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Job DescriptionQ22070
Confidence100.00%DateSat Apr 13 12:57:32 BST 2013
Rank1Aligned Residues708
% Identity37%Templatec3ohmB_
PDB info PDB header:signaling protein / hydrolaseChain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase PDBTitle: crystal structure of activated g alpha q bound to its effector2 phospholipase c beta 3
Resolution2.70 Å
Model Dimensions (Å)X:100.743 Y:94.810 Z:56.404

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   52.......60.........70.........80.........90.........100.........110.........120.........130.
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Query Sequence  KMFAAMEKGHKVCKIAVLKKWDPAYKQLTLDRYSRQIFLTKLELSAVRNKPTILDIRQIREVQTLNYKLNTIKVDDKWKK
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Template Sequence  TVVETLRRGSKFIKWDE. ETSSRNLVTLRVDPNGFFLYW. . . . . TGPNMEVDTLDISSIRDTRTG. . . . . . . RYARLPK.
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T.T

S


TTS
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GGG
GGGT.......TTS



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   17..20.........30... ......40.........50.... .....60.........70..... ....80..
 
   132.......140.........150.. .......160.........170.........180.........190.........200.. ......
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Query Sequence  DREIVNFDSKAILIISYGMGF. ALSYWILLFESEDACKLWSQGLHNLMMDTRDRDSSPHPLRIERFLHKHFL. . SLMSPA
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Template Sequence  DPKIREVLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWSEELFKLAMNILAQNASR. . . . . NTFLRKAYTKLKLQVNQ
Template Known Secondary structure  S


TT
SSGGG
SSSS
T

.....S

T
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   83......90.........100.........110.........120.........130.........140 .........150.......
 
   209210.........220... ......230.........240 .........250.........260.........270.. .......
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Query Sequence  NDAVARKHMKPFVQT. SLQFKVQSDQLQQVTED. . . . . . . QMNSDQFSFASRQLIHVPELFSSRFADLAEKH. ERKGLVV
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Template Sequence  DGRIPVKNILKMFSADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDID. . . . . KILLEIGAKGKPYL
Template Known Secondary structure  TS
TTGGGTTT


STT

GGG

S

.....TT

STT
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   167..170.........180.........190.........200.........210.........220....... ..230.........240.
 
   280.........290..... ....300.........310.........320.........330.........340.........350..
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Query Sequence  TFQNFLRFLDGKQFDE. . . . . . . LASNRTRALEFLNRYFQEDQAYFGDRNEPSMTVFEFCDFLFSRENSLWDPTNEKVTH
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Template Sequence  TLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKY. . . . EPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLST
Template Known Secondary structure  SS
TTS
TTTS



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TT
TSTTS
SS
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S
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   242.......250.........260.........270......... 280.........290.........300.........310.......
 
   353......360.........370.........380.........390.........400... ......410.........420.........430
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Query Sequence  DMSRPLSHYWIASSHNTYLTGDQLRSESSLDCYAQALLMGCRCIELDCWDG. . QKKPGSAEFIDIVIYHGYTMTSKILLR
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Template Sequence  DMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEE. . . . . . . EPFITHGFTMTTEVPLR
Template Known Secondary structure 


S
GGG

BSSTTBSS
SS
B
STT




SSS
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   318.320.........330.........340.........350.........360.........370... ......380.........390
 
   431........440.........450...... ...460.........470.........480... ......490.........500.....
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Query Sequence  DVLHVIRHYAFVTSEYPVILSIEDNC. SVPAQRLLAQELKDILGDYLLTQPANR. . . . EEKQLPSPAALKKKIIVKHKKL
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Template Sequence  DVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKR
Template Known Secondary structure  TTSS

S



TTGGGB

S
BTTB
SSSS




TTTTTT




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   391........400.........410.........420.........430.........440.........450.........460.........470
 
   506...510.........520.........530.........540.........550.........560.........570.........580.....
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Query Sequence  PIESEDLAAVVKTDEFQDTEIISRECVKKGILMVKNNNSHEWTSHVFILFPDRLCYLIQTADPENPNDDTVSVSGDEERE
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Template Conservation          ........................................................................
Template Sequence  HTDEGTAS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure 

TTGGGT........................................................................
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   471.......
 
   586...590.........600.........610.........620.........630.........640.........650.........660.....
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Query Sequence  EETPSGFGVKPEEMHVTEEWFHGRCERDEAKKRILEHKEKGNGLFMIRDSNLFIGDFSLSILHDGKVHHVRIRSKIIDKE
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   666...670.........680.........690.........700.........710.........720.........730.........740.....
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Query Sequence  KKYYFMDNKVCDTLYELVSYYTRHYLTTAHFKMVLTIPCPQPQPHLNQPWFSATADKEKAEELLSLVPEDGAFLIRTSST
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   746...750.........760.........770.........780.........790.........800.........810.........820.....
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Query Sequence  DSSVYVLSLKVDGEFWHYRLKRDGRIFVVNQKVFENLNQIVEFYANREFVRGISLRFPVNEKDISHLTAELAEARTPGCY
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   826...830.........840.........850.........860.........870.........880.........890.........900.....
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Query Sequence  MDLKDLDKEVQARALRPYRGTADDELSFPANVIITVLRKEEGLWRGRYGSLTGWFPSAHVQEILPEKVSTSETSNYNTIE
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   906...910.........920.........930.........940.........950.........960.........970.........980.....
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Query Sequence  LAGTLIERIHDADRPNVIRISQSNQHWMNKQYYLLAASSSEEADGWQNNLFELTRSVNTKMSILRTKEKEKRIAAELSNL
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Template Conservation  ....................................................................        

 
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . SEVNATEEMSTL
Template Known Secondary structure  ....................................................................T




TT
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   582.......590...
 
   986...990..... ....1000.........1010.........1020. ........1030.........1040.........1050.........1060
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Query Sequence  VVYCQAVPFD. . PAHIYNDAFYEMCSFVEGKLDKLVEK. . . GLLPFNSRKLSRVYPNGSRITSNNYSPVPMWNAGCHMVA
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Template Sequence  VNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVA
Template Known Secondary structure 
SS





T
TTSS


TT
TT




TTTT
S
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   594.....600.........610.........620.........630.........640.........650.........660.........670...
 
   1061........1070.........1080.........1090...... ...1100.........1110.........1120.........1130........
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Query Sequence  LNYQTGDKPMQLNQGKFLANGRCGYLLKPDYMLTDD. . FDPTNTEKFATAYPIRLNVQVIGGRHLSRKDKNKGICSPFVE
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Template Sequence  LNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRK. . . . . VGIYVE
Template Known Secondary structure  B
TT

STTGGG
S

GGGT
TT



TT
SS

TT


S

SS
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   674.....680.........690.........700.........710.........720.........730.........740.. ......
 
   11391140........ .1150.........1160........ .1170. ........1180.........1190.........1200.........1210.....
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Query Sequence  IEIIGMPCDT. KVFQTKTIASNGLNPIWNQT. FTF. EIQCPEVALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRS
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Template Sequence  VDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEG. . . . . . GKFVGHRILPVSAIRSGYHY
Template Known Secondary structure  SSTTT
B







SS
SSS
B




S
GGG
TT......TTTT


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   749750.........760.........770.........780.........790.........800.. .......810.........820..
 
   1216...1220.........1230.........1240... ......1250.. .......1260.....
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Query Sequence  VPLKNQYSEELELSSLLVDVQMCSREGT. . . . . . QLIRSSSHF. LQASRLAPVFAHR
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Template Sequence  VCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAAL
Template Known Secondary structure 
TTS



GGG
T
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   823......830.........840.........850.........860.........870.........
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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