 E + +++R+ F+EIT AI +A P E+++DRV AQQARR +DR+VGY +SPLL Sbjct: 96 VEELKLPKEKFTRIEFHEITPRAILEAIKNPREIDLDRVEAQQARRILDRLVGYELSPLL 155 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 W+K+ +GLSAGRVQSVA+R + ERE EI+ F+PEE+W + + L ++ D Sbjct: 156 WEKVRKGLSAGRVQSVALRFICEREEEIEKFIPEEYWYIYGEFRDEE-KVLYGKLILYKD 214 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 + N+++ + +L Y + + K P PFITSTLQQ AS R GF V K Sbjct: 215 EEVNVKNEQEVNKIIRILNCLDYRIDKVVIKEEKRTPPPPFITSTLQQEASKRFGFPVGK 274 Query: 304 TMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQY 355 TM +AQ LYE G ITYMRTDST ++ +A YI FGK+Y+ ++ Sbjct: 275 TMKIAQSLYEGVDIGNERIGLITYMRTDSTRIAPEAREEAVQYIESGFGKEYVG-KEHKE 333 Query: 356 ASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLT 414 K Q+AHEAIRP+ V E ++ + + K+Y+LIW +F+A QM A ++ + Sbjct: 334 KKKLGVQDAHEAIRPTSVFRDPEKIRKYLTDEQFKIYKLIWERFIASQMNHAIFEVVEIY 393 Query: 415 VGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAV----NKGDALTLVELTPAQHF 470 + GD+ ++G+ L+F G+ + + E++ + +G + L L P Q F Sbjct: 394 IKGGDYVFLSKGKKLKFAGFMSLYMEKEENGEEKDEVNIDYVPEEGKNVKLTTLIPRQFF 453 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP R++EA+LV+ LEK G+GRPSTYA+II T+++R YV V++R +G++V D L Sbjct: 454 TEPPPRYTEATLVRTLEKYGVGRPSTYATIIETLKERKYVEVKDRTLVPTTLGKVVNDFL 513 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 + F L++ FTA+ME LD++ + + + VL F+ F ++L+K K + Sbjct: 514 TKQFPHLIDVKFTARMEEDLDKIESGKVKAIEVLKKFYPAFKEELEKVSK----NIGKIQ 569 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 + T CP CG K+ IR G + CS Y CK T + E + Sbjct: 570 VIEKTDEICPLCGSKLVIRENKNGKYYACSRYP-----ECKYTKPIYEEAQ--------- 615 Query: 651 AETNALRAKRRCPKC-GTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV 709 RCP C G + K+ C N P C E Sbjct: 616 ---------GRCPLCGGVVVKKKAKKTKKTFWGCINYPECSFASPYE---------PLNE 657 Query: 710 ECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK 752 +C +CGS M G + C+N++C R K Sbjct: 658 KCPQCGSTMLKGNG----FKKCSNKDCNYIVWTGRRKRWKKSK 696 Score = 59.0 bits (141), Expect = 9e-07, Method: Composition-based stats. Identities = 10/61 (16%), Positives = 21/61 (34%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRF 803 K + + C + V+R+ G + A + +P+ + T+ E R Sbjct: 559 EKVSKNIGKIQVIEKTDEICPLCGSKLVIRENKNGKYYACSRYPECKYTKPIYEEAQGRC 618 Query: 804 R 804 Sbjct: 619 P 619 Score = 54.7 bits (130), Expect = 1e-05, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 54/172 (31%), Gaps = 41/172 (23%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKED 754 + +I+ + C CGS++ ++ + GKY AC+ ECK T+ I Sbjct: 563 KNIGKIQVIEKTDEICPLCGSKLVIRENKNGKYYACSRYPECKYTKPIYEEA-------- 614 Query: 755 PVPLPELPCEKSDAYFVLRDGAAGV--FLAANTFPKSRETRAPLVEELYRFRDRLPEKLR 812 + C V + F +P+ L EK Sbjct: 615 -----QGRCPLCGGVVVKKKAKKTKKTFWGCINYPECSFASPYEP---------LNEK-- 658 Query: 813 YLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYVDGKWVEGK 864 P+ TM++ + K S KD W+ +W + K Sbjct: 659 --------CPQCGSTMLKGNGFKK----CSNKDCNYIVWTG--RRKRWKKSK 696 >UniRef50_Q3SMS7 DNA topoisomerase n=8 Tax=Proteobacteria RepID=Q3SMS7_THIDA Length = 857 Score = 647 bits (1668), Expect = 0.0, Method: Composition-based stats. Identities = 284/862 (32%), Positives = 421/862 (48%), Gaps = 90/862 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP+K+K++ KYLG+DY + +S GH+RDL Sbjct: 1 MSK-LVIVESPSKSKSLKKYLGADYDILASYGHVRDLEP--------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 R G N+ Y+++ K V + + A+KAD + LATD DREGEAI+ Sbjct: 39 ---------RTGAVDTENFSMKYQIIERNAKHVDAIVKAAKKADEVLLATDPDREGEAIS 89 Query: 121 WHLREVIG--GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 WH+ E++ RV F EIT++AI+ A P E+ D V+AQQARR +D +VG+ Sbjct: 90 WHISEILKEKKVKTPMKRVAFYEITESAIQDAVRNPREIASDLVDAQQARRALDYLVGFN 149 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +SPLLWKKI+ GLSAGRVQS A+R++VERE EI+AFV E+W + + +A ++ Sbjct: 150 LSPLLWKKISPGLSAGRVQSPALRMIVEREEEIEAFVAREYWTLHLD-SHKGSQAFTAKL 208 Query: 239 THQNDKPFR---PVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 TH + ++ +++ ++ LE V+ E K P APF TSTLQQA Sbjct: 209 THFKGEKLDQFAVEHEARSKEWLATLESKDARVMRIEKKRRARNPAAPFTTSTLQQAGVR 268 Query: 296 RLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 +LG + M AQ+LYE G ITYMRTDS NL+Q+A+ +R Y+ NF K Y Sbjct: 269 QLGMTTDRVMRTAQQLYEGIDLGEGPVGLITYMRTDSVNLAQEAITDIRKYVGANFDKDY 328 Query: 348 LPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTP 405 LP QY +K +N+QEAHEA+RP+ V ++++ + D +LY+L+W++ VACQMT Sbjct: 329 LPPHAVQYKAKTKNAQEAHEAVRPTSVLRTPDAVRQFLTQDQARLYELVWKRTVACQMTA 388 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELT 465 A++D+ + G+ +A G+ L F G+ V + + LPA+ +G+ L + L Sbjct: 389 AQFDTVAADITVGEGTFRATGQTLAFAGFLAVYQDDEDDEGESKLPALVEGETLPVDRLY 448 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 QHFT+PP R++EASLVK LE+ GIGRPSTYASIIST+QDR YV +E +RF +G + Sbjct: 449 GEQHFTQPPPRYTEASLVKALEEYGIGRPSTYASIISTLQDREYVVLEKKRFQPTDVGRL 508 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 V L +F ++YDFTA++E+ LD V+N + W +L F+S F L Sbjct: 509 VNCFLTRHFSHYVDYDFTAKLEDKLDDVSNGKRVWSRLLGEFWSGFEGDLK--------A 560 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 + CP C + + ++ + G+F+GCSGY C T L P + Sbjct: 561 KQDVERGCPILEACPKCAKPLFMQASKRGLFIGCSGYP-----ECDYTRPLHPATAEGDN 615 Query: 646 LEGEDAETN---ALRAKRRCPKCG---TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF 699 + G+D + L + R P D P+R + Sbjct: 616 ILGKDPASGLDVKLLSGRFGPYVQIGDMPEDKKAPKPRRASWPKDI---PLENATLDLAL 672 Query: 700 RIKGYDGPIVECEKCGSEMHLKMGRFGKYM-------ACTNEECKNTRKIL--------R 744 + + G + GRFG Y+ + + + Sbjct: 673 KFLSLPREVGHHPTTGLPIVANNGRFGPYLLHDGKFKSIPKTDSVYEIDLPRALEVLAME 732 Query: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFR 804 V P + +R G G ++ K T A L +++ Sbjct: 733 RAPRGADSAASVLKNLGPHPEDGKDITVRSGRYGPYV------KHGSTNATLPKDITPEA 786 Query: 805 DRLPEKLRYLADAPQQDPEGNK 826 L E + +A + P Sbjct: 787 VTLDEAIGLIAARVAKGPAKKP 808 >UniRef50_Q47L55 DNA topoisomerase n=4 Tax=Actinomycetales RepID=Q47L55_THEFY Length = 906 Score = 645 bits (1663), Expect = 0.0, Method: Composition-based stats. Identities = 296/857 (34%), Positives = 404/857 (47%), Gaps = 101/857 (11%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LVIVESPAKAKTI YLG Y+V+SS+GHIRDLP + Sbjct: 20 GNKLVIVESPAKAKTIAGYLGPGYIVESSIGHIRDLPNKAAEIPARY------------- 66 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + R+GV+ ++E Y V K+ V LK+L +AD +YLATD DREGEAIAW Sbjct: 67 --KDEPWARLGVNVDRDFEPLYVVNADKKAQVKRLKELLAEADELYLATDEDREGEAIAW 124 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HLRE + R+VFNEITK AIR A +LN+ V+AQ+ RR +DR+ GY VSP Sbjct: 125 HLREELKP-TIPVKRMVFNEITKEAIRHAAQHTRDLNLRLVDAQETRRILDRLYGYEVSP 183 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST--------------- 226 +LWKK+ LSAGRVQSVA RLVVERERE AF P E+W + A Sbjct: 184 VLWKKVMPSLSAGRVQSVATRLVVERERERIAFTPAEYWGLKAVFAVLTGTDGADPTTFP 243 Query: 227 ---------TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTT 277 G Q ++ K R +++E + L A+Y+V E KP Sbjct: 244 ATLATVDGDRVAQGRDFTSQGVLRSPKGVRHLDEETARGLAERLAGAQYTVRSVERKPYR 303 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 P APF T+TLQQ AS +LG K+TM +AQRLYE GYITYMRTDST LS+ A+ R Sbjct: 304 RSPYAPFRTTTLQQEASRKLGLSAKQTMQVAQRLYENGYITYMRTDSTTLSESAIAAARA 363 Query: 338 YISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWR 396 ++ +G YLP+ P Y SK +N+QEAHEAIRP+ + + +LY+LIW+ Sbjct: 364 QVARLYGDNYLPDKPRTYTSKVKNAQEAHEAIRPAGDTFRTPAETGLSGVELRLYELIWK 423 Query: 397 QFVACQMTPAKYDSTTLTVGA-----GDFRLKARGRILRFDGWTKVM------PALRKGD 445 + +A QM A +S ++ V A G+I+ F G+ K P D Sbjct: 424 RTIASQMKDAVGESVSVRVAGTSTAGEQVEFSATGKIITFHGFLKAYVEGTDDPQAELDD 483 Query: 446 EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQ 505 +R LP + +GD L + H T+PPAR++EASLVKELE+R IGRPSTYA+II TI Sbjct: 484 RERRLPPLTEGDPLHAQSVDAEGHSTRPPARYTEASLVKELEEREIGRPSTYATIIGTIL 543 Query: 506 DRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD 565 +RGYV + + V LE +F L++YDFTA+ME+ LD +A EAE L Sbjct: 544 ERGYVFKKGSALVPSFLAFAVVQLLERHFSHLVDYDFTARMEDVLDAIARGEAERVPWLR 603 Query: 566 HFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALP 625 F+ Q+ E E G P + +R G +L +G + Sbjct: 604 RFYFGADGQIGLKELVNEHLGD---IDPKEISSFPLPDSDIVLRVGRYGPYLERNGQRVN 660 Query: 626 PKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLH---- 681 + +L P+ E A+ N R + P+ G + + + Sbjct: 661 VPD------DLAPDELTKERAEELFAQPNGDRELGKDPETGRTIVAKNGRFGPYVTEVIE 714 Query: 682 --------------VCGNNPTCDGYEIEEGE--------FRIKGYDGPIVECEKCGSEMH 719 P + + +K P V E G ++ Sbjct: 715 ETEAEAEEAKPKGRKKTAAPKPRTASLLKSMSLETITLEDALKLLSLPRVVGEIDGEQVT 774 Query: 720 LKMGRFGKYMA-------CTNEECKNTRKILRNGEVAPPKED-------PVPLPELPCEK 765 + GRFG Y+ EE T I E+ + P P Sbjct: 775 AQNGRFGPYLKKGSESRSLETEEQLFTVTIEEAKELFAQPKKRRTRAAAPPLRELGPDPV 834 Query: 766 SDAYFVLRDGAAGVFLA 782 + V+++G G ++ Sbjct: 835 TGKPMVIKEGRFGPYVT 851 >UniRef50_B1M0P4 DNA topoisomerase n=14 Tax=Alphaproteobacteria RepID=B1M0P4_METRJ Length = 894 Score = 641 bits (1654), Expect = 0.0, Method: Composition-based stats. Identities = 289/896 (32%), Positives = 423/896 (47%), Gaps = 116/896 (12%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 +V+VESPAKAKTINKYLG DY V +S GHIRDLP Sbjct: 2 KVVVVESPAKAKTINKYLGRDYEVIASFGHIRDLPPKDG--------------------- 40 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 VDP ++ +E+ VSE+ + + AD + LATD DREGEAI+WH+ Sbjct: 41 --------SVDPEQDFRMVWELADRGASRVSEIAKAVKGADKLILATDPDREGEAISWHV 92 Query: 124 REVIGGDDA----RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 E + A RV FN ITK ++ QA KP E++ V+A ARR +D +VG+ + Sbjct: 93 LEALTARKALKGIPVERVTFNAITKASVEQAMRKPREIDQALVDAYLARRALDYLVGFNL 152 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP+LW+K+ SAGRVQSVA+RLVVERE EI+ F P E+W + A+ TT G ++ Sbjct: 153 SPVLWRKLPGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEARLV 212 Query: 240 HQNDKPFRPVN---KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 + K + ++ E+ A LE A + V E KP P PF TSTLQQ AS + Sbjct: 213 GADGKRIQRLDVGTGEEAAAFRRDLELATFQVASVEAKPAKRHPQPPFTTSTLQQEASRK 272 Query: 297 LGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LG +TM +AQRLYE G ITYMRTD +++ +A+ R I FG +Y+ Sbjct: 273 LGMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDARRVIGKEFGDRYV 332 Query: 349 PESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPA 406 P+ P +Y+ K +N+QEAHEA+RP+D+ + +++ +E + +LY+LIW + +A QM A Sbjct: 333 PDVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIWTRTMASQMESA 392 Query: 407 KYDSTTLTVGAG----DFRLKARGRILRFDGWTKVMPALRKGDE---DRILPAVNKGDAL 459 + + TT+ V A L+A G++++FDG+ + + +E R LP + GD L Sbjct: 393 ELERTTVDVTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPPMKAGDPL 452 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 T ++ QHFT+PP R+SEASLVK +E+ GIGRPSTYA+++ T++DR YV++E +R Sbjct: 453 TRERISATQHFTEPPPRYSEASLVKRMEELGIGRPSTYAAVLQTLRDREYVKIEKKRLQP 512 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 E G +VT LE FR + YDFTA +E LD+V+N E +W+AVL F+ DF+ + + + Sbjct: 513 EDKGRLVTGFLESFFRRYVEYDFTAGLEEQLDRVSNAEIDWRAVLRDFWRDFSAAIGETK 572 Query: 580 KDPE------------EGGMRPNQMVLTSIDCPTCGRK-MGIRTASTGVFLGCSGYALPP 626 + CPTCG + ++ G F+GCS Y Sbjct: 573 ELRVADVLEALNGLLGPHIFPDKGDGSNPRTCPTCGSGQLSLKLGKFGAFIGCSNYP--- 629 Query: 627 KERCKTTINL-VPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLI----------- 674 CK T L + + +R P G + Sbjct: 630 --ECKYTRQLSATGIDGDGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFLQLGEA 687 Query: 675 -------DPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK 727 PKR G +P+ + + + G + +GRFG Sbjct: 688 STEKGAEKPKRSSLPKGLSPS---DVDLNKALALLALPREVARHPETGEPILANLGRFGP 744 Query: 728 YMACTNEECKNTRKI----------------LRNGEVAPPKEDPVPLPELPCEKSDAYFV 771 Y+ + G P E S V Sbjct: 745 YVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRLAADPGRPLGKDEASGRDLV 804 Query: 772 LRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKT 827 ++ G G ++ E A L + + L E + + +A + G Sbjct: 805 VKAGKYGPYVTDG------EVNATLPKTMSAEALTLDEAIALV-NAKRAAGGGKPA 853 Score = 61.3 bits (147), Expect = 2e-07, Method: Composition-based stats. Identities = 34/140 (24%), Positives = 52/140 (37%), Gaps = 15/140 (10%) Query: 711 CEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKE------DPVPLPELP 762 C CG ++ LK+G+FG ++ C+N ECK TR++ G P Sbjct: 604 CPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSATGIDGDGDGSSAEGGQPGVRVLGD 663 Query: 763 CEKSDAYFVLRDGAAGVFL--AANTFPKS--RETRAPLVEELYRFRDRLPEKLRYLA--- 815 + LRDG G FL + K + R+ L + L L + L LA Sbjct: 664 DPATGLPVTLRDGRFGPFLQLGEASTEKGAEKPKRSSLPKGLSPSDVDLNKALALLALPR 723 Query: 816 DAPQQDPEGNKTMVRFSRKT 835 + + G + R Sbjct: 724 EVARHPETGEPILANLGRFG 743 >UniRef50_B2KBN6 DNA topoisomerase n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KBN6_ELUMP Length = 765 Score = 640 bits (1650), Expect = 0.0, Method: Composition-based stats. Identities = 290/797 (36%), Positives = 420/797 (52%), Gaps = 91/797 (11%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK LVIVESP K KTI+K LG+DYVVKSS GH+RDLP+ Sbjct: 17 GKNLVIVESPTKQKTISKILGADYVVKSSFGHVRDLPSKE-------------------- 56 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +GVD + ++ Y + +K+VSEL++LA+ ++++YLATD DREGEAIAW Sbjct: 57 ---------IGVDEKNGFKPKYVPVEKAKKMVSELEKLAKGSEYVYLATDPDREGEAIAW 107 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL E++ + R+ F+EIT A++ +F+ +N D V+AQQARR +DR+VGY +SP Sbjct: 108 HLVELLKIPVEKIRRIFFHEITPAAVKASFDHARNINKDLVDAQQARRVLDRLVGYKLSP 167 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT----PSGEALALQ 237 LLWKKI GLSAGRVQSVAVRL+ ER +EI+ F EE++ + + P A L+ Sbjct: 168 LLWKKITGGLSAGRVQSVAVRLLAERAKEIENFREEEYYSLTSELEKQGETPKFNARMLK 227 Query: 238 VTHQNDKPFR---------------PVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 +N + E SLL + +V + E K K Sbjct: 228 WRGKNTEIITTYHLFAEDYKVKTTVFKKPEDLAPVNSLLRQGPLTVSKIEKKEVKQKAKP 287 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNM 334 PFITS+LQQ A ++GF +KTMM AQ LYE G ITYMRTDS N+S+D + Sbjct: 288 PFITSSLQQEAYNKIGFPSQKTMMTAQSLYEGVEIAGEVVGLITYMRTDSFNVSKDLQSQ 347 Query: 335 VRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQ 392 + +I+ +G ++P +PN + SK + +QEAHE+I P+DV S+KD + AD KLY+ Sbjct: 348 TKKFIAGKYGDDFVPPTPNFFKSKVKGAQEAHESIHPTDVYKTPASIKDYLSADQYKLYE 407 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFR---LKARGRILRFDGWTKVMPALRKGDE--- 446 LIW +F+A QM A +++ ++ + AG L+A GR ++F G+ V +E Sbjct: 408 LIWLRFIASQMADAVFNTVSVDITAGKAEECVLRATGRTVKFPGFLSVYKEDDSEEEDEG 467 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506 +LP + +GD L L+++ H T PP ++EASL+K LEK GIGRPSTYA I TI D Sbjct: 468 SALLPNLTEGDDLNLIDIVTKSHKTAPPPNYNEASLIKTLEKHGIGRPSTYAPTIKTILD 527 Query: 507 RGYVRVENR--RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 R Y+ + + + +G VTD+L++ F+++M+ +TA +E LD +A + +W V+ Sbjct: 528 RKYIIRQPKTNKLIVTDLGVTVTDQLKDFFKDIMDLSYTAGIEEKLDDIAEGDNDWVKVI 587 Query: 565 DHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYAL 624 F+ F + L A+KD + +P + CP CG M IR + G +L CS Y Sbjct: 588 GDFYEGFKKDLATADKDMQRAAPKP-----SDEKCPLCGSPMVIRRSRFGEYLACSTYP- 641 Query: 625 PPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCG 684 CK INL E L + +C KCG+ M + K C Sbjct: 642 ----ECKGKINLTSSGEKL----------APEVTEEKCEKCGSPMVIR-SGRRGKFMACS 686 Query: 685 NNPTCDGYEIEEGEFRI---KGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTR 740 P C + G ++CEKCG M L+ + G+++ C+ +CK Sbjct: 687 AFPKCKNTFSIDASGNKVASSGPIETKIKCEKCGKPMLLRASKRGEFLGCSGYPKCKTIV 746 Query: 741 KILRNGEVAPPKEDPVP 757 + KE Sbjct: 747 SVSPEEIAKIKKEHEAE 763 Score = 127 bits (319), Expect = 2e-27, Method: Composition-based stats. Identities = 42/167 (25%), Positives = 67/167 (40%), Gaps = 4/167 (2%) Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF 699 + L + + + +CP CG+ M + C P C G Sbjct: 595 KKDLATADKDMQRAAPKPSDEKCPLCGSPMVIRRSRFG-EYLACSTYPECKGKINLTSSG 653 Query: 700 RIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPL 758 + +CEKCGS M ++ GR GK+MAC+ +CKNT I +G Sbjct: 654 EKLAPEVTEEKCEKCGSPMVIRSGRRGKFMACSAFPKCKNTFSIDASGN--KVASSGPIE 711 Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRD 805 ++ CEK +LR G FL + +PK + + EE+ + + Sbjct: 712 TKIKCEKCGKPMLLRASKRGEFLGCSGYPKCKTIVSVSPEEIAKIKK 758 Score = 89.0 bits (219), Expect = 8e-16, Method: Composition-based stats. Identities = 38/152 (25%), Positives = 60/152 (39%), Gaps = 23/152 (15%) Query: 704 YDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 +C CGS M ++ RFG+Y+AC+ ECK + +GE P + E Sbjct: 610 PKPSDEKCPLCGSPMVIRRSRFGEYLACSTYPECKGKINLTSSGEKLAP-----EVTEEK 664 Query: 763 CEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDP 822 CEK + V+R G G F+A + FPK + T + P Sbjct: 665 CEKCGSPMVIRSGRRGKFMACSAFPKCKNTFSIDASGNK---------------VASSGP 709 Query: 823 EGNKTMVRFSRKTKQQYVSSEKDGKATGWSAF 854 K ++ + K + + K G+ G S + Sbjct: 710 IETK--IKCEKCGKPMLLRASKRGEFLGCSGY 739 Score = 62.8 bits (151), Expect = 6e-08, Method: Composition-based stats. Identities = 14/89 (15%), Positives = 29/89 (32%), Gaps = 9/89 (10%) Query: 748 VAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRL 807 + + C + V+R G +LA +T+P+ + + Sbjct: 602 DKDMQRAAPKPSDEKCPLCGSPMVIRRSRFGEYLACSTYPECKGKINLTSSGEKLAPEVT 661 Query: 808 PEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 EK + G+ ++R R+ K Sbjct: 662 EEK---------CEKCGSPMVIRSGRRGK 681 >UniRef50_C1D174 DNA topoisomerase n=34 Tax=cellular organisms RepID=C1D174_DEIDV Length = 966 Score = 639 bits (1648), Expect = 0.0, Method: Composition-based stats. Identities = 285/879 (32%), Positives = 412/879 (46%), Gaps = 82/879 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESPAKA+TI KYLG Y V+SS+GHIRDLP S S + Sbjct: 1 MARTLVIVESPAKARTIEKYLGKGYAVESSIGHIRDLPKSASDIPEKY------------ 48 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +G R+G+D ++++ Y V P K + V++L++LA AD I LATD DREGE+IA Sbjct: 49 ---KGKAWARLGLDIENDFQPLYVVAPDKRQHVAKLRKLAADADEIILATDDDREGESIA 105 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL + + R+VF+EITK AI+ A P +++ + V AQ+ARR +DR+ GY VS Sbjct: 106 WHLFQELKP-KVPVKRMVFHEITKEAIQAAIAHPRQIDTNLVEAQEARRALDRLYGYEVS 164 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+A LSAGRVQSVA R++VERERE FV +W++ + T G+ ++T Sbjct: 165 PVLWKKVAPKLSAGRVQSVATRMLVERERERMRFVSATWWDLLVTGKTGDGQTFPARLTD 224 Query: 241 -------------------QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 + R + + + QA + L +V E+KP T +P Sbjct: 225 VGGQRLAAGKDFDPLTGRLKEGAAVRLLTEAEAQALTAGLTGQALTVTSAEEKPFTQRPY 284 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 APFITSTLQQ S +LGF +TM AQ+LYE GYITYMRTDSTNLS +AV R ++ Sbjct: 285 APFITSTLQQEGSRKLGFAATRTMRAAQKLYEGGYITYMRTDSTNLSVEAVTAARTQVTQ 344 Query: 342 NFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLYQLIWRQF 398 +G +L P YA K +N+QEAHEAIRP+ + ++ D +LY LIW++ Sbjct: 345 MYGPAFLHPQPRVYAKKAKNAQEAHEAIRPAGSSFRTPDSLRGELGGDEWRLYDLIWKRT 404 Query: 399 VACQMTPAKYDSTTLTV---GAGDFR--LKARGRILRFDGWTKVM------PALRKGDED 447 VA QM A+ S + + G L A GR + F G+ + P D D Sbjct: 405 VASQMADARGRSLRVRLGGQAQGGETVGLSASGRTIDFPGFLRAYVEGSDDPNAALEDRD 464 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 LP + +G +T + P H T+PPAR++EASLV+ LE GIGRPSTYASI+ TIQDR Sbjct: 465 TPLPPLKEGQQVTAETVRPESHETQPPARYTEASLVQALEAAGIGRPSTYASILGTIQDR 524 Query: 508 GYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 GY + + + LE +F +L++YDFTA+ME LD +A A L F Sbjct: 525 GYATKKGQALVPTWTAFATSALLEHHFGKLVDYDFTARMEEDLDDIAGGRASRVPYLRRF 584 Query: 568 FSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPT-CGRKMGIRTASTGVFLGCSGYALPP 626 + Q + + + + +I P G + +R G Y Sbjct: 585 YLGDEGQGMALKPLIDRQMGEIDARGIATIHVPKLDGTGIEVRVGRYGP------YMQRG 638 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNN 686 +++ LVP+ V E + + R G + + + + +N Sbjct: 639 EDKANLPEGLVPDELTAEVAEDLMSRPSGDRVIGTDEASGHPVVARAGRYGPYVTLGDSN 698 Query: 687 PTCDGY--------EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA------CT 732 P E ++ P + G E+ G++G Y+ Sbjct: 699 PPVRSASLFPGDDLNTLTMERALRLLSLPRLVGVSEGEEVWAMNGKYGPYLKRGGDSRSL 758 Query: 733 NEECKNTRKILRNGEVAPPKEDPVPLPELPCE------KSDAYFVLRDGAAGVFLAANTF 786 N + L E + + +L+ G G +L Sbjct: 759 NSHEELFTVGLHEAEALFMQPRFRARGVAAAPLRTFEFEGRPPILLKSGRFGPYLTDG-- 816 Query: 787 PKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGN 825 E A L + L L + ++ + Sbjct: 817 ----ERNATLRKGEDEDNLTPERALEILEERGKEPKKKA 851 >UniRef50_B1VM20 DNA topoisomerase n=6 Tax=Streptomyces RepID=B1VM20_STRGG Length = 963 Score = 638 bits (1646), Expect = 0.0, Method: Composition-based stats. Identities = 294/866 (33%), Positives = 411/866 (47%), Gaps = 103/866 (11%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ LVIVESPAKAKTI YLG YVV++SVGHIRDLP + Sbjct: 11 GRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPNGAAEVP---------------- 54 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 DE V R+GVD H+++ Y V K+ V +LKQL ++D ++LATD DREGEAIAW Sbjct: 55 DEYTGEVRRLGVDVEHDFQPIYVVNADKKAQVRKLKQLLAESDELFLATDEDREGEAIAW 114 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL+EV+ R+VF+EITK+AIR A P ELN V+AQ+ RR +DR+ GY VSP Sbjct: 115 HLQEVLRP-KVPVHRMVFHEITKDAIRAAVANPRELNQRMVDAQETRRILDRLYGYEVSP 173 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP------SGEALA 235 +LWKK+ LSAGRVQSVA RLVVERERE AF E+W++ T L Sbjct: 174 VLWKKVMPKLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGKFATGRTGDASDPSNLT 233 Query: 236 LQVTHQNDKPF-------------------RPVNKEQTQAAVSLLEKARYSVLEREDKPT 276 +++ + + +++ +A + L + ++V E KP Sbjct: 234 ARLSAVDGRRIAQGRDFGPDGQLKAGSAQTLHLDETNARALAAALADSSFTVRSVESKPY 293 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 P APF T+TLQQ AS +LGFG K TM +AQ+LYE G+ITYMRTDST LS AV R Sbjct: 294 RRSPYAPFRTTTLQQEASRKLGFGAKATMQVAQKLYENGFITYMRTDSTTLSDTAVAAAR 353 Query: 337 GYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 ++ +G YLPE P YA K +N+QEAHEAIRPS + + D +LY+LIW Sbjct: 354 AQVTQLYGASYLPEKPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFRLYELIW 413 Query: 396 RQFVACQMTPAKYDSTTLTV-----GAGDFRLKARGRILRFDGWTKVM------PALRKG 444 ++ VA QM A +S T+ + D A G+ + F G+ K P Sbjct: 414 KRTVASQMKDATGNSVTVKIGGRASDGRDAEFSASGKTITFHGFMKAYVEGADDPNAELD 473 Query: 445 DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTI 504 D +R LP V +GDAL+ E+T H TKPPAR++EASLVKELE+R IGRPSTYASII TI Sbjct: 474 DRERRLPQVAEGDALSADEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTI 533 Query: 505 QDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 DRGYV + + V + LE++F L++YDFTA+ME+ LD+++ EA+ L Sbjct: 534 LDRGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRISRGEAQSVPWL 593 Query: 565 DHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID---------------CPTCGRKMGIR 609 F+ D A + L + G + +R Sbjct: 594 KRFYFGADAGDDTAGAGSASDAGNGDGDHLGGLKALVTDLGAIDAREISSFPVGNDIKLR 653 Query: 610 TASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAM 669 G ++ +R +L P+ + + E A+ + P G + Sbjct: 654 VGRYGPYIERGEKDAEGHQRADVPEDLAPDELTVELAEELLAKPSGDFELGADPATGNQI 713 Query: 670 DSYLIDPKRKLH--VCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC------------- 714 + + + P ++ + Sbjct: 714 IAKDGRYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLADALKLMSLPRVVGE 773 Query: 715 ---GSEMHLKMGRFGKYMACTNEECKNTRKIL---------------RNGEVAPPKEDPV 756 G E+ + GR+G Y+ + ++ + + P Sbjct: 774 DAEGVEITAQNGRYGPYLK-KGTDSRSLTSEDQLFDITLEEALAIYAQPKQRGRAAAKPP 832 Query: 757 PLPELPCEKSDAYFVLRDGAAGVFLA 782 S A V++DG G ++ Sbjct: 833 LKELGTDPVSGAPVVVKDGRFGAYVT 858 >UniRef50_Q9X909 DNA topoisomerase 1 n=14 Tax=cellular organisms RepID=TOP1_STRCO Length = 952 Score = 638 bits (1646), Expect = 0.0, Method: Composition-based stats. Identities = 294/860 (34%), Positives = 411/860 (47%), Gaps = 96/860 (11%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ LVIVESPAKAKTI YLG YVV++SVGHIRDLP+ + + Sbjct: 11 GRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPSGAAEVPEKYTGEV--------- 61 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 R+GVD H+++ Y V K+ V +LK L +++D ++LATD DREGEAIAW Sbjct: 62 -------RRLGVDVEHDFQPIYVVNADKKSQVKKLKDLLKESDELFLATDEDREGEAIAW 114 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL+EV+ R+VF+EITK+AIR A P ELN V+AQ+ RR +DR+ GY VSP Sbjct: 115 HLQEVLKP-KIPVKRMVFHEITKDAIRAAVANPRELNQKLVDAQETRRILDRLYGYEVSP 173 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP------SGEALA 235 +LWKK+ LSAGRVQSVA RLVVERERE AF E+W++ + T +L Sbjct: 174 VLWKKVMPRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAGDASDPSSLV 233 Query: 236 LQVTHQNDKPF-----------------RPVNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 ++ + + +++ +A + LE R++V E KP Sbjct: 234 ARLQTVDGRRVAQGRDFDSLGQLKSANTLHLDEANARALAAALENTRFAVRSVESKPYRR 293 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY 338 P APF T+TLQQ AS +LGFG K TM +AQ+LYE GYITYMRTDST LS AV+ R Sbjct: 294 SPYAPFRTTTLQQEASRKLGFGAKSTMQVAQKLYENGYITYMRTDSTTLSDTAVSAARAQ 353 Query: 339 ISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 ++ +G YLP P YA K +N+QEAHEAIRPS + + D KLY+LIW++ Sbjct: 354 VTQLYGADYLPPQPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKR 413 Query: 398 FVACQMTPAKYDSTTLTV-----GAGDFRLKARGRILRFDGWTKVM------PALRKGDE 446 VA QM A +S T+ + D A G+ + F G+ K P D Sbjct: 414 TVASQMKDATGNSVTVKIGGAASDGRDVEFSASGKTITFHGFLKAYVEGADDPNAELDDR 473 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506 +R LP V +GDALT E+T H TKPPAR++EASLVKELE+R IGRPSTYASII TI D Sbjct: 474 ERRLPQVAEGDALTAEEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILD 533 Query: 507 RGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 RGYV + + V + LE++F L++YDFTA+ME+ LD++A EA+ L Sbjct: 534 RGYVFKKGTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQSVPWLRR 593 Query: 567 FFSDFTQQLDKAEKDPEEGGMRPN------------QMVLTSIDCPTCGRKMGIRTASTG 614 F+ G + + + G + +R G Sbjct: 594 FYFGEGDGTGGGGAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGNDIKLRVGRYG 653 Query: 615 VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLI 674 ++ +R +L P+ + + E A+ + P G A+ + Sbjct: 654 PYVERGEKDAENHQRADVPEDLAPDELSVELAEELLAKPSGDFELGTDPATGHAIVAKDG 713 Query: 675 DPKRKLH--VCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC----------------GS 716 + + P ++ + G Sbjct: 714 RYGPYVTEVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLDDALKLMSLPRVVGADAEGV 773 Query: 717 EMHLKMGRFGKYMA-------CTNEECKNTRKILRN-------GEVAPPKEDPVPLPELP 762 E+ + GR+G Y+ E+ + + P Sbjct: 774 EITAQNGRYGPYLKKGTDSRSLQTEDQLFEITLEEALAIYAQPKQRGRAAAKPPLKELGT 833 Query: 763 CEKSDAYFVLRDGAAGVFLA 782 S+ V++DG G ++ Sbjct: 834 DPVSEKPVVVKDGRFGPYVT 853 >UniRef50_B0VJB5 DNA topoisomerase n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VJB5_9BACT Length = 739 Score = 637 bits (1643), Expect = 0.0, Method: Composition-based stats. Identities = 276/807 (34%), Positives = 401/807 (49%), Gaps = 89/807 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKA TI+K+L + + VK+S+GHIRDLP Sbjct: 1 MSKGLIIVESPAKAGTISKFLKNQFSVKASMGHIRDLPKRE------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GV+ ++ Y + K KV++ELK+ AD +YLA+D DREGEAIA Sbjct: 42 ----------LGVNVHQGFKPVYIIDKTKSKVIAELKEATLSADSVYLASDNDREGEAIA 91 Query: 121 WHLREVIGG--DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 WHL E + ++ R+VFNEIT AI +A PG++++ +V AQQARR +DR+VGY Sbjct: 92 WHLSETLKKELNNKPVYRIVFNEITSQAINEAIKNPGQIDMAKVEAQQARRILDRLVGYE 151 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +SPLLWK I + LSAGRVQSVA+RL+ ERE EIKAFVP+E+W+++A + + Sbjct: 152 ISPLLWKVITKDLSAGRVQSVALRLICEREAEIKAFVPKEYWKIEADFWKDNLPPFKAVL 211 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 K +++ V + A + E + +P PFITSTLQQ AS LG Sbjct: 212 EKIEGKKVEIPDEKSAIEIVENSQNAEAILSEIKRSNRNVEPLPPFITSTLQQEASKILG 271 Query: 299 FGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 F +KTM +AQ LYE G ITYMRTDST ++++A+ + I + FGK+ + Sbjct: 272 FQAQKTMSIAQVLYEGIDLGGERTGLITYMRTDSTRMAEEAITKAQNLIKERFGKELVHP 331 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 + +K+++Q+AHEAIRP+D ES+ + + KLY LIW++F+A QM P K Sbjct: 332 KVRVFKNKQSAQDAHEAIRPTDPFRTPESVAQYLTKEQMKLYTLIWQRFIATQMIPVKLL 391 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 ST++ + AG + G + +G+ K P L ++I K D L L QH Sbjct: 392 STSVKINAGKAEFVSSGAQIMEEGFLKAYPHLYIPLGEKIHQDYAKNDVLEHSPLEKTQH 451 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FT PAR++EASL+KELE +GIGRPSTYA+II T++ R YV +E + F ++G V Sbjct: 452 FTTSPARYTEASLIKELEAKGIGRPSTYATIIETLRKRKYVTMEKKAFLPTQLGSDVNRF 511 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 L + F L N FTA+ME LD+V W V+ ++ + + + E + Sbjct: 512 LVDKFDYLFNVQFTAEMETKLDEVEYSNIAWNEVVQEYYDQLVALIRQVDVKKE----KN 567 Query: 590 NQMVLTSIDCPTCGRK-MGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 N + T I C C + M I+ + G FL CS + +CK T N + + G Sbjct: 568 NFVQDTGIVCDVCKQGTMLIKHSKRGDFLSCSRFP-----QCKNTKNFTRDED------G 616 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 CP+CG+ + + C N P C Sbjct: 617 NIKIFVPTPLNENCPQCGSPLMLR-TGKYGEFIACSNYPKCKYARP----------KTLG 665 Query: 709 VECEKCG-SEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 ++C +CG E+ + + G+ + +C ECK + C K Sbjct: 666 IKCPECGIGELTARKSKKGRTFYSCNRYPECKYITNDKP--------------LPISCPK 711 Query: 766 SDAY-FVLRDGA-AGVFLAANTFPKSR 790 V + G P + Sbjct: 712 CGNPYIVEKYSREKGKIKIC---PNCK 735 Score = 94.4 bits (233), Expect = 2e-17, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 48/157 (30%), Gaps = 22/157 (14%) Query: 648 GEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE----EGEFRIKG 703 ++ C C + C P C + +G +I Sbjct: 563 KKEKNNFVQDTGIVCDVCKQGTMLIKHSKRGDFLSCSRFPQCKNTKNFTRDEDGNIKIFV 622 Query: 704 YDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 C +CGS + L+ G++G+++AC+N +CK R + Sbjct: 623 PTPLNENCPQCGSPLMLRTGKYGEFIACSNYPKCKYARP---------------KTLGIK 667 Query: 763 CEKSD-AYFVLRDGAAGV-FLAANTFPKSRETRAPLV 797 C + R G F + N +P+ + Sbjct: 668 CPECGIGELTARKSKKGRTFYSCNRYPECKYITNDKP 704 Score = 78.6 bits (192), Expect = 9e-13, Method: Composition-based stats. Identities = 30/140 (21%), Positives = 62/140 (44%), Gaps = 11/140 (7%) Query: 707 PIVECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCE 764 + C+ C M +K + G +++C+ +CKNT+ R+ + P PL C Sbjct: 573 TGIVCDVCKQGTMLIKHSKRGDFLSCSRFPQCKNTKNFTRDEDGNIKIFVPTPL-NENCP 631 Query: 765 KSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEG 824 + + +LR G G F+A + +PK + R + PE + + + + Sbjct: 632 QCGSPLMLRTGKYGEFIACSNYPKCKYARP------KTLGIKCPECG--IGELTARKSKK 683 Query: 825 NKTMVRFSRKTKQQYVSSEK 844 +T +R + +Y++++K Sbjct: 684 GRTFYSCNRYPECKYITNDK 703 >UniRef50_D1Y390 DNA topoisomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y390_9BACT Length = 767 Score = 636 bits (1641), Expect = 0.0, Method: Composition-based stats. Identities = 282/760 (37%), Positives = 395/760 (51%), Gaps = 95/760 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 GK LV+VESP KAKT+ K LGS YVVK+SVGHI DLP Sbjct: 71 GKTLVVVESPTKAKTLTKILGSGYVVKASVGHIVDLP----------------------- 107 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +R+ +D ++++ Y ++ GK V EL+ A A I LA D DREGEAIAW Sbjct: 108 ------KSRLAIDIENDFKPEYILVKGKAPVKKELQAAAATAQKILLAADPDREGEAIAW 161 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ E++G D RV F+EIT +A+R A +P +++DRV+AQQARR +DR+VGY +SP Sbjct: 162 HVAELLGVDPKENCRVRFHEITADAVRNAVKEPAPIDMDRVDAQQARRVLDRLVGYTLSP 221 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLWKKI RGLSAGRVQSVA+ ++ ERE+EI+ FVP+++W V T G A L V + Sbjct: 222 LLWKKIRRGLSAGRVQSVALAILCEREQEIENFVPQDYWNVFVDATADDGRAYRLHVERE 281 Query: 242 N-------DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 N K + + L++ V K K APF TST+QQ A+ Sbjct: 282 NGRSLLSDGKTLAIDTLAKVRDIEKTLKEKPLIVASFTAKKNARKQPAPFKTSTMQQIAA 341 Query: 295 TRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 +RLGF ++TM +AQ L+E G +TYMRTDS ++ +A++ R I +GK Sbjct: 342 SRLGFSPRRTMGIAQSLFEGVAIPGHGTVGLVTYMRTDSLRMAPEALSQARKVIEGRWGK 401 Query: 346 KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMT 404 KYLP Y + N+Q+AHEAIRP+D + ES+++ + A+ +LY +IWR+ VA QM Sbjct: 402 KYLPAKAVVYQAGANAQDAHEAIRPTDFALTPESIRESLTAEQYRLYDMIWRRSVASQMA 461 Query: 405 PAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVEL 464 PA DS TL G + L+A+G + FDGW V K D ++ +G+ L + + Sbjct: 462 PAVVDSATLDCECGKYGLRAQGASVGFDGWGAVWDLDVK---DAMIQKAREGELLNIRNV 518 Query: 465 TPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMG 523 + TKPPARF+E++L+K LE GIGRPSTYA+I+ T+ DR YV E R+ ++G Sbjct: 519 QSEKEQTKPPARFTESTLIKTLEDDGIGRPSTYATIVETLYDRSYVAREEGRKLKPSELG 578 Query: 524 EIVTDRLEENF-----RELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 V L E+F +++ FT+ ME+SLDQV + + W ++ F+ FT + +A Sbjct: 579 RSVNKFLLEHFDGKSTSPIVDVGFTSSMESSLDQVESGKKNWVELIGQFWKPFTDAIAEA 638 Query: 579 EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVP 638 EK P + P LT CP CGR + + G F+GCSG+ C + Sbjct: 639 EKAP---VVPPPPPELTGETCPQCGRPLVKKQGRFGDFIGCSGFP-----ECHYIKPVQK 690 Query: 639 ENEVLNVLEGEDAETNALRAKRRCPKCGTA----MDSYLIDPKRKLHVCGNNPTCDGYEI 694 E V CPKCG + R + C P CD Sbjct: 691 EIGV------------------PCPKCGNEHGGQVVQRKSKKGRTFYGCSRYPDCDYVSW 732 Query: 695 EEGEFRIKGYDGPIVECEKCGSEMH-LKMGRFGKYMACTN 733 + +C CG M + R C + Sbjct: 733 NKPAPE---------KCPLCGGLMEYVGRSRTPVCTKCAH 763 Score = 77.5 bits (189), Expect = 2e-12, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 40/132 (30%), Gaps = 19/132 (14%) Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 C +CG + K GRFG ++ C+ EC + + + V PK + Sbjct: 652 TGETCPQCGRPLVKKQGRFGDFIGCSGFPECHYIKPVQKEIGVPCPKCG---------NE 702 Query: 766 SDAYFVLRDGAAGV-FLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEG 824 V R G F + +P V ++ P + + Sbjct: 703 HGGQVVQRKSKKGRTFYGCSRYPDCDY-----VSWNKPAPEKCPLCGGLMEYVGRSR--- 754 Query: 825 NKTMVRFSRKTK 836 + + K K Sbjct: 755 TPVCTKCAHKGK 766 Score = 64.4 bits (155), Expect = 2e-08, Method: Composition-based stats. Identities = 20/118 (16%), Positives = 38/118 (32%), Gaps = 19/118 (16%) Query: 726 GKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANT 785 G++ T I + P L C + V + G G F+ + Sbjct: 625 GQFWK------PFTDAIAEAEKAPVVPPPPPELTGETCPQCGRPLVKKQGRFGDFIGCSG 678 Query: 786 FPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 FP+ + P+ +E+ + + G + + R S+K + Y S Sbjct: 679 FPECHYIK-PVQKEIG------------VPCPKCGNEHGGQVVQRKSKKGRTFYGCSR 723 >UniRef50_D1B572 DNA topoisomerase n=7 Tax=Campylobacterales RepID=D1B572_SULD5 Length = 694 Score = 635 bits (1638), Expect = e-180, Method: Composition-based stats. Identities = 285/748 (38%), Positives = 397/748 (53%), Gaps = 71/748 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+IVESP KAKTI +LG +Y V +S GHIRDLP S K Sbjct: 6 KNLIIVESPTKAKTIKNFLGKNYTVVASKGHIRDLPKSSFGIKIDN-------------- 51 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + Y V VV E+K+LA++AD +Y+ATD DREGEAI +H Sbjct: 52 --------------QTFIPEYRVPKDHASVVKEIKELAKEADQVYIATDEDREGEAIGFH 97 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 + IG D R+VF+EITKNAI A P L+ +NAQQARR +DR+VGY +SPL Sbjct: 98 IATAIGKDPKSLPRIVFHEITKNAITHALENPRILDESSINAQQARRLLDRIVGYKLSPL 157 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 L KI +GLSAGRVQS +++VV+RE+EI+AF EEFW +DA EA ++ + Sbjct: 158 LSSKIQKGLSAGRVQSSTLKIVVDREKEIRAFKEEEFWSIDALFNKT-IEASLVEFEGEK 216 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 + N+E+ A L K + V E K S P F+TSTLQQ+AS+ LG+ K Sbjct: 217 IEKMSIGNQERAYAIKEKLLKEAFHVALLEKKERESSPSPAFMTSTLQQSASSALGYSPK 276 Query: 303 KTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 KTMM+AQ LYE G ITYMRTDS N+S++A+ R I +GK YLPE Sbjct: 277 KTMMLAQTLYEGVKTHQGVQGVITYMRTDSLNVSKEAIEAAREQILSQYGKTYLPEKARF 336 Query: 355 YASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 YA+K + +QEAHEAIRP+ + + D KLY LI+ +F+A QM A+++S T Sbjct: 337 YANKSKGAQEAHEAIRPTILEFTPAIASAYLAPDELKLYALIYNRFLASQMNNARFESQT 396 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 L + + KA GR L FDG+ KV D+D++LP + +TL +L QHFT+ Sbjct: 397 LIFESQSGKFKASGRKLLFDGFYKVYG---DNDKDKLLPDLALKQEVTLSKLDANQHFTE 453 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PP+R+SEASL+K+LE GIGRPSTYA IS + R Y+ +E ++ ++ VT+ LE+ Sbjct: 454 PPSRYSEASLIKKLESLGIGRPSTYAPTISVLSARDYINIEKKQIVPTEVAFQVTELLEQ 513 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 +F ++++ FT+ ME LD +A + +W+A+L +F+ F Q+ K + + Sbjct: 514 HFPQIVDSSFTSTMEERLDLIAEDKEDWQAILWNFYEPFDAQVAK----GKTEIQSQKVI 569 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 V T CP CG+++ R G F+ CS Y CK T NL +E + + Sbjct: 570 VFTGEMCPECGKELVRRKGRFGEFIACSTYPT-----CKYTQNLKKVSESAPKEKVTLSV 624 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 CP+CG + + CGN P C E +C Sbjct: 625 P--------CPECGGEIIERSSRRGK-FFGCGNYPKCKFISNYE---------PTDKKCP 666 Query: 713 KCGSEMHLKMGRFGKYMACTNEECKNTR 740 +CG M + R + C +CK+ Sbjct: 667 ECGYIMAKRELRKKEIYECI--KCKHKE 692 Score = 90.9 bits (224), Expect = 2e-16, Method: Composition-based stats. Identities = 27/130 (20%), Positives = 51/130 (39%), Gaps = 9/130 (6%) Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 C +CG E+ + GRFG+++AC+ CK T+ + + E AP ++ +PC + Sbjct: 572 TGEMCPECGKELVRRKGRFGEFIACSTYPTCKYTQNLKKVSESAPKEK---VTLSVPCPE 628 Query: 766 SDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGN 825 + R G F +PK + + PE +A + E Sbjct: 629 CGGEIIERSSRRGKFFGCGNYPKCKFISNYEPTDKK-----CPECGYIMAKRELRKKEIY 683 Query: 826 KTMVRFSRKT 835 + + ++ Sbjct: 684 ECIKCKHKEE 693 Score = 65.1 bits (157), Expect = 1e-08, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 36/92 (39%), Gaps = 7/92 (7%) Query: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFR 804 G+ + + C + V R G G F+A +T+P + T+ L + Sbjct: 558 KGKTEIQSQKVIVFTGEMCPECGKELVRRKGRFGEFIACSTYPTCKYTQN-----LKKVS 612 Query: 805 DRLPEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 + P K + P + G + + R SR+ K Sbjct: 613 ESAP-KEKVTLSVPCPEC-GGEIIERSSRRGK 642 >UniRef50_A8RBU5 DNA topoisomerase n=9 Tax=Bacteria RepID=A8RBU5_9FIRM Length = 718 Score = 630 bits (1625), Expect = e-179, Method: Composition-based stats. Identities = 286/779 (36%), Positives = 412/779 (52%), Gaps = 81/779 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESP+K+KTI KYLG+DY+V SS GHIRDL T+G Sbjct: 2 KNLVIVESPSKSKTIEKYLGNDYMVVSSKGHIRDLATTGKGG------------------ 43 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +G+D H++E Y++ K VV ELK LA+K+DHIYLA+D DREGEAIAWH Sbjct: 44 --------LGIDVEHDFEPTYKISADKRSVVKELKDLAKKSDHIYLASDPDREGEAIAWH 95 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L +V+G D +R+VFNEITK A+ +A P ++I V +Q+ RR +DR++G+ +S L Sbjct: 96 LAQVLGLDVNDENRIVFNEITKGAVTEALKHPRTIDIPMVKSQETRRMLDRIIGFKLSKL 155 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 L KI SAGRVQSVA+RL+VERE+EI+AF EE+W + A S + + Sbjct: 156 LQSKIKSK-SAGRVQSVALRLIVEREQEIRAFKSEEYWTLAALVDKDSKK-FNANLIRIG 213 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K +++ A +S + V E K +P PFITSTLQQ AST+LGFG K Sbjct: 214 GKKAELKTQQEVDAIISRC--HEFKVSSIEKKVRKKEPRMPFITSTLQQEASTKLGFGAK 271 Query: 303 KTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 KTM +AQ+LYE G I+YMRTDST LS+ V YI D +GK Y + Sbjct: 272 KTMQIAQKLYEGIALQGGNAEGLISYMRTDSTRLSEQFVRDAEQYIEDTYGKAYCGRARQ 331 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 + EN+Q+AHEAIRP+++ ES+K+ + D KLY+LI+ + +A M P+K + Sbjct: 332 --KNSENAQDAHEAIRPTNIQHTPESIKNYLTNDQYKLYKLIYARTLASLMAPSKSNVVN 389 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 + + D A G IL FDG+ K+ ++ +LP + +G+ L V L QHFT+ Sbjct: 390 AIIVSEDCEFSANGSILAFDGYLKIYHDYETVKDE-MLPVLEEGEKLEKVRLEGKQHFTE 448 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN-------RRFYAEKMGEI 525 PP R+SEA L+K+LE++GIGRPSTYA II T+Q RGYV +E + F+ + GE+ Sbjct: 449 PPLRYSEARLIKDLEEKGIGRPSTYAIIIDTLQARGYVSLEKSSEGSKTKVFFPSEQGEL 508 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 +L+E F L+N +TA+ME LD++A + + L F++ F L+ A + E+ Sbjct: 509 TDAKLKEFFSNLINVTYTAEMEAKLDEIAANTLDNIEELKRFYAKFEPLLENAYEHMEKK 568 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 + T CP CG ++ R G F+ C + C+ T Sbjct: 569 ELE-----RTGELCPECGSELVYRVGRYGKFISCINFPS-----CRYT------------ 606 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYD 705 + E + CP CG+ M C N PTC + + + Sbjct: 607 ---KSEEEEENASDEVCPHCGSKMVMKK-GRYGSFLACSNYPTCKYIKNNKPKEEPVP-- 660 Query: 706 GPIVECEKCGSEMHLKMGRFG-KYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 C +CG + + RFG ++ C+N +C+ +K + + ++ V Sbjct: 661 -TGENCPECGHPLVKRKSRFGTTFVGCSNYPKCRYIKKEPKKAKEKKSDKEAVGEKNEE 718 Score = 94.8 bits (234), Expect = 1e-17, Method: Composition-based stats. Identities = 30/149 (20%), Positives = 55/149 (36%), Gaps = 23/149 (15%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKED 754 K + C +CGSE+ ++GR+GK+++C N C+ T+ Sbjct: 562 YEHMEKKELERTGELCPECGSELVYRVGRYGKFISCINFPSCRYTKSEEEEEN------- 614 Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYL 814 + C + V++ G G FLA + +P + + +E E + Sbjct: 615 ---ASDEVCPHCGSKMVMKKGRYGSFLACSNYPTCKYIKNNKPKE---------EPVPTG 662 Query: 815 ADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 + P+ G+ + R SR S Sbjct: 663 ENCPE---CGHPLVKRKSRFGTTFVGCSN 688 Score = 56.7 bits (135), Expect = 4e-06, Method: Composition-based stats. Identities = 16/99 (16%), Positives = 29/99 (29%), Gaps = 15/99 (15%) Query: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFR 804 ++ + C + + V R G G F++ FP R T++ EE Sbjct: 559 ENAYEHMEKKELERTGELCPECGSELVYRVGRYGKFISCINFPSCRYTKSEEEEENASDE 618 Query: 805 DRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 G+K +++ R S Sbjct: 619 V--------------CPHCGSKMVMKKGRYGS-FLACSN 642 >UniRef50_P34185 DNA topoisomerase 1 n=39 Tax=Bacteria RepID=TOP1_SYNE7 Length = 883 Score = 629 bits (1621), Expect = e-178, Method: Composition-based stats. Identities = 273/867 (31%), Positives = 405/867 (46%), Gaps = 90/867 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP KA+TI YL DY V++S+GH+RDLP S A Sbjct: 1 MPK-LVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQS---------------ASDIP 44 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + +G + +GVD +N+ Y V K+K+V LK + AD + LATD DREGE+I+ Sbjct: 45 TELKGEKWSNLGVDVENNFAPLYIVPKDKKKIVKTLKDALKDADELILATDEDREGESIS 104 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ R+VF+EIT+ AI+ A +++ V+AQ+ RR +DR+VGY +S Sbjct: 105 WHLLQLLQPR-VPTKRMVFHEITQEAIQAALKNCRDVDQRLVHAQETRRILDRLVGYTLS 163 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWKKIA GLSAGRVQSVAVRL+V+RER +AF +W++ A T +G+ A T Sbjct: 164 PLLWKKIAWGLSAGRVQSVAVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEAKLWTL 223 Query: 241 ------------------QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 + +++++ +A L+ + V E+KPTT KP Sbjct: 224 AGQRLATGNDFDESTGQIIAGRQVCLLDQQEAEALRDRLQTQPWQVKSLEEKPTTRKPAP 283 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDN 342 PF TSTLQQ ++ +L ++TM +AQ LYE G+ITYMRTDS +LSQ A+ R + Sbjct: 284 PFTTSTLQQESNRKLRLSARETMRVAQSLYERGFITYMRTDSVHLSQQAIEAARSCVEQM 343 Query: 343 FGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 +GK YL P Q+ +K +N+QEAHEAIRP+ + LY LIW++ +A Sbjct: 344 YGKNYLSPQPRQFTTKSKNAQEAHEAIRPAGNTFRLPQETGLSGAEFALYDLIWKRTIAS 403 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------PALRKGDEDRILPAVNK 455 QM A+ ++ + + +A G+ + F G+ + P D + +LPA+ Sbjct: 404 QMAEARQTMLSVLLEVDNAEFRASGKRIDFPGFFRAYVEGSDDPDAALEDREILLPALKV 463 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 GD T EL H T+PPAR++EASLVK LE GIGRPSTYASII TI DRGY ++ + Sbjct: 464 GDRPTCQELAAIGHETQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVSN 523 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 VT LE++F +L++ F+A+ME SLD ++N E +W L F+ Sbjct: 524 TLTPTFTAFAVTALLEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYLSQFYRGDRGLE 583 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL--GCSGYALPPKERCKTT 633 ++ + E + V G +R G +L G + + T Sbjct: 584 EQVKLRESEIDPAAARTVALE------GLPAKVRIGRFGAYLEAEADGEPIKANLPKELT 637 Query: 634 INLVPENEVLNVLEGEDAETNA------------LRAKRRCPKCGTAMDSYLI-DPKRKL 680 + V +L + + L P + PKR Sbjct: 638 PADLDVQRVETLLRQKTEGPDQLGTHPETDEPIYLLTGAYGPYVQLGAATEEKPKPKRAS 697 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTR 740 G + E + + E + G + +GRFG Y+ C + Sbjct: 698 LPKGMSLETISL---EQAVGLLSLPRTLGEHPETGRRIQAGLGRFGPYVVCDLGGGEKDY 754 Query: 741 KILR------------------NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLA 782 + L+ + + + A + +G G++L Sbjct: 755 RSLKADDDVLTIDLDRALELLAQPKKSRGRGKEPIREVGLHPDDQAPIQIFEGPYGLYL- 813 Query: 783 ANTFPKSRETRAPLVEELYRFRDRLPE 809 K + A L E+ L Sbjct: 814 -----KHGKVNASLPEDEKPETISLET 835 >UniRef50_Q256J1 DNA topoisomerase I-fused to SWI domain n=18 Tax=Chlamydiales RepID=Q256J1_CHLFF Length = 862 Score = 628 bits (1620), Expect = e-178, Method: Composition-based stats. Identities = 280/793 (35%), Positives = 405/793 (51%), Gaps = 84/793 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K+L++VESPAK KT+ K LG ++ SS+GH+ DLP Sbjct: 1 MKKSLIVVESPAKIKTLQKLLGKGFIFASSLGHVVDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 G+D H++E Y++LP K++V++++ +LA D +YL+ D DREGEAIA Sbjct: 39 -------AKTFGIDIEHDFEPDYQILPDKQEVINQICKLASSCDVVYLSPDPDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ + + + RV FN ITK A+ +A P E+++ VNAQQARR +DR+VGY +S Sbjct: 92 WHIANQL-PKNTQIQRVSFNAITKGAVNEALKHPREIDMALVNAQQARRLLDRIVGYKIS 150 Query: 181 PLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-EALALQ 237 P+L +K+ + G+SAGRVQSVA++LVV+RE+ I+AFVP E+W + P + Sbjct: 151 PILSRKLQQRSGISAGRVQSVALKLVVDREKAIEAFVPTEYWNIRVFLQDPKTSKTFWAH 210 Query: 238 VTHQNDKPFR--------------PVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 + + K + ++ + Q LLE A Y V E K P Sbjct: 211 LYSADGKKWEKELPKGKTEDEILLINSEAKAQHYAELLEDASYRVTRVEAKEKRRNAAPP 270 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNM 334 FITSTLQQ AS F KTM +AQ LYE G ITYMRTDS + +A+N Sbjct: 271 FITSTLQQEASRHFRFSSSKTMSVAQTLYEGVELDNEDATGLITYMRTDSVRIDPEALNN 330 Query: 335 VRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQL 393 VR YI D FG++YLP++PN Y SK+ +Q+AHEAIRP+D+++ + L + D LY L Sbjct: 331 VRDYIQDTFGQEYLPKTPNLYTSKKMTQDAHEAIRPTDIHLSPDKLQGKLTNDQHMLYSL 390 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAG-DFRLKARGRILRFDGWTKVM----PALRKGDEDR 448 IW++FVA QM PA YD+ +T+ L+A G +L+F G+ V +E+ Sbjct: 391 IWKRFVASQMNPAIYDTLAMTISTNVKIDLRASGSLLKFKGFLAVYEEKIDDDVAEEENP 450 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508 LP ++ D L +++ Q FTKP RF+EASLVKELEK GIGRPSTYA+I++ IQ R Sbjct: 451 SLPQLHAQDILDKEKVSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSRE 510 Query: 509 YVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 Y EN+R ++G+I++ LE NF +M+ FTA ME+ L+ +A+++ WK +L F+ Sbjct: 511 YTIKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNKKSWKLLLKEFW 570 Query: 569 SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIR-TASTGVFLGCSGYALPPK 627 F + AEK V+T IDC C + ++ A F GCS Y Sbjct: 571 DQFLPVVTTAEK------EAVIPRVVTDIDCSACHKGKLVKIWAKNRYFYGCSEYP---- 620 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNP 687 C E L + + A CP CG M C N P Sbjct: 621 -ECDF----KTSEEELAFNKDDYAVETP--WDSPCPVCGGEMKVRH-GRFGTFLGCLNYP 672 Query: 688 TCDGYEI-EEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILR 744 C G + ++ + C ++ K R+ K + +C+ +C + Sbjct: 673 KCRGTISLHKKGEEVETEEPIPCPAIGCSGKIFKKRSRYNKTFYSCSEYPDCSVIGNTID 732 Query: 745 NGEVAPPKEDPVP 757 P Sbjct: 733 AVITKYTGTQKTP 745 >UniRef50_Q1RIM1 DNA topoisomerase 1 n=35 Tax=Rickettsiales RepID=TOP1_RICBR Length = 800 Score = 627 bits (1616), Expect = e-178, Method: Composition-based stats. Identities = 287/770 (37%), Positives = 411/770 (53%), Gaps = 75/770 (9%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LVIVESPAKAKTINKYLG ++ V +S GHIRDLP+ Sbjct: 2 KLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKG--------------------- 40 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 V P N+ Y++ K V + + A+KA+ +YLATD DREGE+I+WH+ Sbjct: 41 --------SVIPDENFSMKYDISEKAGKYVDAIIKDAKKAESVYLATDPDREGESISWHI 92 Query: 124 REVIGGDDAR-----YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 EVI + + RV FNEITK AI A P +L+ + VNAQQARR +D +VG+ Sbjct: 93 AEVIKEKNKVKSDDFFKRVAFNEITKKAITHAIENPRKLDNNLVNAQQARRALDYLVGFT 152 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +SPLLW+K+ SAGRVQSVA+RL+ ERE EI+ F EE+W++ + E ++ Sbjct: 153 LSPLLWRKLPGCKSAGRVQSVALRLICEREDEIERFKSEEYWDISLKMLNSNNELFTAKL 212 Query: 239 THQND---KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAST 295 TH ND + F N ++ + L+ + V + E K +P PFITS+LQQ A+ Sbjct: 213 THINDQKLEKFSITNDKEAKDLTEKLKSQNFHVDKIEKKQQKRQPQPPFITSSLQQEAAR 272 Query: 296 RLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 +LGF KKTM +AQ+LYE G ITYMRTD LS DAV+ +R I+ ++G KY Sbjct: 273 KLGFSAKKTMQIAQKLYEGVDIGKETIGLITYMRTDGVTLSNDAVDEIRKLINKDYGDKY 332 Query: 348 LPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTP 405 LP SP Y SK +N+QEAHEAIRP+++N + LK +E D KLY+LIW++ +ACQM Sbjct: 333 LPSSPRIYKSKVKNAQEAHEAIRPTNINYIPNDLKEKLEKDYYKLYELIWKRTIACQMEN 392 Query: 406 AKYDSTTLTVGAGDFRL--KARGRILRFDGWTKVMPA---LRKGDEDRILPAVNKGDALT 460 D T+ + + +A G + FDG+ KV +E+++LP + + + L Sbjct: 393 VIMDLVNATLASENKEYLARANGSTIAFDGFYKVYRESIDDEAEEENKMLPPLKEQEHLK 452 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 E+ P QHFT+PP R+SEASLVK+LE+ GIGRPSTYA+I+S +QDR YV +E +RF E Sbjct: 453 TKEIIPNQHFTEPPPRYSEASLVKKLEELGIGRPSTYATILSVLQDRKYVTLEKKRFIPE 512 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK 580 ++G +VT L F++ + YDFTA +EN LD++A + EWK+ L +F++ F ++ K Sbjct: 513 ELGRLVTVFLVGFFKKYVEYDFTAGLENELDEIAAGKLEWKSALGNFWNGFNHNIESVNK 572 Query: 581 DPEEG---------GMRPNQMVLTSIDCPTCG-RKMGIRTASTGVFLGCSGYALPPKERC 630 S CP+C ++ ++ G FL CS Y + Sbjct: 573 QNITEIISYVQQALDYHIFGENKDSKVCPSCKTGELSLKLGKFGAFLACSNYPECNFRKS 632 Query: 631 KTTINLVPE---------NEVLNVLEGEDAETNALRAKRRCPKC-GTAMDSYLIDPKRKL 680 + N E NE + + ++ L+ P I PKR Sbjct: 633 IVSGNDNNEADGEAKDIVNENKVLGKDKEGIEIYLKKGPYGPYIQYGEQVDSKIKPKRSP 692 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 G N + ++ I ++ G E+ + G+FG Y+ Sbjct: 693 LPAGLN---QNDITLDMALKLLSLPLKIGNHKESGEEVLVGYGKFGPYIK 739 Score = 64.4 bits (155), Expect = 2e-08, Method: Composition-based stats. Identities = 32/146 (21%), Positives = 53/146 (36%), Gaps = 11/146 (7%) Query: 701 IKGYDGPIVECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRK----ILRNGEVAPPKED 754 I G + C C E+ LK+G+FG ++AC+N EC + N K+ Sbjct: 590 IFGENKDSKVCPSCKTGELSLKLGKFGAFLACSNYPECNFRKSIVSGNDNNEADGEAKDI 649 Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVF--LAANTFPKSRETRAPLVEELYRFRDRLPEKLR 812 L +K L+ G G + K + R+PL L + L L+ Sbjct: 650 VNENKVLGKDKEGIEIYLKKGPYGPYIQYGEQVDSKIKPKRSPLPAGLNQNDITLDMALK 709 Query: 813 YLA---DAPQQDPEGNKTMVRFSRKT 835 L+ G + +V + + Sbjct: 710 LLSLPLKIGNHKESGEEVLVGYGKFG 735 >UniRef50_A8SJ74 DNA topoisomerase n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SJ74_9FIRM Length = 703 Score = 626 bits (1614), Expect = e-177, Method: Composition-based stats. Identities = 270/760 (35%), Positives = 409/760 (53%), Gaps = 78/760 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESP KAKT++K LGS+Y V +SVGHIRDLP Sbjct: 9 KNLVIVESPTKAKTVSKMLGSNYKVVASVGHIRDLP------------------------ 44 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 ++MG+D +N+E Y + GK + ELK+L + +++IYLATD DREGEAI+WH Sbjct: 45 -----KSKMGIDIENNFEPEYINVRGKASKIKELKELYKNSENIYLATDPDREGEAISWH 99 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 + ++G D +R+ F+EITK +I+++ +++++ VN+QQARR +DR+VGY +SP+ Sbjct: 100 IAYLLGLDINDNNRIEFHEITKKSIKESIKNSRKIDMNLVNSQQARRVLDRLVGYKLSPI 159 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LWKKI GLSAGRVQS ++++ ER+ EI FVPEEFW+++ + E +L Sbjct: 160 LWKKIKSGLSAGRVQSATLKIICERQEEIDNFVPEEFWKIEGIHNVQNIEFKSLYYGEYE 219 Query: 243 DK---PFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 +K N+++ V +K + V + + KP PF TSTLQQ A +LGF Sbjct: 220 NKKIVKKEIKNEKEALKVVEKTDKDNFIVEDVKKVKKERKPQPPFTTSTLQQEAGRKLGF 279 Query: 300 GVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 TM +AQ+LYE G I+YMRTDST +S + V YI++N+GK Y + Sbjct: 280 SSSMTMSIAQQLYEGINVGKEGSVGLISYMRTDSTRISSEIVAEAIEYITENYGKNYASK 339 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYD 409 K+NSQ+AHE +RPS + E +K + ++ KLY+LIW + VA QM Y+ Sbjct: 340 GNEYNLKKKNSQDAHEGVRPSSIFRSPEKIKSYLTSNQYKLYKLIWERTVASQMKAESYE 399 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 ST + + + + K GR FDG++K+ + DE LP + D + ++ +QH Sbjct: 400 STQIVLNSNNCIYKLNGRYTLFDGFSKIYTSSDIKDE--PLPKLEVKDVINAEKIEKSQH 457 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FTKP A F+EASLVK+LE+ GIGRPSTYASII+++ R Y+ +EN++ +G+ V Sbjct: 458 FTKPVANFTEASLVKKLEENGIGRPSTYASIINSLTSRFYILIENKKIIPTDLGKNVNKF 517 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 L NF ++N FT +ME LD++A ++ +WK V+ F++ F L ++E D E+ ++ Sbjct: 518 LVSNFETIINEKFTMEMEEKLDEIAENKKDWKKVISDFYAVFETFLKRSEGDSEDYKIK- 576 Query: 590 NQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE 649 + CP CG+ + I+ G F+GCSG+ C Sbjct: 577 --DEVLDEKCPQCGKNLVIKKTKFGRFIGCSGFP-----DCNY----------------- 612 Query: 650 DAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV 709 + +CPKCG + + ++ + C N P CD ++ Sbjct: 613 -IKKEVKDTGVKCPKCGGRIIEKISKKRKVFYGCENYPECDYAIWDKPIA--------DK 663 Query: 710 ECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVA 749 +CEKCG + RF + C++E C + + Sbjct: 664 KCEKCGKFLVEVKNRFKHALKCSDENCDFEIDLKKKKNEK 703 Score = 71.7 bits (174), Expect = 1e-10, Method: Composition-based stats. Identities = 16/133 (12%), Positives = 43/133 (32%), Gaps = 19/133 (14%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKED 754 + E + +C +CG + +K +FG+++ C+ +C +K +++ Sbjct: 569 DSEDYKIKDEVLDEKCPQCGKNLVIKKTKFGRFIGCSGFPDCNYIKKEVKD--------- 619 Query: 755 PVPLPELPCEKSDAYFVLRDGAAGV-FLAANTFPKSRETRAPLVEELYRFRDRLPEKLRY 813 + C K + + F +P+ + + ++ Sbjct: 620 ----TGVKCPKCGGRIIEKISKKRKVFYGCENYPECDYAIWDKPIADKK----CEKCGKF 671 Query: 814 LADAPQQDPEGNK 826 L + + K Sbjct: 672 LVEVKNRFKHALK 684 Score = 58.2 bits (139), Expect = 1e-06, Method: Composition-based stats. Identities = 14/120 (11%), Positives = 37/120 (30%), Gaps = 17/120 (14%) Query: 724 RFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAA 783 + ++ + R+ + + + + C + V++ G F+ Sbjct: 545 KKDWKKVISDFYAVFETFLKRSEGDSEDYKIKDEVLDEKCPQCGKNLVIKKTKFGRFIGC 604 Query: 784 NTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 + FP + +E+ + P+ G + + + S+K K Y Sbjct: 605 SGFPDCNYIK----KEVKDTGVKCPK-------------CGGRIIEKISKKRKVFYGCEN 647 >UniRef50_Q28MI5 DNA topoisomerase n=13 Tax=Rhodobacterales RepID=Q28MI5_JANSC Length = 907 Score = 625 bits (1612), Expect = e-177, Method: Composition-based stats. Identities = 286/916 (31%), Positives = 415/916 (45%), Gaps = 144/916 (15%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M +V+VESPAKAKTINKYLGSDY V +S GH+RDLP+ Sbjct: 1 MP--VVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPSKDG------------------ 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VDP + +E+ +K V + + + + LATD DREGEAI+ Sbjct: 41 -----------SVDPEEGFFMKWEIGSDSKKHVKAIVDALKDDNSLILATDPDREGEAIS 89 Query: 121 WHLREVIGGDDA-----RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 WHL+E + A SRV FN ITK+A+ +A +P +++++ V A ARR +D +V Sbjct: 90 WHLQEALTSRKAIKTDTPVSRVTFNAITKDAVTKAMAEPRQVDMELVEAYLARRALDYLV 149 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALA 235 G+ +SP+LW+K+ SAGRVQSV +RLVVERE EI+AF P E+W V A TP G+ + Sbjct: 150 GFNLSPVLWRKLPGAKSAGRVQSVCLRLVVEREMEIEAFRPREYWSVRAVLETPRGQTIE 209 Query: 236 LQVTHQNDKPF---RPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 ++T K + + AV + + SV + E KP P PF+TSTLQQ Sbjct: 210 ARLTVLGGKKLDRYDLPSAAEAGLAVQAVSSRKLSVSDVEAKPANRNPSPPFMTSTLQQE 269 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 AS +LG G K+ M AQRLYEAG+ITYMRTD +++ +AV RG I +G Y+P P Sbjct: 270 ASRKLGMGAKQAMSTAQRLYEAGHITYMRTDGIDMAPEAVEDARGAIKTRYGVDYVPGKP 329 Query: 353 NQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 Y +K +N+QEAHE +RP+D++ A LK E D +KLY LIW++ +A QM A+ + T Sbjct: 330 RIYKNKAKNAQEAHECVRPTDMSKAANDLKLSEDDQRKLYDLIWKRTIASQMEAARLERT 389 Query: 412 TLTVGAGD--FRLKARGRILRFDGWTKVMPALR----KGDEDRILPAVNKGDALTLV--- 462 T+T+ + D L+A G+++ FDG+ KV R ++ + LP V+ GD L Sbjct: 390 TVTIASDDREVELRATGQVMLFDGFLKVYEEGRDDAGDDEDSKRLPQVSAGDPLKPSADA 449 Query: 463 ----------------------------------ELTPAQHFTKPPARFSEASLVKELEK 488 + QH T PP R++EA+LVK +E+ Sbjct: 450 MADDYAKYSGDDVVEDDGNGDVRRSKSAILSREGAVLGQQHHTAPPPRYTEATLVKRMEE 509 Query: 489 RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN 548 GIGRPSTYASI+ TIQ+RGYV + R E G +VT L F + YDFTA +E Sbjct: 510 LGIGRPSTYASIMDTIQNRGYVIKDKGRLIPEDKGRLVTVFLSNYFNRYVQYDFTADLEQ 569 Query: 549 SLDQVANHEAEWKAVLDHFFSDFTQQL------------DKAEKDPEEGGMRPNQMVLTS 596 LD+V+ + +K VLD F+ DF + DK + E Sbjct: 570 QLDEVSAGDRHYKDVLDRFWRDFRAAIDETSDLRIGEVLDKINEVLEPHLFPDPGDGTDP 629 Query: 597 IDCPTCG-RKMGIRTAS-TGVFLGCSGYALPPKERCKTTINLVPENEVL---------NV 645 CP CG ++ +RTA G F+GCS Y C+ T P + + Sbjct: 630 RLCPNCGVGRLSMRTARAGGAFIGCSAYP-----ECRYTRPFGPPDPEAEASAIPPDGKL 684 Query: 646 LEGEDAETNALRAKRRCPKCGTA-MDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 L + + + R P M P R+ P E + Sbjct: 685 LGEDQGDEIRIFKGRFGPYVQRGAMTEENKKPPRQSIPKDWTPE---ELDLERALMLLSL 741 Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTNEECK-----------------------NTRK 741 I + G + +GR+G Y+ Sbjct: 742 PRQIGPHPEDGIMVWSNIGRYGPYLKHAESTSDRGGTNANLDGLDEVFTVGMNRAVQLLA 801 Query: 742 ILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELY 801 + + + G G ++ K + A + E + Sbjct: 802 EKVASRGGRGQAAKPLRELGEHPDAGGPVNVMKGKYGPYV------KWDKVNATIPEAID 855 Query: 802 RFRDRLPEKLRYLADA 817 + + ++ + + Sbjct: 856 PEAITMDQAVQLIEER 871 Score = 45.5 bits (106), Expect = 0.009, Method: Composition-based stats. Identities = 27/142 (19%), Positives = 44/142 (30%), Gaps = 9/142 (6%) Query: 702 KGYDGPIVECEKCG-SEMHLKMGRFG-KYMACTN-EECKNTRKILRNGEVAPPKEDPVPL 758 G C CG + ++ R G ++ C+ EC+ TR A P P Sbjct: 623 PGDGTDPRLCPNCGVGRLSMRTARAGGAFIGCSAYPECRYTRPFGPPDPEAEASAIP-PD 681 Query: 759 PELPCEKSDAYFVLRDGAAGVFL--AANTFPKSRETRAPLVEELYRFRDRLPEKLRYLAD 816 +L E + G G ++ A T + R + ++ L L L+ Sbjct: 682 GKLLGEDQGDEIRIFKGRFGPYVQRGAMTEENKKPPRQSIPKDWTPEELDLERALMLLSL 741 Query: 817 APQ---QDPEGNKTMVRFSRKT 835 Q +G R Sbjct: 742 PRQIGPHPEDGIMVWSNIGRYG 763 >UniRef50_P73810 DNA topoisomerase 1 n=13 Tax=cellular organisms RepID=TOP1_SYNY3 Length = 898 Score = 624 bits (1608), Expect = e-177, Method: Composition-based stats. Identities = 266/874 (30%), Positives = 396/874 (45%), Gaps = 91/874 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP KA+TI YL DY V++S+GH+RDLP S + Sbjct: 1 MSK-LVIVESPTKARTIRNYLPQDYRVEASMGHVRDLPASAEEVPAAY------------ 47 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + +GV+ ++ Y + K+KVV EL+ + AD + LATD DREGE+I+ Sbjct: 48 ---KDKSWANLGVNVEDHFSPLYVIPKSKKKVVKELQTALKNADEVILATDEDREGESIS 104 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++ R+VF+EIT+ AIR A +++ + V+AQ+ RR +DR+VGY +S Sbjct: 105 WHLLQLLQP-KVPIKRMVFHEITQEAIRSALENCRDIDENLVHAQETRRILDRLVGYTLS 163 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWKKIA GLSAGRVQSVAVRL+V+RER +AF +W++ A A +T Sbjct: 164 PLLWKKIAWGLSAGRVQSVAVRLIVQRERARRAFKTAGYWDLKAELEQNKNPFQAKLMTL 223 Query: 241 ------------------QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 DK +++ Q A L ++V+ E+KP KP Sbjct: 224 GGTKLANGSDFDPNTGALLPDKQVVVLDEAQAIALKERLTGKPWAVVNTEEKPGVRKPSP 283 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDN 342 PF TSTLQQ A+ +LG + TM +AQ+LYE GYITYMRTDS +LS AV R + Sbjct: 284 PFTTSTLQQEANRKLGISARDTMRVAQKLYEEGYITYMRTDSVHLSDQAVTAARNCVQQM 343 Query: 343 FGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 +GK+YL P QY +K + +QEAHEAIRP+ + ++ LY+LIW++ VAC Sbjct: 344 YGKEYLSPQPKQYTTKSKGAQEAHEAIRPAGTEFRIPNQTGLKDRELALYELIWKRTVAC 403 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------PALRKGDEDRILPAVNK 455 QM A+ ++ + D +A G+ + F G+ + P +++ ILP + Sbjct: 404 QMADARITQLSVLLKVEDAEFRAAGKRIDFPGYFRAYVEGSDDPDAALENQEVILPPLKV 463 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 GD E+ H T+PPAR++EASLVK LE G+GRPSTYASII TI DRGYV++ ++ Sbjct: 464 GDRPNCREIDTVGHETQPPARYTEASLVKTLESEGVGRPSTYASIIGTIIDRGYVQMRSK 523 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 V LE +F +L++ FT++ME LD++A + +W L FF L Sbjct: 524 ALTPTFTAFAVVSLLESHFPDLVDTGFTSRMEQKLDEIAIGKTQWLPYLQGFF------L 577 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 ++ + + + + ++ G ++ + Sbjct: 578 GESGLENQVKVRQDQIDPAIAKAIELENLAAKVKIGKFGPYIEIPQGEEIITASIPQDLT 637 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYL----------------IDPKRK 679 N + + + P+ G + + PKR Sbjct: 638 PADLNPEQVAVLLKQKTEGPDKVGIH-PETGEPIFILIGAYGPYVQLGEATEENKKPKRT 696 Query: 680 LHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNT 739 G P E + + E + G + +GRFG Y+ + Sbjct: 697 SLPKGVKPE---DVTLEMAVGLLALPRNLGEHPESGKNIKASLGRFGPYVVHDQGKDGKD 753 Query: 740 RKILRNGEVAPP-----------------KEDPVPLPELPCEKSDAYFVLRDGAAGVFLA 782 + L+ + + L G GV Sbjct: 754 YRSLKGDDDVLTITLERALELLAEPKRGRGSRTPLKQLGLHPEDQEPVNLFKGPYGV--- 810 Query: 783 ANTFPKSRETRAPLVEELYRFRDRLPEKLRYLAD 816 + K + A L E L + L LA+ Sbjct: 811 ---YIKHGKVNASLPEGETEETITLEKALPLLAE 841 >UniRef50_O83409 DNA topoisomerase 1 n=4 Tax=Treponema RepID=TOP1_TREPA Length = 731 Score = 623 bits (1607), Expect = e-177, Method: Composition-based stats. Identities = 268/763 (35%), Positives = 400/763 (52%), Gaps = 82/763 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESPAKA+TI KYLG+ YVV++S+GH+ DLP Sbjct: 17 KHLVIVESPAKAQTIEKYLGTQYVVRASMGHVIDLP------------------------ 52 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +R+ +D H+++ Y + G+ + + EL+ L++++ ++LA+D DREGEAIA+H Sbjct: 53 -----KSRLAIDIEHDFQPEYITVRGRAQCLKELRTLSKQSLQVFLASDRDREGEAIAYH 107 Query: 123 LREVIGGD-DARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 L + I D R+VFNEIT +AIR A P ++ +VNAQ+ARR +DR+VGY + P Sbjct: 108 LAQSIQAYCDTPIKRIVFNEITPHAIRAAIGHPVPIDTAKVNAQKARRVLDRLVGYHLCP 167 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLW K+ GLSAGRVQSVA+RL+ ERE E+K FVPEE+W V+ + ++ + + Sbjct: 168 LLWHKVKNGLSAGRVQSVALRLICEREVEVKRFVPEEYWTVEGTFEKDK-KSFSALLILI 226 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 K +K++ +A+ L ++ V + +P PF TSTLQQ A+ RLGF Sbjct: 227 QGKKAVFKSKQEATSAIGLFSQSEARVSQIRSFEKNVRPKQPFTTSTLQQCAANRLGFTS 286 Query: 302 KKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 +KTM +AQ+LYE G ITYMRTDS +S+ AV VR +I+ +F LP +PN Sbjct: 287 RKTMQVAQQLYEGVSLGTHRVGLITYMRTDSVRVSEAAVKEVRAWIATHF-SDALPGTPN 345 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 +YA+K SQ+AHEAIRP+ V E +K + D +LY LIW +FVA QMT A+ S T Sbjct: 346 RYAAKGKSQDAHEAIRPTYVAHTPERIKAHLTRDQIRLYTLIWERFVASQMTDARVRSLT 405 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGD-EDRILPAVNKGDALTLVELTPAQHFT 471 + AG A + G+ +V+ L D +LP +G+ + L + QHFT Sbjct: 406 FEITAGPAVFSATETQVIEQGFYRVLKMLSPKDLSKAVLPPTKEGEVVALHNVQSVQHFT 465 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 + P R+++AS+VK LE++GIGRPSTYA IS + DR YV ++ +G++++D L Sbjct: 466 QGPVRYTDASIVKMLEEKGIGRPSTYAPTISVLLDRYYVTRIQKQLMPTPLGKVISDLLT 525 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 F ++++ FTA+ME+ LD+V + +W V+ F+ F++++ KD MR Sbjct: 526 TYFHDVVDVSFTARMESKLDEVEEDKIKWNCVIADFYPAFSEKVSTVMKDL--NSMRGVF 583 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 T + C CG M + G FL C + C+ T + Sbjct: 584 DEKTDVVCSQCGDTMVKKLGRFGFFLACGKFP-----ECRNTQPVP-------------- 624 Query: 652 ETNALRAKRRCPK--CGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV 709 +CP+ C + +++ + C P CD + Sbjct: 625 -------LAKCPRPACDGNIVGKKTRGRKEFYGCTRFPVCDFVTHFK---------PTFA 668 Query: 710 ECEKCGSEMHLKMGRF-GKYMACTNEECKNTRKILRNGEVAPP 751 C +C + K R G Y AC N EC+ +N + Sbjct: 669 VCPQCRCFLVEKSNRRVGTYTACVNPECRYVSPTRKNLSLGKE 711 Score = 62.8 bits (151), Expect = 5e-08, Method: Composition-based stats. Identities = 22/143 (15%), Positives = 34/143 (23%), Gaps = 28/143 (19%) Query: 656 LRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCG 715 + C +CG M L CG P C + + C Sbjct: 585 EKTDVVCSQCGDTMVKKL-GRFGFFLACGKFPECRNTQPVPLAKCPR---------PACD 634 Query: 716 SEMHLKMGR-FGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLR 773 + K R ++ CT C V C + + V + Sbjct: 635 GNIVGKKTRGRKEFYGCTRFPVCDFVTHFKPTFAV--------------CPQCRCFLVEK 680 Query: 774 DGAA-GVFLAANTFPKSRETRAP 795 G + A P+ R Sbjct: 681 SNRRVGTYTACVN-PECRYVSPT 702 Score = 62.4 bits (150), Expect = 8e-08, Method: Composition-based stats. Identities = 24/90 (26%), Positives = 32/90 (35%), Gaps = 16/90 (17%) Query: 704 YDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 + V C +CG M K+GRFG ++AC EC+ PVPL + P Sbjct: 584 DEKTDVVCSQCGDTMVKKLGRFGFFLACGKFPECR--------------NTQPVPLAKCP 629 Query: 763 CEKSDAYFVLRDGA-AGVFLAANTFPKSRE 791 D V + F FP Sbjct: 630 RPACDGNIVGKKTRGRKEFYGCTRFPVCDF 659 Score = 55.1 bits (131), Expect = 1e-05, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 35/92 (38%), Gaps = 18/92 (19%) Query: 752 KEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKL 811 + ++ C + V + G G FLA FP+ R T+ P+ Sbjct: 580 RGVFDEKTDVVCSQCGDTMVKKLGRFGFFLACGKFPECRNTQ-PVP-------------- 624 Query: 812 RYLADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 LA P+ +GN + + +R K+ Y + Sbjct: 625 --LAKCPRPACDGN-IVGKKTRGRKEFYGCTR 653 >UniRef50_Q2J4Z1 DNA topoisomerase n=10 Tax=Bacteria RepID=Q2J4Z1_FRASC Length = 1049 Score = 620 bits (1600), Expect = e-176, Method: Composition-based stats. Identities = 291/915 (31%), Positives = 411/915 (44%), Gaps = 118/915 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LVIVESPAKAKTI YLG + V+SS+GHIRDLP S + + Sbjct: 79 GNRLVIVESPAKAKTIAGYLGPGWQVESSIGHIRDLPRSAADVPAAH------------- 125 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 +G R+GVD +++E Y V P K+ VS+LK L + A +YLATD DREGEAIAW Sbjct: 126 --KGKPWARLGVDVDNDFEPLYIVTPDKKPQVSKLKALVKDASELYLATDEDREGEAIAW 183 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL + + R+VF+EIT AI++A + P +++ + VNAQ+ RR +DR+ GY VSP Sbjct: 184 HLLQTLKP-TVPVKRMVFHEITPQAIQRAVDNPRDIDKNLVNAQETRRILDRLYGYEVSP 242 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST--------------- 226 +LWKK+ LSAGRVQSVA R++VERER F E+W ++ Sbjct: 243 VLWKKVMPRLSAGRVQSVATRILVERERARMRFHSAEYWNIEGLFGATVARQAWSGADGT 302 Query: 227 ---------------TTPSGEALALQVTHQNDKPF-----------------RPVNKEQT 254 L + N +++ Sbjct: 303 PGSGPDGPGAGSIRGDGVEKTPLPATLIALNGNRIATGRDFSPTGQLVSSGVTRLDEATA 362 Query: 255 QAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA 314 ++ L A ++V E KP P PF+TSTLQQ A +L F ++TM +AQRLYE Sbjct: 363 RSLAERLADAAFTVRSVETKPYRRSPYPPFMTSTLQQEAGRKLRFSSQRTMQVAQRLYEN 422 Query: 315 GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDV 373 GYITYMRTDSTNLS+ A+ R + +G +Y+P P YA K +N+QEAHEAIRP+ Sbjct: 423 GYITYMRTDSTNLSKTALTAARAQAASLYGPEYVPARPRTYAKKVKNAQEAHEAIRPAGD 482 Query: 374 NVMA--ESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA-----GDFRLKARG 426 + E +++ D+ +LY+LIW++ VA QM A+ S T+ +GA D A G Sbjct: 483 HFRTPGEVRGELDVDSYRLYELIWQRTVASQMADARGTSATIRLGATSSAGEDAEFSASG 542 Query: 427 RILRFDGWTKVM------PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEA 480 +++ F G+ + P D +R LP V +GD LT LTP H T PPARF+EA Sbjct: 543 KVITFPGFLRAYVEGADDPDAELEDRERRLPDVRQGDPLTTRSLTPRGHTTSPPARFTEA 602 Query: 481 SLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY 540 SLVK LE+ GIGRPSTYASII TIQDRGYV + + V LE++F L++Y Sbjct: 603 SLVKTLEELGIGRPSTYASIIGTIQDRGYVWKKGSALVPSFVAFAVVGLLEDHFTRLVDY 662 Query: 541 DFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR------PNQMVL 594 FTA ME+ LD +A A L F+ D A + ++ Sbjct: 663 RFTATMEDDLDDIAAGTAASTDWLTRFYFGTGDGTDPAADGLKHLVNERLGEIDAREVNS 722 Query: 595 TSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETN 654 + G + +R G ++ + R +L P+ ++ G A + Sbjct: 723 IPLGETDDGTLLVVRVGRYGPYVQ------HGERRASVPDDLAPDELTVDKALGLLAAPS 776 Query: 655 ALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVEC--- 711 R P G + + + + P + D + Sbjct: 777 GDRMLGIDPASGATITAKAGRFGPYVTTDTDPPRTSSLLRGMSLETLTLDDAVRLLTLPR 836 Query: 712 ----EKCGSEMHLKMGRFGKYMA----------------CTNEECKNTRKILRNGEVAPP 751 G E+ + GR+G Y+ T +E + Sbjct: 837 ILGAGDDGEEVTAQNGRYGPYVKKGAESRSLESEDQLFTVTLDEALALLSQPKARGRRQA 896 Query: 752 KEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKL 811 + P S V+R+G G ++ ET A L + Sbjct: 897 AQSPPLRELGTDPASGKPMVVREGRFGPYVTDG------ETNASLRKGDTVETITDERAA 950 Query: 812 RYLADAPQQDPEGNK 826 LAD + P K Sbjct: 951 ELLADRRARGPATAK 965 >UniRef50_Q87AQ6 DNA topoisomerase 1 n=26 Tax=Gammaproteobacteria RepID=TOP1_XYLFT Length = 815 Score = 620 bits (1598), Expect = e-176, Method: Composition-based stats. Identities = 260/768 (33%), Positives = 393/768 (51%), Gaps = 76/768 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKAKTINKYLG D+ V +S GH+RDL Sbjct: 1 MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEG------------------ 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VDP + + Y+++ EK V + + A+ AD IYLATD DREGEAI+ Sbjct: 43 -----------AVDPENGFAMRYDLIDKNEKHVEAITKAAKTADSIYLATDPDREGEAIS 91 Query: 121 WHLREVIGGD----DARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 WH+ E++ D R+VF EIT AI++A KP + D V+AQQARR +D +VG Sbjct: 92 WHISEILKERGLLKDKPMQRIVFTEITPRAIKEAIQKPRMIASDLVDAQQARRALDYLVG 151 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA--L 234 + +SP+LW+K+ RGLSAGRVQS A+R++VERE EI+AF+ E+W + A T P+ Sbjct: 152 FNLSPVLWRKVQRGLSAGRVQSPALRMIVEREEEIEAFITREYWSIHAECTHPAQHFSAK 211 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLLEKA---RYSVLEREDKPTTSKPGAPFITSTLQQ 291 +++ + + F + + AA +++A R + + +K +P PFITSTLQQ Sbjct: 212 LIKLDGKKFEQFTITDSDTAAAAQRRIQQAAQGRLHITDVTNKERKRRPAPPFITSTLQQ 271 Query: 292 AASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 AS +LGF +KTM +AQ+LYE G ITYMRTDS NLS DA++ +R I+ + Sbjct: 272 EASRKLGFTTRKTMQIAQKLYEGIALGEEGSVGLITYMRTDSVNLSLDALSEIRDIIARD 331 Query: 343 FGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVA 400 +G LP+ PN Y +K +N+QEAHEA+RP+ + + + +LY+L+W++ VA Sbjct: 332 YGTNALPDKPNVYTTKSKNAQEAHEAVRPTSALRTPTQVAPYLSNEEHRLYELVWKRTVA 391 Query: 401 CQMTPAKYDSTTLTVGAGDF-RLKARGRILRFDGWTKVMPALR------KGDEDRILPAV 453 QM PA ++T++ + AG+ +A G + G+ V + DE R LP + Sbjct: 392 SQMIPAILNTTSVDLAAGNEHVFRATGTTVVVQGFLAVYEEGKDNKNAEDDDEGRKLPVM 451 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513 G+ + L + QHFT+PP R++EA+LVK LE+ GIGRPSTYASII T+ R YV +E Sbjct: 452 KTGENVPLERILTEQHFTQPPPRYTEAALVKALEEYGIGRPSTYASIIQTLLFRKYVDME 511 Query: 514 NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ 573 R F +G V+ L +F + ++YDFTA +E+ LD ++ E EW ++ F+ F + Sbjct: 512 GRSFRPTDIGRAVSKFLSSHFTQYVDYDFTAHLEDELDAISRGEEEWIPLMKKFWVPFKE 571 Query: 574 QLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG--------CSGYALP 625 ++ + V PT G+++ R G + +A Sbjct: 572 LVED---KKDSLDKTDAGSVRLLGIDPTSGKEVSARIGRFGPMVQIGTVDDEEKPRFASL 628 Query: 626 PKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL--HVC 683 + +I+L E+ + + + + G Sbjct: 629 RPNQSIYSISLEEAIELFKMPRVLGEDQSQQVSV------GIGRFGPFAKRGSTYVSLKS 682 Query: 684 GNNPTCDGYEIEEGEFRIKGYDGPIVECEKC-GSEMHLKMGRFGKYMA 730 ++P K + S++ + GRFG Y++ Sbjct: 683 EDDPYTIDLARATLLINEKEEIARNRIIKDFENSQIQVLNGRFGPYIS 730 >UniRef50_D0LEI6 DNA topoisomerase n=36 Tax=Actinomycetales RepID=D0LEI6_GORB4 Length = 1031 Score = 618 bits (1594), Expect = e-175, Method: Composition-based stats. Identities = 293/938 (31%), Positives = 423/938 (45%), Gaps = 129/938 (13%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 + LVIVESP KA+ I YLGS+YVV+SS GHIRDLP + Sbjct: 16 RRLVIVESPTKARKIAGYLGSNYVVESSRGHIRDLPRGAADVPAKY-------------- 61 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +G R+GV+ N+E Y V P K+ V+ELK L D +YLATD DREGEAIAWH Sbjct: 62 -KGQPWARLGVNVDENFEPLYVVSPDKKSTVTELKSLMRDVDELYLATDGDREGEAIAWH 120 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L E + R+VF+EIT+ AIR A P +L+ID V+AQ+ RR +DR+ GY VSP+ Sbjct: 121 LLETLKP-KIPVKRMVFHEITEPAIRAAAENPRDLDIDLVDAQETRRILDRLYGYEVSPV 179 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS------------ 230 LWKK+ LSAGRVQSVA R++VERERE AFV E+W++DA+ Sbjct: 180 LWKKVMPKLSAGRVQSVATRIIVERERERMAFVSAEYWDIDANMDAGKDASPQTFNARLV 239 Query: 231 ---------GEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 G + + +++ + +A L+ A +V E+KP T +P Sbjct: 240 GVDDARVATGRDFDSRGALKRADGVVVLDETRARALADALDGADITVSSVEEKPYTRRPY 299 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 APF+TSTLQQ A +L F +TM +AQRLYE G+ITYMRTDST LS+ A+N R + Sbjct: 300 APFMTSTLQQEAGRKLRFSSDRTMRIAQRLYENGFITYMRTDSTTLSESAINAARAQARE 359 Query: 342 NFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLYQLIWRQF 398 +G Y+ +P Q+ K +N+QEAHEAIRP+ + +EAD +LY+LIW++ Sbjct: 360 LYGDNYVHPTPRQHTRKVKNAQEAHEAIRPAGESFRTPGQVAGQLEADEFRLYELIWQRT 419 Query: 399 VACQMTPAKYDSTTLTVGAGD-------FRLKARGRILRFDGWTKVMPALRKG------- 444 VA QM AK TTL++ A GR + F G+ Sbjct: 420 VASQMADAKG--TTLSLRMTGTASTGETCVFAASGRTITFPGFLSAYVETVDDLAGGQAD 477 Query: 445 DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTI 504 D + LP + +G AL EL+ H T PPARF+EASLVK LE+ GIGRPSTYASII TI Sbjct: 478 DAENRLPQLREGQALRATELSADGHSTNPPARFTEASLVKVLEELGIGRPSTYASIIGTI 537 Query: 505 QDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 QDRGYV + + V LE F+ L++YDFTA +E+ LD++A+ L Sbjct: 538 QDRGYVVKKGNALVPSWIAFAVVGLLEAYFQGLVDYDFTASLEDDLDEIASGRENRTRWL 597 Query: 565 DHFF------------SDFTQQLDKAEKDPEEGGMRPNQMVLTSID-----CPTCGRKMG 607 F+ ++ K + G+ ++ ++ GR + Sbjct: 598 TEFYFGDAAPNAEHDAEIAGSEIAKHGGLKKLVGVNLEEIDAREVNSIRLFDDEQGRPVY 657 Query: 608 IRTASTGVFLGCSGY--------ALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAK 659 +R G +L + A P +R ++ P+ L + E + R+ Sbjct: 658 VRVGRFGPYLERNLSAASAASPDAEPDLQRANLPADITPDELTLALAEKLFSTPQEGRSL 717 Query: 660 RRCPKCGTAMDSYLIDPKRKL--HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSE 717 P G + + + + ++ DG DG + +E Sbjct: 718 GVDPVTGHEIVAKEGRFGPYVTEILPSDDDDDDGNSPATVPAGPTPRDGGGTGGQGSDAE 777 Query: 718 MHLKMGRFG-------------------KYMACTNEECKNTRKILRNGEVAPPKED---- 754 + G K + + +D Sbjct: 778 VVPLDTPSGGGTATKTAAKAAAKKTTAKKAAKKAGPKPRTGSLFKTMDISTVTLDDALKL 837 Query: 755 -PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRY 813 +P +S ++G G +L K ++R+ EE F L E L+ Sbjct: 838 LSLPRVVGVDPESGDEITAQNGRYGPYLK-----KGTDSRSLTSEE-QLFSITLDEALKI 891 Query: 814 LADAPQQDP----------------EGNKTMVRFSRKT 835 ++ ++ G +++ R Sbjct: 892 YSEPKRRGRQAAAPPLRDLGKEDSVSGKPMVIKDGRFG 929 >UniRef50_Q9X3X7 DNA topoisomerase 1 n=7 Tax=cellular organisms RepID=TOP1_ZYMMO Length = 1217 Score = 617 bits (1590), Expect = e-175, Method: Composition-based stats. Identities = 244/673 (36%), Positives = 352/673 (52%), Gaps = 67/673 (9%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LV+VESPAKAKTI KYLGS Y V +S GHIRDLP+ Sbjct: 7 KLVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDG--------------------- 45 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 V+P + + ++ P K + ++ +++D + LATD DREGEAI+WH+ Sbjct: 46 --------SVNPDNGFSMVWQNYPDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHI 97 Query: 124 ---REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 + RV FN ITK A+ A P +L+ D +NA ARR +D +VG+ +S Sbjct: 98 LELLKTKKLLPDDVERVTFNAITKAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTLS 157 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP--SGEALALQV 238 P+LW+K+ SAGRVQSVA+RLVV+RE+EI+ F P+E+W V+A + +Q Sbjct: 158 PILWRKLPGAKSAGRVQSVALRLVVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQW 217 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 Q + +K Q +AA S +E ++V E KP + P PF TSTLQQ A+ +LG Sbjct: 218 RGQKLEKLSIADKTQAEAAQSDVESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKLG 277 Query: 299 FGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK 358 F TM +AQ LYE G ITYMRTD + + A+ R I+ + Y+P+ P QY K Sbjct: 278 FAASHTMRLAQSLYEEGLITYMRTDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQVK 337 Query: 359 -ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVG- 416 +N+QEAHEAIRP+D + + D +LY+LIW++ +A QM AK + TT+ + Sbjct: 338 AKNAQEAHEAIRPTDFSRDKAA----SGDHARLYELIWKRALASQMASAKLERTTVDLTD 393 Query: 417 -AGDFRLKARGRILRFDGWTKVMPALRKG--------DEDRILPAVNKGDALTLVELTPA 467 G L+ G+++ F G+ + + LP + GDA E+ Sbjct: 394 GTGQNVLRVTGQVVLFSGFLTLYEESADDNANDRDGKEGRARLPLLRAGDAPLKKEVRAD 453 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 QHFT+PP R+SEASLVK++E GIGRPSTYAS+I ++DR YV +E RF + G ++T Sbjct: 454 QHFTQPPPRYSEASLVKKMEDLGIGRPSTYASVIQVLKDRAYVTLERNRFIPSEAGRLLT 513 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 LE F ++YDFTA +E+SLD+++ A+W+ VLD F+ DF + + + Sbjct: 514 AFLERFFERYVSYDFTAGLEDSLDEISGGRADWQKVLDAFWHDFKPKTAEVMEQQPSAIT 573 Query: 588 RPNQMVLTSIDCPTCGRK-------------MGIRTASTGVFLGCSGYALPPKERCKTTI 634 L P G + ++ G F+ CS Y CK T Sbjct: 574 AELDKFLEPWLFPDKGDGHDPRECPSCHTGRLALKGGRFGAFIACSNYP-----ECKYTR 628 Query: 635 NLVPENEVLNVLE 647 + ++ E Sbjct: 629 GFGQGEDGVDDNE 641 Score = 54.7 bits (130), Expect = 2e-05, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 24/71 (33%), Gaps = 2/71 (2%) Query: 752 KEDPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEK 810 + C L+ G G F+A + +P+ + TR E D P Sbjct: 586 PDKGDGHDPRECPSCHTGRLALKGGRFGAFIACSNYPECKYTRGFGQGEDG-VDDNEPVL 644 Query: 811 LRYLADAPQQD 821 L Y+ + D Sbjct: 645 LGYMPENSDDD 655 Score = 42.8 bits (99), Expect = 0.060, Method: Composition-based stats. Identities = 27/201 (13%), Positives = 50/201 (24%), Gaps = 26/201 (12%) Query: 635 NLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEI 694 N ++ + E+ A RR + G + +++ V + Sbjct: 920 NDTAASKADEQAKEEEESRKARAVTRRTGRFGPYIQLGEGKNAKRVSVPRDVN--PREVD 977 Query: 695 EEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEEC------------------ 736 R+ I + G + GR+G Y+ C + Sbjct: 978 FSLASRLLALPREIGLHPESGKMIIAGTGRYGPYLNCDGKYARLSSTEELLDIDIDRAVV 1037 Query: 737 KNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPL 796 K G ++ L +G G ++ ET A L Sbjct: 1038 KLAEAAQNKGRTGATLSREPLKVFGDSPVTEKPVQLMNGRYGPYVTDG------ETNASL 1091 Query: 797 VEELYRFRDRLPEKLRYLADA 817 ++ E L L Sbjct: 1092 PKDTTPESLTFEEALALLEAR 1112 >UniRef50_D0D7V2 DNA topoisomerase n=1 Tax=Citreicella sp. SE45 RepID=D0D7V2_9RHOB Length = 918 Score = 616 bits (1588), Expect = e-174, Method: Composition-based stats. Identities = 294/914 (32%), Positives = 438/914 (47%), Gaps = 145/914 (15%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M +V+VESPAKAKTINKYLGSDY V +S GH+RDLP Sbjct: 1 MP--VVVVESPAKAKTINKYLGSDYTVLASYGHVRDLPAKDG------------------ 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 VD H++E +E+ K V+ + + + + + LATD DREGEAI+ Sbjct: 41 -----------SVDTDHDFEMTWEIANDSRKHVAAIAEALKNDNSLILATDPDREGEAIS 89 Query: 121 WHLREVIGGDDAR-----YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 WHLRE + + SRV FN ITK+A+ +A P E++ V A ARR +D +V Sbjct: 90 WHLREALTKRRSIKKDTAVSRVTFNAITKSAVTEAMQNPREIDAPLVEAYLARRALDYLV 149 Query: 176 GYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALA 235 G+ +SP+LW+K+ SAGRVQSV +RL+VERE EI+AF P E+W++ A +TP G+ Sbjct: 150 GFNLSPVLWRKLPGARSAGRVQSVCLRLIVEREMEIEAFRPREYWQIKALLSTPRGQEYE 209 Query: 236 LQVTHQNDKP---FRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 ++T K F N Q + AV + + + E +P+T P APF+TSTLQQ Sbjct: 210 ARLTVLGGKKLDRFDIGNATQAELAVQAVASRKLKIDSVEARPSTRNPSAPFMTSTLQQE 269 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 AS + G G + M AQRLYEAG+ITYMRTD +++ +A+ R I+D +GK+Y+P SP Sbjct: 270 ASRKFGMGARACMNAAQRLYEAGHITYMRTDGIDMAPEAITACRDAIADRYGKEYVPGSP 329 Query: 353 NQYASK-ENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 Y +K +N+QEAHE IRP+D+ A SLK E D +KLY LIW++ +ACQM A+ + T Sbjct: 330 RIYKNKAKNAQEAHECIRPTDMTRDAASLKLREDDQRKLYDLIWKRTLACQMEAARLERT 389 Query: 412 TLTVGAGDFR--LKARGRILRFDGWTKVMPALRK---GDEDRILPAVNKGDALTLVELTP 466 T+ + + D + L+A G+++ FDG+ KV R D++ LP + +G+ + T Sbjct: 390 TVEILSEDRQVGLRATGQVVLFDGFLKVYEEGRDDVSDDDENRLPQIMEGEPAAFAKATL 449 Query: 467 A--------------------------------------QHFTKPPARFSEASLVKELEK 488 Q T+PP R++EA+LVK +E+ Sbjct: 450 QAQYDKASDKAEDVVEDAPAGMQKSSAAVLSDNGAVLATQSHTQPPPRYTEATLVKRMEE 509 Query: 489 RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN 548 GIGRPSTYAS+I+TIQDR YVR E R + E G IVT L FR+ + Y+FTA++EN Sbjct: 510 LGIGRPSTYASVITTIQDREYVRKEQNRLFPEDKGRIVTIFLLNFFRKYVGYEFTAELEN 569 Query: 549 SLDQVANHEAEWKAVLDHFFSDFTQQL------------DKAEKDPEEGGMRPNQMVLTS 596 LD+V+ E ++K++L F+ DF+ + D ++ P + Sbjct: 570 ELDEVSAGEMDYKSLLAKFWRDFSAAIGETSELRISEVLDVLDEALAPQLYPPREDGSDP 629 Query: 597 IDCPTCGRK-MGIRTASTGVFLGCSGYALPPKERCKTTINLVPEN--EVLNVLEGEDAET 653 CP CG+ + ++T+ TG F+GC Y C T + E +L + + Sbjct: 630 RICPKCGQGRLHLKTSRTGGFVGCGNYP-----ECTYTRPIAGEGADGEERLLGSHEGDE 684 Query: 654 NALRAKRRCPKC---------GTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 L+A R P + L G +P E + Sbjct: 685 VWLKAGRFGPYVQRGEPTPENKKPPRASLPKKGGAFLP-GWSPD---DMTLEKAVTLLTL 740 Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTNEECK-------------NTRKILRNGEVAPP 751 + + G E+ +GRFG ++ + + + E+ Sbjct: 741 PRVVGMHPE-GGEVKSNLGRFGPFIMHQLPDEEKPVYVNLKEFQEVFEIGMNHAVELLAE 799 Query: 752 KEDPVPLPELPCEKS---------DAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYR 802 K K+ + +G G ++ K + A L ++ Sbjct: 800 KRANPGRGRGGAAKTLKDLGEHPDGGKIAVYEGRYGPYV------KWEKVNATLPKDTEP 853 Query: 803 FRDRLPEKLRYLAD 816 L L +A+ Sbjct: 854 ADVTLETALALIAE 867 >UniRef50_O69548 DNA topoisomerase 1 n=28 Tax=Actinomycetales RepID=TOP1_MYCLE Length = 947 Score = 615 bits (1587), Expect = e-174, Method: Composition-based stats. Identities = 286/932 (30%), Positives = 421/932 (45%), Gaps = 130/932 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 + LVIVESP KA+ ++ YLGS Y+V+SS GHIRDLP + + Sbjct: 15 PRRLVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAK-------------- 60 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + R+GV+ ++E Y + P K+ V+ELK L + D +YLATD DREGEAIAW Sbjct: 61 -FKSEPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAW 119 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL + + R+VF+EIT++AI A P EL+ID V+AQ+ RR +DR+ GY VSP Sbjct: 120 HLMQTLKPR-VPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSP 178 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT------TPSGEALA 235 +LWKK+A LSAGRVQSVA R++V+RER+ AF +W++ A T Sbjct: 179 VLWKKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFV 238 Query: 236 LQVTHQND---------------------KPFRPVNKEQTQAAVSLLEKARYSVLEREDK 274 ++T + ++ + L A+ +V E+K Sbjct: 239 ARLTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEK 298 Query: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNM 334 T +P PF+TSTLQQ A +L F ++TM +AQRLYE GYITYMRTDST LS+ A+N Sbjct: 299 LYTRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINA 358 Query: 335 VRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESL--KDMEADAQKLY 391 R +G++Y+ +SP QY K +N+QEAHEAIRP+ +++ D ++Y Sbjct: 359 ARTQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIY 418 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGA----GDFRLKARGRILRFDGWTKVMPALRKG--- 444 +L+WR+ VA QM A+ + +L + A GR L F G+ K Sbjct: 419 ELVWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAG 478 Query: 445 ----DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASI 500 D +R LP + G L +++LTP H T PPAR++EASLVK LE+ GIGRPSTY+SI Sbjct: 479 GEADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSI 538 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 I T+QDRGYV+ + + VT LE++F L++YDFTA ME+ LD++AN + Sbjct: 539 IKTVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQR 598 Query: 561 KAVLDHFFSDFTQQLDKAEKD---------PEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 L++F+ + + G+ ++ + GR + +R Sbjct: 599 TNWLNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVG 658 Query: 612 STGVFL-----GCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 TG +L G G P + T L P+ L V E A + R P+ G Sbjct: 659 KTGPYLERLLAGDDGELTPQRANLNGT--LTPDELTLEVAEELFATPHEGRVLGVDPETG 716 Query: 667 TAMDSY--------------------------LIDPKRKLHVCGNNPTCDG--------- 691 + + K + P Sbjct: 717 HEIVAKDGRYGPYVTEVLPKHDDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDL 776 Query: 692 -YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA-------CTNEECKNTRKIL 743 E ++ + G E+ + GR+G Y+ T E+ + Sbjct: 777 QTITLEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLD 836 Query: 744 RNGEVAPPKE--------DPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAP 795 ++ + P S +++DG G ++ ET A Sbjct: 837 EALKIYAEPKRAGRQSTSPPPLRELGTDPTSGKPMLIKDGRFGPYVTDG------ETNAS 890 Query: 796 LVEELYRFRDRLPEKLRYLADAPQQDPEGNKT 827 L + LAD + P Sbjct: 891 LRKGDDVVSITDERAAELLADRRARGPVKRPA 922 >UniRef50_C7MGF4 DNA topoisomerase n=5 Tax=Actinobacteridae RepID=C7MGF4_BRAFD Length = 904 Score = 615 bits (1585), Expect = e-174, Method: Composition-based stats. Identities = 269/916 (29%), Positives = 415/916 (45%), Gaps = 121/916 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G+ LVIVESPAKA+TI +YLG +Y VK+SVGHIRD+P Sbjct: 4 GRHLVIVESPAKARTIGRYLGEEYDVKASVGHIRDIPVPRD----------------LPA 47 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + + + GVD + ++ +Y V P K+K V+ELK+ + AD +YLATD DREGEAIAW Sbjct: 48 EMKKGPYGKFGVDVENGFDPYYIVSPDKKKTVAELKKALKDADTLYLATDEDREGEAIAW 107 Query: 122 HLREVIGGDDA-RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 HL E + + R+VF+EITK+AIR A +++ V+AQ+ RR +DR+VG+ +S Sbjct: 108 HLLETLKPKKSLPVKRMVFHEITKDAIRAALENTRDIDASLVDAQETRRILDRLVGFELS 167 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA---LALQ 237 P+LW+KI LSAGRVQSVA RLVVERERE AFV ++W++ + G + Sbjct: 168 PVLWRKIKPSLSAGRVQSVATRLVVERERERMAFVAADYWDITGTFAAEGGADGTQFTAK 227 Query: 238 VTHQND-------------------KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 + + K + E TQ V +L A +V E KP T Sbjct: 228 IATVDGARVATGSDFADDGTLKPRAKNAAVLTAESTQTLVEVLGDAPATVTALESKPYTR 287 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY 338 +P APF TS+LQQ AS +L G ++ M +AQ LYE GYITYMRTDS LS +A+ R Sbjct: 288 RPAAPFTTSSLQQEASRKLRLGARQAMRVAQSLYENGYITYMRTDSVTLSGEAIRASRAQ 347 Query: 339 ISDNFGKKYLPESPNQYASKE-NSQEAHEAIRPSDVNVM--AESLKDMEADAQKLYQLIW 395 ++ +G +++P+ P Y +K +QEAHEAIRP+ + AE + D +LY+LIW Sbjct: 348 AAELYGSQFVPDKPRYYQNKSQAAQEAHEAIRPAGDHFRTPAEVAGQLSGDEFRLYELIW 407 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDF----RLKARGRILRFDGWTKVM---------PALR 442 ++ +A QM AK ++T+ + + +A G ++ F G+ Sbjct: 408 KRTIASQMADAKGTTSTVELLLENEGRAATFRAAGTVITFRGFLAAYEEGRDASRYKDDE 467 Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 + D+ LP + +G L LTP H T PP R++EASLV+ LE RGIGRPSTYAS ++ Sbjct: 468 EKGGDKRLPQMEEGQTLDTRALTPDGHTTTPPPRYTEASLVRALEDRGIGRPSTYASTVA 527 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 T+QDRGYV V LEE+F ++YDFTAQME LD++A + Sbjct: 528 TVQDRGYVLRRGTALVPSWTAFAVVRLLEEHFGPFIDYDFTAQMEQQLDRMAQGDLARSE 587 Query: 563 VLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGY 622 L +F+ + ++ +I+ G + +R G ++ + Sbjct: 588 YLKNFY---LSDGTDGPIGLKPMVDDLGEIDARAINSIEIGEGITLRVGRYGAYV--EQF 642 Query: 623 ALPPKER---------CKTTINLVPENEVLNVLEGE-DAETNALRAKRRCPKCGTAMDSY 672 + + P+ + + + + R P+ G + + Sbjct: 643 PRDEDGELIEGADPRRANVSDEVAPDELTVEKAKEMLERAKDDGRVLGTDPETGHEIVAK 702 Query: 673 LIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEK------------------- 713 +V P + ++ + + Sbjct: 703 DGRYG--PYVTEVLPEAQTADGKKVPKSKQPKPRTGSLLKSMDLSTVTLEDALKLLSLPR 760 Query: 714 ------CGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKED------------- 754 G+E+ + GR+G YM + ++ + + + + Sbjct: 761 VVGTAADGTEITAQNGRYGPYMK-KGTDSRSLETEEQIFSITLEEAEKIYAQPKTRGRAA 819 Query: 755 --PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPE-KL 811 P S+ V++DG G ++ T + + + + + Sbjct: 820 AKPPLKELGTDPTSEKPIVIKDGRFGPYIT-------DGTTNVSLRATEKVEEITEKVAI 872 Query: 812 RYLADAPQQDPEGNKT 827 LA+ + P K Sbjct: 873 EKLAEKRAKGPAKKKA 888 >UniRef50_C4FH65 DNA topoisomerase n=1 Tax=Bifidobacterium angulatum DSM 20098 RepID=C4FH65_9BIFI Length = 996 Score = 610 bits (1574), Expect = e-173, Method: Composition-based stats. Identities = 281/953 (29%), Positives = 410/953 (43%), Gaps = 135/953 (14%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LVIVESP KA+ I+ YLG Y V +SVGHIRDL Sbjct: 4 GSKLVIVESPTKARKISGYLGDGYTVMASVGHIRDLAQPSQ-----------------VP 46 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + GVD ++ +Y V K K V++LK +KAD +YLATD DREGEAIAW Sbjct: 47 AADKEHYGKFGVDVNDGFKPYYIVGADKRKTVADLKSALKKADELYLATDEDREGEAIAW 106 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL E + R+VF+EITKNAI+Q+ + +++ D V+AQ+ RR +DR+ GY +SP Sbjct: 107 HLVETLKP-KVPVKRMVFHEITKNAIKQSLEQTRDVDADMVDAQETRRILDRLYGYELSP 165 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS----------- 230 +LW+K+ GLSAGRVQSVA RL+VERERE AF +W++ A + Sbjct: 166 VLWRKVGPGLSAGRVQSVATRLIVERERERMAFTRASYWDIVAKLAAANTQGERVGFDAR 225 Query: 231 -----GEALALQVTHQNDKPFRP---------VNKEQTQAAVSLLEKARYSVLEREDKPT 276 G L D P +++ A LE A ++V+ E KP Sbjct: 226 MVSLGGRRLVGSKDFGADGKLTPAGFADNVCQLSQTDAAAVAQELEHAPFTVMSMESKPY 285 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 +P PF TSTLQQ A RLG + TM AQ LYE GYITYMRTDS LS +A+ R Sbjct: 286 RRRPLPPFTTSTLQQTAGNRLGMSSRATMRAAQGLYENGYITYMRTDSVTLSSEAIAAAR 345 Query: 337 GYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLYQL 393 + +FGK +L ++P QY +K +QEAHE IRP+ + +D KLY L Sbjct: 346 NAVEYHFGKSFLSDAPKQYDTKTAGAQEAHECIRPAGARFHDPDELATRVPSDQLKLYTL 405 Query: 394 IWRQFVACQMTPAKYDSTTLTVG-----AGDFRLKARGRILRFDGWTKVMPAL------- 441 IW++ +A QM A + T+ + G+ +A G ++ F G+ K Sbjct: 406 IWQRTLASQMADATGSTATVKISAPAGGHGEALFQASGTVIDFPGFMKATGEQHHAAKQG 465 Query: 442 ----RKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTY 497 + + LP ++ G L + ++ H T+PPAR++EASLVK LE + IGRPSTY Sbjct: 466 GRKGENAEGNASLPPMSAGQRLDVADVQADGHETQPPARYTEASLVKTLEAKEIGRPSTY 525 Query: 498 ASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHE 557 ASIISTI DRGYV R + V LE F +L++Y FTA MEN LDQ+A+ + Sbjct: 526 ASIISTIIDRGYVYERGRALIPSWLAFAVVKLLETKFPKLVDYQFTADMENGLDQIAHGK 585 Query: 558 AEWKAVLDHFF----SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAST 613 + L F+ D+A + + + ++ +I+ G + +R Sbjct: 586 QTGRDWLTRFYFGDGDAAAANADEAHEGLQRQVAQLGEIDARAINTIEIGDGLHVRVGRY 645 Query: 614 GVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETN---ALRAKRRCPKCGTAMD 670 G +L + + + + L V D N R + PK G ++ Sbjct: 646 GPYLEDMAHTDEDGNPKRAALPDTIAPDELTVDVARDLIENHSGGPRELGKDPKTGGTVE 705 Query: 671 SYLIDPKRKL----------------HVCGNNPTCDGYEIEEGEFR----------IKGY 704 + + P + + + Sbjct: 706 VRNGRFGPYVALLPVEGAVSPAPAKGSKKSDAPRPKMASLFKTMSPESITLDDALRLLSL 765 Query: 705 DGPIVECEKCGSE--------MHLKMGRFGKYMACTNEE--------------------- 735 + E+ +E + GR+G Y+ T + Sbjct: 766 PREVGSYEEANAETGEISTSTVAANNGRYGPYLTKTKADGSTETRSLNSEDEIFTVDIET 825 Query: 736 CKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAP 795 K + P +S V+R+G G++L ET Sbjct: 826 AKALFAQPKFRGRGRGAAKPPIRELGTDPESKKPVVIREGRFGMYLTDG------ETNRT 879 Query: 796 LVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKT-KQQYVSSEKDGK 847 L + + R LA+ P R R+ ++ ++ + GK Sbjct: 880 LPRQYDPATITPEDAYRILAEKRAMGPTKK----RGGRRGAAKKSIARKTSGK 928 >UniRef50_B8DVL2 DNA topoisomerase n=14 Tax=Actinobacteridae RepID=B8DVL2_BIFA0 Length = 986 Score = 608 bits (1568), Expect = e-172, Method: Composition-based stats. Identities = 288/946 (30%), Positives = 401/946 (42%), Gaps = 129/946 (13%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 G LVIVESPAKAK I YLG Y V +SVGHIRDL Sbjct: 4 GSKLVIVESPAKAKKIGGYLGDGYTVLASVGHIRDLAQPSQ-----------------VP 46 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + A + GVD ++ +Y V P K+K VSEL+ A +YLATD DREGEAIAW Sbjct: 47 ADEKAKFGKFGVDVNDGFKPYYIVGPEKKKTVSELRSALRNASELYLATDEDREGEAIAW 106 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL + + R+VF+EIT AIR + E++ + V+AQ+ RR +DR+ GY +SP Sbjct: 107 HLVQTLKP-KVPVKRMVFHEITPEAIRASLEHTREVDNNMVDAQETRRVLDRLYGYELSP 165 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV--- 238 +LW+K+ GLSAGRVQSVA RL+VERERE AFV +W+V A+ P Sbjct: 166 VLWRKVGPGLSAGRVQSVATRLIVERERERMAFVRAPYWDVVATLCAPDALGEPTDFESR 225 Query: 239 -----------THQNDKPFRPVN-----------KEQTQAAVSLLEKARYSVLEREDKPT 276 + + + Q L AR+ V+ E KP Sbjct: 226 MIALNGTRLATSKDFKSDGTLTDAARTDGVVQLGESQAGDLADALADARFRVISVEKKPY 285 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 +P PF TST+QQAA RLG ++TM AQ LYE GYITYMRTDS LS +A+ R Sbjct: 286 RRRPQPPFTTSTMQQAAGNRLGMSSRQTMRAAQSLYENGYITYMRTDSVTLSHEAIEAAR 345 Query: 337 GYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSD-VNVMAESLKDMEADAQKLYQLI 394 +S NFG +YL E P QYA+K +QEAHE IRP+ L + D KLY LI Sbjct: 346 ESVSKNFGSQYLSEKPKQYATKTAGAQEAHECIRPAGSHFRDPSQLATLPPDQLKLYTLI 405 Query: 395 WRQFVACQMTPAKYDSTTLTVGA-----GDFRLKARGRILRFDGWTKVMPA----LRKGD 445 W++ +A QM A + T A G+ ++ G ++ F G+ +V +KG+ Sbjct: 406 WQRTLASQMADATGSTATARFAASAGGLGEATFQSSGTVIEFPGFMRVTGERGGSGKKGE 465 Query: 446 EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQ 505 E LP + + L + H T+PPAR++EASLVK LE + IGRPSTYA+IISTI Sbjct: 466 ESASLPPLAESAELPAKSVLADGHETQPPARYTEASLVKTLEAKEIGRPSTYANIISTII 525 Query: 506 DRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLD 565 DRGYV R + VT LE F + ++Y FTA MEN LDQ+A+ + L Sbjct: 526 DRGYVYERGRALIPSWLAFAVTRLLETKFPKYVDYQFTADMENGLDQIAHGNETGREWLT 585 Query: 566 HFF----SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG 621 F+ +D + D+A + + + ++ I+ G + +R G +L + Sbjct: 586 QFYFGSGADSARSADEAHEGLQRQVAQLGEIDAREINTIPIGDGIHVRVGRYGPYLEDTK 645 Query: 622 YALPPKERCKTTINLVPENEVLNVLEGED---AETNALRAKRRCPKCGTAMDSYLIDPKR 678 + +I + L V E + R P G ++ Sbjct: 646 DLDAEGNPKRASIPDTIAPDELTVGEARKLIASNAGGPRVLGTDPATGGTVEVRNGRFGP 705 Query: 679 KL----------------------------HVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710 + P + + E Sbjct: 706 YVALVAPESAHESAPTGKKKAAEPKPKMASLFKSMKPETVTLDDALRLLSLPRTVCTYDE 765 Query: 711 -CEKCGSEMHL----KMGRFGKYMACTNEECK---------------------NTRKILR 744 K G + + GR+G Y+ T + Sbjct: 766 VDAKTGETVSVTISASNGRYGPYLTKTRADGGASETRSLESEDAIFTVDETHAQALFAQP 825 Query: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFR 804 P P +S +++G F + ET L ++ Sbjct: 826 KYGRGRGAAKPPLRTLGPDPESKREVSIKEG----FYG--AYITDGETNRSLPKQYDPKT 879 Query: 805 DRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATG 850 + R LA+ P R RK K S++ GK T Sbjct: 880 ISAEDAFRLLAEKRAAGPSK-----RRGRKGK---ASAKSTGKGTA 917 >UniRef50_A5CF60 DNA topoisomerase n=2 Tax=Orientia tsutsugamushi RepID=A5CF60_ORITB Length = 788 Score = 608 bits (1568), Expect = e-172, Method: Composition-based stats. Identities = 267/771 (34%), Positives = 406/771 (52%), Gaps = 80/771 (10%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+IVESPAKAKTINKYLGSD+ V +S GH+RDL Sbjct: 2 KLLIVESPAKAKTINKYLGSDFQVVASYGHVRDL-------------------------- 35 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 L V P ++ YE+ P + + + LA+K++ IYLATD DREGE+I+WH+ Sbjct: 36 ---LAKAGSVLPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATDPDREGESISWHI 92 Query: 124 REVIGGDD--ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 EV+ A + R++FNEITK AI A +P ++N++ VNAQQARR +D +VG+ +SP Sbjct: 93 VEVLKEKKIFANFKRIIFNEITKKAIGDALQQPRDINLNLVNAQQARRSLDYLVGFSLSP 152 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLW+K+ SAGRVQSV +RL+ ERE EI F+ +E+W + + E + ++ Sbjct: 153 LLWRKLPGCKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKLIEF 212 Query: 242 ND---KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 + + F N+ Q Q V +E ++ V++ K P PFITS+LQQ A+ +LG Sbjct: 213 DGNKLEKFSITNQSQAQDIVKNIENQQFKVIDITRKQRKKSPPPPFITSSLQQEAAGKLG 272 Query: 299 FGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 F KKTM +AQ+LYE ITYMRTDS LS+D ++ R +IS +FG YLP Sbjct: 273 FTAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNFISSSFGNNYLPR 332 Query: 351 SPNQYASK-ENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMTPAKY 408 + SK +N+QEAHEAIRP ++N+ E L +E D KLY+LIW++ VACQM Sbjct: 333 QIRAFKSKVKNAQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQRTVACQMENVIL 392 Query: 409 DSTTLTVGAGD--FRLKARGRILRFDGWTKVMPALRKGDEDR-ILPAVNKGDALTLVELT 465 + ++ + + KA G + FDG+ KV + +E++ +LP +++ + + + + Sbjct: 393 NLESINFASFNQLHVAKATGSTIAFDGFYKVYKEINDEEENKKLLPNLSQNEVMQVKNIL 452 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 P QHFT+PP R+SEA+LVK LE GIGRPSTYA+IIS +Q+R YV ++ +RF + G + Sbjct: 453 PKQHFTEPPPRYSEATLVKTLEDLGIGRPSTYATIISVLQERDYVILDQKRFIPQNKGRL 512 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 VT L F++ + YDFTA++E+ LD +A W+ +L +F++ F + + E+ Sbjct: 513 VTAFLTAFFKKYVEYDFTAKLEDQLDSIAKGMIGWQEILKNFWTGFNNNVQEIEQYKITD 572 Query: 586 GMRPNQMVLTSIDCPTCG-------------RKMGIRTASTGVFLGCSGYALPPKERCKT 632 + + +L++ P K+ ++ + G FL C+ Y C Sbjct: 573 IIPQIETLLSNFLFPVQNGETDHKLCTLCKVGKLSLKLSKYGAFLACNNYPS-----CNF 627 Query: 633 TINLVPENEVLNVLE--------GEDAETNALRAKRRCP-----KCGTAMDSYLIDPKRK 679 T N+ E + L G + + P + G + PKR Sbjct: 628 TRNIAAAFENNDNLPKGKNNKAIGYSDDMQKTIYLKEGPFGWYIQAGEDSTNKNDKPKRV 687 Query: 680 LHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 ++ E ++ I E+ + +GR+G Y+ Sbjct: 688 PISVISSS--PQDITLETAVKLLALPKVIGLNPNTNKEITVAVGRYGPYLK 736 Score = 43.9 bits (102), Expect = 0.024, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 29/99 (29%), Gaps = 19/99 (19%) Query: 754 DPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLR 812 C L+ G FLA N +P TR + D LP+ Sbjct: 589 QNGETDHKLCTLCKVGKLSLKLSKYGAFLACNNYPSCNFTRNIAA--AFENNDNLPKG-- 644 Query: 813 YLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGW 851 + NK + K Y+ K+G GW Sbjct: 645 ----------KNNKAIGYSDDMQKTIYL---KEGPF-GW 669 >UniRef50_Q1UZD4 DNA topoisomerase n=4 Tax=Bacteria RepID=Q1UZD4_PELUB Length = 863 Score = 608 bits (1568), Expect = e-172, Method: Composition-based stats. Identities = 283/892 (31%), Positives = 420/892 (47%), Gaps = 115/892 (12%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LV+VESPAKAKTINKYLG DY+V +S GHIRDLP+ Sbjct: 2 NLVVVESPAKAKTINKYLGDDYIVLASYGHIRDLPSKNG--------------------- 40 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 VDP +N++ +EV +K + E+ A+ + I LATD DREGEAIAWH+ Sbjct: 41 --------SVDPENNFKMEWEVDSFSKKYLKEITDAAKISSKIILATDPDREGEAIAWHV 92 Query: 124 REVIGGDD----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 +E + RVVFNEITK A+ P ++ V+A ARR +D +VG+ + Sbjct: 93 KEYLNEKKLIKDKHIERVVFNEITKKAVIHGIENPRQIEPLLVDAYMARRALDYLVGFNI 152 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SP+LW K+ SAGRVQSVA++L+ ERE EI+ F PEEFW + ++ +T Sbjct: 153 SPILWTKLPGSKSAGRVQSVALKLITEREHEIELFDPEEFWTLSIQFNDSDKNSILASIT 212 Query: 240 HQNDK---PFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 NDK F NK + A+ ++ +++ + K P PF TSTLQQ +S R Sbjct: 213 QLNDKKIEKFSFKNKAEIDKAMEEVKSKNFNINDISSKVVNRNPSGPFTTSTLQQVSSGR 272 Query: 297 LGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LGFG +TM +AQ+LY+ G ITYMRTD TNLS DA++ R YI + FG +Y+ Sbjct: 273 LGFGASRTMQIAQKLYQGIEIDGETIGLITYMRTDGTNLSTDAIDTFRKYIKNEFGDEYV 332 Query: 349 PESPNQYASK--ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTP 405 P++ Y+ K +N+QEAHEAIRP+D+ +++K + D KLY LIW + ++ QM P Sbjct: 333 PDNAASYSGKKAKNAQEAHEAIRPTDIMRAPDTVKKYLSPDQHKLYDLIWSRALSSQMKP 392 Query: 406 AKYDSTTLTVGAGDF--RLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVE 463 A++D T+T+ + D KA G +++FDG+ KVM +K D++ ILP +NKG + + Sbjct: 393 AQFDRNTITISSDDNGTICKASGSVIKFDGFLKVMKDTKKDDDEDILPEMNKG-PVNIES 451 Query: 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMG 523 L QHFT+PP R+SEASLVK+LE+ GIGRPSTYASIIS I RGY N+RF+ G Sbjct: 452 LLDEQHFTQPPPRYSEASLVKKLEELGIGRPSTYASIISVISTRGYAETINKRFHPTDRG 511 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPE 583 ++++ LE+ F + ++Y+FTA +EN LD + + W VL+ F+ DF Q + ++ Sbjct: 512 KLISAFLEKLFSKYVDYNFTASLENQLDDITTGKEGWIKVLELFWKDFNQNVSDVKEKRT 571 Query: 584 E--------------GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 + + G + G F+GCS Y Sbjct: 572 REVLDLLNDSLGSLIFERDADGNINRQCKLCDSGSLSLKNSFRGGAFIGCSNYP-----D 626 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKR----RCPKCGTAMDSYLIDPKRKLHVCGN 685 CK T L E + + G + I+ ++ + Sbjct: 627 CKFTRPLSKAKAAAQSQLAEPKFIGKHENGNDMYLKNGRFGPYLQYEKIEEIKEKIIIET 686 Query: 686 NPT------------------------CDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLK 721 + + + + ++ L Sbjct: 687 KKKKKTKKKKIEKEDNNLRNVSIPKGITLDSVDLDRAKFLCSLPKSLGINPENQKDIILN 746 Query: 722 MGRFGKYMACTNEECK-------NTRKILRNGEVAPPKEDPVPLPEL-----PCEKSDAY 769 GRFG Y+ C N+ + + + R + + + + Sbjct: 747 SGRFGPYLKCENKSARIENVEEIFSIGLNRAITLIAEAKPGRMSASIIKDLGEHPEDKKP 806 Query: 770 FVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQD 821 + G G + K + A + EE + E L + + D Sbjct: 807 VRVMKGQYGP------YIKYKSLNATIPEEKDPLELNMEEALILIEKRKEYD 852 >UniRef50_Q9ZMV7 DNA topoisomerase 1 n=47 Tax=Epsilonproteobacteria RepID=TOP1_HELPJ Length = 736 Score = 607 bits (1565), Expect = e-172, Method: Composition-based stats. Identities = 268/797 (33%), Positives = 407/797 (51%), Gaps = 82/797 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+IVESPAKAKTI +L +Y V +S GH+RDL K Sbjct: 2 KHLIIVESPAKAKTIKNFLDKNYEVVASKGHVRDL----------------------SKF 39 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 G ++ G + +Y V +++V ++ +L++KA Y+ATD DREGEAI +H Sbjct: 40 ALGIKIDETG------FTPNYVVDKDHKELVKQIIELSKKASITYIATDEDREGEAIGYH 93 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 + +IGG Y R+VF+EIT+NAI P ++++ +VNAQQARR +DR+VG+ +S L Sbjct: 94 VACLIGGKLESYPRIVFHEITQNAILNVLKTPRKIDMFKVNAQQARRLLDRIVGFKLSSL 153 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 + KI +GLSAGRVQS A++LV++RE+EI+ F P ++ +DA P EA + Sbjct: 154 IASKITKGLSAGRVQSAALKLVIDREKEIRPFKPLTYFTLDALFE-PHLEAQLISYKGNK 212 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 K +++++ Q + LEK Y + K S PF+TSTLQQ+AS+ LGF Sbjct: 213 LKAQELIDEKKAQEIKNELEKESYIISSIIKKSKKSPTPPPFMTSTLQQSASSLLGFSPT 272 Query: 303 KTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQ 354 KTM +AQ+LYE G ITYMRTDS N++++A+ R I ++GK YLP Sbjct: 273 KTMSIAQKLYEGVATPQGVMGVITYMRTDSLNIAKEALEEARAKILKDYGKDYLPPKAKV 332 Query: 355 Y-ASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 Y + +N+QEAHEAIRP+ + + +LKD ++ + KLY LI+++F+A QM A ++S + Sbjct: 333 YSSKNKNAQEAHEAIRPTSIILEPNALKDYLKPEELKLYTLIYKRFLASQMQDALFESQS 392 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 + V KA GR L FDG K++ D+D++LP + + D + L +L H T+ Sbjct: 393 VVVACEKGEFKASGRKLLFDGHYKILGN---DDKDKLLPNLKENDPIKLEKLESNAHVTE 449 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PPAR+SEASL+K LE GIGRPSTYA IS +Q+R Y++VE ++ A + V + LE+ Sbjct: 450 PPARYSEASLIKVLESLGIGRPSTYAPTISLLQNRDYIKVEKKQISALESAFKVIEILEK 509 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 +F E+++ F+A +E LD +A ++A+++ VL F+ F +++ +K+ Sbjct: 510 HFEEIVDSKFSASLEEELDNIAQNKADYQQVLKDFYYPFMDKIEAGKKNII----SQKVH 565 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 T CP CG ++ + + G F+ C+ Y +CK N+ Sbjct: 566 EKTGQSCPKCGGELVKKNSRYGEFIACNNYP-----KCKYIKQTENANDEAKQ------- 613 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 C KCG M C N P C + + V+C Sbjct: 614 -------ELCEKCGGEMVQKFS-RNGAFLACNNYPECKNTKSLKNTPNA-KETIEGVKCP 664 Query: 713 KCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFV 771 +CG ++ LK + G + C N +C CEK Sbjct: 665 ECGGDIALKRSKKGSFYGCNNYPKCNFLSNHKP--------------INKRCEKCHYLMS 710 Query: 772 LRDGAAGVFLAANTFPK 788 R + Sbjct: 711 ERIYRKKKAHECIQCKE 727 Score = 59.3 bits (142), Expect = 6e-07, Method: Composition-based stats. Identities = 10/72 (13%), Positives = 22/72 (30%) Query: 739 TRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVE 798 + G+ + C K V ++ G F+A N +PK + + Sbjct: 548 FMDKIEAGKKNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKYIKQTENA 607 Query: 799 ELYRFRDRLPEK 810 ++ + Sbjct: 608 NDEAKQELCEKC 619 >UniRef50_Q83FM2 DNA topoisomerase n=2 Tax=Tropheryma whipplei RepID=Q83FM2_TROWT Length = 841 Score = 604 bits (1558), Expect = e-171, Method: Composition-based stats. Identities = 268/824 (32%), Positives = 394/824 (47%), Gaps = 74/824 (8%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESP K ++ +YLG YVV SSVGHIRDLP D Sbjct: 2 KKLVIVESPTKVSSVGRYLGDGYVVMSSVGHIRDLPAPSG----------------LTPD 45 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + + + V+ +++E +Y VL K+KVV EL+ +D + +ATD DREGEAIAWH Sbjct: 46 LKRSAHAQFAVNIENDFEPYYVVLENKKKVVEELQSALNNSDELLIATDGDREGEAIAWH 105 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L +V+ R+VF+EIT+ AI A P ++ + V+AQ+ARR +DR+ GY +SP+ Sbjct: 106 LVQVLKP-TVPVRRLVFHEITREAIAYALQHPRPIDENLVDAQEARRILDRLYGYELSPV 164 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LWKK+ GLSAGRVQS A RL+V+RERE F E+ V A S + + +T Sbjct: 165 LWKKVRPGLSAGRVQSPATRLLVDRERERINFKSAEYQAVTADFQVDS-DVFSASLTLFG 223 Query: 243 DKPF----------------RPVNKEQTQAAVSLLEKARY-SVLEREDKPTTSKPGAPFI 285 ++ ++K T + L+ V + KP + P APFI Sbjct: 224 ERKIATGRDFDNLANLKTDALVLDKNLTDRILEELKSKGALDVEAIDSKPYSRNPYAPFI 283 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 TSTLQQ A+ +LGF K+TM AQ+LYE G+ITYMRTDS LS A++ R + +G+ Sbjct: 284 TSTLQQDAAHKLGFSAKRTMRTAQQLYEKGFITYMRTDSPRLSLQAISAARAQVELLYGR 343 Query: 346 KYLPESPNQYASK-ENSQEAHEAIRPSDVNV-MAESLKD-MEADAQKLYQLIWRQFVACQ 402 ++LP+SP Y +K +N+QEAHEAIRP+ ES++ + D +LY LIWR+ +A Q Sbjct: 344 EFLPDSPRTYGAKAKNAQEAHEAIRPTGEVFERPESIESVLSVDCMRLYDLIWRRTIASQ 403 Query: 403 MTPAKYDSTTLTVGA---GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 M A+ ++ TLT+ A G +L G+ KV L + ++LP + GD + Sbjct: 404 MVSARGETVTLTLSARIPERSIFVLSGTVLHEKGFLKVYEGL-QDLNSKLLPNLQVGDQV 462 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 TLV++ H T PP R++EASLVK LE+ G+GRPSTYA I+STIQ+RGY + NR Sbjct: 463 TLVDVRAVGHTTLPPPRYTEASLVKVLEELGLGRPSTYALILSTIQERGYAHLRNRMLVP 522 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 + + V + LE F L++YDFTA +E+ LD++A L F+ D Sbjct: 523 DWLAFSVVNLLENFFSRLIDYDFTANLEDQLDEIALGSQNRSDWLRKFY----FGDDNLP 578 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL--GCSGYALPPK--------ER 629 E + P G + R G +L G +++P E+ Sbjct: 579 GLKEIISGAKDIDARAINSIPMVGATL--RVGRYGPYLEVGDKRFSIPHDVYPDALTPEK 636 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 +N E + L++ R P D + +P Sbjct: 637 IHELVNQPESPVRELGAHPETGKLVVLKSGRFGPYIEEVSDEKNVRRSSLF--KNMDPE- 693 Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNE------ECKNTRKIL 743 + ++ I ++ G ++ GRFG Y+ C E E L Sbjct: 694 --EVNLDVAVKLLEIPRVIGVNQENGEKVIACNGRFGPYIKCGKETRPLDSEDDILSVTL 751 Query: 744 RNG-----EVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLA 782 + + + ++ G G ++ Sbjct: 752 DEALAILSAPKVRRSRVLMEFPTDDPVTRRAVQIKSGRFGPYVT 795 Score = 47.4 bits (111), Expect = 0.002, Method: Composition-based stats. Identities = 31/168 (18%), Positives = 52/168 (30%), Gaps = 14/168 (8%) Query: 664 KCGTAMDSYLIDPKRKLHVCGNNPTCDG-YEIEEGEFRIKGYDGPIVECEKCGSEMHLKM 722 + G + KR P +I E + + + + G + LK Sbjct: 606 RVGRYGPYLEVGDKRFSIPHDVYPDALTPEKIHELVNQPESPVRELGAHPETGKLVVLKS 665 Query: 723 GRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCE-------KSDAYFVLRDG 775 GRFG Y+ ++E R L V + L ++ + +G Sbjct: 666 GRFGPYIEEVSDEKNVRRSSLFKNMDPEEVNLDVAVKLLEIPRVIGVNQENGEKVIACNG 725 Query: 776 AAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPE 823 G ++ +ETR PL E L E L L+ + Sbjct: 726 RFGPYIKCG-----KETR-PLDSEDDILSVTLDEALAILSAPKVRRSR 767 >UniRef50_B3DUA2 DNA topoisomerase n=13 Tax=Actinobacteridae RepID=B3DUA2_BIFLD Length = 1028 Score = 604 bits (1557), Expect = e-171, Method: Composition-based stats. Identities = 256/748 (34%), Positives = 363/748 (48%), Gaps = 89/748 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M LVIVESP KA I YLG Y V +SVGHIRDL Sbjct: 1 MATKLVIVESPTKAHKIGDYLGKGYTVMASVGHIRDLAQPSQ-----------------V 43 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 A + GVD ++ +Y V K++ VSELK + AD +YLATD DREGEAIA Sbjct: 44 PAADKAKFGKFGVDVNDGFKPYYIVDGDKKRTVSELKSALKNADELYLATDEDREGEAIA 103 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL + + + R+VF+EITKNAI + N +++ + V+AQ+ RR +DR+ GY +S Sbjct: 104 WHLVQTLKPE-VPVKRMVFHEITKNAINASLNNTRDVDGNMVDAQETRRILDRLYGYELS 162 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV-- 238 P+LW+K+ GLSAGRVQSVA RL+VERERE AF +W++ A+ + P + Sbjct: 163 PVLWRKVGPGLSAGRVQSVATRLIVERERERMAFKRAPYWDIVATLSAPDALGERAEFSA 222 Query: 239 -----------------------THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 R +++ A L A ++V+ E KP Sbjct: 223 RMIALGGKRLAGSKDFGADGQLTPDGFAANVRQLDEAGATAVAEALRTADFTVMSMETKP 282 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMV 335 +P PF TSTLQQ A RLG G + M AQ LYE GYITYMRTDS LSQ+A+ Sbjct: 283 YRRRPQPPFTTSTLQQTAGNRLGMGARVVMRAAQSLYENGYITYMRTDSVTLSQEAITAA 342 Query: 336 RGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLYQ 392 R +S +FG K+L P QYA+K +QEAHE IRP+ + D +LY Sbjct: 343 RNAVSYHFGDKFLSAEPKQYATKTAGAQEAHECIRPAGSRFHDPDELASKLPGDQLRLYT 402 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGA------GDFRLKARGRILRFDGWTKVMPALRK--- 443 LIW++ +ACQM A + T+ + A G+ +A G ++ F G+ K RK Sbjct: 403 LIWQRTLACQMADATGSTATVRLSAPAGPTEGEAVFQASGTVIEFPGFMKATGEGRKPKA 462 Query: 444 ---------------------------GDEDRILPAVNKGDALTLVELTPAQHFTKPPAR 476 + + LP ++ G + ++ P H T+PPAR Sbjct: 463 AAPGAGAGSDQAAAAGKTDAKAVRGDASESNTSLPPMSVGQQVEASDIEPDGHETQPPAR 522 Query: 477 FSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE 536 ++EA+LVK LE + IGRPSTYASIISTI DRGYV R + VT LE NF + Sbjct: 523 YTEATLVKTLEAKEIGRPSTYASIISTIMDRGYVYERGRALIPSWLAFSVTKLLETNFPK 582 Query: 537 LMNYDFTAQMENSLDQVANHEAEWKAVLDHFF----SDFTQQLDKAEKDPEEGGMRPNQM 592 L++Y FTA+MEN LD++A+ E + L HF+ + D+A + ++ + ++ Sbjct: 583 LVDYQFTAEMENGLDRIAHGEESGRDWLTHFYFGSGEGAARNADEAHEGLQQQVAQLGEI 642 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVL---EGE 649 +I+ G + +R G +L + + ++ + L V + Sbjct: 643 DARAINTIDIGDGLHVRVGRYGPYLEDMEHLDAEGNPKRASLPDTIAPDELTVAVARDLI 702 Query: 650 DAETNALRAKRRCPKCGTAMDSYLIDPK 677 D + R P G ++ Sbjct: 703 DNHSGGPRELGVDPVSGGTVEVRNGRFG 730 >UniRef50_C6V581 DNA topoisomerase n=2 Tax=Neorickettsia RepID=C6V581_NEORI Length = 827 Score = 600 bits (1546), Expect = e-169, Method: Composition-based stats. Identities = 272/877 (31%), Positives = 425/877 (48%), Gaps = 96/877 (10%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 ++IVESP K K I +YLG D+ V SS GH+R LP Sbjct: 2 NVLIVESPTKGKAIAQYLGKDFRVLSSFGHVRALPNKKG--------------------- 40 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 VD ++E Y++ E VV +L + + A +YLATD DREGEAI+WHL Sbjct: 41 --------SVDVTDSFEMLYKLTDTGETVVPQLIKDVKNATALYLATDPDREGEAISWHL 92 Query: 124 REVIGGDD---ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 EV +D RVVF+EITK A++ A P +++ + V AQ+ R+ +D +VG+ +S Sbjct: 93 VEVFKENDVLPKNVHRVVFHEITKTAVQNAIASPRKIDENLVRAQRLRQALDYLVGFSIS 152 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ SAGRVQSVA+R++ +RE EI F PEE+W V + T G + Q++H Sbjct: 153 PVLWKKLPGSKSAGRVQSVALRILCDRENEIGLFTPEEYWIVSVNMTDGEGLVIPTQLSH 212 Query: 241 QNDKPFRPVN---KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 N + ++ E+ + V + + + V E + K KP PFITST+QQ AST L Sbjct: 213 INGEKLERMSIRGAEEAEKIVEEIRELPFLVEEIKKKELKQKPSPPFITSTMQQTASTVL 272 Query: 298 GFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 GF VKKTM +AQ+LYE G ITYMRTD+T+LS ++V+ +R +I FG++YLP Sbjct: 273 GFSVKKTMSLAQKLYEGIEIGGAIEGLITYMRTDATHLSVESVDAIREFIQKKFGQEYLP 332 Query: 350 ESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAK 407 ESP + K +N+QEAHEAIRP+ + E ++ + D KLY+LIW + +ACQM+ A Sbjct: 333 ESPVLFKKKVKNAQEAHEAIRPTSIFRTPEEIESYLTPDQYKLYRLIWERALACQMSDAI 392 Query: 408 YDSTTLTVGAGDFRLK--ARGRILRFDGWTKVMPALRKGDEDRILPAV----NKGDALTL 461 S + + D + K A +L FDG+ + ++++ + +G + + Sbjct: 393 TSSQNIVFISQDEKFKTSASASLLIFDGFNAAFSHGKNKNKNQGVIDFIKKHKEGAQVKV 452 Query: 462 VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521 ++ P Q+FT+PP R+SEA LVK LE+ GIGRPSTYA+++S +Q+RGY + N+ F E Sbjct: 453 GDVLPTQNFTEPPHRYSEAGLVKHLEELGIGRPSTYATVVSVLQERGYASIVNKSFIPEN 512 Query: 522 MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 G +V++ L F + + Y FTA+ME+ LD+VA+ W V+ F+ F +++ EK Sbjct: 513 RGRLVSEFLVHFFSKYVEYHFTAEMEDRLDKVADGTIFWLDVIQDFWDSFHSNVEEVEKV 572 Query: 582 PEEGGMRPNQ-----------MVLTSIDCPTCGRK-MGIRTASTGVFLGCSGYALPPKER 629 P + V CP C + M + + GVFLGC+ Y + Sbjct: 573 PITEVLAFVNGALAKQKLVSAEVKVGDKCPKCEKGYMHLSVSRYGVFLGCTNYPV----- 627 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 C+ +N ++ + + + + P K +P Sbjct: 628 CRFIVNSYSTDDDTEYPK----QIAQDISLHKGPYG----IYLKYKGKNSSIPKDVDP-- 677 Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVA 749 EE +I + + G E+ + +G +G Y+ + + + E+ Sbjct: 678 -VSIDEEFAHKIASLPKILGKHPADGKEIKMGLGPYGLYLFWNAKY--YNLQFSQMDEMT 734 Query: 750 PPKEDPVPLPELPCEKS---------DAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 K + +KS +RDG G ++ + P+ + Sbjct: 735 LDKAVQFIQSYVIHDKSLLRVLGSYEGEEIQIRDGRYGPYIKCSK------MNVPIPKAE 788 Query: 801 YRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQ 837 + + + K + TK+ Sbjct: 789 SPESLSIETAILLIEKKKNTSKSAKKVATKRKVSTKE 825 >UniRef50_C0W593 DNA topoisomerase n=1 Tax=Actinomyces urogenitalis DSM 15434 RepID=C0W593_9ACTO Length = 931 Score = 599 bits (1545), Expect = e-169, Method: Composition-based stats. Identities = 286/934 (30%), Positives = 410/934 (43%), Gaps = 140/934 (14%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESP K ++I YLGSD+ V++SVGHIRDL Sbjct: 1 MSKKLVIVESPNKVRSIAGYLGSDFDVEASVGHIRDLAQPSE----------------LP 44 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 E+ + VD H ++ +Y V P K+K V++LK+ + AD +YLATD DREGEAIA Sbjct: 45 AAEKKGPYGKFAVDVEHGFKPYYVVNPDKKKTVAQLKKALKDADELYLATDDDREGEAIA 104 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL EV+ R+ F EITK A+ +A EL+ DRV+AQ+ RR +DR+VGY VS Sbjct: 105 WHLLEVLKP-KVPVKRMTFTEITKEAVTRALESTRELDTDRVDAQETRRILDRLVGYEVS 163 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT-----PSGEALA 235 P+LW+K+ GLSAGRVQSVA RLVVERERE AF +W V+A T SG Sbjct: 164 PVLWRKVRAGLSAGRVQSVATRLVVERERERMAFKAAGYWGVEAELGTTGSLEESGRTFT 223 Query: 236 LQV------------THQNDKPFRP---------VNKEQTQAAVSLLEKARYSVLEREDK 274 ++ +D RP +++ +A + + +V E E K Sbjct: 224 ARLATLDGRRVATGRDFGDDGALRPAAVKAHTVHLHEGGARAVADAVMASAPTVTEMETK 283 Query: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNM 334 P +P APF TSTLQQ AS +L ++TM +AQ LYE GYITYMRTDST LS AV Sbjct: 284 PYKRRPAAPFTTSTLQQEASRKLRMNPRETMRVAQGLYENGYITYMRTDSTVLSGQAVAA 343 Query: 335 VRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLY 391 R +++ +G +Y+P P YA+K + +QEAHEAIRP+ + + + +LY Sbjct: 344 ARAQVAELYGAQYVPAKPRLYATKTKGAQEAHEAIRPAGDHFRTPAQVAGALSGAQFRLY 403 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGA------GDFR----------LKARGRILRFDGWT 435 +LIW++ VA QM A + T+ V G R A G ++ F G+ Sbjct: 404 ELIWKRTVASQMADAVGQTATVKVEVPLKEAKGGARDSGVTFRTAGFTASGTVITFRGFL 463 Query: 436 KVMPALRKGDE--------------DRILPAVNKGDALTLVELTPAQHFTKPPARFSEAS 481 R + + LPA+ GD L + H T PP R++EAS Sbjct: 464 AAYEEGRDAERYEAEPGKAGAASAGEVRLPAMEVGDVLDAKVAEASGHETTPPPRYTEAS 523 Query: 482 LVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYD 541 LVK LE+R IGRPSTYA+ +STI DRGYV + + VT LEENF EL++YD Sbjct: 524 LVKALEEREIGRPSTYAATMSTIADRGYVEHRGQALVPTWLAFAVTRLLEENFSELVDYD 583 Query: 542 FTAQMENSLDQVANHEAEWKAVLDHFF-----SDFTQQLDKAEKDPEEGGMRPNQMVLTS 596 FTA ME LD++A E + A L F+ Q + E+ + ++ + Sbjct: 584 FTASMEADLDRIAAGEEDRVAWLTRFYYGDGDGQGAQPGEGPEQGLKAMLDNLGEIDARA 643 Query: 597 IDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVL-NVLEGEDAETNA 655 ++ G + +R G +L +R ++ P+ + E + + Sbjct: 644 VNSIEIGEGITLRVGRYGPYLE-----DEEGKRANVPADVAPDELTVAKAKELFERAADD 698 Query: 656 LRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC- 714 R P G + + + P +E + + + Sbjct: 699 GRELGVDPSTGHVIIAKDGRYGPYVTEVLPEPEGTQEPQDEAAPKKRTSKAKTGPKPRTA 758 Query: 715 -------------------------------GSEMHLKMGRFGKYMA-------CTNEEC 736 G ++ + GR+G Y+ +EE Sbjct: 759 SLFKSMGLSTVTLEQALDLLSLPRVVGQDAEGVDITAQNGRYGPYLKKGTDSRSLESEEQ 818 Query: 737 KNTRKILRNGEVAPPKEDPVPLPELP--------CEKSDAYFVLRDGAAGVFLAANTFPK 788 T + + E+ + S V++DG G + Sbjct: 819 LFTVTLEQALEIFAQPKRRRGQAAPKAPLRELGTDPVSGRPVVIKDGRFGPYFTDG---- 874 Query: 789 SRETRAPLVEELYRFRDRLPEKLRYLADAPQQDP 822 ET L LA+ + P Sbjct: 875 --ETNVTLRRGDDPATVTPERAYELLAEKRAKGP 906 >UniRef50_A4CJB9 DNA topoisomerase n=4 Tax=Bacteria RepID=A4CJB9_9FLAO Length = 820 Score = 599 bits (1544), Expect = e-169, Method: Composition-based stats. Identities = 283/877 (32%), Positives = 415/877 (47%), Gaps = 111/877 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI K+LG D+ V SS GHI DLP+ Sbjct: 1 MAKNLVIVESPAKAKTIEKFLGKDFKVTSSFGHIADLPSRE------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD ++ Y V K+ +V +LK+LA KA+ I+LA+D DREGEAI+ Sbjct: 42 ----------LGVDVDKDFSPKYVVDKEKKALVKKLKELASKAETIWLASDEDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E + D + R+VFN ITK+AI++A P ++N D VNAQQARR +DR+VGY +S Sbjct: 92 WHLAETLKLDADKTRRIVFNSITKSAIQKAIENPRKINYDLVNAQQARRILDRLVGYELS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKKI GLSAGRVQSVAVRL+VERER I+ F P+ ++V A T +G L ++ Sbjct: 152 PVLWKKIKPGLSAGRVQSVAVRLIVERERAIEEFEPQSSFKVAAEFRTENGATLPAKLNE 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 D + + Q ++ L A ++V + KP P APF TSTLQQ AS +L F Sbjct: 212 SFD------TETEAQEFLAGLANASFAVDSLDTKPAKKSPAAPFTTSTLQQEASRKLYFS 265 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 V +TM +AQRLYEAG ITYMRTDS +LS +A+ + I N+G+KY + + + Sbjct: 266 VSRTMQVAQRLYEAGLITYMRTDSVSLSGEAIAAAKEEIVGNYGEKY-SKVRKFQSKSKG 324 Query: 361 SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA--G 418 +QEAHEAIRP+D+ + +++ D +LY+LI + +A QM+ A+ + T + + Sbjct: 325 AQEAHEAIRPTDMGLQRPNVER---DQARLYELIRMRTLASQMSDAQLERTQVKIRNDRD 381 Query: 419 DFRLKARGRILRFDGWTKVM----PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPP 474 D A G +++FDG+ KV ++D +LPA+ +ALT +T Q FT+PP Sbjct: 382 DRLFSANGEVIKFDGFLKVYLEGKDEEDAEEQDGMLPAMQVDEALTNNYITATQRFTRPP 441 Query: 475 ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV---------------------- 512 R++EASLVK+LE+ GIGRPSTYA ISTIQ+RGYV Sbjct: 442 YRYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVEKGTVDGTEREYLQLTLEGGGVKR 501 Query: 513 ---------ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 + + +G IV D L +F +++Y+FTA++E D +A E +W+ V Sbjct: 502 KELSETVGSDKGKLVPTDIGMIVNDFLVSHFANILDYNFTAKVEKDFDDIATGEEDWQDV 561 Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG----- 618 L F+ DF + E++ + P GR++ +R G + Sbjct: 562 LRDFYKDFHPNVLDVEENADRASGE-----RVLGTDPETGRQVAVRLGRFGPMVQIGTAD 616 Query: 619 ---CSGYALPPKERCKTTINLVPENEVLNVLEGE---DAETNALRAKRRCPKCGTAMDSY 672 +A ++ TI E+ + + + R P Sbjct: 617 EEEKPQFASLLPDQSLATITYDEAMELFKLPRKLGTFEGDEVEANVGRYGPYVRYGKKFV 676 Query: 673 LIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACT 732 +D + D E + GRFG ++ Sbjct: 677 SLDEGESVF--------DVDMERAAELIRAKKKQDAPIASYEDKPVTKGKGRFGPFIKWD 728 Query: 733 NE------ECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTF 786 + + E + +L E + + G +T Sbjct: 729 GMFINVPKKYDFDNLSQADIEELIEAKKKKEAEKLVREWPEEDIRIEKGR----WGRHTV 784 Query: 787 PKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPE 823 K R + L +++ L E L+ + Sbjct: 785 IKGR-KKVDLSKDVDPQAVTLEEAQELLSKKKTRKKS 820 >UniRef50_D0GKB0 DNA topoisomerase n=1 Tax=Leptotrichia goodfellowii F0264 RepID=D0GKB0_9FUSO Length = 851 Score = 599 bits (1543), Expect = e-169, Method: Composition-based stats. Identities = 282/803 (35%), Positives = 413/803 (51%), Gaps = 71/803 (8%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K LVIVESP+KAKTI K LG Y V +S GH+ DLP Sbjct: 15 AKKLVIVESPSKAKTIEKILGKGYEVTASYGHVIDLP----------------------- 51 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++G+D +N+E Y+V+ GK +V+ +LK+ ++KA +YLA+D DREGEAIAW Sbjct: 52 ------KTKIGIDVENNFEPKYQVIKGKGEVLKKLKEKSKKASTVYLASDQDREGEAIAW 105 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 H+ I + R+ FNEITK A+ A P ++N + VNAQQARR +DR+VGY +SP Sbjct: 106 HISNYIKQPEK-TKRIEFNEITKTAVNNAIKNPRDINKNLVNAQQARRLLDRIVGYKISP 164 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLWK I + SAGRVQSVA++L+ + E EIK+FVP+++WEV A L + + Sbjct: 165 LLWKTINKNASAGRVQSVALKLICDLEDEIKSFVPQKYWEVGALLENGINLNLVEILKEK 224 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 DK F ++E + L+ ++ E K T +P F TSTLQQ AS+ LG+G Sbjct: 225 VDKIF---DEEVVKKLKKELKGKSLTLDSIEIKKKTQRPPLVFKTSTLQQLASSYLGYGA 281 Query: 302 KKTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN 353 KTM +AQ+LYE G ITYMRTDST +S DA+NM + YI++++GK+Y+ Sbjct: 282 TKTMRIAQQLYEGLSINGENRGLITYMRTDSTRISMDAINMAKDYITNHYGKEYVG-YYV 340 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 SK N Q+AHE IRPSD+N+ E +KD + D KLY+LIW +F+ Q KY+ Sbjct: 341 TKNSKSNVQDAHEGIRPSDINLDPEKIKDSLTNDQYKLYKLIWNRFLVSQFAAMKYEQMQ 400 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 + GD++ + + FDG+ K+ + P + +GD+ + +L + TK Sbjct: 401 INAVNGDYKFRGTINKVIFDGYYKIFK-EEDEIKTADFPELKEGDSYLIKKLNVEEGITK 459 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 PP R+SEA+LVK+LE GIGRPSTYASI+ T++ R YV + +RF+ +G V + LE+ Sbjct: 460 PPTRYSEATLVKKLESEGIGRPSTYASIVETLKTREYVEIIEKRFHPTFLGYEVKNELEK 519 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM 592 NF ++MN FTA ME LD++ +W +L F+ L++ EK+ E+ R + Sbjct: 520 NFEDIMNVKFTAIMEEDLDKIEEGNVQWVELLKKFYDSLEIHLEQYEKEIEKLKDRRIES 579 Query: 593 VLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 + S D G M ++T G +L S K K + E + E+ E Sbjct: 580 DVLSSD----GSPMLLKTGRFGKYLV-SETNPEEKITIKGIAVEAEQIEAGKIFIKEEVE 634 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 K G D + + KR + G E E + + PI + Sbjct: 635 KLQANKK------GIPTDFFTENDKRYMLKKGRFGEYLESEDYENDEKRMSLPLPIKQKY 688 Query: 713 KCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL 772 K G ++ G +I ++ + CEK F + Sbjct: 689 KKG-TLNEVNG---------------VLQINEEITAIINEDKKIIEEAGVCEKCGRPFEI 732 Query: 773 RDGAAGVFLAANTFPKSRETRAP 795 + G G FLA +P+ + +A Sbjct: 733 KMGRFGKFLACTGYPECKNIKAI 755 >UniRef50_B0RAE2 DNA topoisomerase n=17 Tax=Bacteria RepID=B0RAE2_CLAMS Length = 1012 Score = 592 bits (1527), Expect = e-167, Method: Composition-based stats. Identities = 257/714 (35%), Positives = 354/714 (49%), Gaps = 61/714 (8%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K LVIVESPAKAKTI +YLGS Y V++SVGHIRDL + + T Sbjct: 47 KKLVIVESPAKAKTIAQYLGSGYEVQASVGHIRDLIEPKNLPPELKKGTLG--------- 97 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + VD + +E +Y V K+K V++LK+ + AD ++LATD DREGEAIAWH Sbjct: 98 -------KFSVDVENGFEPYYVVSDQKKKTVADLKRALKDADELFLATDEDREGEAIAWH 150 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L +V+ R+VF+EITK AI +A + +++ V+AQ+ RR +DR+ GY VSP+ Sbjct: 151 LLQVLKP-KVPVKRMVFHEITKEAIERARDSTRDIDTALVDAQETRRILDRLYGYEVSPV 209 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST---------------- 226 LW+K+ GLSAGRVQS A RLVV+RERE AFV +W++ AS Sbjct: 210 LWRKVGPGLSAGRVQSAATRLVVDRERERLAFVTASYWDLTASLSPLEQELPFDARLVRI 269 Query: 227 ---TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 +G + +ND + + A V E KP T +P AP Sbjct: 270 DGARIATGRDFDDKGALKNDSRPLDASSAEALAEALRDPSVPLKVQSVESKPYTRRPAAP 329 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNF 343 F TSTLQQ A+ +L F ++TM +AQ LYE GYITYMRTDS +LSQ A+N R ++ + Sbjct: 330 FTTSTLQQEAARKLRFSARQTMSVAQSLYENGYITYMRTDSPSLSQQAINAARKQAAELY 389 Query: 344 GKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLYQLIWRQFVA 400 G + +P+ P YA K +N+QEAHEA+RP+ + + KLY LIW++ +A Sbjct: 390 GPETVPDKPRLYAGKSKNAQEAHEAVRPAGETFRTPQQLASTLRGNDHKLYDLIWKRTIA 449 Query: 401 CQMTPAKYDSTTLTVGAGD------FRLKARGRILRFDGWTKVMPALRKGDE-------D 447 QM AK + ++ + AG A G ++ F G+ R + + Sbjct: 450 SQMADAKGSTASVVIAAGPTSAGEVAEFAASGTVITFRGFLAAYEESRDEERHGAAEPRE 509 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 LP + KG L LV++ H T PP R++EASLVK LE+ GIGRPSTYA+IISTI DR Sbjct: 510 AKLPDLKKGQDLRLVDVDAKGHETSPPPRYTEASLVKTLEELGIGRPSTYAAIISTIVDR 569 Query: 508 GYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 GYV + V LEE F EL+ YDFTA ME+ LD++A AE L F Sbjct: 570 GYVTPRGTALVPNWIAFSVVRLLEEFFTELVQYDFTAGMEDDLDRIAEGAAERVDWLKGF 629 Query: 568 FSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFL---GCSGYAL 624 + + A K ++ I+ + +R G +L A Sbjct: 630 Y-----YGNDAHKGLRPTIDNLGEIDAKEINSLRIADDITLRIGKYGPYLEVHEEGAAAD 684 Query: 625 PPKERCKTTINLVPENEVLNVLEGEDAET-NALRAKRRCPKCGTAMDSYLIDPK 677 R +L P+ R P G + + Sbjct: 685 ATPRRVNLPEDLAPDELTAAKARELIDAPVVTDRVIGINPDNGKQVVAKDGRYG 738 >UniRef50_A6DJX4 DNA topoisomerase n=2 Tax=Bacteria RepID=A6DJX4_9BACT Length = 897 Score = 591 bits (1523), Expect = e-167, Method: Composition-based stats. Identities = 259/601 (43%), Positives = 352/601 (58%), Gaps = 55/601 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K LVIVESPAKAKTI K LG D+ VK+S GH+RDLP Sbjct: 3 KKNLVIVESPAKAKTIEKILGKDFEVKASFGHVRDLPQR--------------------- 41 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++GVDP +++E Y+V K+KV++ELK A+ ++IYLA D DREGEAIAW Sbjct: 42 --------KLGVDPDNDFEPEYQVSADKKKVIAELKSSAKNCENIYLAPDPDREGEAIAW 93 Query: 122 HLREVIGGDDA-RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 HL E++ + RV FNEITK+AI+ AF+K ++++ RV+AQQARR +DR+VGY VS Sbjct: 94 HLYEILKKQSKAEFKRVTFNEITKSAIKSAFDKAHDVDMHRVDAQQARRILDRLVGYKVS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT--PSGEALALQV 238 PLLWK SAGRVQ+VA+RL+ ERE+ I+AF PEE+W + A ++ ++ Sbjct: 154 PLLWK--RNARSAGRVQTVALRLICEREKAIRAFTPEEYWSLQAELKNQAADAQSFISKL 211 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 + K N+E + V LE +++ V + E K +P PFITSTLQQAAS+ L Sbjct: 212 DKIDGKKPHIPNEETSSKIVGELEGSQFRVKDIESKDRKKRPAPPFITSTLQQAASSNLR 271 Query: 299 FGVKKTMMMAQRLYE---------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 F +TM +AQ+LYE AG ITYMRTDS ++++A N +++ +G ++ P Sbjct: 272 FSPSRTMSLAQKLYEGRDLGSEGTAGLITYMRTDSVAIAKEAQNAAIDFVNHIYGSEFSP 331 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKY 408 + PN Y SK ++Q HEAIRP+DV + + + D KLY LIW++FVA QM PA Y Sbjct: 332 DKPNFYKSKNSAQGGHEAIRPTDVTRTPKKMAPYLNDDELKLYTLIWKRFVASQMVPALY 391 Query: 409 DSTTLTV------GAGDFRLKARGRILRFDGWTKVMPALRK-----GDEDRILPAVNKGD 457 ++T + ++ K G +L FDG+ KV +D ILP + +G+ Sbjct: 392 RQDSITFLPENIGMSHEYLFKITGSVLIFDGFMKVYNFSDDGSQDGESKDVILPQLKEGE 451 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L++L P QHFT+PP RFSEA+LVKELE G+GRPSTYASII TIQDR YV + R Sbjct: 452 ICDLLQLIPKQHFTEPPPRFSEATLVKELEANGVGRPSTYASIIRTIQDREYVFKDKGRL 511 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 G D L L FTA ME LD+V + + EW +L F+S F L+ Sbjct: 512 NPSDKGMESCDFLITTLPSLFEVTFTAHMEELLDKVEHGDLEWTKMLGDFYSGFKDWLED 571 Query: 578 A 578 A Sbjct: 572 A 572 Score = 58.2 bits (139), Expect = 1e-06, Method: Composition-based stats. Identities = 15/62 (24%), Positives = 23/62 (37%) Query: 730 ACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKS 789 C + L +A K ++ C K D+ V + G G F A + FPK Sbjct: 824 KCVGRYKEKIPAELFPEGLADAKSGGEEKTDVKCPKCDSPIVKKVGKRGPFYACSGFPKC 883 Query: 790 RE 791 + Sbjct: 884 KN 885 Score = 44.7 bits (104), Expect = 0.016, Method: Composition-based stats. Identities = 9/64 (14%), Positives = 20/64 (31%), Gaps = 1/64 (1%) Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNP 687 ++C E+ + + +CPKC + + + + + C P Sbjct: 823 KKCVGRYKEKIPAELFPEGLADAKSGGEEKTDVKCPKCDSPIV-KKVGKRGPFYACSGFP 881 Query: 688 TCDG 691 C Sbjct: 882 KCKN 885 Score = 44.7 bits (104), Expect = 0.017, Method: Composition-based stats. Identities = 17/111 (15%), Positives = 34/111 (30%), Gaps = 14/111 (12%) Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA--VLDHFFSDFTQQLD 576 K G + D +++F E ++ +F A + L + +++ Sbjct: 787 PTKRGRMTYD--DKSFYESLSSNF-AN---------KGSLTPRQSAALKKCVGRYKEKIP 834 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPK 627 + T + CP C + + G F CSG+ Sbjct: 835 AELFPEGLADAKSGGEEKTDVKCPKCDSPIVKKVGKRGPFYACSGFPKCKN 885 >UniRef50_D1N8U4 DNA topoisomerase n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N8U4_9BACT Length = 841 Score = 589 bits (1518), Expect = e-166, Method: Composition-based stats. Identities = 255/639 (39%), Positives = 346/639 (54%), Gaps = 52/639 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP KA+TI K LG DY + +S+GHIRDLP Sbjct: 1 MSK-LLIVESPTKARTIGKMLGKDYDIFASMGHIRDLPERD------------------- 40 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD +++ Y + VV ELK A+KAD IYLA D DREGEAIA Sbjct: 41 ----------LGVDIANHFAPQYVDTARSKSVVKELKSAAKKADEIYLAPDPDREGEAIA 90 Query: 121 WHLREVIGGDDA-RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WHL EV+ + RV F+EIT++AI +A + GE+N++ V+AQQARR +DR+VGY V Sbjct: 91 WHLAEVLNKSTKAPFYRVTFHEITRSAIERAMQEKGEINLNLVDAQQARRVLDRIVGYQV 150 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT 239 SPLLW +I +G SAGRVQS A+RLVVERER I AFVPEE+W T SGE ++ Sbjct: 151 SPLLWSRIEKGSSAGRVQSAALRLVVERERAINAFVPEEYWVFSVVFRTESGEEFTSRLF 210 Query: 240 HQNDKPFRPVNKEQTQAAVSLLEKARY-SVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 N K F+ N E + + ++ +V APF TSTLQQAA+ L Sbjct: 211 KINGKDFKVPNAEAAEQLIRAIQGGSAPAVASVTTAERKRYAQAPFTTSTLQQAANVSLH 270 Query: 299 FGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 + TM AQ+LYE G ITYMRTDS ++++A +I +G Y+P Sbjct: 271 YSATNTMRYAQQLYEGMDIGEGGAVGLITYMRTDSVTIAREAQQAAAEFIRRTYGDAYVP 330 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKY 408 N Y +K +QEAHEAIRP+DV E + ++ KLY LIWR+FVA QMTPA Sbjct: 331 AKFNYYKNKAAAQEAHEAIRPTDVRRTPEQMAAYLDPQQLKLYTLIWRRFVASQMTPAVV 390 Query: 409 DSTTLTVGA-----GDFRLKARGRILRFDGWTKVMPALRKGDEDRI----LPAVNKGDAL 459 + TT+ VG + + + F G +KV + K ++ L ++ + D L Sbjct: 391 NLTTVDVGVDGSDGNGYTFRTTATVPVFPGHSKVYEDVAKRKDETQEAAVLGSLRERDPL 450 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 L + Q FT+PP R++EASL+KELE+ GIGRPSTYA+I+ TIQDR YV E + Sbjct: 451 ELRKFDKEQKFTEPPPRYTEASLIKELEENGIGRPSTYATILRTIQDRNYVNREQGKLIP 510 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 ++G V D L E L + FTAQME LD++ + W +++ F+S F ++ A+ Sbjct: 511 SELGFSVNDFLVERLPALFDIGFTAQMEKELDEIEEGKVGWTQMMEDFYSKFAPWVEDAK 570 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCG-RKMGIRTASTGVFL 617 ++ + K+G RT G F Sbjct: 571 NSDAPPAADAEALLKLLENVTFEAPGKVGRRTYDDGKFF 609 >UniRef50_C9RSM0 DNA topoisomerase n=49 Tax=Bacilli RepID=C9RSM0_GEOSY Length = 697 Score = 587 bits (1512), Expect = e-166, Method: Composition-based stats. Identities = 178/703 (25%), Positives = 299/703 (42%), Gaps = 86/703 (12%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ A+ I + LG Y+V ++GH+ +L +K Sbjct: 2 KSLVLAEKPSVARDIARVLGCKETHKPYFEGPRYIVTWALGHLVELKMPEDYDRKYETW- 60 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADH--IYLA 109 R+ P + +V+ +++LA++ D + +A Sbjct: 61 ------------------RLEDLPIIPKKMGLKVIRQTSHQFRAIERLAKRPDVKDVIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQA 167 TD REGE +A + E+IG R+ + T AIR F KPG + Sbjct: 103 TDAGREGELVARWILEMIGW-TKPIWRLWISSQTDRAIRDGFRQLKPGAQFDRLYQSAVC 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D ++G VS L K LSAGRVQ+ + +++EREREI++FVP +W + A Sbjct: 162 RAEADWLIGLNVSRALTTKYNDPLSAGRVQTPTLAMIIEREREIQSFVPVPYWTIRAKIG 221 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + + + R ++++ + ++ L+ V+ + K + P+ + Sbjct: 222 S-------ITAVWERHGGHRLFDQDEAKQLLARLDGQPARVVSVKRKRKSEPAPLPYDLT 274 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYI---SDNF 343 LQ+ A+ R GF KKT+ + QRLYE +TY RTDS L D + + + Sbjct: 275 ELQRDANKRFGFSAKKTLSVLQRLYEQHKLVTYPRTDSRYLPSDMEATMTERLLAMKSGY 334 Query: 344 GKKYLP------ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 P + ++ H AI P+D + +L + D +KLY LI R+ Sbjct: 335 EDVIAPLLAKGKAKAAKRVFNDDKVTDHHAIVPTDERL---NLSRLSTDERKLYDLIARR 391 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 F+A P + ++TT G A+ + G+ V+ + D L + +G Sbjct: 392 FLALFFPPYESETTTAVFDIGGEMFVAKETAVVNFGFKAVLG-KEETDAKPTLSHLAEGQ 450 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L V+L Q FT+PPAR+SEA L+ ++EK G+G P+T A II + + V ++ RF Sbjct: 451 TLPSVQLEREQSFTEPPARYSEADLLAQMEKYGLGTPATRADIIERLVETEVVERKDGRF 510 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 Y K G+ + + + E EL + + TA+ E L+ +A + + L + Q + + Sbjct: 511 YPTKKGKQLIELVNE---ELKSPELTARWERELEAIARGKGNPQQFLANIRRQTQQLVAE 567 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV 637 ++ + LT++ CP CG + R G L CS A C+ Sbjct: 568 IKQSEQVYKAP----NLTNLTCPECGALLKERKTKDGRMLVCSNLA------CRYRRRRD 617 Query: 638 PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 P+ + RRCP+C M+ + Sbjct: 618 PK-----------------LSNRRCPQCHRRMEMHEGKAGMYF 643 Score = 49.7 bits (117), Expect = 5e-04, Method: Composition-based stats. Identities = 13/80 (16%), Positives = 30/80 (37%), Gaps = 12/80 (15%) Query: 704 YDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPC 763 + + C +CG+ + + + G+ + C+N C+ R+ L C Sbjct: 578 PNLTNLTCPECGALLKERKTKDGRMLVCSNLACRYRRRRDPK------------LSNRRC 625 Query: 764 EKSDAYFVLRDGAAGVFLAA 783 + + +G AG++ Sbjct: 626 PQCHRRMEMHEGKAGMYFQC 645 >UniRef50_A0LAP8 DNA topoisomerase n=13 Tax=cellular organisms RepID=A0LAP8_MAGSM Length = 744 Score = 587 bits (1512), Expect = e-166, Method: Composition-based stats. Identities = 165/773 (21%), Positives = 279/773 (36%), Gaps = 120/773 (15%) Query: 4 ALVIVESPAKAKTINKYLG-----SDYV------VKSSVGHIRDLPTSGSAAKKSADSTS 52 L + E P++ + I + LG YV V +GH+ ++ + Sbjct: 2 ILYLCEKPSQGRDIGRVLGATSRHEGYVAGAGVCVTWCIGHLMEMVAPDGYRPEWKSW-- 59 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 R+ P + E+ K ++ L + + LATD Sbjct: 60 -----------------RLDTLPIIPQQWQLELTARGRKQFKVIQGLLKGVTEVVLATDA 102 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRF 170 DREGE I + E + SR+ + + +IR+A PGE A R Sbjct: 103 DREGETIGREVLERC-QYRGKISRLWLSALDDASIRKALGNLLPGEQTEPLYQAGLGRSR 161 Query: 171 MDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 D +VG ++ +G LS GRVQ+ ++LVV+R+R I+ F P +++E+ A Sbjct: 162 ADWMVGMNLTRAYTLLGRQGGYAGVLSVGRVQTPTLKLVVDRDRLIENFKPVDYFEIFAL 221 Query: 226 TTTPSGEALALQVTHQN--DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 SG +A V D +++ + + ++ ++ + E K P P Sbjct: 222 HRVHSGTFIAKWVPPPKPCDAEGHCLDRTLAETVIHKVQGHSGTITKAETKRVKEPPPLP 281 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDN 342 STLQQ AS R G G K+T+ +AQ LYE +TY RTD L + + Sbjct: 282 LELSTLQQEASRRWGMGAKQTLEIAQSLYEKHKAVTYPRTDCRYLPSNQFKEAPAVLQGL 341 Query: 343 FGK--------KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 + A + AH AI P+ + ++ + + LY LI Sbjct: 342 TTNDASLTPLVEGADAQLRSKAWNDKKITAHHAIIPTAAKI---NIDALSREEALLYDLI 398 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM----PALRKGDEDRIL 450 R ++A P +YD T + A GR+ GW +V+ ++++ L Sbjct: 399 RRHYLAQFYPPFEYDRTVIDTQVAMETFHATGRVELIPGWKRVLAANQEKKEGDEDEQTL 458 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGR 493 P V G+A T+ Q TKPP R++E +L++ + E GIG Sbjct: 459 PVVRSGEAATIEGAELKQKQTKPPNRYTEGTLIQAMKSVGKLVEDARLRKILRETSGIGT 518 Query: 494 PSTYASIISTIQDRGYVRVENRR-FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 +T A+I+ T+ R + + ++ + G ++ D L + + TA E +LD Sbjct: 519 EATRAAILETLIKRNLLAKQGKKSLVSMPAGRLLVDALPH---SVTDPATTAVWEQTLDD 575 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID-------------- 598 +A+ + L + + + + G + ++ Sbjct: 576 IAHGGGSLETFLAKSELWLNKLIHNVHQRQQLGLNPFRGLPPSTSHTDPAQPTPRRQRRS 635 Query: 599 -------------CPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 CP CG M R + G F C + C T P + Sbjct: 636 KAEVTPTPNAAPLCPQCGGPMLQRKSPQGAFWSC-----AEQATCTGTRPGSPLAAHSPL 690 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDS-----YLIDPKRKLHVCGNNPTCDGYE 693 ++ CPKC A + + C P C + Sbjct: 691 MQ------PNPERGPLCPKCQQAPLVQRTAYRGKNSGQPFWGCQRYPQCRYTQ 737 Score = 72.8 bits (177), Expect = 6e-11, Method: Composition-based stats. Identities = 24/107 (22%), Positives = 33/107 (30%), Gaps = 8/107 (7%) Query: 700 RIKGYDGPIVECEKCGSEMHLKMGRFGKYMACT-NEECKNTRKILRNGEVAPPKEDPVPL 758 + C +CG M + G + +C C TR + P P P Sbjct: 638 EVTPTPNAAPLCPQCGGPMLQRKSPQGAFWSCAEQATCTGTRPGSPLAAHS-PLMQPNPE 696 Query: 759 PELPCEKS-DAYFVLRDGAAG-----VFLAANTFPKSRETRAPLVEE 799 C K A V R G F +P+ R T+A E Sbjct: 697 RGPLCPKCQQAPLVQRTAYRGKNSGQPFWGCQRYPQCRYTQASQTTE 743 Score = 50.9 bits (120), Expect = 2e-04, Method: Composition-based stats. Identities = 16/103 (15%), Positives = 27/103 (26%), Gaps = 2/103 (1%) Query: 740 RKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEE 799 + R + + P P C + + R G F + TR Sbjct: 626 QPTPRRQRRSKAEVTPTPNAAPLCPQCGGPMLQRKSPQGAFWSCAEQATCTGTRPGSPLA 685 Query: 800 LY-RFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVS 841 + PE+ QQ P +T R + + Sbjct: 686 AHSPLMQPNPERGPLCPKC-QQAPLVQRTAYRGKNSGQPFWGC 727 >UniRef50_C6CZS8 DNA topoisomerase n=5 Tax=cellular organisms RepID=C6CZS8_PAESJ Length = 719 Score = 584 bits (1505), Expect = e-165, Method: Composition-based stats. Identities = 172/754 (22%), Positives = 300/754 (39%), Gaps = 108/754 (14%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ AK I + LG DYVV ++GH+ L K Sbjct: 2 KSLVLAEKPSVAKEIARVLGCSSKNKSYMEGPDYVVTWALGHLVTLAEPEDYDPKYKTWN 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLA 109 + P + + +V+ + QL ++ D + +A Sbjct: 62 -------------------LEDLPLLPGKMNLKVMRETSHQYKAVAQLCKRPDIGELIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQA 167 TD REGE +A + E++ + R+ + T AI+ F KPG+ + + Sbjct: 103 TDAGREGELVARWIMELVHWR-KPFKRLWISSQTDKAIKDGFKALKPGQQYNNLYASAVC 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D ++G V+ L K L+AGRVQ+ + +++RE+EI F + +W V A Sbjct: 162 RAEADWLIGLNVTRALTVKYNAQLAAGRVQTPTLGALIDREKEINQFQSQPYWTVSAELG 221 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 A ++ R ++ + +A ++ L+ V + + F + Sbjct: 222 -----AFQALWRQNDNHDGRVWDRSEAEAVIARLQGKSAKVDKLRTTQKSEPHPQAFDLT 276 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 LQ+ A+ RLGF K T + Q+LYE +TY RTDS LS D V ++G + Sbjct: 277 ELQREANKRLGFSAKMTSNVLQKLYEQHKLVTYPRTDSRYLSSDIVPTLKGRLESVAVGP 336 Query: 347 YLPESPN---------QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 Y P + + ++ H AI P+D V +L + D +KLY LI R+ Sbjct: 337 YAPLARKLLRGQLTVTKRFVDDSKVSDHHAIIPTDEYV---NLSALSNDERKLYDLIVRR 393 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPA-------LRKGDED--- 447 F+A P YD T++ + G +L A+G++ + GW ++ +E+ Sbjct: 394 FIALFYPPYTYDETSVVLTVGQDKLYAKGKVQKDIGWKELYGGSDARFTADEDDEEENGR 453 Query: 448 --------RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYAS 499 ++LP + +G A+ + + + T PPAR++EASL+ ++EK G+G P+T A Sbjct: 454 GEDKSTPEQLLPELVQGQAVQVKQSRLKELRTLPPARYTEASLLSKMEKHGLGTPATRAD 513 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 II + + R G+ + + + + EL + + TA+ E L+ +A+ + + Sbjct: 514 IIEKLLSTDTIERTQNRLVPTSKGKQLIELVVD---ELRSPELTAKWERELELIAHGQGD 570 Query: 560 WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC 619 K + + + + LT CP CG+ + G L C Sbjct: 571 AKRFMAGIREQANKWVTAV----KNETKEYKPHNLTHSRCPECGKLLMEVKGKRGKSLVC 626 Query: 620 SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRK 679 S C P + +RCP+C M+ + + Sbjct: 627 S------DRECSYRRQAEPA-----------------LSNKRCPQCHKKMEIHNGKAGK- 662 Query: 680 LHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEK 713 C + E +G + +K Sbjct: 663 ------YAQCRPCNVIEMLGDKQGGRVNKHQQKK 690 Score = 55.5 bits (132), Expect = 9e-06, Method: Composition-based stats. Identities = 16/91 (17%), Positives = 29/91 (31%), Gaps = 12/91 (13%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDP 755 K ++ C +CG + G+ GK + C++ EC R+ Sbjct: 591 NETKEYKPHNLTHSRCPECGKLLMEVKGKRGKSLVCSDRECSYRRQAEP----------- 639 Query: 756 VPLPELPCEKSDAYFVLRDGAAGVFLAANTF 786 L C + + +G AG + Sbjct: 640 -ALSNKRCPQCHKKMEIHNGKAGKYAQCRPC 669 >UniRef50_A8F3N1 DNA topoisomerase n=2 Tax=Thermotogaceae RepID=A8F3N1_THELT Length = 722 Score = 581 bits (1498), Expect = e-164, Method: Composition-based stats. Identities = 250/799 (31%), Positives = 402/799 (50%), Gaps = 96/799 (12%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M ++IVESPAKAKTI + L +Y V SS GH+RDLP Sbjct: 1 MANKIIIVESPAKAKTIKEILKGEYDVLSSKGHVRDLPEKEF------------------ 42 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 GV+ ++E ++++ GKEK+V ELK+ A+ + L +D+DREGEAIA Sbjct: 43 -----------GVNIEKDFEPTFKIIYGKEKIVQELKKKAKN-KQVLLGSDMDREGEAIA 90 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +++G + + +R++FNEIT AI+ A +P +++++V+AQ ARR +DR+VGY +S Sbjct: 91 WHLADILGVANEK-NRIIFNEITPQAIKNAVKEPRNIDMNKVHAQLARRILDRIVGYKIS 149 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWK + SAGRVQS A+++V ERE + F P++FW+V + L +TH Sbjct: 150 PLLWKMLKTSSSAGRVQSAALKIVCEREIQRHKFQPKKFWKVQGYIGS-----LKFYLTH 204 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + K ++ A V++ + + K +PFITSTLQQ A+ +LGF Sbjct: 205 IDGKKIDMQQIDEKLAKEIEKNVKVLKVIQIKTRKIQKKAPSPFITSTLQQEAANKLGFS 264 Query: 301 VKKTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 VKKTM +AQ+LYE +ITYMRTDST +S+ A +I+D FGK YL + Sbjct: 265 VKKTMQIAQQLYEGIDTPKGHRAFITYMRTDSTRVSEIAKQKAIEFITDKFGKNYLGKKV 324 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTPAKYDST 411 +K+N Q+AHEAIRP ++++ + ++ D+ D +LY+LIW +F+A QM A Y+ T Sbjct: 325 RTEKAKQNVQDAHEAIRPVNIDLTPDQVEGDLGKDQYRLYKLIWERFMASQMADAIYEET 384 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 T+ + + +++ FDG+ ++ + +++ +P+ G+ + + + + T Sbjct: 385 TIQFQSDRYTFESKIERRIFDGFEIILK--KDKEQEITIPS---GE-IRISKWQIEEDET 438 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPPAR++EAS+V+ LE RGIGRPSTYA+IIST+ +R YV + + MG +V LE Sbjct: 439 KPPARYTEASMVRALEIRGIGRPSTYATIISTLLERKYVIKSSNQLIPTVMGFVVNHYLE 498 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 + F E+++ FTA+ME +LD++ + ++K +L F++DF++ LD+A++ M N Sbjct: 499 KKFPEIVDLQFTAKMEEALDKIEQGQKDYKELLRDFYNDFSKYLDEAQQKWLSIDMNTNL 558 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 C K ++ G++L C C T +L E + Sbjct: 559 -------ECDCKSKYKLKVGRYGLYLLCEN--------CSKTTSLALETPAVFYENTMYF 603 Query: 652 ETNALRAKR-RCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVE 710 + CP CG ++ N C F + Sbjct: 604 THQEKESIETVCPVCGGKLEQMSGRYG-------NYIKCQNCGKTYTGFA-------RGK 649 Query: 711 CEKCGSEMHLKMGRFGK-YMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C KC + + K+ + + + CT++ C + C + Sbjct: 650 CPKCSAVVEKKISKNKRIFFKCTSDNCDFISWLEP--------------SNETCPECSQR 695 Query: 770 FVLRDGAAGVFLAANTFPK 788 + + L K Sbjct: 696 LYYKKYRSKEVLYCQNCKK 714 Score = 45.5 bits (106), Expect = 0.009, Method: Composition-based stats. Identities = 19/144 (13%), Positives = 38/144 (26%), Gaps = 28/144 (19%) Query: 713 KCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELP----CEKSDA 768 C S+ LK+GR+G Y+ C N + + + C Sbjct: 561 DCKSKYKLKVGRYGLYLLCENCSKTTSLALETPAVFYENTMYFTHQEKESIETVCPVCGG 620 Query: 769 YFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTM 828 G G ++ K Y A + P+ + + Sbjct: 621 KLEQMSGRYGNYIKCQNCGK-----------------------TYTGFARGKCPKCSAVV 657 Query: 829 -VRFSRKTKQQYVSSEKDGKATGW 851 + S+ + + + + W Sbjct: 658 EKKISKNKRIFFKCTSDNCDFISW 681 >UniRef50_A4JTK7 DNA topoisomerase n=2 Tax=Burkholderiales RepID=A4JTK7_BURVG Length = 893 Score = 578 bits (1491), Expect = e-163, Method: Composition-based stats. Identities = 192/902 (21%), Positives = 317/902 (35%), Gaps = 157/902 (17%) Query: 1 MGKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSAD 49 MGK L+I E P+ AK I LG D ++ S+ GH+ + Sbjct: 1 MGKTLIIAEKPSVAKDIALALGGFGRVDNWLESPDAIISSAQGHLVE------------- 47 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEK--VVSELKQLA--EKADH 105 + P V+ G + + ++LK+L + D Sbjct: 48 ---------VFSTLMDTSGKDLQSLPVIPPSFDLRVIDGANRPQLFAQLKRLMSRQDVDA 98 Query: 106 IYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVN 163 + A D REGE I + ++ G R+ F +T AIR++F+ KPG + Sbjct: 99 VVNACDAGREGELIFRLIYKLAGC-TKPMKRMWFRSMTPEAIRESFHSMKPGADFDGLSD 157 Query: 164 AQQARRFMDRVVGYMVSPLLWKKIAR------GLSAGRVQSVAVRLVVEREREIKAFVPE 217 A R D +VG S + + R S GRVQ+ LV +RE I+ F + Sbjct: 158 AAFCRTEGDYLVGINGSRGVTRLYERQTASVENRSVGRVQTPTGALVYDREMAIRTFRAK 217 Query: 218 EFWEVDASTTTPSGEALALQVT-------------------HQNDKPFRPVNKEQTQAAV 258 ++WEV +G + ++ R K++ A V Sbjct: 218 DYWEVHGHFGVAAGNYVGKWFDPNFKASGEQQELGEGGGSGKSDETANRFFEKDRADAIV 277 Query: 259 SLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT 318 + + + E KPT + ++LQ+ A+ +LG K+T+ +AQ LYE +T Sbjct: 278 AKCSGTNPTDVREESKPTAKGSPRLYDLTSLQREANRKLGLSSKRTLDIAQALYEKHKVT 337 Query: 319 -YMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPN----------QYASKENSQEAHEA 367 Y RTDS+ L +D V + I G Y P + + H A Sbjct: 338 TYPRTDSSFLPEDYVAKAQSTIESLVGTTYEPHAKRVIDGGWVKPDKKIFDNGKISDHFA 397 Query: 368 IRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGR 427 I P+ + + + + K+Y +I R+F+A A+Y TT K+ GR Sbjct: 398 IIPTG-----KRPEGLTPEEGKVYDMIVRRFLAVFHPAAQYQVTTRITVVAGEHFKSSGR 452 Query: 428 ILRFDGWTKVMPALRKGDEDRI--LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKE 485 +L +GW V A ++ + L G+A+T V + TKPP R++E +L+ Sbjct: 453 VLISEGWMAVYGADVDDEDKKTPALVKYEAGEAVTTVRIELKTLKTKPPLRYTEDTLLAA 512 Query: 486 LE----------------KRGIGRPSTYASIISTIQ---------DRGYVRVENRRFYAE 520 +E +RG+G P+T A+II + Y++ + + Sbjct: 513 MESAGKFVDDDELADAMKERGLGTPATRAAIIEGLLADKDGKGNPKEPYLKRDGKSLVPT 572 Query: 521 KMGEIVTDRLEENFRE-LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 + + L N E L + T + E+ L + E A + Q +D Sbjct: 573 PKLISLIEFLRNNGIELLASPKLTGEWEHKLRLIERGEYRRDAFNNEIGDLTRQIIDAIR 632 Query: 580 KDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC-------------------- 619 K + CP CG ++ I + C Sbjct: 633 K-----KAAEVVVKKLDAKCPQCGGEIAIGARTFDCESACGFRLWKEIAGRQLKPSEANT 687 Query: 620 ----------SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAM 669 + + K++ + L E++V + T+A CP C + Sbjct: 688 LLTTRVVMNLNNFISNSKKKFTACLRLNDEHKVEFFFDETVNTTDASGNPVHCPVCEK-L 746 Query: 670 DSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYM 729 + C + C + + C KC S+M+ G+ G + Sbjct: 747 MRRISGANGHFWSCTDRENCKTTLDDSAGNPVPK--VAAQPCPKCSSDMNRVRGKKGYFW 804 Query: 730 ACTNEE-CKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYF--VLRDGAAGVFLAANTF 786 +CT+ E CKNT V P + C A R G F + F Sbjct: 805 SCTDREGCKNTMDDKDGAPVTRPD-------PIACPDCGAQMFRRERRDKKGYFWGCSAF 857 Query: 787 PK 788 K Sbjct: 858 KK 859 >UniRef50_C7NA27 DNA topoisomerase n=20 Tax=Fusobacteriaceae RepID=C7NA27_LEPBD Length = 800 Score = 577 bits (1487), Expect = e-163, Method: Composition-based stats. Identities = 283/782 (36%), Positives = 414/782 (52%), Gaps = 78/782 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESP+KAKTI K LG +Y V +S GH+ DLP Sbjct: 1 MARKLVIVESPSKAKTIEKILGRNYEVVASYGHVIDLP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 ++G+D +N+E Y+V+ GK +V+ +LK+ A+ A+ +YLA+D DREGEAIA Sbjct: 39 -------KTKIGIDVENNFEPQYKVIKGKGEVLKKLKEKAKSANAVYLASDQDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WH+ I D R+ FNEITK A+ A P ++N + VNAQQARR +DR+VGY +S Sbjct: 92 WHISNYIKQPDK-VKRIEFNEITKTAVNNAIKNPRDINDNLVNAQQARRLLDRIVGYKIS 150 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PLLWK I R SAGRVQSVA++L+ + E EI AFVP+++WEV A L Sbjct: 151 PLLWKIINRNASAGRVQSVALKLICDLEDEINAFVPQKYWEVSALIEKDINLNLVKIANE 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + DK F +++ + L+ ++ + E K + +P F TSTLQQ AS+ LG+G Sbjct: 211 KVDKIF---DEKVVKKLKKDLKDESLTIEKIEVKKKSQRPPLVFKTSTLQQLASSYLGYG 267 Query: 301 VKKTMMMAQRLYE--------AGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KTM +AQ+LYE G ITYMRTDST +S DA+NM + YI+ N+G+KY+ Sbjct: 268 ASKTMRIAQQLYEGLPIDGENKGLITYMRTDSTRISVDALNMAKDYITKNYGEKYVG-KY 326 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFVACQMTPAKYDST 411 SK N Q+AHE IRPSD+N++ + +K + + +LY+LIW +F+ Q +Y+ Sbjct: 327 VVKNSKSNVQDAHEGIRPSDINLVPDDIKVYLTNEQYRLYKLIWDRFLVSQFAAMQYEQM 386 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + GD+ + + FDG+ K+ + P + +G+ + +L + T Sbjct: 387 QINAVNGDYSFRGTINKVIFDGYYKIFK-DEDEIKTGDFPELKEGNVHPIDKLNVEEGIT 445 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPP RFSEA+LVK+LE GIGRPSTYASI+ T++ R YV + +RFY +G V D L Sbjct: 446 KPPTRFSEATLVKKLESEGIGRPSTYASIVETLKTREYVELIEKRFYPTYLGYEVKDELV 505 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 +NF+++MN FTA ME LD+V EW +L F++ +++ K EK+ EE R Sbjct: 506 KNFKDIMNVKFTANMEKELDKVEEGTVEWVQLLRAFYNSLEKEIKKFEKEIEEMKNRRVV 565 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFL----------GCSGYALPPKERCKTTINLVPENE 641 + + G+ M ++T G +L G A+ P+E K I + E E Sbjct: 566 SDVLDSE----GKPMILKTGLYGKYLISETNEKEKVSLKGIAVSPEELKKGEIFIKTEVE 621 Query: 642 VLNVLEG----EDAETNALRAKRRCPKCGTAMDSYLIDPK----------RKLHVCGNNP 687 L + + + N R + + G ++S + ++ + G Sbjct: 622 KLQNNKKGILTDYFDENGNRYVLKVGRFGEYLESENYEKDEKRMSLPAELKQKYKKGAVI 681 Query: 688 TCDGYEIEEGEFRI-----KGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRK 741 DG E + + CE CG +K GRFGK++ACT ECK + Sbjct: 682 ELDGVLQINDEMKRLQEIDRKIIEEAGVCEFCGKPYEIKTGRFGKFLACTGYPECKTIKN 741 Query: 742 IL 743 I Sbjct: 742 IK 743 >UniRef50_C8VYF5 DNA topoisomerase n=2 Tax=Firmicutes RepID=C8VYF5_DESAS Length = 721 Score = 573 bits (1478), Expect = e-162, Method: Composition-based stats. Identities = 162/732 (22%), Positives = 282/732 (38%), Gaps = 107/732 (14%) Query: 3 KALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ A+ I + L G+ Y+V ++GH+ L +K Sbjct: 2 KSLVLAEKPSVAREIARILNCTIKGKGYLEGNKYIVTWALGHLVTLAEPEDYDEKYKTW- 60 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLA 109 R P E V+ + +L ++ D + +A Sbjct: 61 ------------------RTEDLPMLPAEMKTVVIKKTGPQFHIVSKLMKRPDVRELIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQA 167 TD REGE +A + + + R+ + +T AIR+ F + + ++ Sbjct: 103 TDAGREGELVARWIMKQARC-QKPFKRLWISSLTDEAIREGFTRLRPGTEYNNLYDSAIC 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D ++G V+ L K LSAGRVQ+ + ++V RE+EIK FVP +FW V A+ Sbjct: 162 RAEADWLIGLNVTRALTVKYNAQLSAGRVQTPTLAMLVSREKEIKRFVPTDFWTVKANLG 221 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + ++ K R + Q + V+ +++ V++ + + +P + + Sbjct: 222 K-----FQAEWRDKSGKHNRFSDCLQAETIVNKVKEKSGEVIDLITQEKSEQPPLAYDLT 276 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMV---RGYISDNF 343 LQ+ A+ + G+ +KT+ Q LYE +TY RTDS L+ D V + +S + Sbjct: 277 ELQRDANKKFGYTAQKTLAGLQMLYERHKLVTYPRTDSRYLTSDMVPTLMPRLKAVSGGY 336 Query: 344 GKKYL------PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 + + P N+ + H AI P+ +L + A+ + +Y LI R+ Sbjct: 337 FAELVKPLTAKPLPINKRLVDNSKVTDHHAIIPT---TERANLAALTAEEKNIYDLIVRR 393 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE-------DRIL 450 F+A Y TT+ V A G+++ GW V + + ++ L Sbjct: 394 FIAVFYPAYSYKQTTVIVLIAGEHFHASGKVVTNPGWKAVYNNESREKDTGYDDTPEQNL 453 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRP 494 P + KGD + ++ + TKPPAR++EASL+ +E + G+G P Sbjct: 454 PPLKKGDKVKVLSCKSVKGQTKPPARYTEASLLSAMEHPGKFIEDEILKESVKESGLGTP 513 Query: 495 STYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 +T A II I YV + G + + + EL D TA+ E L +A Sbjct: 514 ATRAEIIEKIISSNYVERRGKELIPTAKGIQLVELVP---PELKQADLTAKWEQQLHDIA 570 Query: 555 NHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG 614 +++ + +K +T CP C + + G Sbjct: 571 MGKSKRTKFISGIRE----HAEKIVTTVLNSSSTFKPDNVTGNKCPKCRKFLLSVKTKRG 626 Query: 615 VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLI 674 L C + ++ K T + R CP+C Sbjct: 627 SNLVCPDRSCGHRQVEKET------------------------SNRPCPQCKKRRMEIRE 662 Query: 675 DPKRKLHVCGNN 686 K+ VC + Sbjct: 663 GKGGKIIVCTHC 674 Score = 46.6 bits (109), Expect = 0.004, Method: Composition-based stats. Identities = 12/121 (9%), Positives = 29/121 (23%), Gaps = 14/121 (11%) Query: 667 TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG 726 + + + + + K + +C KC + + G Sbjct: 567 HDIAMGKSKRTKFISGIREHAEKIVTTVLNSSSTFKPDNVTGNKCPKCRKFLLSVKTKRG 626 Query: 727 KYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDA-YFVLRDGAAGVFLAANT 785 + C + C + + PC + +R+G G + Sbjct: 627 SNLVCPDRSCGHRQVEKETSNR-------------PCPQCKKRRMEIREGKGGKIIVCTH 673 Query: 786 F 786 Sbjct: 674 C 674 >UniRef50_A9BI47 DNA topoisomerase n=3 Tax=Thermotogaceae RepID=A9BI47_PETMO Length = 762 Score = 573 bits (1476), Expect = e-161, Method: Composition-based stats. Identities = 251/793 (31%), Positives = 387/793 (48%), Gaps = 87/793 (10%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K +VIVESP+KAKTI +YLG +Y V +S GHIRDLP Sbjct: 15 SKYVVIVESPSKAKTIERYLGKEYKVIASKGHIRDLPKKEF------------------- 55 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 GVD H++E ++V+PGKEKV+ E+K+ + + LA+D+DREGEAIAW Sbjct: 56 ----------GVDIEHDFEPIFQVIPGKEKVIQEIKKETKG-RKVLLASDMDREGEAIAW 104 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL +++ D +R++F+EITKNAI+ + + P L++ +V+AQ ARR +DR+VGY +SP Sbjct: 105 HLSQILDLDPKEKNRIIFSEITKNAIKNSISNPQSLDLKKVDAQIARRILDRLVGYKISP 164 Query: 182 LLWKKIAR-GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 L+WK + SAGRVQS A++L+V++ER+I F P++++ + + +T Sbjct: 165 LVWKVLKDYKTSAGRVQSAALKLIVDKERKIFIFKPKKYFNIYLEYKGQNIP-----LTK 219 Query: 241 QNDKPFRPVNKEQTQA--AVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 ++ K +P + + + L+ + ++ E+K + KP PFITSTLQQAA + Sbjct: 220 EDGKKIKPESITKIKKDQIFEYLKDKDFKLVNVEEKESIRKPPLPFITSTLQQAAVSTFN 279 Query: 299 FGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 + K M +AQ LYE +ITYMRTDST +S +A Y+ N+GK Y+ Sbjct: 280 WASSKVMKIAQELYEGVETSEGSIAFITYMRTDSTRVSNEAQQAAINYLEKNYGKDYVGH 339 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKDM-EADAQKLYQLIWRQFVACQMTPAKYD 409 K N Q+AHEAIRP+D+N+ + K + +D KLY LIW +F+A Q P++Y Sbjct: 340 -YLSKNKKSNVQDAHEAIRPTDINMDVNNAKRLISSDHLKLYTLIWNRFMASQSAPSRYL 398 Query: 410 STTLTVG--AGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 T T+ + + + FDG+ K K + K D +T +L Sbjct: 399 EKTYTIEDNTNKYAFEITSKKCIFDGFEKFWNPNNKEVNFE----IGKNDKITYDQLKFE 454 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR-RFYAEKMGEIV 526 + T PP R++EA+L+KELE +GIGRPSTYA+IIST+ R YV + G +V Sbjct: 455 EKETNPPNRYTEATLIKELESKGIGRPSTYATIISTLLQRKYVSKIAKSTLRPTTTGFVV 514 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG 586 TD LE F E+++ FTA ME LD++ + + + K VL+ F+ +F L A + + Sbjct: 515 TDFLETYFPEIVDVKFTANMEEDLDKIEDGKNKSKVVLEQFYKEFETFLSTASNNIKNKK 574 Query: 587 MRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN-- 644 + + + C CG+ M + G++L C K ++ + E + Sbjct: 575 EILHY--ESDVPCEKCGKNMKLNFGRYGLYLSCEECKETQKIPAESFGVTIKEKLYIKEY 632 Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 + E + + +CP CG + + C N P C + + Sbjct: 633 LQETLKIDKEENKIDEKCPICGGDLILKH-GKFGEFIACSNYPECKYTRNVKARGK---- 687 Query: 705 DGPIVECEKCGSEMHLKMGRFGK-YMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPC 763 C CG ++ + GK Y C + C E C Sbjct: 688 ------CPNCGGDIVKLKSKKGKTYFKCNS--CSTMYWNEP--------------SEYSC 725 Query: 764 EKSDAYFVLRDGA 776 + Sbjct: 726 PNCGETLFYKTSK 738 Score = 74.8 bits (182), Expect = 1e-11, Method: Composition-based stats. Identities = 29/148 (19%), Positives = 50/148 (33%), Gaps = 22/148 (14%) Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPK------------ 752 V CEKCG M L GR+G Y++C + G K Sbjct: 579 YESDVPCEKCGKNMKLNFGRYGLYLSCEECKETQKIPAESFGVTIKEKLYIKEYLQETLK 638 Query: 753 -EDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKL 811 + + C +L+ G G F+A + +P+ + TR + R + P Sbjct: 639 IDKEENKIDEKCPICGGDLILKHGKFGEFIACSNYPECKYTRNV------KARGKCPNCG 692 Query: 812 RYLADAPQQDPEGNKTMVRFSRKTKQQY 839 D + + KT + + + + Sbjct: 693 ---GDIVKLKSKKGKTYFKCNSCSTMYW 717 >UniRef50_C6XXX5 DNA topoisomerase n=76 Tax=Bacteria RepID=C6XXX5_PEDHD Length = 857 Score = 572 bits (1475), Expect = e-161, Method: Composition-based stats. Identities = 279/838 (33%), Positives = 414/838 (49%), Gaps = 109/838 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESPAKAKTI YLG D++VKSS GHIRDL Sbjct: 1 MAKNLLIVESPAKAKTIEGYLGKDFLVKSSYGHIRDLV---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 M +D +N+ YEV K++VV+ELK+LA+ A+ ++LA+D DREGEAI+ Sbjct: 39 -------KGDMAIDTANNFAQTYEVPSDKKQVVAELKKLAKDAEMVWLASDEDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E +G + + R+VF+EITK AI +A P ++ + VNAQQARR +DR+VG+ +S Sbjct: 92 WHLYETLGLKENKTKRIVFHEITKPAILKAIETPRSIDYNLVNAQQARRVLDRLVGFELS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKKI LSAGRVQSVAVRL+V+RERE+ F +++ A T +G+ L Sbjct: 152 PVLWKKIKPSLSAGRVQSVAVRLIVDREREVNKFNAAAAFKITAEFVTGNGKELV----- 206 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + P R + + ++ A +SV E KP P APF TSTLQQ AS +LG+ Sbjct: 207 KAELPQRFEKEADAEKFLNDCAGAGFSVDSLETKPAKRNPAAPFTTSTLQQEASRKLGYS 266 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE- 359 V +TM +AQRLYE+G ITYMRTDS NLS+ A+ I +G KY P Y +K Sbjct: 267 VSRTMQIAQRLYESGRITYMRTDSVNLSETALQAAASEIRSAWGDKY--HQPRTYKTKSA 324 Query: 360 NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG- 418 +QEAHEAIRP+ N ++ Q+LY+LIW++ +A QM+ A ++ TT +G Sbjct: 325 GAQEAHEAIRPTYFNQHTVPG---DSSEQRLYELIWKRAIASQMSEALFEKTTAQIGIST 381 Query: 419 -DFRLKARGRILRFDGWTKVMPALRKGDE------DRILPAVNKGDALTLVELTPAQHFT 471 +L A G +L+FDG+ KV ++ + +LPA+++G ALTL + + F+ Sbjct: 382 RKEQLIAEGEVLKFDGFLKVYLESSDEEDAEDSEGNNMLPALSRGQALTLKVMNATERFS 441 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE------------------ 513 +PPAR++EASLVK+LE+ GIGRPSTYA ISTIQ+RGYV E Sbjct: 442 RPPARYTEASLVKKLEELGIGRPSTYAPTISTIQNRGYVVKEDRDGRQRSFAAIELSNGS 501 Query: 514 -------------NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 + + +GE+V D L E+F+ +++++FTA +E D++A EW Sbjct: 502 VTKKTKTEITGAEKGKLFPTDIGEVVNDFLVEHFKGIVDFNFTANVEKEFDEIAQGLQEW 561 Query: 561 KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG-- 618 +L F++ F +++ + + P G+ + + G + Sbjct: 562 TKMLHSFYTPFHLEVENTLETADRANGE-----RLLGLDPATGKNVYTKVGRFGPLVQIG 616 Query: 619 ------CSGYALPPKERCKTTINLVPENEVLNVL---EGEDAETNALRAKRRCPKCGTAM 669 YA K + T+ L E + E + ++ R P Sbjct: 617 ENDDEEKPRYASLSKSQSVGTVTLEEALEQFKLPFSLEDYQGKEVSVGVGRFGPYVKWGD 676 Query: 670 DSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYM 729 + + D E D P+ + G + GRFG ++ Sbjct: 677 AFISVPKNEDPL------SIDQARAIEIIGEKITADAPVAHYQ--GMPVTKGTGRFGPFI 728 Query: 730 ACTN-----EEC-KNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFL 781 + + R ++ E K+ + + +G G F+ Sbjct: 729 KWNDLFINVPKAYNFDRLSQQDIEELIGKKIEKEANRFIQQWPAEKIAIENGRWGPFI 786 >UniRef50_Q31J81 DNA topoisomerase n=6 Tax=Bacteria RepID=Q31J81_THICR Length = 835 Score = 568 bits (1463), Expect = e-160, Method: Composition-based stats. Identities = 279/819 (34%), Positives = 411/819 (50%), Gaps = 95/819 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 LVIVESPAKAKTI KYLG + V+SS GHIRD+ G Sbjct: 2 TNLVIVESPAKAKTIEKYLGKGFTVRSSYGHIRDIQKKG--------------------- 40 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 MG+D + + +YE+ P K+K V+EL++L ++A+ ++LATD DREGEAIAWH Sbjct: 41 --------MGIDIENGFMPNYEISPDKKKTVTELRKLTKEAETVWLATDEDREGEAIAWH 92 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L E + D R+VF+EITK AI++A +P ++++D V AQQARR +DR+VG+ +SP+ Sbjct: 93 LAEALKLDVNDTKRIVFHEITKTAIQKAIAEPRKVDMDLVEAQQARRILDRIVGFELSPI 152 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 LWKKI GLSAGRVQSVAVRL+VEREREI AF + + + + E+ + + Sbjct: 153 LWKKIRTGLSAGRVQSVAVRLIVEREREIDAFESDYVYRLQGALDILD-ESQQVVGAVEV 211 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 + +E+ QA + +++A +V + E+KP P APF TSTLQQ AS++LGF VK Sbjct: 212 KRSAAFKTEEEAQAYLEQVKEAALTVSQLEEKPAKKSPKAPFTTSTLQQEASSKLGFSVK 271 Query: 303 KTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQ 362 +TMM+AQRLYE+G ITYMRTDS NLS++A+ I FG+ Y + ++Q Sbjct: 272 QTMMIAQRLYESGKITYMRTDSVNLSEEAIQKAHDEIVSEFGESY-STTRRYKTKNADAQ 330 Query: 363 EAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD--- 419 EAHEAIRP+D +V + + + + Q+LYQLIWR+ +A QM A+ T + + Sbjct: 331 EAHEAIRPTDFSVKSVTGER---NEQRLYQLIWRRAIASQMADAQLKRTNVDIALEGMPA 387 Query: 420 FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSE 479 +L A+G ++ FDG+ KV E + LP + G AL L EL Q F++PPAR++E Sbjct: 388 EKLVAKGEVITFDGFLKVYNLDDDAKEGQ-LPPLKVGQALKLGELLVRQSFSRPPARYNE 446 Query: 480 ASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-------------------------- 513 ASLV+ LE+ GIGRPSTYA I TIQ RGYV E Sbjct: 447 ASLVRTLEEMGIGRPSTYAPTIDTIQQRGYVVKEDREGRQRDYRQLSLTVDGIDASTLTE 506 Query: 514 -----NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 + + + IVTD L ++F ++++Y FTA +E+ D +A + W+ +L F+ Sbjct: 507 TTGTEKNKLFPTDIAGIVTDFLVKHFGDVLDYKFTALVESEFDTIAQGKESWQEMLTKFY 566 Query: 569 SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG--------CS 620 F ++D A E+ + P G+ M ++ G ++ Sbjct: 567 QQFHPRVDAA----EDVSREEAGQSRALGNDPKTGKPMFVKIGRFGPYVQLGDGENEEKP 622 Query: 621 GYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 +A + T+ L E+ + + AK +I K+ Sbjct: 623 TFASLMPGQKMDTLKLEEALELFKLPREVGQMPESFSAKAVDGTEFAVEKGQIIIAKQGP 682 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC--------------GSEMHLKMGRFG 726 Y +G + V + G+++ + GR+G Sbjct: 683 FGPYLEYGPKMYAPIKGFDPLSIELEDAVALIESKIVTEAEKIIKVFPGTDVKILKGRWG 742 Query: 727 KYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 Y+ + K + +E L E P K Sbjct: 743 PYITDVTTKKNAKIKKDEDALDLSLEECQKRLDEAPEPK 781 >UniRef50_D2QCS0 DNA topoisomerase I n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QCS0_9SPHI Length = 894 Score = 567 bits (1462), Expect = e-160, Method: Composition-based stats. Identities = 272/808 (33%), Positives = 397/808 (49%), Gaps = 125/808 (15%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI YLG D+ VKSS GH+RDLP G Sbjct: 1 MSKNLVIVESPAKAKTIEGYLGKDFTVKSSFGHVRDLPKDG------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + VD + + YE+ P K+K+VSELK LA+ A+ ++LATD DREGEAI+ Sbjct: 42 ----------LAVDVTNGFRPSYEISPDKKKLVSELKSLAKSAEEVWLATDDDREGEAIS 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+E +G D R+VF EITKNAI A P +++D VNAQQARR +DR+VGY +S Sbjct: 92 WHLKEALGLRD-NTKRIVFREITKNAILNAIKSPRTIDVDLVNAQQARRVLDRLVGYELS 150 Query: 181 PLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 P+LW+KI G LSAGRVQSVA+RLVVEREREI + ++V A + L + Sbjct: 151 PVLWRKIKGGSTGLSAGRVQSVALRLVVEREREIDKHSAKSSFKVTAQFIVDGNKVLNAE 210 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 + + +A + A +++ E +P P PF TSTLQQ +S +L Sbjct: 211 LPKN------FATAAEARAFLEACVGATFTIKNLETRPAKKSPAPPFTTSTLQQESSRKL 264 Query: 298 GFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYAS 357 + V +TM +AQ LYEAG I+YMRTDSTNLSQ+A++ I FG+KY+ ++ Sbjct: 265 SYSVDRTMRIAQNLYEAGKISYMRTDSTNLSQEAIDKAVAEIGTEFGEKYI-QTRQFKTK 323 Query: 358 KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA 417 E++QEAHEAIRP++ N + + D ++LY+LIW++ +A QM A+ + TT+T+G Sbjct: 324 NESAQEAHEAIRPTNFNDRSAGG---DRDQKRLYELIWKRAIASQMADAQLERTTVTIGI 380 Query: 418 G-------------------------------DFRLKARGRILRFDGWTKVMPALRKGDE 446 L A+G +++FDG+ +V + ++ Sbjct: 381 RFANGATTTFQTNVDDSPFVETPEAIAPNRSFPNELVAQGEVIKFDGFLRVYLESKDDED 440 Query: 447 DR----ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 D +LP +N G L L ++ + FT+P R++EASLVK+LE+ GIGRPSTYA IS Sbjct: 441 DEDAKGMLPPLNIGQGLNLGQMKATEKFTRPQPRYAEASLVKKLEEMGIGRPSTYAPTIS 500 Query: 503 TIQDRGYVRVENR-------------------------------RFYAEKMGEIVTDRLE 531 TI +RGYV +++ + + G +V D L Sbjct: 501 TIVNRGYVTKQDKPGQERKYTEYTLQQNQISETSGKETYGSEKAKLFPTNTGIVVNDFLV 560 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 E F ++++Y FTA +E D++A+ W+ +L F+ DF + ++ + Sbjct: 561 EYFPDIVDYKFTATVEKEFDEIADGRMNWQTMLQDFYGDFHKNIEDIQGSSVVA---FKT 617 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVF--LGCS------GYALPPKERCKTTINLVPENEVL 643 P G+K+ R G + +G S YA + TI L ++ Sbjct: 618 GARDLGIDPRSGKKISARLGKYGAYAQIGESTDDEKPQYANLRDGQLIETITLQEALDLF 677 Query: 644 NVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNP-TCDGYEIEEGEFRIK 702 ++ + G D K ++P T D + + + Sbjct: 678 SLPREVGFFEDKPMTIGI----GKFGPYVKHDDKYVSLTKEDDPYTIDESRAIQLIQQKR 733 Query: 703 GYDGPIVECEKCGSEMHLKMGRFGKYMA 730 E G + GRFG Y+ Sbjct: 734 AEAVSEALGEFEGKMVSTGKGRFGPYVK 761 >UniRef50_Q13472 DNA topoisomerase 3-alpha n=31 Tax=Eumetazoa RepID=TOP3A_HUMAN Length = 1001 Score = 567 bits (1462), Expect = e-160, Method: Composition-based stats. Identities = 175/842 (20%), Positives = 291/842 (34%), Gaps = 95/842 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVK----SSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 K L + E AK I L + + + S I + + ++ + Sbjct: 35 KVLCVAEKNDAAKGIADLLSNGRMRRREGLSKFNKIYEF-DYHLYGQNVTMVMTSVSGHL 93 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEV--LPGKEKVVSELKQLAEKADHIYLATDLDREG 116 D + +P +EA E + L++ + + + TD DREG Sbjct: 94 LAHDFQMQFRKWQSCNPLVLFEAEIEKYCPENFVDIKKTLERETRQCQALVIWTDCDREG 153 Query: 117 EAIAWHLREVIG--GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E I + + V + + R F+EIT +A+R A E + +A R+ +D Sbjct: 154 ENIGFEIIHVCKAVKPNLQVLRARFSEITPHAVRTACENLTEPDQRVSDAVDVRQELDLR 213 Query: 175 VGYMVSPLLWKKIAR---------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G + ++ R +S G Q + VVER + I+AFVPE F + + Sbjct: 214 IGAAFTRFQTLRLQRIFPEVLAEQLISYGSCQFPTLGFVVERFKAIQAFVPEIFHRIKVT 273 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLL-EKARYSVLEREDKPTTSKPGAPF 284 G + N K R N L E +V+E KP + Sbjct: 274 HDHKDG------IVEFNWKRHRLFNHTACLVLYQLCVEDPMATVVEVRSKPKSKWRPQAL 327 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA------VNMVRGY 338 T L++ AS +L K+TM +A++LY GYI+Y RT++ +D Sbjct: 328 DTVELEKLASRKLRINAKETMRIAEKLYTQGYISYPRTETNIFPRDLNLTVLVEQQTPDP 387 Query: 339 ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 F + L + S +AH I P+ +++ D Q+LY+ I R F Sbjct: 388 RWGAFAQSILERGGPTPRNGNKSDQAHPPIHPTKYT------NNLQGDEQRLYEFIVRHF 441 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 +AC A+ TT+ + R A G ++ + V P D +ILP +G Sbjct: 442 LACCSQDAQGQETTVEIDIAQERFVAHGLMILARNYLDVYPYDHWSD--KILPVYEQGSH 499 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-NRRF 517 + T PP +EA L+ +EK GIG +T+A I TI+ R YV + ++RF Sbjct: 500 FQPSTVEMVDGETSPPKLLTEADLIALMEKHGIGTDATHAEHIETIKARMYVGLTPDKRF 559 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 +G + + + E+ D A++E L + + + + VL + Q + Sbjct: 560 LPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICDGKKDKFVVLRQQVQKYKQVFIE 619 Query: 578 AEKDPEEGGMRP-----------------NQMVLTSIDCPTCGRKMGIRTASTGVFL-GC 619 A ++ M CP C + M ++T G F C Sbjct: 620 AVAKAKKLDEALAQYFGNGTELAQQEDIYPAMPEPIRKCPQCNKDMVLKTKKNGGFYLSC 679 Query: 620 SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR- 678 G+ C++ + L D+ A R CP C L + Sbjct: 680 MGFP-----ECRSAVWLP------------DSVLEASRDSSVCPVCQPHPVYRLKLKFKR 722 Query: 679 ---------KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYM 729 + C CD E P + + + R Sbjct: 723 GSLPPTMPLEFVCCIGG--CDDTL-REILDLRFSGGPPRASQPSGRLQANQSLNRMDNSQ 779 Query: 730 ACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL----RDG--AAGVFLAA 783 + + T + PP + C VL ++G F Sbjct: 780 HPQPADSRQTGSSKALAQTLPPPTAAGESNSVTCN-CGQEAVLLTVRKEGPNRGRQFFKC 838 Query: 784 NT 785 N Sbjct: 839 NG 840 Score = 44.7 bits (104), Expect = 0.016, Method: Composition-based stats. Identities = 14/58 (24%), Positives = 20/58 (34%), Gaps = 3/58 (5%) Query: 754 DPVPLPELPCEKSDAYFVLRDGAAGVFL-AANTFPKSRET--RAPLVEELYRFRDRLP 808 +P P C + + VL+ G F + FP+ R V E R P Sbjct: 649 PAMPEPIRKCPQCNKDMVLKTKKNGGFYLSCMGFPECRSAVWLPDSVLEASRDSSVCP 706 >UniRef50_A8EWX5 DNA topoisomerase I n=2 Tax=Campylobacterales RepID=A8EWX5_ARCB4 Length = 756 Score = 566 bits (1459), Expect = e-159, Method: Composition-based stats. Identities = 255/733 (34%), Positives = 380/733 (51%), Gaps = 70/733 (9%) Query: 29 SSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPG 88 +S+GH+RDLP S +G DP N++ Y++ Sbjct: 2 ASMGHVRDLPKSS-----------------------------LGFDPNDNFKPKYQISTD 32 Query: 89 KEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIR 148 K+KV+++LK+ K IYLA D DREGEAIAWHL + + R+VF+EITK+AI Sbjct: 33 KKKVITDLKKHISKDTTIYLAADEDREGEAIAWHLIPALKIEKNPIKRIVFHEITKDAIL 92 Query: 149 QAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERE 208 +A P +++ + V+AQQARR +DR VGY +SPLLWKK+ GLSAGRVQSVAVR++V+RE Sbjct: 93 KALENPRDVDQNLVDAQQARRILDRAVGYELSPLLWKKVRYGLSAGRVQSVAVRIIVDRE 152 Query: 209 REIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSV 268 EI+AFVPEE+W++ A P L ++ +N K + N++Q + L++ Y + Sbjct: 153 NEIRAFVPEEYWKIKADFINPE---LKAELAKENGKTLKISNEKQALEIEASLKQGSYKL 209 Query: 269 LEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE----------AGYIT 318 ++ E+K +T P APF TSTLQQ AS +LGF VK+TM++AQ+LYE G IT Sbjct: 210 VDIEEKESTRNPAAPFTTSTLQQEASRKLGFSVKQTMIIAQQLYEGNVGNIPNHTGGLIT 269 Query: 319 YMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMA 377 YMRTDS NLS A + I + +GK+Y P Y +K + +QEAHEAIRP ++ + Sbjct: 270 YMRTDSLNLSTVATTAAKAVIEEEYGKEYALNKPRVYTTKSKGAQEAHEAIRPVNLALRP 329 Query: 378 ESLKDM-EADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG---DFRLKARGRILRFDG 433 +K+ E +LY LIW++ +A QM AK +TT + AG +F + +G+ + F G Sbjct: 330 SQIKEFVEPAQYRLYSLIWKRTLATQMAQAKIANTTYKIEAGKNKEFEFQVKGQRIIFAG 389 Query: 434 WTKVMPALRKGDE------DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE 487 + K E ++ILP + +G L L +L Q+FTKPPAR++EASLVK+LE Sbjct: 390 FMKAYTEGSDNPEAALDSSEKILPNIKEGTILELEKLESEQNFTKPPARYTEASLVKKLE 449 Query: 488 KRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546 GIGRPSTYA ISTIQ R YV E+ + + GEIV L ++F +++ FTA++ Sbjct: 450 SEGIGRPSTYAPTISTIQAREYVSKTEDNKLIPTQTGEIVNSFLVDHFSNIVDLGFTAKI 509 Query: 547 ENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKM 606 E D++A + W+ V+ +F+ F + +D + V P G+ + Sbjct: 510 EEEFDEIAEGKIAWEEVMKNFYGGFKKTID---EKESSVSKEDYLQVNELGIDPKSGKPV 566 Query: 607 GIRTASTGVFLGCSGYALPPKERCKT--------TINLVPENEVLNVLEGEDAETNALRA 658 R G F+ K + TI L + N+ N Sbjct: 567 SARVGRFGPFVQIGTKDDEEKPKFVAIPDNLNMDTITLEEALFLFNLPRVVGNTENGDEI 626 Query: 659 KRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE-EGEFRIKGYDGPIVECEKCGSE 717 K + G + + + ++P E I + Sbjct: 627 KANIGRFGPYLQVKT----KFYSLKTDDPYTIDLNRALEIIKDIDEAKEKSTIKTFDKEK 682 Query: 718 MHLKMGRFGKYMA 730 + + +G++G Y+ Sbjct: 683 IQILVGQYGPYIK 695 >UniRef50_Q6XZ01 DNA topoisomerase n=2 Tax=Spiroplasma RepID=Q6XZ01_SPIKU Length = 664 Score = 566 bits (1459), Expect = e-159, Method: Composition-based stats. Identities = 248/709 (34%), Positives = 377/709 (53%), Gaps = 75/709 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVI+ESP K K + KYLG +Y+V SS GHIR+L T G Sbjct: 1 MAQTLVIMESPTKTKAVEKYLGENYLVLSSEGHIRNLSTKGQYG---------------- 44 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD +E Y++ GK++++ +LKQ A+ AD I LATD DREGEAIA Sbjct: 45 ----------LGVD-IKTFEPSYKMERGKKEIIKKLKQEAKAADLIILATDPDREGEAIA 93 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 +HL EV+ + RV FNEITK A+ +AF +L+++ V++Q+ RR +DR +G+ +S Sbjct: 94 YHLNEVLNCGEKS-RRVRFNEITKEAVLEAFQHQTDLDMNLVHSQETRRILDRFIGFRLS 152 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 LL KKI SAGRVQSVA++LVVERE+E + FVPEE+W V+ +++T Sbjct: 153 KLLQKKIKSK-SAGRVQSVALKLVVEREKEWQNFVPEEYWTVEGLYKKA-----VVKLTK 206 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 D + K + V++ ++ K P TST+ Q AS+++GF Sbjct: 207 FKDYKIELKVEADVLKVKKA-LKKDFVVVQIKESEKQRKSPNPHTTSTMLQEASSKMGFA 265 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 KT ++AQ+LYE G+ITY RTDS LS V YI+ +G +YL Sbjct: 266 SNKTSLIAQQLYEGIKVKDNITGFITYPRTDSIRLSDKFVQDAFDYITIKYGTEYLGGVK 325 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKYDST 411 Q +K+N Q+AHEAIRP+D+ + E+ K+ + D +LY++I+ + +A M AK S Sbjct: 326 TQPKNKKNVQDAHEAIRPTDLTMTPEAAKEYLSRDQIRLYKIIYNRSLASLMANAKLLSK 385 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + + ++ + G ++FDG+ K L +E LP + + L EL QHFT Sbjct: 386 AIILDNNNYEFRMTGSTIQFDGFLKCY-FLEGNEEIVKLPMLKPNQIINLNELYGIQHFT 444 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 KPP+ +SEA L+K LE+ G+GRPSTYA I+ T++DRGY+ VEN+ A + G + +D+L+ Sbjct: 445 KPPSHYSEAKLIKTLEEIGVGRPSTYAPIMQTLKDRGYIIVENKAIKATEKGILTSDKLQ 504 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 E F +++N +T+ +E SLD +A+ +AE K +L F+ F +++ + E Sbjct: 505 EYFSDIINETYTSTIEKSLDMIAHGDAEPKPLLKEFWERFEPRIEATMELME-----EIP 559 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 + + I+CP CG + R G F+ CSG+ +C P+ Sbjct: 560 VEKSGIECPECGNDLVYRYGKYGKFIACSGFP-----KCHYIHQTGPKFG---------- 604 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKR-KLHVCGNNPTCDGYEIEEGEF 699 CP+CG + +R + C N P C+ + + E Sbjct: 605 ---------PCPECGVGEIILKFNKRRQRFKACTNYPNCNYTDSYKEEK 644 Score = 64.0 bits (154), Expect = 2e-08, Method: Composition-based stats. Identities = 18/101 (17%), Positives = 38/101 (37%), Gaps = 17/101 (16%) Query: 703 GYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPEL 761 + +EC +CG+++ + G++GK++AC+ +C + Sbjct: 559 PVEKSGIECPECGNDLVYRYGKYGKFIACSGFPKCHYIHQTGPKFG-------------- 604 Query: 762 PCEKSD-AYFVLRDGAAG-VFLAANTFPKSRETRAPLVEEL 800 PC + +L+ F A +P T + E+ Sbjct: 605 PCPECGVGEIILKFNKRRQRFKACTNYPNCNYTDSYKEEKT 645 Score = 57.4 bits (137), Expect = 2e-06, Method: Composition-based stats. Identities = 14/89 (15%), Positives = 30/89 (33%), Gaps = 17/89 (19%) Query: 755 PVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYL 814 PV + C + V R G G F+A + FPK + Sbjct: 559 PVEKSGIECPECGNDLVYRYGKYGKFIACSGFPKCHYIHQTGPKFG-------------- 604 Query: 815 ADAPQQDPEGNKTMVRFSRKTKQQYVSSE 843 P + + +++F+++ ++ + Sbjct: 605 ---PCPECGVGEIILKFNKRRQRFKACTN 630 Score = 56.3 bits (134), Expect = 6e-06, Method: Composition-based stats. Identities = 27/208 (12%), Positives = 53/208 (25%), Gaps = 19/208 (9%) Query: 544 AQMENSLDQVANHE-AEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTC 602 A++ +L+++ + + ++ ++ E G+ + + Sbjct: 453 AKLIKTLEEIGVGRPSTYAPIMQTLKDRGYIIVENKAIKATEKGILTSDKLQEYFSDIIN 512 Query: 603 GRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRC 662 S + P + + E ++ C Sbjct: 513 ETYTSTIEKSLDMIAHGDAEPKPLLKEFWERF-----EPRIEATMELMEEIPVEKSGIEC 567 Query: 663 PKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC--GSEMHL 720 P+CG + Y K C P C I C +C G + Sbjct: 568 PECGNDLV-YRYGKYGKFIACSGFPKCHY---------IHQTGPKFGPCPECGVGEIILK 617 Query: 721 KMGRFGKYMACTN-EECKNTRKILRNGE 747 R ++ ACTN C T Sbjct: 618 FNKRRQRFKACTNYPNCNYTDSYKEEKT 645 >UniRef50_C3JAB5 DNA topoisomerase n=3 Tax=Bacteria RepID=C3JAB5_9PORP Length = 837 Score = 566 bits (1458), Expect = e-159, Method: Composition-based stats. Identities = 263/803 (32%), Positives = 385/803 (47%), Gaps = 103/803 (12%) Query: 1 MGKA--LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 M K LVIVESPAKAKTI K+LG + V SS GHIRDL SG Sbjct: 50 MQKTPNLVIVESPAKAKTIEKFLGKGFRVLSSYGHIRDLKKSG----------------- 92 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEA 118 +G+D + +Y V K VV +LK A+ A+ ++LA+D DREGEA Sbjct: 93 ------------LGIDISQQFAPNYIVSKDKLAVVRDLKHAADNAEMVWLASDEDREGEA 140 Query: 119 IAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 IAWHL EV+ R+VF+EIT+ AI A P +++++ V+AQQARR +DR+VG+ Sbjct: 141 IAWHLYEVLERAGKPTKRIVFHEITQQAIDYAIAHPRDIDLNLVDAQQARRVLDRIVGFE 200 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP-SGEALALQ 237 +SP+LWK+I LSAGRVQSVAVRL+V+REREI+ F P ++V AS GE L Sbjct: 201 LSPILWKRIKPALSAGRVQSVAVRLIVDREREIQQFSPSSSYKVIASLCKQTEGETLQAI 260 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRL 297 D E+ + +S VL KP P APF TSTLQQ A+ +L Sbjct: 261 AEKTFD------TAEEAKNFLSRNSAQEMEVLSLVSKPGKRSPAAPFTTSTLQQEAARKL 314 Query: 298 GFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYAS 357 G+ V TM +AQ+LYE+G+ITYMRTDS NLS A+N I + +G+ Y + Sbjct: 315 GYTVGTTMRIAQKLYESGHITYMRTDSVNLSTLALNSAAKAIKERWGESYY-QLRKYKTK 373 Query: 358 KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTV-- 415 + +QEAHEAIRP+D + ES+ QKLY++I ++ +A QM + TT T Sbjct: 374 SKGAQEAHEAIRPTD--LSKESISG-TPQEQKLYEMIHKRTLASQMADVVLEKTTATFRG 430 Query: 416 GAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI------LPAVNKGDALTLVELTPAQH 469 + A G ++RF+G+ K DE+ LP ++KG+ L EL +H Sbjct: 431 QTSNDVFVAEGEVIRFEGFLKAYDYASHSDEEEEKNNSHQLPTLSKGELLNTQELVATEH 490 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV----------------- 512 T+ PAR+SEASLV+ LE+ GIGRPSTYA I IQ R YV+ Sbjct: 491 ITRAPARYSEASLVRRLEELGIGRPSTYAPTIQVIQAREYVQKGTGNGTEHQYHDYICNA 550 Query: 513 ----------------ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 + + +G +V D L ENF ++++Y+FTAQ+E D++A Sbjct: 551 QHPTPTLKIRTEKIGADKGKLLPTDIGIVVNDFLVENFPKVIDYNFTAQVEGLFDRIAEG 610 Query: 557 EAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVF 616 + W ++HF++ F ++ A + + + P+ + + R G Sbjct: 611 KEIWTNTMEHFYTLFHPMVETALESFDNHA----RGERLLGVDPSTNKAVMARIGRYGPL 666 Query: 617 LGCSG--------YALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 + +A + + TI L ++ + + K + G Sbjct: 667 VQIGENTPTEKASFASLREGQSIQTITLEEALDLFKLPRTP-GQFEGNDVKVASGRFGPY 725 Query: 669 MD---SYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRF 725 + + PK+ + C + E IK E + + ++ GRF Sbjct: 726 IQHAGKFTSIPKQYDPLSITLDECIALIQAKREEEIKAELKRFSEDPE----LTIRTGRF 781 Query: 726 GKYMACTNEECKNTRKILRNGEV 748 G ++ E K +++ Sbjct: 782 GPFLKHGKENYKLSKEQKERAAE 804 >UniRef50_A4J356 DNA topoisomerase n=3 Tax=Clostridia RepID=A4J356_DESRM Length = 799 Score = 563 bits (1452), Expect = e-159, Method: Composition-based stats. Identities = 178/832 (21%), Positives = 300/832 (36%), Gaps = 107/832 (12%) Query: 3 KALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADST 51 K LVI E P+ K I LG Y+V + GH+ +L Sbjct: 2 KTLVITEKPSVGKDIASVLGRFESKDGYLENEKYIVSWAFGHLVELADPSVYDPVFKKWD 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAE--KADHIYLA 109 P + E+ K + LK+L + + Sbjct: 62 LATLPIIPDSFKL------------------VEIAGSSAKQLRTLKKLLNSAEVSQVVNG 103 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQA 167 D REGE+I + G R+ +E T A++ AF E + A +A Sbjct: 104 CDAGREGESIFRRIYHFCGCR-KPIKRLWLSETTPAAVKAAFKALREGQEYNNLAAAAEA 162 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D +VG + + LS GRVQ+ + L+V REREI FVP +WEV + Sbjct: 163 RGQADWLVGLNGTRAFTVRHGTVLSVGRVQTPTLNLIVSREREINNFVPVPYWEVWGTFQ 222 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTSKPGAPFIT 286 T +G +K R N+E + L A+ V+ E K P F Sbjct: 223 TDNGMYKGKWF---REKEDRLPNREAALNLTTKLSSEAKGQVISLEQKEAKELPSFLFNL 279 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYIS----D 341 + LQ+ + R GF ++ + +AQ LYE +TY RTDS +LS ++ + ++ Sbjct: 280 NDLQKEGNRRYGFTAQQVLDIAQSLYEKHKLLTYPRTDSRHLSNAMISTLPERLATLKNA 339 Query: 342 NFGKKYLPESPN---QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 + +P++ + + H AI P+ V+ + +K+Y L+ R+F Sbjct: 340 PKYAELIPDTLPGLSKRYVDDGKITDHHAIIPTAVDPSKAQ---LSDQEKKIYDLVVRRF 396 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR---------KGDEDRI 449 ++ A+Y T + K+RGR+ GW V ED+ Sbjct: 397 LSIFYPEARYAVTEVFTETAGELFKSRGRVELAAGWKMVWRGSDQETAEEGNGDDPEDQA 456 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR-----------------GIG 492 LP + +G ++ + ++ + TKPP RF+EA+++ +E GIG Sbjct: 457 LPPLTQGKSVDVSKVEILEKQTKPPKRFTEATILAAMESAGKFVEDKEMAEVLKQTGGIG 516 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 P+T A+II + GYV + + G+I+ D + + +L + + TA E+ L + Sbjct: 517 TPATRAAIIERLIKVGYVARDKKSLVPTAKGQILIDLVPK---QLKSVELTASWEDGLRR 573 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAS 612 V + + + + + A G+ T CP CGR + S Sbjct: 574 VEEGQQNAALWIQDIQAYTRELVVLARNQEVSQGV--GTARDTLGKCPVCGRDVVETAKS 631 Query: 613 TGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSY 672 G CSGY KE CK I ++ ++ + E T + + Sbjct: 632 YG----CSGY----KEGCKFAIWKEINSKKISAKQAETLLTKGKTGL---------IKGF 674 Query: 673 LIDPKRKLHV----CGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKY 728 + + G+ + + + +C CG ++ +G Sbjct: 675 KSKAGKTFDALLVLGEDGKITFGFANAVNDQPGSTGNTALGKCPLCGKDVVENSRSYG-- 732 Query: 729 MACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVF 780 C+ + I R + + G G F Sbjct: 733 --CSGYKDGCKFVIWREIAKKKITQTQAIELLAKGKT--GIIKGFKGQKGSF 780 >UniRef50_A4RYV6 DNA topoisomerase (Fragment) n=5 Tax=cellular organisms RepID=A4RYV6_OSTLU Length = 840 Score = 563 bits (1451), Expect = e-159, Method: Composition-based stats. Identities = 241/807 (29%), Positives = 368/807 (45%), Gaps = 113/807 (14%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 + L+IVESPAKAKTI KYLG++ V +S GH+RDL Sbjct: 67 KRTLMIVESPAKAKTIEKYLGANAKVLASYGHVRDLVNKQG------------------- 107 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 V P ++ + ++ + ++ + +K D + LATD DREGEAI+W Sbjct: 108 ----------SVRPEESFAMTWTSTSRQKAAMRDITEALKKTDVLLLATDPDREGEAISW 157 Query: 122 HLREVIGGDD-----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 HL EV+ RV F EITK A+ A P ++N+ V+A ARR +D + G Sbjct: 158 HLLEVLREKKLLRDDLDVKRVTFGEITKTAVLDAVGSPRDINVPMVDAYMARRALDYLFG 217 Query: 177 YMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEAL 234 + +S LLW+K+ LSAGRVQSVA+RLV ERE E++AFV E +W V AS ++ G Sbjct: 218 FTLSGLLWRKLPSSVSLSAGRVQSVALRLVCEREEEVEAFVSEPYWTVKASLSSKDGSTF 277 Query: 235 ALQVTHQND---KPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTSKPGAPFITSTLQ 290 +TH + F + ++ +A + + V+E + G PF TST+Q Sbjct: 278 DAALTHVDGAKLGKFTIASNDEAEAYAKRVRECDTLRVVEVKHSEAKRTSGPPFTTSTMQ 337 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA-----GYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 Q A+ +LGFG +TM AQRLYE G ITYMRTD T ++ A+ +R + FG Sbjct: 338 QEANKQLGFGASRTMSAAQRLYEGAGTGEGLITYMRTDGTYVAPHAIESLRTTAGELFGD 397 Query: 346 KYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESLKDM---EADAQKLYQLIWRQFVAC 401 +Y+PESP + K +N+QEAHEAIRP+ + + +D +LY LIW + +A Sbjct: 398 EYVPESPRYFKKKQKNAQEAHEAIRPTKAGRLPAQVARQIGPGSDEARLYALIWARTMAS 457 Query: 402 QMTPAKYDSTTLTVGA--GDFRLKARGRILRFDGWTKVM----PALRKGDEDRILPAVNK 455 QM+PA D + + D +LKA G L+F G+ P +D LP + + Sbjct: 458 QMSPALTDRIAAEIASAENDLKLKANGHRLKFPGFLAAYRTSRPEAAPPSDDAWLPILGE 517 Query: 456 GDALTLVE------LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 G+ L++ +H T PP R+++ S+VK LE+RGIGRPSTYA I+ + R Y Sbjct: 518 GEGLSVKTDGESLGCEATEHKTSPPPRYTDGSIVKALEERGIGRPSTYAPILKVLAQREY 577 Query: 510 VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 V + G +V+ L F ++Y FTA +E+ LD + + + +WK +L+ +++ Sbjct: 578 VAKQGAALVPTTRGRLVSAFLTNYFETYVDYGFTADLEHKLDDITSEQVQWKPLLEEWWT 637 Query: 570 DFTQQL----------------DKAEKDPEEGGMRPNQMVLTSIDCPTCG-RKMGIRTAS 612 F ++ +K + + +V + CP+C ++G++ + Sbjct: 638 PFRDKISSLSELRVSEVIDALDEKLGQHLFGEATDSDDVVSEARRCPSCKIGRLGLKPSK 697 Query: 613 TGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNA---------LRAKRRCP 663 G F+GCS Y C T L P + + + P Sbjct: 698 AGGFIGCSRYP-----ECGFTHPLHPIRGAIVSDTDDPDFVATVEDPDAVMYPKVLGVDP 752 Query: 664 KCGTAMDSYLIDPKRKLH--------------------VCGNNPTCDGYEIEEGEFRIKG 703 G + L P N + Sbjct: 753 ATGKEISLRL-GPYGPYLQLGDGKKAKKPKKPPAPRRVGVANIGKDVNKITLAEAIGMFE 811 Query: 704 YDGPIVECEKCGSEMHLKMGRFGKYMA 730 Y + + + L +G FG Y+A Sbjct: 812 YPKVLGVHPVTQAPVSLNIGPFGWYVA 838 Score = 44.3 bits (103), Expect = 0.019, Method: Composition-based stats. Identities = 9/48 (18%), Positives = 14/48 (29%), Gaps = 1/48 (2%) Query: 751 PKEDPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRETRAPLV 797 D V C L+ AG F+ + +P+ T Sbjct: 671 TDSDDVVSEARRCPSCKIGRLGLKPSKAGGFIGCSRYPECGFTHPLHP 718 >UniRef50_B6YTB3 DNA topoisomerase n=4 Tax=Thermococcus RepID=B6YTB3_THEON Length = 717 Score = 562 bits (1449), Expect = e-158, Method: Composition-based stats. Identities = 172/759 (22%), Positives = 305/759 (40%), Gaps = 62/759 (8%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+I E P A+ I L V+ ++G + + + K + Sbjct: 3 TLIIAEKPNVARKIAYALAEGRPVRKTIGKVPYYEFTRDGKRIIVAPAVGHLFSLAPKTK 62 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAIA 120 W Y GK + + L LA++AD +A D D EGE I Sbjct: 63 TYGYP-----VFDIEWVPVYVAEKGKSYAKDYIKALATLAKRADEFVVACDYDTEGEVIG 117 Query: 121 WHLREV-IGGDDARYSRVVFNEITKNAIRQAFNKPGE-LNIDRVNAQQARRFMDRVVGYM 178 + + G D ++ R+ F+ +TK + +A+ +N +A AR +D G Sbjct: 118 YTALKYACGVDPSKAKRMKFSALTKKDLLKAWYNLESTINFGMADAGIARHVLDWYWGVN 177 Query: 179 VSPLLWKKIAR------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE 232 +S L I R LS GRVQ ++ +V+RE+EI+ F P +W + + Sbjct: 178 LSRALTSAIKRASGKWMVLSTGRVQGPTLKFLVDREKEIQNFKPTPYWVIKMVLEKNGQQ 237 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 A+ + R +++ + + V +K V + + K P PF TLQ+ Sbjct: 238 YTAVY------EKERILDENEAKRIVEEAKKGPAFVEKVDVKQQNRHPPVPFDLGTLQRE 291 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD------AVNMVRGYISDNFGKK 346 A + G+ KKT+ +AQ+LYE G +Y RT S L ++ N+ + F + Sbjct: 292 AYSAFGYSPKKTLELAQKLYERGLTSYPRTSSQKLPKNLNFRSILQNLAKLPEYKPFAHE 351 Query: 347 YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPA 406 L + + + AH AI P+ ++ D LY LI R+F+A M PA Sbjct: 352 LLGKERLKPVEGKKDDPAHPAIYPTGELPKP---GELTKDEANLYDLIVRRFLALFMEPA 408 Query: 407 KYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTP 466 + + + + R G +GW KV K DE ILPA +G+ + ++++ Sbjct: 409 VREIMKVIINSNGHRFILSGARTIKEGWLKVYGKYVKFDE-AILPAFKEGEPVKVLQIKR 467 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 + TKPPAR+S A+++K +E GIG +T A I+ T+ RGY+ + + +G V Sbjct: 468 EKKKTKPPARYSPAAVIKRMEDLGIGTKATRAQILETLYSRGYIEGKKK-IKVTPLGMRV 526 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG 586 + LE N ++++ + T E ++++ +A+ V++ + L + ++ + G Sbjct: 527 VEALERNVPDIVSVELTRAFEEKMEEIMAGKADKDRVIEESKEQLIKILQQFKEKELDIG 586 Query: 587 MRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVL 646 + T + + T+ + E E +V Sbjct: 587 KVLMETTGTGVTT------------------------SKENAKRAGTVKELSETEEKDVK 622 Query: 647 EGEDAETNALRAKRRCPKCGTA-MDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYD 705 + + +CPKCG + Y ++ C N P C+ RI + Sbjct: 623 KTIEKGEKTPLVVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVTYPLLQRGRIIPTN 682 Query: 706 GPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILR 744 G+ + + +Y C + CK+ +K + Sbjct: 683 KTCC----DGAPVVKIREKGREYEICLDMNCKDWKKGKK 717 Score = 50.9 bits (120), Expect = 2e-04, Method: Composition-based stats. Identities = 21/129 (16%), Positives = 41/129 (31%), Gaps = 27/129 (20%) Query: 739 TRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAA--GVFLAANTFPKSRETRAPL 796 + ++ + K + PL C K V+R F+ + +PK T L Sbjct: 614 SETEEKDVKKTIEKGEKTPLVVGKCPKCGGDLVVRYNRKTGKRFVGCSNWPKCNVTYPLL 673 Query: 797 VEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGKATGWSAFYV 856 + +P + +G V+ K ++ + + + K Sbjct: 674 -----QRGRIIPTN--------KTCCDGAPV-VKIREKGREYEICLDMNCK--------- 710 Query: 857 DGKWVEGKK 865 W +GKK Sbjct: 711 --DWKKGKK 717 >UniRef50_Q1AY08 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AY08_RUBXD Length = 701 Score = 562 bits (1447), Expect = e-158, Method: Composition-based stats. Identities = 159/716 (22%), Positives = 271/716 (37%), Gaps = 87/716 (12%) Query: 5 LVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 L++ E P+ + I LG +VV ++GH+ +L + + + Sbjct: 3 LIVAEKPSVGRDIAGALGRHRREGDALVGSGWVVTWALGHLAELAPPDAYGAEYKRWSLQ 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK--ADHIYLATD 111 P+ V P + +++ + A D Sbjct: 63 NLPILPE-------------------RFRVRVNPRTRERFEAVRRWMRDPSVTEVVNACD 103 Query: 112 LDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARR 169 REGE I +L ++ + R+ + +T AIR+ F + +A ++R Sbjct: 104 AGREGELIFAYLYQLSRCE-KPVRRLWVSSLTPEAIREGFGSLRDGPSMKPLEDAARSRA 162 Query: 170 FMDRVVGYMVSPLLWKKIAR---GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D +VG + + +R LS GRVQ+ +RL+VEREREI+ F PE F+ V A Sbjct: 163 EADWIVGMNATRAYSVRFSRPGDVLSVGRVQTPTLRLLVEREREIEDFRPERFFTVHARF 222 Query: 227 TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFIT 286 L +K R +E + + V + E + T+ +P + Sbjct: 223 ARDGKTYDGLWF---REKESRLKEREAAEQIAEKVRGGTGVVKKAERRRTSERPPLLYDL 279 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGYISD---- 341 + LQ+ A+ R GF ++T+ AQ LYE ITY RT S LS D V ++ + Sbjct: 280 TELQRNANARYGFTAERTLRAAQALYEERKLITYPRTSSRYLSGDMVGTLKRRVEAAGGL 339 Query: 342 ----NFGKKYLPESPN---QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 F + L + ++ H AI P+D + D K+Y L+ Sbjct: 340 PELAPFAGRLLAAGSLPVGRRVVDDSKVTDHHAIVPTDRKPS----GGLPPDEAKVYDLV 395 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPA---LRKGDEDRILP 451 R+F+A A++++TT+ A ++GR++ GW ++ P RK E LP Sbjct: 396 ARRFLAVFFPAARFENTTVVTEARGETFLSKGRVVLEAGWRELYPDGVGGRKEKEPPALP 455 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRPS 495 V G + ++ + TKPP R+SE++L+ +E G+G P+ Sbjct: 456 PVEAGQEWRVAKVGVKEGETKPPPRYSESALLGAMETAGKLVEDEELRQQMKDSGLGTPA 515 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 T A+II + GYV E + G + L + L + + TA+ E L ++ Sbjct: 516 TRAAIIERLIKVGYVEREKKALVPTAKGRALISLLAD--SPLSSPEMTARWERRLARIER 573 Query: 556 HEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV 615 E + ++ + E P CP CG + + G Sbjct: 574 GEERRPDFMSDISGFAASVVEGVRRMEGEKIAAPGGGGEALGACPKCGSPVVETKKAYG- 632 Query: 616 FLGCSGYALPPKERCKTTINLVPENEVLNVLEGED--AETNALRAKRRCPKCGTAM 669 CS + K C I + ++ + A+ R K + G Sbjct: 633 ---CSAW---RKTGCDFAIWKRVAGKRVSESQARQLLAKGRTARLKGFKSRAGKPF 682 >UniRef50_O95985 DNA topoisomerase 3-beta-1 n=72 Tax=Eukaryota RepID=TOP3B_HUMAN Length = 862 Score = 562 bits (1447), Expect = e-158, Method: Composition-based stats. Identities = 180/802 (22%), Positives = 297/802 (37%), Gaps = 69/802 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVK------SSVGHIRDLPTSGSAAKKSADSTSTK 54 M L++ E P+ A++I K L + + H +G + S Sbjct: 1 MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGH 60 Query: 55 TAKKPKKDERGALVNRMGVDPWHNW-EAHYEVLPG--KEKVVSELKQLAEKADHIYLATD 111 D G VDP + +A E K +V L+ D+I L D Sbjct: 61 VMTL---DFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLD 117 Query: 112 LDREGEAIAWHLREV-------IGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNA 164 D+EGE I + + + G + R F+ IT I A GE + + + Sbjct: 118 CDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALS 177 Query: 165 QQARRFMDRVVGYMVSPLLWKKIARG--------LSAGRVQSVAVRLVVEREREIKAFVP 216 AR+ +D +G + K +S G Q+ + VER +I++F P Sbjct: 178 VDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKP 237 Query: 217 EEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLE-KARYSVLEREDKP 275 E +W + A T +L L R ++E Q +++ + + V K Sbjct: 238 ETYWVLQAKVNTDKDRSLLLDWDRV-----RVFDREIAQMFLNMTKLEKEAQVEATSRKE 292 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVN 333 + T + + AS+ LG G + M A+RLY GYI+Y RT++T+ + D Sbjct: 293 KAKQRPLALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKG 352 Query: 334 MVRGYISDNFG----KKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQK 389 +R + + K+ L E N+ K + H I P AE + DA + Sbjct: 353 SLRQQANHPYWADTVKRLLAEGINRP-RKGHDAGDHPPITPMKSATEAE----LGGDAWR 407 Query: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI 449 LY+ I R F+A KY +T++ G G+ + G+T+VMP E+ Sbjct: 408 LYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEES- 466 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGY 509 LP +GDA + E+ + T PP +EA L+ +EK GIG ++ I+ I R Y Sbjct: 467 LPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNY 526 Query: 510 VRVE-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH-- 566 V VE RR +G ++ + EL+ + +E L+ +A +A+++ VL H Sbjct: 527 VTVESGRRLKPTNLGIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTL 586 Query: 567 --FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGR--KMGIRTASTGVFLGCSG- 621 F F +D E + + + T CG+ + + L CS Sbjct: 587 DVFKRKFHYFVDSIAGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHC 646 Query: 622 ---YALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR 678 Y LP K L + ++ ++ CP C + Sbjct: 647 DETYTLPQNGTIKLYKELRCPLDDFELVLWSSGSRG--KSYPLCPYCYNHPPFRDMKKGM 704 Query: 679 KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKN 738 + C +P+C G I +C +C S + + G +C Sbjct: 705 GCNECT-HPSCQHSLSMLG----------IGQCVECESGVLVLDPTSGPKWKVACNKCNV 753 Query: 739 TRKILRNGEVAPPKEDPVPLPE 760 N D + E Sbjct: 754 VAHCFENAHRVRVSADTCSVCE 775 >UniRef50_C1E9E3 DNA topoisomerase n=1 Tax=Micromonas sp. RCC299 RepID=C1E9E3_9CHLO Length = 1227 Score = 560 bits (1442), Expect = e-157, Method: Composition-based stats. Identities = 260/872 (29%), Positives = 393/872 (45%), Gaps = 139/872 (15%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LV+VESPAKA ++ KYLG Y V +S GH+RDL Sbjct: 135 KLVVVESPAKATSVQKYLGDGYTVLASYGHVRDLVQKNG--------------------- 173 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 GV P ++ + ++ VV ++ + A+ A + LATD DREGEAI+WH+ Sbjct: 174 --------GVKPEDDFAMLW-AEKARDGVVRDIVKNAKGAAELLLATDPDREGEAISWHI 224 Query: 124 REVIGGDDA-------RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 E++ RV F E+TK A+R+AF P E++ V+A ARR +D + G Sbjct: 225 VELLREKGVLGSSSSLPVKRVTFTEVTKKAVREAFESPREISAPLVDAYLARRALDYLFG 284 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS--GEAL 234 + +SP+LW+K+ LSAGRVQS A+RLV ERE EI+ FV EEFW V A G + Sbjct: 285 FTLSPVLWRKMPGALSAGRVQSAALRLVCEREFEIERFVKEEFWNVFAGLEPDGSSGRSF 344 Query: 235 ALQVTHQNDKPFRPVN-----KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTL 289 ++TH + K + + A L + +V + +K + +P PF TSTL Sbjct: 345 VGELTHLDGKRLGKMEPGSREAAELAARAVLSASSTLAVHDVVEKDVSRRPRPPFTTSTL 404 Query: 290 QQAASTRLGFGVKKTMMMAQRLYEA-----GYITYMRTDSTNLSQDAVNMVRGYISDNFG 344 QQ AS+RLGFG +TM AQ LYE G ITYMRTD ++S AV +R FG Sbjct: 405 QQDASSRLGFGAARTMAAAQSLYEGRGWGEGLITYMRTDGLHVSPAAVAELRDVAGAEFG 464 Query: 345 KKYLPESPNQYAS-KENSQEAHEAIRPSDVNVMAESLKDM---EADAQKLYQLIWRQFVA 400 ++Y+PE PN + ++N+QEAHEAIRP+ ++ +++ + +D +LY+LIW + +A Sbjct: 465 EEYVPEKPNFFRKVQKNAQEAHEAIRPTKAGILPQAVANRLGSGSDEARLYRLIWARTMA 524 Query: 401 CQMTPAKYDSTTLTVGAGDF--RLKARGRILRFDGWTKVMPA--------LRKGDEDRIL 450 QM+ A V + D RLKA G L F G+ GD DR L Sbjct: 525 SQMSAAVTKRVQADVWSEDERLRLKATGSRLIFPGYLAAYKHGMRDGDDSTSFGDNDRWL 584 Query: 451 PAVNKGDALTL---------------------------------------VELTPAQHFT 471 P ++ G+ + + +T QH+T Sbjct: 585 PRLDVGEKIRVIGDEVKIVERDKDAKRGGFKKADADDDGEHEIDTTAGKDTGVTATQHWT 644 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR--FYAEKMGEIVTDR 529 +PP R++E SLVK LE++GIGRPSTYA+I+ I+ RGYV E+ R E G +V+ Sbjct: 645 QPPGRYTEGSLVKALEEKGIGRPSTYATIMKVIKRRGYVAGESGRGPLIPETRGRLVSSF 704 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 L F E ++Y FTA +E+ LD +A+ + +WK+VL F+ F ++ + + Sbjct: 705 LAHFFDEYVDYGFTAGLEDRLDDIASGKEDWKSVLSGFWGPFAGDVESLKGIRTSQVVDV 764 Query: 590 NQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE 649 L + + R ++ + E Sbjct: 765 LDATLGAHFFGDDESSVDARLSAIER----------------AAEEAATQAESTGGYPTV 808 Query: 650 DAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGY----EIEEGEFRIKGYD 705 + L + RRCP CGT + C N P+C +G + Sbjct: 809 AFDPEELSSTRRCPGCGTGRLGLKLSRTGGFIGCSNYPSCGHTRQLVNDGDGAVGGGNFP 868 Query: 706 GPIVECEKCGSEMHLKMGRFGKYMACTNE-------ECKNTRKILRNGEVAPPKED---- 754 + + G ++ ++ G +G Y+ + K R L+N + P D Sbjct: 869 IELGTDPESGGDVAIQNGPYGPYIELQMPSSPDDSKKTKPQRFGLKNIGLKPEDVDMDLA 928 Query: 755 ----PVPLPELPCEKSDAYFVLRDGAAGVFLA 782 P+ P + V+ G G +++ Sbjct: 929 MTLLRYPMVLGPHPEDGKDVVMNMGPFGWYVS 960 Score = 44.7 bits (104), Expect = 0.017, Method: Composition-based stats. Identities = 8/54 (14%), Positives = 15/54 (27%), Gaps = 1/54 (1%) Query: 746 GEVAPPKEDPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRETRAPLVE 798 G + C L+ G F+ + +P TR + + Sbjct: 804 GYPTVAFDPEELSSTRRCPGCGTGRLGLKLSRTGGFIGCSNYPSCGHTRQLVND 857 >UniRef50_Q59046 DNA topoisomerase 1 n=9 Tax=Methanococcales RepID=TOP1_METJA Length = 761 Score = 559 bits (1441), Expect = e-157, Method: Composition-based stats. Identities = 204/844 (24%), Positives = 347/844 (41%), Gaps = 131/844 (15%) Query: 3 KALVIVESPAKAKTINKYLGS-------------------DYVVKSSVGHIRDLPTSGSA 43 AL+I E P+ AK I LG +V S+VGH+ L + Sbjct: 6 TALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLVEKEN- 64 Query: 44 AKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEA-HYEVLPGKE---KVVSELKQL 99 G P + + V GKE K + LK+L Sbjct: 65 -------------------------KEFGFYPVFDIKWVPASVDKGKEYVNKYIKALKKL 99 Query: 100 AEKADHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI 159 ++ AD Y+ATD D EGE I +H + G + R+ F+ +TK I +AF P E++ Sbjct: 100 SKDADEFYIATDWDIEGELIGYHALKYCCGREK-AKRMRFSSLTKKEIVRAFENPDEIDY 158 Query: 160 DRVNAQQARRFMDRVVGYMVSPLLWKKIA-----RGLSAGRVQSVAVRLVVEREREIKAF 214 V+A ++R +D G +S L I + +S GRVQ A+ + ERE EIK F Sbjct: 159 GLVDAGESRHILDWYFGINLSRALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKF 218 Query: 215 VPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKAR-YSVLERED 273 +P+ +W ++A + + N+++ + ++ + V+E + Sbjct: 219 IPKPYWVIEALLKDNLKAIH---------EKEKFWNEKEAKNVYEKIKDEKSAKVVEIKK 269 Query: 274 KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD--A 331 KP PF TLQ+ A + K+T +AQ+LYE I+Y RT S L +D Sbjct: 270 TKRKLKPLPPFDLGTLQREAYSYFKISPKETQEIAQKLYENALISYPRTSSQKLPKDRKY 329 Query: 332 VNMVRGYISDN--FGK--KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADA 387 + + I ++ +GK + + + + + AH AI D+ S K+ Sbjct: 330 LEDILNIIKNHPVYGKWAERILKENLKPVEGKKEDPAHPAIHIVDIPKEELSEKE----- 384 Query: 388 QKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED 447 +++Y LI R+ +A A+ + + + + K G +GW ++ + + + Sbjct: 385 KEIYDLIARRTLAAFWDNAEREYLNVKIDIKGEKFKLSGSRTVKEGWHEIYYFPKFDEIE 444 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 LP + K D + + ++T + T+PP R++ AS++KELEKRG+G +T A II + R Sbjct: 445 --LPPLKKNDIIKVEKITITRKETQPPKRYTVASIIKELEKRGLGTKATRAEIIDKLIKR 502 Query: 508 GYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 GYV +++ +G V + L+ E+++ T +E L+++ + + VLD Sbjct: 503 GYV-IDDGSLKVTDLGISVIETLKRFCPEIIDEKMTRDLEEKLEKIQFRKIKKDDVLDEA 561 Query: 568 FSDFTQQLDKAEKDPEEGGMR-------PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCS 620 + L++ +K E+ G+ N+ CP CG + + G F+GCS Sbjct: 562 EKRLRKILEEFKKKEEDIGIYLIKNLDATNKKAKIVGKCPKCGGDLILIRHKKGRFVGCS 621 Query: 621 GYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 Y C +L + + + C C + + Sbjct: 622 NY-----PECDVKYSLPDKGRIK-------------IPNKVCDACKSPILKIGDRE---- 659 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNT 739 +C N P C + C KCG+++ LK G +G + C+N +CK T Sbjct: 660 -ICIN-PECP--------LKQVEVKEEDRICPKCGAKLILKKGVYGAFYGCSNYPKCKYT 709 Query: 740 RKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEE 799 I + V C K V+R+G G F+ + +PK R T + E Sbjct: 710 EPINKKEVVGK------------CPKCGGDLVVREGKFGKFVGCSNYPKCRYTEKLKLNE 757 Query: 800 LYRF 803 Sbjct: 758 KEEK 761 >UniRef50_C6I107 DNA topoisomerase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6I107_9BACT Length = 739 Score = 555 bits (1429), Expect = e-156, Method: Composition-based stats. Identities = 160/758 (21%), Positives = 279/758 (36%), Gaps = 65/758 (8%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LVI E P+ A+ I +G +Y V ++ GHI +L + P + Sbjct: 2 KLVIAEKPSMARAIKDVVGREYEVTNAFGHILELAEPDAYLPA----------DVPVSIK 51 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 G + R P E + + + ++ +L +KAD + A D DREG+ + + Sbjct: 52 TGRKIWRACDLPILPAEWRQIPIRSSKDQLIKIGELLKKADLVVNAGDPDREGQLLIDEI 111 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQARRFMDRVVGYMVSP 181 + R RV + + K +I +AF + +A R D +VG ++ Sbjct: 112 LDHFR-YRGRVERVWLSALDKTSIDKAFRDLRDNRSYKPLSDAAMGRSRADWLVGMNLTR 170 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT-- 239 S GRVQ+ + LVV R+ I+ F +++EV A G AL Sbjct: 171 AATLSSGSFYSIGRVQTPTLALVVHRDLAIERFAARDYFEVRARIRHERGTFSALWKPSD 230 Query: 240 ---HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 D+ R ++ Q +A SL K + E K + P+ S LQ+AAS R Sbjct: 231 PSGPGFDEEGRLTDRRQAEAL-SLKGKGAGKISRYEKKEESKSAPLPYSLSALQKAASGR 289 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS----DNFGKKYLPESP 352 G + + Q LYE +Y RTD L + + + + + S Sbjct: 290 FGLSADEVLKTCQSLYEKKVTSYPRTDCRFLPVEQFSEAGRILQALPVSPDIRPLISASR 349 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTT 412 A AH AI P+ E D+ +K+Y +I ++A + +Y S Sbjct: 350 KHPAWNTAKVTAHPAIVPTG-----ERAGDLSEKERKIYDMIVSSYLALFLPDHRYFSAA 404 Query: 413 LTVGAGDFRLKARGRILRFDGWTKVMP-ALRKGDEDRILPAVNK---GDALTLVELTPAQ 468 L+V A GR GWT++ R+ + LP++ + G+A+ + Sbjct: 405 LSVEMNREIWTATGRQEIDPGWTRLFGRGDREEGGEEDLPSLPECRPGEAVLGEGGEVRE 464 Query: 469 HFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYASIISTIQDRGYVR 511 T+PP RF++ +L++ + E GIG +T A I+ T+ R Y+ Sbjct: 465 KKTRPPGRFTDGTLIEAMSNIHKFVEDPEAKQTLKETSGIGTEATRAGILETLVGREYIV 524 Query: 512 VENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 + ++ + + G + LE +L++ TA+ E+ L +V+ + +A + Sbjct: 525 RKGKQILSTEKGRSLVGFLEATLPDLVDPVTTARWEDDLSEVSAGKKRVEAFVGGIADLV 584 Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK--MGIRTASTGV---FLGCSGYALPP 626 +Q +GG+ + I CP CG + + R + F CS Sbjct: 585 REQTRTLLT-KGQGGLAGDPSSPAKIACPVCGGQALVTRRESRNKKGVFFWTCS-----Q 638 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNN 686 K ++ + + CP C + + C Sbjct: 639 KTAAGEPVHPPLTDVAGTPGAPFSEKPPLNSDGPPCPTCRKPLSAETTSKGTAYFRC--- 695 Query: 687 PTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGR 724 +G+ + G + K G+ Sbjct: 696 --AEGHGPWWSDNGSPGNPWKPQSGTESAKGSFKKSGK 731 >UniRef50_C7LTI8 DNA topoisomerase n=1 Tax=Desulfomicrobium baculatum DSM 4028 RepID=C7LTI8_DESBD Length = 620 Score = 554 bits (1428), Expect = e-156, Method: Composition-based stats. Identities = 152/620 (24%), Positives = 256/620 (41%), Gaps = 66/620 (10%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M + L+I E P+ A+ + LG ++V +VGH+ ++ Sbjct: 1 MPRTLIIAEKPSVARELAGVLGVKGRGDGFLQGPGHIVTWAVGHLVNIAEPAEQNPAW-- 58 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIY 107 + M P +LP K ++ + D + Sbjct: 59 ----------------SGRWSMRQLPMLPSRFTLGILPSTAKQYEIIRNFLLDDDIDSVV 102 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQ 165 ATD REGE I + ++ G R+ N++T+ +++AF GE + +A Sbjct: 103 NATDAGREGELIFRRIY-LLAGSTKPIKRLWANDMTEKGLQKAFAGMVSGEEKRNLGHAA 161 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D +VG S L + ++ GRVQ+ ++L+VER REI+ F+P ++W V+ Sbjct: 162 FARAEADWLVGMNFSRLFTLRAGSLITVGRVQTPVLKLLVERRREIENFLPRDYWTVEGE 221 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 A + K + E+ Q V +VLE E K KP F Sbjct: 222 FAHEGETFKATWFAAPDFKDSKIWQVEEGQTVVQACAGKDGAVLEMEKKKGRQKPPLLFD 281 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRGY------ 338 + LQ+ A++RLGF ++T+ +AQ LYE ITY RTDS L+++ Sbjct: 282 LTNLQKEANSRLGFSAQQTLSIAQDLYEKRKLITYPRTDSRYLTKELFAECLENMRAVYA 341 Query: 339 ----ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 IS + + H AI P+ + + + + +Y++I Sbjct: 342 HFPEISQSAAANIKDAKKKFECVNDKKVSDHHAIIPTTLR---ANPATLGKEEWAIYEMI 398 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVN 454 R+F A M A + S+TL +G R +A G+I + GW + P + ED LP + Sbjct: 399 CRRFAAAFMDDATFASSTLWIGVEGHRYRATGKIFQDKGWLEAEPW--RASEDNPLPNLR 456 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRPSTYA 498 KG A+T L H TKPPA F++A+L+ +E +RG+G P+T A Sbjct: 457 KGAAVTAQSLDLVAHKTKPPAHFTDATLLAAMETAGKLIDDEELRDAMKERGLGTPATRA 516 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 II T+ R Y+ + +R A +G D + ++ + + T + E L ++ Sbjct: 517 QIIETLLARKYIGKDGKRLVATDLGCWAVDVVCSMIPQVASPELTGEWEKRLKEMEQGGY 576 Query: 559 EWKAVLDHFFSDFTQQLDKA 578 + + + + + Sbjct: 577 AYGVFMHQVREMVSSGVSRV 596 >UniRef50_B4EXZ8 DNA topoisomerase n=4 Tax=Enterobacteriaceae RepID=B4EXZ8_PROMH Length = 684 Score = 553 bits (1426), Expect = e-156, Method: Composition-based stats. Identities = 167/695 (24%), Positives = 268/695 (38%), Gaps = 95/695 (13%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 L + E P++AK I + +G + V + GH+ + + + A Sbjct: 2 KLFLCEKPSQAKDIARVIGAHQRRDNFFQGNGVQVAWARGHLLEQAEPEAYGAQFAA--- 58 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 R P + V + +KQL +A + +ATD Sbjct: 59 ---------------PWRQSALPVIPEQWKMVVKKDAVSLFQTIKQLLSQATEVVIATDA 103 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRF 170 DREGE IA L E + R+ + + + +IRQA N PGE +A R Sbjct: 104 DREGEVIARELLEACH-YRKKVQRLWLSALDEASIRQALNNLLPGEKTASLYSAGLGRAR 162 Query: 171 MDRVVGYMVSPLLWKK-----IARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 D ++G ++ L K LS GRVQ+ + L+V REREI FV + FW V AS Sbjct: 163 ADWLIGMNMTRLFTLKARELGFGGILSVGRVQTPTLALIVRREREITHFVSKPFWRVTAS 222 Query: 226 TTTPSGEALALQVT--HQNDKPFRPVNKEQTQAAVSLLEKA-RYSVLEREDKPTTSKPGA 282 A D R ++ + QA L +A + +V + + P Sbjct: 223 LQHQGIIFQAHWRPASQYCDDEHRCIHVQAAQAVEQLCRQAGKATVCTVNETKGKALPPL 282 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISD 341 PF TLQQAAS R G+ K + +AQ LYE TY RTD L + + Sbjct: 283 PFDLGTLQQAASRRWGYSADKVLEIAQSLYEKHKATTYPRTDCGYLPVSMRADIPVVLDA 342 Query: 342 NFGKK--------YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 L + + AH AI P+ L M +Y+L Sbjct: 343 LSQSDPALQNVLAQLQPARISRVWNDAKITAHHAIIPTRQTP---DLNAMNEAELNVYKL 399 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------PALRKGDED 447 I ++A + ++D+T + + G + A+G++ R GW+ + P +++ E Sbjct: 400 IRAHYLAQFLPDQEWDATEVFLDIGGQQFVAKGKVERVKGWSVLFVKHEDDPPVKEEAET 459 Query: 448 ------RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL--------------- 486 LP++++G+ + E Q T PP +++ +L+ + Sbjct: 460 GLEAGTETLPSLHEGEFCVVQEAKVVQLATSPPKPYTDGTLIAAMKNASSFITDPTLKKV 519 Query: 487 --EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTA 544 E G+G +T A II+T+++R + + + A G + D L + TA Sbjct: 520 LKENAGLGTEATRAGIITTLENRKLIVRQKKTLRATDTGCQLIDALPAAC---TDPGMTA 576 Query: 545 QMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGR 604 E SL+QVA + S + K + P + P CP+C Sbjct: 577 LWEQSLEQVAQGNLSLDVFMQKQISWLAHLIKKGGEMPLALDLPPMP------SCPSCHG 630 Query: 605 KMGIRTASTGVFLGCSGYALPPKERCKTTINLVPE 639 KM +R +S G F C Y CK ++ L + Sbjct: 631 KMVLRESSKGRFWSCQRYP-----DCKGSVPLPEK 660 Score = 54.7 bits (130), Expect = 2e-05, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 18/39 (46%), Gaps = 1/39 (2%) Query: 763 CEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELY 801 C VLR+ + G F + +P + + PL E++ Sbjct: 625 CPSCHGKMVLRESSKGRFWSCQRYPDCKGSV-PLPEKMQ 662 >UniRef50_C7J0A2 DNA topoisomerase n=2 Tax=Magnoliophyta RepID=C7J0A2_ORYSJ Length = 928 Score = 552 bits (1422), Expect = e-155, Method: Composition-based stats. Identities = 169/855 (19%), Positives = 289/855 (33%), Gaps = 102/855 (11%) Query: 3 KALVIVESPAKAKTINKYLGSD------YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTA 56 + L + E P+ AK++ + L +S + + + ++ T Sbjct: 11 RVLNVAEKPSVAKSVAEILSRPSGGMRSREGRSRYNRVFEF-DYSIGGRACHMLVTSVTG 69 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHYE--VLPGKEKVVSELKQLAEKADHIYLATDLDR 114 + + DP + A V K+ + L++ A K + L D DR Sbjct: 70 HLMELEFDDRFRRWHSCDPADLFHAPVRKSVPQDKQDIKRTLEEEARKCQWLVLWLDCDR 129 Query: 115 EGEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 EGE IA+ + ++ G ++R R F+ + I +A N +A AR+ +D Sbjct: 130 EGENIAYEVIDICAGANSRLNIWRARFSALIDREIHEAVQHLDRPNKLFADAVDARQEID 189 Query: 173 RVVGYMVSPLLWKKIARG-------------LSAGRVQSVAVRLVVEREREIKAFVPEEF 219 +G + + LS G Q + +VER EI+A PEEF Sbjct: 190 LRIGASFTRFQTMLLKDAFVLDDTGDDRNIILSYGPCQFPTLGFIVERFWEIQAHEPEEF 249 Query: 220 WEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSK 279 W ++ S T+ G F + +E+ +V ++ Sbjct: 250 WTINCSHTSDEG---TASFGWIRGHLFDYSSAVVI--YEMCVEEPMATVQNVRNQEKLKY 304 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVNMVRG 337 P P T LQ+ AS + TM +A+ LY+AG+I+Y RT++ N S D ++V Sbjct: 305 PPYPLSTIELQKRASRYFRMSSEHTMKVAEELYQAGFISYPRTETDNFSPNTDLHSIVHE 364 Query: 338 YISDN----FGKKYLPES---PNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKL 390 ++ + ++ L ++ + +AH I P+ + + + +KL Sbjct: 365 QVAHPNWGTYAQRLLDPEARLWRNPSNGGHDDKAHPPIHPTKFSAGETNW---TDNHKKL 421 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRIL 450 Y+L+ R F+AC PA TT+ + + A GR++ + V G +L Sbjct: 422 YELVVRHFLACCSQPAVGAETTVEIDIAGEQFNASGRVVLAKNYLDVYRFDSWGG--TLL 479 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 P G LT T+PP +EA L+ ++K GIG +T I + DR Y Sbjct: 480 PTYIIGQQFVPTTLTLDSGMTRPPPLLAEADLLGCMDKAGIGTDATMHDHIKKLLDRCYA 539 Query: 511 RVE-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 + N RF +GE + +E EL + ME + V+ VL++ Sbjct: 540 TKDANTRFSPTNLGEALVMGYDEMGYELWKPYLRSMMEADMKSVSIGTKSKSEVLENCLQ 599 Query: 570 DFTQQLDKAEKDPEEGG--------------MRPNQMVLTSIDCPTCGR-KMGIRTASTG 614 A + + + T C C +M ++ TG Sbjct: 600 QMKACFLDARANKVKLFDAMGTFFARSSRPVNETQNSIETVRPCAACNESEMFLKQRPTG 659 Query: 615 VF-LGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYL 673 F +GC G+ +C+ + L + A + CP C + Sbjct: 660 EFMVGCRGFP-----QCRNVVWLPRSL------------SGAAVTDQVCPTCAPGPVYKI 702 Query: 674 IDPKRK----------LHVCGNNPTCDGYEIEEGEFRIKG----YDGPIVECEKCGSEMH 719 R+ C CD E E G P + S + Sbjct: 703 QFKFRRRDIPPNFDVDHLGCIGG--CDDILKELMELSRFGSHSQTATPARNQSQTASGVR 760 Query: 720 LKMGR---FGKYMACTNEECKNTRKILRNG-EVAPPKEDPVPLPELPCEKSDAYFVLRD- 774 R + T + G + ++ C VLR Sbjct: 761 QGSSRQDLHTSFHPAVQFTNGQTPVVNPQGFRSTHTQSSGNASGQVQCTSCREPCVLRTA 820 Query: 775 ----GAAGVFLAANT 785 F Sbjct: 821 NTEANRGRKFYKCQN 835 >UniRef50_C5Z4V5 DNA topoisomerase (Fragment) n=12 Tax=cellular organisms RepID=C5Z4V5_SORBI Length = 1094 Score = 550 bits (1418), Expect = e-155, Method: Composition-based stats. Identities = 235/793 (29%), Positives = 367/793 (46%), Gaps = 98/793 (12%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K++V+VES KAK I YLG Y V S GH+RDL Sbjct: 309 AKSVVVVESATKAKVIQNYLGDMYEVLPSYGHVRDLAGRSK------------------- 349 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 V P ++ +EV + +K + A+++ LA+D DREGEAIAW Sbjct: 350 ----------SVRPDDDFSMVWEVPAAAWTHLKSIKVALKGAENLILASDPDREGEAIAW 399 Query: 122 HLREVIG-----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 H++E++ G D +RV F+EIT++AI++A P +++D VNA ARR +D ++G Sbjct: 400 HIKEMLEQQGALGCDVTVARVAFHEITEDAIKKALMSPRYIDMDLVNAYLARRSLDYLIG 459 Query: 177 YMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT-----PSG 231 + +SPLLW+K+ SAGRVQS A+ LV +RE EI+ F P+E+W V P+G Sbjct: 460 FGISPLLWRKLPGCQSAGRVQSAALALVCDREAEIEQFKPQEYWTVQTYFKMHFADPPNG 519 Query: 232 EALALQVTHQNDKPFR---PVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 + ++ H N K ++E+ QA + +++ VL + P P+ITS+ Sbjct: 520 TYIPFRIKHLNSKKLDQLSIRSQEEAQAIEKRIHSSKFEVLGVKRSKIHKNPPMPYITSS 579 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYI 339 LQQ A+ +L F TM +AQ+LYE G ITY+RTD ++S A +R + Sbjct: 580 LQQDAANKLHFTAGYTMKIAQKLYEGINLSSEETTGLITYIRTDGFHVSDGAAEDIRSLV 639 Query: 340 SDNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQ 397 + +G+KY+ E +Y K +N+QEAHEAIRP+ + + SL ++ D+ KLY LIW++ Sbjct: 640 KERYGQKYVSEDTRKYLKKVKNAQEAHEAIRPTSIRRLPSSLVGILDDDSLKLYTLIWKR 699 Query: 398 FVACQMTPAKYDSTTLTVGA--GDFRLKARGRILRFDGWTKVMPALR------------- 442 +ACQM ++ + + +G G+ + L F G+ V Sbjct: 700 TMACQMEASRTEMIQVDIGTPEGEMIFHSVASKLDFKGYQAVYEDTEAIPCSDNSERDSV 759 Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIS 502 D L + D + V + QHFTKPP+R+SE +L+K+LE+ GIGRPSTYASI+ Sbjct: 760 DEDNFEALSKLMVKDLVFPVNVHLGQHFTKPPSRYSEGALIKKLEELGIGRPSTYASIMK 819 Query: 503 TIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKA 562 +QDR YV ++R + E G +V+ L +F E+ +Y FTA ME LD V+ EWK Sbjct: 820 VLQDRKYVTAKSRVLHPEFRGRMVSAFLLHHFSEVADYSFTANMETELDNVSAGSTEWKG 879 Query: 563 VLDHFFSDFTQQLDKAEKDPEEGGMR----------PNQMVLTSIDCPTCGRK-MGIRTA 611 +L ++ F + A K R + S CP+C + + + Sbjct: 880 LLKDYWERFNKYCADASKLDGRKVERMLEEKFGPILFPDVDKDSRICPSCSEGTLRFKVS 939 Query: 612 ST--GVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKC---- 665 G F+GC + +CK + + E E ++ R P Sbjct: 940 RYGEGYFIGCDRHP-----KCKYIARSLSQQEDETEPTEESPKSFTPRLLGVMPDSDQKV 994 Query: 666 -------GTAMDSYLIDPKRKLHVCGNNP-TCDGYEIEEGEFRIKGYDGPIVECEKCGSE 717 G + + E + Y + + + Sbjct: 995 FLKQGPYGYYVQIGEDKKGLFPKRASLSEVKDIDSVTLEDAIELLQYPKILGKHPEDDHP 1054 Query: 718 MHLKMGRFGKYMA 730 + + + G + Sbjct: 1055 VLITHSKVGYNIK 1067 >UniRef50_D2VSX3 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2VSX3_NAEGR Length = 1015 Score = 550 bits (1418), Expect = e-155, Method: Composition-based stats. Identities = 166/809 (20%), Positives = 289/809 (35%), Gaps = 69/809 (8%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 K L + E P AK I L + KS I + S ++ Sbjct: 23 KVLCVAEKPEAAKQIATILSAGKFQRREGKSKFNKIFEF-EYRMNGVVVTMSVTSVLGHL 81 Query: 59 PKKDERGALVNRMGVDPWHNWEAHY----EVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 + L + DP + V ++ L+Q A A + L D DR Sbjct: 82 MELGFDPKLKSWTSCDPITLMDPATPVFRNVPEKNLEIQQNLEQEARYATKLLLWLDCDR 141 Query: 115 EGEAIAWHLREVIGGDDAR-------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQA 167 EGE IA+ + EV + R F+E T AI +A N+ A Sbjct: 142 EGENIAFEVIEVCKKVNRSLSIENDSILRARFSEFTAAAINRAIRNLERPNVLDSMAVDT 201 Query: 168 RRFMDRVVGYMVSPLLWKKIARG--------LSAGRVQSVAVRLVVEREREIKAFVPEEF 219 R+ +D +G + ++ + +S G Q + VV+R+ IK F E F Sbjct: 202 RQELDLRIGASFTRFQSLRLKKKFQGITADYISYGPCQFPTLGFVVKRDLIIKNFESESF 261 Query: 220 WEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSK 279 W ++ + GE Q + + F + +E R V+ E K Sbjct: 262 WTLNCTH--DMGEEGKAQFLWKRGRLFDQLTCLVIYEL--CVEAQRARVVNVEKKRRYKY 317 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYI 339 P T LQ+ AS +L G +TM +A+ LY G+I+Y RT++ N +Q + ++ + Sbjct: 318 RPDPLNTIELQKLASQKLKMGSHETMKVAESLYNKGFISYPRTETNNYNQFQDDDLKRLV 377 Query: 340 SDN--------FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLY 391 +++ + L + S + +AH I P + ++ Q LY Sbjct: 378 NEHTSNPTWGGYASDLLNGGYQKPPSGKQDDKAHPPIHP-----LKGDCNSNDSKEQALY 432 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILP 451 +LI R F+AC A T + + + G ++ + ++ R D + +P Sbjct: 433 ELIARHFLACCSKDAVGAETKVIISIANEEFTCSGLMVEQKNFLEIWKYDRWSD--KSIP 490 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR 511 N G L T+PP SE+ L+ ++ GIG +T A I TIQ+RGYV Sbjct: 491 VFNAGQEFIPTSLLMDHGETRPPPHLSESDLISAMDSNGIGTDATVAQHIKTIQERGYVI 550 Query: 512 VENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 + RF A +G + + EL + ++ME + ++ E +AV+ S + Sbjct: 551 KKGNRFEATNLGMALLQGYDLIGYELSTPNLRSKMEKDMLSISKGEQSKEAVIHQSLSMY 610 Query: 572 TQQLDKAEKDPEEGGMRPNQMVLT-----------SIDCPTCGRKMGIRTASTGVFLGCS 620 + K Q T +C M ++ FL C Sbjct: 611 KHVYIQICKSAYLLDKAVQQHFPTLGEGQSRVLGRGFSLCSCKNPMDLKEQDGNNFLHCK 670 Query: 621 GYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 + K+ + + + + + T + + CP C + Sbjct: 671 NCSDSYPLPSKSEYESIEDVCPICNFQILNIITQKNTSYKLCPHCFNNPPEIENSNESFA 730 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK--YMACTN-EECK 737 + C G + D + +C+KC + + ++ + Y+ C CK Sbjct: 731 NGF----KCFNCTFT-GCKYSRKKDAVVRKCQKCSNNLVVRQRKNDTSLYIGCKGFPNCK 785 Query: 738 NTRKILRNGEVAPPKEDPVPLPELPCEKS 766 + + ++ E A L C + Sbjct: 786 SAVWLPKSIEKA-------DLTTEKCNRC 807 >UniRef50_B7I2H2 DNA topoisomerase n=4 Tax=Proteobacteria RepID=B7I2H2_ACIB5 Length = 672 Score = 550 bits (1416), Expect = e-154, Method: Composition-based stats. Identities = 236/723 (32%), Positives = 332/723 (45%), Gaps = 81/723 (11%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 LVIVESP K K I+ LG+ Y V +SVGH+RDLP Sbjct: 2 TTLVIVESPGKVKKISALLGAGYKVVASVGHVRDLPPKE--------------------- 40 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +G++P ++ HY+ V++ LK+ AD I LATD DREGEAIAWH Sbjct: 41 --------LGIEP-PDFRPHYQPTERGRDVLARLKKDVAAADRILLATDPDREGEAIAWH 91 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 L + + D R+ F ITK+ ++ A P ++++RV +Q+ARR +DR+VGY VSP Sbjct: 92 LADALKLRDP--QRITFTAITKDKVQAAVAAPRRIDMNRVRSQEARRALDRIVGYRVSPA 149 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQN 242 L + + LSAGRVQS AVRLVV+REREI +F E + + + G A + Sbjct: 150 LSDRAGQPLSAGRVQSPAVRLVVDREREIASFKVTEHYGAELTFDNGDGTAWRAVWDTKP 209 Query: 243 DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVK 302 A+ + +V E D P APF TSTLQQAA RL K Sbjct: 210 HMAEGESYIMDDALALRVAAVRHVTVAEVADTEKGRAPAAPFTTSTLQQAAGQRLKLRPK 269 Query: 303 KTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQ 362 KTM +AQRLYE G ITY RTD+ N+ + + Y L E P ++ +KE +Q Sbjct: 270 KTMELAQRLYEQGAITYHRTDAPNMDDAGMEDIAAYARS--AGLPLAEKPRRWKAKEGAQ 327 Query: 363 EAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF-- 420 E HEAIRP+ + D + LY+LIW++ VA Q+ A Y ++ + Sbjct: 328 EGHEAIRPTHAADLEAGE---TDDEKALYRLIWQRAVASQLADAIYAVRSVRLAGDAEGL 384 Query: 421 --RLKARGRILRFDGWTKVM------PALRKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 A GR L+ GW V + +PA+ +G LT TK Sbjct: 385 AVAFTATGRTLQSPGWMAVYAADADDSDDEGEASNNPIPALAEGAGLTASSGRLLTKHTK 444 Query: 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV-RVENRRFYAEKMGEIVTDRLE 531 PP RF+EA+LVKE+E+ GIGRPSTYA+II I RGYV + +GE + D L Sbjct: 445 PPTRFTEATLVKEMERLGIGRPSTYAAIIENITGRGYVIEGQKGYLTPSPIGETIRDALV 504 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 F D+T +E+ LDQ+A +A+++ V+ +S +L K + Sbjct: 505 GRF-RFAELDYTRGLEDELDQIAEAKADYQGVISAAWSALDDELGKLDS----------A 553 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDA 651 + + CP CG+ + R G F C+GY CKT++ + Sbjct: 554 GIAAAHPCPACGKALHRRKGQYGFFWSCTGYP-----ECKTSLPDDKG-------KPGQR 601 Query: 652 ETNALRAKRRCPKCGTAM-----DSYLIDPKRK-----LHVCGNNPTCDGYEIEEGEFRI 701 + +CPKCG + S K + C P CD + + Sbjct: 602 KAPPPSTGFQCPKCGKELARRQGVSKPKKKGMKGRPYDFYSCTGYPKCDASYQTGPDGKP 661 Query: 702 KGY 704 Sbjct: 662 VFE 664 Score = 72.8 bits (177), Expect = 5e-11, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 35/102 (34%), Gaps = 14/102 (13%) Query: 709 VECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD 767 C CG +H + G++G + +CT ECK + + ++ P P C K Sbjct: 559 HPCPACGKALHRRKGQYGFFWSCTGYPECKTSLPDDKGKP--GQRKAPPPSTGFQCPKCG 616 Query: 768 AYFVLRDG-----AAG------VFLAANTFPKSRETRAPLVE 798 R G G F + +PK + + Sbjct: 617 KELARRQGVSKPKKKGMKGRPYDFYSCTGYPKCDASYQTGPD 658 Score = 59.0 bits (141), Expect = 7e-07, Method: Composition-based stats. Identities = 21/126 (16%), Positives = 37/126 (29%), Gaps = 16/126 (12%) Query: 647 EGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE---EGEFRIKG 703 E ++ + A CP CG A+ C P C + + R Sbjct: 546 ELGKLDSAGIAAAHPCPACGKAL-HRRKGQYGFFWSCTGYPECKTSLPDDKGKPGQRKAP 604 Query: 704 YDGPIVECEKCGSEMHLKMGRFGK-----------YMACTN-EECKNTRKILRNGEVAPP 751 +C KCG E+ + G + +CT +C + + +G+ Sbjct: 605 PPSTGFQCPKCGKELARRQGVSKPKKKGMKGRPYDFYSCTGYPKCDASYQTGPDGKPVFE 664 Query: 752 KEDPVP 757 Sbjct: 665 GAGQQA 670 Score = 54.7 bits (130), Expect = 2e-05, Method: Composition-based stats. Identities = 12/78 (15%), Positives = 23/78 (29%), Gaps = 7/78 (8%) Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLR 812 + PC R G G F + +P+ + + + + + P Sbjct: 551 DSAGIAAAHPCPACGKALHRRKGQYGFFWSCTGYPECKTSLPDDKGKPGQRKAPPP---- 606 Query: 813 YLADAPQQDPEGNKTMVR 830 Q P+ K + R Sbjct: 607 ---STGFQCPKCGKELAR 621 >UniRef50_Q9LVP1 DNA topoisomerase n=6 Tax=Embryophyta RepID=Q9LVP1_ARATH Length = 926 Score = 549 bits (1415), Expect = e-154, Method: Composition-based stats. Identities = 161/851 (18%), Positives = 274/851 (32%), Gaps = 99/851 (11%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 L + E P+ AK++ L +S I + + + TS Sbjct: 10 TVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRMLMTSV-IGHL 68 Query: 59 PKKDERGALVNRMGVDPWHNWEAHY--EVLPGKEKVVSELKQLAEKADHIYLATDLDREG 116 + + DP ++A V K+ + L++ A K+D + L D DREG Sbjct: 69 MELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVLWLDCDREG 128 Query: 117 EAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E IA+ + +V R F+ + I +A + N A AR+ +D Sbjct: 129 ENIAFEVVDVCRAVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVDARQEIDLR 188 Query: 175 VGYMVSPLLWKKIA-------------RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 +G + + R +S G Q + +VER EI+A PEEFW Sbjct: 189 IGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQAHEPEEFWT 248 Query: 222 VDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED-KPTTSKP 280 ++ S + G F +E+ +V+ + P Sbjct: 249 INCSHQSEEG---LATFNWMRGHLFDY--ASAVILYEMCVEEPTATVMNVPHPRERFKYP 303 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD------AVNM 334 P T L++ AS + TM +A+ LY+AG+I+Y RT++ + S Sbjct: 304 PYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAGFISYPRTETDSFSSRTDLRAMVEEQ 363 Query: 335 VRGYISDNFGKKYLPESP---NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLY 391 R ++ ++ L A+ + +AH I P+ + + D +Y Sbjct: 364 TRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHPPIHPTKFSSGESNW---SRDHLNVY 420 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILP 451 +L+ R ++AC PA TT+ + R A GR + + +V G ++P Sbjct: 421 ELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVYRFESWGG--SVIP 478 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR 511 KG LT T+PP EA L+ ++K GIG +T I + DRGY Sbjct: 479 VYEKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGYAT 538 Query: 512 VE-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 + N RF +GE + ++ EL + A ME+ +++V+ VL+ Sbjct: 539 KDANTRFSPTNLGEALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKTKAEVLETCLQQ 598 Query: 571 FTQQLDKAE------------KDPEEGGMRPNQMVLTSIDCPTCG----RKMGIRTASTG 614 A ++ C M +R G Sbjct: 599 MKACFLDARVKKSKLLEAMTIFFERSNNTDESESQTAGEVVRRCNLCNESDMALRKNRDG 658 Query: 615 VF-LGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYL 673 F +GC Y +C+ + L A C CG + Sbjct: 659 NFMVGCMNYP-----QCRNAVWLP------------GPTLEASVTTNVCQSCGPGPVYKI 701 Query: 674 IDPKRK----------LHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMG 723 + R+ C ++ + + + Sbjct: 702 LFKFRQIGIPPGFDVNHLGCVGGCDDILKQLIDICGTGSRSQARRTPGTAPSNNIQGSNT 761 Query: 724 R-FGKYMACTNE-----ECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRD--- 774 R + C C + RN + C + VLR Sbjct: 762 RQSNVCIHCQQRGHASTNCPSRVPASRNSRPTATNPRNDES-TVSCNTCGSQCVLRTANT 820 Query: 775 --GAAGVFLAA 783 F + Sbjct: 821 EANRGRQFFSC 831 >UniRef50_C6NY48 DNA topoisomerase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NY48_9GAMM Length = 776 Score = 549 bits (1414), Expect = e-154, Method: Composition-based stats. Identities = 168/743 (22%), Positives = 284/743 (38%), Gaps = 75/743 (10%) Query: 3 KALVIVESPAKAKTINKYLG---SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKP 59 +VI E P+ A+ I + LG + Y + ++ GHI + + Sbjct: 2 TTVVIAEKPSMARAIREGLGPQANRYEITNAFGHILEQAEPDAY-----------LPGDV 50 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 K +G + RM P E + ++++ L + AD + A D DREG+ + Sbjct: 51 PKTAKGKKIWRMQDLPILPAEWKKFPKRDAKDQLAKIGALLKSADTVINAGDPDREGQLL 110 Query: 120 AWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQQARRFMDRVVGY 177 + E + RV + +R+AF E +A +AR D VVG Sbjct: 111 IDEILEHFH-YRGKVLRVWLKALDAENVRKAFAALESNEKYRPLKDAAEARSQSDWVVGM 169 Query: 178 MVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 ++ + K S GRVQ+ + +VV R+ EI+ FVP +++EV A G LA Sbjct: 170 NLTRAVTVKSGDLFSIGRVQTPTLAIVVRRDLEIENFVPRDYFEVFAQCRHTQGAFLAKW 229 Query: 238 VT-----HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 D+ R ++K +A + A V E K P+ S LQ+ Sbjct: 230 EPSSTDGPGFDEEGRLIDKRLAEAVAQKAKGA-GKVARFEAKEQKQSAPLPYSLSALQKV 288 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD----NFGKKYL 348 AS+R G ++ + Q LYE +Y RTD L ++ + + + + L Sbjct: 289 ASSRFGMSAQQVLDTCQSLYEKKITSYPRTDCRYLPEEQLVDAPRILGKLPIPDGIRPLL 348 Query: 349 PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKY 408 A AH AI P+ E + + KLY LIWR +VA + +Y Sbjct: 349 NPRQKHVAWNNAKITAHNAIVPTG-----EPARGLSDAEAKLYDLIWRSYVALFLPDYRY 403 Query: 409 DSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED------RILPAVNKGDALTLV 462 + + T+ G KA GR GW K+ A D++ LP + GD + Sbjct: 404 RALSATIALGGESWKATGRQDIDLGWKKLFGAQALEDDEDADGGKAPLPVMQTGDPVQGD 463 Query: 463 ELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYASIISTIQ 505 TKPPARF++ SL+ + E G+G +T AS++ T+ Sbjct: 464 GGKVEARQTKPPARFTDGSLIDAMSNIHKFVTDPQAKAKLKETSGLGTEATRASVLETLL 523 Query: 506 DRGYVRVENRRFYAEKMGEIVTDRLEE-NFRELMNYDFTAQMENSLDQVANHEAEWKAVL 564 R Y++ + ++ + G + LE+ + TA+ E+ L VA + + Sbjct: 524 QREYLQKKGKQLISTPKGRALIAYLEKQRLGSFADPVTTARWEDVLGMVAEGKVPMQKFT 583 Query: 565 DHFFSDFTQQLDKAEKDPEEG-GMRPNQMVLTSIDCPTCG-----RKMGIRTASTGVFLG 618 + + ++ + G +Q L + CP CG R++ + F Sbjct: 584 AAVTQEVAKAIEVLKSGSAMAGGGSSSQQPLRAQPCPICGGDAVVRRLQSKKNRKVFFWS 643 Query: 619 CSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKC-GTAMDSYLIDPK 677 CS + L+ ++ + + ++ CP C GTA + Sbjct: 644 CSN---------RDAHPLLQDDNGKPDKPFAERKEDSGPPGPECPHCAGTATRTKTTSTG 694 Query: 678 RKLHVCGNNPTCDGYEIEEGEFR 700 + + C P+C + E Sbjct: 695 