Phyre 2 Results for P39285

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Email | l.a.kelley@imperial.ac.uk
Description | P39285
Date | Thu Jan 5 11:58:57 GMT 2012
Unique Job ID | 0106ad3fe443e7d2

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template c2vv5D_
Top template information
PDB header:membrane protein Chain: D: PDB Molecule:small-conductance mechanosensitive channel; PDBTitle: the open structure of mscs
Confidence and coverage
Confidence: | 100.0% | Coverage: | 23%
251 residues ( 23% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
775 residues ( 70%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | R | L | I | I | T | F | L | M | A | W | C | L | S | W | G | A | Y | A | A | T | A | P | D | S | K | Q | I | T | Q | E | L | E | Q | A | K | A | A | K | P | A | Q | P | E | V | V | E | A | L | Q | S | A | L | N | A | L | E | E | R | K
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | G | S | L | E | R | I | K | Q | Y | Q | Q | V | I | D | N | Y | P | K | L | S | A | T | L | R | A | Q | L | N | N | M | R | D | E | P | R | S | V | S | P | G | M | S | T | D | A | L | N | Q | E | I | L | Q | V | S | S | Q | L | L | D | K
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | S | R | Q | A | Q | Q | E | Q | E | R | A | R | E | I | A | D | S | L | N | Q | L | P | Q | Q | Q | T | D | A | R | R | Q | L | N | E | I | E | R | R | L | G | T | L | T | G | N | T | P | L | N | Q | A | Q | N | F | A | L | Q | S | D | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | A | R | L | K | A | L | V | D | E | L | E | L | A | Q | L | S | A | N | N | R | Q | E | L | A | R | L | R | S | E | L | A | E | K | E | S | Q | Q | L | D | A | Y | L | Q | A | L | R | N | Q | L | N | S | Q | R | Q | L | E | A | E | R | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300
Sequence |  | L | E | S | T | E | L | L | A | E | N | S | A | D | L | P | K | D | I | V | A | Q | F | K | I | N | R | E | L | S | A | A | L | N | Q | Q | A | Q | R | M | D | L | V | A | S | Q | Q | R | Q | A | A | S | Q | T | L | Q | V | R | Q | A | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360
Sequence |  | N | T | L | R | E | Q | S | Q | W | L | G | S | S | N | L | L | G | E | A | L | R | A | Q | V | A | R | L | P | E | M | P | K | P | Q | Q | L | D | T | E | M | A | Q | L | R | V | Q | R | L | R | Y | E | D | L | L | N | K | Q | P | L | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420
Sequence |  | R | Q | I | H | Q | A | D | G | Q | P | L | T | A | E | Q | N | R | I | L | E | A | Q | L | R | T | Q | R | E | L | L | N | S | L | L | Q | G | G | D | T | L | L | L | E | L | T | K | L | K | V | S | N | G | Q | L | E | D | A | L | K | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480
Sequence |  | V | N | E | A | T | H | R | Y | L | F | W | T | S | D | V | R | P | M | T | I | A | W | P | L | E | I | A | Q | D | L | R | R | L | I | S | L | D | T | F | S | Q | L | G | K | A | S | V | M | M | L | T | S | K | E | T | I | L | P | L | F
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540
Sequence |  | G | A | L | I | L | V | G | C | S | I | Y | S | R | R | Y | F | T | R | F | L | E | R | S | A | A | K | V | G | K | V | T | Q | D | H | F | W | L | T | L | R | T | L | F | W | S | I | L | V | A | S | P | L | P | V | L | W | M | T | L | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  | ? |  |  | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . | . | . | 600
Sequence |  | Y | G | L | R | E | A | W | P | Y | P | L | A | V | A | I | G | D | G | V | T | A | T | V | P | L | L | W | V | V | M | I | C | A | T | F | A | R | P | N | G | L | F | I | A | H | F | G | W | P | R | E | R | V | S | R | G | M | R | Y | Y
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  | ? |  |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  | ? | ? | ? |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 610 | . | . | . | . | . | . | . | . | . | 620 | . | . | . | . | . | . | . | . | . | 630 | . | . | . | . | . | . | . | . | . | 640 | . | . | . | . | . | . | . | . | . | 650 | . | . | . | . | . | . | . | . | . | 660
Sequence |  | L | M | S | I | G | L | I | V | P | L | I | M | A | L | M | M | F | D | N | L | D | D | R | E | F | S | G | S | L | G | R | L | C | F | I | L | I | C | G | A | L | A | V | V | T | L | S | L | K | K | A | G | I | P | L | Y | L | N | K | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 670 | . | . | . | . | . | . | . | . | . | 680 | . | . | . | . | . | . | . | . | . | 690 | . | . | . | . | . | . | . | . | . | 700 | . | . | . | . | . | . | . | . | . | 710 | . | . | . | . | . | . | . | . | . | 720
Sequence |  | G | S | G | D | N | I | T | N | H | M | L | W | N | M | M | I | G | A | P | L | V | A | I | L | A | S | A | V | G | Y | L | A | T | A | Q | A | L | L | A | R | L | E | T | S | V | A | I | W | F | L | L | L | V | V | Y | H | V | I | R | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 730 | . | . | . | . | . | . | . | . | . | 740 | . | . | . | . | . | . | . | . | . | 750 | . | . | . | . | . | . | . | . | . | 760 | . | . | . | . | . | . | . | . | . | 770 | . | . | . | . | . | . | . | . | . | 780
Sequence |  | W | M | L | I | Q | R | R | R | L | A | F | D | R | A | K | H | R | R | A | E | M | L | A | Q | R | A | R | G | E | E | E | A | H | H | H | S | S | P | E | G | A | I | E | V | D | E | S | E | V | D | L | D | A | I | S | A | Q | S | L | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 790 | . | . | . | . | . | . | . | . | . | 800 | . | . | . | . | . | . | . | . | . | 810 | . | . | . | . | . | . | . | . | . | 820 | . | . | . | . | . | . | . | . | . | 830 | . | . | . | . | . | . | . | . | . | 840
Sequence |  | L | V | R | S | I | L | M | L | I | A | L | L | S | V | I | V | L | W | S | E | I | H | S | A | F | G | F | L | E | N | I | S | L | W | D | V | T | S | T | V | Q | G | V | E | S | L | E | P | I | T | L | G | A | V | L | I | A | I | L | V
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? |  | ? | ? |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 850 | . | . | . | . | . | . | . | . | . | 860 | . | . | . | . | . | . | . | . | . | 870 | . | . | . | . | . | . | . | . | . | 880 | . | . | . | . | . | . | . | . | . | 890 | . | . | . | . | . | . | . | . | . | 900
Sequence |  | F | I | I | T | T | Q | L | V | R | N | L | P | A | L | L | E | L | A | I | L | Q | H | L | D | L | T | P | G | T | G | Y | A | I | T | T | I | T | K | Y | L | L | M | L | I | G | G | L | V | G | F | S | M | I | G | I | E | W | S | K | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 910 | . | . | . | . | . | . | . | . | . | 920 | . | . | . | . | . | . | . | . | . | 930 | . | . | . | . | . | . | . | . | . | 940 | . | . | . | . | . | . | . | . | . | 950 | . | . | . | . | . | . | . | . | . | 960
Sequence |  | Q | W | L | V | A | A | L | G | V | G | L | G | F | G | L | Q | E | I | F | A | N | F | I | S | G | L | I | I | L | F | E | K | P | I | R | I | G | D | T | V | T | I | R | D | L | T | G | S | V | T | K | I | N | T | R | A | T | T | I | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 970 | . | . | . | . | . | . | . | . | . | 980 | . | . | . | . | . | . | . | . | . | 990 | . | . | . | . | . | . | . | . | . | 1000 | . | . | . | . | . | . | . | . | . | 1010 | . | . | . | . | . | . | . | . | . | 1020
Sequence |  | D | W | D | R | K | E | I | I | V | P | N | K | A | F | I | T | E | Q | F | I | N | W | S | L | S | D | S | V | T | R | V | V | L | T | I | P | A | P | A | D | A | N | S | E | E | V | T | E | I | L | L | T | A | A | R | R | C | S | L | V
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1030 | . | . | . | . | . | . | . | . | . | 1040 | . | . | . | . | . | . | . | . | . | 1050 | . | . | . | . | . | . | . | . | . | 1060 | . | . | . | . | . | . | . | . | . | 1070 | . | . | . | . | . | . | . | . | . | 1080
Sequence |  | I | D | N | P | A | P | E | V | F | L | V | D | L | Q | Q | G | I | Q | I | F | E | L | R | I | Y | A | A | E | M | G | H | R | M | P | L | R | H | E | I | H | Q | L | I | L | A | G | F | H | A | H | G | I | D | M | P | F | P | P | F | Q
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1090 | . | . | . | . | . | . | . | . | . | 1100 | . | . | . | . | . | . | .
Sequence |  | M | R | L | E | S | L | N | G | K | Q | T | G | R | T | L | T | S | A | G | K | G | R | Q | A | G | S | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c2vv5D_ |

