Phyre 2 Results for Q21408

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Email | l.a.kelley@imperial.ac.uk
Description | Q21408
Date | Sat Apr 13 12:50:02 BST 2013
Unique Job ID | 57539a1906360a68

Summary |

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å): | X:220.985 Y:152.859 Z:64.224
| Close Jmol

Model (left) based on template c1sjjB_
Top template information
PDB header:contractile protein Chain: B: PDB Molecule:actinin; PDBTitle: cryo-em structure of chicken gizzard smooth muscle alpha-2 actinin
Confidence and coverage
Confidence: | 100.0% | Coverage: | 24%
582 residues ( 24% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
1113 residues ( 46%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | A | D | S | N | D | T | H | A | P | P | E | P | V | L | E | V | P | P | P | Q | E | I | R | I | L | E | T | A | D | D | I | H | Q | R | R | Q | E | V | L | G | H | Y | S | I | F | K | D | H | S | Q | T | K | R | D | R | L | E | E | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | R | Q | F | Q | Y | F | K | R | D | A | D | E | L | N | V | W | I | L | E | K | L | Q | T | A | Q | E | E | N | F | R | D | P | S | N | L | Q | A | K | I | Q | K | H | E | A | F | E | A | E | V | Q | A | H | A | K | T | I | A | N | L | D
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | K | T | G | N | A | M | I | Q | H | N | H | F | A | S | E | H | I | K | K | R | L | E | E | L | H | A | L | W | D | K | L | F | F | K | L | K | D | K | G | I | K | L | Q | Q | A | L | K | L | L | H | F | I | R | Q | C | D | E | I | L | Y
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | W | I | R | E | K | E | T | Y | V | T | A | E | D | M | G | M | D | L | E | H | V | E | I | L | Q | R | K | F | D | D | F | L | K | E | L | G | N | H | Q | Y | R | I | N | E | I | N | Q | A | A | D | K | L | V | E | E | G | H | S | E | H
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300
Sequence |  | D | Q | I | Y | K | K | R | D | D | V | N | D | A | W | H | R | L | N | T | L | A | A | T | R | K | E | G | L | F | G | A | H | Q | V | Q | R | F | N | R | D | A | D | E | T | L | A | W | I | G | E | K | D | L | A | L | S | S | D | D | Y
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360
Sequence |  | G | R | D | L | N | N | V | Q | A | L | Q | R | K | H | E | G | T | E | R | D | L | A | A | L | E | G | K | M | L | Q | L | E | K | E | A | H | K | L | A | E | T | H | P | D | R | A | E | A | I | H | Q | K | N | D | D | T | K | A | A | W
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420
Sequence |  | N | A | L | K | E | K | A | Q | H | R | K | D | G | L | E | R | S | F | Q | L | H | R | F | L | A | D | Y | R | D | L | I | S | W | I | G | D | M | K | A | V | I | G | A | D | E | L | A | K | D | V | A | G | A | E | A | L | L | E | S | H
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480
Sequence |  | Q | E | H | K | G | E | I | D | A | R | A | D | S | F | N | Q | T | A | S | A | G | Q | K | L | V | E | M | G | I | P | E | S | P | E | V | Q | E | K | L | E | K | L | D | H | E | K | S | S | L | L | G | L | W | E | E | R | R | I | L | Y
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540
Sequence |  | E | Q | C | M | D | L | Q | L | F | Y | R | D | T | E | Q | A | E | T | W | M | N | K | Q | E | A | F | L | A | N | T | D | L | G | D | S | L | D | S | V | E | H | L | I | K | K | H | E | D | F | E | K | S | L | A | A | Q | E | E | K | I
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . | . | . | 600
Sequence |  | N | A | L | D | E | F | A | T | K | L | I | Q | G | Q | H | Y | A | A | D | D | V | A | E | R | R | Q | A | L | L | D | R | R | R | R | L | L | D | R | A | R | Q | R | G | N | A | L | K | E | S | Y | K | R | Q | T | F | D | R | D | C | D
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 610 | . | . | . | . | . | . | . | . | . | 620 | . | . | . | . | . | . | . | . | . | 630 | . | . | . | . | . | . | . | . | . | 640 | . | . | . | . | . | . | . | . | . | 650 | . | . | . | . | . | . | . | . | . | 660
Sequence |  | E | M | V | S | W | I | T | E | K | L | S | T | A | R | D | D | S | Y | L | D | P | T | N | I | R | G | K | L | Q | K | H | I | N | F | E | Q | E | L | K | A | N | E | N | R | L | D | D | I | R | S | T | G | E | Q | I | I | D | S | G | H
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 670 | . | . | . | . | . | . | . | . | . | 680 | . | . | . | . | . | . | . | . | . | 690 | . | . | . | . | . | . | . | . | . | 700 | . | . | . | . | . | . | . | . | . | 710 | . | . | . | . | . | . | . | . | . | 720
Sequence |  | F | A | A | D | H | I | G | D | R | L | R | Q | V | N | N | L | W | N | E | L | V | D | A | T | N | K | K | G | A | K | L | R | E | A | G | N | E | Q | Q | F | N | R | N | I | E | D | V | E | A | W | L | S | E | L | E | G | Q | V | A | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 730 | . | . | . | . | . | . | . | . | . | 740 | . | . | . | . | . | . | . | . | . | 750 | . | . | . | . | . | . | . | . | . | 760 | . | . | . | . | . | . | . | . | . | 770 | . | . | . | . | . | . | . | . | . | 780
Sequence |  | E | D | Y | G | K | D | L | V | S | V | Q | N | L | Q | K | K | I | G | L | I | E | S | D | F | N | A | H | N | D | R | V | D | G | I | K | Q | L | A | Q | Q | F | Q | E | E | E | H | F | N | A | P | V | I | V | R | K | Q | E | N | L | Q
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 790 | . | . | . | . | . | . | . | . | . | 800 | . | . | . | . | . | . | . | . | . | 810 | . | . | . | . | . | . | . | . | . | 820 | . | . | . | . | . | . | . | . | . | 830 | . | . | . | . | . | . | . | . | . | 840
Sequence |  | Q | R | Y | N | A | L | R | D | P | L | E | K | R | K | R | K | L | G | E | S | H | Q | G | N | Q | L | F | R | D | I | E | D | E | L | A | W | I | R | E | K | E | Q | V | A | G | S | T | N | R | G | R | D | L | I | G | V | Q | N | L | I
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 850 | . | . | . | . | . | . | . | . | . | 860 | . | . | . | . | . | . | . | . | . | 870 | . | . | . | . | . | . | . | . | . | 880 | . | . | . | . | . | . | . | . | . | 890 | . | . | . | . | . | . | . | . | . | 900
Sequence |  | K | K | Q | Q | A | L | I | A | E | I | A | N | H | D | S | Q | I | E | S | V | S | S | A | A | N | D | M | I | Q | Q | G | H | F | L | A | P | E | I | R | D | K | L | A | Q | L | R | D | N | W | R | I | L | K | S | K | A | E | K | R | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 910 | . | . | . | . | . | . | . | . | . | 920 | . | . | . | . | . | . | . | . | . | 930 | . | . | . | . | . | . | . | . | . | 940 | . | . | . | . | . | . | . | . | . | 950 | . | . | . | . | . | . | . | . | . | 960
