|   |   |
237 | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
I | E | A | D | L | F | V | D | R | F | E | I | I | R | R | P | I | N | P | R | E | S | M | E | K | T | G | I | S | E | E | F | D | R | L | S | Q | E | A | L | P | A | E | Q | Y | L | S | K | R | E | G | R | R | P | V | N | A | E | K | N | R | Y | K | N | I | V | P | F | D | H | T | R | V | I | L | T | D | R | P | N |
| Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|
|   |   |
|
|
|
|   |
|
|
|
|
|
|   |
|
|
|   |
|   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
| Template Conservation |   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . | . |   |   |   |   |
|   |   |
|
|   |   |
|   |   |   |   |   |   |   |   | . | . | . | . |   |   |   |   |   |   |   |   |
|   |   |
|
|
|   |   |   |
|   |   |   |
|   |   |
|
|   |
|   | . | . | . | . |
| Template Sequence |   |
I | K | I | N | Q | F | E | G | H | F | M | K | L | Q | A | D | . |
. |
. |
. |
. |
. |
. |
S | N | Y | L | L | S | K | E | Y | E | E | L | K | D | V | G | R | N | Q | S | . |
. |
. |
. |
C | D | I | A | L | L | P | E | N | R | G | K | N | R | Y | N | N | I | L | P | Y | D | A | T | R | V | K | L | S | . |
. |
. |
. |
| Template Known Secondary structure |   |
 |  | G | G | G |  |  |  |  |  |  |  |  | T |  |  | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  | T | T | T | T | T | T | T | S |
| . | . | . | . |
| T | T | T | T | S | G | G | G | G | G | G |
| S | S | T | T |
|
| B |
| T | T | T |  |  |  |
|
| . | . | . | . |
| Template Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
| . | . | . | . | . | . | . |
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
| . | . | . | . |  |  |  |  |
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
| . | . | . | . |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1683 | . | . | . | . | . | . | 1690 | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
. | 1700 | . | . | . | . | . | . | . | . | . | 1710 | . | . | . | . | . | . | . | . | |
|
|
|
. | 1720 | . | . | . | . | . | . | . | . | . | 1730 | . | . | . | . | . | . | . | . | . | 1740 | . | . | . | . | . | . | . | |
|
|
|
|   |
|   |   |
317 | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | |
. | . | . | . | . | . | . | . | 390 | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|
| . |
|
|  |  |
|
|
|
|
|
|
|
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
T | P | G | S | D | Y | I | N | A | S | Y | V | R | F | E | N | S | Q | R | T | K | N | V | T | F | A | C | E | K | S | F | I | A | T | Q | G | C | L | E | T | T | I | S | D | F | W | S | M | V | W | Q | E | N | S | R | V | I | V | M | P | T | M | E | N | E | . |
R | K | E | K | C | A | R | Y | W | P | A | E | V | N |
| Query Conservation |   |
  |   |   |
|
|
|
|
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |
|   |
|
|
|
|
|
|
|
|   |   |
|
|   |
|
|
|
|
|
|
|
|
|
|
|   |
|
|
|
|
|
|   |   |   |
| . |   |   |   |
|
|   |   |
|
|
|   |
|   |   |
| Alig confidence |   |
. | . |
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
| . |
|
| Template Conservation |   |
. | . |   |   |
|
|
|
|
|
|   |
|   | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |
|
|   |
|
|   |
|   |   |   |
|   |   |
|
|
|   |
|
|   |   |   |   |   |   |   |
|
|   |
|   |   |   |   |
|   |   |   |   |
|   |   |   |
|
|
|   |   | . |   |
| Template Sequence |   |
. |
. |
N | S | D | Y | I | N | A | S | Y | I | P | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
G | N | N | F | R | R | E | Y | I | V | T | Q | G | P | L | P | G | T | K | D | D | F | W | K | M | V | W | E | Q | N | V | H | N | I | V | M | V | T | Q | C | V | E | K | G | R | V | K | C | D | H | Y | W | P | A | D | . |
Q |
| Template Known Secondary structure |   |
. | . |
|
|
|  |  |  |  |  |  |  |
| . | . | . | . | . | . | . | . | . | . |
| S | S |
| T | T |
|  |  |  |  |
|
|
|
| T | T | T |  |  |  |  |  |  |  |  |  |  | T | T |
|
|  |  |  |  |
| S |
| S |  |  | T | T |  |  |
| S |
|
|
| S |
| S | S | . | S |
| Template Predicted Secondary structure |   |
. | . |
|
|
|  |  |  |  |  |  |
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
| . |
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
|
|
1748 | . | 1750 | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
. | 1760 | . | . | . | . | . | . | . | . | . | 1770 | . | . | . | . | . | . | . | . | . | 1780 | . | . | . | . | . | . | . | . | . | 1790 | . | . | . | . | . | . | . | . | . | 1800 | . | . | . | . | . | . | . | . | . | 1810 | . | . | . | |
. |
|   |
|   |   |
396 | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
K | P | E | V | H | G | D | I | S | L | T | C | T | I | E | R | K | V | Q | R | A | V | S | D | E | V | K | A | E | L | E | Q | E | K | T | N | R | I | A | K | G | L | V | P | E | A | E | L | N | G | D | G | I | S | Y | I | L | R | T | L | V | M | K | K | G | K | D | T | R | E | I | R | Q | L | Q | Y | L | T | W | P |
| Query Conservation |   |
  |   |   |   |   |
|   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |
|   |
|   |   |   |   |   |   |
|   |
|   |
|   |   |
|
|   |
|
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |
|   |
|   |   |   |   | . | . |   |   |   |   |
|   |   |   |   |   |   |   |
|   |
| Template Sequence |   |
D | S | L | Y | Y | G | D | L | I | L | Q | M | L | S | E | S | V | L | P | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
E | W | T | I | R | E | F | K | I | C | G | . |
. |
E | H | R | L | I | R | H | F | H | Y | T | V | W | P |
| Template Known Secondary structure |   |
S |
|  |  |  | T | T |  |  |  |  |  |  |  |  |  |  |
| S | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | S |  |  |  |  |  |  |  |  |  |
| . | . |
|
|  |  |  |  |  |  |  |  |
|
|
|
|
| Template Predicted Secondary structure |   |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|  |  |  |  |  |  |  |  |
|
| . | . |
|
|  |  |  |  |  |  |  |  |  |
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1821 | . | . | . | . | . | . | . | . | 1830 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1840 | . | . | . | . | . | . | . | . | . | 1850 | |
|
. | . | . | . | . | . | . | . | . | 1860 | . | . | . | . |
|   |
|   |   |
476 | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540 | . | . | . | . | . | . | . | . | . | 550 | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
D | H | G | C | P | L | H | P | Y | A | V | L | N | F | L | E | D | V | D | R | E | Y | D | Y | F | N | A | Q | P | I | A | A | S | L | P | Q | G | P | I | V | V | H | C | S | A | G | I | G | R | T | G | T | V | L | V | L | D | A | L | L | N | Q | V | K | K | V | G | L | L | C | P | M | D | V | Y | K | M | V | K | Y |
| Query Conservation |   |
|   |
|
|
|   |   |   |   |   |
|
|   |
|
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |
|
|   |
|
|   |   |   |   |   |   |   |   |
|
|
|   |   |   |
|
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   | . | . | . | . | . | . | . | . |   |   |   |   |   |   |
|
|
|
|
|
|   |   |
|   |
|
|
|
|   |
|   |
|   |   |   |   |   |   |   |
|   |   |   |   | . | . | . |   |
|
|
|   |   |   |
|   |   |
| Template Sequence |   |
D | H | G | V | P | E | T | T | Q | S | L | I | Q | F | V | R | T | V | R | D | Y | I | N | . |
. |
. |
. |
. |
. |
. |
. |
R | S | P | G | A | G | P | T | V | V | H | C | S | A | G | V | G | R | T | G | T | F | I | A | L | D | R | I | L | Q | Q | L | D | S | K | D | . |
. |
. |
S | V | D | I | Y | G | A | V | H | D |
| Template Known Secondary structure |   |
T | T | S |
|
| S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . | . | . | . | . | . | T | S | T | T |
|
|
|  |  |  |  |
| S | S | S | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | T |
| S | . | . | . |  |  |
|  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . | . | . | . | . | . |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| . | . | . |
|
|
|  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1870 | . | . | . | . | . | . | . | . | . | 1880 | . | . | . | . | . | . | . | . | . | 1890 | . | . | |
|
|
|
|
|
|
|
. | . | . | . | . | . | . | 1900 | . | . | . | . | . | . | . | . | . | 1910 | . | . | . | . | . | . | . | . | . | 1920 | . | . | . | . | . | . | . | . | |
|
|
. | 1930 | . | . | . | . | . | . | . | . |
|   |
|   |   |
556 | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
V | R | T | Y | R | S | G | L | V | Q | T | E | Q | Q | Y | Q | F | L | Y | K | A | L | A | F | Y | L | K | N |
| Query Conservation |   |
|
|   |
|
|   |   |
|
|
|
|   |
|
|
|   |
|
|
|   |
|
|   |   |
|
|   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|
|   |
|
|   |   |   |
|   |
|   |   |
|
|   |
|
|
|   |   |
|   |   |   |
|   |   |
| Template Sequence |   |
L | R | L | H | R | V | H | M | V | Q | T | E | C | Q | Y | V | Y | L | H | Q | C | V | R | D | V | L | R | A |
| Template Known Secondary structure |   |
 |  |  |  | B | T | T | S | S |
| S |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1939 | 1940 | . | . | . | . | . | . | . | . | . | 1950 | . | . | . | . | . | . | . | . | . | 1960 | . | . | . | . | . | . |
|   |