### PDB 2vv5 chain D

Region: 833 - 1086
Aligned: 251
Modelled: 254
Confidence: 100.0%
Identity: 20%
PDB header:membrane protein
Chain: D: PDB Molecule:small-conductance mechanosensitive channel;
PDBTitle: the open structure of mscs

Phyre2
2 |
| d2vv5a2 |

### PDB 2vv5 chain A domain 2

Region: 985 - 1086
Aligned: 101
Modelled: 102
Confidence: 99.6%
Identity: 20%
Fold: Ferredoxin-like
Superfamily: Mechanosensitive channel protein MscS (YggB), C-terminal domain
Family: Mechanosensitive channel protein MscS (YggB), C-terminal domain

Phyre2
3 |
| d2vv5a1 |

### PDB 2vv5 chain A domain 1

Region: 918 - 983
Aligned: 66
Modelled: 66
Confidence: 99.2%
Identity: 29%
Fold: Sm-like fold
Superfamily: Sm-like ribonucleoproteins
Family: Mechanosensitive channel protein MscS (YggB), middle domain

Phyre2
4 |
| d2vv5a3 |

### PDB 2vv5 chain A domain 3

Region: 833 - 916
Aligned: 83
Modelled: 84
Confidence: 98.7%
Identity: 12%
Fold: Mechanosensitive channel protein MscS (YggB), transmembrane region
Superfamily: Mechanosensitive channel protein MscS (YggB), transmembrane region
Family: Mechanosensitive channel protein MscS (YggB), transmembrane region

Phyre2
5 |
| c1ciiA_ |

### PDB 1cii chain A

Region: 19 - 576
Aligned: 515
Modelled: 521
Confidence: 98.7%
Identity: 12%
PDB header:transmembrane protein
Chain: A: PDB Molecule:colicin ia;
PDBTitle: colicin ia

Phyre2
6 |
| c1c1gA_ |

### PDB 1c1g chain A

Region: 26 - 310
Aligned: 282
Modelled: 285
Confidence: 98.5%
Identity: 12%
PDB header:contractile protein
Chain: A: PDB Molecule:tropomyosin;
PDBTitle: crystal structure of tropomyosin at 7 angstroms resolution2 in the spermine-induced crystal form

Phyre2
7 |
| c1yvlB_ |

### PDB 1yvl chain B

Region: 48 - 317
Aligned: 266
Modelled: 270
Confidence: 98.1%
Identity: 9%
PDB header:signaling protein
Chain: B: PDB Molecule:signal transducer and activator of transcription
PDBTitle: structure of unphosphorylated stat1

Phyre2
8 |
| c1sjjB_ |

### PDB 1sjj chain B

Region: 24 - 423
Aligned: 400
Modelled: 400
Confidence: 97.9%
Identity: 10%
PDB header:contractile protein
Chain: B: PDB Molecule:actinin;
PDBTitle: cryo-em structure of chicken gizzard smooth muscle alpha-2 actinin

Phyre2
9 |
| c2oevA_ |

### PDB 2oev chain A

Region: 15 - 310
Aligned: 294
Modelled: 296
Confidence: 97.7%
Identity: 9%
PDB header:protein transport
Chain: A: PDB Molecule:programmed cell death 6-interacting protein;
PDBTitle: crystal structure of alix/aip1

Phyre2
10 |
| c1bf5A_ |

### PDB 1bf5 chain A

Region: 64 - 224
Aligned: 160
Modelled: 161
Confidence: 97.7%
Identity: 9%
PDB header:gene regulation/dna
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: tyrosine phosphorylated stat-1/dna complex

Phyre2
11 |
| c3ojaB_ |

### PDB 3oja chain B

Region: 23 - 165
Aligned: 143
Modelled: 143
Confidence: 97.5%
Identity: 12%
PDB header:protein binding
Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein
PDBTitle: crystal structure of lrim1/apl1c complex

Phyre2
12 |
| c2oexB_ |

### PDB 2oex chain B

Region: 13 - 310
Aligned: 296
Modelled: 298
Confidence: 97.3%
Identity: 8%
PDB header:protein transport
Chain: B: PDB Molecule:programmed cell death 6-interacting protein;
PDBTitle: structure of alix/aip1 v domain

Phyre2
13 |
| c1bg1A_ |

### PDB 1bg1 chain A

Region: 129 - 311
Aligned: 172
Modelled: 183
Confidence: 97.2%
Identity: 10%
PDB header:transcription/dna
Chain: A: PDB Molecule:protein (transcription factor stat3b);
PDBTitle: transcription factor stat3b/dna complex

Phyre2
14 |
| c2efrB_ |

### PDB 2efr chain B

Region: 73 - 226
Aligned: 152
Modelled: 154
Confidence: 97.0%
Identity: 7%
PDB header:contractile protein
Chain: B: PDB Molecule:general control protein gcn4 and tropomyosin 1 alpha chain;
PDBTitle: crystal structure of the c-terminal tropomyosin fragment with n- and2 c-terminal extensions of the leucine zipper at 1.8 angstroms3 resolution

Phyre2
15 |
| c3na7A_ |

### PDB 3na7 chain A

Region: 24 - 182
Aligned: 159
Modelled: 159
Confidence: 96.9%
Identity: 10%
PDB header:gene regulation, chaperone
Chain: A: PDB Molecule:hp0958;
PDBTitle: 2.2 angstrom structure of the hp0958 protein from helicobacter pylori2 ccug 17874

Phyre2
16 |
| c3cwgA_ |

### PDB 3cwg chain A

Region: 64 - 224
Aligned: 161
Modelled: 161
Confidence: 96.9%
Identity: 10%
PDB header:transcription
Chain: A: PDB Molecule:signal transducer and activator of transcription
PDBTitle: unphosphorylated mouse stat3 core fragment

Phyre2
17 |
| c3dtpA_ |

### PDB 3dtp chain A

Region: 112 - 229
Aligned: 118
Modelled: 118
Confidence: 96.5%
Identity: 12%
PDB header:contractile protein
Chain: A: PDB Molecule:myosin 2 heavy chain chimera of smooth and
PDBTitle: tarantula heavy meromyosin obtained by flexible docking to2 tarantula muscle thick filament cryo-em 3d-map

Phyre2
18 |
| c1f5nA_ |

### PDB 1f5n chain A

Region: 46 - 307
Aligned: 262
Modelled: 262
Confidence: 96.4%
Identity: 8%
PDB header:signaling protein
Chain: A: PDB Molecule:interferon-induced guanylate-binding protein 1;
PDBTitle: human guanylate binding protein-1 in complex with the gtp2 analogue, gmppnp.

