Email l.a.kelley@imperial.ac.uk Description Q9TYT3 Date Sat Apr 13 13:01:24 BST 2013 Unique Job ID 2b16cb7caa7c6c32

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1oy2a_ 100.0 21 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 2 c3suzA_ 100.0 22 PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family a member PDBTitle: crystal structure of rat mint2 ppc 3 c3sv1C_ 100.0 23 PDB header:protein binding Chain: C: PDB Molecule:amyloid beta a4 precursor protein-binding family a member PDBTitle: crystal structure of app peptide bound rat mint2 parm 4 d1p3ra_ 100.0 17 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 5 c3d8dA_ 100.0 17 PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member PDBTitle: crystal structure of the human fe65-ptb1 domain 6 c2m38A_ 100.0 22 PDB header:peptide binding protein Chain: A: PDB Molecule:ankyrin repeat and sterile alpha motif domain-containing PDBTitle: ptb domain of aida1 7 d1wj1a_ 100.0 22 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 8 d1ntva_ 100.0 16 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 9 d1aqca_ 100.0 25 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 10 c3so6A_ 100.0 20 PDB header:protein binding/protein transport Chain: A: PDB Molecule:ldl receptor adaptor protein; PDBTitle: crystal structure of the ldl receptor tail in complex with autosomal2 recessive hypercholesterolemia ptb domain 11 d2dkqa1 100.0 25 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 12 c2yszA_ 100.0 18 PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family PDBTitle: solution structure of the chimera of the c-terminal pid2 domain of fe65l and the c-terminal tail peptide of app 13 c2elaB_ 99.9 16 PDB header:cell cycle Chain: B: PDB Molecule:adapter protein containing ph domain, ptb domain PDBTitle: crystal structure of the ptb domain of human appl1 14 c2gsbA_ 99.9 34 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 15 c2dcrA_ 99.9 29 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 16 c2hdxB_ 99.9 28 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 17 c3dxeC_ 99.9 19 PDB header:protein binding Chain: C: PDB Molecule:amyloid beta a4 protein-binding family b member PDBTitle: crystal structure of the intracellular domain of human app2 (t668a mutant) in complex with fe65-ptb2 18 c2yt1A_ 99.9 19 PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 protein and amyloid beta a4 PDBTitle: solution structure of the chimera of the c-terminal tail2 peptide of app and the c-terminal pid domain of fe65l 19 c2kk6A_ 99.9 36 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 20 d1ddma_ 99.9 28 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 21 c2eo6A_ not modelled 99.9 22 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 22 d1mila_ 99.9 47 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 23 c2dlzA_ not modelled 99.9 19 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 24 c2eo3A_ not modelled 99.9 28 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 25 c2dyqA_ not modelled 99.9 22 PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member PDBTitle: crystal structure of the c-terminal phophotyrosine interaction domain2 of human apbb3 26 d2cy5a1 not modelled 99.9 11 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 27 c2dlyA_ not modelled 99.9 22 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 28 d3c7ia1 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 29 c2lqnA_ not modelled 99.9 28 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 30 d2oq1a1 not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 31 c2b3oA_ not modelled 99.9 29 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 32 d1wgua_ not modelled 99.9 22 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 33 d2shpa2 not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 34 c2oq1A_ not modelled 99.9 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 35 d1fhsa_ not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 36 d1wvha1 not modelled 99.9 20 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB) 37 c1ka6A_ not modelled 99.9 27 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 38 c3hizB_ not modelled 99.9 28 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 39 c1x6cA_ not modelled 99.9 27 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 40 c2eobA_ not modelled 99.9 26 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 41 c2crhA_ not modelled 99.9 22 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 42 d1rjaa_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 43 d1opka2 not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 44 c2ci8A_ not modelled 99.9 27 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 45 d1blja_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 46 c2shpA_ not modelled 99.9 25 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 47 c2fo0A_ not modelled 99.9 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 48 d1a81e1 not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 49 d1a81e2 not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 50 d1d4ta_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 51 d2izva2 not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 52 d1jwoa_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 53 d1a81a1 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 54 d1pica_ not modelled 99.9 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 55 d1ayaa_ not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 56 c3gqiB_ not modelled 99.9 28 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 57 c2y3aB_ not modelled 99.9 22 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 58 c2ablA_ not modelled 99.9 29 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 59 d2oq1a2 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 60 d1csya_ not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 61 d1nrva_ not modelled 99.9 23 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 62 c2ozoA_ not modelled 99.9 23 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 63 c2lctA_ not modelled 99.9 21 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 64 c2ysxA_ not modelled 99.9 29 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 65 d1a81a2 not modelled 99.9 22 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 66 d1k9aa2 not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 67 c2ge9A_ not modelled 99.9 28 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 68 c2augB_ not modelled 99.9 24 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 69 d1r1qa_ not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 70 c1oplA_ not modelled 99.9 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 71 c2hmhA_ not modelled 99.9 19 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 72 d2cs0a1 not modelled 99.9 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 73 c1k9aB_ not modelled 99.9 28 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 74 c4fl2A_ not modelled 99.9 26 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 75 c3ps5A_ not modelled 99.9 28 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 76 d1bkla_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 77 d2qmsa1 not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 78 d1f2fa_ not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 79 d1jyra_ not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 80 d2eyva1 not modelled 99.9 36 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 81 d1lkka_ not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 82 d2fcia1 not modelled 99.9 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 83 d1i3za_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 c2vifA_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 85 d1fu6a_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 86 c1y57A_ not modelled 99.9 22 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 87 d2shpa3 not modelled 99.9 36 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 88 d1o48a_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 89 c1a81E_ not modelled 99.9 21 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 90 c2c9wA_ not modelled 99.9 27 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 91 d1qcfa2 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 92 d1g83a2 not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 93 c1x27F_ not modelled 99.9 31 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 94 c2dm0A_ not modelled 99.9 30 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk 95 d1xa6a2 not modelled 99.9 25 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 96 c2izvA_ not modelled 99.9 21 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 97 d1qada_ not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 98 c3nhnA_ not modelled 99.9 26 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 99 c2knoA_ not modelled 99.9 31 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 100 d1luia_ not modelled 99.9 35 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 101 c2h8hA_ not modelled 99.9 27 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 102 c2c0iA_ not modelled 99.9 24 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 103 c2ekxA_ not modelled 99.9 30 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain 104 d2c9wa2 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 105 c1rqqC_ not modelled 99.8 26 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 106 d1rpya_ not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 107 c3mazA_ not modelled 99.8 20 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 108 c2el8A_ not modelled 99.8 17 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 109 c3gxxB_ not modelled 99.8 16 PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b 110 c1g83A_ not modelled 99.8 29 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 111 c2eyzA_ not modelled 99.8 32 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 112 c2cr4A_ not modelled 99.8 18 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 113 c2dvjA_ not modelled 99.8 30 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 114 d1cwea_ not modelled 99.8 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 115 c3qwyA_ not modelled 99.8 29 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 116 c3qwxX_ not modelled 99.8 29 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 117 c2eyyA_ not modelled 99.8 26 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 118 c2xp1A_ not modelled 99.8 20 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 119 c2dx0B_ not modelled 99.7 37 PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2 120 c3or8A_ not modelled 99.7 18 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6