Job Description Undefined Confidence 99.71% Date Thu Nov 13 08:26:15 GMT 2025 Rank 332 Aligned Residues 250 % Identity 13% Template c1qz3A_ PDB info PDB header: hydrolase Chain: A: PDB Molecule: CARBOXYLESTERASE EST2 PDBTitle: crystal structure of mutant m211s/r215l of carboxylesterase est2 complexed with hexadecanesulfonate PDB Entry: PDBe RCSB PDBj Resolution UNK

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		20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.					.	.	.	.	.	.	.	60	.	.				.	.	.	.	.	.	.	70	.	.
Predicted Secondary structure																																			.	.	.	.											.	.	.
Query Sequence		P	G	G	R	A	S	A	A	P	Q	V	H	Y	R	V	E	Q	V	G	D	V	K	V	F	Y	R	E	A	G	D	P	A	A	.	.	.	.	P	A	V	L	L	L	H	G	F	A	.	.	.	A	S	S	Y	M	W	R	D	V	I
Query Conservation																																			.	.	.	.											.	.	.
Alig confidence																																			.	.	.	.											.	.	.
Template Conservation
Template Sequence		P	P	V	K	K	E	P	V	A	E	V	R	E	F	D	M	D	L	P	G	R	T	L	K	V	R	M	Y	R	P	E	G	V	E	P	P	Y	P	A	L	V	Y	Y	H	G	G	G	W	V	V	G	D	L	E	T	H	D	P	V	C
Template Predicted Secondary structure
		73	.	.	.	.		.	.	80		.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.			.	.	.	120	.	.	.	.	.	.	.	.
Predicted Secondary structure							.				.																																					.	.
Query Sequence		E	A	L	A	D	.	G	Y	H	.	V	I	A	P	D	L	P	A	F	G	Y	T	E	A	P	A	R	G	Q	Y	D	Y	T	F	A	N	L	T	K	T	I	E	R	F	T	D	.	.	Q	L	K	L	T	R	Y	A	M	A	V	H
Query Conservation							.				.																																					.	.
Alig confidence							.				.													.	.	.																						.	.
Template Conservation																								.	.	.
Template Sequence		R	V	L	A	K	D	G	R	A	V	V	F	S	V	D	Y	R	L	A	P	E	H	.	.	.	K	F	P	A	A	V	E	D	A	Y	D	A	L	Q	W	I	A	E	R	A	A	D	F	H	L	D	P	A	R	I	A	V	G	G	D
Template Predicted Secondary structure																								.	.	.
		129	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.					.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.
Predicted Secondary structure																		.	.	.	.
Query Sequence		D	Y	G	A	P	V	G	W	R	L	A	L	A	H	P	S	.	.	.	.	R	I	T	A	I	I	S	Q	N	G	N	A	Y	E	E	G	L	S	A	G	W	E	P	I	R	K	Y	W	N	D	P	T	A	E	N	R	Q	A	L	S
Query Conservation																		.	.	.	.
Alig confidence																		.	.	.	.
Template Conservation
Template Sequence		S	A	G	G	N	L	A	A	V	T	S	I	L	A	K	E	R	G	G	P	A	L	A	F	Q	L	L	I	Y	P	S	T	G	Y	D	P	A	H	P	P	A	S	I	E	E	N	A	E	G	Y	L	L	T	G	G	M	S	L	W	F
Template Predicted Secondary structure
		185	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.
Predicted Secondary structure
Query Sequence		D	F	P	T	P	A	S	I	K	W	Q	Y	V	E	G	V	S	D	T	S	L	V	A	P	D	A	Y	T	L	E	G	A	Q	I	L	R	P	G	M	A	D	I	Q	L	D	L	L	L	D	Y	A	T	N	V	E	Q	Y	P	A	F
Query Conservation
Alig confidence																												.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																												.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		L	D	Q	Y	L	N	S	L	E	E	L	T	H	P	W	F	S	P	V	L	Y	P	D	L	S	G	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																												.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
		245	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270			.	.	.	.	.	.	.	.	.	280	.	.	.		.	.	.	.	.	.	290	.	.	.						.	.	.
Predicted Secondary structure																												.	.														.											.	.	.	.	.
Query Sequence		Q	A	Y	F	R	E	Y	Q	P	P	L	L	A	V	W	G	E	H	D	P	F	F	L	P	P	G	.	.	A	E	A	W	K	R	D	I	P	D	A	D	I	.	R	L	Y	D	T	G	H	F	A	L	.	.	.	.	.	E	T	H
Query Conservation																												.	.														.											.	.	.	.	.
Alig confidence		.	.	.	.	.	.	.																				.	.														.											.	.	.	.	.
Template Conservation		.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	L	P	P	A	Y	I	A	T	A	Q	Y	D	P	L	R	D	V	G	K	L	Y	A	E	A	L	N	K	A	G	V	K	V	E	I	E	N	F	E	D	L	I	H	G	F	A	Q	F	Y	S	L	S	P	G
Template Predicted Secondary structure		.	.	.	.	.	.	.
		297	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.
Predicted Secondary structure
Query Sequence		S	E	V	I	I	P	T	I	R	Q	F	L	D	D	H	V	S
Query Conservation
Alig confidence
Template Conservation
Template Sequence		A	T	K	A	L	V	R	I	A	E	K	L	R	D	A	L	A
Template Predicted Secondary structure

No model constructed - rank, confidence too low

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Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960
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