Job Description Undefined Confidence 99.90% Date Thu Nov 13 08:26:15 GMT 2025 Rank 170 Aligned Residues 286 % Identity 14% Template c6v7nB_ PDB info PDB header: hydrolase Chain: B: PDB Molecule: Lysosomal acid lipase/cholesteryl ester hydrolase PDBTitle: ;crystal structure of a human lysosome resident glycoprotein, lysosomal acid lipase, and its implications in cholesteryl ester storage disease (cesd); PDB Entry: PDBe RCSB PDBj Resolution UNK

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		28	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50			.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70							.	.	.	.	.	.	.		.
Predicted Secondary structure																									.	.																					.	.	.	.	.	.								.
Query Sequence		P	Q	V	H	Y	R	V	E	Q	V	G	D	V	K	V	F	Y	R	E	A	G	D	P	.	.	A	A	P	A	V	L	L	L	H	G	F	A	A	S	S	Y	M	W	R	D	.	.	.	.	.	.	V	I	E	A	L	A	D	.	G
Query Conservation																									.	.																					.	.	.	.	.	.								.
Alig confidence																									.	.																					.	.	.	.	.	.								.
Template Conservation
Template Sequence		P	S	E	E	Y	L	V	E	T	E	D	G	Y	I	L	C	L	N	R	I	P	H	G	R	K	P	K	P	V	V	F	L	Q	H	G	L	L	A	D	S	S	N	W	V	T	N	L	A	Q	S	S	L	G	F	I	L	A	D	A	G
Template Known Secondary structure											T	T	S										S		S	S	S	.	.								T	T			G	G	G	G	S	S	S		T	T	T	S								T	T
Template Predicted Secondary structure
		79	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.												.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.
Predicted Secondary structure																													.	.	.	.	.	.	.	.	.	.	.
Query Sequence		Y	H	V	I	A	P	D	L	P	A	F	G	Y	T	E	A	P	A	R	G	Q	Y	D	Y	T	F	A	.	.	.	.	.	.	.	.	.	.	.	N	L	T	K	T	I	E	R	F	T	D	Q	L	K	L	T	R	Y	A	M	A	V
Query Conservation																													.	.	.	.	.	.	.	.	.	.	.
Alig confidence																													.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		F	D	V	W	M	G	N	S	R	G	N	T	W	S	R	K	H	K	T	L	S	V	S	Q	D	E	F	W	A	F	S	Y	D	E	M	A	K	Y	D	L	P	A	S	I	N	F	I	L	N	K	T	G	Q	E	Q	V	Y	Y	V	G
Template Known Secondary structure										T	T	S	T	T	S				S	S			T	T	S	G	G	G	G																										S
Template Predicted Secondary structure
		128	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.				.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.
Predicted Secondary structure																			.	.	.
Query Sequence		H	D	Y	G	A	P	V	G	W	R	L	A	L	A	H	P	S	.	.	.	R	I	T	A	I	I	S	Q	N	G	N	A	Y	E	E	G	L	S	A	G	W	E	P	I	R	K	Y	W	N	D	P	T	A	E	N	R	Q	A	L	S
Query Conservation																			.	.	.
Alig confidence																			.	.	.
Template Conservation
Template Sequence		H	S	Q	G	T	T	I	G	F	I	A	F	S	Q	I	P	E	L	A	K	R	I	K	M	F	F	A	L	G	P	V	A	S	V	A	F	C	T	S	P	M	A	K	L	G	R	L	P	D	H	L	I	K	D	L	F	G	D	K	E
Template Known Secondary structure																					T	T											S			T	T			S							T	S											S	S	B
Template Predicted Secondary structure
		185	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.																			.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.
Predicted Secondary structure																			.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		D	F	P	T	P	A	S	I	K	W	Q	Y	V	E	G	V	S	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	D	T	S	L	V	A	P	D	A	Y	T	L	E	G	A	Q	I	L	R	P	G	M	A	D	I
Query Conservation																			.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																			.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		F	L	P	Q	S	A	F	L	K	W	L	G	T	H	V	C	T	H	V	I	L	K	E	L	C	G	N	L	C	F	L	L	C	G	F	N	E	R	N	L	N	M	S	R	V	D	V	Y	T	T	H	S	P	A	G	T	S	V	Q	N
Template Known Secondary structure													T	T	T	S		S	S		S	S	S	G	G	G	S	S										G	G	G	S		T	T	S													B
Template Predicted Secondary structure
		227	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.																	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270
Predicted Secondary structure																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		Q	L	D	L	L	L	D	Y	A	T	N	V	E	Q	Y	P	A	F	Q	A	Y	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	F	R	E	Y	Q	P	P	L	L	A	V	W	G	E	H	D	P	F	F	L	P	P	G
Query Conservation																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		M	L	H	W	S	Q	A	V	K	F	Q	K	F	Q	A	F	D	W	G	S	S	A	K	N	Y	F	H	Y	Q	Q	S	Y	P	P	T	Y	N	V	K	D	M	L	V	P	T	A	V	W	S	G	G	H	D	W	L	A	D	V	Y	D
Template Known Secondary structure															B					S	S									S	S	S	S	.	.	B	.		G	G	G			S								T	T		S	S	S
Template Predicted Secondary structure
		271	.	.	.	.	.	.	.	.	280	.	.			.	.	.	.	.	.	.	290	.	.	.	.				.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.
Predicted Secondary structure														.	.													.	.	.
Query Sequence		A	E	A	W	K	R	D	I	P	D	A	D	.	.	I	R	L	Y	D	T	G	H	F	A	L	E	.	.	.	T	H	S	E	V	I	I	P	T	I	R	Q	F	L	D	D	H	V	S
Query Conservation														.	.													.	.	.
Alig confidence														.	.													.	.	.
Template Conservation
Template Sequence		V	N	I	L	L	T	Q	I	T	N	L	V	F	H	E	S	I	P	E	W	E	H	L	D	F	I	W	G	L	D	A	P	W	R	L	Y	N	K	I	I	N	L	M	R	K	Y	Q	A
Template Known Secondary structure							T	T		T	T								T	T			T	T						T	T
Template Predicted Secondary structure

No model constructed - rank, confidence too low

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Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction
Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960
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