|   |   |
1925 | . | . | . | . | 1930 | . | . | . | . | . | . | . | . | . | 1940 | . | . | . | . | . | . | . | . | . | 1950 | . | . | . | . | . | . | . | . | . | 1960 | . | . | . | . | . | . | . | . | . | 1970 | . | . | . | . | . | . | . | . | . | 1980 | . | . | . | . | . | . | . | . | . | 1990 | . | . | . | . | . | . | . | . | . | 2000 | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
E | I | E | S | M | A | E | G | R | L | A | K | L | R | D | N | S | A | Y | L | Q | F | M | W | K | C | D | V | V | E | S | W | I | A | E | K | E | Q | Q | V | R | S | E | D | F | G | R | D | L | S | S | V | Q | I | L | L | T | K | Q | E | A | F | D | A | G | L | N | A | F | E | H | E | G | I | Q | R | I | T | E | L |
| Query Conservation |   |
  |
|   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |
|   |   |
|
|
|   |
|   |
|   |
|   |   |   |
|   |   |
|
|   |   |   |
|   |   |   |   |
|   |   |   |   |
|   |
|   |   |   |   |   |
|   |
|   |
|   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |
|   |   |   |   |   |
|   |   |   |   |   |   |
|
|
|   |   |
| Template Sequence |   |
Q | L | A | R | I | E | E | A | R | E | Q | R | L | G | S | E | Q | T | K | S | D | Y | L | K | R | A | N | E | L | V | Q | W | I | N | D | K | Q | A | S | L | E | S | R | D | F | G | D | S | I | E | S | V | Q | S | F | M | N | A | H | K | E | Y | K | K | T | E | K | P | P | K | G | Q | E | V | S | E | L | E | A | I |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
|
|
|
|
| S | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | T | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
750 | . | . | . | . | . | . | . | . | . | 760 | . | . | . | . | . | . | . | . | . | 770 | . | . | . | . | . | . | . | . | . | 780 | . | . | . | . | . | . | . | . | . | 790 | . | . | . | . | . | . | . | . | . | 800 | . | . | . | . | . | . | . | . | . | 810 | . | . | . | . | . | . | . | . | . | 820 | . | . | . | . | . | . | . | . | . |
|   |
|   |   |
2005 | . | . | . | . | 2010 | |
|
|
|
|
. | . | . | . | . | . | . | . | . | 2020 | . | . | . | . | . | . | . | . | . | 2030 | . | . | . | . | . | . | . | . | . | 2040 | . | . | . | . | . | . | . | . | . | 2050 | . | . | . | . | . | . | . | . | . | 2060 | . | . | . | . | . | . | . | . | . | 2070 | . | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  | . | . | . | . | . |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
| . |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
K | D | Q | L | V | S | . |
. |
. |
. |
. |
S | E | H | Q | Q | S | P | A | I | E | K | R | H | T | N | V | I | Q | R | W | Q | N | L | L | A | H | S | E | A | R | R | Q | K | L | L | K | M | Q | Q | Q | F | K | Q | I | E | E | L | Y | L | A | F | A | K | K | A | S | T | F | N | S | W | F | E | N | A | E | E | D | L |
| Query Conservation |   |
  |   |   |
|   |   | . | . | . | . | . |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |
|   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|
| Alig confidence |   |
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |
|
|   |   |   |
|   |
|
|   |   |   |   |   |   |
|   |   |   |   |   |   |
|
|
|   |   |   |   |   |
|   |   |   |   |   |
|
|   |
|   |
|   |   |   |   |   |   |   |   |
|
|   |   |
|   |
|   |   |   |   |   |   |
|   |   |
|
|
|   |   |   |
|   |
|
|
|
| Template Sequence |   |
