BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (316 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q9TYT3 Putative uncharacterized protein n=4 Tax=Caenorh...   654   0.0  
UniRef50_A8WZ72 C. briggsae CBR-SHC-1 protein n=2 Tax=Caenorhabd...   352   1e-95
UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming pr...   123   7e-27
UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=...    98   3e-19
UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi...    95   4e-18
UniRef50_A7RR81 Predicted protein n=1 Tax=Nematostella vectensis...    92   2e-17
UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi...    92   3e-17
UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Ta...    92   3e-17
UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain pr...    91   7e-17
UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi...    90   8e-17
UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=...    89   1e-16
UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda Rep...    89   2e-16
UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2...    88   3e-16
UniRef50_UPI0001A5EB2D PREDICTED: hypothetical protein XP_002347...    88   5e-16
UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein...    87   6e-16
UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=S...    84   7e-15
UniRef50_A8P596 SH2 domain containing protein n=1 Tax=Brugia mal...    82   3e-14
UniRef50_B4IYA5 GH15138 n=5 Tax=Drosophila RepID=B4IYA5_DROGR          80   7e-14
UniRef50_Q6NPB1 RH57813p n=16 Tax=Neoptera RepID=Q6NPB1_DROME          80   7e-14
UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Siluran...    80   9e-14
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...    74   8e-12
UniRef50_Q59HB0 SHC (Src homology 2 domain containing) transform...    72   4e-11
UniRef50_Q5T189 SHC (Src homology 2 domain containing) transform...    71   4e-11
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...    64   9e-09
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...    62   4e-08
UniRef50_UPI00006A1C31 UPI00006A1C31 related cluster n=1 Tax=Xen...    60   9e-08
UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putativ...    59   2e-07
UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein...    59   2e-07
UniRef50_UPI00006A1C30 UPI00006A1C30 related cluster n=1 Tax=Xen...    58   4e-07
UniRef50_Q18684 Protein T13H10.1, confirmed by transcript eviden...    58   4e-07
UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus...    58   4e-07
UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pe...    58   5e-07
UniRef50_A7RZ47 Predicted protein n=1 Tax=Nematostella vectensis...    57   6e-07
UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes relate...    57   8e-07
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...    56   1e-06
UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID...    56   2e-06
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...    56   2e-06
UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorh...    55   3e-06
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...    55   3e-06
UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia mal...    55   3e-06
UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Tak...    55   4e-06
UniRef50_Q9BRG2 SH2 domain-containing protein 3A n=12 Tax=Euther...    55   4e-06
UniRef50_A9V4N6 Predicted protein n=1 Tax=Monosiga brevicollis R...    55   4e-06
UniRef50_Q4S6Q5 Chromosome undetermined SCAF14724, whole genome ...    54   6e-06
UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio Rep...    54   7e-06
UniRef50_Q4SMI9 Chromosome 18 SCAF14547, whole genome shotgun se...    54   7e-06
UniRef50_B0WI58 Putative uncharacterized protein n=2 Tax=Culicin...    54   7e-06
UniRef50_UPI00017B1E0A UPI00017B1E0A related cluster n=1 Tax=Tet...    54   8e-06
UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76...    54   1e-05
UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, part...    54   1e-05
UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein act...    53   1e-05
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...    53   2e-05
UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein ...    53   2e-05
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...    52   2e-05
UniRef50_UPI000186DA97 tyrosine-protein kinase transforming prot...    52   2e-05
UniRef50_Q8AVM4 Sh2d3c-prov protein n=7 Tax=Euteleostomi RepID=Q...    52   2e-05
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...    52   2e-05
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...    52   2e-05
UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun se...    52   3e-05
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...    52   3e-05
UniRef50_UPI000192756A PREDICTED: similar to predicted protein n...    52   3e-05
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...    52   3e-05
UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group Rep...    52   4e-05
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...    51   5e-05
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...    51   6e-05
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...    51   6e-05
UniRef50_A2AK86 SH2 domain containing 3C (Fragment) n=4 Tax=Eute...    51   6e-05
UniRef50_A8WHN9 Novel protein similar to vertebrate breast cance...    51   7e-05
UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activati...    50   8e-05
UniRef50_A2BDR5 SH2 domain containing 3C (Fragment) n=4 Tax=Eute...    50   9e-05
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...    50   9e-05
UniRef50_B7PEL7 Signal transduction protein lnk-realted, putativ...    50   1e-04
UniRef50_UPI00006A5E95 PREDICTED: similar to HrSH2 n=1 Tax=Ciona...    50   1e-04
UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3...    50   1e-04
UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eu...    50   1e-04
UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME        50   1e-04
UniRef50_Q21055 Protein tyrosine phosphatase n=3 Tax=Caenorhabdi...    50   1e-04
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...    50   1e-04
UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE       50   1e-04
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...    50   1e-04
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...    49   2e-04
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...    49   2e-04
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...    49   2e-04
UniRef50_UPI00015B58E2 PREDICTED: similar to signal transduction...    49   2e-04
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...    49   2e-04
UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephyd...    49   2e-04
UniRef50_Q8N5H7 SH2 domain-containing protein 3C n=39 Tax=Amniot...    49   2e-04
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS           49   2e-04
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...    49   2e-04
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...    49   2e-04
UniRef50_C3XYL7 Putative uncharacterized protein n=2 Tax=Branchi...    49   3e-04
UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS          49   3e-04
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...    49   3e-04
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO           49   3e-04
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...    49   3e-04
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...    49   3e-04
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...    49   3e-04
UniRef50_Q9XXE5 Protein Y43C5B.2, partially confirmed by transcr...    49   3e-04
UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=...    49   3e-04
UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax...    48   4e-04
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...    48   4e-04
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...    48   4e-04
UniRef50_A9USG6 Predicted protein n=1 Tax=Monosiga brevicollis R...    48   4e-04
UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=...    48   4e-04
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...    48   4e-04
UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidenc...    48   4e-04
UniRef50_UPI000180B456 PREDICTED: similar to SH2 domain-containi...    48   5e-04
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...    48   5e-04
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...    48   5e-04
UniRef50_UPI0000DB7594 PREDICTED: similar to CG9098-PA, isoform ...    48   5e-04
UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, part...    48   6e-04
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...    47   8e-04
UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4...    47   8e-04
UniRef50_B3RQY3 Putative uncharacterized protein n=1 Tax=Trichop...    47   8e-04
UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n...    47   8e-04
UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=...    47   0.001
UniRef50_UPI00019255F9 PREDICTED: similar to V-crk sarcoma virus...    47   0.001
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...    47   0.001
UniRef50_Q9N4T6 Putative uncharacterized protein n=1 Tax=Caenorh...    47   0.001
UniRef50_A8WMP8 Putative uncharacterized protein n=1 Tax=Caenorh...    47   0.001
UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS          47   0.001
UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9...    47   0.001
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...    47   0.001
UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O...    47   0.001
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...    47   0.001
UniRef50_UPI00019269FE PREDICTED: similar to protein tyrosine ph...    47   0.001
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...    47   0.001
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...    47   0.001
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...    46   0.001
UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus ...    46   0.001
UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogast...    46   0.001
UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 ...    46   0.002
UniRef50_UPI00015B5D64 PREDICTED: similar to LD41184p n=1 Tax=Na...    46   0.002
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...    46   0.002
UniRef50_UPI0000523E1B PREDICTED: similar to Crk-like protein n=...    46   0.002
UniRef50_O44235 HrSH2 protein n=1 Tax=Halocynthia roretzi RepID=...    46   0.002
UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pe...    46   0.002
UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2...    46   0.002
UniRef50_UPI0000612FE6 UPI0000612FE6 related cluster n=1 Tax=Bos...    46   0.002
UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis R...    46   0.002
UniRef50_UPI00017925DF PREDICTED: similar to CG11146 CG11146-PA ...    46   0.002
UniRef50_Q4SW52 Chromosome undetermined SCAF13690, whole genome ...    46   0.002
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...    46   0.002
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...    46   0.002
UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria...    46   0.002
UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=...    46   0.002
UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA     46   0.002
UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_D...    46   0.002
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...    45   0.002
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...    45   0.002
UniRef50_A7SCW1 Predicted protein n=1 Tax=Nematostella vectensis...    45   0.002
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...    45   0.002
UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related ad...    45   0.003
UniRef50_A9USN6 Predicted protein n=1 Tax=Monosiga brevicollis R...    45   0.003
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...    45   0.003
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...    45   0.003
UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 ...    45   0.003
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...    45   0.003
UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clu...    45   0.003
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...    45   0.003
UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...    45   0.003
UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=S...    45   0.004
UniRef50_Q54U31 Dual specificity protein kinase shkD n=1 Tax=Dic...    45   0.004
UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6...    45   0.004
UniRef50_A9V2L8 Predicted protein n=1 Tax=Monosiga brevicollis R...    45   0.004
UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia ...    45   0.004
UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicin...    45   0.004
UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera...    45   0.005
UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosph...    45   0.005
UniRef50_O14492 SH2B adapter protein 2 n=4 Tax=Catarrhini RepID=...    45   0.005
UniRef50_A8PJL3 Protein kinase domain containing protein n=1 Tax...    45   0.005
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...    45   0.005
UniRef50_B1NJG1 Suppressor of cytokine signaling 2 (Fragment) n=...    44   0.005
UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homo...    44   0.005
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...    44   0.005
UniRef50_Q5SQS7 SH2 domain-containing protein 4B n=28 Tax=Eutele...    44   0.005
UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateri...    44   0.005
UniRef50_Q18865 Putative uncharacterized protein n=6 Tax=Caenorh...    44   0.006
UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1...    44   0.006
UniRef50_B7Q2R0 Adaptor protein Crk, putative (Fragment) n=1 Tax...    44   0.006
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...    44   0.006
UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X...    44   0.006
UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN          44   0.006
UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specif...    44   0.006
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...    44   0.006
UniRef50_UPI00005A0859 PREDICTED: similar to SH2 domain containi...    44   0.006
UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein ki...    44   0.007
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...    44   0.007
UniRef50_UPI0000E4816C PREDICTED: similar to phosphoinositide-3-...    44   0.007
UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicu...    44   0.007
UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax...    44   0.007
UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambi...    44   0.007
UniRef50_O01798 Defective spermatogenesis protein 8 n=3 Tax=Caen...    44   0.007
UniRef50_C4QQ21 Expressed protein n=1 Tax=Schistosoma mansoni Re...    44   0.007
UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis...    44   0.007
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...    44   0.008
UniRef50_B5DYC5 GA27425 n=4 Tax=Drosophila RepID=B5DYC5_DROPS          44   0.008
UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=...    44   0.008
UniRef50_UPI0001925DBE PREDICTED: similar to predicted protein n...    44   0.008
UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor recep...    44   0.009
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...    44   0.009
UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax...    44   0.009
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...    44   0.009
UniRef50_UPI0000F2C764 PREDICTED: similar to SH2-containing prot...    44   0.009
UniRef50_A9V6N4 Predicted protein n=1 Tax=Monosiga brevicollis R...    44   0.010
UniRef50_UPI00016E9A01 UPI00016E9A01 related cluster n=3 Tax=Tet...    44   0.010
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...    44   0.010
UniRef50_UPI00006A1A97 SH2B adapter protein 2 (SH2 and PH domain...    44   0.010
UniRef50_Q4TIA8 Chromosome undetermined SCAF2282, whole genome s...    43   0.011
UniRef50_Q4SPM1 Chromosome 16 SCAF14537, whole genome shotgun se...    43   0.012
UniRef50_C4Q974 Growth factor receptor-bound protein, putative n...    43   0.013
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...    43   0.013
UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax...    43   0.013
UniRef50_UPI00017B392D UPI00017B392D related cluster n=2 Tax=Tet...    43   0.013
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...    43   0.013
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...    43   0.014
UniRef50_UPI000179134F PREDICTED: similar to signal transduction...    43   0.014
UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1...    43   0.015
UniRef50_A1L2D2 Src homology 2 domain containing transforming pr...    43   0.015
UniRef50_UPI00015B496D PREDICTED: similar to conserved hypotheti...    43   0.016
UniRef50_Q9XYM0 Adapter molecule Crk n=8 Tax=Endopterygota RepID...    43   0.016
UniRef50_B8JL24 Novel protein similar to human and mouse SH2 dom...    43   0.017
UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeoc...    43   0.017
UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform ...    43   0.018
UniRef50_Q56A36 Hematopoietic SH2 domain-containing protein homo...    43   0.018
UniRef50_Q7K137 Lnk, isoform A n=13 Tax=Drosophila RepID=Q7K137_...    43   0.019
UniRef50_Q29CU6 GA13993 n=10 Tax=Neoptera RepID=Q29CU6_DROPS           43   0.019
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...    42   0.020
UniRef50_UPI000192628F PREDICTED: similar to chimerin (chimaerin...    42   0.020
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...    42   0.020
UniRef50_A8Q767 Protein kinase domain containing protein n=1 Tax...    42   0.021
UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA    42   0.021
UniRef50_A2RUZ0 Zgc:158474 protein n=2 Tax=Euteleostomi RepID=A2...    42   0.022
UniRef50_C3Y4J7 Putative uncharacterized protein n=1 Tax=Branchi...    42   0.023
UniRef50_Q2I6J0 Phosphatidylinositol-3,4,5-trisphosphate 5-phosp...    42   0.023
UniRef50_Q9JID9 SH2B adapter protein 2 n=13 Tax=Euteleostomi Rep...    42   0.024
UniRef50_Q21429 Protein K11E4.2, confirmed by transcript evidenc...    42   0.025
UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax...    42   0.026
UniRef50_Q7YSY1 Fes-like tyrosine kinase protein n=5 Tax=Schisto...    42   0.027
UniRef50_C3YQJ2 Putative uncharacterized protein n=4 Tax=Branchi...    42   0.027
UniRef50_C4Q4A1 Term=tyrosine kinase 5;db_xref=PMID:11289068;wit...    42   0.027
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...    42   0.028
UniRef50_UPI00015B5375 PREDICTED: similar to tensin n=1 Tax=Naso...    42   0.029
UniRef50_Q4RP74 Chromosome 1 SCAF15008, whole genome shotgun seq...    42   0.029
UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistoso...    42   0.030
UniRef50_D2HL11 Putative uncharacterized protein (Fragment) n=4 ...    42   0.031
UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine ki...    42   0.031
UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME         42   0.034
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...    42   0.035
UniRef50_Q08BW5 Cytokine inducible SH2 containing protein n=2 Ta...    42   0.036

>UniRef50_Q9TYT3 Putative uncharacterized protein n=4 Tax=Caenorhabditis elegans
           RepID=Q9TYT3_CAEEL
          Length = 316

 Score =  654 bits (1688), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 316/316 (100%), Positives = 316/316 (100%)

Query: 1   MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA 60
           MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA
Sbjct: 1   MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA 60

Query: 61  AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT 120
           AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT
Sbjct: 61  AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT 120

Query: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP 180
           ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP
Sbjct: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP 180

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP 240
           PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP
Sbjct: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP 240

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
           GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS
Sbjct: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300

Query: 301 LNLIRPVPCPGSDDIE 316
           LNLIRPVPCPGSDDIE
Sbjct: 301 LNLIRPVPCPGSDDIE 316


>UniRef50_A8WZ72 C. briggsae CBR-SHC-1 protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8WZ72_CAEBR
          Length = 317

 Score =  352 bits (903), Expect = 1e-95,   Method: Compositional matrix adjust.
 Identities = 176/319 (55%), Positives = 228/319 (71%), Gaps = 15/319 (4%)

Query: 1   MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA 60
           M+ ++P +A+ELRSSGV+L+A YLGS+PV ES++VMVSEMR QVV ECIQ VAA VG+T 
Sbjct: 1   MVKIDPIYAQELRSSGVTLAAVYLGSIPVQESMSVMVSEMRSQVVGECIQIVAAKVGLTP 60

Query: 61  AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT 120
            R++NP+V+R+IGEVK+ENF VD+NISSKM+K+I+ SRLIQRHP SFFSFG+QGQ+GTDT
Sbjct: 61  ERDVNPIVARIIGEVKQENFNVDLNISSKMVKVIRSSRLIQRHPLSFFSFGSQGQRGTDT 120

Query: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTV--- 177
           E MFGYIAKNK+G DRRCHV+  + V KL+D L  AI VNT DA+A     N        
Sbjct: 121 ENMFGYIAKNKNGEDRRCHVMSSKAVQKLLDTLVAAIQVNTEDAKAKEMAENPQAASTSG 180

Query: 178 --------PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG 229
                   P  P +   +     +V+  R   V E+V  + WYHG++SR+ AQ+L++  G
Sbjct: 181 TSGPSSTDPLRPPKFTCT----EYVALGRITLVYENVKNQPWYHGHISRDIAQSLIRQPG 236

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
           DFLVR SDHT GK+VLSG T   +HKHLILLD  N+VRT ++TF  I+EL+  H+ NG  
Sbjct: 237 DFLVRCSDHTTGKFVLSGMTEHGDHKHLILLDEKNQVRTPEKTFPTITELVRSHMENGQP 296

Query: 290 VRSEGRDRETSLNLIRPVP 308
           VRS+G   +T+L L   +P
Sbjct: 297 VRSDGPQNQTALMLENAIP 315


>UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming protein 1 (SH2 domain
           protein C1) (Src homology 2 domain containing
           transforming protein C1) isoform 4 n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A1414
          Length = 442

 Score =  123 bits (309), Expect = 7e-27,   Method: Compositional matrix adjust.
 Identities = 96/307 (31%), Positives = 149/307 (48%), Gaps = 23/307 (7%)

Query: 10  EELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV--GVTAAREINPV 67
           +++   GVS    Y+G V V++S+  +    R QV  E I  V   V     A R   P 
Sbjct: 146 DKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPC 205

Query: 68  ---VSRVIGE--VKKENFPVDINISSKMIKIIKQ--SRLIQRHPFSFFSFGAQGQKGTDT 120
              +S ++G   +K    P+ + +S+  + ++     ++I  H     SF + G    DT
Sbjct: 206 SRPLSAILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDP--DT 263

Query: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP 180
                Y+AK+     R CH+  +E    L   + + I    F+ +      N    V   
Sbjct: 264 AEYVAYVAKDPV-NQRACHI--LECPEGLAQDVISTIG-QAFELRFKQYLRNPPKLVTPH 319

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP 240
               RS L  Q+  S+C        + G+ W+HG LSR +A+ALL+  GDFLVR+S  TP
Sbjct: 320 DSLARSCLLLQARSSSCMP---GHRLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTP 376

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
           G+YVL+G  +  + KHL+L+D    VRT+D  F ++S LI YHV+N + + S G    + 
Sbjct: 377 GQYVLTGLQS-GQPKHLLLVDPEGVVRTKDHRFESVSHLISYHVDNHLPIISAG----SE 431

Query: 301 LNLIRPV 307
           L L +PV
Sbjct: 432 LCLQQPV 438


>UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=1 Tax=Schistosoma
           mansoni RepID=C4QLR4_SCHMA
          Length = 409

 Score = 98.2 bits (243), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 51/119 (42%), Positives = 75/119 (63%), Gaps = 10/119 (8%)

Query: 194 VSNCRAPTVTEDV-----VGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGR 248
           +SN +AP    +      VG+ WY G +SR  A+ LL+ +GDFLVR S   PG++VLSG 
Sbjct: 288 ISNIKAPVGLPNFEHLEPVGEPWYVGKMSRSQAENLLRYDGDFLVRASIQQPGQFVLSG- 346

Query: 249 TAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             + +++HL+L D + +VRT++R F +I  LIDYHV NG  +RS     ++ + LI PV
Sbjct: 347 LQDGKYRHLLLADPNGKVRTKERVFDSIQHLIDYHVQNGAPIRS----LDSEIRLIFPV 401


>UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi RepID=SHC2_MOUSE
          Length = 573

 Score = 94.7 bits (234), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 53/126 (42%), Positives = 77/126 (61%), Gaps = 8/126 (6%)

Query: 167 NASTSNDGFTVPAPPMRHR--SSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQAL 224
           +A +   G T  +PP+  +  S   R++ +    APT  E +  + WYHG +SR  A+ L
Sbjct: 437 HACSVAAGITAASPPLEDQWPSPPTRRAPI----APT-EEQLRQEPWYHGRMSRRAAEKL 491

Query: 225 LKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHV 284
           L+ +GDFLVR S   PG+YVL+G  A  + KHL+L+D    VRT+D  F +IS LIDYH+
Sbjct: 492 LRADGDFLVRDSVTNPGQYVLTGMHA-GQPKHLLLVDPEGVVRTKDVLFESISHLIDYHL 550

Query: 285 NNGMAV 290
            NG+ +
Sbjct: 551 KNGLPI 556


>UniRef50_A7RR81 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7RR81_NEMVE
          Length = 473

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 42/86 (48%), Positives = 61/86 (70%), Gaps = 1/86 (1%)

Query: 209 KVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           K WYHG +SR +A+ LL+ EGDFLVR+S   PG+YVLSG   + + +HL+L+D   +VRT
Sbjct: 377 KDWYHGPISRGEAELLLEDEGDFLVRESKSQPGQYVLSG-IKDKQARHLLLVDPQGQVRT 435

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEG 294
           RD+ F N+ +LI +H+ N + + S G
Sbjct: 436 RDKVFENVDQLISFHLVNQVPIISAG 461



 Score = 58.5 bits (140), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 43/137 (31%), Positives = 64/137 (46%), Gaps = 10/137 (7%)

Query: 12  LRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINP--VVS 69
           LR  GV  +  Y+G + V +S+  +  E+R QV  E I       G    +   P   VS
Sbjct: 35  LREGGVCYAVKYVGCLSVEKSMRTLPYEVRQQVTREAILRCCEAAGYPLPKRKKPHKNVS 94

Query: 70  RVIGEVKKENFP---VDINISSKMIKII--KQSRLIQRHPFSFFSFGAQGQKGTDTELMF 124
           R++GE    N     V++ IS+  +K++     R I  H     SF + G+K  D   M 
Sbjct: 95  RILGETPNMNHSGTNVNLTISATGMKMVDMNNGRRIANHDMQGISFASGGEK--DCVNMV 152

Query: 125 GYIAKNKDGTDRRCHVV 141
           GY+AK+ +   R CHV 
Sbjct: 153 GYVAKD-EVNGRACHVC 168


>UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi RepID=SHC4_HUMAN
          Length = 630

 Score = 91.7 bits (226), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 45/108 (41%), Positives = 70/108 (64%), Gaps = 5/108 (4%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
           P + + +  +  YHG LSR+ A++LL  +GDFLVR+S  +PG+YVLSG     + KHL+L
Sbjct: 515 PHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQG-GQAKHLLL 573

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           +D   +VRT+D  F N+  LI YH++N + + S G +    ++L +PV
Sbjct: 574 VDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSE----VSLKQPV 617


>UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Tax=Eutheria
           RepID=Q6S5L8-2
          Length = 387

 Score = 91.7 bits (226), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 45/108 (41%), Positives = 70/108 (64%), Gaps = 5/108 (4%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
           P + + +  +  YHG LSR+ A++LL  +GDFLVR+S  +PG+YVLSG     + KHL+L
Sbjct: 272 PHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQG-GQAKHLLL 330

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           +D   +VRT+D  F N+  LI YH++N + + S G    + ++L +PV
Sbjct: 331 VDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSG----SEVSLKQPV 374


>UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2
           domain-containing-transforming protein C3) (Neuronal
           Shc) (N-Shc) (Protein Rai). n=15 Tax=Euteleostomi
           RepID=UPI0000ECC29C
          Length = 582

 Score = 90.5 bits (223), Expect = 7e-17,   Method: Compositional matrix adjust.
 Identities = 42/86 (48%), Positives = 58/86 (67%), Gaps = 1/86 (1%)

Query: 209 KVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           K WY G +SR++A+ LLK  GDFLVR+S   PG YVL+G     + KHL+L+D    VRT
Sbjct: 485 KPWYQGEMSRKEAEQLLKKCGDFLVRKSTTNPGSYVLTG-MQNGQAKHLLLVDPEGTVRT 543

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEG 294
           +DR F +IS LI++H+ N + + S G
Sbjct: 544 KDRVFDSISHLINHHLENNLPIVSSG 569



 Score = 42.7 bits (99), Expect = 0.019,   Method: Compositional matrix adjust.
 Identities = 37/144 (25%), Positives = 67/144 (46%), Gaps = 14/144 (9%)

Query: 8   FAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV-GVTAA----R 62
            +E++   GV+    YLG + V+ S+  +    R Q+  E I  V   V G   A    +
Sbjct: 145 LSEKILGPGVTYIVKYLGCIEVLRSMRSLDFNTRTQITREAISRVCEAVPGAKGAFKKRK 204

Query: 63  EINPVVSRVIGE--VKKENFPVDINISSKMIKIIK--QSRLIQRHPFSFFSFGAQGQKGT 118
             + V+S ++G+  ++     + +NIS+  + ++     ++I  H     SF + G    
Sbjct: 205 PPSKVLSSILGKSNLQFAGISIMLNISTTSLNLMTPDMKQIIANHHMQSISFASGGD--P 262

Query: 119 DTELMFGYIAKNKDGTDRR-CHVV 141
           DT     Y+A  KD  +RR CH++
Sbjct: 263 DTTDYVAYVA--KDPVNRRACHIL 284


>UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi RepID=SHC3_HUMAN
          Length = 594

 Score = 90.1 bits (222), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 45/112 (40%), Positives = 72/112 (64%), Gaps = 7/112 (6%)

Query: 198 RAP--TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHK 255
           RAP   + E++  + WY G +SR++A+ LL+ +GDFLVR+S   PG +VL+G     + K
Sbjct: 484 RAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTG-MHNGQAK 542

Query: 256 HLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           HL+L+D    +RT+DR F +IS LI++H+ + + + S G    + L L +PV
Sbjct: 543 HLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAG----SELCLQQPV 590


>UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7Q1P4_IXOSC
          Length = 461

 Score = 89.4 bits (220), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 46/128 (35%), Positives = 76/128 (59%), Gaps = 23/128 (17%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGK 242
           RHR++L +++                  W+HG +SR++++  L  +GDFLVR+S   PG+
Sbjct: 356 RHRATLEKEA------------------WFHGAISRKESEGRLAEDGDFLVRESQGNPGQ 397

Query: 243 YVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLN 302
           +VL+G    +  +HL+L+D    VRT+DRTF ++S L++YH +N + + S     E++L 
Sbjct: 398 FVLTGMQG-SARRHLLLVDPAGVVRTKDRTFDSVSHLVNYHRDNALPIISA----ESALV 452

Query: 303 LIRPVPCP 310
           L  PVP P
Sbjct: 453 LKNPVPRP 460



 Score = 42.0 bits (97), Expect = 0.030,   Method: Compositional matrix adjust.
 Identities = 34/140 (24%), Positives = 65/140 (46%), Gaps = 11/140 (7%)

Query: 10  EELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAA---REINP 66
           +E+   GV+    Y+G + V  S+  +  + R  +  ECI  V    G+ A    R+++ 
Sbjct: 13  QEVLGLGVTYRVRYIGCLDVKMSMKCLDFDTRSLIAKECITRVCEAAGLKAVDKKRKVDR 72

Query: 67  VVSRVIGEVKKENFP---VDINISSKMIK--IIKQSRLIQRHPFSFFSFGAQGQKGTDTE 121
            + R++ E    ++    V++ ++S  +K  I++  + I  H     SF + G    +T 
Sbjct: 73  RLQRMLAERPNMDYAGSNVNLCVTSSSLKLSILETGQAIADHNMPNISFASGGD--AETL 130

Query: 122 LMFGYIAKNKDGTDRRCHVV 141
               Y+AK+  G  R C V+
Sbjct: 131 DFVAYVAKDGQGA-RACLVL 149


>UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda RepID=SHC2_HUMAN
          Length = 582

 Score = 89.0 bits (219), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 44/95 (46%), Positives = 61/95 (64%), Gaps = 3/95 (3%)

Query: 198 RAPTVT--EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHK 255
           RAP     E +  + WYHG +SR  A+ +L+ +GDFLVR S   PG+YVL+G  A  + K
Sbjct: 472 RAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHA-GQPK 530

Query: 256 HLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           HL+L+D    VRT+D  F +IS LID+H+ NG  +
Sbjct: 531 HLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPI 565


>UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2 domain containing)
           transforming protein 1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180D2C5
          Length = 497

 Score = 88.2 bits (217), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 40/94 (42%), Positives = 66/94 (70%), Gaps = 1/94 (1%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
           + T  +  K W+HG+++R++A+ LL  +GDFLVR+S  T G++VLSG   + ++KHL+L+
Sbjct: 390 SATNALQSKPWFHGHVTRKEAEQLLSHDGDFLVRESTTTKGQFVLSG-VQDGQYKHLLLV 448

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
           D +  VRT+DR F ++S LI +H +N + + S G
Sbjct: 449 DPNGVVRTKDRQFDSVSHLISFHRDNTLPIVSSG 482



 Score = 48.5 bits (114), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 61/252 (24%), Positives = 102/252 (40%), Gaps = 27/252 (10%)

Query: 16  GVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVT--------AAREINPV 67
           GV  S  YLG V V +S+  +  +MR     E I  V A+ G++        + R+  P 
Sbjct: 42  GVVYSVQYLGCVEVRQSMRTLDFDMRTLATKEAIWRVLASTGMSPLPPAANRSGRKKPPK 101

Query: 68  -VSRVIGEVKKENFP---VDINISSKMIKII--KQSRLIQRHPFSFFSFGAQGQKGTDTE 121
            V+R++GE     F    +++ IS+  + ++     + I  H     SF + G    DT 
Sbjct: 102 DVTRILGERPNLKFSQSFINLTISTASLTLVVSNTGQFIANHQMQSISFASGGDP--DTI 159

Query: 122 LMFGYIAKNKDGTDRRCHVVFIED--VHKLIDVLTTAINVNTFDAQANASTSNDGFTVPA 179
               Y+AK+   + R CHV+   D     +I+ +  A     F+ +      N    V  
Sbjct: 160 DYVAYVAKDPINS-RACHVLKCTDGLAQDVINTIGQA-----FELRFKEYLKNPPKAV-T 212

Query: 180 PPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHT 239
           PP R     H          P    ++ GK+     L R D  +  K +   +V  + H 
Sbjct: 213 PPDRTEPLFHDGKSRWGDDEPEYYNEIPGKLAPESGLKRLDDGS--KIDEGAVVYPNHHN 270

Query: 240 PGKYVLSGRTAE 251
             +Y+ +G  +E
Sbjct: 271 SQEYINNGMQSE 282


>UniRef50_UPI0001A5EB2D PREDICTED: hypothetical protein XP_002347924 n=1 Tax=Homo sapiens
           RepID=UPI0001A5EB2D
          Length = 475

 Score = 87.8 bits (216), Expect = 5e-16,   Method: Compositional matrix adjust.
 Identities = 44/95 (46%), Positives = 61/95 (64%), Gaps = 3/95 (3%)

Query: 198 RAPTVT--EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHK 255
           RAP     E +  + WYHG +SR  A+ +L+ +GDFLVR S   PG+YVL+G  A  + K
Sbjct: 365 RAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHA-GQPK 423

Query: 256 HLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           HL+L+D    VRT+D  F +IS LID+H+ NG  +
Sbjct: 424 HLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPI 458


>UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein CG3715-PA n=2
           Tax=Apocrita RepID=UPI000051A29D
          Length = 443

 Score = 87.4 bits (215), Expect = 6e-16,   Method: Compositional matrix adjust.
 Identities = 41/100 (41%), Positives = 69/100 (69%), Gaps = 5/100 (5%)

Query: 209 KVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           ++W+HG++SR +A+++L  +GDFLVR+S  +PG+YVL+G    N  KHL+L+D    VRT
Sbjct: 344 EIWFHGSVSRAEAESMLTRDGDFLVRESQGSPGQYVLTGMN-NNTPKHLLLIDPEGVVRT 402

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
           +DR F ++S L+++H +N + + S     ++ L L  P+P
Sbjct: 403 KDRVFDSVSHLVNHHCDNVLPIISA----DSVLVLRYPIP 438



 Score = 47.4 bits (111), Expect = 7e-04,   Method: Compositional matrix adjust.
 Identities = 37/136 (27%), Positives = 65/136 (47%), Gaps = 15/136 (11%)

Query: 16  GVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAA---REINPVVSRVI 72
           G++ +  Y+G + V  S+  +  E R  V  ECI  V    G+ +A   R ++  V R I
Sbjct: 27  GITYTVKYIGCLEVYTSMKSLDFETRSCVAKECINRVCEAAGLKSADKKRRVDRKVLRAI 86

Query: 73  GE---VKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTELM--FG 125
            +   ++     +++ ISS  + +  I+   +I +H     SF +    G DTE++    
Sbjct: 87  ADKPRMEHTGATINLTISSCSLALTNIENGHIIAKHEMPRISFAS----GGDTEILDFVA 142

Query: 126 YIAKNKDGTDRRCHVV 141
           Y+AKN     R C+V+
Sbjct: 143 YVAKNMQEW-RACYVL 157


>UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E4625F
          Length = 520

 Score = 84.0 bits (206), Expect = 7e-15,   Method: Compositional matrix adjust.
 Identities = 42/105 (40%), Positives = 66/105 (62%), Gaps = 5/105 (4%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           T  +  + W+HG +SR++ + LL  +GDFLVR+S     +YVLSG       KHL+L+D 
Sbjct: 415 TNPLYNEEWFHGPMSRKEGEPLLSNDGDFLVRESTTAKDQYVLSG-MQNGTPKHLLLVDP 473

Query: 263 HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             +VRT+D+ F ++S LI+YH NN + + S G    ++++L  PV
Sbjct: 474 QGKVRTKDKEFDSVSHLINYHRNNRLPIISAG----SAVHLKTPV 514


>UniRef50_A8P596 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P596_BRUMA
          Length = 119

 Score = 81.6 bits (200), Expect = 3e-14,   Method: Compositional matrix adjust.
 Identities = 43/98 (43%), Positives = 62/98 (63%), Gaps = 6/98 (6%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD-NHNRVRTR 269
           WYHG + R  A+++L+ EGDFLVR S +T   +VLSG  A +  +H +LLD N  +VR +
Sbjct: 17  WYHGEMERATAESMLRNEGDFLVRISPNTANNFVLSG-IANSVARHFLLLDENDQKVRKQ 75

Query: 270 DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
            + F  I ELI+YH    + + SEG    + L+LIRP+
Sbjct: 76  QQVFETIVELIEYHRGENVPIISEG----SELHLIRPI 109


>UniRef50_B4IYA5 GH15138 n=5 Tax=Drosophila RepID=B4IYA5_DROGR
          Length = 442

 Score = 80.5 bits (197), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 43/111 (38%), Positives = 70/111 (63%), Gaps = 5/111 (4%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
           +  +VW+H  +SR  ++ LL+ +GDFLVR+S    G+YVL+G   +   KHL+L+D    
Sbjct: 328 LTAEVWFHAAISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGK-APKHLLLIDPEGV 386

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDDIE 316
           VRT+DR F +IS LI+YH  + + + SE    ++ L L  PV  P +++++
Sbjct: 387 VRTKDRIFDSISHLINYHWVHALPIISE----DSELVLRNPVRRPANNNLD 433



 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 35/133 (26%), Positives = 60/133 (45%), Gaps = 9/133 (6%)

Query: 16  GVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAA--REINPVVSRVIG 73
           GV+ +  Y G V V  S+  +  E R  +  ECI  V    G+ +A  R ++  +   I 
Sbjct: 33  GVTFNVRYTGCVEVKTSMKSLDFETRTLLARECINRVCEAAGLKSASKRRLDKKLHNFIS 92

Query: 74  E---VKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIA 128
           +   ++     + IN+SS+ + +  ++   +I  H     SF + G    DT     YIA
Sbjct: 93  DRPSMQHAGTNIIINVSSRALTLSNVETGEVIASHNMPRISFASGGD--NDTLDFLAYIA 150

Query: 129 KNKDGTDRRCHVV 141
           K +    R C+V+
Sbjct: 151 KREGDEWRACYVL 163


>UniRef50_Q6NPB1 RH57813p n=16 Tax=Neoptera RepID=Q6NPB1_DROME
          Length = 409

 Score = 80.5 bits (197), Expect = 7e-14,   Method: Compositional matrix adjust.
 Identities = 38/88 (43%), Positives = 58/88 (65%), Gaps = 1/88 (1%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
           +  +VW+H  +SR  ++ LL+ +GDFLVR+S    G+YVL+G   +   KHL+L+D    
Sbjct: 296 LTAEVWFHAGISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGKTP-KHLLLIDPEGV 354

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSE 293
           VRT+DR F +IS LI+YH  + + + SE
Sbjct: 355 VRTKDRIFDSISHLINYHWAHALPIISE 382



 Score = 50.4 bits (119), Expect = 8e-05,   Method: Compositional matrix adjust.
 Identities = 40/131 (30%), Positives = 61/131 (46%), Gaps = 10/131 (7%)

Query: 16  GVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAA---REINPVVSRVI 72
           GV+ +  Y G V V  S+  +  E R Q+  ECI  V    G+ +A   R  N +  R  
Sbjct: 31  GVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRVCEAAGLKSAGKRRLTNFISDRPS 90

