Job Description Undefined Confidence 99.81% Date Thu Nov 13 08:26:15 GMT 2025 Rank 347 Aligned Residues 247 % Identity 13% Template c2c7bA_ PDB info PDB header: hydrolase Chain: A: PDB Molecule: CARBOXYLESTERASE PDBTitle: the crystal structure of este1, a new thermophilic and thermostable carboxylesterase cloned from a metagenomic library PDB Entry: PDBe RCSB PDBj Resolution UNK

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		22	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.				.	.	.	.	.	.	.	60				.	.	.	.	.	.	.	.	.	70	.	.	.	.	.
Predicted Secondary structure																																	.	.	.									.	.	.
Query Sequence		G	R	A	S	A	A	P	Q	V	H	Y	R	V	E	Q	V	G	D	V	K	V	F	Y	R	E	A	G	D	P	A	A	.	.	.	P	A	V	L	L	L	H	G	.	.	.	F	A	A	S	S	Y	M	W	R	D	V	I	E	A	L
Query Conservation																																	.	.	.									.	.	.
Alig confidence																																	.	.	.									.	.	.
Template Conservation
Template Sequence		A	V	Q	E	P	I	A	E	T	R	D	V	H	I	P	V	S	G	G	S	I	R	A	R	V	Y	F	P	K	K	A	A	G	L	P	A	V	L	Y	Y	H	G	G	G	F	V	F	G	S	I	E	T	H	D	H	I	C	R	R	L
Template Known Secondary structure		S						S										T	T										S	S	S		S	S										S	T	T	T	S			T	G	G	G
Template Predicted Secondary structure
		76	.			.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.			.	.	.	.	.	.	.	.	130	.
Predicted Secondary structure				.	.																																													.	.
Query Sequence		A	D	.	.	G	Y	H	V	I	A	P	D	L	P	A	F	G	Y	T	E	A	P	A	R	G	Q	Y	D	Y	T	F	A	N	L	T	K	T	I	E	R	F	T	D	Q	L	K	L	T	.	.	R	Y	A	M	A	V	H	D	Y	G
Query Conservation				.	.																																													.	.
Alig confidence				.	.																			.	.	.																								.	.
Template Conservation																								.	.	.
Template Sequence		S	R	L	S	D	S	V	V	V	S	V	D	Y	R	L	A	P	E	Y	K	F	P	.	.	.	T	A	V	E	D	A	Y	A	A	L	K	W	V	A	D	R	A	D	E	L	G	V	D	P	D	R	I	A	V	A	G	D	S	A	G
Template Known Secondary structure						T								.	.	.	T	T	T	S		T	T	.	.	.																T					T												T
Template Predicted Secondary structure																								.	.	.
		132	.	.	.	.	.	.	.	140	.	.	.	.	.					.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.
Predicted Secondary structure																.	.	.	.
Query Sequence		A	P	V	G	W	R	L	A	L	A	H	P	S	R	.	.	.	.	I	T	A	I	I	S	Q	N	G	N	A	Y	E	E	G	L	S	A	G	W	E	P	I	R	K	Y	W	N	D	P	T	A	E	N	R	Q	A	L	S	D	F	P
Query Conservation																.	.	.	.
Alig confidence																.	.	.	.
Template Conservation
Template Sequence		G	N	L	A	A	V	V	S	I	L	D	R	N	S	G	E	K	L	V	K	K	Q	V	L	I	Y	P	V	V	N	T	G	V	P	T	A	S	L	V	E	F	G	V	A	E	T	T	S	L	P	I	E	L	V	W	F	G	R	Q	Y
Template Known Secondary structure															T	T					S						S					S	S													T	T		S	S		S			S
Template Predicted Secondary structure
		188	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.
Predicted Secondary structure
Query Sequence		T	P	A	S	I	K	W	Q	Y	V	E	G	V	S	D	T	S	L	V	A	P	D	A	Y	T	L	E	G	A	Q	I	L	R	P	G	M	A	D	I	Q	L	D	L	L	L	D	Y	A	T	N	V	E	Q	Y	P	A	F	Q	A	Y
Query Conservation
Alig confidence										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		L	K	R	P	E	E	A	Y	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	D	F	K	A	S	P	L	L	A	D
Template Known Secondary structure			S	S	T	T	G	G	G	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	S	T	T	T		G	G	G	S
Template Predicted Secondary structure										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
		248	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.		.	.	.	.	.	.	290	.	.	.	.						.	.	.	.	.	300	.
Predicted Secondary structure																																						.												.	.	.	.	.
Query Sequence		F	R	E	Y	Q	P	P	L	L	A	V	W	G	E	H	D	P	F	F	L	P	P	G	A	E	A	W	K	R	D	I	P	D	A	D	I	.	R	L	Y	D	T	G	H	F	A	L	E	.	.	.	.	.	T	H	S	E	V	I	I
Query Conservation																																						.												.	.	.	.	.
Alig confidence							.																															.												.	.	.	.	.
Template Conservation							.
Template Sequence		L	G	G	L	P	.	P	A	L	V	V	T	A	E	Y	D	P	L	R	D	E	G	E	L	Y	A	Y	K	K	A	S	G	S	R	A	V	A	V	R	F	A	G	V	H	G	F	V	S	F	Y	P	F	V	D	A	G	R	E	A	L
Template Known Secondary structure			T	T			.								T	T		T	T												T	T	S									S	S		T	T	G	G	G	G	T	T	T
Template Predicted Secondary structure							.
		302	.	.	.	.	.	.	.	310	.	.	.	.
Predicted Secondary structure
Query Sequence		P	T	I	R	Q	F	L	D	D	H	V	S	L
Query Conservation
Alig confidence
Template Conservation
Template Sequence		D	L	A	A	A	S	I	R	S	G	L	Q	P
Template Known Secondary structure												T
Template Predicted Secondary structure

No model constructed - rank, confidence too low

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Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960
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