Job Description Undefined Confidence 99.94% Date Thu Nov 13 08:26:15 GMT 2025 Rank 223 Aligned Residues 266 % Identity 14% Template c3c5vA_ PDB info PDB header: hydrolase Chain: A: PDB Molecule: Protein phosphatase methylesterase 1 PDBTitle: pp2a-specific methylesterase apo form (pme) PDB Entry: PDBe RCSB PDBj Resolution UNK

Show / Hide SS confidence

Show / Hide Conservation and Alignment quality

31

.

.

.

.

.

.

.

.

40

.

.

.

.

.

.

.

.

.

50

.

.

.

.

.

.

.

.

.

60

.

.

.

.

.

.

.

.

.

70

.

.

.

.

.

.

.

.

.

80

.

.

.

.

.

.

.

.

Predicted Secondary structure

.

.

Query Sequence

H

Y

R

V

E

Q

V

G

D

V

K

V

F

Y

R

E

A

G

D

P

A

A

P

A

V

L

L

L

H

G

F

A

A

S

S

Y

M

W

R

D

V

I

E

A

L

A

D

G

.

.

Y

H

V

I

A

P

D

L

P

A

Query Conservation

.

.

Alig confidence

.

.

Template Conservation

Template Sequence

D

V

E

V

E

N

E

T

G

K

D

T

F

R

V

Y

K

S

G

S

E

G

P

V

L

L

L

L

H

G

G

G

H

S

A

L

S

W

A

V

F

T

A

A

I

I

S

R

V

Q

C

R

I

V

A

L

D

L

R

S

Template Known Secondary structure

T

T

S

S

S

T

T

G

G

G

G

T

T

B

T

T

Template Predicted Secondary structure

89

90

.

.

.

.

.

.

.

.

.

100

.

.

.

.

.

.

.

.

.

110

.

.

.

.

.

.

.

.

.

120

.

.

.

.

.

.

.

.

.

130

.

.

.

.

.

.

.

.

.

140

.

.

.

.

Predicted Secondary structure

.

.

.

.

Query Sequence

F

G

Y

T

E

A

P

A

R

G

Q

Y

D

Y

T

F

A

N

L

T

K

T

I

E

R

F

T

D

Q

L

K

L

T

.

.

.

R

Y

A

M

A

V

H

D

Y

G

A

P

V

G

W

R

L

A

L

A

H

.

P

S

Query Conservation

.

.

.

.

Alig confidence

.

.

.

.

.

.

Template Conservation

.

.

Template Sequence

H

G

E

T

K

V

K

N

P

E

.

.

D

L

S

A

E

T

M

A

K

D

V

G

N

V

V

E

A

M

Y

G

D

L

P

P

P

I

M

L

I

G

H

S

M

G

G

A

I

A

V

H

T

A

S

S

N

L

V

P

Template Known Secondary structure

S

T

T

B

S

T

T

.

.

T

T

.

.

.

T

T

T

T

Template Predicted Secondary structure

.

.

145

.

.

.

.

150

.

.

.

.

.

.

.

.

.

160

.

.

.

.

.

.

.

.

.

170

.

.

.

.

.

.

.

.

.

180

.

.

.

.

.

.

.

.

.

190

.

.

.

.

.

.

.

.

.

200

.

.

.

.

Predicted Secondary structure

Query Sequence

R

I

T

A

I

I

S

Q

N

G

N

A

Y

E

E

G

L

S

A

G

W

E

P

I

R

K

Y

W

N

D

P

T

A

E

N

R

Q

A

L

S

D

F

P

T

P

A

S

I

K

W

Q

Y

V

E

G

V

S

D

T

S

Query Conservation

Alig confidence

.

.

.

.

.

.

.

.

Template Conservation

.

.

.

.

.

.

.

.

Template Sequence

S

L

L

G

L

C

M

I

D

V

V

E

G

T

A

M

D

A

L

N

S

M

Q

N

F

L

R

G

R

P

K

T

F

K

S

L

E

N

A

I

E

W

S

V

K

S

G

Q

I

R

N

L

.

.

.

.

.

.

.

.

Template Known Secondary structure

T

S

S

S

B

S

S

T

T

S

.

.

.

.

.

.

.

.

Template Predicted Secondary structure

.

.

.

.

.

.

.

.

205

.

.

.

.

210

.

.

.

.

.

.

.

.

.

220

.

.

.

.

.

.

.

.

.

230

.

.

.

.

.

.

.

.

.

240

.

.

.

.

.

.

.

.

.

250

.

.

.

.

.

.

.

.

.

260

.

.

.

.

Predicted Secondary structure

Query Sequence

L

V

A

P

D

A

Y

T

L

E

G

A

Q

I

L

R

P

G

M

A

D

I

Q

L

D

L

L

L

D

Y

A

T

N

V

E

Q

Y

P

A

F

Q

A

Y

F

R

E

Y

Q

P

P

L

L

A

V

W

G

E

H

D

P

Query Conservation

Alig confidence

.

.

.

Template Conservation

.

.

.

Template Sequence

.

.

.

E

S

A

R

V

S

M

V

G

Q

V

K

Q

C

E

P

Y

T

W

R

I

E

L

A

K

T

E

K

Y

W

D

G

W

F

R

G

L

S

N

L

F

L

S

C

P

I

P

K

L

L

L

L

A

G

V

D

R

Template Known Secondary structure

.

.

.

S

S

S

S

G

G

G

G

T

T

S

S

S

S

S

Template Predicted Secondary structure

.

.

.

265

.

.

.

.

270

.

.

.

.

.

.

.

.

.

280

.

.

.

.

.

.

.

.

.

290

.

.

.

.

.

.

.

.

.

300

.

.

.

.

.

.

.

.

.

310

.

Predicted Secondary structure

Query Sequence

F

F

L

P

P

G

A

E

A

W

K

R

D

I

P

D

A

D

I

R

L

Y

D

T

G

H

F

A

L

E

T

H

S

E

V

I

I

P

T

I

R

Q

F

L

D

D

H

Query Conservation

Alig confidence

.

.

Template Conservation

.

.

Template Sequence

L

D

K

D

L

T

I

G

Q

M

Q

G

K

F

.

.

Q

M

Q

V

L

P

Q

C

G

H

A

V

H

E

D

A

P

D

K

V

A

E

A

V

A

T

F

L

I

R

H

Template Known Secondary structure

T

T

S

.

.

S

S

S

T

Template Predicted Secondary structure

.

.

No model constructed - rank, confidence too low

---

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction
Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960
© Structural Bioinformatics Group, Imperial College, London Michael Sternberg   Disclaimer Terms and Conditions		Phyre2 is part of Genome3D