Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	H	R	P	R	W	T	L	S	Q	V	T	E	L	F	E	K	P	L	L	D	L	L	F	E	A	Q	Q	V	H	R	Q	H	F	D	P	R	Q	V	Q	V	S	T	L	L	S	I	K	T	G	A	C	P	E	D	C	K	Y	C
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	Q	S	S	R	Y	K	T	G	L	E	A	E	R	L	M	E	V	E	Q	V	L	E	S	A	R	K	A	K	A	A	G	S	T	R	F	C	M	G	A	A	W	K	N	P	H	E	R	D	M	P	Y	L	E	Q	M	V	Q	G	V
Secondary structure
SS confidence
Disorder			?		?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		K	A	M	G	L	E	A	C	M	T	L	G	T	L	S	E	S	Q	A	Q	R	L	A	N	A	G	L	D	Y	Y	N	H	N	L	D	T	S	P	E	F	Y	G	N	I	I	T	T	R	T	Y	Q	E	R	L	D	T	L	E	K	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	D	A	G	I	K	V	C	S	G	G	I	V	G	L	G	E	T	V	K	D	R	A	G	L	L	L	Q	L	A	N	L	P	T	P	P	E	S	V	P	I	N	M	L	V	K	V	K	G	T	P	L	A	D	N	D	D	V	D	A
Secondary structure
SS confidence
Disorder																																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	D	F	I	R	T	I	A	V	A	R	I	M	M	P	T	S	Y	V	R	L	S	A	G	R	E	Q	M	N	E	Q	T	Q	A	M	C	F	M	A	G	A	N	S	I	F	Y	G	C	K	L	L	T	T	P	N	P	E	E	D	K
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?																?	?	?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.
Sequence		D	L	Q	L	F	R	K	L	G	L	N	P	Q	Q	T	A	V	L	A	G	D	N	E	Q	Q	Q	R	L	E	Q	A	L	M	T	P	D	T	D	E	Y	Y	N	A	A	A	L
Secondary structure
SS confidence
Disorder																?	?	?	?	?	?	?	?	?	?	?	?	?					?		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1r30 chain A Region: 4 - 315 Aligned: 312 Modelled: 312 Confidence: 100.0% Identity: 100% Fold: TIM beta/alpha-barrel Superfamily: Radical SAM enzymes Family: Biotin synthase Phyre2 PDB 1r30 chain A Region: 4 - 315 Aligned: 312 Modelled: 312 Confidence: 100.0% Identity: 100% PDB header:transferase Chain: A: PDB Molecule:biotin synthase; PDBTitle: the crystal structure of biotin synthase, an s-2 adenosylmethionine-dependent radical enzyme Phyre2 PDB 3cix chain A Region: 5 - 321 Aligned: 307 Modelled: 312 Confidence: 100.0% Identity: 21% PDB header:adomet binding protein Chain: A: PDB Molecule:fefe-hydrogenase maturase; PDBTitle: x-ray structure of the [fefe]-hydrogenase maturase hyde from2 thermotoga maritima in complex with thiocyanate Phyre2 PDB 3t7v chain A Region: 6 - 316 Aligned: 303 Modelled: 311 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:methylornithine synthase pylb; PDBTitle: crystal structure of methylornithine synthase (pylb) Phyre2 PDB 1olt chain A Region: 46 - 254 Aligned: 204 Modelled: 206 Confidence: 99.9% Identity: 12% Fold: TIM beta/alpha-barrel Superfamily: Radical SAM enzymes Family: Oxygen-independent coproporphyrinogen III oxidase HemN Phyre2 PDB 2qgq chain F Region: 57 - 252 Aligned: 190 Modelled: 196 Confidence: 99.9% Identity: 15% PDB header:structural genomics, unknown function Chain: F: PDB Molecule:protein tm_1862; PDBTitle: crystal structure of tm_1862 from thermotoga maritima.2 northeast structural genomics consortium target vr77 Phyre2 PDB 1tv8 chain A Region: 46 - 248 Aligned: 199 Modelled: 203 Confidence: 99.8% Identity: 18% Fold: TIM beta/alpha-barrel Superfamily: Radical SAM enzymes Family: MoCo biosynthesis proteins Phyre2 PDB 3rfa chain A Region: 36 - 248 Aligned: 200 Modelled: 212 Confidence: 99.7% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:ribosomal rna large subunit methyltransferase n; PDBTitle: x-ray structure of rlmn from escherichia coli in