|   |   |
128 | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | |
170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
| . |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
D | Q | I | T | I | H | K | K | L | G | E | G | A | F | G | E | V | S | S | G | V | M | K | F | K | K | G | M | K | T | V | Q | V | A | I | K | Q | V | K | L | D | K | . |
T | G | K | A | K | I | K | D | F | L | A | E | A | R | T | M | R |
| Query Conservation |   |
  |   |   |   |   |   |   |   |
|
|   |
|   |
|
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |   |   |   |   |   | . |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|   |
|   |   |   |   |   |
|
|   |
|   |
|
|   |
|
|   |
|   | . | . | . | . |   |   |   |
|   |   |   |
|
|
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |
|
|   |
| Template Sequence |   |
D | N | F | E | F | I | R | V | L | G | K | G | S | F | G | K | V | M | L | A | R | . |
. |
. |
. |
V | K | E | T | G | D | L | Y | A | V | K | V | L | K | K | D | V | I | L | Q | D | D | D | V | E | C | T | M | T | E | K | R | I | L | S |
| Template Known Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  | T | T |  |  |  |  |  |  |  | . | . | . | . |  | T | T | T |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T |  |  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  | . | . | . | . |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
353 | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | |
|
|
|
. | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . |
|   |
|   |   |
187 | . | |
. | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . |
| Predicted Secondary structure |   |
 |
| . |
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
K | L | . |
G | H | Q | N | I | I | K | F | Y | G | V | G | V | L | Q | E | P | L | Y | L | V | M | E | L | A | V | N | G | A | L | D | S | F | L | K | K | N | E | D | L | S | V | D | K | K | T | E | M | I | L | Q | A | A | W | G | L | E |
| Query Conservation |   |
  |
| . |   |
|
|
|
|
|   |   |   |
|   |   |   |   |   |   |   |   |   |
|
|   |
|
|   |   |   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |
| Alig confidence |   |
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |
|   |   |
|
|
|
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
L | A | R | N | H | P | F | L | T | Q | L | F | C | C | F | Q | T | P | D | R | L | F | F | V | M | E | F | V | N | G | G | D | L | M | F | H | I | Q | K | S | R | R | F | D | E | A | R | A | R | F | Y | A | A | E | I | I | S | A | L | M |
| Template Known Secondary structure |   |
 | T | T | T |
| T | T | B |
|
|  |  |  |  |  |  |
| S | S |  |  |  |  |  |  |  |
|
|
| S |
| B |  |  |  |  |  |  |  |  | S | S |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |
|
|
|
|
|  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
409 | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . |
|   |
|   |   |
246 | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |
|
|
|
|
|  |  |  |
|
|
|  |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
Y | I | H | G | K | P | M | L | H | R | D | I | A | A | R | N | C | L | Y | T | D | G | K | V | K | I | S | D | F | G | L | T | R | N | G | T | V | Y | Q | I | K | P | N | T | K | S | P | I | R | W | L | A | I | E | T | I | K | T | M | I |
| Query Conservation |   |
  |
|
|   |   |   |   |   |
|   |   |
|   |   |   |
|
|   |   |   |   |   |   |   |
|
|   |
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
F | L | H | D | K | G | I | I | Y | R | D | L | K | L | D | N | V | L | L | D | H | E | G | H | C | K | L | A | D | F | . |
. |
. |
. |
. |
. |
. |
G | M | C | K | E | G | I | C | G | T | P | D | Y | I | A | P | E | I | L | Q | E | M | L |
| Template Known Secondary structure |   |
 |  |  |  | T | T |
| B |
|
|
|
|
| G | G | G |  |  |  |
| T | T | S |
|  |  |  |
|
|
| . | . | . | . | . | . | . | T | T |
| B |
| S |
|
|
|
| G | G | G |
|
|  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
469 | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
. | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . |
|   |
|   |   |
306 | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
C | S | E | K | T | D | V | W | A | Y | G | V | L | C | W | E | I | F | N | N | A | A | E | P | Y | P | G | M | K | P | A | D | V | A | T | Q | V | A | N | G | Y | R | M | P | P | Y | P | H | A | Q | A | E | I | Q | T | M | M | A | R | C |
| Query Conservation |   |
  |   |   |
|
|
|
|
|
|   |
|
|   |
|   |
|
|   |
|   |
|   |   |
|
|   |   |   |   |   |   |   |
|   |   |   |
|   |   |
|   |
|   |   |   |
|   |   |   |
|   |   |
|   |   |
|
|   |   |
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |
|
|   |
|   |
|   |
|   |   |
|   |   |   | . |
|   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |   | . |   |   |   |   |
|   |   |   |
|   |   |   |   |   |
|
|   |   |   |
| Template Sequence |   |
Y | G | P | A | V | D | W | W | A | M | G | V | L | L | Y | E | M | L | C | . |
G | H | A | P | F | E | A | E | N | E | D | D | L | F | E | A | I | L | N | D | . |
E | V | V | Y | P | T | W | L | H | E | D | A | T | G | I | L | K | S | F |
| Template Known Secondary structure |   |
| T | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | S | S |
| S | S |
|
| S | S |  |  |  |  |  |  |  |  |  |  |
| . |
|
|
|
|
| T | T | S |
|  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
| . |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
| . |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
531 | . | . | . | . | . | . | . | . | 540 | . | . | . | . | . | . | . | . | . | |
550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | |
570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . |
|   |
|   |   |
366 | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
N | A | E | N | P | N | D | R | P | S | M | A | E | I | A | E | I | L | Q | R | V | T | E | T | P | R | P | N | F | T | A | I | A | K | K | E | A | E | E | L | L | L | M | N | S | V | T | T | K | T | T | A | R | R | K | K | S | N |
| Query Conservation |   |
  |   |   |   |
|   |   |
|
|
|   |   |
|
|   |   |   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|   |   |
|
|   |   |
|   |
|
|   |   |   |   |   |   |   |   |
|
|   | . | . | . |
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
M | T | K | N | P | T | M | R | L | G | S | L | T | Q | G | G | E | H | A | I | L | R | . |
. |
. |
H | P | F | F | K | E | I | D | W | A | Q | L | N | H | R | Q | I | E | P | P | F | R | P | R | I | K | S | R | E | D | V | S | N |
| Template Known Secondary structure |   |
T |
| S | S | G | G | G | S | T | T | S | G | G | G | T |
| T |  |  |  |  | T | . | . | . | S | G | G | G | T | T |
|
|  |  |  |  |  | T | T |
| S |
|
| S |
|
|
|
|
|
| S | T | T |
|
| T | T |
| Template Predicted Secondary structure |   |
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |
| . | . | . |
|  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
589 | 590 | . | . | . | . | . | . | . | . | . | 600 | . | . | . | . | . | . | . | . | . | 610 | |
|
|
. | . | . | . | . | . | . | . | . | 620 | . | . | . | . | . | . | . | . | . | 630 | . | . | . | . | . | . | . | . | . | 640 | . | . | . |
|   |