Email l.a.kelley@imperial.ac.uk Description G5EC24 Date Fri May 3 21:06:01 BST 2013 Unique Job ID 84e226cc6a76541a

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3ps5A_ 100.0 41 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 2 c2b3oA_ 100.0 42 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 3 c2shpA_ 100.0 44 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 4 c1yguA_ 100.0 28 PDB header:hydrolase Chain: A: PDB Molecule:leukocyte common antigen; PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 cd45 with a ptyr peptide 5 c2nlkA_ 100.0 42 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, g variant PDBTitle: crystal structure of d1 and d2 catalytic domains of human protein2 tyrosine phosphatase gamma (d1+d2 ptprg) 6 c3sr9A_ 100.0 32 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase s; PDBTitle: crystal structure of mouse ptpsigma 7 c1larB_ 100.0 37 PDB header:hydrolase Chain: B: PDB Molecule:protein (lar); PDBTitle: crystal structure of the tandem phosphatase domains of rptp2 lar 8 d1wcha_ 100.0 36 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 9 d1jlna_ 100.0 39 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 10 c2jjdA_ 100.0 33 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase epsilon; PDBTitle: protein tyrosine phosphatase, receptor type, e isoform 11 c3s3fA_ 100.0 37 PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:tyrosine-protein phosphatase 10d; PDBTitle: crystal structure of the catalytic domain of ptp10d from drosophila2 melanogaster with a small molecule inhibitor vanadate 12 c2nz6A_ 100.0 34 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase eta; PDBTitle: crystal structure of the ptprj inactivating mutant c1239s 13 c2pa5A_ 100.0 36 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 9; PDBTitle: crystal structure of human protein tyrosine phosphatase ptpn9 14 d1lara1 100.0 41 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 15 c3i36A_ 100.0 36 PDB header:hydrolase Chain: A: PDB Molecule:vascular protein tyrosine phosphatase 1; PDBTitle: crystal structure of rat protein tyrosine phosphatase eta catalytic2 domain 16 c2bzlA_ 100.0 34 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of the human protein tyrosine phosphatase2 n14 at 1.65 a resolution 17 d2shpa1 100.0 48 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 18 c2qdmA_ 100.0 36 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 7; PDBTitle: crystal structure of the heptp catalytic domain c270s/d236a/q314a2 mutant 19 c2oc3A_ 100.0 39 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type PDBTitle: crystal structure of the catalytic domain of human protein2 tyrosine phosphatase non-receptor type 18 20 c2c7sA_ 100.0 40 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase kappa; PDBTitle: crystal structure of human protein tyrosine phosphatase2 kappa at 1.95a resolution 21 d1fpra_ not modelled 100.0 47 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 22 c2qcjB_ not modelled 100.0 38 PDB header:hydrolase Chain: B: PDB Molecule:tyrosine-protein phosphatase non-receptor type PDBTitle: native structure of lyp 23 c2hy3A_ not modelled 100.0 41 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase gamma; PDBTitle: crystal structure of the human tyrosine receptor phosphate gamma in2 complex with vanadate 24 d2f71a1 not modelled 100.0 38 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 25 d1rpma_ not modelled 100.0 39 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 26 d1yfoa_ not modelled 100.0 39 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 27 c2vexA_ not modelled 100.0 38 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 1; PDBTitle: crystal strucutre of protein tyrosine phosphatase 1b in2 complex with an isothiazolidinone-containing inhibitor 28 d1larb1 not modelled 100.0 44 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 29 c2h04A_ not modelled 100.0 39 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, b,; PDBTitle: structural studies of protein tyrosine phosphatase beta2 catalytic domain in complex with inhibitors 30 c2qepA_ not modelled 100.0 33 PDB header:hydrolase Chain: A: PDB Molecule:receptor-type tyrosine-protein phosphatase n2; PDBTitle: crystal structure of the d1 domain of ptprn2 (ia2beta) 31 c2g59B_ not modelled 100.0 34 PDB header:hydrolase Chain: B: PDB Molecule:receptor-type tyrosine-protein phosphatase o; PDBTitle: crystal structure of the catalytic domain of protein2 tyrosine phosphatase from homo sapiens 32 c2bijA_ not modelled 100.0 38 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type 5; PDBTitle: crystal structure of the human protein tyrosine phosphatase2 ptpn5 (step, striatum enriched enriched phosphatase) 33 d1l8ka_ not modelled 100.0 35 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 34 c1l8kA_ not modelled 100.0 35 PDB header:hydrolase Chain: A: PDB Molecule:t-cell protein-tyrosine phosphatase; PDBTitle: t cell protein-tyrosine phosphatase structure 35 c2b49A_ not modelled 100.0 36 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, non-receptor type 3; PDBTitle: crystal structure of the catalytic domain of protein tyrosine2 phosphatase, non-receptor type 3 36 c2i75A_ not modelled 100.0 35 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 4; PDBTitle: crystal structure of human protein tyrosine phosphatase n4 (ptpn4) 37 d1lara2 not modelled 100.0 41 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 38 c1g4wR_ not modelled 100.0 16 PDB header:signaling protein Chain: R: PDB Molecule:protein tyrosine phosphatase sptp; PDBTitle: crystal structure of the salmonella tyrosine phosphatase2 and gtpase activating protein sptp 39 c3m4uB_ not modelled 100.0 29 PDB header:hydrolase Chain: B: PDB Molecule:tyrosine specific protein phosphatase, putative; PDBTitle: crystal structure of trypanosoma brucei protein tyrosine phosphatase2 tbptp1 40 c3jrlA_ not modelled 100.0 50 PDB header:hydrolase Chain: A: PDB Molecule:oncogenic tyrosine phosphatase shp2; PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor 41 c4az1B_ not modelled 100.0 30 PDB header:hydrolase Chain: B: PDB Molecule:tyrosine specific protein phosphatase; PDBTitle: crystal structure of the trypanosoma cruzi protein tyrosine2 phosphatase tcptp1, a potential therapeutic target for chagas'3 disease 42 d1p15a_ not modelled 100.0 41 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 