Sequence |  | T | D | L | D | D | S | L | Q | A | H | Q | Y | L | S | D | A | N | E | A | D | A | W | M | S | E | K | E | P | I | V | G | S | T | D | Y | G | K | D | E | D | S | A | E | A | L | L | K | K | H | R | A | L | L | S | D | L | E | A | F | K
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 970 | . | . | . | . | . | . | . | . | . | 980 | . | . | . | . | . | . | . | . | . | 990 | . | . | . | . | . | . | . | . | . | 1000 | . | . | . | . | . | . | . | . | . | 1010 | . | . | . | . | . | . | . | . | . | 1020
Sequence |  | G | T | I | E | D | L | R | K | Q | A | S | Q | C | K | Y | Q | E | Q | P | M | G | Q | L | G | R | D | C | V | L | A | L | Y | D | Y | Q | E | K | S | P | R | E | V | S | M | K | K | G | D | V | L | T | L | L | N | A | S | N | R | D | W
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1030 | . | . | . | . | . | . | . | . | . | 1040 | . | . | . | . | . | . | . | . | . | 1050 | . | . | . | . | . | . | . | . | . | 1060 | . | . | . | . | . | . | . | . | . | 1070 | . | . | . | . | . | . | . | . | . | 1080
Sequence |  | W | K | V | E | V | N | D | R | Q | G | F | V | P | A | A | Y | V | K | R | I | E | P | G | T | A | Q | Q | H | A | Q | Q | Q | V | N | S | I | G | G | K | Q | S | E | I | E | D | K | Y | Q | R | L | M | M | L | G | E | T | R | K | R | K
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1090 | . | . | . | . | . | . | . | . | . | 1100 | . | . | . | . | . | . | . | . | . | 1110 | . | . | . | . | . | . | . | . | . | 1120 | . | . | . | . | . | . | . | . | . | 1130 | . | . | . | . | . | . | . | . | . | 1140
Sequence |  | L | E | E | A | C | K | G | Y | Q | L | L | R | E | A | N | D | L | A | E | W | I | K | S | R | T | N | M | A | E | E | A | V | A | A | Q | Q | E | I | G | T | D | L | E | Q | V | E | V | L | Q | K | K | F | D | D | F | K | G | D | L | K
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1150 | . | . | . | . | . | . | . | . | . | 1160 | . | . | . | . | . | . | . | . | . | 1170 | . | . | . | . | . | . | . | . | . | 1180 | . | . | . | . | . | . | . | . | . | 1190 | . | . | . | . | . | . | . | . | . | 1200
Sequence |  | A | N | E | V | R | L | Q | E | M | N | Q | I | A | T | A | L | T | S | V | G | Q | T | E | T | A | V | R | I | R | Q | Q | I | E | D | L | N | A | R | W | R | A | L | E | E | Q | T | E | Q | R | E | Q | Q | L | G | S | A | H | E | V | Q
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1210 | . | . | . | . | . | . | . | . | . | 1220 | . | . | . | . | . | . | . | . | . | 1230 | . | . | . | . | . | . | . | . | . | 1240 | . | . | . | . | . | . | . | . | . | 1250 | . | . | . | . | . | . | . | . | . | 1260
Sequence |  | R | F | H | R | D | V | D | E | T | R | D | W | I | Q | E | K | D | D | A | L | D | S | E | D | F | G | R | D | L | R | S | V | Q | A | L | Q | R | K | H | E | G | V | E | R | D | L | A | A | L | G | D | K | I | K | S | L | D | E | K | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1270 | . | . | . | . | . | . | . | . | . | 1280 | . | . | . | . | . | . | . | . | . | 1290 | . | . | . | . | . | . | . | . | . | 1300 | . | . | . | . | . | . | . | . | . | 1310 | . | . | . | . | . | . | . | . | . | 1320
Sequence |  | N | R | L | R | Q | S | H | P | E | A | A | E | Q | I | Y | D | L | Q | R | E | L | N | E | Q | W | N | R | L | T | S | K | A | N | N | R | K | E | K | L | L | D | S | Y | D | Y | Q | R | F | L | S | D | Y | R | D | L | M | Q | W | I | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1330 | . | . | . | . | . | . | . | . | . | 1340 | . | . | . | . | . | . | . | . | . | 1350 | . | . | . | . | . | . | . | . | . | 1360 | . | . | . | . | . | . | . | . | . | 1370 | . | . | . | . | . | . | . | . | . | 1380
Sequence |  | S | M | N | Q | L | V | S | S | Q | E | L | A | N | D | V | T | G | A | E | A | L | L | E | R | H | Q | E | Y | R | T | E | I | D | S | R | A | A | T | F | Q | A | F | D | Q | F | G | N | Q | L | L | N | S | H | H | Y | A | A | G | D | I
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1390 | . | . | . | . | . | . | . | . | . | 1400 | . | . | . | . | . | . | . | . | . | 1410 | . | . | . | . | . | . | . | . | . | 1420 | . | . | . | . | . | . | . | . | . | 1430 | . | . | . | . | . | . | . | . | . | 1440
Sequence |  | E | N | R | L | Q | G | V | N | E | A | R | K | G | L | E | D | A | W | V | A | R | R | N | I | L | D | Q | C | L | E | L | Q | L | F | Y | R | D | C | E | Q | A | D | T | W | M | S | A | R | E | A | F | L | A | Q | E | D | P | S | G | D
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1450 | . | . | . | . | . | . | . | . | . | 1460 | . | . | . | . | . | . | . | . | . | 1470 | . | . | . | . | . | . | . | . | . | 1480 | . | . | . | . | . | . | . | . | . | 1490 | . | . | . | . | . | . | . | . | . | 1500
Sequence |  | N | V | E | S | L | I | K | K | H | E | D | F | D | K | A | I | N | T | Q | E | E | K | I | K | G | L | K | L | F | A | E | S | L | I | K | N | N | H | Y | D | S | P | A | V | T | R | K | R | D | Q | I | L | D | R | W | N | G | L | K | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1510 | . | . | . | . | . | . | . | . | . | 1520 | . | . | . | . | . | . | . | . | . | 1530 | . | . | . | . | . | . | . | . | . | 1540 | . | . | . | . | . | . | . | . | . | 1550 | . | . | . | . | . | . | . | . | . | 1560
Sequence |  | A | L | I | Q | K | R | F | K | L | G | E | S | Q | T | L | Q | Q | F | S | R | D | A | D | E | I | E | N | W | M | T | E | K | F | Q | I | A | Q | E | E | N | Y | R | D | P | T | N | I | Q | Q | K | H | Q | K | Q | Q | A | F | E | A | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1570 | . | . | . | . | . | . | . | . | . | 1580 | . | . | . | . | . | . | . | . | . | 1590 | . | . | . | . | . | . | . | . | . | 1600 | . | . | . | . | . | . | . | . | . | 1610 | . | . | . | . | . | . | . | . | . | 1620
Sequence |  | L | H | A | N | S | D | R | I | A | A | I | I | Q | A | G | N | N | L | I | E | N | A | K | C | G | G | G | E | A | A | V | S | A | R | L | K | A | L | N | D | Q | W | D | L | L | V | K | T | T | T | E | K | S | Y | R | L | K | E | A | N
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1630 | . | . | . | . | . | . | . | . | . | 1640 | . | . | . | . | . | . | . | . | . | 1650 | . | . | . | . | . | . | . | . | . | 1660 | . | . | . | . | . | . | . | . | . | 1670 | . | . | . | . | . | . | . | . | . | 1680
Sequence |  | K | Q | K | S | F | M | A | A | V | K | D | L | E | F | W | L | G | E | V | E | I | L | L | Q | S | E | D | Y | G | K | D | L | A | S | V | E | N | L | L | K | K | H | S | L | L | E | A | D | I | V | A | H | Q | D | R | V | G | E | M | N
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1690 | . | . | . | . | . | . | . | . | . | 1700 | . | . | . | . | . | . | . | . | . | 1710 | . | . | . | . | . | . | . | . | . | 1720 | . | . | . | . | . | . | . | . | . | 1730 | . | . | . | . | . | . | . | . | . | 1740
