Email l.a.kelley@imperial.ac.uk Description Q967F3 Date Sat Apr 13 13:12:35 BST 2013 Unique Job ID 801295d60fd67ab0

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2knoA_ 99.9 22 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 2 d1wj1a_ 99.9 16 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 3 d1oy2a_ 99.8 20 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 4 d1lkka_ 99.8 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 5 c3so6A_ 99.8 16 PDB header:protein binding/protein transport Chain: A: PDB Molecule:ldl receptor adaptor protein; PDBTitle: crystal structure of the ldl receptor tail in complex with autosomal2 recessive hypercholesterolemia ptb domain 6 d1g83a2 99.8 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 7 d1cwea_ 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 8 d1opka2 99.8 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 9 c2c9wA_ 99.8 22 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 10 d2oq1a1 99.8 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 11 c2lctA_ 99.8 22 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 12 c2oq1A_ 99.8 20 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 13 c2dlyA_ 99.8 29 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 14 d1ddma_ 99.8 16 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 15 d1luia_ 99.8 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 16 c2vifA_ 99.8 19 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 17 d1a81a1 99.8 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 18 c2y3aB_ 99.8 26 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 19 c2ekxA_ 99.8 21 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain 20 d2qmsa1 99.8 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 21 d1o48a_ not modelled 99.8 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 22 d2oq1a2 not modelled 99.8 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 23 c1ka6A_ not modelled 99.8 17 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 24 d1blja_ not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 25 c2m38A_ 99.8 22 PDB header:peptide binding protein Chain: A: PDB Molecule:ankyrin repeat and sterile alpha motif domain-containing PDBTitle: ptb domain of aida1 26 d1qcfa2 not modelled 99.8 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 27 d1a81e1 not modelled 99.8 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 28 c2dyqA_ 99.8 18 PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member PDBTitle: crystal structure of the c-terminal phophotyrosine interaction domain2 of human apbb3 29 d1bkla_ not modelled 99.8 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 30 d1f2fa_ not modelled 99.8 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 31 d1a81a2 not modelled 99.8 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 32 d1aqca_ not modelled 99.7 21 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 33 d2eyva1 not modelled 99.7 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 34 c3dxeC_ not modelled 99.7 17 PDB header:protein binding Chain: C: PDB Molecule:amyloid beta a4 protein-binding family b member PDBTitle: crystal structure of the intracellular domain of human app2 (t668a mutant) in complex with fe65-ptb2 35 c3sv1C_ not modelled 99.7 22 PDB header:protein binding Chain: C: PDB Molecule:amyloid beta a4 precursor protein-binding family a member PDBTitle: crystal structure of app peptide bound rat mint2 parm 36 c2ge9A_ not modelled 99.7 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 37 d1d4ta_ not modelled 99.7 17 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 38 d1jwoa_ not modelled 99.7 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 39 c2augB_ not modelled 99.7 24 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 40 c4fl2A_ not modelled 99.7 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 41 d1nrva_ not modelled 99.7 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 42 c2ysxA_ not modelled 99.7 25 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 43 d1k9aa2 not modelled 99.7 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 44 c2gsbA_ not modelled 99.7 15 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 45 d1csya_ not modelled 99.7 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 46 d1i3za_ not modelled 99.7 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 47 d1a81e2 not modelled 99.7 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 48 d2izva2 not modelled 99.7 21 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 49 d1p3ra_ not modelled 99.7 17 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 50 c2izvA_ not modelled 99.7 22 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 51 c2ablA_ not modelled 99.7 29 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 52 c2elaB_ not modelled 99.7 16 PDB header:cell cycle Chain: B: PDB Molecule:adapter protein containing ph domain, ptb domain PDBTitle: crystal structure of the ptb domain of human appl1 53 c2crhA_ not modelled 99.7 21 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 54 c2eo3A_ not modelled 99.7 23 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 55 d1rjaa_ not modelled 99.7 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 56 d2c9wa2 not modelled 99.7 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 57 c2dlzA_ not modelled 99.7 16 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 58 c2hmhA_ not modelled 99.7 22 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 59 c2eo6A_ not modelled 99.7 16 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 60 c2hdxB_ not