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Job DescriptionQ22070
Confidence100.00%DateSat Apr 13 12:57:32 BST 2013
Rank3Aligned Residues661
% Identity37%Templatec2fjuB_
PDB info PDB header:signaling protein,apoptosis/hydrolaseChain: B: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: activated rac1 bound to its effector phospholipase c beta 2
Resolution2.20 Å
Model Dimensions (Å)X:90.133 Y:85.197 Z:58.793

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   52.......60.........70.........80.........90.........100.........110.........120.........130.
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Query Sequence  KMFAAMEKGHKVCKIAVLKKWDPAYKQLTLDRYSRQIFLTKLELSAVRNKPTILDIRQIREVQTLNYKLNTIKVDDKWKK
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Template Sequence  KVKAYLSQGERFIKWDD. ETTVASPVILRVDPKGYYLYWTY. . . . . QSKEMEFLDITSIRDTRFG. . . . . . . KFAKMPKS
Template Known Secondary structure 



SS.SSS

TTS
.....TTS
GGGG.......GGS



S
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   12.......20........ .30.........40.........50. ........60.........70 ........
 
   132. ......140.........150.. .......160.........170.........180.........190.........200..
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Query Sequence  DR. . . . . . . . EIVNFDSKAILIISYGMGF. ALSYWILLFESEDACKLWSQGLHNLMMDTRDRDSSPHPLRIERFLHKHFL
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Template Sequence  QKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKM.
Template Known Secondary structure  TTTTSTT

GGGT
SSSSS
SSSST
T

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   7980.........90.........100.........110.........120.........130.........140.........150.......
 
   203......210.........220...... ...230.........240 .........250.........260.........270...
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Query Sequence  SLMSPANDAVARKHMKPFVQTSLQ. . FKVQSDQLQQVTED. . . . . . . QMNSDQFSFASRQLIHVPELFSSRFADLAEKHE
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Template Sequence  . . QLNSEGKIPVKNFFQMFP. ADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEID. . . . . EIFTSY.
Template Known Secondary structure  ..S

TTS
ST.T
TT


SSS

GGGS
TTS

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   158.160.........170..... ....180.........190.........200.........210.........220.. ......
 
   274.....280.........290.........300.........310.........320.........330.........340.........350...
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Query Sequence  RKGLVVTFQNFLRFLDGKQFDELASNRTRALEFLNRYFQEDQAYFGDRNEPSMTVFEFCDFLFSRENSLWDPTNEKVTHD
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Template Sequence  . . . . . MTKEHLTKFINQKQRDQ. . . . . . . . . GLIDKY. . . . EPS. . . . . . GQLSPEGMVWFLCGPENSVLAQDKLLLHHD
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BTS


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B

STTS
SB
GGGGSS
S
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   236...240.........250.. ...... .260. ........270.........280.........290.
 
   354.....360.........370.........380.........390.........400... ......410.........420.........430.
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Query Sequence  MSRPLSHYWIASSHNTYLTGDQLRSESSLDCYAQALLMGCRCIELDCWDG. . QKKPGSAEFIDIVIYHGYTMTSKILLRD
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Template Sequence  MTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDE. . . . . . . EPIITHGFTMTTDIFFKE
Template Known Secondary structure 

S
GGG
BBSSTTBSS
SSSS
B
TTT




TTTT.......



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   314.....320.........330.........340.........350.........360........ .370.........380......
 
   432.......440.........450...... ...460.........470.........480... ......490.........500......
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Query Sequence  VLHVIRHYAFVTSEYPVILSIEDNC. SVPAQRLLAQELKDILGDYLLTQPANR. . . . EEKQLPSPAALKKKIIVKHKKLP
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Template Sequence  AIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKEE
Template Known Secondary structure  TTTS

S




GGGB

S

TTS
SSTT




TTTTTT





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   387..390.........400.........410.........420.........430.........440.........450.........460......
 