Sequence |  | E | Q | A | D | S | L | L | E | N | D | Q | F | Q | G | Q | Q | I | A | E | R | R | K | L | I | A | D | R | Y | D | G | V | K | K | M | A | T | D | R | R | D | K | L | S | K | A | L | N | V | H | Q | F | F | R | D | I | D | D | E | E | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1750 | . | . | . | . | . | . | . | . | . | 1760 | . | . | . | . | . | . | . | . | . | 1770 | . | . | . | . | . | . | . | . | . | 1780 | . | . | . | . | . | . | . | . | . | 1790 | . | . | . | . | . | . | . | . | . | 1800
Sequence |  | W | I | K | E | K | K | L | L | V | S | S | D | D | Y | G | R | D | L | P | G | V | Q | N | L | R | R | K | H | R | R | I | D | T | E | L | A | S | H | E | P | Q | V | S | L | V | K | L | K | G | E | E | L | L | R | S | A | A | E | A | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1810 | . | . | . | . | . | . | . | . | . | 1820 | . | . | . | . | . | . | . | . | . | 1830 | . | . | . | . | . | . | . | . | . | 1840 | . | . | . | . | . | . | . | . | . | 1850 | . | . | . | . | . | . | . | . | . | 1860
Sequence |  | V | G | E | D | Q | I | K | K | R | M | E | D | L | E | Q | S | W | G | Q | I | R | D | L | T | G | N | R | H | Q | R | L | D | E | S | E | A | F | Q | A | F | L | G | D | V | E | E | E | E | A | W | M | N | E | K | Q | Q | I | L | G | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1870 | . | . | . | . | . | . | . | . | . | 1880 | . | . | . | . | . | . | . | . | . | 1890 | . | . | . | . | . | . | . | . | . | 1900 | . | . | . | . | . | . | . | . | . | 1910 | . | . | . | . | . | . | . | . | . | 1920
Sequence |  | D | N | F | G | E | N | M | A | G | V | Q | G | L | L | K | K | H | D | T | F | Q | V | D | L | E | L | H | K | Q | R | V | A | D | L | I | N | K | G | D | T | L | I | H | N | G | N | H | H | A | P | H | I | K | Q | R | C | D | Q | L | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1930 | . | . | . | . | . | . | . | . | . | 1940 | . | . | . | . | . | . | . | . | . | 1950 | . | . | . | . | . | . | . | . | . | 1960 | . | . | . | . | . | . | . | . | . | 1970 | . | . | . | . | . | . | . | . | . | 1980
Sequence |  | A | R | L | I | E | I | E | S | M | A | E | G | R | L | A | K | L | R | D | N | S | A | Y | L | Q | F | M | W | K | C | D | V | V | E | S | W | I | A | E | K | E | Q | Q | V | R | S | E | D | F | G | R | D | L | S | S | V | Q | I | L | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 1990 | . | . | . | . | . | . | . | . | . | 2000 | . | . | . | . | . | . | . | . | . | 2010 | . | . | . | . | . | . | . | . | . | 2020 | . | . | . | . | . | . | . | . | . | 2030 | . | . | . | . | . | . | . | . | . | 2040
Sequence |  | T | K | Q | E | A | F | D | A | G | L | N | A | F | E | H | E | G | I | Q | R | I | T | E | L | K | D | Q | L | V | S | S | E | H | Q | Q | S | P | A | I | E | K | R | H | T | N | V | I | Q | R | W | Q | N | L | L | A | H | S | E | A | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 2050 | . | . | . | . | . | . | . | . | . | 2060 | . | . | . | . | . | . | . | . | . | 2070 | . | . | . | . | . | . | . | . | . | 2080 | . | . | . | . | . | . | . | . | . | 2090 | . | . | . | . | . | . | . | . | . | 2100
Sequence |  | R | Q | K | L | L | K | M | Q | Q | Q | F | K | Q | I | E | E | L | Y | L | A | F | A | K | K | A | S | T | F | N | S | W | F | E | N | A | E | E | D | L | T | D | P | V | R | C | N | S | L | E | E | I | R | A | L | R | D | A | H | G | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 2110 | . | . | . | . | . | . | . | . | . | 2120 | . | . | . | . | . | . | . | . | . | 2130 | . | . | . | . | . | . | . | . | . | 2140 | . | . | . | . | . | . | . | . | . | 2150 | . | . | . | . | . | . | . | . | . | 2160
Sequence |  | F | Q | R | S | L | S | S | A | E | E | D | F | R | Q | L | Q | D | L | D | R | R | I | K | S | F | N | V | G | P | N | P | Y | T | W | F | T | M | D | A | L | E | D | T | W | R | N | L | Q | R | I | I | K | E | R | E | Q | E | L | A | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 2170 | . | . | . | . | . | . | . | . | . | 2180 | . | . | . | . | . | . | . | . | . | 2190 | . | . | . | . | . | . | . | . | . | 2200 | . | . | . | . | . | . | . | . | . | 2210 | . | . | . | . | . | . | . | . | . | 2220
Sequence |  | E | H | Q | R | Q | E | E | N | D | K | L | R | R | E | F | A | K | L | A | N | A | F | H | A | W | L | T | N | T | R | Q | E | M | M | E | A | G | G | T | L | E | E | Q | L | D | A | V | E | R | K | A | K | E | I | K | A | N | K | G | Q
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 2230 | . | . | . | . | . | . | . | . | . | 2240 | . | . | . | . | . | . | . | . | . | 2250 | . | . | . | . | . | . | . | . | . | 2260 | . | . | . | . | . | . | . | . | . | 2270 | . | . | . | . | . | . | . | . | . | 2280
Sequence |  | L | R | Q | I | E | E | K | G | A | M | L | E | R | N | L | I | L | D | N | R | Y | T | E | H | S | T | V | G | I | A | Q | A | W | D | Q | L | D | Q | L | A | M | R | M | Q | H | N | L | E | Q | Q | I | Q | A | R | N | Q | S | G | V | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 2290 | . | . | . | . | . | . | . | . | . | 2300 | . | . | . | . | . | . | . | . | . | 2310 | . | . | . | . | . | . | . | . | . | 2320 | . | . | . | . | . | . | . | . | . | 2330 | . | . | . | . | . | . | . | . | . | 2340
Sequence |  | E | E | A | L | R | E | F | S | M | M | F | K | H | F | D | K | E | K | T | G | R | L | D | H | Q | Q | F | K | S | C | L | R | A | L | G | Y | D | L | P | M | V | D | E | G | Q | P | E | P | E | F | Q | R | I | L | D | I | V | D | P | N
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  | ? |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 2350 | . | . | . | . | . | . | . | . | . | 2360 | . | . | . | . | . | . | . | . | . | 2370 | . | . | . | . | . | . | . | . | . | 2380 | . | . | . | . | . | . | . | . | . | 2390 | . | . | . | . | . | . | . | . | . | 2400
Sequence |  | R | D | G | Y | V | T | L | Q | E | Y | M | A | F | M | I | S | K | E | T | E | N | I | Q | S | S | E | E | I | E | M | A | F | R | A | L | S | K | E | F | R | P | Y | V | T | A | E | E | L | Y | A | N | L | T | P | E | Q | A | E | F | C
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  | ? |  | ? | ? | ? | ? | ? | ? |  | ? |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 2410 | . | . | . | . | . | . | . | . | . | 2420 | . | . | . | . | . | . | . | . | . | 2430 | . | .
Sequence |  | I | R | R | M | K | P | Y | M | D | A | I | S | G | R | S | I | Q | G | G | L | D | Y | E | Q | F | V | H | A | L | F | Q | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)
? | Disordered ( 12%)
| Alpha helix ( 87%)
| Beta strand ( 0%)