43 d1lyva_ not modelled 100.0 19 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 44 d1g4us2 not modelled 100.0 19 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 45 c2oq1A_ not modelled 100.0 30 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 46 c2ozoA_ not modelled 100.0 29 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 47 c4fl2A_ not modelled 100.0 29 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 48 c3gqiB_ not modelled 100.0 28 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 49 c1a81E_ not modelled 100.0 23 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 50 c3or8A_ not modelled 100.0 14 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 51 d1v3aa_ not modelled 100.0 26 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 52 d1rxda_ not modelled 100.0 28 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 53 c2xp1A_ not modelled 100.0 17 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 54 c3s4oB_ not modelled 99.9 24 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein tyrosine phosphatase-like protein; PDBTitle: protein tyrosine phosphatase (putative) from leishmania major 55 c3rz2B_ not modelled 99.9 26 PDB header:hydrolase Chain: B: PDB Molecule:protein tyrosine phosphatase type iva 1; PDBTitle: crystal of prl-1 complexed with peptide 56 d2oq1a1 not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 57 c2y3aB_ not modelled 99.9 22 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 58 d2shpa2 not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 59 d1pica_ not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 60 d1a81a1 not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 61 c1x6cA_ not modelled 99.9 28 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 62 c3hizB_ not modelled 99.9 19 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 63 d1a81e1 not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 64 c2hdxB_ not modelled 99.9 25 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 65 d2oq1a2 not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 66 c2ysxA_ not modelled 99.9 26 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 67 d1qada_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 68 d3c7ia1 not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 69 c2fo0A_ not modelled 99.9 27 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 70 c2lqnA_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 71 c2eo6A_ not modelled 99.9 21 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 72 c2crhA_ not modelled 99.9 21 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 73 d1fhsa_ not modelled 99.9 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 74 c1ka6A_ not modelled 99.9 25 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 75 c2ci8A_ not modelled 99.9 28 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 76 d1ayaa_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 77 c2eobA_ not modelled 99.9 25 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 78 d1a81a2 not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 79 d1a81e2 not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 80 c2dlyA_ not modelled 99.9 24 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 81 d2izva2 not modelled 99.9 18 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 82 c2dlzA_ not modelled 99.9 25 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 83 d1d4ta_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 c2gsbA_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 85 c1oplA_ not modelled 99.9 27 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 86 c2ablA_ not modelled 99.9 26 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 87 d2shpa3 not modelled 99.9 39 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 88 d2qmsa1 not modelled 99.9 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 89 c2lctA_ not modelled 99.9 22 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 90 d1blja_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 91 d1nrva_ not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 92 c2ge9A_ not modelled 99.9 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 93 d1r1qa_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 94 d1rjaa_ not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 95 c1k9aB_ not modelled 99.9 25 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 96 d1xa6a2 not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 97 d1lkka_ not modelled 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 98 c2augB_ not modelled 99.8 25 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 99 c2eo3A_ not modelled 99.8 25 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 100 d1i3za_ not modelled 99.8 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 101 d1ohea2 not modelled 99.8 26 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 102 d1k9aa2 not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 103 d1opka2 not modelled 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 104 d1bkla_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 105 d1jyra_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 106 d1jwoa_ not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 107 c1y57A_ not modelled 99.8 23 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 108 d2eyva1 not modelled 99.8 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 109 c2hmhA_ not modelled 99.8 22 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 110 d1mila_ not modelled 99.8 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 111 d1csya_ not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 112 c3nhnA_ not modelled 99.8 21 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 113 d1qcfa2 not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 114 c2vifA_ not modelled 99.8 21 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 115 d1luia_ not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 116 c2el8A_ not modelled 99.8 24 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 117 c2knoA_ not modelled 99.8 18 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 118 d1g83a2 not modelled 99.8 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 119 c2c9wA_ not modelled 99.8 32 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 120 d1f2fa_ not modelled 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain