Supersites within superfolds: supplementary information

Supersites within superfolds
Binding site similarity in the absence of homology

The table below corresponds to Table 1 within the paper. Links from each fold name show the folds and superfamilies (as defined within SCOP version 1.35; N.B. this is not the same version that is currently on the SCOP WWW site) used during the analysis. They also provide a link to the transformation files used during the analysis. For more information about the format of the transformation files click here.

Fold name Class S Swh Z P P* i_max (O_i)

Rossmann-like alpha/beta 48 38 43.02 <1e-5 <0.001 20 (2)

Beta-alpha_barrel alpha/beta 16 16 21.23 <1e-5 <0.001 12 (1)

Beta_propeller all beta 6 5 5.45 <1e-5 <0.001 4 (2)

Rubredoxin-like SDS 4 4 4.28 <1e-5 <0.001 3 (1)

DNA binding three-helical bundle all alpha 3 2 3.65 0.0013 0.005 2 (25)

SH2-like alpha+beta 2 2 2.47 0.007 0.004 2 (12)

Ferredoxin-like alpha+beta 37 23 3.17 0.0008 0.02 8 (2)

Double stranded beta helix all beta 3 3 3.08 0.001 0.01 3 (2)

Four helix bundle all alpha 6 5 2.82 0.002 0.01 5 (1)

Knottin-like SDS 11 7 1.87 0.03 0.08 4 (1)

Ribonuclease-H-like alpha/beta 4 2 1.36 0.09 0.08 2 (17)

Beta grasp alpha+beta 6 5 1.51 0.06 0.10 2 (6)

Colipase_domain-like all beta 5 3 1.19 0.12 0.13 2 (13)

Swivelling beta-beta-alpha domain alpha/beta 3 2 0.77 0.22 0.14 1 (2)

Ig-like all beta 21 13 1.10 0.15 0.17 6 (2)

EF-hand all alpha 2 2 -0.07 - - 2 (28)

Barrel-sandwich hybrid all beta 3 3 -0.03 - - 2 (1)

Profilin-like alpha+beta 2 2 -0.22 - - 1 (9)

Jelly_rolls all beta 12 10 -0.56 - - 5 (1)

Beta trefoil all beta 4 2 -0.75 0.22 0.18 1 (18)

OB fold all beta 5 3 -1.18 0.12 0.14 2 (3)

SH3-like barrel all beta 6 3 -1.28 0.10 0.14 2 (2)

Cystatin-like alpha+beta 4 3 -1.45 0.07 0.08 1 (28)

Calycin-like all beta 4 4 -1.53 0.06 0.07 3 (1)

Supersandwich all beta 2 1 - - - 1 (5)

A dom F1 ATP synthase all beta 2 1 - - - 1 (1)

dsRBD/PDA domains alpha+beta 2 1 - - - 1 (1)

Metzincin-like alpha+beta 2 1 - - - 1 (47)

Globin-like all alpha 3 1 - - - 1 (51)

single stranded right-handed beta helix all beta 2 0 - - - 0 (63)

IF3-like alpha+beta 2 0 - - - 0 (63)

beta prism I all beta 2 0 - - - 0 (63)

Fold name	Class	S	Swh	Z	P	P*	i_max (O_i)
Rossmann-like	alpha/beta	48	38	43.02	<1e-5	<0.001	20 (2)
Beta-alpha_barrel	alpha/beta	16	16	21.23	<1e-5	<0.001	12 (1)
Beta_propeller	all beta	6	5	5.45	<1e-5	<0.001	4 (2)
Rubredoxin-like	SDS	4	4	4.28	<1e-5	<0.001	3 (1)
DNA binding three-helical bundle	all alpha	3	2	3.65	0.0013	0.005	2 (25)
SH2-like	alpha+beta	2	2	2.47	0.007	0.004	2 (12)
Ferredoxin-like	alpha+beta	37	23	3.17	0.0008	0.02	8 (2)
Double stranded beta helix	all beta	3	3	3.08	0.001	0.01	3 (2)
Four helix bundle	all alpha	6	5	2.82	0.002	0.01	5 (1)
Knottin-like	SDS	11	7	1.87	0.03	0.08	4 (1)
Ribonuclease-H-like	alpha/beta	4	2	1.36	0.09	0.08	2 (17)
Beta grasp	alpha+beta	6	5	1.51	0.06	0.10	2 (6)
Colipase_domain-like	all beta	5	3	1.19	0.12	0.13	2 (13)
Swivelling beta-beta-alpha domain	alpha/beta	3	2	0.77	0.22	0.14	1 (2)
Ig-like	all beta	21	13	1.10	0.15	0.17	6 (2)
EF-hand	all alpha	2	2	-0.07	-	-	2 (28)
Barrel-sandwich hybrid	all beta	3	3	-0.03	-	-	2 (1)
Profilin-like	alpha+beta	2	2	-0.22	-	-	1 (9)
Jelly_rolls	all beta	12	10	-0.56	-	-	5 (1)
Beta trefoil	all beta	4	2	-0.75	0.22	0.18	1 (18)
OB fold	all beta	5	3	-1.18	0.12	0.14	2 (3)
SH3-like barrel	all beta	6	3	-1.28	0.10	0.14	2 (2)
Cystatin-like	alpha+beta	4	3	-1.45	0.07	0.08	1 (28)
Calycin-like	all beta	4	4	-1.53	0.06	0.07	3 (1)
Supersandwich	all beta	2	1	-	-	-	1 (5)
A dom F1 ATP synthase	all beta	2	1	-	-	-	1 (1)
dsRBD/PDA domains	alpha+beta	2	1	-	-	-	1 (1)
Metzincin-like	alpha+beta	2	1	-	-	-	1 (47)
Globin-like	all alpha	3	1	-	-	-	1 (51)
single stranded right-handed beta helix	all beta	2	0	-	-	-	0 (63)
IF3-like	alpha+beta	2	0	-	-	-	0 (63)
beta prism I	all beta	2	0	-	-	-	0 (63)

Supersites within superfolds Binding site similarity in the absence of homology

Supersites within superfolds
Binding site similarity in the absence of homology