Job Description Undefined Confidence 99.75% Date Thu Nov 13 08:26:15 GMT 2025 Rank 435 Aligned Residues 187 % Identity 15% Template c5synA_ PDB info PDB header: hydrolase/hydrolase inhibitor Chain: A: PDB Molecule: Acyl-protein thioesterase 2 PDBTitle: cocrystal structure of the human acyl protein thioesterase 2 with an isoform-selective inhibitor, ml349 PDB Entry: PDBe RCSB PDBj Resolution UNK

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		42	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.		.	.	80	.	.	.	.	.	.	.	.
Predicted Secondary structure																																						.												.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		V	F	Y	R	E	A	G	D	P	A	A	P	A	V	L	L	L	H	G	F	A	A	S	S	Y	M	W	R	D	V	I	E	A	L	A	D	.	G	Y	H	V	I	A	P	D	L	P	A	.	.	.	.	.	.	.	.	.	.	.	.
Query Conservation																																						.												.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																																						.												.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		A	A	T	V	S	G	A	E	R	E	T	A	A	V	I	F	L	H	G	L	G	D	T	G	H	S	W	A	D	A	L	S	T	I	R	L	P	H	V	K	Y	I	C	P	H	A	P	R	I	P	V	T	L	N	M	K	M	V	M	P
Template Predicted Secondary structure
							89	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.						.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.
Predicted Secondary structure		.	.	.	.	.																														.	.	.	.	.
Query Sequence		.	.	.	.	.	F	G	Y	T	E	A	P	A	R	G	Q	Y	D	Y	T	F	A	N	L	T	K	T	I	E	R	F	T	D	Q	.	.	.	.	.	L	K	L	T	R	Y	A	M	A	V	H	D	Y	G	A	P	V	G	W	R	L
Query Conservation		.	.	.	.	.																														.	.	.	.	.
Alig confidence		.	.	.	.	.					.	.																								.	.	.	.	.
Template Conservation											.	.
Template Sequence		S	W	F	D	L	M	G	L	S	.	.	P	D	A	P	E	D	E	A	G	I	K	K	A	A	E	N	I	K	A	L	I	E	H	E	M	K	N	G	I	P	A	N	R	I	V	L	G	G	F	S	Q	G	G	A	L	S	L	Y	T
Template Predicted Secondary structure											.	.
		139	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query Sequence		A	L	A	H	P	S	R	I	T	A	I	I	S	Q	N	G	N	A	Y	E	E	G	L	S	A	G	W	E	P	I	R	K	Y	W	N	D	P	T	A	E	N	R	Q	A	L	S	D	F	P	T	P	A	S	I	K	W	Q	Y	V	E
Query Conservation
Alig confidence																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		A	L	T	C	P	H	P	L	A	G	I	V	A	L	S	C	W	L	P	L	H	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
		199	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query Sequence		G	V	S	D	T	S	L	V	A	P	D	A	Y	T	L	E	G	A	Q	I	L	R	P	G	M	A	D	I	Q	L	D	L	L	L	D	Y	A	T	N	V	E	Q	Y	P	A	F	Q	A	Y	F	R	E	Y	Q	P	P	L	L	A	V
Query Conservation
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	R	A	F	P	Q	A	A	N	G	S	A	K	D	L	A	I	L	Q	C
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
		259	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280							.	.	.		.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.
Predicted Secondary structure																								.	.	.	.	.	.				.
Query Sequence		W	G	E	H	D	P	F	F	L	P	P	G	A	E	A	W	K	R	D	I	P	D	.	.	.	.	.	.	A	D	I	.	R	L	Y	D	T	G	H	F	A	L	E	T	H	S	E	V	I	I	P	T	I	R	Q	F	L	D	D	H
Query Conservation																								.	.	.	.	.	.				.
Alig confidence																								.	.	.	.	.	.				.											.	.	.	.
Template Conservation																																												.	.	.	.
Template Sequence		H	G	E	L	D	P	M	V	P	V	R	F	G	A	L	T	A	E	K	L	R	S	V	V	T	P	A	R	V	Q	F	K	T	Y	P	G	V	M	H	S	S	C	.	.	.	.	P	Q	E	M	A	A	V	K	E	F	L	E	K	L
Template Predicted Secondary structure																																												.	.	.	.
		312	.	.
Predicted Secondary structure
Query Sequence		V	S	L
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	P	P
Template Predicted Secondary structure

No model constructed - rank, confidence too low

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Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960
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