Email l.a.kelley@imperial.ac.uk Description Q22070 Date Sat Apr 13 12:57:32 BST 2013 Unique Job ID 810548c15e619017

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3ohmB_ 100.0 37 PDB header:signaling protein / hydrolase Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3 2 c3qr0A_ 100.0 33 PDB header:hydrolase Chain: A: PDB Molecule:phospholipase c-beta (plc-beta); PDBTitle: crystal structure of s. officinalis plc21 3 c2fjuB_ 100.0 37 PDB header:signaling protein,apoptosis/hydrolase Chain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: activated rac1 bound to its effector phospholipase c beta 2 4 c1djyB_ 100.0 46 PDB header:lipid degradation Chain: B: PDB Molecule:phosphoinositide-specific phospholipase c, PDBTitle: phosphoinositide-specific phospholipase c-delta1 from rat2 complexed with inositol-2,4,5-trisphosphate 5 d2zkmx4 100.0 54 Fold:TIM beta/alpha-barrel Superfamily:PLC-like phosphodiesterases Family:Mammalian PLC 6 d1qasa3 100.0 59 Fold:TIM beta/alpha-barrel Superfamily:PLC-like phosphodiesterases Family:Mammalian PLC 7 c3gqiB_ 100.0 32 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 8 c2b3oA_ 100.0 24 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 9 c3ps5A_ 100.0 29 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 10 d2zkmx2 100.0 27 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 11 c2shpA_ 100.0 29 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 12 d1qasa2 100.0 38 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 13 c2lqnA_ 99.9 20 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 14 c4fl2A_ 99.9 27 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 15 c2oq1A_ 99.9 30 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 16 c2eyzA_ 99.9 17 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 17 c2ozoA_ 99.9 28 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 18 c1a81E_ 99.9 26 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 19 d2zkmx1 99.8 17 Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins 20 d1qasa1 99.8 20 Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins 21 d2zkmx3 not modelled 99.8 18 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 22 c2eyyA_ not modelled 99.8 23 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 23 d1djxb1 not modelled 99.8 19 Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins 24 c3h4wA_ not modelled 99.8 23 PDB header:hydrolase Chain: A: PDB Molecule:phosphatidylinositol-specific phospholipase c1; PDBTitle: structure of a ca+2 dependent phosphatidylinositol-specific2 phospholipase c (pi-plc) enzyme from streptomyces antibioticus 25 c2dvjA_ not modelled 99.7 24 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 26 c3qwxX_ not modelled 99.7 22 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 27 c3or8A_ not modelled 99.6 12 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 28 c3qwyA_ not modelled 99.6 22 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 29 c2fjlA_ not modelled 99.6 32 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the split ph domain in phospholipase2 c-gamma1 30 c2xp1A_ not modelled 99.6 20 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 31 d1maia_ not modelled 99.6 17 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Pleckstrin-homology domain (PH domain) 32 c2eobA_ not modelled 99.6 33 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 33 d2nq3a1 not modelled 99.5 21 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 34 c2nq3A_ not modelled 99.5 21 PDB header:ligase Chain: A: PDB Molecule:itchy homolog e3 ubiquitin protein ligase; PDBTitle: crystal structure of the c2 domain of human itchy homolog2 e3 ubiquitin protein ligase 35 c3m7fB_ not modelled 99.5 23 PDB header:signaling protein/ligase Chain: B: PDB Molecule:e3 ubiquitin-protein ligase nedd4; PDBTitle: crystal structure of the nedd4 c2/grb10 sh2 complex 36 d2r83a1 not modelled 99.5 27 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 37 d1gmia_ not modelled 99.5 17 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 38 c2chdA_ not modelled 99.5 27 PDB header:protein transport Chain: A: PDB Molecule:rabphilin-3a; PDBTitle: crystal structure of the c2a domain of rabphilin-3a 39 c3nsjA_ not modelled 99.5 20 PDB header:immune system Chain: A: PDB Molecule:perforin-1; PDBTitle: the x-ray crystal structure of lymphocyte perforin 40 c2q3xA_ not modelled 99.5 19 PDB header:transport