Email l.a.kelley@imperial.ac.uk Description O45498 Date Sat Apr 13 13:01:14 BST 2013 Unique Job ID d626f8bd288f10a0

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2c9wA_ 100.0 29 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 2 c2izvA_ 100.0 25 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 3 c2vifA_ 100.0 26 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 4 c3hizB_ 100.0 25 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 5 c2hmhA_ 99.9 22 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 6 d2izva2 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 7 d2c9wa2 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 8 c2eo6A_ 99.9 22 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 9 c2crhA_ 99.9 23 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 10 c2y3aB_ 99.9 25 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 11 c2dlzA_ 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 12 c1ka6A_ 99.9 22 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 13 d2oq1a1 99.9 18 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 14 d1r1qa_ 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 15 d1jwoa_ 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 16 d1fu6a_ 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 17 c2lctA_ 99.9 23 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 18 d1pica_ 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 19 d1d4ta_ 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 20 d2shpa2 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 21 c2ci8A_ not modelled 99.9 28 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 22 c2eo3A_ not modelled 99.9 21 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 23 c2oq1A_ not modelled 99.9 17 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 24 d1opka2 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 25 d3c7ia1 not modelled 99.9 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 26 c2fo0A_ not modelled 99.9 26 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 27 d1k9aa2 not modelled 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 28 c2lqnA_ not modelled 99.9 21 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 29 d1ayaa_ not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 30 d1a81e1 not modelled 99.9 16 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 31 c2ysxA_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 32 d2eyva1 not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 33 c2dlyA_ not modelled 99.9 27 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 34 c2kk6A_ not modelled 99.9 22 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 35 c2hdxB_ not modelled 99.9 24 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 36 d1qada_ not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 37 d1mila_ not modelled 99.9 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 38 c1k9aB_ not modelled 99.9 23 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 39 c2augB_ not modelled 99.9 19 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 40 d1a81a1 not modelled 99.9 15 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 41 d1i3za_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 42 d1fhsa_ not modelled 99.9 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 43 c2gsbA_ not modelled 99.9 15 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 44 d1a81e2 not modelled 99.9 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 45 c2eobA_ not modelled 99.9 28 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 46 d1nrva_ not modelled 99.9 16 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 47 c2ablA_ not modelled 99.9 28 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 48 d1rjaa_ not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 49 c1x6cA_ not modelled 99.9 27 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 50 c2el8A_ not modelled 99.9 15 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 51 d1jyra_ not modelled 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 52 c2shpA_ not modelled 99.9 25 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 53 c2b3oA_ not modelled 99.9 30 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 54 d2oq1a2 not modelled 99.9 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 55 c2ozoA_ not modelled 99.9 18 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 56 c1oplA_ not modelled 99.9 23 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 57 d2shpa3 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 58 d1luia_ not modelled 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 59 c3ps5A_ not modelled 99.9 25 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 60 d1g83a2 not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 61 d1blja_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 62 c3mazA_ not modelled 99.9 13 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 63 c2ge9A_ not modelled 99.9 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 64 c2dcrA_ not modelled 99.9 24 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 65 d1lkka_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 66 d2cs0a1 not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 67 c4fl2A_ not modelled 99.9 17 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 68 c2ekxA_ not modelled 99.9 26 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain 69 d1rpya_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 70 d1csya_ not modelled 99.9 18 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 