Job Description G5EC24 Confidence 100.00% Date Fri May 3 21:06:01 BST 2013 Rank 1 Aligned Residues 500 % Identity 41% Template c3ps5A_ PDB info PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 Resolution 3.10 Å Model Dimensions (Å) X:68.757 Y:92.125 Z:51.708

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		10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		N	F	Y	Y	R	V	N	G	E	K	A	E	E	L	L	K	E	Y	G	E	D	G	D	F	L	L	R	Y	S	E	S	N	P	Q	N	F	S	I	S	V	R	V	A	E	D	K	I	L	H	I	K	V	T	K	Y	E	S	D	M	L	S	I	F	E	D	E	R	T	T	P	N	Q	F	G	S	I	T	E	L	A
Query Conservation
Alig confidence																																											.														.										.	.	.	.	.
Template Conservation																																											.														.										.	.	.	.	.
Template Sequence		W	F	H	R	D	L	S	G	L	D	A	E	T	L	L	K	G	R	G	V	H	G	S	F	L	A	R	P	S	R	K	N	Q	G	D	F	S	L	S	V	R	.	V	G	D	Q	V	T	H	I	R	I	Q	N	S	.	G	D	F	Y	D	L	Y	G	G	.	.	.	.	.	E	K	F	A	T	L	T	E	L	V
Template Known Secondary structure					S	S																T	T								S	S	S	T	T	S							.		T	T											.	S	S				S	S	S	S	.	.	.	.	.			B	S	S
Template Predicted Secondary structure																																											.														.										.	.	.	.	.
Template SS confidence
		4	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.		.	.	.	.	.	50	.	.	.	.	.	.	.		.	.	60	.	.	.	.	.	.						.	.	.	70	.	.	.	.	.	.
		90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.		.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.
Predicted Secondary structure																																																													.
Query SS confidence																																																													.
Query Sequence		E	F	Y	M	E	F	P	E	K	L	R	E	K	N	G	L	F	L	E	L	K	K	P	V	Y	V	P	Y	H	L	E	A	C	A	E	E	Q	R	R	T	Q	L	Y	R	W	W	H	G	N	L	P	A	S	S	A	N	K	L	L	.	Q	T	E	K	N	G	T	Y	L	L	R	A	S	Q	H	I	P	G	A	L
Query Conservation																																																													.
Alig confidence																											.	.	.	.	.	.	.	.	.	.	.																								.
Template Conservation																											.	.	.	.	.	.	.	.	.	.	.
Template Sequence		E	Y	Y	T	Q	Q	Q	G	V	L	Q	D	R	D	G	T	I	I	H	L	K	Y	P	L	N	.	.	.	.	.	.	.	.	.	.	.	C	S	D	P	T	S	E	R	W	Y	H	G	H	M	S	G	G	Q	A	E	T	L	L	Q	A	K	G	E	P	W	T	F	L	V	R	E	S	L	S	Q	P	G	D	F
Template Known Secondary structure						T	T	S	S			B		S	S			B						B			.	.	.	.	.	.	.	.	.	.	.				S			S	T	T				S																T	T								S	S	S	T	T
Template Predicted Secondary structure																											.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		77	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.												.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.
		169	170	.	.	.	.	.	.										.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.
Predicted Secondary structure										.	.	.	.	.	.	.	.	.
Query SS confidence										.	.	.	.	.	.	.	.	.
Query Sequence		V	I	S	A	K	T	E	G	.	.	.	.	.	.	.	.	.	Q	V	V	H	L	T	I	Y	Q	D	P	S	T	G	R	F	N	I	D	G	D	R	T	K	F	Q	S	A	W	L	L	I	D	S	Y	S	K	N	P	I	V	E	K	G	E	A	S	R	V	L	Y	L	E	E	P	L	F	N	T	F	I	E	A
Query Conservation										.	.	.	.	.	.	.	.	.
Alig confidence										.	.	.	.	.	.	.	.	.												.	.										.																					.	.
Template Conservation																														.	.										.																					.	.
Template Sequence		V	L	S	V	L	S	D	Q	P	K	A	G	P	G	S	P	L	R	V	T	H	I	K	V	M	C	E	G	.	.	G	R	Y	T	V	G	G	L	E	.	T	F	D	S	L	T	D	L	V	E	H	F	K	K	T	G	I	E	E	A	.	.	S	G	A	F	V	Y	L	R	Q	P	Y	Y	A	T	R	V	N	A
Template Known Secondary structure											S	S	S	T	T	S										B		G	G	.	.	G		B	B	S	S	S	S		.		B	S	S											S		B			T	.	.	T	S			B													G
Template Predicted Secondary structure																														.	.										.																					.	.
Template SS confidence
		146	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.			.	.	.	.	.	.	180	.	.		.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.			.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220
		240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.		.	.	.
Predicted Secondary structure																																																																														.
Query SS confidence																																																																														.
Query Sequence		D	L	F	V	D	R	F	E	I	I	R	R	P	I	N	P	R	E	S	M	E	K	T	G	I	S	E	E	F	D	R	L	S	Q	E	A	L	P	A	E	Q	Y	L	S	K	R	E	G	R	R	P	V	N	A	E	K	N	R	Y	K	N	I	V	P	F	D	H	T	R	V	I	L	T	D	R	P	.	N	T	P
Query Conservation																																																																														.
