Job Description O01325 Confidence 100.00% Date Fri May 3 21:21:05 BST 2013 Rank 4 Aligned Residues 424 % Identity 29% Template c2h8hA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor Resolution 2.20 Å Model Dimensions (Å) X:74.666 Y:69.658 Z:52.080

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		26	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	L	L	K	A	T	D	E	T	S	S	D	G	A	S	T	S	L	S	K	S	V	E	E	S	A	P	N	K	D	K	S	N	S	S	L	V	K	S	H	H	V	L	K	I	K	L	K	K	I	T	N	W	S	G	C	S	G	A	L	L	D	D	E	P	F	Y	H	G	Y	M	S	R	E	E	S	E	K	L	V
Query Conservation
Alig confidence																																																											.	.
Template Conservation																																																											.	.
Template Sequence		T	F	V	A	L	Y	D	Y	E	S	R	T	E	T	D	L	S	F	K	K	G	E	R	L	Q	I	V	N	N	T	E	G	D	W	W	L	A	H	S	L	S	T	G	Q	T	G	Y	I	P	S	N	Y	V	A	P	S	D	.	.	S	I	Q	A	E	E	W	Y	F	G	K	I	T	R	R	E	S	E	R	L	L
Template Known Secondary structure						S	S		B				S	S	S	B			B		T	T									S	S	S	S							T	T	T								G	G	G				T	T	.	.	S	G	G	G	S	T	T	B			S
Template Predicted Secondary structure																																																											.	.
Template SS confidence
		85	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.			.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.
		106	.					.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.				.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150		.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.
Predicted Secondary structure				.	.	.	.																											.	.	.																		.																							.	.	.	.	.
Query SS confidence				.	.	.	.																											.	.	.																		.																							.	.	.	.	.
Query Sequence		R	S	.	.	.	.	Q	G	E	F	L	L	R	K	T	E	L	T	K	R	G	E	V	V	V	L	S	V	F	W	D	E	.	.	.	G	V	H	H	L	V	V	E	K	A	N	N	G	L	Y	Y	L	.	K	E	F	C	F	E	N	I	S	D	L	V	R	Y	H	H	Q	T	R	A	S	V	.	.	.	.	.
Query Conservation				.	.	.	.																											.	.	.																		.																							.	.	.	.	.
Alig confidence				.	.	.	.																											.	.	.																		.																							.	.	.	.	.
Template Conservation
Template Sequence		L	N	A	E	N	P	R	G	T	F	L	V	R	E	S	E	T	T	K	G	A	Y	C	L	S	V	S	D	F	D	N	A	K	G	L	N	V	K	H	Y	K	I	R	K	L	D	S	G	G	F	Y	I	T	S	R	T	Q	F	N	S	L	Q	Q	L	V	A	Y	Y	S	K	H	A	D	G	L	C	H	R	L	T
Template Known Secondary structure		T		T	T			T	T								S	S	S	T	T											T	T	T										B		.			S						T	T				S	S													T	T	S	S	S
Template Predicted Secondary structure
Template SS confidence
		163	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.
				173	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250
Predicted Secondary structure		.	.
Query SS confidence		.	.
Query Sequence		.	.	Y	K	S	G	I	K	L	F	S	W	V	V	R	E	E	W	Q	L	Y	H	E	Q	I	N	L	G	K	K	L	G	N	G	E	F	G	E	V	F	Q	G	V	L	S	V	G	I	F	T	N	D	V	E	V	A	V	K	T	M	K	G	S	K	V	T	A	D	E	R	I	T	F	L	R	E	A	N	L	M
Query Conservation		.	.
Alig confidence		.	.																																												.	.	.	.	.																				.	.	.
Template Conservation																																															.	.	.	.	.																				.	.	.
