Alignment of thymidine_kinase with 1tfr-0

Alignment of thymidine_kinase with 1tfr-0

PSSM Score Key
-10																			10

Bad																			Good

thymid_PSS	Predicted Secondary Structure for your Sequence
thymid_Seq	Your Sequence
1tfr-0_Seq	Library Sequence
1tfr-0_SS	Known Secondary Structure of the Library Sequence (Assigned by STRIDE)
CORE	A measure of the burial and number of contacts made by a residue. (9 very buried/making many contacts, 0 not buried/making few contacts

thymid_PSS

C

C

.

.

.

.

.

.

.

.

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

C

E

E

E

E

E

E

E

E

E

C

C

C

C

H

H

H

H

H

H

H

H

.

H

H

thymid_Seq

M

S

.

.

.

.

.

.

.

.

C

I

N

L

P

T

V

L

P

G

S

P

S

K

T

R

G

Q

I

Q

V

I

L

G

P

M

F

S

G

K

S

T

E

L

M

R

R

.

V

R

-------

-

-

I

-

L

-

T

-

L

-

-

P

K

-

+

-

-

+

M

-

-

-

-

-

-

+

-

+

V

1tfr-0_Seq

K

E

G

I

C

L

I

D

F

S

Q

I

A

L

S

T

A

L

V

N

F

P

D

K

E

K

I

N

L

S

.

.

.

.

.

M

V

R

H

L

I

L

N

S

I

K

F

N

V

K

1tfr-0_SS

C

C

E

E

E

E

E

E

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

C

C

C

C

C

H

H

.

.

.

.

.

H

H

H

H

H

H

H

H

H

H

H

H

H

H

H

CORE

0

0

0

4

3

9

4

0

4

0

0

2

2

0

0

0

1

0

0

0

1

0

0

0

0

0

1

0

0

0

.

.

.

.

.

0

2

0

0

1

4

5

0

0

5

0

0

0

4

0

thymid_PSS

H

H

H

H

C

C

C

E

E

E

E

E

E

E

C

C

C

C

C

C

C

C

C

E

E

E

E

C

.

.

.

.

.

C

C

C

C

C

.

.

.

.

C

C

C

C

C

C

H

H

thymid_Seq

R

F

Q

I

A

Q

Y

K

C

L

V

I

K

Y

A

K

D

T

R

Y

S

S

S

F

C

T

H

D

.

.

.

.

.

R

N

T

M

E

.

.

.

.

A

L

P

A

C

L

L

R

-------

-

-

-

+

Y

-

-

+

V

+

+

D

-

+

S

+

+

-

-

-

D

+

T

-

+

-

+

-

-

-

+

-

1tfr-0_Seq

K

A

K

T

L

G

Y

T

K

I

V

L

.

.

C

I

D

N

.

A

K

S

G

Y

W

R

R

D

F

A

Y

Y

Y

K

K

T

W

D

W

E

G

Y

F

E

S

S

H

K

V

I

1tfr-0_SS

H

H

H

H

H

C

C

C

E

E

E

E

.

.

E

C

C

E

.

C

C

C

C

C

H

H

H

H

C

C

C

C

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

CORE

0

5

0

0

0

0

1

0

0

4

7

6

.

.

6

2

0

0

.

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

0

0

0

1

0

0

2

2

thymid_PSS

H

H

H

H

H

H

C

C

E

E

E

E

E

E

E

C

C

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

C

C

C

E

E

E

E

E

C

C

C

C

C

H

H

H

.

C

thymid_Seq

D

V

A

Q

E

A

L

G

V

A

V

I

G

I

D

E

G

Q

F

F

P

D

I

M

E

F

C

E

A

M

A

N

A

G

K

T

V

I

V

A

A

L

D

G

T

F

Q

R

.