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c1sjjB_ |

### PDB 1sjj chain B

Region: 1837 - 2431
Aligned: 582
Modelled: 582
Confidence: 100.0%
Identity: 30%
PDB header:contractile protein
Chain: B: PDB Molecule:actinin;
PDBTitle: cryo-em structure of chicken gizzard smooth muscle alpha-2 actinin

Phyre2
2 |
| c1hciB_ |

### PDB 1hci chain B

Region: 1832 - 2275
Aligned: 443
Modelled: 443
Confidence: 99.9%
Identity: 25%
PDB header:triple-helix coiled coil
Chain: B: PDB Molecule:alpha-actinin 2;
PDBTitle: crystal structure of the rod domain of alpha-actinin

Phyre2
3 |
| c3edvB_ |

### PDB 3edv chain B

Region: 58 - 375
Aligned: 317
Modelled: 317
Confidence: 99.9%
Identity: 19%
PDB header:structural protein
Chain: B: PDB Molecule:spectrin beta chain, brain 1;
PDBTitle: crystal structure of repeats 14-16 of beta2-spectrin

Phyre2
4 |
| c1u4qB_ |

### PDB 1u4q chain B

Region: 64 - 376
Aligned: 313
Modelled: 313
Confidence: 99.9%
Identity: 26%
PDB header:structural protein
Chain: B: PDB Molecule:spectrin alpha chain, brain;
PDBTitle: crystal structure of repeats 15, 16 and 17 of chicken brain2 alpha spectrin

Phyre2
5 |
| c3kbtA_ |

### PDB 3kbt chain A

Region: 62 - 363
Aligned: 280
Modelled: 280
Confidence: 99.8%
Identity: 29%
PDB header:structural protein
Chain: A: PDB Molecule:spectrin beta chain, erythrocyte;
PDBTitle: crystal structure of the ankyrin binding domain of human erythroid2 beta spectrin (repeats 13-15) in complex with the spectrin binding3 domain of human erythroid ankyrin (zu5-ank)

Phyre2
6 |
| d1h8ba_ |

### PDB 1h8b chain A

Region: 2361 - 2431
Aligned: 67
Modelled: 67
Confidence: 99.7%
Identity: 40%
Fold: EF Hand-like
Superfamily: EF-hand
Family: EF-hand modules in multidomain proteins

Phyre2
7 |
| c1cunC_ |

### PDB 1cun chain C

Region: 63 - 272
Aligned: 210
Modelled: 210
Confidence: 99.6%
Identity: 28%
PDB header:structural protein
Chain: C: PDB Molecule:protein (alpha spectrin);
PDBTitle: crystal structure of repeats 16 and 17 of chicken brain2 alpha spectrin

Phyre2
8 |
| c1u5pA_ |

### PDB 1u5p chain A

Region: 167 - 375
Aligned: 209
Modelled: 209
Confidence: 99.6%
Identity: 33%
PDB header:structural protein
Chain: A: PDB Molecule:spectrin alpha chain, brain;
PDBTitle: crystal structure of repeats 15 and 16 of chicken brain2 alpha spectrin

Phyre2
9 |
| c1s35A_ |

### PDB 1s35 chain A

Region: 170 - 375
Aligned: 206
Modelled: 206
Confidence: 99.6%
Identity: 20%
PDB header:structural protein
Chain: A: PDB Molecule:spectrin beta chain, erythrocyte;
PDBTitle: crystal structure of repeats 8 and 9 of human erythroid2 spectrin

Phyre2
10 |
| c3evrA_ |

### PDB 3evr chain A

Region: 2275 - 2429
Aligned: 139
Modelled: 139
Confidence: 99.5%
Identity: 32%
PDB header:signaling protein
Chain: A: PDB Molecule:myosin light chain kinase, green fluorescent
PDBTitle: crystal structure of calcium bound monomeric gcamp2

Phyre2
11 |
| c3fb2B_ |

### PDB 3fb2 chain B

Region: 163 - 371
Aligned: 200
Modelled: 195
Confidence: 99.5%
Identity: 21%
PDB header:structural protein
Chain: B: PDB Molecule:spectrin alpha chain, brain spectrin;
PDBTitle: crystal structure of the human brain alpha spectrin repeats2 15 and 16. northeast structural genomics consortium target3 hr5563a.