Template Sequence		T	V	C	P	T	S	K	P	Q	T	Q	G	L	A	K	D	A	W	E	I	P	R	E	S	L	R	L	E	V	K	L	G	Q	G	C	F	G	E	V	W	M	G	T	W	N	.	.	.	.	.	G	T	T	R	V	A	I	K	T	L	K	P	G	T	M	S	P	E	A	.	.	.	F	L	Q	E	A	Q	V	M
Template Known Secondary structure												S	S	S	S	T	T		S	B			G	G	G											S	S									T	.	.	.	.	.	T	T										T	T	S	S					.	.	.
Template Predicted Secondary structure																																															.	.	.	.	.																				.	.	.
Template SS confidence
		243	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.						.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.				.	.	.	310	.	.	.	.
		251	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.		.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																																							.
Query SS confidence																																							.
Query Sequence		L	K	L	N	H	K	Y	V	V	R	L	Y	G	V	A	T	Q	Q	E	P	I	M	I	V	M	E	L	C	S	G	G	C	L	K	S	R	I	.	E	K	K	D	E	Q	L	S	D	V	L	K	R	K	Y	C	K	Q	I	A	K	G	M	R	Y	L	E	K	K	Q	V	I	H	R	D	L	A	A	R	N	V	L
Query Conservation																																							.
Alig confidence																		.																					.
Template Conservation																		.
Template Sequence		K	K	L	R	H	E	K	L	V	Q	L	Y	A	V	V	S	.	E	E	P	I	Y	I	V	T	E	Y	M	S	K	G	S	L	L	D	F	L	K	G	E	T	G	K	Y	L	R	L	P	Q	L	V	D	M	A	A	Q	I	A	S	G	M	A	Y	V	E	R	M	N	Y	V	H	R	D	L	R	A	A	N	I	L
Template Known Secondary structure							T	T	B									.	S	S	S									T	T								S					T	T																							T	T				S			S	G	G	G
Template Predicted Secondary structure																		.
Template SS confidence
		315	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330		.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.
		330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.			.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.		.	.	.	.	.	.	.	.	400	.	.	.	.	.	.
Predicted Secondary structure																			.	.																																														.
Query SS confidence																			.	.																																														.
Query Sequence		L	D	K	S	D	N	C	K	I	S	D	F	G	L	S	L	F	.	.	G	K	L	H	K	E	Q	K	L	M	K	V	P	I	R	W	L	A	P	E	T	L	L	K	G	I	Y	S	S	K	S	D	V	W	S	F	G	V	V	M	F	E	V	F	S	.	G	E	Y	P	Y	A	D	V	K	V	L	K	E	L	R
Query Conservation																			.	.																																														.
Alig confidence																			.	.																																														.										.
Template Conservation																																																																												.
Template Sequence		V	G	E	N	L	V	C	K	V	A	D	F	G	L	A	R	L	I	E	D	N	E	Y	T	A	R	Q	G	A	K	F	P	I	K	W	T	A	P	E	A	A	L	Y	G	R	F	T	I	K	S	D	V	W	S	F	G	I	L	L	T	E	L	T	T	K	G	R	V	P	Y	P	G	M	V	.	N	R	E	V	L
Template Known Secondary structure				G	G	G							T	T	S	T	T	T								T	T		S	T	T	S		G	G	G	S																											T	T	T	T			S	S	T	T			.
Template Predicted Secondary structure																																																																												.
Template SS confidence
		394	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.		.	.	470	.	.
		407	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	K	V	A	H	E	N	L	R	L	K	P	P	S	D	M	P	T	D	D	A	K	V	M	E	M	C	F	E	P	V	D	N	R	A	T	F	V	Q	V	C	N	R	Y	K	D	L	T	S	P	L	P	T	W	N
Query Conservation
Alig confidence
Template Conservation
Template Sequence		D	Q	V	E	R	G	Y	R	M	P	C	P	P	E	C	P	E	S	L	H	D	L	M	C	Q	C	W	R	K	E	P	E	E	R	P	T	F	E	Y	L	Q	A	F	L	E	D	Y	F	T	S	T	E	P	Q	Q
Template Known Secondary structure						T	T							T	T													T		S	S	G	G	G	S												T	S	S				S
Template Predicted Secondary structure
Template SS confidence
		473	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.