KTYYRC---PSCQAAFWPDREDP 714 >UniRef50_Q185E5 DNA topoisomerase n=10 Tax=Clostridiales RepID=Q185E5_CLOD6 Length = 706 Score = 548 bits (1413), Expect = e-154, Method: Composition-based stats. Identities = 155/737 (21%), Positives = 271/737 (36%), Gaps = 81/737 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSD-----------YVVKSSVGHIRDLPTSGSAAKKSAD 49 MGK LV+ E P+ + I K LGS YV+ ++GH+ L S ++ Sbjct: 1 MGKILVLAEKPSVGRDIAKVLGSKNEKNGYIEGPKYVITWALGHLVTLADPESYGERYKS 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK--ADHIY 107 + PK V+ K + +K + D I Sbjct: 61 WSLEDLPILPKHL-------------------KTVVIKKSGKQFNTVKSQMNRNDIDEIV 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQ 165 +ATD REGE +A + E R+ + T AI+ F K + + + Sbjct: 102 IATDAGREGELVARWIIEK-SQVKKPIKRLWISSSTDKAIKDGFAKLKSGKEYENLYYSA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D ++G + L K LS GRVQ+ + ++++RE EI+ F P+E++ ++ Sbjct: 161 IARAEADWIIGINATRALTTKYNAQLSCGRVQTPTLAMLLKREEEIRNFKPKEYYGLELI 220 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 T + + + N+ +KE+ ++ + ++ + E A + Sbjct: 221 ATKGNSDIKFIWNDKNNNS--STFSKEKIESTLKKVKGVDIKISEVNKSYKKKYSPALYD 278 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYISDNFG 344 + LQ+ A+ GF K+T+ + Q+LYE + TY RTDS L+ D V ++ I Sbjct: 279 LTELQRDANKMFGFSAKETLSIMQKLYEHHKVLTYPRTDSRYLTSDIVGTLKDRIKAVNI 338 Query: 345 KKYL---------PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 Y N+ + H AI P++ V + D +K+Y L+ Sbjct: 339 SDYSKICNRLLKSNIIANKSFVDNSKVTDHHAIIPTEQKVF---MSDFSDKERKIYNLVV 395 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNK 455 ++F+A P +Y+ TT++ KA+G + GW + + DE +P V + Sbjct: 396 KRFLAVLSPPFEYEQTTISATVEGEIFKAKGNKVINLGWKESYKDIEDEDEYESIPNVLE 455 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR 515 D L + L T PP +E +L+ +EK G+G +T A II + + + +N+ Sbjct: 456 KDVLKVKGLKITSGKTNPPPYLNEGTLLTAMEKNGLGTVATRADIIEKLFNSFLMEKKNK 515 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 Y G + D + +L + TA E L ++ + ++ + Sbjct: 516 DIYITSKGRQLLDLVP---VDLKTPELTASWEKKLLDISKGKLSKNTFINDMKDYSKDIV 572 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 + + + LT CP CG+ M G L C Sbjct: 573 LEV----KNSDNKFKHDNLTKNRCPECGKFMLEVNGKKGKMLIC---------------- 612 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE 695 E +T + RCP C ++ R + Sbjct: 613 --------EDRECNTRKTISQVTNSRCPNCHKKLELRGEGEGRIFTCSCGYREKLSSFNK 664 Query: 696 EGEFRIKGYDGPIVECE 712 + + V Sbjct: 665 RKQEEKQKASKKDVNQY 681 Score = 56.3 bits (134), Expect = 5e-06, Method: Composition-based stats. Identities = 19/127 (14%), Positives = 39/127 (30%), Gaps = 17/127 (13%) Query: 685 NNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILR 744 + E++ + + K + C +CG M G+ GK + C + EC Sbjct: 566 DYSKDIVLEVKNSDNKFKHDNLTKNRCPECGKFMLEVNGKKGKMLICEDRECN------- 618 Query: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAAN-TFPKSRETRAPLVEELYRF 803 ++ + C LR G + + RE + + Sbjct: 619 ------TRKTISQVTNSRCPNCHKKLELRGEGEGRIFTCSCGY---REKLSSFNKRKQEE 669 Query: 804 RDRLPEK 810 + + +K Sbjct: 670 KQKASKK 676 >UniRef50_C4NUW5 DNA topoisomerase n=12 Tax=Gammaproteobacteria RepID=C4NUW5_ECOLX Length = 730 Score = 548 bits (1413), Expect = e-154, Method: Composition-based stats. Identities = 167/766 (21%), Positives = 270/766 (35%), Gaps = 112/766 (14%) Query: 5 LVIVESPAKAKTINKYL------------GSDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 L I E P++AK + + G + V+ + GH+ +L ++ + Sbjct: 3 LYICEKPSQAKDLAGVMKASQRGDGFLHDGGNRVITWAFGHLLELYMPDDYDERYKSWS- 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P Y V K ++ L +KA IY++TD Sbjct: 62 ------------------LETLPIAPESWRYNVRKSAFKQYKIVEGLVKKASTIYISTDY 103 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 DREGEAIA L + RV + +++I++A N + + A AR+ Sbjct: 104 DREGEAIARSLLDRFR-YSGPIRRVCLTALDESSIKKALNNVKDGKDTVSLYYAALARQR 162 Query: 171 MDRVVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 D +VG VS L L GRV + V LV +R+REI F P +W + + Sbjct: 163 ADWLVGMNVSRLYTVLARDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVN 222 Query: 226 TTTPSGEALALQVTHQN--DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 + +G+ A + + D+ R VNK + S + A + + E KP P Sbjct: 223 VSVQNGQFAAQWIPPEECSDEQGRCVNKAYAEQVASQVNGANAVISKAETKPGKESAPLP 282 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDN 342 F ++LQQ AS R G+ ++ + AQ LYE TY RTDS L + + + Sbjct: 283 FDLTSLQQYASKRWGYTAQQVLDAAQALYETHKATTYPRTDSRYLPESQKEDIPDILQAL 342 Query: 343 FGKKY--------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 + AH AI P+ + M LY I Sbjct: 343 ILSDQNVSGLVAGADPHRKARVFNDAKVTAHHAIIPT---PARTDISAMSEIEFNLYDAI 399 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD--------- 445 R ++A + ++ T++ V G + G+ GW + + + Sbjct: 400 RRFYIAQFYSEFEFTKTSIEVQCGRHLFASAGKTPTKQGWKVLFASDSESSPKDEGEDTD 459 Query: 446 ---EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK-------------- 488 E LP V++G+ L A T+P F+EA+L+ +E Sbjct: 460 APVEQEKLPRVSQGEPALLNGAELANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQIL 519 Query: 489 ---RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQ 545 G+G P+T ASII D+GY + + + A + L + + TA Sbjct: 520 KDTAGLGTPATRASIIQGAVDKGYFKRQKKVLLATDKAHALIAVLP---PAIKSPGMTAA 576 Query: 546 MENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE-------KDPEEGGMRPNQMVLTSID 598 E L++VA+ + + Q +++ + K+ S + Sbjct: 577 WEQELEKVASGSGNMSVFMKQISTWICQMVEQLKVAAPVLTKEGGAMAKAFEGAKPPSHE 636 Query: 599 CPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRA 658 C CG +M G F GC E CK T + + + Sbjct: 637 CFNCGGEMHRIKGKNGFFWGCQN------EACKKTFPDNRGKPEKRIAAEDCPD------ 684 Query: 659 KRRCPKCGTAMDSYL-----IDPKRKLHVCGNNPTCDGYEIEEGEF 699 CP CG+ M K C P C G + Sbjct: 685 ---CPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGTMPFKKSD 727 Score = 54.3 bits (129), Expect = 2e-05, Method: Composition-based stats. Identities = 14/104 (13%), Positives = 26/104 (25%), Gaps = 14/104 (13%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRF 803 + G + P C G G F ++T + + Sbjct: 618 KEGGAMAKAFEGAKPPSHECFNCGGEMHRIKGKNGFFWGCQN-EACKKT---FPDNRGK- 672 Query: 804 RDRLPEKLRYLADAPQQDPEGNKTMVRFSRK-----TKQQYVSS 842 PEK D P G+ +R + + + + Sbjct: 673 ----PEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCT 712 >UniRef50_C8VXL1 DNA topoisomerase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8VXL1_DESAS Length = 746 Score = 548 bits (1411), Expect = e-154, Method: Composition-based stats. Identities = 157/774 (20%), Positives = 281/774 (36%), Gaps = 140/774 (18%) Query: 3 KALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADST 51 K LV+ E P+ A+ ++ LG+ Y++ ++GH+ L Sbjct: 2 KQLVLAEKPSVARDLSNVLGNFNKGNGYLESDAYIITWAIGHLVTLAEPDDYDAALKKWF 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADH--IYLA 109 + P E + + K + +K L + D I A Sbjct: 62 -------------------LNTLPILPREFKLKPVSATLKQFNIVKSLLHRNDVGDIICA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI--DRVNAQQA 167 TD REGE I ++ ++ + R+ +E T A+R+ F+ N A +A Sbjct: 103 TDSGREGELIFRYIYKLTDC-QKPFKRLWLSETTPAAVRKGFDNLRPGNDLDRLAFAAEA 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D ++G + K + LS GRVQ+ + L+V RE+EI+AFVPE++WE+ A T Sbjct: 162 RSQADWLIGINATRAFTVKHNQLLSVGRVQTPTLALIVNREQEIRAFVPEKYWELFALFT 221 Query: 228 TPSGEALALQVTHQNDKPFRPVN------------------------------------- 250 +G+ + + K Sbjct: 222 KENGQTYIGKWFKKEKKAVENWEIPIQVGQKQTNQNPAASFEAAQGGIPSVMGEAVPSSN 281 Query: 251 --------------KEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 +E + + V+ E K P F + LQ+ A+ + Sbjct: 282 GQDKPVAMQTKFAAREAARDIQKKVTGQPGQVVSVEKKDIIEHPPLLFNLNDLQKEANKK 341 Query: 297 LGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGYI--------SDNFGKKY 347 G KT+ +AQ LYE ITY RTDS ++ + + + +NF Sbjct: 342 FGLSAAKTLSVAQELYESRKLITYPRTDSRCITVEMGKTIPQRLGALAVVAEYENFIHLI 401 Query: 348 LPES--PNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTP 405 N+ ++ H A+ P++V L + +D +++Y L+ R+F+A P Sbjct: 402 KERKAFLNKRYINDSKVTDHTALIPTNV---KPDLDKLSSDERRVYDLVVRRFLAAFFPP 458 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRK---GDEDRILPAVNKGDALTLV 462 A+Y+ T + +RGR+ GW V ++ DE ILP + +++ Sbjct: 459 ARYEQTQVITEVKQETFLSRGRVELDKGWKTVYDPVQDKLVDDEQGILPVIENEESVLTT 518 Query: 463 ELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRPSTYASIISTIQD 506 + + T PP R++EA+L+ +E G+G P+T A+II + Sbjct: 519 KTDIKEKKTNPPKRYTEAALLSVMEGAGRLLNDEELKEAMRGSGLGTPATRAAIIERLLK 578 Query: 507 RGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 GY+ + + GE + + E ++ + + TA+ E +L + + + + Sbjct: 579 VGYIERRKKTLLPTEKGENLIKLVPE---QVKSPEMTARWEKALADIEDGQLNPGEFMSG 635 Query: 567 FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPP 626 Q ++ A + + G CP CGR + CS Y Sbjct: 636 IIEQTRQVVELARRQ-KTEGEPLRNNRDIIGKCPLCGRPVVE----YPKSYSCSDY---- 686 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 + C+ I V + + V K+ ++ +K Sbjct: 687 RAGCQFVIWKVILGKNITVEMARILLEKGRLEKQP---------GFISKNGKKF 731 >UniRef50_A1AXT2 DNA topoisomerase I n=3 Tax=Bacteria RepID=A1AXT2_RUTMC Length = 777 Score = 547 bits (1409), Expect = e-154, Method: Composition-based stats. Identities = 254/803 (31%), Positives = 391/803 (48%), Gaps = 85/803 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K LVIVESPAKAKTI K+LG + VKSS+GHIRD+P Sbjct: 1 MEKNLVIVESPAKAKTIEKFLGKGFSVKSSIGHIRDMP---------------------- 38 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 MG+D +N+ YE+ K+KVV++L++ + A+ +YLATD DREGEAIA Sbjct: 39 -------KKNMGIDIENNFAPTYEITTDKKKVVADLRKAVKAAEKVYLATDEDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E + R+VF+EIT++AI A +P ++ V+AQQARR +DR+VG+ +S Sbjct: 92 WHLLEALNLP-KDTPRIVFHEITESAITHAIVEPRTVDYQLVDAQQARRIIDRLVGFEIS 150 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW+KI+ SAGRVQS +RLVVEREREI + ++V A T+ G ++++ Sbjct: 151 PVLWRKISGARSAGRVQSPVMRLVVEREREISQHITNSTYKVKAELTSEGGGLFEVKLSK 210 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + + ++ ++ A +V E K P PFITSTLQQ AS +LGF Sbjct: 211 EFESKKKVLD------FINAFLSANLTVTSIEKKSYKRSPKPPFITSTLQQEASQKLGFS 264 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 VK+TM +AQ LY G+ITYMRTDS LS+ A+++ I FG +Y + Sbjct: 265 VKQTMTLAQNLYREGFITYMRTDSFTLSEIAIDVTGQIIVKEFGSEY-HHIRRYKTKDTS 323 Query: 361 SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG-- 418 +Q+AHEAIRP+ N+ S+ +E A KLY LI+++ +ACQM+ A+ T + + Sbjct: 324 AQKAHEAIRPT--NLTKPSIFGIEDQAAKLYSLIYKRTLACQMSDAQLQKTQIKINISGL 381 Query: 419 DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFS 478 D + A IL F G+ +V E+++LP +NK D L+L + F++ R++ Sbjct: 382 DEKFLANDEILTFPGFLRVYDY--FSSENKLLPDLNKEDMLSLASFKARESFSRAKPRYT 439 Query: 479 EASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-------------------------- 512 EASLVK++E+ GIGRPST+A+++ST+QDR YV Sbjct: 440 EASLVKKIEEMGIGRPSTFATMVSTVQDRNYVTKETREGVERGYQLIEIKDNQIIQSQPS 499 Query: 513 -----ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 E + + + ++TD L + F +++Y+FTA++EN D +A W+ V+ +F Sbjct: 500 EVTGAEKNKLFPTNVAYLLTDFLVKYFNNIIDYEFTAKLENDFDAIATQNISWQGVVKNF 559 Query: 568 FSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPK 627 ++ F ++++ A + P G+ + +R G F K Sbjct: 560 YTPFHKKIEDAAD----ISREETHGMRELGTDPKSGKLVSVRFGRYGAFAQIGHKDDEDK 615 Query: 628 ERCKTTINLVPEN-----EVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHV 682 + + + E L + G D K Sbjct: 616 PIFASLRDSLDIESITLDEALELFNMPRTVGETDDFGTIKANYGRFGPYIEYDKKYVSLK 675 Query: 683 CGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKI 742 + E + +D + S + + GRFG Y+ N + K + Sbjct: 676 EDIPEKVSLEKALELIAYKEKFDAERIIKTFDDSNIKVLKGRFGPYI--WNGKKKGKGQK 733 Query: 743 LRNGEVAPPKEDPVPLPELPCEK 765 + ++PV L C+K Sbjct: 734 NITIKKVFGNKNPVDLTLKECKK 756 >UniRef50_A8II62 DNA topoisomerase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8II62_CHLRE Length = 772 Score = 543 bits (1400), Expect = e-153, Method: Composition-based stats. Identities = 249/791 (31%), Positives = 363/791 (45%), Gaps = 92/791 (11%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 +V+VESP KAK I +LG Y V +S GH+RDLP +A + + + Sbjct: 1 VVVVESPTKAKKIQGFLGDKYKVLASYGHVRDLPPKAGSAAAAGVAGEEE---------- 50 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +W ++VL ++E+ A A + LATD DREGEAI+WH+ Sbjct: 51 -------------DWYLDWQVLDVARPRMAEIAGAATGAPLLVLATDPDREGEAISWHIS 97 Query: 125 EVIGGDD-----ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 + + R+ F EITK+A+ A +++ V+A +ARR +D +VG+ + Sbjct: 98 QELEKRGVLRKVGGVQRITFTEITKSAVTNALAAGRQVSQPLVDAYRARRALDYLVGFQL 157 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA------ 233 SP+LW+K+ SAGRVQSVA+RLV ERE I+AF P +W + A PS A Sbjct: 158 SPVLWRKLPGARSAGRVQSVALRLVCEREAAIEAFNPLAYWSIAAMLAPPSRGAAAAAAA 217 Query: 234 ---------LALQVTHQNDKPF---RPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 + ++TH + + ++ + + ++ +V + PG Sbjct: 218 AAAGPTAALIRSRLTHADGRRLGGMDIRSQAEAEELARRIQSGPVTVARVVVRQQQRHPG 277 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-------GYITYMRTDSTNLSQDAVNM 334 APF TSTLQQ AS RLGF +TM +AQ+LYE G ITYMRTD ++S +AV Sbjct: 278 APFTTSTLQQEASRRLGFSAARTMRVAQQLYEGAGVCTGEGLITYMRTDGVSISAEAVAE 337 Query: 335 VRGYISDNFGKKYLPESPNQYA-SKENSQEAHEAIRPSDVNVMAES--LKDMEADAQKLY 391 +R + FG+ +P P Y +N+QEAHEAIRP+ + S ++ D LY Sbjct: 338 LRAANAAMFGRGCVPPQPRWYKSRAKNAQEAHEAIRPTRPAAVTPSSLPAALDPDQAALY 397 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRL--KARGRILRFDGWTKVMPALRKGDEDRI 449 LIWR+ VA QMT A YD ++ A RL +A GR+LR G+ + + + Sbjct: 398 DLIWRRAVASQMTSAAYDVVSVEFEADGGRLGLRASGRVLRDPGYLRAYNDDEPAEGEEP 457 Query: 450 LPAV-------------NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPST 496 P + L +L QH T+PP RF+EASLV+ LE+RGIGRPST Sbjct: 458 APEAEAAGGGEDEGAAARENQGLAAQQLLALQHATRPPPRFTEASLVRALEERGIGRPST 517 Query: 497 YASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 YA I++ +QDRGYV E R +G ++T LE F ++YDFT+ ME LD VA+ Sbjct: 518 YAPIMTLLQDRGYVCREGRALLPTSLGRVLTSFLEHYFATWVDYDFTSDMEGRLDDVASG 577 Query: 557 EAEWKAVLDHFFSDFTQQL------DKAEKDPEEGGMRPNQMVLTSIDCPTCG-RKMGIR 609 +A W+ VL F+ F + + G CP CG ++ ++ Sbjct: 578 KAAWRRVLSAFWGPFQAAVGSMAAIRTTQPPGAPGAAAGPAPQRDPRRCPKCGVGRLVLK 637 Query: 610 TASTGVFLGCSGYALPPKERCKTTINLVPENE----------VLNVLEGEDAETNALRAK 659 + G F+GCS +A +C L+P L G +T Sbjct: 638 PSRYGGFIGCSNFADEA-LQCDFARPLLPSEGADGGSCVPFNATERLLGSHPDTGQPVYV 696 Query: 660 RRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMH 719 R P G + + K E + + G + Sbjct: 697 RLGPY-GLYVQAGDAPKKEPKKKKTGF--TIQSVTLEAALALLALPRTLGLHPGDGQPVV 753 Query: 720 LKMGRFGKYMA 730 G FG Y+A Sbjct: 754 ANTGPFGPYVA 764 Score = 48.6 bits (114), Expect = 0.001, Method: Composition-based stats. Identities = 16/84 (19%), Positives = 20/84 (23%), Gaps = 10/84 (11%) Query: 759 PELPCEKSD-AYFVLRDGAAGVFLAANTFPK----SRETRAPLVEELYRFRDRLP--EKL 811 C K VL+ G F+ + F R L E +P Sbjct: 622 DPRRCPKCGVGRLVLKPSRYGGFIGCSNFADEALQCDFARPLLPSEGADGGSCVPFNATE 681 Query: 812 RYLADAPQQDPEGNKTMVRFSRKT 835 R L G VR Sbjct: 682 RLLGS---HPDTGQPVYVRLGPYG 702 Score = 44.7 bits (104), Expect = 0.018, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 31/87 (35%), Gaps = 9/87 (10%) Query: 705 DGPIVECEKCG-SEMHLKMGRFGKYMACTNE-----ECKNTRKILRNGEVAPPKEDPVPL 758 C KCG + LK R+G ++ C+N +C R +L + P Sbjct: 620 QRDPRRCPKCGVGRLVLKPSRYGGFIGCSNFADEALQCDFARPLLPSEGADGGSCVPFNA 679 Query: 759 PE---LPCEKSDAYFVLRDGAAGVFLA 782 E + +R G G+++ Sbjct: 680 TERLLGSHPDTGQPVYVRLGPYGLYVQ 706 >UniRef50_Q4QPE8 DNA topoisomerase n=23 Tax=Proteobacteria RepID=Q4QPE8_HAEI8 Length = 686 Score = 543 bits (1399), Expect = e-152, Method: Composition-based stats. Identities = 147/678 (21%), Positives = 243/678 (35%), Gaps = 84/678 (12%) Query: 4 ALVIVESPAKAKTINKYLG-------------SDYVVKSSVGHIRDLPTSGSAAKKSADS 50 L + E P++ I K LG V +GH+ + Sbjct: 7 KLFLCEKPSQGNDIAKVLGATKRGEGCLSTPDGQLTVTWGIGHLVEQFNPEEYDPAFKKW 66 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLAT 110 P + +K + + +L ++A + +AT Sbjct: 67 A-------------------FETLPIIPGKWGLSPKKETKKQFNVVMKLIKQAKLVVIAT 107 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQQAR 168 D+DREGE IA L ++ G + R+ + + +IR+A E + A AR Sbjct: 108 DIDREGETIARELLDLAGFR-GQIKRLWLSALDDTSIRKALGALKNNEETLPLYYAGLAR 166 Query: 169 RFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 D ++G S L + LS GRVQ+ + LVV R+REIK F+P++ + + Sbjct: 167 SRADWLIGMNFSRLYTLLAQQQGYQGKPLSVGRVQTPTLSLVVNRDREIKNFIPKQHFAL 226 Query: 223 DASTTTPSGEALALQVTHQ--NDKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTSK 279 + + V + D ++ + QAA + + + V E K Sbjct: 227 QVMLSDGNQHFATQYVIPEQYCDPDGLCLSAQVIQAANQQIRQFGQAKVESVETKRERQN 286 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGY 338 F S LQ A+ G G ++ + +AQ LYE TY RTD L + Sbjct: 287 APLCFALSDLQSEANRLYGLGAQRVLDIAQSLYETHKATTYPRTDCGYLPESQFAEAPQI 346 Query: 339 ISDNFGKK--------YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKL 390 I L + + AH I P+ + + M + KL Sbjct: 347 IQCLLQSDNRLHPLAGMLNLNQKSRVWNDKKITAHHGIIPTMI---KADISKMSDEELKL 403 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED--R 448 Y LI R+++A + ++ D T + + G L ARG +L GW + D+D + Sbjct: 404 YDLIRRRYLAQFLPVSETDKTQIILKCGQHILSARGNVLIAPGWKILFGKSLDEDDDAPQ 463 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGI 491 LP + +G + + T PP F+E +L+ + E G+ Sbjct: 464 ALPTLKQGQICQISDSEIKTLQTSPPNHFTEGTLLTAMKNAARFVTDERLKQRLRETEGL 523 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G +T A I + D+G+++ + + A + D L + L + TA E +L+ Sbjct: 524 GTEATRAGTIQGLIDKGFLKKKGKSLLATDEAMTLIDNLPQM---LKDPGLTALWEQALN 580 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 Q+A + + + K G + CP CG M R Sbjct: 581 QIAERTLSLEVFMQKQEVFVRHLMADCLKKGMSLGN------IEIRKCPKCGAPMIKRNG 634 Query: 612 STGVFLGCSGYALPPKER 629 G F GCS Y Sbjct: 635 KNGAFFGCSAYPNCQHIE 652 Score = 57.0 bits (136), Expect = 3e-06, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 15/39 (38%) Query: 762 PCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 C K A + R+G G F + +P + ++ Sbjct: 621 KCPKCGAPMIKRNGKNGAFFGCSAYPNCQHIENIDSKKN 659 Score = 42.4 bits (98), Expect = 0.070, Method: Composition-based stats. Identities = 11/60 (18%), Positives = 23/60 (38%), Gaps = 1/60 (1%) Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEV 748 + + + + I +C KCG+ M + G+ G + C+ C++ I Sbjct: 601 RHLMADCLKKGMSLGNIEIRKCPKCGAPMIKRNGKNGAFFGCSAYPNCQHIENIDSKKNT 660 >UniRef50_Q3M6J7 DNA topoisomerase n=12 Tax=Cyanobacteria RepID=Q3M6J7_ANAVT Length = 728 Score = 542 bits (1396), Expect = e-152, Method: Composition-based stats. Identities = 225/726 (30%), Positives = 356/726 (49%), Gaps = 72/726 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L++VESP K K +++ LGS+++V++S GHIR+L G A + + Sbjct: 1 MPKRLLVVESPGKVKKLSQILGSEWIVRASCGHIRELSDEGEDALGFSMDGGSVQCHYVP 60 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +D+R ++ + +LK A++ + LATD DREGE IA Sbjct: 61 RDQR------------------------SKETIQQLKSAAKQVSEVVLATDPDREGETIA 96 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+EV+G + RVV+ EIT +A++ A P +L+++ V A R +D++VGY S Sbjct: 97 WHLKEVLGLREP--KRVVYTEITASAVQSAIAHPRKLDLNLVGAGLCRDCLDKLVGYKGS 154 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 PL+W S GRVQS + L+ +REREI++FVP+++W V V Sbjct: 155 PLVWALNNGAKSVGRVQSSTLHLICQREREIQSFVPQDYWSVWVDYVEGFRAFYKGAVNT 214 Query: 241 QNDKPF--------------------RPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 ++D P R + + + V + + +++ E K +P Sbjct: 215 RSDSPETEVEIHDDAAGNSTTAPESTRVLAEAEANRLVEEARRHPHQIVQYEGKIANRQP 274 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS 340 PFITSTLQQAA ++L F +KTM +AQ+LYEAG ITYMRTDS LS + R ++ Sbjct: 275 PPPFITSTLQQAAGSKLKFAPEKTMQLAQKLYEAGLITYMRTDSVMLSPEFCESARQWLE 334 Query: 341 DNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLK-DMEADAQKLYQLIWRQFV 399 N + +P+ ++ S + +Q+ HEAIRP+DV + L+ ++ D LY +IW++ + Sbjct: 335 QNDPQN-VPKQVARHRSSKTAQQGHEAIRPTDVFRPSAQLRIELSTDEFNLYVMIWKRAI 393 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 A Q PA+ T + +G +ARG+++ F G+T+ P L K D +LP + +G + Sbjct: 394 ASQCRPAQLRKTVVITQSGQILWQARGQVVEFLGYTRYWPNLSK---DTLLPTLQQGQMV 450 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 TL + T+PP R+SE LV+ +E++GIGRPSTY+ I+T++ RGYV + + Sbjct: 451 TLENAGHEKKQTQPPPRYSEPKLVQLMERKGIGRPSTYSPTIATLKKRGYVELTKDNLHP 510 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF-FSDFTQQLDKA 578 +G V L++ +L+ +FTA+MEN+LD +A + W+ L + + F L KA Sbjct: 511 TNLGLEVDTFLQKALPDLLEAEFTAKMENALDAIAEGKQPWQIYLTTWNQNYFAPALAKA 570 Query: 579 EKDPEEGG-----MRPNQMVLTSIDCPTCGRKMGIRTA---STGVFL----GCSGYALPP 626 + + G P Q + CP C + + FL GC L Sbjct: 571 KTIAVDSGNPTKTFPPRQYDTSRTRCPDCNNFLSKIPSSKLKKKYFLKCTSGCENTVLFW 630 Query: 627 KERCKT-----TINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSY---LIDPKR 678 E KT T + + CP C ++ Y K+ Sbjct: 631 SEFSKTWQAPRTKDDKMAENGQKNHLSPATKLPTQLTAYPCPVCKRPLEEYTYTKDGQKK 690 Query: 679 KLHVCG 684 + C Sbjct: 691 TMLRCS 696 >UniRef50_B5TTQ4 TraB n=3 Tax=environmental samples RepID=B5TTQ4_9BACT Length = 750 Score = 541 bits (1393), Expect = e-152, Method: Composition-based stats. Identities = 237/824 (28%), Positives = 383/824 (46%), Gaps = 97/824 (11%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 LVIVESP K I +LGSD+ V +SVGH+RDLP G Sbjct: 2 NLVIVESPNKCSKIGSFLGSDFKVVASVGHVRDLPRKG---------------------- 39 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKE----------KVVSELKQLAEKADHIYLATDLD 113 +G+D +++ Y +P + K + ++K KAD IYLATD D Sbjct: 40 -------LGIDIANDFAMEYSFIPDAKVNDRTFDGGEKRIEKIKAFLNKADKIYLATDPD 92 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 REGEAI+WHL+E +G +D ++ R+ FNEI++ AI++A N L+ V AQ+ARR +DR Sbjct: 93 REGEAISWHLKECLGLEDGQFERIEFNEISEKAIKEAINNGRGLDYQLVYAQEARRALDR 152 Query: 174 VVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA 233 +VGY+VSP+ + + SAGRVQS AV +VV RE EI+ F + V+ S + Sbjct: 153 LVGYLVSPMASNLMGQPSSAGRVQSPAVLIVVLREIEIQKFKVTNHFGVNLSFDKEPKKW 212 Query: 234 LALQVTHQN--DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 ++ VT + + +++ + + + VL +K S +PF T+ L Q Sbjct: 213 ISQWVTTEFVTEDQPYVLDRSLAEEVA---KTKKVKVLNCTEKTEYSNAPSPFSTALLLQ 269 Query: 292 AASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES 351 AAS LGF ++T AQ L+E G ITY+RTD N++ ++V + Y +++ + LPE Sbjct: 270 AASVALGFSPQQTTKAAQALFEQGAITYIRTDGLNIADESVEEIFAYANEH--QFSLPEK 327 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 PN++ K+ +Q AHEAIRP + + L + + LYQLIW + ++ Q+ A+Y + Sbjct: 328 PNKFKEKDGAQNAHEAIRPVHI--TDKDLGK-SPEQKALYQLIWERTISSQLAKAEYKAV 384 Query: 412 TLTV--GAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI---LPAVNKGDALTLVELTP 466 TL + G ++ A+ R L GW DE+ +P + G + + Sbjct: 385 TLELLSEDGKYKFHAKSRELIKKGWMVFGKDCLNEDENEPSGVVPVLEVGSVVDVESGEV 444 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 TKPP R++EASL+K+LE GIGRPSTY+SI++ I ++G++ VE + K+G + Sbjct: 445 IAKQTKPPKRYTEASLIKKLESCGIGRPSTYSSIMANILNKGFLEVEKKVLKPTKLGNDL 504 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG 586 L + ++ ++ +ME LD++A+ E + +V+ ++ Q+L A K Sbjct: 505 IGSLLKAKFSFLDLHYSKEMELQLDKIASGETSYNSVVSALYTQLAQELSTASK------ 558 Query: 587 MRPNQMVLTSIDCPTCGRKMG--IRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 + +I CP C ++ T + F CS E CK ++N Sbjct: 559 ----LTAINAIPCPKCKSQLKKFKNTKTNQFFWICSN------EDCKHSMN--------- 599 Query: 645 VLEGEDAETNALRAKRRCPKCGTA-MDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKG 703 +D + CPKC T ++ + ++ N+ C ++ ++ Sbjct: 600 ----DDKGKPVEKVIHSCPKCKTGRLNKFQNSQTKEFFWICNDQECKHSMDDKKGQPVEK 655 Query: 704 YDGPIVECEKCGSEMHL-KMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELP 762 P C KC + + K C N E + + L Sbjct: 656 IKYP---CPKCSTPLFRSKKEGKDPIWFCPNRETDCKVFLPEVNKK-------PLLEVYS 705 Query: 763 CEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDR 806 C + + +GA G F + P + +F + Sbjct: 706 CPQCASDLRRINGANGYFWGCTNYKNGCSATYPDQKGKPKFEVK 749 >UniRef50_B5JHP8 DNA topoisomerase n=2 Tax=Bacteria RepID=B5JHP8_9BACT Length = 781 Score = 541 bits (1393), Expect = e-152, Method: Composition-based stats. Identities = 167/834 (20%), Positives = 289/834 (34%), Gaps = 124/834 (14%) Query: 4 ALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 +V+ E P+ A+ I K+L G+ + V + GH+ +L + Sbjct: 2 KVVLAEKPSVARDIAKHLKAGQRHDGYLEGNGWAVTWAFGHLVELKEPEEYRPEWKSWKV 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P +E G +K + +K+L +A+ I ATD Sbjct: 62 SLLPIVP-----------------DQFELRARGDDGAKKQLETVKKLFGEAEEIICATDA 104 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 REGE I ++ E G + R+ + +T AI + F K E A + R Sbjct: 105 GREGELIFRYILEWSGCEAKPVKRLWISSLTGAAISKGFAKLREGKDFDTLHYAARCRSE 164 Query: 171 MDRVVGYMVSPLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D +VG + + + LS GRVQ+ + ++V R+ EI+ F E+FWE+ Sbjct: 165 ADWIVGMNATRYFTVEYGKRNLLLSLGRVQTPILAMIVGRDMEIENFKSEDFWELHTECR 224 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 T + +E+ +A ++ V + + K + P F + Sbjct: 225 D----------TKFRHTGGKIQKEEEAKALFEKVDGQPLVVSDVQQKNENTNPPLLFDLT 274 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD-------AVNMVRGYIS 340 LQ+ + R GF +T+ +AQ LYE ITY RTDS LS D + ++ Sbjct: 275 ELQREMNRRYGFTADQTLRIAQNLYEQKRITYPRTDSRYLSTDLQPTIGPLLERLKAIKE 334 Query: 341 DNFGKKYLPE-SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFV 399 L + S + ++ H AI P+D + +++ AD +++Y I + + Sbjct: 335 KEIAPLELDKLSFGKRIVDDSKVSDHHAIIPTD-----DLPRNLNADEERVYDAILVRLI 389 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP------------ALRKGDED 447 A TT+ A + +ARG +L GW + P + E Sbjct: 390 AVFYPACVKAVTTVEAKASEETFRARGTVLLEAGWQALYPQLFAIASKKKGAKGKAAPEP 449 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGI 491 +P G++ + + T PP RF+EA+L+ +E +G+ Sbjct: 450 AAMPHFQVGES-NPHRPSIEKFKTNPPKRFTEATLLSLMETAGKIVEDEELKEALKDKGV 508 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G P+T ASII + R YV + + + G + +++ L + + T E L Sbjct: 509 GTPATRASIIEVLIQRKYVERKKKNLISTYSGRHLISLIQD--ERLKSPELTGDWEFRLK 566 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 +V E + KA + + L + CP C + Sbjct: 567 KVERGEQDPKAFMSDVVEYTKEILAN--------DAEKTVDLKNLGPCPKCSAPVM---- 614 Query: 612 STGVFLGCSGYALPPKERCK---TTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 GC+ + K K I P + G E + K G Sbjct: 615 RGNTGYGCTRWREGCKFVVKDGVFGITFQPPLMRELLFNGRSLEPQPISDK------GKK 668 Query: 669 MDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKY 728 + +++ K+ + +C C S + G G Sbjct: 669 LLGFVVLGKQGALK----------YELVESSQETHGQAKFGDCPLCKSAIVE--GEKG-- 714 Query: 729 MACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLA 782 C N + I + P E+ E + AG + Sbjct: 715 YGCCNWKNGCKFIIWKQVAQRPISEEEARFLLEKGET--SQLEGFKSKAGKEFS 766 >UniRef50_C9KMQ0 DNA topoisomerase n=5 Tax=Bacteria RepID=C9KMQ0_9FIRM Length = 821 Score = 540 bits (1392), Expect = e-152, Method: Composition-based stats. Identities = 175/857 (20%), Positives = 293/857 (34%), Gaps = 118/857 (13%) Query: 5 LVIVESPAKAKTINKYL------GSDY------VVKSSVGHIRDLPTSGSAAKKSADSTS 52 L I E P+ + + K L Y VV GHI K + Sbjct: 3 LYIAEKPSVGRELAKCLTGPVTRRDGYLVTKDGVVTWLFGHILRQAEPEEYDPKYKRWRA 62 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 P+ V EK + +K L EKAD I D Sbjct: 63 DDLPIIPEH-------------------WKLFVDKDCEKQFAIVKSLIEKADEIVHGGDP 103 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQARRF 170 DREG+ + + + +G + R++ N + + +I++A + + + AR Sbjct: 104 DREGQLLVDEVLDYLG-NKKPVRRILLNALDEKSIKKANASLRDNRDFFNLKQSALARAR 162 Query: 171 MDRVVGYMVSPLLWKKIAR------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 D ++G +S R L GRV++ + LVV REREI+ F P ++ + Sbjct: 163 ADWLIGMNLSRAYTLAARRAGHERLVLPIGRVKTPTLSLVVRREREIEHFKPVTYYLIRG 222 Query: 225 STTTPSGEALALQVTHQN----DKPFRPVNKEQTQAAVSLLEKARY-SVLEREDKPTTSK 279 + +G A D R ++K+ ++ E+ + +V+ K + Sbjct: 223 TFQHENGSFEAQWKPKDTMAGLDSENRLIDKKIADEKLAFFEELPHDAVISAYQKAKKQE 282 Query: 280 P-GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY 338 P PF STLQ A R G+ + + AQ+LYE TY R+D L + + Sbjct: 283 PQPLPFSLSTLQVLAGKRFGYAPQLVLDTAQKLYEKKLTTYPRSDCEYLPTNQLGEAATI 342 Query: 339 ISDN---------FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQK 389 +S K A + AH AI P+ V + M + + Sbjct: 343 LSHLAKAGDAQVAAWVKAANPKQKSRAWNDKKISAHHAIIPTTVQ---ADVTKMTQEERN 399 Query: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED-- 447 LY LI R ++A YD T + V D A GR R GW + + +K E Sbjct: 400 LYHLIARAYLAQFYPVHTYDQTKVEVQYKDETFTASGRTERDLGWKVMYQSQKKKQESDE 459 Query: 448 -----------RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK-------- 488 + LPA+ K DA+ + TKPP RF+ ++L+ +++ Sbjct: 460 EDDKEDKEESAKTLPAMKKKDAVAWQRGRMLEKMTKPPTRFTASTLLAGMKEIHKYVKNP 519 Query: 489 ---------RGIGRPSTYASIISTIQDRGYV--RVENRRFYAEKMGEIVTDRLEENFREL 537 GIG +T A+II + R ++ + + ++ D L + EL Sbjct: 520 EAKKQLKDVYGIGTEATRATIIDDLIRRKFMKAEGKKKYLVPTPAAYLLVDALPD---EL 576 Query: 538 MNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSI 597 D TA E+ L ++ E L + + KA + V Sbjct: 577 TYPDSTAIWEDKLHSMSEGEGSLADFLQGQIAFTRKLCAKATDV--------HMEVKGEN 628 Query: 598 DCPTCGRK-MGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNAL 656 CP C + + R GVF GCS Y +C+ T N + + LE A Sbjct: 629 VCPRCHQGVLTKRKGKNGVFWGCSNYP-----KCRMTCN---DKDGKPDLEDAKARLARR 680 Query: 657 RAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGS 716 + ++ P G + + + + E Sbjct: 681 PCAAAPAAVSASALAWQAHPSSA-QAAGGYSSAESADDIAALNALFSPADYAARMEADAK 739 Query: 717 EMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKS-DAYFVLRDG 775 + + ++ K + + + V + C + + + G Sbjct: 740 SYAAQQKKASSSWQSWADKPKYSASPMEHM------AKDVASSDYLCPRCREGHLRSIYG 793 Query: 776 AAGVFLAANTFPKSRET 792 GVF + +P+ T Sbjct: 794 RNGVFWGCSNYPRCTAT 810 >UniRef50_B7J7I8 DNA topoisomerase I, putative n=1 Tax=Acidithiobacillus ferrooxidans ATCC 23270 RepID=B7J7I8_ACIF2 Length = 705 Score = 538 bits (1387), Expect = e-151, Method: Composition-based stats. Identities = 218/737 (29%), Positives = 324/737 (43%), Gaps = 68/737 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 L+IVESP KA I LGS + VK++VGHIRDLP G AA Sbjct: 2 TKLLIVESPTKAHHIQAMLGSGWSVKATVGHIRDLPIKGDAAYVRPP------------- 48 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 +++ +YE+ K V L+ A A+ +Y+ATD DREGEAIAWH Sbjct: 49 ---------------DFKLNYEITERASKTVPALRAAARDAESVYIATDPDREGEAIAWH 93 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 + +V+G RV + E+T+ AIR+A P +N+ V AQ+ARR +DR+VG+ VS Sbjct: 94 VCQVLGIKPGAAKRVTYQEVTEPAIRKAIAAPRTVNMPLVAAQEARRALDRIVGWEVSGP 153 Query: 183 LWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT-TPSGEALALQVTHQ 241 L I SAGRVQ+ A+ LVV RE+ I+ F P +++V A + Sbjct: 154 LSNAIGSRASAGRVQTPALSLVVAREQAIRQFKPTPWFQVLAHVAGKDAAPDWRAVWVDG 213 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + +K +A L V + E KP P PF TS++Q + L V Sbjct: 214 TQEGEYFQDKAHAKALADALPSMALKVTKAETKPVRKPPAPPFTTSSMQMDGARALKAPV 273 Query: 302 KKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENS 361 M AQ L+E G+ITY RTDS NLS++ ++R + L E+P ++ SK + Sbjct: 274 DAIMKAAQSLFEHGHITYHRTDSPNLSEEGEGLLRAALKKE--NLPLVETPRRWRSKGGA 331 Query: 362 QEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFR 421 QEAHEAIRP+ V D+ Q LY LI ++ +A QM A Y T+ T+ G F+ Sbjct: 332 QEAHEAIRPTRPMVRQAGENDL---EQALYDLIRKRALASQMPDAVYQQTSCTLDGGMFQ 388 Query: 422 -----LKARGRILRFDGWTKVMPALRKGDED------RILPAVNKGDALTLVELTPAQHF 470 +A G +L+ GW + + +E +P + GDA+ Sbjct: 389 GRPAVFRAVGSVLKDPGWMALYRETAEDEEGTENPAANPVPRLAVGDAVRAARGECLSKT 448 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR--FYAEKMGEIVTD 528 TK P R++E++L+K LE G+GRPSTYASI+ + R Y+R + + YA ++GE + + Sbjct: 449 TKAPPRYTESTLIKALEDHGVGRPSTYASILKNLFAREYIRRKGKSPALYATELGEKIVE 508 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 L + N D+T ++E LD++ + + +L F+D + LD G Sbjct: 509 ALS--VFDFSNVDYTREVEADLDRITEGQMRPRDLLAKSFADIQRILDAMPTQARAQGRP 566 Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 R++ + F CS P + P E + +G Sbjct: 567 CPIEGCDGTV-----RRLESKRKPGVFFWMCSNRDAHPLLQDNDGEPGAPFAERVEAGDG 621 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 CP+CG A CG G ++ K ++ Sbjct: 622 P-----------ACPECGAATSRQETGKGYGYFRCGKG---HGSWWDDKGSLGKKWEDRA 667 Query: 709 VECEKCGSEMHLKMGRF 725 G Sbjct: 668 PAQGAASGPARKNTGSK 684 >UniRef50_A3EW25 DNA topoisomerase n=3 Tax=Leptospirillum RepID=A3EW25_9BACT Length = 684 Score = 538 bits (1387), Expect = e-151, Method: Composition-based stats. Identities = 144/677 (21%), Positives = 254/677 (37%), Gaps = 83/677 (12%) Query: 5 LVIVESPAKAKTINKYL------GSDY------VVKSSVGHIRDLPTSGSAAKKSADSTS 52 L I E P+ + I + L G+ + +V GHI + +K A Sbjct: 3 LFIAEKPSLGRAIAEVLPGPHKKGAGFLETGGGIVTWCFGHILEAAPPEEYDRKWAAW-- 60 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 G P +P + ++ +++L +A I A D Sbjct: 61 ---------------PGSSGDLPIVPKTWKLSPVPSAKAQLAVIRKLLGEASEIVHAGDP 105 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQQARRF 170 DREG+ + + E +G R+ + + + A+RQA + A Q R Sbjct: 106 DREGQLLVDEVLEYLGNR-KPVLRIWLSSLDEKAVRQALSGLRSNREFAAMKEAAQVRSR 164 Query: 171 MDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 D +VG +S + LS GRVQ+ ++LVV+R+REI++FV ++F+ V+A Sbjct: 165 ADWLVGMNLSRAYSIAARKNGNPVAVLSIGRVQTPTLKLVVDRDREIESFVSKDFFTVEA 224 Query: 225 STTTPSGEALALQVTHQN----DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 + P G + + +N D R +++ + + + +L+ + P Sbjct: 225 TLEAPGGAFKTVWMPAENHPALDAAGRCIDRTVALGVANGTKAQKG-ILDIGKTEKSEPP 283 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS 340 + STL AS + K+ + AQ LYE TY RTD L Q R +S Sbjct: 284 PLVYALSTLTMDASKKYAMSAKEVLDTAQSLYEKKLTTYPRTDCEYLPQTQWGEAREILS 343 Query: 341 DN-------FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 + A AH I P+ A + +++ L Sbjct: 344 ALGRLPGLSSAASQADSARRSRAWNTEKVTAHHGIIPTR---EAGRAGGLSEKEVRIFDL 400 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE----DRI 449 + R+++A P +Y T + G +A+G GW V ++ + Sbjct: 401 VCRRYLAQFYPPFRYTETIVRTRLGGEPFQAKGTTPLDTGWKSVYGPEPDREDRKEPEPP 460 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR-----------------GIG 492 LPA++ GD + + + T PP+ +++ +LV ++ G+G Sbjct: 461 LPALSSGDPVVARDCSVVARKTTPPSPYTDGTLVAAMKNVHRAMSNPEDKKILNETDGLG 520 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 +T ASI+ T+ RGY+ R + G + D +E + + TA E SL+ Sbjct: 521 TEATRASILETLFSRGYLEKSKRAIRSTPRGRALIDAVE---PIVASPVTTAVWERSLES 577 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAS 612 +A + ++ ++ +D + + + + C CG + Sbjct: 578 IATGQG------ENSGEFLSKIVDTVSRLTKTALALRVVIPVEGKICSECGGVLRRLEGK 631 Query: 613 TGVFLGCSGYALPPKER 629 G FLGCSGY Sbjct: 632 FGPFLGCSGYPACRHLE 648 Score = 49.7 bits (117), Expect = 6e-04, Method: Composition-based stats. Identities = 8/35 (22%), Positives = 13/35 (37%) Query: 757 PLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRE 791 P+ C + +G G FL + +P R Sbjct: 612 PVEGKICSECGGVLRRLEGKFGPFLGCSGYPACRH 646 >UniRef50_O34204 DNA topoisomerase 1 n=8 Tax=Thermotogaceae RepID=TOP1_FERIS Length = 699 Score = 538 bits (1386), Expect = e-151, Method: Composition-based stats. Identities = 245/692 (35%), Positives = 362/692 (52%), Gaps = 62/692 (8%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K ++IVESPAKAKTI + LG+DY V SS GHIRDLP Sbjct: 37 KKKVIIVESPAKAKTIERILGNDYQVISSKGHIRDLPQKQFGVD---------------- 80 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 ++ + +E++PGKE VV ++K+ + L +D DREGEAIAW Sbjct: 81 --------------LNSLKLDFEIIPGKESVVEQIKK-MTSGKEVLLPSDQDREGEAIAW 125 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSP 181 HL ++G + F EIT+ AI++A P E+++++VNAQ ARR +DR+VGYM+SP Sbjct: 126 HLSTILGVKGKNI--ITFTEITERAIKEAVKNPREIDMNKVNAQLARRVLDRIVGYMISP 183 Query: 182 LLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 LLW+ I SAGRVQS A++++ ERERE FVP+++++V L +T Sbjct: 184 LLWRIIKDARSAGRVQSAALKIICERERERYRFVPQKYFKVWIDIAG-----LKAYLTKV 238 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 + K +P + + + L + +++ + K P APFITSTLQQ A+++LGF V Sbjct: 239 DGKKIKPTDITEEISKDVLQKVKSVRLVDIDVKEVRKNPPAPFITSTLQQDAASKLGFPV 298 Query: 302 KKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPES-- 351 KTM +AQ LYE +ITYMRTDST +S A +I NFG++YL ES Sbjct: 299 SKTMKIAQELYEGVDTKEGHTAFITYMRTDSTRVSDVAKEAAEKFILKNFGREYLNESSE 358 Query: 352 ---PNQYASKENSQEAHEAIRPSDVNVMAESLKDM-EADAQKLYQLIWRQFVACQMTPAK 407 +K Q+AHE IRP DVN+ E K++ + D KLY+LIW++F+A QM+ A Sbjct: 359 VASKKGSKTKGKVQDAHECIRPVDVNITPEKAKELLDKDHHKLYELIWKRFIASQMSSAI 418 Query: 408 YDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPA 467 Y + +G + +A R FDG+ KV + E + LVE A Sbjct: 419 YKQYSYDFESGKYVFEASIRERIFDGFEKVYTIDNEPSEKHK--ELKVDQEY-LVEPKSA 475 Query: 468 QHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVT 527 + T PP R++EASLVK LE GIGRPSTYA+II T+ DRGYV + + +G +V Sbjct: 476 EAQTTPPDRYTEASLVKTLEMEGIGRPSTYATIIQTLLDRGYVVKKRKTLIPTILGFVVN 535 Query: 528 DRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGM 587 LE+ F ++++ FTA+ME LD+V N + +WK V+ F +F + L++A+ + Sbjct: 536 HYLEQRFPDIVDKGFTAEMEKELDEVENGKKDWKEVVKSFLKEFNKDLERAKNEF----- 590 Query: 588 RPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 T I C C ++ G++L C + ++ N++ + E Sbjct: 591 -FAIDFDTDITCEDCSGNYKLKVGKYGLYLHCPNCKTNKALKSD-VFGVIDGNKLYVLEE 648 Query: 648 GEDAETNALRAKRRCPKCGTAMDSYLIDPKRK 679 E E N + + + + KR+ Sbjct: 649 QESQEENGEKNSVQSEESSANSGNRKFYRKRR 680 >UniRef50_B8DNH0 DNA topoisomerase n=2 Tax=Desulfovibrio vulgaris RepID=B8DNH0_DESVM Length = 873 Score = 538 bits (1385), Expect = e-151, Method: Composition-based stats. Identities = 162/766 (21%), Positives = 273/766 (35%), Gaps = 131/766 (17%) Query: 1 MGKALVIVESPAKAKTIN----------KYL-GSDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M K L+I E P+ A+ + +L G D++V +VGH+ + A Sbjct: 1 MSKTLIIAEKPSVARELAPLVGATQRRAGFLEGPDHLVSWAVGHLVGIAEPEEQDPAWA- 59 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIY 107 + P VLP + L++L E+ + Sbjct: 60 -----------------GRWTLDQLPMLPPRFRLRVLPETADQFAVLRRLLTDERVTGVI 102 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQ 165 ATD REGE I + + R+ +++T+ +R++ + P + A Sbjct: 103 NATDAGREGELIFRRIYLMAECA-KPVRRLWASDMTEEGLRKSLARLLPDAEKRNLGLAS 161 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D +VG S L + +S GRVQ+ + L+ R REI+ FVP++FW V+ Sbjct: 162 FARAEADWLVGMNYSRLFTVRTGGLVSVGRVQTPVLCLLTARRREIEQFVPQDFWTVEGV 221 Query: 226 TTTPSG--------------------------------------EALALQVTHQNDKPFR 247 T A+ + R Sbjct: 222 FTPGGKGRAAQGGVAAPDASPDATADASPAGTQDTPAPASDAPDSFPAVWHRPPELRETR 281 Query: 248 PVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMM 307 ++++ A + V K + +P PF +TLQ+ A+TR G K T+ Sbjct: 282 VDSEDEASAIANACTGREGVVESVASKAGSQQPPLPFDLTTLQREANTRFGLSAKDTLAH 341 Query: 308 AQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGY---ISDNFGKK-------YLPESPNQYA 356 AQ LYE ITY RTDS +L+++ + + I + + Sbjct: 342 AQALYETHKLITYPRTDSRHLTKELFAEILNHFRAIHHLYPDETMLAVARIKSGKVKFPC 401 Query: 357 SKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVG 416 + H AI P+ + +++Y++I R+F+A A++ ++T+TV Sbjct: 402 VDDRKVTDHHAIIPT---ARKGDPARLSQPERQIYEMICRRFIAAFCAEARFATSTVTVK 458 Query: 417 AGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPAR 476 G+ ARG++ + GW V P + ED LP + KG L ++ TK PA Sbjct: 459 VGEHAFIARGKVFKEKGWLAVEPW--RAAEDTPLPPLRKGARLHTDDIRRVTRQTKAPAH 516 Query: 477 FSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 +++ASL+ +E +RG+G P+T A +I T+ RGYV +R A Sbjct: 517 YTDASLLAAMETAGKLVEDEELRQAMKERGLGTPATRAQVIETLLQRGYVGRHGKRLIAS 576 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK 580 G V + +E ++ + + T E +L + A + + + + ++ Sbjct: 577 DRGMQVAEVIEALLPDVASPELTGTWEKALKDMEAGTATYPQFMHGIRESVWNGVHRIKR 636 Query: 581 DPEEGGMR------PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKE------ 628 R CP CG ++ R G C+G K Sbjct: 637 VGGRNLDRLLDTASERYARTPDGLCPLCGGEV--RETPRG--WACTGQPPAKKRGKAANG 692 Query: 629 -----------RCKTTINLVPENEVLNVLEGEDAETNALRAKRRCP 663 + P E RCP Sbjct: 693 DDSAGQDAARAKRGAKKTGAPNGGPDAAPNSEADGGTPPANGGRCP 738 >UniRef50_C8WG68 DNA topoisomerase type IA central domain protein n=9 Tax=Coriobacteriaceae RepID=C8WG68_EGGLE Length = 849 Score = 537 bits (1383), Expect = e-151, Method: Composition-based stats. Identities = 197/848 (23%), Positives = 325/848 (38%), Gaps = 110/848 (12%) Query: 4 ALVIVESPAKAKTINKYLG---------------------SDYVVKSSVGHIRD------ 36 LV+ E A+ I LG ++V GHI + Sbjct: 2 KLVVTEKNDAAQKIADLLGVKKPKADKVYSTPVYRFDVDGEEWVTIGLRGHILEPDFAPT 61 Query: 37 LPTSGSAAKKSADSTSTKTA---------------KKPKKDERGALVNRMGVDPWHNWEA 81 + + K +D +M P+ + Sbjct: 62 MVYKKRGGWQGVTEEGETLPAELPASLPKPPFKKKKPFTEDGVELKSWKMDALPYLVYAP 121 Query: 82 HYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDDA--RYSRVVF 139 LP +++++ LK LA+KAD + +ATD DREGE I I + SR + Sbjct: 122 -INKLPKEKEIIRSLKNLAKKADSVIIATDFDREGELIGSDALSCIQEVNPTAPVSRARY 180 Query: 140 NEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWK----KIARGLSAGR 195 + TK I AF+ EL+++ +A +R+ +D + G +++ L S+GR Sbjct: 181 SAFTKEEITHAFDNLVELDVNLASAGASRQDIDLIWGAVLTRYLTLVKFAGYGNVRSSGR 240 Query: 196 VQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQ 255 VQ+ + LVV RERE AFVPE++W + + A T R + + Q Sbjct: 241 VQTPTLALVVARERERLAFVPEDYWVIRGAFGADPDSFEAPHAT------ARFKAEAEAQ 294 Query: 256 AAVSLLEKAR-YSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA 314 A ++ +E A +V E K T +P APF T++L AAS G +TM +A+ LY Sbjct: 295 AVMAHVEGATRATVASVEKKKRTVQPPAPFNTTSLMAAASAE-GLSPARTMRIAESLYMD 353 Query: 315 GYITYMRTDSTNLSQ--DAVNMVRGY----ISDNFGKKYLPESPNQYASKENSQEAHEAI 368 GYI+Y R D+T D + V+ + K+ L + + H I Sbjct: 354 GYISYPRVDNTVYPSSLDLADTVKAISGNPAYAPYCKELLAKGKLTATRGKKETTDHPPI 413 Query: 369 RPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRI 428 P+ + D+ KLY LI R+F+A A + T +T+ A+G + Sbjct: 414 YPT----AKATPDDLAPADYKLYNLIARRFLATLSEAAVIEGTKVTLDVNAEPFVAKGDV 469 Query: 429 LRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK 488 L G+ + P K DE LPA+++G+ + + T+PPAR+S+ L++E+EK Sbjct: 470 LVKPGYRAIYPYGLKKDE--QLPALSEGETVAFNGAVCTKKQTEPPARYSQGKLIQEMEK 527 Query: 489 RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN 548 G+G ST +II + Y + ++G V D L++ + + + TA++E Sbjct: 528 LGLGTKSTRHAIIERLYAVKYCMND--PIEPSQLGMAVCDALDKFAPHITHPEMTAELEE 585 Query: 549 SLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTS---IDCPTCGRK 605 +D +A V+D + ++QL EE V CP CG+ Sbjct: 586 EMDNIAEGRTTKAQVVDTSRNLLSEQLASLLPHSEEVKEALADAVAADAYVGPCPKCGKD 645 Query: 606 MGIRTASTGV--FLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCP 663 + +R + F+GC+G+ C T L + CP Sbjct: 646 LQLRASQKTRSMFIGCAGWP-----DCDVTYPL--------------PKGKVEAVPEPCP 686 Query: 664 KCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMG 723 CG + +C + P C + + K + K Sbjct: 687 TCGMPQVKVTAFRSKPRTICID-PHCSTNQEPDVVVGECPACKEKGIQAK---LIAQKNP 742 Query: 724 RF-GKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFL 781 R +++ C N ++C + + G + E CE A V+ A G + Sbjct: 743 RTLKRFIRCENYDDCGTGYPLPQYGALTAT--------EEVCEHCGAPMVIVTTARGPWK 794 Query: 782 AANTFPKS 789 F Sbjct: 795 LCPNF-DC 801 >UniRef50_Q18KP8 DNA topoisomerase n=6 Tax=Halobacteriaceae RepID=Q18KP8_HALWD Length = 857 Score = 537 bits (1383), Expect = e-151, Method: Composition-based stats. Identities = 197/854 (23%), Positives = 347/854 (40%), Gaps = 87/854 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+I E A+ I L D D + K + D Sbjct: 7 LIITEKDNAARRIADILSGDSATA-------DREQGVNVYKWGGKRCIGLSGHVVAVDFP 59 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 + V+P +A E P K+ +V+ LK+LA +A + +ATD DREGE I Sbjct: 60 QEYSDWRDVEPVELIDAPIEKNPTKQNIVTTLKKLARRARRVIIATDYDREGELIGKEAY 119 Query: 125 EVIGGDDA--RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 E++ + RV F+ IT+ ++ AF P +L+ + A +AR+ +D V G ++ Sbjct: 120 ELVRRVNESTPIDRVRFSSITEESVTTAFENPDDLDFNLAAAGEARQVIDLVWGAALTRY 179 Query: 183 LWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWE-----------VDASTT 227 L + +S GRVQ ++L+V+REREI+AF PE++WE ++ ST Sbjct: 180 LSLSAGQLGSDFISVGRVQGPTLKLIVDREREIEAFDPEDYWELFVDLTQADKPIEVSTD 239 Query: 228 TPSGEALALQVTHQND--KPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPF 284 + E A H +D + R + + LE A V + + T +P APF Sbjct: 240 DTAAEFEAQYFYHADDGTEAERITEESTAKTVFETLESASIAHVDSVKRRTRTDEPPAPF 299 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGYISD- 341 T+ AA + +G+ ++ M +A+ LY AGYITY RTD+T + ++ + Sbjct: 300 NTTQFISAAGS-IGYAAQRAMDIAEDLYTAGYITYPRTDNTVYPDELDPRELIEALTNGS 358 Query: 342 NFG---KKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 FG + L + + + H I P+D +++ D ++Y+LI R F Sbjct: 359 RFGSDARDVLDQETLSPTTGDEETTDHPPIHPTDELPKP---SELDDDKWEVYELIVRHF 415 Query: 399 VACQMTPAKYDSTTLTVGAGD-FRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 +A PA ++ + D + +K+ GR L G+ V P + ++P + G+ Sbjct: 416 LATVSNPATWEHLRIVAIVDDTYSIKSNGRRLLNPGYHAVYPYS--NATESLIPDIEDGE 473 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 L L++ T+PP R+ ++ L++ +E GIG S+ ++I + +RGY+ + R Sbjct: 474 TLRLIDSRIEAKQTQPPRRYGQSRLIETMESMGIGTKSSRHNVIQKLYNRGYIESDPPR- 532 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVL---DHFFSDFTQQ 574 ++ V + EE +++ + TAQ+E + +A E ++V +D ++ Sbjct: 533 -PTQLARAVVEAAEEFAELIVSEEMTAQLETDMQAIAEGEETLESVTSASRSILTDVFKK 591 Query: 575 LDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV-FLGCSGYALPPKERCKTT 633 L + + + R + T CP C + R + G F+GC Y C+ T Sbjct: 592 LMNTDAEIGDHLQRSMKADKTIGPCPQCEGDLITRKSQAGSHFIGCDSYP-----DCEYT 646 Query: 634 INLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE 693 + L + + C L + +H C P C+ Sbjct: 647 LPLPSTGK-------------PHILETVCDVHNLQQIKMLAGKRSFVHGC---PLCEAEA 690 Query: 694 IEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG-KYMACTN-EECKNTRKILRNGEVAPP 751 +E R+ G E+ +K R G + + CT +C+ + + R GE+ Sbjct: 691 ADEQADRVIGTCPECNAH--ADGELAIKRLRSGSRLVGCTRYPDCEYSLPLPRQGEIDVT 748 Query: 752 K------EDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRE-------TRAPLVE 798 P E + ++ L P T + +E Sbjct: 749 DNICDEHALPALQILEADENTTKDKTTKESDDIWELGC---PICNYREYQSDQTDSSTLE 805 Query: 799 ELYRFRDRLPEKLR 812 ++ + EKL+ Sbjct: 806 SVHGIGAKTAEKLK 819 Score = 66.3 bits (160), Expect = 5e-09, Method: Composition-based stats. Identities = 16/165 (9%), Positives = 39/165 (23%), Gaps = 20/165 (12%) Query: 654 NALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEK 713 A + CP+C + + C + P C+ + + Sbjct: 608 KADKTIGPCPQCEGDLITRKSQAGSHFIGCDSYPDCEYTLPLPSTGKPHILETVCDVHNL 667 Query: 714 CGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKS----DAY 769 +M G+ C A ++ C + D Sbjct: 668 QQIKMLA--GKRSFVHGCP-------------LCEAEAADEQADRVIGTCPECNAHADGE 712 Query: 770 FVLRDGAAG-VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRY 813 ++ +G + +P + + D + ++ Sbjct: 713 LAIKRLRSGSRLVGCTRYPDCEYSLPLPRQGEIDVTDNICDEHAL 757 >UniRef50_A4I3Q5 DNA topoisomerase III, putative n=8 Tax=Trypanosomatidae RepID=A4I3Q5_LEIIN Length = 867 Score = 536 bits (1382), Expect = e-151, Method: Composition-based stats. Identities = 167/853 (19%), Positives = 295/853 (34%), Gaps = 77/853 (9%) Query: 1 MGK-ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSAD----STSTKT 55 MG+ L++ E P+ A++I L + + + R LP ++ T Sbjct: 1 MGRNVLMVAEKPSLAESIATILSNGSCSRRT----RALPVYEYTGNFMGSPAYFKVTSTT 56 Query: 56 AKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDRE 115 D N D + A KV L+ ++ D + L D DRE Sbjct: 57 GHVFSCDFTSQHQNWDRTDEEQLFTAPITWKDTSGKVSHHLEHESQGCDTLVLWLDCDRE 116 Query: 116 GEAIAWHLREVIGG---DDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 GE I + + +V+ + R F+ IT I AF G+ N + +A R+ +D Sbjct: 117 GENICFEVMQVVRREIYNHHSIFRAHFSAITAEEIFHAFRNLGKPNKNISDAVTCRQELD 176 Query: 173 RVVGYMVSPLLWKKIAR--------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 VG + K +S G Q+ + V+R EI F PE FW + Sbjct: 177 LKVGVAFTRFQTKYFQGKYGDLDASVISYGPCQTPTLGFCVQRHDEILNFKPENFWRL-V 235 Query: 225 STTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLL--EKARYSVLEREDKPTTSKPGA 282 + G L + R ++ + + + +V+ T Sbjct: 236 PVASRGGALLQFEWD-----RGRLFDETMARLILQRITKSGKVATVVNVSVSNDTRPRPT 290 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGYIS 340 T L + AS LG G M +A+ LY GYI+Y RT+ST + + Sbjct: 291 GLNTVDLMKIASRALGIGPHYVMSIAENLYIRGYISYPRTESTAYPPSFNLAGALAQQKN 350 Query: 341 DNFGKKY---LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 + Y L + + H I P + + S ++ D ++++ I R Sbjct: 351 HSMWGAYVTALLQQGHARPKAGKDAGDHPPITP----MRSASPSELSGDEWRIFEYITRH 406 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 F+A + T +T+ G G+++ G+T++MP R D DR+ V+KGD Sbjct: 407 FIASVSPDCRLIKTKITIELGGELFSISGKVVEDPGFTEIMPHARVED-DRMPTGVHKGD 465 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-NRR 516 + L ++ T+PP+ +E+ L+ +EK GIG ++ ++ ++ I +RGY V+ R Sbjct: 466 SFQLSDVRLQAGQTQPPSYLTESDLIGLMEKNGIGTDASISTHVNNIVERGYCSVQAGRV 525 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS----DFT 572 K+G ++ ++ EL+ +++E + +A A+ VL + F Sbjct: 526 MKPSKLGIVLIHGIKAIDPELVLPLVRSRVEEYVTHIAEGRAQLDDVLSYSLDLFFAKFK 585 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRT--ASTGVFLGCS----GYALPP 626 + + G + + CG M + L C +ALP Sbjct: 586 FFKEHIDVFDALMGASFSAISAAGKPITRCGNCMRYLKHLDTRPQRLYCPYCEVTFALPQ 645 Query: 627 KERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDP-----KRKLH 681 K + + ++ ++ CP C + P R Sbjct: 646 GGTIKPYSSFKCPIDNFELVICH---IEGGKSFPICPHCYNNPPFEDMRPAIQHHHRGYG 702 Query: 682 V--------CGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN 733 + CD E + C M G++ C N Sbjct: 703 GGAAATTAPSTRHMACDECRHPTCEHSLATNYVCDCVDGSCAGSMAFVPRTAGQWKVCCN 762 Query: 734 EECKNTRKILRNGEVAPPKEDPVPLPELPC-----EKSDAYFVLRDGAAGVFLAANTFPK 788 +C K+ + + P C + + R +A Sbjct: 763 -KCPMMIKLPPTAQRVYVTFEECPECASNCLDIMFPEGKSVLPNRKDR---IVAC---IF 815 Query: 789 SRETRAPLVEELY 801 +PL EE+ Sbjct: 816 CHPGLSPLCEEVR 828 >UniRef50_A5FHK0 DNA topoisomerase III n=25 Tax=cellular organisms RepID=A5FHK0_FLAJ1 Length = 768 Score = 536 bits (1381), Expect = e-150, Method: Composition-based stats. Identities = 156/850 (18%), Positives = 288/850 (33%), Gaps = 137/850 (16%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 + I E P+ A+ I LG + Y V + GH+ L Sbjct: 2 KVCIAEKPSVAREIASVLGANTKHDGYYEGNGYAVTYTFGHLCTLKEPNDYKPHWKSWDL 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 P+K +E G +K +K L +KA+ + D Sbjct: 62 NNLPMLPEK-----------------FETKVVQNSGIQKQFKIIKTLFDKAELVINCGDA 104 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQQARRF 170 +EGE I + R+ + +T AI++ F+ E + A +R Sbjct: 105 GQEGELIQRWVMNEAH-YKGEIKRLWISSLTTEAIKEGFDNLKPSENYDNLFYAGFSRAI 163 Query: 171 MDRVVGYMVSPLLWKK---IARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D ++G + L K + LS GRVQ+ + +VV+R +EI+ F P+ +WE+ Sbjct: 164 GDWLLGMNATRLYTVKHGGYKQVLSIGRVQTPTLAMVVDRFKEIENFKPQPYWELQTLYR 223 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 T + + R + KE + ++++ + ++ + K F + Sbjct: 224 E----------TLFSYEEGRFLKKEDGEILAEKVKESDFEIVSVDKKNGNEYAPKLFDLT 273 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD-----N 342 LQ + + GF ++T+ +AQ LYE ITY R D+T L D V G + + Sbjct: 274 GLQVYCNQKFGFSAEETLKIAQTLYEQKAITYPRVDTTFLPGDIYPKVPGILQKLTNYSH 333 Query: 343 FGKKYLPESPNQ--YASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 + L + + + H AI P+ + + ++ + Q++Y +I ++F+A Sbjct: 334 LTEPLLGKKIKKSPKVFNDKKVTDHHAIIPTGIEI------NLPYNQQQVYDIIVKRFLA 387 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR-ILPAVNKGDAL 459 +TT+ A D KA G+ + G+ V +++ +LP+ G+ Sbjct: 388 VFYDDCLVANTTVIGKAADVTFKATGKEILKKGFRVVFEDPNAKEKEPDLLPSFVVGEKG 447 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRPSTYASIIST 503 E + Q TKPP F+EA+L++ +E + GIGRPST A+II T Sbjct: 448 -PHEPSFLQKETKPPNHFTEATLLRAMETAGKQVDDEDLRELMKENGIGRPSTRANIIET 506 Query: 504 IQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 + R Y+ ++ G + D ++ + + + T E L + A Sbjct: 507 LFKRQYIVRNKKQVLPTTTGIQLIDTIQNEL--IKSAELTGSWEKQLKDIEKGTFTAAAF 564 Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYA 623 + + + + + Sbjct: 565 IRNMKRMVEALVTEVRSETRHA-------------------------------------- 586 Query: 624 LPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVC 683 N+ + + + A CPKC + C Sbjct: 587 -----------NISHAATIQKPAVKAEKKKAAGILAETCPKCQKGNFI----KGKSAFGC 631 Query: 684 GNNPT-CDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGR--FGKYMACTNEECKNTR 740 + CD + + +K GS +++K + G E Sbjct: 632 SEYKSGCDFVLPYGFHDKKITESQYLRLVQK-GSTVNIKGFKTDAGTVEGLIRFEENYKL 690 Query: 741 KILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 K+ L C K +L+ G + + + + E Sbjct: 691 KLEPKKTYIKKTTKETASDSLSCPKCKKGNILK-GKTA--YGCSEYKSGCDFKVTFDEVR 747 Query: 801 YRFRDRLPEK 810 + +D+ P K Sbjct: 748 AKLQDQKPTK 757 >UniRef50_A6BK25 DNA topoisomerase n=12 Tax=Firmicutes RepID=A6BK25_9FIRM Length = 765 Score = 536 bits (1380), Expect = e-150, Method: Composition-based stats. Identities = 157/767 (20%), Positives = 275/767 (35%), Gaps = 135/767 (17%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LV+ E P+ A+ I + LG S+Y+V ++GH+ L KK Sbjct: 2 KSLVLAEKPSVARDIARVLGCHKNISGAIEGSNYIVTWALGHLVTLADPEEYDKKFKAWD 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIYLA 109 + PK + V+ K +K + I +A Sbjct: 62 MSYLPMVPK-------------------KWELVVIKQTSKQYHNVKTQLFRKDVSEIIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQA 167 TD REGE +A + + G R+ + +T AI++ F + D +A ++ Sbjct: 103 TDAGREGELVARWILDKSGC-HKPIRRLWISSVTDKAIKEGFAHLKDGRAYNDLYHAARS 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D +VG + L K LS GRVQ+ + ++ RE++I++F PE+++ + +T+ Sbjct: 162 RAEADWLVGINATRALTCKYNAQLSCGRVQTPTLAMIAHREQQIRSFKPEDYYGLRCTTS 221 Query: 228 TPSGEA------LALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 G + + R NK+ L+ +V + + Sbjct: 222 VTGGSVGTMASIVTWTWQQKKSGSLRSFNKDLITGLDKKLKNQTLTVTDVHTSSKRTPSP 281 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYIS 340 + + LQ+ A+ R GF K+T+ + Q LYE + TY RTDS + D V ++ + Sbjct: 282 GLYDLTELQRDANKRFGFSAKETLNIMQSLYEHHKVLTYPRTDSRYIGTDIVPTIKERLK 341 Query: 341 -------DNFGKKYLPESPNQYA--SKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLY 391 + + L + + H AI P++ V E M + +K+Y Sbjct: 342 ACNIGPYKKYIPELLKKPLKTSKAFVDDKKVSDHHAIIPTEEYVQMEH---MSNNERKIY 398 Query: 392 QLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKV-------------- 437 L+ R+F++ +Y+ TTL A A+G++++ GW V Sbjct: 399 DLVVRRFISVLYPAFEYEQTTLKAEAAGETFTAKGKVIKAAGWKAVYADAASSGSSASQY 458 Query: 438 --MPALRKGDE---------------DRILPAVNKGDALTLVELTPAQHFTKPPARFSEA 480 ++ ++ LP ++KGD LT+ TK PARF+EA Sbjct: 459 DAYGDYEDSEDFGEDFQNNDMYLKASEQALPVLHKGDTLTVTRTNITSGKTKAPARFTEA 518 Query: 481 SLVKELEK-------------------RGIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521 +L+ +E G+G +T A II + + + Sbjct: 519 TLLSAMENPVRYMSSDDNKMKKTLGETGGLGTVATRADIIEKLFHSFLLEKKGNEILLTS 578 Query: 522 MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 G+ + + + E +L + TA E L ++A + + + S + + Sbjct: 579 KGKQLLELVPE---DLKKPELTASWEMELAKIAKGAHKEQVFIKDIESYTKELIQDI--- 632 Query: 582 PEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENE 641 + LT+ CP CG++M L C C Sbjct: 633 -KTSDGTFRHDNLTNTKCPHCGKRMLSVKGKNSRMLVC------QDRECGY--------- 676 Query: 642 VLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPT 688 ET A + RCP C M+ Sbjct: 677 ---------RETIARTSNARCPNCHKKMELIKKGDSETFVCSCGYKE 714 Score = 43.9 bits (102), Expect = 0.026, Method: Composition-based stats. Identities = 12/89 (13%), Positives = 28/89 (31%), Gaps = 14/89 (15%) Query: 701 IKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPE 760 + + +C CG M G+ + + C + EC +E Sbjct: 639 FRHDNLTNTKCPHCGKRMLSVKGKNSRMLVCQDRECGY-------------RETIARTSN 685 Query: 761 LPCEKSDAYF-VLRDGAAGVFLAANTFPK 788 C +++ G + F+ + + + Sbjct: 686 ARCPNCHKKMELIKKGDSETFVCSCGYKE 714 >UniRef50_A3BAP2 DNA topoisomerase n=6 Tax=Poaceae RepID=A3BAP2_ORYSJ Length = 1180 Score = 535 bits (1378), Expect = e-150, Method: Composition-based stats. Identities = 249/969 (25%), Positives = 392/969 (40%), Gaps = 203/969 (20%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K++++VES KAK I KYLG Y V S GH+RDL Sbjct: 295 AKSVLVVESVTKAKVIQKYLGDMYEVLPSYGHVRDLAGRSK------------------- 335 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK------ADHIYLATDLDRE 115 V P ++ +EV + ++ + A+++ LA+D DRE Sbjct: 336 ----------SVRPDDDFSMVWEVPAAAWTHLKSIRTALKGYDNAVWAENLILASDPDRE 385 Query: 116 GEAIAWHLREVIG-----GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRF 170 GEAIAWH++E++ G +RVVF+EIT++A+++A P +++D VNA ARR Sbjct: 386 GEAIAWHIKEMLEQQDALGSKVTVARVVFHEITEDAVKKALISPRYIDMDLVNAYLARRS 445 Query: 171 MDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT-- 228 +D ++G+ +SPLLW+K+ SAGRVQS A+ LV +RE EI+ F P+E+W VD T Sbjct: 446 LDYLIGFGISPLLWRKLPGCQSAGRVQSAALALVCDREAEIEQFDPQEYWTVDTDFKTQH 505 Query: 229 ---PSGEALALQVTHQNDKPFR---PVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 +G L ++ H N K ++E+ + +++ V + P Sbjct: 506 SGPSNGLNLQSRIKHLNSKKLDQLSIRSQEEAHNIEKRIYSSQFEVTGIKRSKINKNPPM 565 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEA---------GYITYMRTD---------- 323 P+ITS+LQQ A+ +L F TM +AQ+LYE G ITY+RTD Sbjct: 566 PYITSSLQQDAANKLHFSAGYTMKVAQKLYEGINLSSEEATGLITYIRTDGFHWYQSARG 625 Query: 324 -------------------------------------------STNLSQDAVNMVRGYIS 340 S +S A + + Sbjct: 626 QCVFLCSRVRGGIEEALACLACEQLSAAQATIIAAHDNRIVANSIFISDGAAEDILSLVK 685 Query: 341 DNFGKKYLPESPNQYASK-ENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQF 398 +G++Y E +Y K +N+QEAHEAIRP+ + + SL ++ D+ KLY LIW++ Sbjct: 686 QRYGEEYASEGIRKYFKKVKNAQEAHEAIRPTSIRRLPSSLVGALDDDSLKLYTLIWKRT 745 Query: 399 VACQMTPAKYDSTTLTVGA--GDFRLKARGRILRFDGWTKVMPALRKG------------ 444 +ACQM ++ D + +G GD + L F G+ V Sbjct: 746 MACQMEASRTDMIQVDIGNSEGDMIFHSSASRLDFKGYQAVYDDTEASPSSYNSEVDAVH 805 Query: 445 -DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIIST 503 D L + D ++ V + +QHFTKPP+R+SE++L+K+LE+ GIGRPSTYASI+ Sbjct: 806 QDNFEALSKLEVKDLVSPVNVHLSQHFTKPPSRYSESALIKKLEELGIGRPSTYASIMKV 865 Query: 504 IQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 +QDR YV +++R + E G +V+ L +F E+ + FTA ME LD V+ EWK + Sbjct: 866 LQDRKYVTIKSRVLHPEFRGRMVSAFLMHHFSEVADLSFTANMETELDNVSAGSTEWKGL 925 Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYA 623 L F+ F + A + R + ++ + P +M G L Sbjct: 926 LKDFWERFNKYCGDASRLDVRKVERKSLLISHKVQLPLKVERML--EEKFGSIL------ 977 Query: 624 LPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK--RKLH 681 ++ R CP C + + Sbjct: 978 ----------------------------FSDLDNDSRICPSCSEGTLRFKVSRYGEGYFI 1009 Query: 682 VCGNNPTCDGYEIEEGEFRIKGY----------DGPIVECEKCGSEMHLKMGRFGKYMAC 731 C +P C + + + ++ LK G +G Y+ Sbjct: 1010 GCDRHPKCKYIARTLSDDDDETEASDETQRTFTPRLLGALPDSDEKVFLKQGPYGHYVQV 1069 Query: 732 TNEECKNTRKILRNGEVAPPKE---------DPVPLPELPCEKSDAYFVLRDGAAGVFLA 782 + + K EV P D ++ AG Sbjct: 1070 GEDRKGVSPKRAPLSEVKDIDSITLKDAIELLQYPKILGKHPDDDLPVLITHSKAGF--- 1126 Query: 783 ANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSS 842 + R T A L + + L L+ L K + F R + + Sbjct: 1127 ---SIRHRRTLASLPKSADPKKITLERALKLLT---------GKNVRMFGRPKGK----T 1170 Query: 843 EKDGKATGW 851 +K+ + W Sbjct: 1171 KKEAEPLEW 1179 >UniRef50_C0A759 DNA topoisomerase n=4 Tax=Bacteria RepID=C0A759_9BACT Length = 817 Score = 535 bits (1377), Expect = e-150, Method: Composition-based stats. Identities = 160/836 (19%), Positives = 288/836 (34%), Gaps = 155/836 (18%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 +V+ E P+ A+ I K+LG + + V + GH+ +L + Sbjct: 2 KVVLAEKPSVARDIAKHLGATKRGVGFLEGNGWAVTWAFGHMVELQEPEDYKPEWKAWRL 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P + + +K+L AD I ATD Sbjct: 62 STLPIIPADFALRPRASD--------------PDGTARAQLETIKKLFLDADEIICATDA 107 Query: 113 DREGEAIAWHLREVIGGDD------ARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNA 164 REGE I ++ G + R+ + +T AI + F PG +A Sbjct: 108 GREGELIFRYIYTWTGCEALPPPLAKPVRRLWISSLTNEAIEKGFQNLAPGSDYDRLYHA 167 Query: 165 QQARRFMDRVVGYMVSPLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 + R D +VG + + R LS GRVQ+ + ++V R+ +++ F PE+FWE Sbjct: 168 ARCRSEADWIVGLNATRFFTVEYGRRNLLLSLGRVQTPILAMIVGRDLDVEHFKPEDFWE 227 Query: 222 VDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 V + + + A + T Q + QA V + + K + P Sbjct: 228 VHTLCRSATFKHTAGKFTVQ----------TEAQAIVDRITGHELVIKNVTKKNALTHPP 277 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD-------AVNM 334 + + LQ+ + R G +T+ +AQ LYE+ ++TY RTDS LS D ++ Sbjct: 278 LLYDLTGLQRDMNKRHGLTADQTLRLAQSLYESKHLTYPRTDSCYLSTDIQPTIGPLLDR 337 Query: 335 VRGYISDNFGKKYLPE-SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 +R GK + ++ + H AI P++V D+ D K+Y Sbjct: 338 LRALKPAEIGKLDTGALAFSKRIIDDKKVSDHHAIIPTNVLG-----GDLTGDEAKVYDA 392 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE------- 446 + + +A P TT+ + +ARG +L GW + D+ Sbjct: 393 VLTRLIAVFYPPCIKAVTTVEAESAGEPFRARGTVLVDPGWQALYGGDVSDDDAGTGTKA 452 Query: 447 ------------------------------DRILPAVNKGDALTLVELTPAQHFTKPPAR 476 + LP +G+ E + Q T P R Sbjct: 453 KKASKNAAKKDADENESGESDAKDSDAADSAQQLPDFQEGER-NPHEPSLPQFKTSAPKR 511 Query: 477 FSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 F+EASL++ +E +G+G P+T A+II + RGYV + + + Sbjct: 512 FNEASLLQLMETAGKIVTDETLKEALKDKGVGTPATRAAIIEVLITRGYVERKKKNLIST 571 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK 580 G + +++ L + + T E L Q+ E E + + + + L Sbjct: 572 DSGRALISLVQD--ERLKSPELTGDWEYRLRQIERGEYEPRVFMSEVEAYTREILKN--- 626 Query: 581 DPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL---- 636 + CP C + TG GCS + + CK + Sbjct: 627 -----RAEQTINLSNLGPCPACHAPVM--RGRTG--YGCSQW----RGGCKFVLPGDYLG 673 Query: 637 --VPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEI 694 + +L + ++ P C + + +D K +++ Sbjct: 674 LTITPVLAREILIHKHTLAPQPVVIKQSP-C---LATLRLDKKGA----------LTHDV 719 Query: 695 EEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAP 750 + + + C CG ++ + +G C+N + + Sbjct: 720 VQQVNKAGEGSDTLGRCPACGGDIVAGVKAYG----CSNWRNGCRFVVWKTIAQKE 771 >UniRef50_P78032 DNA topoisomerase 1 n=2 Tax=Mycoplasma RepID=TOP1_MYCPN Length = 711 Score = 534 bits (1375), Expect = e-150, Method: Composition-based stats. Identities = 215/744 (28%), Positives = 352/744 (47%), Gaps = 83/744 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTS------GSAAKKSADSTSTK 54 M K LV++ESP K KT+ KYL +D+ + S++GHIR++ + D T +K Sbjct: 1 MSKNLVVIESPNKVKTLQKYLPNDFEIVSTIGHIREMVHKNFGFNEADYSPVWEDWTKSK 60 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 + ++ K ++ +K+ A KA +IYLATD DR Sbjct: 61 KKFSSLSFKGNLKGKKLL---------------SKYDIIKSIKEKASKATNIYLATDPDR 105 Query: 115 EGEAIAWHLREVIGGDDA-RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 EGEAI+WH+ +V+ D + R+ FNEITKNA+ A P E++ V +Q AR+ +DR Sbjct: 106 EGEAISWHVYDVLDEKDKSKCQRITFNEITKNAVLDALKNPREIDQSWVQSQFARQILDR 165 Query: 174 VVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS--- 230 ++G+ +S LL ++ SAGRVQSVA+R + ERE+EI++FVP +W +D + Sbjct: 166 MIGFRLSRLLNNYLSAK-SAGRVQSVALRFLEEREQEIRSFVPRFWWTLDVLLNPKAEGV 224 Query: 231 ----------------GEALALQVTHQNDK---PFRPVNKEQTQAAVSLLEKARYSVLER 271 AL + + +K +++ + L+ Sbjct: 225 REACANRSIPIVLREINPALRAGLKFEEEKSVSGIDFLDEASAKKFGEQLKGVFEVYNID 284 Query: 272 EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTD 323 E K +S P + + T++LQ+ A +LG+ KK ++AQ LYE I+Y RTD Sbjct: 285 ETKHYSSSPNSAYTTASLQKDAINKLGWSSKKVTLIAQHLYEGVSINGEQTALISYPRTD 344 Query: 324 STNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENS---QEAHEAIRPSDVNVMAESL 380 ST LS + YI +++G+KYL K+ Q+AHEAI P+D+N+ E + Sbjct: 345 STRLSAQFQQSCKEYILNHYGEKYLSNRIVSAKGKKGEKIIQDAHEAIHPTDINITPEMV 404 Query: 381 KD-MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP 439 K+ ++ D LY+LIW + VA M K T + + A + L FDG+ K+ Sbjct: 405 KNAIKKDEFLLYRLIWIRTVASLMADCKKSHTHIRFINDGNKFYASSKSLVFDGYRKIYE 464 Query: 440 ALRKGDEDRI---LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPST 496 + + + L + GD ++ T P AR+++ASL++ LEK IGRPST Sbjct: 465 HFENKESNDLYIDLDKIRVGDRFMAKDIKITARQTHPAARYTQASLIEALEKSNIGRPST 524 Query: 497 YASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 Y ++ S DRGY + F+ ++GE V + L ++F +++N +FT ME SLD++A + Sbjct: 525 YNTMASVNLDRGYASLNKHAFHVTQLGEQVNEELSKHFGKIINKEFTKNMEKSLDEIAEN 584 Query: 557 EAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG-- 614 + ++ L F+S+F +++ AE + + DCP+C + R G Sbjct: 585 KKNYQEFLRDFWSNFKEEVKLAEGSIQRVKKEKEFV---GRDCPSCASPLLYRYTKRGNE 641 Query: 615 VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLI 674 F+GCS + + ++ + CP+C + + Sbjct: 642 KFVGCSNFPNCKYNEFSQNKPNLTLEKLEEL----------------CPECNSQLVKRRT 685 Query: 675 D--PKRKLHVCGNNPTCDGYEIEE 696 P + C N P C + + Sbjct: 686 KFNPNKTFVGCSNFPRCRYIKKDN 709 >UniRef50_B9LRP1 DNA topoisomerase n=4 Tax=Halobacteriaceae RepID=B9LRP1_HALLT Length = 864 Score = 533 bits (1374), Expect = e-150, Method: Composition-based stats. Identities = 208/861 (24%), Positives = 346/861 (40%), Gaps = 106/861 (12%) Query: 1 MGK--ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 M + L+I E A+ I L + + + K + Sbjct: 1 MSRGPELIITEKDNAARRIADILSGESATA-------ERENDVNVYKWGGKRCIGLSGHV 53 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEA 118 D + V+P +A P +E +V+ L++LA A + +ATD DREGE Sbjct: 54 VGVDFPAEYNDWRDVEPVELIDAPITKEPTQEGIVAALRKLARNASRVVIATDYDREGEL 113 Query: 119 IAWHLREVIGGDDA--RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVG 176 I E++ + RV F+ IT N + +AF P EL+ D A +AR+ +D G Sbjct: 114 IGKEAYELVREVNEDAPIDRVRFSSITDNEVNEAFANPDELDFDLAAAGEARQVIDLTWG 173 Query: 177 YMVSPLLWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE 232 ++ L + +S GRVQ ++L+V+REREIKAF PE +WE+ + T G+ Sbjct: 174 AALTRFLSLSARQLGEDFISVGRVQGPTLKLIVDREREIKAFDPEAYWELYGNLTKSGGD 233 Query: 233 ALALQVTHQND---KPFRPVNKEQTQAAVSLLEKA-RYSVLEREDKPTTSKPGAPFITST 288 + + ND + R N + + + A V + + T P PF T+ Sbjct: 234 PFEARYFYLNDEGNEAERVWNGDVAEVLTEAFDAADEAVVDDVRRRTRTDDPPTPFNTTA 293 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGY-ISDNFGK 345 +AA + LG ++ M +A+ LY AGY+TY RTD+T +D ++ ++ FGK Sbjct: 294 FIRAAGS-LGHSAQRAMSLAEDLYTAGYVTYPRTDNTVYPEDLDPRELIEELSVASTFGK 352 Query: 346 K---YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQ 402 L + + + H I P+ S D+ D ++Y+LI R+F+A Sbjct: 353 DAKSLLEQEEIEPTEGDEETTDHPPIHPTG---ELPSASDLSEDEWEVYELIVRRFLATC 409 Query: 403 MTPAKYDSTTLTVGAGDF--------------------------------RLKARGRILR 430 PA ++ + A D RLKA G+ L Sbjct: 410 AEPATWERLRVVALANDEATAIAERADGLAALRNPEEASGPGDLVADGGLRLKANGKRLL 469 Query: 431 FDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRG 490 G+ V P + ++RI+P V G+ L L + T+PP R+ ++ L++E+EKRG Sbjct: 470 EAGYHDVYPY--RSSDERIVPDVEVGETLALTDRRTDAKETQPPRRYGQSRLIEEMEKRG 527 Query: 491 IGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSL 550 +G +T + + DR Y+ + R ++ E V + EE +++ + TAQ+E + Sbjct: 528 VGTKATRHRTLEKLYDRNYIESDPPR--PTRLAEAVVEAAEEFAEHVVSEEMTAQLERDM 585 Query: 551 DQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM---VLTSIDCPTCGRKMG 607 +A E + V + + D + E G + T CP CG + Sbjct: 586 QAIAAGEKGYDEVTEASRELLNRVFDDLTESREAVGDHLQKSLKADKTLGPCPECGSDLL 645 Query: 608 IRTASTG-VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 +R + G F+GC GY C+ T+ L + L + E C + Sbjct: 646 VRKSRQGSYFVGCDGYP-----DCEYTLPLPSSGKPLLLDET-------------CEEHE 687 Query: 667 TAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG 726 L K +H C P C E +E E + G E+ G E+ +K R G Sbjct: 688 LRHVKMLAGRKTFVHGC---PQCKADEADEQEDEVIGACPEC--GEEHGGELAIKRLRSG 742 Query: 727 -KYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVF-LAA 783 + + CT +C + + R GE+ + + CE+ + + L Sbjct: 743 SRLVGCTRYPDCDYSLPLPRRGEI--------EVTDEICEEHGLPHLRVHSGDEPWELGC 794 Query: 784 NTFPKSRETRAPLVEELYRFR 804 P +E + Sbjct: 795 ---PICNYREFTARQEGSELQ 812 Score = 77.5 bits (189), Expect = 2e-12, Method: Composition-based stats. Identities = 23/165 (13%), Positives = 42/165 (25%), Gaps = 20/165 (12%) Query: 654 NALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEK 713 A + CP+CG+ + C P C+ + D E E Sbjct: 629 KADKTLGPCPECGSDLLVRKSRQGSYFVGCDGYPDCEYTLPLPSSGKPLLLDETCEEHEL 688 Query: 714 CGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD----AY 769 +M GR C +CK A ++ C + Sbjct: 689 RHVKMLA--GRKTFVHGC--PQCK-----------ADEADEQEDEVIGACPECGEEHGGE 733 Query: 770 FVLRDGAAG-VFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRY 813 ++ +G + +P + D + E+ Sbjct: 734 LAIKRLRSGSRLVGCTRYPDCDYSLPLPRRGEIEVTDEICEEHGL 778 >UniRef50_D0L167 DNA topoisomerase n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0L167_HALNC Length = 680 Score = 533 bits (1374), Expect = e-150, Method: Composition-based stats. Identities = 146/705 (20%), Positives = 256/705 (36%), Gaps = 84/705 (11%) Query: 5 LVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 + + E P++A+ I LG +D VV + GH+ + + Sbjct: 3 VYLCEKPSQARDIAAVLGIQSKDKSSITTADGVVTWAFGHLLEQAPPDAYDDSLKRWALA 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 P + EV + + L ++A + +ATD D Sbjct: 63 SLPIAPT-------------------QWKVEVKSSAKDQFKAIATLLKRATEVVIATDAD 103 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFM 171 REGE IA L +G + R+ + + ++++A KP + R Sbjct: 104 REGEMIARELMAFVGF-KGKVQRLWLSALDAASVKKALAALKPSAETAGLYQSALGRSRA 162 Query: 172 DRVVGYMVSPLLWKK-----IARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D +VG ++ S GRVQ+ + LVV R+R+I+ F P ++E+ Sbjct: 163 DWLVGMNLTRAFTLAGCSQGGEGVRSVGRVQTPTLSLVVARDRQIEHFKPVPYFELFGFF 222 Query: 227 TTPSGEALALQVTH-QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 + +V D R V++ A S + +V + E K + P PF Sbjct: 223 EAGQSFSTKWKVPEGAGDDAGRCVDQSIVDAVASKITGKTGTVSQYETKRISENPPLPFS 282 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDNFG 344 STLQ+ S + G G ++ + +AQ LYE TY R+D L ++ ++ Sbjct: 283 LSTLQKTCSAKFGLGAQEVLDIAQALYETHKATTYPRSDCNFLPEEQFQEASSIVTALAK 342 Query: 345 K--------KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWR 396 L S A AH AI P+ ++ M + +++Y+LI R Sbjct: 343 SDTEVQGIVDLLDFSRKSPAWNTKKITAHHAIIPTQ---TPPNMDAMSDNERRVYELIRR 399 Query: 397 QFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP-----ALRKGDEDRILP 451 Q++A + +YD T + + + G+I + GW + DE + LP Sbjct: 400 QYLAQFLPNYEYDRTQIGISIEGELFQTTGKIDQVTGWRVLFGKADASDDEPDDEVQTLP 459 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRP 494 A+ +G L L A TKPP+R++E +L+ + E GIG Sbjct: 460 ALTQGQTLPLSHTEIAAKQTKPPSRYTEGTLIDAMQTIGKNITDPRLKAILKENSGIGTE 519 Query: 495 STYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 +T A II+ + +RG++ + ++ + +G + D L + + + TA E SL+++A Sbjct: 520 ATRAGIIANLIERGFITKKGKQVISSDVGRQLIDALPD---SVKSPALTALWEQSLEEIA 576 Query: 555 NHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG 614 + E T +D+ +K + + Sbjct: 577 EGKRELAGFEADVVKFITAIIDQIKKQHADAPAPTRPTADCPTCKAQGQAEKVYSIKKQC 636 Query: 615 VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAK 659 + C C + V A R K Sbjct: 637 HYWHCKA--------CNQWFDDAAGKPVPKAAASSSKTKPAPRKK 673 >UniRef50_B1M9R9 DNA topoisomerase I n=4 Tax=root RepID=B1M9R9_METRJ Length = 788 Score = 533 bits (1374), Expect = e-150, Method: Composition-based stats. Identities = 232/811 (28%), Positives = 355/811 (43%), Gaps = 84/811 (10%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L++VESP K +I YLG D+ V +S GHIRDLP D + P+K Sbjct: 2 KLMVVESPNKVASIQGYLGDDWKVVASSGHIRDLPQRE-FGISKPDFSLQYEYIPPQKVG 60 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 + PG V+ +K+ KAD +YLATD DREGEAI+WHL Sbjct: 61 N-------------------KTFPGAADRVARIKREVAKADAVYLATDPDREGEAISWHL 101 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 +E + + Y RV F EIT AI+ A +++D V+AQ+ RR +DR VGYMVSPLL Sbjct: 102 KEALQLGEDDYERVTFTEITPKAIQAALRAARRIDMDLVHAQEGRRALDRFVGYMVSPLL 161 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 + LSAGRVQSVAVRLVV+ ER I AF + + + +G + Q + Sbjct: 162 SDMLGMNLSAGRVQSVAVRLVVDLERRIAAFKSTKHFSAVVTFDAGAGAKWSAQWDTKPY 221 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 A + ++ VLE + + + +P +P T + +AAST L Sbjct: 222 VTEDSPYVLDEALAAKASQSRQFVVLESKTEEKSERPPSPLSTLGMLRAASTALKMSSAA 281 Query: 304 TMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQE 363 T AQ+L+E G+ITY+RTDS NLS DA + VR + + L ++ K ++Q Sbjct: 282 TTKAAQKLFEDGHITYIRTDSVNLSPDAADKVRSFAASQ--GMALSPEVRRWKEKASAQG 339 Query: 364 AH-EAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA---GD 419 H +A+RP+ + V + + LY+LI + + QM A+Y T+ + A Sbjct: 340 GHADAVRPTHIEVEDAGA---DDAQRALYRLIRLRTLVSQMADARYTVNTVRLRATDRDG 396 Query: 420 FRLKARGRILRFDGWTKVMPALRKGDEDR--------ILPAVNKGDALTLVELTPAQHFT 471 F ARGR + GW ++ +E+ +P + G L ++ T Sbjct: 397 FEYVARGRKMIDAGWRALLERDPDEEENSDDDAAKDGQVPRLAVGGDLRAIDGKVLDKKT 456 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR-FYAEKMGEIVTDRL 530 +PP RF+EA+L+++LE G+GRP+T+A+I++ + R YV ++ +R ++GE+V D L Sbjct: 457 EPPRRFTEATLLQKLEDEGVGRPATFAAIMTNVLGRSYVELDKKRCLLPTEIGELVVDNL 516 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 M FT ++E LD +A +A ++ V++ + ++L + E Sbjct: 517 LRGQFGFMELGFTRELEVQLDAIAEGKASYRDVVEPAYRQLNEELARIAVSGEF------ 570 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGV--FLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 CP CG M R A G F C+ E E Sbjct: 571 ---TPRFKCPKCGTGM-RRYAKPGKSPFWRCTA-----------------EAETCGHYMD 609 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 +D R CP+CG + + L C+ + + G + + Sbjct: 610 DDKGKPVERTAHPCPRCGETLRRFKRKNGGGLVWVCPAEACETFLDDVGGKPVALHTCTK 669 Query: 709 VECE-----KCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 K E G FG + CT+ E CK + PV + P Sbjct: 670 CNAPLRRYQKKDRETGKPTGAFGWF--CTDTENCKTFMDDDKG--------RPVAIKTAP 719 Query: 763 CEKSDAYFVLRDGAAGVFLAANTFPK-SRET 792 C K R G G + + + + + Sbjct: 720 CPKCGKAMYRRKGDHGFWWGCSGYREGCKTI 750 >UniRef50_D2LPU9 DNA topoisomerase I n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LPU9_9EURY Length = 764 Score = 533 bits (1374), Expect = e-150, Method: Composition-based stats. Identities = 172/809 (21%), Positives = 317/809 (39%), Gaps = 75/809 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 LVI E A+ I K L G + + D Sbjct: 19 NILVIAEKRNAAQRIAKILSGGRYETIKKGRNAYYSFTKGKDRYFVVPLRGHILHMDYPD 78 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 + +G E +++ K + + L+ LA+ AD + +ATD DREGE I Sbjct: 79 KF--KRWSLGDLQRLVDEEPIKIIKEKG-IANILRTLAKDADMLIIATDYDREGELIGVE 135 Query: 123 LREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 I R F+ +T+ I AF+ ++N + +A + R+ +D G ++ Sbjct: 136 SLS-ITNFKGPVKRAKFSALTEREIENAFSNLVDVNYNLASAAETRQKIDLAWGASLTRF 194 Query: 183 LWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 + +R LS GRVQS + L+V+RE+EI+ FVP +W + + Sbjct: 195 ISLASSRRGKDYLSVGRVQSPTLALIVKREKEIENFVPTPYWNIKGLFFKRRNFSGMHIS 254 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 + +E + + + VL+ + +P PF T+ A T+LG Sbjct: 255 NPFWKE------EEVMEVYEKVKDTKSAKVLDFVQEDRKIRPPIPFNTTEFLSEA-TKLG 307 Query: 299 FGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV--NMVRGYISDNFGKKYLP---ESPN 