Alig confidence															.																												.	.																																		.
Template Conservation															.																												.	.
Template Sequence		A	D	I	E	N	R	V	L	E	L	N	K	K	.	Q	E	S	E	D	T	A	K	A	G	F	W	E	E	F	E	S	L	Q	K	Q	E	V	K	N	L	H	.	.	Q	R	L	E	G	Q	R	P	E	N	K	G	K	N	R	Y	K	N	I	L	P	F	D	H	S	R	V	I	L	Q	G	R	D	S	N	I	P
Template Known Secondary structure		G	G												.			S	S	S															G	G	G	G	G				.	.			T	G	G	G		G	G	G	G	G	G		S		S	S					T	T	T						S			S	S	S	T
Template Predicted Secondary structure															.																												.	.
Template SS confidence
		221	.	.	.	.	.	.	.	.	230	.	.	.		.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260			.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.
		319	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.		.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.
Predicted Secondary structure																																																																	.
Query SS confidence																																																																	.
Query Sequence		G	S	D	Y	I	N	A	S	Y	V	R	F	E	N	S	Q	R	T	K	N	V	T	F	A	C	E	K	S	F	I	A	T	Q	G	C	L	E	T	T	I	S	D	F	W	S	M	V	W	Q	E	N	S	R	V	I	V	M	P	T	M	E	N	E	.	R	K	E	K	C	A	R	Y	W	P	A	E	V	N	K	P
Query Conservation																																																																	.
Alig confidence																		.	.	.	.	.																																											.													.
Template Conservation																		.	.	.	.	.																																																								.
Template Sequence		G	S	D	Y	I	N	A	N	Y	I	K	N	Q	L	L	G	.	.	.	.	.	P	D	E	N	A	K	T	Y	I	A	S	Q	G	C	L	E	A	T	V	N	D	F	W	Q	M	A	W	Q	E	N	S	R	V	I	V	M	T	T	R	E	V	E	K	G	R	N	K	C	V	P	Y	W	P	E	V	.	G	M	Q
Template Known Secondary structure		T	T	T										S	S	S		.	.	.	.	.	T	T														T	T	T											T	T								S		S	B	S	S	S	S	B	S					S			B	.	T
Template Predicted Secondary structure																		.	.	.	.	.																																																								.
Template SS confidence
		298	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.						.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.		.	370	.
		398	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.				.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.
Predicted Secondary structure																																																															.	.	.
Query SS confidence																																																															.	.	.
Query Sequence		E	V	H	G	D	I	S	L	T	C	T	I	E	R	K	V	Q	R	A	V	S	D	E	V	K	A	E	L	E	Q	E	K	T	N	R	I	A	K	G	L	V	P	E	A	E	L	N	G	D	G	I	S	Y	I	L	R	T	L	V	M	K	.	.	.	K	G	K	D	T	R	E	I	R	Q	L	Q	Y	L	T	W
Query Conservation																																																															.	.	.
Alig confidence																			.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.											.	.	.
Template Conservation																			.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		R	A	Y	G	P	Y	S	V	T	N	C	G	E	H	D	T	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	E	Y	K	L	R	T	L	Q	V	S	P	L	D	N	G	D	L	I	R	E	I	W	H	Y	Q	Y	L	S	W
Template Known Secondary structure					T	T												S	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	S											S	S			S
Template Predicted Secondary structure																			.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		372	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.																																			.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.
		475	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		P	D	H	G	C	P	L	H	P	Y	A	V	L	N	F	L	E	D	V	D	R	E	Y	D	Y	F	N	A	Q	P	I	A	A	S	L	P	Q	G	P	I	V	V	H	C	S	A	G	I	G	R	T	G	T	V	L	V	L	D	A	L	L	N	Q	V	K	K	V	G	L	L	C	P	M	D	V	Y	K	M	V	K
Query Conservation
Alig confidence																														.	.	.	.	.	.	.	.
Template Conservation																														.	.	.	.	.	.	.	.
Template Sequence		P	D	H	G	V	P	S	E	P	G	G	V	L	S	F	L	D	Q	I	N	Q	R	Q	E	S	L	P	H	.	.	.	.	.	.	.	.	A	G	P	I	I	V	H	S	S	A	G	I	G	R	T	G	T	I	I	V	I	D	M	L	M	E	N	I	S	T	K	G	L	D	C	D	I	D	I	Q	K	T	I	Q
Template Known Secondary structure			S	S	S	S		S		S																		T	T	.	.	.	.	.	.	.	.									S	S	S	S																					S	S
Template Predicted Secondary structure																														.	.	.	.	.	.	.	.
Template SS confidence
		418	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.									.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.
		555	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	V	R	T	Y	R	S	G	L	V	Q	T	E	Q	Q	Y	Q	F	L	Y	K	A	L	A	F	Y	L	K	N
Query Conservation
Alig confidence
Template Conservation
Template Sequence		M	V	R	A	Q	R	S	G	M	V	Q	T	E	A	Q	Y	K	F	I	Y	V	A	I	A	Q	F	I	E	T
Template Known Secondary structure					T	T	S	T	T	S	S		S
Template Predicted Secondary structure
Template SS confidence
		490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.