Job Description G5EC24 Confidence 100.00% Date Fri May 3 21:06:01 BST 2013 Rank 40 Aligned Residues 246 % Identity 50% Template c3jrlA_ PDB info PDB header:hydrolase Chain: A: PDB Molecule:oncogenic tyrosine phosphatase shp2; PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor Resolution 2.00 Å

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		282	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.		.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Predicted Secondary structure																																							.
Query SS confidence																																							.
Query Sequence		L	S	K	R	E	G	R	R	P	V	N	A	E	K	N	R	Y	K	N	I	V	P	F	D	H	T	R	V	I	L	T	D	R	P	N	T	P	.	G	S	D	Y	I	N	A	S	Y	V	R	F	E	N	S	Q	R	T	K	N	V	T	F	A	C	E	K	S	F	I	A	T	Q	G	C	L	E	T	T	I	S	D
Query Conservation																																							.
Alig confidence																																							.												.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																																			.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		Y	S	R	K	E	G	Q	R	Q	E	N	K	N	K	N	R	Y	K	N	I	L	P	F	D	H	T	R	V	V	L	H	D	G	D	P	N	E	P	V	S	D	Y	I	N	A	N	I	I	M	.	.	.	.	.	.	.	.	.	.	.	.	.	P	K	K	S	Y	I	A	T	Q	G	C	L	Q	N	T	V	N	D
Template Known Secondary structure						G	G	G	S	G	G	G	G	G	G		S	S	T	T					T	T	T	B					S			T	T	S	S			S			S						.	.	.	.	.	.	.	.	.	.	.	.	.													T	T	T
Template Predicted Secondary structure																																																			.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		263	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.														.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.
		361	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.		.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																							.
Query SS confidence																							.
Query Sequence		F	W	S	M	V	W	Q	E	N	S	R	V	I	V	M	P	T	M	E	N	E	.	R	K	E	K	C	A	R	Y	W	P	A	E	V	N	K	P	E	V	H	G	D	I	S	L	T	C	T	I	E	R	K	V	Q	R	A	V	S	D	E	V	K	A	E	L	E	Q	E	K	T	N	R	I	A	K	G	L	V	P
Query Conservation																							.
Alig confidence																							.													.																					.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																				.																					.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		F	W	R	M	V	F	Q	E	N	S	R	V	I	V	M	T	T	K	E	V	E	R	G	K	S	K	C	V	K	Y	W	P	D	E	.	Y	A	L	K	E	Y	G	V	M	R	V	R	N	V	K	E	S	A	A	H	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure									T	T								S		S			T	T								S			T	.	T						T	T												S	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure																																				.																					.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		341	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.		.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.
		440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.				.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.
Predicted Secondary structure																								.	.	.
Query SS confidence																								.	.	.
Query Sequence		E	A	E	L	N	G	D	G	I	S	Y	I	L	R	T	L	V	M	K	K	G	K	.	.	.	D	T	R	E	I	R	Q	L	Q	Y	L	T	W	P	D	H	G	C	P	L	H	P	Y	A	V	L	N	F	L	E	D	V	D	R	E	Y	D	Y	F	N	A	Q	P	I	A	A	S	L	P	Q	G	P	I	V	V
Query Conservation																								.	.	.
Alig confidence		.	.	.	.	.	.	.	.	.														.	.	.																																						.	.	.	.	.	.	.	.
Template Conservation		.	.	.	.	.	.	.	.	.																																																						.	.	.	.	.	.	.	.
Template Sequence		.	.	.	.	.	.	.	.	.	D	Y	T	L	R	E	L	K	L	S	K	V	G	Q	G	N	T	E	R	T	V	W	Q	Y	H	F	R	T	W	P	D	H	G	V	P	S	D	P	G	G	V	L	D	F	L	E	E	V	H	H	K	Q	E	.	.	.	.	.	.	.	.	S	I	M	D	A	G	P	V	V	V
Template Known Secondary structure		.	.	.	.	.	.	.	.	.	S											T	T		S	S															S	S	S			S	S	T																.	.	.	.	.	.	.	.	T	S	T	T
Template Predicted Secondary structure		.	.	.	.	.	.	.	.	.																																																						.	.	.	.	.	.	.	.
Template SS confidence
											395	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.									.	.	450	.	.	.	.	.	.	.
		517	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		H	C	S	A	G	I	G	R	T	G	T	V	L	V	L	D	A	L	L	N	Q	V	K	K	V	G	L	L	C	P	M	D	V	Y	K	M	V	K	Y	V	R	T	Y	R	S	G	L	V	Q	T	E	Q	Q	Y	Q	F	L	Y	K	A	L	A	F	Y	L	K	N
Query Conservation
Alig confidence
Template Conservation
Template Sequence		H	C	S	A	G	I	G	R	T	G	T	F	I	V	I	D	I	L	I	D	I	I	R	E	K	G	V	D	C	D	I	D	V	P	K	T	I	Q	M	V	R	S	Q	R	S	G	M	V	Q	T	E	A	Q	Y	R	F	I	Y	M	A	V	Q	H	Y	I	E	T
Template Known Secondary structure				S	S	S	S	S																				T	T	S													T	T	S	T	T		S		S
Template Predicted Secondary structure
Template SS confidence
		458	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.

No model constructed - rank, confidence too low

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D