Phyre2
19 |
| c1ei3C_ |

### PDB 1ei3 chain C

Region: 61 - 171
Aligned: 110
Modelled: 111
Confidence: 96.4%
Identity: 8%
PDB header:
PDB COMPND:

Phyre2
20 |
| c1g8xB_ |

### PDB 1g8x chain B

Region: 25 - 227
Aligned: 203
Modelled: 203
Confidence: 96.4%
Identity: 9%
PDB header:structural protein
Chain: B: PDB Molecule:myosin ii heavy chain fused to alpha-actinin 3;
PDBTitle: structure of a genetically engineered molecular motor

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c2vv5D_ |
|  | 100.0 | 20 | PDB header:membrane protein Chain: D: PDB Molecule:small-conductance mechanosensitive channel; PDBTitle: the open structure of mscs
2 | d2vv5a2 |
|  | 99.6 | 20 | Fold:Ferredoxin-like Superfamily:Mechanosensitive channel protein MscS (YggB), C-terminal domain Family:Mechanosensitive channel protein MscS (YggB), C-terminal domain
3 | d2vv5a1 |
|  | 99.2 | 29 | Fold:Sm-like fold Superfamily:Sm-like ribonucleoproteins Family:Mechanosensitive channel protein MscS (YggB), middle domain
4 | d2vv5a3 |
|  | 98.7 | 12 | Fold:Mechanosensitive channel protein MscS (YggB), transmembrane region Superfamily:Mechanosensitive channel protein MscS (YggB), transmembrane region Family:Mechanosensitive channel protein MscS (YggB), transmembrane region
5 | c1ciiA_ |
|  | 98.7 | 12 | PDB header:transmembrane protein Chain: A: PDB Molecule:colicin ia; PDBTitle: colicin ia
6 | c1c1gA_ |
|  | 98.5 | 12 | PDB header:contractile protein Chain: A: PDB Molecule:tropomyosin; PDBTitle: crystal structure of tropomyosin at 7 angstroms resolution2 in the spermine-induced crystal form
7 | c1yvlB_ |
|  | 98.1 | 9 | PDB header:signaling protein Chain: B: PDB Molecule:signal transducer and activator of transcription PDBTitle: structure of unphosphorylated stat1
8 | c1sjjB_ |
|  | 97.9 | 10 | PDB header:contractile protein Chain: B: PDB Molecule:actinin; PDBTitle: cryo-em structure of chicken gizzard smooth muscle alpha-2 actinin
9 | c2oevA_ |
|  | 97.7 | 9 | PDB header:protein transport Chain: A: PDB Molecule:programmed cell death 6-interacting protein; PDBTitle: crystal structure of alix/aip1
10 | c1bf5A_ |
|  | 97.7 | 9 | PDB header:gene regulation/dna Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: tyrosine phosphorylated stat-1/dna complex
11 | c3ojaB_ |
|  | 97.5 | 12 | PDB header:protein binding Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein PDBTitle: crystal structure of lrim1/apl1c complex
12 | c2oexB_ |
|  | 97.3 | 8 | PDB header:protein transport Chain: B: PDB Molecule:programmed cell death 6-interacting protein; PDBTitle: structure of alix/aip1 v domain
13 | c1bg1A_ |
|  | 97.2 | 10 | PDB header:transcription/dna Chain: A: PDB Molecule:protein (transcription factor stat3b); PDBTitle: transcription factor stat3b/dna complex
14 | c2efrB_ |
|  | 97.0 | 7 | PDB header:contractile protein Chain: B: PDB Molecule:general control protein gcn4 and tropomyosin 1 alpha chain; PDBTitle: crystal structure of the c-terminal tropomyosin fragment with n- and2 c-terminal extensions of the leucine zipper at 1.8 angstroms3 resolution
15 | c3na7A_ |
|  | 96.9 | 10 | PDB header:gene regulation, chaperone Chain: A: PDB Molecule:hp0958; PDBTitle: 2.2 angstrom structure of the hp0958 protein from helicobacter pylori2 ccug 17874
16 | c3cwgA_ |
|  | 96.9 | 10 | PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment
17 | c3dtpA_ |
|  | 96.5 | 12 | PDB header:contractile protein Chain: A: PDB Molecule:myosin 2 heavy chain chimera of smooth and PDBTitle: tarantula heavy meromyosin obtained by flexible docking to2 tarantula muscle thick filament cryo-em 3d-map
18 | c1f5nA_ |
|  | 96.4 | 8 | PDB header:signaling protein Chain: A: PDB Molecule:interferon-induced guanylate-binding protein 1; PDBTitle: human guanylate binding protein-1 in complex with the gtp2 analogue, gmppnp.
19 | c1ei3C_ |
|  | 96.4 | 8 | PDB header: PDB COMPND:
20 | c1g8xB_ |
|  | 96.4 | 9 | PDB header:structural protein Chain: B: PDB Molecule:myosin ii heavy chain fused to alpha-actinin 3; PDBTitle: structure of a genetically engineered molecular motor
21 | c3ghgK_ |
| not modelled | 96.1 | 9 | PDB header:blood clotting Chain: K: PDB Molecule:fibrinogen beta chain; PDBTitle: crystal structure of human fibrinogen