Phyre2
12 |
| c3pe0B_ |

### PDB 3pe0 chain B

Region: 167 - 344
Aligned: 178
Modelled: 178
Confidence: 99.5%
Identity: 19%
PDB header:structural protein
Chain: B: PDB Molecule:plectin;
PDBTitle: structure of the central region of the plakin domain of plectin

Phyre2
13 |
| c1quuA_ |

### PDB 1quu chain A

Region: 1932 - 2168
Aligned: 236
Modelled: 236
Confidence: 99.5%
Identity: 30%
PDB header:contractile protein
Chain: A: PDB Molecule:human skeletal muscle alpha-actinin 2;
PDBTitle: crystal structure of two central spectrin-like repeats from2 alpha-actinin

Phyre2
14 |
| c3ek7A_ |

### PDB 3ek7 chain A

Region: 2278 - 2429
Aligned: 136
Modelled: 136
Confidence: 99.4%
Identity: 32%
PDB header:fluorescent protein
Chain: A: PDB Molecule:myosin light chain kinase, green fluorescent protein,
PDBTitle: calcium-saturated gcamp2 dimer

Phyre2
15 |
| c3u0kA_ |

### PDB 3u0k chain A

Region: 2278 - 2429
Aligned: 130
Modelled: 130
Confidence: 99.4%
Identity: 33%
PDB header:fluorescent protein
Chain: A: PDB Molecule:rcamp;
PDBTitle: crystal structure of the genetically encoded calcium indicator rcamp

Phyre2
16 |
| d1ij5a_ |

### PDB 1ij5 chain A

Region: 2138 - 2429
Aligned: 267
Modelled: 267
Confidence: 99.4%
Identity: 15%
Fold: EF Hand-like
Superfamily: EF-hand
Family: Cbp40 (plasmodial specific CaII-binding protein LAV1-2)

Phyre2
17 |
| c3pdyB_ |

### PDB 3pdy chain B

Region: 66 - 268
Aligned: 197
Modelled: 197
Confidence: 99.4%
Identity: 18%
PDB header:structural protein
Chain: B: PDB Molecule:plectin;
PDBTitle: structure of the third and fourth spectrin repeats of the plakin2 domain of plectin

Phyre2
18 |
| c3sibA_ |

### PDB 3sib chain A

Region: 2276 - 2427
Aligned: 128
Modelled: 128
Confidence: 99.4%
Identity: 16%
PDB header:dna binding protein
Chain: A: PDB Molecule:ure3-bp sequence specific dna binding protein;
PDBTitle: crystal structure of ure3-binding protein, wild-type

Phyre2
19 |
| c3f57B_ |

### PDB 3f57 chain B

Region: 162 - 365
Aligned: 181
Modelled: 181
Confidence: 99.4%
Identity: 33%
PDB header:structural protein
Chain: B: PDB Molecule:spectrin beta chain, erythrocyte;
PDBTitle: crystal structure of human erythroid beta spectrin repeats 14 and 152 (ankyrin binding domain)

Phyre2
20 |
| c3lbxB_ |

### PDB 3lbx chain B

Region: 59 - 226
Aligned: 167
Modelled: 167
Confidence: 99.3%
Identity: 21%
PDB header:structural protein
Chain: B: PDB Molecule:spectrin beta chain, erythrocyte;
PDBTitle: crystal structure of the erythrocyte spectrin tetramerization domain2 complex

Phyre2
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
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42 |
43 |
44 |
45 |
46 |
47 |
48 |
49 |
50 |
51 |
52 |
| c3f31B_ |

### PDB 3f31 chain B

Region: 25 - 164
Aligned: 140
Modelled: 140
Confidence: 99.0%
Identity: 57%
PDB header:actin binding, structural protein
Chain: B: PDB Molecule:spectrin alpha chain, brain;
PDBTitle: crystal structure of the n-terminal region of alphaii-spectrin2 tetramerization domain

Phyre2
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164 |
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166 |
167 |
168 |
169 |
170 |
| c3r6nA_ |

### PDB 3r6n chain A

Region: 171 - 555
Aligned: 370
Modelled: 370
Confidence: 98.5%
Identity: 14%
PDB header:cell adhesion
Chain: A: PDB Molecule:desmoplakin;
PDBTitle: crystal structure of a rigid four spectrin repeat fragment of the2 human desmoplakin plakin domain