353 F K M +A+ LY GYI+Y RTD+T + ++++ F ++ L E Sbjct: 308 FSAAKAMRLAEELYMGGYISYPRTDNTVYPKTLSINSILKSLEKSKFKEEALKLQKERRR 367 Query: 354 QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTL 413 + H I P+ ++E D K+Y+L+ R+F+A +Y + + Sbjct: 368 YPTRGKKESTDHPPIVPTRG-------ANLEGDKGKIYELVVRRFMATLAQDLEYRESKV 420 Query: 414 TVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKP 473 + D +A+G+ L +GW P +R +E +P + GD + + ++ + T+P Sbjct: 421 KLAVKDEIFEAKGKELVNEGWLYYYPYVRFEEEK--IPILRIGDEVKVKKIEIERKETRP 478 Query: 474 PARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEEN 533 PAR++++SL++E+EK +G ST A II + +RGYV ++G+ + + LE N Sbjct: 479 PARYTQSSLIREMEKLNLGTKSTRAEIIQKLFERGYV--RGNPIRPTQLGKALIESLEGN 536 Query: 534 FRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMV 593 +++ D TA++E +D++ + V+ + L E++ G + Sbjct: 537 NVDVIKPDMTARLEMDMDEIEKGSKAPEFVVKESREMLKKILSSLEENRSTVGSNIKSSM 596 Query: 594 LTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAET 653 I G K+ + C + Sbjct: 597 RREIGECPDGGKLIYLERK--RLVVCEN-------------------DGETKYYNLPKTG 635 Query: 654 NALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEK 713 + ++CP CG + + + C N+ C+ ++ + +C K Sbjct: 636 HIEFLDKKCPICGLPLIKIIRRGQSPEIRCLNS-KCEYNRKKDI----------VGKCPK 684 Query: 714 CGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY-F 770 CG ++ ++ + GK ++ C+N +C T + + G++ P C A Sbjct: 685 CGGDLVIRQSKNGKRFIGCSNYPKCDVTYSLPQRGKIIPT--------GEVCPYCGAPLL 736 Query: 771 VLRDGAAGVFLAANTFPKSRETRAPLVEE 799 +LR + K R E+ Sbjct: 737 ILRKKGKKDWKFCPN-IKCEYNRRNKDEK 764 >UniRef50_B1VAJ5 DNA topoisomerase n=6 Tax=Acholeplasmataceae RepID=B1VAJ5_PHYAS Length = 655 Score = 533 bits (1372), Expect = e-149, Method: Composition-based stats. Identities = 223/710 (31%), Positives = 355/710 (50%), Gaps = 67/710 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K ++IVESPAK KT++++ + SS GHIRDL SG Sbjct: 1 MKKKVIIVESPAKIKTLSRFFDDKVEILSSKGHIRDLSLSG------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +R+G+D + + YE++ K+ +V L + + I+LATD DREGEAIA Sbjct: 42 -------KDRLGIDIKNGFIPKYEIIKEKKTLVESLIKKTKN-KEIFLATDPDREGEAIA 93 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL +V+ + +R+VF EITK + +A P ++ V +Q+ RR +DR++G+ +S Sbjct: 94 WHLSKVLNLNPQMANRIVFREITKEVVLKALQNPRTVDELLVFSQETRRMLDRIIGFKLS 153 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 L+ + ++ SAGRVQSVA++L+V+ E+EI +FVPEE+ + A + + Sbjct: 154 RLVRRIKSQ--SAGRVQSVALKLIVDLEKEINSFVPEEYNLITAFF-----PFFQAEYQN 206 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 N+K + + V+ + + V + + T SKP P ITSTLQQ A L Sbjct: 207 PNNKKIKS---AEALGIVAKITNKPFIVKKIKQTETFSKPKKPLITSTLQQEAINNLYMT 263 Query: 301 VKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESP 352 +TM +AQ+LYE G ITYMRTDS S+ V + I + +G+KYL + Sbjct: 264 SNQTMRVAQKLYEGIDIEGESIGLITYMRTDSPRFSEVFVKDAQKLIKEKYGQKYL--AV 321 Query: 353 NQYASKENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 + K +Q+AHEAI+P+D++ ESL ++ KLY LI+++ +A M PA + Sbjct: 322 FKQNQKNKAQDAHEAIKPTDLSKTPESLMSYLDKYEYKLYDLIYKRSLASLMKPAIFQKN 381 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + G I FDG+ K++ + +D+I+P N ++ ++ Q FT Sbjct: 382 QVFFEVEKHSFLTEGLIKTFDGYQKIL---KDNLQDKIIPTFNLNESYFPEKIETFQKFT 438 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 P ARFSEA+L+K LEK IGRPSTY+ II T++ R YV + +RF + G + LE Sbjct: 439 TPQARFSEATLIKTLEKLNIGRPSTYSQIIFTLKKRFYVDMIEKRFQPTEQGILTIQNLE 498 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 F++ ++Y +TAQME+ LD++A+ + K ++ F+++F Q A++ E+ Sbjct: 499 LFFKQFLDYQYTAQMESDLDKIASGLVDNKQLMQTFYTNFLQLYQIADQKLEKIKP---- 554 Query: 592 MVLTSIDCPTCGRK-MGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 + T C C + I+ + G FLGCS + CK T + + + Sbjct: 555 -IETDQKCNLCNEGNLLIKKSHYGSFLGCSRFP-----DCKNTSPWKVQEKNKSKDSDHS 608 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFR 700 + ++C C C P C + + Sbjct: 609 NQ-----TDQKCNLCNEGNLLIKKSRYGSFLGCSRFPDCKNIVKIKNKPN 653 Score = 71.7 bits (174), Expect = 1e-10, Method: Composition-based stats. Identities = 16/110 (14%), Positives = 36/110 (32%), Gaps = 3/110 (2%) Query: 696 EGEFRIKGYDGPIVECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKE 753 + + +C C + +K +G ++ C+ +CKNT + Sbjct: 546 DQKLEKIKPIETDQKCNLCNEGNLLIKKSHYGSFLGCSRFPDCKNTSPWKVQEKNKSKDS 605 Query: 754 DPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYR 802 D + C + +++ G FL + FP + + + Sbjct: 606 DHSNQTDQKCNLCNEGNLLIKKSRYGSFLGCSRFPDCKNIVKIKNKPNSK 655 Score = 53.2 bits (126), Expect = 5e-05, Method: Composition-based stats. Identities = 12/93 (12%), Positives = 27/93 (29%), Gaps = 4/93 (4%) Query: 745 NGEVAPPKEDPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRF 803 ++ + C + +++ G FL + FP + T V+E + Sbjct: 543 QIADQKLEKIKPIETDQKCNLCNEGNLLIKKSHYGSFLGCSRFPDCKNTSPWKVQEKNKS 602 Query: 804 RDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 + D +++ SR Sbjct: 603 K---DSDHSNQTDQKCNLCNEGNLLIKKSRYGS 632 >UniRef50_A0R979 DNA topoisomerase 3 n=95 Tax=Bacteria RepID=TOP3_BACAH Length = 729 Score = 532 bits (1371), Expect = e-149, Method: Composition-based stats. Identities = 162/737 (21%), Positives = 287/737 (38%), Gaps = 111/737 (15%) Query: 1 MGKALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M K++VI E P+ A+ I + L GS Y+V ++GH+ L S K Sbjct: 1 MAKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKK 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIY 107 + P V+ K + +K + + I Sbjct: 61 WN-------------------LEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEII 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQ 165 +ATD REGE +A + + + + R+ + +T AI+ F PG+ + + Sbjct: 102 VATDAGREGELVARWIIDKVRI-NKPIKRLWISSVTDKAIKDGFANLKPGKAYDNLYASA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D +G + L + L+ GRVQ+ V ++ RE EIK F + ++ ++A Sbjct: 161 VARSEADWYIGLNATRALTTRFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQ 220 Query: 226 TTTPSGEALALQVTHQN-DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPF 284 TT L++T Q+ + R NKE+ V L+K +VLE + K S + Sbjct: 221 TTN------QLKLTWQDANGNSRSFNKEKIDGIVKGLDKHNATVLEIDKKQKKSFSPGLY 274 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYISDNF 343 + LQ+ A+ + G+ K+T+ + Q+LYE + TY RTDS +S D V + + Sbjct: 275 DLTELQRDANKKFGYSAKETLNIMQKLYEQHKVLTYPRTDSRYISSDIVGTLPERLKACG 334 Query: 344 GKKY---------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 +Y P N+ ++ H AI P++ V + +K+Y L+ Sbjct: 335 VGEYRPLAHKVLQKPIKANKSFVDDSKVSDHHAIIPTEGYV---NFSAFTDKERKIYDLV 391 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE------DR 448 ++F+A +Y+ TL G+ ARG+ + GW +V + D+ ++ Sbjct: 392 VKRFLAVLFPAFEYEQLTLRTKVGNETFIARGKTILHAGWKEVYENRFEDDDVTDDVKEQ 451 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK-------------------R 489 +LP + KGD LT+ + TK PARF+EA+L+ +E Sbjct: 452 LLPRIEKGDTLTVKLIMQTSGQTKAPARFNEATLLSAMENPTKYMDTQNKQLADTLKSTG 511 Query: 490 GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENS 549 G+G +T A II + + + + + G + D + E EL + T + E Sbjct: 512 GLGTVATRADIIDKLFNSFLIEKRGKDIHITSKGRQLLDLVPE---ELKSPTLTGEWEQK 568 Query: 550 LDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIR 609 L+ +A + + + + + + + + + + +++ CP CG+ M Sbjct: 569 LEAIAKGKLKKEVFISEMKNYTKEIVSEI----KSSDKKYKHDNISTKSCPDCGKPMLEV 624 Query: 610 TASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAM 669 G L C C N+ RCP+C + Sbjct: 625 NGKKGKMLVC------QDRECGHRKNVSRT------------------TNARCPQCKKKL 660 Query: 670 DSYLIDPKRKLHVCGNN 686 + + Sbjct: 661 ELRGEGAGQIFACKCGY 677 Score = 56.3 bits (134), Expect = 5e-06, Method: Composition-based stats. Identities = 25/132 (18%), Positives = 39/132 (29%), Gaps = 19/132 (14%) Query: 698 EFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVP 757 + + K + C CG M G+ GK + C + EC + +++ Sbjct: 601 DKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGH-------------RKNVSR 647 Query: 758 LPELPCEKSDAYFVLRDGAAGVFLAANTFPKS--RETRAPLVEELYRFRDRLPEKLRYLA 815 C + LR AG A K RE + E + +K Sbjct: 648 TTNARCPQCKKKLELRGEGAGQIFAC----KCGYREKLSTFQERRKKESGNKADKRDVQK 703 Query: 816 DAPQQDPEGNKT 827 QQ E Sbjct: 704 YMKQQKKEEEPL 715 >UniRef50_Q9U286 DNA topoisomerase n=3 Tax=Bilateria RepID=Q9U286_CAEEL Length = 855 Score = 532 bits (1371), Expect = e-149, Method: Composition-based stats. Identities = 167/863 (19%), Positives = 299/863 (34%), Gaps = 74/863 (8%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSV-GHIRDLPTSG--SAAKKSADSTSTKTAKK 58 L++ E P A +I L + K + + + + ++ Sbjct: 3 PTVLMVAEKPLLADSIANLLSNGQAKKRKGWNGVCSVSEYDGQFNGRAARFKVTSTCGHV 62 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEVLPG--KEKVVSELKQLAEKADHIYLATDLDREG 116 D N VDP + A + + K K+ L A+ AD + L D D+EG Sbjct: 63 MSLDFPPKFNNWERVDPAELYSAPTQRIEANPKMKMNEFLASEAKNADFLVLWLDCDKEG 122 Query: 117 EAIAWHLREVIGGDDAR--------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQAR 168 E I + + + + + R F+ IT+ I+ A G + + ++ AR Sbjct: 123 ENICFEVIDAVKCAMFKNRQDFMSDVYRAHFSAITEKDIKAAMRNLGRPDQNMSHSVDAR 182 Query: 169 RFMDRVVGYMVSPLLWKKIAR--------GLSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 + +D +G + K +S G Q+ + V R +I F PE++W Sbjct: 183 QELDLRIGCSFTRFQTKFFQGKYGDLDSNVISYGPCQTPTLGFCVTRHDQIVQFKPEQYW 242 Query: 221 EVDASTTT-PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTS 278 + + TT G+ + + R + E + V ++K VL+ K Sbjct: 243 VLKTNFTTSDDGQIFSPEWQ-----RGRIFDAEVARVFVDRIKKCHTGLVLDVSKKEARK 297 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLS--QDAVNMVR 336 + T L + AS+ LG TM +A+ LY GYI+Y RT++T S D ++ Sbjct: 298 ERPCALNTVELMRVASSSLGMSPSTTMHVAEALYTQGYISYPRTETTAYSANFDLTGTLK 357 Query: 337 GYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWR 396 D + + + H I P + + D ++Y+ + + Sbjct: 358 ILAGDRKWGSVVLADGIKRPKSGVDKGDHPPITPMR-----PNHGGLSGDMSRIYEYVSQ 412 Query: 397 QFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNK- 455 FVA M Y+ TT+ + GD + +G+ + G+T VMP L +E + ++ + Sbjct: 413 HFVATLMKQCVYEVTTVKMSCGDEQFTLQGKNVVEPGFTAVMPWLSVEEECSVPKSLQQI 472 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-N 514 G + L T PP +EA L+ +EK GIG ++ I+TI R YV VE Sbjct: 473 GAKIELQNAEIQARETTPPGYLTEAELITLMEKHGIGTDASIPVHINTITQRNYVTVESG 532 Query: 515 RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQ 574 RR ++G+ + + EL+ A++E L+ VA+ +A++ +F F Sbjct: 533 RRLVPTRLGQCLVRGYWKVDPELVLPTMRAELEEQLNLVASGKADYLD--RNFEKKF--L 588 Query: 575 LDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG--CSGY---ALPPKER 629 ++ + C C R M + C Sbjct: 589 IENFIFFKTFFVEKNENTGKPFSRCGKCRRYMKLVQTKPQRLYCPTCQETYAVPNFKDGV 648 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 K + + +V+ + R CP C + C +P+C Sbjct: 649 LKVIGDHKCPLDDFDVILYQGPGGKLARTFTLCPFCFNNPPFEKMPQGAGCDTC-VHPSC 707 Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVA 749 G + CG M L T +C + + Sbjct: 708 QYSISSNGVCGC---------LQDCGGVMLLDTQSH-PKWRMTCNKCPSVVGLFEGAIKV 757 Query: 750 PPKEDPVPLPELPCEKSDAYFVL-----RDGAAGVF-LAANTFPKSRETRAPLVEELYRF 803 CE+ DA F+ G G ++++ + + ++ Sbjct: 758 KVDSTR------SCEQCDAQFIKAEFKPNSGKPGAIEYESSSYEGC-----IFCDAMKKY 806 Query: 804 RDRLPEKLRYLADAPQQDPEGNK 826 D + YL + +Q Sbjct: 807 PDAINLNHAYLTEESRQRNTQAP 829 >UniRef50_Q3BT95 DNA topoisomerase n=14 Tax=Gammaproteobacteria RepID=Q3BT95_XANC5 Length = 670 Score = 532 bits (1371), Expect = e-149, Method: Composition-based stats. Identities = 156/686 (22%), Positives = 263/686 (38%), Gaps = 90/686 (13%) Query: 5 LVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 L + E P++ K I + LG S V +GH+ + + ++ + Sbjct: 3 LFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAAPEAYDEQLKRWSIE 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 + P+ EV P +K L KA + +ATD D Sbjct: 63 QLPIIPQ-------------------RWQVEVKPKTATQFKVVKALLAKATQLVIATDAD 103 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRFM 171 REGE IA + ++ G R+ + + +IR A K + + AR Sbjct: 104 REGELIAREIIDLCG-YRGPIERLWLSALNDASIRAALGKLRPSAETLPMYYSALARSRA 162 Query: 172 DRVVGYMVSPLLWKKIAR-----GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D +VG +S L + LS GRVQ+ ++LVV+R+REI AFV +W +D Sbjct: 163 DWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIDVYL 222 Query: 227 TTPSGEALALQVTHQN--DKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTSKPGAP 283 TT A ++ D R + + Q A + V+ E + P P Sbjct: 223 TTSGQAFTAQWISPDTCTDDSGRCLQQPVAQQAAQQIRATGSAQVVSVETERVREGPPLP 282 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDN 342 F TLQ+ S +LG V++T+ +AQ LYE TY R+DS L + V + Sbjct: 283 FDLGTLQELCSKQLGLDVQETLDIAQALYETHKATTYPRSDSGYLPESMFAEVPIVLDSL 342 Query: 343 FGKKY--------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 + L + A + AH I P+ + +L M +Y+LI Sbjct: 343 LKTDFSLRPIIDQLDRTQRSRAWNDAKVSAHHGIIPT---LEPANLSAMSEKELAVYKLI 399 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED------R 448 ++A + ++D T + G L A G+ + GW V+ + ++ + Sbjct: 400 RAHYLAQFLPHHEFDRTVANLSCGQQTLTATGKQVVVKGWRLVLAEPQPEEDSDTAARSQ 459 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE-----------------KRGI 491 +LPA+ +G + + ++ T+P +++ LVK ++ GI Sbjct: 460 VLPALREGVSCQVADVDLKALKTQPSRPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGI 519 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G +T A+IIS + RGY+ + R A + D + + + TA E +LD Sbjct: 520 GTEATRANIISGLIARGYLMKKGRAIRASDAAFTLIDAVPAA---IADPGTTAVWEQALD 576 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 + + + + +Q + + + V CP CG R+ Sbjct: 577 MIEAGQLTLDVFIGKQAAWISQLITQ------YASASLSIKVPHGPACPQCGAPTHQRSG 630 Query: 612 STGVFLGCSGYALPPKERCKTTINLV 637 +G F CS Y CK T+ + Sbjct: 631 KSGPFWSCSRYP-----DCKGTLPVE 651 Score = 56.3 bits (134), Expect = 5e-06, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 14/36 (38%) Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 C + A R G +G F + + +P + T Sbjct: 614 HGPACPQCGAPTHQRSGKSGPFWSCSRYPDCKGTLP 649 >UniRef50_B2RH95 DNA topoisomerase III n=3 Tax=Bacteroidales RepID=B2RH95_PORG3 Length = 710 Score = 532 bits (1370), Expect = e-149, Method: Composition-based stats. Identities = 137/692 (19%), Positives = 243/692 (35%), Gaps = 101/692 (14%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 + I E P+ + I LG + Y V + GH+ L A + + Sbjct: 37 IVCIAEKPSVGREIAAVLGATKAYKGYMEGNGYQVTWTFGHLCALKEPHDYAPEWKRWSI 96 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P + + + +++L +AD + D Sbjct: 97 SSLPMIPLR-----------------FGIKLIDSDSIREQFGTIEKLVHEADMVVNCGDA 139 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 +EGE I + + G R+ + +T+ +IR+ F + + A AR Sbjct: 140 GQEGELIQRWVLQKTGC-TCPVRRLWISSLTEESIREGFARLRDSEEFHSLYEAGLARAI 198 Query: 171 MDRVVGYMVSPLLWKKIA---RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D ++G + L + + LS GRVQ+ + L+V R+ EI+ F PE +WEV Sbjct: 199 GDWLLGMNATRLYTLRFGSNRQVLSIGRVQTPTLALIVRRQHEIEHFTPEVYWEVKTIYR 258 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 T N R + E + V ++ + ++V K P F + Sbjct: 259 D----------TVFNATKGRFSSIEDARREVEVVAGSPFAVTSVATKKGRELPPRLFDLT 308 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKY 347 LQ + R T+ Q LYE +Y R D+T LS D V + Sbjct: 309 GLQVECNKRFAMTADATLRTIQSLYEKKITSYPRVDTTYLSDDVFEKVPNILQGLSDYTL 368 Query: 348 LPESPNQYA-------SKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 L + H AI P+ M D ++++ L+ R+F+A Sbjct: 369 LTAPLRSSKLKKSKKVFDNSKITDHHAIIPTGQPSH-----GMSEDERRVFDLVARRFIA 423 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------PALRKGDEDRILPAVN 454 + TT+ A K G+ + GW V DE++ LP + Sbjct: 424 VFYPDCIFSQTTVLGQAAKVEFKTTGKQILEPGWRTVFTDPQTDDDGENKDEEKKLPIFS 483 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRGIGRPSTYA 498 +G++ + + T+PP ++EA+L++ +E + GIGRPST A Sbjct: 484 EGESG-VHTPEVQEKTTQPPKFYTEATLLRAMETAGKSVKDEELRDALKENGIGRPSTRA 542 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 +II T+ R Y+ E + A G + ++ + L + + T Q E L ++ + Sbjct: 543 AIIETLFKRNYIYKEKKNLKATPTGMSLIATID--YELLKSAELTGQWEYKLRRIERGDY 600 Query: 559 EWKAVLDHFFSDFTQQLDKAEK-----------------DPEEGGMRPNQMVLTSIDCPT 601 ++ T + K ++ + CP Sbjct: 601 SAADFINELKVLLTHLIPNVLKSNSSVLLSEPIPAASPAPGKKKKADKPMQKQLDLTCPV 660 Query: 602 CGRKMGIRTASTGVFLGCSGYALPPKERCKTT 633 CG+ + +R GC+ + R + Sbjct: 661 CGKGIIVRGREA---FGCNAFREGCTFRLPYS 689 >UniRef50_UPI0001C314B9 DNA topoisomerase III n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C314B9 Length = 754 Score = 530 bits (1365), Expect = e-149, Method: Composition-based stats. Identities = 150/740 (20%), Positives = 270/740 (36%), Gaps = 103/740 (13%) Query: 1 MGKALVIVESPAKAKTINKYL------------GSDYVVKSSVGHIRDLPTSGSAAKKSA 48 M K LVI E P+ + +++ L G D+++ +VGH+ L K Sbjct: 1 MPKTLVIAEKPSVGRDLSRVLAGPFRRGEGFLEGPDHILTWAVGHLVQLAEPDEYDDKFK 60 Query: 49 DSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HI 106 P+K ++ ++ +K+ + D + Sbjct: 61 RWRMADLPIVPEKFRL------------------VVRDERSKRQMNVVKRQLGRDDIGVV 102 Query: 107 YLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNA 164 A D REGE I +L E G R+ + +T+ AIR AF + + +A Sbjct: 103 VNACDAGREGELIFAYLYEKAG-SRLPVQRLWLSSMTQTAIRNAFGQLRDGAEMKSLEDA 161 Query: 165 QQARRFMDRVVGYMVSPLLWKKIA----RGLSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 ++R D +VG + ++ +S GRVQ+ + ++ RE EI+AF PE +W Sbjct: 162 ARSRSEADWIVGMNSTRAATIRLRSSFDGAVSLGRVQTPTLAILARREEEIRAFRPEPYW 221 Query: 221 EVDASTTTPSGEALALQVT----HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPT 276 VDA+ + + + R + E A V + + E + Sbjct: 222 TVDATFAASGERVYDGRFHVTAGSGDGRGPRIGSAEFAAAVVEACRGTDGVITKLEKRKR 281 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMV 335 + + ++LQ+ A++R GF ++T+ AQRLYE +TY RT S L D + + Sbjct: 282 RERVPLLYDLTSLQRDANSRFGFSARRTLAAAQRLYEEHKALTYPRTASRYLPTDMIPEI 341 Query: 336 RGYIS-------DNFGKKY---LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEA 385 + G +Y L P + H AI P+ + M Sbjct: 342 KPIAEIVGGRSEYAAGARYVLGLDVLPLARVVNDARVTDHHAIIPTRA---PHPVDRMGD 398 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD 445 D +++Y L+ ++F+A A++++T++ + RG+++ GW V + Sbjct: 399 DDRRIYDLVAKRFLAVFHPDAEFENTSVETEVAGHAFRTRGKVMLVPGWRGVYGESADAE 458 Query: 446 ---------EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR------- 489 ++ LP + +G+ + E+ Q T+PP R+SE SL+ +E Sbjct: 459 PREGEEDEGREQQLPKLEQGEDVQTREIRSEQKETRPPRRYSEGSLLAAMETAGKLVDEE 518 Query: 490 ---------GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNY 540 GIG P+T A+II + GY+ + R + G V L+ + L + Sbjct: 519 ELREAMKDSGIGTPATRAAIIERLLAVGYIERDGRALVVTEKGLNVIRLLDGH--PLTSP 576 Query: 541 DFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCP 600 T E+ L ++ +E +A + + + + + + CP Sbjct: 577 SLTGDWEHRLGKIELNEDSRRAFMADIVKFAESTVAELDAKLRDVRIP----RANLGPCP 632 Query: 601 TCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKR 660 CG + G C C I G+ R Sbjct: 633 VCGHDIM--ENRKG--FSC---WSRDDPGCGFVIWKSKA--------GKTLSGAIARELI 677 Query: 661 RCPKCGTAMDSYLIDPKRKL 680 R + + + R Sbjct: 678 RTGRTEKPVTGFRSRAGRSF 697 >UniRef50_D0LL88 DNA topoisomerase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LL88_HALO1 Length = 867 Score = 530 bits (1364), Expect = e-148, Method: Composition-based stats. Identities = 148/679 (21%), Positives = 241/679 (35%), Gaps = 105/679 (15%) Query: 2 GKALVIVESPAKAKTINK----------YL-GSDYVVKSSVGHIRDLPTSGSAAKKSADS 50 L+I E P+ A+ I + YL G Y V +GH+ +L K Sbjct: 3 ATTLIIAEKPSMARDIARVVGARSKREGYLEGGGYWVSWCIGHLAELCEPHEYDAKWKSW 62 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQL--AEKADHIYL 108 + + P E + L +L A + I Sbjct: 63 SPSLLPILPD-------------------ELRVRPSRSGAAHLRVLHRLMRAREVGTIVN 103 Query: 109 ATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQ 166 A D REGE I H+ + R+ + +T AIR+ + D +A + Sbjct: 104 ACDAGREGELIFRHV-HALSNTRKPVRRLWISSLTGEAIRRGMSALRPGAEFDDLADAAR 162 Query: 167 ARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 AR D +VG + L + G +S GRVQ+ + L+V REREI++F + FW Sbjct: 163 ARADADWLVGMNATRALTGLVRSGGTRGLLMSVGRVQTPTLALIVRREREIESFESKPFW 222 Query: 221 EVDASTTTPSGEALALQVTHQNDKPF--------------------------------RP 248 +V A+ P + + Q + R Sbjct: 223 QVLATFAVPGEAGASYEGIWQRPREAGDDAGDAQRDNKGDAQRDNKGDGDTNTARDRSRV 282 Query: 249 VNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMA 308 ++Q A + ++ + K T +P F + LQ+ A+ R K+T+ +A Sbjct: 283 PTRQQADAIADAVRGRAGTITQLTRKSTRERPPLLFDLTNLQKLANRRFRMSAKRTLELA 342 Query: 309 QRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDNFGK----------KYLPESPNQYAS 357 Q LYE ITY RTD+ L+ D + + G+ + N+ Sbjct: 343 QALYETHKLITYPRTDARYLTDDLAPTLPELVRALAGEYPGLRDTALAGAAHAAGNRRIF 402 Query: 358 KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA 417 H AI P+ + AD ++LY LI R+F+A A YD T + Sbjct: 403 DNAQVGDHHAIIPTAKAPSP---GRLSADERRLYDLIARRFLASLFPDAVYDQTKIVTTV 459 Query: 418 GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARF 477 R+ GW + P + LP + + + + + T+PP R+ Sbjct: 460 AGHCFATERRVCAEPGWQQAEPPPPAKRNEPPLPRLRQDMEVDTAAIEVREGKTQPPKRY 519 Query: 478 SEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEK 521 SEASL+ +E G+G P+T A+II T+ R Y+ + R + Sbjct: 520 SEASLLGAMEHAGRSLDDPGLRRVMRDAGLGTPATRAAIIETLLKRSYIERQGRELVPTE 579 Query: 522 MGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD 581 G + + +L++ + TA E LD +A A +D + +D + Sbjct: 580 QGRALIASVP--IEDLLSAELTADWEQKLDAIARGRASKARFMDEIHGYVRRIVDALAQA 637 Query: 582 PEEGGMRPNQMVLTSIDCP 600 P VL Sbjct: 638 TPPSLPSPTDEVLGLCPVC 656 >UniRef50_C3QFV7 DNA topoisomerase III n=28 Tax=Bacteroidales RepID=C3QFV7_9BACE Length = 725 Score = 529 bits (1363), Expect = e-148, Method: Composition-based stats. Identities = 149/754 (19%), Positives = 264/754 (35%), Gaps = 92/754 (12%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 + I E P+ A+ I + LG + Y V + GH+ L + Sbjct: 2 IVCIAEKPSVARDIAEVLGAHTRKEGYIEGNGYQVTWTFGHLCTLKEPHEYTPNWKSWSL 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P + + + PG EK ++ L + AD I D Sbjct: 62 SSLPMIPPRFGIKLIGH----------------DPGIEKQFHVIEWLMQNADEIINCGDA 105 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 +EGE I + + G R+ + +T+ AIR+ F+K + A +R Sbjct: 106 GQEGELIQRWVMQKAGAR-CPVKRLWISSLTEEAIREGFSKLKDQAEFQSLYEAGLSRAM 164 Query: 171 MDRVVGYMVSPLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D ++G + L K + LS GRVQ+ + L+V R+ EI F P+++WE+ + Sbjct: 165 GDWLLGMNATRLYTLKYGQNKQVLSIGRVQTPTLALIVNRQLEIANFEPKQYWELKTNYR 224 Query: 228 T--------PSGEALALQVTHQNDKPFR-------PVNKEQTQAAVSLLEKARYSVLERE 272 S E +A + K N+E+ +A V ++ + V Sbjct: 225 NTTFSALIRKSDEEIAAEEEKNGGKKKIDNPGIDPIANREEGEALVERIKDLPFVVTNVG 284 Query: 273 DKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV 332 K F ++LQ + + + +T+ + Q LYE TY R D+T LS D Sbjct: 285 KKDGKEYAPRLFDLTSLQVECNKKFAYSADETLKLIQSLYEKKVATYPRVDTTFLSDDIY 344 Query: 333 NMVRGYISDNFGKKYLPES-------PNQYASKENSQEAHEAIRPSDVNVMAESLKDMEA 385 + + L ++ + H AI P+ V ++ Sbjct: 345 PKCPAILKGLRDYEVLTAPLAGTTLLKSKKVFDNSKVTDHHAIIPTGVYAQ-----NLTD 399 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG- 444 +++Y LI R+F+A K +TT+ + G+ + GW V K Sbjct: 400 MERRVYDLIARRFIAVFYPDCKISTTTVMGEVDKIEFRVTGKQILEPGWRVVFAKEVKDP 459 Query: 445 ------DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------- 487 +++ +LPA KG++ + + +T+PP ++EA+L++ +E Sbjct: 460 TEEKEEEDENVLPAFVKGESGPHI-PDLNEKWTQPPRPYTEATLLRAMETAGKLVDNDEL 518 Query: 488 -----KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDF 542 + GIGRPST A+II T+ R Y+R E + A G + + E L + + Sbjct: 519 RDALKENGIGRPSTRAAIIETLFKRNYIRKERKNLIATPTGVELVQLIHEEL--LKSAEL 576 Query: 543 TAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTC 602 T E L ++ + + L+ ++ + D + V + Sbjct: 577 TGIWEKKLREIEKKTYDARQFLEELKQMVSEIVMSVLSDNTNRRITIQDAVAAKAEEKEK 636 Query: 603 GRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRC 662 + A KT P + A + C Sbjct: 637 KEPKKRERKPSTPKEK-KPKAEKTTNEVKTDSPGSPAPVAMAASTPSTAGEVDAFVGQPC 695 Query: 663 PKCGTAMDSYLIDPKRKLHVCGNNPT-CDGYEIE 695 P CG + + C C + Sbjct: 696 PLCGKGTII----KGKTAYGCSEWRNGCTFRKNF 725 >UniRef50_C5B550 DNA topoisomerase n=1 Tax=Methylobacterium extorquens AM1 RepID=C5B550_METEA Length = 888 Score = 529 bits (1362), Expect = e-148, Method: Composition-based stats. Identities = 175/888 (19%), Positives = 295/888 (33%), Gaps = 130/888 (14%) Query: 1 MGKALVIVESPAKAKTINKYL----------GSDYV------VKSSVGHIRDLPTSGSAA 44 M + L I E PA + I L G ++ V ++GH D G + Sbjct: 1 MPQRLFIAEKPALGRAIATALATLSGARPSAGRGFIEVGGDCVTWTIGHAYDTAEPGDYS 60 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD 104 + + V P ++ LK + D Sbjct: 61 STWDKWS-------------------LDVLPMLPERWKLVPNAEIADQIAVLKDRIRRYD 101 Query: 105 HIYLATDLDREGEAIAWHLREVIGGDD--ARYSRVVFNEITKNAIRQAFNK--PGELNID 160 H D +REG+ I + G D + SRV + + + A P Sbjct: 102 HFVNVGDAEREGQLIVDEILIENGVDPFSPKVSRVWVSSFVEKDVAAAVAGAFPNSQKKS 161 Query: 161 RVNAQQARRFMDRVVGYMVSPLLWKKIAR------GLSAGRVQSVAVRLVVEREREIKAF 214 A AR+ D ++G +S + + + +S GRVQ+ ++LVV+R+ +I+ F Sbjct: 162 LYEAAVARQRADWLLGMNMSRVFGLMVQQSGARGFRVSVGRVQTPTLKLVVDRDWQIENF 221 Query: 215 VPEEFWEVDASTTTPSGEALALQ----VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLE 270 + + + +G A T D R ++K QA V + +V Sbjct: 222 KAVDHFAPSITFVHENGTFKAAWQFPADTKGLDPEGRLLDKAVAQALVQKIAGKTGTVES 281 Query: 271 REDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQ 329 + P ++ P PF STLQ+A S + G ++T+ +AQ LYE ITY R+DS +L Sbjct: 282 YSETPKSTSPPLPFALSTLQKACSQKFGLTAQQTLDVAQELYEKHKAITYPRSDSQHLPN 341 Query: 330 DAV-NMVRGYISDNFGKKYL-------PESPNQYASKENSQEAHEAIRPSDVNVMAESLK 381 + G + + G + L A + H I P+ A L Sbjct: 342 SVHTDEADGILRNLAGVRELADAAGRANPKLKSPAFDDKKVTDHHGIIPTS-EASASKLA 400 Query: 382 DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPAL 441 M +K++ LI R FVA +Y S+ TV R KA G + GW V A Sbjct: 401 AMGEIERKVFLLIARTFVAQFHPDFRYVSSAATVLCEGERFKATGTRVVDQGWKTVFGAE 460 Query: 442 RKGDEDR---ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------ 486 +E+ LP++ D + + TKPPA F + +LV+ + Sbjct: 461 EADEEEEAEGTLPSMKMKDPVDAKAGSIDPKRTKPPAHFDDGTLVEAMAKIHLYVQDQEV 520 Query: 487 -----EKRGIGRPSTYASIISTIQDRGYVRV----ENRRFYAEKMGEIVTDRLEENFREL 537 E GIG +T AS+I + Y+ + + + G + D L +L Sbjct: 521 RKRLRENDGIGTEATRASMIEKLIRAKYLERRTKGKRKILVSTDAGRQLVDLLP---SDL 577 Query: 538 MNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK--DPEEGGMRPNQMVLT 595 + D TA E+ L++V E +D +++ A + G + Sbjct: 578 VAPDTTAMWESFLERVKGGEFTLAQFMDRQTQFVRKRVQTAIAAGAIQVKGFSVEPLEGH 637 Query: 596 SIDCPTCGRKMGI-------RTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 +CP C + FL C + + C+ EG Sbjct: 638 GTECPHCRAGHLVTQLWPFDDEYKGRRFLRCDNWVKDRADNCRYKTP----------PEG 687 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPI 708 CP CG + + K + C + E+ + Sbjct: 688 YKEREKLEGEGNPCPACGKGVLKGGVVRKEGPNRGRPFLMCSEVDREKPDSCQHFEWKDE 747 Query: 709 VECEKCGSEMHLK-------MGRFGKYMACT------NEECKNTRKILRNGEVAPPKEDP 755 C CG + + + + C+ + C++ + P Sbjct: 748 TPCPSCGKGVLKRGVVRKEGPNKGRPFAMCSAVDRTNPDGCQHFSWLDEKAAKGPK---- 803 Query: 756 VPLPELPCEKSD-AYFVLRDGAA--GVFLAANTFPK-----SRETRAP 795 + C + R G FL+ + + + P Sbjct: 804 IKGEGELCTVCGKGTMMRRTGRTSGKPFLSCSNWKQGASDSCDNRVFP 851 >UniRef50_B7AD12 Putative uncharacterized protein n=4 Tax=Bacteroides RepID=B7AD12_9BACE Length = 729 Score = 528 bits (1361), Expect = e-148, Method: Composition-based stats. Identities = 143/763 (18%), Positives = 257/763 (33%), Gaps = 106/763 (13%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 + I E P+ A+ I LG + Y V + GH+ L + Sbjct: 2 IVCIAEKPSVARDIADVLGARDKRDGYIEGNGYQVTWTFGHLCTLKEPHEYTPNWKSWSL 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 P + + P E+ ++ L + AD I D Sbjct: 62 GSLPMVPPR-----------------FGIKLISNPTYERQFHVIENLMQHADMIINCGDA 104 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 +EGE I + + G R+ + +T+ AIR+ F K + A +R Sbjct: 105 GQEGELIQRWVMQKAGAR-CPVKRLWISSLTEEAIREGFAKLRDASDFQPLYEAGLSRAI 163 Query: 171 MDRVVGYMVSPLLWKKIARG---LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D ++G + L K + LS GRVQ+ + L+V R+ EI+ FVP+++WE+ Sbjct: 164 GDWLLGMNATRLYTMKYGQNRQVLSIGRVQTPTLALIVNRQLEIQNFVPKQYWELKTVYR 223 Query: 228 T---------------------PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARY 266 G A +N ++E+ A + + A + Sbjct: 224 DTTFSAILRKSDEELVLEAEKQKEGAAAKAAKPEENRGIEPITDRERGTALLEQIRNAPF 283 Query: 267 SVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTN 326 ++ K P F ++LQ + + F +T+ Q LYE TY R D+T Sbjct: 284 TITNVTRKNGKEAPLRLFDLTSLQVECNKKFAFSADETLKTIQSLYEKKVTTYPRVDTTF 343 Query: 327 LSQDAVNMVRGYISDNFGKKYLPES-------PNQYASKENSQEAHEAIRPSDVNVMAES 379 LS D G + + L ++ + H AI P+ Sbjct: 344 LSDDIYPKCPGILKGLRDYQALTAPLEGTTLLKSKKVFDNSKVTDHHAIIPTGQPPQ--- 400 Query: 380 LKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP 439 ++ ++++ LI R+F+A + +TT+ K G+ + GW V Sbjct: 401 --NLTDMERRVFDLIARRFIAVFYPDCLFATTTVIGEVEQIEFKVSGKQILEPGWRVVFG 458 Query: 440 ALRKGDE----------DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE-- 487 + + +LPA G++ + + +T+PP ++EA+L++ +E Sbjct: 459 TPSAQSQEEKDEKGGEEENVLPAFVVGESGPHL-PDLYEKWTQPPRPYTEATLLRAMETA 517 Query: 488 --------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEEN 533 + GIGRPST A+II T+ R Y+R E + A G + + E Sbjct: 518 GKLVDNDELRDALKENGIGRPSTRAAIIETLFKRNYIRKEKKNLIATPTGVELIQIIHEE 577 Query: 534 FRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMV 593 L + + T E L ++ L+ ++ + D + Sbjct: 578 L--LKSAELTGIWEKKLREIEKRTYNAGQFLEELKQMVSEIVMSVLSDNSNRHITIQAPA 635 Query: 594 LTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAET 653 G+ +++ P K K T ++ + Sbjct: 636 PEKG-----GKNSASSASASDKPKKEPKKRAPRKSAAKKTETATTDSLPAAAEQPASVVQ 690 Query: 654 NALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPT-CDGYEIE 695 + CP CG + + C + C + Sbjct: 691 ADELVGQPCPLCGKGTVI----KGKTAYGCSEWKSGCTFRKPF 729 >UniRef50_Q67NT6 DNA topoisomerase n=1 Tax=Symbiobacterium thermophilum RepID=Q67NT6_SYMTH Length = 783 Score = 528 bits (1360), Expect = e-148, Method: Composition-based stats. Identities = 155/656 (23%), Positives = 265/656 (40%), Gaps = 79/656 (12%) Query: 2 GKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADS 50 GK L+I E P+ A I + LG +Y++ ++GH+ +L + + Sbjct: 3 GKPLIIAEKPSAAMAIAQALGGFQRRDGYLESAEYLLSWAIGHLVELLPPEAYDPRWKRW 62 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLAT 110 T P+ VLP L +L ++A + A Sbjct: 63 TMETLPILPEG-------------------FGLHVLPKTRSQFRTLARLGKQAPLLVNAC 103 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQAR 168 D REGE I ++ G + R+ + +T AIR AF KP E + + R Sbjct: 104 DAGREGELIFRYICAAAGLE-KPVMRLWVSALTPAAIRAAFAEMKPQEHYDRLYRSARCR 162 Query: 169 RFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D +VG + K LSAGRVQ+ + +VV REREI++F PE +WEV A+ T Sbjct: 163 AEGDWLVGINATRAFTVKFGELLSAGRVQTPTLAMVVRREREIESFRPEPYWEVFAAFRT 222 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 P G + + R + + +A V + + V +++P +P F ++ Sbjct: 223 PDGREYTGKWFGPDGD--RLSSADAAEAVVRRVRRQAGWVEASDERPVAERPPQLFDLTS 280 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LQ+ A+ R G T+ AQ LYEA +ITY RTDS LS+ V + + + L Sbjct: 281 LQREANRRYGLTAAATLKAAQALYEAKHITYPRTDSRYLSRALVPQLPALVRALSARSDL 340 Query: 349 PESP-----------NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 N+ + H AI P+ E + + K+Y LI R+ Sbjct: 341 AALAAGADLSRVGFGNRRVVDDAKVTDHHAILPTS-----EVPRSLTGAEAKIYDLIVRR 395 Query: 398 FVACQMTPAKYDSTTLTVGAGDF--RLKARGRILRFDGWTKVMPALRKGDED-------- 447 F+A A++ + G+ R ++RGR L GW +V P + Sbjct: 396 FLAQFYPDARFLEQEVVTCVGELPDRFRSRGRRLVDPGWRQVEPEPARKRRAAEDEEEEG 455 Query: 448 -RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRG 490 ++LP + G+ + + ++ + T+PP R++EA+L+ +E G Sbjct: 456 LQLLPPLRMGEPVAVGDVESREKATRPPRRYTEATLLSAMEYAGREITDEALREAMKGHG 515 Query: 491 IGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE-LMNYDFTAQMENS 549 +G P+T A+II +++ GY+ E R G + + E E L++ + T + E+ Sbjct: 516 LGTPATRAAIIERLKEMGYIITERRSLVPTAKGRRLVELAERAGVEVLLSPELTGEWEHR 575 Query: 550 LDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRK 605 + + + E + + + +++ G T+ P Sbjct: 576 IAGIQSGEYDDARFMQEIRELTARLVERIRATEGAPGRGGAGRSSTAEPGPAKEEP 631 >UniRef50_Q8T2T7 DNA topoisomerase 3 n=1 Tax=Dictyostelium discoideum RepID=TOP3_DICDI Length = 828 Score = 528 bits (1359), Expect = e-148, Method: Composition-based stats. Identities = 154/767 (20%), Positives = 273/767 (35%), Gaps = 70/767 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVK----SSVGHIRDLPTSGSAAKKSADSTSTKTAK 57 + L + E P+ AK I L + S + D + + ++ T Sbjct: 3 KRILNVAEKPSAAKEIAAILSNKRATVREGFSKYNKLWDFKYNILNFNDCEMTFTSVTGH 62 Query: 58 KPKKDERGALVNRMGVDPWHNWEAHYE--VLPGKEKVVSELKQLAEKADHIYLATDLDRE 115 + D DP ++A V KE + L++ +KAD + L D DRE Sbjct: 63 LMEIDVVEQFKPWASCDPIQLFDAPIRKTVPSDKEPLKKTLEREIKKADILILWLDCDRE 122 Query: 116 GEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 GE IA+ + EV + + R F+ I I +A + N A R +D Sbjct: 123 GENIAFEVLEVCKNAKKKFEFYRAHFSAIIPREIDRACKNLAKPNEKDSIAVDTRMEIDL 182 Query: 174 VVGYMVSPLLWKKIAR---------------------------------GLSAGRVQSVA 200 +G + + + +S G Q Sbjct: 183 RIGAAFTRFQTLYLKKFKIISNSDNQPKTTTPANGNILNNSNNNSSGKEIISYGPCQFPT 242 Query: 201 VRLVVEREREIKAFVPEEFWEVDA---STTTPSGEALALQVTHQNDKPFRPVNKEQTQAA 257 + VVER I F PE+FW + T SG+ + + + ++ F Sbjct: 243 LGFVVERYFRIVNFKPEDFWHLSVVHEKMDTSSGKMIPVTFSWCRNRLFDYT--AAFILY 300 Query: 258 VSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI 317 L+ +V++ K + P T LQ+AAS +L +TM A+ LY G I Sbjct: 301 EKCLDNTEATVVDVTSKE-SRYRPVPLTTIELQKAASKKLRISSVQTMQYAEELYTKGLI 359 Query: 318 TYMRTDSTNL--SQDAVNMVRGYISDNFGKKYLPESPN-----QYASKENSQEAHEAIRP 370 +Y RT++ + D ++ S+ Y N S +N+ +H I P Sbjct: 360 SYPRTETDSFQAGTDLKGLIGNQASNPEWGAYASRLINNNQFVYPKSGKNNDNSHPPIHP 419 Query: 371 SDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILR 430 + S + + +K+Y I R+F+AC + + +TT+T+ R G ++ Sbjct: 420 TS------SATGLSGNLKKIYDFITRRFLACCSEESVFANTTVTIDIQGERFSETGTMVL 473 Query: 431 FDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRG 490 G+ +V P ++ D +++P KG+ T + + T P +EA L+ ++ Sbjct: 474 KLGYLEVYPFDKRND--KLIPTYQKGERFTPKRIDLTKGTTVAPHYITEAELLTAMDNNK 531 Query: 491 IGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENS 549 IG +T A+ I TIQDR YV+ E+ +F +G + E E + A +E Sbjct: 532 IGTDATMATHIQTIQDRFYVKKNESNQFVPSNLGVSLVASYELMGFEFSKPNLRAAIEAD 591 Query: 550 LDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIR 609 +D+++ + + VL + Q A ++ + + R + + Sbjct: 592 VDKISRGQKTKQEVLLSTIEKYKQLYQLANQNINCFDRSFREYYEPADPKGGEFRVLVSQ 651 Query: 610 TASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETN---ALRAKRRCPKCG 666 + G G Y I P+ L + ++ + CP C Sbjct: 652 FSRCGKCNGKMQYKSDQNPEAPKRILFCPQCIDTFDLPKNGDISQLVTSMGVPQNCPICQ 711 Query: 667 TAMDSYLID-PKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 + S + +C P C + + C Sbjct: 712 YQVLSVRNPINDKSYTIC---PKCRNSPPDPIHKKPFHCFQCTFNCN 755 >UniRef50_Q21RE9 DNA topoisomerase III n=34 Tax=Bacteria RepID=Q21RE9_RHOFD Length = 1017 Score = 528 bits (1359), Expect = e-148, Method: Composition-based stats. Identities = 185/877 (21%), Positives = 310/877 (35%), Gaps = 138/877 (15%) Query: 3 KALVIVESPAKAKTINKYL---------------GSDYVVKSSVGHIRDLPTSGSAAKKS 47 K L+I E P+ A+ I + L YVV S+VGH+ ++ K Sbjct: 17 KTLIIAEKPSVAQDIVRALTPVAGKFDKHDEHFESDSYVVTSAVGHLLEIQAPEEFDVKR 76 Query: 48 ADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK--ADH 105 + P + + + ++ + +LA++ D Sbjct: 77 GKWSFAHLPVIPPH-------------------FDLKPVDKTKTRLNAVVKLAKRKDVDQ 117 Query: 106 IYLATDLDREGEAIAWHLREVIGGDD---ARYSRVVFNEITKNAIRQAFNKPGELNI--D 160 + A D REGE I + + GG R+ +T AIR FN Sbjct: 118 LINACDAGREGELIFRLIEQYAGGAKPLGKPVRRLWLQSMTPQAIRDGFNTLRSNEQMLP 177 Query: 161 RVNAQQARRFMDRVVGYMVSPLLWKKIAR-----GLSAGRVQSVAVRLVVEREREIKAFV 215 +A + R D +VG + + +R + GRVQ+ + +VVERE +I+AFV Sbjct: 178 LADAARCRSEADWLVGINGTRAMTAFNSRDGGFFLTTVGRVQTPTLSVVVEREEKIRAFV 237 Query: 216 PEEFWEVDASTTTPSGEALALQVTHQNDKPF------------------RPVNKEQTQAA 257 ++WEV A+ +G+ A Q K R + + QA Sbjct: 238 SRDYWEVHATFAAQAGDYPAKWFDPQWKKAAANAAAGNLEEADPELKADRLWQQREAQAI 297 Query: 258 VSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY- 316 + SV E E KPTT F ++LQ+ A+ + GF K T+ +AQ LYE Sbjct: 298 ADAVRGQTASVTE-ESKPTTQASPLLFDLTSLQREANGKFGFSAKTTLSIAQSLYERHKA 356 Query: 317 ITYMRTDSTNLSQDAVNMVR---GYISDNFGKKYLPE----------SPNQYASKENSQE 363 +TY RTDS L +D + +V+ +S + + P P++ + Sbjct: 357 LTYPRTDSRALPEDYLPVVKQTFEMLSKSAMRHLAPHALTALNNNYIRPSKRIFDNSKVS 416 Query: 364 AHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLK 423 H AI P+ ++ + QK+Y L+ R+F+A A+Y TT A K Sbjct: 417 DHFAIIPT-----LQAPSGLSEAEQKIYDLVVRRFMAVFFPNAEYQITTRISVAAGHSFK 471 Query: 424 ARGRILRFDGWTKVMPAL-----------RKGDEDRILPAVNKGDALTLVELTPAQHFTK 472 G++L GW + + GD+ + L V G+ +T + T+ Sbjct: 472 TEGKVLVKPGWLAIYGKEAVDEVTDRDGAKDGDKGQRLVPVQAGERVTAQTVEARGLKTR 531 Query: 473 PPARFSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVENRR 516 PPAR++EA+L+ +E ++G+G P+T ASII + + Y+ E R Sbjct: 532 PPARYTEATLLGAMEGAGKTIEDDELRAAMHEKGLGTPATRASIIEGLLTQKYMLREGRE 591 Query: 517 FYAEKMGEIVTDRLEENF-RELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL 575 + L +EL + T + E+ L + + + + + + + Sbjct: 592 LIPTASAFQLMTLLRGLDVKELSKAELTGEWEHKLALMEHGQLSRAEFMAEIAAMTERMV 651 Query: 576 DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 +A++ P + CP CG + C+G +E C + Sbjct: 652 KQAKEYDR--DTVPGNYATLTAPCPNCGGIIKENYRRYT----CTG-KTGAEEGCGFSFG 704 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTA-----MDSYLIDPKRKLHVCGNNPTCD 690 P V E E + + D + K + + D Sbjct: 705 KTPAGRTFEVAEVEQFLRDKKIGPLEGFRSKAGWPFTAEMVIKFDEESKNYKLEFDFGDD 764 Query: 691 GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTN---------EECKNTRK 741 E GE + C KCG+ + GK C C Sbjct: 765 KKGEESGELIDFSGQESLGACPKCGAPVFE----HGKNYVCEKSVPTDAQATPSCDFKTG 820 Query: 742 ILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG 778 + + ++ L + D FV G Sbjct: 821 QIILQQPIEREQIAKLLATGKTDLLDK-FVSMRTRRG 856 >UniRef50_O58356 DNA topoisomerase 1 n=2 Tax=Pyrococcus RepID=TOP1_PYRHO Length = 686 Score = 527 bits (1358), Expect = e-148, Method: Composition-based stats. Identities = 172/716 (24%), Positives = 295/716 (41%), Gaps = 63/716 (8%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+I E P A+ I L +K S + +P + ++ Sbjct: 2 ILIIAEKPNVARKIAGALSERRPIKKS---LFGVPYYEIFREGKKLIVASAVGHLYGLAP 58 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKE---KVVSELKQLAEKADHIYLATDLDREGEAIA 120 + + D W Y GKE + + L LA++ +A D D EGE I Sbjct: 59 KRDVFGYPIFDIE--WVPVYIAEKGKEYAREYIKALSVLAKRVREFIVACDYDTEGEVIG 116 Query: 121 WHLREVIGGDDARY-SRVVFNEITKNAIRQAFNKPGE-LNIDRVNAQQARRFMDRVVGYM 178 + + G D R R+ F+ +TK + A+ +N NA AR +D G Sbjct: 117 YTALKYACGVDPRVAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHILDWYWGVN 176 Query: 179 VSPLLWKKIAR------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE 232 +S L I + LS GRVQ ++ +VEREREI++FVP +W + + Sbjct: 177 LSRALTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPRPYWVIKLIFEKNGQK 236 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQA 292 A N + + +E+ + V ++K+ V E K P PF TLQ+ Sbjct: 237 FTA------NYEKDKIWEEEEGKRIVLEVKKSIPRVSNVEIKRQKRTPPHPFDLGTLQRE 290 Query: 293 ASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD------AVNMVRGYISDNFGKK 346 A + GF KKT+ +AQ LYE G+ +Y RT+S L ++ N+ + + Sbjct: 291 AYSAFGFSPKKTLDIAQSLYEKGFSSYPRTESQKLPRNINFRMIIQNLAKMPQYRPYAHI 350 Query: 347 YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPA 406 L + + AH AI P+ D+ D +KLY +I R+F+A M PA Sbjct: 351 LLGLPELKPVEGKKEDPAHPAIYPTGEIPRP---GDLTKDEEKLYDMIVRRFLAVFMEPA 407 Query: 407 KYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTP 466 +S +T+ AG + G GW V K E+ LP G+ + ++++ Sbjct: 408 IRESVKVTIRAGPHKFFLSGGRTVKKGWLSVYGKYVKF-EEVTLPEFFIGERIKVIQVKR 466 Query: 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIV 526 + TKPPAR+S A+++K++E G+G +T A I+ T+ RGY+ + + +G V Sbjct: 467 EKKKTKPPARYSPAAVIKKMEDLGLGTKATRAQILETLYQRGYIEGK-KSIKVTPLGMKV 525 Query: 527 TDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGG 586 + LE+ E+++ + T + E ++ + + V++ T+ L++ +K E G Sbjct: 526 IETLEKYVPEIISVELTREFEKKMELIMEGRLTKEEVIEEAKERLTKILEEFKKRELEIG 585 Query: 587 M--------RPNQMVLTSIDCPTCGRKMGIRTAST--GVFLGCSGYALPPKERCKTTINL 636 + L CP CG + ++ F+GCS + +C T + Sbjct: 586 IELAKIVVGEDEVKPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWP-----KCDVTYPI 640 Query: 637 VPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGY 692 + E++ + G + + R+ +C + C + Sbjct: 641 LQRGEIIPTNKTCCN--------------GAPVVIIREEDGREFEIC-LDINCKDW 681 Score = 49.7 bits (117), Expect = 4e-04, Method: Composition-based stats. Identities = 12/106 (11%), Positives = 34/106 (32%), Gaps = 15/106 (14%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAA--GVFLAANTFPKSRETRAPLVEELY 801 ++ +++ PL C K +++ F+ + +PK T L Sbjct: 587 ELAKIVVGEDEVKPLVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPIL----- 641 Query: 802 RFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDGK 847 + + +P + G ++ ++ + + + K Sbjct: 642 QRGEIIPTN--------KTCCNGAPVVIIREEDGREFEICLDINCK 679 >UniRef50_Q9NG98 DNA topoisomerase 3-alpha n=10 Tax=Eukaryota RepID=TOP3A_DROME Length = 1250 Score = 526 bits (1354), Expect = e-147, Method: Composition-based stats. Identities = 145/731 (19%), Positives = 270/731 (36%), Gaps = 81/731 (11%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 K L + E AKTI L + S + D TS Sbjct: 27 KYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYNKVFDFEAPVRGQNAKMVMTSVS-GHM 85 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYE--VLPGKEKVVSELKQLAEKADHIYLATDLDREG 116 + + + N VDP ++A + V E + L++ + + TD DREG Sbjct: 86 MQLAFQVSYKNWRTVDPRSLFDAPVKKGVGSDYEPIKRTLEREVRGCQGLIIWTDCDREG 145 Query: 117 EAIAWHLREVIG--GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E I + + +V + R F+EIT A+R+A + G+ + + +A R +D Sbjct: 146 ENIGYEIIDVCRAIKPNISVYRATFSEITTVAVRRALQQLGQPDKRQSDAVDVRTELDLR 205 Query: 175 VGYMVSPLLWKKIA---------RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 G ++ ++ + +S G Q + V ER +EI+AFV E FW++ Sbjct: 206 TGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPTLGFVAERYKEIEAFVSEPFWKIKVL 265 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 T L ++ ++ F E R V KP P Sbjct: 266 HTIDD---LTVEFNWARNRLFDKEACENYLLLCLAEPDPRALVESVTVKPKHKWRPTPLD 322 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGYISDN- 342 T +++ S +L K+TM +A++LY G+I+Y RT++ S++ +V Sbjct: 323 TVEMEKLGSRKLKLSAKETMTIAEKLYTKGFISYPRTETNQFSKEFALAPLVEMQTGHRD 382 Query: 343 ---FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFV 399 F ++ + PN + S +AH I P+ + ++++ + ++Y+L+ R F+ Sbjct: 383 WGAFAQRVIEWGPN-PRNGNKSDQAHPPIHPTKLA------ENLQGNEARVYELVVRHFL 435 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 AC A T + + + A G ++ + V + + + G Sbjct: 436 ACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNYLDVYVYDKWSA--KQIHHYENGQRF 493 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV-RVENRRFY 518 E++ + T P +EA L+ +EK GIG +T+A I+TI++RGY+ ++ Sbjct: 494 EPTEVSLHEGATTAPPLLTEADLIALMEKHGIGTDATHAEHINTIKERGYIGVLDKGFLV 553 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 +G + + + L A+ E L + + + K VL + + Q + Sbjct: 554 PGVIGMGLYEGYDAMELALAKPQLRAEFELDLKLICQGQKDPKVVLTEQIAKYKQAYQQI 613 Query: 579 EKDPEEGGMRP------------------------NQMVLTSIDCPTCGR-KMGIRTAST 613 + + ++ + CP C + ++ Sbjct: 614 TDKITAMDAKISARINETPAANSAVQEGADGSAPSHGIIQSIFQCPKCNEAPLALKPKKN 673 Query: 614 --GVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDS 671 G ++GC+ + CK + L E + +VL+ CP CG Sbjct: 674 QQGWYIGCNNFP-----DCKNAVWLPTECKDASVLDE------------CCPTCGDGYRM 716 Query: 672 YLIDPKRKLHV 682 + Sbjct: 717 LKFRLSTPYYR 727 Score = 44.3 bits (103), Expect = 0.022, Method: Composition-based stats. Identities = 10/72 (13%), Positives = 20/72 (27%), Gaps = 5/72 (6%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSD-AYFVLRDGAA--GVFLAANTFPKSRET--RAPLVE 798 + G + C K + A L+ G ++ N FP + + Sbjct: 639 QEGADGSAPSHGIIQSIFQCPKCNEAPLALKPKKNQQGWYIGCNNFPDCKNAVWLPTECK 698 Query: 799 ELYRFRDRLPEK 810 + + P Sbjct: 699 DASVLDECCPTC 710 >UniRef50_C6XEP4 DNA topoisomerase I n=1 Tax=Methylovorus sp. SIP3-4 RepID=C6XEP4_METSD Length = 590 Score = 526 bits (1354), Expect = e-147, Method: Composition-based stats. Identities = 237/643 (36%), Positives = 336/643 (52%), Gaps = 60/643 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+IVESP KAK +++YLGS+Y+VK+S GH+RDLPT ++ + P+ Sbjct: 1 MSKTLIIVESPTKAKKLSEYLGSEYLVKASFGHVRDLPT-----------SNGEIGYHPE 49 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +E YEV + LK ++ D + LATD DREGEAI+ Sbjct: 50 T-----------------FEPIYEVTEKARTTIKVLKAAVKECDRVLLATDPDREGEAIS 92 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL E++G RV F+EIT +AI +A N P ++ V AQ+ARR +DR VG++VS Sbjct: 93 WHLAELLGLRKRE--RVKFHEITASAILKAINTPSAIDTSLVRAQEARRIIDRQVGWLVS 150 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 L +KI + SAGRVQS A+ LVVEREREI AF E F+ V+A + G Sbjct: 151 GPLTRKIGQRASAGRVQSPALALVVEREREILAFKKEAFFTVEAEFSEEWGAVWP----- 205 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + ++ + E ++SVLE + P PF TS L QAAS LGF Sbjct: 206 --SDEQQCKDRSVAETIA---ESKQFSVLEYDLSKLHEDPPPPFRTSKLLQAASVVLGFD 260 Query: 301 VKKTMMMAQRLYEAG-YITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKE 359 K+TM +AQ L++ I+Y RTD +N+S DA M+ Y + + + Sbjct: 261 PKRTMDLAQSLFQKHGAISYHRTDESNISDDAYGMIVEYGQERNYP--MSSEKRTWKGVV 318 Query: 360 NSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG- 418 +QEAHEAIRPSD+N + + M AD LY+LI + VA QM PA+Y T T+ Sbjct: 319 AAQEAHEAIRPSDMNYQPD--ETMTADEAALYRLIHSRAVASQMEPAEYTVATATLSNEQ 376 Query: 419 DFRLKARGRILRFDGWTKVMPALRKGDEDRIL---PAVNKGDALTLVELTPAQHFTKPPA 475 + KA+ + L GW + + D++ L P ++ G L +T +H T+PP Sbjct: 377 GIKFKAQSKSLCKPGWRVLAVQDEEHDDNPSLSHIPDLSVGQILHSSNVTVCEHSTRPPK 436 Query: 476 RFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFR 535 R+++ASL LE+ GIGRP+TYAS++ + DR YV+V R E +G + D L+ F Sbjct: 437 RYTKASLTNALERLGIGRPATYASMVDGLTDRSYVQVVERFLTPEPVGFAIYDALKGAFS 496 Query: 536 ELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLT 595 + ++T ME+ LD + + +++V+ +SD T +L G P T Sbjct: 497 -FIETEYTRGMESDLDLIVKGDKTYRSVVSSKYSDLTTELASFG-----GAEIPRPAPST 550 Query: 596 SIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVP 638 CP CG+ M RT S G FLGCSGY +CK T L Sbjct: 551 VGSCPKCGKGMVQRTGSRGPFLGCSGYP-----KCKETQQLPK 588 Score = 61.7 bits (148), Expect = 1e-07, Method: Composition-based stats. Identities = 57/427 (13%), Positives = 110/427 (25%), Gaps = 52/427 (12%) Query: 407 KYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPA-VNKGDALTLVELT 465 + + + W V P+ + +DR + + + +++E Sbjct: 174 VVEREREILAFKKEAFF-TVEAEFSEEWGAVWPSDEQQCKDRSVAETIAESKQFSVLEYD 232 Query: 466 PAQHFTKPPARFSEASLVKE------------------------------LEKRGIGRPS 495 ++ PP F + L++ ++ I + Sbjct: 233 LSKLHEDPPPPFRTSKLLQAASVVLGFDPKRTMDLAQSLFQKHGAISYHRTDESNISDDA 292 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVT-DRLEENFRELMNYD----FTAQMENSL 550 Y I+ Q+R Y +R G + + E MNY TA E +L Sbjct: 293 -YGMIVEYGQERNYPMSSEKR---TWKGVVAAQEAHEAIRPSDMNYQPDETMTAD-EAAL 347 Query: 551 DQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRT 610 ++ + A + + A E+G Q Sbjct: 348 YRLIHSRA-----VASQMEPAEYTVATATLSNEQGIKFKAQSKSLCKPGWRVLAVQDEEH 402 Query: 611 ASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMD 670 ++ R P +M Sbjct: 403 DDNPSLSHIPDLSVGQILHSSNVTVCEHSTRPPKRYTKASLTNALERLGIGRPATYASMV 462 Query: 671 SYLIDPKR-KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV-ECEKCGSEMHLKMGRFGKY 728 L D ++ P G+ I + + + ++ +K + + Sbjct: 463 DGLTDRSYVQVVERFLTPEPVGFAIYDALKGAFSFIETEYTRGMESDLDLIVKGDKTYRS 522 Query: 729 MACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPK 788 + + T G P P P C K V R G+ G FL + +PK Sbjct: 523 VVSSKYSDLTTELASFGGAEIP---RPAPSTVGSCPKCGKGMVQRTGSRGPFLGCSGYPK 579 Query: 789 SRETRAP 795 +ET+ Sbjct: 580 CKETQQL 586 >UniRef50_A4HPI6 DNA topoisomerase n=9 Tax=Trypanosomatidae RepID=A4HPI6_LEIBR Length = 951 Score = 525 bits (1353), Expect = e-147, Method: Composition-based stats. Identities = 159/873 (18%), Positives = 285/873 (32%), Gaps = 89/873 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVK----SSVGHIRDLPTSGSAAKKSADSTSTKTA 56 M L + E P+ AK + + L + S + + G ++ Sbjct: 1 MPTWLNVAEKPSVAKEMAQSLSGGHCRTVQSQSRFNPVFEFNFEG-----KTMLVTSVVG 55 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHYE--VLPGKEKVVSELKQLAEKADHIYLATDLDR 114 + N + A V E V L+ LA +AD + L D DR Sbjct: 56 HLMEDQFPPNTKNWSTYPFQGLFSAPISKYVRTDLEPVKKNLEALATRADALILWLDCDR 115 Query: 115 EGEAIAWHLREVI--GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 EGE I + + +V+ + R F+ +T + A + + +A +AR+ MD Sbjct: 116 EGENICFEVMQVVQSKRPQVQVKRAHFSALTARDLLNAVHNLKLPDKRLSDAVEARQEMD 175 Query: 173 RVVGYMVSPLLWKKIA-------RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G + K LS G Q + VV R + + FVPE+F+ + Sbjct: 176 LRIGATFTRYQTVKFRHLFAEVPGVLSFGPCQFPTLGFVVRRYWKQQGFVPEDFFTLQVQ 235 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 + + Q + Q AA E + + + +P+ +P P Sbjct: 236 HGDTKFYSSRGSLYDQVAATLIYEDMLQAAAA----EGHKGRITNVQQRPSRRRPPVPLA 291 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLS---QDAVNMVRGYISDN 342 T +Q+ A+T L ++ M +A+ LY+ G I+Y RT++ + + + + ++R I++ Sbjct: 292 TVIMQKLAATHLRISSERCMTLAESLYQEGLISYPRTETDSYTFQESELLELIRLQIANP 351 Query: 343 FGKKY-------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ-KLYQLI 394 +Y + + +AH I P+ D + LY LI Sbjct: 352 DVAEYATAMLADIAARVRPPLRGGHDDKAHPPIHPTKAWNA-------TRDERGSLYNLI 404 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVN 454 R F+A A +T ++ G G + GW + P R +P Sbjct: 405 VRHFLASLSPDAVAATTRVSAEFGGESFSTGGTTIVQRGWLDIFPYERWDS--TCIPNYQ 462 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN 514 GD + + T P +E+ L+ ++ GIG +T A I T+ DR YVR E Sbjct: 463 IGDTFEPTAVLLKKGRTSAPPHLTESRLISLMDSNGIGTDATIAQHIKTVLDREYVRREG 522 Query: 515 RRFYAEKMGEIVTDRLEENF-RELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQ 573 + +G + E L+ AQME ++ +AN A V+ + + Sbjct: 523 QSLVPTTLGIALASAYESLGLASLLQPQLRAQMELAMGDIANGAATKAQVVAAAVQLYEE 582 Query: 574 QLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYAL--------P 625 + + + + + T ++ + + C + Sbjct: 583 IFSRLMASTGAFYEELKRHLRLAAETDTHAVQVTVVKDNFIQCGTCGRHMDLVERAGERD 642 Query: 626 PKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGN 685 + ++ + G + CP CG + K+ + Sbjct: 643 HDREVWSVRCRGCN-KMHRLPNGRLNTLEPVNPPHTCPLCGFVVLRVTNREKQTSYHVC- 700 Query: 686 NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRN 745 P C G G G + + CT +C + + Sbjct: 701 -PHCFGSPPRAWNVTGCGTAGADALLPDIEAAAEFR------CFQCTA-DCPLAKGLEAI 752 Query: 746 GEVAPPKEDPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFR 804 G C LR G G FL+ +P + + Sbjct: 753 GITT-------------CIACHQHELRLRPGPNGFFLSCRGYPSCHLSVS---------- 789 Query: 805 DRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQ 837 LP Q+ P N ++ F +Q Sbjct: 790 --LPAAASVKPSPSQRCPACNAVLLTFDFSGRQ 820 >UniRef50_Q1AUL7 DNA topoisomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AUL7_RUBXD Length = 702 Score = 525 bits (1352), Expect = e-147, Method: Composition-based stats. Identities = 176/708 (24%), Positives = 296/708 (41%), Gaps = 58/708 (8%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+I E A+ I ++L V + G R +P + + + Sbjct: 3 LIISEKANAARKIAQFLAEGPVKE---GKHRSVPYHTFTWRGEECVSVGLKGHVLNPEYP 59 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 N VDP +A ++ V + ++ LA+KAD + +ATD DREGE I Sbjct: 60 EEYSNWQKVDPRELIDARILKSVSEKGVAAAVRSLAKKADRVIIATDFDREGELIGVEAL 119 Query: 125 EVIGGDDA----RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 + + R F+ +TK + +AF E++ + +A +AR+ +D + G ++ Sbjct: 120 SLAFEANPALMDHVERARFSALTKGEVTRAFENLVEVSRELADAGEARQDIDLIWGATLT 179 Query: 181 PLLWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 + + + R LS GRVQS + L+ ERE E +AFVPE +WEV+A G +A Sbjct: 180 RWVSRAVKRYGSAFLSVGRVQSPTLVLIAERELERRAFVPEPYWEVEARLQNGGGPFVA- 238 Query: 237 QVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 R + + + A+ L V E + T APF T+ AA+ Sbjct: 239 -----RHARGRFKEEAEARRALENL-SETAVVTEVRQREATRPAPAPFNTTAFLTAAANI 292 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-VNMVRGYISD-----NFGKKYLPE 350 G + +A+ LY GYI+Y RTD+T + + V G++++ ++ + L Sbjct: 293 -GVSPSRAARIAEDLYTEGYISYPRTDNTVYPESLDLREVLGFLAEVEGVGDYAGRLLGA 351 Query: 351 SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDS 410 H I P+ AE + D K+YQL+ R+F+A PAK Sbjct: 352 GRLTPTRGRRQTTDHPPIYPTGRASRAE----LREDQWKIYQLVVRRFLATLSGPAKTLR 407 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 TTL +G L A G ++ +GW V R+ DE+ LP +++GD + + E Sbjct: 408 TTLRFESGGEPLVAGGTVVTEEGWLAVYHYGRRRDEE--LPRLSEGDEVRVAEAELLAKE 465 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 T+PP R+ + L++ +E G+G +T II + DRGY+ + G V L Sbjct: 466 TQPPGRYGQGRLIRLMEDLGLGTKATRPGIIQNLYDRGYIH--GDPIVPTETGMAVAKAL 523 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 ++ E+ +++ TA++E S+D ++ +V++ + D E E+ Sbjct: 524 KDFASEIASHEMTARLEKSMDAISEGRVSKDSVVEESRELLRRVYDHLESSEEKFADIVW 583 Query: 591 Q---MVLTSIDCPTCG--RKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 T CP CG + + F GC GY C+TT L + +++ + Sbjct: 584 NGIRGDETLGPCPNCGRNLVVRRNRRNRKRFAGCEGYP-----ECRTTFPLPQKGDIIPL 638 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYE 693 C CG + + R+ V N C + Sbjct: 639 -------------GTACEACG--LPEIKVLGGRRPWVTCINMDCPKKQ 671 >UniRef50_B2JJU0 DNA topoisomerase n=93 Tax=Bacteria RepID=B2JJU0_BURP8 Length = 908 Score = 525 bits (1351), Expect = e-147, Method: Composition-based stats. Identities = 180/845 (21%), Positives = 308/845 (36%), Gaps = 115/845 (13%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M KAL+I E P+ A I + LG D+V+ S+VGH+ ++ K Sbjct: 23 MSKALIIAEKPSVANDIARALGGFTKHDEYFESDDFVLSSAVGHLLEIAAPEEYEVKRGK 82 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK--ADHIY 107 + P + E + L +L ++ D + Sbjct: 83 WSFANLPVIPPH-------------------FDLNPIAKSESRLKVLNKLIKRKDVDRLI 123 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQ 165 A D REGE I + + R+ +T AIR+ F + +A Sbjct: 124 NACDAGREGELIFRLIAQHAK-AKQPVQRLWLQSMTPAAIREGFAQLRTDAEMQPLADAA 182 Query: 166 QARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 + R D +VG + + ++G + GRVQ+ + +VVERE +I+ FVP ++W Sbjct: 183 RCRSEADWLVGINGTRAMTAFNSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYW 242 Query: 221 EVDASTTTPSGEALALQVTHQNDKPF--------RPVNKEQTQAAVSLLEKARYSVLERE 272 EV A SG + K R + + V+ +V E E Sbjct: 243 EVKAEFVCASGFYEGRWYDPKFKKDEFDPEKRDSRLWSLPAAETIVAACRGQTGNVTE-E 301 Query: 273 DKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDA 331 KP+T A F ++LQ+ A+ R GF K T+ +AQ LYE + TY RTD+ L +D Sbjct: 302 SKPSTQLSPALFDLTSLQREANGRFGFSAKNTLGLAQALYEKHKVLTYPRTDARALPEDY 361 Query: 332 VNMVRGYIS-DNFGKKYLPE----------SPNQYASKENSQEAHEAIRPSDVNVMAESL 380 + V+ + YLP PN+ + H AI P+ ++ Sbjct: 362 LETVKHTMEMLKESNNYLPHAKQVLDKGWVKPNKRIFDNSKISDHFAIIPT-----LQAP 416 Query: 381 KDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPA 440 K + QKLY L+ ++F+A A+Y TT K G++L GW +V Sbjct: 417 KALSEPEQKLYDLVVKRFLAVFFPAAEYRVTTRITEVVGHHFKTEGKVLVEPGWLQVYGR 476 Query: 441 LRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE------------- 487 G++ ++P V K + + ++ Q TKPPAR++EA+L+ +E Sbjct: 477 ETGGEDANLVP-VQKDEKVKTDKIAAQQLVTKPPARYNEATLLSAMEGAGKLVEDDELRE 535 Query: 488 ---KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENF-RELMNYDFT 543 +G+G P+T A+II + Y+ E R + L +EL + T Sbjct: 536 AMAAKGLGTPATRAAIIEGLLGEKYLVREGRELIPTAKAFQLMTLLRGLDVKELTAPELT 595 Query: 544 AQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCG 603 + E L Q+ + A + + +A++ + + T CP CG Sbjct: 596 GEWEYKLSQMERGKLPRDAFMQEIARMTQTIVKRAKEYDSDTIPGDYATLQT--PCPNCG 653 Query: 604 RKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPE------NEVLNVLEGEDAETNALR 657 ++ Y +C+ +++ +P EV +L+ + + Sbjct: 654 GQVK------------ENYRRFACTKCEFSMSKIPGGRQFEIEEVEELLQKKQIGPLSGF 701 Query: 658 AKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSE 717 + + D + + + G E E P+ C KC + Sbjct: 702 RSKMGRPFSAILKLSFDDETKNFKLEFDFGQDQGGEDGEAPD--FSEQQPVGACPKCSGK 759 Query: 718 MHLKMGRFGKYMACTN-----EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVL 772 + G C N + C + + ++ L + + Sbjct: 760 VFE----HGMSYVCENSVANPKTCDFRSGKVILQQEIAREQMAKLLENGRTDLLTNFKSS 815 Query: 773 RDGAA 777 R G Sbjct: 816 RTGRN 820 >UniRef50_O66893 DNA topoisomerase 1 n=2 Tax=Aquificaceae RepID=TOP1_AQUAE Length = 540 Score = 524 bits (1350), Expect = e-147, Method: Composition-based stats. Identities = 217/574 (37%), Positives = 319/574 (55%), Gaps = 52/574 (9%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L IVESP KAKTI K+LG ++VK+++GH++DLP Sbjct: 3 LFIVESPTKAKTIQKFLGKGFLVKATLGHVKDLPEKE----------------------- 39 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 +GVD +A Y GK+K+V +LK+L+ ++ +YL TD DREGEAIA+ L+ Sbjct: 40 ------LGVDLRTL-KAKYVYKRGKKKLVEQLKKLSRRSSIVYLGTDPDREGEAIAYFLK 92 Query: 125 EVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW 184 + + + R VF EIT AIR++ G++N++ V AQ ARR +DR++GY++SP+LW Sbjct: 93 KDLEKVNKNIKRAVFYEITPEAIRESIRNAGDVNMNLVYAQFARRILDRLIGYLISPILW 152 Query: 185 KKIAR-GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 K+ LSAGRVQS A+RL+VEREREI+ F ++++ V A S E A+ Sbjct: 153 KEFKNYKLSAGRVQSPALRLIVEREREIQNFKVKKYYYVKALLRKGSEEFWAIY------ 206 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 +R N + LEK +SV + E K P PFITS LQ A+ + GF ++ Sbjct: 207 -DYRYENPSDAKIIAKKLEKGYFSVYKVEKKKEKVSPPKPFITSDLQSEANAKFGFSSER 265 Query: 304 TMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQE 363 T +AQ LYE GYITY RTDS +++ YI +GK+Y+ ++ K +Q Sbjct: 266 TQKLAQELYEKGYITYPRTDSYRMNEKKAKEFMNYIEKKYGKEYVG-RLRRFREKATAQG 324 Query: 364 AHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGA------ 417 AHE IRP+ + +++ + LY LI+R+ +A M + +TV A Sbjct: 325 AHECIRPTSLREEIPEREEL----RLLYDLIFRRTIASLMKEMLLEREKVTVEAITPELK 380 Query: 418 GDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARF 477 L A+G + FDGW++V P+ + LP + +GD L LV+ T + T+PP R+ Sbjct: 381 HPVYLVAKGLKIVFDGWSRVYPS---EITEEKLPELYEGDLLDLVKTTLEERKTQPPPRY 437 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFREL 537 +E +L+K LEK GIGRPSTYA+I+ T+++RGYV V+ + ++ V + L E F L Sbjct: 438 TEGTLIKTLEKLGIGRPSTYATIVKTLKERGYVEVKKKALVPTEIAFQVVEFLMERFPTL 497 Query: 538 MNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 M+Y FTAQME LD V + WK+V+ F Sbjct: 498 MDYKFTAQMEEKLDLVEEGKLNWKSVVYEFMEKI 531 >UniRef50_A4BJY7 Topoisomerase I n=1 Tax=Reinekea blandensis MED297 RepID=A4BJY7_9GAMM Length = 713 Score = 523 bits (1347), Expect = e-146, Method: Composition-based stats. Identities = 238/727 (32%), Positives = 335/727 (46%), Gaps = 68/727 (9%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+IVESP K K I +YLG+ ++VK+SVGHIRDLP Sbjct: 2 KLMIVESPNKCKKIAEYLGAGWMVKASVGHIRDLP------------------------- 36 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +GVD + + Y + GK KVV +L+ A KAD ++LATD DREGEAIA+H+ Sbjct: 37 ----QKDLGVDVENRFRPAYVISEGKHKVVKDLQAAAAKADEVWLATDPDREGEAIAYHI 92 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 R V+G D Y RV FNEI K +I++A P +LN+ V AQ+ RR +DR+VGY VSP L Sbjct: 93 RTVLGLKD-NYKRVTFNEINKGSIQKALASPRKLNMQMVAAQETRRILDRLVGYTVSPAL 151 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQND 243 + + G+SAGRVQS AVRLVV+REREI+ F P++ + A T +G + L + Sbjct: 152 QAQSSAGMSAGRVQSPAVRLVVDREREIQGFTPQDHYT--AVITLDNGLEMKLDTKPLQN 209 Query: 244 KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKK 303 + A + L + + +P P F TS LQQ AST+LG + Sbjct: 210 AEGLVTDPAIIDAILHPLSD--VIITKAATEPKQVNPKPVFTTSELQQVASTKLGLSPDQ 267 Query: 304 TMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENSQE 363 TM AQ L+EAG ITY RTD NLS D M+ Y+ G PE A N+QE Sbjct: 268 TMKQAQSLFEAGRITYHRTDDPNLSDDGWAMIAAYLESQ-GIPVSPERRKWKAKDANAQE 326 Query: 364 AHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG----- 418 AHE IRP+ + D +LY+LI+ + +A ST + A Sbjct: 327 AHEGIRPTSMTDEPGQ-----GDTDQLYRLIYERAMAAVTVNGVDISTQVIAKATLDLDV 381 Query: 419 DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF-TKPPARF 477 KA G+++ GW ++M +D L V D + V + T PPAR+ Sbjct: 382 PVEFKASGKVVETMGWRQLMTIEVAESKDTQLKCVPDVDQVCAVAAKSRKDQVTTPPARY 441 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRLEENFRE 536 +EASLVKELEKRGIGRPSTYA+I + R Y+ V + R+ +G V D L E Sbjct: 442 TEASLVKELEKRGIGRPSTYATIFVNVFRRQYLEVGKGRQITPTPLGVAVVDALMSM--E 499 Query: 537 LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTS 596 M+YD+TA +E+ LDQ+ + V+ + +D K T Sbjct: 500 FMDYDYTANLESQLDQMVEGRLKLLDVVGPAYQQI---VDDLPKVSVNQSSISQFEQGTQ 556 Query: 597 IDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAET-NA 655 C CG + PK+ ++ ++ + A Sbjct: 557 EACIQCGHPIKRLPKK-----------SNPKQFFWVHVDEAHAEGCEKFIDDMRGKPYMA 605 Query: 656 LRAKRRCPKCGTAMDS-YLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKC 714 +C C ++ Y R V ++ C ++ + P C C Sbjct: 606 DLQSHQCKLCNGDLERAYSKAKNRHFWVHKDDSDCAKRTYQDRSGKPVLDALP---CPGC 662 Query: 715 GSEMHLK 721 G + + Sbjct: 663 GFALVRR 669 >UniRef50_A5ZSZ0 DNA topoisomerase n=12 Tax=Bacteria RepID=A5ZSZ0_9FIRM Length = 703 Score = 523 bits (1347), Expect = e-146, Method: Composition-based stats. Identities = 149/720 (20%), Positives = 262/720 (36%), Gaps = 95/720 (13%) Query: 5 LVIVESPAKAKTINKYLG-----SDY------VVKSSVGHIRDLPTSGSAAKKSADSTST 53 LVI E P+ ++ I + +G Y +V GH+ + + + +K Sbjct: 3 LVIAEKPSVSRAIAEVIGAQEREDGYLQGTDCMVSWCFGHLAEYVSPDAYDEKFNQWRYE 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAE--KADHIYLATD 111 PK + V K+ LK+L + +++ A D Sbjct: 63 DLPIIPK-------------------DWKVTVSEDKKDQFYILKRLLNSPEIEYVVNACD 103 Query: 112 LDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQQARR 169 REGE I H+ + + G R+ + + +AI E A R Sbjct: 104 AGREGELIFKHVYD-LSGSKKPVKRLWISSLEDSAILDGMQHLRSAEEYRHLAEAAVCRS 162 Query: 170 FMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 D +VG + K + L+ GRVQ+ + ++VER +I F E+++ V+ Sbjct: 163 QADWLVGMNATRAYTTKYFKKLTVGRVQTPTLAMLVERAGQISNFQKEKYFNVELDCDGI 222 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTL 289 + + ++ + S + + V ++ K + +TL Sbjct: 223 PAV------------KPKIFDPDEAEQLRSRCQGSEAIVTAVKETEKKVKAPKLYDLTTL 270 Query: 290 QQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 Q+ A+ G K+T+ AQ LYE ITY RTDS L++D R + + K L Sbjct: 271 QREANRIYGMTAKQTLDTAQSLYEKKLITYPRTDSQYLTEDMEQTARNVVRQIYEKYQLT 330 Query: 350 ESPNQYAS-------KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQ 402 +Q + H AI P+ + + + L ++++ +K+ LI V Sbjct: 331 GPFDQPEQPDVKKVMNNSKVTDHHAIIPT-MELASCHLDELKSWEEKILFLIAVHTVMAM 389 Query: 403 MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE----------DRILPA 452 Y T + V + KA+G+I+ DGW + D +P Sbjct: 390 SKDHIYQETEIEVECQEEIFKAKGKIVLQDGWKLFENCFKNKDRMAIVDPDQEMKERMPK 449 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------EKRGIGRPSTYASI 500 V +G V+ +HFT PP +SE +L+ + EK+G+G P+T A I Sbjct: 450 VTQGQTFYAVDAEKTEHFTSPPKPYSEDTLLAAMETAGNKEFDEDTEKKGLGTPATRAGI 509 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 I + Y + ++ G+++ + L + L + TA+ EN L + + E Sbjct: 510 IEKLVYSQYATRKGKQIIPTDDGKVLVEILPDF---LKSASMTAEWENQLLLMEHGEIAP 566 Query: 561 KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCS 620 + + + T L+ + EE R Q + CP CG + + CS Sbjct: 567 EQFMTGIKNMLTMMLNGCDAISEEETRRF-QTRESIGTCPVCGSLVYESKTNF----YCS 621 Query: 621 GYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 + C + +N L +E + A + C D Y Sbjct: 622 NH------DCHFALW--KDNRYLQSMEKNMDKKMAAELLKSG--CVHVKDLYSRKKNMYF 671 >UniRef50_A3FPU5 DNA topoisomerase n=3 Tax=Cryptosporidium RepID=A3FPU5_CRYPV Length = 835 Score = 523 bits (1346), Expect = e-146, Method: Composition-based stats. Identities = 169/878 (19%), Positives = 306/878 (34%), Gaps = 89/878 (10%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVG---HIRDLPTSGSAAKKSADSTSTKTAKKP 59 K L++ E P+ + TI++ L + + H + G + S + Sbjct: 5 KVLMVAEKPSISDTISRILSNGKLDTRRGKTPVHEFNGTFMGMNVQFRVTSVAG---HVF 61 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 + D + N DP ++A K+VS L++ ++ ++ L D DREGE I Sbjct: 62 EIDFPQSYSNWEKTDPVSLFDAPIIKNESSSKMVSHLEKESKGCSYLVLWLDCDREGENI 121 Query: 120 AWHLREVIGGDDAR-------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 + + V+ + ++ R F+ I+ I A N + +A R+ +D Sbjct: 122 CFEVINVVSNNMSKGRDQRDWIFRAKFSSISPGDIFFAMKNLTFPNKNESDAVDVRQELD 181 Query: 173 RVVGYMVSPLLWKKIARG---------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD 223 +G S L K + +S G Q+ + V+R I +F+PE+++ + Sbjct: 182 LKIGVAFSRLQTKYLKSKFGDFNKSSIISYGPCQTPTLFFTVQRRDSINSFIPEKYYTIS 241 Query: 224 ASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 A+ + S + + + + F + + V++ K + P Sbjct: 242 ATLSKDSQD---INLIWSRSRVFELQVANCFLQLIQNKKPLSARVVDITSKNSRRIRPLP 298 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYI---- 339 T ++ + +ST LG G +T+ +A++LY +G+ TY RT+++ ++ ++ I Sbjct: 299 LNTVSMLKLSSTILGIGPFQTLNIAEKLYLSGFTTYPRTETSRYPKNF--DIKSTIAMFK 356 Query: 340 ----SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 ++ L + N H I P + + D++ D+ +LY LI Sbjct: 357 NNSVWGSYSSDLLQKGFNLPRKDGLDLGDHPPITPV----RSATQNDLDGDSWRLYDLIT 412 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNK 455 R F A K + T+ G + G+ V+ E I+P Sbjct: 413 RHFFATISNDIKMINRTIKFDLNGEIFIISGNQVIDHGF-SVIQGRAACHESNIIPDFTL 471 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-EN 514 + + + + TKPP SE+ L+ +EK GIG ++ + I IQ+R YV++ Sbjct: 472 NEVVPIKNIEILSKETKPPPILSESDLLSLMEKHGIGTDASMPTHIQKIQEREYVKLASG 531 Query: 515 RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS----- 569 RR K+G + + EL+ ++ME +D +A + KAVL H S Sbjct: 532 RRLEPTKLGIALVHGIMNIDHELVLPKIRSEMEKYVDLIAKGKYNHKAVLKHSLSVFKLK 591 Query: 570 --DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGY----A 623 F + + E G C C R + + L CS Sbjct: 592 FLYFAENISLFESLFRLGFTNITASCSRISRCGQCKRYLTYISNILPQRLYCSFCEIYLD 651 Query: 624 LPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVC 683 +P + K L + +L D + + CP+C Sbjct: 652 IPQRGTIKIYKELKCPIDDFELLLFIDQKG---KKSIFCPRCYNDPPFLDAKENMLCKF- 707 Query: 684 GNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKIL 743 C P +C G C+ C + I Sbjct: 708 -----CPHQTCNFSLKSTFFMACPSQDCR-DGIITMDSSSTSDWRFDCSR--CSISFSIK 759 Query: 744 RNGEVAPPKEDPVPLPELPCEKSDA---YFVLRDGAAGVFLAANTFPKSRETRAPLVEEL 800 +N CEK + + F+ P E L+E + Sbjct: 760 KNICE-------RLSLGERCEKCGSRKLKICKEKTSQEHFVGC---PNCDEEILSLIEVI 809 Query: 801 YRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQ 838 LP KL Y +D + G ++ K+ Sbjct: 810 S-----LP-KLAYRSDVAKNSFRGG------GKRGKRH 835 >UniRef50_Q9HM08 DNA topoisomerase 1 n=4 Tax=Thermoplasmatales RepID=TOP1_THEAC Length = 770 Score = 522 bits (1345), Expect = e-146, Method: Composition-based stats. Identities = 157/818 (19%), Positives = 286/818 (34%), Gaps = 80/818 (9%) Query: 6 VIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDERG 65 +I E + I +L V + S + + D Sbjct: 7 IIAEKADAGRRIAYFLSGGQVKSHRA---KGTSYLEFEYNGSKTYLIPLSGHIVEADFES 63 Query: 66 ALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLRE 125 + +D +A + L+ K + I +ATD DREGE I + Sbjct: 64 GYSDWNKIDLSDLIDARIVKNIKNKVAYQTLQAFRGKVEEIVIATDYDREGELIGVEALD 123 Query: 126 VIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWK 185 +I R F+ +TKN I +F +N +A AR +D + G +++ Sbjct: 124 IIKEGKEEIRRAKFSALTKNEILDSFKNLIGVNYSLADAADARESIDLIWGSVLTRFFSV 183 Query: 186 KIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTHQ 241 R LSAGRVQ+ + +VV+REREI++F PE +W + + + Sbjct: 184 TTGRLGKSFLSAGRVQTPTLAIVVDREREIQSFRPERYWTISITFDKDG--------QFK 235 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 P +++ + ++ V K + APF T+ + AS G Sbjct: 236 ARYPENIKDQDTAEKIYEAIKGKNGRVSSYTSKEDHIRRPAPFSTTEFLREASRI-GIMP 294 Query: 302 KKTMMMAQRLYEAGYITYMRTDSTNLS-----QDAVNMVRGYISDNFGKKYLPESPNQYA 356 K M +A+ LY G I+Y RTD+T + + + + K+ + Sbjct: 295 TKAMSIAENLYMRGLISYPRTDNTVYPRSINLKSVLKKLENTAYSKYVKEIETFDRILPS 354 Query: 357 SKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVG 416 H I P D + ++ D ++Y LI R F++ K + Sbjct: 355 RGRIETTDHPPIYPVDSPK-----EQLKGDYGRVYDLILRHFLSTLYRDGKKTVAEAEIY 409 Query: 417 AGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPAR 476 + KA G+ GWT++ K D LP + +G+ L ++ + TKPP R Sbjct: 410 VNGYTFKAAGQHTTDRGWTEIYGYDPK---DVYLPELTEGEDLKAIDWNIQREETKPPPR 466 Query: 477 FSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE 536 + +SL+K++E+ +G ST II + +RG++ +G D + Sbjct: 467 YDMSSLLKKMEELNLGTKSTRHDIIGKLIERGFIE--GNPVKPTPLGMAFIDAVRSVNSH 524 Query: 537 LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTS 596 + + + TA++E +D++ +E V++ + L + + + Sbjct: 525 IADPEMTAKLEEDMDRIEKNEMSKNDVVEESKKMLHEVLSHFLTKTADVKDIITKGINAG 584 Query: 597 IDCPTC----GRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 + C G+K+ + + C CK + Sbjct: 585 QEIGDCPFHEGKKIMVIRDRFTYTVRCE------DPSCKINFRIKRNG------------ 626 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECE 712 + + ++CP CG M +I + + +P C E EC Sbjct: 627 -SITLSDQKCPVCGLPMI-KIIRKGQSPEIKCIDPDCSYNRENEDYG----------ECP 674 Query: 713 KCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYF 770 + L+ ++GK ++ C+N +C T + + G + C A Sbjct: 675 ADHGRLVLRQSKYGKRFLGCSNYPKCTVTYPLPQMGRITKT--------GEVCPYCGAPI 726 Query: 771 VL--RDGAAGVFLAANTFPKSRETRAPLVEELYRFRDR 806 + R+G F + + E R Sbjct: 727 LALSRNGRKWKF--CPNM-QCEYNKKRKPEAAVEKSVR 761 >UniRef50_C1LZJ7 Prokaryotic DNA topoisomerase, putative n=1 Tax=Schistosoma mansoni RepID=C1LZJ7_SCHMA Length = 1165 Score = 522 bits (1345), Expect = e-146, Method: Composition-based stats. Identities = 165/868 (19%), Positives = 301/868 (34%), Gaps = 141/868 (16%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 K L + E AK I++ L S I + P + + TS Sbjct: 27 KILNVAEKNDAAKNISEILSRGGYHRREGISKFNKIYEFPMNLNGQNVMMVMTSVS-GHL 85 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYE--VLPGKEKVVSELKQLAEKADHIYLATDLDREG 116 D + +P ++A VL E + L++ + + TD DREG Sbjct: 86 TNYDFLPNYKSWHSCNPMVLFDAPIVKQVLKDYEPIKQTLQREVRSCQKLIIWTDCDREG 145 Query: 117 EAIAWHLREVIG--GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E I + +V + R F+EIT A+ +A ++ + + A R+ +D Sbjct: 146 ENIGVEVIDVCREIKPNIEILRARFSEITPAAVHRAVDRLTIPDYNASTAVDVRQELDLR 205 Query: 175 VGYMVSPLLWKKIARG---------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G + ++ R +S G Q + VVER RE+ FV E FW + + Sbjct: 206 IGAAFTRFQTLRLRRVFPQALSDQLISYGSCQFPTLGFVVERFREVDQFVSEPFWRIVVT 265 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLL-EKARYSVLEREDKPTTSKPGAPF 284 + + Q R +++ +A L + ++E +P T Sbjct: 266 VSRDE---KTTEFQWQRG---RLFDQDCCRAYYEHLNQNRYGQIVEVIKRPKTKWRPTAL 319 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYI----- 339 T L++ AS +L G K M +A+RLY G+I+Y RT++ D ++ + Sbjct: 320 DTVELEKLASRKLQMGAKYAMQLAERLYNKGFISYPRTETKIFPPDL--DLKSLVHVQIN 377 Query: 340 ---SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWR 396 +F + L PN + ++S +AH I P V ++ D +LY+L+ R Sbjct: 378 DSRWSDFATRILERGPN-PKNGKSSDKAHPPIHPLKVGDS------LQGDEARLYELVTR 430 Query: 397 QFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKG 456 F+AC T A+ T + + +++G ++ + +V R ++D +P G Sbjct: 431 HFLACLSTDAEGAETIVRLCIDGELFESKGLMILALNYLEVYIYDRWAEKD--MPVFQLG 488 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE-NR 515 + + + T PP +EA L+ +++ GIG +T+A I TI+ R YV +E N+ Sbjct: 489 EWILPDNIQVLTGQTCPPPLLTEADLISLMDRHGIGTDATHAEHIETIKQRLYVGLEQNK 548 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH----FFSDF 571 ++G + + + E+ + ++ E L + + VL H + F Sbjct: 549 FLVPGQLGMGLVEGYDSMGFEMSKPNLRSEFEADLKLICEGRKTKEEVLHHHLNKYKELF 608 Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSID--------------------------------- 598 L++A +R Q + Sbjct: 609 RLALNQASFLDRALALRLEQEAENVQNISGSVGEMASFAASNNTIDGHNQSNVLNPVVAF 668 Query: 599 CPTCGRKMGIRTAST--------------------------GVFLGCSGYALPPKERCKT 632 CPTC + +R + G FL CSGY C+ Sbjct: 669 CPTCHSGLVLRQKRSALRPLTTSSNLSNNSGSNEVNQTSNGGWFLSCSGYP-----NCRY 723 Query: 633 TINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDP--------------KR 678 I + VL + + C +C + S + P +R Sbjct: 724 AIWFPDSVIHVRVL--------SETNENTCNRCADFIPSSSVRPSNDQLRPLKLGLRFRR 775 Query: 679 KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKM---GRFGKYMAC---T 732 ++ D + D + C ++ +K + + C Sbjct: 776 NFYLPNGYIQDDDTKESVDNAEAGDSDNILCNCGHSAIQLTVKKPGPNQGRLFYRCPGLA 835 Query: 733 NEECKNTRKILRNGEVAPPKEDPVPLPE 760 C + + + P+ Sbjct: 836 GNSCDFFLWKSQTTPITIAQSSPLYSST 863 >UniRef50_A3DB61 DNA topoisomerase n=1 Tax=Shewanella baltica OS155 RepID=A3DB61_SHEB5 Length = 707 Score = 522 bits (1345), Expect = e-146, Method: Composition-based stats. Identities = 154/728 (21%), Positives = 267/728 (36%), Gaps = 94/728 (12%) Query: 5 LVIVESPAKAKTINKYLG----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTK 54 L + E P++AK I LG V VGH+ + Sbjct: 3 LFLCEKPSQAKDIASVLGCKRGDGVFTGDGIAVTFCVGHVLQQAEPENYNPDFETWNIVD 62 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 P V P + + +K+ KA + +ATD DR Sbjct: 63 LPIIPTV-------------------WKMLVSPKTKAQFAIVKKQLAKATEVIIATDADR 103 Query: 115 EGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI--DRVNAQQARRFMD 172 EGE IA + E + R+ + + +I++A + +A R D Sbjct: 104 EGEVIAREVLEYV-NYKGPIQRLWLSALDDASIKKALASLRPNHETAKLYDAGLGRSRGD 162 Query: 173 RVVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST- 226 ++G ++ L S GRVQ+ +RLVV+R+ +++ F P+ ++++ Sbjct: 163 WLIGMNMTRLCTLLSREYGYQGAFSVGRVQTPTLRLVVDRDSQVEQFEPQSYYDITGLFN 222 Query: 227 TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFIT 286 T +A + D+ R + +S +V + + K SK F Sbjct: 223 ATIPFKAKWQVPDNLGDEQGRCLQVTTVDHVLSQCRDQPGTVTQFDTKRQKSKHPPLFFL 282 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRGYISDN--- 342 +LQ+A S + G+G K+ + +AQ LYE TY RTD L V + Sbjct: 283 GSLQKAMSAKFGYGAKEVLDIAQSLYEKYKVTTYPRTDCPYLPLSQKEEVGSILDKLKVV 342 Query: 343 --FGKKYLPESPNQYA--SKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 F N+ + + AH I P + L +M LY I +++ Sbjct: 343 PAFAAWCSAADVNETSACWNDKKITAHHGIIP---LPVTPKLHEMNEKELNLYHAIVQRY 399 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG---DEDRILPAVNK 455 +A A+ D+TT+ + G +KA G++ R GW V + D+ LP ++ Sbjct: 400 LAQFYPVAEDDATTIELMVGSQSVKATGKVERVKGWRLVTGKDSEDETTDDSANLPLLSI 459 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYA 498 G LT + TKPP RF+E +L+ + E GIG +T A Sbjct: 460 GQTLT-AQFQREDKRTKPPGRFTEGTLIDAMSNIAKFESDPKLKSILKETSGIGTEATRA 518 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 +II T++ RG+V V ++ + + G + D L + L TA E +LD++A Sbjct: 519 NIIDTLKARGFVTVTGKQLISSEAGRSLIDALPDV---LTRPAMTALWEQALDEIALGNG 575 Query: 559 EWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG 618 + + TQ + ++ + ++ +++ ++ CP C + M + G F Sbjct: 576 SLDDFMARQSTFITQLVSMFKQG--QYTLKLPKVLAVTLPCPVCQKSMKQLSGKNGKFWV 633 Query: 619 CSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR 678 C + E +L ++ C K G + + Sbjct: 634 CE------------------DKEQCGLLLNDERGKLPKTTPCTCKK-GVLVRKKAKTKGK 674 Query: 679 KLHVCGNN 686 C Sbjct: 675 FWWGCSAY 682 Score = 48.6 bits (114), Expect = 0.001, Method: Composition-based stats. Identities = 19/130 (14%), Positives = 35/130 (26%), Gaps = 6/130 (4%) Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCD 690 + + + + + L CP C +M K VC + C Sbjct: 583 RQSTFITQLVSMFKQGQYTLKLPKVLAVTLPCPVCQKSMKQL-SGKNGKFWVCEDKEQCG 641 Query: 691 GYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKY-MACTNEECKNTRKILRNGEVA 749 +E K K G + K GK+ C+ + R++ N Sbjct: 642 LLLNDERGKLPKTTPCTC----KKGVLVRKKAKTKGKFWWGCSAYQSGCQRRLFDNEGKP 697 Query: 750 PPKEDPVPLP 759 + + Sbjct: 698 GKEMESNNQT 707 Score = 45.5 bits (106), Expect = 0.009, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 21/79 (26%), Gaps = 13/79 (16%) Query: 711 CEKCGSEMHLKMGRFGKYMACTNEE-CKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY 769 C C M G+ GK+ C ++E C R C Sbjct: 614 CPVCQKSMKQLSGKNGKFWVCEDKEQCGLLLNDERGKLPKTTP----------CTCKKGV 663 Query: 770 FVLRDGA-AGVF-LAANTF 786 V + G F + + Sbjct: 664 LVRKKAKTKGKFWWGCSAY 682 >UniRef50_C7H9Z3 DNA topoisomerase n=32 Tax=Firmicutes RepID=C7H9Z3_9FIRM Length = 707 Score = 522 bits (1345), Expect = e-146, Method: Composition-based stats. Identities = 130/694 (18%), Positives = 247/694 (35%), Gaps = 103/694 (14%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M LVI E P+ A++I +G Y+V +GH+ +G +K Sbjct: 1 MSFQLVIAEKPSVARSIAAVIGATEKQNGYWQGGGYLVSWCIGHLVSFAEAGQYDEKYCK 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEK--ADHIY 107 P+ + V K++ ++ L + D + Sbjct: 61 WRYEDLPILPQP-------------------WQFIVPDEKKQQFEIVRSLLNRPDVDSVT 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQ 165 ATD REGE I + ++ G R+ + + AIR+ F + Sbjct: 102 AATDAGREGELIFRFVYQMAGC-TKPVKRLWISSMEDAAIREGFANLRPDSDYDALYQSA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 R D +VG + L + L+ GRVQ+ ++++V+R+ +I F E+++ V Sbjct: 161 LCRAKADWLVGINATRLFSVLYHKTLTVGRVQTPTLKMLVDRDAKILRFQKEKYYTVGIQ 220 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 + + ++ R + E A + + T +P + Sbjct: 221 SGSLKADS------------ERISDAEAANLLKEKCTGANAVCVSIRREKKTEQPPKLYD 268 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDN--- 342 +TLQ+ A+ GF K+T+ AQ+LYE +TY RTDS L++D + +SD Sbjct: 269 LTTLQREANRLFGFTAKQTLDYAQQLYEKKLLTYPRTDSQYLTEDMGRTAQHLVSDLLGL 328 Query: 343 --FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 F + + H AI P+ + + + KL L+ + + Sbjct: 329 LPFAQGLALTAEVGRVLNSKKVSDHHAIIPTS-EFVKQGFTGLAESECKLMNLVCSKLLC 387 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKV---------MPALRKGDEDRILP 451 P +Y++ T A+G+ + GW ++ + + LP Sbjct: 388 AVAAPHEYETVTAVFSCAGNEFAAKGKTVLVPGWKEIDQRFRSTLKTDGEEETETLNTLP 447 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------------------- 486 + +G ++ ++HFT PP ++E +L+ + Sbjct: 448 ELTEGQNFSVTT-DISEHFTSPPKAYTEDTLLSAMERAGAEDMPEDKVNCSAGAREGGLG 506 Query: 487 --EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTA 544 E++G+G P+T A+I+ + G+V+ + ++ K G + L E L + TA Sbjct: 507 QAERKGLGTPATRAAILEKLVQIGFVQRKGKQLVPTKDGINLAVVLPE---SLTSPVLTA 563 Query: 545 QMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGR 604 + EN L ++A A+ + + Q + + + CP C Sbjct: 564 EWENRLTEIAKGNADPDEFMAEIEAQVRQLVKTYSCISADKQNLFQSERVIIGKCPRCSE 623 Query: 605 KMGIRTASTGVFLGCSGYALPPKERCKTTINLVP 638 + + G C+ + Sbjct: 624 NVY--EGKKNFYCG--------NRSCQFVMWKND 647 >UniRef50_A1U3N5 DNA topoisomerase n=6 Tax=Gammaproteobacteria RepID=A1U3N5_MARAV Length = 722 Score = 522 bits (1344), Expect = e-146, Method: Composition-based stats. Identities = 162/758 (21%), Positives = 264/758 (34%), Gaps = 108/758 (14%) Query: 5 LVIVESPAKAKTINKYL------GSDYV----------VKSSVGHIRDLPTSGSAAKKSA 48 L I E P+ A+ I L G ++ V +GH+ + Sbjct: 3 LYIAEKPSLARAIAAALPGPHEKGQGWIRCGKGPDAATVSWCIGHLLEPAEPARYNPAWK 62 Query: 49 DSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYL 108 P+ L+ L KAD I Sbjct: 63 KWRIEDLPMFPEP-------------------WQLTPKDSVRLQFKVLEALVRKADLITH 103 Query: 109 ATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQ 166 A D DREG+ + + +G A R++ N++T A+ +A P + ++ Sbjct: 104 AGDPDREGQLLVDEVLRYLG-TKAPVKRILINDLTPKAVARAIQNPRDNREFRPLSHSAL 162 Query: 167 ARRFMDRVVGYMVSPLLWKKI-----ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 AR+ D + G ++ S GRVQ+ + LVV+R+ I+ F P+ ++ Sbjct: 163 ARQRADWLYGINLTRFYTLSYQTRGEQGVFSVGRVQTPVLGLVVDRDNTIEHFQPKPWYR 222 Query: 222 VDASTTTPSGE-----ALALQVTHQN-----DKPFRPVNKEQTQAAVSLLEKARYSVLER 271 V+A+ E +A + D+ R ++K + V+ + + E Sbjct: 223 VEATFQASEPEADQRPFIARWLPGDEFQDHLDEENRLLDKSVAEQIVAAISGRPGRIDEA 282 Query: 272 EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQD 330 + P P S LQ A G K + AQ LYE ITY R+DS L ++ Sbjct: 283 RFRDRPEPPPLPLSLSALQIEAGRLYRMGAKDVLDTAQNLYERHQLITYPRSDSRYLPEE 342 Query: 331 AVNMVRGYISDNFG--------KKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD 382 + I + A + +AH AI P+ V Sbjct: 343 HFSQREAVIRAIARVAPDLSGFCEKTGTERRSAAWNDQKVDAHHAIIPT---VRPAPNGK 399 Query: 383 MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR 442 + + QK+Y LI R ++ A + LTV D+R +A + GW + R Sbjct: 400 LSSAEQKIYDLISRFYLMQFAPDAVHREGRLTVAIQDYRFRATETAVIEPGWKTLEIRKR 459 Query: 443 K---GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------- 486 + E LP + K + + + + T+PP F++A+L+ + Sbjct: 460 EPGQEPEKAPLPRLEKNEPVLCTDPQTNERKTQPPQHFTDATLLSAMTNIARFVADNELR 519 Query: 487 ----EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDF 542 E G+G +T A+II T+ R Y+ E R A G+ + L E + D Sbjct: 520 KTLRETDGLGTEATRAAIIDTLFRRDYLFREKRFIRATDKGKSLIAALPE---SIRTPDR 576 Query: 543 TAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTC 602 TA E +L+ V E + +A L+ + + +A G+ + T+I CP C Sbjct: 577 TAVWEATLEGVRRGEEDPRAFLESLKDEIRGFMAQAPA----AGLANTETPGTAIHCPKC 632 Query: 603 GRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRC 662 M R G F C+ Y CK T L E E + C Sbjct: 633 RAPMVEREGKFGAFFACTRYPA-----CKGTRPL----------EDHQPEDGTSQKPVPC 677 Query: 663 PKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFR 700 P C + + + C N P C + Sbjct: 678 PHCFSPLVRRKSNKG-WFWGCSNFPGCRQTVDDHNGRP 714 Score = 81.3 bits (199), Expect = 2e-13, Method: Composition-based stats. Identities = 26/87 (29%), Positives = 37/87 (42%), Gaps = 6/87 (6%) Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 + C KC + M + G+FG + ACT CK TR + + ED +PC Sbjct: 625 TAIHCPKCRAPMVEREGKFGAFFACTRYPACKGTRPLEDH-----QPEDGTSQKPVPCPH 679 Query: 766 SDAYFVLRDGAAGVFLAANTFPKSRET 792 + V R G F + FP R+T Sbjct: 680 CFSPLVRRKSNKGWFWGCSNFPGCRQT 706 Score = 60.5 bits (145), Expect = 3e-07, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 29/105 (27%), Gaps = 10/105 (9%) Query: 742 ILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELY 801 + A P + C K A V R+G G F A +P + TR + Sbjct: 608 FMAQAPAAGLANTETPGTAIHCPKCRAPMVEREGKFGAFFACTRYPACKGTRPLEDHQPE 667 Query: 802 RFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEKDG 846 + P P +VR + S G Sbjct: 668 DG----------TSQKPVPCPHCFSPLVRRKSNKGWFWGCSNFPG 702 >UniRef50_UPI00006CC0A9 DNA topoisomerase family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CC0A9 Length = 1049 Score = 521 bits (1342), Expect = e-146, Method: Composition-based stats. Identities = 153/887 (17%), Positives = 294/887 (33%), Gaps = 123/887 (13%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVK----SSVGHIRDLPTSGSAAKKSADSTSTKTA 56 M + L + E P+ AK I++ LG+ S + + + TS T Sbjct: 1 MKQILNVAEKPSVAKEISRVLGNGSQKTLDSESKYNPVFQFEYKLKQEQVNMLFTSV-TG 59 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHYEVLP----GKEKVVSELKQLAEKADHIYLATDL 112 + N +P + E+L K + L + A + D + L D Sbjct: 60 HLISQKFDDKFKNWKSFNPSVLLDQSSEILKFVESDKISIQRNLIKWARQVDTLILWLDC 119 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 DREGEAIA+ R F+ + + + A N + + A ++R +D Sbjct: 120 DREGEAIAYE-------------RAWFSSLDRLNVTNAINNLRDPRKELSEAVESRMEID 166 Query: 173 RVVGYMVSPLLWKKIARG----------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 +G + + +S G Q + VV+R +I F E+FW + Sbjct: 167 LRIGSAFTVFQTLNLKNNFQSLKDKKEVISYGPCQFPTLGFVVDRYNQILKFQDEKFWYI 226 Query: 223 DASTT-TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEK----ARYSVLEREDKPTT 277 S + + L + + + F + E + V+++ ++ TT Sbjct: 227 QPSYQWKDNNKTLTVDLKWSRGRLFDQAIASVFYLNCTQNEDGEYDPKGIVVKKNERDTT 286 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVN---- 333 P T L + L +K M A++LY++GYI+Y RT++ N Sbjct: 287 KIRPYPLTTVDLTKQGCRILRMASEKIMHTAEQLYQSGYISYPRTETNKYPDTFQNGQLM 346 Query: 334 -MVRGYISDNFGKKYLPE-----SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADA 387 +VR + Y + + + + +AH I P + + ++ + Sbjct: 347 DLVRNQKQSDEWGFYSSNLIDQGNFQRPRAGKQDDKAHPPIHPIKL----ANKNQLKPEE 402 Query: 388 QKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED 447 K+Y+ I R F+A A T + V D G +++ + ++ + D Sbjct: 403 WKVYEFITRHFLASCGKDAVGAKTEVEVKFNDESFNIDGLVVKEKNYLEIWTYEKWND-- 460 Query: 448 RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 I+P + G + ++ + T PP +E+ L+ + K GIG +T I TIQ R Sbjct: 461 SIVPPLQPGQVIIPQKILLQEGKTTPPKPLTESELIDMMNKNGIGTDATMHDHILTIQKR 520 Query: 508 GYVRVENR-RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH 566 GY F +G + ++ L D A+ME + VA + +A++ Sbjct: 521 GYAVKNQHLMFTPTPLGLALCHAYDQLGLTLSKPDLRAKMERLMSDVAEGKTTREAIITQ 580 Query: 567 FFSDFTQQLDKAEKDPEEGGMR---------------PNQMVLTSIDCPTCGRKMGIRTA 611 + E++ + N + +C C + M ++T Sbjct: 581 IMEEMKSIYKTVEQNKQLFIKSVGEQLKEQENSASTLNNSNIQPGSECGKCQKIMELQTN 640 Query: 612 STGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDS 671 L C+ C + ++ N RCP C + Sbjct: 641 DYQRQLVCN--------PCNKSYSIPKNG-------------NLNFRNERCPLCNFQVLE 679 Query: 672 YLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMAC 731 D ++C P+C E + + +K C Sbjct: 680 VTTDKGISYNIC---PSCYNNPPYEQDIENSNANSEDSNFKKTSM----------PCYKC 726 Query: 732 TNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGV--FLAANTFPKS 789 N+ C + + + C ++ +R+ F+ +P Sbjct: 727 INKNCSLSGGLKN-------------ISLYNCPCCNSPIQIRETKKDKKQFIGCTKYPDC 773 Query: 790 RETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 + L +++ + E + + + V+F + Sbjct: 774 DWSV-FLPKDILQIFPTSQEC----QSCKENNRKSLLVEVKFEEGGQ 815 >UniRef50_Q8EVZ3 DNA topoisomerase n=1 Tax=Mycoplasma penetrans RepID=Q8EVZ3_MYCPE Length = 707 Score = 519 bits (1337), Expect = e-145, Method: Composition-based stats. Identities = 229/756 (30%), Positives = 366/756 (48%), Gaps = 76/756 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L+I ESP K KT+ KYLG DY + +++GHIRDL + D+ P Sbjct: 1 MDKLLII-ESPNKIKTLTKYLGKDYEIIATIGHIRDL----NQFGMGFDADFEPKWVIPS 55 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 + N + K+++V +LK+ A KA IY+ATD DREGEAIA Sbjct: 56 VKKNSKNKNEVS----------------KKEIVEKLKKSASKAKEIYIATDPDREGEAIA 99 Query: 121 WHLREVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ EV+ + R+ FNEITKNAI ++ N +++I+ V +Q ARR +DR++G+ + Sbjct: 100 WHVYEVLDAASQKKCKRITFNEITKNAILESLNHKRDIDINWVQSQFARRIIDRLIGFKL 159 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-------- 231 S LL K+ SAGRVQSVA++ + +RE+EI+ FV E +W +D + Sbjct: 160 SKLLQTKLKAD-SAGRVQSVALKFIEDREKEIRNFVAENWWTLDVMLEDNNSLILKSIDP 218 Query: 232 --EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED-KPTTSKPGAPFITST 288 + + L + ++E ++ L ++ V E+ +S P +P+ TST Sbjct: 219 NLKNIKLSEKKFSTSGLDIADEESANNLLNAL-DKKFKVKSIEEPSFYSSYPKSPYKTST 277 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYIS 340 LQQ A +LG+ KK ++AQ LYE I+Y RTDS LS V +I Sbjct: 278 LQQDAINKLGWNSKKITLIAQHLYEGVEVDGNQIALISYPRTDSLRLSDTFVQSAFKFIE 337 Query: 341 DNFGKKYLPE-SPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQF 398 + +GK Y+ + A+ N+Q+AHEAIRP D + + LK+ + D LYQLI+ + Sbjct: 338 ETYGKDYVGKYQVKSSANDANTQDAHEAIRPIDPYLTPQELKNKISKDEFALYQLIYNRT 397 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI--LPAVNKG 456 VA M AK+ T+ + R F G+ K+ + +E+++ L G Sbjct: 398 VASLMAAAKFKKVTIKFDNNNCEFYTFSRECLFLGFKKLYVEDNEDEENKLIDLNNYPVG 457 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516 + +H T+PP R+++A+L+ +LE G+GRPSTY+S+ + +RGY + + Sbjct: 458 KEFKSKVMEVKKHETQPPQRYTQATLIGDLESAGVGRPSTYSSMANIALERGYAVTDKKA 517 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 + +G+IV D+LE+ F +++N DFT +ME LDQ+A+ EWK+ L F F +++ Sbjct: 518 YVMTDIGKIVVDQLEKFFPDIINKDFTKKMEEHLDQIASGNEEWKSWLKKFAPGFDEEVK 577 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG--VFLGCSGYALPPKERCKTTI 634 KA E+ +CP CG+ + + A G F+GCSGY C Sbjct: 578 KAYDTMEKISDE-----KVGRECPKCGKDLLYKRARRGGSKFIGCSGYP-----ECTH-- 625 Query: 635 NLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEI 694 + + CP+CG+ + ++ C + P C+ Sbjct: 626 --------------LEPLEKPEELEISCPECGSKLLKRKSKRQQVFVGCSSWPKCNYIIS 671 Query: 695 EEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMA 730 ++ + + P ++ R K+ Sbjct: 672 DKLFDK-HMKETPDKPLPSKKELEEIRAARLPKWKK 706 Score = 64.4 bits (155), Expect = 2e-08, Method: Composition-based stats. Identities = 24/138 (17%), Positives = 46/138 (33%), Gaps = 18/138 (13%) Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFG--KYMACTN-EECKNTRKILRNGEVAPPK 752 + EC KCG ++ K R G K++ C+ EC + Sbjct: 580 YDTMEKISDEKVGRECPKCGKDLLYKRARRGGSKFIGCSGYPECTHLE-----------P 628 Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGV-FLAANTFPKSRETRA--PLVEELYRFRDR-LP 808 + E+ C + + + R F+ +++PK + + + D+ LP Sbjct: 629 LEKPEELEISCPECGSKLLKRKSKRQQVFVGCSSWPKCNYIISDKLFDKHMKETPDKPLP 688 Query: 809 EKLRYLADAPQQDPEGNK 826 K + P+ K Sbjct: 689 SKKELEEIRAARLPKWKK 706 Score = 53.6 bits (127), Expect = 3e-05, Method: Composition-based stats. Identities = 27/227 (11%), Positives = 61/227 (26%), Gaps = 7/227 (3%) Query: 620 SGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRK 679 + Y + + + K E + + A P ++M + ++ Sbjct: 452 NNYPVGKEFKSKVMEVKKHETQPPQRYTQATLIGDLESAGVGRPSTYSSMANIALERGYA 511 Query: 680 LHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNT 739 + D +I + D + K E ++ + ++ Sbjct: 512 VTDKKAYVMTDIGKIVVDQLEKFFPDIINKDFTKKMEEHLDQIASGNEEWKSWLKKFAPG 571 Query: 740 RKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG--VFLAANTFPKSRETRAPLV 797 ++ C K + + G F+ + +P+ T + Sbjct: 572 FDEEVKKAYDTMEKISDEKVGRECPKCGKDLLYKRARRGGSKFIGCSGYPEC--THLEPL 629 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQYVSSEK 844 E+ PE L + + V S K Y+ S+K Sbjct: 630 EKPEELEISCPECGSKLLKRKSKR---QQVFVGCSSWPKCNYIISDK 673 >UniRef50_D1BLQ5 DNA topoisomerase n=3 Tax=Veillonella RepID=D1BLQ5_VEIPT Length = 773 Score = 519 bits (1337), Expect = e-145, Method: Composition-based stats. Identities = 172/789 (21%), Positives = 281/789 (35%), Gaps = 135/789 (17%) Query: 5 LVIVESPAKAKTINKYLG--------SDY------VVKSSVGHIRDLPTSGSAAKKSADS 50 L I E P+ A+ I+K L + Y VV VGH+ G K Sbjct: 3 LFIAEKPSMAREISKCLPENKNIQKRNGYFIQGDDVVTWVVGHVLHQAEPGDYDDKYIRW 62 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLAT 110 P E V + +K L +KAD I A Sbjct: 63 RPQDLPIVPA-------------------EWKLLVTDSSRQQFEIVKDLIDKADVIVNAG 103 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQAR 168 D DREG+ + + +G + R++ N + + +IR A + + + + AR Sbjct: 104 DPDREGQLLVDEVLYYVG-NTKPVQRILLNALDEKSIRSALDDLRDNKDFHNLYQSALAR 162 Query: 169 RFMDRVVGYMVSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD 223 D ++G +S K L GRV++ + LVV RERE+ AF P +++ V Sbjct: 163 ARADWLIGMNLSRAYTLSERYKGNKVTLPIGRVKTPTLALVVRRERELAAFKPVDYFTVK 222 Query: 224 ASTTTPSGEALALQVTHQN----DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSK 279 P+G A D R +NK + V L+ V++ K Sbjct: 223 VLYNHPNGVFWATWQPTDEQKGLDPDGRLINKAIADSLVEQLQSGPDGVIKAVTKSKKKD 282 Query: 280 PG-APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGY 338 P S+LQ A + + + AQ+LYE TY R+D L + + Sbjct: 283 VQRLPLSLSSLQVLAGKAFSYDPQTVLDTAQKLYEKKLTTYPRSDCEYLPPNQYDDRNAI 342 Query: 339 ISD--NFGKKYL-------PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQK 389 +++ N G + L S A E AH AI P+ V A ++ + + + Sbjct: 343 LNNLQNAGDERLAQWAADADRSIKSRAWNEKKITAHHAIIPTTV---ACNINSLSQEERN 399 Query: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM----------- 438 +Y LI + ++A Y+ T + V A GR++ +GW + Sbjct: 400 IYFLISQAYIAQFYGEHIYEQTKIVVEQCKEEFVANGRVVIEEGWKLLYKRHKSKSTTDN 459 Query: 439 --------------PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVK 484 P +E LPAV K D + + + TKPP+RF+ ++L++ Sbjct: 460 DEPDLTDERGAESDPKKEIIEETDHLPAVKKNDTVLYTDSSVEAKQTKPPSRFTPSTLLQ 519 Query: 485 ELEKR-----------------GIGRPSTYASIISTIQDRGYVRVENRR--FYAEKMGEI 525 +++ GIG +T A+II + RG+++ ++ + G + Sbjct: 520 AMKEIHKFVKNEDLKKQLKAVSGIGTEATRANIIDELISRGFMKTSGKKQVLSPTETGYL 579 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 + D L E EL+ D TA E L ++ E + L +DK D Sbjct: 580 LVDALPE---ELLYPDETAVWEERLALMSEGEDTLDSFLADQIKFLKLLIDKLGFDKVIN 636 Query: 586 GMRPNQMVLTSID--------------------CPTCGRK-MGIRTASTGVFLGCSGYAL 624 + V+ +I CP C + + R G FLGC+ Y Sbjct: 637 SDQMMPNVVRTITSQNRKRPMDSESVDLSSLPVCPKCKKGRLQQRNGKFGAFLGCTNYPT 696 Query: 625 PPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCG 684 CK T + + + E + + +CP+C R +C Sbjct: 697 -----CKHTQPVEGDTSSVEGN----IEVSDEDKQYKCPRCNVGYFVKQEVRGRTNWICS 747 Query: 685 NNPTCDGYE 693 N C Sbjct: 748 NRSQCKTQC 756 Score = 52.8 bits (125), Expect = 5e-05, Method: Composition-based stats. Identities = 15/84 (17%), Positives = 29/84 (34%), Gaps = 6/84 (7%) Query: 763 CEKSD-AYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQD 821 C K R+G G FL +P + T+ P+ + + D + Sbjct: 670 CPKCKKGRLQQRNGKFGAFLGCTNYPTCKHTQ-PVEGDTSSVEGNIEVSD---EDKQYKC 725 Query: 822 PEGN-KTMVRFSRKTKQQYVSSEK 844 P N V+ + + ++ S + Sbjct: 726 PRCNVGYFVKQEVRGRTNWICSNR 749 >UniRef50_Q7Q111 DNA topoisomerase n=3 Tax=Endopterygota RepID=Q7Q111_ANOGA Length = 1025 Score = 519 bits (1336), Expect = e-145, Method: Composition-based stats. Identities = 152/730 (20%), Positives = 268/730 (36%), Gaps = 85/730 (11%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 K L + E AKTI L S I + + TS Sbjct: 30 KYLNVAEKNDAAKTIAGLLSRGSSQRREGYSPYNKIYEFSYNLHGQSIQMIMTSVS-GHL 88 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEV--LPGKEKVVSELKQLAEKADHIYLATDLDREG 116 + + P ++A EK+ L++ + + TD DREG Sbjct: 89 LTHEFLPSFRGWHSCSPEDLFDAPVRKNCPEQYEKIKKTLEREVRGCSALIIWTDCDREG 148 Query: 117 EAIAWHLREVIGGDDA--RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E I + + EV R R F+EIT +I++A + + + +A R +D Sbjct: 149 ENIGYEIIEVCRAVKPQLRVFRAKFSEITAPSIKRAIENLVQPDARQNDAVNVRSELDLR 208 Query: 175 VGYMVSPLLWKKIARG---------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G + ++ + +S G Q + V +R +EI+ F+P+ FW++ + Sbjct: 209 IGAAFTRFQTLRLQKSFPQDISNNLVSYGSCQIPTLGFVAQRYKEIENFIPQTFWKIKLT 268 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLE-KARYSVLEREDKPTTSKPGAPF 284 T L ++ + R +K+ +A + L + V+ KP P Sbjct: 269 HTIDD---LTVEFHWSRN---RLFDKQCCEAYLMLCQTNPTAKVVNVTQKPKNKWRPTPM 322 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV--NMVRGYI--- 339 T L++ S +L K+ M +A++LY G I+Y RT++ + D +V+ + Sbjct: 323 DTVELEKLGSRKLKMNAKQVMTIAEKLYTQGIISYPRTETNMFTGDMKLAPLVQAQVASD 382 Query: 340 -SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 +F +K L N + + S +AH I P+ + ++ D ++Y+LI R F Sbjct: 383 QWGSFAEKVLQWGVN-PRNGKKSDQAHPPIHPTKL------PTNLSGDEWRVYELIARHF 435 Query: 399 VACQMTPAKYDSTTLTVGAGDFR-LKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 +AC A T + V + A G + + +V P R ++ + + G Sbjct: 436 LACVSRDATGSETIVNVVVAEEEEFTASGLCIHERNYLEVYPYDRWNAKE--IHSYQVGH 493 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV-RVENRR 516 EL + T P +EA L+ +EK GIG +T+A I+TI++RGY+ + Sbjct: 494 TFEPTELGLHEGSTTAPNMLTEADLIALMEKHGIGTDATHAEHINTIKERGYIGERDRGF 553 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 +G + + E L + + A +E L V VL + + + Sbjct: 554 LVPGTLGMGLVEGYEMMELRLAHPELRAGLEADLKLVCEGRKNPNDVLAEQIAKYKEVYR 613 Query: 577 KAEKDPEEGGMRP------------------------NQMVLTSIDCPTCGRKMGIRTAS 612 + + + CP CG KM +RT Sbjct: 614 IMSQKARALDRAMGQRLNQTPQEPPPDAGASAATATGSAPMREVCKCPKCGHKMCLRTKR 673 Query: 613 --TGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMD 670 +G +LGC + C+ I +NVL+ C +CG+ Sbjct: 674 DSSGYYLGCVAFP-----ECRNNIWFDDSMREINVLDDT------------CARCGSKKM 716 Query: 671 SYLIDPKRKL 680 + R Sbjct: 717 TVKFRSVRFY 726 >UniRef50_O27661 DNA topoisomerase 1 n=4 Tax=Methanobacteriaceae RepID=TOP1_METTH Length = 718 Score = 519 bits (1336), Expect = e-145, Method: Composition-based stats. Identities = 186/761 (24%), Positives = 329/761 (43%), Gaps = 78/761 (10%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 ++I E P ++ I L D + K G + + + S + Sbjct: 11 VIICEKPKSSEKIAGALFPDAM-KKKHGKVSYWEHVEGDKRVTIVSAVGHLYSLRPRQSN 69 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + W +E+ K + ++ +++ A AD A D D EG I + Sbjct: 70 EEHFFDLE------WAPIHEIDKKKGYVKDYLNVIRKFAAGADRYIHACDYDIEGTLIGF 123 Query: 122 HLREVIGGDD--ARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 + + G++ + SR+ F+ +T+ I++A+ P E++ +V++ AR +D + G + Sbjct: 124 NALKYGCGEEALRKTSRMKFSTLTREEIQRAYKNPIEVDYGQVDSGAARHILDFIFGVNI 183 Query: 180 SPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEA 233 S L K + LSAGRVQ+ + ++VERE+EI+ F P +W + A GE Sbjct: 184 SRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEIRDFKPVPYWIIRAEL----GEG 239 Query: 234 LALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAA 293 + + K + +E + + + + V + + T KP PF TLQ A Sbjct: 240 IIAE-----SKRGKIFKRELVDSILEKCQGSDAEVKDVRVRDTIRKPPVPFDLGTLQSEA 294 Query: 294 STRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD-AVNMVRGYISDN--FGKKY-LP 349 GF KKT +AQ LY GY +Y RT S L + + ++ N FG Sbjct: 295 YRVFGFSPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYEKILKNLAKNPRFGVHIERL 354 Query: 350 ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYD 409 P + + +AH AI P+ + ++ D +K+Y LI +F++ A Sbjct: 355 RGPLKPHEGKKEDDAHPAIHPTGLLP-----SELSKDEKKVYDLIVHRFISVFGEDAILQ 409 Query: 410 STTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 + + + G+ + + GW + P + DE+ P ++ GD+L + ++ + Sbjct: 410 TMKVELEIGEEEFSFSRKRVSKAGWMESYPYTKMEDEE--FPEISGGDSLAVRSVSADER 467 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 TKPPAR++EASL++ELE+RG+G ST A II+ + DR Y+ ++ +GE + D Sbjct: 468 ETKPPARYNEASLIRELERRGLGTKSTRADIIAKLYDRKYIE--GKKIRVSPLGENIIDT 525 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP 589 L ++++ + T Q E L+ + + V+D ++ L E++ + G Sbjct: 526 LTRYCEKIISEELTRQFERELEDIMRGKISKDRVIDEAITEVRSILSDIEENLRDIGKEL 585 Query: 590 NQMVLTS---IDCPTCGRKMGIRTASTGV--FLGCSGYALPPKERCKTTINLVPENEVLN 644 + S +CP CG K+ I+ + F+GCS Y C+T +L VL Sbjct: 586 YRAYQDSRVVGECPACGGKLVIKYSPRNRSTFVGCSSYP-----DCRTVYSLPRGASVLK 640 Query: 645 VLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGY 704 L C KCG M SY R +P C + Sbjct: 641 SL---------------CEKCGLPMISY----GRPRQRACLDPKCG--------KKKSEV 673 Query: 705 DGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILR 744 + + +C +CGS++ + GR+G+++ C +C+ T + Sbjct: 674 EEVVGKCPECGSDLIKRSGRYGEFVGCKGFPKCRFTCSVDE 714 >UniRef50_A1TJM5 DNA topoisomerase n=55 Tax=Proteobacteria RepID=A1TJM5_ACIAC Length = 680 Score = 518 bits (1335), Expect = e-145, Method: Composition-based stats. Identities = 160/698 (22%), Positives = 259/698 (37%), Gaps = 99/698 (14%) Query: 5 LVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 +V+ E P++ K I + LG V +GH+ + + + + Sbjct: 3 VVLCEKPSQGKDIARVLGARQREAGCLAGPGIKVTWGIGHLIEAAPPEAYGEHFQRWSLE 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 P+ + + V +++L +A + +ATD D Sbjct: 63 TLPIVPQ-------------------QWRWVVKADTASQFKVVQRLLAQASELIIATDAD 103 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRFM 171 REGE IA L E G R+ + + +IR+A + + AR Sbjct: 104 REGEMIARELIEYCG-YRGPIQRLWLSALNDASIRKALGALRASHETLPLYHCALARSHA 162 Query: 172 DRVVGYMVSPLLWKKIAR-----GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D +VG ++ L + LS GRVQ+ ++LV +R+REI AFVP FW ++ S Sbjct: 163 DWLVGINLTRLFTLLGRKAGFDGVLSVGRVQTPTLKLVADRDREIAAFVPVPFWSIEVSL 222 Query: 227 TTPSGEALALQVTH--QNDKPFRPVNKEQTQAAVSLLE-KARYSVLEREDKPTTSKPGAP 283 + + A V D R + + Q A + + V + + P P Sbjct: 223 SAGAQAFSAHWVPPATVTDAAGRCLQQSAAQHAAAAVRTAGHAQVTGIDTERVQEGPPLP 282 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDN 342 F STLQ+ S RLG V++T+ +AQ LYE TY RTD+ L ++ + V I Sbjct: 283 FDLSTLQEVCSRRLGLDVQETLDIAQALYETHKATTYPRTDAGYLPENMLTEVPTVIRSL 342 Query: 343 FGKKY--------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 L A AH AI P+ + L M +Y+LI Sbjct: 343 LKTDPALQPLMQRLDLGQRSRAWNATKIAAHHAIIPT---LEPADLSKMSEKELAVYRLI 399 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM------------PALR 442 ++A + YD T + + G L+A G+ + GW P Sbjct: 400 RAHYLAQFLPHYAYDRTMVRLACGGQALQASGKQVVDAGWKAAFAAPSIPGAGAETPEAE 459 Query: 443 KGDE---DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR---------- 489 E D+ LP +++G A + L +TK P +++ LVK ++ Sbjct: 460 TDSEAPRDQALPTLHEGMACEVRSLDLKSLYTKSPPPYTQGELVKAMKTVAKLVTDPRLK 519 Query: 490 -------GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDF 542 GIG +T A+IIS + RG++ + R A K + D + + + Sbjct: 520 QTLRDTTGIGTEATRANIISGLLARGFLVRKGRVVRASKTAMTLIDAVPAA---IADPGT 576 Query: 543 TAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTC 602 TA E +L + + + + +Q +++ V CP C Sbjct: 577 TAIWEQALHMIEARTMDLDTFVSKQAAWVSQLVEQ------HREATLAIRVPAGPPCPLC 630 Query: 603 GRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEN 640 G RT TG F CS Y CK T+ + Sbjct: 631 GAATRKRTGKTGAFWSCSRYP-----DCKGTVAIDSAE 663 Score = 56.3 bits (134), Expect = 6e-06, Method: Composition-based stats. Identities = 15/55 (27%), Positives = 20/55 (36%), Gaps = 4/55 (7%) Query: 762 PCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYR----FRDRLPEKLR 812 PC A R G G F + + +P + T A E R + R KL Sbjct: 626 PCPLCGAATRKRTGKTGAFWSCSRYPDCKGTVAIDSAEAGRRNGPRKPRAARKLH 680 >UniRef50_B6ADG7 DNA topoisomerase n=1 Tax=Cryptosporidium muris RN66 RepID=B6ADG7_9CRYT Length = 857 Score = 518 bits (1334), Expect = e-145, Method: Composition-based stats. Identities = 161/852 (18%), Positives = 292/852 (34%), Gaps = 67/852 (7%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKS-SVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 L++ E P+ A+T+ K L + + + + T+ K++ ++ + + Sbjct: 29 PTVLMVAEKPSIAETVAKVLSNGNLNTRQCKTPVHEY-TAYFQHKRALFKVTSVSGHVFE 87 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 D N +DP ++ K+++ L + A+ D + L D DREGE I Sbjct: 88 TDFPSKYSNWESIDPVDLFDLPTVKNESSSKMIAHLLREAKNCDFLVLWLDCDREGENIC 147 Query: 121 WHLREVIGGDDAR-------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 + + V+ A+ R F+ + + +A N N D +A R+ +D Sbjct: 148 FEVISVVKDVMAKGRNESLWIFRARFSSVAPKDVIEAMNNLKSPNRDEADAVDVRQELDL 207 Query: 174 VVGYMVSPLLWKKIARG--------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G S + LS G Q+ + VV+R +I F PE+F+ ++ + Sbjct: 208 KIGVAFSRFQTTYLKTKYGDFNNSILSYGPCQTPTLFFVVQRRDKILGFSPEKFYYLNVT 267 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 + L T + K F + + V+ V++ + K P Sbjct: 268 IEYKD---IILSPTWERKKIFDLQSIQCLYNTVNSTYPIIAKVIDIKKKADRISRPLPLN 324 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-VNMVRGY-----I 339 T + + AS LG + M +A++LY +G+ITY RT++T + + Sbjct: 325 TVQMLKLASNILGISPFQAMNIAEKLYLSGFITYPRTETTKYPKSFDTKEAASIHKDHPL 384 Query: 340 SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFV 399 + L + H I P + D+ D +LY+LI R F+ Sbjct: 385 WGQYTCDILARNYTNPRQDGIDVGDHPPIVPIRSVIS----NDLAGDNWRLYELITRHFL 440 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 A K+ + + + +GR + G++ + + +P ++ G L Sbjct: 441 ATISPDIKFTNEFVIFDINGEKFTLQGRRINEYGFSIIYKSKSINS--ISIPQLDLGMKL 498 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV-RVENRRFY 518 L + TKPP SE +L+ +EK GIG ++ I + +R YV ++ R+ Sbjct: 499 NLKSIEICNGETKPPPLLSEGNLLSLMEKNGIGTDASMPVHIQKLIERKYVNIIDGRKLE 558 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDH----FFSDFTQQ 574 ++G + EL+ ++ME + ++ +A VL H F F Sbjct: 559 PTRLGNALIHGYMNIDIELVYPMIRSEMERYISLISQGKANAGNVLKHTLAIFKLKFLFF 618 Query: 575 LDKAEKDPEEGGMRPNQMVLTSIDCPTCG---RKMGIRTASTGVFLGCS----GYALPPK 627 + + + + CG R M + + L CS LP Sbjct: 619 VKNITSFESLFQLSFTNLSSSGTRLSKCGQCKRYMTYISNTNPPKLYCSFCEINLKLPSG 678 Query: 628 ERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNP 687 K L + +L T + CP+C C +P Sbjct: 679 GSLKLYKELKCPLDDYELLVFNSLRTK--KNMILCPRCYNDPPFDSAIQNILCKECP-HP 735 Query: 688 TCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGE 747 TC P+ +C K G + C+N C K Sbjct: 736 TCPHSYNSSFIM-----YCPVEKC-KDGVLTLDLSSAPNWRIDCSN--CNFVLKFREK-- 785 Query: 748 VAPPKEDPVPLPELPCEKSDAYFVLR--DGAAGVFLAANTFPKSRETRAPLVE-ELYRFR 804 V C A +L + + P E L+E E Sbjct: 786 ----HCHKVSTTNDYCNNCGARILLINLNSPKESIIGC---PICLERINELIEAEENSVS 838 Query: 805 DRLPEKLRYLAD 816 R+ + ++ Sbjct: 839 RRISIRPKFRGS 850 >UniRef50_Q5ZHE3 DNA topoisimerase n=9 Tax=root RepID=Q5ZHE3_9BACT Length = 737 Score = 518 bits (1333), Expect = e-145, Method: Composition-based stats. Identities = 153/756 (20%), Positives = 250/756 (33%), Gaps = 108/756 (14%) Query: 5 LVIVESPAKAKTINKYLGSDYV-----------VKSSVGHIRDLPTSGSAAKKSADSTST 53 LVI E P AK I + LG V GH+ L ++ A+ Sbjct: 6 LVIAEKPELAKAIVEGLGGGSRKDGYYECGSDRVTWCYGHMLALLDPEDYDERYANWNMA 65 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 W G + + L ++A + A D D Sbjct: 66 DLPI-----------------VHIPWRKKPSGDAGAKAQFKTILSLLKQAKSVVHAGDPD 108 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQARRFM 171 EG+ + + E R++ N+ +R+ + A +AR Sbjct: 109 DEGQLLVDEILEYANCR-LPVQRLLINDNNVKIVRRQLAAMRDNREFAGLSAAAEARSVG 167 Query: 172 DRVVGYMVSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D++ G+ ++ L K LS GRVQ+ + LVV R RE A ++ V+ Sbjct: 168 DQLYGFNITRLYTLAARAKGYQGLLSVGRVQTPILGLVVRRCRENAAHQKTYYYLVNGQF 227 Query: 227 TTPSGEA---LALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 + + D+ R NKE + + + ++ K + P Sbjct: 228 EVEGIQFPARYQVADGDPVDEKGRLSNKEHAEGIAAAVSGQPARIVSVTTKAKEAAAPLP 287 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDN 342 + LQ AS + GF + + Q L E ITY R+D LS++ G ++ Sbjct: 288 YNLLKLQMDASRKFGFKPDQVKDITQALREKHKLITYNRSDCEYLSEEQHGDAPGVLAAI 347 Query: 343 --------FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 + + A + AH AI P++ L + QK+Y LI Sbjct: 348 AQTAPMLAAAAQRANPTIKSRAFNSSKVSAHHAIIPTE---STADLSKLTDAEQKIYLLI 404 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDE-------- 446 R +VA YD T + GD R R + GW + ++ Sbjct: 405 ARAYVAQFWPKHLYDQTDVLAQVGDHRFGVRSNVTTSPGWKILYKNDAGNEDLEGNADDI 464 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-------------------- 486 ++ L + G A T + Q TKP ++ SL+ +L Sbjct: 465 EQDLRKLRDGQAGTCTDAKAEQQETKPQPLYTMESLLSDLTRVAKYIRDDRLRKILIEKD 524 Query: 487 -----EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYD 541 E GIG P+T SII+T+ +RGY+ + + + GE + D L + R D Sbjct: 525 KGKQGEHGGIGTPATRDSIIATLFERGYLVEKGKHIVSTPTGEELYDALPDTARF---PD 581 Query: 542 FTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPT 601 TA + E + + ++ ++ M + + CP+ Sbjct: 582 MTALWHEQQKAIQAGERDTLSFVNELMEYIGAEVANI-------KDNGLNMKIDTHPCPS 634 Query: 602 CGRKM--GIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAK 659 CG+ + + F GC+G+A K C E V E Sbjct: 635 CGKPLRRLKKKDKNEYFWGCTGFADGCKFACDDKGGKPVPREAPKVSE-----------L 683 Query: 660 RRCPKCGTAMDSYLIDPKRKL-HVCGNNPTCDGYEI 694 +C CG + + C N PTC Sbjct: 684 HKCMACGHGLSRRPGKKRGMFWWGCSNFPTCKQTYP 719 Score = 74.8 bits (182), Expect = 2e-11, Method: Composition-based stats. Identities = 16/101 (15%), Positives = 25/101 (24%), Gaps = 4/101 (3%) Query: 696 EGEFRIKGYDGPIVECEKCGSEM--HLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKE 753 + C CG + K + + CT G P+E Sbjct: 617 NIKDNGLNMKIDTHPCPSCGKPLRRLKKKDKNEYFWGCTGFADGCKFACDDKGGKPVPRE 676 Query: 754 DPVPLPELPCEKSDAYFVLRDGAAG--VFLAANTFPKSRET 792 P C R G + + FP ++T Sbjct: 677 APKVSELHKCMACGHGLSRRPGKKRGMFWWGCSNFPTCKQT 717 >UniRef50_B1AJN1 DNA topoisomerase I n=15 Tax=Ureaplasma RepID=B1AJN1_UREP2 Length = 681 Score = 518 bits (1333), Expect = e-145, Method: Composition-based stats. Identities = 209/727 (28%), Positives = 345/727 (47%), Gaps = 76/727 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L++VESP K K+I YLG Y V ++ GH+R+L K+ D K Sbjct: 5 MQKDLIVVESPNKIKSIQSYLGDSYNVIATCGHLRELAKKSGYDPKTYDLKWEIIKTTNK 64 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 K K++ + + LA+K+++IYLATD DREGEAI+ Sbjct: 65 KL-------------------------SKKQQIKTIIDLAKKSNNIYLATDPDREGEAIS 99 Query: 121 WHLREVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMV 179 WH+ +++ D R R+ FNEIT+ AI ++ ++ +++ + V++Q ARR +DRV+GY + Sbjct: 100 WHVYDLLPKKDKERVKRITFNEITQKAILKSIDEKHDIDFNLVDSQFARRILDRVIGYKL 159 Query: 180 SPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ-- 237 S L+ K + GLSAGRVQS+A+ VVERE E ++FV EE+++++ +L Sbjct: 160 SGLVKKNLH-GLSAGRVQSIALLFVVERELERRSFVKEEWYQIEGIIEKNIFVSLRKIPY 218 Query: 238 ------VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERED-KPTTSKPGAPFITSTLQ 290 +D + ++K+ Q + L + V +D K T P T L Sbjct: 219 DVELYNQKDNSDSDLKFLHKKDAQRVIDDLSDI-FKVYSIDDLKITKGDVQLPLTTDKLL 277 Query: 291 QAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYISDN 342 Q AS G+ KT ++AQ+++E ITY RTDS LS D + +I +N Sbjct: 278 QIASNNFGWSANKTTLIAQQMFEGLEINNQQLALITYPRTDSERLSDDFLQEANAFIENN 337 Query: 343 FGKKYLPESPNQYASKE--NSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFV 399 FGK+YL N+ +++ N Q+AHEAIRP D+N+ E +KD + D KLY L+W + + Sbjct: 338 FGKEYLENFKNKKINRKEVNIQDAHEAIRPVDINLKPEEIKDYVSLDIYKLYNLVWNKTL 397 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPA-VNKGDA 458 + M ++ + +++ + +R G+ + ++ DE P +N GD Sbjct: 398 SALMKVPTFNKQVIRFINNEYKFYTAYKTIRTLGYWILDFYKKQRDELEFQPPIINVGDE 457 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFY 518 ++ Q T PP ++EASL+ L+ G+GRPSTYA++ + RGY+ + + Sbjct: 458 FKKEKIDLIQKETTPPPYYTEASLIAALKNAGVGRPSTYATMATIGTTRGYINKDKSKLI 517 Query: 519 AEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA 578 ++G V L+E F ++++ FT++ME LD +AN + WK ++ F F +++ +A Sbjct: 518 PTELGIKVIQELKEAFPKVISIKFTSEMEERLDVIANGKLFWKDLVSTFIPIFEEEVKQA 577 Query: 579 EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAS-TGVFLGCSGYALPPKERCKTTINLV 637 E+ + CP C + I+ + F+ CS + C+ T +L Sbjct: 578 YTKIEKVPDEKINRL-----CPICAHDLLIKRSRMNTRFIACSNFPT-----CRFTESL- 626 Query: 638 PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEG 697 CP C ++ + C P C+ + Sbjct: 627 ---------------EKPEILNELCPNCSKSLVKRKNRKNKYFIGCTGYPECNFIRNLDE 671 Query: 698 EFRIKGY 704 K Sbjct: 672 SNNDKND 678 Score = 61.3 bits (147), Expect = 2e-07, Method: Composition-based stats. Identities = 14/110 (12%), Positives = 30/110 (27%), Gaps = 14/110 (12%) Query: 700 RIKGYDGPIVECEKCGSEMHLKMGR-FGKYMACTN-EECKNTRKILRNGEVAPPKEDPVP 757 + C C ++ +K R +++AC+N C+ T + + Sbjct: 582 EKVPDEKINRLCPICAHDLLIKRSRMNTRFIACSNFPTCRFTESLEK-----------PE 630 Query: 758 LPELPCEKSDAYFVLRDGAAGVFL-AANTFPKSRETRAPLVEELYRFRDR 806 + C V R + +P+ R + Sbjct: 631 ILNELCPNCSKSLVKRKNRKNKYFIGCTGYPECNFIRNLDESNNDKNDFN 680 Score = 58.2 bits (139), Expect = 1e-06, Method: Composition-based stats. Identities = 19/119 (15%), Positives = 36/119 (30%), Gaps = 8/119 (6%) Query: 633 TINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGY 692 + + E + + + + R CP C + + C N PTC Sbjct: 564 STFIPIFEEEVKQAYTKIEKVPDEKINRLCPICAHDLLIKRSRMNTRFIACSNFPTCRF- 622 Query: 693 EIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGK-YMACTN-EECKNTRKILRNGEVA 749 ++ + C C + + R K ++ CT EC R + + Sbjct: 623 -----TESLEKPEILNELCPNCSKSLVKRKNRKNKYFIGCTGYPECNFIRNLDESNNDK 676 Score = 45.9 bits (107), Expect = 0.007, Method: Composition-based stats. Identities = 11/86 (12%), Positives = 25/86 (29%), Gaps = 3/86 (3%) Query: 739 TRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGA-AGVFLAANTFPKSRETRAPLV 797 + ++ P C +++ F+A + FP R T + Sbjct: 569 IFEEEVKQAYTKIEKVPDEKINRLCPICAHDLLIKRSRMNTRFIACSNFPTCRFTESLEK 628 Query: 798 EELYRFRDRLPEKLRYLADAPQQDPE 823 E+ + P + L + + Sbjct: 629 PEI--LNELCPNCSKSLVKRKNRKNK 652 >UniRef50_Q5WAX6 DNA topoisomerase 3 n=137 Tax=Bacteria RepID=TOP3_BACSK Length = 729 Score = 517 bits (1332), Expect = e-145, Method: Composition-based stats. Identities = 154/754 (20%), Positives = 268/754 (35%), Gaps = 103/754 (13%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M K V+ E P+ A+ I + LG + Y++ ++GH+ K+ Sbjct: 1 MKKKAVLAEKPSVARDIARVLGCNQKGNGYLEGNGYIITWALGHLVTHADPEHYGKQYKT 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIY 107 + PK V+ K +K + + D + Sbjct: 61 WKLEELPMLPK-------------------RLELVVIKQTAKQFHAVKHVLNRQDVGEVV 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQ 165 +ATD REGE +A + E R+ + +T AI+ F + + A Sbjct: 102 IATDAGREGELVARWILEKAH-VKKPVKRLWISSVTDKAIKDGFKQLKDGKRYETLYAAA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D VG + L K LS GRVQ+ + ++ +RE I+ FVP+ + + Sbjct: 161 AARAEADWYVGINGTRALTTKHNAQLSCGRVQTPTLAILADREEAIRKFVPKPYHTISVE 220 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 T + + + K R + ++ + L+++ + K + P + Sbjct: 221 TKDG----VTFRWADRRSKEERIFDDKRAKTLQEKLQQSAIVIDSVNAKTKRTPPPPLYD 276 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYI----S 340 + LQ+ A+ R G+ K+T+ QRLYE +TY RTDS LS D V ++ + Sbjct: 277 LTELQREANKRFGYSAKETLAALQRLYEQHKAVTYPRTDSRYLSSDLVETLKERLHAVDV 336 Query: 341 DNFGKKYLPESP------NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 F K + + H A+ P++ +S M KLY LI Sbjct: 337 QPFRKMVANAKKQGLANAKRQMVNDAKVSDHHALIPTE---QPQSASAMSDKEAKLYHLI 393 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVN 454 R+F+A P++ + T++ A L+A+G L GW R+LPA++ Sbjct: 394 VRRFLANFFPPSESELTSVEATANGELLRAKGERLVSAGWRGQETGEEDEALARLLPAMS 453 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELEK-------------------RGIGRPS 495 KGD + + Q T PP RF+E +L+ +EK GIG + Sbjct: 454 KGDKKAVKWVGMTQGKTSPPPRFNEGTLLAAMEKPAQHMEAKDETIKKTLAQAGGIGTVA 513 Query: 496 TYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN 555 T A II + Y+ + + Y G+ + + + EL + TA+ E L+++ Sbjct: 514 TRADIIEKLFSSFYIEKKGKDLYITSKGKQLLELVPA---ELKSPALTAEWEQRLEKIVQ 570 Query: 556 HEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV 615 + + + + + + + D T CP CG+ + G Sbjct: 571 GKEQKQMFIAEMKEYAKAVVAQVKAD----TATFRHDNKTGEKCPECGKFLLEVNGKKGK 626 Query: 616 FLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLID 675 C C N+ A+ RCPKC ++ Sbjct: 627 MRVC------QDRECGYRKNI------------------AMTTNARCPKCKKKLELRGEG 662 Query: 676 PKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIV 709 + + + + Sbjct: 663 EGQVFACVCGHREKKAQFEQRRKQNKHKNVSKRE 696 Score = 50.5 bits (119), Expect = 3e-04, Method: Composition-based stats. Identities = 15/83 (18%), Positives = 25/83 (30%), Gaps = 13/83 (15%) Query: 701 IKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPE 760 + + +C +CG + G+ GK C + EC +++ Sbjct: 600 FRHDNKTGEKCPECGKFLLEVNGKKGKMRVCQDRECGY-------------RKNIAMTTN 646 Query: 761 LPCEKSDAYFVLRDGAAGVFLAA 783 C K LR G A Sbjct: 647 ARCPKCKKKLELRGEGEGQVFAC 669 >UniRef50_B1X1Z5 DNA topoisomerase n=3 Tax=Chroococcales RepID=B1X1Z5_CYAA5 Length = 719 Score = 517 bits (1332), Expect = e-145, Method: Composition-based stats. Identities = 216/734 (29%), Positives = 346/734 (47%), Gaps = 65/734 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K ++++E+P K K + K+LG+D+ V ++ GHIR+ SG+ + Sbjct: 16 MAKNVLVIEAPGKRKKLEKFLGADWTVIATGGHIREFDKSGNHNLGFELTPKGTVI---- 71 Query: 61 KDERGALVNRMGVDPWHNWEAHYEV-LPGKEKVVSELKQLAEK--ADHIYLATDLDREGE 117 + +KV+ +L+ A++ ++ I++ATD DREGE Sbjct: 72 --------------------PKFVPRSERSKKVIRQLQMTAKRTNSERIFIATDPDREGE 111 Query: 118 AIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGY 177 I WH +V+G + R+V++EI++ A+R+A P L+ + V + R +D+++GY Sbjct: 112 CIGWHAAQVMGIKNP--QRIVYSEISEKAVRRAIANPRFLDTNLVASALGRSTLDKLIGY 169 Query: 178 MVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQ 237 SPLLW + S GRVQ+ + L+ ERE I+ F PE ++ V + A + Sbjct: 170 TGSPLLWDYVEGAKSMGRVQTPVLTLICEREETIQNFKPETYYSVWSLYKEGLKAFYAGE 229 Query: 238 VTHQND-----------------KPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 ++ + R ++ + V++ ++V+ E K + P Sbjct: 230 SNDNSEDSEEERDDSQTPKETQKESLRVTSEAEANRLVAIARNNSHNVVSLETKKSKKSP 289 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS 340 APF TS LQQAA RL F +TM +AQ+LYEAG ITY RTDST +S D ++R Y+ Sbjct: 290 PAPFTTSNLQQAAGARLKFSPDQTMKLAQKLYEAGVITYHRTDSTVISGDFCKVIRQYLK 349 Query: 341 DNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESL-KDMEADAQKLYQLIWRQFV 399 N + LP+S ++ +N+QEAHEAIRP D+ + ++ A KLYQLIW + V Sbjct: 350 AN-DPENLPKSVIKHRQSKNAQEAHEAIRPVDLAKTETDIASELGDAAGKLYQLIWFRTV 408 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 A Q PA+ D TT+T + KA+G+++ F G+ + L E LP+V + Sbjct: 409 ASQCKPAELDKTTITTQSDTVFWKAKGQVVTFAGYLRYWRDLGADSE---LPSVENHQVV 465 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 TL + + TKPP+RF+EA +VK EK+GIGRPST++ I T++DR YV VE R Sbjct: 466 TLEDAQAEKKQTKPPSRFTEAQMVKVREKKGIGRPSTFSPTIQTLKDRNYVAVEKRMLKP 525 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF----FSDFTQQL 575 ++G V + E+ EL +FTAQME+ LD +A + +W+ + F + ++ Sbjct: 526 TQVGLKVYHFVREHLTELGTVEFTAQMESHLDAIAKGDEKWQPYVCQFHFDHWQPTLIKI 585 Query: 576 DKAEKDP--EEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTT 633 + P + + + CP C M + + P +C+ Sbjct: 586 AQTLGKPAVKSFNGNGKSLEKSRTKCPKCNVAMSKVPSKSKKL------HRPYFLKCEDC 639 Query: 634 INLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA--MDSYLIDPKRKLHVCGNNPTCDG 691 ++ N+ E ++ K CPKC + Y K CD Sbjct: 640 ETVMFYNKERKQWESPGTKSPTQETKASCPKCQKPLHLREYRSKKDGKQKKLLKCLDCDD 699 Query: 692 YEIEEGEFRIKGYD 705 E Sbjct: 700 VVFFESRGCFWSKQ 713 >UniRef50_C4V616 DNA topoisomerase n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V616_9FIRM Length = 711 Score = 517 bits (1331), Expect = e-145, Method: Composition-based stats. Identities = 162/686 (23%), Positives = 254/686 (37%), Gaps = 98/686 (14%) Query: 5 LVIVESPAKAKTINKYL------GSDYV------VKSSVGHIRDLPTSGSAAKKSADSTS 52 L I E P+ + + L GS ++ V GH+ + Sbjct: 3 LYIAEKPSVGRALATCLPAPHRKGSGWIETGGGVVTWLFGHVLRQAEPEEYDPALKRWRA 62 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 PK E H V + + +K L +AD I A D Sbjct: 63 EDLPILPK-------------------EWHLVVNESAAQQFAVVKGLIARADEIVHAGDP 103 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQARRF 170 DREG+ + + + +G + R++ N + +I A N + + + AR Sbjct: 104 DREGQLLVDEVLDFLG-NTKPVRRILINALDDKSIHDALNDLRDNGDFLPLKLSALARAR 162 Query: 171 MDRVVGYMVSPLLWKKIAR------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 D ++G +S R L GRV++ + LVV REREI+ F P ++ VDA Sbjct: 163 ADWLIGMNLSRAYTLAARRAGHARLVLPIGRVKTPTLALVVRREREIEHFTPATYYLVDA 222 Query: 225 STTTPSGEALALQVTHQNDK-----PFRPVNKEQTQAAVSLLEKARY--SVLEREDKPTT 277 T +GE + ++ R V++ AA + + V + E K Sbjct: 223 LFRTEAGEPFRARWKPSEERTPLDPEGRLVDRAAADAAAASFGEPPADGVVTKYERKKKE 282 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 P PF S LQ A R G+ ++ + AQ+LYE +Y R+D+ L Sbjct: 283 EPPPLPFSLSALQVLAGKRYGYEPQQVLDTAQKLYEEKLTSYPRSDAEYLPVSQHKDAAK 342 Query: 338 YISDNFGKKYLP---------ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ 388 + + P + A + AH AI P+ V +L + A + Sbjct: 343 ILGNLAALSDTPLAAWAQAADSAKKSRAWNDAKISAHHAIIPTTV---PVNLARLTAVER 399 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM--------PA 440 +Y+LI R ++A YD T V ARGR R GW + A Sbjct: 400 NIYELIARAYIAQFCPNYVYDQTKAEVTHHGETFTARGRTERTAGWRTMYRAGKNESEDA 459 Query: 441 LRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR----------- 489 ++ +E +LP + KGDA V + TKPPARF+ A+L++ +++ Sbjct: 460 EKEDEESTVLPPMKKGDAAAFVSAETKERQTKPPARFTPATLLQGMKEIHKYVKDEAAKK 519 Query: 490 ------GIGRPSTYASIISTIQDRGYVRV--ENRRFYAEKMGEIVTDRLEENFRELMNYD 541 GIG +T ASII + R ++ + + ++ D L + + D Sbjct: 520 MLRDVSGIGTEATRASIIEDLIRRKFLHAAGKKKVLTPTAEAYLLIDALPDT---MTYPD 576 Query: 542 FTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPT 601 TA E+ L +A+ + L + D A GG I CP Sbjct: 577 ATAIWEDQLHAMADGVGTPEEFLAGQAAFARDLCDAARTAQITGG--------EGIPCPA 628 Query: 602 CGRK-MGIRTASTGVFLGCSGYALPP 626 CGR M R G F GCS + Sbjct: 629 CGRGVMLKRKGKHGDFWGCSAFPQCR 654 Score = 50.5 bits (119), Expect = 3e-04, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 17/50 (34%), Gaps = 1/50 (2%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSD-AYFVLRDGAAGVFLAANTFPKSRET 792 R+ A +PC + R G G F + FP+ R T Sbjct: 607 RDLCDAARTAQITGGEGIPCPACGRGVMLKRKGKHGDFWGCSAFPQCRMT 656 >UniRef50_C0YH06 DNA topoisomerase n=4 Tax=Bacteroidetes RepID=C0YH06_9FLAO Length = 695 Score = 516 bits (1330), Expect = e-144, Method: Composition-based stats. Identities = 130/656 (19%), Positives = 247/656 (37%), Gaps = 75/656 (11%) Query: 6 VIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTK 54 +I E P+ A+ I + LG + Y V ++GH+ L + S Sbjct: 4 IIAEKPSVAREIAQLLGAHEKKDGYLSGNGYCVTWALGHLISLGMPEDYGIRGFKKASLP 63 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 P L G YE P K ++ ++Q+ ++ I +ATD R Sbjct: 64 IFPNPFILTPKKLKKAKG----------YEPDPSALKQLNTIQQVIKQCSSIIVATDAGR 113 Query: 115 EGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRFMD 172 EGE I ++ + + + R+ + +T+ AI+ F PG+ A +AR D Sbjct: 114 EGELIFRYIYHYLQC-NKPFERLWISSLTEKAIQDGFKNLQPGDAFDGLYQAAKARSEAD 172 Query: 173 RVVGYMVSPLLWKKIAR-GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 +VG + L + S GRVQ+ + L+ +R + + F ++++++ S Sbjct: 173 WLVGINATQALTIGGNQDVYSLGRVQTPTLALICQRFLQHQNFTKQKYFQIQLSHRKEYT 232 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + +L + +K EQ Q + + R V + K + F + LQ+ Sbjct: 233 DFTSLSLLQWEEKK----QAEQIQKIIER--EGRAIVEDVSVKTVQEQSPLLFDLTELQK 286 Query: 292 AASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS--------DNF 343 A+ +LG + + AQ LYE +ITY RT S + +D + + Sbjct: 287 EANRKLGLSADEVLQTAQSLYEKQFITYPRTGSKYIPEDLWTDIPELVRILNQTEPFKAA 346 Query: 344 GKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQM 403 + N+ + H + + ++ + A + +Y +I + + Sbjct: 347 ITHLKFGNFNKRIVNDVKVTDHHGLLITT-----KTPSALSATEKAIYDMIAYRLLESLS 401 Query: 404 TPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR-------ILPAVNKG 456 T + + + + +G + GW + L + LP G Sbjct: 402 HTCTKQVTQIQIKVHHYEFQIKGSKILNKGWRAIKGILSDNENSNNANEDLTELPEFKIG 461 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRPSTYASI 500 D L + + + T+PP ++EA L+ +E GIG P+T ASI Sbjct: 462 DELKISKTELLEKTTQPPKLYTEADLLSVMENAGRSIENKEDQKALSNIGIGTPATRASI 521 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 I T+ R Y+ +++ + G V + +++ +++ N TA+ E +LD++ E Sbjct: 522 IETLLSRNYIVRKSKTLHPTDKGLQVYNLVKD--KKIANVQMTAEWEIALDKIEKGELNK 579 Query: 561 KAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVF 616 ++ + AE E + Q + + CP C + I Sbjct: 580 TQFMNDIQAY------TAEITSELLSLHIPQENIPQLKCPKCQQHNLIIKDKIVKC 629 >UniRef50_A8MIQ9 DNA topoisomerase n=2 Tax=Clostridiaceae RepID=A8MIQ9_ALKOO Length = 716 Score = 516 bits (1330), Expect = e-144, Method: Composition-based stats. Identities = 157/732 (21%), Positives = 275/732 (37%), Gaps = 88/732 (12%) Query: 3 KALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K LVI E P+ AK I K L GSDY++ ++GH+ L + Sbjct: 2 KRLVIAEKPSVAKDIAKVLNCKEKREGYIEGSDYIITWAIGHLVILCDPEEYDIRYKKW- 60 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIYLA 109 P + + P K +K L + D I A Sbjct: 61 ------------------DFNTLPIIPDKIKLKPNPKTYKQYQIVKALMLSSQIDEIICA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQA 167 TD REGE I ++ E+ + R+ + +T IR F + + + Sbjct: 103 TDAGREGELIFRYIYELAKCR-KPFQRLWISSLTDEGIRTGFEHLKDGKAYDALYYSAKC 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D +VG S + L GRVQ+ ++++V+R+ EI FVP+++WEV A Sbjct: 162 RSESDWLVGINGSRAYSIQYGSLLPIGRVQTPTLKIIVDRDLEIDDFVPKDYWEVKADF- 220 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 G + + + ++ + + ++ + + + V + + K KP + + Sbjct: 221 ---GNYSGIWIDLEKNES-KIDSIQKAEDIKNKVLLKEGLVTDFQKKKVVKKPPFLYDLT 276 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 LQ+ ++ + G+ ++T+ +AQ LYE ITY RTDS L++D + ++ I+ + Sbjct: 277 ELQRDSNKKFGYTAQRTLDIAQSLYEKRKAITYPRTDSRFLTKDIIPKLKSLINKIGLEG 336 Query: 347 Y---------LPESP-NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWR 396 Y L + P N + H AI P++ + L + + LY LI R Sbjct: 337 YKEFTSILEKLEKLPVNPRIINDRKVTDHHAIIPTEKKI---DLNKFSEEEKNLYDLIAR 393 Query: 397 QFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKG 456 +F+A +Y S + K+ + GW + ++ L + KG Sbjct: 394 RFLAVFYPDYEYFSIVMITHVAGEDFKSNEQQTIHLGWKLLYSDKEVETKESTLIHIKKG 453 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRPSTYASI 500 + TL Q TKPPAR++EA L+ +E GIG P+T ASI Sbjct: 454 SSSTLKSAEIEQKQTKPPARYNEALLLDSMENAGKFIEDEELKEQLKSSGIGTPATRASI 513 Query: 501 ISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEW 560 I I GYV + + + + G + +EL + + T + E +LD++A Sbjct: 514 IERIISVGYVERKGKNLISTEKGRKLIQI---TSQELSSPELTGKWEKALDKIAKGNMNP 570 Query: 561 KAVLDHFFSDFTQQLDKAEK---------DPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 + ++ ++ +K + G + + + C + Sbjct: 571 QRFMEGIGRFTKFIIEDVQKNTKNVVFEGYSKNRGKKSSGTSSYNSPIGICPACKVGKVL 630 Query: 612 STGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDS 671 CS Y K+ CK I + + L + M S Sbjct: 631 EGPKNFYCSEY----KQGCKFGIFKEDILMKKFKKKMTKTMVSKLITNQV--VTVKGMVS 684 Query: 672 YLIDPKRKLHVC 683 + K ++C Sbjct: 685 PKTNGKFDGNIC 696 >UniRef50_UPI0001C41D8C DNA topoisomerase I TopA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41D8C Length = 741 Score = 516 bits (1329), Expect = e-144, Method: Composition-based stats. Identities = 188/775 (24%), Positives = 333/775 (42%), Gaps = 69/775 (8%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 ++I E P A+ I K L + K I + K + S R Sbjct: 4 VIISEKPKSAEKIAKALSPNAQKKKYNRKINYWEFEENGKKTTVLSAVGHLYSLTSASSR 63 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGK--EKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 L + W YEV K ++ +K+L++ AD A D D EG I ++ Sbjct: 64 DRLGFDLT------WVPAYEVEKQKYTRDYINAIKKLSKGADKFVHACDYDVEGTLIGYN 117 Query: 123 LREVIGGDDARYS--RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 + G++A R+ F+ +TK I +A+N +++I +V+ AR +D G +S Sbjct: 118 ALKYACGNNAEAKASRMKFSTLTKKDIVEAYNTMRDIDIRQVDHGIARHMLDYYYGMNIS 177 Query: 181 PLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEAL 234 L K + LSAGRVQ+ + ++V+RE+EI++FVPE +W + A + Sbjct: 178 SALMKAVRASSSRFISLSAGRVQTPTLSILVDREKEIQSFVPEPYWMIKAKSDYDIIADH 237 Query: 235 ALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAAS 294 + ++E+ + + + A V + + KP PF LQ A Sbjct: 238 V---------EGKIFDEERAKKIYADCQGADADVTSVKVTESIRKPPIPFNLGGLQSEAH 288 Query: 295 TRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVNMVRGYISDNFGKKYLPESP 352 T GF K+T + AQ LY GY +Y RT S L + D N+ G D KK++ + P Sbjct: 289 TVFGFSPKRTQVAAQNLYVGGYTSYPRTSSQKLPESLDFKNIFAGLAKDPEFKKHIFDLP 348 Query: 353 --NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDS 410 + + + AH AI P+ V ++ AD K+Y LI +F++ +K ++ Sbjct: 349 AKLKPNEGKKTDAAHPAIHPTGVLP-----SNLSADEAKIYSLIVYRFISVFSENSKLET 403 Query: 411 TTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHF 470 + + D + + + ++GW K P ++ E+ P +NKGD L + ++ + Sbjct: 404 MKVNLKVADEKFTFSRKRVSYEGWLKHYPFKKQ--ENDAFPPINKGDQLKIHKILVEEKE 461 Query: 471 TKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRL 530 TKPPAR++EASL+KELEKR +G +T A I++ + DR Y+ ++ + +G + D L Sbjct: 462 TKPPARYNEASLIKELEKRELGTKATRADIVAKLYDRKYIE--GKKIEVKPLGINIIDTL 519 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 E ++L + + T + E L+ + + + +L++ + L + ++ ++ G + Sbjct: 520 NEYCKDLTSEELTREFERELEGIDTDKYTKEQILENGEKEVKTILAEINQNKKQIGEKLY 579 Query: 591 --QMVLTSIDCPTCGRKMGIRTASTGV--FLGCSGYALPPKERCKTTINLVPENEVLNVL 646 + +CG K+ R + F+GCS + +CK T +L +L Sbjct: 580 GAYQETNVVGECSCGGKLIKRYSPRTKNTFVGCSNFP-----KCKVTYSLPKGANMLKK- 633 Query: 647 EGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDG 706 CP CG M S + + C + G Sbjct: 634 --------------TCPTCGLPMISIKKASGKGRDHVCLDSNCGKDVSRRQAPEVVG--- 676 Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPE 760 +C +CG ++ + GR+G+++ C+ C+ T + + K Sbjct: 677 ---KCPECGKDLLKRSGRYGEFVGCSGFPRCRFTCSVDELNNLGKDKNKEDVKEN 728 Score = 45.1 bits (105), Expect = 0.013, Method: Composition-based stats. Identities = 12/98 (12%), Positives = 25/98 (25%), Gaps = 4/98 (4%) Query: 741 KILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGV--FLAANTFPKSRETRAPLVE 798 + + C + R F+ + FPK + T + L + Sbjct: 569 QNKKQIGEKLYGAYQETNVVGEC-SCGGKLIKRYSPRTKNTFVGCSNFPKCKVTYS-LPK 626 Query: 799 ELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTK 836 + P + + +G + S K Sbjct: 627 GANMLKKTCPTCGLPMISIKKASGKGRDHVCLDSNCGK 664 >UniRef50_C6N6E9 DNA topoisomerase n=2 Tax=Legionella drancourtii LLAP12 RepID=C6N6E9_9GAMM Length = 668 Score = 515 bits (1327), Expect = e-144, Method: Composition-based stats. Identities = 145/677 (21%), Positives = 258/677 (38%), Gaps = 81/677 (11%) Query: 5 LVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 L I E P++AK I LG ++ V VGH+ +L Sbjct: 3 LFICEKPSQAKDIATVLGATTRTDACFEGNEIAVTWCVGHLLELAPPDHY---------- 52 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 RM V P + +K ++ + +L ++A + +ATD D Sbjct: 53 ---------CDSIKPWRMEVLPVVPKQWVLMPQEKTKKQLNAIGKLLKQARSVVIATDAD 103 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFN--KPGELNIDRVNAQQARRFM 171 REG+ I + + R+ + + + +I++A + KPG A R+ Sbjct: 104 REGDVIGREVLDYF-NYQGPVERLWLSALDEESIKKALHSIKPGAATECLYQAGLGRQRA 162 Query: 172 DRVVGYMVSPLLWKKI----ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D ++G ++ + LS GRVQ+ ++LVV+R+ I+ F ++++ + A Sbjct: 163 DWLMGMNLTMAVSSLYALPGQGVLSVGRVQTPTLKLVVDRDLGIEQFKAQDYYVLKALCE 222 Query: 228 TPSGEALALQV---THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPF 284 + E + +D + + K + V ++ P Sbjct: 223 NINQEPFWVTWEIPEELSDDDGKCIQKASIDEVARKINGKAGRVTSFKELDKREAPPLCL 282 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT-YMRTDSTNLSQDAVNMVRGYIS--D 341 S+LQQ AS++LG K T+ +AQ LYE T Y RTD L Sbjct: 283 SLSSLQQLASSQLGLSAKHTLDIAQALYEQHKATSYPRTDCGYLPDSQFAEAGAVFDALK 342 Query: 342 NFGKKYLP------ESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 + LP A + AH I P+ +LK M + +YQLI Sbjct: 343 QIDPEVLPLIERCSLQLKSKAWNSDKITAHHGIIPT--LNPKVNLKTMTESERNVYQLIR 400 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI------ 449 ++A + ++ +T+ + KA + GW + +R +E+ + Sbjct: 401 AYYLAQFLGEYEFVQRQVTLDIEAYTFKASAHLPGVLGWKSAIKPIRDLEEEELDTDASE 460 Query: 450 -LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGI 491 +P ++ + +++ +L P TKP +RF+E SL+ + E GI Sbjct: 461 SIPKLHDQEPVSIQKLKPDSRKTKPKSRFTEGSLIAAMKSIANYIENPQLKKILKETSGI 520 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G +T A+I+ T+ R Y++ + ++ + G + RL + + N TA E L+ Sbjct: 521 GTEATRANILETLLSRAYLKRQGKQLISTPKGRELIQRLPQ---SITNPATTALWEQMLE 577 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 +A + L+ + L + EK ++ CP C + + R Sbjct: 578 DIALGKHALDDFLEEQSDTLSGMLVQLEKQKP---ASHILGSNSTYSCPDCQKTLMKRQG 634 Query: 612 STGVFLGCSGYALPPKE 628 S G + GCSGY Sbjct: 635 SKGAWWGCSGYPQCKTR 651 Score = 49.3 bits (116), Expect = 7e-04, Method: Composition-based stats. Identities = 5/36 (13%), Positives = 13/36 (36%) Query: 759 PELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRA 794 C + R G+ G + + +P+ + + Sbjct: 618 STYSCPDCQKTLMKRQGSKGAWWGCSGYPQCKTRFS 653 >UniRef50_UPI0000DB782E PREDICTED: similar to topoisomerase (DNA) III alpha n=3 Tax=Neoptera RepID=UPI0000DB782E Length = 958 Score = 515 bits (1327), Expect = e-144, Method: Composition-based stats. Identities = 148/838 (17%), Positives = 285/838 (34%), Gaps = 92/838 (10%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 L + E AK I YL I + S K ++ + Sbjct: 2 NVLNVAEKNDAAKNIAAYLSRGTYKRREGLWLYNKIFEF-NSYLWNKNCHMIMTSVSGHL 60 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEVL---PGKEKVVSELKQLAEKADHIYLATDLDRE 115 + G P ++A K+ L++ +K + + + TD DRE Sbjct: 61 LNCEFVGIYRKWQSCHPLSLFDAPVVKQCSQESSIKIKKTLEKEVQKCNALIIWTDCDRE 120 Query: 116 GEAIAWHLREVIG--GDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 GE I + + +V + R R F+EIT+ ++ ++ E + +A R +D Sbjct: 121 GENIGFEIIQVCRAIKPNIRIYRAKFSEITQTSVNRSLQNLCEPDKAISDAVDVRSELDL 180 Query: 174 VVGYMVSPLLWKKIARG---------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 +G + ++ + +S G Q + VVER I+ F E +W++ Sbjct: 181 RIGAAFTRFQTLRLRKVFPTTLADMLISYGSCQFPTLGFVVERFLAIEEFKIEPYWKIKV 240 Query: 225 STTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPF 284 + ++++ + K F + E LE+ +V + KPT+ P Sbjct: 241 MDIRDN---ISVEFKWERGKLFEKLPCEIFLDI--CLEQPNATVQKISSKPTSKWRPLPL 295 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAV------NMVRGY 338 T L++ S +L K+ M +A++LY G I+Y RT++ ++ + Sbjct: 296 DTIELEKQGSRKLNLNAKEIMRIAEKLYTQGLISYPRTETNIFPKELNLISLVNQQINNP 355 Query: 339 ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 NF ++ L + N + S +AH I P ++ + K+Y+ + R F Sbjct: 356 AWGNFAQQLLEKGVN-PRKGKKSDQAHPPIHPIKY------CDNLNGNEAKVYEFVVRHF 408 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 +AC + A + + + A G + + V + ++ + +G Sbjct: 409 LACLSSNAIGHQVIVEIDIAGEKFNANGLQVIEKNYLDVYIYEKWN--EQKIHNYREGQV 466 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR-VENRRF 517 + + T PP +EA L+ ++K GIG +T+A I TI+ R YV V+ + Sbjct: 467 FKPTSIEMIEEKTSPPQLLTEADLITLMDKHGIGTDATHAEHIDTIKSRQYVGLVDEKYL 526 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT----- 572 K+G + + ++ A++E L + K VL++ + + Sbjct: 527 IPGKLGIGLVLGYDNMGFQMSKPGLRAELERDLKLICEQRKNAKEVLENQINKYRDLFKI 586 Query: 573 -------------QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAST--GVFL 617 D+ +E + CP CG M ++ G ++ Sbjct: 587 SMERANLIDNALADYFDEQPTKIQELENNFPSQDIAIFKCPKCGLDMTLKDRKQGMGKYI 646 Query: 618 GCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK 677 GC GY C I E + + + CG + Sbjct: 647 GCIGYPT-----CNNVIWFPQYIEDVEITDN---------------ICGCDPTFNELLNI 686 Query: 678 RKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGR-------FGKYMA 730 R ++ NP D + + S ++++ +++ Sbjct: 687 RDSNIKSQNPITDDSGYRNTFDKANVSCSTSIGNSGTYSFLNIRNETDLSECNISTEFIR 746 Query: 731 CTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAY---FVLRDGAA--GVFLAA 783 N N K + D + C ++ V ++G F Sbjct: 747 NQNINRNNAMKSRNTKQQHKIWGDIDENSVILCNCNENAIQLIVRKEGPNHGRAFYKC 804 >UniRef50_B7KK14 DNA topoisomerase n=4 Tax=Cyanobacteria RepID=B7KK14_CYAP7 Length = 720 Score = 515 bits (1326), Expect = e-144, Method: Composition-based stats. Identities = 225/745 (30%), Positives = 366/745 (49%), Gaps = 76/745 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M K L ++E+P K K + + LGS+Y+VK+S GHIR+L G + + + Sbjct: 1 MSKKLFLIEAPGKLKKLQQILGSEYIVKASGGHIRELAKDGDDNLGFDLKKDSISCRFMP 60 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 K P K +S+LK+LA + D + LATD DREGE IA Sbjct: 61 K------------------------NPMARKTISQLKELARQVDTVILATDEDREGEIIA 96 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+EV+ + R+ + EIT A++ + N+P L+++ VNA AR +D++VG+ S Sbjct: 97 WHLKEVLNLRNP--QRITYREITPAAVKASLNRPRSLDMNLVNAALARSVLDKLVGFRGS 154 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVT- 239 PL+WK S GRVQS A+ ++ +REREI+ F P+++W V + + + T Sbjct: 155 PLVWKLGNGAKSIGRVQSAALHILCQREREIQEFKPQDYWLVSVTYSEGFKAYYLGEKTS 214 Query: 240 ------------------HQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 + + +++ + VSL + + V+E + K + P Sbjct: 215 TPTDKEENEQRDDAGEKEENKVEATKVLSEAEADRLVSLARQFPHHVIEVQSKTVSKNPP 274 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 APF TS+LQQAA +RL + KTM +AQRLYE GYITYMRTDS +L V+ ++ Sbjct: 275 APFTTSSLQQAAGSRLKWSPDKTMQVAQRLYEGGYITYMRTDSYHLDPQFCATVKQWLQQ 334 Query: 342 NFGKKYLPESPNQYASKENSQEAHEAIRPSDV-NVMAESLKDMEADAQKLYQLIWRQFVA 400 +P + + + +QEAHEAIRP+D+ E +++ A+ +LY LIW + VA Sbjct: 335 K-DPNNIPVKVASHRTSKTAQEAHEAIRPTDIFKPSIELKQEISAEEFELYLLIWLRTVA 393 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALT 460 Q A+ T + +GD +ARG+I+ F G+ K + +D +LP V+ G L Sbjct: 394 SQCKSAQILKTRIITQSGDIFWQARGQIVTFAGYAKYW---KDLSDDLLLPQVSGGQLLN 450 Query: 461 LVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAE 520 L E + T+PP R+SEA LV+ +E+RGIGRPST+A + T+++RGY +V+ R+ A Sbjct: 451 LSEAGHEKKQTQPPPRYSEAKLVQVMERRGIGRPSTFAPTVKTLKERGYAQVQKRQLQAT 510 Query: 521 KMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQL----- 575 +G V L++ EL+ +FTA ME+ LD +A+ + W+ + + D+ Sbjct: 511 PLGLEVDAFLQKTLPELLQAEFTALMEDKLDAIASGKENWERYIIGWNEDYFAVALLKAL 570 Query: 576 ------DKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV-----FLGCSGYAL 624 + K+ + + + + I+CP C KM + + FL C Sbjct: 571 KVVGSQASSSKNSQSLEAKGHSNKESKINCPHCSHKMLEIPSKSKKLHKDYFLKCPSCQA 630 Query: 625 PPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDP---KRKLH 681 I +P + +++ + + CP CG + + K+++ Sbjct: 631 VMFYNKWRKIWELPGEK------SQESTPSLKLTQHSCPVCGEKLAVREYEKEGVKKQML 684 Query: 682 VCGNNPTCDGYEIEEGEFRIKGYDG 706 VC + P G + + + + Sbjct: 685 VCSS-PKAKGDKKHKEVVYFESKNV 708 >UniRef50_Q9PHK2 DNA topoisomerase I, plasmid n=3 Tax=Gammaproteobacteria RepID=TOP1P_XYLFA Length = 660 Score = 515 bits (1325), Expect = e-144, Method: Composition-based stats. Identities = 221/721 (30%), Positives = 332/721 (46%), Gaps = 80/721 (11%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L+I+ESP K + ++ LG + + +SVGH+RDLP Sbjct: 2 KLMIIESPGKIEKLSTILGDGWKIAASVGHVRDLPQKEMGVAAP---------------- 45 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123 +++ YE+ E VV++LK L ++AD +YLATD DREGEAI+WHL Sbjct: 46 --------------DFKPSYELTERGEGVVAKLKNLLKQADSVYLATDPDREGEAISWHL 91 Query: 124 REVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPLL 183 ++ + + RV FNEIT NA++ + P +++ RV AQ+ARR +DR+VGYMVSP L Sbjct: 92 QQCLKLSNP--LRVTFNEITANAVKASLVAPRTIDVKRVAAQEARRVLDRLVGYMVSPEL 149 Query: 184 WKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPS--GEALALQVTHQ 241 + + LSAGRVQS AVRLVVEREREIKAF + GE A +T Sbjct: 150 SRLTGKRLSAGRVQSPAVRLVVEREREIKAFKVTNHFGAMLFFADAKTSGEWSAEWLTKP 209 Query: 242 NDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGV 301 A ++ + V ++ P PF TST+QQAAS LG Sbjct: 210 KFVAEDNPYFMDRDFAAAVAQVKAVVVKSFDESEAKRSPPPPFTTSTMQQAASVTLGVDP 269 Query: 302 KKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKENS 361 K M AQ+LYE G+ITY RTD+ N+S +++ + Y + E P ++ + + Sbjct: 270 KAAMDAAQKLYEQGHITYHRTDNPNVSDESLGDI--YAVSVKLGLDIAEKPRKFKAPAGA 327 Query: 362 QEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG--- 418 Q H A+ P+ V +D + LY+LI + +ACQ+ A+Y T+ + A Sbjct: 328 QVGHPAVTPTHWEVEEAGE---TSDQKALYKLIRLRAIACQLADARYAVRTVRLEAAQPV 384 Query: 419 ---DFRLKARGRILRFDGWTKVMPALRKGDED-------RILPAVNKGDALTLVELTPAQ 468 + +ARGR L + GW K++ + +ED +P G+ L + + Sbjct: 385 GGKNVEFEARGRTLIYQGWLKLIAGDQTEEEDGNEKESSNPIPVCAPGECLDVARGKLLE 444 Query: 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528 TKPP+ +++A+LVK+LE GIGRP+TYA+I+ I RGYV+ E + + + GE++ D Sbjct: 445 KKTKPPSHYTQATLVKKLESEGIGRPATYAAIMDNIVSRGYVKTEKKYLFPTETGELIVD 504 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMR 588 L F E ++ FT ++E SLD++A E+ +KAV+ +L Sbjct: 505 SLVGKF-EFLDLGFTREIEESLDRIAQGESGYKAVIAKVHDQLNMELSTL---------- 553 Query: 589 PNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEG 648 C CG+ + G F GCSGY C T + Sbjct: 554 -QVSATPKHPCQECGKPLRRIPGKNGHFWGCSGYP-----DCSVTFP--------DEGGK 599 Query: 649 EDAETNALRAKRRCPKCGTAMDSYLIDPKRK--LHVCGNNPT-CDGYEIEEGEFRIKGYD 705 + + C KCG + + K C C ++ Sbjct: 600 PGQKKPVEVSNFACVKCGNPLKHLVKKGKGGYDFWGCSGFKEGCKATYEDKKGKPNFEKA 659 Query: 706 G 706 Sbjct: 660 K 660 Score = 66.3 bits (160), Expect = 5e-09, Method: Composition-based stats. Identities = 19/91 (20%), Positives = 36/91 (39%), Gaps = 8/91 (8%) Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 P C++CG + G+ G + C+ +C T + P ++ PV + C K Sbjct: 559 PKHPCQECGKPLRRIPGKNGHFWGCSGYPDCSVTFP---DEGGKPGQKKPVEVSNFACVK 615 Query: 766 SDAYF--VLRDGAAGV-FLAANTFPK-SRET 792 +++ G G F + F + + T Sbjct: 616 CGNPLKHLVKKGKGGYDFWGCSGFKEGCKAT 646 Score = 62.0 bits (149), Expect = 1e-07, Method: Composition-based stats. Identities = 17/110 (15%), Positives = 32/110 (29%), Gaps = 6/110 (5%) Query: 644 NVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKG 703 + + K C +CG + + C P C +EG + Sbjct: 545 QLNMELSTLQVSATPKHPCQECGKPL-RRIPGKNGHFWGCSGYPDCSVTFPDEGGKPGQK 603 Query: 704 YDGPIVE--CEKCGSEM--HLKMGRFGK-YMACTNEECKNTRKILRNGEV 748 + C KCG+ + +K G+ G + C+ + Sbjct: 604 KPVEVSNFACVKCGNPLKHLVKKGKGGYDFWGCSGFKEGCKATYEDKKGK 653 Score = 61.7 bits (148), Expect = 1e-07, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 32/105 (30%), Gaps = 12/105 (11%) Query: 757 PLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLAD 816 P+ PC++ G G F + +P T +E + + P Sbjct: 557 ATPKHPCQECGKPLRRIPGKNGHFWGCSGYPDCSVT---FPDEGGKPGQKKP----VEVS 609 Query: 817 APQQDPEGNKT--MVRFSRKTKQQYVSSEKDGKATGWSAFYVDGK 859 GN +V+ + + S G G A Y D K Sbjct: 610 NFACVKCGNPLKHLVKKGKGGYDFWGCS---GFKEGCKATYEDKK 651 >UniRef50_Q18AW1 DNA topoisomerase n=19 Tax=Bacteria RepID=Q18AW1_CLOD6 Length = 696 Score = 514 bits (1324), Expect = e-144, Method: Composition-based stats. Identities = 144/679 (21%), Positives = 253/679 (37%), Gaps = 90/679 (13%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 LVI E P+ A+TI LG S Y+V VGH+ L + + ++ Sbjct: 2 ILVIAEKPSVAQTIAAVLGVKEKKDGFLTGSGYIVSWCVGHLVGLAEAAAYGEQYKKWNY 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLAT 110 P+ E Y V KEK LK+L +AD + A Sbjct: 62 DSLPILPQ-------------------EWKYTVAADKEKQFKTLKELMHRADVSEVVNAC 102 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQQAR 168 D REGE I + E+ G R+ + + +AI++ F++ + + R Sbjct: 103 DAGREGELIFRFVYEMAGC-KKPMRRLWISSMEDSAIKEGFSRLKNGKEYDALFASALCR 161 Query: 169 RFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D ++G + L L+ GRVQ+ ++++V+R+ I F E+++ V + + Sbjct: 162 AKADWLIGINATRLFSVLYNHTLNVGRVQTPTLKMLVDRDAAITTFKKEKYYHVRLALSG 221 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 + R NK + + E ++ + T+ P F ++ Sbjct: 222 AEAAS------------ERISNKAEADTLKTTCEASKAVCTSLLKEKKTAAPPKLFDLTS 269 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LQ+ A+ G+ K+T+ +AQ LYE +TY RTDS+ L+ D + G I GK Sbjct: 270 LQREANCLFGYTAKQTLDLAQALYEKRLLTYPRTDSSYLTDDMGDTAAGIIKLLCGKFPF 329 Query: 349 PESP-----NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQM 403 H AI P+ + + L + + + + + + Sbjct: 330 MAGKDFTPELAKVLNSKKVSDHHAIIPT-MELAKTDLAALPESERNILTIAGARLIMATA 388 Query: 404 TPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP------------ALRKGDEDRILP 451 P +++ T ARG+ + DGW ++ D ++ LP Sbjct: 389 APHTFEAVTAVFECAGQSFTARGKTVLSDGWKEIDRKYRAILKSKPETDDADSDTEKTLP 448 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------EKRGIGRPSTYAS 499 +G +H T PP +EASL+ + E++G+G P+T A+ Sbjct: 449 PFTEGQNFDNPAAKVTEHDTTPPKPHNEASLLSAMERAGSEDTDPDAERKGLGTPATRAA 508 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 +I + G+V + ++ K G + L + L + TA+ EN+L Q+A +A+ Sbjct: 509 VIEKLVKGGFVERKGKQLLPTKDGINLVCVLPDT---LTSPQLTAEWENNLTQIAKGKAD 565 Query: 560 WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC 619 A + + + E R + CP CG + + C Sbjct: 566 PAAFMKGIEDMARELVKTYPFLSEADKGRFKEEKPELGKCPRCGSPVY--EGKKNYY--C 621 Query: 620 SGYALPPKERCKTTINLVP 638 S + C T+ Sbjct: 622 SN------KECSFTMWKND 634 >UniRef50_C5QM86 DNA topoisomerase n=2 Tax=Staphylococcus RepID=C5QM86_STAEP Length = 712 Score = 513 bits (1322), Expect = e-144, Method: Composition-based stats. Identities = 160/770 (20%), Positives = 270/770 (35%), Gaps = 110/770 (14%) Query: 1 MGKALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M K+L++ E P+ A+ I L Y+V ++GH+ + Sbjct: 1 MMKSLILAEKPSVARDIADALHIKNKKNGYIENEKYIVTWALGHLVTNAAPEQYDASYKE 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIY 107 PK V+ K +K L +K I Sbjct: 61 WKLEDLPIIPKY-------------------MKTIVIGKTSKQFKIVKSLILDKKVKDII 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQ 165 +ATD REGE +A + + +G + R+ + +TK AI++ F + +A Sbjct: 102 IATDAGREGELVARLILDKVG-NKKPIQRLWISSVTKKAIQEGFKHLKDGRAYNSLYHAA 160 Query: 166 QARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 AR D +VG + L K LS GRVQ+ ++LV R+ +I F PE+++ + Sbjct: 161 LARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVQSRQDDINHFQPEKYYTLSIK 220 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 + NK+ + ++ V++ + K P + Sbjct: 221 VDG---------YEFTFNTQKHFKNKKDLETIEQQVKNQEGKVIDVKSKHKKLYPQQLYN 271 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYISDNFG 344 + +QQ A R G K+T+ Q LYE I TY RTDS L+ D V+ ++ + Sbjct: 272 LTDIQQDAYRRFKMGPKETLNTLQHLYERHKIVTYPRTDSNYLTHDMVSTIKERLQALLA 331 Query: 345 KKYLPE---------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIW 395 Y SP ++ H AI P++V SL+ + K+Y LI Sbjct: 332 TNYKSHVRELIGQSFSPKMSIFNDSKVSDHHAIIPTEVRP---SLEQLSQREFKIYMLIV 388 Query: 396 RQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNK 455 +F+ M P +Y+ T+ GD + I + G+ + + + Sbjct: 389 ERFLESLMKPYEYEGVTVNFEVGDLMFSLKENIPKQLGFKALKEDTLQPSKS---HQFVI 445 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKELEK-------------------RGIGRPST 496 G + ++ +H TKPP F+E SL+K +E GIG +T Sbjct: 446 GQQFKVQKVDIHEHETKPPEYFNEGSLLKAMENPQNYIQLDNKKYAQTLKQTGGIGTVAT 505 Query: 497 YASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 A II + + + V + + G+ + + EL + TAQ E L Q+ Sbjct: 506 RADIIDKLFNMNALEVRDGKIKVTSKGKQILELAP---SELTSPLLTAQWEEKLTQIEKG 562 Query: 557 EAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVF 616 K +D + K + + LT+ +CPTCG+ M G Sbjct: 563 RYNSKKFMDEMKHFTKDIVQKI----KSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQM 618 Query: 617 LGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDP 676 L C CKT N+ + RCP C M + Sbjct: 619 LVC------QDPSCKTKKNIQR------------------KTNARCPNCKKKMTLFGRGK 654 Query: 677 KRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG 726 + + + + + G + G++ + F Sbjct: 655 EAVYRCVCGHSETQAQMDKRMKEKSSGKVSRKEMKKYMGNQEEIDNNPFK 704 Score = 42.8 bits (99), Expect = 0.065, Method: Composition-based stats. Identities = 16/123 (13%), Positives = 32/123 (26%), Gaps = 20/123 (16%) Query: 720 LKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGV 779 ++ GR+ + T+ I++ + + K L C + + G Sbjct: 559 IEKGRYNSKKFMDEMK-HFTKDIVQKIKSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQ 617 Query: 780 FLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKTKQQY 839 L P + + + + P K M F R + Y Sbjct: 618 MLVCQ-DPSCKTKKNIQRKTN------------------ARCPNCKKKMTLFGRGKEAVY 658 Query: 840 VSS 842 Sbjct: 659 RCV 661 >UniRef50_C0FN62 DNA topoisomerase n=31 Tax=Bacteria RepID=C0FN62_9FIRM Length = 709 Score = 513 bits (1321), Expect = e-143, Method: Composition-based stats. Identities = 140/674 (20%), Positives = 249/674 (36%), Gaps = 86/674 (12%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 LV+ E P+ A +++K +G + Y+V VGH+ +L + +K A Sbjct: 19 KLVLAEKPSVAMSLSKVIGADQRGDGYMEGNGYLVSWCVGHLVELSQPEAYDEKYAKWKY 78 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIYLAT 110 P+ Y+V +K LK+L + + + AT Sbjct: 79 DDLPILPEH-------------------WQYQVSASTKKQFGILKKLMQRKDVESLICAT 119 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQAR 168 D REGE I + G R+ + + +AIR+ F K A R Sbjct: 120 DAGREGELIFRLVYHQCGC-KKPVERLWISSMEDSAIREGFQKLRPGTEYDALYEAALCR 178 Query: 169 RFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D +VG + L + L+ GRV + + +VV R+ I+AF PE F+ + Sbjct: 179 ERADWIVGINATRLFSCLYGQTLNVGRVMTPTLAMVVMRDAAIRAFKPEPFYSAELKFR- 237 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 Q E + + + + E K + KP A F ++ Sbjct: 238 ----------DFQAGGERMKEKAEAEKLVAECCQAGSAIITKVEQKEKSEKPPALFDLTS 287 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LQ+ A+ +LGF ++T+ Q LYE +TY RTDS L+ D +V +S + Sbjct: 288 LQREANRQLGFTAQQTLDYTQALYEKKLVTYPRTDSRYLTDDMAPLVPELVSVIQQSFQI 347 Query: 349 PESPNQYAS-----KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQM 403 + H AI P+ + + + Q + ++ + + Sbjct: 348 QPDAPAPVNTAQVINTKKVTDHHAIIPTKTAAGY-DISSLPSGEQAILTMLTVRLICAVG 406 Query: 404 TPAKYDSTTLTVGAGDFRLKARGRILRFDGWT----KVMPALRKGDEDRILPAVNKGDAL 459 TP +Y T + + + +G+ + GW K + K E LP +++G L Sbjct: 407 TPCRYAETIVEAECAGQKFRTKGKTVTDMGWRQYAGKAVEDAEKNAEAGELPILSEGMTL 466 Query: 460 TLVELTPAQHFTKPPARFSEASLVKEL------------EKRGIGRPSTYASIISTIQDR 507 L + + T PP RF+E L+ + E++GIG P+T A+II + + Sbjct: 467 ELAGVDLKEGKTSPPKRFTEDLLLSAMESASSDEFPAGVERKGIGTPATRAAIIEKLVQK 526 Query: 508 GYVRVEN----RRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 G++ + + G + + E ++ + TA E L ++ + E + A Sbjct: 527 GFIERRGDKKTKYLCSTDKGNALVTVVPE---QIQSPSMTADWEEKLLKIEHGEYDSDAF 583 Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYA 623 + S + + + + + CP CG + + G F C Sbjct: 584 MGEISSMVSGLVKT-YEAVKGADVLMQPECKVIGSCPACGSDVC--ETAKGWF--C---- 634 Query: 624 LPPKERCKTTINLV 637 + CK + Sbjct: 635 --RDKSCKFALWKE 646 >UniRef50_A6GUS8 DNA topoisomerase n=1 Tax=Limnobacter sp. MED105 RepID=A6GUS8_9BURK Length = 670 Score = 513 bits (1320), Expect = e-143, Method: Composition-based stats. Identities = 140/698 (20%), Positives = 249/698 (35%), Gaps = 88/698 (12%) Query: 5 LVIVESPAKAKTINKYLGSDYV------------------VKSSVGHIRDLPTSGSAAKK 46 L I E P+ K I K LG V V GH+ ++ ++ Sbjct: 3 LFIAEKPSMGKEIAKNLGGKMVNQGPAGKPPTHIEVGGDVVTWGFGHLLEMAPPEHYSEA 62 Query: 47 SADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHI 106 + P + +S +K L +KA + Sbjct: 63 FKKWS-------------------FDTLPIEPKSFELLPKSNAKAQISTIKALLKKASTV 103 Query: 107 YLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRV---- 162 A D DREG+ + L E G + R++ + + ++++A + Sbjct: 104 VNAGDPDREGQWVVDSLLEHFG-NTKPVQRIILQALDEVSVKKALANLQPNTSPQFIGWK 162 Query: 163 NAQQARRFMDRVVGYMVSPLLWKKI---ARGLSAGRVQSVAVRLVVEREREIKAFVPEEF 219 N+ R+ D G ++ + +S GRVQ+ + LVV R+ I+ F P++F Sbjct: 163 NSAIGRQRSDWFWGMNLTRAHTLVSNVKGQVVSIGRVQTPTLGLVVARDLAIENFKPKDF 222 Query: 220 WEVDASTTTPSGEALALQVTHQN---DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPT 276 + V A A D+ R ++ Q + ++ SV E Sbjct: 223 YAVSAQIVGAEPVFSAKWKPSDAVPVDESGRVLDANIAQTVCAKIKSQTASVTAFEAVDK 282 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVR 336 P+ S+LQ AAS +LG G ++ + +AQ LYE +Y RTD L + Sbjct: 283 KQSAPLPYSLSSLQLAASKKLGLGAQRVLDIAQTLYEQKLTSYPRTDCPYLPESQHASA- 341 Query: 337 GYISDNFGKKY------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKL 390 I+ +KY S A ++ AH I P+ ++ + + Sbjct: 342 ELIAKCLPEKYSELVKGASFSIKSGAWNDSKVTAHHGIIPTGQK------ANLSGELAAV 395 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM--PALRKGDEDR 448 Y +I ++A P Y TT+++ + A G+ GW V +G++ + Sbjct: 396 YDMIVLAYLAQFYPPFVYKQTTISLEVAGEKFTASGKAPISQGWKVVFGSEESEEGEDKQ 455 Query: 449 ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGI 491 LP + G +L T PP RF+E +L++ + E GI Sbjct: 456 TLPVLQVGQSLICETAQVDAKKTTPPLRFTEGTLIQAMTNVHQLVDDPEIKKRLKETAGI 515 Query: 492 GRPSTYASIISTIQDRGYVR-----VENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546 G +T A+II T++ R ++ + + + + G + +L + L + T Sbjct: 516 