complex with s-2 adenosylmethionine Phyre2 PDB 3c8f chain A Region: 48 - 251 Aligned: 197 Modelled: 203 Confidence: 99.4% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:pyruvate formate-lyase 1-activating enzyme; PDBTitle: 4fe-4s-pyruvate formate-lyase activating enzyme with2 partially disordered adomet Phyre2 PDB 2yx0 chain A Region: 32 - 247 Aligned: 207 Modelled: 216 Confidence: 99.4% Identity: 14% PDB header:metal binding protein Chain: A: PDB Molecule:radical sam enzyme; PDBTitle: crystal structure of p. horikoshii tyw1 Phyre2 PDB 2a5h chain C Region: 43 - 260 Aligned: 199 Modelled: 209 Confidence: 99.2% Identity: 17% PDB header:isomerase Chain: C: PDB Molecule:l-lysine 2,3-aminomutase; PDBTitle: 2.1 angstrom x-ray crystal structure of lysine-2,3-aminomutase from2 clostridium subterminale sb4, with michaelis analog (l-alpha-lysine3 external aldimine form of pyridoxal-5'-phosphate). Phyre2 PDB 1ka9 chain F Region: 69 - 313 Aligned: 227 Modelled: 244 Confidence: 99.1% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Histidine biosynthesis enzymes Phyre2 PDB 1thf chain D Region: 74 - 313 Aligned: 222 Modelled: 238 Confidence: 99.0% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Histidine biosynthesis enzymes Phyre2 PDB 1h5y chain A Region: 80 - 313 Aligned: 216 Modelled: 234 Confidence: 98.4% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: Histidine biosynthesis enzymes Phyre2 PDB 3can chain A Region: 99 - 251 Aligned: 143 Modelled: 153 Confidence: 98.4% Identity: 13% PDB header:lyase activator Chain: A: PDB Molecule:pyruvate-formate lyase-activating enzyme; PDBTitle: crystal structure of a domain of pyruvate-formate lyase-activating2 enzyme from bacteroides vulgatus atcc 8482 Phyre2 PDB 2ftp chain A Region: 76 - 313 Aligned: 225 Modelled: 224 Confidence: 98.3% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:hydroxymethylglutaryl-coa lyase; PDBTitle: crystal structure of hydroxymethylglutaryl-coa lyase from pseudomonas2 aeruginosa Phyre2 PDB 2cw6 chain B Region: 76 - 312 Aligned: 224 Modelled: 223 Confidence: 98.3% Identity: 12% PDB header:lyase Chain: B: PDB Molecule:hydroxymethylglutaryl-coa lyase, mitochondrial; PDBTitle: crystal structure of human hmg-coa lyase: insights into2 catalysis and the molecular basis for3 hydroxymethylglutaric aciduria Phyre2 PDB 1nvm chain G Region: 76 - 312 Aligned: 210 Modelled: 231 Confidence: 98.3% Identity: 12% PDB header:lyase/oxidoreductase Chain: G: PDB Molecule:4-hydroxy-2-oxovalerate aldolase; PDBTitle: crystal structure of a bifunctional aldolase-dehydrogenase :2 sequestering a reactive and volatile intermediate Phyre2 PDB 2z2u chain A Region: 53 - 228 Aligned: 159 Modelled: 176 Confidence: 98.2% Identity: 15% PDB header:metal binding protein Chain: A: PDB Molecule:upf0026 protein mj0257; PDBTitle: crystal structure of archaeal tyw1 Phyre2 PDB 1nvm chain A domain 2 Region: 75 - 312 Aligned: 214 Modelled: 232 Confidence: 98.1% Identity: 12% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: HMGL-like Phyre2 1 d1r30a_ 2 c1r30A_ 3 c3cixA_ 4 c3t7vA_ 5 d1olta_ 6 c2qgqF_ 7 d1tv8a_ 8 c3rfaA_ 9 c3c8fA_ 10 c2yx0A_ 11 c2a5hC_ 12 d1ka9f_ 13 d1thfd_ 14 d1h5ya_ 15 c3canA_ 16 c2ftpA_ 17 c2cw6B_ 18 c1nvmG_ 19 c2z2uA_ 20 d1nvma2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499