Job Description O45539 Confidence 100.00% Date Sat Apr 13 12:48:12 BST 2013 Rank 1 Aligned Residues 456 % Identity 39% Template c2fo0A_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase Resolution 2.27 Å Model Dimensions (Å) X:71.029 Y:76.464 Z:49.608

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		46	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	G	N	T	I	D	K	N	Q	N	I	S	Q	S	A	N	F	V	A	L	F	Q	Y	D	A	R	T	D	D	D	L	S	F	K	K	D	D	I	L	E	I	L	N	D	T	Q	G	D	W	W	F	A	R	H	K	A	T	G	R	T	G	Y	I	P	S	N	Y	V	A	R	E	K	S	I	E	S	Q	P	W	Y
Query Conservation
Alig confidence																																																									.
Template Conservation																																																									.
Template Sequence		N	K	E	N	L	L	A	G	P	S	E	N	D	P	N	L	F	V	A	L	Y	D	F	V	A	S	G	D	N	T	L	S	I	T	K	G	E	K	L	R	V	L	G	Y	N	H	N	G	E	W	C	E	A	Q	T	.	K	N	G	Q	G	W	V	P	S	N	Y	I	T	P	V	N	S	L	E	K	H	S	W	Y
Template Known Secondary structure				T	T	T	T			G	G	G	S		T	T					S	S		B				S	T	T	B			B		T	T										T	T	S	S							.	T	T							G	G	G				T	T	S	G	G	G	S	T	T
Template Predicted Secondary structure																																																									.
Template SS confidence
		68	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.		.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.
		126	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	G	K	M	R	R	I	D	A	E	K	C	L	L	H	T	L	N	E	H	G	A	F	L	V	R	D	S	E	S	R	Q	H	D	L	S	L	S	V	R	E	N	D	S	V	K	H	Y	R	I	R	Q	L	D	H	G	G	Y	F	I	A	R	R	R	P	F	A	T	L	H	D	L	I	A	H	Y	Q	R	E	A
Query Conservation
Alig confidence															.	.
Template Conservation															.	.
Template Sequence		H	G	P	V	S	R	N	A	A	E	Y	L	L	.	.	S	S	G	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	Q	R	S	I	S	L	R	Y	E	G	R	V	Y	H	Y	R	I	N	T	A	S	D	G	K	L	Y	V	S	S	E	S	R	F	N	T	L	A	E	L	V	H	H	H	S	T	V	A
Template Known Secondary structure														T	.	.	S	S	S		T	T								S	S	S	T	T									T	T											T	T	S				S	S	T	T			B	S	S
Template Predicted Secondary structure															.	.
Template SS confidence
		148	.	150	.	.	.	.	.	.	.	.	.	160			.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.
		206	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.		230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.		.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.
Predicted Secondary structure																										.																																	.
Query SS confidence																										.																																	.
Query Sequence		D	G	L	C	V	N	L	G	A	P	C	A	K	S	E	A	P	Q	T	T	T	F	T	Y	.	D	D	Q	W	E	V	D	R	R	S	V	R	L	I	R	Q	I	G	A	G	Q	F	G	E	V	W	E	G	R	W	N	V	.	N	V	P	V	A	V	K	K	L	K	A	G	T	A	D	P	T	D	F	L	A	E
Query Conservation																										.																																	.
Alig confidence																										.																																	.
Template Conservation
Template Sequence		D	G	L	I	T	T	L	H	Y	P	A	P	K	R	N	K	P	T	V	Y	G	V	S	P	N	Y	D	K	W	E	M	E	R	T	D	I	T	M	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	E	G	V	W	K	K	Y	S	L	T	V	A	V	K	T	L	K	E	D	T	M	E	V	E	E	F	L	K	E
Template Known Secondary structure		T	T	S	S	S															S	S	S		S	S	T	T			B			G	G	G							S	G	G	G	T	T	S	S							G	G	G	T										T	T	S
Template Predicted Secondary structure
Template SS confidence
		226	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.
		284	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.			.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.
Predicted Secondary structure																																													.	.
Query SS confidence																																													.	.
Query Sequence		A	Q	I	M	K	K	L	R	H	P	K	L	L	S	L	Y	A	V	C	T	R	D	E	P	I	L	I	V	T	E	L	M	Q	E	N	L	L	T	F	L	Q	R	R	.	.	G	R	Q	C	Q	M	P	Q	L	V	E	I	S	A	Q	V	A	A	G	M	A	Y	L	E	E	M	N	F	I	H	R	D	L	A	A
Query Conservation																																													.	.
Alig confidence																																													.	.
Template Conservation
Template Sequence		A	A	V	M	K	E	I	K	H	P	N	L	V	Q	L	L	G	V	C	T	R	E	P	P	F	Y	I	I	T	E	F	M	T	Y	G	N	L	L	D	Y	L	R	E	C	N	R	Q	E	V	N	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A	M	E	Y	L	E	K	K	N	F	I	H	R	N	L	A	A
Template Known Secondary structure											T	T	B									S	S	S	S									T	T		B								S		T	T	T	S																						T	T				S			S	G
Template Predicted Secondary structure
Template SS confidence
		306	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.
		362	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	N	I	L	I	N	N	S	L	S	V	K	I	A	D	F	G	L	A	R	I	L	M	K	E	N	E	Y	E	A	R	T	G	A	R	F	P	I	K	W	T	A	P	E	A	A	N	Y	N	R	F	T	T	K	S	D	V	W	S	F	G	I	L	L	T	E	I	V	T	F	G	R	L	P	Y	P	G	M	T	N
Query Conservation
Alig confidence																								.
Template Conservation																								.
Template Sequence		R	N	C	L	V	G	E	N	H	L	V	K	V	A	D	F	G	L	S	R	L	M	.	T	G	D	T	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S	L	A	Y	N	K	F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I	D	L
Template Known Secondary structure		G	G					G	G	G							T	T						.	S	S							T	T					G	G	G																													T	T	S			S	S	T	T
Template Predicted Secondary structure																								.
Template SS confidence
		386	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.		.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.
		442	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.		.	.	500	.	.	.	.	.
Predicted Secondary structure																																																										.
Query SS confidence																																																										.
Query Sequence		A	E	V	L	Q	Q	V	D	A	G	Y	R	M	P	C	P	A	G	C	P	V	T	L	Y	D	I	M	Q	Q	C	W	R	S	D	P	D	K	R	P	T	F	E	T	L	Q	W	K	L	E	D	L	F	N	L	D	S	.	S	E	Y	K	E	A	S	I
Query Conservation																																																										.
Alig confidence																																																										.
Template Conservation
Template Sequence		S	Q	V	Y	E	L	L	E	K	D	Y	R	M	E	R	P	E	G	C	P	E	K	V	Y	E	L	M	R	A	C	W	Q	W	N	P	S	D	R	P	S	F	A	E	I	H	Q	A	F	E	T	M	F	Q	E	S	S	I	S	D	E	V	E	K	E	L
Template Known Secondary structure										T	T							T	T													T		S	S	G	G	G	S												T	S	S	S	S	S
Template Predicted Secondary structure
Template SS confidence
		465	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.