Job Description Q19726 Confidence 100.00% Date Sat Apr 13 13:19:58 BST 2013 Rank 5 Aligned Residues 386 % Identity 30% Template c2h8hA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor Resolution 2.20 Å Model Dimensions (Å) X:77.531 Y:70.317 Z:45.108

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		7	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.					.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.						70	.	.	.	.	.	.	.
Predicted Secondary structure																																										.	.	.	.																								.	.	.	.	.
Query SS confidence																																										.	.	.	.																								.	.	.	.	.
Query Sequence		A	T	D	S	S	S	S	T	S	S	M	T	E	N	S	D	G	Q	K	Q	N	N	E	W	F	H	G	V	L	Q	R	Q	D	A	D	E	L	L	V	K	.	.	.	.	P	G	S	F	L	L	R	A	S	E	V	H	G	K	M	S	M	I	L	S	V	R	H	.	.	.	.	.	D	G	K	L	H	N	I	A
Query Conservation																																										.	.	.	.																								.	.	.	.	.
Alig confidence																																										.	.	.	.													.											.	.	.	.	.
Template Conservation																																																										.
Template Sequence		S	T	G	Q	T	G	Y	I	P	S	N	Y	V	A	P	S	D	S	I	Q	A	E	E	W	Y	F	G	K	I	T	R	R	E	S	E	R	L	L	L	N	A	E	N	P	R	G	T	F	L	V	R	E	S	E	T	T	.	K	G	A	Y	C	L	S	V	S	D	F	D	N	A	K	G	L	N	V	K	H	Y	K
Template Known Secondary structure		T	T								G	G	G				T	T	S	G	G	G	S	T	T	B			S											T		T	T			T	T								S	S	S	.	T	T											T	T	T
Template Predicted Secondary structure																																																										.
Template SS confidence
		125	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.
		78	.	80	.		.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.							.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150
Predicted Secondary structure						.																																									.	.	.	.	.	.
Query SS confidence						.																																									.	.	.	.	.	.
Query Sequence		V	N	S	D	.	T	G	E	N	F	W	F	E	G	H	R	E	K	S	I	D	Q	L	V	Q	W	H	M	T	T	S	T	P	I	T	K	T	S	G	V	K	L	K	Y	P	.	.	.	.	.	.	I	G	K	A	D	W	I	I	S	H	E	N	V	I	F	I	K	K	L	G	E	G	A	F	G	E	V	S	L
Query Conservation						.																																									.	.	.	.	.	.
Alig confidence						.																																									.	.	.	.	.	.
Template Conservation
Template Sequence		I	R	K	L	D	S	G	G	F	Y	I	T	S	R	T	Q	F	N	S	L	Q	Q	L	V	A	Y	Y	S	K	H	A	D	G	L	C	H	R	L	T	T	V	C	P	T	S	K	P	Q	T	Q	G	L	A	K	D	A	W	E	I	P	R	E	S	L	R	L	E	V	K	L	G	Q	G	C	F	G	E	V	W	M
Template Known Secondary structure			B		.			S						T	T				S	S													T	T	S	S	S														S	S	S	S	T	T		S	B			G	G	G											S	S
Template Predicted Secondary structure
Template SS confidence
		204	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.
		151	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230
Predicted Secondary structure
Query SS confidence
Query Sequence		A	E	C	E	I	G	G	R	K	V	E	T	A	V	K	T	M	R	C	Q	M	T	R	D	T	R	A	A	F	M	K	E	A	R	L	M	R	K	Y	S	H	P	H	I	V	R	I	I	G	K	I	I	V	K	H	L	P	K	V	G	L	A	V	D	A	H	P	L	M	I	V	M	E	M	C	P	H	G	S	L
Query Conservation
Alig confidence									.	.	.													.	.																																.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation									.	.	.													.	.																																.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		G	T	W	N	G	T	T	.	.	.	R	V	A	I	K	T	L	K	P	G	T	M	.	.	S	P	E	A	F	L	Q	E	A	Q	V	M	K	K	L	R	H	E	K	L	V	Q	L	Y	A	V	V	S	E	E	P	.	.	.	.	.	.	.	.	.	.	.	.	I	Y	I	V	T	E	Y	M	S	K	G	S	L
Template Known Secondary structure					T	T	T		.	.	.									T	T	S	S	.	.																		T	T	B									S	S	S	.	.	.	.	.	.	.	.	.	.	.	.									T	T
Template Predicted Secondary structure									.	.	.													.	.																																.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		284	.	.	.	.	.	290				.	.	.	.	.	.	.	.	.	300	.	.			.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.													.	.	.	.	.	.	340	.	.	.	.	.	.
		231	.	.	.	.	.	.	.	.	240		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.		.	.	.	.
Predicted Secondary structure												.																																																																	.
Query SS confidence												.																																																																	.
Query Sequence		L	S	F	L	R	K	N	K	G	K	.	T	T	L	S	E	R	L	R	F	C	I	E	S	A	D	G	L	A	Y	L	E	K	K	Q	C	L	H	R	D	I	A	A	R	N	C	L	L	S	I	T	D	Q	I	K	I	S	D	F	G	L	S	D	D	K	R	T	E	M	H	D	D	T	L	D	.	K	V	P	V
Query Conservation												.																																																																	.
Alig confidence												.																																																																	.
Template Conservation
Template Sequence		L	D	F	L	K	G	E	T	G	K	Y	L	R	L	P	Q	L	V	D	M	A	A	Q	I	A	S	G	M	A	Y	V	E	R	M	N	Y	V	H	R	D	L	R	A	A	N	I	L	V	G	E	N	L	V	C	K	V	A	D	F	G	L	A	R	L	I	E	D	N	E	Y	T	A	R	Q	G	A	K	F	P	I
Template Known Secondary structure						S					T	T																							T	T				S			S	G	G	G					G	G	G							T	T	S	T	T	T								T	T		S	T	T	S		G
Template Predicted Secondary structure
Template SS confidence
		347	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.
		309	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		K	W	L	A	P	E	V	M	Q	D	K	L	Y	S	L	K	S	D	V	W	A	F	G	V	L	M	W	E	I	Y	A	D	G	A	D	P	Y	P	G	M	T	N	L	V	T	R	A	K	I	F	C	D	D	Y	R	M	T	F	P	E	T	T	P	P	T	I	S	E	I	A	L	K	Q	C	W	A	K	L	P	S
Query Conservation
Alig confidence																																																					.																		.
Template Conservation																																																					.																		.
Template Sequence		K	W	T	A	P	E	A	A	L	Y	G	R	F	T	I	K	S	D	V	W	S	F	G	I	L	L	T	E	L	T	T	K	G	R	V	P	Y	P	G	M	V	N	R	E	V	L	D	Q	V	E	R	.	G	Y	R	M	P	C	P	P	E	C	P	E	S	L	H	D	L	.	M	C	Q	C	W	R	K	E	P	E
Template Known Secondary structure		G	G	S																											T	T	T	T			S	S	T	T												T	.	T							T	T									.					T		S	S	G	G
Template Predicted Secondary structure																																																					.																		.
Template SS confidence
		427	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.		.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.		.	.	.	.	.	500	.	.	.	.
		389	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		D	R	A	T	M	K	T	V	H	H	K	L	K	D	L	S	M	P	M	S	D	V	S	F
Query Conservation
Alig confidence
Template Conservation
Template Sequence		E	R	P	T	F	E	Y	L	Q	A	F	L	E	D	Y	F	T	S	T	E	P	Q	Q	P
Template Known Secondary structure		G	S												T	S	S				S
Template Predicted Secondary structure
Template SS confidence
		505	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.