protein Chain: A: PDB Molecule:regulating synaptic membrane exocytosis protein 1; PDBTitle: the rim1alpha c2b domain 41 c3l9bA_ not modelled 99.5 17 PDB header:membrane protein Chain: A: PDB Molecule:otoferlin; PDBTitle: crystal structure of rat otoferlin c2a 42 d1rlwa_ not modelled 99.5 24 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 43 d1ugka_ not modelled 99.4 21 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 44 c2dmhA_ not modelled 99.4 19 PDB header:lipid binding protein Chain: A: PDB Molecule:myoferlin; PDBTitle: solution structure of the first c2 domain of human myoferlin 45 c2gsbA_ not modelled 99.4 23 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 46 c2hdxB_ not modelled 99.4 22 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 47 d1dsya_ not modelled 99.4 30 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 48 c2vszA_ not modelled 99.4 17 PDB header:apoptosis Chain: A: PDB Molecule:engulfment and cell motility protein 1; PDBTitle: crystal structure of the elmo1 ph domain 49 c3fbkB_ not modelled 99.4 22 PDB header:signaling protein Chain: B: PDB Molecule:regulator of g-protein signaling 3; PDBTitle: crystal structure of the c2 domain of the human regulator2 of g-protein signaling 3 isoform 6 (rgp3), northeast3 structural genomics consortium target hr5550a 50 d1v27a_ not modelled 99.4 24 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 51 c3kwtA_ not modelled 99.4 26 PDB header:metal binding protein Chain: A: PDB Molecule:munc13-1; PDBTitle: munc13-1 c2b-domain, calcium-free 52 c2fk9A_ not modelled 99.4 18 PDB header:transferase Chain: A: PDB Molecule:protein kinase c, eta type; PDBTitle: human protein kinase c, eta 53 c3hizB_ not modelled 99.4 26 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 54 c2z0uB_ not modelled 99.4 13 PDB header:lipid binding protein Chain: B: PDB Molecule:ww domain-containing protein 1; PDBTitle: crystal structure of c2 domain of kibra protein 55 c2dx0B_ not modelled 99.3 36 PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2 56 c2jqzA_ not modelled 99.3 21 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase smurf2; PDBTitle: solution structure of the c2 domain of human smurf2 57 d2fcia1 not modelled 99.3 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 58 d1bdya_ not modelled 99.3 16 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 59 d2izva2 not modelled 99.3 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 60 c3jzyA_ not modelled 99.3 30 PDB header:endocytosis Chain: A: PDB Molecule:intersectin 2; PDBTitle: crystal structure of human intersectin 2 c2 domain 61 d1a25a_ not modelled 99.3 26 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 62 d3c7ia1 not modelled 99.3 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 63 c2crhA_ not modelled 99.3 23 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 64 c1dqvA_ not modelled 99.3 30 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:synaptotagmin iii; PDBTitle: crystal structure of synaptotagmin iii c2a/c2b 65 c2d8kA_ not modelled 99.3 28 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:synaptotagmin vii; PDBTitle: solution structure of the first c2 domain of synaptotagmin2 vii 66 d1wfma_ not modelled 99.3 16 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 67 c2enpA_ not modelled 99.3 26 PDB header:transport protein Chain: A: PDB Molecule:b/k protein; PDBTitle: solution structure of the first c2 domain from human b/k2 protein 68 d1rsya_ not modelled 99.3 27 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 69 c2y3aB_ not modelled 99.3 30 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 70 c2eo6A_ not modelled 99.2 27 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 71 d2bwqa1 not modelled 99.2 23 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 72 c2dlzA_ not modelled 99.2 27 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 73 d1a81e2 not modelled 99.2 37 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 74 d2oq1a2 not modelled 99.2 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 75 d2ep6a1 not modelled 99.2 30 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 76 d2qmsa1 not modelled 99.2 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 77 d2cjta1 not modelled 99.2 24 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 78 c2nsqA_ not modelled 99.2 22 PDB header:ligase Chain: A: PDB Molecule:e3 ubiquitin-protein