Job Description Undefined Confidence 99.98% Date Thu Nov 13 08:26:15 GMT 2025 Rank 74 Aligned Residues 283 % Identity 18% Template c4yx9D_ PDB info PDB header: hydrolase/hydrolase inhibitor Chain: D: PDB Molecule: CFTR inhibitory factor PDBTitle: crystal structure of the cftr inhibitory factor cif bound to tiratricol PDB Entry: PDBe RCSB PDBj Resolution UNK

Show / Hide SS confidence

Show / Hide Conservation and Alignment quality

21

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30

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40

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50

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60

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70

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80

Predicted Secondary structure

Query Sequence

G

G

R

A

S

A

A

P

Q

V

H

Y

R

V

E

Q

V

G

D

V

K

V

F

Y

R

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A

G

D

P

A

A

P

A

V

L

L

L

H

G

F

A

A

S

S

Y

M

W

R

D

V

I

E

A

L

A

D

G

Y

H

Query Conservation

Alig confidence

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Template Conservation

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Template Sequence

A

E

E

F

P

V

P

N

G

F

E

S

A

Y

R

E

V

D

G

V

K

L

H

Y

V

K

G

G

Q

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G

P

L

V

M

L

V

H

G

F

G

Q

T

W

Y

E

W

H

Q

L

M

P

E

L

A

K

R

F

T

Template Known Secondary structure

S

S

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T

T

T

T

S

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S

S

T

T

G

G

G

G

T

T

T

T

T

S

Template Predicted Secondary structure

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81

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90

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100

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110

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120

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130

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Predicted Secondary structure

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Query Sequence

V

I

A

P

D

L

P

A

F

G

Y

T

E

A

P

A

R

G

Q

Y

D

Y

T

F

A

N

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T

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T

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E

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T

D

Q

L

K

L

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Y

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A

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Y

G

A

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V

G

W

R

L

A

Query Conservation

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Alig confidence

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Template Conservation

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Template Sequence

V

I

A

P

D

L

P

G

L

G

Q

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E

P

P

K

T

G

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Y

S

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Q

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A

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L

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P

D

R

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F

D

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H

D

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G

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N

T

Y

P

M

V

Template Known Secondary structure

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T

T

S

T

T

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S

S

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S

S

S

S

S

T

T

T

Template Predicted Secondary structure

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140

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150

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160

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170

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180

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190

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Predicted Secondary structure

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Query Sequence

L

A

H

P

S

R

I

T

A

I

I

S

Q

N

G

N

A

Y

E

E

G

L

S

A

G

W

E

P

I

R

K

Y

W

N

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D

P

T

A

E

N

R

Q

A

L

S

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F

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T

P

A

S

Query Conservation

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Alig confidence

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Template Conservation

Template Sequence

V

K

N

Q

A

D

I

A

R

L

V

Y

M

E

A

P

I

P

D

A

R

I

Y

R

F

P

A

F

T

A

Q

G

E

S

L

V

W

H

F

S

F

F

A

A

D

D

R

L

A

E

T

L

I

A

G

K

E

R

F

F

Template Known Secondary structure

T

G

G

G

S

S

S

S

G

G

G

G

G

S

S

T

T

S

S

T

S

T

T

T

T

Template Predicted Secondary structure

192

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200

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210

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220

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230

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240

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250

.

Predicted Secondary structure

Query Sequence

I

K

W

Q

Y

V

E

G

V

S

D

T

S

L

V

A

P

D

A

Y

T

L

E

G

A

Q

I

L

R

P

G

M

A

D

I

Q

L

D

L

L

L

D

Y

A

T

N

V

E

Q

Y

P

A

F

Q

A

Y

F

R

E

Y

Query Conservation

Alig confidence

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Template Conservation

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Template Sequence

L

E

H

F

I

K

S

H

A

S

N

T

E

V

F

S

E

R

L

L

D

L

Y

A

R

S

Y

A

K

P

H

S

L

N

A

S

F

E

Y

Y

R

A

L

N

E

S

V

R

Q

N

A

E

L

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A

K

T

R

L

Template Known Secondary structure

T

S

G

G

G

S

T

S

T

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T

T

S

B

Template Predicted Secondary structure

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252

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260

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270

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280

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290

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300

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310

Predicted Secondary structure

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Query Sequence

Q

P

P

L

L

A

V

W

G

E

H

D

P

F

F

L

P

P

G

A

E

A

W

K

R

D

I

P

D

A

D

I

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R

L

Y

D

T

G

H

F

A

L

E

T

H

S

E

V

I

I

P

T

I

R

Q

F

L

D

D

Query Conservation

.

Alig confidence

.

Template Conservation

Template Sequence

Q

M

P

T

M

T

L

A

G

G

G

H

G

G

M

G

T

F

Q

L

E

Q

M

K

A

Y

A

E

D

V

E

G

H

V

L

P

G

C

G

H

W

L

P

E

E

C

A

A

P

M

N

R

L

V

I

D

F

L

S

R

Template Known Secondary structure

S

S

T

T

T

T

B

S

S

T

T

S

T

Template Predicted Secondary structure

No model constructed - rank, confidence too low

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction
Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960
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