Job Description Q22146 Confidence 100.00% Date Sat Apr 13 13:24:31 BST 2013 Rank 7 Aligned Residues 365 % Identity 29% Template c4fl2A_ PDB info PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch Resolution 2.19 Å Model Dimensions (Å) X:71.577 Y:85.993 Z:49.270

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		16	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.					.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.
Predicted Secondary structure																									.	.	.	.
Query SS confidence																									.	.	.	.
Query Sequence		D	D	I	R	S	A	E	Y	Y	H	G	M	V	P	R	Q	D	A	E	G	F	L	K	.	.	.	.	R	E	G	D	F	L	V	R	K	T	E	Q	M	P	G	K	V	V	L	A	M	S	V	R	V	T	D	E	L	C	R	H	F	M	L	N	M	D	P	T	S	N	K	F	Y	F	E	H	T	H	Q	E	S
Query Conservation																									.	.	.	.
Alig confidence																									.	.	.	.												.										.	.	.																.
Template Conservation																																								.										.	.	.																.
Template Sequence		T	A	H	E	K	M	P	W	F	H	G	K	I	S	R	E	E	S	E	Q	I	V	L	I	G	S	K	T	N	G	K	F	L	I	R	A	R	D	.	N	N	G	S	Y	A	L	C	L	.	.	.	L	H	E	G	K	V	L	H	Y	R	I	D	K	D	K	.	T	G	K	L	S	I	P	E	G	K	K	F	D
Template Known Secondary structure		S		G	G	G	S	T	T	B			S												S	S	S			T	T									.	T	T	T							.	.	.			T	T											T	.	T	S				S	T	T				B	S
Template Predicted Secondary structure																																								.										.	.	.																.
Template SS confidence
		161	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.		.	200	.	.	.	.	.	.	.				.	.	210	.	.	.	.	.	.	.	.	.	220	.	.		.	.	.	.	.	.	.	230	.	.	.	.	.
		92	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.																	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.									.	.	.	140	.	.	.	.	.	.	.
Predicted Secondary structure																				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																												.	.	.	.	.	.	.	.
Query SS confidence																				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																												.	.	.	.	.	.	.	.
Query Sequence		T	I	S	E	L	I	N	W	H	M	T	T	K	T	P	I	S	A	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	A	S	G	A	K	I	R	R	P	M	E	R	S	P	W	L	I	N	H	D	S	I	V	A	N	K	K	.	.	.	.	.	.	.	.	L	G	E	G	A	F	G	D	V	F	I
Query Conservation																				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																												.	.	.	.	.	.	.	.
Alig confidence																				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																												.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		T	L	W	Q	L	V	E	H	Y	S	Y	K	A	D	G	L	L	R	V	L	T	V	P	C	Q	K	I	G	T	Q	R	E	A	L	P	M	D	T	E	V	Y	E	S	P	Y	A	D	P	E	E	I	R	P	K	E	V	Y	L	D	R	K	L	L	T	L	E	D	K	E	L	G	S	G	N	F	G	T	V	K	K
Template Known Secondary structure		S									T	T	B		T	T	S	S	S				S	B				S				T	T			G	G	G	S	G	G	G	S		G	G	G	S	T	T	S				S	S	S	B			G	G	G												T	T
Template Predicted Secondary structure
Template SS confidence
		236	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.
		148	.	150		.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.		.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.		220	.	.	.	.
Predicted Secondary structure					.																			.																																																				.
Query SS confidence					.																			.																																																				.
Query Sequence		A	E	L	.	D	Q	G	G	K	Q	E	V	A	V	K	T	M	R	A	E	A	T	.	R	E	A	R	L	R	F	M	K	E	A	R	L	M	R	K	Y	Q	H	K	H	V	V	K	L	I	G	V	A	I	H	E	H	P	L	M	I	V	M	E	Y	C	P	N	G	S	L	L	S	H	L	.	K	K	N	K	V
Query Conservation					.																			.																																																				.
Alig confidence					.																			.																																		.																		.
Template Conservation																																																										.
Template Sequence		G	Y	Y	Q	M	K	K	V	V	K	T	V	A	V	K	I	L	K	N	E	A	N	D	P	A	L	K	D	E	L	L	A	E	A	N	V	M	Q	Q	L	D	N	P	Y	I	V	R	M	I	G	I	C	E	A	E	S	.	W	M	L	V	M	E	M	A	E	L	G	P	L	N	K	Y	L	Q	Q	N	R	H	V
Template Known Secondary structure							T	T												S	G	G	G		G	G	G																	T	T	B									S	S	S	.									T	T		B									T	T	S
Template Predicted Secondary structure																																																										.
Template SS confidence
		388	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.		.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.
		225	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.					280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Predicted Secondary structure																																																									.	.	.	.
Query SS confidence																																																									.	.	.	.
Query Sequence		S	L	I	E	K	L	R	F	T	T	E	A	A	D	G	I	A	Y	L	E	R	S	K	C	I	H	R	D	I	A	A	R	N	C	L	L	S	A	K	N	E	L	K	I	S	D	F	G	M	S	D	N	K	D	E	.	.	.	.	I	K	D	E	T	L	E	K	V	P	I	K	W	L	A	P	E	T	M	Q	E
Query Conservation																																																									.	.	.	.
Alig confidence																																																									.	.	.	.
Template Conservation
Template Sequence		K	D	K	N	I	I	E	L	V	H	Q	V	S	M	G	M	K	Y	L	E	E	S	N	F	V	H	R	D	L	A	A	R	N	V	L	L	V	T	Q	H	Y	A	K	I	S	D	F	G	L	S	K	A	L	R	A	D	E	N	Y	Y	K	A	Q	T	H	G	K	W	P	V	K	W	Y	A	P	E	C	I	N	Y
Template Known Secondary structure																							T	T				S			S	G	G	G						T	T							T	T					T	T								S		B	T	T	B		G	G	G	G
Template Predicted Secondary structure
Template SS confidence
		467	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.
		301	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380
Predicted Secondary structure
Query SS confidence
Query Sequence		K	V	Y	T	H	K	T	D	I	W	T	F	G	V	L	V	W	E	I	Y	S	D	G	A	E	P	Y	P	G	L	T	K	I	Q	T	R	A	K	I	V	V	N	D	Y	R	M	K	M	P	D	G	T	H	P	T	V	A	D	V	V	T	G	T	C	W	Q	K	N	P	E	K	R	S	T	M	D	S	I	H	K
Query Conservation
Alig confidence																																									.																					.
Template Conservation																																									.																					.
Template Sequence		Y	K	F	S	S	K	S	D	V	W	S	F	G	V	L	M	W	E	A	F	S	Y	G	Q	K	P	Y	R	G	M	K	G	S	E	V	T	A	M	L	.	E	K	G	E	R	M	G	C	P	A	G	C	P	R	E	M	Y	D	L	M	.	N	L	C	W	T	Y	D	V	E	N	R	P	G	F	A	A	V	E	L
Template Known Secondary structure																						T	T	T			S	S	T	T											.		T	T							T	T										.				T		S	S	T	T	T	S
Template Predicted Secondary structure																																									.																					.
Template SS confidence
		547	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.		.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.		.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.
		381	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		K	L	R	E	F	Y	E	S
Query Conservation
Alig confidence
Template Conservation
Template Sequence		R	L	R	N	Y	Y	Y	D
Template Known Secondary structure
Template Predicted Secondary structure
Template SS confidence
		625	.	.	.	.	630	.	.

---

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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D