ligase nedd4-like protein; PDBTitle: crystal structure of the c2 domain of the human e3 ubiquitin-protein2 ligase nedd4-like protein 79 d2cjsa1 not modelled 99.2 26 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 80 c2r83B_ not modelled 99.2 26 PDB header:endocytosis, exocytosis Chain: B: PDB Molecule:synaptotagmin-1; PDBTitle: crystal structure analysis of human synaptotagmin 1 c2a-c2b 81 d1a81a1 not modelled 99.2 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 82 d2shpa2 not modelled 99.2 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 83 d1blja_ not modelled 99.2 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 d2oq1a1 not modelled 99.2 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 85 c2dlyA_ not modelled 99.2 37 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 86 c2b3rA_ not modelled 99.2 17 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol-4-phosphate 3-kinase c2 domain- PDBTitle: crystal structure of the c2 domain of class ii phosphatidylinositide2 3-kinase c2 87 d1fhsa_ not modelled 99.2 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 88 d2eyva1 not modelled 99.2 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 89 c2dmgA_ not modelled 99.2 22 PDB header:lipid binding protein Chain: A: PDB Molecule:kiaa1228 protein; PDBTitle: solution structure of the third c2 domain of kiaa12282 protein 90 d2cs0a1 not modelled 99.2 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 91 c2augB_ not modelled 99.2 28 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 92 c2eo3A_ not modelled 99.2 30 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 93 d1a81e1 not modelled 99.2 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 94 d1a81a2 not modelled 99.1 36 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 95 d1pica_ not modelled 99.1 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 96 c2ysxA_ not modelled 99.1 33 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 97 c1x6cA_ not modelled 99.1 23 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 98 d1wfja_ not modelled 99.1 20 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 99 d1csya_ not modelled 99.1 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 100 c2cr4A_ not modelled 99.1 25 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 101 d1nrva_ not modelled 99.1 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 102 d1jyra_ not modelled 99.1 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 103 c2enjA_ not modelled 99.1 14 PDB header:transferase Chain: A: PDB Molecule:protein kinase c theta type; PDBTitle: solution sturcture of the c2 domain from human protein2 kinase c theta 104 d1opka2 not modelled 99.1 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 105 c1ka6A_ not modelled 99.1 23 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 106 d1ayaa_ not modelled 99.1 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 107 d1qcfa2 not modelled 99.1 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 108 d1xa6a2 not modelled 99.1 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 109 d1rjaa_ not modelled 99.1 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 110 c1cjyB_ not modelled 99.1 26 PDB header:hydrolase Chain: B: PDB Molecule:protein (cytosolic phospholipase a2); PDBTitle: human cytosolic phospholipase a2 111 d2shpa3 not modelled 99.1 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 112 c2ci8A_ not modelled 99.1 25 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 113 d1rpya_ not modelled 99.1 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 114 c2el8A_ not modelled 99.1 20 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 115 d1w15a_ not modelled 99.1 23 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:Synaptotagmin-like (S variant) 116 c2knoA_ not modelled 99.1 27 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 117 c3fdwA_ not modelled 99.1 22 PDB header:lipid binding protein Chain: A: PDB Molecule:synaptotagmin-like protein 4; PDBTitle: crystal structure of a c2 domain from human synaptotagmin-2 like protein 4 118 c3n5aA_ not modelled 99.0 25 PDB header:protein transport Chain: A: PDB Molecule:synaptotagmin-7; PDBTitle: synaptotagmin-7, c2b-domain, calcium bound 119 c2dcrA_ not modelled 99.0 25 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 120 c2fo0A_ not modelled 99.0 22 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase