|   |   |
125 | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
. | . | 190 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
| . | . | . | . | . | . | . | . |
|
|  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
L | I | N | H | D | S | I | V | A | N | K | K | L | G | E | G | A | F | G | D | V | F | I | A | E | L | D | Q | G | G | K | Q | E | V | A | V | K | T | M | R | A | E | A | T | R | E | A | R | L | R | F | M | K | E | A | R | L | M | R | K | Y | Q | H | . |
. |
. |
. |
. |
. |
. |
. |
K | H | V | V | K | L | I | G | V |
| Query Conservation |   |
  |
|   |   |   |   |   |   |   |   |   |   |
|
|   |
|   |
|
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |
|   |   |
|   |
| . | . | . | . | . | . | . | . |
|
|
|
|   |   |   |
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |
|   |
|   |   |   |
|
|   |
|   |
|
|   |
|   |   |
|   | . |   |   |   |   |   |   |   |
|
|
|
|   |
|   | . | . |   |   |   |   |   |   |   |   |   |   |   |
|
|   |
|
|   |   |
|   |
|   |   |   |   |   |   |   |   |   |   |
|
|   |   |   |   |   |
| Template Sequence |   |
D | L | F | N | G | R | Y | H | V | I | R | K | L | G | W | G | H | F | S | T | V | W | L | S | W | . |
D | I | Q | G | K | K | F | V | A | M | K | V | V | K | . |
. |
S | A | E | H | Y | T | E | T | A | L | D | E | I | R | L | L | K | S | V | R | N | S | D | P | N | D | P | N | R | E | M | V | V | Q | L | L | D | D |
| Template Known Secondary structure |   |
|  |  | T | T | T |  |  |  |  |  |  |  |  |  |
| S | S |  |  |  |  |  |  |  | . |  | S | S | S | S | S |  |  |  |  |  |  |  |
| . | . | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S | S |
| T | T |
| T | T | S | T | T | B |
|
|  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  | . |  |
|
|
|
|  |  |  |  |  |  |  |  |
| . | . |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
74 | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | |
. | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | |
|
. | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 |
|   |
|   |   |
197 | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | |
|
|
|
|
|
|
. | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | |
|
|
|
|
|
| Predicted Secondary structure |   |
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
| Query Sequence |   |
A | I | H | E | H | P | L | M | I | V | M | E | Y | C | P | N | G | S | L | . |
. |
. |
. |
. |
. |
. |
L | S | H | L | K | K | N | K | V | S | L | I | E | K | L | R | F | T | T | E | A | A | D | G | I | A | Y | L | E | R | S | K | C | I | H | R | D | I | A | A | R | N | C | L | L | S | A | K | . |
. |
. |
. |
. |
. |
| Query Conservation |   |
  |   |   |   |   |   |   |   |
|
|   |
|   |   |   |   |
|   |
| . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |
|
|   |   |   |   |   |
|   |   |
|   |   |   |
|   |   |   |   |   |   | . | . | . | . | . | . |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |
|   |   |
|
|
|   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
F | K | I | S | G | V | N | G | T | H | I | C | M | V | F | E | V | L | G | H | H | L | L | K | W | I | I | K | S | N | Y | Q | G | L | P | L | P | C | V | K | K | I | I | Q | Q | V | L | Q | G | L | D | Y | L | H | T | K | C | R | I | I | H | T | D | I | K | P | E | N | I | L | L | S | V | N | E | Q | Y | I | R | R |
| Template Known Secondary structure |   |
 |
|
| B |
| S | S |
| B |
|
|  |  |  |  |
|
|
|
|
| B |  |  |  |  |  |  |  | T | T | T | S |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S |
|  |  |
|
|
|
| S | G | G | G |  |  |  |
|
|
|  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
151 | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 |
|   |
|   |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
264 | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . |
| Predicted Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|  |  |
|  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
| Query SS confidence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
