Job Description Q22245 Confidence 100.00% Date Sun Jun 30 11:14:08 BST 2013 Rank 83 Aligned Residues 239 % Identity 24% Template c3vw6B_ PDB info PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:mitogen-activated protein kinase kinase kinase 5; PDBTitle: crystal structure of human apoptosis signal-regulating kinase 1 (ask1)2 with imidazopyridine inhibitor Resolution 2.40 Å

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		122	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	W	E	L	E	H	D	Q	I	T	I	H	K	K	L	G	E	G	A	F	G	E	V	S	S	G	V	M	K	F	K	K	G	M	K	T	V	Q	V	A	I	K	Q	V	K	L	D	K	T	G	K	A	K	I	K	D	F	L	A	E
Query Conservation
Alig confidence																													.	.	.	.																.	.	.	.	.	.	.	.
Template Conservation																													.	.	.	.																.	.	.	.	.	.	.	.
Template Sequence		E	Y	D	Y	E	Y	D	E	N	G	D	R	V	V	L	G	K	G	T	Y	G	I	V	Y	A	G	R	.	.	.	.	D	L	S	N	Q	V	R	I	A	I	K	E	I	P	E	.	.	.	.	.	.	.	.	Q	P	L	H	E	E
Template Known Secondary structure							B		T	T	S	S	B							S	S	S							.	.	.	.		T	T	T												.	.	.	.	.	.	.	.
Template Predicted Secondary structure																													.	.	.	.																.	.	.	.	.	.	.	.
Template SS confidence
		672	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.					.	700	.	.	.	.	.	.	.	.	.	710	.	.	.									.	.	.	.	.	.
		182	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.				.	.	.	230	.	.	.	.	.	.	.	.
Predicted Secondary structure																																															.	.	.
Query SS confidence																																															.	.	.
Query Sequence		A	R	T	M	R	K	L	G	H	Q	N	I	I	K	F	Y	G	V	G	V	L	Q	E	P	L	Y	L	V	M	E	L	A	V	N	G	A	L	D	S	F	L	K	K	N	E	.	.	.	D	L	S	V	D	K	K	T	E	M	I	L
Query Conservation																																															.	.	.
Alig confidence																																															.	.	.
Template Conservation
Template Sequence		I	A	L	H	K	H	L	K	H	K	N	I	V	Q	Y	L	G	S	F	S	E	N	G	F	I	K	I	F	M	E	Q	V	P	G	G	S	L	S	A	L	L	R	S	K	W	G	P	L	K	D	N	E	Q	T	I	G	F	Y	T	K
Template Known Secondary structure						T	T				T	T	B										T	T										T	T		B								T	T				T	T
Template Predicted Secondary structure
Template SS confidence
		726	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.
		239	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.			.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.
Predicted Secondary structure																												.	.
Query SS confidence																												.	.
Query Sequence		Q	A	A	W	G	L	E	Y	I	H	G	K	P	M	L	H	R	D	I	A	A	R	N	C	L	Y	.	.	T	D	G	K	V	K	I	S	D	F	G	L	T	R	N	G	T	V	Y	Q	I	K	P	N	T	K	S	P	I	R	W	L
Query Conservation																												.	.
Alig confidence																												.	.																		.	.	.	.	.	.	.	.	.
Template Conservation																																															.	.	.	.	.	.	.	.	.
Template Sequence		Q	I	L	E	G	L	K	Y	L	H	D	N	Q	I	V	H	R	D	I	K	G	D	N	V	L	I	N	T	Y	S	G	V	L	K	I	S	D	F	G	T	S	K	R	L	T	.	.	.	.	.	.	.	.	.	G	T	L	Q	Y	M
Template Known Secondary structure													T	T				S			S	G	G	G					T	T	T									S	S						.	.	.	.	.	.	.	.	.			G	G	G
Template Predicted Secondary structure																																															.	.	.	.	.	.	.	.	.
Template SS confidence
		786	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830										.	.	.	.	.	.
		297	.	.	300	.	.	.	.	.			.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.			.	.	.	.	.	.	.	.	350	.	.
Predicted Secondary structure											.	.																																					.	.
Query SS confidence											.	.																																					.	.
Query Sequence		A	I	E	T	I	K	T	M	I	.	.	C	S	E	K	T	D	V	W	A	Y	G	V	L	C	W	E	I	F	N	N	A	A	E	P	Y	P	G	M	K	P	A	D	V	A	T	Q	.	.	V	A	N	G	Y	R	M	P	P	Y	P
Query Conservation											.	.																																					.	.
Alig confidence											.	.																				.																	.	.
Template Conservation																																.
Template Sequence		A	P	E	I	I	D	K	G	P	R	G	Y	G	K	A	A	D	I	W	S	L	G	C	T	I	I	E	M	A	T	.	G	K	P	P	F	Y	E	L	G	E	P	Q	A	A	M	F	K	V	G	M	F	K	V	H	P	E	I	P	E
Template Known Secondary structure										G	G	G		S																		.	S	S		T	T	G	G	G		S												T							T
Template Predicted Secondary structure																																.
Template SS confidence
		847	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.		.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.
		353	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		H	A	Q	A	E	I	Q	T	M	M	A	R	C	N	A	E	N	P	N	D	R	P	S	M	A	E	I	A	E	I
Query Conservation
Alig confidence
Template Conservation
Template Sequence		S	M	S	A	E	A	K	A	F	I	L	K	C	F	E	P	D	P	D	K	R	A	C	A	N	D	L	L	V	D
Template Known Secondary structure		T	S												T		S		T	T	T	S								T	S
Template Predicted Secondary structure
Template SS confidence
		906	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.

No model constructed - rank, confidence too low

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D