Query: 73  GEVKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKN 130
            +    N  + IN+SS+ + +  ++   +I  H     SF + G    DT     YIAKN
Sbjct: 91  MQHAGTN--IIINVSSRALSLSNVETGEVIANHNMPRISFASGGD--NDTLDFLAYIAKN 146

Query: 131 KDGTDRRCHVV 141
           +D   R C+V+
Sbjct: 147 EDEW-RACYVL 156


>UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069FB4F
          Length = 393

 Score = 80.1 bits (196), Expect = 9e-14,   Method: Compositional matrix adjust.
 Identities = 40/97 (41%), Positives = 62/97 (63%), Gaps = 5/97 (5%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD 270
           WYHG ++R+ A++LL  +GDFL+R+S  +  +YVLSG    +  KHL+L+D   +VRT+D
Sbjct: 298 WYHGKMNRKVAESLLVNDGDFLIRESTTSACQYVLSGLQGGHP-KHLLLVDPDGKVRTKD 356

Query: 271 RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             F ++  LI YH+ N + + S G    + L L +PV
Sbjct: 357 HVFESVIHLISYHMENELPIISSG----SELYLRKPV 389


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score = 73.6 bits (179), Expect = 8e-12,   Method: Compositional matrix adjust.
 Identities = 41/116 (35%), Positives = 62/116 (53%), Gaps = 11/116 (9%)

Query: 193 FVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAEN 252
            +S    P   +D     WYHG + R +AQ LLK +GDFLVR+S   PG+YVLS   ++ 
Sbjct: 447 MISISEKPLAEQD-----WYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSV-YSDG 500

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
           + +H I+    N  R     FSNI +LID+H      +      +++ + L+ P+P
Sbjct: 501 QRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVI-----TKKSGVVLLNPIP 551


>UniRef50_Q59HB0 SHC (Src homology 2 domain containing) transforming protein 1
           isoform p66Shc variant (Fragment) n=7 Tax=Euteleostomi
           RepID=Q59HB0_HUMAN
          Length = 377

 Score = 71.6 bits (174), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 44/120 (36%), Positives = 61/120 (50%), Gaps = 15/120 (12%)

Query: 157 INVNTFD----AQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP------TVTEDV 206
           +NV   D    A   A   N      AP    R     + F    R P      ++ E +
Sbjct: 207 VNVQNLDKARQAVGGAGPPNPAINGSAP----RDLFDMKPFEDALRVPPPPQSVSMAEQL 262

Query: 207 VGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
            G+ W+HG LSR +A+ALL+  GDFLVR+S  TPG+YVL+G  +  + KHL+L+D    V
Sbjct: 263 RGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQS-GQPKHLLLVDPEGVV 321


>UniRef50_Q5T189 SHC (Src homology 2 domain containing) transforming protein 1
           (Fragment) n=3 Tax=Homo sapiens RepID=Q5T189_HUMAN
          Length = 296

 Score = 71.2 bits (173), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 43/115 (37%), Positives = 60/115 (52%), Gaps = 15/115 (13%)

Query: 157 INVNTFD----AQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP------TVTEDV 206
           +NV   D    A   A   N      AP    R     + F    R P      ++ E +
Sbjct: 91  VNVQNLDKARQAVGGAGPPNPAINGSAP----RDLFDMKPFEDALRVPPPPQSVSMAEQL 146

Query: 207 VGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
            G+ W+HG LSR +A+ALL+  GDFLVR+S  TPG+YVL+G  +  + KHL+L+D
Sbjct: 147 RGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQS-GQPKHLLLVD 200


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score = 63.5 bits (153), Expect = 9e-09,   Method: Compositional matrix adjust.
 Identities = 32/79 (40%), Positives = 49/79 (62%), Gaps = 3/79 (3%)

Query: 208 GKVWYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
           GK+W+HG +S+++A  LL T G    FLVR SD+TPG Y L  RT EN  +  I    +N
Sbjct: 348 GKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNN 407

Query: 265 RVRTRDRTFSNISELIDYH 283
           +     R +++I ++ID++
Sbjct: 408 QFMMGGRYYNSIGDIIDHY 426



 Score = 51.2 bits (121), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 11/103 (10%)

Query: 211 WYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           WYHG L R  A+  L+     G +L+R+SD  PG +VLS  +  N   H  ++       
Sbjct: 181 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 240

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
              R FS++S+LI Y+ +    ++ E         L+ PV  P
Sbjct: 241 IGGRRFSSLSDLIGYYSHVSCLLKGE--------KLLYPVAPP 275


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score = 61.6 bits (148), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 45/138 (32%), Positives = 68/138 (49%), Gaps = 20/138 (14%)

Query: 178 PAPPMRHRSSLHRQSFVSNCRAPTV---TEDVV--GKVWYHGNLSREDAQALLK---TEG 229
           P  P    SSL       N   P V   T D +   K WYHG LSR + + LL     +G
Sbjct: 249 PTKPKHSISSL-------NTNPPIVKDETPDCIFRDKDWYHGTLSRSECEFLLNEHAKDG 301

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
           ++L+R S+  PG + LS + A N  KH  +L  +N+     R+FSNI EL+ ++ N  + 
Sbjct: 302 EYLIRNSESKPGDFSLSMK-APNRIKHFKILYGNNQYVIGQRSFSNIDELLSHYKNYPIY 360

Query: 290 VRSEGRDRETSLNLIRPV 307
               G+     ++L+ P+
Sbjct: 361 TTENGQ----KMHLLYPL 374


>UniRef50_UPI00006A1C31 UPI00006A1C31 related cluster n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI00006A1C31
          Length = 419

 Score = 60.5 bits (145), Expect = 9e-08,   Method: Compositional matrix adjust.
 Identities = 39/114 (34%), Positives = 53/114 (46%), Gaps = 14/114 (12%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +ED+    WYHG L R+DA+ LL + GDFL+R S  +PG YVLS   A  +  H  ++  
Sbjct: 7   SEDLRSHAWYHGPLPRQDAERLLVSNGDFLIRDSISSPGDYVLSCFCAGGQPLHFKIIAV 66

Query: 263 HNRVR---------TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             R R              F NI  L+  +V +   V        T   +IRPV
Sbjct: 67  ALRPRRGIARTLYQLEQDQFDNIPALVRSYVGDRRKV-----SESTGAVIIRPV 115


>UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putative n=1
           Tax=Schistosoma mansoni RepID=C5J914_SCHMA
          Length = 708

 Score = 59.3 bits (142), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 34/102 (33%), Positives = 57/102 (55%), Gaps = 6/102 (5%)

Query: 198 RAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLSGRTAENEH 254
           + P ++ED   + W+HG ++ ++A+ +L   G    FLVR+S H PG YVLS  T E + 
Sbjct: 101 KYPLISEDPTTERWFHGKITGKEAEKMLLERGKPDCFLVRESVHRPGSYVLSVLTGE-QV 159

Query: 255 KHLILLDNHNRVR--TRDRTFSNISELIDYHVNNGMAVRSEG 294
            H+++    N +        FS++ ELID++ N  M  ++ G
Sbjct: 160 AHIMIHGKPNGMYDVGGGHQFSSLKELIDFYTNTPMVEKNGG 201



 Score = 47.0 bits (110), Expect = 9e-04,   Method: Compositional matrix adjust.
 Identities = 33/102 (32%), Positives = 53/102 (51%), Gaps = 11/102 (10%)

Query: 207 VGKVWYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +G  W+H NL+  +A+ LL  +G    FL R S  TPG + LS R  + E  H+ + +  
Sbjct: 4   IGGRWFHHNLTGLEAEKLLTLKGVSGSFLARPSHSTPGSFTLSVRRGD-EVTHIRIQNTE 62

Query: 264 NRVRTR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
             +       F+ +SEL+ Y++ N      EG+ RE + +LI
Sbjct: 63  EFLDLYGGEKFATLSELVTYYMEN------EGQLREKNGDLI 98


>UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein, partial n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E479E4
          Length = 926

 Score = 59.3 bits (142), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 44/140 (31%), Positives = 66/140 (47%), Gaps = 20/140 (14%)

Query: 168 ASTSNDGFTVPAP-PMRHRSSLH-------RQSFVSNCRAPTVTEDVVGKVWYHGNLSRE 219
           +S   D F+ P P P+R + SL        R+      + P+  EDV    W+HG +SRE
Sbjct: 77  SSIPEDHFSKPPPSPIRTKMSLQDMTPEDLRKLLEEEFKLPS--EDVRSHAWFHGGISRE 134

Query: 220 DAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL----ILLDNHN-----RVRTRD 270
            A+ L++  GDFLVR S   PG +VL+ R  +    H     ++L  H+     + +   
Sbjct: 135 KAEKLIRENGDFLVRDSISKPGNFVLTVR-WKGVSMHFVVNKVVLKAHSPYASVQYQFEK 193

Query: 271 RTFSNISELIDYHVNNGMAV 290
             F  I  LI ++V N   V
Sbjct: 194 ECFDAIPSLIKFYVGNCRPV 213


>UniRef50_UPI00006A1C30 UPI00006A1C30 related cluster n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI00006A1C30
          Length = 514

 Score = 58.2 bits (139), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 38/112 (33%), Positives = 51/112 (45%), Gaps = 14/112 (12%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
           D+    WYHG L R+DA+ LL + GDFL+R S  +PG YVLS   A  +  H  ++    
Sbjct: 22  DLRSHAWYHGPLPRQDAERLLVSNGDFLIRDSISSPGDYVLSCFCAGGQPLHFKIIAVAL 81

Query: 265 RVR---------TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           R R              F NI  L+  +V +   V        T   +IRPV
Sbjct: 82  RPRRGIARTLYQLEQDQFDNIPALVRSYVGDRRKV-----SESTGAVIIRPV 128


>UniRef50_Q18684 Protein T13H10.1, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q18684_CAEEL
          Length = 533

 Score = 58.2 bits (139), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 33/85 (38%), Positives = 51/85 (60%), Gaps = 5/85 (5%)

Query: 204 EDVVGK-VWYHGNLSREDAQALLKTEGDFLVRQSDHT---PGKYVLSGRTAENEH-KHLI 258
           E V+ K  WYHG L RED + LL   GDFLVR +D     P K+VLS      E  +H +
Sbjct: 8   EQVLAKEPWYHGLLPREDMKQLLTQRGDFLVRFTDPKVGEPRKFVLSVYVGVIEDIRHYV 67

Query: 259 LLDNHNRVRTRDRTFSNISELIDYH 283
           + +++N+     + FS+I++L++Y+
Sbjct: 68  IREHNNKFAVDKKWFSSIADLLNYY 92


>UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus CT10 oncogene homolog
           (avian)-like n=1 Tax=Ciona intestinalis
           RepID=UPI000180C238
          Length = 295

 Score = 58.2 bits (139), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 36/103 (34%), Positives = 54/103 (52%), Gaps = 15/103 (14%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEH-KHLILLDNHNRVR 267
           WY G +SR+D+Q  L  +  G FLVR S   PG YVLS   +EN    H I+    NR++
Sbjct: 14  WYFGMVSRKDSQNKLLHQKHGSFLVRDSTTCPGDYVLS--VSENSKVSHYIINKQENRLK 71

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
             D+ F ++ EL+D++  + +           +  LI P+P P
Sbjct: 72  IGDQMFDSMPELLDFYKVHYL----------DTTTLIEPIPKP 104


>UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186D8F4
          Length = 792

 Score = 57.8 bits (138), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 32/96 (33%), Positives = 55/96 (57%), Gaps = 8/96 (8%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRT-AENEH----KHLIL 259
           D+    WYHG++ R  A+ +L+++GDFLVR     PG +VLS +   +N H    K ++ 
Sbjct: 68  DLRSHAWYHGSIPRTRAEEILESDGDFLVRDCTSQPGNFVLSTKCKGQNLHFVINKVVLQ 127

Query: 260 LDN-HNRVRTR--DRTFSNISELIDYHVNNGMAVRS 292
            D  + R++ +  D  +  +S+LI Y+V +G  + S
Sbjct: 128 PDTVYERIQFQFEDEAYDTVSDLITYYVGSGKVISS 163


>UniRef50_A7RZ47 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7RZ47_NEMVE
          Length = 948

 Score = 57.4 bits (137), Expect = 6e-07,   Method: Compositional matrix adjust.
 Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 8/83 (9%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD-NHN----- 264
           W+HG ++ E A+ L++  G+FLVR+    PG Y ++ R  E E  HL +   NH+     
Sbjct: 58  WFHGKITAEYAEMLMRGAGEFLVREDPAMPGMYFIAVRNKEQETLHLAITKVNHSKGTRI 117

Query: 265 --RVRTRDRTFSNISELIDYHVN 285
             RV   D  F  I ELI ++++
Sbjct: 118 KYRVEDSDYMFDGIPELIQFYIS 140


>UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes related) tyrosine kinase
           (phosphoprotein NCP94), partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E47E92
          Length = 527

 Score = 57.0 bits (136), Expect = 8e-07,   Method: Compositional matrix adjust.
 Identities = 28/80 (35%), Positives = 44/80 (55%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD 270
           +YHG L R++ +ALL  +GDF+VR+     G+YVLS + A       I +++ N  R   
Sbjct: 207 FYHGALPRKETEALLVNDGDFVVREKSDAWGRYVLSAKHASKVRHFPIQINDENMYRLEG 266

Query: 271 RTFSNISELIDYHVNNGMAV 290
             F  + ELI + +N+   V
Sbjct: 267 DAFQTVGELIRFQLNSRQPV 286


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score = 56.2 bits (134), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 31/94 (32%), Positives = 49/94 (52%), Gaps = 3/94 (3%)

Query: 198 RAPTVTEDVVGKVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEH 254
           + P +  +   + W+HGNLS ++A+ L+      G FLVR+S   PG +VLS RT +   
Sbjct: 98  KQPLICAEPTTERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVT 157

Query: 255 KHLILLDNHNRVRTRDRTFSNISELIDYHVNNGM 288
             +I   +         +F  +SELID++  N M
Sbjct: 158 HVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPM 191



 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 30/103 (29%), Positives = 51/103 (49%), Gaps = 9/103 (8%)

Query: 211 WYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+H  +S  +A+ LL+ +G    FL R S   PG + LS R   NE  H+ + +N +   
Sbjct: 6   WFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRG-NEVTHIKIQNNGDFFD 64

Query: 268 TR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                 F+ + EL+ Y++ NG      G+    ++ L +P+ C
Sbjct: 65  LYGGEKFATLPELVQYYMENGELKEKNGQ----AIELKQPLIC 103


>UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID=Q7PSB5_ANOGA
          Length = 940

 Score = 55.8 bits (133), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 31/96 (32%), Positives = 49/96 (51%), Gaps = 8/96 (8%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI--LL 260
           + D+    WYHG + R+ A+ +++ EGDFLVR     PG YVL+ RT       +I  LL
Sbjct: 232 SRDLRSHAWYHGPIPRQRAEEIVQKEGDFLVRDCVSQPGNYVLTCRTKGPTLHFVINKLL 291

Query: 261 DNHNRVRTR------DRTFSNISELIDYHVNNGMAV 290
                V  R      D  +  + +LI ++V +G ++
Sbjct: 292 LQPETVYERVQYQFEDDAYDTVPDLITFYVGSGKSI 327


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score = 55.8 bits (133), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 33/81 (40%), Positives = 49/81 (60%), Gaps = 5/81 (6%)

Query: 211 WYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+  + S+  A ALL     +G FLVR+S+ TPG Y LS    + + KH  +  + +  R
Sbjct: 282 WFMADTSKAMASALLNMCGQDGAFLVRESESTPGSYSLS-VFYQGKLKHYKIKHDQDMYR 340

Query: 268 TRDR-TFSNISELIDYHVNNG 287
             +R TF++ISELI+YH +NG
Sbjct: 341 VSERHTFASISELIEYHKHNG 361


>UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorhabditis briggsae
           RepID=A8XFT2_CAEBR
          Length = 577

 Score = 55.5 bits (132), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 30/91 (32%), Positives = 54/91 (59%), Gaps = 12/91 (13%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAENEH------ 254
           +D+  + WYHG L RED +A+L+  GDFL+R ++   G   +YVLS    +NE       
Sbjct: 4   KDIHTEPWYHGLLPREDIKAMLRKTGDFLIRSTEPKQGEARQYVLSA--MQNEELEDAGV 61

Query: 255 KHLIL-LDNHNRVRTRDRTFSNISELIDYHV 284
           KH ++ ++ +N++    + F  I+ L++Y++
Sbjct: 62  KHYVMRVNANNQIFLETKGFETITSLVNYYM 92


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score = 55.5 bits (132), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 31/90 (34%), Positives = 47/90 (52%), Gaps = 3/90 (3%)

Query: 204 EDVVGKVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
           + + G+ W+ G +SR +A A+L   K EG FLVR+S+  PG+Y LS    E    + I  
Sbjct: 338 QGLEGEPWFRGRISRAEAAAMLQITKQEGCFLVRESETQPGEYTLSLSHNEGVRHYRIQH 397

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
                    +  F +I +LI+YH  NG  +
Sbjct: 398 IEGQYFVNENHRFDSIPQLIEYHKLNGGGI 427


>UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NNY7_BRUMA
          Length = 303

 Score = 55.1 bits (131), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 35/112 (31%), Positives = 59/112 (52%), Gaps = 7/112 (6%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEH-KHLIL 259
           ++T+DV G  +YHG + R D + LLK EGDFL+R+++ TPG+ VL+     N   +H ++
Sbjct: 14  SITDDVKGADYYHGLIPRTDIEPLLKKEGDFLLRKTELTPGEIVLAISVRHNNAVRHFMV 73

Query: 260 -LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
             D             ++S+LI Y+ +    + +  + R     L RP+  P
Sbjct: 74  NQDQDGSFYCEHHHEKSVSDLIQYYKSTKEPLSASSQAR-----LRRPIERP 120


>UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Takifugu rubripes
           RepID=UPI00016E7A57
          Length = 668

 Score = 55.1 bits (131), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 23/42 (54%), Positives = 28/42 (66%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLS 246
           D+    WYHG L RE  +ALL+ +GDFLVR S   PG YVL+
Sbjct: 18  DLKSHAWYHGPLGREAGEALLERDGDFLVRDSSSAPGDYVLT 59


>UniRef50_Q9BRG2 SH2 domain-containing protein 3A n=12 Tax=Eutheria
           RepID=SH23A_HUMAN
          Length = 576

 Score = 54.7 bits (130), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 26/49 (53%), Positives = 32/49 (65%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGR 248
           P   ED+ G+ WYHG LSR+ A+ALL+  GDFLVR S    G  V+S R
Sbjct: 4   PQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCR 52


>UniRef50_A9V4N6 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V4N6_MONBE
          Length = 363

 Score = 54.7 bits (130), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 42/130 (32%), Positives = 63/130 (48%), Gaps = 8/130 (6%)

Query: 16  GVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVT--AAREINPVVSRVIG 73
           G+     YLG +P   S+  M  E R  V  E IQ V+ TVGV     R+  P++ R + 
Sbjct: 34  GIVYPVKYLGKIPFAMSMRTMRFEDRTAVTREAIQLVSETVGVVDPVTRQATPLMKRTLV 93

Query: 74  E---VKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKN 130
           E       N  + I+++   I++I+   +I  H     SF A G +  +T    GYIAK+
Sbjct: 94  EDPVAMNLNVRLKISVTGLTIQVIETGEIIGTHIVPSISF-ATGDR-PNTYERIGYIAKD 151

Query: 131 KDGTDRRCHV 140
           +   +R CHV
Sbjct: 152 QR-NNRECHV 160


>UniRef50_Q4S6Q5 Chromosome undetermined SCAF14724, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4S6Q5_TETNG
          Length = 803

 Score = 54.3 bits (129), Expect = 6e-06,   Method: Compositional matrix adjust.
 Identities = 31/91 (34%), Positives = 52/91 (57%), Gaps = 8/91 (8%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGR---TAEN---EHKHL 257
           E++    WYHG + R+ A+ L++ +GDFL+R S  +PG YVL+ +   TA++     K +
Sbjct: 29  EELRSHAWYHGAIPRQVAENLVQRDGDFLIRDSLSSPGSYVLTSQWRNTAQHFKINKKVV 88

Query: 258 ILLDNHNRV--RTRDRTFSNISELIDYHVNN 286
            L + + RV  R     F ++  LI ++V N
Sbjct: 89  ALNEAYTRVEFRLEREGFDSVPALIRFYVGN 119


>UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio RepID=A2BDR6_DANRE
          Length = 635

 Score = 53.9 bits (128), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 35/116 (30%), Positives = 61/116 (52%), Gaps = 15/116 (12%)

Query: 179 APPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDH 238
           +PP + +  L ++  +S+C       ++    WYHG +  E +++L++ EGDFL+R S  
Sbjct: 25  SPPDKLKQELEKELKLSSC-------NLSSHGWYHGRIPWEVSESLVQQEGDFLIRDSLS 77

Query: 239 TPGKYVLSGRTAENEHKHLI---LL---DNHNRVR--TRDRTFSNISELIDYHVNN 286
           + G YVL+ R  +     LI   LL   D + RV+    + TF ++  L+  +V N
Sbjct: 78  SIGDYVLTCRWNQKALHFLITKVLLRSYDTYTRVQYILEEETFYSVPALVHSYVGN 133


>UniRef50_Q4SMI9 Chromosome 18 SCAF14547, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SMI9_TETNG
          Length = 609

 Score = 53.9 bits (128), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 24/42 (57%), Positives = 28/42 (66%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLS 246
           D+    WYHG L RE A+ALL+  GDFLVR S  TP  YVL+
Sbjct: 15  DLSSHAWYHGPLRREAAEALLERNGDFLVRDSSSTPRDYVLT 56


>UniRef50_B0WI58 Putative uncharacterized protein n=2 Tax=Culicini
           RepID=B0WI58_CULQU
          Length = 825

 Score = 53.9 bits (128), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 31/97 (31%), Positives = 51/97 (52%), Gaps = 8/97 (8%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENE-----HKHL 257
           + D+    WYHG + R+ A+ +++ EGDFLVR     PG YVL+ RT         +K L
Sbjct: 50  SRDLRSHAWYHGPIPRQRAEEIVQKEGDFLVRDCVSQPGNYVLTCRTKGPTLHFVINKLL 109

Query: 258 ILLDN-HNRVRTR--DRTFSNISELIDYHVNNGMAVR 291
           I  +  + RV+ +  D  +  + +LI ++V +    R
Sbjct: 110 IQPETVYERVQYQFEDDAYDTVPDLITFYVGSASGAR 146


>UniRef50_UPI00017B1E0A UPI00017B1E0A related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B1E0A
          Length = 680

 Score = 53.9 bits (128), Expect = 8e-06,   Method: Compositional matrix adjust.
 Identities = 24/42 (57%), Positives = 28/42 (66%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLS 246
           D+    WYHG L RE A+ALL+  GDFLVR S  TP  YVL+
Sbjct: 15  DLSSHAWYHGPLRREAAEALLERNGDFLVRDSSSTPRDYVLT 56


>UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76978_9METZ
          Length = 879

 Score = 53.5 bits (127), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 39/121 (32%), Positives = 52/121 (42%), Gaps = 28/121 (23%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEH----- 254
           P     V  + WYHG +SR++A  LLK  GDFLVR S             A+ EH     
Sbjct: 506 PEAHAGVEEEPWYHGEISRQEATGLLKKMGDFLVRYS-------------ADKEHYTLTV 552

Query: 255 -----KHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                KH I+  N    R     + +I  LID+H  N + V      R++   L +PV  
Sbjct: 553 KMEGIKHFIIQHNEEGFRFEGDPYPSIPMLIDHHFKNRLPVT-----RKSQAILRQPVKK 607

Query: 310 P 310
           P
Sbjct: 608 P 608


>UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, partial n=1 Tax=Tribolium
           castaneum RepID=UPI000175898D
          Length = 876

 Score = 53.5 bits (127), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 27/97 (27%), Positives = 49/97 (50%), Gaps = 10/97 (10%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL--- 259
           + D+    WYHG + R  A+ +++ EG FLVR     PG YVL+ RT + +  H ++   
Sbjct: 168 SRDLRSHAWYHGAIPRSRAEDIVREEGGFLVRDCTSQPGNYVLTCRT-KTQPLHFVINKI 226

Query: 260 ------LDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
                 +  H + +  +  F  + +LI ++V +G  +
Sbjct: 227 ILQPDTVYEHVQFQFEEDAFDTVPDLITFYVGSGKPI 263


>UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein activator 1 n=1 Tax=Ciona
           intestinalis RepID=UPI000052352E
          Length = 936

 Score = 53.1 bits (126), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 3/79 (3%)

Query: 208 GKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
           GK W+H  +++E+A +LL      G FL+R SD TPG YVL   T +   +  +     N
Sbjct: 226 GKEWFHAGITKEEAYSLLSAVDRSGSFLIRVSDSTPGDYVLYFFTGQYIQRFKLHRVGQN 285

Query: 265 RVRTRDRTFSNISELIDYH 283
           R     R + +I E+++++
Sbjct: 286 RFEMGGRCYGSIDEVVEHY 304



 Score = 43.9 bits (102), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 3/86 (3%)

Query: 211 WYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           WYHG L R  A+  L      G +LVR+S   PG YVLS  +      H  ++       
Sbjct: 58  WYHGKLDRRIAEERLLEVNVAGGYLVRESQKKPGSYVLSFLSENIGMTHFRIISVCGDFY 117

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSE 293
              R F  + +LI Y+ +    +  E
Sbjct: 118 IGGRQFECLEQLIAYYTHRSCLLEGE 143


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score = 52.8 bits (125), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 4/79 (5%)

Query: 208 GKVWYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
           GKVW+HGN+S+E+A   L  +GD   FL+R SD  PG Y LS R   N  +   +     
Sbjct: 234 GKVWFHGNVSKEEAAETLWKDGDIGGFLIRNSDKNPGDYSLSFR-GPNTIQRFRIQKQQR 292

Query: 265 RVRTRDRTFSNISELIDYH 283
           +     R ++++  ++D++
Sbjct: 293 QYVMGGRYYNSLDAIVDHY 311



 Score = 47.0 bits (110), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 39/135 (28%), Positives = 56/135 (41%), Gaps = 22/135 (16%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE---GDFLVRQSD 237
           P    + L  ++  +N  AP   E      WYHG L R+ A+  L      G +LVR+S+
Sbjct: 44  PFESYTELPEETVDANLTAPPENE------WYHGCLDRQSAELRLNAADKPGSYLVRESE 97

Query: 238 HTPGKYVLS--GRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGR 295
             PG YVLS  G+   N   H  +           R F  + ELI Y+ +    +++E  
Sbjct: 98  RKPGSYVLSYLGQRGIN---HFRVTAVCGDFYVGGRQFQTLPELIGYYTHISNILKNE-- 152

Query: 296 DRETSLNLIRPVPCP 310
                  L  P P P
Sbjct: 153 ------RLQYPAPPP 161


>UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein n=1 Tax=Brugia
           malayi RepID=A8Q5H2_BRUMA
          Length = 652

 Score = 52.8 bits (125), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 27/82 (32%), Positives = 49/82 (59%), Gaps = 4/82 (4%)

Query: 211 WYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+H  LS  +A+ LL  EG    +LVR+S  +PG++ +S + A+++  H+++    ++  
Sbjct: 140 WFHAGLSGPEAERLLLAEGKHGTYLVRESHSSPGQFAISVKAADDKVIHVMIYSKSDKFD 199

Query: 268 T-RDRTFSNISELIDYHVNNGM 288
                TFS ISEL++++  N M
Sbjct: 200 IGGGATFSTISELLEHYTRNPM 221


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score = 52.4 bits (124), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 26/75 (34%), Positives = 45/75 (60%), Gaps = 2/75 (2%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WY+G ++R DA+ LL  K EG FL+R S+ +PG + LS +  +      +L D  ++   
Sbjct: 60  WYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFL 119

Query: 269 RDRTFSNISELIDYH 283
               F++++EL++YH
Sbjct: 120 WVVKFNSLNELVEYH 134


>UniRef50_UPI000186DA97 tyrosine-protein kinase transforming protein FPS, putative n=1
           Tax=Pediculus humanus corporis RepID=UPI000186DA97
          Length = 850

 Score = 52.4 bits (124), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 34/89 (38%), Positives = 47/89 (52%), Gaps = 4/89 (4%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHT-PGKYVLSGRTAENEHKHLILLDN-H 263
           ++ + W+HG L RE+   LL+ EGDFLVR++      + VLS   A   HKH I+  N  
Sbjct: 481 LIDEEWFHGVLPREEVVRLLRHEGDFLVRETTRNDECQTVLS--VAWGGHKHFIVQTNLE 538

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRS 292
              R    +F  I ELI Y   +G+ V S
Sbjct: 539 GHFRFEGPSFPTIQELILYQYQSGLPVTS 567


>UniRef50_Q8AVM4 Sh2d3c-prov protein n=7 Tax=Euteleostomi RepID=Q8AVM4_XENLA
          Length = 676

 Score = 52.4 bits (124), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 30/93 (32%), Positives = 50/93 (53%), Gaps = 10/93 (10%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL--- 259
           + D     WYHG + RE +++L++  GDFL+R S  + G YVL+ R  +NE  H  +   
Sbjct: 31  SSDPRSHAWYHGRIPREVSESLVQRNGDFLIRDSLTSLGDYVLTCRW-KNESLHFKINKV 89

Query: 260 ----LDNHNRVRT--RDRTFSNISELIDYHVNN 286
                D++ R++      +F NI  L+ Y+V +
Sbjct: 90  MVKTSDSYTRIQYLFEQESFDNIPALVRYYVGS 122


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score = 52.4 bits (124), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 35/111 (31%), Positives = 57/111 (51%), Gaps = 8/111 (7%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKH 256
           P++     GK WY+G L+R  A+ +L     +GDFL+R S+  P  + +S + A  ++KH
Sbjct: 225 PSMDGKFGGKQWYYGKLTRHQAEMVLNQRGVDGDFLIRDSESMPNDFSISLK-ALYKNKH 283

Query: 257 LILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             +L N        R FS + +L++ H        SE  D+   L LI+P+
Sbjct: 284 FKVLLNDGFFCIGQRKFSTMEDLVE-HYKKAPIFTSEHGDK---LYLIKPL 330


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score = 52.4 bits (124), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 30/82 (36%), Positives = 49/82 (59%), Gaps = 5/82 (6%)

Query: 211 WYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+HGNLS ++A+ L+      G FLVR+S   PG +VLS RT E++  H+++  + N+  
Sbjct: 58  WFHGNLSGKEAERLILERGKNGSFLVRESQSKPGDFVLSVRT-EDKVTHVMIRWHENKYD 116

Query: 268 T-RDRTFSNISELIDYHVNNGM 288
               + F  + ELI+++  N M
Sbjct: 117 VGGGQKFGTLCELIEHYKRNPM 138


>UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun sequence n=2
           Tax=Chordata RepID=Q4RUN4_TETNG
          Length = 1136

 Score = 52.0 bits (123), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 25/45 (55%), Positives = 32/45 (71%), Gaps = 3/45 (6%)

Query: 208 GKVWYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLSGRT 249
           GKVWYHG++++++A  LL T G    FLVR SD+TPG Y L  RT
Sbjct: 356 GKVWYHGHITKKEAYNLLMTVGQVCSFLVRPSDNTPGDYSLFFRT 400



 Score = 51.2 bits (121), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 32/103 (31%), Positives = 48/103 (46%), Gaps = 11/103 (10%)

Query: 211 WYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           WYHG L R  A+  L+     G +L+R+SD  PG +VLS  +  N   H  ++       
Sbjct: 185 WYHGKLDRTIAEERLRQARNPGSYLIRESDRRPGSFVLSFLSMTNVVNHFRIIAMCGDYY 244

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
              R FS++S+LI Y+      ++ E         L+ PV  P
Sbjct: 245 IGGRRFSSLSDLIGYYSYVSCLLKGE--------KLLSPVAPP 279


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score = 52.0 bits (123), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 33/84 (39%), Positives = 49/84 (58%), Gaps = 6/84 (7%)

Query: 209 KVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAEN-EHKHLILLDNHN 264
           + W+HG +SR +A ALL   K EG FLVR+S+   G+Y LS    ++  H H+       
Sbjct: 300 EAWFHGRISRAEAAALLHVAKQEGCFLVRESESKVGEYSLSVSHGDSLRHYHIKKEGEEF 359

Query: 265 RVRTRDRTFSNISELIDYH-VNNG 287
            +  R R F +I +LI+YH +N+G
Sbjct: 360 YINDRHR-FPDICKLIEYHKLNSG 382


>UniRef50_UPI000192756A PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI000192756A
          Length = 295

 Score = 52.0 bits (123), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 24/75 (32%), Positives = 48/75 (64%), Gaps = 3/75 (4%)

Query: 211 WYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WYHG+++R   +++L  +  G FLVR S    G YVLS  +  N+  H I+ + +++ + 
Sbjct: 10  WYHGDITRPACESILMAQKPGLFLVRDSSTCKGGYVLS-VSENNKVSHYIITNKNSQYQI 68

Query: 269 RDRTFSNISELIDYH 283
            D+TF+++ E+++++
Sbjct: 69  GDQTFNDLPEIVEFY 83


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score = 51.6 bits (122), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 33/95 (34%), Positives = 52/95 (54%), Gaps = 7/95 (7%)

Query: 195 SNCRAPTVTEDVV---GKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRT 249
           SN  AP V    V      W+HG ++R DA+ LL  + +G FLVR+S + PG Y +    
Sbjct: 89  SNKAAPAVRHKEVKLTAMPWFHGKITRSDAEDLLTPRKDGLFLVRESTNYPGDYTMCVSF 148

Query: 250 A-ENEHKHLILLDNHNRVRTRDRTFSNISELIDYH 283
           A E EH  +I  DN   +   +  F N+++L++++
Sbjct: 149 AGEVEHYRVIFKDNKVTI-DEEEYFENLTKLVEHY 182


>UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group RepID=Q9VMJ4_DROME
          Length = 944

 Score = 51.6 bits (122), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 32/91 (35%), Positives = 49/91 (53%), Gaps = 8/91 (8%)

Query: 210 VWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRT-AENEH---KHLILLDN--H 263
            WYHG L R+ A+ +++ EGDFLVR     P  YVLS R+ A   H     L+L     +
Sbjct: 239 AWYHGALPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKAAVLHFVLNKLVLQPETVY 298

Query: 264 NRVRTR--DRTFSNISELIDYHVNNGMAVRS 292
            RV+ +  +  F  + +LI ++V +G  + S
Sbjct: 299 ERVQYQFEEDAFDTVPDLITFYVGSGKPISS 329


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score = 51.2 bits (121), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 7/99 (7%)

Query: 209 KVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           + WYHG + R + Q LL  +GDFLVR+S   PG YVLS   +    KH ++ +  N    
Sbjct: 526 QTWYHGAIPRLEVQQLLTKDGDFLVRKSQEKPG-YVLSVHWS-GACKHFLVQNKDNMYCL 583

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
              +F  I +LI  +  +   V      +++ + L RPV
Sbjct: 584 DGESFHTIPQLIQQYQTSQQHV-----TKKSEVVLRRPV 617


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score = 50.8 bits (120), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 5/87 (5%)

Query: 205 DVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
           D+  ++WYHG +SR DA+ LL    +  G FLVR S  T G+YVLS      ++ ++I  
Sbjct: 3   DLSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKKYHYIISR 62

Query: 261 DNHNRVRTRD-RTFSNISELIDYHVNN 286
                V  +D   F +  ELI YH   
Sbjct: 63  HPDGSVAIQDGAKFDSPIELIQYHTKK 89


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score = 50.8 bits (120), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 27/90 (30%), Positives = 50/90 (55%), Gaps = 3/90 (3%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKH 256
           P  + D   + WYHG++  ++A+ +L ++G    +LVR+S   PG++VL  + A    + 
Sbjct: 100 PVRSTDPTTERWYHGSIGAKEAERMLLSKGRLGSYLVRESQSQPGQFVLVVKCANGVQQV 159

Query: 257 LILLDNHNRVRTRDRTFSNISELIDYHVNN 286
           +I   N         +F+++ ELI+Y+V N
Sbjct: 160 IISCRNKKYEIKSGPSFASLQELIEYYVMN 189


>UniRef50_A2AK86 SH2 domain containing 3C (Fragment) n=4 Tax=Euteleostomi
           RepID=A2AK86_MOUSE
          Length = 236

 Score = 50.8 bits (120), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 30/97 (30%), Positives = 47/97 (48%), Gaps = 10/97 (10%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD- 261
           + D+    WYHG + RE ++ L++  GDFL+R S  + G YVL+ R   N+  H  +   
Sbjct: 54  STDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCR-WHNQALHFKINKV 112

Query: 262 --------NHNRVRTRDRTFSNISELIDYHVNNGMAV 290
                    H R      +F ++  L+ YHV +  AV
Sbjct: 113 VVKAGESYTHIRYLFEQESFDHVPALVRYHVGSRKAV 149


>UniRef50_A8WHN9 Novel protein similar to vertebrate breast cancer anti-estrogen
           resistance 3 (BCAR3) n=3 Tax=Danio rerio
           RepID=A8WHN9_DANRE
          Length = 841

 Score = 50.8 bits (120), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 28/86 (32%), Positives = 48/86 (55%), Gaps = 10/86 (11%)