71 c1y57A_ not modelled 99.9 20 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 72 c1rqqC_ not modelled 99.9 27 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 73 d1a81a2 not modelled 99.9 17 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 74 c2knoA_ not modelled 99.9 22 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 75 d2qmsa1 not modelled 99.9 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 76 d1o48a_ not modelled 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 77 d1xa6a2 not modelled 99.9 17 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 78 c1a81E_ not modelled 99.8 18 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 79 d1bkla_ not modelled 99.8 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 80 c3nhnA_ not modelled 99.8 28 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 81 c2h8hA_ not modelled 99.8 21 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 82 d1qcfa2 not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 83 d2fcia1 not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 d1f2fa_ not modelled 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 85 c1x27F_ not modelled 99.8 25 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 86 c3gqiB_ not modelled 99.8 21 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 87 c2c0iA_ not modelled 99.8 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 88 d1cwea_ not modelled 99.8 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 89 c2dm0A_ not modelled 99.8 20 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk 90 c1g83A_ not modelled 99.8 29 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 91 c2eyyA_ not modelled 99.8 19 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 92 c2eyzA_ not modelled 99.8 24 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 93 c2dvjA_ not modelled 99.8 22 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 94 c3gxxB_ not modelled 99.8 20 PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b 95 c2cr4A_ not modelled 99.8 20 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 96 c3qwyA_ not modelled 99.7 19 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 97 c3qwxX_ not modelled 99.7 19 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 98 c3or8A_ not modelled 99.7 23 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 99 c2dx0B_ not modelled 99.7 28 PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2 100 d1uura3 not modelled 99.6 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 101 c2xp1A_ not modelled 99.6 15 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 102 c1xa6A_ not modelled 99.6 19 PDB header:signaling protein Chain: A: PDB Molecule:beta2-chimaerin; PDBTitle: crystal structure of the human beta2-chimaerin 103 d2c9wa1 not modelled 99.5 36 Fold:SOCS box-like Superfamily:SOCS box-like Family:SOCS box-like 104 d1bf5a3 not modelled 99.5 14 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 105 d1bg1a3 not modelled 99.3 17 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 106 d2izva1 not modelled 99.2 23 Fold:SOCS box-like Superfamily:SOCS box-like Family:SOCS box-like 107 c3cblA_ not modelled 99.0 26 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: crystal structure of human feline sarcoma viral oncogene homologue (v-2 fes) in complex with staurosporine and a consensus peptide 108 c1uusA_ not modelled 98.5 18 PDB header:signal transduction Chain: A: PDB Molecule:stat protein; PDBTitle: structure of an activated dictyostelium stat in its2 dna-unbound form 109 c1yvlB_ not modelled 98.3 20 PDB header:signaling protein Chain: B: PDB Molecule:signal transducer and activator of transcription PDBTitle: structure of unphosphorylated stat1 110 c1y1uA_ not modelled 98.3 27 PDB header:signaling protein Chain: A: PDB Molecule:signal transducer and activator of transcription 5a; PDBTitle: structure of unphosphorylated stat5a 111 c2cblA_ not modelled 98.2 17 PDB header:complex (proto-oncogene/peptide) Chain: A: PDB Molecule:proto-oncogene cbl; PDBTitle: n-terminal domain of cbl in complex with its binding site2 on zap-70 112 c3bunB_ not modelled 98.2 17 PDB header:ligase/signaling protein Chain: B: PDB Molecule:e3 ubiquitin-protein ligase cbl; PDBTitle: crystal structure of c-cbl-tkb domain complexed with its2 binding motif in sprouty4 113 c1bf5A_ not modelled 98.2 22 PDB header:gene regulation/dna Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: tyrosine phosphorylated stat-1/dna complex 114 c1bg1A_ not modelled 98.0 26 PDB header:transcription/dna Chain: A: PDB Molecule:protein (transcription factor stat3b); PDBTitle: transcription factor stat3b/dna complex 115 c3cwgA_ not modelled 97.2 31 PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment 116 c1fbvA_ not modelled 92.6 19 PDB header:ligase Chain: A: PDB Molecule:signal transduction protein cbl; PDBTitle: structure of a cbl-ubch7 complex: ring domain function in2 ubiquitin-protein ligases 117 d3buxb3 not modelled 87.6 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 118 c3op0B_ not modelled 81.3 19 PDB header:signaling protein/signaling protein regu Chain: B: PDB Molecule:signal transduction protein cbl-c; PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide 119 c2jz3A_ not modelled 80.8 40 PDB header:transcription inhibitor/transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: socs box elonginbc ternary complex 120 c1griA_ not modelled 72.7 20 PDB header:signal transduction adaptor Chain: A: PDB Molecule:growth factor bound protein 2; PDBTitle: grb2