Phyre2
171 |
172 |
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c1sjjB_ |
|  | 100.0 | 30 | PDB header:contractile protein Chain: B: PDB Molecule:actinin; PDBTitle: cryo-em structure of chicken gizzard smooth muscle alpha-2 actinin
2 | c1hciB_ |
|  | 99.9 | 25 | PDB header:triple-helix coiled coil Chain: B: PDB Molecule:alpha-actinin 2; PDBTitle: crystal structure of the rod domain of alpha-actinin
3 | c3edvB_ |
|  | 99.9 | 19 | PDB header:structural protein Chain: B: PDB Molecule:spectrin beta chain, brain 1; PDBTitle: crystal structure of repeats 14-16 of beta2-spectrin
4 | c1u4qB_ |
|  | 99.9 | 26 | PDB header:structural protein Chain: B: PDB Molecule:spectrin alpha chain, brain; PDBTitle: crystal structure of repeats 15, 16 and 17 of chicken brain2 alpha spectrin
5 | c3kbtA_ |
|  | 99.8 | 29 | PDB header:structural protein Chain: A: PDB Molecule:spectrin beta chain, erythrocyte; PDBTitle: crystal structure of the ankyrin binding domain of human erythroid2 beta spectrin (repeats 13-15) in complex with the spectrin binding3 domain of human erythroid ankyrin (zu5-ank)
6 | d1h8ba_ |
|  | 99.7 | 40 | Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins
7 | c1cunC_ |
|  | 99.6 | 28 | PDB header:structural protein Chain: C: PDB Molecule:protein (alpha spectrin); PDBTitle: crystal structure of repeats 16 and 17 of chicken brain2 alpha spectrin
8 | c1u5pA_ |
|  | 99.6 | 33 | PDB header:structural protein Chain: A: PDB Molecule:spectrin alpha chain, brain; PDBTitle: crystal structure of repeats 15 and 16 of chicken brain2 alpha spectrin
9 | c1s35A_ |
|  | 99.6 | 20 | PDB header:structural protein Chain: A: PDB Molecule:spectrin beta chain, erythrocyte; PDBTitle: crystal structure of repeats 8 and 9 of human erythroid2 spectrin
10 | c3evrA_ |
|  | 99.5 | 32 | PDB header:signaling protein Chain: A: PDB Molecule:myosin light chain kinase, green fluorescent PDBTitle: crystal structure of calcium bound monomeric gcamp2
11 | c3fb2B_ |
|  | 99.5 | 21 | PDB header:structural protein Chain: B: PDB Molecule:spectrin alpha chain, brain spectrin; PDBTitle: crystal structure of the human brain alpha spectrin repeats2 15 and 16. northeast structural genomics consortium target3 hr5563a.
12 | c3pe0B_ |
|  | 99.5 | 19 | PDB header:structural protein Chain: B: PDB Molecule:plectin; PDBTitle: structure of the central region of the plakin domain of plectin
13 | c1quuA_ |
|  | 99.5 | 30 | PDB header:contractile protein Chain: A: PDB Molecule:human skeletal muscle alpha-actinin 2; PDBTitle: crystal structure of two central spectrin-like repeats from2 alpha-actinin
14 | c3ek7A_ |
|  | 99.4 | 32 | PDB header:fluorescent protein Chain: A: PDB Molecule:myosin light chain kinase, green fluorescent protein, PDBTitle: calcium-saturated gcamp2 dimer
15 | c3u0kA_ |
|  | 99.4 | 33 | PDB header:fluorescent protein Chain: A: PDB Molecule:rcamp; PDBTitle: crystal structure of the genetically encoded calcium indicator rcamp
16 | d1ij5a_ |
|  | 99.4 | 15 | Fold:EF Hand-like Superfamily:EF-hand Family:Cbp40 (plasmodial specific CaII-binding protein LAV1-2)
17 | c3pdyB_ |
|  | 99.4 | 18 | PDB header:structural protein Chain: B: PDB Molecule:plectin; PDBTitle: structure of the third and fourth spectrin repeats of the plakin2 domain of plectin
18 | c3sibA_ |
|  | 99.4 | 16 | PDB header:dna binding protein Chain: A: PDB Molecule:ure3-bp sequence specific dna binding protein; PDBTitle: crystal structure of ure3-binding protein, wild-type
19 | c3f57B_ |
|  | 99.4 | 33 | PDB header:structural protein Chain: B: PDB Molecule:spectrin beta chain, erythrocyte; PDBTitle: crystal structure of human erythroid beta spectrin repeats 14 and 152 (ankyrin binding domain)
20 | c3lbxB_ |
|  | 99.3 | 21 | PDB header:structural protein Chain: B: PDB Molecule:spectrin beta chain, erythrocyte; PDBTitle: crystal structure of the erythrocyte spectrin tetramerization domain2 complex
21 | d2mysb_ |
| not modelled | 99.3 | 18 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
22 | d1wdcc_ |
| not modelled | 99.3 | 19 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
23 | c2odvA_ |
| not modelled | 99.3 | 14 | PDB header:structural protein Chain: A: PDB Molecule:plectin 1; PDBTitle: crystal structure of a fragment of the plakin domain of plectin, cys2 to ala mutant.
24 | d1kfus_ |
| not modelled | 99.2 | 18 | Fold:EF Hand-like Superfamily:EF-hand Family:Penta-EF-hand proteins
25 | d1wdcb_ |
| not modelled | 99.2 | 18 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
26 | c2iakA_ |
| not modelled | 99.2 | 14 | PDB header:cell adhesion Chain: A: PDB Molecule:bullous pemphigoid antigen 1, isoform 5; PDBTitle: crystal structure of a protease resistant fragment of the plakin2 domain of bullous pemphigoid antigen1 (bpag1)
27 | c2ekwC_ |
| not modelled | 99.2 | 18 | PDB header:contractile protein Chain: C: PDB Molecule:myosin catalytic light chain lc-1, mantle muscle; PDBTitle: the crystal structure of squid myosin s1 in the presence of2 so4 2-
28 | d2zfda1 |
| not modelled | 99.1 | 16 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
29 | c2zfdA_ |
| not modelled | 99.1 | 16 | PDB header:signaling protein/transferase Chain: A: PDB Molecule:calcineurin b-like protein 2; PDBTitle: the crystal structure of plant specific calcium binding protein atcbl22 in complex with the regulatory domain of atcipk14
30 | c2becA_ |
| not modelled | 99.1 | 21 | PDB header:metal binding protein/transport protein Chain: A: PDB Molecule:calcineurin b homologous protein 2; PDBTitle: crystal structure of chp2 in complex with its binding2 region in nhe1 and insights into the mechanism of ph3 regulation
31 | c2doqA_ |
| not modelled | 99.1 | 24 | PDB header:cell cycle Chain: A: PDB Molecule:cell division control protein 31; PDBTitle: crystal structure of sfi1p/cdc31p complex
32 | d2opoa1 |
| not modelled | 99.1 | 20 | Fold:EF Hand-like Superfamily:EF-hand Family:Polcalcin
33 | c2g2bA_ |
| not modelled | 99.1 | 15 | PDB header:immune system Chain: A: PDB Molecule:allograft inflammatory factor 1; PDBTitle: nmr structure of the human allograft inflammatory factor 1
34 | d1jbaa_ |
| not modelled | 99.1 | 19 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
35 | d1ap4a_ |
| not modelled | 99.1 | 24 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
36 | d1lkja_ |
| not modelled | 99.1 | 26 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
37 | c2ktgA_ |
| not modelled | 99.1 | 20 | PDB header:ca-binding protein Chain: A: PDB Molecule:calmodulin, putative; PDBTitle: calmodulin like protein from entamoeba histolytica: solution structure2 and calcium binding properties of a partially folded protein
38 | c2k7bA_ |
| not modelled | 99.1 | 26 | PDB header:metal binding protein Chain: A: PDB Molecule:calcium-binding protein 1; PDBTitle: nmr structure of mg2+-bound cabp1 n-domain
