|   |   |
121 | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 |
| Predicted Secondary structure |   |
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
Q | F | W | E | L | E | H | D | Q | I | T | I | H | K | K | L | G | E | G | A | F | G | E | V | S | S | G | V | M | K | F | K | K | G | M | K | T | V | Q | V | A | I | K | Q | V | K | L | D | K | T | G | K | A | K | I | K | D | F | L | A |
| Query Conservation |   |
  |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|
|   |
|   |
|
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |
|   |   |   |   |
|   |
|   |   |   |
|
|   |
|   |
|
|   |
|
|   |
|   |   |   | . | . | . | . | . |   |
|   |   |
|
|
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
Q | S | M | S | V | K | G | R | I | Y | S | I | L | K | Q | I | G | S | G | G | S | S | K | V | F | Q | V | L | N | E | . |
. |
. |
. |
. |
K | K | Q | I | Y | A | I | K | Y | V | N | L | E | E | A | D | N | Q | T | L | D | S | Y | R | N |
| Template Known Secondary structure |   |
|  |  |  |  | T | T |  |  |  |  |  |  |  |  |  |  |
|
| S | S |  |  |  |  |  |  |  |
| T | . | . | . | . | . | T |
|
|  |  |  |  |  |  |  |  |
| S | S |
|
|  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |
| . | . | . | . | . |
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
516 | . | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540 | . | . | . | . | . | |
|
|
|
|
. | . | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 |
|   |
|   |   |
181 | . | . | . | . | . | . | . | . | |
|
190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |
|
| . | . |
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
E | A | R | T | M | R | K | L | G | . |
. |
H | Q | N | I | I | K | F | Y | G | V | G | V | L | Q | E | P | L | Y | L | V | M | E | L | A | V | N | G | A | L | D | S | F | L | K | K | N | E | D | L | S | V | D | K | K | T | E | M | I | L |
| Query Conservation |   |
|   |   |   |
|   |   |
|   | . | . |
|
|
|
|
|   |   |   |
|   |   |   |   |   |   |   |   |   |
|
|   |
|
|   |   |   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|
|   |
|
|   |   |
|   |   |   |   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
E | I | A | Y | L | N | K | L | Q | Q | H | S | D | K | I | I | R | L | Y | D | Y | E | I | T | D | Q | Y | I | Y | M | V | M | E | C | G | N | I | D | L | N | S | W | L | K | K | K | . |
K | S | I | D | P | W | E | R | K | S | Y | W | K |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  | G | G | G |
| T | T | B |
|
|  |  |  |  |  |  |
| S | S |  |  |  |  |  |  |
|
|
| S |  |  |  |  |  |  |  |  |  |
| . | S | S |
|
|  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
571 | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . | . | . | 600 | . | . | . | . | . | . | . | . | . | 610 | . | . | . | . | . | . | |
. | . | . | 620 | . | . | . | . | . | . | . | . | . |
|   |
|   |   |
239 | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |
|
|
|
|
|  |  |  |
|
|
|  |  |
|
|
|
|
|  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
Q | A | A | W | G | L | E | Y | I | H | G | K | P | M | L | H | R | D | I | A | A | R | N | C | L | Y | T | D | G | K | V | K | I | S | D | F | G | L | T | R | N | G | T | V | Y | Q | I | K | P | N | T | K | S | P | I | R | W | L | A | I |
| Query Conservation |   |
  |
|   |   |   |
|   |   |
|
|   |   |   |   |   |
|   |   |
|   |   |   |
|
|   |   |   |   |   |   |   |
|
|   |
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
N | M | L | E | A | V | H | T | I | H | Q | H | G | I | V | H | S | D | L | K | P | A | N | F | L | I | V | D | G | M | L | K | L | I | D | F | G | I | A | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
N | Q | G | T | V | N | Y | M | P | P | E |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  | T | T |
|
|
|
|
|
|
| G | G | G |  |  |  |  | T | T |  |  |  |  |
|
|
| S | S | S | . | . | . | . | . | . | . | . | . | . |
|
|
|
| G | G | G |
|
|  |  |
| Template Predicted Secondary structure |   |
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
630 | . | . | . | . | . | . | . | . | . | 640 | . | . | . | . | . | . | . | . | . | 650 | . | . | . | . | . | . | . | . | . | 660 | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
. | 670 | . | . | . | . | . | . | . | . | . |
|   |
|   |   |
299 | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | |
. | . | . | . | . | . | . | 340 | . | . | . | . | |
. | . | . | . | . | 350 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
| . |
|
|  |  |  |  |  |  |  |  |  |
| . |
|
|
|
|
|
|
|
|
|
|
|  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
E | T | I | K | T | M | I | C | S | E | K | T | D | V | W | A | Y | G | V | L | C | W | E | I | F | N | N | A | A | E | P | Y | P | G | . |
M | K | P | A | D | V | A | T | Q | V | A | N | . |
G | Y | R | M | P | P | Y | P | H | A | Q | A |
| Query Conservation |   |
|   |   |   |   |   |   |   |   |   |
|
|
|
|
|
|   |
|
|   |
|   |
|
|   |
|   |
|   |   |
|
|   |   | . |   |   |   |   |   |
|   |   |   |
|   |   | . |
|   |
|   |   |   |
|   |   |   |
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|
|
|
|   |
|
|
|
|
|
| . |
|   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
| Template Sequence |   |
A | I | K | D | M | S | K | I | S | P | K | S | D | V | W | S | L | G | C | I | L | Y | Y | M | T | Y | . |
G | K | T | P | F | Q | Q | I | I | N | Q | I | S | K | L | H | A | I | I | D | P | N | H | E | I | E | F | P | D | I | P | E | K |
| Template Known Secondary structure |   |
 |  | T | T |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | S | S |
| T | T | T | T |
|
| S |  |  |  |  |  |  |  |  |  |
| T | T | S |
|
|
|
|
|
|
| S |
|  |
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | . |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
694 | . | . | . | . | . | 700 | . | . | . | . | . | . | . | . | . | 710 | . | . | . | . | . | . | . | . | . | |
720 | . | . | . | . | . | . | . | . | . | 730 | . | . | . | . | . | . | . | . | . | 740 | . | . | . | . | . | . | . | . | . | 750 | . | . |
|   |
|   |   |
357 | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
E | I | Q | T | M | M | A | R | C | N | A | E | N | P | N | D | R | P | S | M | A | E | I | A | E |
| Query Conservation |   |
  |
|   |   |
|
|   |   |
|   |   |   |   |
|   |   |
|
|
|   |   |
|
|   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |
|   |   |
|
|   |   |   |
|   |   |
|
|   |   |
|   |
|   |   |
|
|
|   |
| Template Sequence |   |
D | L | Q | D | V | L | K | C | C | L | K | R | D | P | K | Q | R | I | S | I | P | E | L | L | A |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  | T |
| S | S | T | T | T | S |
|
|  |  |  |  |  | T |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
763 | . | . | . | . | . | . | 770 | . | . | . | . | . | . | . | . | . | 780 | . | . | . | . | . | . | . |
|   |