GTEATRANIIETLKMRKFIEIPDSGKDKGKLVSTQNGRKLIAKLPD---SLKSAGITGLF 572 Query: 547 ENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKM 606 E +L+ VA E ++ + + ++ A K+ + + K+ Sbjct: 573 EQALESVAKGETSLDVFMEKQTAFVKKYVEMARKEAPATASASTPVAPSVGCPVCEKGKL 632 Query: 607 GIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 + S G F GCSG+ K C + Sbjct: 633 RLLNGSKGAFWGCSGFRDGCKTTCPDLSGKPDLGKFAK 670 >UniRef50_B1ZYV6 DNA topoisomerase n=11 Tax=Bacteria RepID=B1ZYV6_OPITP Length = 939 Score = 512 bits (1318), Expect = e-143, Method: Composition-based stats. Identities = 151/685 (22%), Positives = 265/685 (38%), Gaps = 95/685 (13%) Query: 3 KALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+LVI E P+ A + + LG YVV +VGH+ +L Sbjct: 2 KSLVIAEKPSVAADLARALGKIPKQGDHYENDQYVVSYAVGHLVELEMPED--------- 52 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIYLA 109 D++ R+ P + + + + + LK+L + + + A Sbjct: 53 ---------IDKKKYGFWRLETLPIIPEKFGLKPIEESKDRFNALKKLLARKDIELVINA 103 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI--DRVNAQQA 167 D REGE I +L ++ R +T IR+AF + A + Sbjct: 104 CDAGREGELIFAYLYQLTKC-KLPVKRAWMQTMTAEGIREAFAHLRDGEQMAGLAAAARC 162 Query: 168 RRFMDRVVGYMVSPLLWKKI-----ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 R D ++G + L K++ S GRVQ+ + +V RE EI+ F P +W++ Sbjct: 163 RSESDWLIGINGTRALTKRMFGSRAGNVASVGRVQTPTLAIVYSRELEIRNFKPRAYWQI 222 Query: 223 DASTTTPSGEA--------LALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDK 274 A+ +G ++D+ R + +A V+ + + + E K Sbjct: 223 TATFEVTNGRYEGTYQRPDFKKSDADEHDRVDRIWEQAVAEAIVAACQGQPPAAVREEKK 282 Query: 275 PTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAG-YITYMRTDSTNLSQDAVN 333 +T + +TLQ+ A+ R G ++T+ +AQ LYE ITY RTDS L +D + Sbjct: 283 ASTQIAPRLYDLTTLQREANNRFGLSARRTLQIAQALYERHKMITYPRTDSRALPEDYIP 342 Query: 334 MVRGYISDNFG------KKYLPES---PNQYASKENSQEAHEAIRPSDVNVMAESLKDME 384 VR + + G ++ L + PN+ H AI P+ K ++ Sbjct: 343 TVRETLKNLHGPLAPHAQQVLDQGWVRPNRRIFNNAQISDHFAIIPTAH-----EAKHLD 397 Query: 385 ADAQKLYQLIWRQFVACQMTPAKYDSTT-LTVGAGDFRLKARGRILRFDGWTKVMPALRK 443 K++ +I R+FVA PA++D TT ++ AG K G++L GW V Sbjct: 398 EMEAKVFDMIARRFVAAFFPPAEFDITTRISTVAGRHEFKTEGKVLTVPGWLAVYGRTTV 457 Query: 444 GDE---DRILPAVNKGDALTLV------------ELTPAQHFTKPPARFSEASLVKELE- 487 D+ + LPA++ D T+ + TKPP R++EA+L+ +E Sbjct: 458 EDDAPGSKSLPALSDADRATVARGDDAPAQAKTLDPVLHAETTKPPPRYTEATLLSAMEG 517 Query: 488 ---------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 +RG+G P+T A I + ++ Y+ R E + L Sbjct: 518 AGKLVDDEDLAEAMKERGLGTPATRADTIDGLINQKYMERGQRELIPTAKAEQLLQFLSA 577 Query: 533 NFRE-LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 + L + T + E L Q+ + + + + +D+ + E+ Sbjct: 578 VHTDALTSPAMTGEWEFKLRQIEHGKFSREEFMQEVVEQTKGIVDRVKNFEEDDSAARET 637 Query: 592 MVLTSIDCPTCGRKMGIRTASTGVF 616 + + D + + G F Sbjct: 638 DIPSPTDNKPLRETLRGYKSHDGEF 662 >UniRef50_D1W4E5 DNA topoisomerase n=30 Tax=Bacteroidales RepID=D1W4E5_9BACT Length = 714 Score = 512 bits (1318), Expect = e-143, Method: Composition-based stats. Identities = 151/729 (20%), Positives = 264/729 (36%), Gaps = 84/729 (11%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 M +I E P+ A+ I + +G Y V + GH+ L + Sbjct: 20 MKT--IIAEKPSVAREIARIVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGVRGFV 77 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLA 109 + + G Y+ G + +K+L + ++HI +A Sbjct: 78 RDNLPIIPDTFTLVPRQVRTEKG----------YKPDSGVVSQIKVIKRLFDTSEHIIVA 127 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQA 167 TD REGE I +L G + R+ + +T AIR+ K + + A +A Sbjct: 128 TDAGREGELIFRYLYHYTGCTT-PFVRLWISSLTDKAIREGLRKLEDGSKYDNLYLAAKA 186 Query: 168 RRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 R D +VG + L G S GRVQ+ + +V ER E + F E FW + +T Sbjct: 187 RSESDWLVGINGTQALSIAAGHGTYSVGRVQTPTLAMVCERYWENRRFTSEAFWLLHIAT 246 Query: 227 TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKA-RYSVLEREDKPTTSKPGAPFI 285 GE + + + + KE + ++ A +V + E K T + + Sbjct: 247 DGCDGEVVKFSSSEKWKE------KEPAMELYNKVKAAGCATVTKAERKEKTEETPLLYD 300 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS----D 341 +TLQ+ A+ + GF ++T+ +AQ+LYE ITY RT S + +D + ++ Sbjct: 301 LTTLQKEANAKHGFTAEQTLEIAQKLYEKKLITYPRTGSRYIPEDVFAEIPKLLAFIGTQ 360 Query: 342 NFGKKYL--PESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFV 399 K + +P + + + H A+ + E + + +YQ+I + V Sbjct: 361 PEWKDKVRAKAAPTRRSVDDGKVTDHHALLVTG-----EKPLFLSKEDNTIYQMIAGRMV 415 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 D TT+T +G +++ GW V + E+ +P +GD L Sbjct: 416 EAFSEKCVKDVTTVTAECAGVEFTVKGSVVKQTGWRAVYGEEK---EEITIPGWQEGDTL 472 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRPSTYASIIST 503 T + + TKP +EA+L+ +E GIG P+T ASII T Sbjct: 473 TPKGSSITEGKTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDCGIGTPATRASIIET 532 Query: 504 IQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV 563 + RGY+ + + G + ++ + + T + E L ++ E Sbjct: 533 LFKRGYMERCKKSLVPTEKGLALNSVVKTM--RIADVAMTGEWEKELARIERGELSADTF 590 Query: 564 LDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYA 623 + + + + G R + CP CG R G + C Sbjct: 591 RKEIEAYTREITSELLSCDKLFGSRD-----SGCACPKCGTG---RMRFYGKVVRCDNTE 642 Query: 624 LP-PKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRC---------PKCGTAMDSYL 673 P R K L + + EG ++K+ + T Sbjct: 643 CGLPVFRLKAGRTLSDDEIKDLLTEGHTKLLKGFKSKQGKSFDAVVAFDGEYNTTFVFPE 702 Query: 674 IDPKRKLHV 682 +K Sbjct: 703 AKKGKKFSG 711 >UniRef50_O28469 DNA topoisomerase 1 n=8 Tax=Euryarchaeota RepID=TOP1_ARCFU Length = 663 Score = 511 bits (1317), Expect = e-143, Method: Composition-based stats. Identities = 167/707 (23%), Positives = 280/707 (39%), Gaps = 61/707 (8%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L+I E A+ I L D V G + S + + + D Sbjct: 6 LIITEKDNTARRIASILFKD-VKTLKKGRV-----SYYHSPSNDAYVVGLKGHIVELDFP 59 Query: 65 GALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLR 124 L N +A + + S LK++A+KAD + +ATD DREGE I Sbjct: 60 KELNNWTKTPLEKLLQAELVKKVKERTISSILKEIAKKADRVTVATDYDREGELIGVEAL 119 Query: 125 EVIGGDDARYS--RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVSPL 182 E++ + RV ++ +T+ IR AF+KP +++ + NA AR+ +D + G ++ L Sbjct: 120 EIVKSVNPTVKVDRVRYSAVTEKEIRSAFSKPVKVDFNLANAALARQKIDLIWGATLTRL 179 Query: 183 LWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 + R LS GRVQ+ +RL+V+RE EI+ F PE+++E+ A Sbjct: 180 ISVHSGRMGKDFLSVGRVQTPTLRLIVDRELEIQNFKPEKYYEIFAEFEG---------- 229 Query: 239 THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLG 298 P R +KE+ + + + V E + PF T+ + AS Sbjct: 230 -FIAKHPKRYGSKEEAEKLFAKI-GETAKVEEFTRRRMEENRPTPFNTTEFLREASKF-- 285 Query: 299 FGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA----VNMVRGYISDNFGKKYLPESPNQ 354 K M +A+ LY GYI+Y RTD+T + + + L + Sbjct: 286 MSPHKAMNIAETLYMNGYISYPRTDNTVYPPTINLIEIVSALSSVFPREAQIVLSQDKIT 345 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLT 414 + + H I P+ V ++ D +Y+L+ R+F+A A +D + Sbjct: 346 PSRGRRETKDHPPIYPTGVAKR----GELSKDEWTIYELVVRRFLATLAPKAVWDVRRVV 401 Query: 415 VGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPP 474 + + + A GR L GW + + + + LP + KGD L +++ + TKPP Sbjct: 402 LDSNGVKFVANGRQLVEAGWRDIYIYSKAEETE--LPLLKKGDVLRILKKRLEEKETKPP 459 Query: 475 ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENF 534 R+S +SL+K +EK +G ST II + R Y+ F + V + L+E Sbjct: 460 GRYSASSLIKMMEKLNLGTKSTRHEIIQKLVSRRYIH--GNPFRPSETAFSVINVLKETA 517 Query: 535 RELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRP-NQMV 593 + D TA++EN +D +A + V+D Q L + +R + Sbjct: 518 ETITLPDMTAKLENEMDLIAEGKKREPEVVDESREMLLQILRAIDYRKLSKDLREGVKKD 577 Query: 594 LTSIDCPTCGRKMGIRTASTGV-FLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAE 652 CP CG ++ +R + G F+GCS Y C T+ L Sbjct: 578 KIVGKCPECGGELVVRQSKAGKRFIGCSNYP-----DCTFTLPLPQNG------------ 620 Query: 653 TNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEF 699 ++C + C P C+ ++ Sbjct: 621 -TLYITAKQCKEHEIKEVKIRTKKGYWNLGC---PYCNYLNWKKENS 663 Score = 60.9 bits (146), Expect = 2e-07, Method: Composition-based stats. Identities = 15/128 (11%), Positives = 33/128 (25%), Gaps = 4/128 (3%) Query: 618 GCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPK 677 G E + + ++ + + + + +CP+CG + Sbjct: 539 GKKREPEVVDESREMLLQILRAIDYRKLSKDLREGVKKDKIVGKCPECGGELVVRQSKAG 598 Query: 678 RKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECK 737 ++ C N P C +C++ + + G Y C Sbjct: 599 KRFIGCSNYPDCTFTLPLPQNG---TLYITAKQCKEHEIKEVKIRTKKG-YWNLGCPYCN 654 Query: 738 NTRKILRN 745 N Sbjct: 655 YLNWKKEN 662 Score = 58.6 bits (140), Expect = 9e-07, Method: Composition-based stats. Identities = 54/439 (12%), Positives = 108/439 (24%), Gaps = 62/439 (14%) Query: 393 LIWRQFVACQ-MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILP 451 LI + + Q P KY F+G+ P E+ Sbjct: 204 LIVDRELEIQNFKPEKYYEIFAE----------------FEGFIAKHPKRYGSKEEAEKL 247 Query: 452 AVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV- 510 G+ + E T + P F+ ++E K P +I T+ GY+ Sbjct: 248 FAKIGETAKVEEFTRRRMEENRPTPFNTTEFLREASKFM--SPHKAMNIAETLYMNGYIS 305 Query: 511 --RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQV--------------- 553 R +N + + L F S D++ Sbjct: 306 YPRTDNTVYPPTINLIEIVSALSSVFPREAQIVL------SQDKITPSRGRRETKDHPPI 359 Query: 554 ------ANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMG 607 E + ++ +R + + GR++ Sbjct: 360 YPTGVAKRGELSKDEW--TIYELVVRRFLATLAPKAVWDVRRVVLDSNGVKFVANGRQLV 417 Query: 608 IRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE-----DAETNALRAKRRC 662 + P + + ++ + + + + Sbjct: 418 EAGWRDIYIYSKAEETELPLLKKGDVLRILKKRLEEKETKPPGRYSASSLIKMMEKLNLG 477 Query: 663 PKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKM 722 K + +R +H P+ + + K +EM L Sbjct: 478 TKSTRHEIIQKLVSRRYIHGNPFRPSETAFSVINVLKETAETITLPDMTAKLENEMDLIA 537 Query: 723 GRFGKYMACTNEECKNTRKILRNGEVAPPKED-----PVPLPELPCEKSDAYFVLRDGAA 777 + +E + +ILR + +D C + V+R A Sbjct: 538 EGKKREPEVVDESREMLLQILRAIDYRKLSKDLREGVKKDKIVGKCPECGGELVVRQSKA 597 Query: 778 GV-FLAANTFPKSRETRAP 795 G F+ + +P T Sbjct: 598 GKRFIGCSNYPDCTFTLPL 616 >UniRef50_P14294 DNA topoisomerase 3 n=211 Tax=Gammaproteobacteria RepID=TOP3_ECOLI Length = 653 Score = 511 bits (1317), Expect = e-143, Method: Composition-based stats. Identities = 133/667 (19%), Positives = 247/667 (37%), Gaps = 82/667 (12%) Query: 5 LVIVESPAKAKTINKYL-------------GSDYVVKSSVGHIRDLPTSGSAAKKSADST 51 L I E P+ A+ I L G+ VV +GH+ + + + A Sbjct: 3 LFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWCIGHLLEQAQPDAYDSRYARWN 62 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATD 111 P+ + + P K ++ +K+ +A I A D Sbjct: 63 LADLPIVPE-------------------KWQLQPRPSVTKQLNVIKRFLHEASEIVHAGD 103 Query: 112 LDREGEAIAWHLREVIG---GDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQ 166 DREG+ + + + + + R + N++ A+ +A ++ + + Sbjct: 104 PDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVSAL 163 Query: 167 ARRFMDRVVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 AR D + G ++ LS GRVQ+ + LVV R+ EI+ FV ++F+E Sbjct: 164 ARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFE 223 Query: 222 VDASTTTPSGEALALQV------THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 V A TP+ E D+ R +++ + V+ + V DK Sbjct: 224 VKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYNDKR 283 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQD---- 330 + PF S LQ A+ R G + + + Q+LYE ITY R+D L ++ Sbjct: 284 ESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHFAG 343 Query: 331 ---AVNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADA 387 +N + + D + + + +AH AI P+ + ++ + Sbjct: 344 RHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAI----NLTENE 399 Query: 388 QKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED 447 K+Y LI RQ++ A + + + + A+ R L GW ++ + + +E+ Sbjct: 400 AKVYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEEN 459 Query: 448 --RILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EK 488 LP V KGD L + + T+PP F++A+L+ + Sbjct: 460 DGTPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRAT 519 Query: 489 RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN 548 G+G +T A II + RG++ + R ++ G+ + L E D TA E+ Sbjct: 520 DGLGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMA---TRPDMTAHWES 576 Query: 549 SLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGI 608 L Q++ + ++ + Q +D+A++ P Sbjct: 577 VLTQISEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKR 636 Query: 609 RTASTGV 615 + Sbjct: 637 SAKKSPP 643 >UniRef50_C1MSJ2 DNA topoisomerase n=1 Tax=Micromonas pusilla CCMP1545 RepID=C1MSJ2_9CHLO Length = 1243 Score = 511 bits (1315), Expect = e-143, Method: Composition-based stats. Identities = 250/896 (27%), Positives = 376/896 (41%), Gaps = 157/896 (17%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 + LVIVESPAKA ++ KYLG Y V +S GH+RDL Sbjct: 98 RTLVIVESPAKATSVQKYLGQSYQVLASYGHVRDLVEKQG-------------------- 137 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADH-IYLATDLDREGEAIAW 121 V P + + L GK VV + + AE+ + LATD DREGEAIAW Sbjct: 138 ---------SVLPDDGFAMRWS-LQGKSGVVKSIVESAERCGGGVVLATDPDREGEAIAW 187 Query: 122 HLREVIGGDDAR--------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDR 173 H+ E++ +R SRV F E+T++A+ +AF +P E++++ V+A ARR +D Sbjct: 188 HISELLKERGSRKKKDAPTAISRVTFTEVTRDAVVKAFKEPREISVELVHAYLARRALDY 247 Query: 174 VVGYMVSPLLWKKI--ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 + G+ +S +LW+KI + LSAGRVQS A+RL+ ERE I+ V EE+W V A SG Sbjct: 248 LFGFKLSGVLWRKIPSSERLSAGRVQSAALRLICEREMSIERHVKEEYWSVVAGLERASG 307 Query: 232 -------------EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYS--VLEREDKPT 276 L + +K+ +A + + A+ + V E+K Sbjct: 308 VKKSDGDASGRFVAELHRDASGARLAKGAVNSKQIAEAVSNEILAAKDTLYVATVEEKEA 367 Query: 277 TSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-----GYITYMRTDSTNLSQDA 331 T+KP PF TSTLQQ A+ +LGFG +TM AQ+LYE G ITYMRTD ++ DA Sbjct: 368 TTKPKPPFTTSTLQQEANAKLGFGSARTMSAAQKLYEGKGFGEGLITYMRTDGLHVGPDA 427 Query: 332 VNMVRGYISDNFGKKYLPESPNQYAS-KENSQEAHEAIRPSDVNVMAESLK---DMEADA 387 V +R ++ FG Y+P +PN Y ++N+QEAHEAIRP ++ ++ +D Sbjct: 428 VKAIRAVATEEFGASYVPATPNAYKKTQKNAQEAHEAIRPIRAELLPNAVSARLGANSDE 487 Query: 388 QKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF----RLKARGRILRFDGWTKVM----- 438 +LY+LIW + +A QM+ A V + LKA G L F G+ Sbjct: 488 ARLYKLIWSRTMASQMSRAVTRRIAAEVKSASEGCELALKANGSRLLFSGFLAAYAHGGR 547 Query: 439 --PALRKGDEDRILPAVNKGDALTL----------------------------------- 461 + D LP + GD + L Sbjct: 548 TSGDDDRDKRDAWLPELKPGDTINLRAPQSVRVIERDKDAKRGGLAKKKSDQADDEDAVD 607 Query: 462 -----------VELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 +T QH+T+PPAR++E +LV+ +E++GIGRPSTYASI+ + RGYV Sbjct: 608 VSETLSSVDTSAGITALQHWTQPPARYTEGALVRAMEEKGIGRPSTYASIVKVMLKRGYV 667 Query: 511 RVENRR--FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 + E G +V+ L F E ++Y FTA +E+ LD +A+ +AEWK V+ F+ Sbjct: 668 VGGGGKGPLIPETRGRMVSSFLTHFFDEYVDYGFTAGLEDKLDDIASGDAEWKDVMSKFW 727 Query: 569 SDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKE 628 F + + + L + + R + + + + Sbjct: 728 KPFHGDVQGLQNIRTSLVVDVLDATLGAHFFGDDESETKARLDA----IAATAEPPRSEG 783 Query: 629 RCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNP- 687 + + D + LRA RRCP C + C N Sbjct: 784 DA------AAPKRAGDAWKSPDYDPATLRASRRCPACVDGRLGLKLSKNGGFIGCSNYNT 837 Query: 688 --TCDGYEIEEGEF---------RIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEEC 736 C DG I + + ++ G +G Y+ Sbjct: 838 DTKCAYARPISTTNGDDAESMRTDPWLSDGEIGVDPETSRTVSVRRGPYGPYVQLDPTAN 897 Query: 737 KNTRKILRNGEVAPPKED-----------PVPLPELPCEKSDAYFVLRDGAAGVFL 781 + T + V D P+ ++ G G ++ Sbjct: 898 EGTPRTFGLQNVPEVTADKLTLNVALALLKYPMTLGVHPTEGGDVTMKIGPYGWYV 953 >UniRef50_UPI000186EA7F DNA topoisomerase 3-alpha, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186EA7F Length = 901 Score = 511 bits (1315), Expect = e-143, Method: Composition-based stats. Identities = 166/927 (17%), Positives = 311/927 (33%), Gaps = 99/927 (10%) Query: 3 KALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKK 58 L + E AK I+ +L S I + + ++ + Sbjct: 2 TILNVAEKNDAAKNISFFLSKGSARKRESLSVYNKIYEFEFKL-FNQNCKMVMTSVSGHL 60 Query: 59 PKKDERGALVNRMGVDPWHNWEAHYEVLPGKE--KVVSELKQLAEKADHIYLATDLDREG 116 N DP + KE K + LK + D + + TD DREG Sbjct: 61 LNYCFPPTHKNWSTTDPSSLFTVPVNKFCAKENFKTQNNLKNEVKYCDTLIIWTDCDREG 120 Query: 117 EAIAWHLREVIGGDDARYS--RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E I + + +V R F+EIT ++ +A N N +A R +D Sbjct: 121 ENIGFEIIDVCKKVKPNIKIYRAKFSEITSASVMRAINNLEMPNKSLSDAVDVRMELDLR 180 Query: 175 VGYMVSPLLWKKIAR---------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 +G + + + +S G Q + VVER + I F+ E FW ++ Sbjct: 181 IGAAFTRFQSLYLQKKFPDNFKSTVVSYGSCQFPTLGFVVERFKNISQFISEPFWRIEV- 239 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFI 285 S + L + + ++ F E +E V++ + KP + P Sbjct: 240 -KDNSNKNLIVDFNWERNRMFDKSCCEV--LYDKCIESNLAKVIKVDSKPKSKYRPKPLD 296 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYI------ 339 T L++ AS +L K + A++LY GYI+Y RT++ ++ +R + Sbjct: 297 TVELEKLASKKLKINAKLALKTAEKLYTQGYISYPRTETNIFPKEL--DLRPLVQRQTTD 354 Query: 340 --SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 F K L + PN S +AH I P ++ + +Y+LI R Sbjct: 355 SNWGEFALKVLVDGPN-PNQGTKSDQAHPPIHPIKYA------SNLTGVEKNIYELIVRH 407 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 F+AC A+ T + + + A+G ++ + V P ++ L N GD Sbjct: 408 FLACLSKNAEGIETAVEIDLANEIFTAKGLMITARNYLDVYPYDVWNAKEINL--YNVGD 465 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN-RR 516 ++ + T PP +EA L+ +EK GIG +T+A I TI+ R YV ++N + Sbjct: 466 VFKPA-VSLVEGKTNPPELLTEADLIALMEKHGIGTDATHADHIETIKARFYVGLKNDKY 524 Query: 517 FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLD 576 F +G + + E+ + A++E L + +E + VL+ + + + Sbjct: 525 FVPRTLGMGLVEGYNNVGFEMAKPNLRAELEADLSSITRNEKMPQDVLNKHINKYKNIFE 584 Query: 577 KAEKDPEE---------------GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSG 621 + + + + N + + ++C CG M + + CS Sbjct: 585 VVKTNSKNLFEIINSYIQGNNPISSEKENNVPKSPMNCRECGNPMIKEIKNNKISFSCSN 644 Query: 622 YALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG-TAMDSYLIDPKRKL 680 K +C IN+ + + + CPKCG + + Sbjct: 645 -----KSQCLNVINISNTVKDVEI------------TNDSCPKCGSNSKLLKFNFKNKNK 687 Query: 681 HVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNE------ 734 + + C + + + + ++ + + + Sbjct: 688 NRSVKDIGCLNGCDKNLLNVLVDNNSNNGSNTEERTQQQQHQQQQQRTFNNVGDITFPSV 747 Query: 735 ----ECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYF------VLRDGAA-GV-FLA 782 + +++ +L K V + G G F Sbjct: 748 SDIFDSGIGFSPENIPQISSSSSSSSSNNDLSIPKCFCQLPAISRVVTKLGQNHGKLFYT 807 Query: 783 ANT---FPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQ--DPEGNKTMVRFSRKTKQ 837 N K + L + + + + + +V+ Sbjct: 808 CNNQNISNKCNFFQWALPDGQTGNHANNNTREKTTKKNVKSTVSKTKDTNVVKCHCSVST 867 Query: 838 QYVSSEKDGKATGWSAFYVDGKWVEGK 864 + K+G G S F K ++GK Sbjct: 868 KKCVVNKEGPNKGKSFFVCGNKNIDGK 894 >UniRef50_C9LK04 DNA topoisomerase III n=3 Tax=Prevotella RepID=C9LK04_9BACT Length = 705 Score = 510 bits (1314), Expect = e-143, Method: Composition-based stats. Identities = 141/662 (21%), Positives = 245/662 (37%), Gaps = 84/662 (12%) Query: 6 VIVESPAKAKTINKYLG---------------------SDYVVKSSVGHIRDLPTSGSAA 44 +I E P+ A+ I + +G SDYVV ++GH+ L + Sbjct: 5 IIAEKPSVARDIARIVGASNKQEGYLASTPSADFQLEGSDYVVTWAMGHLIALAMPEAYG 64 Query: 45 KKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD 104 + P + + + Y P K + ++ +KAD Sbjct: 65 FSAYKREDLPIRPNPFQLVVRQVRK----------DKEYHDDPAALKQLKVIRSCFDKAD 114 Query: 105 HIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRV 162 I +ATD REGE I ++ + + + R+ + +T AIR+ + PG + Sbjct: 115 RIIVATDAGREGELIFRYIYQHLNCC-KPFERLWISSLTDKAIREGLSNLKPGSSYDNLY 173 Query: 163 NAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 + +AR D +VG S L G S GRVQ+ + +V R + F +W++ Sbjct: 174 YSAKARSEADWLVGINASRALSIARKGGYSLGRVQTPTLAMVCRRYIANRDFSSVPYWKL 233 Query: 223 DASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKA-RYSVLEREDKPTTSKPG 281 T A+ ++ Q A++ L R +V K T + P Sbjct: 234 SVHTEKEGLSLKAI-------GSEDYESEASAQTALATLRSQSRLTVESVARKVTHTAPP 286 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISD 341 + + LQ+ A+ R GF KT+ +AQ LYE TY RT S +S+D V + Sbjct: 287 LLYDLTALQKDANRRHGFSADKTLSIAQSLYEKKITTYPRTGSRYISEDVFEEVPALLRK 346 Query: 342 NFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 K L N ++ H AI P+ E + D +Y ++ +F Sbjct: 347 I--GKTLSNPLNIHSVDNAKVTDHHAIIPTG-----EMPTGLSTDEANIYNMVVTRFAEA 399 Query: 402 QMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPA--------LRKGDED---RIL 450 ++ + + G + GW V ++ D++ L Sbjct: 400 FSPDSEEERMQVRFTDGTNIFTWKACRQISLGWKAVQKELVTDAEKKEKENDDELVLPSL 459 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GIGRP 494 P + +G+ L+LV H TKP ++EA+L+ +E GIG P Sbjct: 460 PDLTEGEVLSLVSAEITAHKTKPKPLYTEATLLSAMENAGKEVKEDDKRKAMAECGIGTP 519 Query: 495 STYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVA 554 +T A+II T+ R Y+R + + + G V + +++ +++ N + T E +L + Sbjct: 520 ATRANIIETLILRDYIRRDKKAIIPTEKGLAVYEIVKD--KKIANAEMTGSWELALAAIE 577 Query: 555 NHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTG 614 + + S ++ E P CP CG++ A Sbjct: 578 AGKMPSERFAQGINSYVGTICEELLSLSSEQKSYPVY------RCPKCGQQSVGIYAKVA 631 Query: 615 VF 616 Sbjct: 632 KC 633 >UniRef50_B7JBJ6 DNA topoisomerase III n=3 Tax=Acidithiobacillus ferrooxidans RepID=B7JBJ6_ACIF2 Length = 699 Score = 510 bits (1313), Expect = e-143, Method: Composition-based stats. Identities = 136/707 (19%), Positives = 250/707 (35%), Gaps = 86/707 (12%) Query: 4 ALVIVESPAKAKTINKYL------GSDYV-------VKSSVGHIRDLPTSGSAAKKSADS 50 L I E P+ K I +YL G+ ++ V GHI + Sbjct: 2 KLYIAEKPSLGKGIAEYLPGSKNKGNGFIQCGVDTVVTWCFGHIFEQEEPDFY------- 54 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLAT 110 T +G R P + + + ++ L +KA + A Sbjct: 55 ----TPDDVPTTPKGKKKWRFEELPIFPEQWKKRAKDDAKAQIKVIRALLKKASSVVNAG 110 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQAR 168 D DREG+ + + E + R+ + + ++R+A + + N+ +AR Sbjct: 111 DPDREGQLLVDEVLEELRW-KGPTLRIWLAALDEQSVRKALASLKDNHDYQNLRNSAEAR 169 Query: 169 RFMDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D ++G ++ + + +S GRVQ+ + LVV R+ +I+ F P++++ + Sbjct: 170 ARADWLMGMNLTRAFTLRNSGAGVVSVGRVQTPTLALVVARDEKIEHFKPKDYYVPRINA 229 Query: 227 TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFIT 286 + L + + + K + A + + +V + + F Sbjct: 230 GFWATWELREDFEGVDAEGYLTDRKAADRLASRAKAEGKATVKDFTSAEKQQQAPLGFSL 289 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 + LQ+ S +LG + + AQ LYE TY RTD L ++ +S Sbjct: 290 AELQKVCSAKLGMSAQSVLDAAQALYEEHKAATYPRTDCRYLPEEQHGDAGQILSGLAKA 349 Query: 346 KY------LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFV 399 + + AH AI P+ M K+Y +I R ++ Sbjct: 350 GFADLVKAADSNRKSAIWNTGKVTAHHAIIPTGSMQ-----GSMSPAVAKVYDIIVRSYL 404 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED---RILPAVNKG 456 A P Y + + KA I GW V ++D + +PA+ KG Sbjct: 405 AQFYPPYVYRAIKALLTCTSEDWKATANIPVSAGWKAVYGMTDDDNDDTPAQPIPALKKG 464 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYAS 499 LT+ + TKPPARF++ SL++ + E G+G +T AS Sbjct: 465 QVLTVQDADVQAKQTKPPARFTDGSLIEAMSNIHKVVEDEAAKAKLKETSGLGTEATRAS 524 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 II T+ RG++ + ++ + + G + L + +L + TA+ E++L V+ Sbjct: 525 IIETLLTRGFLERKGKQILSTQAGRALVHALPK---DLTDPVLTARWEDALSSVSEGRVT 581 Query: 560 WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQM----------------VLTSIDCPTCG 603 + + + ++ A+ G T CP C Sbjct: 582 LQQFEEAQRKFVVRMIEAAKATTVAVGQARPTSGAGRGKSSTGKTRGVGQKTGPACPDCK 641 Query: 604 RKMGIRTASTG-VFLGCSG-----YALPPKERCKTTINLVPENEVLN 644 + G F C G + + T + +NE + Sbjct: 642 KLTITLKTKKGDAFFKCEGCQSCWWPDKQDAKKLGTKWGLEKNEYVR 688 >UniRef50_A4IU08 DNA topoisomerase n=3 Tax=Geobacillus RepID=A4IU08_GEOTN Length = 706 Score = 510 bits (1312), Expect = e-142, Method: Composition-based stats. Identities = 147/731 (20%), Positives = 283/731 (38%), Gaps = 87/731 (11%) Query: 4 ALVIVESPAKAKTINK---------YLG--------SDYVVKSSVGHIRDLPTSGSAAKK 46 +++ E P +A+ + +L + V ++GH+ +L + Sbjct: 2 IVILAEKPDQARKLASPFPHTKGNGFLSIQSCKEFPNGATVTWAIGHLVELKEPEEYRPE 61 Query: 47 SADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHI 106 + P + Y+V K K +K+L ++AD I Sbjct: 62 WKKW-------------------DLATLPIIPGQFEYKVSKDKAKQFQTVKKLLKEADEI 102 Query: 107 YLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNA 164 +ATD REGE IA L + G R R + +T+NAIR+ F + + I + Sbjct: 103 IIATDPAREGENIARLLILMAGCSKKRIKRFWTSSLTENAIRKGFAELKDGKETIHLFHE 162 Query: 165 QQARRFMDRVVGYMVSPLLWKKIAR-----GLSAGRVQSVAVRLVVEREREIKAFVPEEF 219 QAR+ D +VG S L + + S GRVQ+ ++L+ +R++EI+ F PE F Sbjct: 163 AQARQIADWLVGMNASRLYTLLLQQKGIRDVFSVGRVQTPVLKLIYDRQKEIEQFRPEPF 222 Query: 220 WEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSK 279 +E++ T +G ++ + + + + + + + Sbjct: 223 YELEGQFTVKNGTYRGKL--NKRFSSPDELYEAVSPDITKEQQTYQAVIKSVRISEKRTP 280 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYI 339 STLQ + F K + + Q LYE GY++Y RTDS ++++ ++ ++ Sbjct: 281 APKLHSLSTLQSKLNRTKKFSPTKVLELVQSLYEKGYVSYPRTDSQYITEEEYTYLQKHV 340 Query: 340 SDNFGK------KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 D + + P++ H AI P++ ++ + +D +++Y Sbjct: 341 -DQYQQCLGIHVPIRSLQPSKRYVNPEKVSDHYAIIPTEKVPDTKAFETFSSDEKEVYYE 399 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDED----RI 449 I + +A MT YD T + G +GR + GW + + + + I Sbjct: 400 ILKSALAMFMTDYVYDETVIITSVGKQEFVTKGRTEKEMGWKALYQNEKDEESEGEQVAI 459 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR-----------------GIG 492 LP V +G++ +++ Q T+PP +++ L+ ++ G+G Sbjct: 460 LPEVKEGESAK-ADISVKQGMTQPPKPYTQGQLITLMKTAGKYVEDQEMKEALNQVEGLG 518 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 +T A+II T+ R + V+ + + K GEI+ + ++ L + TA+ E L + Sbjct: 519 TEATRAAIIDTLIQRRLIEVKKNQVFVTKKGEILCEAVKGTI--LSKPEMTAKWELFLQE 576 Query: 553 VANHEAEWKAVLDH----FFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGI 608 + + ++ ++ Q E+ + + + T CP C + + Sbjct: 577 IGKGNRSKEVFIEQAKKLCYALIQQASQDVERIDAKQALEEIKKENTIAPCPRCQKGYIV 636 Query: 609 RTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTA 668 F GC+ YA CK T + + + K + K Sbjct: 637 ---DRKTFYGCTEYA----NGCKQTFPKSILGKTITKTHVKQLCEKGKTNKIKGFKGKKT 689 Query: 669 MDSYLIDPKRK 679 D+YL K + Sbjct: 690 FDAYLTLQKGE 700 >UniRef50_Q12Y06 DNA topoisomerase n=1 Tax=Methanococcoides burtonii DSM 6242 RepID=Q12Y06_METBU Length = 780 Score = 510 bits (1312), Expect = e-142, Method: Composition-based stats. Identities = 170/817 (20%), Positives = 308/817 (37%), Gaps = 76/817 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADST-STKTAKKP 59 M + E A I+ L +S I D + + + Sbjct: 1 MTTVVF-TEKNKAAAQISTILSGGSAKRS----IVDGVSVYEFQRDGSLWKIMGLAGHIM 55 Query: 60 KKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI 119 D N VDP + K S + ++++ AD + LA D DREGE I Sbjct: 56 GYDYPEEFHNWRDVDPAALLDTDPVKQINKASFGSAILKISKGADLLVLACDFDREGENI 115 Query: 120 AWHLREVI-GGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 + + + DA R F+ ++K+ I +AFN E + + + +AR+ +D +G Sbjct: 116 GFEAKSIAEKVSDATVKRARFSSLSKSEIEKAFNDLVEPDENMAMSAEARQILDLKMGAS 175 Query: 179 VSPLLWKKI------ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGE 232 + + + LS G Q+ V ERE I+ F +FW+++ T + Sbjct: 176 FTRFVTLSVRERARTKGVLSIGPCQTPTCGFVYERELAIRKFDSRDFWKIEGVFTGKGAD 235 Query: 233 ALALQVTHQNDKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTSKPGAPFITSTLQQ 291 + + + +KE+ A L+ + ++ K + P P T+ + Sbjct: 236 IIGVH------RGGHIYDKEKAAAIFKKLKGCKTAVISKKTVKEMNTNPPFPLNTNEFLK 289 Query: 292 AASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD--AVNMVRGYISDNF---GKK 346 AS LG + + +A++LY +G+ +Y RT++ + D ++++G+ ++ Sbjct: 290 RASKYLGVSPDQALEIAEQLYLSGFTSYPRTETNMYADDMDFASILKGFTKGDYQDFALL 349 Query: 347 YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDME-ADAQKLYQLIWRQFVACQMTP 405 L + + + H I P E + ++ A +Y LI R F+A + P Sbjct: 350 LLSQKAIVPRNGKKDGHDHPPIHPIKAGSRMEVERAIKMPRAWDVYDLIVRHFIANLLPP 409 Query: 406 AKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELT 465 A ++ T + D + G I + GW V P + +D+ILPA++ G+ L + ++T Sbjct: 410 AVFEKTRFEITMEDELFDSTGSIQKNAGWLAVYPFEKP--QDKILPALDLGEVLDVKKIT 467 Query: 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEI 525 + T PP R +EA L+ ++K GIG +T S I T + RGY V+ + G Sbjct: 468 NIKSQTTPPKRLTEAELLTLMDKHGIGTKATAPSHIETNKKRGYFEVKGKTIAILDTGFT 527 Query: 526 VTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 + D L + L+ D + +E+ + V + +++ L+ S + + + + Sbjct: 528 LMDALNSSVPILVKPDIRSSIESLIQDVEDGNKKFELALEEGTSLIKEMYSQLLSNRDLM 587 Query: 586 GMRP----------NQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTIN 635 R C C R + I + G F+GC+GY +CK T Sbjct: 588 VTRIAGTITDEAVEADKKSHIGKCNECERVLRIVSTDKGRFVGCTGYP-----QCKNTFP 642 Query: 636 LVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE 695 L + A++ R C K G A+ G P Sbjct: 643 LPKTGAL------------AVQRSRTCKKGGAAVLKVGSK---YFWAVGIGP-----CFS 682 Query: 696 EGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDP 755 + + EC C + L + +++ CT C +T+ + +NG + + Sbjct: 683 CDMEKECYPPEIVGECPACDGQTFLITTKDSRFLGCTK-RCGHTQSVPKNGRLTITDK-- 739 Query: 756 VPLPELPCEKSDAYF--VLRDGAAGVFLAANTFPKSR 790 CE V G K Sbjct: 740 ------VCEGCGWRLLRVKEQGKDAKEY-CANR-KCE 768 Score = 48.2 bits (113), Expect = 0.001, Method: Composition-based stats. Identities = 9/80 (11%), Positives = 22/80 (27%), Gaps = 12/80 (15%) Query: 753 EDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLR 812 E C + + + G F+ +P+ + T LP+ Sbjct: 601 EADKKSHIGKCNECERVLRIVSTDKGRFVGCTGYPQCKNTFP------------LPKTGA 648 Query: 813 YLADAPQQDPEGNKTMVRFS 832 + +G +++ Sbjct: 649 LAVQRSRTCKKGGAAVLKVG 668 >UniRef50_Q9KQF5 DNA topoisomerase 3 n=109 Tax=Gammaproteobacteria RepID=TOP3_VIBCH Length = 647 Score = 509 bits (1310), Expect = e-142, Method: Composition-based stats. Identities = 129/636 (20%), Positives = 240/636 (37%), Gaps = 84/636 (13%) Query: 3 KALVIVESPAKAKTINKYLGSDY-------------VVKSSVGHIRDLPTSGSAAKKSAD 49 L I E P+ A+ I L + +V +GH+ + + ++ Sbjct: 2 TRLFIAEKPSLARAIADALPKPHKKEQGCIRCANGDIVTWCIGHLLEQVEPDAYDERYKK 61 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLA 109 P+ + + ++ +++L ++A I A Sbjct: 62 WNMADLPIIPE-------------------QWQLRPRKSSSQQLTVVRKLLKEATQIIHA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDAR---YSRVVFNEITKNAIRQAFNKPG--ELNIDRVNA 164 D DREG+ + + + ++ R++ +++ +A+++A I + Sbjct: 103 GDPDREGQLLVDEVIDYCKVPKSKKETVQRLLISDLNLSAVKRALQGLRSNREFIPLSVS 162 Query: 165 QQARRFMDRVVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVPEEF 219 AR D + G +S LS GRVQ+ + LVV R+ EI+ F+P ++ Sbjct: 163 ALARSRADWLYGMNMSRAYTLLGKKAGYQGVLSVGRVQTPVLGLVVRRDEEIEHFIPHDY 222 Query: 220 WEVDASTTTPSG-EALALQVTHQN--------DKPFRPVNKEQTQAAVSLLEKARYSVLE 270 + +DA +G E ++ + D+ R N++ S + +V E Sbjct: 223 FTLDALIPYQNGTEYFDIRARWKPSEACLPWQDEEGRVTNRKLVDNVASRIANQPATVTE 282 Query: 271 REDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQ 329 E T P+ S LQ A+ R F ++ + + Q LYE ITY R+D L + Sbjct: 283 SEQDQTKQAAPLPYSLSALQIDAAKRYNFSAQQVLDLCQSLYEKHKLITYPRSDCRYLPK 342 Query: 330 DAVNMVRGYISDNF--GKKYLPE------SPNQYASKENSQEAHEAIRPSDVNVMAESLK 381 + + ++ ++ + S A ++ +AH AI P+ S+ Sbjct: 343 EHLAQAPDVVAAIANNAQEMVTAVNDADLSLRSKAWNDSKVDAHHAIIPT---PKKASVN 399 Query: 382 DMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPAL 441 + K+YQLI RQ++ A Y L A+GR L GW + Sbjct: 400 ALSGHEMKVYQLIARQYLMQFYPAAIYAEAKLVFNIAGGIFIAKGRQLLSAGWKVLTGQQ 459 Query: 442 RKGDE-DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-------------- 486 + +E +P + G L E Q T+PP F+EA+L++ + Sbjct: 460 DEQEECVDKVPPLPVGIVLQCREGEIKQRQTEPPRHFTEATLLQAMTGIARFVADKELKK 519 Query: 487 ---EKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFT 543 E G+G +T A I+ T+ RG ++ +N+ + G + L E D T Sbjct: 520 ILRETDGLGTEATRAGILDTLFKRGLLQRDNKLIKSTPAGRGLIHALP---SEATYPDMT 576 Query: 544 AQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE 579 A E+ L +A ++ + Q +++ + Sbjct: 577 AHWEHQLQAIAEKGQAYQPFMQTLQGRLEQLIEQVQ 612 >UniRef50_A4JW73 DNA topoisomerase n=1 Tax=Burkholderia vietnamiensis G4 RepID=A4JW73_BURVG Length = 823 Score = 509 bits (1310), Expect = e-142, Method: Composition-based stats. Identities = 177/852 (20%), Positives = 291/852 (34%), Gaps = 125/852 (14%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 MGKAL++ E P+ A I K LG D +V + GH+ + + Sbjct: 1 MGKALIVAEKPSVAADIAKALGGFTKADGYFERDDAIVAPARGHLVEQTVPAA------- 53 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADH--IY 107 + ++GV P EV+ G S LK+L + D + Sbjct: 54 --------------DAKGMWKIGVLPIIPDSFELEVIDGCTAEFSRLKKLMARDDVASVV 99 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQ 165 A D REGE I + G R+ + +AIR+A + +A Sbjct: 100 NACDAGREGELIFRLIYNKAGCR-KPTKRMWIQSMVASAIRKAHDDLRPGAEFDHLSDAA 158 Query: 166 QARRFMDRVVGYMVSPLLW-----KKIARGLS-AGRVQSVAVRLVVEREREIKAFVPEEF 219 R D +VG + K R +S GRVQ+ + + V REREI AFV ++ Sbjct: 159 FCRSEADWIVGVNGTRATTALRERKTQRREVSPVGRVQTPTLAMPVIREREIAAFVARDY 218 Query: 220 WEVDASTTTPSGEALALQVTHQNDKP-----------------FRPVNKEQTQAAVSLLE 262 WE+ + +G +A + + R +K + QA V + Sbjct: 219 WEIHGTFRAEAGTYVAKWIGDADGDTSPAETEGDAEAEAEQTGARCFDKAKAQAIVDKCK 278 Query: 263 KARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMR 321 S + E KP A F + LQ+ A+ R F KKT+ +AQ LYE TY R Sbjct: 279 GVDPSSVVDESKPEERPAPALFDLTALQREANKRFKFSAKKTLDIAQALYEKHKATTYPR 338 Query: 322 TDSTNLSQDAVNMVRGYIS-------DNFGKKYLPE---SPNQYASKENSQEAHEAIRPS 371 TDS L +D + ++ + ++ + P++ H AI P+ Sbjct: 339 TDSRALPEDYLETAAATLATFASTPLEAHAQRVIENGWVKPDKRIFNNADISDHFAIVPT 398 Query: 372 DVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRF 431 + + +D QK+Y L+ R+F+A AKY+ T T + G++L Sbjct: 399 G-----QQPDGLSSDEQKIYDLVSRRFIAVFHPSAKYEKTVRTTIVAGETFRTSGKVLVE 453 Query: 432 DGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK--- 488 GW V D L V G+A+T + TKPP R++EA+L+ +E Sbjct: 454 PGWLAVYGEKAHDDTAAALCKVADGEAVTADAIELKALQTKPPKRYTEATLLAAMENAGR 513 Query: 489 -------------RGIGRPSTYASIISTIQDRG---------YVRVENRRFYAEKMGEIV 526 GIGRP+T A+II + + Y+R ++ + Sbjct: 514 QVEDKDIRAAMKANGIGRPATRAAIIEGLLEDKDKNDNPKEPYLRRDDNELVPTPKAMEL 573 Query: 527 TDRLEENFRE-LMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEG 585 LEE + L++ T + E L ++ + + T ++ + Sbjct: 574 IAFLEEAGIDFLVSPQMTGEWEQKLLRMEKGDYRRSTFMSEIADLSTGMVETIRA--KYN 631 Query: 586 GMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNV 645 + CP CG + + G CSG L + Sbjct: 632 ELPEPVAKALDAPCPRCGAAVHV----DGRAYQCSGCDFKVWGEI-LGRRLTEAEASTLI 686 Query: 646 LEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKGYD 705 + + + ++ K A+ + K +E Sbjct: 687 ANRKTSVLSGFTSRTSGKKFSAALKLDVETGKVDF----------EFEDRAAPASNGEAK 736 Query: 706 GPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEK 765 +C KC S + ++ ACT C + P E + + Sbjct: 737 QLKAKCPKCSSGIEIQA----WNYACTG--CDFKVRTEIASRKLSPGEAETLIGKGKTGV 790 Query: 766 SDAYFVLRDGAA 777 + Sbjct: 791 LAGFVSKSKRKF 802 >UniRef50_C7HY28 DNA topoisomerase III n=1 Tax=Thiomonas intermedia K12 RepID=C7HY28_THIIN Length = 723 Score = 509 bits (1310), Expect = e-142, Method: Composition-based stats. Identities = 145/747 (19%), Positives = 259/747 (34%), Gaps = 92/747 (12%) Query: 5 LVIVESPAKAKTINKYLG-----SDYV--------VKSSVGHIRDLPTSGSAAKKSADST 51 L+I E P+ A+ I +G Y+ V GH+ + Sbjct: 3 LIIAEKPSVAQAIADVIGGVRRGDGYIDCPQAKTRVTWCFGHLLEQARPEDYVNGGKVLA 62 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPG-KEKVVSELKQLAEKADHIYLAT 110 P G K + ++ L + A + A Sbjct: 63 --------------------SHLPVIPTAWKLAPRDGGAGKQIKAIRDLLKDATEVVNAG 102 Query: 111 DLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELN--IDRVNAQQAR 168 D DREG+ + + + R+ + + ++R+A + + AR Sbjct: 103 DADREGQLLVDEVLLFLNWKGKTT-RLWLSSLDDESVRRALVTVKSNDALRPLYESALAR 161 Query: 169 RFMDRVVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVD 223 + D ++G S L + + S GRVQ+ + L+V+R+R+I+ F P + ++V Sbjct: 162 QRADWLMGMNASIALSRNLQACGVQGAWSVGRVQTPTLALLVDRQRDIQNFKPRDHYQVQ 221 Query: 224 ASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAP 283 A+ + Q D ++K + ++ R +V K + P Sbjct: 222 ATLDGDIRALWQIPEDLQTDD-GLLLDKSAAETCAQAVQGQRATVAAFTRKAGERQAPMP 280 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNF 343 + STLQ+ AS+RLG K T+ AQ LYEA TY R+D L + I Sbjct: 281 YALSTLQKTASSRLGLSAKDTLAAAQELYEAKLATYPRSDCPWLPVEMHAAAAQIIRALG 340 Query: 344 GKKY--LPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVAC 401 + + A EAH I P+ + + + +A+K+Y L+ ++ Sbjct: 341 AAEMAGIDPERRHPAWNTAKVEAHHGIIPTGRGL--AEVSGLSENAKKIYGLLRESYLRL 398 Query: 402 QMTPAKYDSTTLTVGA-GDFRLKARGRILRFDGWTKVMPALRKGDEDRI-----LPAVNK 455 M P +++ G R KA RI++ GWT++ A ++D LP + + Sbjct: 399 FMPPETFETREALFTFPGAERFKASARIVQESGWTQLGQADNSAEDDETGQVARLPILTE 458 Query: 456 GDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYA 498 G L T PP +++ +L+ + E G+G +T A Sbjct: 459 GQQLACESAQVLAKRTSPPKPYTDGTLIAAMTGVHKLVTDPKLKARLKETSGLGTEATRA 518 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 S+I + R Y + + + + G + D L + +L + TA E++L +A+ + Sbjct: 519 SMIEVLIAREYAERKKKEIHPTERGVQLIDMLRKVAPDLADPGTTALQEDALAAIASARS 578 Query: 559 EWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKM-GIRTASTG--- 614 + + + K G + CP CG RT+ G Sbjct: 579 TFDEFMTAQIDAVRESTQKL------LGGQLGATPAILHACPACGGGRCAQRTSKAGATY 632 Query: 615 -VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYL 673 L C + P + + E A A + +C C Sbjct: 633 HRCLDCDAAFGDDGGK--------PGKRFEDKHQSEGAAAKAPASGPKCLSCKKPTFKNE 684 Query: 674 IDPKRKLHVCGNNPTCDGYEIEEGEFR 700 + + CG C G + + Sbjct: 685 TKTGKPYYRCGG---CKGAWWPDRKDE 708 >UniRef50_A0CUH3 Chromosome undetermined scaffold_28, whole genome shotgun sequence n=3 Tax=Paramecium tetraurelia RepID=A0CUH3_PARTE Length = 947 Score = 508 bits (1308), Expect = e-142, Method: Composition-based stats. Identities = 151/872 (17%), Positives = 305/872 (34%), Gaps = 83/872 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVK---SSVGHIRDLPTSGSAAKKSADSTSTKTAKKP 59 K L + E P+ A++I L D+ V+ S + ++ ++ T Sbjct: 14 KVLNVAEKPSVARSIANVLARDHTVEETQSPYNKLFKFNFK-FGDQEVEMWITSVTGHLK 72 Query: 60 KKDERGALVNRMGVDPWH-NWEAHYE-VLPGKEKVVS-ELKQLAEKADHIYLATDLDREG 116 DP +A E ++P +++ + LKQ A + + L D DREG Sbjct: 73 SLRYPKQYQKWDQWDPIIILKDAEIENIIPNEKRFLEGNLKQFARECSQLILWLDCDREG 132 Query: 117 EAIAWHLREVIGGDDARYS--RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 E IA+ + EV + + R F+ +T I++A + + + + N+ AR+ +D Sbjct: 133 ENIAFEVLEVCKDSNPQIQVHRAHFSAVTYIDIKKALDNLKQPDENLSNSVLARQEIDLR 192 Query: 175 VGYMVSPLLWKKIAR------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 +G + + + +S G Q + VV+R++EI +FV E+FW + T Sbjct: 193 IGASFTRFQTLLLQQQFHLQSVISYGPCQIPTLGFVVQRQKEIDSFVKEKFWFIQCEDQT 252 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 G N ++ + + + + K P T Sbjct: 253 KCG---------YNWSRGNIFDEMIVLILFERCFTEQAKITDVQSKEVQKWKPYPLSTIE 303 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVNMVRGYI----SDN 342 ++ AS +L K M +A++LY G+I+Y RT++ + N++R + Sbjct: 304 FEKLASKKLKISAHKAMELAEKLYNRGFISYPRTETNKFPPTINLQNIIRDQVNHPVWGE 363 Query: 343 FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQ 402 F + + + +Q + +AH I P + +++ ++YQLI R F+AC Sbjct: 364 FAQSLINCNFDQPRAGNKDDKAHPPIHPVKMMRESDAQ---TQQEWEIYQLITRHFLACC 420 Query: 403 MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLV 462 AK TT+ + + +G ++ + ++ P +P KGD + + Sbjct: 421 SKNAKGSETTVNLQVQEESFYKQGLVILEKNYLEIYPYDEW--SQSQVPNYKKGDMIQIT 478 Query: 463 ELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKM 522 L T PP +E+ L+ ++K GIG +T I+TIQ+R Y + + K+ Sbjct: 479 -LKIQNGKTSPPKPMTESELIGLMDKNGIGTDATIHEHINTIQEREYAIKKGQIIKPTKL 537 Query: 523 GEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDP 582 G + + E L A ME +++VA + K +++ ++ + L + ++ Sbjct: 538 GLALVESYEMLGFTLHKPHLRAVMEQRMNEVAQGTKQKKQIVEATIAEMSDILKQLQEKR 597 Query: 583 EEGGMRPNQMVLT-------------SIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 + Q + T + + +++ Sbjct: 598 SQIISTFGQYLEALKDYDENNDDDNTQNRDLTQQNQQKQKKNKIPKKQQQYQQQQQQQQQ 657 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 + + + + + + + C CGT + L +C C Sbjct: 658 QQQQQQQQQQQQQQQQQQQQQQQVYQQNYSQFCNICGTQLVEIKQINGTFLEICLKC--C 715 Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVA 749 G E + I+ Y M F N +K ++ Sbjct: 716 LGQEKSQNFNSIQNYQPQSQNYNS--------MSNFQPKSQ-NNNTSNFQQKFFKSSNFE 766 Query: 750 PPKEDPVPLPELPCEKSDAYFVLRDG--AAGVFLAANTFPKSRETRAPLVEELYRFRDRL 807 + C + +R F +P+ L Sbjct: 767 ETFK---------CNQCQNQMKIRQSKLKNSYFFGCLGYPQCN------------QAIFL 805 Query: 808 PEKLRYLADAPQQDPEGNKTMVRFSRKTKQQY 839 P+ ++ + ++ + N + + + Sbjct: 806 PDYIKSIQRTDKKCRKCNSNIFQTEYSENSTF 837 >UniRef50_B4RLM8 TopB n=9 Tax=Neisseria RepID=B4RLM8_NEIG2 Length = 679 Score = 508 bits (1307), Expect = e-142, Method: Composition-based stats. Identities = 161/706 (22%), Positives = 271/706 (38%), Gaps = 102/706 (14%) Query: 5 LVIVESPAKAKTINKYLG------------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 L + E P++AK I K LG D +V + GHI + ++ AD Sbjct: 3 LFLCEKPSQAKDIGKVLGVLGGRHDGYFQNGDTIVTWAFGHILTQAAPDAYGEQYAD--- 59 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P +V P K +K L KAD + +ATD Sbjct: 60 ---------------FGNISALPILPEVWQMQVPPKVSKQFKVIKSLLAKADEVVIATDA 104 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQARRF 170 DREGE IA + + G + SR + + ++++A + PG+ + A AR Sbjct: 105 DREGEVIAREILDYCG-YRKKISRFWTSGLDTQSVKKALSSIMPGKDKENLYQAGLARGR 163 Query: 171 MDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 D +VG +S + G LS GR+Q+ ++LVV+R++EI FVP ++ + Sbjct: 164 ADWLVGMNLSRAYTAAYSAGYGREHILSIGRIQTPTLKLVVQRDKEIDTFVPYNYYTLSV 223 Query: 225 STTTPSGEALALQV---THQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPG 281 T + + N E +A V LEK+ V+ + ++ P Sbjct: 224 DFETADKSVFTTLWQVPENWRNTDGYCTNLEAVKALVKQLEKSTGKVITSNKERKSTPPP 283 Query: 282 APFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT-YMRTDSTNLSQDAVNMVRGY-- 338 P+ S LQ+ A +LG K + +AQ LYE IT Y RT L + ++ V+ Sbjct: 284 LPYSLSALQKEAGKKLGLSASKVLKIAQTLYEKYKITSYPRTPCRYLPKSQMSEVKDVFA 343 Query: 339 ----ISDNFGKKYLPESPNQYASKENS----QEAHEAIRPSDVNVMAESLKDMEADAQKL 390 I + P + + N + +H AI P+ + L ++ + + Sbjct: 344 AIQTIDKSMLSVIEKADPERQSRVWNDNQVNKHSHHAIIPTKASNF--DLSVLDKNELTV 401 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKG----DE 446 Y++I +++A +YDST + V A KA + GW ++ DE Sbjct: 402 YRMIRDRYIAQFYPDFEYDSTVVEVEACSHLFKASSQSPVISGWKVLLGKDVFEGDQIDE 461 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE------------------- 487 LP + D + + P T PP RF+EASL+ E++ Sbjct: 462 GPALPHLKVNDEVDTLSFNPETKKTTPPPRFTEASLLDEMQTLKDFLKNVEDEQIRKILK 521 Query: 488 -KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546 G+G +T A+II + + GY+ + + YA + G + R+ + + TA+ Sbjct: 522 STEGLGTEATRATIIDRLFEMGYMEKKRSKIYATEKGRNLIARIPTM---IADPITTAKW 578 Query: 547 ENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID-------- 598 E +L + + + + T+ + +A+KD P Q Sbjct: 579 ELALAGIEAGKLTLAEFMAYQQKVITELVGQAKKDAVGKARPPKQTDSAGTKKQAVARNE 638 Query: 599 ---CPTCGRKMGIRTA----STGVFLGCSGYALPPKERCKTTINLV 637 CPTC + + GCS + CK + Sbjct: 639 DDVCPTCKEGRLRQRGFKENPDKRYWGCSRFP-----ECKHFEWVK 679 >UniRef50_C6BT42 DNA topoisomerase type IA central domain protein n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BT42_DESAD Length = 720 Score = 507 bits (1306), Expect = e-142, Method: Composition-based stats. Identities = 157/755 (20%), Positives = 273/755 (36%), Gaps = 100/755 (13%) Query: 5 LVIVESPAKAKTINKYLG------------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 L I E A I++ LG + + GH+ L ++ Sbjct: 3 LFIAEKRDVALAISQALGGPDRPTGAAFQVNGDRITWLWGHVLRLTDPEEHDERYKLWDL 62 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 K W Y + ++ +LA +AD + A D Sbjct: 63 NTLPMK--------------------WPVTYAPESKHVDHLKKIIELAHQADELVNAGDP 102 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQARRF 170 D EG+ + + E G + R++ N+ +AI +A + AR Sbjct: 103 DPEGQRLVDEVIEFAGLLEKPTKRLLINDNNGSAILKALKNMENNSKYHGLSMSALARAV 162 Query: 171 MDRVVGYMVSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 D+ GY ++ K LS GRVQ+ + LVV R+R + + + V A Sbjct: 163 CDQRYGYNLTRCYSTLAQKKGYQGVLSVGRVQTPILGLVVARDRAHEGHEKQAYHTVKAQ 222 Query: 226 TTTPSGEALALQVTHQN---DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 PS A + + D+ R + + + ++ +VL + + P Sbjct: 223 IDMPSQLVEAEYIPADDAPVDEKGRIADAVFGKKIANEVQGQPATVLSVQTSERKNDPPL 282 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISD 341 P+ LQ A+ + KK + + QRL + ITY R+D L+ + + Sbjct: 283 PYNLLALQADAAGLWNYKPKKVLEITQRLRDQHKAITYNRSDCRYLNDERHAEAPELLQA 342 Query: 342 N---FGK--KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWR 396 FG +Y + A AH AI P+ + L + D +++Y LI + Sbjct: 343 LTPAFGDMAEYAAPNLKSKAFNSKKVTAHHAIIPT---MNVPELGKLNEDERRIYTLIVK 399 Query: 397 QFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKV----MPALRKGDEDRILPA 452 ++A PA++ +T + + + KA GR+ GW + + K ++ L Sbjct: 400 LYIAQFYLPAEFVATKVELKIAGHKFKAEGRLNSSPGWRLLDEQYLKDYEKAEKQPELHK 459 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-------------------------E 487 + + D+ T+ + FTKPPAR++ SL+K+L E Sbjct: 460 LQQNDSGTVESAESVKSFTKPPARYTMKSLLKDLTSVAKYVTDPEIKKLFMDKDSDKQDE 519 Query: 488 KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQME 547 GIG P+T S I T+ RG+V ++++ + ++G D L E + D TA Sbjct: 520 SGGIGTPATRDSHIETLFRRGFVAEKSKKVISTELGREFHDALPEFA---VKPDMTALWH 576 Query: 548 NSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMG 607 Q+ E + +++ Q++ + ++ + +++ CP C Sbjct: 577 EKQKQIEAGELNYLQLIEEVDGSVAQEIARVKR-------EGINIKSSAVQCPKCKTGFL 629 Query: 608 I-RTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG 666 R G F GCS Y C T P L+ + A+ A + +CP CG Sbjct: 630 KPRKGPKGKFWGCSAYP-----DCNATF---PNKAGKPDLKAKPAKKLAASKEHKCPDCG 681 Query: 667 TAMDSYLIDPKRKL-HVCGNNPTCDGYEIEEGEFR 700 + K C P C +E Sbjct: 682 KGLIRRPAKRKGLFWWSCSGFPECKFRCFDEKGKP 716 Score = 66.3 bits (160), Expect = 5e-09, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 27/88 (30%), Gaps = 6/88 (6%) Query: 710 ECEKCG-SEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVP--LPELPCEK 765 +C KC + + G GK+ C+ +C T K E C Sbjct: 620 QCPKCKTGFLKPRKGPKGKFWGCSAYPDCNATFPNKAGKPDLKAKPAKKLAASKEHKCPD 679 Query: 766 SDAYFVLRDGAAG--VFLAANTFPKSRE 791 + R + + + FP+ + Sbjct: 680 CGKGLIRRPAKRKGLFWWSCSGFPECKF 707 Score = 53.2 bits (126), Expect = 5e-05, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 32/102 (31%), Gaps = 6/102 (5%) Query: 744 RNGEVAPPKEDPVPLPELPCEKSDAYFVL-RDGAAGVFLAANTFPKSRETRAPLVEELYR 802 + + + + C K F+ R G G F + +P A + + Sbjct: 602 QEIARVKREGINIKSSAVQCPKCKTGFLKPRKGPKGKFWGCSAYPDCN---ATFPNKAGK 658 Query: 803 FRDRLPEKLRYLADAPQQDPEGNKTMVRF--SRKTKQQYVSS 842 + + A + P+ K ++R RK + S Sbjct: 659 PDLKAKPAKKLAASKEHKCPDCGKGLIRRPAKRKGLFWWSCS 700 >UniRef50_C0FPK2 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=C0FPK2_9FIRM Length = 680 Score = 507 bits (1306), Expect = e-142, Method: Composition-based stats. Identities = 144/693 (20%), Positives = 247/693 (35%), Gaps = 84/693 (12%) Query: 5 LVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTST 53 LVI E P+ A++I LG Y+V GH+ +L + A T Sbjct: 3 LVIAEKPSVAQSIAAVLGAKSRHDGYLEGGGYIVSWCFGHLAELADAAVYNAVDAKWTLA 62 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLATD 111 P + V K+K L++L + D + A D Sbjct: 63 ALPIIPT-------------------SFRFIVRSEKQKQFDILRELVRREDVAEVVNACD 103 Query: 112 LDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPG--ELNIDRVNAQQARR 169 REGE I + + G R+ + + +AIR F + + R Sbjct: 104 AGREGELIFRTVYCLAGCS-KPILRLWISSMEDDAIRSGFQQLRSGRDYDGLHQSALCRA 162 Query: 170 FMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 D +VG + R L+ GRV S + L+V+RE EI AFV E F+ V P Sbjct: 163 KADWLVGINATRYFSLMYGRTLNIGRVMSPTLALLVQREAEISAFVAEPFYTVQLDCGFP 222 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTL 289 + R +++ A + + +V E K + K A + ++L Sbjct: 223 ATTD-------------RMKDRKDADAIANACKGKTVTVKSVERKEKSEKAPALYDLTSL 269 Query: 290 QQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLP 349 Q+ A+ LG+ ++T+ Q LYE TY RTDS L+ D V G ++ + Sbjct: 270 QRDANRVLGYTSQQTLDYLQALYEKKLCTYPRTDSHYLTDDMEGSVPGLVAAAAAACGVE 329 Query: 350 ESPNQYAS---KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPA 406 + P A H AI P+ ++ + + +++ +L + + P Sbjct: 330 KPPTICAKQVCSSKKVTDHHAIVPT-ISAEKVDMASLPLGEREVLKLAAKGLLRAVDEPH 388 Query: 407 KYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTP 466 +Y T +TV A+G+ + GW + + + LP + L++ + Sbjct: 389 RYAETVITVDCAGQSFTAKGKTVLAPGWKRY--EQEQTEAVPALPVATENQTLSVSAASV 446 Query: 467 AQHFTKPPARFSEASLVKEL------------EKRGIGRPSTYASIISTIQDRGYVRVEN 514 T PP F+E +L+ + E++GIG P+T + II + G+V Sbjct: 447 KTGKTTPPKHFTEDTLLAAMENAGKEDMPDDAERKGIGTPATRSGIIEKLVSSGFVERRK 506 Query: 515 RR----FYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 + G + L E +L + TA+ E+ L ++ E + +D + Sbjct: 507 SKKITNLLPTSTGTALITVLPE---QLQSPQLTAEWEHRLKEIERGEIAPDSFMDGIAAM 563 Query: 571 FTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERC 630 + + + K + CP CG ++ + G F C C Sbjct: 564 LNELV-QTYKPIPGAEVLFPSGREVVGKCPRCGAEVT--ESQKGFF--CEN------RSC 612 Query: 631 KTTINLVPENEVLNVLEGEDAETNALRAKRRCP 663 + + AL R P Sbjct: 613 AFVLWKNSRFFAAKKKALTKSLAAALLKNGRAP 645 >UniRef50_A4YF11 DNA topoisomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YF11_METS5 Length = 681 Score = 507 bits (1306), Expect = e-142, Method: Composition-based stats. Identities = 158/700 (22%), Positives = 288/700 (41%), Gaps = 84/700 (12%) Query: 4 ALVIVESPAKAKTINKYLGSD-----------YVVKSSVGHIRDLPTSGSAAKKSADSTS 52 LVI E P+ A I + LG Y+V + GH+ + Sbjct: 2 KLVITEKPSVALDIARALGKPTRRQGYLEVGEYLVTWTYGHLLE---------------- 45 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 E + P + Y+++ GKE +++L E AD + D Sbjct: 46 --------IGEIAPKRWNLKDLPIFPEKFEYDLIKGKESQFKVVRKLLEGADAVINCGDA 97 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNE-ITKNAIRQAFNKPGE--LNIDRVNAQQARR 169 REGE I L E G + R+ +E +T++ + + + + AR+ Sbjct: 98 GREGELIVRELLEFTG-YRGKVLRLWTSEALTRDVVLRELRRLRPSSEFDSLYYSALARQ 156 Query: 170 FMDRVVGYMVSPLLWKKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 D +VG ++ L+ K G S GRVQ+ + ++V+R+REI+AF PE ++ V A Sbjct: 157 NGDWIVGINLTRLVTLKAGGGEVWSVGRVQTPTLAMIVKRDREIEAFKPEIYYVVLAGFE 216 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFIT 286 V +N + R +E+ + V+ L+ R V + + + +P Sbjct: 217 GE-----MKGVMLRNGEEARLA-REEAEQVVNALKSVRSGRVEKVDVERREERPPLLHSL 270 Query: 287 STLQQAASTRLGFGVKKTMMMAQRLYE-AGYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 ++LQ+ A+T G K+T+ +AQ LYE I+Y RTD+ L + ++V+ + Sbjct: 271 TSLQREANTLYGLSAKRTLDVAQSLYEEWKLISYPRTDARYLGEGNRDLVKDVLRKLGRG 330 Query: 346 KYLPESPN--QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQM 403 + +P + + H AI P D +++ A +K+Y L++R+FV M Sbjct: 331 ELVPRVDRVGKRVFDSSKLTDHHAIIPLDRPP-----ENLPAIHRKVYDLVYRKFVGAFM 385 Query: 404 TPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVE 463 Y+ + + G+ GW ++ P D +P+ G+ + Sbjct: 386 DDYVYELQRVFIRLDGELFLVEGKRNLQLGWMELYPH---EDNPLKIPS---GE-VRKEW 438 Query: 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMG 523 + + TKPPARF+EASL++E+E+ G+G P+T A II T+ +RGYV + Y+ G Sbjct: 439 VKAEERQTKPPARFTEASLLREMERLGLGTPATRAGIIETLLERGYVERRGKSLYSTDKG 498 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQVA---NHEAEWKAVLDHFFSDFTQQLDKAEK 580 + D+L + ++++ D TA+ E L+++ E ++ ++ +++++ K Sbjct: 499 RELVDKLGD--SKVVSPDMTAEWERQLEEIYVKRLGEKGYQEFMEGIRRFTREEVERLMK 556 Query: 581 DPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEN 640 E + R +G++ TG+ + L Sbjct: 557 --REFKVERRATPEMLRLARAVSRDLGVKLEGTGME--------------EVKRFLDENL 600 Query: 641 EVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL 680 + + E +C KCGT + + K Sbjct: 601 PKMRITCKCGGEVVGFSRGWKCRKCGTVVWREIAGKKITF 640 >UniRef50_B3DUF7 DNA topoisomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DUF7_METI4 Length = 855 Score = 507 bits (1305), Expect = e-142, Method: Composition-based stats. Identities = 173/809 (21%), Positives = 301/809 (37%), Gaps = 115/809 (14%) Query: 1 MGKALVIVESPAKAKTINKYLG------------SDYVVKSSVGHIRDLPTSGSAAKKSA 48 MGK LVI E P+ A+ I + LG ++ S+VGH+ +L + Sbjct: 1 MGKTLVIAEKPSVAQDIAEALGGFPKGRKDIYENDRMIISSAVGHVVELCLPAEMDSRHR 60 Query: 49 DSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYL 108 + + P + H E D I Sbjct: 61 QWSLSNLPILPSSFSLKPIQKHKDRLNLLLSLLHRE-----------------DVDLIIN 103 Query: 109 ATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI--DRVNAQQ 166 A D REGE + +L + R+ +TK+AI +AF L A Sbjct: 104 ACDAGREGELVFRYLIRFA-QVNKPIQRLWLQSMTKDAIIEAFKNLRPLREVEGLACAAV 162 Query: 167 ARRFMDRVVGYMVSPLLW-----KKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWE 221 +R D ++G + L K R S GRVQ+ + LVVER++EI +F P+ +WE Sbjct: 163 SRSESDWLIGINGTRALTALHSNSKGFRLTSVGRVQTPTLALVVERDKEILSFQPKPYWE 222 Query: 222 VDASTTTPSGEALALQVTH------QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKP 275 + A+ + GE A + +++ P R N++Q Q+ + V E E K Sbjct: 223 ILATFRSKQGEYKAKWFSRNSQHEGEDNHPERIENEDQCQSIIEKCLNKEGIVTE-EKKV 281 Query: 276 TTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNM 334 + P + ++LQ+ A+ R GF ++T+ + Q LYE ITY RTDS L +D V Sbjct: 282 SQQSPPLLYDLTSLQREANNRFGFSAQRTLQIVQSLYENHKLITYPRTDSKFLPEDYVPR 341 Query: 335 VRGYISDN-------FGKKYLPESPNQYASK---ENSQEAHEAIRPSDVNVMAESLKDME 384 V+ + + F ++ L ++ Q A+K H AI P+ + Sbjct: 342 VKEVLKNLSHGPFETFAREILSQNWVQPANKIFNNQKVSDHFAIIPTTHKPT-----TLN 396 Query: 385 ADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRK- 443 A+ +K+YQLI R+F+A PA+++ T + + G+IL+ GW KV Sbjct: 397 ANEEKIYQLIVRRFLATFYPPAQWEITKRITVVEEESFRTEGKILKSAGWLKVYRDSNPA 456 Query: 444 -GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE--------------- 487 E+ +L + +G+ + + + TKPPA F+EA+L+ +E Sbjct: 457 QNTEEDVLCPIEQGEKVLNLAMEKIAKETKPPAHFTEATLLSAMESAGKLVEDETLREAM 516 Query: 488 -KRGIGRPSTYASIISTIQDRGYVRV-ENRRFYAEKMGEIVTDRLEEN-FRELMNYDFTA 544 K+G+G P+T A II + + GY+R + + A + + L + L + + T Sbjct: 517 AKKGLGTPATRAGIIEGLIEDGYIRRQDGKALVATPKAFALIELLSAAQIQTLRSAELTG 576 Query: 545 QMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKA-------------------------- 578 + E L + + + ++ + +DKA Sbjct: 577 EWEFKLQMMEKEKYSQEKFMEEIYQLTASIVDKAKALGSIANVKKALPLFTPQGKAIEET 636 Query: 579 -EKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGV---FLGCSGYALPPKERCKTTI 634 + G + + I + G F G + + Sbjct: 637 LYEYQAPDGSFHVNKYIAGRPLFPDELEKLISQRTIGPLKGFYNKKGQPFTATLKLEDER 696 Query: 635 NLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEI 694 + + +GED + + + CP + + ++ + C N + Sbjct: 697 GTLRFEFEKDESQGEDKQILSEESLGSCPIDNSPVL-----EAKEYYACLNYFSDQNSHK 751 Query: 695 EEGEFRIKGYDGPIVECEKCGSEMHLKMG 723 + K + I E + K Sbjct: 752 CPFKVNKKILEQEISREEMKKLLLEKKTS 780 >UniRef50_D0NZ98 DNA topoisomerase, putative n=1 Tax=Phytophthora infestans T30-4 RepID=D0NZ98_PHYIN Length = 907 Score = 506 bits (1304), Expect = e-141, Method: Composition-based stats. Identities = 154/850 (18%), Positives = 277/850 (32%), Gaps = 82/850 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDY------VVKSSVGHIRDLPTSGSAAKKSADSTSTKTA 56 K L + E P+ AK I L S S + + P + ++ T Sbjct: 2 KVLNVAEKPSVAKEIANILSSGRSHRVCRAGFSKYNALFEFPYQVRGQQV-QMVVTSVTG 60 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHYEV----LPGKEKVVSELKQLAEKADHIYLATDL 112 + D ++ + DP + A ++K+ L + A+ + + L D Sbjct: 61 HIMELDFDASVRSWHSCDPVDLFTAPVTKKIRSDETQKKIEKTLMEEAKHSQWLVLWLDC 120 Query: 113 DREGEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRF 170 DREGE IA+ ++ + ++R R F+ + I A + N A AR Sbjct: 121 DREGENIAYEVKSICEKTNSRLRVFRARFSALIPRDIVHAVQNLSQPNEKLSLAVDARSE 180 Query: 171 MDRVVGYMVSPLLWKKI----------ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 +D +G + +I +S G Q + VVER +I+ F E F+ Sbjct: 181 IDLRIGAAFTRFQTMRIQSRFPALNQEKNVISYGPCQFPTLGFVVERFLKIRNFEREAFY 240 Query: 221 EVDASTT-TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSK 279 + + T +A + F + SL+E ++ + +P+ + Sbjct: 241 YISVTHQQTDQPDAPTTTFKWKRGHFFDRMACLCI--YESLVESQTAAIESVDKRPSWKR 298 Query: 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVNMVRG 337 P T LQ+ AS L + TM A+ LY G I+Y RT+++ + D +++VR Sbjct: 299 KPLPLTTVELQKRASRWLRISSEATMKAAESLYNKGLISYPRTETSKFKEGTDLMSLVRA 358 Query: 338 YISDNFGKKYLPE------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDM-EADAQKL 390 + + Y+ + +AH I P+ L + + D +K+ Sbjct: 359 HETHQQWGNYVTRQLLDGGKYEAPRHGNSDDQAHPPIHPTKSV----DLNTLPDPDEKKV 414 Query: 391 YQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRIL 450 Y+ + F+AC AK T++ + + R A G ++ + + + + Sbjct: 415 YEFVSLHFLACCSRDAKGSQTSVVMAMLNERFIASGLMVEERNYLDIYKYEKWNA--SAI 472 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 P GD L T PP SEA L+ +++ GIG +T A I TI R Y Sbjct: 473 PVYKHGDVFRPSTLVMLSGDTNPPPLLSEADLIAKMDSNGIGTDATIAEHIKTILKREYA 532 Query: 511 RVENR--RFYAEKMGEIVTDRLEENFRELMNYDFTA----QMENSLDQVANHEAEWKAVL 564 N +F +G + E EL A MEN ++ + + V+ Sbjct: 533 IKVNNETQFKPTTLGLALVLSYEHMGLELAKPVLRAAVSLIMENDCKAISLGQKALRQVV 592 Query: 565 DHFFSDFTQQLDKAEKD----PEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCS 620 D + + + + + Q V + D R + Sbjct: 593 DSCMAQMKGIFLEVTRSATVLDQTFSEQFGQPVYDTADFRMPPRGEARPRTPVDI---EP 649 Query: 621 GYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDP---- 676 + + + R + + P + + RC G + Sbjct: 650 RHVIRDRRRKRQRLPSRPTDNSAQAQRRILRAPSLTSDIPRCDDHGLPCVEKEVTRDGPN 709 Query: 677 -KRKLHVCGN--NPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG--KYMAC 731 R + C CD + E C K G ++ C Sbjct: 710 TGRMFYKCSLPQGEQCDFFAWVSDSNAPIVKCP--GHNEPCAERTVKKDGPNKGRQFYIC 767 Query: 732 ----TNEECKNTRKILR-------NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGA---- 776 T+ C + + + + D C + +R Sbjct: 768 RRGQTDNSCGFFLWKDEVTDTPSGSAQASAARGDAGTSSAPKCSGHNTLCAVRKTRKPGP 827 Query: 777 --AGVFLAAN 784 F A + Sbjct: 828 NQYREFYACS 837 >UniRef50_Q9JN65 DNA topoisomerase 1 n=2 Tax=Mycoplasma gallisepticum RepID=TOP1_MYCGA Length = 719 Score = 506 bits (1303), Expect = e-141, Method: Composition-based stats. Identities = 221/736 (30%), Positives = 338/736 (45%), Gaps = 68/736 (9%) Query: 2 GKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKK 61 K LVI ESP K KTI KYL DY + ++VGHIRDLP PK Sbjct: 6 SKILVI-ESPNKVKTIKKYLTDDYEIVATVGHIRDLPK--------YTLGFNTEDFVPKW 56 Query: 62 DERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + GV + + + K++++ EL A+KAD IYLATD DREGEAI+W Sbjct: 57 EIIQEKKPAKGVSATKKAKTVKKAVKNKKEIIDELVDKAKKADEIYLATDPDREGEAISW 116 Query: 122 HLREVIGGDDARY---SRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYM 178 H+ +V+ R++FNEI++ A++ A P E+ D V++Q RR +DR++G+ Sbjct: 117 HVYDVLKEKGVNVNKCKRIIFNEISEKAVKNAIANPREIQKDWVSSQITRRRLDRLIGFK 176 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQV 238 +S L+ KI SAGRVQS+A++ + ERE I FVP +W +D + L Sbjct: 177 LSSLMKSKINAD-SAGRVQSIALKFITEREELINKFVPRFWWTLDVILKDGTELMLRKID 235 Query: 239 THQNDKPF----------RPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 DK KE + L K +S P + TST Sbjct: 236 EKLKDKLGFKELEEVSGIDFNTKEDAELVKQHLSDKYRVYAIDTPKLKSSYPKEVYKTST 295 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEA--------GYITYMRTDSTNLSQDAVNMVRGYIS 340 LQQ A +L + K +AQ LYE I+Y RTDST LS + V +++ Sbjct: 296 LQQDAINKLKWRSMKITSVAQELYEGVTIDDEQIALISYPRTDSTRLSPEYGKTVLDFVA 355 Query: 341 DNFGKKYL-------PESPNQYASKENSQEAHEAIRPSDVNVMAESLKD-MEADAQKLYQ 392 +GK Y+ E+ K Q+AHEAI P D+++ +S+K+ + +D LY+ Sbjct: 356 KTYGKDYVATQSQLNGETKANKKQKAKVQDAHEAIHPIDISITPDSVKNKISSDQYSLYK 415 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD--EDRIL 450 LIW + VA M A Y+ + + + A L+FDG+ K+ D L Sbjct: 416 LIWTRTVAHYMAAAVYELVNIRFINNNNKFYAVNNTLKFDGYKKIYTHYDDKDHLRKLDL 475 Query: 451 PAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYV 510 ++ +H TKPPARF++A+L++ LE GIGRPSTY++I+ + R Y Sbjct: 476 NHFAIDKEFEAKDVLLNEHQTKPPARFTQATLIEALETEGIGRPSTYSTILDIVLKRNYA 535 Query: 511 R-VENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFS 569 V R + +G+ + L++NF ++N +FT ME +LD++A + L F++ Sbjct: 536 ELVNGRYYKTTDLGQKLAFELDKNFPTIINKEFTKNMETTLDEIAQGTVNDVSYLQAFWN 595 Query: 570 DFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKER 629 DF++ L++A+ + + +CP C ++ R G F+GCS + + Sbjct: 596 DFSEVLNEAKTNIVKKVEYI-----EGKNCPNCSSQLVRREGRYGPFVGCSNFP-----K 645 Query: 630 CKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR-----KLHVCG 684 CK + + + EG +C C + + K C Sbjct: 646 CKFIEKSEQKAKEIVYEEG-----------VKCELCHAKLIRRVAKKKGRNKDNTFLGCS 694 Query: 685 NNPTCDGYEIEEGEFR 700 N P C + E E Sbjct: 695 NFPKCKYTKSLEPEKD 710 Score = 77.8 bits (190), Expect = 2e-12, Method: Composition-based stats. Identities = 25/109 (22%), Positives = 43/109 (39%), Gaps = 13/109 (11%) Query: 704 YDGPIVECEKCGSEMHLKMGRFGKYMACTN-EECKNTRKILRNGEVAPPKEDPVPLPELP 762 C C S++ + GR+G ++ C+N +CK K + ++ V + Sbjct: 613 EYIEGKNCPNCSSQLVRREGRYGPFVGCSNFPKCKFIEKSEQKA------KEIVYEEGVK 666 Query: 763 CEKSDAYFVLRDGAAG------VFLAANTFPKSRETRAPLVEELYRFRD 805 CE A + R FL + FPK + T++ E+ RD Sbjct: 667 CELCHAKLIRRVAKKKGRNKDNTFLGCSNFPKCKYTKSLEPEKDETIRD 715 Score = 58.2 bits (139), Expect = 1e-06, Method: Composition-based stats. Identities = 18/103 (17%), Positives = 30/103 (29%), Gaps = 5/103 (4%) Query: 745 NGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELY--- 801 N + + C + V R+G G F+ + FPK + + Sbjct: 602 NEAKTNIVKKVEYIEGKNCPNCSSQLVRREGRYGPFVGCSNFPKCKFIEKSEQKAKEIVY 661 Query: 802 RFRDRLPEKLRYLADAPQQDPEGNK--TMVRFSRKTKQQYVSS 842 + L + NK T + S K +Y S Sbjct: 662 EEGVKCELCHAKLIRRVAKKKGRNKDNTFLGCSNFPKCKYTKS 704 Score = 53.6 bits (127), Expect = 4e-05, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 44/121 (36%), Gaps = 9/121 (7%) Query: 641 EVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFR 700 EVLN + + + CP C + + C N P C E E + + Sbjct: 599 EVLNEAKTNIVKKVEYIEGKNCPNCSSQLVRRE-GRYGPFVGCSNFPKCKFIEKSEQKAK 657 Query: 701 IKGYDGPIVECEKCGSEMH----LKMGRF--GKYMACTN-EECKNTRKILRNGEVAPPKE 753 + V+CE C +++ K GR ++ C+N +CK T+ + + Sbjct: 658 -EIVYEEGVKCELCHAKLIRRVAKKKGRNKDNTFLGCSNFPKCKYTKSLEPEKDETIRDS 716 Query: 754 D 754 Sbjct: 717 T 717 >UniRef50_B6KEM8 DNA topoisomerase n=2 Tax=Toxoplasma gondii RepID=B6KEM8_TOXGO Length = 677 Score = 506 bits (1303), Expect = e-141, Method: Composition-based stats. Identities = 142/648 (21%), Positives = 241/648 (37%), Gaps = 42/648 (6%) Query: 3 KALVIVESPAKAKTINKYLGSDYV---VKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKP 59 L + E P+ AK ++ L Y +S + S + ++ Sbjct: 7 TVLNVAEKPSVAKEASRLLSGGYQNAPTQSRFNPVHQFEFSLQ-NRSCTMLFTSVRGHLM 65 Query: 60 KKDERGALVNRMGVDPWHNWEAHYE--VLPGKEKVVSELKQLAEKADHIYLATDLDREGE 117 D A N + P + A E + V L LA KA + L D DREGE Sbjct: 66 SLDFASAYQNWNTIPPEDLYGAPVEKNISQDAGDVRKNLVDLARKAQWLVLWLDCDREGE 125 Query: 118 AIAWHLREVIGGDDA--RYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 IA+ + V +A R VF+ +TK + +A + ++ +A R +D + Sbjct: 126 NIAFEVLSVCREANASLNVFRAVFSALTKADLERACRTLQAPDRNQSDAVDTRSEIDLRI 185 Query: 176 GYMVSPLLWKKIA-------RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 G + L + +S G QS + VV R E++ FV E +W + + + Sbjct: 186 GASFTRFLTMRYRSRVKLPSPTISYGPCQSPTLGFVVSRFVEVENFVREAYWTIRVTISK 245 Query: 229 PSGE------ALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 P E L++ T + + F + LE +V + T + Sbjct: 246 PDDEKGANAPPLSIDFTWERQRLFDQL--AVLVLYEMCLENPEATVTDVRGTERTKQRPV 303 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVNMVRGYI- 339 P T L + AS +L + M +A+ LY+ G I+Y RT++ S D ++++R +I Sbjct: 304 PLCTVELHKMASRKLRMSSARCMSIAESLYQRGIISYPRTETEVFSPTMDLLSLIRVHIG 363 Query: 340 ---SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWR 396 + +K + + +AH I P + ++E + KLY+ + R Sbjct: 364 STAWGTYAQKLVDGDFLWPSDGARDDKAHPPIHPLKLMQR----SELEEEEWKLYEFVTR 419 Query: 397 QFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKG 456 F+AC A T + + A G + W V P + LP Sbjct: 420 HFLACCSEDAFGFETRVEIDIAGEGFYATGLTVLERRWLDVYPYEQWSG--NRLPRFLVN 477 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV-ENR 515 + + + ++ T+PP +EA L+ ++K GIG +T I TIQDR Y EN Sbjct: 478 ERVMPSSILMSERQTEPPPLLTEADLIDLMDKNGIGTDATMHDHIRTIQDRHYCYKNENM 537 Query: 516 RFYAEKMGEIVTDRLEENFR----ELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 +F +G + + +L D A+ME + VA + VLD S+ Sbjct: 538 QFVPTDLGVALYQGFKRLAEVSGVDLSLPDLRARMEADMALVARGAKTKQEVLDLHVSEM 597 Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC 619 + + + + GR A+ C Sbjct: 598 KRVFLLLKSHAAHMDTEMRNRL--GGLEDSVGRDGVTLVANFSECGKC 643 >UniRef50_D2MIS7 DNA topoisomerase III n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIS7_9BACT Length = 867 Score = 506 bits (1302), Expect = e-141, Method: Composition-based stats. Identities = 177/876 (20%), Positives = 301/876 (34%), Gaps = 154/876 (17%) Query: 1 MGKALVIVESPAKAKTINKYLGS-----------DYVVKSSVGHIRDLPTSGSAAKKSAD 49 MGK LVI E P+ A+ I + LG ++VV S+VGH+ +L + Sbjct: 1 MGKTLVITEKPSVARDITRALGGFQNEKNFFEGPEHVVTSAVGHMLELVAPDGVEVQRGK 60 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIY 107 P + + E + +K+L + D + Sbjct: 61 WALVNLPVIPDH-------------------FDLKPIQQNESQLKLIKKLYARKDIDSVI 101 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELN--IDRVNAQ 165 A D REGE I +L G R+ +T AIR F + + + A Sbjct: 102 NACDAGREGELIFHYLIRHFKGS-KPVRRLWLQSMTPQAIRDGFERLRDGETLLPLQRAA 160 Query: 166 QARRFMDRVVGYMVSPLLW--KKIARGLS---AGRVQSVAVRLVVEREREIKAFVPEEFW 220 R D ++G + + G S GRVQ+ + L+V+RE+EI+ F P E+W Sbjct: 161 VCRSESDWLIGINATRAMTALNSSGGGFSLTTVGRVQTPTLALLVDREKEIQHFEPREYW 220 Query: 221 EVDASTTTPSGEALALQVT-------------------HQNDKPFRPVNKEQTQAAVSLL 261 EV A SG V H KP R +K + +A V+ Sbjct: 221 EVKAIFAIASGRYEGYWVDPQLQPRSKQGVTPGAAKDQHGTAKPERIWDKTRAEAIVAQC 280 Query: 262 EKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYM 320 V E KP++ +P F ++LQ+ A+ R GF K T+ +AQ LYE + TY Sbjct: 281 ANREGRVSE-TTKPSSQQPPMLFDLTSLQREANRRFGFSAKTTLGIAQALYERHKVLTYP 339 Query: 321 RTDSTNLSQDAVNMV----RGYISDNFG----------------------KKYLPESPNQ 354 RTDS L +D V + +S G +++ N+ Sbjct: 340 RTDSRTLPEDYPKTVGTIMQSLVSSAAGPGAASSDAEGDRPISHWAERVLQEHYINGKNR 399 Query: 355 YASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLT 414 H AI P+ E+ ++ +++Y+L+ R F+A PA++++T Sbjct: 400 RIFNNAQVSDHFAIIPTG-----EAPGKLKEQERRIYELVTRCFIAAFYPPARFENTVRR 454 Query: 415 VGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVN-----KGDALTLVELTPAQH 469 + RGR+L GW +VM + + + LP + + VE+ Sbjct: 455 TVVEHQTFETRGRVLIESGWLQVMG---RKESNETLPPLASTAQDDSERAETVEIDLEGK 511 Query: 470 FTKPPARFSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVE 513 TK P R++EA+L+ +E RG+G P+T A+II + Y+ + Sbjct: 512 QTKAPPRYNEATLLSAMEGAGKLMEDDELREALQGRGLGTPATRAAIIEELIRNRYILRD 571 Query: 514 NRRFYAEKM-GEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFT 572 R ++ EL + T + E L Q+ + + + + H Sbjct: 572 ARELIPTAKATTLLRLLRALKIDELTTAELTGEWEKKLKQIESDQFSSEEFMRHIRRMTA 631 Query: 573 QQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKT 632 ++ A + + + ++ CP CG+ Y E C Sbjct: 632 DIVEAARQCDVDQIDDEY--AVLAVPCPKCGQGRVR-----------ENYRKFVCESCDF 678 Query: 633 TINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKL----HVCGNNPT 688 +I L+ E + ++ + R+ + + Sbjct: 679 SIWKSIAGRELSPNEVSSLLRDRRL---------GPLNGFRSRLGREFAAELMIKDDFTA 729 Query: 689 CDGYEIEEGEFRIKGYDGP-IVECEKCGSEMHLKMGRFGKYMACTN-----EECKNTRKI 742 + + + C KCG+ + R+ C N C Sbjct: 730 AFDFGESTKGDDVDPQTCDQVGPCPKCGAPVLDAPRRY----VCRNGLGDEPACDFKISR 785 Query: 743 LRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAG 778 + E L + + FV + Sbjct: 786 QILNRLLDAGEVRQLLDKGKTDLLQG-FVSKKNRRK 820 >UniRef50_Q55KM2 DNA topoisomerase n=3 Tax=Agaricomycotina RepID=Q55KM2_CRYNE Length = 1059 Score = 505 bits (1300), Expect = e-141, Method: Composition-based stats. Identities = 127/615 (20%), Positives = 243/615 (39%), Gaps = 44/615 (7%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGH--------IRDLPTSGSAAKKSADSTSTK 54 + L + E P+ AK+I + L + H + +L + + + + Sbjct: 2 RVLCVAEKPSIAKSITEILSGGRWDTRNGRHQYIRNYDFLYNLAPPLGNGRGANFTVTAV 61 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYE--VLPGKEKVVSELKQLAEKADHIYLATDL 112 D DP+ ++A V + V S L+ A AD + + TD Sbjct: 62 LGHLTSSDFDDDHRKWGSCDPFALFDAPVITFVDQKLKTVESNLQIEARNADILMIWTDC 121 Query: 113 DREGEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRF 170 DREGE I + + R F+ I I QA + +L++ + +A R Sbjct: 122 DREGEHIGSEVVAACKKVNRNILVKRARFSAIIPAQIHQACRQANDLDMRQADAVATRIS 181 Query: 171 MDRVVGYMVSPLLWKKIA--------RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEV 222 +D VG + L + + +S G Q + VVE+ ++AFVPE FW + Sbjct: 182 LDLKVGSAFTRLTTMTLQVRVPDLAEQLISYGPCQFPTLGFVVEQYTRVQAFVPETFWYI 241 Query: 223 DAST--TTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKP 280 + GE ++ + + F + VL+ E KP T Sbjct: 242 FVALEREHEDGEPSTVEFRWKRNHLFDLD--LAAVLYEQCTVNPQTRVLKVESKPATKWK 299 Query: 281 GAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVNMVRGY 338 P T LQQ+ S L K+ + +A++LY+ G ++Y RT++ D ++++ Sbjct: 300 PLPLTTVELQQSGSRLLHMTPKRILDLAEKLYQKGIVSYPRTETDQYDPKFDFNSLIQKQ 359 Query: 339 I----SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLI 394 + +K L + + + + +AH I P+ ++E D +++++LI Sbjct: 360 TLDNQWGAYAQKLLDGAFQKPRNGRKNDKAHPPIHPT------AHAGNLEGDERRVFELI 413 Query: 395 WRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVN 454 R+F+A T A+ +TT+ + D G ++ + +V P + LP Sbjct: 414 TRRFLASCSTNAEGQNTTVEISIADEIFSTTGLVVLRRNYLEVYPYDKWA--THALPNFE 471 Query: 455 KGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN 514 +G+ + + T P+ +EA LV ++K GIG +T A I+ I +RGYV + Sbjct: 472 EGEVFIPDVIDLKEGTTSRPSLLTEADLVGLMDKNGIGTDATIAEHIAKIIERGYVTEKQ 531 Query: 515 ----RRFYAEKMGEIVTDRLEENFRE--LMNYDFTAQMENSLDQVANHEAEWKAVLDHFF 568 + +G + + + L + E+ + + + + +L Sbjct: 532 EARIKYLVPSTLGIGLVEGFNAIGFDRSLSKPHLRRETEHRMQLICDGVRGKREILQTTI 591 Query: 569 SDFTQQLDKAEKDPE 583 ++ + KA ++ + Sbjct: 592 EEYKEVFVKARREFQ 606 >UniRef50_C9RIV4 DNA topoisomerase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIV4_FIBSS Length = 843 Score = 505 bits (1300), Expect = e-141, Method: Composition-based stats. Identities = 160/746 (21%), Positives = 288/746 (38%), Gaps = 106/746 (14%) Query: 2 GKALVIVESPAKAKTINKYLGSDY-------------VVKSSVGHIRDLPTSGSAAKKSA 48 GK L+I E P+ A + K LG+ +V ++GH+ + ++ Sbjct: 32 GKTLIIAEKPSVAADLVKVLGAKSFKKETAYYESDTTIVSHAIGHLVGIADPKDIDERYK 91 Query: 49 DSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HI 106 M P + LP + +S L +L ++ D I Sbjct: 92 AW-------------------DMKTLPMLPEKFPLVALPTTKAHLSALGKLIKRKDVTTI 132 Query: 107 YLATDLDREGEAIAWHLREVIGGDD---ARYSRVVFNEITKNAIRQAFNKPG--ELNIDR 161 A D REGE I +++ + I + + R+ +T AI+ AF E ++ Sbjct: 133 INACDAGREGELIFYYIVDYILKGNFKGKTFKRLWMQSMTPAAIKDAFEHLRTEEDMVNL 192 Query: 162 VNAQQARRFMDRVVGYMVSPLLWKKIA-----RGLSAGRVQSVAVRLVVEREREIKAFVP 216 NA R D +VG S L + + GRVQ+ + ++V+RE E F+P Sbjct: 193 RNAALCRSEADWLVGMNGSRGLTAYNSSMGGFQITPCGRVQTPTLAIIVKREEERNRFIP 252 Query: 217 EEFWEVDASTTTPS----GEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLERE 272 ++FW ++AS G+ + + D+ + ++ + Q ++ + S+ E Sbjct: 253 QKFWTIEASFDNAGAGYQGKWFTVDKENGKDRVKQIFDEARAQEILAKCKGKTGSIEE-T 311 Query: 273 DKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDA 331 P+ K G + +TLQ+ A+ R GF K T+ +AQ LYE TY RTDS L +D Sbjct: 312 TAPSQQKCGQLYDLTTLQREANNRFGFSAKTTLSIAQSLYEHYKATTYPRTDSRCLPEDY 371 Query: 332 VNMVRGYISD------NFGKKYLPE---SPNQYASKENSQEAHEAIRPSDVNVMAESLKD 382 V V+ + F ++ L + + H AI P+ V K Sbjct: 372 VAPVKATLGKIEGPLAKFAQEALDKNYVKRTPKVFDNSKISDHFAIIPTGVVP-----KG 426 Query: 383 MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALR 442 + +K+Y +I ++F+A PA+Y +TT + G+IL G+ + + Sbjct: 427 LSEAEEKIYTMICQRFIAVFFPPAQYLNTTRITTVENETFITEGKILVDPGFKAIYG--K 484 Query: 443 KGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE--------------- 487 + DE+ +P +N G+ + + + FTKPPA ++E++L+ +E Sbjct: 485 ESDEESNIPKLN-GNTAKTLAIESKEDFTKPPAHYTESTLLSMMESAGKLVEDDELRDAM 543 Query: 488 -KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE-LMNYDFTAQ 545 +RG+G P+T A+II + YV + + + L E L + + T + Sbjct: 544 KERGLGTPATRAAIIEKLVSDKYVVRDGKEMIPTAKAFDLIKVLSAMNCEALTSPELTGE 603 Query: 546 MENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSID------- 598 E +D ++ + +A ++ + + EE + Sbjct: 604 WEYKMDLISKGKESREAFMNGIIEMTKTMVKNIKGFKEESTTGEASFSPVNGKKVFETVS 663 Query: 599 CPTCGRKMGIRTASTGVFLGCS---------------GYALPPKERCKTTINLVPENEVL 643 T + IR + G L S G+ + + +N+V Sbjct: 664 RYTTEDGIVIRKITGGKHLSESEIVELLTKRKIGPLTGFRSKKGAEFSAGLIINDQNKVE 723 Query: 644 NVLEGEDAETNALRAKRRCPKCGTAM 669 V E + E + P G+ + Sbjct: 724 FVFEEKPEEIELGEVIGKSPVDGSDV 749 >UniRef50_B3JMI8 DNA topoisomerase n=15 Tax=Bacteria RepID=B3JMI8_9BACE Length = 711 Score = 505 bits (1299), Expect = e-141, Method: Composition-based stats. Identities = 138/705 (19%), Positives = 262/705 (37%), Gaps = 78/705 (11%) Query: 6 VIVESPAKAKTINK-----------YLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTK 54 ++ E P+ A+ I + Y G+ Y V ++GH+ K S Sbjct: 4 ILAEKPSVAREIARITGATRKEEGYYTGNGYHVTWALGHLVQPALPDGYGFKGFRRDSLP 63 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 + + G Y+ K + + +L ++++ I +ATD R Sbjct: 64 VIPEEFMLIPRQVKTDKG----------YKADAAAVKQIKVITKLWQESEGIIVATDCAR 113 Query: 115 EGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRFMD 172 EGE I +L G + R+ + +T AIR+ + + D A +AR D Sbjct: 114 EGELIFRYLYAYTGC-TLPFRRLWISSLTDTAIRKGLKELKDGHEYDDLYLAAKARSEAD 172 Query: 173 RVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG 231 +VG + L RG S GRVQ+ + +V +R RE + F PE ++ S + + Sbjct: 173 WLVGINGTQALTVAAGRGTYSVGRVQTPTLAMVCKRYRENRRFTPEPVHQLHFSVPSANA 232 Query: 232 EALALQVTHQNDKPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFITSTLQ 290 + + + +K + + ++ +V + E K P + +TLQ Sbjct: 233 GTVV-----KFASVKKWQDKNEAAILYNKVKAKMCATVTKVEKKEKVENPPLLYDLTTLQ 287 Query: 291 QAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 + A+T+ GF ++T+ + Q+LYEA +TY RT S ++ +D + G L + Sbjct: 288 KEANTKHGFTAEQTLELVQKLYEAKLVTYPRTSSRHIPEDVFAEIPLLFERLAGHSTLSD 347 Query: 351 SP------NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMT 404 N+ + + H A+ + + + Q +Y +I + V Sbjct: 348 KIVNLDGLNRRSVDASKVTDHHALLVT-----PNRPLALYKNEQIIYDMIAGRMVEAFSE 402 Query: 405 PAKYDSTTLTVG--------AGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKG 456 D+ T+ +A+G I+R GW V + + + LP +G Sbjct: 403 ECVKDTATVVAEVVPDAGERCEGLTFEAKGCIVRKAGWRGVYGEYGEDNGNTALPDWTEG 462 Query: 457 DALTLVELTPAQHFTKPPARFSEASLVKELEKR-----------------GIGRPSTYAS 499 D L + + + T+P +E+SL+ +E GIG P+T A+ Sbjct: 463 DTLVMAGCSMSSGMTRPKPLHTESSLLAAMETAGRDDVEDEEARQALKDCGIGTPATRAA 522 Query: 500 IISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAE 559 