39 | c2lv7A_ |
| not modelled | 99.0 | 28 | PDB header:metal binding protein Chain: A: PDB Molecule:calcium-binding protein 7; PDBTitle: solution structure of ca2+-bound cabp7 n-terminal doman
40 | c2aaoA_ |
| not modelled | 99.0 | 23 | PDB header:transferase Chain: A: PDB Molecule:calcium-dependent protein kinase, isoform ak1; PDBTitle: regulatory apparatus of calcium dependent protein kinase from2 arabidopsis thaliana
41 | c3h4sE_ |
| not modelled | 99.0 | 17 | PDB header:motor protein/calcium binding protein Chain: E: PDB Molecule:kcbp interacting ca2+-binding protein; PDBTitle: structure of the complex of a mitotic kinesin with its2 calcium binding regulator
42 | c2vtgA_ |
| not modelled | 99.0 | 19 | PDB header:metal-binding protein Chain: A: PDB Molecule:ionized calcium-binding adapter molecule 2; PDBTitle: crystal structure of human iba2, trigonal crystal form
43 | c2amiA_ |
| not modelled | 99.0 | 27 | PDB header:cell cycle Chain: A: PDB Molecule:caltractin; PDBTitle: solution structure of the calcium-loaded n-terminal sensor2 domain of centrin
44 | d1np8a_ |
| not modelled | 99.0 | 15 | Fold:EF Hand-like Superfamily:EF-hand Family:Penta-EF-hand proteins
45 | d1wrka1 |
| not modelled | 99.0 | 26 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
46 | d2sasa_ |
| not modelled | 99.0 | 17 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
47 | c2aucC_ |
| not modelled | 99.0 | 19 | PDB header:membrane protein Chain: C: PDB Molecule:myosin a tail interacting protein; PDBTitle: structure of the plasmodium mtip-myoa complex, a key component of the2 parasite invasion motor
48 | c3mseB_ |
| not modelled | 99.0 | 20 | PDB header:transferase Chain: B: PDB Molecule:calcium-dependent protein kinase, putative; PDBTitle: crystal structure of c-terminal domain of pf110239.
49 | d1zaca_ |
| not modelled | 99.0 | 28 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
50 | c1npqA_ |
| not modelled | 99.0 | 28 | PDB header:structural protein Chain: A: PDB Molecule:troponin c; PDBTitle: structure of a rhodamine-labeled n-domain troponin c mutant2 (ca2+ saturated) in complex with skeletal troponin i 115-3 131
51 | d1n0ya_ |
| not modelled | 99.0 | 27 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
52 | c3f31B_ |
|  | 99.0 | 57 | PDB header:actin binding, structural protein Chain: B: PDB Molecule:spectrin alpha chain, brain; PDBTitle: crystal structure of the n-terminal region of alphaii-spectrin2 tetramerization domain
53 | d1owaa_ |
| not modelled | 99.0 | 40 | Fold:Spectrin repeat-like Superfamily:Spectrin repeat Family:Spectrin repeat
54 | c1zmzA_ |
| not modelled | 99.0 | 25 | PDB header:structural protein Chain: A: PDB Molecule:centrin-2; PDBTitle: solution structure of the n-terminal domain (m1-s98) of2 human centrin 2
55 | d1sw8a_ |
| not modelled | 99.0 | 30 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
56 | d1dtla_ |
| not modelled | 99.0 | 26 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
57 | d1avsa_ |
| not modelled | 99.0 | 26 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
58 | c2d58A_ |
| not modelled | 99.0 | 19 | PDB header:metal binding protein Chain: A: PDB Molecule:allograft inflammatory factor 1; PDBTitle: human microglia-specific protein iba1
59 | c3cs1A_ |
| not modelled | 99.0 | 20 | PDB header:metal binding protein Chain: A: PDB Molecule:flagellar calcium-binding protein; PDBTitle: flagellar calcium-binding protein (fcabp) from t. cruzi
60 | d1alva_ |
| not modelled | 99.0 | 18 | Fold:EF Hand-like Superfamily:EF-hand Family:Penta-EF-hand proteins
61 | c3j04E_ |
| not modelled | 99.0 | 18 | PDB header:structural protein Chain: E: PDB Molecule:myosin regulatory light chain 2, smooth muscle major PDBTitle: em structure of the heavy meromyosin subfragment of chick smooth2 muscle myosin with regulatory light chain in phosphorylated state
62 | c3e3rB_ |
| not modelled | 99.0 | 20 | PDB header:calcium binding protein Chain: B: PDB Molecule:calcyphosin; PDBTitle: crystal structure and biochemical characterization of recombinant2 human calcyphosine delineates a novel ef-hand-containing protein3 family
63 | d1h4ba_ |
| not modelled | 99.0 | 20 | Fold:EF Hand-like Superfamily:EF-hand Family:Polcalcin
64 | c2bl0C_ |
| not modelled | 99.0 | 22 | PDB header:muscle protein Chain: C: PDB Molecule:myosin regulatory light chain; PDBTitle: physarum polycephalum myosin ii regulatory domain
65 | c2l2eA_ |
| not modelled | 99.0 | 16 | PDB header:metal binding protein Chain: A: PDB Molecule:calcium-binding protein ncs-1; PDBTitle: solution nmr structure of myristoylated ncs1p in apo form
66 | c2oy6B_ |
| not modelled | 98.9 | 17 | PDB header:contractile protein Chain: B: PDB Molecule:myosin regulatory light chain lc-2; PDBTitle: crystal structure of squid mg.adp myosin s1
67 | c3l19B_ |
| not modelled | 98.9 | 24 | PDB header:transferase Chain: B: PDB Molecule:calcium/calmodulin dependent protein kinase with a kinase PDBTitle: crystal structure of calcium binding domain of cpcdpk3, cgd5_820
68 | d1tn4a_ |
| not modelled | 98.9 | 28 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
69 | d1jf0a_ |
| not modelled | 98.9 | 13 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
70 | d1r2ua_ |
| not modelled | 98.9 | 23 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
71 | d1topa_ |
| not modelled | 98.9 | 25 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
72 | d1df0a1 |
| not modelled | 98.9 | 17 | Fold:EF Hand-like Superfamily:EF-hand Family:Penta-EF-hand proteins
73 | c3q5iA_ |
| not modelled | 98.9 | 22 | PDB header:transferase Chain: A: PDB Molecule:protein kinase; PDBTitle: crystal structure of pbanka_031420
74 | c2jnfA_ |
| not modelled | 98.9 | 23 | PDB header:metal binding protein Chain: A: PDB Molecule:troponin c; PDBTitle: solution structure of fly troponin c, isoform f1
75 | c3k21A_ |
| not modelled | 98.9 | 22 | PDB header:transferase Chain: A: PDB Molecule:calcium-dependent protein kinase 3; PDBTitle: crystal structure of carboxy-terminus of pfc0420w.
76 | d1s6ca_ |
| not modelled | 98.9 | 15 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
77 | d2obha1 |
| not modelled | 98.9 | 26 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
78 | d1hcia4 |
| not modelled | 98.9 | 29 | Fold:Spectrin repeat-like Superfamily:Spectrin repeat Family:Spectrin repeat
79 | c3lijA_ |
| not modelled | 98.9 | 23 | PDB header:transferase Chain: A: PDB Molecule:calcium/calmodulin dependent protein kinase with PDBTitle: crystal structure of full length cpcdpk3 (cgd5_820) in2 complex with ca2+ and amppnp
80 | c2ehbA_ |
| not modelled | 98.9 | 17 | PDB header:signalling protein/transferase Chain: A: PDB Molecule:calcineurin b-like protein 4; PDBTitle: the structure of the c-terminal domain of the protein kinase atsos22 bound to the calcium sensor atsos3