22 | c3hizB_ |
| not modelled | 95.9 | 10 | PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
23 | c2d3eD_ |
| not modelled | 95.6 | 9 | PDB header:contractile protein Chain: D: PDB Molecule:general control protein gcn4 and tropomyosin 1 PDBTitle: crystal structure of the c-terminal fragment of rabbit2 skeletal alpha-tropomyosin
24 | c2v71A_ |
| not modelled | 95.6 | 9 | PDB header:nuclear protein Chain: A: PDB Molecule:nuclear distribution protein nude-like 1; PDBTitle: coiled-coil region of nudel
25 | c2ch7A_ |
| not modelled | 95.4 | 10 | PDB header:chemotaxis Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of the cytoplasmic domain of a bacterial2 chemoreceptor from thermotoga maritima
26 | c1jchC_ |
| not modelled | 95.3 | 4 | PDB header:ribosome inhibitor, hydrolase Chain: C: PDB Molecule:colicin e3; PDBTitle: crystal structure of colicin e3 in complex with its immunity protein
27 | c1ei3E_ |
| not modelled | 95.0 | 11 | PDB header: PDB COMPND:
28 | c3o0zD_ |
| not modelled | 94.9 | 14 | PDB header:transferase Chain: D: PDB Molecule:rho-associated protein kinase 1; PDBTitle: crystal structure of a coiled-coil domain from human rock i
29 | c2fxmB_ |
| not modelled | 94.8 | 13 | PDB header:contractile protein Chain: B: PDB Molecule:myosin heavy chain, cardiac muscle beta isoform; PDBTitle: structure of the human beta-myosin s2 fragment
30 | c3ojaA_ |
| not modelled | 94.7 | 11 | PDB header:protein binding Chain: A: PDB Molecule:leucine-rich immune molecule 1; PDBTitle: crystal structure of lrim1/apl1c complex
31 | c4a55B_ |
| not modelled | 94.7 | 8 | PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha; PDBTitle: crystal structure of p110alpha in complex with ish2 of p85alpha and2 the inhibitor pik-108
32 | c1y4cA_ |
| not modelled | 94.7 | 12 | PDB header:de novo protein Chain: A: PDB Molecule:maltose binding protein fused with designed PDBTitle: designed helical protein fusion mbp
33 | c1deqF_ |
| not modelled | 94.5 | 5 | PDB header: PDB COMPND:
34 | c2dfsA_ |
| not modelled | 94.1 | 10 | PDB header:contractile protein/transport protein Chain: A: PDB Molecule:myosin-5a; PDBTitle: 3-d structure of myosin-v inhibited state
35 | c2v1yB_ |
| not modelled | 94.0 | 7 | PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha; PDBTitle: structure of a phosphoinositide 3-kinase alpha adaptor-2 binding domain (abd) in a complex with the ish2 domain3 from p85 alpha
36 | c2y3aB_ |
| not modelled | 93.9 | 13 | PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
37 | c1deqO_ |
| not modelled | 93.8 | 9 | PDB header: PDB COMPND:
38 | c2b9cA_ |
| not modelled | 93.6 | 12 | PDB header:contractile protein Chain: A: PDB Molecule:striated-muscle alpha tropomyosin; PDBTitle: structure of tropomyosin's mid-region: bending and binding2 sites for actin
39 | c2j69D_ |
| not modelled | 92.1 | 10 | PDB header:hydrolase Chain: D: PDB Molecule:bacterial dynamin-like protein; PDBTitle: bacterial dynamin-like protein bdlp
40 | c3u59C_ |
| not modelled | 91.2 | 15 | PDB header:contractile protein Chain: C: PDB Molecule:tropomyosin beta chain; PDBTitle: n-terminal 98-aa fragment of smooth muscle tropomyosin beta
41 | c1hciB_ |
| not modelled | 91.1 | 11 | PDB header:triple-helix coiled coil Chain: B: PDB Molecule:alpha-actinin 2; PDBTitle: crystal structure of the rod domain of alpha-actinin
42 | c3ipkA_ |
| not modelled | 89.6 | 12 | PDB header:cell adhesion Chain: A: PDB Molecule:agi/ii; PDBTitle: crystal structure of a3vp1 of agi/ii of streptococcus mutans
43 | c1deqD_ |
| not modelled | 87.8 | 10 | PDB header: PDB COMPND:
44 | d2ap3a1 |
| not modelled | 87.4 | 11 | Fold:Four-helical up-and-down bundle Superfamily:MW0975(SA0943)-like Family:MW0975(SA0943)-like
45 | c3hnwB_ |
| not modelled | 84.8 | 20 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a basic coiled-coil protein of unknown function2 from eubacterium eligens atcc 27750
46 | c2zkrt_ |
| not modelled | 84.8 | 24 | PDB header:ribosomal protein/rna Chain: T: PDB Molecule:rna expansion segment es39 part iii; PDBTitle: structure of a mammalian ribosomal 60s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map