Query: 210 VWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL-------ILLDN 262
            WYHG + R+ A+ L++ +GDFL+R S  +PG YVL+ +  +N  +H         + + 
Sbjct: 157 AWYHGAIPRQVAENLVQRDGDFLIRDSLSSPGNYVLTCQW-KNSPQHFKINKRVVAMNEA 215

Query: 263 HNRVRT--RDRTFSNISELIDYHVNN 286
           ++RV+       F +I  L+ Y+V N
Sbjct: 216 YSRVQYLFEKEGFDSIPALVRYYVGN 241


>UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activating protein n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B62FA
          Length = 879

 Score = 50.4 bits (119), Expect = 8e-05,   Method: Compositional matrix adjust.
 Identities = 34/105 (32%), Positives = 51/105 (48%), Gaps = 16/105 (15%)

Query: 211 WYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLS--GRTAENEHKHLILLDNHNR 265
           WYHG L R  A+  L+     G +LVR+SD  PG YVLS  GRT  N  +   +  ++  
Sbjct: 77  WYHGRLDRFTAEERLRDASRLGSYLVRESDRKPGSYVLSYLGRTGINHFRITAVCGDY-- 134

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
                R F+++ +L+ Y+ +    ++ E         LI P P P
Sbjct: 135 -YIGGRQFNSLMDLVAYYTHCSDLLKKE--------RLIHPTPPP 170


>UniRef50_A2BDR5 SH2 domain containing 3C (Fragment) n=4 Tax=Euteleostomi
           RepID=A2BDR5_DANRE
          Length = 140

 Score = 50.4 bits (119), Expect = 9e-05,   Method: Compositional matrix adjust.
 Identities = 34/114 (29%), Positives = 60/114 (52%), Gaps = 15/114 (13%)

Query: 179 APPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDH 238
           +PP + +  L ++  +S+C       ++    WYHG +  E +++L++ EGDFL+R S  
Sbjct: 33  SPPDKLKQELEKELKLSSC-------NLSSHGWYHGRIPWEVSESLVQQEGDFLIRDSLS 85

Query: 239 TPGKYVLSGRTAENEHKHLI---LL---DNHNRVR--TRDRTFSNISELIDYHV 284
           + G YVL+ R  +     LI   LL   D + RV+    + TF ++  L+  +V
Sbjct: 86  SIGDYVLTCRWNQKALHFLITKVLLRSYDTYTRVQYILEEETFYSVPALVHSYV 139


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score = 50.1 bits (118), Expect = 9e-05,   Method: Compositional matrix adjust.
 Identities = 29/114 (25%), Positives = 58/114 (50%), Gaps = 7/114 (6%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLSGRTAEN 252
           N   P+ +     + W+HG ++R+D++ +L   G+   FL+R+S+  PG + +S +  E 
Sbjct: 276 NSFTPSSSVGFYDRDWFHGRITRQDSEKILGCPGESGLFLIRESETMPGDFAVSVKAPE- 334

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
             KH  +  +  +     R F ++ +L+D++  + +    +G   E  L L RP
Sbjct: 335 RVKHFKVTRSDKKFCIGQRKFESLDDLVDHYKRSPIFSSDDG---ELKLYLTRP 385


>UniRef50_B7PEL7 Signal transduction protein lnk-realted, putative n=1 Tax=Ixodes
           scapularis RepID=B7PEL7_IXOSC
          Length = 553

 Score = 50.1 bits (118), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 35/110 (31%), Positives = 55/110 (50%), Gaps = 7/110 (6%)

Query: 211 WYHGNLSREDAQALLKTEGD-----FLVRQSDHTPGKYVLSGRTAENEHKHL-ILLDNHN 264
           W+HG LSR DA  L+  EG      FLVRQS+   G+ VL+    +   KHL + L+   
Sbjct: 401 WFHGTLSRSDAAQLVLREGPLGHGVFLVRQSETRKGECVLT-FNFQGRAKHLRMTLNPEE 459

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDD 314
           + R +   F  I +++++   + + + S G    T  + +   P PGS D
Sbjct: 460 QCRVQHLWFQTIFDMLEHFRVHPIPLESGGASDVTLTDFVLATPSPGSGD 509


>UniRef50_UPI00006A5E95 PREDICTED: similar to HrSH2 n=1 Tax=Ciona intestinalis
           RepID=UPI00006A5E95
          Length = 572

 Score = 50.1 bits (118), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 36/125 (28%), Positives = 61/125 (48%), Gaps = 11/125 (8%)

Query: 174 GFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLV 233
           G  VP  P   +S   +++   + ++   T+++   +WYH  L RE+AQA++  +GDFL+
Sbjct: 12  GNLVPTFP---QSVETQKNLYRDVKSSNNTKEISNCLWYHFKLRREEAQAMVVNDGDFLL 68

Query: 234 RQSDHTPGKYVLSGRTAENEHKHLI--LLDNHNRVRT------RDRTFSNISELIDYHVN 285
           RQS  +   YVL+ R         I   +  H+ V +          F +I  LI YH+ 
Sbjct: 69  RQSLSSVDDYVLTLRWNATVLHFKINKFVQRHDAVNSSTFFVFERAYFDSIYSLIMYHME 128

Query: 286 NGMAV 290
           N + +
Sbjct: 129 NQIPI 133


>UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3 n=43
           Tax=Euteleostomi RepID=BCAR3_HUMAN
          Length = 825

 Score = 50.1 bits (118), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 30/93 (32%), Positives = 54/93 (58%), Gaps = 10/93 (10%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKH------ 256
           +ED+    WYHG + R+ ++ L++ +GDFLVR S  +PG +VL+ +  +N  +H      
Sbjct: 146 SEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQW-KNLAQHFKINRT 204

Query: 257 -LILLDNHNRVRTR--DRTFSNISELIDYHVNN 286
            L L + ++RV+ +    +F +I  L+  +V N
Sbjct: 205 VLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGN 237


>UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eutheria
           RepID=C9JAB9_HUMAN
          Length = 174

 Score = 50.1 bits (118), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 27/98 (27%), Positives = 50/98 (51%), Gaps = 4/98 (4%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKH 256
           P++T    G  WY+G ++R  A+  L     EGDFL+R S+ +P  + +S + A+ ++KH
Sbjct: 74  PSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLK-AQGKNKH 132

Query: 257 LILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
             +           R FS + EL++++    +    +G
Sbjct: 133 FKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQG 170


>UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME
          Length = 954

 Score = 50.1 bits (118), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 31/88 (35%), Positives = 45/88 (51%), Gaps = 8/88 (9%)

Query: 211 WYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLS--GRTAENEHKHLILLDNHNR 265
           WYHG L R  A++ L+     G +LVR+SD  PG YVLS  GRT  N   H  +      
Sbjct: 84  WYHGRLDRYSAESRLRGSSKLGSYLVRESDRKPGSYVLSYYGRTGIN---HFRITAVCGD 140

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSE 293
                R F ++S+L+ Y+ +    ++ E
Sbjct: 141 FYIGGRQFISLSDLVGYYTSCSDLLKRE 168


>UniRef50_Q21055 Protein tyrosine phosphatase n=3 Tax=Caenorhabditis
           RepID=Q21055_CAEEL
          Length = 668

 Score = 50.1 bits (118), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 33/90 (36%), Positives = 47/90 (52%), Gaps = 7/90 (7%)

Query: 211 WYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           W+HGNL    A  LL+TE  G +L+R S H PG  V+S +T E +  HL +  + +  R 
Sbjct: 134 WWHGNLPASSANKLLQTEKNGTYLLRASQHIPGALVISAKT-EGQVVHLTIYQDPSTGRF 192

Query: 269 R---DRT-FSNISELIDYHVNNGMAVRSEG 294
               DRT F +   LID +  N +  + E 
Sbjct: 193 NIDGDRTKFQSAWLLIDSYSKNPIVEKGEA 222


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score = 49.7 bits (117), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 27/89 (30%), Positives = 51/89 (57%), Gaps = 6/89 (6%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGR-TAENEH 254
            P+ +    G+ WY+GN++R  A+  L     EGDFL+R S+ +P  + +S + + +N+H
Sbjct: 273 GPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKH 332

Query: 255 KHLILLDNHNRVRTRDRTFSNISELIDYH 283
             + L+DN   +    R F  + EL++++
Sbjct: 333 FKVQLVDNVYCI--GQRRFHTMDELVEHY 359


>UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE
          Length = 249

 Score = 49.7 bits (117), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 27/85 (31%), Positives = 49/85 (57%), Gaps = 4/85 (4%)

Query: 211 WYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKHL-ILLDNHNRVR 267
           WY  N SR+ AQ  L  +  G F++R S  +PG + +S R  EN+ +H  ++ D   R  
Sbjct: 58  WYKENTSRQSAQDELMCQPIGAFIIRGSQSSPGDFSISVR-HENDVQHFKVMRDRQGRYY 116

Query: 268 TRDRTFSNISELIDYHVNNGMAVRS 292
                F+++++L+DY+ +N ++ +S
Sbjct: 117 LWSEMFTSLNKLVDYYTHNSISKQS 141


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score = 49.7 bits (117), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 30/80 (37%), Positives = 46/80 (57%), Gaps = 8/80 (10%)

Query: 209 KVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLS-GRTAENEHKHLILLDNHNR 265
           K+WYHGN++RE  + +L  + +G FLVR S + PG Y L      + EH  +  L   N 
Sbjct: 44  KLWYHGNITREHTEKILSGQADGTFLVRDSTNFPGDYTLCMAFNGKVEHYRIYQL---NG 100

Query: 266 VRTRD--RTFSNISELIDYH 283
           + T D   TF N+++LI ++
Sbjct: 101 ILTCDHEETFDNLTQLIAHY 120


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score = 49.3 bits (116), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 34/112 (30%), Positives = 56/112 (50%), Gaps = 9/112 (8%)

Query: 211 WYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           W+ G L+R  AQ+ L     +EG FL+R S+     YVLS R+ +    + +L  + NR 
Sbjct: 69  WFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKVLQTDQNRF 128

Query: 267 RTR-DRTFSNISELIDYH----VNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
                R FS+++EL+DY+    +NN   + +  +    S   + P P  G +
Sbjct: 129 YVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPCKRNTLSTPALLPFPTIGWE 180



 Score = 40.8 bits (94), Expect = 0.059,   Method: Compositional matrix adjust.
 Identities = 26/81 (32%), Positives = 40/81 (49%), Gaps = 5/81 (6%)

Query: 211 WYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           WY+GN++R  A+ LL      +G FLVR S+    +Y +S R+        I   +    
Sbjct: 250 WYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISARSEGKVFHFRIQRSSIGAY 309

Query: 267 RTRDR-TFSNISELIDYHVNN 286
              DR +F+ + ELI Y+  N
Sbjct: 310 FVSDRISFATLGELISYYQRN 330


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score = 49.3 bits (116), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 28/76 (36%), Positives = 45/76 (59%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WY G +SRE A+ LL    EG+FLVR S+  PG   +S R  E  +KH  + +    ++ 
Sbjct: 301 WYFGRISRERAEDLLLHGREGEFLVRDSESNPGDLSISMRGIE-RNKHFKVQNVDGLLKI 359

Query: 269 RDRTFSNISELIDYHV 284
            +RTF +++ LI+++ 
Sbjct: 360 GNRTFVDMNALINHYT 375


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score = 49.3 bits (116), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 34/118 (28%), Positives = 59/118 (50%), Gaps = 15/118 (12%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKHL----I 258
           D+  + W+HGN+ R +A+ LL+    G FL+R+S+   G Y L+    ++  K +    I
Sbjct: 62  DLTNEPWFHGNIGRIEAENLLQYSEPGTFLIRESETIKGSYTLTMIQIKDGTKQISHFRI 121

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDDIE 316
             D+     T  R F  + +LI +++ N     S+G     + NL+ P P P  + +E
Sbjct: 122 NYDDGKYFITSARRFLGLHQLIQHYMQN-----SDG----LACNLVYPQPKPSIEYME 170


>UniRef50_UPI00015B58E2 PREDICTED: similar to signal transduction protein lnk-realted n=1
           Tax=Nasonia vitripennis RepID=UPI00015B58E2
          Length = 458

 Score = 49.3 bits (116), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 30/90 (33%), Positives = 47/90 (52%), Gaps = 7/90 (7%)

Query: 211 WYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL-ILLDNHN 264
           W+HG L R DA  L+     +  G FLVRQS+   G+YVL+    +   KHL + L +  
Sbjct: 270 WFHGTLPRSDAAQLVLHNATEGHGTFLVRQSETRKGEYVLTF-NFQGRAKHLRMTLTDQG 328

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
             R +  +F  I +++D+   N + + S G
Sbjct: 329 HCRVQHLSFPAIYDMLDHFRQNPIPLESGG 358


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score = 49.3 bits (116), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 32/92 (34%), Positives = 52/92 (56%), Gaps = 5/92 (5%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAEN 252
           SN  AP  + D     WYHG +SR D++A+L +   G FLVR+S+ + G+Y +S R    
Sbjct: 180 SNFIAPYNSLDKY--TWYHGKISRSDSEAILGSGITGSFLVRESETSIGQYTISVRHDGR 237

Query: 253 EHKHLILLDNHNRVR-TRDRTFSNISELIDYH 283
              + I +DN  ++  T++  F  + EL+ +H
Sbjct: 238 VFHYRINVDNTEKMFITQEVKFRTLGELVHHH 269


>UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y1_9METZ
          Length = 893

 Score = 48.9 bits (115), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 26/85 (30%), Positives = 47/85 (55%), Gaps = 7/85 (8%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD-----NHNR 265
           W++ N+ R++A+   K  GD+L+R S     +YVL+   A  + KH ++ +        +
Sbjct: 526 WFYPNMERKEAEEKCKNTGDYLIRYSSKQ-NRYVLTVCWA-GQGKHFVIQEAPDEQTKTK 583

Query: 266 VRTRDRTFSNISELIDYHVNNGMAV 290
            R   R+F ++ EL+D+HVN+   V
Sbjct: 584 YRFESRSFPSVRELLDFHVNSQTPV 608


>UniRef50_Q8N5H7 SH2 domain-containing protein 3C n=39 Tax=Amniota RepID=SH2D3_HUMAN
          Length = 860

 Score = 48.9 bits (115), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 29/95 (30%), Positives = 46/95 (48%), Gaps = 10/95 (10%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD--- 261
           D+    WYHG + RE ++ L++  GDFL+R S  + G YVL+ R   N+  H  +     
Sbjct: 214 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRW-RNQALHFKINKVVV 272

Query: 262 ------NHNRVRTRDRTFSNISELIDYHVNNGMAV 290
                  H +      +F ++  L+ YHV +  AV
Sbjct: 273 KAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAV 307


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score = 48.9 bits (115), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 27/76 (35%), Positives = 45/76 (59%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I  D   +V  
Sbjct: 262 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFV 321

Query: 268 TRDRTFSNISELIDYH 283
           T++  F+ ++EL+ +H
Sbjct: 322 TQEAKFNTLAELVHHH 337


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score = 48.9 bits (115), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 34/106 (32%), Positives = 52/106 (49%), Gaps = 5/106 (4%)

Query: 182 MRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHT 239
           MR + S       SN  AP   +D+    WYH N+SR  A+ LLK+  +G FLVR+S  +
Sbjct: 101 MRSQRSGKEGYAPSNYIAPF--KDINRNPWYHSNISRNTAEYLLKSGVDGSFLVRESLSS 158

Query: 240 PGKYVLSGRTAENEHKHL-ILLDNHNRVRTRDRTFSNISELIDYHV 284
           PG+Y ++ R       H  I  D         + F+ + +L+ +H 
Sbjct: 159 PGEYSITLRCDGKARTHYRINHDARGYFVAAGKFFATVEQLVAHHA 204


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score = 48.9 bits (115), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 33/81 (40%), Positives = 43/81 (53%), Gaps = 5/81 (6%)

Query: 211 WYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD-NHNRV 266
           WY G +SR +AQ+ L+    +G FLVR+S+ + G Y LS         + I  D N   +
Sbjct: 258 WYVGKMSRVEAQSKLQIFNLDGTFLVRESETSAGSYTLSVYFNGQPRNYRIQHDGNEYYI 317

Query: 267 RTRDRTFSNISELIDYHVNNG 287
            TR R    I ELIDYH  NG
Sbjct: 318 TTRHRQ-KTIKELIDYHKLNG 337


>UniRef50_C3XYL7 Putative uncharacterized protein n=2 Tax=Branchiostoma floridae
           RepID=C3XYL7_BRAFL
          Length = 296

 Score = 48.9 bits (115), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 29/83 (34%), Positives = 43/83 (51%), Gaps = 3/83 (3%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKHLI-LL 260
           +D  G  WY GN+ RE A A L+ +  G F+VR+S   PG Y LS RT      +LI   
Sbjct: 191 QDYRGAAWYKGNVPREMAMAELERQCAGAFMVRESGSNPGCYALSLRTMAGISNYLIGKT 250

Query: 261 DNHNRVRTRDRTFSNISELIDYH 283
           D    +    ++F ++  LI ++
Sbjct: 251 DKGYTIMGFGKSFPDLHTLIIHY 273


>UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS
          Length = 965

 Score = 48.5 bits (114), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 29/90 (32%), Positives = 47/90 (52%), Gaps = 10/90 (11%)

Query: 210 VWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-------LDN 262
            WYHG L R+ A+ +++ EGDFLVR     P  YVLS R+ +    H +L          
Sbjct: 240 AWYHGPLPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRS-KLAVLHFVLNKLVLQPETV 298

Query: 263 HNRVRTR--DRTFSNISELIDYHVNNGMAV 290
           + RV+ +  +  F  + +LI ++V +G  +
Sbjct: 299 YERVQYQFEEDAFDTVPDLITFYVGSGKPI 328


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score = 48.5 bits (114), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 27/76 (35%), Positives = 45/76 (59%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I  D   +V  
Sbjct: 273 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDPDGKVFV 332

Query: 268 TRDRTFSNISELIDYH 283
           T++  F+ ++EL+ +H
Sbjct: 333 TQEAKFNTLAELVHHH 348


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score = 48.5 bits (114), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 34/101 (33%), Positives = 54/101 (53%), Gaps = 10/101 (9%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I  D   +V  
Sbjct: 253 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFV 312

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
           T++  F+ ++EL+ +H     +V  EG    T   L+ P P
Sbjct: 313 TQEAKFNTLAELVHHH-----SVPHEGHGLITP--LLYPAP 346


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186ED21
          Length = 751

 Score = 48.5 bits (114), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 30/81 (37%), Positives = 44/81 (54%), Gaps = 5/81 (6%)

Query: 211 WYHGNLSREDAQAL---LKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+HG LSR+DA+ L   L +EG FLVR+S  +PG +VL+     +   + IL    +   
Sbjct: 9   WFHGKLSRDDAEKLIQDLNSEGGFLVRESFASPGDFVLTLLHNGDIVHYQILRHGEDAFF 68

Query: 268 TRD--RTFSNISELIDYHVNN 286
           + D    F  +  LI+YH  N
Sbjct: 69  SIDNEHIFHGLETLINYHQEN 89


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score = 48.5 bits (114), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 27/76 (35%), Positives = 45/76 (59%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I  D   +V  
Sbjct: 254 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFV 313

Query: 268 TRDRTFSNISELIDYH 283
           T++  F+ ++EL+ +H
Sbjct: 314 TQEAKFNTLAELVHHH 329


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score = 48.5 bits (114), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 27/76 (35%), Positives = 45/76 (59%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I  D+  +V  
Sbjct: 197 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISEDSDGKVYV 256

Query: 268 TRDRTFSNISELIDYH 283
           T +  F+ ++EL+ +H
Sbjct: 257 TAEAKFNTLAELVHHH 272


>UniRef50_Q9XXE5 Protein Y43C5B.2, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q9XXE5_CAEEL
          Length = 245

 Score = 48.5 bits (114), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 7/90 (7%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSD---HTPGKYVLSGR----TAENEHKHLILLDNH 263
           +YHG L RED + +LK  GDF++R S+    +P   +LS        E E KH ++    
Sbjct: 18  YYHGFLPREDVKTVLKNNGDFVIRISEPQAGSPRSNILSVMHCVPPMEEEIKHYVIKTKG 77

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           +++     +F +I E++++H+    +V+ +
Sbjct: 78  DKIFIEKVSFLSIPEMVEWHLTKKESVQKD 107


>UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=4 Tax=Endopterygota
           RepID=P18106-3
          Length = 475

 Score = 48.5 bits (114), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 49/168 (29%), Positives = 77/168 (45%), Gaps = 17/168 (10%)

Query: 129 KNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSL 188
           ++KD    RC     +   KL+D++  A+N      +   S  +D  T+    + +  + 
Sbjct: 39  QSKDLNALRCQE---KQKQKLVDMIKCALN--EVGCEELPSGCDDDLTLEQNFIENGYNN 93

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQS-DHTPGKYVLSG 247
            +Q  +S  R P   E+     W+HG L RE+   LL  +GDFLVR++  +   + VLS 
Sbjct: 94  EQQISLSTNR-PLYEEE-----WFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLS- 146

Query: 248 RTAENEHKHLIL-LDNHNRVRTRDRTFSNISELI--DYHVNNGMAVRS 292
               N HKH I+        R     F++I ELI   YH    + V+S
Sbjct: 147 -VCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKS 193


>UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QDY0_BRUMA
          Length = 384

 Score = 48.1 bits (113), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 28/77 (36%), Positives = 42/77 (54%), Gaps = 4/77 (5%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAENEHKHLILLDNHNRVR 267
           WYHG L R+D   LL  +G FLVR+++   G   + VLS +   ++  H I+     +V 
Sbjct: 13  WYHGLLPRKDINILLSKQGQFLVRETEIKKGEGLQLVLSVKW-NDKTMHFIIRHVDGKVF 71

Query: 268 TRDRTFSNISELIDYHV 284
              R F++I  LI YH+
Sbjct: 72  IEKRQFNSIHALIRYHL 88


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score = 48.1 bits (113), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 30/99 (30%), Positives = 51/99 (51%), Gaps = 8/99 (8%)

Query: 201 TVTEDVVGKV----WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEH 254
           T+  D  G++    W+HG +SRE A++LL  + +G FLVR+S H PG Y L     +   
Sbjct: 87  TLPRDASGQLIPMPWFHGKISRELAESLLMPREDGLFLVRESAHFPGDYTLCVCFQDQVD 146

Query: 255 KHLILLDNHNRVRTRDRTFSNISELIDYHVN--NGMAVR 291
            + +   N       +  FS++ EL+ ++    +G+  R
Sbjct: 147 HYRMQGKNGKLTIDEEVYFSSLEELVQHYEKDADGLCTR 185


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score = 48.1 bits (113), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 27/100 (27%), Positives = 55/100 (55%), Gaps = 7/100 (7%)

Query: 209 KVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL-ILLDNHNRVR 267
           + W+HG + R ++  LL+ +GDFL+R+S+++ G +VLS + A+ + +H  + + ++   R
Sbjct: 468 QTWFHGTIPRTESLRLLQQDGDFLLRESNNSLGDFVLSAK-ADGQVRHFKVQVTDNGMYR 526

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                F  +  LI +H       + E   + T+  L+ P+
Sbjct: 527 FEADQFPTVLNLISHHYQ-----KREPVTKRTNCLLLNPI 561


>UniRef50_A9USG6 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9USG6_MONBE
          Length = 251

 Score = 48.1 bits (113), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 33/97 (34%), Positives = 51/97 (52%), Gaps = 8/97 (8%)

Query: 211 WYHGNLSREDAQALLKTE----GDFLVRQS---DHTPGKYVLSGRTAENEHKHLILLDNH 263
           W+HG LS E+A+  LK +    GDFL+R S   +H    +VLS R++ ++  H++L+   
Sbjct: 23  WFHGCLSSEEAERRLKRDDSALGDFLIRLSHNEEHGGNHFVLSCRSSPSKVTHVVLIGEA 82

Query: 264 NRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
                +  +TF  I ELI   +      R+   DRET
Sbjct: 83  GSWGLSFAKTFQTIQELITETMKGDAIDRAAIADRET 119


>UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=Neoptera
           RepID=Q17DJ2_AEDAE
          Length = 564

 Score = 48.1 bits (113), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 45/156 (28%), Positives = 74/156 (47%), Gaps = 19/156 (12%)

Query: 167 NASTSNDGFTVPAPPMRHRSSLHRQSFVSNC--------RAPTVTEDVVGKV----WYHG 214
           N S  N   T PAP +  R    R S  SN         +A  V  D+   +    W+HG
Sbjct: 363 NQSALNAVPTKPAPELPPRREEGRISSSSNFELTEGDLEQAHEVDTDLTAMMREYPWFHG 422

Query: 215 NLSREDAQAL-----LKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL-ILLDNHNRVRT 268
            L+R +A  L     L + G FLVRQS+   G++VL+    + + KHL + L++  + R 
Sbjct: 423 TLARSEAAQLVLHNGLSSHGVFLVRQSETRKGEFVLT-FNFQGKAKHLRMTLNDLGQCRV 481

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
           +   F +I+E++++   + + + S G    T  N +
Sbjct: 482 QHLWFPSITEMLEHFRQHPIPLESGGTADVTLTNFV 517


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score = 48.1 bits (113), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 32/94 (34%), Positives = 49/94 (52%), Gaps = 21/94 (22%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVL---------SGRTAENEHKHLIL 259
           W+HG +SREDA+ LL     G FLVR+S + PG Y L         + R   NE K L+ 
Sbjct: 109 WFHGRISREDAEKLLTPPKNGRFLVRESQNYPGDYTLCVSYDGRVENYRVRRNE-KGLVT 167

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVN--NGMAVR 291
           +D+       D  F N+ +L++++    +G+  R
Sbjct: 168 VDD-------DEYFDNLIKLVEHYQKEADGLCTR 194


>UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=O01325_CAEEL
          Length = 474

 Score = 48.1 bits (113), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 28/85 (32%), Positives = 50/85 (58%), Gaps = 2/85 (2%)

Query: 212 YHGNLSREDAQALLKTEGDFLVRQSDHTP-GK-YVLSGRTAENEHKHLILLDNHNRVRTR 269
           YHG +SRE+++ L++++G+FL+R+++ T  G+  VLS    E  H  ++   N+     +
Sbjct: 92  YHGYMSREESEKLVRSQGEFLLRKTELTKRGEVVVLSVFWDEGVHHLVVEKANNGLYYLK 151

Query: 270 DRTFSNISELIDYHVNNGMAVRSEG 294
           +  F NIS+L+ YH     +V   G
Sbjct: 152 EFCFENISDLVRYHHQTRASVYKSG 176


>UniRef50_UPI000180B456 PREDICTED: similar to SH2 domain-containing protein 4B n=1
           Tax=Ciona intestinalis RepID=UPI000180B456
          Length = 537

 Score = 47.8 bits (112), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 31/89 (34%), Positives = 51/89 (57%), Gaps = 17/89 (19%)

Query: 205 DVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL--- 259
           DV+   W+HG +SR DA++LL  + E DFL+R SD   G Y LS + AE+  KH ++   
Sbjct: 420 DVIIPTWFHGIISRSDAESLLCSRPERDFLIRLSDKIWG-YALSYK-AEDRVKHFLIDAS 477

Query: 260 -----LDNHNRVRTRDRTFSNISELIDYH 283
                   ++++R       +++EL++YH
Sbjct: 478 EGSYHFFGNDQIR-----HESLAELVEYH 501


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score = 47.8 bits (112), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 28/84 (33%), Positives = 46/84 (54%), Gaps = 9/84 (10%)

Query: 209 KVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAEN-----EHKHLIL 259
           + W+  N+SR +A   L     T+G FLVR+S+ TPG Y LS R  +N     +H  +  
Sbjct: 114 EAWFFKNISRNEATRRLMAPGNTQGSFLVRESETTPGSYSLSMRDFDNNGDGVKHYRIRN 173

Query: 260 LDNHNRVRTRDRTFSNISELIDYH 283
           +DN     T   +F+++ EL+ ++
Sbjct: 174 MDNGGFYITTKISFNSLKELVQHY 197


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score = 47.8 bits (112), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 27/76 (35%), Positives = 43/76 (56%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I      +V  
Sbjct: 173 WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYV 232

Query: 268 TRDRTFSNISELIDYH 283
           T +  FS ++EL+ +H
Sbjct: 233 TAESRFSTLAELVHHH 248


>UniRef50_UPI0000DB7594 PREDICTED: similar to CG9098-PA, isoform A n=1 Tax=Apis mellifera
           RepID=UPI0000DB7594
          Length = 797

 Score = 47.8 bits (112), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 30/102 (29%), Positives = 49/102 (48%), Gaps = 21/102 (20%)

Query: 205 DVVGKVWYHGNL---SREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
           D+    WYHG+     R+ A+A +  +GDFLVR     PG YVL+ R  + +  H ++  
Sbjct: 142 DLRSHAWYHGSTLRGGRKGAEAEVPNDGDFLVRDCASQPGNYVLTVRW-KGQPLHFVI-- 198

Query: 262 NHNRV-------------RTRDRTFSNISELIDYHVNNGMAV 290
             NRV             +  D  F  +++LI ++V +G  +
Sbjct: 199 --NRVVIQPETVYERAQYQFEDEAFDTVADLITFYVGSGRPI 238


>UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, partial n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793081
          Length = 770

 Score = 47.8 bits (112), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 34/105 (32%), Positives = 50/105 (47%), Gaps = 9/105 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHT-PGKYVLSGRTAENEHKHLIL-LDNH 263
           ++ + W+HG L RE+   LL  EGDFLVR++      + VLS       HKH I+   + 
Sbjct: 532 LIEEEWFHGVLPREEVVRLLTKEGDFLVRETTRNDENQTVLS--VCWGGHKHFIVQTTSE 589

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
              R    +F  I ELI Y   + + V S      +   L +P+P
Sbjct: 590 GEFRFEGPSFPTIQELITYQYQSALPVTS-----RSGAILRQPIP 629


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score = 47.4 bits (111), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 29/79 (36%), Positives = 44/79 (55%), Gaps = 6/79 (7%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHK---HLILLDNHNR 265
           W+ G ++RE A+ LL  +  G FLVR+S + PG Y L   + +N  K   + ++  N NR
Sbjct: 32  WFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVISTNDNR 91

Query: 266 VRT-RDRTFSNISELIDYH 283
           V    D  F N+ ELI ++
Sbjct: 92  VTVDEDAFFPNLIELIKHY 110


>UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4I2_DROPE
          Length = 431

 Score = 47.4 bits (111), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 32/107 (29%), Positives = 53/107 (49%), Gaps = 9/107 (8%)

Query: 207 VGKVWYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           V + W+H  +S  +A+ LL+ EG    FL R S   PG + LS R   NE  H+ + +N 
Sbjct: 323 VRRKWFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRG-NEVTHIKIQNNG 381

Query: 264 NRVRTR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           +         F+ + EL+ Y++ NG      G+    ++ L +P+ C
Sbjct: 382 DFFDLYGGEKFATLPELVQYYMENGELKEKNGQ----AIELKQPLIC 424


>UniRef50_B3RQY3 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RQY3_TRIAD
          Length = 654

 Score = 47.4 bits (111), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 50/176 (28%), Positives = 77/176 (43%), Gaps = 26/176 (14%)

Query: 105 FSFFSFGAQGQ--KGTDTELMFG---YIAKNKDGTDRRCHVV----------FIEDVHKL 149
           FS F  G  GQ  K   TE++      ++++   T  RCH            F+  + K 
Sbjct: 374 FSVFRVGKYGQQLKTNYTEMIQSSPEVMSQDFASTRSRCHTTSELPRSRSLSFLRGLSKR 433

Query: 150 IDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGK 209
            D + T     T  + AN S    G  + AP  R R+   R  F  + +  +V +    +
Sbjct: 434 KDTVAT-----TPSSPANDSPVLSGPLLHAPEPRARTGTMR--FTRDKKGISVKDLSYDQ 486

Query: 210 VWYHGNLSREDAQALLK----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
            W+H ++SR  A  +L     ++G FL+R+S  TPG  VLS    +  H   I+LD
Sbjct: 487 PWFHTSISRIQAVDILTDKGTSDGLFLIRESTSTPGSLVLSLCHKKKVHHIQIVLD 542


>UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n=1 Tax=Taeniopygia guttata
           RepID=UPI000194DE57
          Length = 699

 Score = 47.0 bits (110), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 29/82 (35%), Positives = 46/82 (56%), Gaps = 5/82 (6%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR--V 266
           W HG +SR +A+ LL  K  G FLVR S   PG Y+L+ R       ++I +  + R  +
Sbjct: 590 WLHGMISRREAENLLIDKPLGSFLVRISQSRPG-YILTYRGEGRCRHYMIQVQPNARYVI 648

Query: 267 RTRDRTFSNISELIDYHVNNGM 288
              DR  ++++EL+ YH + G+
Sbjct: 649 LGEDRAHASLTELVRYHQSVGI 670


>UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=Culicidae
           RepID=B0X2Z7_CULQU
          Length = 591

 Score = 47.0 bits (110), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 29/100 (29%), Positives = 55/100 (55%), Gaps = 7/100 (7%)

Query: 211 WYHGNLSREDAQAL-----LKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL-ILLDNHN 264
           W+HG L+R +A  L     + + G FLVRQS+   G++VL+    + + KHL + L++  
Sbjct: 439 WFHGTLARSEAAQLVLHNGISSHGVFLVRQSETRKGEFVLTF-NFQGKAKHLRMTLNDLG 497

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
           + R +   F +I+E++++   + + + S G    T  N +
Sbjct: 498 QCRVQHLWFPSITEMLEHFRQHAIPLESGGTADVTLTNFV 537


>UniRef50_UPI00019255F9 PREDICTED: similar to V-crk sarcoma virus CT10 oncogene homolog n=1
           Tax=Hydra magnipapillata RepID=UPI00019255F9
          Length = 249

 Score = 47.0 bits (110), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 30/86 (34%), Positives = 52/86 (60%), Gaps = 5/86 (5%)

Query: 202 VTEDVV-GKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
           +TE+V+ G  WYH  +SRE+AQ LL     G FLVR+      +YVLS  + + +  H I
Sbjct: 1   MTEEVLQGFNWYHNTISREEAQTLLNGCKLGSFLVRRRKGVSNEYVLS-VSEKQKISHYI 59

Query: 259 LLD-NHNRVRTRDRTFSNISELIDYH 283
           ++D N    +  ++ F++I+ +I+++
Sbjct: 60  IMDVNGMYFKIGEQRFADIASIIEFY 85


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score = 47.0 bits (110), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 2/76 (2%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           W+HG + RE+A+ LLK   +G FLVR+S + PG Y L     E    + I    +     
Sbjct: 378 WFHGRIKREEAENLLKPREDGLFLVRESTNFPGDYTLCVCFNEKVEHYRIKYAENKLTID 437

Query: 269 RDRTFSNISELIDYHV 284
            D  F N+ +L++++ 
Sbjct: 438 DDEYFDNLGQLVEHYT 453


>UniRef50_Q9N4T6 Putative uncharacterized protein n=1 Tax=Caenorhabditis elegans
           RepID=Q9N4T6_CAEEL
          Length = 448

 Score = 47.0 bits (110), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 34/119 (28%), Positives = 56/119 (47%), Gaps = 34/119 (28%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL-------DNH 263
           +YHG L RED Q+ L+  GDFL+R S+      V+ G    N    L L+       ++ 
Sbjct: 79  FYHGFLPREDLQSTLQNPGDFLLRVSE------VVEGENKVNREIILSLIPIQEEGKEDE 132

Query: 264 NRVRTRD---------------RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           +++RTR+               R+F +I ELI+Y++ N  +  S       +  L+ P+
Sbjct: 133 DKIRTRNVVIKRAGYLFFCETTRSFDSIFELINYYMKNTGSCSS------ATFQLLNPI 185


>UniRef50_A8WMP8 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8WMP8_CAEBR
          Length = 284

 Score = 47.0 bits (110), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 28/93 (30%), Positives = 46/93 (49%), Gaps = 12/93 (12%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAENE--------- 253
           ++ + +YHG L REDA ALL   GDFL+R S+ T G    ++LS  T +           
Sbjct: 11  IIREGYYHGLLPREDAAALLTQNGDFLIRISEPTDGAEQNFILSCMTDDKSKSNDENPGM 70

Query: 254 HKHLILLDNHNRVRTRDRTFSNISELIDYHVNN 286
              ++   N   +   + +F  I +L+++H  N
Sbjct: 71  QNFVVGFQNGRYLVAENHSFPTIEKLVEFHKKN 103


>UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS
          Length = 155

 Score = 46.6 bits (109), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 31/103 (30%), Positives = 51/103 (49%), Gaps = 9/103 (8%)

Query: 211 WYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+H  +S  +A+ LL+ EG    FL R S   PG + LS R   NE  H+ + +N +   
Sbjct: 6   WFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRG-NEVTHIKIQNNGDFFD 64

Query: 268 TR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                 F+ + EL+ Y++ NG      G+    ++ L +P+ C
Sbjct: 65  LYGGEKFATLPELVQYYMENGELKEKNGQ----AIELKQPLIC 103


>UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9VPU1_DROME
          Length = 548