K

-------

D

-

-

+

+

+

+

+

V

+

I

D

-

-

-

-

-

-

I

-

-

+

-

-

+

+

G

-

-

+

+

+

-

-

D

G

-

F

-

-

1tfr-0_Seq

D

E

L

K

A

Y

M

P

Y

I

V

M

D

I

D

K

Y

E

A

D

D

H

I

A

V

L

V

K

K

F

S

L

E

G

H

K

I

L

I

I

S

S

D

G

D

F

T

Q

L

H

1tfr-0_SS

H

H

H

H

H

H

C

C

C

E

E

E

C

C

C

C

E

C

H

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

C

E

E

E

E

E

C

C

C

H

H

H

H

H

H

C

CORE

0

0

7

0

0

0

3

1

1

2

4

4

0

1

0

0

0

0

2

0

0

0

7

3

2

7

9

0

0

3

3

0

0

0

0

0

7

2

7

4

0

0

0

0

0

2

0

0

7

0

thymid_PSS

C

C

C

C

H

H

H

H

H

H

H

H

H

H

H

H

H

C

C

H

H

H

H

H

H

C

C

C

C

C

E

E

E

E

E

C

C

C

C

E

E

E

E

E

C

C

C

C

C

C

thymid_Seq

P

F

G

A

I

L

N

L

V

P

L

A

E

S

V

V

K

L

T

A

V

C

M

E

C

F

R

E

A

A

Y

T

K

R

L

G

T

E

K

E

V

E

V

I

G

G

A

D

K

Y

-------

-

+

-

-

+

-

-

+

-

P

-

V

K

-

-

-

-

C

-

T

K

-

L

-

-

K

-

-

-

V

-

+

-

-

-

-

1tfr-0_Seq

K

Y

P

N

V

K

Q

W

S

P

M

H

K

K

W

V

K

I

G

S

A

E

I

D

C

.

.

.

.

.

M

T

K

I

L

K

G

D

K

K

D

N

V

A

S

V

K

V

R

.

1tfr-0_SS

C

C

C

C

E

E

E

E

E

C

C

C

C

E

E

C

C

C

H

H

H

H

H

H

H

.

.

.

.

.

H

H

H

H

H

H

C

E

H

H

H

C

E

C

C

C

C

C

C

.

CORE

0

0

0

0

8

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

.

.

.

.

.

1

0

0

0

4

0

0

0

0

0

0

0

0

0

0

3

0

0

0

.

thymid_PSS		H	H	H	H	H	H	H	C	C	.		.	.	.	.	C	C	C	C	C	.		.	.	.	.	.	.	.	.	C	C		C	C	C	C	C	C	C	C	C	.		.	.	.	.	.	.	.	.	.	.
thymid_Seq		H	S	V	C	R	L	C	Y	F	.		.	.	.	.	K	K	A	S	G	.		.	.	.	.	.	.	.	.	Q	P		A	G	P	D	N	K	E	N	C	.		.	.	.	.	.	.	.	.	.	.
-------						-	-	-	+	F								+		-												-	-		-	-	-	-	-	K		-	-
1tfr-0_Seq		.	.	.	.	S	D	F	W	F	T		R	V	E	G	E	R	T	P	S	M		K	T	S	I	V	E	A	I	A	N		D	R	E	Q	A	K	V	L	L	T		E	S	E	Y	N	R	Y	K	E	N
1tfr-0_SS		.	.	.	.	C	C	H	H	H	C		C	C	C	C	C	C	C	C	C	C		C	H	H	H	H	H	H	H	H	H		C	H	H	H	H	H	H	H	C	C		H	H	H	H	H	H	H	H	H	H
CORE		.	.	.	.	0	0	0	0	0	0		0	0	0	0	0	0	0	0	0	2		0	0	0	2	2	0	0	3	1	0		0	0	0	0	2	0	0	1	4	0		0	0	0	0	0	0	1	0	0	0

thymid_PSS		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		.	.	.	C	C	C	C	C	C	C		H	H	H	H	H	H	H	H	C	C		C	H	H	H	H	C	C	C	C	C
thymid_Seq		.	.	.	.	.	.	.	.	.	.		.	.	.	.	.	.	.	.	.	.		.	.	.	P	V	P	G	K	P	G		E	A	V	A	A	R	K	L	F	A		P	Q	Q	I	L	Q	C	S	P	A
-------																											-	-	+	-	-	-	G			-	-	+	-	-		-	-	-		-	-		+	+		-	-	-	-
1tfr-0_Seq		L	V	L	I	D	F	D	Y	I	P		D	N	I	A	S	N	I	V	N	Y		Y	N	S	Y	K	L	P	P	R	G		K	I	Y	S	Y	F	V	K	A	G		L	S	K	L	T	N	S	I	N	E
1tfr-0_SS		H	H	H	H	C	H	H	H	C	C		H	H	H	H	H	H	H	H	H	H		H	H	H	C	C	C	C	C	C	H		H	H	H	H	H	H	H	H	H	C		C	H	H	H	C	C	C	H	H	H
CORE		0	0	0	0	0	2	0	0	2	0		0	0	0	1	0	0	3	2	0	0		2	0	0	0	0	0	0	0	0	0		0	2	0	0	1	3	0	0	0	0		2	0	0	3	0	0	0	1	0	0

thymid_PSS		C
thymid_Seq		N
-------		-
1tfr-0_Seq		F
1tfr-0_SS		C
CORE		5