Job Description O01325 Confidence 100.00% Date Fri May 3 21:21:05 BST 2013 Rank 2 Aligned Residues 433 % Identity 27% Template c1oplA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase Resolution 3.42 Å Model Dimensions (Å) X:77.783 Y:69.157 Z:49.536

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		23	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	P	D	L	L	L	K	A	T	D	E	T	S	S	D	G	A	S	T	S	L	S	K	S	V	E	E	S	A	P	N	K	D	K	S	N	S	S	L	V	K	S	H	H	V	L	K	I	K	L	K	K	I	T	N	W	S	G	C	S	G	A	L	L	D	D	E	P	F	Y	H	G	Y	M	S	R	E	E	S	E
Query Conservation
Alig confidence																																													.																	.	.
Template Conservation																																													.																	.	.
Template Sequence		D	P	N	L	F	V	A	L	Y	D	F	V	A	S	G	D	N	T	L	S	I	T	K	G	E	K	L	R	V	L	G	Y	N	H	N	G	E	W	C	E	A	Q	T	.	K	N	G	Q	G	W	V	P	S	N	Y	I	T	P	V	N	.	.	S	L	E	K	H	S	W	Y	H	G	P	V	S	R	N	A	A	E
Template Known Secondary structure			T	T					S	S		B				S	T	T	B			B		T	T										T	T	S	S							.	S	S							G	G	G				S	S	.	.	S	G	G	G	S	T	T
Template Predicted Secondary structure																																													.																	.	.
Template SS confidence
		81	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.		.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.			140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.
		103	.	.	.			.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150		.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.
Predicted Secondary structure						.	.																																													.																							.	.	.	.	.	.	.
Query SS confidence						.	.																																													.																							.	.	.	.	.	.	.
Query Sequence		K	L	V	R	.	.	S	Q	G	E	F	L	L	R	K	T	E	L	T	K	R	G	E	V	V	V	L	S	V	F	W	D	E	G	V	H	H	L	V	V	E	K	A	N	N	G	L	Y	Y	L	.	K	E	F	C	F	E	N	I	S	D	L	V	R	Y	H	H	Q	T	R	A	S	V	.	.	.	.	.	.	.
Query Conservation						.	.																																													.																							.	.	.	.	.	.	.
Alig confidence						.	.																.	.																												.																							.	.	.	.	.	.	.
Template Conservation																							.	.
Template Sequence		Y	L	L	S	S	G	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	.	.	Q	R	S	I	S	L	R	Y	E	G	R	V	Y	H	Y	R	I	N	T	A	S	D	G	K	L	Y	V	S	S	E	S	R	F	N	T	L	A	E	L	V	H	H	H	S	T	V	A	D	G	L	I	T	T	L	H	Y	P
Template Known Secondary structure				G	G	G			T	T								S	S	S	T	T	.	.									T	T											T	T	S				S	S	T	T	S		B	S	S									T	T			T	T	S	S	S
Template Predicted Secondary structure																							.	.
Template SS confidence
		158	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.			.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.
					173	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.
Predicted Secondary structure		.	.	.
Query SS confidence		.	.	.
Query Sequence		.	.	.	Y	K	S	G	I	K	L	F	S	W	V	V	R	E	E	W	Q	L	Y	H	E	Q	I	N	L	G	K	K	L	G	N	G	E	F	G	E	V	F	Q	G	V	L	S	V	G	I	F	T	N	D	V	E	V	A	V	K	T	M	K	G	S	K	V	T	A	D	E	R	I	T	F	L	R	E	A	N	L
Query Conservation		.	.	.
Alig confidence		.	.	.																																												.	.	.	.																					.	.	.
Template Conservation																																																.	.	.	.																					.	.	.
Template Sequence		A	P	K	R	N	K	P	T	V	Y	G	V	S	P	N	Y	D	K	W	E	M	E	R	T	D	I	T	M	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	E	G	V	W	K	.	.	.	.	K	Y	S	L	T	V	A	V	K	T	L	K	E	D	T	M	E	V	E	E	.	.	.	F	L	K	E	A	A	V
Template Known Secondary structure						S					S	S	S		S	S	S	S			B			G	G	G							S	G	G	G	T	T	S	S							G	.	.	.	.	G	G	T										S	S	S	S					.	.	.
Template Predicted Secondary structure																																																.	.	.	.																					.	.	.
Template SS confidence
		236	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.					.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.				.	.	.	.	.	.	.
		250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.		.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.
Predicted Secondary structure																																													.
Query SS confidence																																													.
Query Sequence		M	L	K	L	N	H	K	Y	V	V	R	L	Y	G	V	A	T	Q	Q	E	P	I	M	I	V	M	E	L	C	S	G	G	C	L	K	S	R	I	E	K	K	D	E	.	Q	L	S	D	V	L	K	R	K	Y	C	K	Q	I	A	K	G	M	R	Y	L	E	K	K	Q	V	I	H	R	D	L	A	A	R	N	V
Query Conservation																																													.
Alig confidence																																													.
Template Conservation
Template Sequence		M	K	E	I	K	H	P	N	L	V	Q	L	L	G	V	C	T	R	E	P	P	F	Y	I	I	T	E	F	M	T	Y	G	N	L	L	D	Y	L	R	E	C	N	R	Q	E	V	N	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A	M	E	Y	L	E	K	K	N	F	I	H	R	N	L	A	A	R	N	C
Template Known Secondary structure								T	T	B									S	S	S	S									T	T		B								S		T	T	T	S																						T	T				S			S	G	G	G
Template Predicted Secondary structure
Template SS confidence
		309	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.
		329	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.			.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.		.	.	.	.	.	.	.	.	400	.	.	.	.	.
Predicted Secondary structure																				.	.																																														.
Query SS confidence																				.	.																																														.
Query Sequence		L	L	D	K	S	D	N	C	K	I	S	D	F	G	L	S	L	F	.	.	G	K	L	H	K	E	Q	K	L	M	K	V	P	I	R	W	L	A	P	E	T	L	L	K	G	I	Y	S	S	K	S	D	V	W	S	F	G	V	V	M	F	E	V	F	S	.	G	E	Y	P	Y	A	D	V	K	V	L	K	E	L
Query Conservation																				.	.																																														.
Alig confidence																				.	.																																														.										.
Template Conservation																																																																													.
Template Sequence		L	V	G	E	N	H	L	V	K	V	A	D	F	G	L	S	R	L	M	T	G	D	T	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S	L	A	Y	N	K	F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I	D	.	L	S	Q	V
Template Known Secondary structure					G	G	G							T	T						T	T							T	T					G	G	G																													T	T	S			S	S	T	T			.	T	T	T
Template Predicted Secondary structure																																																																													.
Template SS confidence
		389	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.		.	.	.	.
		406	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	R	K	V	A	H	E	N	L	R	L	K	P	P	S	D	M	P	T	D	D	A	K	V	M	E	M	C	F	E	P	V	D	N	R	A	T	F	V	Q	V	C	N	R	Y	K	D	L	T	S	P	L	P	T	W	N	G	I	A	N	K	L	I
Query Conservation
Alig confidence
Template Conservation
Template Sequence		Y	E	L	L	E	K	D	Y	R	M	E	R	P	E	G	C	P	E	K	V	Y	E	L	M	R	A	C	W	Q	W	N	P	S	D	R	P	S	F	A	E	I	H	Q	A	F	E	T	M	F	Q	E	S	S	I	S	D	E	V	E	K	E	L	G
Template Known Secondary structure							T	T							T	T													T		S	S	G	G	G	S												T	S		S	S	S
Template Predicted Secondary structure
Template SS confidence
		468	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530