 Score = 46.6 bits (109), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 30/112 (26%), Positives = 53/112 (47%), Gaps = 8/112 (7%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKH 256
           P    ++ GK WY+G ++R     +L     +GDFL+R S+   G Y +S + A   +KH
Sbjct: 437 PIERPNLAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMGDYSVSLK-APGRNKH 495

Query: 257 LILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
             +    N      R F ++ +L+D++    +    +G      L L+R +P
Sbjct: 496 FRVHVEQNMYCIGQRKFHSLDQLVDHYQRAPIYTNKQGE----KLYLVRSLP 543


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score = 46.6 bits (109), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 32/101 (31%), Positives = 51/101 (50%), Gaps = 8/101 (7%)

Query: 211 WYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           WYHGNL+R  A+ALL +   +G +L+R S+ T G Y LS R A++  KH  +       +
Sbjct: 35  WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVR-AKDSVKHFHVEYTGYSFK 93

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
                FS++ + + +  N  +     G +  T + L  P P
Sbjct: 94  FGFNEFSSLKDFVKHFANQPLI----GSETGTLMVLKHPYP 130


>UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O97034_9METZ
          Length = 1283

 Score = 46.6 bits (109), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 31/93 (33%), Positives = 49/93 (52%), Gaps = 9/93 (9%)

Query: 207 VGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHT----PGKYVLSGRTAENEHKHL-I 258
           +GK W+H NLSR +A+ +LK    +G FL+R S+         Y +S R AE + KH  I
Sbjct: 651 LGKAWFHENLSRSEAEEMLKKVRMDGAFLIRPSEQNTKAGQKNYAISFR-AEGKVKHCRI 709

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
            +D   +       F +++EL+ Y+  N +  R
Sbjct: 710 EVDESGQYCIGSAIFDSLTELVQYYEANPLYRR 742


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score = 46.6 bits (109), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 27/101 (26%), Positives = 52/101 (51%), Gaps = 8/101 (7%)

Query: 211 WYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+ G + R  A+ +L   + +G FL+R+S+  PG + LS +   +     +L D   +  
Sbjct: 60  WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
                F++++EL+DYH +  ++     R+++  L  I  VP
Sbjct: 120 LWVVKFNSLNELVDYHRSTSVS-----RNQQIFLRDIEQVP 155


>UniRef50_UPI00019269FE PREDICTED: similar to protein tyrosine phosphatase, non-receptor
           type 11 n=1 Tax=Hydra magnipapillata RepID=UPI00019269FE
          Length = 544

 Score = 46.6 bits (109), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 37/162 (22%), Positives = 75/162 (46%), Gaps = 19/162 (11%)

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVG----------KV 210
           T D ++     NDGF      + +      +    N ++  +TE ++           + 
Sbjct: 64  TNDGESFGLYENDGFASVPDLIEYYQHNPSKFLDQNNKSVELTEPLIDDSENDPGLSQEK 123

Query: 211 WYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLSGRTAENEHKHLILLDN--HNR 265
           W+ G + R +A+ +LK  G+   +LVR+S   PG +VLS R   +  + L++  +   + 
Sbjct: 124 WFFGEIGRGEAELILKQRGEHGSYLVRESRTQPGNFVLSVRHHNSVIEFLLIYSDGAFDI 183

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             T+   F  ++ LI+Y + N +      +D + +++LI P+
Sbjct: 184 ANTKRLKFPTMTHLINYFITNPLI----HKDSDQAIHLIEPL 221


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score = 46.6 bits (109), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 21/40 (52%), Positives = 28/40 (70%), Gaps = 3/40 (7%)

Query: 210 VWYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLS 246
            W+HG +SREDA+ +L+ EG    FLVR+S  + G YVLS
Sbjct: 8   CWFHGKISREDAEEILRREGSDGVFLVRESSSSEGDYVLS 47


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score = 46.6 bits (109), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 4/76 (5%)

Query: 182 MRHRSSL-HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD---FLVRQSD 237
           M H   L  +   V   + P    D   + W+HG+LS ++A+ LL  +G    FLVR+S 
Sbjct: 82  MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQ 141

Query: 238 HTPGKYVLSGRTAENE 253
             PG +VLS RT +++
Sbjct: 142 SHPGDFVLSVRTGDDK 157


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 28/76 (36%), Positives = 43/76 (56%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +  +G FLVR S+ +PG   +S R     + + I   +  +V  
Sbjct: 187 WYHGPISRNAAEYLLSSGIDGSFLVRDSESSPGHRSISLRFDGRVYHYRISSGSDGKVFV 246

Query: 268 TRDRTFSNISELIDYH 283
           T +  FS I+EL+ +H
Sbjct: 247 TTESKFSTIAELVHHH 262


>UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus gallus
           RepID=Q5ZM15_CHICK
          Length = 431

 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 25/67 (37%), Positives = 39/67 (58%), Gaps = 3/67 (4%)

Query: 190 RQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLS 246
           + S V   + P   +D   + WYHG+L+ ++A+ LL  +G    FLVR+S   PG +VLS
Sbjct: 89  KNSNVIELKYPLNCQDPTSERWYHGHLTGKEAEKLLTEKGKPGSFLVRESQSKPGDFVLS 148

Query: 247 GRTAENE 253
             T E++
Sbjct: 149 VLTNEDK 155


>UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogaster subgroup
           RepID=SHARK_DROME
          Length = 939

 Score = 46.2 bits (108), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 23/39 (58%), Positives = 26/39 (66%), Gaps = 3/39 (7%)

Query: 211 WYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLS 246
           WYHGNLSRE A  LLK    +G FLVR+S    G +VLS
Sbjct: 10  WYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLS 48


>UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7P6T2_IXOSC
          Length = 702

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 25/93 (26%), Positives = 45/93 (48%), Gaps = 10/93 (10%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL--- 259
           + D+    WYHG + R+ A+ L+  +G FLVR     PG YVL+    +    H ++   
Sbjct: 20  SRDMRSHAWYHGTIPRQRAEELMTADGGFLVRDCVSRPGDYVLTC-CWKGAPLHFVINKV 78

Query: 260 ----LDNHNRVRTR--DRTFSNISELIDYHVNN 286
                  + R++ +  D  F  + +L+ ++V N
Sbjct: 79  VLQPYTVYERIQYQFEDDCFDTVPDLVTFYVGN 111


>UniRef50_UPI00015B5D64 PREDICTED: similar to LD41184p n=1 Tax=Nasonia vitripennis
           RepID=UPI00015B5D64
          Length = 858

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 30/93 (32%), Positives = 49/93 (52%), Gaps = 11/93 (11%)

Query: 205 DVVGKVWYHGNL---SREDAQALLKTEGDFLVRQSDHTPGKYVLSGR-TAENEH---KHL 257
           D+    WYHG+     R+ A+A +  +GDFLVR     PG YVLS R   +  H     L
Sbjct: 162 DLRSYAWYHGSSLPGGRKGAEAEIPNDGDFLVRDCSSQPGNYVLSVRHKGQALHFVINKL 221

Query: 258 ILLDN--HNRVRTR--DRTFSNISELIDYHVNN 286
           +L  +  + RV+ +  D  F  +++L+ ++V +
Sbjct: 222 VLQPDTVYERVQYQLEDEAFDTVADLVTFYVGS 254


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 4/76 (5%)

Query: 182 MRHRSSLHRQSF-VSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD---FLVRQSD 237
           M H   L  ++  V   + P    D   + W+HG+LS  +A+ LL  +G    FLVR+S 
Sbjct: 82  MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGREAEKLLTEKGKNGSFLVRESQ 141

Query: 238 HTPGKYVLSGRTAENE 253
             PG +VLS RT +++
Sbjct: 142 SHPGDFVLSVRTGDDK 157


>UniRef50_UPI0000523E1B PREDICTED: similar to Crk-like protein n=1 Tax=Ciona intestinalis
           RepID=UPI0000523E1B
          Length = 322

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 31/101 (30%), Positives = 56/101 (55%), Gaps = 13/101 (12%)

Query: 209 KVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           ++WY G+L R  A+ +L+  +EG FLVR S    G +VLS +  E E  H I+   H+++
Sbjct: 12  QIWYFGSLERIVAEQILQPTSEGTFLVRNSKSILGDFVLSVKQKE-EVIHYIIRREHSKL 70

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             ++  F ++  L++++  + +    EGR       LI+P+
Sbjct: 71  VLKNHVFLSMVTLLEHYKTHFVG---EGR-------LIKPM 101


>UniRef50_O44235 HrSH2 protein n=1 Tax=Halocynthia roretzi RepID=O44235_HALRO
          Length = 867

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 17/44 (38%), Positives = 31/44 (70%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGR 248
           D+    W+HG + R+ A+ L++ EGDFL+R+S +  G++VL+ +
Sbjct: 45  DIRSYAWFHGRMPRDIAEDLIRREGDFLIRESVNNAGEFVLTCK 88


>UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
            RepID=UPI000186E930
          Length = 1195

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 26/88 (29%), Positives = 52/88 (59%), Gaps = 5/88 (5%)

Query: 209  KVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR- 265
            + WYHG+++R +A+ LL++  EG +LVR S+     Y LS ++A+      I +DN++  
Sbjct: 1092 QTWYHGSITRVEAEDLLRSLKEGSYLVRNSESAKQDYSLSLKSAKGFMHMRIQIDNNSGQ 1151

Query: 266  --VRTRDRTFSNISELIDYHVNNGMAVR 291
              +    + F++I ++I ++  N + +R
Sbjct: 1152 FILGQFSKPFNSIPDMIRHYSVNKLPIR 1179


>UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2IB48_CHAVR
          Length = 1322

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 28/79 (35%), Positives = 42/79 (53%), Gaps = 4/79 (5%)

Query: 208 GKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
           GK WYH  L R  A+ +LK   ++G FLVRQ+      Y +S R AE + KH I+     
Sbjct: 669 GKPWYHEKLDRTRAEDMLKRIPSDGAFLVRQNGVDTNSYAISFR-AEGKIKHCIIKQEGR 727

Query: 265 RVRTRDRTFSNISELIDYH 283
                +  F ++ EL++Y+
Sbjct: 728 LFTIGNAQFESLVELVNYY 746


>UniRef50_UPI0000612FE6 UPI0000612FE6 related cluster n=1 Tax=Bos taurus
           RepID=UPI0000612FE6
          Length = 689

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 27/90 (30%), Positives = 49/90 (54%), Gaps = 7/90 (7%)

Query: 211 WYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHN 264
           W+HG LSR  A  L+     +  G F++RQS+  PG+YVL+    + + KHL L L+ H 
Sbjct: 459 WFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLT-FNFQGKAKHLRLSLNGHG 517

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
           +   +   F ++ +++ +   + + + S G
Sbjct: 518 QCHVQHLWFQSVLDMLRHFHTHPIPLESGG 547


>UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5M9_MONBE
          Length = 392

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 28/80 (35%), Positives = 44/80 (55%), Gaps = 6/80 (7%)

Query: 211 WYHGNLSREDAQALLKT----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           + HG +SRE+  AL+++    EG FLVR+S  TPG Y LS   A+ + +H  +       
Sbjct: 30  YMHGKISREEVDALVRSNGFSEGLFLVRESARTPGDYALS-VVAQGKLQHFKISRKTGLY 88

Query: 267 RTRDRT-FSNISELIDYHVN 285
           R  D   F ++ EL+ ++ N
Sbjct: 89  RIDDGPGFGSLDELVQFYRN 108


>UniRef50_UPI00017925DF PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Acyrthosiphon
           pisum RepID=UPI00017925DF
          Length = 555

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 11/102 (10%)

Query: 209 KVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENE-HKHLILLDNHNR 265
           + WYHG ++R +A+  L  + EG +LVR +    G Y LS ++A+   H  +   +  N 
Sbjct: 455 QCWYHGPMNRLEAEKALHGQKEGTYLVRGNK---GSYALSIKSAKGFIHMRITQSEERNY 511

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           +   DR F  I +LI ++  N +  +         + LIRP+
Sbjct: 512 LGQSDRPFETIPDLIKHYTLNKLPAKG-----AEHVGLIRPL 548


>UniRef50_Q4SW52 Chromosome undetermined SCAF13690, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SW52_TETNG
          Length = 338

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 29/78 (37%), Positives = 42/78 (53%), Gaps = 6/78 (7%)

Query: 210 VWYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEH-KHLILLDNHN-R 265
            WY G + R +AQ  L+ +  G FLVR S   PG YVLS   +EN    H I+    N R
Sbjct: 13  AWYFGPVLRPEAQNRLQGQKHGMFLVRDSSTCPGDYVLS--VSENSKVSHYIITSLPNKR 70

Query: 266 VRTRDRTFSNISELIDYH 283
            +  DR F ++  L++++
Sbjct: 71  FKIGDREFEHLPALLEFY 88


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 33/94 (35%), Positives = 48/94 (51%), Gaps = 10/94 (10%)

Query: 211 WYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLS----GRTAENEHKHLILLDNH 263
           WYH N++R  A+ LL+    EG F+VR S H  G Y +S     R+ E   KH  +  N 
Sbjct: 150 WYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTISVFMGARSTEAAIKHYQIKKND 208

Query: 264 N-RVRTRDR-TFSNISELIDYHVNNGMAVRSEGR 295
           + +    +R  F +I ELI YH +N   + +  R
Sbjct: 209 SGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLR 242


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2 Tax=Endopterygota
           RepID=UPI0000D57699
          Length = 725

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 40/109 (36%), Positives = 53/109 (48%), Gaps = 25/109 (22%)

Query: 211 WYHGNLSREDAQALLKTE----GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           WYHG LSRE  + LLK E    G FLVR+S+ + G +VLS     NE  H  +     R 
Sbjct: 9   WYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLS-VLHNNEVSHFQI-----RR 62

Query: 267 RTRDRTFS--------NISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
            + D  FS         +  LI+++VN    + SEG      L+L  PV
Sbjct: 63  HSEDAFFSIDENTKIHGLESLIEHYVNT-KGILSEG------LSLTVPV 104


>UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria RepID=Q2VXS8_HUMAN
          Length = 764

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 2/83 (2%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
           P V + +  ++WYHG + R +   LL   GDFLVR+S     +YVLS    +   +H I+
Sbjct: 391 PEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLS-VLWDGLPRHFII 448

Query: 260 LDNHNRVRTRDRTFSNISELIDY 282
               N  R     F +I  LID+
Sbjct: 449 QSLDNLYRLEGEGFPSIPLLIDH 471


>UniRef50_Q14451 Growth factor receptor-bound protein 7 n=89 Tax=Euteleostomi
           RepID=GRB7_HUMAN
          Length = 532

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 38/154 (24%), Positives = 73/154 (47%), Gaps = 31/154 (20%)

Query: 148 KLIDVLTTAINVNTFDAQANASTSNDGFTVPAPP--MRHRSSLHRQSFVSNCRAPTVTED 205
           ++I+    A++V   +AQA    +N   ++P P       +++HR               
Sbjct: 383 RVIENPREALSVALEEAQAWRKKTNHRLSLPMPASGTSLSAAIHRT-------------- 428

Query: 206 VVGKVWYHGNLSREDAQALLKTE----GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
              ++W+HG +SRE++Q L+  +    G FLVR+S   P  +VLS      + KH ++L 
Sbjct: 429 ---QLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLS-LCHLQKVKHYLILP 484

Query: 262 NHNRVRTR------DRTFSNISELIDYH-VNNGM 288
           +    R           F+++ +L+++H +N G+
Sbjct: 485 SEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGI 518


>UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA
          Length = 1315

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 30/82 (36%), Positives = 41/82 (50%), Gaps = 4/82 (4%)

Query: 211  WYHGNLSREDAQALLKTEGDFLVRQSDHT-PGKYVLSGRTAENEHKHLILLDN-HNRVRT 268
            W+HG L RE+   LL+ EGDFLVR++      + VLS     N HKH I+        R 
Sbjct: 951  WFHGVLPREEVVRLLRNEGDFLVRETTRNDESQTVLS--VCWNGHKHFIVQTTAEGHYRF 1008

Query: 269  RDRTFSNISELIDYHVNNGMAV 290
                F +I ELI +   + + V
Sbjct: 1009 EGPAFPSIQELIVHQYQSELPV 1030


>UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_DROER
          Length = 220

 Score = 45.8 bits (107), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 5/98 (5%)

Query: 211 WYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+H  +S  +A+ LL+ +G    FL R S   PG + LS R   NE  H+ + +N +   
Sbjct: 52  WFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRG-NEVTHIKIQNNGDFFD 110

Query: 268 TR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
                 F+ + EL+ Y++ NG      G+  E    LI
Sbjct: 111 LYGGEKFATLPELVQYYMENGELKEKNGQAIELKQPLI 148


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score = 45.4 bits (106), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 12/102 (11%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD----FLVRQSDHTPGKYVLSGRTA 250
           SN  AP   + +  + WY G + R+DA+ LL   G+    FLVR+S+ T G Y LS R  
Sbjct: 144 SNYVAPA--DSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDW 201

Query: 251 EN------EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNN 286
           +       +H  +  LDN     T    F  + +L+ ++  +
Sbjct: 202 DEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEH 243


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score = 45.4 bits (106), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 34/127 (26%), Positives = 61/127 (48%), Gaps = 27/127 (21%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE----GDFLVRQSDHTPGKYVLSGRTAE 251
           N  AP  + +V G  W+ G+ +R +A   L+ +    G FLVR+S+  PG Y L+ R  E
Sbjct: 100 NYVAPVNSLEVEG--WFFGSCTRSEAIMRLQADNLPKGTFLVRESETRPGTYALTVR--E 155

Query: 252 NEHKHLILLDNHNRVRTRD----------RTFSNISELIDYHVNNGMAVRSEGRDRETSL 301
            +H H   + N+   +T+D          R F+ + +++ +H +    + S+        
Sbjct: 156 TDHGHPPTIKNYRVDKTKDGSELFFINPQRKFNTVIDVVKFHTSQPGGLCSK-------- 207

Query: 302 NLIRPVP 308
            L++P P
Sbjct: 208 -LLKPCP 213


>UniRef50_A7SCW1 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SCW1_NEMVE
          Length = 275

 Score = 45.4 bits (106), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 31/109 (28%), Positives = 52/109 (47%), Gaps = 6/109 (5%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WYHG L R + + +L  K  G +LVR S   PG YVLS  +   +  H I+ +       
Sbjct: 9   WYHGVLKRVETEGILNGKPPGVWLVRDSTTIPGDYVLS-VSESGKVSHYIINNKGTMYTI 67

Query: 269 RDRTFSNISELIDY---HVNNGMAVRSEGRDRETSLNLIRPVPCPGSDD 314
            D+TF ++  +I++   H  +   ++    + E ++ +      PG DD
Sbjct: 68  GDQTFPDLPSIIEFYKKHFLDTTTLKEHVPNSECNIKVKALYAFPGKDD 116


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score = 45.4 bits (106), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 25/102 (24%), Positives = 52/102 (50%), Gaps = 3/102 (2%)

Query: 211 WYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           WY G +SR+ A+ +L      G FL+R+S+ +PG++ +S    +      +L +   +  
Sbjct: 60  WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYF 119

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             +  F++++EL+D++    +A + +   R+    L  P  C
Sbjct: 120 LWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGAC 161


>UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related adapter protein 2 n=5
           Tax=Homo sapiens RepID=B7Z8F8_HUMAN
          Length = 304

 Score = 45.4 bits (106), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 25/87 (28%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 209 KVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           K W+H  LSR  A+ LL  K  G F++R S  +PG + +S R  ++     ++ DN    
Sbjct: 30  KRWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNY 89

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSE 293
                 F ++++L+DY+  N ++ + +
Sbjct: 90  FLWTEKFPSLNKLVDYYRTNSISRQKQ 116


>UniRef50_A9USN6 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9USN6_MONBE
          Length = 954

 Score = 45.4 bits (106), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 26/79 (32%), Positives = 45/79 (56%), Gaps = 4/79 (5%)

Query: 209 KVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRT-AENEHKHLILLDNHNR 265
           ++W   ++SR+DA+  LK   +G +L+R S   PG YVL      + +H  + +  N+ R
Sbjct: 8   QIWLSRHISRQDAETALKGHPDGTYLIRASVSAPGDYVLCVVCHGQIQHHQVCIKHNNGR 67

Query: 266 VRTRD-RTFSNISELIDYH 283
           + TR  R   N+SEL+ ++
Sbjct: 68  MLTRSGRELQNLSELLRHY 86


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score = 45.4 bits (106), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 35/122 (28%), Positives = 58/122 (47%), Gaps = 16/122 (13%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGD----FLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
           E V  + W+ G +SR +A   L+ EG+    FL+R S+     YVLS R  +    + I 
Sbjct: 71  ETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIW 130

Query: 260 LDNHNRVRTRDR-TFSNISELIDYH----VNNGMAVRSEGRDRETSLNLIRPVPCPGSDD 314
                R+   +  +F ++ EL++YH    +++G+ + +  R  E       P P P  DD
Sbjct: 131 RRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHE-------PEPLPHWDD 183

Query: 315 IE 316
            E
Sbjct: 184 WE 185


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score = 45.4 bits (106), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 22/76 (28%), Positives = 41/76 (53%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+ G + R  A+ +L   + +G FL+R+S+  PG + LS +   +     +L D   +  
Sbjct: 60  WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYF 119

Query: 268 TRDRTFSNISELIDYH 283
                F++++EL+DYH
Sbjct: 120 LWVVKFNSLNELVDYH 135


>UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000586DB6
          Length = 177

 Score = 45.4 bits (106), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 23/70 (32%), Positives = 42/70 (60%), Gaps = 2/70 (2%)

Query: 216 LSREDAQALLKTEGD--FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTF 273
           ++R+ A+ LLK +GD  FL+R+S+ TPG Y LS +  +      +L D   +       F
Sbjct: 28  VTRDGAEELLKNDGDGAFLIRESEGTPGDYSLSVKFVDGVQHFKVLRDGAGKYFLWVVKF 87

Query: 274 SNISELIDYH 283
           +++++L++YH
Sbjct: 88  NSLNQLVEYH 97


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score = 45.1 bits (105), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 8/108 (7%)

Query: 206 VVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +V K WY+G+++R     LL     +GDFL+R S+   G Y +S + A   +KH  +   
Sbjct: 307 LVDKPWYYGSITRYMCDNLLNQRGHDGDFLIRDSETNVGDYSVSLK-APGRNKHFRVHVE 365

Query: 263 HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
                   R F  + +L+D++    +    +G      L L+RP+P P
Sbjct: 366 GALYCIGQRKFHTLDQLVDHYQRAPIYTNKQGE----KLYLVRPLPKP 409


>UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clupeocephala
           RepID=UPI0001A2CA18
          Length = 257

 Score = 45.1 bits (105), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 18/96 (18%)

Query: 211 WYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           W++ NLSR DA   L     T+G FL+R+S+  PG + +S R  +     +I    H R+
Sbjct: 120 WFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVRDLDPMQGDII---KHYRI 176

Query: 267 RTRDR---------TFSNISELIDYHVN--NGMAVR 291
           R  D          +F+++SEL+ ++    +G+  R
Sbjct: 177 RNMDAGGFYITNKISFNSLSELVKHYSREADGLCTR 212


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score = 45.1 bits (105), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 25/91 (27%), Positives = 47/91 (51%), Gaps = 2/91 (2%)

Query: 205 DVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           D+    W+H  LSR  A+ LL  K  G F++R S  +PG + +S R  ++     ++ DN
Sbjct: 52  DIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDN 111

Query: 263 HNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
                     F ++++L+DY+  N ++ + +
Sbjct: 112 KGNYFLWTEKFPSLNKLVDYYRTNSISRQKQ 142


>UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y2_9METZ
          Length = 743

 Score = 45.1 bits (105), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 32/109 (29%), Positives = 52/109 (47%), Gaps = 12/109 (11%)

Query: 211 WYHGNLSREDAQALL------KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
           WYHG ++RE+A  L+      + EG FLVR+S  TPG YVL+     N  +  I+     
Sbjct: 10  WYHGKITRENAAHLVSQGPITRREGLFLVRESTRTPGSYVLTLWAKGNVQQFQIMGHGEG 69

Query: 265 RVRTRD-RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGS 312
                +   F  + ELI ++      ++ +G   + +  +I   P PG+
Sbjct: 70  WFSVDNGPLFQGLDELIHHY-----QLKPDGLPVQLNDYVIGNPPPPGA 113


>UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=SH2B1_HUMAN
          Length = 756

 Score = 45.1 bits (105), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 31/97 (31%), Positives = 52/97 (53%), Gaps = 7/97 (7%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGD-----FLVRQSDHTPGKYVLSGRTAENEHKHLI 258
           + + G  W+HG LSR  A  L+ T G      FLVRQS+   G+YVL+    + + KHL 
Sbjct: 520 QPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLT-FNFQGKAKHLR 578

Query: 259 L-LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
           L L+   + R +   F +I +++++   + + + S G
Sbjct: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGG 615


>UniRef50_Q54U31 Dual specificity protein kinase shkD n=1 Tax=Dictyostelium
           discoideum RepID=SHKD_DICDI
          Length = 744

 Score = 44.7 bits (104), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 22/80 (27%), Positives = 44/80 (55%), Gaps = 6/80 (7%)

Query: 208 GKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN- 264
            K+W+HG++ RE A + L    EG FL+R S   P     +     N+H+ + L+D +N 
Sbjct: 638 AKIWFHGDIVREQATSRLSKAAEGAFLIRLSSTEPKTCPFTLSMKNNQHRRIQLIDENNF 697

Query: 265 ---RVRTRDRTFSNISELID 281
              +++ +   ++++ EL++
Sbjct: 698 TGFKIQGKTAVYNSLIELVE 717


>UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6 n=11 Tax=Eumetazoa
           RepID=C0H9A3_SALSA
          Length = 582

 Score = 44.7 bits (104), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 31/105 (29%), Positives = 50/105 (47%), Gaps = 18/105 (17%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLSGRTAEN 252
           NC  PT         WYHG+LS  +A+ LL      G FLVR+S   PG +VLS  T E 
Sbjct: 101 NCSDPTTER------WYHGHLSGPNAEKLLWERDEPGTFLVRESLSKPGDFVLSVLTEEK 154

Query: 253 EH--------KHLILLDNHNRVRTRDR-TFSNISELIDYHVNNGM 288
                      H+ ++  ++R     +  F  +++L++++   G+
Sbjct: 155 SKASSGGRRVSHIKIMCQNDRYTVGGKEMFDTLADLMEHYKRKGI 199


>UniRef50_A9V2L8 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V2L8_MONBE
          Length = 877

 Score = 44.7 bits (104), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 22/40 (55%), Positives = 27/40 (67%), Gaps = 4/40 (10%)

Query: 211 WYHGNLSREDAQALLKTEGD----FLVRQSDHTPGKYVLS 246
           W HG +SRE A+ALLK +G     FLVR+S   PG +VLS
Sbjct: 302 WLHGEISREVAEALLKQQGAADGLFLVRRSTSVPGAFVLS 341


>UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia malayi
           RepID=A8Q5B5_BRUMA
          Length = 1138

 Score = 44.7 bits (104), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 38/107 (35%), Positives = 56/107 (52%), Gaps = 12/107 (11%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTP-GKYVLSGRTAENEHKHLILL---DNHNR- 265
           WYHG LSRED + LL   GDFLVR +D+    + VLS    E  + HL +    D H + 
Sbjct: 723 WYHGLLSREDIEKLLVKNGDFLVRVTDNQGVHQIVLSIHVGE-RNIHLTIAVTEDGHFQL 781

Query: 266 -VRTRDRTFSNISELIDYHVNNGMAVR-SEGRDRETSLNLIRPVPCP 310
            V  R   F +I +L+ Y+  + + ++ + G+D    + L   VP P
Sbjct: 782 SVLRRGPRFPSIYDLVQYYKMHKIKIKDASGKD----IRLGDGVPKP 824


>UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicini RepID=B0WDQ7_CULQU
          Length = 1081

 Score = 44.7 bits (104), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 29/86 (33%), Positives = 45/86 (52%), Gaps = 5/86 (5%)

Query: 211  WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR--- 265
            WYHG++SR DA+ +L+   EG FLVR S+ T   Y L+ ++A+      I  D  +    
Sbjct: 980  WYHGSISRIDAEKILRPLGEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDPDSSQYI 1039

Query: 266  VRTRDRTFSNISELIDYHVNNGMAVR 291
            +    R F  I ++I +   N + VR
Sbjct: 1040 LGQFSRPFPTIPDMIRHFCLNRLPVR 1065


>UniRef50_P00528 Tyrosine-protein kinase Src64B n=19 Tax=Neoptera RepID=SRC64_DROME
          Length = 552

 Score = 44.7 bits (104), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 28/90 (31%), Positives = 43/90 (47%), Gaps = 10/90 (11%)

Query: 211 WYHGNLSREDAQALLKTE----GDFLVRQSDHTPGKYVLS------GRTAENEHKHLILL 260
           W+  N+ R++A  LL  E    G FLVR S+H P  Y LS      GR    +H  +  L
Sbjct: 162 WFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPL 221

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           DN       ++TF ++  L+  +  N + +
Sbjct: 222 DNGGYYIATNQTFPSLQALVMAYSKNALGL 251


>UniRef50_UPI000180BE98 PREDICTED: similar to inositol polyphosphate phosphatase-like 1 n=1
           Tax=Ciona intestinalis RepID=UPI000180BE98
          Length = 1239

 Score = 44.7 bits (104), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 27/91 (29%), Positives = 48/91 (52%), Gaps = 11/91 (12%)

Query: 209 KVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
           ++WYHG ++R+ ++ LL     +G F+VR S+   G Y LS     + H + IL   +N 
Sbjct: 4   EIWYHGRVNRQQSEELLLSAAVDGSFVVRASESRAGAYALSVLFNNSVHTYRILPTENNT 63

Query: 266 VR------TRDRTFSNISELIDYHVN--NGM 288
           +        + R F +++EL+  + N  NG+
Sbjct: 64  LAVQTVNGVQQRKFKSLTELVHEYRNSQNGL 94


>UniRef50_O14492 SH2B adapter protein 2 n=4 Tax=Catarrhini RepID=SH2B2_HUMAN
          Length = 632

 Score = 44.7 bits (104), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 27/90 (30%), Positives = 49/90 (54%), Gaps = 7/90 (7%)

Query: 211 WYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHN 264
           W+HG LSR  A  L+     +  G F++RQS+  PG+YVL+    + + KHL L L+ H 
Sbjct: 417 WFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTF-NFQGKAKHLRLSLNGHG 475

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
           +   +   F ++ +++ +   + + + S G
Sbjct: 476 QCHVQHLWFQSVLDMLRHFHTHPIPLESGG 505


>UniRef50_A8PJL3 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8PJL3_BRUMA
          Length = 668

 Score = 44.7 bits (104), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 29/91 (31%), Positives = 50/91 (54%), Gaps = 12/91 (13%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAENEHKHLILLDNHNRVR 267
           ++HG L REDA  L   +GDFL+R ++   G   K  LS   A +   H+IL  ++++++
Sbjct: 243 YFHGFLPREDANMLCILDGDFLLRTTEVFSGEDRKLCLS--VAWHGKHHIIL--HYDKLK 298

Query: 268 TR-----DRTFSNISELIDYHVNNGMAVRSE 293
            R      RTF  I++L++Y+  +   +  E
Sbjct: 299 NRYGIKPSRTFPTITDLVNYYAQHRFKILKE 329


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score = 44.7 bits (104), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 25/149 (16%)

Query: 177 VPAPPMRHRSSL-------------HRQSFVSNCRAPTVTEDVVG---KVWYHGNLSRED 220
           +P PP  H ++L             H  S   +C     +   VG   + WYHG + R  
Sbjct: 117 IPVPPNDHSTTLNTGSASGSSLTFQHTSSHDVSCNGSQGSLARVGLESEKWYHGAIQRSY 176

Query: 221 AQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT-RDRTFSNIS 277
           A+ LL +   G FL+R+S+  PG+  +S R       + I  D+ N         F+++S
Sbjct: 177 AEYLLNSGITGSFLIRESESHPGQLTISLRYEGQIWHYRIHRDDSNMYYVIESNKFTSVS 236

Query: 278 ELIDYHV--NNGMAVR----SEGRDRETS 300
           +L+ +H   ++G+A      +  RDR +S
Sbjct: 237 DLVHHHEKHSDGLACTLLYPAPKRDRTSS 265


>UniRef50_B1NJG1 Suppressor of cytokine signaling 2 (Fragment) n=2 Tax=Euteleostomi
           RepID=B1NJG1_ORYLA
          Length = 157

 Score = 44.3 bits (103), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 28/83 (33%), Positives = 45/83 (54%), Gaps = 9/83 (10%)

Query: 211 WYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAEN------EHKH-LILLD 261
           WY GNL+  +A+A+L+   EG FL+R S      + +S  T+        E+KH    LD
Sbjct: 1   WYWGNLTANEAKAILQDSPEGTFLLRDSSQRDYLFTISAMTSAGPTNLRIEYKHGKFKLD 60

Query: 262 NHNRVRTRDRTFSNISELIDYHV 284
           +   V+ + R F ++  L+DY+V
Sbjct: 61  SVVLVKPKLRQFDSVVHLVDYYV 83


>UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homology 2 domain
           containing transforming protein D (SHD) n=1 Tax=Danio
           rerio RepID=A8WHR4_DANRE
          Length = 321

 Score = 44.3 bits (103), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 36/154 (23%), Positives = 70/154 (45%), Gaps = 11/154 (7%)

Query: 145 DVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTE 204
           +  + I+V   A + +      + +    G +  +PP    +SL +   +   R   +  
Sbjct: 156 EAQRFINVTFEAADWDQCTLPCDEALRKAGVSRVSPPSSGATSLRKPHGILGERVDPMLP 215

Query: 205 DVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
            +  +VWYHG L+R +A++LL    E  +LVR+S  +   Y LS R+    H  + +  +
Sbjct: 216 -LEKQVWYHGALTRSEAESLLTLCKECSYLVRKSQTSRNDYSLSLRSC---HGFMHMKFS 271

Query: 263 HNR-----VRTRDRTFSNISELIDYHVNNGMAVR 291
            +R     +      F +I E+I ++  N + +R
Sbjct: 272 QSRDGKFILGENSPPFDSIPEVIHFYTTNKLPIR 305


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score = 44.3 bits (103), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 36/137 (26%), Positives = 67/137 (48%), Gaps = 14/137 (10%)

Query: 150 IDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGK 209
           I+ +T    VN   A ++ ST+       +P     ++L  Q   S C        +   
Sbjct: 428 INGVTAGSGVNASSAWSSGSTTAMNHASLSP-----TALAPQQGRSRCEV-----KLNAM 477

Query: 210 VWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLS-GRTAENEHKHLILLDNHNRV 266
            W+HG+++R++A+ LL  + +G FLVR+S + PG Y L     ++ EH  +  L+N   +
Sbjct: 478 PWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTI 537

Query: 267 RTRDRTFSNISELIDYH 283
              +  F N+ +L+ ++
Sbjct: 538 -DDEEYFENLGQLVAHY 553


>UniRef50_Q5SQS7 SH2 domain-containing protein 4B n=28 Tax=Euteleostomi
           RepID=SH24B_HUMAN
          Length = 431

 Score = 44.3 bits (103), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 31/85 (36%), Positives = 49/85 (57%), Gaps = 7/85 (8%)

Query: 211 WYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL---LDNHNR 265
           W+HG +SREDA+ALL+  TEG FLVR S+   G Y LS R  +   KH ++    D ++ 
Sbjct: 325 WFHGIISREDAEALLENMTEGAFLVRVSEKIWG-YTLSYRLQKG-FKHFLVDASGDFYSF 382

Query: 266 VRTRDRTFSNISELIDYHVNNGMAV 290
           +       + +++L+D+H    + V
Sbjct: 383 LGVDPNRHATLTDLVDFHKEEIITV 407


>UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateria RepID=FPS_DROME
          Length = 1325

 Score = 44.3 bits (103), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 32/86 (37%), Positives = 44/86 (51%), Gaps = 6/86 (6%)

Query: 211  WYHGNLSREDAQALLKTEGDFLVRQS-DHTPGKYVLSGRTAENEHKHLIL-LDNHNRVRT 268
            W+HG L RE+   LL  +GDFLVR++  +   + VLS     N HKH I+        R 
Sbjct: 960  WFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLS--VCWNGHKHFIVQTTGEGNFRF 1017

Query: 269  RDRTFSNISELI--DYHVNNGMAVRS 292
                F++I ELI   YH    + V+S
Sbjct: 1018 EGPPFASIQELIMHQYHSELPVTVKS 1043


>UniRef50_Q18865 Putative uncharacterized protein n=6 Tax=Caenorhabditis
           RepID=Q18865_CAEEL
          Length = 431

 Score = 44.3 bits (103), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 4/87 (4%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAEN-EHKHLIL 259
           +D++ + +YHG L RED Q +L   G FL+R S+   G   ++VLS    +N    H ++
Sbjct: 4   KDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKNTSANHFVV 63

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNN 286
            +  ++V      F  I EL++++V+ 
Sbjct: 64  READHKVYVDKIGFPTIIELVNHYVST 90


>UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7PSP3_IXOSC
          Length = 674

 Score = 44.3 bits (103), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 28/84 (33%), Positives = 42/84 (50%), Gaps = 2/84 (2%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN-RVRTR 269
           W+HG L RE+   LL   GD+LVR++     K V+     +  HKH I+    + + R  
Sbjct: 313 WFHGVLPREEVVRLLVNNGDYLVRETMRNEEKQVVLSVCWQG-HKHFIVQTTSDGKYRFE 371

Query: 270 DRTFSNISELIDYHVNNGMAVRSE 293
              F  + ELI Y  + G+ V S+
Sbjct: 372 GPAFGTVQELIVYQHHLGLPVTSK 395


>UniRef50_B7Q2R0 Adaptor protein Crk, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7Q2R0_IXOSC
          Length = 310

 Score = 44.3 bits (103), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 28/80 (35%), Positives = 41/80 (51%), Gaps = 8/80 (10%)

Query: 211 WYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLSGRTAENEHKHLIL----LDNH 263
           W+ G +SR++A  +L  E   G FLVR S    G  VL  R  EN+  H I+     D  
Sbjct: 13  WFFGPMSRQEATDMLMAEHEAGIFLVRNSATISGDLVLCVR-EENKVSHYIINRVSQDEQ 71

Query: 264 NRVRTRDRTFSNISELIDYH 283
            R R  D+ F +I  L++++
Sbjct: 72  TRFRIGDQMFPDIPSLLNFY 91


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score = 44.3 bits (103), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 26/83 (31%), Positives = 48/83 (57%), Gaps = 5/83 (6%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I   +  ++  
Sbjct: 13  WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 72

Query: 268 TRDRTFSNISELIDYH--VNNGM 288
           + +  F+ ++EL+ +H  V +G+
Sbjct: 73  SSESRFNTLAELVHHHSTVADGL 95


>UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X6G9_CULQU
          Length = 109

 Score = 44.3 bits (103), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 30/103 (29%), Positives = 52/103 (50%), Gaps = 8/103 (7%)

Query: 211 WYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+H ++S  DA+ LL     +G FL R S   PG + LS R  + E  H+ + +N +   
Sbjct: 4   WFHPSVSGVDAEKLLLERGFDGSFLARLSSSNPGAFTLSVRRGK-EVTHIKIQNNGDFFD 62

Query: 268 TR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                 F+ +SEL+ Y++ NG  ++ +       + L +P+ C
Sbjct: 63  LYGGEKFATLSELVQYYMENGGQLKEKNGQ---IIELKQPLIC 102


>UniRef50_B3MIV6 GF12762 n=3 Tax=Drosophila RepID=B3MIV6_DROAN
          Length = 940

 Score = 44.3 bits (103), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 22/39 (56%), Positives = 26/39 (66%), Gaps = 3/39 (7%)

Query: 211 WYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLS 246
           W+HGNLSRE A  LLK    +G FLVR+S    G +VLS
Sbjct: 10  WFHGNLSREAADDLLKQGYEDGTFLVRESSTAAGDFVLS 48


>UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Gallus gallus RepID=UPI0000ECA6D9
          Length = 506

 Score = 44.3 bits (103), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 30/90 (33%), Positives = 47/90 (52%), Gaps = 7/90 (7%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQAL-----LKTEGDFLVRQSDHTPGKYVLSGRTAENE 253
            P + + +    W+HG +SR  A  L     L+  G FLVRQS+   G+YVL+    +  
Sbjct: 376 GPKMEQFLSSCPWFHGPISRVKAAQLVQLGGLEGHGVFLVRQSETRRGEYVLT-FNFQGR 434

Query: 254 HKHLIL-LDNHNRVRTRDRTFSNISELIDY 282
            KHL L L    + R +   FS+I+E++ +
Sbjct: 435 AKHLRLSLTERGQCRVQHLRFSSITEMLHH 464


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score = 44.3 bits (103), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 28/78 (35%), Positives = 44/78 (56%), Gaps = 6/78 (7%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN---R 265
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I  D  +    
Sbjct: 174 WYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDTSDGKVY 233

Query: 266 VRTRDRTFSNISELIDYH 283
           V T  R F+ ++EL+ +H
Sbjct: 234 VTTESR-FNTLAELVHHH 250


>UniRef50_UPI00005A0859 PREDICTED: similar to SH2 domain containing 4B n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A0859
          Length = 488

 Score = 44.3 bits (103), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 30/78 (38%), Positives = 46/78 (58%), Gaps = 7/78 (8%)

Query: 211 WYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL---LDNHNR 265
           W+HG +SREDA+ LL+  TEG FLVR S+   G Y LS R  +   KH ++    D ++ 
Sbjct: 382 WFHGIISREDAEDLLENMTEGAFLVRVSEKIWG-YTLSYRLQKG-FKHFLVDASGDFYSF 439

Query: 266 VRTRDRTFSNISELIDYH 283
           +       + +++LID+H
Sbjct: 440 LGVDPNRHATLTDLIDFH 457


>UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein kinase Lyn n=2
           Tax=Euteleostomi RepID=UPI00017F07B9
          Length = 580

 Score = 43.9 bits (102), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 28/91 (30%), Positives = 46/91 (50%), Gaps = 16/91 (17%)

Query: 211 WYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           W+  +++R+DA+  L     + G FL+R+S+   G Y LS R  +  H  +I    H ++
Sbjct: 177 WFFKDITRKDAERQLLAPGNSPGAFLIRESETLKGSYSLSVRDYDPVHGDVI---KHYKI 233

Query: 267 RTRDR---------TFSNISELIDYHVNNGM 288
           R+ D          TF  IS++I Y+  N M
Sbjct: 234 RSLDNGGYYISPRITFPCISDMIKYYQTNYM 264


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score = 43.9 bits (102), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 36/137 (26%), Positives = 67/137 (48%), Gaps = 14/137 (10%)

Query: 150 IDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGK 209
           I+ +T    VN   A ++ ST+       +P     ++L  Q   S C        +   
Sbjct: 633 INGVTAGSGVNASSAWSSGSTTAMNHASLSP-----TALAPQQGRSRCEV-----KLNAM 682

Query: 210 VWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLS-GRTAENEHKHLILLDNHNRV 266
            W+HG+++R++A+ LL  + +G FLVR+S + PG Y L     ++ EH  +  L+N   +
Sbjct: 683 PWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKLTI 742

Query: 267 RTRDRTFSNISELIDYH 283
              +  F N+ +L+ ++
Sbjct: 743 -DDEEYFENLGQLVAHY 758


>UniRef50_UPI0000E4816C PREDICTED: similar to phosphoinositide-3-kinase n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E4816C
          Length = 820

 Score = 43.9 bits (102), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 12/117 (10%)

Query: 138 CHVVFIEDVHKLIDVLTTAIN----VNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSF 193
           CH++     H+LI+V+    +    VNT         +++    P PP R     +  + 
Sbjct: 431 CHILLRPPQHELINVIRNTNDHKEIVNTLIEHGRWGNTSEE-DAPEPPPRKSPGDYISTG 489

Query: 194 VSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGR 248
            ++   P    D     WY G++SRE+    LK   +G FLVR S   PG Y L+ R
Sbjct: 490 STD--YPKSLNDAE---WYWGSISREEVNEKLKDMPDGTFLVRDSKQEPGNYTLTLR 541


>UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicum
           RepID=Q5DBN4_SCHJA
          Length = 312

 Score = 43.9 bits (102), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 11/84 (13%)

Query: 211 WYHGNLSREDAQA-LLKTE----------GDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
           WY    SR +A+A LL+T+          G F++RQS++ PG + +S +   +     I 
Sbjct: 60  WYIPKCSRREAEARLLETDPNTHRDVQPDGAFVLRQSENDPGHFSISVKEGSSVLHFRIF 119

Query: 260 LDNHNRVRTRDRTFSNISELIDYH 283
            D   +       FS+I+ LIDYH
Sbjct: 120 FDPSGKYYIWTNKFSSINALIDYH 143


>UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax=Euteleostomi
           RepID=SHF_MOUSE
          Length = 238

 Score = 43.9 bits (102), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 25/87 (28%), Positives = 49/87 (56%), Gaps = 4/87 (4%)

Query: 209 KVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAEN-EHKHLILLDNHNR 265
           +VWYHG +SR DA+ LL+   E  +LVR S+ +   + LS ++++   H  L     H  
Sbjct: 136 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 195

Query: 266 VRTRDR-TFSNISELIDYHVNNGMAVR 291
           V  ++   FS++ E++ ++ +  + ++
Sbjct: 196 VLGQNSPPFSSVPEIVHHYASRKLPIK 222


>UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambiae
           RepID=Q7QGU0_ANOGA
          Length = 837

 Score = 43.9 bits (102), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 5/86 (5%)

Query: 211 WYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR--- 265
           WYHG++SR DA+ +L+  +EG FLVR S+ T   Y L+ ++A+      I  D  +    
Sbjct: 736 WYHGSISRIDAEKILRPLSEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDADSGQFI 795

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVR 291
           +    R F  I ++I +   N + VR
Sbjct: 796 LGQFSRPFPTIPDMIRHFCLNRLPVR 821


>UniRef50_O01798 Defective spermatogenesis protein 8 n=3 Tax=Caenorhabditis
           RepID=O01798_CAEEL
          Length = 512

 Score = 43.9 bits (102), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 29/97 (29%), Positives = 50/97 (51%), Gaps = 14/97 (14%)

Query: 202 VTEDVVGKV--------WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENE 253
           V  D VG+V        +YHG + R + +A+L   GDFL+R ++   GK V    + + +
Sbjct: 97  VPSDEVGRVENNIDNFPFYHGFMGRNECEAMLSNHGDFLIRMTE--IGKRVAYVISIKWK 154

Query: 254 HKHLILLDNHNRVR----TRDRTFSNISELIDYHVNN 286
           ++++ +L    + +    T+   F +I ELI YH  N
Sbjct: 155 YQNIHVLVKRTKTKKLYWTKKYAFKSICELIAYHKRN 191


>UniRef50_C4QQ21 Expressed protein n=1 Tax=Schistosoma mansoni RepID=C4QQ21_SCHMA
          Length = 1124

 Score = 43.9 bits (102), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 26/77 (33%), Positives = 44/77 (57%), Gaps = 4/77 (5%)

Query: 172  NDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EG 229
            N+   +PA   RH+ S   +   S+  A  ++E +  ++W+H +LSR  A+ LLK+   G
Sbjct: 984  NENLHIPAEYYRHQKSDFSRHHSSSTTA--ISEQLENQLWFHRDLSRSHAEKLLKSTPTG 1041

Query: 230  DFLVRQSDHTPGKYVLS 246
             FLVR+S+ +  +  LS
Sbjct: 1042 SFLVRRSETSKTELSLS 1058


>UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7T185_NEMVE
          Length = 983

 Score = 43.9 bits (102), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 29/92 (31%), Positives = 49/92 (53%), Gaps = 4/92 (4%)

Query: 208 GKVWYHGNLSREDAQ--ALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL-ILLDNHN 264
           G   + G + R +A+   + +++G FLVR+S +  G+Y LS R   N  KH+ I  ++  
Sbjct: 657 GTTGFAGKMDRTEAEQETMGRSDGTFLVRESANRAGEYALSVR-FRNATKHIKIPYEDGT 715

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEGRD 296
              T+ + F +I EL+ Y+  N + V   G D
Sbjct: 716 FCLTQSKVFDSIPELVAYYRENTLGVSFTGLD 747


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score = 43.9 bits (102), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 24/76 (31%), Positives = 44/76 (57%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I   +  ++  
Sbjct: 127 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 186

Query: 268 TRDRTFSNISELIDYH 283
           + +  F+ ++EL+ +H
Sbjct: 187 SSESRFNTLAELVHHH 202


>UniRef50_B5DYC5 GA27425 n=4 Tax=Drosophila RepID=B5DYC5_DROPS
          Length = 727

 Score = 43.9 bits (102), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 32/95 (33%), Positives = 45/95 (47%), Gaps = 12/95 (12%)

Query: 208 GKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEH------KHLIL 259
            K WY  NLSREDA ALL +   G FLVR S      Y L  R A+         +H ++
Sbjct: 463 AKFWYKANLSREDAIALLASAQPGTFLVRDSTTYKNAYGLVVRVAQPPAGSQELVRHFLI 522

Query: 260 LDNHNRVRTR----DRTFSNISELIDYHVNNGMAV 290
                 VR +    +  F+++S L+  H  N +A+
Sbjct: 523 EPTREGVRLKGCDNEPVFTSLSALVFEHSINRLAL 557


>UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=9 Tax=Euteleostomi
           RepID=A2AQ87_MOUSE
          Length = 446

 Score = 43.9 bits (102), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 25/87 (28%), Positives = 49/87 (56%), Gaps = 4/87 (4%)

Query: 209 KVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAEN-EHKHLILLDNHNR 265
           +VWYHG +SR DA+ LL+   E  +LVR S+ +   + LS ++++   H  L     H  
Sbjct: 344 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKY 403

Query: 266 VRTRDR-TFSNISELIDYHVNNGMAVR 291
           V  ++   FS++ E++ ++ +  + ++
Sbjct: 404 VLGQNSPPFSSVPEIVHHYASRKLPIK 430


>UniRef50_UPI0001925DBE PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI0001925DBE
          Length = 249

 Score = 43.9 bits (102), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 35/107 (32%), Positives = 52/107 (48%), Gaps = 6/107 (5%)

Query: 211 WYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN-HNRV 266
           W+HG+++R  ++ALL     EG +LVR S   PG Y +S R  ++  KH  L  N H+  
Sbjct: 54  WFHGDMTRNTSEALLLANGVEGTYLVRNSASDPGSYTVSVR-CQSSIKHYSLRHNVHDNT 112

Query: 267 RTRDRTFSN-ISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGS 312
            T  R F +  ++LID+     +     G         I+ VP P S
Sbjct: 113 YTFGRGFYDSYNDLIDHFECKPVLTGETGEPVIFRYPYIKDVPEPSS 159


>UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor receptor-bound protein 2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A1C
          Length = 176

 Score = 43.5 bits (101), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 26/87 (29%), Positives = 43/87 (49%), Gaps = 2/87 (2%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKH 256
            P  T   +   W+   ++R++A+ LL  E  G FLVR+S+ + G Y LS +  E+    
Sbjct: 2   GPKHTYPEIAMAWFFPTITRKNAELLLMQERNGAFLVRRSESSEGLYSLSVKYNESVQHF 61

Query: 257 LILLDNHNRVRTRDRTFSNISELIDYH 283
            IL D   +       F ++  L+DY+
Sbjct: 62  RILQDTAGKFHLWIVKFPSLDALVDYY 88


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score = 43.5 bits (101), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 30/99 (30%), Positives = 48/99 (48%), Gaps = 12/99 (12%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT----EGDFLVRQSDHTPGKYVLSGRTA 250
           SN  AP   + +  + WY G L R+DA+  L +     G FL+R+S+ T G Y LS R  
Sbjct: 135 SNYVAPV--DSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDW 192

Query: 251 EN------EHKHLILLDNHNRVRTRDRTFSNISELIDYH 283
           ++      +H  +  LDN     T    F  + +L+ ++
Sbjct: 193 DDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY 231


>UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax=Amniota
           RepID=SHF_HUMAN
          Length = 480

 Score = 43.5 bits (101), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 25/87 (28%), Positives = 50/87 (57%), Gaps = 4/87 (4%)

Query: 209 KVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAEN-EHKHLILLDNHNR 265
           +VWYHG +SR DA+ LL+   E  +LVR S+ +   + LS ++++   H  L    N+  
Sbjct: 378 QVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKNNKY 437

Query: 266 VRTRDR-TFSNISELIDYHVNNGMAVR 291
           V  ++   FS++ E++ ++ +  + ++
Sbjct: 438 VLGQNSPPFSSVPEIVHHYASRKLPIK 464


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score = 43.5 bits (101), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 37/143 (25%), Positives = 64/143 (44%), Gaps = 28/143 (19%)

Query: 149 LIDVLTTAINVNTFDAQANASTSNDGFT--VPAPPMRHRSSLHRQSFVSNCRAPTVTEDV 206
           +I++L +  + N +    NA   +DG T  +P   ++ R +LH                 
Sbjct: 48  IIEILQSTRDPNWY----NAKKVSDGRTGLIPINYVQQRRALHLHEMP------------ 91

Query: 207 VGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAEN----EHKHLILL 260
               W+ G ++RE A+ LL  +  G FLVR+S + PG Y L   + +N    EH  +I  
Sbjct: 92  ----WFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVIST 147

Query: 261 DNHNRVRTRDRTFSNISELIDYH 283
            ++      +  F  + ELI ++
Sbjct: 148 SDNQVTVDEEAFFPTLIELIKHY 170


>UniRef50_UPI0000F2C764 PREDICTED: similar to SH2-containing protein Nsp1 n=1
           Tax=Monodelphis domestica RepID=UPI0000F2C764
          Length = 741

 Score = 43.5 bits (101), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 18/36 (50%), Positives = 27/36 (75%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHT 239
           +++V + WYHG LS+++A+ALL  +GDFLV  S  T
Sbjct: 71  KELVDQTWYHGRLSQKEAEALLLKDGDFLVWASPST 106


>UniRef50_A9V6N4 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V6N4_MONBE
          Length = 1698

 Score = 43.5 bits (101), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 32/88 (36%), Positives = 52/88 (59%), Gaps = 11/88 (12%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL 257
           P  T+D     W+H N+SRE+A+  L  + +G FLVR+S  T   +V+S   AENE  H 
Sbjct: 828 PLQTDD-----WFHPNMSREEAETRLDGQPDGVFLVRRST-TTNAHVIS-YAAENETHHA 880

Query: 258 IL--LDNHNRVRTRDRTFSNISELIDYH 283
           ++  +++   VR  +  F+++  LI+YH
Sbjct: 881 LVDTIEDGFVVRDSNTVFASLDVLINYH 908


>UniRef50_UPI00016E9A01 UPI00016E9A01 related cluster n=3 Tax=Tetraodontidae
           RepID=UPI00016E9A01
          Length = 580

 Score = 43.5 bits (101), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 44/160 (27%), Positives = 71/160 (44%), Gaps = 22/160 (13%)

Query: 140 VVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRA 199
           ++F  D  + +   TT I     +   N S   D   +P+PP     S  R S   + + 
Sbjct: 288 LIFETDNDQQVSSWTTEIK----ECINNRSGGADLEPLPSPPDVSAPSSQRGSTELSSQG 343

Query: 200 PT---VTEDVVGKV--------WYHGNLSREDAQALLKTEGD-----FLVRQSDHTPGKY 243
           P    + E VV K         W+HG +SR  A  L+++ G      FLVRQS+   G Y
Sbjct: 344 PAPLPMPEQVVQKTDHFLFSYPWFHGPISRVKAAYLVQSSGPEGHGVFLVRQSETRRGDY 403

Query: 244 VLSGRTAENEHKHLIL-LDNHNRVRTRDRTFSNISELIDY 282
           VL+    + + KHL L L    + R +   F ++ +++ +
Sbjct: 404 VLTF-NYQGKAKHLRLSLTEWGQCRVQHLRFPSVMDMLSH 442


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score = 43.5 bits (101), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 32/120 (26%), Positives = 61/120 (50%), Gaps = 13/120 (10%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDH 238
           R R +  +     N  AP  T  +  + WY G++ R DA+ LL      +G FL+R+S++
Sbjct: 103 RSRKNGKKGYIPGNYVAPIQT--LEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSEN 160

Query: 239 TPGK----YVLSGRTAEN-EHKHLILLDNHNRVRTRDRTFSNISELIDYH--VNNGMAVR 291
             G+    + LS R  E   H  + + D+     +  + FS ++ELI+++   ++G+ ++
Sbjct: 161 KNGQVSNCFALSVRDKELIRHYRIKITDSGKYFISLSKEFSTLNELIEFYKISSDGLKIK 220


>UniRef50_UPI00006A1A97 SH2B adapter protein 2 (SH2 and PH domain-containing adapter
           protein APS) (Adapter protein with pleckstrin homology
           and Src homology 2 domains). n=3 Tax=Xenopus (Silurana)
           tropicalis RepID=UPI00006A1A97
          Length = 591

 Score = 43.5 bits (101), Expect = 0.010,   Method: Compositional matrix adjust.
 Identities = 27/90 (30%), Positives = 49/90 (54%), Gaps = 7/90 (7%)

Query: 211 WYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHN 264
           W+HG LSR  A  L+     ++ G F++RQS+  PG+YVL+    + + KHL L L+   
Sbjct: 463 WFHGTLSRIRAAQLVLSGGTRSHGLFVIRQSETRPGEYVLT-FNFQGKAKHLRLSLNETG 521

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
           +   +   F  I +++ +  ++ + + S G
Sbjct: 522 QCHVQHLWFQTIFDMLKHFHSHPIPLESGG 551


>UniRef50_Q4TIA8 Chromosome undetermined SCAF2282, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4TIA8_TETNG
          Length = 209

 Score = 43.1 bits (100), Expect = 0.011,   Method: Compositional matrix adjust.
 Identities = 22/53 (41%), Positives = 32/53 (60%), Gaps = 1/53 (1%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL 257
           D+    WYHG++ RE ++ L+   GDFLVR S  + G +VL+ R  +NE  H 
Sbjct: 31  DIRSHGWYHGHIPREVSETLVLRNGDFLVRDSLTSVGDFVLTCR-WDNEALHF 82


>UniRef50_Q4SPM1 Chromosome 16 SCAF14537, whole genome shotgun sequence. (Fragment)
           n=6 Tax=Euteleostomi RepID=Q4SPM1_TETNG
          Length = 636

 Score = 43.1 bits (100), Expect = 0.012,   Method: Compositional matrix adjust.
 Identities = 27/80 (33%), Positives = 38/80 (47%), Gaps = 27/80 (33%)

Query: 194 VSNCRAPTVTED----------------------VVGKVWYHGNLSREDAQALL-----K 226
           VS CR PT T+D                      + G  W+HG LSR  A  L+     +
Sbjct: 372 VSLCRHPTQTDDRSGFRSQAGGSEGAKESEGDASLAGYPWFHGTLSRVRAAQLVLAGGAR 431

Query: 227 TEGDFLVRQSDHTPGKYVLS 246
           + G F++RQS+  PG+YVL+
Sbjct: 432 SHGLFVIRQSETRPGEYVLT 451


>UniRef50_C4Q974 Growth factor receptor-bound protein, putative n=2 Tax=Schistosoma
           RepID=C4Q974_SCHMA
          Length = 317

 Score = 43.1 bits (100), Expect = 0.013,   Method: Compositional matrix adjust.
 Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 11/84 (13%)

Query: 211 WYHGNLSREDAQA-LLKTE----------GDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
           WY    SR +A+A LL+T+          G F++RQS++ PG++ +S +   +     I 
Sbjct: 60  WYIPRCSRREAEARLLETDPDTNRDVQPDGAFILRQSENDPGQFSISVKEGSSVLHFRIF 119

Query: 260 LDNHNRVRTRDRTFSNISELIDYH 283
            D   +       F +I+ LIDYH
Sbjct: 120 FDPKGKYYIWTNKFDSINALIDYH 143


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score = 43.1 bits (100), Expect = 0.013,   Method: Compositional matrix adjust.
 Identities = 37/107 (34%), Positives = 53/107 (49%), Gaps = 16/107 (14%)

Query: 211 WYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRT----AENEHKHLILLDNH 263
           WY G++SR+ A++LLK    EG F+VR+S  T G Y LS  T    +  +H H+      
Sbjct: 410 WYVGDMSRQRAESLLKQGDKEGCFVVRKSS-TKGLYTLSLHTKVPQSHVKHYHIKQNARC 468

Query: 264 NRVRTRDRTFSNISELIDYHVNN--GMAVRSEGRDRETSLNLIRPVP 308
               +       I +LI+YH +N  G+A R +      S    RPVP
Sbjct: 469 EYYLSEKHCCETIPDLINYHRHNSGGLACRLK------SSPCDRPVP 509


>UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax=Brugia malayi
           RepID=A8P4D4_BRUMA
          Length = 428

 Score = 43.1 bits (100), Expect = 0.013,   Method: Compositional matrix adjust.
 Identities = 31/89 (34%), Positives = 46/89 (51%), Gaps = 7/89 (7%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPG--KYVLSGRTAENEH---KHLILLDN-HN 264
           +YHG L RED   LL  EGDFLVR S+  P   + V+     E      +H+++  N + 
Sbjct: 11  YYHGLLPREDLPHLLINEGDFLVRSSETAPNQPRQVIISILVEKRGAILRHIVVQQNAYG 70

Query: 265 RVRTRDR-TFSNISELIDYHVNNGMAVRS 292
           +  T  R +F ++ ELI ++   G  V S
Sbjct: 71  KYVTDARASFDSVPELIQFYQKCGEPVLS 99


>UniRef50_UPI00017B392D UPI00017B392D related cluster n=2 Tax=Tetraodon nigroviridis
           RepID=UPI00017B392D
          Length = 610

 Score = 43.1 bits (100), Expect = 0.013,   Method: Compositional matrix adjust.
 Identities = 30/107 (28%), Positives = 52/107 (48%), Gaps = 4/107 (3%)

Query: 211 WYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           W+HG LSR  A  L+     + G FLVRQS+   G+YVL+           + L+   + 
Sbjct: 467 WFHGTLSRLKAAQLVLGGPASHGVFLVRQSETRRGEYVLTFNFQGKAKALRLSLNEDGQC 526

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           R +   F +I +++++   + + + S G    T ++ +  V  PG D
Sbjct: 527 RVQHLWFQSIFDMLEHFRVHPIPLESGGASDVTLVSFVGAVRQPGRD 573


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score = 43.1 bits (100), Expect = 0.013,   Method: Compositional matrix adjust.
 Identities = 23/76 (30%), Positives = 41/76 (53%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLS-GRTAENEHKHLILLDNHNRVR 267
           W+H  +SRE+ + LL  K +G FLVR+S + PG + L      + EH  +          
Sbjct: 148 WFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMAYHGKVEHYRIEQTSGGQLTC 207

Query: 268 TRDRTFSNISELIDYH 283
            ++  FSN+++L+ ++
Sbjct: 208 DKEEYFSNLTQLVSHY 223


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score = 43.1 bits (100), Expect = 0.014,   Method: Compositional matrix adjust.
 Identities = 24/86 (27%), Positives = 50/86 (58%), Gaps = 6/86 (6%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           W+HG ++RE A+ LL     G FLVR+S + PG Y L   + + + +H  ++ + +++  
Sbjct: 82  WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLC-VSCDGKVEHYRIMYHASKLSI 140

Query: 269 RDRT-FSNISELIDYHVN--NGMAVR 291
            +   F N+ +L++++ +  +G+  R
Sbjct: 141 DEEVYFENLMQLVEHYTSDADGLCTR 166


>UniRef50_UPI000179134F PREDICTED: similar to signal transduction protein lnk-realted,
           partial n=1 Tax=Acyrthosiphon pisum RepID=UPI000179134F
          Length = 474

 Score = 43.1 bits (100), Expect = 0.014,   Method: Compositional matrix adjust.
 Identities = 26/78 (33%), Positives = 45/78 (57%), Gaps = 7/78 (8%)

Query: 211 WYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL-ILLDNHN 264
           W+HG L+R DA  L+        G FLVRQS+   G+YVL+    + + KHL + L++  
Sbjct: 297 WFHGMLARSDATNLVSHLGTNGHGMFLVRQSETRKGEYVLTF-NFKGKPKHLRMTLNDQG 355

Query: 265 RVRTRDRTFSNISELIDY 282
             R +  +F +I +++++
Sbjct: 356 HCRVQHLSFPSIQDMLEH 373


>UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1 Tax=Tribolium
           castaneum RepID=D2A4V7_TRICA
          Length = 488

 Score = 42.7 bits (99), Expect = 0.015,   Method: Compositional matrix adjust.
 Identities = 26/92 (28%), Positives = 49/92 (53%), Gaps = 7/92 (7%)

Query: 209 KVWYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL-ILLDN 262
           + W+HG L R +A  L+     +  G FLVRQS+   G++VL+    +   KHL + +++
Sbjct: 320 EFWFHGTLGRSEATNLVLHDGARGHGLFLVRQSETRTGEFVLT-FNFQGRAKHLRMTIND 378

Query: 263 HNRVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
             + R +   F +I E++++     + + S G
Sbjct: 379 QGQCRVQHFWFQSIYEMLEHFRQQPIPLESGG 410


>UniRef50_A1L2D2 Src homology 2 domain containing transforming protein D n=8
           Tax=Clupeocephala RepID=A1L2D2_DANRE
          Length = 391

 Score = 42.7 bits (99), Expect = 0.015,   Method: Compositional matrix adjust.
 Identities = 27/87 (31%), Positives = 44/87 (50%), Gaps = 4/87 (4%)

Query: 209 KVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAEN--EHKHLILLDNHN 264
           +VWYHG+LSR +A++LL    E  +LVR S+ +   Y LS R+ +     K     D   
Sbjct: 289 QVWYHGSLSRSEAESLLTLCKECSYLVRNSETSRLDYSLSLRSCQGFMHMKFSQCKDGRY 348

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVR 291
            +      F  I E+I Y+  + + ++
Sbjct: 349 ILGQNSPPFETIPEVIHYYTTHKLPIK 375


>UniRef50_UPI00015B496D PREDICTED: similar to conserved hypothetical protein n=3
            Tax=Coelomata RepID=UPI00015B496D
          Length = 1182

 Score = 42.7 bits (99), Expect = 0.016,   Method: Compositional matrix adjust.
 Identities = 27/92 (29%), Positives = 49/92 (53%), Gaps = 17/92 (18%)

Query: 211  WYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTA---------ENEHKHLIL 259
            WYHG+++R +A+A+L+   EG +LVR S+ T   Y LS ++A         +NE  +  +
Sbjct: 1081 WYHGSITRIEAEAVLRLLREGSYLVRNSESTKQDYSLSLKSARGFMHMRIQKNEELNAYI 1140

Query: 260  LDNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
            L   +      + F +I E++ +   N + +R
Sbjct: 1141 LGQFS------KPFDSIPEMVRHFSINRLPIR 1166


>UniRef50_Q9XYM0 Adapter molecule Crk n=8 Tax=Endopterygota RepID=CRK_DROME
          Length = 271

 Score = 42.7 bits (99), Expect = 0.016,   Method: Compositional matrix adjust.
 Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 6/79 (7%)

Query: 211 WYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLSGRTAENEHKHLI-LLDNHNRV 266
           WY G +SR+DA  +L  E   G FLVR S+   G YVL  R       ++I  +   +++
Sbjct: 12  WYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQI 71

Query: 267 --RTRDRTFSNISELIDYH 283
             R  D++F N+ +L+ ++
Sbjct: 72  VYRIGDQSFDNLPKLLTFY 90


>UniRef50_B8JL24 Novel protein similar to human and mouse SH2 domain containing 4B
           (SH2D4B) n=2 Tax=Danio rerio RepID=B8JL24_DANRE
          Length = 441

 Score = 42.7 bits (99), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 29/78 (37%), Positives = 44/78 (56%), Gaps = 7/78 (8%)

Query: 211 WYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKHLIL---LDNHNR 265
           W+HG +SRED++ LL     G FLVR S+   G Y LS RTA    KH ++    D ++ 
Sbjct: 344 WFHGIISREDSETLLMNAAVGSFLVRVSERIWG-YTLSYRTASG-FKHFLIDASGDYYSF 401

Query: 266 VRTRDRTFSNISELIDYH 283
           +       + +++LID+H
Sbjct: 402 LGVDQNRHATLADLIDFH 419


>UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeocephala
           RepID=B5X4M4_SALSA
          Length = 430

 Score = 42.7 bits (99), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 31/84 (36%), Positives = 51/84 (60%), Gaps = 20/84 (23%)

Query: 211 WYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLSGRTAENEHKHLI--------L 259
           W+HG +SR++A+ LL +EG+   FLVR S+   G YVLS R  ++E KH +        +
Sbjct: 325 WFHGIISRQEAEDLL-SEGEPGHFLVRVSERILG-YVLSYR-CKDEFKHFLIDATEGCYM 381

Query: 260 LDNHNRVRTRDRTFSNISELIDYH 283
           L  H  +R     F++++EL+++H
Sbjct: 382 LLGHQ-IR-----FTSLAELVEFH 399


>UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform 2 n=1 Tax=Apis mellifera
            RepID=UPI0000DB713D
          Length = 1122

 Score = 42.7 bits (99), Expect = 0.018,   Method: Compositional matrix adjust.
 Identities = 27/92 (29%), Positives = 49/92 (53%), Gaps = 17/92 (18%)

Query: 211  WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTA---------ENEHKHLIL 259
            WYHG+++R +A+A+L+   EG +LVR S+ T   Y LS ++A         +NE  +  +
Sbjct: 1021 WYHGSITRIEAEAVLRLLREGSYLVRNSESTKQDYSLSLKSARGFMHMRIQKNEELNAYI 1080

Query: 260  LDNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
            L   +      + F +I E++ +   N + +R
Sbjct: 1081 LGQFS------KPFDSIPEMVRHFSVNRLPIR 1106


>UniRef50_Q56A36 Hematopoietic SH2 domain-containing protein homolog n=3 Tax=Danio
           rerio RepID=HSH2D_DANRE
          Length = 365

 Score = 42.7 bits (99), Expect = 0.018,   Method: Compositional matrix adjust.
 Identities = 32/108 (29%), Positives = 56/108 (51%), Gaps = 7/108 (6%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDH 238
           P+ + SS    S+ +  +   + E+ V   W+HG +SR+ A+ +L  K  G FL+R S+ 
Sbjct: 4   PLPNDSSNAAFSWFTEYQRSCILENGVVPEWFHGIISRKAAEEMLMCKPAGYFLIRVSES 63

Query: 239 TPGKYVLSGRTAENEHKHL---ILLDNHNRVRTRDRTFSNISELIDYH 283
             G Y LS R AE+  +H    +L DN   +      + ++ +L+ +H
Sbjct: 64  RVG-YTLSYR-AEDRCRHFMINVLPDNQFMIVGEKTVYCSLHDLVAFH 109


>UniRef50_Q7K137 Lnk, isoform A n=13 Tax=Drosophila RepID=Q7K137_DROME
          Length = 723

 Score = 42.7 bits (99), Expect = 0.019,   Method: Compositional matrix adjust.
 Identities = 27/90 (30%), Positives = 48/90 (53%), Gaps = 7/90 (7%)

Query: 211 WYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHN 264
           W+HG L+R +A  ++        G FLVRQS+   G++VL+    +   KHL L +    
Sbjct: 442 WFHGTLTRSEAARMVLHSDAAGHGYFLVRQSETRRGEFVLT-FNFQGRAKHLRLTISEKG 500

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
           + R +   F +I E++++  +N + + S G
Sbjct: 501 QCRVQHLWFPSIQEMLEHFRHNPIPLESGG 530


>UniRef50_Q29CU6 GA13993 n=10 Tax=Neoptera RepID=Q29CU6_DROPS
          Length = 297

 Score = 42.7 bits (99), Expect = 0.019,   Method: Compositional matrix adjust.
 Identities = 26/79 (32%), Positives = 43/79 (54%), Gaps = 6/79 (7%)

Query: 211 WYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLSGRTAENEHKHLI-LLDNHNRV 266
           WY G +SR+DA  +L  E   G FLVR S+   G YVL  R       ++I  +   +++
Sbjct: 12  WYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQI 71

Query: 267 --RTRDRTFSNISELIDYH 283
             R  D++F N+ +L+ ++
Sbjct: 72  VYRIGDQSFDNLPKLLTFY 90


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score = 42.4 bits (98), Expect = 0.020,   Method: Compositional matrix adjust.
 Identities = 24/76 (31%), Positives = 44/76 (57%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I   +  ++  
Sbjct: 379 WYHGPVSRNAAEHLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 438

Query: 268 TRDRTFSNISELIDYH 283
           + +  F+ ++EL+ +H
Sbjct: 439 SSESRFNTLAELVHHH 454


>UniRef50_UPI000192628F PREDICTED: similar to chimerin (chimaerin) 1, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI000192628F
          Length = 444

 Score = 42.4 bits (98), Expect = 0.020,   Method: Compositional matrix adjust.
 Identities = 22/71 (30%), Positives = 39/71 (54%), Gaps = 2/71 (2%)

Query: 212 YHGNLSREDAQAL-LKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR-TR 269
           +HG +SRE+A+ L +K EG +L R+S+  PG Y L+ R       + +  D   ++    
Sbjct: 81  FHGAISREEAEKLVMKDEGCYLTRESERLPGTYALTFRFNNAPKNYRLYYDTDEKMHFVG 140

Query: 270 DRTFSNISELI 280
           ++ F  I +L+
Sbjct: 141 EKQFETIHDLV 151


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score = 42.4 bits (98), Expect = 0.020,   Method: Compositional matrix adjust.
 Identities = 24/76 (31%), Positives = 44/76 (57%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I   +  ++  
Sbjct: 466 WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYV 525

Query: 268 TRDRTFSNISELIDYH 283
           + +  F+ ++EL+ +H
Sbjct: 526 SSESRFNTLAELVHHH 541


>UniRef50_A8Q767 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8Q767_BRUMA
          Length = 500

 Score = 42.4 bits (98), Expect = 0.021,   Method: Compositional matrix adjust.
 Identities = 32/119 (26%), Positives = 61/119 (51%), Gaps = 25/119 (21%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSD---HTPGKYVLSGRTAENEH----KHLI 258
           V+ + +YHG L RED   LL+  GDF++R +      P + +LS R ++       +H++
Sbjct: 22  VLDESYYHGFLPREDLPCLLEQVGDFIIRITQLKPRDPCELILSLRVSDQNSPSAIRHVV 81

