Job Description Undefined Confidence 99.96% Date Thu Nov 13 08:26:15 GMT 2025 Rank 15 Aligned Residues 278 % Identity 22% Template c5cw2A_ PDB info PDB header: hydrolase Chain: A: PDB Molecule: Putative epoxide hydrolase EPHA PDBTitle: crystal structure of epoxide hydrolase a from mycobacterium thermoresistibile PDB Entry: PDBe RCSB PDBj Resolution UNK Model Dimensions (Å) X:47.011 Y:49.943 Z:50.355

Show / Hide SS confidence

Show / Hide Conservation and Alignment quality

33

.

.

.

.

.

.

40

.

.

.

.

.

.

.

.

.

50

.

.

.

.

.

.

.

.

.

60

.

.

.

.

.

.

.

.

.

70

.

.

.

.

.

.

.

.

.

80

.

.

.

.

.

.

.

.

.

90

.

Predicted Secondary structure

.

Query Sequence

R

V

E

Q

V

G

D

V

K

V

F

Y

R

E

A

G

D

P

A

A

P

A

V

L

L

L

H

G

F

A

A

S

S

Y

M

W

R

D

V

I

E

A

L

A

D

G

.

Y

H

V

I

A

P

D

L

P

A

F

G

Y

Query Conservation

.

Alig confidence

.

Template Conservation

Template Sequence

R

S

V

E

T

N

G

V

R

L

R

L

V

E

A

G

E

R

G

D

P

L

V

V

L

A

H

G

F

P

E

L

A

Y

S

W

R

H

Q

I

P

A

L

V

D

A

G

Y

H

V

M

A

P

D

Q

R

G

Y

G

G

Template Known Secondary structure

T

T

S

T

T

S

.

T

T

G

G

G

G

T

T

T

T

T

.

T

T

S

T

T

Template Predicted Secondary structure

92

.

.

.

.

.

.

.

100

.

.

.

.

.

.

.

.

.

110

.

.

.

.

.

.

.

.

.

120

.

.

.

.

.

.

.

.

.

130

.

.

.

.

.

.

.

.

.

140

.

.

.

.

.

.

.

.

.

150

.

Predicted Secondary structure

Query Sequence

T

E

A

P

A

R

G

Q

Y

D

Y

T

F

A

N

L

T

K

T

I

E

R

F

T

D

Q

L

K

L

T

R

Y

A

M

A

V

H

D

Y

G

A

P

V

G

W

R

L

A

L

A

H

P

S

R

I

T

A

I

I

S

Query Conservation

Alig confidence

.

Template Conservation

.

Template Sequence

S

S

A

P

E

A

I

E

.

A

Y

D

I

T

R

L

T

A

D

L

M

G

L

L

D

D

I

G

A

E

K

A

A

F

I

G

H

D

W

G

A

L

V

V

W

N

A

A

L

L

Y

P

D

R

V

A

A

V

A

G

Template Known Secondary structure

S

S

S

G

.

G

G

S

T

T

S

T

T

T

T

Template Predicted Secondary structure

.

152

.

.

.

.

.

.

.

160

.

.

.

.

.

.

.

.

.

170

.

.

.

.

.

.

.

.

.

180

.

.

.

.

.

.

.

.

.

190

.

Predicted Secondary structure

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

Query Sequence

Q

N

G

N

A

Y

E

E

G

L

S

A

G

W

E

P

I

R

K

Y

W

N

D

P

T

A

E

N

R

Q

A

L

S

D

F

P

T

P

A

S

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

Query Conservation

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

Alig confidence

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

Template Conservation

Template Sequence

L

S

V

P

P

V

P

R

S

L

T

R

P

T

E

A

F

R

A

L

V

G

E

D

N

F

F

Y

I

L

Y

F

Q

E

P

G

V

A

D

A

E

L

D

G

D

P

A

R

T

M

R

R

M

F

G

G

L

T

S

D

Template Known Secondary structure

S

S

.

.

.

.

.

S

S

T

T

T

S

T

T

S

T

T

Template Predicted Secondary structure

192

.

.

.

.

.

.

.

200

.

.

.

.

.

.

.

.

.

210

.

.

.

.

.

.

.

.

.

220

.

.

.

.

.

.

.

.

.

230

.

.

.

.

.

.

.

Predicted Secondary structure

.

.

.

.

.

.

.

.

.

.

.

.

.

.

Query Sequence

.

.

.

.

.

.

.

.

.

.

.

.

.

.

I

K

W

Q

Y

V

E

G

V

S

D

T

S

L

V

A

P

D

A

Y

T

L

E

G

A

Q

I

L

R

P

G

M

A

D

I

Q

L

D

L

L

L

D

Y

A

T

N

Query Conservation

.

.

.

.

.

.

.

.

.

.

.

.

.

.

Alig confidence

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

Template Conservation

.

Template Sequence

P

D

A

A

H

R

M

L

Q

P

G

P

A

G

F

I

D

R

L

P

E

P

E

A

L

P

D

W

L

T

A

E

E

L

D

H

Y

I

A

E

F

T

R

T

G

F

T

G

G

L

N

W

Y

R

N

M

D

R

N

.

Template Known Secondary structure

S

S

S

S

S

S

T

T

S

T

T

.

Template Predicted Secondary structure

.

238

.

240

.

.

.

.

.

.

.

.

.

250

.

.

.

.

.

.

.

.

.

260

.

.

.

.

.

.

.

.

.

270

.

.

.

.

.

.

.

.

.

280

.

.

.

.

.

.

.

.

.

290

.

.

.

.

.

Predicted Secondary structure

.

.

Query Sequence

V

E

Q

Y

P

A

F

Q

A

Y

F

R

E

Y

Q

P

P

L

L

A

V

W

G

E

H

D

P

F

F

L

P

P

G

A

E

A

W

K

R

D

I

P

D

A

D

.

.

I

R

L

Y

D

T

G

H

F

A

L

E

T

Query Conservation

.

.

Alig confidence

.

.

.

.

Template Conservation

.

.

Template Sequence

.

.

W

E

L

T

E

H

L

A

G

A

T

I

T

A

P

A

L

F

L

A

G

A

A

D

P

V

L

G

F

M

R

P

E

R

A

T

E

V

A

V

G

P

Y

R

Q

V

L

L

D

G

A

G

H

W

V

Q

Q

E

Template Known Secondary structure

.

.

T

T

G

G

G

S

S

B

S

T

T

G

G

G

G

T

S

T

T

G

G

G

T

B

S

S

T

T

S

Template Predicted Secondary structure

.

.

296

.

.

.

300

.

.

.

.

.

.

.

.

.

310

.

.

.

.

Predicted Secondary structure

Query Sequence

H

S

E

V

I

I

P

T

I

R

Q

F

L

D

D

H

V

S

L

Query Conservation

Alig confidence

Template Conservation

Template Sequence

R

P

Q

E

V

N

A

A

L

I

D

F

L

R

G

L

E

L

Q

Template Known Secondary structure

S

T

T

Template Predicted Secondary structure

---

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction
Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960
© Structural Bioinformatics Group, Imperial College, London Michael Sternberg   Disclaimer Terms and Conditions		Phyre2 is part of Genome3D