Y | N | S | L | Q | T | K | L | R | L | I | K | R | E | P | F | V | A | P | A | G | L | T | P | N | E | I | D | S | T | W | S | A | L | E | K | A | E | Q | E | H | A | E | A | L | R | I | E | L | K | R | Q | K | K | I | A | V | L | L | Q | K | Y | N | R | I | L | K | K | L | E | N | W | A | T | T | K | S | V | Y | L |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  | T | T | S |
|
|
|
|
|
| T | T |
| S |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | G | G | G | T | G | G |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
830 | . | . | . | . | . | . | . | . | . | 840 | . | . | . | . | . | . | . | . | . | 850 | . | . | . | . | . | . | . | . | . | 860 | . | . | . | . | . | . | . | . | . | 870 | . | . | . | . | . | . | . | . | . | 880 | . | . | . | . | . | . | . | . | . | 890 | . | . | . | . | . | . | . | . | . | 900 | . | . | . | . | . | . | . | . | . |
|   |
|   |   |
2080 | . | . | . | . | . | . | . | . | . | 2090 | . | . | . | . | . | . | . | . | . | 2100 | . | . | . | . | . | . | . | . | . | 2110 | . | . | |
. | . | . | . | . | . | . | 2120 | . | . | . | . | . | . | |
. | . | . | 2130 | . | . | . | . | . | . | . | . | . | 2140 | . | . | . | . | . | . | . | . | . | 2150 | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . |  |  |  |  |  |  |  |  |  |  |  |  |
|
| . |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
T | D | P | V | R | C | N | S | L | E | E | I | R | A | L | R | D | A | H | G | E | F | Q | R | S | L | S | S | A | E | E | D | F | . |
R | Q | L | Q | D | L | D | R | R | I | K | S | F | N | . |
V | G | P | N | P | Y | T | W | F | T | M | D | A | L | E | D | T | W | R | N | L | Q | R | I | I | K | E | R | E | Q | E |
| Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   | . |   |   |
|   |   |   |   |   |   |
|   |   |   |   | . |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|   |   |
|
|
|   |   |
|   |
|
|
|   |
|
|   |
|
|
|   |
|   |   |
|
|
|   |   |   |   |
|   |   |   |
|
|   |   |
|   |
|
|
|   |
|
|
|
|   |   |   |   |   |   |   |
|
|   |   |
|   |
|   |
|   |
|   |   |
|
|   |   |   |
|   |   |   |   |   |
| Template Sequence |   |
G | S | N | E | T | G | D | S | I | T | A | V | Q | A | K | L | K | N | L | E | A | F | D | G | E | C | Q | S | L | E | G | Q | S | N | S | D | L | L | S | I | L | A | Q | L | T | E | L | N | Y | N | G | V | P | E | L | T | E | R | K | D | T | F | F | A | Q | Q | W | T | G | V | K | S | S | A | E | T | Y | K | N | T |
| Template Known Secondary structure |   |
G |
|
| S | S |
|
| S |  |  |  |  |  |  |  | T | T |  |  |  |  |  |  |  |  | T |  |  |  |  | T |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | T | T |
| T | T |  |  |  |  |  |  |  |  |  |  |  | T | T | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
910 | . | . | . | . | . | . | . | . | . | 920 | . | . | . | . | . | . | . | . | . | 930 | . | . | . | . | . | . | . | . | . | 940 | . | . | . | . | . | . | . | . | . | 950 | . | . | . | . | . | . | . | . | . | 960 | . | . | . | . | . | . | . | . | . | 970 | . | . | . | . | . | . | . | . | . | 980 | . | . | . | . | . | . | . | . | . |
|   |
|   |   |
2158 | . | 2160 | . | . | . | . | . | . | . | . | . | 2170 | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
L | A | R | E | H | Q | R | Q | E | E | N | D | K | L |
| Query Conservation |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|   |   |
|   |
|
|
|
|
|
|
|
|
|
| Template Sequence |   |
L | L | A | E | L | E | R | L | Q | K | I | E | D | L |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
990 | . | . | . | . | . | . | . | . | . | 1000 | . | . | . |
|   |