modelled 99.7 21 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 61 d1pica_ not modelled 99.7 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 62 d1r1qa_ not modelled 99.7 17 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 63 c1a81E_ not modelled 99.7 23 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 64 c1x27F_ not modelled 99.7 23 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 65 c2yszA_ not modelled 99.7 23 PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family PDBTitle: solution structure of the chimera of the c-terminal pid2 domain of fe65l and the c-terminal tail peptide of app 66 c3hizB_ not modelled 99.7 14 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 67 c2ozoA_ not modelled 99.7 20 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 68 c2fo0A_ not modelled 99.7 28 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 69 c3suzA_ not modelled 99.7 22 PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family a member PDBTitle: crystal structure of rat mint2 ppc 70 d1ntva_ not modelled 99.7 19 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 71 c2eobA_ not modelled 99.7 19 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 72 c1g83A_ not modelled 99.7 25 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 73 c3nhnA_ not modelled 99.7 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 74 c2el8A_ not modelled 99.7 13 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 75 c1y57A_ not modelled 99.7 22 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 76 c2h8hA_ not modelled 99.7 21 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 77 d2shpa2 not modelled 99.7 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 78 d2cs0a1 not modelled 99.7 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 79 d3c7ia1 not modelled 99.7 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 80 c2lqnA_ not modelled 99.7 23 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 81 d1ayaa_ not modelled 99.6 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 82 d1fhsa_ not modelled 99.6 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 83 d1mila_ not modelled 99.6 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 d2shpa3 not modelled 99.6 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 85 c2shpA_ not modelled 99.6 21 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 86 d1qada_ not modelled 99.6 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 87 c2dm0A_ not modelled 99.6 22 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk 88 c2ci8A_ not modelled 99.6 22 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 89 c3gqiB_ not modelled 99.6 19 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 90 c1k9aB_ not modelled 99.6 20 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 91 c2kk6A_ not modelled 99.6 19 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 92 c1x6cA_ not modelled 99.6 14 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 93 d2fcia1 not modelled 99.6 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 94 d1rpya_ not modelled 99.6 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 95 d1jyra_ not modelled 99.6 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 96 c1oplA_ not modelled 99.6 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 97 d1fu6a_ not modelled 99.6 15 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 98 c3mazA_ not modelled 99.6 17 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 99 c2c0iA_ not modelled 99.6 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 100 c2dcrA_ not modelled 99.6 19 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 101 c1rqqC_ not modelled 99.6 23 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 102 c2yt1A_ not modelled 99.5 23 PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 protein and amyloid beta a4 PDBTitle: solution structure of the chimera of the c-terminal tail2 peptide of app and the c-terminal pid domain of fe65l 103 c2b3oA_ not modelled 99.5 14 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 104 c3gxxB_ not modelled 99.5 19 PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b 105 d1wgua_ not modelled 99.5 24 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 106 c3ps5A_ 99.5 13 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 107 d2cy5a1 not modelled 99.5 21 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 108 d2dkqa1 not modelled 99.5 21 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 109 c3d8dA_ not modelled 99.4 17 PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member PDBTitle: crystal structure of the human fe65-ptb1 domain 110 d1wvha1 not modelled 99.4 21 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 111 c2eyzA_ not modelled 99.4 23 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 112 d1xa6a2 not modelled 99.4 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 113 c2dvjA_ not modelled 99.4 24 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 114 c3qwxX_ not modelled 99.4 21 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 115 c3qwyA_ not modelled 99.4 21 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 116 c2eyyA_ not modelled 99.4 25 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 117 c3or8A_ not modelled 99.2 21 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 118 d1uura3 not modelled 99.2 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 119 c2cr4A_ not modelled 99.2 26 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 120 c2xp1A_ not modelled 99.1 19 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6