47 | c3ol1A_ |
| not modelled | 84.8 | 12 | PDB header:structural protein Chain: A: PDB Molecule:vimentin; PDBTitle: crystal structure of vimentin (fragment 144-251) from homo sapiens,2 northeast structural genomics consortium target hr4796b
48 | c2v66C_ |
| not modelled | 84.5 | 11 | PDB header:structural protein Chain: C: PDB Molecule:nuclear distribution protein nude-like 1; PDBTitle: crystal structure of the coiled-coil domain of ndel1 (a.a.2 58 to 169)c
49 | c3r6nA_ |
| not modelled | 84.1 | 5 | PDB header:cell adhesion Chain: A: PDB Molecule:desmoplakin; PDBTitle: crystal structure of a rigid four spectrin repeat fragment of the2 human desmoplakin plakin domain
50 | c2gl2B_ |
| not modelled | 83.5 | 10 | PDB header:cell adhesion Chain: B: PDB Molecule:adhesion a; PDBTitle: crystal structure of the tetra muntant (t66g,r67g,f68g,2 y69g) of bacterial adhesin fada
51 | c3g67A_ |
| not modelled | 83.3 | 7 | PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of a soluble chemoreceptor from thermotoga2 maritima
52 | c3l9oA_ |
| not modelled | 80.6 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent rna helicase dob1; PDBTitle: crystal structure of mtr4, a co-factor of the nuclear exosome
53 | d2hqha1 |
| not modelled | 80.5 | 33 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
54 | d2cqaa1 |
| not modelled | 79.8 | 32 | Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:TIP49 domain
55 | c2rd0B_ |
| not modelled | 77.6 | 10 | PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha; PDBTitle: structure of a human p110alpha/p85alpha complex
56 | c3edvB_ |
| not modelled | 76.3 | 10 | PDB header:structural protein Chain: B: PDB Molecule:spectrin beta chain, brain 1; PDBTitle: crystal structure of repeats 14-16 of beta2-spectrin
57 | c1l8dB_ |
| not modelled | 74.4 | 7 | PDB header:replication Chain: B: PDB Molecule:dna double-strand break repair rad50 atpase; PDBTitle: rad50 coiled-coil zn hook
58 | c2zv4O_ |
| not modelled | 74.3 | 13 | PDB header:structural protein Chain: O: PDB Molecule:major vault protein; PDBTitle: the structure of rat liver vault at 3.5 angstrom resolution
59 | d2cp6a1 |
| not modelled | 74.2 | 30 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
60 | d1nz9a_ |
| not modelled | 74.0 | 35 | Fold:SH3-like barrel Superfamily:Translation proteins SH3-like domain Family:N-utilization substance G protein NusG, C-terminal domain
61 | c3kbtA_ |
| not modelled | 73.9 | 9 | PDB header:structural protein Chain: A: PDB Molecule:spectrin beta chain, erythrocyte; PDBTitle: crystal structure of the ankyrin binding domain of human erythroid2 beta spectrin (repeats 13-15) in complex with the spectrin binding3 domain of human erythroid ankyrin (zu5-ank)
62 | d1nppa2 |
| not modelled | 72.0 | 22 | Fold:SH3-like barrel Superfamily:Translation proteins SH3-like domain Family:N-utilization substance G protein NusG, C-terminal domain
63 | c2wpqA_ |
| not modelled | 71.6 | 9 | PDB header:membrane protein Chain: A: PDB Molecule:trimeric autotransporter adhesin fragment; PDBTitle: salmonella enterica sada 479-519 fused to gcn4 adaptors (2 sadak3, in-register fusion)
64 | c2kvqG_ |
| not modelled | 70.9 | 18 | PDB header:transcription Chain: G: PDB Molecule:transcription antitermination protein nusg; PDBTitle: solution structure of nuse:nusg-ctd complex
65 | c2jvvA_ |
| not modelled | 70.9 | 18 | PDB header:transcription Chain: A: PDB Molecule:transcription antitermination protein nusg; PDBTitle: solution structure of e. coli nusg carboxyterminal domain
66 | c4a1cS_ |
| not modelled | 70.5 | 40 | PDB header:ribosome Chain: S: PDB Molecule:rpl26; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna,3 5.8s rrna and proteins of molecule 4.
67 | d1vqot1 |
| not modelled | 68.6 | 15 | Fold:SH3-like barrel Superfamily:Translation proteins SH3-like domain Family:Ribosomal proteins L24p and L21e
68 | c3iz5Y_ |
| not modelled | 67.0 | 35 | PDB header:ribosome Chain: Y: PDB Molecule:60s ribosomal protein l26 (l24p); PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome
69 | c3lssA_ |
| not modelled | 66.5 | 13 | PDB header:ligase Chain: A: PDB Molecule:seryl-trna synthetase; PDBTitle: trypanosoma brucei seryl-trna synthetase in complex with atp