Query: 259 LLDNHNRVRTRD----------RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           +    +R++ +D            F+++ ELID +V++   +  E +    +  LIRP+
Sbjct: 82  I----HRLKGKDGKIEWLTNQENRFNSLKELIDAYVSSKKPINPEIK----TSQLIRPI 132


>UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA
          Length = 266

 Score = 42.4 bits (98), Expect = 0.021,   Method: Compositional matrix adjust.
 Identities = 30/97 (30%), Positives = 46/97 (47%), Gaps = 10/97 (10%)

Query: 197 CRAPTVTEDVVGKVWYHGNLSREDAQALLKT----EGDFLVRQSDHTPGKYVLSGR---- 248
           C  PT     V   W +  ++RE A+ LL       G FL+R+S+   G Y LS R    
Sbjct: 75  CYLPTNYVAKVCNRWLYKGINREKAEELLMVNSNRSGSFLIRESETRSGSYTLSIRKTNH 134

Query: 249 TAENEHKHLIL--LDNHNRVRTRDRTFSNISELIDYH 283
           T+ +  KH  +  LDN         TF+ + +++DY+
Sbjct: 135 TSRDSIKHYRIHQLDNGWFYIAPRLTFATLQDMVDYY 171


>UniRef50_A2RUZ0 Zgc:158474 protein n=2 Tax=Euteleostomi RepID=A2RUZ0_DANRE
          Length = 906

 Score = 42.4 bits (98), Expect = 0.022,   Method: Compositional matrix adjust.
 Identities = 27/78 (34%), Positives = 44/78 (56%), Gaps = 7/78 (8%)

Query: 211 WYHGNLSREDAQAL-----LKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHN 264
           W+HG LSR  A  L     + + G FLVRQS+   G+YVL+    + + KHL L L+   
Sbjct: 715 WFHGTLSRLKAAQLVLAGGMASHGVFLVRQSETRRGEYVLT-FNFQGKAKHLRLSLNEDG 773

Query: 265 RVRTRDRTFSNISELIDY 282
           + R +   F +I +++++
Sbjct: 774 QCRVQHLWFQSIFDMLEH 791


>UniRef50_C3Y4J7 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae
           RepID=C3Y4J7_BRAFL
          Length = 442

 Score = 42.4 bits (98), Expect = 0.023,   Method: Compositional matrix adjust.
 Identities = 17/37 (45%), Positives = 28/37 (75%), Gaps = 3/37 (8%)

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSG 247
           W+HG ++R+ A+ LL+ +GDFLVR+S+    KY ++G
Sbjct: 324 WFHGPMTRKQAEELLEEDGDFLVRESER---KYDITG 357


>UniRef50_Q2I6J0 Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2B n=7
           Tax=Clupeocephala RepID=SHP2B_DANRE
          Length = 1226

 Score = 42.4 bits (98), Expect = 0.023,   Method: Compositional matrix adjust.
 Identities = 23/59 (38%), Positives = 31/59 (52%), Gaps = 3/59 (5%)

Query: 206 VVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
           + G  WYH ++SR  A+ LL     +G FLVR S+  PG Y L      + H + IL D
Sbjct: 1   MTGAPWYHRDISRVRAEELLAHAGIDGSFLVRDSESVPGAYALCLLFQRHVHTYRILPD 59


>UniRef50_Q9JID9 SH2B adapter protein 2 n=13 Tax=Euteleostomi RepID=SH2B2_MOUSE
          Length = 621

 Score = 42.4 bits (98), Expect = 0.024,   Method: Compositional matrix adjust.
 Identities = 26/90 (28%), Positives = 49/90 (54%), Gaps = 7/90 (7%)

Query: 211 WYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHN 264
           W+HG LSR  A  L+     ++ G F++RQS+  PG+ VL+    + + KHL L L+ H 
Sbjct: 409 WFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLT-FNFQGKAKHLRLSLNGHG 467

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
           +   +   F ++ +++ +   + + + S G
Sbjct: 468 QCHVQHLWFQSVFDMLRHFHTHPIPLESGG 497


>UniRef50_Q21429 Protein K11E4.2, confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q21429_CAEEL
          Length = 272

 Score = 42.0 bits (97), Expect = 0.025,   Method: Compositional matrix adjust.
 Identities = 58/263 (22%), Positives = 110/263 (41%), Gaps = 40/263 (15%)

Query: 9   AEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINPVV 68
           A+ + +SG   +  Y+G  P++++I       R  +V  CI  V ++    A  E + + 
Sbjct: 17  AKHVNASGDRFAVKYMGYAPILQTIRERPIADRDALVRHCINTVVSS---RATHEYSVIQ 73

Query: 69  SR-VIGE-VKKENFPVDINISSKMIKIIK----QSRLIQRHP---FSFFSFGAQGQKGTD 119
              V+G  V      + +NISS  I        ++ L+ R+     S + +     +  D
Sbjct: 74  HEGVVGPYVSVYQLDLFLNISSFTITCFHIQDGRTHLLGRYKNNQISHYKY-----REID 128

Query: 120 TELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPA 179
                G + K      R C+V  +++   L D+ T   +V+                   
Sbjct: 129 GRHYLGIVMKIGRTEKRECNVFMLDNDIALNDLTTKLRSVDE------------------ 170

Query: 180 PPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHT 239
              RH ++L  ++ + + +    T +++    YHG LS EDA   L   G+F++R S   
Sbjct: 171 --RRHNNALQLETRLRSTQEYRYTPNMLA--CYHGPLSHEDACRQLVLPGEFIIRDSS-M 225

Query: 240 PGKYVLSGRTAENEHKHLILLDN 262
            G++ +S +T+   H   I+ +N
Sbjct: 226 RGEFAVSYKTSHGPHDKSIVPNN 248


>UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax=Euteleostomi
           RepID=SHB_HUMAN
          Length = 509

 Score = 42.0 bits (97), Expect = 0.026,   Method: Compositional matrix adjust.
 Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 8/102 (7%)

Query: 209 KVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAEN-EHKHLILLDNHNR 265
           ++WYHG +SR DA+ LL+   E  +LVR S  +   Y LS R+ +   H  L        
Sbjct: 408 QIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYV 467

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           +      F ++ E+I Y+    + ++         L+L+ PV
Sbjct: 468 LGQNSPPFDSVPEVIHYYTTRKLPIKG-----AEHLSLLYPV 504


>UniRef50_Q7YSY1 Fes-like tyrosine kinase protein n=5 Tax=Schistosoma mansoni
           RepID=Q7YSY1_SCHMA
          Length = 1259

 Score = 42.0 bits (97), Expect = 0.027,   Method: Compositional matrix adjust.
 Identities = 34/122 (27%), Positives = 48/122 (39%), Gaps = 37/122 (30%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQ-SDHTPGKYVL------SGRTAEN 252
           P    D+  + W+HG L R + + LL+ +GDFLVRQ S  + G+  +      +G     
Sbjct: 810 PICDMDINKEPWFHGVLPRAEVERLLQNQGDFLVRQTSKRSSGRDTIGHWNGTNGDLING 869

Query: 253 EHKHLILLDNHNRVRT------------------------------RDRTFSNISELIDY 282
            H   IL  +HN   T                               D  FS I ELI+Y
Sbjct: 870 NHNETILNKDHNMDGTVLRMVLSVFWHGHRHFILYGGPETGEGWHLEDGHFSTIRELIEY 929

Query: 283 HV 284
           H+
Sbjct: 930 HM 931


>UniRef50_C3YQJ2 Putative uncharacterized protein n=4 Tax=Branchiostoma floridae
           RepID=C3YQJ2_BRAFL
          Length = 453

 Score = 42.0 bits (97), Expect = 0.027,   Method: Compositional matrix adjust.
 Identities = 22/41 (53%), Positives = 28/41 (68%), Gaps = 4/41 (9%)

Query: 211 WYHGNLSREDAQALLKTE--GDFLVRQSDHTPGK-YVLSGR 248
           WYHG +SREDA+  LK    G FL+RQS   PGK ++LS +
Sbjct: 253 WYHGMMSREDAEVKLKQAGVGSFLIRQS-QRPGKGFILSAK 292


>UniRef50_C4Q4A1 Term=tyrosine kinase
           5;db_xref=PMID:11289068;with=UniProt:Q9NH62;evidence=tra
           cea ble author statement n=2 Tax=Schistosoma mansoni
           RepID=C4Q4A1_SCHMA
          Length = 653

 Score = 42.0 bits (97), Expect = 0.027,   Method: Compositional matrix adjust.
 Identities = 33/113 (29%), Positives = 52/113 (46%), Gaps = 22/113 (19%)

Query: 211 WYHGNLSREDAQALLKTEGD----FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           W+   LSR+D++ LL  EG+    FLVR+S+ + G   LS R  E     ++    H R+
Sbjct: 179 WFMPMLSRKDSERLLLLEGNAQGVFLVRESETSQGSLTLSVRDEERGLSGIMNTVKHYRI 238

Query: 267 RTRDR---------TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
           +  D          +FS++ ELI ++     ++ S G        L R   CP
Sbjct: 239 KHPDYRYYYITTKCSFSSLQELIQFY-----SIDSHG----LCCKLTRACLCP 282


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score = 42.0 bits (97), Expect = 0.028,   Method: Compositional matrix adjust.
 Identities = 31/104 (29%), Positives = 52/104 (50%), Gaps = 14/104 (13%)

Query: 211 WYHGNLSREDAQALL---KTEGDFLVRQSDHTP--GKYVLSGRTAENEHKHLILLDNHNR 265
           WY G +SR+ A+  L    ++G F++R S+  P  G + LS +  +      IL D   +
Sbjct: 62  WYVGKISRKVAEEYLMSMPSDGAFMIRDSESNPDSGNFSLSVKFRDQVQHFKILTDLAGK 121

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                  F++I++L+DYH +N ++     R +E  LN     PC
Sbjct: 122 YFLWVVKFTSINDLVDYHKDNSVS-----RTQEIVLN----EPC 156


>UniRef50_UPI00015B5375 PREDICTED: similar to tensin n=1 Tax=Nasonia vitripennis
           RepID=UPI00015B5375
          Length = 1147

 Score = 42.0 bits (97), Expect = 0.029,   Method: Compositional matrix adjust.
 Identities = 31/102 (30%), Positives = 50/102 (49%), Gaps = 20/102 (19%)

Query: 209 KVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAE-------------NE 253
           K+WY  N+SRE A A+L+    G F+VR S+  PG + L+ + A+             NE
Sbjct: 860 KIWYKPNISREQAIAMLRDAAPGTFVVRDSNSFPGAFGLALKVAQPPPGAPSSPKDPSNE 919

Query: 254 H-KHLILLDNHNRVRTR----DRTFSNISELIDYHVNNGMAV 290
             +H ++      VR +    +  FS++S L+  H    MA+
Sbjct: 920 LVRHFLIEPTSRGVRLKGCANEPVFSSLSALVYQHSLMAMAL 961


>UniRef50_Q4RP74 Chromosome 1 SCAF15008, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4RP74_TETNG
          Length = 968

 Score = 42.0 bits (97), Expect = 0.029,   Method: Compositional matrix adjust.
 Identities = 22/55 (40%), Positives = 30/55 (54%), Gaps = 3/55 (5%)

Query: 210 VWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
           VWYH ++SR  A+ LL     +G +LVR S+  PG Y L      + H + IL D
Sbjct: 13  VWYHRDISRVQAEELLARAGKDGSYLVRDSESVPGAYALCLLFQRHVHTYRILPD 67


>UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistosoma
           RepID=Q5BXT3_SCHJA
          Length = 190

 Score = 42.0 bits (97), Expect = 0.030,   Method: Compositional matrix adjust.
 Identities = 24/76 (31%), Positives = 40/76 (52%), Gaps = 3/76 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           WYHG +SR+  + LL++   G FLVR S+  PG+  ++ R     + + I  D+      
Sbjct: 78  WYHGAVSRQAGEHLLRSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGLFYI 137

Query: 268 TRDRTFSNISELIDYH 283
           T    F  + +LI++H
Sbjct: 138 TEAHRFPTVVQLIEHH 153


>UniRef50_D2HL11 Putative uncharacterized protein (Fragment) n=4 Tax=Laurasiatheria
           RepID=D2HL11_AILME
          Length = 429

 Score = 42.0 bits (97), Expect = 0.031,   Method: Compositional matrix adjust.
 Identities = 24/76 (31%), Positives = 41/76 (53%), Gaps = 4/76 (5%)

Query: 192 SFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRT 249
           ++ +  +AP + +D     W+HG ++R+  + LL  K  G FL+R SD   G Y+LS R 
Sbjct: 24  TWFTETQAPLILQDGALPPWFHGFITRKQTEQLLGDKALGSFLIRLSDRATG-YILSYR- 81

Query: 250 AENEHKHLILLDNHNR 265
             +  +H ++    NR
Sbjct: 82  GSDRCRHFVINQLQNR 97


>UniRef50_UPI0000E49A5A PREDICTED: similar to protein-tyrosine kinase HTK98 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A5A
          Length = 746

 Score = 42.0 bits (97), Expect = 0.031,   Method: Compositional matrix adjust.
 Identities = 35/121 (28%), Positives = 59/121 (48%), Gaps = 12/121 (9%)

Query: 178 PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT----EGDFLV 233
           P P + H    + Q  V   R   V  D + + +YHG ++RE+A+A L+     +G FL+
Sbjct: 28  PTPKINHH---YHQQLVQPGRIMPV--DPLSRRFYHGRITREEAEARLRNAGCHQGMFLL 82

Query: 234 RQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD-RTFSNISELIDYHVN--NGMAV 290
           R+S    G Y LS    ++ + + I       V  +D + F+   EL+  H+N  +G+  
Sbjct: 83  RESLGREGNYALSLCYEDDVYHYAIERQYDGTVAIKDGKNFAGPIELVSNHMNREDGLLC 142

Query: 291 R 291
           R
Sbjct: 143 R 143


>UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME
          Length = 506

 Score = 41.6 bits (96), Expect = 0.034,   Method: Compositional matrix adjust.
 Identities = 29/99 (29%), Positives = 57/99 (57%), Gaps = 6/99 (6%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WY G +SRE+A+++L  K +G FLVR +    G+Y L+    ++  + LI + + +R   
Sbjct: 32  WYWGRISREEAKSILHGKPDGSFLVRDALSMKGEYTLT--LMKDGCEKLIKICHMDRKYG 89

Query: 269 RDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
              T  F+++ E+I+Y+  N +++ ++  D   S  ++R
Sbjct: 90  FIETDLFNSVVEMINYYKENSLSMYNKTLDITLSNPIVR 128


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score = 41.6 bits (96), Expect = 0.035,   Method: Compositional matrix adjust.
 Identities = 24/78 (30%), Positives = 42/78 (53%), Gaps = 5/78 (6%)

Query: 211 WYHGNLSREDAQALLKTE----GDFLVRQSDHTPGKYVLSGRTAEN-EHKHLILLDNHNR 265
           W+ G + R +A+ +L       G FL+R S+ TPG + LS +  +   H  +  L++ + 
Sbjct: 122 WFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPGDFSLSVKDQDRVRHYRVRRLEDGSL 181

Query: 266 VRTRDRTFSNISELIDYH 283
             TR  TF  + EL+D++
Sbjct: 182 FVTRRSTFQILHELVDHY 199


>UniRef50_Q08BW5 Cytokine inducible SH2 containing protein n=2 Tax=Danio rerio
           RepID=Q08BW5_DANRE
          Length = 212

 Score = 41.6 bits (96), Expect = 0.036,   Method: Compositional matrix adjust.
 Identities = 30/121 (24%), Positives = 55/121 (45%), Gaps = 21/121 (17%)

Query: 211 WYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAEN------EHKHL-ILLD 261
           WY G +S  +A ++LK  +EG FL+R S H      LS +T         E++     LD
Sbjct: 51  WYWGGISASEAHSVLKGASEGTFLIRDSSHPDYMLTLSVKTVRGPTNVRIEYRQCRFSLD 110

Query: 262 NHNRVRTRDRTFSNISELIDYHVNNG------------MAVRSEGRDRETSLNLIRPVPC 309
           + +  R+  ++F ++  L+ ++V +               + S  ++    L L +P+ C
Sbjct: 111 SSSPARSHLQSFPDVHSLVQHYVGSKSEKNEEKMEEAHHVISSAPKECSVLLKLKKPIHC 170

Query: 310 P 310
           P
Sbjct: 171 P 171


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q9TYT3 Putative uncharacterized protein n=4 Tax=Caenorh...   455   e-126
UniRef50_A8WZ72 C. briggsae CBR-SHC-1 protein n=2 Tax=Caenorhabd...   370   e-101
UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming pr...   316   8e-85
UniRef50_Q6NPB1 RH57813p n=16 Tax=Neoptera RepID=Q6NPB1_DROME         271   2e-71
UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2...   189   1e-46
UniRef50_A7RR81 Predicted protein n=1 Tax=Nematostella vectensis...   179   1e-43
UniRef50_B4IYA5 GH15138 n=5 Tax=Drosophila RepID=B4IYA5_DROGR         174   4e-42
UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein...   170   7e-41
UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain pr...   160   5e-38
UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi...   156   9e-37
UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=...   155   2e-36
UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi...   155   2e-36
UniRef50_A9V4N6 Predicted protein n=1 Tax=Monosiga brevicollis R...   154   3e-36
UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi...   151   2e-35
UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=...   151   3e-35
UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda Rep...   149   1e-34
UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Ta...   140   8e-32
UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Siluran...   137   6e-31
UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=...   136   1e-30
UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=S...   135   2e-30
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...   134   6e-30
UniRef50_UPI0001A5EB2D PREDICTED: hypothetical protein XP_002347...   133   1e-29
UniRef50_B3RQY3 Putative uncharacterized protein n=1 Tax=Trichop...   130   7e-29
UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein...   129   2e-28
UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76...   126   1e-27
UniRef50_UPI00019269FE PREDICTED: similar to protein tyrosine ph...   125   3e-27
UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=...   125   3e-27
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...   124   3e-27
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...   124   5e-27
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...   124   6e-27
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...   122   1e-26
UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, part...   122   1e-26
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...   122   1e-26
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...   121   3e-26
UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID...   120   5e-26
UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group Rep...   119   1e-25
UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 ...   119   1e-25
UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS         119   2e-25
UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putativ...   119   2e-25
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   118   3e-25
UniRef50_UPI00006A1C31 UPI00006A1C31 related cluster n=1 Tax=Xen...   117   4e-25
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...   117   4e-25
UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pe...   117   5e-25
UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, part...   117   5e-25
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...   117   5e-25
UniRef50_B0WI58 Putative uncharacterized protein n=2 Tax=Culicin...   116   9e-25
UniRef50_UPI00006A1C30 UPI00006A1C30 related cluster n=1 Tax=Xen...   116   1e-24
UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Tak...   116   1e-24
UniRef50_A8P596 SH2 domain containing protein n=1 Tax=Brugia mal...   115   2e-24
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...   115   2e-24
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   115   2e-24
UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9...   114   3e-24
UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=...   114   3e-24
UniRef50_A8WHN9 Novel protein similar to vertebrate breast cance...   114   3e-24
UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eu...   114   4e-24
UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3...   114   4e-24
UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia mal...   114   5e-24
UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun se...   114   6e-24
UniRef50_B7PEL7 Signal transduction protein lnk-realted, putativ...   113   8e-24
UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes relate...   113   9e-24
UniRef50_Q8AVM4 Sh2d3c-prov protein n=7 Tax=Euteleostomi RepID=Q...   113   1e-23
UniRef50_Q4S6Q5 Chromosome undetermined SCAF14724, whole genome ...   112   2e-23
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...   112   2e-23
UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio Rep...   112   2e-23
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   112   2e-23
UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4...   112   2e-23
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...   111   4e-23
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...   111   4e-23
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   110   5e-23
UniRef50_UPI0000DB7594 PREDICTED: similar to CG9098-PA, isoform ...   110   5e-23
UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax...   110   5e-23
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...   110   6e-23
UniRef50_A2AK86 SH2 domain containing 3C (Fragment) n=4 Tax=Eute...   110   6e-23
UniRef50_UPI000186DA97 tyrosine-protein kinase transforming prot...   110   7e-23
UniRef50_Q59HB0 SHC (Src homology 2 domain containing) transform...   110   7e-23
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          110   8e-23
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          110   9e-23
UniRef50_UPI00006A5E95 PREDICTED: similar to HrSH2 n=1 Tax=Ciona...   110   9e-23
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...   109   1e-22
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   109   1e-22
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...   109   1e-22
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   109   1e-22
UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activati...   109   2e-22
UniRef50_UPI00015B5D64 PREDICTED: similar to LD41184p n=1 Tax=Na...   109   2e-22
UniRef50_Q8N5H7 SH2 domain-containing protein 3C n=39 Tax=Amniot...   109   2e-22
UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS         109   2e-22
UniRef50_Q5T189 SHC (Src homology 2 domain containing) transform...   109   2e-22
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...   108   3e-22
UniRef50_Q4SMI9 Chromosome 18 SCAF14547, whole genome shotgun se...   108   3e-22
UniRef50_UPI00017B1E0A UPI00017B1E0A related cluster n=1 Tax=Tet...   107   4e-22
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   107   4e-22
UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus...   107   5e-22
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   107   6e-22
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...   107   8e-22
UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pe...   106   1e-21
UniRef50_A2BDR5 SH2 domain containing 3C (Fragment) n=4 Tax=Eute...   106   1e-21
UniRef50_UPI0000612FE6 UPI0000612FE6 related cluster n=1 Tax=Bos...   106   1e-21
UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus ...   106   1e-21
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...   105   2e-21
UniRef50_Q9BRG2 SH2 domain-containing protein 3A n=12 Tax=Euther...   105   2e-21
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...   105   2e-21
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...   105   2e-21
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...   104   7e-21
UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorh...   104   7e-21
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   103   9e-21
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   102   2e-20
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   101   3e-20
UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME       101   3e-20
UniRef50_UPI00015B58E2 PREDICTED: similar to signal transduction...   100   5e-20
UniRef50_UPI000192756A PREDICTED: similar to predicted protein n...   100   5e-20
UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephyd...   100   6e-20
UniRef50_Q18684 Protein T13H10.1, confirmed by transcript eviden...   100   7e-20
UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein ...   100   1e-19
UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein act...    99   2e-19
UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2...    98   4e-19
UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O...    98   4e-19
UniRef50_Q4SW52 Chromosome undetermined SCAF13690, whole genome ...    98   4e-19
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...    98   5e-19
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...    97   1e-18
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...    96   1e-18
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...    96   2e-18
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...    96   2e-18
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...    96   2e-18
UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE       96   2e-18
UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidenc...    95   4e-18
UniRef50_A7RZ47 Predicted protein n=1 Tax=Nematostella vectensis...    94   4e-18
UniRef50_UPI00017925DF PREDICTED: similar to CG11146 CG11146-PA ...    94   7e-18
UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n...    94   7e-18
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...    93   1e-17
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...    93   1e-17
UniRef50_Q9XXE5 Protein Y43C5B.2, partially confirmed by transcr...    92   3e-17
UniRef50_C3XYL7 Putative uncharacterized protein n=2 Tax=Branchi...    91   4e-17
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...    91   5e-17
UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis R...    90   8e-17
UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine ki...    90   1e-16
UniRef50_A8WMP8 Putative uncharacterized protein n=1 Tax=Caenorh...    90   1e-16

Sequences not found previously or not previously below threshold:

UniRef50_Q3ZAX3 Shc3 protein n=9 Tax=Euteleostomi RepID=Q3ZAX3_M...   157   6e-37
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...   119   1e-25
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...   110   6e-23
UniRef50_Q7K137 Lnk, isoform A n=13 Tax=Drosophila RepID=Q7K137_...   109   1e-22
UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria...   109   2e-22
UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_D...   107   4e-22
UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA    107   7e-22
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...   106   9e-22
UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateri...   106   1e-21
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...   105   2e-21
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   105   2e-21
UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6...   105   3e-21
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   105   3e-21
UniRef50_B7QIL2 Dreadlocks/dock, putative (Fragment) n=1 Tax=Ixo...   105   3e-21
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...   104   3e-21
UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambi...   104   3e-21
UniRef50_UPI00017B2C65 UPI00017B2C65 related cluster n=1 Tax=Tet...   104   6e-21
UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup...   103   9e-21
UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1...   102   1e-20
UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU...   102   2e-20
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...   102   2e-20
UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate p...   102   2e-20
UniRef50_UPI00017B392D UPI00017B392D related cluster n=2 Tax=Tet...   102   2e-20
UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related ad...   101   3e-20
UniRef50_UPI000179134F PREDICTED: similar to signal transduction...   101   3e-20
UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS         101   3e-20
UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=S...   101   3e-20
UniRef50_O14492 SH2B adapter protein 2 n=4 Tax=Catarrhini RepID=...   101   3e-20
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   100   5e-20
UniRef50_A2RUZ0 Zgc:158474 protein n=2 Tax=Euteleostomi RepID=A2...   100   5e-20
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...   100   5e-20
UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicin...   100   5e-20
UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homo...   100   6e-20
UniRef50_UPI00016E9884 UPI00016E9884 related cluster n=7 Tax=Tak...   100   1e-19
UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA ...   100   1e-19
UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1...    99   2e-19
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...    99   2e-19
UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specif...    99   2e-19
UniRef50_UPI00006A1A97 SH2B adapter protein 2 (SH2 and PH domain...    99   2e-19
UniRef50_A9UWT7 Predicted protein n=1 Tax=Monosiga brevicollis R...    98   3e-19
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...    98   4e-19
UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gam...    98   4e-19
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...    98   4e-19
UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X...    98   5e-19
UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic regio...    98   5e-19
UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform ...    98   5e-19
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...    98   5e-19
UniRef50_Q9JID9 SH2B adapter protein 2 n=13 Tax=Euteleostomi Rep...    97   5e-19
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE      97   6e-19
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...    97   6e-19
UniRef50_UPI00015B496D PREDICTED: similar to conserved hypotheti...    97   6e-19
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...    97   7e-19
UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor recep...    97   7e-19
UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=...    97   7e-19
UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeoc...    97   7e-19
UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax...    97   7e-19
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...    97   8e-19
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...    97   8e-19
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...    97   9e-19
UniRef50_UPI00019266B8 PREDICTED: similar to Bam32 n=1 Tax=Hydra...    96   1e-18
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...    96   2e-18
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...    96   2e-18
UniRef50_UPI000194DC0C PREDICTED: similar to nuclear localized f...    96   2e-18
UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus...    96   2e-18
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...    96   2e-18
UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=...    95   3e-18
UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=...    95   3e-18
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...    95   3e-18
UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax...    94   5e-18
UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis R...    94   5e-18
UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE         94   6e-18
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...    94   6e-18
UniRef50_Q9VXH3 Small wing n=17 Tax=Drosophila RepID=Q9VXH3_DROME      94   6e-18
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...    94   6e-18
UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 ...    94   7e-18
UniRef50_Q18865 Putative uncharacterized protein n=6 Tax=Caenorh...    94   9e-18
UniRef50_UPI0000D9EE2E PREDICTED: similar to src homology 2 doma...    93   1e-17
UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 ...    93   1e-17
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...    93   1e-17
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...    93   1e-17
UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax...    93   1e-17
UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeni...    93   1e-17
UniRef50_UPI00016E9A01 UPI00016E9A01 related cluster n=3 Tax=Tet...    93   1e-17
UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistoso...    93   2e-17
UniRef50_A7SCW1 Predicted protein n=1 Tax=Nematostella vectensis...    92   2e-17
UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax...    92   2e-17
UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphod...    92   2e-17
UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia ...    92   2e-17
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...    92   2e-17
UniRef50_A1L2D2 Src homology 2 domain containing transforming pr...    92   2e-17
UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase...    92   2e-17
UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequ...    92   3e-17
UniRef50_C3Y8I0 Putative uncharacterized protein (Fragment) n=1 ...    92   3e-17
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...    92   3e-17
UniRef50_B7Q2R0 Adaptor protein Crk, putative (Fragment) n=1 Tax...    91   4e-17
UniRef50_UPI00016E9A03 UPI00016E9A03 related cluster n=1 Tax=Tak...    91   5e-17
UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tet...    91   5e-17
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...    91   5e-17
UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax...    91   6e-17
UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME         91   6e-17
UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun seq...    91   7e-17
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...    91   7e-17
UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo sal...    91   7e-17
UniRef50_C4Q974 Growth factor receptor-bound protein, putative n...    90   8e-17
UniRef50_UPI0000E460CB PREDICTED: similar to V-crk sarcoma virus...    90   8e-17
UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tet...    90   8e-17
UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...    90   9e-17
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...    90   1e-16
UniRef50_B0R097 Src homology 2 domain containing F (Fragment) n=...    90   1e-16
UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis...    90   1e-16
UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome ...    89   1e-16
UniRef50_P50745 SH2B adapter protein 3 n=2 Tax=Rattus norvegicus...    89   1e-16
UniRef50_UPI0001924162 PREDICTED: similar to SH2-B PH domain con...    89   2e-16
UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi Rep...    89   2e-16

>UniRef50_Q9TYT3 Putative uncharacterized protein n=4 Tax=Caenorhabditis elegans
           RepID=Q9TYT3_CAEEL
          Length = 316

 Score =  455 bits (1170), Expect = e-126,   Method: Composition-based stats.
 Identities = 316/316 (100%), Positives = 316/316 (100%)

Query: 1   MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA 60
           MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA
Sbjct: 1   MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA 60

Query: 61  AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT 120
           AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT
Sbjct: 61  AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT 120

Query: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP 180
           ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP
Sbjct: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP 180

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP 240
           PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP
Sbjct: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP 240

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
           GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS
Sbjct: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300

Query: 301 LNLIRPVPCPGSDDIE 316
           LNLIRPVPCPGSDDIE
Sbjct: 301 LNLIRPVPCPGSDDIE 316


>UniRef50_A8WZ72 C. briggsae CBR-SHC-1 protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8WZ72_CAEBR
          Length = 317

 Score =  370 bits (949), Expect = e-101,   Method: Composition-based stats.
 Identities = 176/320 (55%), Positives = 228/320 (71%), Gaps = 15/320 (4%)

Query: 1   MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA 60
           M+ ++P +A+ELRSSGV+L+A YLGS+PV ES++VMVSEMR QVV ECIQ VAA VG+T 
Sbjct: 1   MVKIDPIYAQELRSSGVTLAAVYLGSIPVQESMSVMVSEMRSQVVGECIQIVAAKVGLTP 60

Query: 61  AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT 120
            R++NP+V+R+IGEVK+ENF VD+NISSKM+K+I+ SRLIQRHP SFFSFG+QGQ+GTDT
Sbjct: 61  ERDVNPIVARIIGEVKQENFNVDLNISSKMVKVIRSSRLIQRHPLSFFSFGSQGQRGTDT 120

Query: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTV--- 177
           E MFGYIAKNK+G DRRCHV+  + V KL+D L  AI VNT DA+A     N        
Sbjct: 121 ENMFGYIAKNKNGEDRRCHVMSSKAVQKLLDTLVAAIQVNTEDAKAKEMAENPQAASTSG 180

Query: 178 --------PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG 229
                   P  P +   +     +V+  R   V E+V  + WYHG++SR+ AQ+L++  G
Sbjct: 181 TSGPSSTDPLRPPKFTCTE----YVALGRITLVYENVKNQPWYHGHISRDIAQSLIRQPG 236

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
           DFLVR SDHT GK+VLSG T   +HKHLILLD  N+VRT ++TF  I+EL+  H+ NG  
Sbjct: 237 DFLVRCSDHTTGKFVLSGMTEHGDHKHLILLDEKNQVRTPEKTFPTITELVRSHMENGQP 296

Query: 290 VRSEGRDRETSLNLIRPVPC 309
           VRS+G   +T+L L   +P 
Sbjct: 297 VRSDGPQNQTALMLENAIPR 316


>UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming protein 1 (SH2 domain
           protein C1) (Src homology 2 domain containing
           transforming protein C1) isoform 4 n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A1414
          Length = 442

 Score =  316 bits (809), Expect = 8e-85,   Method: Composition-based stats.
 Identities = 96/309 (31%), Positives = 149/309 (48%), Gaps = 23/309 (7%)

Query: 10  EELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV--GVTAAREINPV 67
           +++   GVS    Y+G V V++S+  +    R QV  E I  V   V     A R   P 
Sbjct: 146 DKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPC 205

Query: 68  ---VSRVIGE--VKKENFPVDINISSKMIKIIKQ--SRLIQRHPFSFFSFGAQGQKGTDT 120
              +S ++G   +K    P+ + +S+  + ++     ++I  H     SF + G    DT
Sbjct: 206 SRPLSAILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDP--DT 263

Query: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP 180
                Y+AK+     R CH++  E    L   + + I    F+ +      N    V   
Sbjct: 264 AEYVAYVAKDP-VNQRACHIL--ECPEGLAQDVISTIG-QAFELRFKQYLRNPPKLVTPH 319

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP 240
               RS L  Q+  S+C        + G+ W+HG LSR +A+ALL+  GDFLVR+S  TP
Sbjct: 320 DSLARSCLLLQARSSSCMP---GHRLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTP 376

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
           G+YVL+G  +  + KHL+L+D    VRT+D  F ++S LI YHV+N + + S G    + 
Sbjct: 377 GQYVLTGLQS-GQPKHLLLVDPEGVVRTKDHRFESVSHLISYHVDNHLPIISAG----SE 431

Query: 301 LNLIRPVPC 309
           L L +PV  
Sbjct: 432 LCLQQPVER 440


>UniRef50_Q6NPB1 RH57813p n=16 Tax=Neoptera RepID=Q6NPB1_DROME
          Length = 409

 Score =  271 bits (694), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 98/384 (25%), Positives = 153/384 (39%), Gaps = 90/384 (23%)

Query: 10  EELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAA---REINP 66
           + +   GV+ +  Y G V V  S+  +  E R Q+  ECI  V    G+ +A   R  N 
Sbjct: 25  DVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRVCEAAGLKSAGKRRLTNF 84

Query: 67  VVSRVIGEVKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTELMF 124
           +  R    ++     + IN+SS+ + +  ++   +I  H     SF + G    DT    
Sbjct: 85  ISDRP--SMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPRISFASGGD--NDTLDFL 140

Query: 125 GYIAKNKDGTDRRCHVVFIEDVH--KLIDVLTTA----------INVNTFDAQANAS--- 169
            YIAKN+D   R C+V+         LI  +  A          +N  + D   N S   
Sbjct: 141 AYIAKNEDEW-RACYVLECAGGQSEDLIVTIGKAFALRFNALSRLNDPSADCNINQSCKE 199

Query: 170 ----TSNDGFTV-------------------PAP-----------------------PMR 183
                 ND                        AP                       P  
Sbjct: 200 NVKEYYNDLPNKLPPEVPEPQQQQVQQPLHPHAPRVAQLNLKKPRDRLSSNLIDLNSPPP 259

Query: 184 HRSSLHRQSFV-------SNCRAPTVTE-------DVVGKVWYHGNLSREDAQALLKTEG 229
            +++     F        +N   P+V +        +  +VW+H  +SR  ++ LL+ +G
Sbjct: 260 DQTTNKLGHFDPLQATTAANSVLPSVRDVFDGPQCPLTAEVWFHAGISRPISERLLQQDG 319

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
           DFLVR+S    G+YVL+G   +   KHL+L+D    VRT+DR F +IS LI+YH  + + 
Sbjct: 320 DFLVRESQGKRGQYVLTGLEGK-TPKHLLLIDPEGVVRTKDRIFDSISHLINYHWAHALP 378

Query: 290 VRSEGRDRETSLNLIRPVPCPGSD 313
           + SE    ++ L L  P   P  D
Sbjct: 379 IISE----DSELVLRNPARRPQQD 398


>UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2 domain containing)
           transforming protein 1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180D2C5
          Length = 497

 Score =  189 bits (479), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 52/214 (24%), Positives = 84/214 (39%), Gaps = 25/214 (11%)

Query: 12  LRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVT--------AARE 63
           +   GV  S  YLG V V +S+  +  +MR     E I  V A+ G++        + R+
Sbjct: 38  VMGPGVVYSVQYLGCVEVRQSMRTLDFDMRTLATKEAIWRVLASTGMSPLPPAANRSGRK 97

Query: 64  INPV-VSRVIGEVKKENFP---VDINISSKMIKII--KQSRLIQRHPFSFFSFGAQGQKG 117
             P  V+R++GE     F    +++ IS+  + ++     + I  H     SF + G   
Sbjct: 98  KPPKDVTRILGERPNLKFSQSFINLTISTASLTLVVSNTGQFIANHQMQSISFASGGDP- 156

Query: 118 TDTELMFGYIAKNKDGTDRRCHVVFIED--VHKLIDVLTTAINVNTFDAQANASTSNDGF 175
            DT     Y+AK+     R CHV+   D     +I+ +  A     F+ +      N   
Sbjct: 157 -DTIDYVAYVAKDPI-NSRACHVLKCTDGLAQDVINTIGQA-----FELRFKEYLKNPPK 209

