Job Description O45539 Confidence 100.00% Date Sat Apr 13 12:48:12 BST 2013 Rank 77 Aligned Residues 238 % Identity 24% Template c3vw6B_ PDB info PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:mitogen-activated protein kinase kinase kinase 5; PDBTitle: crystal structure of human apoptosis signal-regulating kinase 1 (ask1)2 with imidazopyridine inhibitor Resolution 2.40 Å

Show / Hide SS confidence

Show / Hide Conservation and Alignment quality

		232	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.		260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310
Predicted Secondary structure																														.
Query SS confidence																														.
Query Sequence		Q	W	E	V	D	R	R	S	V	R	L	I	R	Q	I	G	A	G	Q	F	G	E	V	W	E	G	R	W	.	N	V	N	V	P	V	A	V	K	K	L	K	A	G	T	A	D	P	T	D	F	L	A	E	A	Q	I	M	K	K	L	R	H	P	K	L	L	S	L	Y	A	V	C	T	R	D	E	P	I	L	I
Query Conservation																														.
Alig confidence																														.														.	.	.	.	.
Template Conservation																																												.	.	.	.	.
Template Sequence		E	Y	D	Y	E	Y	D	E	N	G	D	R	V	V	L	G	K	G	T	Y	G	I	V	Y	A	G	R	D	L	S	N	Q	V	R	I	A	I	K	E	I	P	E	.	.	.	.	.	Q	P	L	H	E	E	I	A	L	H	K	H	L	K	H	K	N	I	V	Q	Y	L	G	S	F	S	E	N	G	F	I	K	I
Template Known Secondary structure							B		T	T	S	S	B							S	S	S								T	T	T												.	.	.	.	.											T	T				T	T	B										T	T
Template Predicted Secondary structure																																												.	.	.	.	.
Template SS confidence
		672	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.						.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.
		311	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.				.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.		.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.
Predicted Secondary structure																				.	.	.																																							.
Query SS confidence																				.	.	.																																							.
Query Sequence		V	T	E	L	M	Q	E	N	L	L	T	F	L	Q	R	R	G	R	.	.	.	Q	C	Q	M	P	Q	L	V	E	I	S	A	Q	V	A	A	G	M	A	Y	L	E	E	M	N	F	I	H	R	D	L	A	A	R	N	I	L	I	.	N	N	S	L	S	V	K	I	A	D	F	G	L	A	R	I	L	M	K	E
Query Conservation																				.	.	.																																							.
Alig confidence																				.	.	.																																							.																			.	.
Template Conservation																																																																																.	.
Template Sequence		F	M	E	Q	V	P	G	G	S	L	S	A	L	L	R	S	K	W	G	P	L	K	D	N	E	Q	T	I	G	F	Y	T	K	Q	I	L	E	G	L	K	Y	L	H	D	N	Q	I	V	H	R	D	I	K	G	D	N	V	L	I	N	T	Y	S	G	V	L	K	I	S	D	F	G	T	S	K	R	L	T	.	.
Template Known Secondary structure							T	T		B								T	T				T	T																						T	T				S			S	G	G	G					T	T	T									S	S						.	.
Template Predicted Secondary structure																																																																																.	.
Template SS confidence
		753	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830
		387	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.			.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.			.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.
Predicted Secondary structure																											.	.																																	.	.
Query SS confidence																											.	.																																	.	.
Query Sequence		N	E	Y	E	A	R	T	G	A	R	F	P	I	K	W	T	A	P	E	A	A	N	Y	N	R	.	.	F	T	T	K	S	D	V	W	S	F	G	I	L	L	T	E	I	V	T	F	G	R	L	P	Y	P	G	M	T	N	A	E	.	.	V	L	Q	Q	V	D	A	G	Y	R	M	P	C	P	A	G	C	P	V
Query Conservation																											.	.																																	.	.
Alig confidence		.	.	.	.	.	.	.	.	.	.																.	.																				.													.	.
Template Conservation		.	.	.	.	.	.	.	.	.	.																																					.
Template Sequence		.	.	.	.	.	.	.	.	.	.	G	T	L	Q	Y	M	A	P	E	I	I	D	K	G	P	R	G	Y	G	K	A	A	D	I	W	S	L	G	C	T	I	I	E	M	A	T	.	G	K	P	P	F	Y	E	L	G	E	P	Q	A	A	M	F	K	V	G	M	F	K	V	H	P	E	I	P	E	S	M	S	A
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	.			G	G	G										G	G	G		S																		.	S	S		T	T	G	G	G		S												T							T	T	S
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.																																					.
Template SS confidence
												841	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.		.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.
		463	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		T	L	Y	D	I	M	Q	Q	C	W	R	S	D	P	D	K	R	P	T	F	E	T	L	Q	W
Query Conservation
Alig confidence
Template Conservation
Template Sequence		E	A	K	A	F	I	L	K	C	F	E	P	D	P	D	K	R	A	C	A	N	D	L	L	V
Template Known Secondary structure											T		S		T	T	T	S								T
Template Predicted Secondary structure
Template SS confidence
		910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.

No model constructed - rank, confidence too low

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D