70 | c2e6zA_ |
| not modelled | 66.0 | 20 | PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt5; PDBTitle: solution structure of the second kow motif of human2 transcription elongation factor spt5
71 | d1whka_ |
| not modelled | 65.9 | 13 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
72 | d2plsa1 |
| not modelled | 65.2 | 17 | Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like
73 | c2vfyA_ |
| not modelled | 65.0 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:akap18 delta; PDBTitle: akap18 delta central domain
74 | d1whma_ |
| not modelled | 63.3 | 23 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
75 | d2coya1 |
| not modelled | 63.2 | 27 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
76 | c2i1jA_ |
| not modelled | 62.8 | 11 | PDB header:cell adhesion, membrane protein Chain: A: PDB Molecule:moesin; PDBTitle: moesin from spodoptera frugiperda at 2.1 angstroms resolution
77 | d2cp5a1 |
| not modelled | 62.5 | 20 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
78 | d1t9ha1 |
| not modelled | 61.5 | 33 | Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Cold shock DNA-binding domain-like
79 | d2coza1 |
| not modelled | 60.8 | 27 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
80 | c2e7sM_ |
| not modelled | 60.8 | 7 | PDB header:endocytosis/exocytosis Chain: M: PDB Molecule:rab guanine nucleotide exchange factor sec2; PDBTitle: crystal structure of the yeast sec2p gef domain
81 | c1i84V_ |
| not modelled | 60.6 | 18 | PDB header:contractile protein Chain: V: PDB Molecule:smooth muscle myosin heavy chain; PDBTitle: cryo-em structure of the heavy meromyosin subfragment of2 chicken gizzard smooth muscle myosin with regulatory light3 chain in the dephosphorylated state. only c alphas4 provided for regulatory light chain. only backbone atoms5 provided for s2 fragment.
82 | c1l2fA_ |
| not modelled | 60.6 | 19 | PDB header:transcription Chain: A: PDB Molecule:n utilization substance protein a; PDBTitle: crystal structure of nusa from thermotoga maritima: a2 structure-based role of the n-terminal domain
83 | d2cp2a1 |
| not modelled | 60.5 | 20 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
84 | c2qihA_ |
| not modelled | 60.5 | 15 | PDB header:cell adhesion Chain: A: PDB Molecule:protein uspa1; PDBTitle: crystal structure of 527-665 fragment of uspa1 protein from2 moraxella catarrhalis
85 | c3cnrA_ |
| not modelled | 59.6 | 23 | PDB header:unknown function Chain: A: PDB Molecule:type iv fimbriae assembly protein; PDBTitle: crystal structure of pilz (xac1133) from xanthomonas2 axonopodis pv citri
86 | d1yeza1 |
| not modelled | 59.5 | 21 | Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:TRAM domain
87 | c2jeeA_ |
| not modelled | 59.5 | 9 | PDB header:cell cycle Chain: A: PDB Molecule:yiiu; PDBTitle: xray structure of e. coli yiiu
88 | d1whja_ |
| not modelled | 59.4 | 24 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
89 | d2e3ha1 |
| not modelled | 59.4 | 30 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
90 | c2k52A_ |
| not modelled | 58.8 | 16 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein mj1198; PDBTitle: structure of uncharacterized protein mj1198 from2 methanocaldococcus jannaschii. northeast structural3 genomics target mjr117b
91 | d2do3a1 |
| not modelled | 57.1 | 28 | Fold:SH3-like barrel Superfamily:Translation proteins SH3-like domain Family:SPT5 KOW domain-like
92 | d2p13a1 |
| not modelled | 57.0 | 17 | Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like
93 | c2no2A_ |
| not modelled | 56.9 | 12 | PDB header:cell adhesion Chain: A: PDB Molecule:huntingtin-interacting protein 1; PDBTitle: crystal structure of the dllrkn-containing coiled-coil2 domain of huntingtin-interacting protein 1
94 | c2e4hA_ |
| not modelled | 56.6 | 27 | PDB header:structural protein Chain: A: PDB Molecule:restin; PDBTitle: solution structure of cytoskeletal protein in complex with2 tubulin tail
95 | d2e3ia1 |
| not modelled | 56.3 | 20 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
96 | c2rcnA_ |