II T+ R Y+ + + G + +++ ++ N + T + E L ++ + Sbjct: 523 IIETLIRREYMVRVKKSLVPTEKGLALYSIVKDM--DIANVEMTGRWEAELAEIEKGKTP 580 Query: 560 WKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGC 619 +A + S + G + + CP CG+ G + C Sbjct: 581 HEAFMRDIESYTRKITTDLLACDRIFGHK-----ASGCTCPKCGKGTMQF---YGKVVRC 632 Query: 620 SGYALP-PKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCP 663 P R L + +G+ ++++ P Sbjct: 633 DNPDCALPVFRQIAGKTLTDGEMTDLLAKGKTEVLGGFKSRQGKP 677 >UniRef50_C1DYX0 Predicted protein n=4 Tax=Viridiplantae RepID=C1DYX0_9CHLO Length = 861 Score = 505 bits (1299), Expect = e-141, Method: Composition-based stats. Identities = 165/796 (20%), Positives = 276/796 (34%), Gaps = 76/796 (9%) Query: 4 ALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDE 63 L + E P+ A +I +L G + + D Sbjct: 7 VLCVAEKPSLAASIAGFLSEGKHRSRRGGQEVHEFERDFNGARCHFKVTAVIGHVLSIDF 66 Query: 64 RGALVNRMGVDPWHNWEAHYEVLPG--KEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 + +DP ++A + K +VV L++ A+ A H+ L D DREGE I + Sbjct: 67 PAKFQSW-DLDPAILFDAPVQKKEATPKARVVEHLEREAKGASHLILWLDCDREGENICF 125 Query: 122 HLREVIGGDDAR------YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVV 175 + + R F+ ++K +I +A G N A AR+ +D V Sbjct: 126 EVIDACAPVMRPNRGDTFVHRAKFSAVSKESIERAMRTLGAPNRAEALAVDARQELDLKV 185 Query: 176 GYMVSPLLWKKIAR--------GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 G + + +S G Q+ + V+R EI + PE+FW + Sbjct: 186 GVAFTRFQTRFFQGRYSHLDASVISYGPCQTPTLNFAVQRHLEIVSHTPEDFWSLHVEVR 245 Query: 228 TPS-GEALALQVTHQNDKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTSKPGAPFI 285 + S G+ L + + R + + + S++ V E+ + Sbjct: 246 STSLGKTLVTRW-----ERERVFDGDVGEMFRSMVAGDRHALVESVEETEEFKRRPPGLN 300 Query: 286 TSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGK 345 T L +AAS +G G + M +A+RLY G+I+Y RT+ST ++G + G Sbjct: 301 TVDLLKAASAGMGMGAHRAMQVAERLYIQGFISYPRTESTAYPPGF--DLKGTLKAQRGH 358 Query: 346 -------KYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 + L + H I P + +A +LY + R F Sbjct: 359 PDWGEWVEELLAGSMTKPRGGKDEGDHPPITPVRSATESAVGG---GEAWRLYDFVARHF 415 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 +A Y S T+ AG R + G+ + GWT VMP D+ L + +G++ Sbjct: 416 IASVSPDCAYVSRRATLVAGGERFRVSGQTVIAPGWTTVMPHRAVEDD--PLGEIERGES 473 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE---NR 515 L + + Q T PP SEA L+ +E+ GIG ++ + I+ I+ R YV ++ R Sbjct: 474 LPIATVELRQGATSPPPYLSEAELIGLMERNGIGTDASIPTHINNIESRKYVTIQSQGGR 533 Query: 516 RFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAV----LDHFFSDF 571 R +G + EL + +E LD +A +A+ +++ L F + F Sbjct: 534 RVVPTDLGVTLVQGYHRIDPELALPAVRSHVEKQLDMIATGKADHESIVRHTLAQFAAKF 593 Query: 572 TQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCK 631 +D+ E+ + + CGR C Y Sbjct: 594 RNFVDQIERMDTLFEASFDPTCSSGKPFSKCGR--------------CLRYMRLVS---- 635 Query: 632 TTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDG 691 T + A T L R C CG + Y R +C P C Sbjct: 636 -TRPQRLYCPTQEEVLELPAGTVKLYNNRECQLCGFELLLYQNG-DRTYPMC---PWCFN 690 Query: 692 YEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKIL-RNGEVAP 750 + G R + + + C EC K+ R G Sbjct: 691 HPPFVGGSRPTKGLVSGAPHPRAHPIVDAL-------VVCPCPECGEDDKLKGREGGWLM 743 Query: 751 PKEDPVPLPELPCEKS 766 + P + C Sbjct: 744 LEPVGGPRWKFVCTGC 759 >UniRef50_C0QUY8 DNA topoisomerase n=1 Tax=Persephonella marina EX-H1 RepID=C0QUY8_PERMH Length = 834 Score = 505 bits (1299), Expect = e-141, Method: Composition-based stats. Identities = 163/816 (19%), Positives = 316/816 (38%), Gaps = 89/816 (10%) Query: 4 ALVIVESPAKAKTINKYLG------------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 L+I E P+ A K + +Y + +VGH+ + Sbjct: 2 KLIIAEKPSVAIDTAKAISPKFQKKDGYIEAGEYTITWAVGHLLE--------------- 46 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATD 111 D ++ P + Y+V GK K + +K L +KAD I++ TD Sbjct: 47 --------IDDTIAPKEWKLETLPILPEKFEYKVSKGKNKQFNIVKSLVKKADEIFVNTD 98 Query: 112 LDREGEAIAWHLREVIGGDD-ARYSRVVFNE-ITKNAIRQAFN--KPGELNIDRVNAQQA 167 REGE IA + G + + R +E +TKN I + KP + + A Sbjct: 99 AGREGELIARLILLYSGWNGWDKTYRFWTSEALTKNVILRELKARKPAKNWDSLFYSGLA 158 Query: 168 RRFMDRVVGYMVSPLLWKKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 R+ D +VG ++ L + G S GRVQ+ ++L+VER+ EIK F P+ +W+++A Sbjct: 159 RQQSDWLVGINLTRALTVIVGDGSVWSIGRVQTPVLKLIVERDLEIKNFKPKPYWQLEAV 218 Query: 226 TTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKA-RYSVLEREDKPTTSKPGAPF 284 S + A + N+K +K + L+ + V E E K F Sbjct: 219 FEKDSQKFKAKLL---NEKDTIFEDKNKIWEIFKALKDKDKAVVKEIEKKQHKKYAPPLF 275 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQD--AVNMVRGYISDN 342 +TLQ A+ R GF +KT+M+AQ LYEA YI+Y RT++ +L ++ ++V+ + Sbjct: 276 SITTLQMTANKRFGFTAQKTLMLAQDLYEAKYISYPRTEAQHLDENPSTKDLVKNILKKL 335 Query: 343 FGKKYLPE--SPNQYASKENSQEAHEAIRPSDVNVM-AESLKDMEADAQKLYQLIWRQFV 399 ++ + + + H AI P ++ + + D K+Y+LI +F+ Sbjct: 336 GEEQLIENVDKVGKRVFDSSKLTDHYAIIPMNLLTEEKAKKEGLNQDHLKIYELIKNRFL 395 Query: 400 ACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDAL 459 A M P +Y++T + ++ A G++ GW + + LP + KGD + Sbjct: 396 AVFMPPYEYETTKAILDIDGYQFTASGKVELSLGWKAIDREDEDDKIEAPLPQLEKGDMV 455 Query: 460 TLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYA 519 + + TKPPA ++E++L+ ++++ +G +T A II T++DR Y++ + + A Sbjct: 456 HKISQRVIEDKTKPPAHYTESTLLNKMKQLELGTGATRAGIIQTLKDRFYIKNKGKSLIA 515 Query: 520 EKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVAN---HEAEWKAVLDHFFSDFTQQLD 576 + G + +++++ +E + T++ E L+Q+ + ++ L+ ++++ Sbjct: 516 TEKGFALIEKIKD--KEFASPKMTSKWEQQLEQIYTQKLGKKGYEDFLNQIKEFTKKEVE 573 Query: 577 KAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 + + +P CG + G + C C + Sbjct: 574 AVKGISIQMEQKPVG-------RCRCGGDVFE----YGKYYQC--------GSCNLKVWK 614 Query: 637 VPENEVLNVLEGEDA-ETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIE 695 ++ L E + + + K G + L + + + Sbjct: 615 EVFSKKLKEKEALLLYQGTTVYVEGLKGKSGKKFGAGLKLTDEGKIELVFDESQIDTLAK 674 Query: 696 EGEFRIKGYDGPIVECEKCGSEMHL-KMGR-----------FGKYMACTNEECKNTRKIL 743 + C+ C + + G+ G+ + + K + Sbjct: 675 CKCGGVIVEADKSYYCKSCKAVVWKEISGKKISKNIALKLFKGEKVKVKGFKSKAGKNFE 734 Query: 744 RNGE--VAPPKEDPVPLPELPCEKSDAYFVLRDGAA 777 PK + + Sbjct: 735 AILCLENGKPKMEFPENEPIGKCSCGGEIFEYSNRY 770 >UniRef50_Q01NZ0 DNA topoisomerase n=2 Tax=Acidobacteria RepID=Q01NZ0_SOLUE Length = 1333 Score = 504 bits (1298), Expect = e-141, Method: Composition-based stats. Identities = 137/648 (21%), Positives = 247/648 (38%), Gaps = 95/648 (14%) Query: 2 GKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADS 50 G V+ E P+ A+ I + LG + YVV ++GH+ L G + Sbjct: 7 GNVAVLAEKPSVARDIARVLGAGTKGEGFLHGNGYVVTWAIGHLAALAQPGEIDPQWR-- 64 Query: 51 TSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAE--KADHIYL 108 R P + V + +K++ K + Sbjct: 65 -----------------PWRRNTLPMLPRQWPLVVYEKTKDQFETVKRILNSPKIARVVC 107 Query: 109 ATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQ 166 ATD REGE I ++ E G + SR+ + +T +AIR+ F+ +A + Sbjct: 108 ATDAGREGELIFRYIYEAAGCE-KPVSRLWISSLTPDAIRKGFDALRPAADYDGLADAAR 166 Query: 167 ARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 R D +VG +S + LS GRVQ+ + ++VERE ++ FVPE++ EV A+ Sbjct: 167 GRSRADWLVGMNLSRAYSLAYSEDLSVGRVQTPTLAMLVERELTVRNFVPEDYMEVLATF 226 Query: 227 T-TPSGEALALQVTHQNDKPF------------RPVNKEQTQAAVSLLEKARYSVLERED 273 T + + Q T D+ P + E+ + + ++ + Sbjct: 227 HPTGAPKESVYQGTWFRDRVPGADKESQQQAMRLPPDGEEANRIAARARTGQAAIESIDA 286 Query: 274 KPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAV 332 + P + + LQ+ A+ GF +KT+ AQ LYE I+Y RTDS +LSQD Sbjct: 287 QTQRMAPPPLYDLTELQRHANRLFGFSAQKTLDTAQALYERHKLISYPRTDSRHLSQDVA 346 Query: 333 NMVR---GYISDNFGKKYLPESPNQY----ASKENSQEAHEAIRPSDVNVMAESLKDMEA 385 + I++ + + P + + + H AI P+ V + + + Sbjct: 347 RTLPRVVAAIAEPYRELLAPGTGERPLGRRFVDDAKVTDHHAIIPT---VTSAANAQLAP 403 Query: 386 DAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGD----FRLKARGRILRFDGWTKVM--- 438 D +K+Y LI R+ ++ ++ TT+ + R + G ++ GW + Sbjct: 404 DERKIYDLICRRLLSAWHEDHIWNVTTVITAIRNAAVIDRYHSSGSAVQQLGWKVLDLAP 463 Query: 439 ----------PALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE- 487 A E + P + G ++ + T+ P RF+E +L+ +E Sbjct: 464 AKAKRAKSPGTADADRGEQELPPGLASGQPQDVLNAEALKKKTRAPKRFTEGTLLTAMET 523 Query: 488 ---------------KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEE 532 + G+G P+T A+II + R Y+ + A G + + + Sbjct: 524 AGKTLDEKELSDAMKETGLGTPATRANIIEVLLKREYIVRNGKSLEATDKGVHLIEVVH- 582 Query: 533 NFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEK 580 E+ + T Q E L ++ A+ + + K + Sbjct: 583 --PEVRSPIMTGQWEAYLHRIHRGNAQLDPFMHGIEEYVRDVVGKVGQ 628 >UniRef50_B8G1K2 DNA topoisomerase n=2 Tax=Desulfitobacterium hafniense RepID=B8G1K2_DESHD Length = 777 Score = 504 bits (1298), Expect = e-141, Method: Composition-based stats. Identities = 159/819 (19%), Positives = 289/819 (35%), Gaps = 111/819 (13%) Query: 1 MGKALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSAD 49 MGK L+I E P++A+ K LG +Y++ +GH+ +L + Sbjct: 1 MGKTLIIAEKPSQAREYAKTLGVKGKREGYFENDEYIISWCIGHLFELKAPENY------ 54 Query: 50 STSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAE--KADHIY 107 K + + R+ V P E Y + G K L+ L + + Sbjct: 55 -------MDLPKVGKRWSIRRLPVLP-RLGEFQYGLKSGTAKQFKVLQGLLRSPEVQQVI 106 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNI--DRVNAQ 165 TD DREG+ + + + +G R+ + +T+ AIR+ +K + A Sbjct: 107 CGTDADREGQLLFQEVWDAVG-SKKPLFRLWISSLTQEAIREGMSKLRPVGEVEGLAQAG 165 Query: 166 QARRFMDRVVGYMVSPLLWKKIA---------RGLSAGRVQSVAVRLVVEREREIKAFVP 216 R + D G ++ +S GRVQ+ + LVVE+E I+ FVP Sbjct: 166 YGRSYGDWDFGMNLTEGFTALFGSFDPVRKKPNVISIGRVQTPTLALVVEQEWAIENFVP 225 Query: 217 EEFWEVDASTTTPSGEALALQVTH----------QNDKPFRPVNKEQTQAAVSLLEKARY 266 + EV+A + G + D ++ ++ + V+ ++ Sbjct: 226 VAYVEVEAEFASGQGSYKGKWFDPAVKNTRDKNQETDNAQMMLDLDRGKEIVAKVQGKPG 285 Query: 267 SVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTN 326 + +DK T F ++L +AS R GFG +K + +AQ LYE ITY RTD Sbjct: 286 RIRSVKDKETKEPHPLLFDLTSLTVSASKRYGFGAEKVLKIAQSLYEKKAITYPRTDCNY 345 Query: 327 LSQDAVNMVRGYISDN-------FGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAES 379 L D + ++ ++ + K+ L N AH AI P+ ++ Sbjct: 346 LPPDMLPKLKVHLQALEQSPFASWVKEALDNPLPGGKRVINEITAHHAIIPTTEKMIP-- 403 Query: 380 LKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP 439 ++ D +K++++I +F+ PA+Y + + +G+ L GW K+ Sbjct: 404 --NLSPDERKIWEMIVLRFLCIWFPPARYAEKEVVTVVEEEFFLTKGKTLLESGWKKIEN 461 Query: 440 ALRK-GDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------- 487 + LP + + + + Q TKPP R+++ L+K +E Sbjct: 462 TEKYTEGSGLQLPLLQQNEEVVTRSCQALQKETKPPKRYTQGDLIKAMEGAGKEIEDETL 521 Query: 488 -----KRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRE---LMN 539 +G+G +T +II + DRGY+ + + G + ++E L++ Sbjct: 522 RRQLKGKGLGTVATRGAIIENLLDRGYLLQQQKVLVPTAKGTELIRLIKERLPRAQLLIS 581 Query: 540 YDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDC 599 + T QME L QV E ++ +++ G +P Sbjct: 582 AEMTGQMEYELAQVERGELPLSRYMEKVEEAIRGIIEELRHYEATRGKKPLAFAP----- 636 Query: 600 PTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAK 659 + ++G + E + + + E + A Sbjct: 637 --------QKAGASGR------KSKSNLEEKPQELPVQAKVTKAAKTRQESPASAAEENL 682 Query: 660 RRCPKCGTAMDSYLIDPKRKLHVCGNNPT-CDGYEIEEGEFRIKGYDGPIVECEKCGSEM 718 CP CG + + C N C + + K G Sbjct: 683 GICPSCGGGVVEREKG-----YGCQNWKNGCPFILWKNPICGKVLTPAQVKSLLKKGKTN 737 Query: 719 HLKMGRFGK------YMACTNEECKNTRKILRNGEVAPP 751 +K R Y+ + + N + A P Sbjct: 738 LIKGFRSKNGSVFAAYLVWEDPSSGKLKFEFENNDRAKP 776 >UniRef50_D0JAY2 DNA topoisomerase n=2 Tax=Blattabacterium RepID=D0JAY2_BLASB Length = 704 Score = 504 bits (1297), Expect = e-141, Method: Composition-based stats. Identities = 229/714 (32%), Positives = 351/714 (49%), Gaps = 81/714 (11%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M + LVIVESP KA TI +LG DY V SS GHI DLP Sbjct: 1 MKENLVIVESPTKAYTIQTFLGKDYYVVSSYGHIIDLPEKE------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GV+ N++ +Y +L K+K+V LK L + I+LA+D DREGEAIA Sbjct: 42 ----------IGVEIKDNFKPNYVILSKKKKIVQNLKILIKNHKIIWLASDEDREGEAIA 91 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 + + + D +Y R+VF+EITK AI A P +N D V AQQARR +DR+VG+ +S Sbjct: 92 YQIYKTFNIPDRKYRRIVFHEITKKAIFNAIKNPRSINYDLVYAQQARRILDRLVGFQLS 151 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LWKK+ RGLSAGRVQS AV+L+VE+E +I+ F+P ++V + ++ Sbjct: 152 PVLWKKVKRGLSAGRVQSAAVKLIVEQENKIQKFIPSPTYQVYGVFSNEQKMIFNAKLDK 211 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 + + + N +SL + + V + K P PF TS+LQQ A +L + Sbjct: 212 KIEDKKKMKN------ILSLCINSSFLVKKIVIKHEKKNPPPPFTTSSLQQEACKKLNYS 265 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 + KTM +AQ+LYE G+ITYMRTDST+LS+D ++ ++ YI +GKKYL K + Sbjct: 266 ISKTMFLAQKLYEKGFITYMRTDSTSLSKDILSEIKDYILSLYGKKYLSTKEFSKGQKFS 325 Query: 361 SQEAHEAIRPSDVNVMAES-LKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG- 418 QEAHE+I P+ +N + + L ++ ++LYQLIW + + QM + + + + Sbjct: 326 -QEAHESIHPTVINHIDNNYLNFLDIYQKRLYQLIWERTIMGQMIDSVIEKKDFYIQSSH 384 Query: 419 -DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARF 477 D R + DG+ K++ E + + +G L E+ Q R+ Sbjct: 385 FDDFFIWTKRTVLLDGFMKIVNQDENKKEKLSVLEMKQGTHLQRKEIIAKQIIPSRIHRY 444 Query: 478 SEASLVKELEKRGIGRPSTYASIISTIQDRGYV--------------------------- 510 +EASLV LEK GIGRPSTY IIS IQ R YV Sbjct: 445 NEASLVNNLEKLGIGRPSTYVPIISAIQKRNYVSIQKIIKKTETRKNFLLKGNSIIEKNE 504 Query: 511 ---RVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHF 567 +E +F ++G ++T+ L++NF E+++Y+FTA +E + D +A + W +L +F Sbjct: 505 QITEIEKNKFIPTEIGVLITNFLKKNFAEIVDYNFTANLEKNFDDIAKGKQSWIKILQNF 564 Query: 568 FSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPK 627 + +F +++ E+ ++ P +K+ + A G + + K Sbjct: 565 YDEFHKKIQYVEEYVDKIHKERFL-----GIDPKSNKKIFSKIARFGPIVQMGEFKDKEK 619 Query: 628 ERC-----KTTINLVPENEVLNVLEGEDAET--NALRAKRRCPKCGTAMDSYLI 674 + TIN + E L +LE + + K + Sbjct: 620 PKFSPLLNSQTINTISFTEALKILELPKSLGFFEEEEVLLKINKYNIYIKHKKK 673 >UniRef50_C5PM09 Possible DNA topoisomerase n=1 Tax=Sphingobacterium spiritivorum ATCC 33861 RepID=C5PM09_9SPHI Length = 704 Score = 504 bits (1297), Expect = e-141, Method: Composition-based stats. Identities = 146/733 (19%), Positives = 278/733 (37%), Gaps = 85/733 (11%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 +VI E P+ A+ + + +G + Y + GH+ L T + + Sbjct: 2 KVVIAEKPSVARDLARVMGAKEVNDGYISGNGYAFTYAFGHLVQLCTPQAYG--FHTWSV 59 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + P + + + + + G K ++ +K L +KA+ + +ATD Sbjct: 60 SNLPIIPAQFKLESKKVKKDGKQMDDG--------GALKQLNTIKGLLDKAEEVIVATDA 111 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 REGE I ++ +G + + R+ + T AI++ F E + ++R Sbjct: 112 GREGELIFRNIYYYLG-ANVPFKRLWISSQTDKAIKEGFANLKEGSEYDSLYMSARSRSE 170 Query: 171 MDRVVGYMVSPLLWKKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D ++G + + LS GRVQ+ + ++ R E K F P F+++ A Sbjct: 171 SDWLIGINATQAITLAAGNRGLLSLGRVQTPTLAMICSRFIENKNFKPTAFYKIQAQFEK 230 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLE-KARYSVLEREDKPTTSKPGAPFITS 287 + + A R K+ + ++ + A V + E K P + + Sbjct: 231 ENIKFKATS--------NRIDQKDLAEETLAKITVGASAKVTKVEGKEVKEPPPLLYDLT 282 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFG--- 344 LQQ A+ + G+ +T+ +AQ LYE ITY RT S + +D + Sbjct: 283 NLQQDANKKYGYSADQTLSIAQTLYEKKVITYPRTGSRYIGEDVFEKIEELFQHLADTAE 342 Query: 345 -------KKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 + + N+ + + H A+ +D E M + +Y +I ++ Sbjct: 343 EGIATISRNLIGAKLNKRSVDDKKVTDHHALLVTD-----EKPSAMLKEQSNIYNMIAKR 397 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGD-----------E 446 V D TT+ + A L A+G +++ GW L + + E Sbjct: 398 MVESFSDVCLKDITTVIMDAEGVELIAKGTVIKQYGWRLSADQLEQPEDDKKDNDDADTE 457 Query: 447 DRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELE----------------KRG 490 + LP ++ + L ++ L + FTK +EASL+K +E G Sbjct: 458 NAQLPKLSAEELLEILALDLMEKFTKAKPVHTEASLLKAMETSGKEIDDDEMRQAMKDCG 517 Query: 491 IGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSL 550 +G P+T A+ I T+ R Y+R + ++ G V + +++ + + T + E L Sbjct: 518 LGTPATRAATIETLFQRDYIRRDKKKLIPTDKGLAVYNLVKDRA--IAKVELTGKWEQKL 575 Query: 551 DQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLT-SIDCPTCGRKMGIR 609 +++ ++ + + H + + + T SI CP C + I Sbjct: 576 EEMRANKVSYDVFMKHIKDFTVRITKELLQLRISLTQDVEPPKQTVSIKCPKCDKGSMIL 635 Query: 610 TASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAM 669 C YA + T++ V E E +T AL+ + K G + Sbjct: 636 YEKVA---QCDHYARGCDFKIWRTLSGVTLEEKEMKNLLEKGKTGALKNLQ--DKEGKKV 690 Query: 670 DSYLIDPKRKLHV 682 D L+ K+ + Sbjct: 691 DGVLVFENLKVSI 703 >UniRef50_Q5NWJ2 DNA topoisomerase n=31 Tax=root RepID=Q5NWJ2_AZOSE Length = 694 Score = 503 bits (1296), Expect = e-140, Method: Composition-based stats. Identities = 154/715 (21%), Positives = 266/715 (37%), Gaps = 82/715 (11%) Query: 5 LVIVESPAKAKTINKYLG-----SDYV------VKSSVGHIRDLPTSGSAAKKSADSTST 53 L I E P+ AK I LG ++ V GH+ + Sbjct: 3 LFIAEKPSVAKAIASELGQSGKGDGFIECGTDTVTWCFGHMLEQAEPDEY---------- 52 Query: 54 KTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLD 113 T ++ RG + R+ P + + ++ ++ + +L ++A I A D D Sbjct: 53 -TPDDVPRNARGKKIWRVDELPIIPTDWMLKAKDDAKQQLAVIGKLLKEAAEIVNAADPD 111 Query: 114 REGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQARRFM 171 REG+ + + E + R + ++++ + +A +AR+ Sbjct: 112 REGQLLVDEVLEHFRC-NKPARRFWVSAQDSVSVKRGLAALKDNGTYHGWADAARARQRA 170 Query: 172 DRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAST 226 D ++G +S + RG L+ GRVQ+ + LVV R+REI+AF P + + A+ Sbjct: 171 DWLIGMNLSRAYTLRAQRGGSRGLLTVGRVQTPTLTLVVARDREIEAFKPIPYHTIRAAI 230 Query: 227 TTPSGEALALQVTHQN----DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 G LA + D R V+ A V+ + +V E + Sbjct: 231 QHSGGAFLASWRAKVDQAGLDAEGRLVDTAVADALVAKVTGKPGTVAEYTQEAKKQNQPL 290 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT-YMRTDSTNLSQDAVNM------V 335 F S + AS + G+ + + Q LYE +T Y RTD L + Sbjct: 291 AFALSDITLLASNKFGYSAEDVLNACQTLYETHKLTSYPRTDCAYLPESQHADSPRVLKA 350 Query: 336 RGYISDNFGKKYLPESPN--QYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 +++ P ++ AH I P+ + S + + +Y L Sbjct: 351 IQHVNPELAGLVAGADPRLKSKTWNDSKITAHHGIIPT---MHNGSKAGLIERERNIYDL 407 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPA--------LRKGD 445 I R ++A +Y STT+ V D A G+++ +GW V Sbjct: 408 IVRAYLAQFYCVHEYMSTTVVVEVEDETFVATGKVVTRNGWRDVYQEVDEQDTEKDADEG 467 Query: 446 EDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR---------------- 489 ++ LPA+ KGD +T + T TKPPARF+E +L++ +E Sbjct: 468 GNQRLPAMQKGDGVTCKQATRKDAKTKPPARFTEGTLLRAMENIHKVVPEPEHKKMLREE 527 Query: 490 -GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMEN 548 GIG +T ASIIS ++ RG++ + ++ +G + D L E + + TA E Sbjct: 528 DGIGTSATRASIISELKRRGFLETKGKQIIGTTLGRSMIDALPEVVK---SPVLTALYER 584 Query: 549 SLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD-PEEGGMRPNQMVLTSIDCPTCGRKMG 607 L + AE A + + Q+ KA G R + T C CG+ + Sbjct: 585 MLKGIEQGTAELAAFIAKQETFIRDQVTKANDGAVAIAGGREALPISTLYKCMACGQGLI 644 Query: 608 IRTASTG--VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKR 660 R + CS + CK + ++ + N ++ Sbjct: 645 RRPTKKADVFWWACSNFPT-----CKQSYPESKNPKLKGRPDYSTGRNNTHEQEQ 694 >UniRef50_A8XHL1 DNA topoisomerase n=2 Tax=Caenorhabditis briggsae RepID=A8XHL1_CAEBR Length = 774 Score = 503 bits (1295), Expect = e-140, Method: Composition-based stats. Identities = 156/791 (19%), Positives = 288/791 (36%), Gaps = 68/791 (8%) Query: 1 MGKALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDL-------------PTSGSA 43 M +AL + E AK + L + KS I L P Sbjct: 1 MKRALFVAEKNDVAKGVAAILSNGTSNRKEGKSKFNKIYTLNSELFGQVNTVLIPFFQRL 60 Query: 44 AKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHY--EVLPGKEKVVSELKQLAE 101 +++A S ++ + + N +EA V P + + L++ A+ Sbjct: 61 FQRAAISVTSVSGHLMNWQFHENMSNWQTTSMVELFEAPVRHVVTPDMKLIEKTLREEAQ 120 Query: 102 KADHIYLATDLDREGEAIAWHLREVIGGDDARY--SRVVFNEITKNAIRQAFNKPGELNI 159 + D + + TD DREGEAI + +V + R R F+EITK AI +A L+ Sbjct: 121 RHDVLVVWTDCDREGEAIGAEIVKVCRESNRRIDIYRARFSEITKAAITRAARNLIRLDE 180 Query: 160 DRVNAQQARRFMDRVVGYMVSPLLWKKIA-------------RGLSAGRVQSVAVRLVVE 206 V A R +D +G + L + + +S G Q + V + Sbjct: 181 KIVAAVDCRSELDLRIGSAFTRLQTLHLRNRFSSLLGQSDSSKVISYGSCQFPTLGFVTD 240 Query: 207 REREIKAFVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEK-AR 265 R + I+ F+ E FW++ T + L R +++ ++ Sbjct: 241 RYKLIENFISEPFWKLAVEHTREGHKVEFLW------DRNRLFDRDVVDILHDECKEAKE 294 Query: 266 YSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDST 325 V + KP + T L++ ++L K+TM +A++LY G+I+Y RT++ Sbjct: 295 AHVEKVTKKPKSKWRPQALDTVELEKLGISKLRMSAKQTMQVAEKLYSKGFISYPRTETN 354 Query: 326 NLSQDA------VNMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAES 379 V+ +F + L + + S EAH I P + Sbjct: 355 KFPPGLNLTPLVEQQVQSTTWGDFATEVLQKGV-TPRNGHKSDEAHPPIHP----LTFAD 409 Query: 380 LKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMP 439 + D K+Y+L+ R F+AC A+ + T + + G + + G +R G+ KV Sbjct: 410 KNTLHGDDWKVYELVVRHFLACVSQDAQGEETMVNLRVGSEKFHSSGLRIRDMGYLKVYV 469 Query: 440 ALRKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYAS 499 + G +R+LP N+G+ + +L T+PP +EA L+ ++K GIG +T+A Sbjct: 470 YEKWG--NRLLPTYNQGERFSDYKLKIGDGKTQPPDLLTEADLIALMDKFGIGTDATHAE 527 Query: 500 IISTIQDRGYVRVE-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 I I+ R Y+ V+ + + +G + D ++ + D A +E L + + Sbjct: 528 HIEKIKTREYIGVKPDGKLIPSFLGLALVDGYDDMGFAMSKPDLRANLEMGLKDICDGRR 587 Query: 559 EWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG 618 + + VLD + ++E++ E + + + G G G G Sbjct: 588 QKQEVLDEQIGKYKSIFVESERNIEVLSQSLQRYLNKNQQAGGGGGGGGGPPRGPGGGGG 647 Query: 619 CSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCG---TAMDSYLID 675 G + + + + +DA + G Sbjct: 648 GGGSRGSGPPKPPPKPRGRQSKKSKSPAKNDDAGEDNDTIVTLSEVLGSLTNPKPRKPRA 707 Query: 676 PKRKLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNE- 734 P++ + P E EE +V+ + + K+ C+ Sbjct: 708 PRKSAPAQADGPNGLENEEEEVMCTCPEPMKAVVKVVQKEGP-----NKGKKFYTCSLPY 762 Query: 735 ----ECKNTRK 741 +C + Sbjct: 763 TSSDKCNFFKW 773 >UniRef50_Q04TE1 DNA topoisomerase n=4 Tax=Leptospira RepID=Q04TE1_LEPBJ Length = 613 Score = 503 bits (1294), Expect = e-140, Method: Composition-based stats. Identities = 205/645 (31%), Positives = 334/645 (51%), Gaps = 60/645 (9%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M +L+IVESP+KAKTI YLG ++ + +++GH+ DLP Sbjct: 1 MS-SLIIVESPSKAKTIGGYLGKEFRILATLGHVADLP---------------------- 37 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +G+D + +E Y VLPGK+K++SE+ + A+++ I+LATD DREGE I+ Sbjct: 38 -------KTTLGLDLKNRFEPEYVVLPGKKKILSEIIKAAKESQRIFLATDPDREGEFIS 90 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 ++R+ + + R+ F EIT+NAI + P ++ V AQ+ RR DR++GY +S Sbjct: 91 AYIRDRLK-KKSNVFRIRFTEITRNAILSSLQNPDTIHESLVEAQKTRRVGDRLIGYFIS 149 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P+LW++I GLSAGRVQSVA++ + +RE EI+ F E ++ V G Q Sbjct: 150 PVLWREIGPGLSAGRVQSVALKWICDREDEIRNFHSEIYYNVLLYVHDKKGIEGVFQRVG 209 Query: 241 QNDKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGF 299 R ++E+ + ++K + E+++ + P PF T++LQQ A +L F Sbjct: 210 D-----RIFSEEKANLILQNVQKEKNLRISEKKESHKKNLPPPPFQTASLQQEAFRKLRF 264 Query: 300 GVKKTMMMAQRLYEA---------GYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPE 350 KKTM +AQ+LYE G ITYMRTDS LS D V +I FG+ + + Sbjct: 265 SSKKTMSIAQKLYEGMDLGNGKREGLITYMRTDSVRLSPDFVERANSWIISEFGETFANK 324 Query: 351 SPNQYASKENS-QEAHEAIRPSDVNVMAESLKD-MEADAQKLYQLIWRQFVACQMTPAKY 408 + Q+AHEAIR +D + +ES K+ + + LY+LIW++ ++ + P ++ Sbjct: 325 LERKVKKSSKKIQDAHEAIRITDPFLTSESAKNFLGKEEASLYELIWKRTISYLLPPEEF 384 Query: 409 DSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQ 468 +T ++ + + F G+ + A +K + P KG+ LTL + + Sbjct: 385 LNTEYSIFVAGEYFQLETKKTLFPGYKILNEADKKAN-----PNWEKGELLTLQKAECEK 439 Query: 469 HFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528 T+P R+SE +LV +LE+ GIGRPSTY+++ + R YV E + FY +GE V Sbjct: 440 KQTEPSPRYSEGTLVAKLEREGIGRPSTYSTVSEILVKRKYVEQEKKFFYPLPLGEKVNF 499 Query: 529 RLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAE-----KDPE 583 L+ F +L FTA++E++LD++ +E + +L+ +SD Q+ ++ E Sbjct: 500 FLQSGFGDLFREKFTAELESNLDRIEKNEIDSLVILNRLWSDLQTQIQNSKFVASVFRKE 559 Query: 584 EGGMRPNQMVLTSIDCPTC--GRKMGIRTASTGVFLGCSGYALPP 626 +R + + CP C G +T+ F CS + Sbjct: 560 WAEIREKKKETSWGICPLCRDGSLQKKKTSRKKEFYQCSRFPDCE 604 >UniRef50_Q1QVL1 DNA topoisomerase n=1 Tax=Chromohalobacter salexigens DSM 3043 RepID=Q1QVL1_CHRSD Length = 654 Score = 503 bits (1294), Expect = e-140, Method: Composition-based stats. Identities = 139/656 (21%), Positives = 236/656 (35%), Gaps = 77/656 (11%) Query: 5 LVIVESPAKAKTINKYLG------SDYVV------KSSVGHIRDLPTSGSAAKKSADSTS 52 L+I E P+ A+ I L Y+V VGH+ + + + Sbjct: 3 LIIAEKPSLARAIADALPTAPQRHEGYLVCGETCISWCVGHLLEQAPPDAYDARYQQWRL 62 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 P+ + ++ +++L ++AD + A D Sbjct: 63 DHLPIVPR-------------------QWKLIPRSKARAQLAVIRKLLKRADTVVHAGDP 103 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQQARRF 170 DREG+ + + +G SR++ +++ + A+RQA + A +AR Sbjct: 104 DREGQLLVQQVIAHLGWR-GSISRLLVSDLNRPAVRQALQCIEDNARYQSLFEAAEARSR 162 Query: 171 MDRVVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDAS 225 D V G +S LS GRVQ+ + L+V R+ +I+AF P F+ + A Sbjct: 163 ADWVYGINLSRAWTLTGRQAGYQGVLSVGRVQTPVLGLIVRRDLDIEAFTPRPFYPLWAD 222 Query: 226 TTTPSGEALALQ---VTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGA 282 G A H D+ R + + +A + L A + E + K T Sbjct: 223 LKVEHGTLRAWWQPQAPHPLDEQGRLLERAPAEALAAHLPGAEGHLSELQSKRQTQSAPL 282 Query: 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISD 341 P+ S LQ A+ R K+ + + Q LYE ITY R+D L + + + Sbjct: 283 PYSLSALQVDAARRYKLPAKRVLDICQTLYERHQLITYPRSDCRYLPEGHFAAAKKTLDT 342 Query: 342 NFGKK--------YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQL 393 + S A + AH A+ P+ + D +++L Sbjct: 343 ACAQDATLRGWYQGADFSRRSRAWNDKQVGAHHALAPTGRTF---DASRLTGDEANVFRL 399 Query: 394 IWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAV 453 I R +A +P +A+GR + GW + DE LPA+ Sbjct: 400 IARNVLAQFYSPLVTRDVKAAFSIHGEHFRAQGREILEPGWKPLFTTR---DEAPPLPAL 456 Query: 454 NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR-----------------GIGRPST 496 ++G+A +V+ T+PP F++ASL+K + G+G +T Sbjct: 457 HEGEAARVVDCAVEDRQTRPPDPFTDASLIKAMMNIARYVDDATVKRTLRDTDGLGTEAT 516 Query: 497 YASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANH 556 A I+ T+ RGY+ + A + G + L + + TA E L +A Sbjct: 517 RAGIMETLVTRGYIVRQQGALRATRTGRALIQALPDTA---TRPERTALWEQRLADIAEG 573 Query: 557 EAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTAS 612 + A LD D Q LD+A+ + S R + Sbjct: 574 RGDADAFLDALVGDVRQLLDQADAARMRQALATTGGAEPSSPSRGKKRGTRRGSGD 629 >UniRef50_A4JFS2 DNA topoisomerase III n=4 Tax=Proteobacteria RepID=A4JFS2_BURVG Length = 760 Score = 502 bits (1292), Expect = e-140, Method: Composition-based stats. Identities = 153/784 (19%), Positives = 268/784 (34%), Gaps = 110/784 (14%) Query: 1 MGKALVIVESPAKAKTINKYLGS------DY-----------VVKSSVGHIRDLPTSGSA 43 M + L I E PA A+ I K++G Y +V S +GH+ Sbjct: 1 MKR-LFIAEKPAMARDIAKHMGGRMTKKVGYVEVDMGGGVVNIVASCIGHLLKQAEPADY 59 Query: 44 AKKSADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKA 103 K P + ++ K V+ L++L + Sbjct: 60 VKDL------------------EFPGTFADLPILPDQWKLQIAEKKSAQVTLLRRLLREC 101 Query: 104 DHIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDR 161 D + A D REG+ I L E G R++ N + +++ + Sbjct: 102 DEVVNAGDPGREGQLIIDELLEFCGNR-KPVKRILLNSLDSATVKRELANLQDNTRFKPI 160 Query: 162 VNAQQARRFMDRVVGYMVSPLLWK-----KIARGLSAGRVQSVAVRLVVEREREIKAFVP 216 A R+ D +VG +S + LS GRVQS + LVV R+R I+ FVP Sbjct: 161 YQAGLGRQRADWLVGMNLSRAYTILGRRAQYRGVLSVGRVQSPTLALVVRRDRAIETFVP 220 Query: 217 EEFWEVDASTTTPSGEALALQVTHQN-----DKPFRPVNKEQTQAAVSLLEKARYSVLER 271 ++W V A GE A + D+ R V + + + V + + Sbjct: 221 RDYWAVKALVRVDGGEFWARWKKPEPAPEWLDEEGRIVVQAEAERIVRATQGQTGQITRF 280 Query: 272 EDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLY-EAGYITYMRTDSTNLSQD 330 E KP +P PF +TLQ AS + G+ K+ + Q LY E +Y RTD+ +L Sbjct: 281 ETKPGKEEPLLPFSLATLQIFASAKWGYSAKEVLDACQYLYSEKKCFSYPRTDARHLVVA 340 Query: 331 AVNMVRGYISDNF--------GKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKD 382 + +S S A ++ H A+ P+ A Sbjct: 341 LQAQIPDTLSAIAQTLSMLSPACAKADSSILGKAWDDSKVGEHYALIPTS---EAADFAS 397 Query: 383 MEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPAL- 441 + Q LY+ + ++++ + T++ A GR+++ +GW +V Sbjct: 398 LTPIQQNLYRAVAQRYITLFYPDCLIERTSVEATVAQEVFAASGRVVKSEGWREVYAGEA 457 Query: 442 -------------RKGDEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEK 488 + ++++ P ++ G + + Q TKPP R S++SL+ + Sbjct: 458 PEPETPDANGKVAEEKEDEQRFPQMSLGQSAKAAQTVSEQKRTKPPTRMSDSSLLLAMTN 517 Query: 489 -----------------RGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 +GIG +T A+II + ++G + E + + ++ D L Sbjct: 518 VHQLVKDPQLRQRLQSSKGIGTSATRAAIIENLVEKGLLLREGKTLISSSAARVLIDALP 577 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKD---------- 581 L++ +A EN+LD VA +A + + Q L+KA+ Sbjct: 578 AT---LLDPALSAMWENALDLVAAGKAPLDLFMQKQEAWLRQLLEKAQATGLGALSDAPL 634 Query: 582 PEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENE 641 ++ + + S + P+ Sbjct: 635 ANANAGGASRGSGSGSRAGSSSGGSRSAGTSRSSSGSTASSRSAPQTGAGQNAGSGSRTP 694 Query: 642 VLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDP-----KRKLHVCGNNPTCDGYEIEE 696 + E ++T A + CP+C T + C N P C E Sbjct: 695 APREIGHESSKTAPSAAVKACPECKTGKMVVRQARSGPSAGKPFLGCTNYPRCKHAERMP 754 Query: 697 GEFR 700 + Sbjct: 755 EKEP 758 Score = 44.7 bits (104), Expect = 0.016, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 22/77 (28%), Gaps = 7/77 (9%) Query: 732 TNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSD-AYFVLRDGAAGV-----FLAANT 785 N + R K P + C + V+R +G FL Sbjct: 685 QNAGSGSRTPAPREIGHESSKTAPSAAVKA-CPECKTGKMVVRQARSGPSAGKPFLGCTN 743 Query: 786 FPKSRETRAPLVEELYR 802 +P+ + +E R Sbjct: 744 YPRCKHAERMPEKEPAR 760 >UniRef50_Q5HLZ4 DNA topoisomerase 3 n=9 Tax=Staphylococcus RepID=TOP3_STAEQ Length = 711 Score = 501 bits (1291), Expect = e-140, Method: Composition-based stats. Identities = 152/768 (19%), Positives = 270/768 (35%), Gaps = 110/768 (14%) Query: 3 KALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K+L++ E P+ + I L G Y+V ++GH+ T + Sbjct: 2 KSLILAEKPSVGRDIANALNLQQKSNGYIEGKQYIVTWALGHLVTNATPEQYNPSYKEWN 61 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADHIYLA 109 PK + V+ + +K L + I +A Sbjct: 62 LEDLPIIPK-------------------KMKTVVISKTNRQFKIVKSLILDKNVKEIIIA 102 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQA 167 TD REGE +A + + +G + R+ + +TK AI++ F + + A A Sbjct: 103 TDAGREGELVARLILDKVG-NKKPIKRLWISSVTKKAIQEGFKQLKNGNAYQNLYEAALA 161 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D +VG + L K LS GRVQ+ +++V R+ EI F PE+++ + + Sbjct: 162 RSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQIVKSRQDEINYFKPEKYYTLSINVD 221 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + R +K++ + ++ +LE + K S F + Sbjct: 222 GYDLNLKQQK---------RYKDKKELELIEHKIKHQEGKILEVKGKNKKSYAQPLFNLT 272 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDAVNMVRGYISDNFGKK 346 LQQ A G K+T+ Q LYE +TY RTDS L+ D V+ ++ + Sbjct: 273 DLQQEAYKHYKMGPKETLNTLQHLYERHKLVTYPRTDSNYLTDDMVDTIQERLRAILATD 332 Query: 347 YLPE---------SPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 Y S + H AI P++V S++ + K+Y LI + Sbjct: 333 YKSHVRDLISESFSSKMHIFNNQKVSDHHAIIPTEVRP---SIEQLSQREFKIYMLIAER 389 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 F+ M P Y+ T+ D+ + I + G+ + + + + +G Sbjct: 390 FLENLMNPYLYEVLTIHAQLKDYNFVLKEIIPKQLGYKAL---KDQTSSHTLTHSFKEGQ 446 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEK-------------------RGIGRPSTYA 498 + + +H TK P F+E SL+K +E GIG +T A Sbjct: 447 LFKVHRIEIHEHETKAPEYFNEGSLLKAMENPQNHIDLNDKKYAKTLKHSGGIGTVATRA 506 Query: 499 SIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEA 558 II + + + + + G+ + LE + EL + TAQ E L + + Sbjct: 507 DIIEKLFNMNALESRDGKIKVTSKGKQI---LELSPSELTSPILTAQWEEKLMLIEKGKY 563 Query: 559 EWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLG 618 + + + + ++K + + LT+ +CPTCG+ M G L Sbjct: 564 NSQKFIQEMKNFTFKVVNKI----KSSEQKYKHDNLTTTECPTCGKFMIKVKTKNGQMLV 619 Query: 619 CSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKR 678 C +CKT N+ + RCP C M + + Sbjct: 620 C------QDPKCKTKKNIQR------------------KTNARCPYCKKKMTLFGKGKEA 655 Query: 679 KLHVCGNNPTCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG 726 + + + G + + + F Sbjct: 656 VYRCVCGHTETQSQMDKRMRDKTNGKVSRKEMKKYINKKEEIDNNPFK 703 Score = 43.9 bits (102), Expect = 0.029, Method: Composition-based stats. Identities = 16/127 (12%), Positives = 33/127 (25%), Gaps = 20/127 (15%) Query: 716 SEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKSDAYFVLRDG 775 M ++ G++ + T K++ + + K L C + + Sbjct: 554 KLMLIEKGKYNSQKFIQEMK-NFTFKVVNKIKSSEQKYKHDNLTTTECPTCGKFMIKVKT 612 Query: 776 AAGVFLAANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTMVRFSRKT 835 G L PK + + + + P K M F + Sbjct: 613 KNGQMLVCQ-DPKCKTKKNIQRKTN------------------ARCPYCKKKMTLFGKGK 653 Query: 836 KQQYVSS 842 + Y Sbjct: 654 EAVYRCV 660 Score = 42.4 bits (98), Expect = 0.085, Method: Composition-based stats. Identities = 13/85 (15%), Positives = 22/85 (25%), Gaps = 13/85 (15%) Query: 699 FRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPL 758 + K + EC CG M + G+ + C + +CK K++ Sbjct: 588 QKYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPKCK-------------TKKNIQRK 634 Query: 759 PELPCEKSDAYFVLRDGAAGVFLAA 783 C L Sbjct: 635 TNARCPYCKKKMTLFGKGKEAVYRC 659 >UniRef50_B0EMC7 DNA topoisomerase 3-alpha, putative n=2 Tax=Entamoeba RepID=B0EMC7_ENTDI Length = 607 Score = 501 bits (1290), Expect = e-140, Method: Composition-based stats. Identities = 130/605 (21%), Positives = 243/605 (40%), Gaps = 34/605 (5%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYV----VKSSVGHIRDLPTSGSAAKKSADSTSTKTA 56 M L + E P+ A I+ L S I + K ++ Sbjct: 1 MNSVLHVAEKPSVANAISYTLSRGQCQKTSGLSKYNSIFEFEKEFKNIGKCTHYVTSVAG 60 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHYE--VLPGKEKVVSELKQLAEKADHIYLATDLDR 114 D A + DP + A E V +KV LK +A+K + L D DR Sbjct: 61 HLKGIDFTTAYRSWGSCDPEELFTAPIEKSVPASMKKVELNLKNVAKKCQVLVLWLDCDR 120 Query: 115 EGEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 EGE I++ + EV +++ R FN + + I +A+N N A R+ +D Sbjct: 121 EGENISFEVIEVCSEVNSKMKVWRAHFNSLVPDEIIKAYNTLTAPNRHMSEAVDVRQEID 180 Query: 173 RVVGYMVSPLLWKKI--------ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 G + + + LS G Q + VV+R +IKAF E F++++ Sbjct: 181 LRTGAAFTRFQTTLLKNKSKALEGKVLSYGACQFPTLGFVVDRYYQIKAFTKETFYKINC 240 Query: 225 STTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTSKPGAP 283 S + + ++ F + + LE ++ E +K T+ P Sbjct: 241 VVEKNS---ILTEFHWDRNRLFDRLICD--LLYEDALEHINSATITEILEKSRTNFKPLP 295 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA--VNMVRGY--- 338 T LQ+A S +TM +A++LY +G I+Y RT++ D ++ + Sbjct: 296 LTTVDLQKACSKYFKISSNETMTIAEKLYNSGLISYPRTETNIFPSDMDHEKQIKMFQEN 355 Query: 339 -ISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 I ++ ++ L + + + ++H I P+ +L D+ +K+Y I R Sbjct: 356 RIYSSYVQELLNGKIKNPRNGKATDKSHPPIHPT----RNANLNDLSEKERKIYDFIVRN 411 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 ++A A+ T + + G+ G ++ + + P + D++ +P ++G+ Sbjct: 412 YLANMSDDARGFETKIGLQVGNESFHCNGLMITERNYLNIFPFRKWSDKE--IPEFHEGE 469 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 + L + T PP +E L++ ++K GIG +T A I IQ+R YV V+ F Sbjct: 470 KVQLNCFEVSYGETSPPKPLTEPELIQLMDKNGIGTDATIAQHIQKIQEREYVIVKQGSF 529 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 +G + + + E A+ E L ++ + E+ V+ F + + ++ Sbjct: 530 IPTNLGLALVEGYDSMGFEFSRPQLRAETEKELTKICSGESNKDDVISTFIEQYEELYER 589 Query: 578 AEKDP 582 A+ + Sbjct: 590 AQYNK 594 >UniRef50_B1HX02 DNA topoisomerase III n=93 Tax=Bacillaceae RepID=B1HX02_LYSSC Length = 725 Score = 500 bits (1288), Expect = e-140, Method: Composition-based stats. Identities = 152/747 (20%), Positives = 286/747 (38%), Gaps = 102/747 (13%) Query: 4 ALVIVESPAKAKTIN-----------------KYLGSDYVVKSSVGHIRDLPTSGSAAKK 46 +VI P +A + Y + ++ + GH+ +L T Sbjct: 2 KIVIAAKPDQAAKLAAPWSFTIKTGYFEVKANSYFPNGAIITWATGHLCELKTPEEYDST 61 Query: 47 SADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD-- 104 ++ P Y+V K K + +K L ++AD Sbjct: 62 WKKW-------------------KLETLPIIPDRFEYKVSKSKYKQFTIIKNLVKRADIQ 102 Query: 105 HIYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRV 162 I + D REGE I + V G + R+ + +T+N+++ F+ P D Sbjct: 103 EIIIGGDAGREGELIIRTILRVCG-VNKPMKRLWISSLTENSVKNGFSNLLPEAQTKDIY 161 Query: 163 NAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPE 217 +R D ++G S L + + S GRVQ+ + L+V RE EI F E Sbjct: 162 YEALSRSCADWLIGINTSRLYTVLLKKNGVKDVFSIGRVQTPTLALIVHREHEIANFKSE 221 Query: 218 EFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTT 277 FWEV+A L+ + R + ++Q A + + + + Sbjct: 222 PFWEVEAVFHFAG---KMLKAKWHKNNMSRVLEEKQAIAIANFCLHKNVDITKIIKETKE 278 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 P F S LQ A+ F +KT+ + Q+LY G ++Y R+DS L+ + + Sbjct: 279 YAPPLLFNLSGLQATANKAYKFSPQKTLDILQKLYVKGLVSYPRSDSQFLTSEEAKTLPT 338 Query: 338 YISD----NFGKKYLPESP-----NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQ 388 +++ + K LP N+ E H AI ++ +L + + + Sbjct: 339 ILNNLSKMDKYKNLLPPPINSIMHNKRYVNEKKVTDHHAIIVTEQMP---NLSKLSMEEE 395 Query: 389 KLYQLIWRQFVACQMTPAKYDSTTLTVGAGD-FRLKARGRILRFDGWTKVMPALRKG--- 444 K+Y L+ RQ +A A + TT+ ++G+ +GW KV+ + Sbjct: 396 KIYDLVARQVIAAHYNHAIFAYTTIHSLVDKRAEFISKGKEQIEEGWRKVIYPTKDSSSQ 455 Query: 445 DEDRILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR--------------- 489 +E+ +LP +++ + T+ + + Q T+PP R+SE L+ ++ Sbjct: 456 EEEEMLPLLHENELGTVAQASVKQGATQPPNRYSEGHLITLMKTAGKHLDDAELEKVLSK 515 Query: 490 --GIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQME 547 G+G +T A II T++DR Y+ ++ + +A G ++ + L EN L + TA+ E Sbjct: 516 TEGLGTEATRAGIIGTLKDRQYIEIKKNQVFATSKGMLLIEALGEN-SLLTSPSMTAKWE 574 Query: 548 NSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMG 607 L ++ A +A ++ + + A + + ++ S + P + Sbjct: 575 QRLAEIGEGHASPQAFMEQVKKLTYKLITDAHEREKAWTFDQKEVEKISANNPYQKKYKK 634 Query: 608 IRT------------ASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGE----DA 651 +T G F GCS Y CK +++ ++ ++ Sbjct: 635 EKTVVGKCILCNGSIIDHGTFYGCSNYKA---ANCKFSVSKKILSKTISQTNVRKLLATG 691 Query: 652 ETNALRAKRRCPKCGTAMDSYLIDPKR 678 ET+ ++ ++ K A + R Sbjct: 692 ETDMIKGFKKGQKTFNAHLIWDKQEHR 718 >UniRef50_A1U7T2 DNA topoisomerase I n=2 Tax=Marinobacter RepID=A1U7T2_MARAV Length = 729 Score = 500 bits (1287), Expect = e-139, Method: Composition-based stats. Identities = 224/782 (28%), Positives = 330/782 (42%), Gaps = 82/782 (10%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 MG+ LVIVESPAK+K I LGS+Y V +SVGH+RDLP Sbjct: 1 MGQILVIVESPAKSKKIQTILGSNYRVAASVGHMRDLPPRD------------------- 41 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +GVD + Y V GK +VVS LK+LA +D + LATD DREGEAIA Sbjct: 42 ----------LGVDLETL-KPTYVVSEGKSQVVSNLKRLAGMSDEVILATDPDREGEAIA 90 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 WHL+ + D RV + EIT++AI +A PG +++ V AQ++RR +DR++GY VS Sbjct: 91 WHLKVALRLPDD-VKRVSYQEITRDAIMKAMANPGRIDMKLVAAQESRRVLDRLIGYQVS 149 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALALQVTH 240 P L K LSAGRVQSVAV+ VV+REREI+AF P + + +L +T Sbjct: 150 PALSSKANLSLSAGRVQSVAVKFVVDREREIQAFQPRGYNVCTLRLAGHPNVSASLDMTP 209 Query: 241 QNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFG 300 K R Q R +++ E KP KP + F T LQ A G Sbjct: 210 FVPKDERLWKASDAQPFAG---PQRVKLVKVEKKPNAVKPKSAFTTVDLQGVAGKIFGLS 266 Query: 301 VKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYASKEN 360 K+ M AQ L+E G ITY RTDS NLS + + ++ Y+S + + ++ SK + Sbjct: 267 AKEVMAAAQTLFEQGLITYHRTDSPNLSDEGIAKIQSYLSGQ--GVPIADQVVRHKSKGD 324 Query: 361 SQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAG-- 418 +QEAHEAIRP+DV+ + +Y LI + + M T + Sbjct: 325 AQEAHEAIRPTDVSAATAGQ---TDTEKNVYSLIRERAMLSVMPNGIDAVTQYVFQSERR 381 Query: 419 ---------DFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQH 469 + A+G +++ GW R +D LP + +G + + Q Sbjct: 382 VPGLSGRPVNPMYMAKGSVVQEKGWRAYAKLERIKSKDTPLPLLEQG-RIYDGSVAAVQK 440 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR-----FYAEKMGE 524 T+PP+R++E +L+K LE +GIGRPSTYA I+ I++R Y+ + F K+G Sbjct: 441 TTEPPSRYNEQTLIKALEAKGIGRPSTYAQIMENIKNRSYIEPKPGSGKSPAFVPGKLGY 500 Query: 525 IVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEE 584 + D L M+Y +T +E SLD+VA + ++ T + + Sbjct: 501 YIVDALSRF--SFMSYTYTRAVEASLDKVARGSMSYVGLVRPVSDQLTSDIAE------- 551 Query: 585 GGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLN 644 + + CP C + + + G I+ + Sbjct: 552 --RLEAESLALKGRCPGCDQPIIQKHRKGS---GRGKGRSQGSRAFWVHIDDAHAAACVQ 606 Query: 645 VLEGEDAET--NALRAKRRCPKCGTAMDSYLIDPK--RKLHVC---GNNPTCD-GYEIEE 696 L E CP+C + G+ C + + Sbjct: 607 YLNDEHDAPVLPPPEVTSPCPQCQATLIRRYSKTGSRSPYWAHAERGDGDACGVKFFPDV 666 Query: 697 GEFRIKGYDGPIVECEKCGSEMHLKMGRFG----KYMACTNEECKNTRKILRNGEVAPPK 752 + P +C CG M + C N +G A Sbjct: 667 DGQPVIPEPIPETKCVDCGGIMKKRKNSKTQQPVWVHVAKKPSCGNLFIDDIDGVPANAA 726 Query: 753 ED 754 + Sbjct: 727 KK 728 >UniRef50_C7DGI7 DNA topoisomerase n=1 Tax=Candidatus Micrarchaeum acidiphilum ARMAN-2 RepID=C7DGI7_9EURY Length = 727 Score = 499 bits (1285), Expect = e-139, Method: Composition-based stats. Identities = 166/710 (23%), Positives = 276/710 (38%), Gaps = 64/710 (9%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K L+I E P+ A I LG+ G I + + +K Sbjct: 2 KTLIIAEKPSVALRIAIALGNGQHKSVRNGRITYYTMPHGDGEIYVAAAVGHLFTIRQKG 61 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLPG---KEKVVSELKQLAEKADHIYLATDLDREGEAI 119 + A W Y ++ + LK+LA++ A D D EG I Sbjct: 62 KERAYPIT-----EIEWAPSYLTNKRSEYTKEYLFTLKKLAQECSTFINACDYDIEGTVI 116 Query: 120 AWHLREVIGGDDARY-----SRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRV 174 ++ + + G A R+ F+ T + +F +I+ A +AR +D + Sbjct: 117 GTNIIKELSGLQAEAIGSVSKRMKFSTTTPKDLLDSFGSLLPPDINNFYAGEARHMLDWL 176 Query: 175 VGYMVSPLLWKKIA-----RGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 G S L ++ + LS GRVQ A+ L+ +RE+EI +F PE +W V A Sbjct: 177 WGINFSRALTSALSSSGQYKQLSIGRVQGPALGLLAKREKEIASFKPEPYWNVLAY---- 232 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTL 289 SGE + + F E +A + V E +P PF ++L Sbjct: 233 SGEF---EFINSRGNIFAKQEAESAFSAANSGRD-NAVVSEATSAEQLRRPYPPFDLTSL 288 Query: 290 QQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA------VNMVRGYISDNF 343 Q AS GF T+ MAQ LYE +I+Y RT S L + ++ + Sbjct: 289 QLEASRVFGFDPSATLAMAQSLYERSFISYPRTSSQKLPRTLGLPRIIADLGKNPAYSTI 348 Query: 344 GKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQM 403 + + A EAH AI P+ V K + +KLY LI R+F++C Sbjct: 349 AAEIASKGRFTPAEGPKEDEAHPAIFPTGVTP-----KGITGSEEKLYDLIARRFLSCFG 403 Query: 404 TPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVE 463 AK ++ +L + G + +G + + GW + + D LP + KG + + + Sbjct: 404 EYAKVNNFSLEISIGGETFEGKGSKVTYPGWLDYYKYAKIKERD--LPNLEKGQRVEITD 461 Query: 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMG 523 + + T PP RF++A L+ ELEK +G +T A+II T+ R Y+ + G Sbjct: 462 IKMPELQTAPPKRFTKAGLISELEKHNLGTKATRAAIIDTLFKRNYIE--GSSIRVTEFG 519 Query: 524 EIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPE 583 V D LE+N +++ D T +E +D ++ + VL ++ + E Sbjct: 520 MTVYDALEKNCSMIVDEDTTITLEKDMDLISKGKMPESEVLKKGKEVLLTAIETFNSNKE 579 Query: 584 EGGMRPNQMVLTS---IDCPTCGRKMGIRTASTGV-FLGCSGYALPPKERCKTTINLVPE 639 + + ++ CP G + I+ + G F+ CS Y +C T L Sbjct: 580 KISEEMKESFKSANVLGKCPKDGGDLVIKRSFRGKQFVACSNYP-----KCTNTYPLPQN 634 Query: 640 NEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTC 689 +++ C C T + +I + +P C Sbjct: 635 AKIVP-------------TGNACEFCHTPIV-KIIRRGKPPFEIDLDPNC 670 Score = 47.0 bits (110), Expect = 0.003, Method: Composition-based stats. Identities = 21/148 (14%), Positives = 40/148 (27%), Gaps = 19/148 (12%) Query: 688 TCDGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGE 747 C E+ ++ I + + SE+ + GK + T E Sbjct: 529 NCSMIVDEDTTITLEKDMDLISKGKMPESEVL----KKGKEVLLTAIE--TFNSNKEKIS 582 Query: 748 VAPPKEDPVPLPELPCEKSDAYFVLRDGAAGV-FLAANTFPKSRETRAPLVEELYRFRDR 806 + C K V++ G F+A + +PK T Sbjct: 583 EEMKESFKSANVLGKCPKDGGDLVIKRSFRGKQFVACSNYPKCTNTYP------------ 630 Query: 807 LPEKLRYLADAPQQDPEGNKTMVRFSRK 834 LP+ + + + + R Sbjct: 631 LPQNAKIVPTGNACEFCHTPIVKIIRRG 658 >UniRef50_C4L3B0 DNA topoisomerase n=2 Tax=Exiguobacterium RepID=C4L3B0_EXISA Length = 708 Score = 499 bits (1285), Expect = e-139, Method: Composition-based stats. Identities = 163/697 (23%), Positives = 281/697 (40%), Gaps = 105/697 (15%) Query: 5 LVIVESPAKAKTINK-----------------YLGSDYVVKSSVGHIRDLPTSGSAAKKS 47 L+I E P++A+ + +V +VGH+ +L + Sbjct: 3 LIIAEKPSQAQKLAAPYPSKKRKEEIEISPCPRFPEGAIVVWAVGHLCELQEPSHYRPEW 62 Query: 48 ADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLA--EKADH 105 P+ Y + GK K +K+ Sbjct: 63 KSWKYEALPIVPE-------------------RFDYRISKGKSKPFYAIKKWLHDRSITD 103 Query: 106 IYLATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVN 163 + +A+D +REGEAI + + G + +R+ + +T+ A+ + F++ PGE I + Sbjct: 104 VIIASDAEREGEAIVRLILRLAG-NKKPLARLWISSLTEQAVDRGFSQLLPGEQTIPYYH 162 Query: 164 AQQARRFMDRVVGYMVSPLLWKKIAR-----GLSAGRVQSVAVRLVVEREREIKAFVPEE 218 +R D +VG S + S GRVQ+ + L+V REREIK FVPE Sbjct: 163 EAMSRACADWLVGMNASRAYTTLLKTIGIEDVFSLGRVQTPTLALIVNREREIKQFVPEP 222 Query: 219 FWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTS 278 ++EV+A+ G + + K + +E+ A V V + + Sbjct: 223 YFEVEATLAKGRGTF---KAKYTFGKTTKLKTREEADAVVKRASG-TAIVKTIDKEEKIE 278 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-----VN 333 +P F S LQ A R GFG KKT+ +AQ+LY G+I+Y RTDS ++ D Sbjct: 279 QPPFWFSLSGLQAEAGKRFGFGAKKTLDIAQKLYTKGWISYPRTDSGFVTPDEATLFPQT 338 Query: 334 MVRGYISDNFG--KKYLPESP--NQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQK 389 R SD + + L E P N+ H AI P++ + + D K Sbjct: 339 KARLLKSDAYAGLRDLLTEDPSKNRRYVNAKKVSDHYAIIPTEA---CGDVTRLGGDEAK 395 Query: 390 LYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRI 449 LY LI R+F+A A + TT+ + G +A+G ++ G+ +V+ +D Sbjct: 396 LYDLINRRFLAAFAPAAMLEKTTVDLIDGGDLYRAKGTVVVSPGYRQVV---EMKSKDVE 452 Query: 450 LPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIG 492 LPA+ G+ ++ T+PP R++E +L+ + E G+G Sbjct: 453 LPALTVGEEFKEKKVEVLSKQTEPPKRYTEGALIMAMKVAGKQLDDEELIHIMKEVEGLG 512 Query: 493 RPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQ 552 +T A+II ++ RGYV+++ + G ++ D L ++ L + TA+ E L + Sbjct: 513 TEATRANIIDGLKKRGYVQLQKKELVPTDKGRLLIDVLGDSI--LASPVMTAKWEKRLHE 570 Query: 553 VANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN-------------QMVLTSIDC 599 + A ++ +++A+ E + + C Sbjct: 571 IGQASASAAEFIEQAKKMSVHLVEEAKSRVEAANPEGYTIEAKRYGKKGTTRPKASFGIC 630 Query: 600 PTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINL 636 P CG+ + F+GCSGY +E C+ T++ Sbjct: 631 PNCGKGLVE----HPKFIGCSGY----REGCRFTVSK 659 >UniRef50_Q099E1 Topoisomerase B n=1 Tax=Stigmatella aurantiaca DW4/3-1 RepID=Q099E1_STIAU Length = 1504 Score = 498 bits (1281), Expect = e-139, Method: Composition-based stats. Identities = 129/667 (19%), Positives = 234/667 (35%), Gaps = 114/667 (17%) Query: 6 VIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTSTK 54 V+ E PA A+ I + LG + YVV ++GH+ L + Sbjct: 33 VVAEKPAVARDIARALGATQRGEGWFRGNGYVVTWAIGHLVGLAQPHEMHPAWKRWHREQ 92 Query: 55 TAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQL--AEKADHIYLATDL 112 P V ++ + A + + ATD Sbjct: 93 LPMLPST-------------------WPLVVSENTRTQFEVVRAVVNAPEVSGVVCATDA 133 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 REGE I ++ E G R+ + +T+ AIR+ F + +A + R Sbjct: 134 GREGELIFRYIYEAAGCR-KPVKRLWVSSLTEGAIREGFRTLKDGRAYDALADAAKGRSR 192 Query: 171 MDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT--- 227 D +VG +S L LS GRVQ+ + ++VERE I+ FVPE++ EV A+ Sbjct: 193 ADWLVGMNLSRLYTLACGETLSVGRVQTPTLAMLVERELAIRDFVPEDYLEVVATFAPQA 252 Query: 228 ---TPSGEALALQVTHQNDKPF------------RPVNKEQTQAAVSLLEKARYSVLERE 272 + K P + + ++ + + Sbjct: 253 AGVPAGTQYRGTWFREAEPKGGPRTAETAREARRLPADGVEAGEVMARVRSGAAVIESLT 312 Query: 273 DKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY-ITYMRTDSTNLSQDA 331 + P + + LQ+ A+ GF ++T+ +AQ LYE ++Y RT S +LS Sbjct: 313 SETKRMAPPLLYDLTELQRHANRLYGFSAQRTLELAQNLYEKHKLLSYPRTASRHLSSAV 372 Query: 332 VNMVRGY---ISDNFGKKYLPESPNQY----ASKENSQEAHEAIRPSDVNVMAESLKDME 384 + I + P + + + H AI P+ + E + Sbjct: 373 AETLPEVVRAIRAPYEPLLAPGTGEKPLGRRFVDDAKVTDHHAIIPTATSPEGE---RLP 429 Query: 385 ADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDF----------RLKARGRILRFDGW 434 D ++LY+L+ R+ +A + TT+ R + G + GW Sbjct: 430 PDEKRLYELVCRRLLAAWHDEHVWAVTTVVTAVSSVGPAPGSPRVDRFHSSGTQVVRVGW 489 Query: 435 TKV--------------------MPALRKGDEDRILPA-VNKGDALTLVELTPAQHFTKP 473 + DE + LPA + +G + ++ + T+P Sbjct: 490 KVLDIGGGQRPPKGREGKGPKEEGEGKEPEDEPQDLPAVLARGQKQRVEDVEAVKKRTRP 549 Query: 474 PARFSEASLVKELE----------------KRGIGRPSTYASIISTIQDRGYVRVENRRF 517 P R ++ASL+ +E + G+G P+T A+II + +R Y++ + Sbjct: 550 PPRLTDASLLTAMETAGRTLDEKELADAMKETGLGTPATRAAIIEVLLEREYLQRRGKSL 609 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 + G + + ++ T Q E L ++ + + +A L + + + K Sbjct: 610 EVTEKGIRLIQVVH---PDVKTPAMTGQWEAWLQRIERGQGDLQAFLRGIEAYVIEVVGK 666 Query: 578 AEKDPEE 584 P Sbjct: 667 MPAQPMP 673 >UniRef50_C6XWV5 DNA topoisomerase type IA central domain protein n=2 Tax=Pedobacter RepID=C6XWV5_PEDHD Length = 608 Score = 497 bits (1279), Expect = e-139, Method: Composition-based stats. Identities = 141/617 (22%), Positives = 237/617 (38%), Gaps = 63/617 (10%) Query: 4 ALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 +VI E P+ + + K G Y + GH+ L Sbjct: 2 KIVIAEKPSVGRELAKVFGATTKKDGYIEGKGYSFTWAFGHLLQLAPPQEYG--FIGWRR 59 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 PKK + + PG K + +K+L ++A I +ATD Sbjct: 60 QHLPMLPKKFKLAIRKIKTKD--------GMVEDPGVRKQLDIIKKLFDEATEIIVATDA 111 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGE--LNIDRVNAQQARRF 170 REGE I ++ + + R+ + T AI++ F N+ R Sbjct: 112 GREGELIFRYIYYFLKC-KKPFRRLWISSQTDEAIKEGFRNLKPGTDYDTLFNSAHCRSE 170 Query: 171 MDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTT 228 D +VG + L LS GRVQ+ + ++ R EIK FVP+ ++++ Sbjct: 171 SDWLVGMNATQALSISAGNRSVLSLGRVQTPTLAMICSRFLEIKNFVPQTYYQLAIQLDK 230 Query: 229 PSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITST 288 A+ V++ + K + + S +L E KP P S+ Sbjct: 231 DGQLFRAMSVSNFDKKEEAEELLAKIEDVASGFSNG-GKILSVEAKPRKEPPPLLHDLSS 289 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYIS-----DNF 343 LQQ A+ R GF +T+ + Q LYE+ +TY RT S + D V I +F Sbjct: 290 LQQEANKRKGFTADQTLSLLQGLYESKLVTYPRTGSRYIGDDIFAGVPALIDKVRGHKDF 349 Query: 344 GKK---YLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVA 400 GK+ L N+ + H AI P+ ES + D Q +Y ++ + + Sbjct: 350 GKQAEFLLTVPLNKRSVNAKKVTDHHAILPTG-----ESPYQLNGDKQAVYDMVVGRMIE 404 Query: 401 CQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM---PALRKGDEDRILPAVNKGD 457 + T ++V +G A G ++R GW V +K +++ LP + KG+ Sbjct: 405 AFHQECVKEITKISVESGS-LFIANGTVIRAAGWRSVFNESDEEKKDEDNPALPKLKKGE 463 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVK----------------ELEKRGIGRPSTYASII 501 L + + TKP A ++EASL+K ++ G+G P+T A+II Sbjct: 464 ELPVTNKALLEKQTKPKAMYNEASLLKALETSGKDIEDEELRYAMKDSGLGTPATRAAII 523 Query: 502 STIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWK 561 T+ R YV E R G V D +++ +++ + T Q E L+++ + A Sbjct: 524 ETLISREYVSREKRNLVPTTKGLAVYDVVKD--QKIAQAELTGQWEKRLEEIRSG-ASVS 580 Query: 562 AVLDHFFSDFTQQLDKA 578 ++ Sbjct: 581 DFKAEIADYTKTITNEL 597 >UniRef50_C9LWM4 DNA topoisomerase n=1 Tax=Selenomonas sputigena ATCC 35185 RepID=C9LWM4_9FIRM Length = 714 Score = 496 bits (1278), Expect = e-138, Method: Composition-based stats. Identities = 144/760 (18%), Positives = 271/760 (35%), Gaps = 109/760 (14%) Query: 2 GKALVIVESPAKAKTINKYL--------GSD------YVVKSSVGHIRDLPTSGSAAKKS 47 K + I E P + + YL G V + GHI + T ++ Sbjct: 4 KKTVYIAEKPDIGRAVAAYLWPDGGMEKGKGCFRKGDIAVTWAFGHILGMATPELYGEEY 63 Query: 48 ADSTSTKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIY 107 ++ P + P K++ + +K L + AD + Sbjct: 64 KVWSNY---------------------PILPSTWLMKPDPQKKEQLDIIKGLIKDADVVV 102 Query: 108 LATDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGEL--NIDRVNAQ 165 A D DREG+ + + + + R++ N ++++AF + A Sbjct: 103 HAGDPDREGQLLIDEILDFLH-YKGEVRRILINAKDDESLKRAFASLRDNKDFYGLYEAG 161 Query: 166 QARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFW 220 R D ++G +S + GRV+ + LVV+RE++I +F P++++ Sbjct: 162 LGRARADWLIGMNLSRAYTVNARKAGHDGTYRIGRVKVPTLALVVQREKDILSFKPKKYY 221 Query: 221 EVDASTTTPSGEALALQVTHQN---DKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTT 277 + A +N D+ R ++ QA +EKA + + Sbjct: 222 VLQGIFAYKGVPFTATLEPSENIPLDEEGRVLDVNLLQAIKLKVEKAEGVIRDVATSEGK 281 Query: 278 SKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRG 337 P P+ TLQ A+ G+ ++ + Q+LYE ++Y R+D + V Sbjct: 282 QYPPLPYSLDTLQIEANKIWGYSPQEVLETVQKLYERKLVSYPRSDCNYIPASQREDVPR 341 Query: 338 YISDNF-----GKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQ 392 ++ G A + AH AI P+ + +DM +++Y Sbjct: 342 ILAALKEMDVQGAAGANVDIESKAFNDGKITAHHAIIPTGIRP-----EDMNEQEERIYG 396 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPA 452 +I ++++ P +++ TT ++ GD G+I+R G+ +V + + LP Sbjct: 397 MISKRYIIQFYPPHEFEKTTFSLQVGDEMFSGSGKIIRKMGFREVEREEEEQEGTPRLPD 456 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKEL------------------EKRGIGRP 494 GD + + + TKPP RF+E +L+ + E +GIG P Sbjct: 457 FAVGDKIAKGDYSILNKKTKPPKRFTEGTLIAAMTNIWKFMKADNPNREKMKEVKGIGTP 516 Query: 495 STYASIISTIQDRGY--------VRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQM 546 +T +II+ +Q ++ + G + + + L D TA+M Sbjct: 517 ATRDTIIAELQATSLKGKAVEPCLKKVKKELLPTPFGISLIENVS---PSLAVPDTTAEM 573 Query: 547 ENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKM 606 E +LD++A+ + +D +S + + AEK P CP C + Sbjct: 574 EYALDEIAHGKGNLSDYMDDVYSMVHENIQFAEKHL-----FPLPKDKKRTPCPICREGI 628 Query: 607 GIRTASTG---VFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNALRAKRRCP 663 +R S F CS E+C + P+ + E CP Sbjct: 629 LLRKYSQKSKMYFHMCSN------EKC-----VSPDTGRKMFYPDDSGEP----VVAFCP 673 Query: 664 KCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEGEFRIKG 703 +C + + L +C + + + Sbjct: 674 EC-ETVLAKLNGKNGAFWLCNHCKKTFDDKNGHPVLKKDK 712 Score = 50.5 bits (119), Expect = 3e-04, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 28/102 (27%), Gaps = 7/102 (6%) Query: 690 DGYEIEEGEFRIKGYDGPIVECEKCGSEMHLKMGRFG---KYMACTNEECKNTRKILRNG 746 + + E D C C + L+ + C+NE+C G Sbjct: 600 ENIQFAEKHLFPLPKDKKRTPCPICREGILLRKYSQKSKMYFHMCSNEKC----VSPDTG 655 Query: 747 EVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPK 788 +D C + + +G G F N K Sbjct: 656 RKMFYPDDSGEPVVAFCPECETVLAKLNGKNGAFWLCNHCKK 697 Score = 45.1 bits (105), Expect = 0.012, Method: Composition-based stats. Identities = 18/115 (15%), Positives = 34/115 (29%), Gaps = 4/115 (3%) Query: 641 EVLNVLEGEDAETNALRAKRRCPKCGTAMDSYL--IDPKRKLHVCGNNPTCDGYEIEEGE 698 E + E + + CP C + K H+C N + Sbjct: 600 ENIQFAEKHLFPLPKDKKRTPCPICREGILLRKYSQKSKMYFHMCSNEKCVSPDTGRKMF 659 Query: 699 FRIKGYDGPIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKE 753 + + + C +C + + G+ G + C + CK T V + Sbjct: 660 YPDDSGEPVVAFCPECETVLAKLNGKNGAFWLCNH--CKKTFDDKNGHPVLKKDK 712 >UniRef50_A2QNT8 DNA topoisomerase n=36 Tax=Leotiomyceta RepID=A2QNT8_ASPNC Length = 629 Score = 496 bits (1278), Expect = e-138, Method: Composition-based stats. Identities = 125/635 (19%), Positives = 233/635 (36%), Gaps = 48/635 (7%) Query: 3 KALVIVESPAKAKTINKYLGSD-YVVKSSVG--HIRDLPTSGSAAKKSADSTSTK---TA 56 + L + E PA AK + ++L + + G ++++ + + T Sbjct: 5 RVLCVAEKPAIAKAVAQHLSGGSFQTIAIRGNQYVKNYVFDFNFGGSWGTCSVTMTSVIG 64 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHY--EVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 D + P +EA V K + +++ A + +++ TD DR Sbjct: 65 HLTGLDFERQYRTWLSCPPSALFEAPVHESVADDKVAIAKNIQEQARRCKALFIWTDCDR 124 Query: 115 EGEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 EGE I +R+ ++R R F+ K + A EL+ + NA AR +D Sbjct: 125 EGEHIGTEIRKQAKEGNSRIVVKRARFSNTEKAHVLHAARSLIELDDLQANAVAARIELD 184 Query: 173 RVVGYMVSPLLWKKIARG--------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDA 224 +G + L ++ +S G Q + VV+R +K F PE FW + Sbjct: 185 LRIGAAFTRLQTLQLKPLSAALQDTIISYGSCQFPTLGFVVDRYLRVKNFKPETFWGIKV 244 Query: 225 STTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPF 284 T + L + T L + V + KPT+ P Sbjct: 245 MHTRDDIKVNFLW-----KRVHLFDRVAVTVMLERCLMAKKAKVTKVTQKPTSKWRPLPL 299 Query: 285 ITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQ--DAVNMVRGYI--- 339 T LQ S L + M +A+ LY G+I+Y RT++ + D +V + Sbjct: 300 TTVDLQMMGSRYLRMDSQTIMKVAEALYTKGFISYPRTETDQFDKGIDLKKLVETQLPDG 359 Query: 340 -SDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQF 398 + + L + S ++ +AH I P + + AD +K+Y+ + R+F Sbjct: 360 NWGQYARHLLDGAFKTPRSGRHNDQAHPPIHPICWV----APTALTADEKKVYEFVVRRF 415 Query: 399 VACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDA 458 +AC AK ST + + GD A+G ++ + V + + + LP G+ Sbjct: 416 LACCSEDAKGQSTEIEIQYGDEFFHAKGLLVLERNYLDVYVYDKW-ESSQQLPNYQMGEM 474 Query: 459 LTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVEN---- 514 E T PP +E L+ ++ GIG +T A I+ I++R YV V + Sbjct: 475 FEPTEAKIFDGKTSPPNYLTEPELIGLMDANGIGTDATMAEHIAKIKERQYVAVHSRGSG 534 Query: 515 ----RRFYAEKMGEIVTDRLEENF------RELMNYDFTAQMENSLDQVANHEAEWKAVL 564 + ++G + + + F L +ME + ++ + V+ Sbjct: 535 RNAVKELIPTRLGIALVEGYDNVFAGIPDSPSLSKPFLRKEMELRMREICAGRRTRQQVV 594 Query: 565 DHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDC 599 + + ++ + ++ Sbjct: 595 QESLDMYREVFVHTQRRINRLKDACRKYLVEQETS 629 >UniRef50_O61660 DNA topoisomerase 3 n=2 Tax=Chromadorea RepID=TOP3_CAEEL Length = 759 Score = 496 bits (1278), Expect = e-138, Method: Composition-based stats. Identities = 141/604 (23%), Positives = 246/604 (40%), Gaps = 43/604 (7%) Query: 1 MGKALVIVESPAKAKTINKYLGSD----YVVKSSVGHIRDLPTSGSAAKKSADSTSTKTA 56 M +AL + E AK + L + +S I L T +++A S ++ + Sbjct: 1 MKRALFVAEKNDVAKGVAAILSNGTANRREGRSKFNKIYTLNT-ELFGQQTAISVTSVSG 59 Query: 57 KKPKKDERGALVNRMGVDPWHNWEAHY--EVLPGKEKVVSELKQLAEKADHIYLATDLDR 114 + N + A V P + + L++ A++ D + + TD DR Sbjct: 60 HMMNFQFHENMSNWQTASMVELFRAPVRHVVTPEMKLIEQTLREQAQRHDILVVWTDCDR 119 Query: 115 EGEAIAWHLREVIGGDDAR--YSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMD 172 EGEAI + +V + R R F+EITK AI +A L+ V A R +D Sbjct: 120 EGEAIGAEIVKVCRDSNRRLDIFRARFSEITKAAITRAARNLIRLDEKTVAAVDCRSELD 179 Query: 173 RVVGYMVSPLLWKKIA-------------RGLSAGRVQSVAVRLVVEREREIKAFVPEEF 219 +G + L + + +S G Q + V +R + I+ FV E F Sbjct: 180 LRIGSAFTRLQTLHLRNRFRDLLGQNDTSQVISYGSCQFPTLGFVTDRYKMIENFVSEPF 239 Query: 220 WEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEK-ARYSVLEREDKPTTS 278 W++ T S + L R +++ ++ V + KP + Sbjct: 240 WKLIVEHTRESHKVEFLW------DRNRLFDRDTVDILHDECKETKEAHVEKVAKKPKSK 293 Query: 279 KPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDST------NLSQDAV 332 T L++ ++L K+TM +A++LY G+I+Y RT++ NL+ Sbjct: 294 WRPQALDTVELEKLGISKLRMSAKQTMQVAEKLYSKGFISYPRTETNKFPAGLNLTPLVQ 353 Query: 333 NMVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQ 392 + I +F + L N + S EAH I P ++ D K+Y+ Sbjct: 354 QQTQSNIWGDFANEVLQNGVN-PRNGRKSDEAHPPIHPLKFTEK----HQLQGDDWKVYE 408 Query: 393 LIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPA 452 L+ R F+AC A+ + T + + G + A G +R G+ KV + G +R+LP Sbjct: 409 LVVRHFLACVSQDAQGEETMVNLTVGTEKFHASGLRIRDMGYLKVYVYEKWG--NRLLPT 466 Query: 453 VNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRV 512 +G+ T EL T+ P +EA L+ ++K GIG +T+A I I+ R Y+ V Sbjct: 467 YTEGERFTDFELKIGDGKTQAPDFLTEADLISLMDKYGIGTDATHAEHIEKIKTREYIGV 526 Query: 513 E-NRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDF 571 + + +G + D ++ + D A +E L ++ + + + VLD + Sbjct: 527 RPDGKLIPSFLGLALVDGYDDMGFAMSKPDLRANLEIGLKEICDGRRQKQEVLDEQIGKY 586 Query: 572 TQQL 575 Sbjct: 587 RAIF 590 >UniRef50_A8U7S1 DNA topoisomerase n=2 Tax=Lactobacillales RepID=A8U7S1_9LACT Length = 701 Score = 495 bits (1275), Expect = e-138, Method: Composition-based stats. Identities = 160/744 (21%), Positives = 283/744 (38%), Gaps = 99/744 (13%) Query: 3 KALVIVESPAKAKTINKYLG-----------SDYVVKSSVGHIRDLPTSGSAAKKSADST 51 K L+I E P+ K I + LG D +V ++GH+ L K+ A Sbjct: 12 KTLIIAEKPSVGKEIARVLGATQKSKTHIEGKDVIVTWALGHLLGLKMPEEYKKEWATW- 70 Query: 52 STKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKAD--HIYLA 109 + P + L + +KQLA++ D +A Sbjct: 71 ------------------DLNTLPLIPEKMLTTPLKNTRSQLKAIKQLADRKDIGSAVIA 112 Query: 110 TDLDREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNK--PGELNIDRVNAQQA 167 TD REGE +A + E + + R+ + T AI++ FN+ P + ++ A Sbjct: 113 TDAGREGELVARWILEYVHF-NKPIKRLWISSQTDKAIKEGFNQLQPSKKYDTLYDSAVA 171 Query: 168 RRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTT 227 R D ++G V+ L K LSAGRVQ+ + +V ++E +I++FVPE F+ V Sbjct: 172 RSEADWLIGLNVTRALTVKYQDSLSAGRVQTPTLAMVRKQEAKIQSFVPETFYTVQLVID 231 Query: 228 TPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITS 287 + T Q+ + +++ + V+ L+ V E ++K + + P+ + Sbjct: 232 GK-------KATIQDSALRKFSERQKAEDLVASLKNKSVIVKEIKEKQSIQQAPLPYDLT 284 Query: 288 TLQQAASTRLGFGVKKTMMMAQRLYEAGYI-TYMRTDSTNLSQDAVNMVRGYIS--DNFG 344 LQ+ A+ R F KKT+ + Q LYE + +Y RTDS L+QD + ++ ++ NF Sbjct: 285 ELQREANLRYQFSAKKTLSLMQTLYERHKVLSYPRTDSKYLTQDMIGTMKERVAAIQNFA 344 Query: 345 KKYLPESPNQYAS-------KENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQ 397 + + A H I P++ E MEAD K+Y+++ + Sbjct: 345 PDEVKGILKRGAQVTQKGVFNTAKVTDHHGIIPTEERPRPE---KMEADELKIYRMVVER 401 Query: 398 FVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGD 457 F+ + TT+ A + + GW K + + + Sbjct: 402 FIGLFLPAYNVSKTTIVFSAATTLFSLQQEEVIEKGWKKEVQKQSEKG-------YQLNE 454 Query: 458 ALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRF 517 LT T T+ PAR SE +L++ +EK G+G P+T A II + + + Sbjct: 455 QLTQPTYTIQMQLTEAPARLSEGTLLQNMEKNGLGTPATRAEIIEKLIKSDLMERNQNKL 514 Query: 518 YAEKMGEIVTDRLEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDK 577 G+ + + L+ + T + E +L+++A + + L ++ + + + Sbjct: 515 STTPKGQQLLTLVN---PALVTPELTRKWEEALEEIAKGTLKKEVFLKQIKNETARLVTE 571 Query: 578 AEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLV 637 + E LT+ CP CG + R+ G L CS K R Sbjct: 572 IKNSTETYK----DHALTTKICPDCGELLKERSGRDGKMLICSSTTCSYKRR-------- 619 Query: 638 PENEVLNVLEGEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDGYEIEEG 697 + + RC +C M+ + N C I E Sbjct: 620 ---------------KDPKVSNHRCAQCHRKMEIHEGKNG-------NYFKCKYCNITEK 657 Query: 698 EFRIKGYDGPIVECEKCGSEMHLK 721 E K +++ + Sbjct: 658 IEGKSSKKPSKHETSKLMKKINKQ 681 Score = 59.3 bits (142), Expect = 7e-07, Method: Composition-based stats. Identities = 15/112 (13%), Positives = 35/112 (31%), Gaps = 17/112 (15%) Query: 707 PIVECEKCGSEMHLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVPLPELPCEKS 766 C CG + + GR GK + C++ C R+ + C + Sbjct: 585 TTKICPDCGELLKERSGRDGKMLICSSTTCSYKRRKDPK------------VSNHRCAQC 632 Query: 767 DAYFVLRDGAAGVFLAANTF-----PKSRETRAPLVEELYRFRDRLPEKLRY 813 + +G G + + + ++ P E + ++ ++ Sbjct: 633 HRKMEIHEGKNGNYFKCKYCNITEKIEGKSSKKPSKHETSKLMKKINKQEEV 684 >UniRef50_Q5UQB5 DNA topoisomerase 1 type prokaryotic n=1 Tax=Acanthamoeba polyphaga mimivirus RepID=TOP1P_MIMIV Length = 854 Score = 495 bits (1274), Expect = e-138, Method: Composition-based stats. Identities = 231/865 (26%), Positives = 365/865 (42%), Gaps = 139/865 (16%) Query: 1 MGKALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPK 60 M L+++ESP K I+ LG +YVVK+S+GH RDL Sbjct: 1 MS-ILILLESPGKISKISSILGKNYVVKASMGHFRDL----------------------- 36 Query: 61 KDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIA 120 +M +D +++E Y V K VV LK + D +YLA D DREGEAIA Sbjct: 37 ------DPKKMSIDFDNDFEPVYIV--TKPDVVKNLKSAMKNIDLVYLAADEDREGEAIA 88 Query: 121 WHLREVIGGDDARYSRVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 L +V+ + Y R+ FN ITK+AI A G+++ + V+AQ+ARR +DR+ GY++S Sbjct: 89 QSLYDVLKPSN--YKRLRFNAITKDAIMSAIKNAGDIDKNLVDAQKARRVLDRLFGYLIS 146 Query: 181 PLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEE----FWEVDASTTTPSGEALAL 236 P+L ++I LSAGRVQSV VR+++++E EIK F+ + +++V + Sbjct: 147 PILQRQIGGKLSAGRVQSVTVRIIIDKENEIKNFINKNADSSYFKVSGTFNGAKATLHES 206 Query: 237 QVTHQNDKPFRPVNKEQTQAAV-------------SLLEKARYSVLEREDKPTTSKPGAP 283 D K A + K+++ + EDK TT P P Sbjct: 207 NDKKPFDLETAYKGKTAQIALINSENPNSKVVNFMKRCLKSQFFIHSVEDKMTTRSPAPP 266 Query: 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNF 343 F TSTLQQ A+ + G + TM AQ+LYE GYITYMRTDS +S + ++ I+D + Sbjct: 267 FTTSTLQQEANRKFGMSIDSTMKTAQKLYEGGYITYMRTDSVEISAEGHRDIKKIITDQY 326 Query: 344 GKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQM 403 G Y ++ NSQEAHEAIRP+ ++ + +A KLY+LIW++ +A QM Sbjct: 327 GADYYQKNL-YKNKAANSQEAHEAIRPTHPELLTLEGEIEDAYQIKLYKLIWQRTIASQM 385 Query: 404 TPAKYDSTTLTVGAGDFR---------LKARGRILRFDGWTKVM-PALRKGDEDRILPAV 453 PAK T + + + +++ + F G+ KV ++ D D + Sbjct: 386 KPAKIKVTIIQISISKYVEDKLNPFYYFQSQIETVVFPGFMKVYVESIDDPDTDNQITKN 445 Query: 454 ------NKGDALTLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDR 507 G +T+ E+ Q + +PP R+SEASLVK+LE+ GIGRPSTY + I TI +R Sbjct: 446 FTGKIPTVGSKVTMEEIIARQEYMRPPPRYSEASLVKKLEELGIGRPSTYVNTIKTIINR 505 Query: 508 GYVR-------------------------------------VENRRFYAEKMGEIVTDRL 530 YV+ EN++ +G V D L Sbjct: 506 EYVKITDVPGIKKDITIYSIKSENKKHIMEVYEDTDTILLGKENKKIVPTNLGITVNDFL 565 Query: 531 EENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPN 590 + F E ++Y FTA ME LD V+ W ++ F+ +D+ K Sbjct: 566 MKYFPEFLDYKFTANMETDLDYVSTGTKNWVDIVQDFYDKLKPIVDELSKQKGLSQSSER 625 Query: 591 QMVLTSIDCPTCGRKMGIRTASTGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGED 650 + + G ++ G + K K + + L+ ++ D Sbjct: 626 LLGEDN-----DGNEITATKTKFGPVV-------RKKIGDKYVYAKIKDPLTLDTIKLSD 673 Query: 651 AETNALRAKRRCPKCGTAMDSYLIDPKRKLH----------VCGNNPTCDGYEI-EEGEF 699 A K D L + ++P + + Sbjct: 674 AIKLLEYPKNLGQY--KGFDVLLQKGDYGFYLSYNKENFSLGEIDDPEDINLDTAIKAIE 731 Query: 700 RIKGYDGPIVECEKCGSEM--HLKMGRFGKYMACTNEECKNTRKILRNGEVAPPKEDPVP 757 K + + G ++ + G++G Y+ T K I ++ + E + Sbjct: 732 AKKANNIAEFNLTENGKKIKAIVLNGKYGYYVQVTRNRIKKNYPIPKDLDPNNLTEQQIL 791 Query: 758 LP-------ELPCEKSDAYFVLRDG 775 + K + + + Sbjct: 792 SIISVKKTYKKSAPKGGSKTIRKPS 816 >UniRef50_B2V7T0 DNA topoisomerase I n=5 Tax=Aquificales RepID=B2V7T0_SULSY Length = 683 Score = 495 bits (1273), Expect = e-138, Method: Composition-based stats. Identities = 214/581 (36%), Positives = 314/581 (54%), Gaps = 47/581 (8%) Query: 3 KALVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKD 62 K +VIVESP KAK I+ +LG D++VK++VGH +DLP + Sbjct: 4 KKIVIVESPKKAKEISHFLGKDFIVKATVGHFKDLPENE--------------------- 42 Query: 63 ERGALVNRMGVDPWHNWEAHYEVLP-GKEKVVSELKQLAEKADHIYLATDLDREGEAIAW 121 MGVD + +E + + +K++SE+K+LAEK+ + +ATD DREG AI + Sbjct: 43 --------MGVD-LNTYEPKFVIKSQNHKKILSEIKKLAEKS-EVIIATDPDREGYAIGF 92 Query: 122 HLREVIGGDDARYSRVVFNEITKNAIRQAFNKP---GELNIDRVNAQQARRFMDRVVGYM 178 + E + R F+EITK I++ + N NA RR DR+VGY Sbjct: 93 FMYEELKKKAKEVKRAEFHEITKEHIKEKIKNAVPFEKTNFGLFNAFLGRRVGDRIVGYT 152 Query: 179 VSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSG-EALALQ 237 +SP+ ++I S GRVQS AVRL+VERE EI+ F P ++ + A S L Sbjct: 153 LSPIASREIGGRFSVGRVQSPAVRLIVEREIEIQNFKPTPYYVLSAVLRATSHVSPLTFT 212 Query: 238 VTHQNDKPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 ++N K NKE+ + + ++ + ++ + E K P PF TSTLQQ AST Sbjct: 213 AIYENPK---IENKEEAEKIYADIKDEKIATIKKVEKKQVKQSPKPPFTTSTLQQTASTV 269 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYLPESPNQYA 356 F +KTMM+AQ L+E+G ITY RTDS +S+ A++ +R I+ FGK YLPE Y Sbjct: 270 YRFAPEKTMMLAQDLFESGLITYHRTDSVRISEKAIDGIRNLINKEFGKDYLPEKIRVYK 329 Query: 357 SKENSQEAHEAIRPSDVNVMAES-----LKDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 SK +AHEAIR + + E K + D KL +LI+ + VA QM A ++ T Sbjct: 330 SKNTQADAHEAIRITHFVNLEEQKKLIKEKGLSEDHFKLLKLIYERTVASQMADAIFERT 389 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMP--ALRKGDEDRILPAVNKGDALTLVELTPAQH 469 + V + KA G IL+F G+ V +E++ LP + D LTL ++ + Sbjct: 390 SAAVDIKGYTFKASGSILKFKGYKAVYDLEEEEDKEENQKLPDLKNKDVLTLEKINLEEK 449 Query: 470 FTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDR 529 FTKPPAR++E LVK+LE+ GIGRPSTYA+II TI++RGYV EN + + + Sbjct: 450 FTKPPARYTEGGLVKKLEELGIGRPSTYATIIKTIKERGYVVKENGSLRPTENAFHLIEY 509 Query: 530 LEENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSD 570 L + +++Y FT +ME+ LD+V ++ +WK + Sbjct: 510 LNTRYNWVIDYSFTKKMEDFLDKVEENKKDWKEFVKQLHEK 550 >UniRef50_B2RGV8 DNA topoisomerase I n=47 Tax=Bacteroidetes RepID=B2RGV8_PORG3 Length = 709 Score = 494 bits (1272), Expect = e-138, Method: Composition-based stats. Identities = 147/705 (20%), Positives = 262/705 (37%), Gaps = 91/705 (12%) Query: 4 ALVIVESPAKAKTINKYL-----------GSDYVVKSSVGHIRDLPTSGSAAKKSADSTS 52 ++I E P+ A+ I + + G Y V ++GH+ K + Sbjct: 2 KVIIAEKPSVAREIARVVRATNKKNGYIEGGGYAVTWALGHLITAAMPEVYGIKGFHKEN 61 Query: 53 TKTAKKPKKDERGALVNRMGVDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDL 112 + + G Y+ P + +++L + A+ I +ATD Sbjct: 62 LPILPPVFTLIPRQVRSGKG----------YKADPSAVAQLKVIEKLFKAAEGIIVATDA 111 Query: 113 DREGEAIAWHLREVIGGDDARYSRVVFNEITKNAIRQAFNKP--GELNIDRVNAQQARRF 170 REGE + + E +G + R+ + +T AI++ + G + A +AR Sbjct: 112 GREGELVFRFIYEYLGIA-KPFERLWISSLTDKAIKEGLARLQNGAAYDNLYYAARARSE 170 Query: 171 MDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTP 229 D +VG + + RG S GRVQ+ + +V R E K F P+ FW++ + Sbjct: 171 ADWLVGINATQAISIAAGRGTYSLGRVQTPTLCMVCSRFLEHKKFEPQPFWQLSLAVKEG 230 Query: 230 SGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKAR-YSVLEREDKPTTSKPGAPFITST 288 R +K + A L++A +V K +P + +T Sbjct: 231 DESFRFSSAD-------RWFDKTEATALYDKLKQAPYATVETIVRKEARQEPPLLYDLTT 283 Query: 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVNMVRGYISDNFGKKYL 348 LQ+ A++R G+ ++T+ +AQRLYE YITY RT S + +D + I+ Sbjct: 284 LQKEANSRFGYSAEQTLSLAQRLYEKAYITYPRTGSRYVPEDVFAEIPAMIAFLHDHPVW 343 Query: 349 PESPNQ------YASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQ 402 + ++ H A+ + + D+ D +Y +I + + Sbjct: 344 GVHARRLTELNAHSVDGKKVTDHHALLITGKKPI-----DVFGDEAVIYDMIAGRMLEAF 398 Query: 403 MTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDR-------------- 448 D +T+T + + +G I++ +GW ++ RK D+++ Sbjct: 399 SARCVKDISTVTAVCEEVKFILKGEIIKEEGWRSILKNSRKKDKEQAEAEERESRENGEG 458 Query: 449 -ILPAVNKGDALTLVELTPAQHFTKPPARFSEASLVKELEKR----------------GI 491 I+P +G L L + AQ TKP +E+SL+ +E GI Sbjct: 459 IIIPQWEEGGQLPLCACSLAQGTTKPKPLHTESSLLAAMETAGKELEDEELRAQFKDCGI 518 Query: 492 GRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTAQMENSLD 551 G P+T A+II T+ R Y+ + + + G V + E ++ N + T Q E L Sbjct: 519 GTPATRAAIIETLFAREYMVRQKKSLVPTEKGLAVYSIVREM--KIGNAEMTGQWEADLA 576 Query: 552 QVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQMVLTSIDCPTCGRKMGIRTA 611 ++ E + + S TQ D+ + I CP CG+ + Sbjct: 577 KIERGELKERDFRKGIESYATQITDELLSSKI-----LFPKKQSDIHCPKCGKGTLVF-- 629 Query: 612 STGVFLGCSGYALPPKERCKTTINLVPENEVLNVLEGEDAETNAL 656 CS C T+ + L + N Sbjct: 630 -YPRCAKCS------DPNCGLTLFRSVAGKNLTDEQLTQLAVNGE 667 >UniRef50_A7I6L6 DNA topoisomerase n=5 Tax=Methanomicrobiales RepID=A7I6L6_METB6 Length = 942 Score = 494 bits (1272), Expect = e-138, Method: Composition-based stats. Identities = 164/704 (23%), Positives = 278/704 (39%), Gaps = 57/704 (8%) Query: 5 LVIVESPAKAKTINKYLGSDYVVKSSVGHIRDLPTSGSAAKKSADSTSTKTAKKPKKDER 64 L++ E A I + L V S T + D Sbjct: 3 LIVAEKNISAHRIAQILAGGTRVIEKK------DAGVSTYSFGDTITVGLRGHVVEVDFE 56 Query: 65 GALVNRMG--VDPWHNWEAHYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122 N P +A +P ++++VS +++LA AD + +ATD D EGE I Sbjct: 57 PGYENWRSEKYTPRSLIDAKTIKVPTEKRIVSLVQKLARHADRVTIATDFDTEGELIGKE 116 Query: 123 LREVIGGDDARYS--RVVFNEITKNAIRQAFNKPGELNIDRVNAQQARRFMDRVVGYMVS 180 E++ + R F+ IT I AF +L+ A +AR+ +D + G ++ Sbjct: 117 AYELVRAVNKNVKIDRARFSAITAQEIGSAFANTTDLDFALAAAGEARQSIDLMWGASLT 176 Query: 181 PLLWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEVDASTTTPSGEALAL 236 + RG LS GRVQS + ++V+RE+EI+ FVPE++W++ T + Sbjct: 177 RFISLAAKRGGNNILSVGRVQSPTLSMIVDREKEIEKFVPEKYWQLGLLTEKAG---EQI 233 Query: 237 QVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTR 296 + H N R +++ + A ++ V E + + +PF T+T AA+ Sbjct: 234 EARHTNG---RFKDQKAAELARDRTKE-PLVVTEVREGTKQDRSPSPFDTTTYIVAAAR- 288 Query: 297 LGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDA-----VNMVRGYISDNFGKKYLPES 351 LGF M +A+ LY GYI+Y RTD+T + +R + Sbjct: 289 LGFSAANAMRIAEELYMNGYISYPRTDNTVYPASLDLNGVLATIRNSPFTKDVDWIISHR 348 Query: 352 PNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDST 411 + + S H I P+ V + + DA ++Y+L+ R+F+A A + + Sbjct: 349 RAEPTRGKKSSTDHPPIYPTGVATR----EGIGDDAFRIYELVLRRFLATLAPDALWKTL 404 Query: 412 TLTVGAGDFRLKARGRILRFDGWTKVMPALRKGDEDRILPAVNKGDALTLVELTPAQHFT 471 + AG G +L GW V P + ILPA G+ L + ++ + T Sbjct: 405 KVNFEAGGETYTVTGGLLLEPGWHAVYPFSEAK--ETILPAFVTGEKLPIRKVNLEEKET 462 Query: 472 KPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531 PPAR++++ L++ +E+ G+G ST +I+ + R Y+ +G +VT+ LE Sbjct: 463 LPPARYTQSKLIQRMEELGLGTKSTRHEVIARLVSRKYIE--GNPLRPTLVGRVVTEALE 520 Query: 532 ENFRELMNYDFTAQMENSLDQVANHEAEWKAVLDHFFSDFTQQLDKAEKDPEEGGMRPNQ 591 +N + + T +E+ + Q+ + V+ S + D+ E + + G Sbjct: 521 QNADTITKPEMTQTIESHMQQIKESKRTRDDVIAESRSMLHKAFDQLEANEQVIGNDIRD 580 Query: 592 MVLTS---IDCPTCGRKMGIRTAS-TGVFLGCSGYALPPKERCKTTINLVPENEVLNVLE 647 CP CG + I+ + F+GCS Y C I L V Sbjct: 581 RTAEELNLGRCPACGGTLAIKHMRGSTQFIGCSRYP-----ECTFNIGLPVTQWGWAV-- 633 Query: 648 GEDAETNALRAKRRCPKCGTAMDSYLIDPKRKLHVCGNNPTCDG 691 R C K + R + P C Sbjct: 634 ---------RTDDICDKHHLHFVRLVRKGARPWDI--GCPLCHH 666 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.310 0.130 0.369 Lambda K H 0.267 0.0400 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 4,792,976,800 Number of Sequences: 3077464 Number of extensions: 195768434 Number of successful extensions: 711765 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 1535 Number of HSP's successfully gapped in prelim test: 674 Number of HSP's that attempted gapping in prelim test: 689277 Number of HSP's gapped (non-prelim): 7261 length of query: 865 length of database: 1,040,396,356 effective HSP length: 138 effective length of query: 727 effective length of database: 615,706,324 effective search space: 447618497548 effective search space used: 447618497548 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 98 (42.4 bits)