Job Description Q45FX5 Confidence 100.00% Date Fri May 3 21:26:37 BST 2013 Rank 13 Aligned Residues 341 % Identity 19% Template c1x86A_ PDB info PDB header:signaling protein/membrane protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 12; PDBTitle: crystal structure of the dh/ph domains of leukemia-associated rhogef2 in complex with rhoa Resolution 3.22 Å Model Dimensions (Å) X: Y: Z:

Show / Hide SS confidence

Show / Hide Conservation and Alignment quality

		222	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.			.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																																																						.	.
Query SS confidence																																																						.	.
Query Sequence		T	N	R	K	P	S	M	N	E	N	D	L	Q	N	T	P	T	L	K	R	N	R	C	I	R	E	L	Y	D	T	E	K	N	Y	V	A	Q	A	L	V	T	I	I	K	T	F	Y	E	P	L	K	G	.	.	I	I	P	T	S	D	Y	N	I	I	F	G	N	I	E	E	I	N	V	L	H	T	A	L	L	A
Query Conservation																																																						.	.
Alig confidence																																							.															.	.
Template Conservation																																							.
Template Sequence		W	Q	Q	L	V	S	R	E	V	L	L	G	L	K	P	C	E	I	K	R	Q	E	V	I	N	E	L	F	Y	T	E	R	A	H	V	R	T	.	L	K	V	L	D	Q	V	F	Y	Q	R	V	S	R	E	G	I	L	S	P	S	E	L	R	K	I	F	S	N	L	E	D	I	L	Q	L	H	I	G	L	N	E
Template Known Secondary structure		G	G	G	T	S						T	T	S		T	T																						.								T								S		S										T	T
Template Predicted Secondary structure																																							.
Template SS confidence
		769	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.		.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840	.	.	.	.	.	.	.
		300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.							.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.
Predicted Secondary structure																																									.	.	.	.	.	.
Query SS confidence																																									.	.	.	.	.	.
Query Sequence		D	L	E	Y	P	V	K	V	A	L	G	L	S	D	A	T	P	P	R	P	I	S	L	N	E	C	V	P	Q	T	I	G	E	V	F	I	K	Y	R	.	.	.	.	.	.	D	Q	F	L	A	Y	G	K	Y	C	S	N	L	P	D	S	R	K	L	S	N	E	L	L	K	T	N	E	F	I	S	R	N	I	N
Query Conservation																																									.	.	.	.	.	.
Alig confidence												.	.	.	.	.	.	.	.	.	.	.	.	.	.																.	.	.	.	.	.
Template Conservation												.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		Q	M	K	A	V	R	K	R	N	E	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	S	V	I	D	Q	I	G	E	D	L	L	T	W	F	S	G	P	G	E	E	K	L	K	H	A	A	A	T	F	C	S	N	Q	P	F	A	L	E	M	I	K	S	R	Q	K	K	D	S	R	F	Q	T	F	V	Q
Template Known Secondary structure											S	.	.	.	.	.	.	.	.	.	.	.	.	.	.	S	S	S													S																	T
Template Predicted Secondary structure												.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		848	.	850	.	.	.	.	.	.	.															.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910	.	.	.
		374	.	.	.	.	.	380	.		.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.
Predicted Secondary structure										.
Query SS confidence										.
Query Sequence		E	L	T	A	Q	G	N	C	.	K	F	G	M	N	D	L	L	C	V	P	F	Q	R	L	T	K	Y	P	L	L	L	K	E	L	Q	K	K	T	D	L	A	S	P	D	R	K	S	L	E	E	A	V	E	V	M	E	D	V	C	N	Y	I	N	E	E	S	R	D	T	N	A	I	K	V	I	D	E	I	E	Q
Query Conservation										.
Alig confidence										.																																.
Template Conservation																																										.
Template Sequence		D	A	E	S	N	P	L	C	R	R	L	Q	L	K	D	I	I	P	T	Q	M	Q	R	L	T	K	Y	P	L	L	L	D	N	I	A	K	Y	T	E	W	.	P	T	E	R	E	K	V	K	K	A	A	D	H	C	R	Q	I	L	N	F	V	N	Q	A	V	K	E	A	E	N	K	Q	R	L	E	D	Y	Q	R
Template Known Secondary structure					T	S	G	G	G	T	T							T	T																			T				.
Template Predicted Secondary structure																																										.
Template SS confidence
		914	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.		.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.
		453	.	.	.	.	.	.	460	.	.	.	.										.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.
Predicted Secondary structure														.	.	.	.	.	.	.	.	.
Query SS confidence														.	.	.	.	.	.	.	.	.
Query Sequence		S	I	T	D	L	S	M	P	L	N	V	K	.	.	.	.	.	.	.	.	.	L	H	D	Y	G	R	V	N	L	D	G	E	V	K	M	A	E	S	T	L	T	Q	A	G	K	P	K	Q	R	Y	I	F	L	F	D	K	V	I	V	V	C	K	A	A	N	K	V	M	A	A	K	T	T	G	A	S	A	R	T
Query Conservation														.	.	.	.	.	.	.	.	.
Alig confidence														.	.	.	.	.	.	.	.	.																			.	.	.	.																															.	.	.	.	.	.	.
Template Conservation																																									.	.	.	.																															.	.	.	.	.	.	.
Template Sequence		R	L	D	T	S	S	L	K	L	S	E	Y	P	N	V	E	E	L	R	N	L	D	L	T	K	R	K	M	I	H	E	G	P	L	V	W	K	V	N	.	.	.	.	R	D	K	T	I	D	L	Y	T	L	L	L	E	D	I	L	V	L	L	Q	K	Q	D	D	R	L	V	L	R	C	.	.	.	.	.	.	.
Template Known Secondary structure		T				S	S			S	S	S		G	G	G					S			G	G	G	S												S		.	.	.	.	T	T											S	S							B		S	S							.	.	.	.	.	.	.
Template Predicted Secondary structure																																									.	.	.	.																															.	.	.	.	.	.	.
Template SS confidence
		993	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.					.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.
		524	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		N	T	F	T	Y	K	N	A	Y	V	M	S	E	L	T	I	D	K	N	A	S	L	D	V	K	S	G	G	T	I	T	R	R	T	Q	Y	V	I	I	M	T	R	D	R	N	E	N	N	E	I	T	Q	L	T	F	Y	F	K	N	E	A	T	R	N	N	W	M	T	A	L	L	L	S	K	S	N	V	S	P	T
Query Conservation
Alig confidence		.																							.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation		.																							.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		.	H	S	T	F	S	P	V	I	K	L	S	T	V	L	V	R	Q	V	A	T	D	N	.	.	.	.	.	.	.	.	.	.	.	.	.	.	K	A	L	F	V	I	S	M	S	D	N	G	A	Q	I	Y	E	L	V	A	Q	T	V	S	E	K	T	V	W	Q	D	L	I	C	R	M	A	A	S	V	K	E	Q
Template Known Secondary structure		.						S				T	T	S							S	S	S	T	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T							B		S	S		B								S	S																				T
Template Predicted Secondary structure		.																							.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
			1062	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080	.	.	.															.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.
		604
Predicted Secondary structure
Query SS confidence
Query Sequence		D
Query Conservation
Alig confidence
Template Conservation
Template Sequence		S
Template Known Secondary structure
Template Predicted Secondary structure
Template SS confidence
		1138

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D