N | E | L | K | I | S | D | F | G | M | S | D | N | K | D | E | I | K | D | E | T | L | E | K | V | P | I | K | W | L | A | P | E | T | M | Q | E | K | V | Y | T | H | K | T | D | I | W | T | F | G | V | L | V | W | E | I | Y | S | D |
| Query Conservation |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |
|
|   |
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|
|
|   |   |   |   |   |   |   |   |   |   |
|
|
|
|
|   |
|   |   |
|   |
|
|   |
|   |
| Alig confidence |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |
|
|
|   |   |   |   |   |   | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |
|   |   |   |   |   |   |   |   | . |
| Template Sequence |   |
L | A | A | E | A | A | G | N | F | L | V | N | P | L | E | P | K | N | A | E | K | L | K | V | K | I | A | D | L | G | N | A | C | W | V | H | . |
. |
K | H | F | T | E | D | I | Q | T | R | Q | Y | R | S | L | E | V | L | I | G | S | G | Y | N | T | P | A | D | I | W | S | T | A | C | M | A | F | E | L | A | T | . |
| Template Known Secondary structure |   |
 |  | T | T |
|
|
|
|
| S |
|
| S | S |
| G | G | G | T | T | T |
|
|  |  |  |
|
|
| T | T |
|  |  | S | S | . | . |
|
| S |
| S |
|
| S |
| G | G | G |
|
|  |  |  |  |  | T |
|
|
|
| T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . |
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|  |  |
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
| . |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
231 | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | |
|
. | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | |
|   |
|   |   |
323 | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | 350 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
G | A | E | P | Y | P | G | L | T | K | I | Q | T | R | A | K | I | V | V | N | D | Y | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
R | M | K | M | P | D | G | T | H | P | T | V |
| Query Conservation |   |
|   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |
|   |   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
G | D | Y | L | F | E | P | H | S | G | E | E | Y | T | R | D | E | D | H | I | A | L | I | I | E | L | L | G | K | V | P | R | K | L | I | V | A | G | K | Y | S | K | E | F | F | T | K | K | G | D | L | K | H | I | T | K | L | K | P | W | G | L | F | E | V | L | V | E | K | Y | E | W | S | Q | E | E | A | A | G | F |
| Template Known Secondary structure |   |
S | S |
| S |
|
|
|
|
|
| S | S | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |
| S |
|
|  |  |  |  | T | T |
| T | T |  |  |  |  | B |
| S | S | S | S | B | S | S |
|
| S |
|
|
|
|
|  |  |  |  |  |  |  | T | T |
|
|
| T | T |  |  |  |  | T |
| Template Predicted Secondary structure |   |
|  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
547 | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . | . | . | 600 | . | . | . | . | . | . | . | . | . | 610 | . | . | . | . | . | . | . | . | . | 620 | . | . | . | . | . | . |
|   |
|   |   |
357 | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
A | D | V | V | T | G | T | C | W | Q | K | N | P | E | K | R | S | T | M | D | S | I | H | K | K | L | R | E | F | Y | E | S |
| Query Conservation |   |
  |   |   |
|   |   |   |
|   |   |   |
|
|   |   |
|
|
|   |   |   |
|   |   |   |
|   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
| Template Conservation |   |
  |
|
|
| . |   |   |
|
|   |   |
|
|   |   |
|   |
|
|   |
|   |
|   | . | . |
|
|
|
|   |   |
| Template Sequence |   |
T | D | F | L | . |
L | P | M | L | E | L | I | P | E | K | R | A | T | A | A | E | C | L | R | . |
. |
H | P | W | L | N | S |
| Template Known Secondary structure |   |
 |  |  |  | . |  |  |  | T |
| S | S | T | T | T | S |
|
|  |  |  |  |  | S | . | . |
| G | G | G | G |
|
| Template Predicted Secondary structure |   |
 |  |  |  | . |  |  |  |
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |
| . | . |
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
627 | . | . | 630 | |
. | . | . | . | . | . | . | . | . | 640 | . | . | . | . | . | . | . | . | . | |
|
650 | . | . | . | . | . |
|   |