81 | c3ox6C_ |
| not modelled | 98.9 | 25 | PDB header:calcium binding protein Chain: C: PDB Molecule:calcium-binding protein 1; PDBTitle: crystal structure of the calcium sensor calcium-binding protein 12 (cabp1)
82 | c2kn2A_ |
| not modelled | 98.9 | 22 | PDB header:metal binding protein Chain: A: PDB Molecule:calmodulin; PDBTitle: solution structure of the c-terminal domain of soybean calmodulin2 isoform 4 fused with the calmodulin-binding domain of ntmkp1
83 | d1ggwa_ |
| not modelled | 98.9 | 19 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
84 | c3a8rB_ |
| not modelled | 98.9 | 19 | PDB header:calcium binding protein Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: the structure of the n-terminal regulatory domain of a plant nadph2 oxidase
85 | d1dvia_ |
| not modelled | 98.9 | 15 | Fold:EF Hand-like Superfamily:EF-hand Family:Penta-EF-hand proteins
86 | c2ggmA_ |
| not modelled | 98.9 | 25 | PDB header:cell cycle Chain: A: PDB Molecule:centrin-2; PDBTitle: human centrin 2 xeroderma pigmentosum group c protein2 complex
87 | c2lhiA_ |
| not modelled | 98.9 | 26 | PDB header:metal binding protein Chain: A: PDB Molecule:calmodulin, serine/threonine-protein phosphatase 2b PDBTitle: solution structure of ca2+/cna1 peptide-bound ycam
88 | d1sl8a_ |
| not modelled | 98.9 | 13 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
89 | d1fpwa_ |
| not modelled | 98.9 | 15 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
90 | d1rfja_ |
| not modelled | 98.8 | 29 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
91 | c3dtpF_ |
| not modelled | 98.8 | 15 | PDB header:contractile protein Chain: F: PDB Molecule:myosin regulatory light chain; PDBTitle: tarantula heavy meromyosin obtained by flexible docking to2 tarantula muscle thick filament cryo-em 3d-map
92 | c2jojA_ |
| not modelled | 98.8 | 32 | PDB header:cell cycle Chain: A: PDB Molecule:centrin protein; PDBTitle: nmr solution structure of n-terminal domain of euplotes2 octocarinatus centrin
93 | c1s1eA_ |
| not modelled | 98.8 | 17 | PDB header:transport protein Chain: A: PDB Molecule:kv channel interacting protein 1; PDBTitle: crystal structure of kv channel-interacting protein 12 (kchip-1)
94 | c3tz1A_ |
| not modelled | 98.8 | 29 | PDB header:contractile protein Chain: A: PDB Molecule:troponin c; PDBTitle: crystal structure of the ca2+-saturated c-terminal domain of akazara2 scallop troponin c in complex with a troponin i fragment
95 | d1f54a_ |
| not modelled | 98.8 | 26 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
96 | c2fcdA_ |
| not modelled | 98.8 | 24 | PDB header:cell cycle Chain: A: PDB Molecule:myosin light chain 1; PDBTitle: solution structure of n-lobe myosin light chain from2 saccharomices cerevisiae
97 | d1qxpa2 |
| not modelled | 98.8 | 20 | Fold:EF Hand-like Superfamily:EF-hand Family:Penta-EF-hand proteins
98 | c2hpkA_ |
| not modelled | 98.8 | 12 | PDB header:luminescent protein Chain: A: PDB Molecule:photoprotein berovin; PDBTitle: crystal structure of photoprotein berovin from beroe2 abyssicola
99 | c2lmtA_ |
| not modelled | 98.8 | 28 | PDB header:metal binding protein Chain: A: PDB Molecule:calmodulin-related protein 97a; PDBTitle: nmr structure of androcam
100 | d1s6ia_ |
| not modelled | 98.8 | 24 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
101 | d1sl7a_ |
| not modelled | 98.8 | 14 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
102 | d1k94a_ |
| not modelled | 98.8 | 14 | Fold:EF Hand-like Superfamily:EF-hand Family:Penta-EF-hand proteins
103 | d1kful1 |
| not modelled | 98.8 | 15 | Fold:EF Hand-like Superfamily:EF-hand Family:Penta-EF-hand proteins
104 | d1qv0a_ |
| not modelled | 98.8 | 15 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
105 | d1gjya_ |
| not modelled | 98.8 | 17 | Fold:EF Hand-like Superfamily:EF-hand Family:Penta-EF-hand proteins
106 | c1kfxL_ |
| not modelled | 98.8 | 14 | PDB header:hydrolase Chain: L: PDB Molecule:m-calpain large subunit; PDBTitle: crystal structure of human m-calpain form i
107 | d2o5ga1 |
| not modelled | 98.8 | 33 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
108 | d1k9ua_ |
| not modelled | 98.8 | 24 | Fold:EF Hand-like Superfamily:EF-hand Family:Polcalcin
109 | d2pq3a1 |
| not modelled | 98.8 | 29 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
110 | c1fi5A_ |
| not modelled | 98.8 | 32 | PDB header:contractile protein Chain: A: PDB Molecule:protein (troponin c); PDBTitle: nmr structure of the c terminal domain of cardiac troponin2 c bound to the n terminal domain of cardiac troponin i.
111 | d1fi5a_ |
| not modelled | 98.8 | 32 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
112 | c2hq8B_ |
| not modelled | 98.8 | 15 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:coelenterazine-binding protein ca-bound apo form; PDBTitle: crystal structure of coelenterazine-binding protein from2 renilla muelleri in the ca loaded apo form
113 | d1cmga_ |
| not modelled | 98.8 | 26 | Fold:EF Hand-like Superfamily:EF-hand Family:Calmodulin-like
114 | c2a4jA_ |
| not modelled | 98.7 | 32 | PDB header:structural protein Chain: A: PDB Molecule:centrin 2; PDBTitle: solution structure of the c-terminal domain (t94-y172) of2 the human centrin 2 in complex with a 17 residues peptide3 (p1-xpc) from xeroderma pigmentosum group c protein
115 | c1sbjA_ |
| not modelled | 98.7 | 32 | PDB header:contractile protein, structural protein Chain: A: PDB Molecule:troponin c, slow skeletal and cardiac muscles; PDBTitle: nmr structure of the mg2+-loaded c terminal domain of2 cardiac troponin c bound to the n terminal domain of3 cardiac troponin i
116 | c2julA_ |
| not modelled | 98.7 | 18 | PDB header:dna binding protein Chain: A: PDB Molecule:calsenilin; PDBTitle: nmr structure of dream
117 | c1scvA_ |
| not modelled | 98.7 | 32 | PDB header:contractile protein, structural protein Chain: A: PDB Molecule:troponin c, slow skeletal and cardiac muscles; PDBTitle: nmr structure of the c terminal domain of cardiac troponin2 c bound to the n terminal domain of cardiac troponin i
118 | c2f33A_ |
| not modelled | 98.7 | 18 | PDB header:metal binding protein Chain: A: PDB Molecule:calbindin; PDBTitle: nmr solution structure of ca2+-loaded calbindin d28k
119 | c2k7cA_ |
| not modelled | 98.7 | 28 | PDB header:metal binding protein Chain: A: PDB Molecule:calcium-binding protein 1; PDBTitle: nmr structure of mg2+-bound cabp1 c-domain
120 | c1juoB_ |
| not modelled | 98.7 | 14 | PDB header:metal transport Chain: B: PDB Molecule:sorcin; PDBTitle: crystal structure of calcium-free human sorcin: a member of2 the penta-ef-hand protein family

Binding site prediction |

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