| not modelled | 55.3 | 21 | PDB header:hydrolase Chain: A: PDB Molecule:probable gtpase engc; PDBTitle: crystal structure of the ribosomal interacting gtpase yjeq from the2 enterobacterial species salmonella typhimurium.
97 | c1e0tD_ |
| not modelled | 55.2 | 18 | PDB header:phosphotransferase Chain: D: PDB Molecule:pyruvate kinase; PDBTitle: r292d mutant of e. coli pyruvate kinase
98 | c2zdiA_ |
| not modelled | 55.1 | 12 | PDB header:chaperone Chain: A: PDB Molecule:prefoldin subunit beta; PDBTitle: crystal structure of prefoldin from pyrococcus horikoshii2 ot3
99 | d2cp3a1 |
| not modelled | 54.5 | 35 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
100 | d1h6za2 |
| not modelled | 54.3 | 38 | Fold:The "swivelling" beta/beta/alpha domain Superfamily:Phosphohistidine domain Family:Pyruvate phosphate dikinase, central domain
101 | d1vqoq1 |
| not modelled | 54.1 | 27 | Fold:SH3-like barrel Superfamily:Translation proteins SH3-like domain Family:Ribosomal proteins L24p and L21e
102 | c2p03A_ |
| not modelled | 54.1 | 10 | PDB header:cell adhesion Chain: A: PDB Molecule:alpha-2-macroglobulin receptor-associated PDBTitle: the structure of receptor-associated protein(rap)
103 | c2z0wA_ |
| not modelled | 53.7 | 20 | PDB header:protein binding Chain: A: PDB Molecule:cap-gly domain-containing linker protein 4; PDBTitle: crystal structure of the 2nd cap-gly domain in human restin-2 like protein 2 reveals a swapped-dimer
104 | d2cowa1 |
| not modelled | 53.7 | 32 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
105 | c1q46A_ |
| not modelled | 53.3 | 18 | PDB header:translation Chain: A: PDB Molecule:translation initiation factor 2 alpha subunit; PDBTitle: crystal structure of the eif2 alpha subunit from2 saccharomyces cerevisia
106 | c2v4hA_ |
| not modelled | 52.9 | 12 | PDB header:transcription Chain: A: PDB Molecule:nf-kappa-b essential modulator; PDBTitle: nemo cc2-lz domain - 1d5 darpin complex
107 | c3b7kA_ |
| not modelled | 52.7 | 21 | PDB header:hydrolase Chain: A: PDB Molecule:acyl-coenzyme a thioesterase 12; PDBTitle: human acyl-coenzyme a thioesterase 12
108 | c2wctC_ |
| not modelled | 52.7 | 37 | PDB header:rna-binding protein Chain: C: PDB Molecule:non-structural protein 3; PDBTitle: human sars coronavirus unique domain (triclinic form)
109 | d2essa1 |
| not modelled | 52.1 | 15 | Fold:Thioesterase/thiol ester dehydrase-isomerase Superfamily:Thioesterase/thiol ester dehydrase-isomerase Family:Acyl-ACP thioesterase-like
110 | c1hh2P_ |
| not modelled | 52.0 | 20 | PDB header:transcription regulation Chain: P: PDB Molecule:n utilization substance protein a; PDBTitle: crystal structure of nusa from thermotoga maritima
111 | d1yvca1 |
| not modelled | 51.9 | 19 | Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:TRAM domain
112 | d1ppje2 |
| not modelled | 51.5 | 22 | Fold:Single transmembrane helix Superfamily:ISP transmembrane anchor Family:ISP transmembrane anchor
113 | c3iz5U_ |
| not modelled | 51.4 | 24 | PDB header:ribosome Chain: U: PDB Molecule:60s ribosomal protein l21 (l21e); PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome
114 | d2o1ra1 |
| not modelled | 51.3 | 21 | Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like
115 | d1whha_ |
| not modelled | 51.3 | 24 | Fold:SH3-like barrel Superfamily:Cap-Gly domain Family:Cap-Gly domain
116 | c4a1aP_ |
| not modelled | 51.2 | 28 | PDB header:ribosome Chain: P: PDB Molecule:60s ribosomal protein l21; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna,3 5.8s rrna and proteins of molecule 3.
117 | c3a7pB_ |
| not modelled | 50.9 | 8 | PDB header:protein transport Chain: B: PDB Molecule:autophagy protein 16; PDBTitle: the crystal structure of saccharomyces cerevisiae atg16
118 | d2f9ha1 |
| not modelled | 50.8 | 26 | Fold:PTSIIA/GutA-like Superfamily:PTSIIA/GutA-like Family:PTSIIA/GutA-like
119 | c3dedB_ |
| not modelled | 50.4 | 8 | PDB header:membrane protein Chain: B: PDB Molecule:probable hemolysin; PDBTitle: c-terminal domain of probable hemolysin from chromobacterium violaceum
120 | d1y7ua1 |
| not modelled | 50.4 | 13 | Fold:Thioesterase/thiol ester dehydrase-isomerase Superfamily:Thioesterase/thiol ester dehydrase-isomerase Family:4HBT-like

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0