|   |   |
598 | . | 600 | . | . | . | . | . | . | . | . | . | 610 | . | . | . | . | . | . | . | . | . | 620 | . | . | . | . | . | . | . | . | . | 630 | . | . | . | . | . | . | . | . | . | 640 | . | . | . | . | . | . | . | . | . | 650 | . | . | . | . | . | . | . | . | . | 660 | . | . | . | . | . | . | . | . | . | 670 | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
E | M | H | V | T | E | E | W | F | H | G | R | C | E | R | D | E | A | K | K | R | I | L | E | H | K | E | K | G | N | G | L | F | M | I | R | D | S | N | L | F | I | G | D | F | S | L | S | I | L | H | D | G | K | V | H | H | V | R | I | R | S | K | I | I | D | K | E | K | K | Y | Y | F | M | D | N | K | V | C | D |
| Query Conservation |   |
|   |   |   |   |
|   |
|
|
|
|
|
|
|
|   |   |
|
|   |
|
|
|
|   |   |   |   |
|   |   |
|   |
|
|
|
|
|   |   |
|   |
|
|   |
|
|
|
|   |   |   |   |   |
|   |
|   |
|
|
|
|   |   |   |   |
|   |   |
|   |   |
|   |   |
|   |   |
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |
|   |   |   |   |   |   |
|   |   |
|   |   |   |
|   | . | . | . |   |   |   |   |
|   |
|
|
|
|   |
|   |   |   |   |   |   |   |   |
|
|
|   |   |   |   |   |   |   |
|   |   |
|   |   |   |   |   |   | . | . | . | . |   |   |   |   |   |   |   |   |
|   |
| Template Sequence |   |
D | S | S | D | R | S | A | W | Y | M | G | P | V | S | R | Q | E | A | Q | T | R | L | Q | . |
. |
. |
G | Q | R | H | G | M | F | L | V | R | D | S | S | T | C | P | G | D | Y | V | L | S | V | S | E | N | S | R | V | S | H | Y | I | I | N | S | L | P | N | R | . |
. |
. |
. |
R | F | K | I | G | D | Q | E | F | D |
| Template Known Secondary structure |   |
| S | S |
|  |  |  |  |  |  |  | S |
|  |  |  |  |  |  |  |  | S | S | . | . | . | S | T | T | S | S |  |  |  |  |  |  |
| S | S | S | T | T |
|  |  |  |  |  |  | S | T | T |
|
|  |  |  |  |  |  |  |  | T | T | T | . | . | . | . |  |  |  |  | T | T |  |  |  | S |
| Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  | . | . | . |
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |
|
|
|
| . | . | . | . |  |  |  |  |
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
7 | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | |
|
|
30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | . | . | . | . | . | . | . | . | . | |
|
|
|
70 | . | . | . | . | . | . | . | . | . |
|   |
|   |   |
678 | . | 680 | . | . | . | . | . | . | . | . | . | 690 | . | . | . | . | . | . | . | . | . | 700 | . | . | . | . | . | . | . | . | . | 710 | . | . | . | . | . | . | . | . | . | 720 | . | . | . | . | . | . | . | . | . | 730 | . | . | . | . | . | . | . | . | . | 740 | . | . | . | . | . | . | . | . | . | 750 | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
T | L | Y | E | L | V | S | Y | Y | T | R | H | Y | L | T | T | A | H | F | K | M | V | L | T | I | P | C | P | Q | P | Q | P | H | L | N | Q | P | W | F | S | A | T | A | D | K | E | K | A | E | E | L | L | S | L | V | P | E | D | G | A | F | L | I | R | T | S | S | T | D | S | S | V | Y | V | L | S | L | K | V | D |
| Query Conservation |   |
|
|   |
|
|
|   |   |
|
|
|   |   |
|
|   |   |   |   |
|   |   |
|
|
|
|
|
|
|
|   |   |
|   |
|
|   |
|
|   |   |   |   |
|
|   |   |
|
|   |   |
|   |
|
|   |
|
|
|
|
|
|
|
|   |
|   |   |   |   |
|
|   |
|
|
|
|
|   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|
|   |   |
|
|   |   |
|   |   |   |   |
|   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|
|   |
|   |   |   |
|
|
|
|
|   |
|
|
| . | . |
|
|   |
|
|   |   |   |
|
| Template Sequence |   |
H | L | P | A | L | L | E | F | Y | K | I | H | Y | L | D | T | T | T | L | I | E | P | A | P | R | Y | P | S | P | P | M | G | S | V | S | A | P | N | L | P | T | A | E | D | N | L | E | Y | V | R | T | L | Y | D | F | P | G | N | D | A | E | D | L | P | F | K | K | G | E | . |
. |
I | L | V | I | I | E | K | P | E |
| Template Known Secondary structure |   |
S |  |  |  |  |  |  |  | T | T | T | T |
| S | S | S | S |
|
|
|  |  |
|
| S | S |
|
|
|
| S | S |
|
|
|
| S | S |
| S | S | S | S | S | S | S | S |  |  |  |  | S | S |
| B |
|
|
| S | S | S | B |
|
| B |
| S | S |  | . | . |  |  |  |  |  |  |
|
| S |
| Template Predicted Secondary structure |   |
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |  |  |  |  |  |
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | |
|
. | 150 | . | . | . | . | . | . | . |
|   |
|   |   |
758 | . | 760 | . | . | . | . | . | . | . | . | . | 770 | . | . | . | . | . | . | . | . | . | 780 | . | . | . | . | . | . | . | . | . | 790 | . | . | . | |
|
|
|
|
|
. | . | . | . | . | . | 800 | . | . | . | . | . | . | . | . | . | 810 | . | . | . | . | . | . | . | . | . | 820 | . | . | . | . | . | . | . | . | . | 830 | . |
| Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
G | E | F | W | H | Y | R | L | K | R | D | G | R | I | F | V | V | N | Q | K | V | F | E | N | L | N | Q | I | V | E | F | Y | A | N | R | E | . |
. |
. |
. |
. |
. |
F | V | R | G | I | S | L | R | F | P | V | N | E | K | D | I | S | H | L | T | A | E | L | A | E | A | R | T | P | G | C | Y | M | D | L | K | D | L |
| Query Conservation |   |
  |   |
|
|
|   |   |
|   |   |
|
|
|   |   |   |
|
|
|   |   |
|   |
|
|   |
|
|
|
|
|
|   |   |   |
| . | . | . | . | . | . |
|   |
|   |   |   |
|   |   |
|
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |
|
|   |   |   |   | . |   |   |
|   |   |
|   |
|
|   |
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
E | Q | W | W | S | A | R | N | . |
K | D | G | R | V | G | M | I | P | V | P | Y | V | E | K | L | V | R | S | S | P | H | G | K | H | G | N | R | N | S | N | S | Y | G | I | P | E | P | A | H | A | Y | A | Q | P | Q | T | T | T | P | L | P | A | V | S | G | S | P | G | A | A | I | T | P | L | P | S | T | Q | N | G |
| Template Known Secondary structure |   |
S | S |  |  |  |  |  |
| . | S | S |
|
|  |  |  |  |  | G | G | G |  |  |  | S | S |
|
|
|
|
| S | S | T | T |
|
|
|
| S | S |
|
|
|
|
| G | G | G | T | T |
|
|
|
|
|
|
|
|
|
|
|
|
|
| S |
|
|
|
|
| S |
|
|
| S |
|
|
|
|
| Template Predicted Secondary structure |   |
|
|  |  |  |  |  |
| . |
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
158 | . | 160 | . | . | . | . | . | |
. | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . |
|   |
|   |   |
832 | . | . | . | . | . | . | . | 840 | . | . | . | . | . | . | . | . | . | 850 | . | . | . | . | . | . | . | . | . | 860 | . | . | . | . | |
. | . | . | . | . | 870 | . | . | . | . | . | . | . | . | . | 880 | . | . | . | . | . | . | . | . | . | 890 | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
D | K | E | V | Q | A | R | A | L | R | P | Y | R | G | T | A | D | D | E | L | S | F | P | A | N | V | I | I | T | V | L | R | K | . |
E | E | G | L | W | R | G | R | Y | G | S | L | T | G | W | F | P | S | A | H | V | Q | E | I | L | P | E | K | V | S | T | S | E |
| Query Conservation |   |
  |   |   |   |   |   |
|
|   |   |
|   |   |
|   |   |   |
|
|
|
|
|   |
|   |
|
|
|   |   |
|   |
| . |   |   |   |   |
|
|
|   |   |
|   |   |   |   |   |
|
|   |
|   |
|   |
|   |   |   |   |   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |
|   |   |   |
|   |   |   |
|   |   |   |   |
|
|
|
|   |   |
|
|
|
|   |
|
|   |   |   |
|   |
|
|
|   |
|   |   |   |
|   |   |
|   |
|
|   |
|
|
|
|   |
|   |   |   |   |   |   |   |   |
|
| Template Sequence |   |
P | V | F | A | K | A | I | Q | K | R | V | P | C | A | Y | D | K | T | A | L | A | L | E | V | G | D | I | V | K | V | T | R | M | N | I | N | G | Q | W | E | G | E | V | N | G | R | K | G | L | F | P | F | T | H | V | K | I | F | D | P | Q | N | P | D | E | N | E |
| Template Known Secondary structure |   |
|  |  |  |  |  |
| S |
| B |
|
|
| T | T |
| S | S | B |
|
| B |
| T | T |  |  |  |  |  |  |  |
|
| T | T | S |  |  |  |  |  |
| S | S |
|  |  |  |  |  |
| T | T |  |  |  |  |
| S | S | S | S | T | T |
|
|
| Template Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|  |  |  |  |  |  |
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
237 | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . |
|   |