   507..510.........520.........530.........540.........550.........560.........570.........580......
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Query Sequence  IESEDLAAVVKTDEFQDTEIISRECVKKGILMVKNNNSHEWTSHVFILFPDRLCYLIQTADPENPNDDTVSVSGDEEREE
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Template Conservation        ..........................................................................
Template Sequence  SGNLDE. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure 




T..........................................................................
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   514.....
 
   587..590.........600.........610.........620.........630.........640.........650.........660......
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Query Sequence  ETPSGFGVKPEEMHVTEEWFHGRCERDEAKKRILEHKEKGNGLFMIRDSNLFIGDFSLSILHDGKVHHVRIRSKIIDKEK
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   667..670.........680.........690.........700.........710.........720.........730.........740......
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Query Sequence  KYYFMDNKVCDTLYELVSYYTRHYLTTAHFKMVLTIPCPQPQPHLNQPWFSATADKEKAEELLSLVPEDGAFLIRTSSTD
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   747..750.........760.........770.........780.........790.........800.........810.........820......
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Query Sequence  SSVYVLSLKVDGEFWHYRLKRDGRIFVVNQKVFENLNQIVEFYANREFVRGISLRFPVNEKDISHLTAELAEARTPGCYM
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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   827..830.........840.........850.........860.........870.........880.........890.........900......
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Query Sequence  DLKDLDKEVQARALRPYRGTADDELSFPANVIITVLRKEEGLWRGRYGSLTGWFPSAHVQEILPEKVSTSETSNYNTIEL
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Template Conservation  ................................................................................
Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Template Known Secondary structure  ................................................................................
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   907..910.........920.........930.........940.........950.........960.........970.........980......
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Query Sequence  AGTLIERIHDADRPNVIRISQSNQHWMNKQYYLLAASSSEEADGWQNNLFELTRSVNTKMSILRTKEKEKRIAAELSNLV
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Template Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EEIKKMQSDEGTAGLEVTAYEEMSSLV
Template Known Secondary structure  .....................................................TTTTTTTTTTGGGG





TT
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   520.........530.........540......
 
   987..990..... ....1000.........1010.........1020. ........1030.........1040.........1050.........1060.
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Query Sequence  VYCQAVPFD. . PAHIYNDAFYEMCSFVEGKLDKLVEK. . . GLLPFNSRKLSRVYPNGSRITSNNYSPVPMWNAGCHMVAL
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Template Sequence  NYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL
Template Known Secondary structure  SS





T
TTS

TT
TT





TT


B
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   547..550.........560.........570.........580.........590.........600.........610.........620......
 
   1062.......1070.........1080.........1090.........1100.........1110.........1120.........1130.........1140.
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Query Sequence  NYQTGDKPMQLNQGKFLANGRCGYLLKPDYMLTDDFDPTNTEKFATAYPIRLNVQVIGGRHLSRKDKNKGICSPFVEIEI
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Template Sequence  NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRR. . . . . . . . . . . . . . . PTTLSITVISGQFLSERS. . . . . VRTYVEVEL
Template Known Secondary structure 
TT

STTTGGG
S

GGGT
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S

SS
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   627..630.........640.........650......... 660.........670....... ..680......
 
   1142...... .1150.........1160...... ...1170.. .......1180.........1190.........1200.........1210.......
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Query Sequence  IGMPCDT. . KVFQTKTIASNGLNPIWN. QTFTFE. IQCPEVALIRFHVEDGDFVGPKTDPFIGQAVFPVDSIRCGFRSVP
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Template Sequence  FGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEG. . . . . . NKFLGHRIIPINALNSGYHHLC
Template Known Secondary structure 

TTS







SSS

SS
B







S
GGG
TT......TGGGB

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   704.....710.........720.........730.........740.........750..... ....760.........770.......
 
   1218.1220.........1230.........
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Query Sequence  LKNQYSEELELSSLLVDVQMCS
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Template Sequence  LHSESNMPLTMPALFIFLEMKD
Template Known Secondary structure 
TT


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   778.780.........790.........
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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