Query: 176 TVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGK 209
            V  PP R     H          P    ++ GK
Sbjct: 210 AV-TPPDRTEPLFHDGKSRWGDDEPEYYNEIPGK 242



 Score =  134 bits (337), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 44/111 (39%), Positives = 72/111 (64%), Gaps = 5/111 (4%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
             + T  +  K W+HG+++R++A+ LL  +GDFLVR+S  T G++VLSG   + ++KHL+
Sbjct: 388 PTSATNALQSKPWFHGHVTRKEAEQLLSHDGDFLVRESTTTKGQFVLSG-VQDGQYKHLL 446

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           L+D +  VRT+DR F ++S LI +H +N + + S G    + L L +PV  
Sbjct: 447 LVDPNGVVRTKDRQFDSVSHLISFHRDNTLPIVSSG----SVLLLRQPVTR 493


>UniRef50_A7RR81 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7RR81_NEMVE
          Length = 473

 Score =  179 bits (453), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 49/178 (27%), Positives = 77/178 (43%), Gaps = 17/178 (9%)

Query: 12  LRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINP--VVS 69
           LR  GV  +  Y+G + V +S+  +  E+R QV  E I       G    +   P   VS
Sbjct: 35  LREGGVCYAVKYVGCLSVEKSMRTLPYEVRQQVTREAILRCCEAAGYPLPKRKKPHKNVS 94

Query: 70  RVIGEVKKENF---PVDINISSKMIKII--KQSRLIQRHPFSFFSFGAQGQKGTDTELMF 124
           R++GE    N     V++ IS+  +K++     R I  H     SF + G+K  D   M 
Sbjct: 95  RILGETPNMNHSGTNVNLTISATGMKMVDMNNGRRIANHDMQGISFASGGEK--DCVNMV 152

Query: 125 GYIAKNKDGTDRRCHVVFI--EDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP 180
           GY+AK++    R CHV     E  + +I+ +  A     F+ +      N    +  P
Sbjct: 153 GYVAKDE-VNGRACHVCDCGGELAYDVINTVGQA-----FEIRFKMFLQNPPQAMEVP 204



 Score =  130 bits (328), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 51/161 (31%), Positives = 82/161 (50%), Gaps = 9/161 (5%)

Query: 151 DVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTED----V 206
           D +    N  T  +     T      +      + +   + S   +  AP  +      +
Sbjct: 315 DDIPEYHNPETRFSSPPQPTHAPKNLMDDDIPEYHNPETQFSLPLSVHAPVASTRSSSFM 374

Query: 207 VGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
             K WYHG +SR +A+ LL+ EGDFLVR+S   PG+YVLSG   + + +HL+L+D   +V
Sbjct: 375 RAKDWYHGPISRGEAELLLEDEGDFLVRESKSQPGQYVLSG-IKDKQARHLLLVDPQGQV 433

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           RTRD+ F N+ +LI +H+ N + + S G    + + +  PV
Sbjct: 434 RTRDKVFENVDQLISFHLVNQVPIISAG----SEVTIKHPV 470


>UniRef50_B4IYA5 GH15138 n=5 Tax=Drosophila RepID=B4IYA5_DROGR
          Length = 442

 Score =  174 bits (441), Expect = 4e-42,   Method: Composition-based stats.
 Identities = 43/178 (24%), Positives = 71/178 (39%), Gaps = 13/178 (7%)

Query: 10  EELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAA--REINPV 67
           + +   GV+ +  Y G V V  S+  +  E R  +  ECI  V    G+ +A  R ++  
Sbjct: 27  DIILEKGVTFNVRYTGCVEVKTSMKSLDFETRTLLARECINRVCEAAGLKSASKRRLDKK 86

Query: 68  VSRVIGEVK---KENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTEL 122
           +   I +          + IN+SS+ + +  ++   +I  H     SF + G    DT  
Sbjct: 87  LHNFISDRPSMQHAGTNIIINVSSRALTLSNVETGEVIASHNMPRISFASGGD--NDTLD 144

Query: 123 MFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTS-NDGFTVPA 179
              YIAK +    R C+V+         + L   I    F  + NA +  ND     A
Sbjct: 145 FLAYIAKREGDEWRACYVLECGGGQS--EDLIVTIG-KAFVLRFNALSRQNDHLASAA 199



 Score =  137 bits (344), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 43/111 (38%), Positives = 70/111 (63%), Gaps = 5/111 (4%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
           +  +VW+H  +SR  ++ LL+ +GDFLVR+S    G+YVL+G   +   KHL+L+D    
Sbjct: 328 LTAEVWFHAAISRPISERLLQQDGDFLVRESQGKRGQYVLTGLEGK-APKHLLLIDPEGV 386

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDDIE 316
           VRT+DR F +IS LI+YH  + + + SE    ++ L L  PV  P +++++
Sbjct: 387 VRTKDRIFDSISHLINYHWVHALPIISE----DSELVLRNPVRRPANNNLD 433


>UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein CG3715-PA n=2
           Tax=Apocrita RepID=UPI000051A29D
          Length = 443

 Score =  170 bits (430), Expect = 7e-41,   Method: Composition-based stats.
 Identities = 39/171 (22%), Positives = 71/171 (41%), Gaps = 14/171 (8%)

Query: 16  GVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAA---REINPVVSRVI 72
           G++ +  Y+G + V  S+  +  E R  V  ECI  V    G+ +A   R ++  V R I
Sbjct: 27  GITYTVKYIGCLEVYTSMKSLDFETRSCVAKECINRVCEAAGLKSADKKRRVDRKVLRAI 86

Query: 73  GE---VKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYI 127
            +   ++     +++ ISS  + +  I+   +I +H     SF + G   T+      Y+
Sbjct: 87  ADKPRMEHTGATINLTISSCSLALTNIENGHIIAKHEMPRISFASGGD--TEILDFVAYV 144

Query: 128 AKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVP 178
           AKN     R C+V+       L   + + I    F+ +     +      P
Sbjct: 145 AKNMQEW-RACYVLECGG--GLAQDVISTIG-QAFELRFKEFLTKPASLHP 191



 Score =  140 bits (352), Expect = 7e-32,   Method: Composition-based stats.
 Identities = 47/153 (30%), Positives = 83/153 (54%), Gaps = 6/153 (3%)

Query: 162 FDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP-TVTEDVVGKVWYHGNLSRED 220
            D+   AS  N         +             N  +P +  + +  ++W+HG++SR +
Sbjct: 296 NDSVIAASRENQRDQTSLFDVFDMQPFSSAISDMNKLSPHSQKQQLKQEIWFHGSVSRAE 355

Query: 221 AQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELI 280
           A+++L  +GDFLVR+S  +PG+YVL+G    N  KHL+L+D    VRT+DR F ++S L+
Sbjct: 356 AESMLTRDGDFLVRESQGSPGQYVLTGMN-NNTPKHLLLIDPEGVVRTKDRVFDSVSHLV 414

Query: 281 DYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           ++H +N + + S     ++ L L  P+P   ++
Sbjct: 415 NHHCDNVLPIISA----DSVLVLRYPIPRRTNN 443


>UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2
           domain-containing-transforming protein C3) (Neuronal
           Shc) (N-Shc) (Protein Rai). n=15 Tax=Euteleostomi
           RepID=UPI0000ECC29C
          Length = 582

 Score =  160 bits (405), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 45/215 (20%), Positives = 85/215 (39%), Gaps = 28/215 (13%)

Query: 9   AEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV--GVTAAREINP 66
           +E++   GV+    YLG + V+ S+  +    R Q+  E I  V   V     A ++  P
Sbjct: 146 SEKILGPGVTYIVKYLGCIEVLRSMRSLDFNTRTQITREAISRVCEAVPGAKGAFKKRKP 205

Query: 67  ---VVSRVIGE--VKKENFPVDINISSKMIKII--KQSRLIQRHPFSFFSFGAQGQKGTD 119
              V+S ++G+  ++     + +NIS+  + ++     ++I  H     SF + G    D
Sbjct: 206 PSKVLSSILGKSNLQFAGISIMLNISTTSLNLMTPDMKQIIANHHMQSISFASGGDP--D 263

Query: 120 TELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPA 179
           T     Y+AK+     R CH++  E  + L   + + I    F+ +           +P 
Sbjct: 264 TTDYVAYVAKDP-VNRRACHIL--ECCNGLAQDVISTIG-QAFELRFKQYLQCPSK-MPT 318

Query: 180 PPMRHRSSLHRQSFVSNCRAPTVTEDVVG--KVWY 212
              R +S             P + E+       +Y
Sbjct: 319 FHDRMQS----------FDEPLMEEESAAAEHPYY 343



 Score =  132 bits (333), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 45/102 (44%), Positives = 63/102 (61%), Gaps = 5/102 (4%)

Query: 208 GKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
            K WY G +SR++A+ LLK  GDFLVR+S   PG YVL+G     + KHL+L+D    VR
Sbjct: 484 EKPWYQGEMSRKEAEQLLKKCGDFLVRKSTTNPGSYVLTGM-QNGQAKHLLLVDPEGTVR 542

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           T+DR F +IS LI++H+ N + + S G    + L L +P   
Sbjct: 543 TKDRVFDSISHLINHHLENNLPIVSSG----SKLCLQQPAER 580


>UniRef50_Q3ZAX3 Shc3 protein n=9 Tax=Euteleostomi RepID=Q3ZAX3_MOUSE
          Length = 341

 Score =  157 bits (396), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 46/216 (21%), Positives = 82/216 (37%), Gaps = 24/216 (11%)

Query: 6   PSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV--GVTAARE 63
           P  ++++   GV+    YLG + V+ S+  +    R QV  E I  V   V     A ++
Sbjct: 22  PHTSDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQVTREAISRVCEAVPGAKGALKK 81

Query: 64  INP---VVSRVIGE--VKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQK 116
             P   ++S ++G+  ++     + + IS+  + +      ++I  H     SF + G  
Sbjct: 82  RKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDP 141

Query: 117 GTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFT 176
             DT     Y+AK+     R CH++  E    L   +  +I    F+ +           
Sbjct: 142 --DTTDYVAYVAKDP-VNRRACHIL--ECCDGLAQDVIGSIG-QAFELRFKQYLQCPSK- 194

Query: 177 VPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWY 212
           VPA   R +S L           P          +Y
Sbjct: 195 VPALQDRMQS-LDEPWTEEEGDGP-------DHPYY 222


>UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi RepID=SHC3_HUMAN
          Length = 594

 Score =  156 bits (394), Expect = 9e-37,   Method: Composition-based stats.
 Identities = 44/236 (18%), Positives = 87/236 (36%), Gaps = 30/236 (12%)

Query: 6   PSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV--GVTAARE 63
           P  ++++   GV+    YLG + V+ S+  +    R Q+  E I  V   V     A ++
Sbjct: 142 PHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKK 201

Query: 64  INP---VVSRVIGE--VKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQK 116
             P   ++S ++G+  ++     + + IS+  + +      ++I  H     SF + G  
Sbjct: 202 RKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDP 261

Query: 117 GTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFT 176
             DT     Y+AK+     R CH++  E    L   +  +I    F+ +           
Sbjct: 262 --DTTDYVAYVAKDP-VNRRACHIL--ECCDGLAQDVIGSIG-QAFELRFKQYLQCPTKI 315

Query: 177 VPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFL 232
              P +  R     + +           D      Y+ ++      + +   G FL
Sbjct: 316 ---PALHDRMQSLDEPWTEE------EGDGSDHP-YYNSIP-----SKMPPPGGFL 356



 Score =  139 bits (349), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 47/141 (33%), Positives = 80/141 (56%), Gaps = 7/141 (4%)

Query: 171 SNDGFTVPAPPMRHRSSLHRQSFVSNCRAP--TVTEDVVGKVWYHGNLSREDAQALLKTE 228
            +     P  P+  +++        + RAP   + E++  + WY G +SR++A+ LL+ +
Sbjct: 457 EDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKD 516

Query: 229 GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGM 288
           GDFLVR+S   PG +VL+G     + KHL+L+D    +RT+DR F +IS LI++H+ + +
Sbjct: 517 GDFLVRKSTTNPGSFVLTGMH-NGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSL 575

Query: 289 AVRSEGRDRETSLNLIRPVPC 309
            + S G    + L L +PV  
Sbjct: 576 PIVSAG----SELCLQQPVER 592


>UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7Q1P4_IXOSC
          Length = 461

 Score =  155 bits (392), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 50/213 (23%), Positives = 84/213 (39%), Gaps = 23/213 (10%)

Query: 10  EELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA---AREINP 66
           +E+   GV+    Y+G + V  S+  +  + R  +  ECI  V    G+ A    R+++ 
Sbjct: 13  QEVLGLGVTYRVRYIGCLDVKMSMKCLDFDTRSLIAKECITRVCEAAGLKAVDKKRKVDR 72

Query: 67  VVSRVIGEVKKE---NFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTE 121
            + R++ E          V++ ++S  +K+  ++  + I  H     SF + G    +T 
Sbjct: 73  RLQRMLAERPNMDYAGSNVNLCVTSSSLKLSILETGQAIADHNMPNISFASGGD--AETL 130

Query: 122 LMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPP 181
               Y+AK+  G  R C V+       L   + T I    F+ +           VPAPP
Sbjct: 131 DFVAYVAKDGQG-ARACLVLECGG--GLAQDVITTIG-QAFELRFREFMRG----VPAPP 182

Query: 182 MRHRSSLHRQSFVSNCRA-----PTVTEDVVGK 209
                   R    S  RA     P    D+ GK
Sbjct: 183 PLPSLVPRRCVGSSPLRAGRSDDPEYYNDLPGK 215



 Score =  136 bits (342), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 42/105 (40%), Positives = 69/105 (65%), Gaps = 5/105 (4%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
           +  + W+HG +SR++++  L  +GDFLVR+S   PG++VL+G    +  +HL+L+D    
Sbjct: 361 LEKEAWFHGAISRKESEGRLAEDGDFLVRESQGNPGQFVLTGMQG-SARRHLLLVDPAGV 419

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
           VRT+DRTF ++S L++YH +N + + S     E++L L  PVP P
Sbjct: 420 VRTKDRTFDSVSHLVNYHRDNALPIISA----ESALVLKNPVPRP 460


>UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi RepID=SHC4_HUMAN
          Length = 630

 Score =  155 bits (391), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 41/178 (23%), Positives = 76/178 (42%), Gaps = 15/178 (8%)

Query: 5   EPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV-GVTAA-- 61
           +  F + L   G++    Y+G V V++S+  +   MR QV  E I  +   V G   A  
Sbjct: 178 DRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIK 237

Query: 62  REINPV--VSRVIGE--VKKENFPVDINISSKMIKIIK--QSRLIQRHPFSFFSFGAQGQ 115
           +   PV  +S V+G+  ++     + + IS+  + ++     ++I  H     SF + G 
Sbjct: 238 KRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGD 297

Query: 116 KGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSND 173
              DT     Y+AK+     R CH++  E  + +   + + I    F+ +      N 
Sbjct: 298 P--DTTDYVAYVAKDP-VNQRACHIL--ECHNGMAQDVISTIG-QAFELRFKQYLKNP 349



 Score =  139 bits (350), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 53/193 (27%), Positives = 87/193 (45%), Gaps = 14/193 (7%)

Query: 124 FGYIAKNKDGTDRRCHVVFIEDVHKLIDV---LTTAINVNTFDAQANASTSNDGFTVPA- 179
            G +      + R   ++       L D    + T    +T  +  N    +        
Sbjct: 434 IGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQ--RSAQPLGSPW 491

Query: 180 ---PPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQS 236
                             S+   P + + +  +  YHG LSR+ A++LL  +GDFLVR+S
Sbjct: 492 HCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRES 551

Query: 237 DHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRD 296
             +PG+YVLSG     + KHL+L+D   +VRT+D  F N+  LI YH++N + + S G  
Sbjct: 552 ATSPGQYVLSGLQG-GQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSG-- 608

Query: 297 RETSLNLIRPVPC 309
             + ++L +PV  
Sbjct: 609 --SEVSLKQPVRK 619


>UniRef50_A9V4N6 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V4N6_MONBE
          Length = 363

 Score =  154 bits (390), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 49/202 (24%), Positives = 82/202 (40%), Gaps = 11/202 (5%)

Query: 16  GVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGV--TAAREINPVVSRVIG 73
           G+     YLG +P   S+  M  E R  V  E IQ V+ TVGV     R+  P++ R + 
Sbjct: 34  GIVYPVKYLGKIPFAMSMRTMRFEDRTAVTREAIQLVSETVGVVDPVTRQATPLMKRTLV 93

Query: 74  E---VKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKN 130
           E       N  + I+++   I++I+   +I  H     SF   G +  +T    GYIAK+
Sbjct: 94  EDPVAMNLNVRLKISVTGLTIQVIETGEIIGTHIVPSISFA-TGDR-PNTYERIGYIAKD 151

Query: 131 KDGTDRRCHVVFI-EDVHKLIDVLTTA--INVNTFDAQANASTSNDGFTVPAPPMRHRSS 187
           +   +R CHV       ++++  +  A  +   +F A+              P  R +  
Sbjct: 152 QR-NNRECHVFDCGSRANEIMVTIGQAFELRYKSFLAKGQRQGMQAHAPPVPPMPRAQHM 210

Query: 188 LHRQSFVSNCRAPTVTEDVVGK 209
             +   V   +AP   +     
Sbjct: 211 PAQYDVVGEEQAPIYDQAFDTH 232


>UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi RepID=SHC2_MOUSE
          Length = 573

 Score =  151 bits (382), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 36/179 (20%), Positives = 67/179 (37%), Gaps = 14/179 (7%)

Query: 11  ELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV----GVTAAREINP 66
            +   GVS    Y+G + V+ S+  +    R QV  E I  +   V    G    +  N 
Sbjct: 123 RVLGPGVSYIVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNK 182

Query: 67  VVSRVIG----EVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTEL 122
            ++ ++G         +  V+I++    + +    ++I  H     SF + G   TD   
Sbjct: 183 ALASILGKSNLRFAGMSISVNISVDGLNLSVPATRQIIANHHMQSISFASGGD--TDMTD 240

Query: 123 MFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPP 181
              Y+AK+     R CH++  E    L   + + +    F+ +      +    V  P 
Sbjct: 241 YVAYVAKDPI-NQRACHIL--ECCEGLAQSVISTVG-QAFELRFKQYLHSPPKAVVPPE 295



 Score =  145 bits (366), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 54/143 (37%), Positives = 79/143 (55%), Gaps = 12/143 (8%)

Query: 164 AQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTV--TEDVVGKVWYHGNLSREDA 221
            + +A +   G T  +PP+  +            RAP     E +  + WYHG +SR  A
Sbjct: 434 LKLHACSVAAGITAASPPLEDQWP-----SPPTRRAPIAPTEEQLRQEPWYHGRMSRRAA 488

Query: 222 QALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELID 281
           + LL+ +GDFLVR S   PG+YVL+G  A  + KHL+L+D    VRT+D  F +IS LID
Sbjct: 489 EKLLRADGDFLVRDSVTNPGQYVLTGMHA-GQPKHLLLVDPEGVVRTKDVLFESISHLID 547

Query: 282 YHVNNGMAVRSEGRDRETSLNLI 304
           YH+ NG+ + +     E+ L+L 
Sbjct: 548 YHLKNGLPIVAA----ESELHLR 566


>UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=4 Tax=Endopterygota
           RepID=P18106-3
          Length = 475

 Score =  151 bits (382), Expect = 3e-35,   Method: Composition-based stats.
 Identities = 55/227 (24%), Positives = 94/227 (41%), Gaps = 23/227 (10%)

Query: 89  KMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHK 148
           KMI+ +     +     S  S G+    G  +        ++KD    RC     +   K
Sbjct: 2   KMIEHVNGGSPVANG--SIISNGSNTSNGIQS-NKDSLCRQSKDLNALRCQE---KQKQK 55

Query: 149 LIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVG 208
           L+D++  A+N      +   S  +D  T+    + +  +  +Q  +S  R       +  
Sbjct: 56  LVDMIKCALN--EVGCEELPSGCDDDLTLEQNFIENGYNNEQQISLSTNRP------LYE 107

Query: 209 KVWYHGNLSREDAQALLKTEGDFLVRQS-DHTPGKYVLSGRTAENEHKHLILLDN-HNRV 266
           + W+HG L RE+   LL  +GDFLVR++  +   + VLS     N HKH I+        
Sbjct: 108 EEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCW--NGHKHFIVQTTGEGNF 165

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           R     F++I ELI +  ++ + V       ++   L RPV     +
Sbjct: 166 RFEGPPFASIQELIMHQYHSELPVT-----VKSGAILRRPVCRERWE 207


>UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda RepID=SHC2_HUMAN
          Length = 582

 Score =  149 bits (376), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 37/186 (19%), Positives = 69/186 (37%), Gaps = 14/186 (7%)

Query: 11  ELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV----GVTAAREINP 66
            +   GVS    Y+G + V+ S+  +    R QV  E I  +   V    G    +  N 
Sbjct: 145 RVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNK 204

Query: 67  VVSRVIGE--VKKENFPVDINISS--KMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTEL 122
            ++ V+G+  ++     + I+IS+    + +    ++I  H     SF + G   TD   
Sbjct: 205 ALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGD--TDMTD 262

Query: 123 MFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPM 182
              Y+AK+     R CH++  E    L   + + +    F+ +      +       P  
Sbjct: 263 YVAYVAKDPI-NQRACHIL--ECCEGLAQSIISTVG-QAFELRFKQYLHSPPKVALPPER 318

Query: 183 RHRSSL 188
                 
Sbjct: 319 LAGPEE 324



 Score =  140 bits (353), Expect = 5e-32,   Method: Composition-based stats.
 Identities = 50/143 (34%), Positives = 75/143 (52%), Gaps = 12/143 (8%)

Query: 164 AQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTV--TEDVVGKVWYHGNLSREDA 221
            + +  +   G T    P+  +            RAP     E +  + WYHG +SR  A
Sbjct: 443 LKLHECSVAAGVTAAPLPLEDQWP-----SPPTRRAPVAPTEEQLRQEPWYHGRMSRRAA 497

Query: 222 QALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELID 281
           + +L+ +GDFLVR S   PG+YVL+G  A  + KHL+L+D    VRT+D  F +IS LID
Sbjct: 498 ERMLRADGDFLVRDSVTNPGQYVLTGMHA-GQPKHLLLVDPEGVVRTKDVLFESISHLID 556

Query: 282 YHVNNGMAVRSEGRDRETSLNLI 304
           +H+ NG  + +     E+ L+L 
Sbjct: 557 HHLQNGQPIVAA----ESELHLR 575


>UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Tax=Eutheria
           RepID=Q6S5L8-2
          Length = 387

 Score =  140 bits (352), Expect = 8e-32,   Method: Composition-based stats.
 Identities = 53/193 (27%), Positives = 87/193 (45%), Gaps = 14/193 (7%)

Query: 124 FGYIAKNKDGTDRRCHVVFIEDVHKLIDV---LTTAINVNTFDAQANASTSNDGFTVPA- 179
            G +      + R   ++       L D    + T    +T  +  N    +        
Sbjct: 191 IGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQ--RSAQPLGSPW 248

Query: 180 ---PPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQS 236
                             S+   P + + +  +  YHG LSR+ A++LL  +GDFLVR+S
Sbjct: 249 HCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRES 308

Query: 237 DHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRD 296
             +PG+YVLSG     + KHL+L+D   +VRT+D  F N+  LI YH++N + + S G  
Sbjct: 309 ATSPGQYVLSGLQG-GQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSG-- 365

Query: 297 RETSLNLIRPVPC 309
             + ++L +PV  
Sbjct: 366 --SEVSLKQPVRK 376



 Score = 74.3 bits (181), Expect = 5e-12,   Method: Composition-based stats.
 Identities = 17/76 (22%), Positives = 29/76 (38%), Gaps = 6/76 (7%)

Query: 98  RLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAI 157
            +I  H     SF + G    DT     Y+AK+     R CH++  E  + +   + + I
Sbjct: 37  HIIANHHMQSISFASGGDP--DTTDYVAYVAKDP-VNQRACHIL--ECHNGMAQDVISTI 91

Query: 158 NVNTFDAQANASTSND 173
               F+ +      N 
Sbjct: 92  G-QAFELRFKQYLKNP 106


>UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069FB4F
          Length = 393

 Score =  137 bits (344), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 35/162 (21%), Positives = 67/162 (41%), Gaps = 15/162 (9%)

Query: 21  ATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV--GVTAAREINPVV---SRVIGE- 74
             Y+G + V++S+  +    R QV  E I  +   V     A ++  P V   S ++G+ 
Sbjct: 3   LQYMGCIEVLQSMRSLDFGTRTQVTREAISRLCEAVPGAKGATKKRKPPVKFLSSILGKS 62

Query: 75  -VKKENFPVDINISSKMIKIIK--QSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNK 131
            ++     V ++IS+  + +      +++  H     SF + G    DT     Y+AK+ 
Sbjct: 63  NLQFSGMNVQLSISTNSLILTNSDTQQVVANHHMQSISFASGGDP--DTTDYVAYVAKDP 120

Query: 132 DGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSND 173
               R CH++  E  + L   +  AI    F+ +      + 
Sbjct: 121 -VNQRACHIM--ECTNNLAQDVINAIG-QAFELRFKQFLKSP 158



 Score =  127 bits (320), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 41/116 (35%), Positives = 67/116 (57%), Gaps = 6/116 (5%)

Query: 194 VSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENE 253
           +   + P  +  +  + WYHG ++R+ A++LL  +GDFL+R+S  +  +YVLSG      
Sbjct: 282 IQEPKLPLYSS-LQHEEWYHGKMNRKVAESLLVNDGDFLIRESTTSACQYVLSGLQG-GH 339

Query: 254 HKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            KHL+L+D   +VRT+D  F ++  LI YH+ N + + S G    + L L +PV  
Sbjct: 340 PKHLLLVDPDGKVRTKDHVFESVIHLISYHMENELPIISSG----SELYLRKPVRK 391


>UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=1 Tax=Schistosoma
           mansoni RepID=C4QLR4_SCHMA
          Length = 409

 Score =  136 bits (342), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 53/136 (38%), Positives = 80/136 (58%), Gaps = 10/136 (7%)

Query: 177 VPAPPMRHRSSLHRQSFVSNCRAPT-----VTEDVVGKVWYHGNLSREDAQALLKTEGDF 231
           +   P R  + +     +SN +AP         + VG+ WY G +SR  A+ LL+ +GDF
Sbjct: 271 LSQQPSRKINKVAGVKSISNIKAPVGLPNFEHLEPVGEPWYVGKMSRSQAENLLRYDGDF 330

Query: 232 LVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
           LVR S   PG++VLSG   + +++HL+L D + +VRT++R F +I  LIDYHV NG  +R
Sbjct: 331 LVRASIQQPGQFVLSGL-QDGKYRHLLLADPNGKVRTKERVFDSIQHLIDYHVQNGAPIR 389

Query: 292 SEGRDRETSLNLIRPV 307
           S     ++ + LI PV
Sbjct: 390 S----LDSEIRLIFPV 401



 Score = 98.2 bits (243), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 37/155 (23%), Positives = 67/155 (43%), Gaps = 12/155 (7%)

Query: 14  SSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAA--REINPVVSRV 71
            +GV+    Y+G++PV+ SI  +   +R ++    I+ V   VG+     R  +  + + 
Sbjct: 24  DAGVTFELQYVGAIPVLTSIKSVNINIRTRICRASIRRVCEDVGLKLPSNRSADKSIEQF 83

Query: 72  IG---EVKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGY 126
           IG   ++      V + I+S+ + +  I    L+ +H     SF + G    DT     Y
Sbjct: 84  IGPSTDMTWAIVNVYLTITSQTLTVETIDNGVLLFQHNLFLVSFASAGD--ADTPDFICY 141

Query: 127 IAKNKDGTDRRCHVVFIED--VHKLIDVLTTAINV 159
           +AK    T R C+V    D     +I  +  A  +
Sbjct: 142 VAKTDQDT-RMCYVFECSDGLAQDVIITIGQAFQL 175


>UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E4625F
          Length = 520

 Score =  135 bits (340), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 47/141 (33%), Positives = 73/141 (51%), Gaps = 8/141 (5%)

Query: 168 ASTSNDGFTV-PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK 226
           A   N      P+ P              +   P  T  +  + W+HG +SR++ + LL 
Sbjct: 381 AQPFNPEAAKQPSNPSAGGGGGASGLHPHDMAPP--TNPLYNEEWFHGPMSRKEGEPLLS 438

Query: 227 TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNN 286
            +GDFLVR+S     +YVLSG       KHL+L+D   +VRT+D+ F ++S LI+YH NN
Sbjct: 439 NDGDFLVRESTTAKDQYVLSGM-QNGTPKHLLLVDPQGKVRTKDKEFDSVSHLINYHRNN 497

Query: 287 GMAVRSEGRDRETSLNLIRPV 307
            + + S G    ++++L  PV
Sbjct: 498 RLPIISAG----SAVHLKTPV 514



 Score = 68.6 bits (166), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 31/175 (17%), Positives = 52/175 (29%), Gaps = 45/175 (25%)

Query: 57  GVTAAREINPVVSRVIGEVKKE---NFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFG 111
           GV      +  + ++IGE          V++ IS+  I I   +  + I  H     SF 
Sbjct: 52  GVCYGVRASKTICKIIGENPNILFGGANVNLTISTASINIRIKETGKPIANHQMQGISFA 111

Query: 112 AQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTS 171
           + G   T                   CHV+  E +  L   + T +    F+ +      
Sbjct: 112 SGGDAVT-------------------CHVL--ECLAGLAQDVITTVG-QAFEIRFKDYLR 149

Query: 172 ND----------------GFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKV 210
           N                 G + P  P    ++     F SN   P+ +       
Sbjct: 150 NPPQRHQPYTELLGQQGSGGSSPVGPPPGYTANPPPYFDSN--HPSNSSQASSNP 202


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score =  134 bits (336), Expect = 6e-30,   Method: Composition-based stats.
 Identities = 48/258 (18%), Positives = 101/258 (39%), Gaps = 38/258 (14%)

Query: 81  PVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT----ELMFGYIAKNKDGTDR 136
            + + + +   ++++  +++     +      + ++ ++T      +   +++ +   + 
Sbjct: 304 SLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEEL 363

Query: 137 RCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSN 196
           +  V  +          +    +     Q N               R  +S+ R+  +S 
Sbjct: 364 KQSVQQLRCTEAK---FSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSK 420

Query: 197 C-----------RAP--------------TVTEDVVGKVWYHGNLSREDAQALLKTEGDF 231
                       R+P                 + +  + WYHG + R +AQ LLK +GDF
Sbjct: 421 FESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDF 480

Query: 232 LVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
           LVR+S   PG+YVLS  + + + +H I+    N  R     FSNI +LID+H      + 
Sbjct: 481 LVRESHGKPGEYVLSVYS-DGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVIT 539

Query: 292 SEGRDRETSLNLIRPVPC 309
                 ++ + L+ P+P 
Sbjct: 540 K-----KSGVVLLNPIPK 552


>UniRef50_UPI0001A5EB2D PREDICTED: hypothetical protein XP_002347924 n=1 Tax=Homo sapiens
           RepID=UPI0001A5EB2D
          Length = 475

 Score =  133 bits (334), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 50/143 (34%), Positives = 75/143 (52%), Gaps = 12/143 (8%)

Query: 164 AQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTV--TEDVVGKVWYHGNLSREDA 221
            + +  +   G T    P+  +            RAP     E +  + WYHG +SR  A
Sbjct: 336 LKLHECSVAAGVTAAPLPLEDQWP-----SPPTRRAPVAPTEEQLRQEPWYHGRMSRRAA 390

Query: 222 QALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELID 281
           + +L+ +GDFLVR S   PG+YVL+G  A  + KHL+L+D    VRT+D  F +IS LID
Sbjct: 391 ERMLRADGDFLVRDSVTNPGQYVLTGMHA-GQPKHLLLVDPEGVVRTKDVLFESISHLID 449

Query: 282 YHVNNGMAVRSEGRDRETSLNLI 304
           +H+ NG  + +     E+ L+L 
Sbjct: 450 HHLQNGQPIVAA----ESELHLR 468



 Score = 46.6 bits (109), Expect = 0.001,   Method: Composition-based stats.
 Identities = 7/29 (24%), Positives = 13/29 (44%)

Query: 23  YLGSVPVVESINVMVSEMRVQVVSECIQH 51
           Y+G + V+ S+  +    R QV  +    
Sbjct: 247 YMGCIEVLRSMRSLDFNTRTQVTRDACSL 275


>UniRef50_B3RQY3 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens
           RepID=B3RQY3_TRIAD
          Length = 654

 Score =  130 bits (327), Expect = 7e-29,   Method: Composition-based stats.
 Identities = 50/176 (28%), Positives = 77/176 (43%), Gaps = 26/176 (14%)

Query: 105 FSFFSFGAQGQ--KGTDTELMFG---YIAKNKDGTDRRCHVV----------FIEDVHKL 149
           FS F  G  GQ  K   TE++      ++++   T  RCH            F+  + K 
Sbjct: 374 FSVFRVGKYGQQLKTNYTEMIQSSPEVMSQDFASTRSRCHTTSELPRSRSLSFLRGLSKR 433

Query: 150 IDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGK 209
            D + T     T  + AN S    G  + AP  R R+   R  F  + +  +V +    +
Sbjct: 434 KDTVAT-----TPSSPANDSPVLSGPLLHAPEPRARTGTMR--FTRDKKGISVKDLSYDQ 486

Query: 210 VWYHGNLSREDAQALLK----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
            W+H ++SR  A  +L     ++G FL+R+S  TPG  VLS    +  H   I+LD
Sbjct: 487 PWFHTSISRIQAVDILTDKGTSDGLFLIRESTSTPGSLVLSLCHKKKVHHIQIVLD 542


>UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein, partial n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E479E4
          Length = 926

 Score =  129 bits (323), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 45/170 (26%), Positives = 70/170 (41%), Gaps = 30/170 (17%)

Query: 160 NTFDAQANA-----STSNDGFTVPAP-PMRHRSSLH-------RQSFVSNCRAPTVTEDV 206
            T  + +       S   D F+ P P P+R + SL        R+      + P  +EDV
Sbjct: 64  QTPGSPSRPHFRYSSIPEDHFSKPPPSPIRTKMSLQDMTPEDLRKLLEEEFKLP--SEDV 121

Query: 207 VGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD----- 261
               W+HG +SRE A+ L++  GDFLVR S   PG +VL+ R  +    H ++       
Sbjct: 122 RSHAWFHGGISREKAEKLIRENGDFLVRDSISKPGNFVLTVRW-KGVSMHFVVNKVVLKA 180

Query: 262 ----NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                  + +     F  I  LI ++V N   V      + +   +  PV
Sbjct: 181 HSPYASVQYQFEKECFDAIPSLIKFYVGNCRPVS-----QASGAVIQHPV 225


>UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76978_9METZ
          Length = 879

 Score =  126 bits (317), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 38/112 (33%), Positives = 52/112 (46%), Gaps = 8/112 (7%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
            P     V  + WYHG +SR++A  LLK  GDFLVR S      Y L+ +      KH I
Sbjct: 505 TPEAHAGVEEEPWYHGEISRQEATGLLKKMGDFLVRYSADKE-HYTLTVKMEG--IKHFI 561

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
           +  N    R     + +I  LID+H  N + V      R++   L +PV  P
Sbjct: 562 IQHNEEGFRFEGDPYPSIPMLIDHHFKNRLPVT-----RKSQAILRQPVKKP 608


>UniRef50_UPI00019269FE PREDICTED: similar to protein tyrosine phosphatase, non-receptor
           type 11 n=1 Tax=Hydra magnipapillata RepID=UPI00019269FE
          Length = 544

 Score =  125 bits (313), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 37/162 (22%), Positives = 74/162 (45%), Gaps = 19/162 (11%)

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVG----------KV 210
           T D ++     NDGF      + +      +    N ++  +TE ++           + 
Sbjct: 64  TNDGESFGLYENDGFASVPDLIEYYQHNPSKFLDQNNKSVELTEPLIDDSENDPGLSQEK 123

Query: 211 WYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH--NR 265
           W+ G + R +A+ +LK     G +LVR+S   PG +VLS R   +  + L++  +   + 
Sbjct: 124 WFFGEIGRGEAELILKQRGEHGSYLVRESRTQPGNFVLSVRHHNSVIEFLLIYSDGAFDI 183

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             T+   F  ++ LI+Y + N +      +D + +++LI P+
Sbjct: 184 ANTKRLKFPTMTHLINYFITNPLI----HKDSDQAIHLIEPL 221



 Score = 84.0 bits (206), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 28/108 (25%), Positives = 49/108 (45%), Gaps = 7/108 (6%)

Query: 211 W-YHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           W +  NL+  +A++LLK     G +L R+S  +PG Y LS R  +      I  D  +  
Sbjct: 12  WGFFANLTVAEAESLLKEKGNHGSYLCRRSTSSPGSYTLSVRRQKEVWNFKITNDGESFG 71

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDD 314
              +  F+++ +LI+Y+ +N             S+ L  P+     +D
Sbjct: 72  LYENDGFASVPDLIEYYQHNP---SKFLDQNNKSVELTEPLIDDSEND 116


>UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=Neoptera
           RepID=Q17DJ2_AEDAE
          Length = 564

 Score =  125 bits (313), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 46/170 (27%), Positives = 76/170 (44%), Gaps = 19/170 (11%)

Query: 153 LTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNC--------RAPTVTE 204
           L  ++  +  +   N S  N   T PAP +  R    R S  SN         +A  V  
Sbjct: 349 LANSLVNDVNNLSLNQSALNAVPTKPAPELPPRREEGRISSSSNFELTEGDLEQAHEVDT 408

Query: 205 DV----VGKVWYHGNLSREDAQAL-----LKTEGDFLVRQSDHTPGKYVLSGRTAENEHK 255
           D+        W+HG L+R +A  L     L + G FLVRQS+   G++VL+    + + K
Sbjct: 409 DLTAMMREYPWFHGTLARSEAAQLVLHNGLSSHGVFLVRQSETRKGEFVLTF-NFQGKAK 467

Query: 256 HLILLDNH-NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
           HL +  N   + R +   F +I+E++++   + + + S G    T  N +
Sbjct: 468 HLRMTLNDLGQCRVQHLWFPSITEMLEHFRQHPIPLESGGTADVTLTNFV 517


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score =  124 bits (312), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 36/140 (25%), Positives = 64/140 (45%), Gaps = 19/140 (13%)

Query: 182 MRHRSSLHRQS-FVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSD 237
           M H   L  ++  V   + P    D   + W+HG+LS ++A+ LL      G FLVR+S 
Sbjct: 82  MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQ 141

Query: 238 HTPGKYVLSGRTAEN---------EHKHLILLDNHNRVRT-RDRTFSNISELIDYHVNNG 287
             PG +VLS RT ++         +  H+++     +        F ++++L++++  N 
Sbjct: 142 SHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNP 201

Query: 288 MAVRSEGRDRETSLNLIRPV 307
           M          T L L +P+
Sbjct: 202 MV-----ETLGTVLQLKQPL 216



 Score = 97.8 bits (242), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 12/115 (10%)

Query: 206 VVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +  + W+H N++  +A+ LL T   +G FL R S   PG + LS R       H+ + + 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVR-RNGAVTHIKIQNT 59

Query: 263 HNRVR-TRDRTFSNISELIDYHV-NNGMAVRSEGRDRETSLNLIRPVPC--PGSD 313
            +         F+ ++EL+ Y++ ++G      G      + L  P+ C  P S+
Sbjct: 60  GDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNG----DVIELKYPLNCADPTSE 110


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score =  124 bits (311), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 36/141 (25%), Positives = 63/141 (44%), Gaps = 20/141 (14%)

Query: 182 MRHRSSLHRQS-FVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSD 237
           M H   L  ++  V   + P    D   + W+HG+LS  +A+ LL      G FLVR+S 
Sbjct: 82  MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGREAEKLLTEKGKNGSFLVRESQ 141

Query: 238 HTPGKYVLSGRTAEN---------EHKHLIL--LDNHNRVRTRDRTFSNISELIDYHVNN 286
             PG +VLS RT ++         +  H+++    +          F ++++L++++  N
Sbjct: 142 SHPGDFVLSVRTGDDKTDSSDSKPKVTHVMIRCQHDLKYDVGGGEKFDSLTDLVEHYKKN 201

Query: 287 GMAVRSEGRDRETSLNLIRPV 307
            M          T L L +P+
Sbjct: 202 PMV-----ETLGTVLQLKQPL 217



 Score = 98.2 bits (243), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 12/115 (10%)

Query: 206 VVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +  + W+H N++  +A+ LL T   +G FL R S   PG + LS R       H+ + + 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVR-RNGAVTHIKIQNT 59

Query: 263 HNRVR-TRDRTFSNISELIDYHV-NNGMAVRSEGRDRETSLNLIRPVPC--PGSD 313
            +         F+ ++EL+ Y++ ++G      G      + L  P+ C  P S+
Sbjct: 60  GDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNG----DVIELKYPLNCADPTSE 110


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score =  124 bits (310), Expect = 6e-27,   Method: Composition-based stats.
 Identities = 42/161 (26%), Positives = 64/161 (39%), Gaps = 23/161 (14%)

Query: 153 LTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWY 212
           L T+ ++   D +      +D F     P    + L  ++  +N  AP   E      WY
Sbjct: 21  LGTSADMQNSD-EFQDLPVHDDF----DPFESYTELPEETVDANLTAPPENE------WY 69

Query: 213 HGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTR 269
           HG L R+ A+  L      G +LVR+S+  PG YVLS    +    H  +          
Sbjct: 70  HGCLDRQSAELRLNAADKPGSYLVRESERKPGSYVLSYL-GQRGINHFRVTAVCGDFYVG 128

Query: 270 DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
            R F  + ELI Y+ +    +++E         L  P P P
Sbjct: 129 GRQFQTLPELIGYYTHISNILKNE--------RLQYPAPPP 161



 Score = 98.2 bits (243), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 31/107 (28%), Positives = 50/107 (46%), Gaps = 6/107 (5%)

Query: 184 HRSSLHRQSFVSNCRAPTVTE--DVVGKVWYHGNLSREDAQALLKTEGD---FLVRQSDH 238
            + S      V +   P   E     GKVW+HGN+S+E+A   L  +GD   FL+R SD 
Sbjct: 208 SQRSGESGIIVQDLVKPVEGEIDPNEGKVWFHGNVSKEEAAETLWKDGDIGGFLIRNSDK 267

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVN 285
            PG Y LS R   N  +   +     +     R ++++  ++D++  
Sbjct: 268 NPGDYSLSFR-GPNTIQRFRIQKQQRQYVMGGRYYNSLDAIVDHYKK 313


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score =  122 bits (307), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 35/129 (27%), Positives = 58/129 (44%), Gaps = 8/129 (6%)

Query: 182 MRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDH 238
           M +     +       + P +  +   + W+HGNLS ++A+ L+      G FLVR+S  
Sbjct: 82  MENGELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILERGKNGSFLVRESQS 141

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
            PG +VLS RT +     +I   +         +F  +SELID++  N M          
Sbjct: 142 KPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMV-----ETCG 196

Query: 299 TSLNLIRPV 307
           T ++L +P 
Sbjct: 197 TVVHLRQPF 205



 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 30/108 (27%), Positives = 53/108 (49%), Gaps = 9/108 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +  + W+H  +S  +A+ LL+    +G FL R S   PG + LS R   NE  H+ + +N
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRG-NEVTHIKIQNN 59

Query: 263 HNRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            +         F+ + EL+ Y++ NG      G+    ++ L +P+ C
Sbjct: 60  GDFFDLYGGEKFATLPELVQYYMENGELKEKNGQ----AIELKQPLIC 103


>UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, partial n=1 Tax=Tribolium
           castaneum RepID=UPI000175898D
          Length = 876

 Score =  122 bits (307), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 36/174 (20%), Positives = 69/174 (39%), Gaps = 22/174 (12%)

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
           N+++      + + N+    P       S   +++          + D+    WYHG + 
Sbjct: 125 NLSSVYEPVQSKSLNNLIMEPTADPSMNSLELKKALEWEL--SLDSRDLRSHAWYHGAIP 182

Query: 218 REDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL---------LDNHNRVRT 268
           R  A+ +++ EG FLVR     PG YVL+ RT + +  H ++         +  H + + 
Sbjct: 183 RSRAEDIVREEGGFLVRDCTSQPGNYVLTCRT-KTQPLHFVINKIILQPDTVYEHVQFQF 241

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRE----------TSLNLIRPVPCPGS 312
            +  F  + +LI ++V +G  + +    R           +      P P P S
Sbjct: 242 EEDAFDTVPDLITFYVGSGKPITAASGARIQFPKNRMYPLSFYAAKYPTPLPQS 295


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score =  122 bits (306), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 41/133 (30%), Positives = 65/133 (48%), Gaps = 10/133 (7%)

Query: 178 PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVR 234
           P  P    SSL+    +     P        K WYHG LSR + + LL     +G++L+R
Sbjct: 249 PTKPKHSISSLNTNPPIVKDETPDCI--FRDKDWYHGTLSRSECEFLLNEHAKDGEYLIR 306

Query: 235 QSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
            S+  PG + LS + A N  KH  +L  +N+     R+FSNI EL+ ++ N  +     G
Sbjct: 307 NSESKPGDFSLSMK-APNRIKHFKILYGNNQYVIGQRSFSNIDELLSHYKNYPIYTTENG 365

Query: 295 RDRETSLNLIRPV 307
           +     ++L+ P+
Sbjct: 366 Q----KMHLLYPL 374


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score =  121 bits (304), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 32/134 (23%), Positives = 62/134 (46%), Gaps = 14/134 (10%)

Query: 176 TVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD---FL 232
            VP  P+             N   P+ +     + W+HG ++R+D++ +L   G+   FL
Sbjct: 263 AVPPKPIEMHDE-------DNSFTPSSSVGFYDRDWFHGRITRQDSEKILGCPGESGLFL 315

Query: 233 VRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRS 292
           +R+S+  PG + +S + A    KH  +  +  +     R F ++ +L+D++  + +    
Sbjct: 316 IRESETMPGDFAVSVK-APERVKHFKVTRSDKKFCIGQRKFESLDDLVDHYKRSPIFSSD 374

Query: 293 EGRDRETSLNLIRP 306
           +G   E  L L RP
Sbjct: 375 DG---ELKLYLTRP 385


>UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID=Q7PSB5_ANOGA
          Length = 940

 Score =  120 bits (302), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 33/167 (19%), Positives = 67/167 (40%), Gaps = 13/167 (7%)

Query: 151 DVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKV 210
             +    N  T +       +        P   + +   +++          + D+    
Sbjct: 182 QSVVCTDNKMTNNIGVVFGGAKCSLQETTPDGGNEAVALKKALEWEL--SLDSRDLRSHA 239

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL---------LD 261
           WYHG + R+ A+ +++ EGDFLVR     PG YVL+ RT +    H ++         + 
Sbjct: 240 WYHGPIPRQRAEEIVQKEGDFLVRDCVSQPGNYVLTCRT-KGPTLHFVINKLLLQPETVY 298

Query: 262 NHNRVRTRDRTFSNISELIDYHVNNGMAVR-SEGRDRETSLNLIRPV 307
              + +  D  +  + +LI ++V +G ++  + G   +   N   P+
Sbjct: 299 ERVQYQFEDDAYDTVPDLITFYVGSGKSISVASGARIQFPCNRTYPL 345


>UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group RepID=Q9VMJ4_DROME
          Length = 944

 Score =  119 bits (299), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 35/162 (21%), Positives = 68/162 (41%), Gaps = 12/162 (7%)

Query: 156 AINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGN 215
           AI  +  +   +++ +    T    P   + ++  +  +          ++    WYHG 
Sbjct: 186 AIEDSRMEGYGSSNATTPLATAQPSPSEQQEAIALKKAL-EWELSLDARELRSHAWYHGA 244

Query: 216 LSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL---------LDNHNRV 266
           L R+ A+ +++ EGDFLVR     P  YVLS R+ +    H +L         +    + 
Sbjct: 245 LPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRS-KAAVLHFVLNKLVLQPETVYERVQY 303

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRS-EGRDRETSLNLIRPV 307
           +  +  F  + +LI ++V +G  + S  G   +   N   P+
Sbjct: 304 QFEEDAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPL 345


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score =  119 bits (298), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 35/140 (25%), Positives = 63/140 (45%), Gaps = 12/140 (8%)

Query: 177 VPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLV 233
           +  P +  +     +S V+    P     +V K WY+G+++R     LL     +GDFL+
Sbjct: 282 LTQPFLDRKQEPMERSQVAMGDKPH----LVDKPWYYGSITRYMCDNLLNQRGHDGDFLI 337

Query: 234 RQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           R S+   G Y +S + A   +KH  +           R F  + +L+D++    +    +
Sbjct: 338 RDSETNVGDYSVSLK-APGRNKHFRVHVEGALYCIGQRKFHTLDQLVDHYQRAPIYTNKQ 396

Query: 294 GRDRETSLNLIRPVPCPGSD 313
           G      L L+RP+P P ++
Sbjct: 397 GE----KLYLVRPLPKPTTN 412


>UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7P6T2_IXOSC
          Length = 702

 Score =  119 bits (298), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 24/108 (22%), Positives = 46/108 (42%), Gaps = 10/108 (9%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL- 259
             + D+    WYHG + R+ A+ L+  +G FLVR     PG YVL+    +    H ++ 
Sbjct: 18  LDSRDMRSHAWYHGTIPRQRAEELMTADGGFLVRDCVSRPGDYVLTCCW-KGAPLHFVIN 76

Query: 260 --------LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
                   +    + +  D  F  + +L+ ++V N   + +      +
Sbjct: 77  KVVLQPYTVYERIQYQFEDDCFDTVPDLVTFYVGNKRPISAASGAVVS 124


>UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS
          Length = 965

 Score =  119 bits (298), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 35/163 (21%), Positives = 66/163 (40%), Gaps = 11/163 (6%)

Query: 155 TAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHG 214
            A N+++     + S ++    V +P    +                   ++    WYHG
Sbjct: 185 AAANIDSEMEHNSGSNASTPIAVNSPNPNEQQEAIALKKALEWELSLDARELRSHAWYHG 244

Query: 215 NLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL---------LDNHNR 265
            L R+ A+ +++ EGDFLVR     P  YVLS R+ +    H +L         +    +
Sbjct: 245 PLPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRS-KLAVLHFVLNKLVLQPETVYERVQ 303

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVR-SEGRDRETSLNLIRPV 307
            +  +  F  + +LI ++V +G  +  + G   +   N   P+
Sbjct: 304 YQFEEDAFDTVPDLITFYVGSGKPISAASGALIQYPCNRRYPL 346


>UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putative n=1
           Tax=Schistosoma mansoni RepID=C5J914_SCHMA
          Length = 708

 Score =  119 bits (297), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 37/131 (28%), Positives = 63/131 (48%), Gaps = 10/131 (7%)

Query: 182 MRHRSSLHRQSFV-SNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD---FLVRQSD 237
           M +   L  ++      + P ++ED   + W+HG ++ ++A+ +L   G    FLVR+S 
Sbjct: 84  MENEGQLREKNGDLIELKYPLISEDPTTERWFHGKITGKEAEKMLLERGKPDCFLVRESV 143

Query: 238 HTPGKYVLSGRTAENEHKHLILLDNHNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRD 296
           H PG YVLS  T E     +I    +          FS++ ELID++ N  M  ++ G  
Sbjct: 144 HRPGSYVLSVLTGEQVAHIMIHGKPNGMYDVGGGHQFSSLKELIDFYTNTPMVEKNGG-- 201

Query: 297 RETSLNLIRPV 307
               ++L +P 
Sbjct: 202 ---LVSLKQPF 209



 Score = 89.4 bits (220), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 6/106 (5%)

Query: 207 VGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +G  W+H NL+  +A+ LL      G FL R S  TPG + LS R  +      I     
Sbjct: 4   IGGRWFHHNLTGLEAEKLLTLKGVSGSFLARPSHSTPGSFTLSVRRGDEVTHIRIQNTEE 63

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                    F+ +SEL+ Y++ N   +R         + L  P+  
Sbjct: 64  FLDLYGGEKFATLSELVTYYMENEGQLR---EKNGDLIELKYPLIS 106


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  118 bits (295), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 31/124 (25%), Positives = 58/124 (46%), Gaps = 15/124 (12%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSG---RTAENE 253
           +  +  D+  + W+HGN+ R +A+ LL+    G FL+R+S+   G Y L+    +    +
Sbjct: 56  SHLIQLDLTNEPWFHGNIGRIEAENLLQYSEPGTFLIRESETIKGSYTLTMIQIKDGTKQ 115

Query: 254 HKHLIL-LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGS 312
             H  +  D+     T  R F  + +LI +++ N   +         + NL+ P P P  
Sbjct: 116 ISHFRINYDDGKYFITSARRFLGLHQLIQHYMQNSDGL---------ACNLVYPQPKPSI 166

Query: 313 DDIE 316
           + +E
Sbjct: 167 EYME 170


>UniRef50_UPI00006A1C31 UPI00006A1C31 related cluster n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI00006A1C31
          Length = 419

 Score =  117 bits (294), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 38/116 (32%), Positives = 53/116 (45%), Gaps = 14/116 (12%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
             +ED+    WYHG L R+DA+ LL + GDFL+R S  +PG YVLS   A  +  H  ++
Sbjct: 5   LSSEDLRSHAWYHGPLPRQDAERLLVSNGDFLIRDSISSPGDYVLSCFCAGGQPLHFKII 64

Query: 261 DNHNR---------VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
               R          +     F NI  L+  +V +   V        T   +IRPV
Sbjct: 65  AVALRPRRGIARTLYQLEQDQFDNIPALVRSYVGDRRKVSES-----TGAVIIRPV 115


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score =  117 bits (294), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 26/127 (20%), Positives = 55/127 (43%), Gaps = 6/127 (4%)

Query: 188 LHRQSFVSNCRAPTV-TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLS 246
              +      ++P   ++ +  + W+HG + R ++  LL+ +GDFL+R+S+++ G +VLS
Sbjct: 446 NKLKFKDDGVKSPMDQSKTIKEQTWFHGTIPRTESLRLLQQDGDFLLRESNNSLGDFVLS 505

Query: 247 GRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
            +         + + ++   R     F  +  LI +H      V        T+  L+ P
Sbjct: 506 AKADGQVRHFKVQVTDNGMYRFEADQFPTVLNLISHHYQKREPVTK-----RTNCLLLNP 560

Query: 307 VPCPGSD 313
           +      
Sbjct: 561 ICKDKWQ 567


>UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186D8F4
          Length = 792

 Score =  117 bits (293), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 31/114 (27%), Positives = 58/114 (50%), Gaps = 11/114 (9%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL---- 259
            D+    WYHG++ R  A+ +L+++GDFLVR     PG +VLS +  + ++ H ++    
Sbjct: 67  RDLRSHAWYHGSIPRTRAEEILESDGDFLVRDCTSQPGNFVLSTKC-KGQNLHFVINKVV 125

Query: 260 -----LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRS-EGRDRETSLNLIRPV 307
                +    + +  D  +  +S+LI Y+V +G  + S  G   +   N + P+
Sbjct: 126 LQPDTVYERIQFQFEDEAYDTVSDLITYYVGSGKVISSLSGARIQNPKNRLHPL 179


>UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, partial n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793081
          Length = 770

 Score =  117 bits (293), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 13/125 (10%)

Query: 195 SNCRAPTV----TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHT-PGKYVLSGRT 249
           SN   P+V     + ++ + W+HG L RE+   LL  EGDFLVR++      + VLS   
Sbjct: 517 SNNFLPSVIGSSVKSLIEEEWFHGVLPREEVVRLLTKEGDFLVRETTRNDENQTVLSVCW 576

Query: 250 AENEHKHLILLDN-HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
               HKH I+        R    +F  I ELI Y   + + V S      +   L +P+P
Sbjct: 577 GG--HKHFIVQTTSEGEFRFEGPSFPTIQELITYQYQSALPVTS-----RSGAILRQPIP 629

Query: 309 CPGSD 313
               +
Sbjct: 630 RERWE 634


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score =  117 bits (293), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 34/112 (30%), Positives = 51/112 (45%), Gaps = 7/112 (6%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
            V   +  + WYHG + R + Q LL  +GDFLVR+S   PG YVLS   +    KH ++ 
Sbjct: 518 EVERPLEQQTWYHGAIPRLEVQQLLTKDGDFLVRKSQEKPG-YVLSVHWS-GACKHFLVQ 575

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGS 312
           +  N       +F  I +LI  +  +   V       ++ + L RPV     
Sbjct: 576 NKDNMYCLDGESFHTIPQLIQQYQTSQQHVTK-----KSEVVLRRPVLKDKW 622


>UniRef50_B0WI58 Putative uncharacterized protein n=2 Tax=Culicini
           RepID=B0WI58_CULQU
          Length = 825

 Score =  116 bits (291), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 32/152 (21%), Positives = 62/152 (40%), Gaps = 17/152 (11%)

Query: 165 QANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQAL 224
           Q+ +           P   + S   +++          + D+    WYHG + R+ A+ +
Sbjct: 14  QSKSLGDLLDMETTTPDGGNESVALKKALEWEL--SLDSRDLRSHAWYHGPIPRQRAEEI 71

Query: 225 LKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL---------LDNHNRVRTRDRTFSN 275
           ++ EGDFLVR     PG YVL+ RT +    H ++         +    + +  D  +  
Sbjct: 72  VQKEGDFLVRDCVSQPGNYVLTCRT-KGPTLHFVINKLLIQPETVYERVQYQFEDDAYDT 130

Query: 276 ISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           + +LI ++V +       G   +   N + P+
Sbjct: 131 VPDLITFYVGSA-----SGARIQFPCNRLYPL 157


>UniRef50_UPI00006A1C30 UPI00006A1C30 related cluster n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI00006A1C30
          Length = 514

 Score =  116 bits (291), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 37/112 (33%), Positives = 51/112 (45%), Gaps = 14/112 (12%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
           D+    WYHG L R+DA+ LL + GDFL+R S  +PG YVLS   A  +  H  ++    
Sbjct: 22  DLRSHAWYHGPLPRQDAERLLVSNGDFLIRDSISSPGDYVLSCFCAGGQPLHFKIIAVAL 81

Query: 265 R---------VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           R          +     F NI  L+  +V +   V        T   +IRPV
Sbjct: 82  RPRRGIARTLYQLEQDQFDNIPALVRSYVGDRRKVSES-----TGAVIIRPV 128


>UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Takifugu rubripes
           RepID=UPI00016E7A57
          Length = 668

 Score =  116 bits (290), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 32/113 (28%), Positives = 49/113 (43%), Gaps = 13/113 (11%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL---- 260
           D+    WYHG L RE  +ALL+ +GDFLVR S   PG YVL+           I+     
Sbjct: 18  DLKSHAWYHGPLGREAGEALLERDGDFLVRDSSSAPGDYVLTCFWMNGPMHFKIIRVVLR 77

Query: 261 ----DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                +    +  +  F N+  LI +HV +   +      + +S  +  P+  
Sbjct: 78  PKQGYSRELFQFEEDRFDNVPALIRFHVGSRRPIS-----QASSAVIFHPITR 125


>UniRef50_A8P596 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P596_BRUMA
          Length = 119

 Score =  115 bits (289), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 40/103 (38%), Positives = 60/103 (58%), Gaps = 4/103 (3%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
            +  + WYHG + R  A+++L+ EGDFLVR S +T   +VLSG         L+L +N  
Sbjct: 11  GLDRQPWYHGEMERATAESMLRNEGDFLVRISPNTANNFVLSGIANSVARHFLLLDENDQ 70

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           +VR + + F  I ELI+YH    + + SEG    + L+LIRP+
Sbjct: 71  KVRKQQQVFETIVELIEYHRGENVPIISEG----SELHLIRPI 109


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score =  115 bits (288), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 32/111 (28%), Positives = 56/111 (50%), Gaps = 8/111 (7%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKH 256
           P++     GK WY+G L+R  A+ +L     +GDFL+R S+  P  + +S + A  ++KH
Sbjct: 225 PSMDGKFGGKQWYYGKLTRHQAEMVLNQRGVDGDFLIRDSESMPNDFSISLK-ALYKNKH 283

Query: 257 LILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             +L N        R FS + +L++++    +     G      L LI+P+
Sbjct: 284 FKVLLNDGFFCIGQRKFSTMEDLVEHYKKAPIFTSEHG----DKLYLIKPL 330


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score =  115 bits (287), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 30/90 (33%), Positives = 47/90 (52%), Gaps = 3/90 (3%)

Query: 204 EDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
           + + G+ W+ G +SR +A A+L+    EG FLVR+S+  PG+Y LS    E    + I  
Sbjct: 338 QGLEGEPWFRGRISRAEAAAMLQITKQEGCFLVRESETQPGEYTLSLSHNEGVRHYRIQH 397

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
                    +  F +I +LI+YH  NG  +
Sbjct: 398 IEGQYFVNENHRFDSIPQLIEYHKLNGGGI 427


>UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9VPU1_DROME
          Length = 548

 Score =  114 bits (286), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 31/128 (24%), Positives = 57/128 (44%), Gaps = 8/128 (6%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPG 241
           R +   +    +   P    ++ GK WY+G ++R     +L     +GDFL+R S+   G
Sbjct: 422 RRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMG 481

Query: 242 KYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSL 301
            Y +S + A   +KH  +    N      R F ++ +L+D++    +    +G      L
Sbjct: 482 DYSVSLK-APGRNKHFRVHVEQNMYCIGQRKFHSLDQLVDHYQRAPIYTNKQGE----KL 536

Query: 302 NLIRPVPC 309
            L+R +P 
Sbjct: 537 YLVRSLPK 544


>UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=Culicidae
           RepID=B0X2Z7_CULQU
          Length = 591

 Score =  114 bits (286), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 42/156 (26%), Positives = 69/156 (44%), Gaps = 19/156 (12%)

Query: 167 NASTSNDGFTVPAPPMRHRSSLHRQSFVSNCR--------APTVTEDV----VGKVWYHG 214
           N S  N   T+ AP +  R    R S  SN          A     D+        W+HG
Sbjct: 383 NQSALNAVPTMMAPELPPRRPDDRISSSSNFELTETDLEPAHETDTDLTAMMREYPWFHG 442

Query: 215 NLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH-NRVRT 268
            L+R +A  L+      + G FLVRQS+   G++VL+    + + KHL +  N   + R 
Sbjct: 443 TLARSEAAQLVLHNGISSHGVFLVRQSETRKGEFVLTF-NFQGKAKHLRMTLNDLGQCRV 501

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
           +   F +I+E++++   + + + S G    T  N +
Sbjct: 502 QHLWFPSITEMLEHFRQHAIPLESGGTADVTLTNFV 537


>UniRef50_A8WHN9 Novel protein similar to vertebrate breast cancer anti-estrogen
           resistance 3 (BCAR3) n=3 Tax=Danio rerio
           RepID=A8WHN9_DANRE
          Length = 841

 Score =  114 bits (286), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 27/95 (28%), Positives = 45/95 (47%), Gaps = 10/95 (10%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD---- 261
                WYHG + R+ A+ L++ +GDFL+R S  +PG YVL+ +  +N  +H  +      
Sbjct: 153 PRSHAWYHGAIPRQVAENLVQRDGDFLIRDSLSSPGNYVLTCQW-KNSPQHFKINKRVVA 211

Query: 262 -----NHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
                +  +       F +I  L+ Y+V N   V 
Sbjct: 212 MNEAYSRVQYLFEKEGFDSIPALVRYYVGNREPVS 246


>UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eutheria
           RepID=C9JAB9_HUMAN
          Length = 174

 Score =  114 bits (285), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 27/103 (26%), Positives = 51/103 (49%), Gaps = 4/103 (3%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAEN 252
           +   P++T    G  WY+G ++R  A+  L     EGDFL+R S+ +P  + +S + A+ 
Sbjct: 70  DYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLK-AQG 128

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGR 295
           ++KH  +           R FS + EL++++    +    +G 
Sbjct: 129 KNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGE 171


>UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3 n=43
           Tax=Euteleostomi RepID=BCAR3_HUMAN
          Length = 825

 Score =  114 bits (285), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 27/114 (23%), Positives = 56/114 (49%), Gaps = 15/114 (13%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +ED+    WYHG + R+ ++ L++ +GDFLVR S  +PG +VL+ +  +N  +H  +   
Sbjct: 146 SEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQW-KNLAQHFKINRT 204

Query: 263 ---------HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                      + +    +F +I  L+  +V N   +      +++   + +P+
Sbjct: 205 VLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPIS-----QQSGAIIFQPI 253


>UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NNY7_BRUMA
          Length = 303

 Score =  114 bits (285), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 35/126 (27%), Positives = 60/126 (47%), Gaps = 7/126 (5%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVL--S 246
            ++       + ++T+DV G  +YHG + R D + LLK EGDFL+R+++ TPG+ VL  S
Sbjct: 2   PKKEEEEAEDSVSITDDVKGADYYHGLIPRTDIEPLLKKEGDFLLRKTELTPGEIVLAIS 61

Query: 247 GRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
            R        ++  D             ++S+LI Y+ +    + +  + R     L RP
Sbjct: 62  VRHNNAVRHFMVNQDQDGSFYCEHHHEKSVSDLIQYYKSTKEPLSASSQAR-----LRRP 116

Query: 307 VPCPGS 312
           +  P  
Sbjct: 117 IERPQW 122


>UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun sequence n=2
           Tax=Chordata RepID=Q4RUN4_TETNG
          Length = 1136

 Score =  114 bits (284), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 33/125 (26%), Positives = 51/125 (40%), Gaps = 11/125 (8%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVL 245
             +        P+         WYHG L R  A+  L+     G +L+R+SD  PG +VL
Sbjct: 163 EEEVAFPLSAPPSNHSPPRMPRWYHGKLDRTIAEERLRQARNPGSYLIRESDRRPGSFVL 222

Query: 246 SGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
           S  +  N   H  ++          R FS++S+LI Y+      ++ E         L+ 
Sbjct: 223 SFLSMTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSYVSCLLKGE--------KLLS 274

Query: 306 PVPCP 310
           PV  P
Sbjct: 275 PVAPP 279



 Score = 79.4 bits (194), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 45/137 (32%)

Query: 207 VGKVWYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
            GKVWYHG++++++A  LL T G    FLVR SD+TPG Y L  RT +   +  I   ++
Sbjct: 355 EGKVWYHGHITKKEAYNLLMTVGQVCSFLVRPSDNTPGDYSLFFRTNDIIQRFKISPTSN 414

Query: 264 NRVRTRDRTF---------------------------------SNISELIDYHVNNGMAV 290
           N+     R +                                  ++ ++ID++    +  
Sbjct: 415 NQYMMGGRYYNRYEPICMLGHHFQSSGYHVFSFFLRFNCAASVDSVDDIIDHYKKEQI-- 472

Query: 291 RSEGRDRETSLNLIRPV 307
                      NL  PV
Sbjct: 473 -------VEGYNLKEPV 482


>UniRef50_B7PEL7 Signal transduction protein lnk-realted, putative n=1 Tax=Ixodes
           scapularis RepID=B7PEL7_IXOSC
          Length = 553

 Score =  113 bits (283), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 50/201 (24%), Positives = 80/201 (39%), Gaps = 23/201 (11%)

Query: 135 DRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFV 194
           DRRC   F+ D   +     +A  V    A     +  D     AP     ++    +  
Sbjct: 311 DRRCLPCFLSDKL-MKAAAESATAVGEPAAAGTPRSGADSVAAIAPAASPVAASGAATAD 369

Query: 195 SNCRAPT---------------VTEDVVGKVWYHGNLSREDAQALLKTEGD-----FLVR 234
           S    PT               + + +    W+HG LSR DA  L+  EG      FLVR
Sbjct: 370 SGASPPTTGGVPCEPEAREGGDLYQSLREYPWFHGTLSRSDAAQLVLREGPLGHGVFLVR 429

Query: 235 QSDHTPGKYVLSGRTAENEHKHL-ILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           QS+   G+ VL+    +   KHL + L+   + R +   F  I +++++   + + + S 
Sbjct: 430 QSETRKGECVLTF-NFQGRAKHLRMTLNPEEQCRVQHLWFQTIFDMLEHFRVHPIPLESG 488

Query: 294 GRDRETSLNLIRPVPCPGSDD 314
           G    T  + +   P PGS D
Sbjct: 489 GASDVTLTDFVLATPSPGSGD 509


>UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes related) tyrosine kinase
           (phosphoprotein NCP94), partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E47E92
          Length = 527

 Score =  113 bits (282), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 37/158 (23%), Positives = 68/158 (43%), Gaps = 7/158 (4%)

Query: 157 INVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNL 216
           +N +T       S  ++         + R+        SN +   +   +  + +YHG L
Sbjct: 155 LNSSTDSTTEQKSKRSNMANKMTKIFKVRAGHDSSHEPSNNQPTELR--LEEEEFYHGAL 212

Query: 217 SREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNI 276
            R++ +ALL  +GDF+VR+     G+YVLS + A       I +++ N  R     F  +
Sbjct: 213 PRKETEALLVNDGDFVVREKSDAWGRYVLSAKHASKVRHFPIQINDENMYRLEGDAFQTV 272

Query: 277 SELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDD 314
            ELI + +N+   V        +   L++PV    ++ 
Sbjct: 273 GELIRFQLNSRQPVTKA-----SQAILLKPVCRVRNEH 305


>UniRef50_Q8AVM4 Sh2d3c-prov protein n=7 Tax=Euteleostomi RepID=Q8AVM4_XENLA
          Length = 676

 Score =  113 bits (282), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 29/104 (27%), Positives = 47/104 (45%), Gaps = 10/104 (9%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
            + D     WYHG + RE +++L++  GDFL+R S  + G YVL+ R  +NE  H  +  
Sbjct: 30  NSSDPRSHAWYHGRIPREVSESLVQRNGDFLIRDSLTSLGDYVLTCRW-KNESLHFKINK 88

Query: 262 ---------NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRD 296
                       +      +F NI  L+ Y+V +   V  +   
Sbjct: 89  VMVKTSDSYTRIQYLFEQESFDNIPALVRYYVGSRRPVSEQSSA 132


>UniRef50_Q4S6Q5 Chromosome undetermined SCAF14724, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4S6Q5_TETNG
          Length = 803

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 8/97 (8%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD- 261
            E++    WYHG + R+ A+ L++ +GDFL+R S  +PG YVL+ +         I    
Sbjct: 28  CEELRSHAWYHGAIPRQVAENLVQRDGDFLIRDSLSSPGSYVLTSQWRNTAQHFKINKKV 87

Query: 262 ---NHNR----VRTRDRTFSNISELIDYHVNNGMAVR 291
              N        R     F ++  LI ++V N   V 
Sbjct: 88  VALNEAYTRVEFRLEREGFDSVPALIRFYVGNRKPVS 124


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 25/115 (21%), Positives = 53/115 (46%), Gaps = 3/115 (2%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAEN 252
           +   P    ++    W+ G + R  A+ +L   + +G FL+R+S+  PG + LS +   +
Sbjct: 45  DGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGND 104

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                +L D   +       F++++EL+DYH +  ++   +   R+      +P 
Sbjct: 105 VQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPT 159


>UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio RepID=A2BDR6_DANRE
          Length = 635

 Score =  112 bits (279), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 15/123 (12%)

Query: 178 PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSD 237
            +PP + +  L ++  +S+C       ++    WYHG +  E +++L++ EGDFL+R S 
Sbjct: 24  SSPPDKLKQELEKELKLSSC-------NLSSHGWYHGRIPWEVSESLVQQEGDFLIRDSL 76

Query: 238 HTPGKYVLSGRTAENEHKHLIL------LDNHNRVRT--RDRTFSNISELIDYHVNNGMA 289
            + G YVL+ R  +     LI        D + RV+    + TF ++  L+  +V N   
Sbjct: 77  SSIGDYVLTCRWNQKALHFLITKVLLRSYDTYTRVQYILEEETFYSVPALVHSYVGNKRP 136

Query: 290 VRS 292
           +  
Sbjct: 137 LTK 139


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  112 bits (279), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 38/139 (27%), Positives = 61/139 (43%), Gaps = 11/139 (7%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHT 239
               L       N  AP  +     + W+ G L+R  AQ+ L     +EG FL+R S+  
Sbjct: 44  SGRVLDSGLVPGNYLAPAESGQ--TQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKD 101

Query: 240 PGKYVLSGRTAENEHKHLILLDNHNRVRTR-DRTFSNISELIDYHV----NNGMAVRSEG 294
              YVLS R+ +    + +L  + NR      R FS+++EL+DY+     NN   + +  
Sbjct: 102 NVGYVLSVRSGDQVKHYKVLQTDQNRFYVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPC 161

Query: 295 RDRETSLNLIRPVPCPGSD 313
           +    S   + P P  G +
Sbjct: 162 KRNTLSTPALLPFPTIGWE 180



 Score = 93.2 bits (230), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 34/115 (29%), Positives = 49/115 (42%), Gaps = 8/115 (6%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHK 255
           P  T       WY+GN++R  A+ LL      +G FLVR S+    +Y +S R+      
Sbjct: 239 PLGTSLGWTGPWYYGNINRVKAEKLLLASQNKDGSFLVRISESHSDEYTISARSEGKVFH 298

Query: 256 HLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             I   +       DR +F+ + ELI Y+  N    RS G   E      RP+  
Sbjct: 299 FRIQRSSIGAYFVSDRISFATLGELISYYQRNN---RSLGVLLEEPCAQQRPLTP 350



 Score = 89.4 bits (220), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 5/93 (5%)

Query: 226 KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTR-DRTFSNISELIDYHV 284
            +EG FL+R S+     YVLS R+ +    + +L  + NR      R FS+++EL+DY+ 
Sbjct: 733 NSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKVLQTDQNRFYVEPGRRFSSLAELVDYYQ 792

Query: 285 ----NNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
               NN   + +  +    S   + P P  G +
Sbjct: 793 KTSLNNAGPLGNPCKRNTLSTPALLPFPTIGWE 825


>UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4I2_DROPE
          Length = 431

 Score =  112 bits (279), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 42/201 (20%), Positives = 78/201 (38%), Gaps = 22/201 (10%)

Query: 113 QGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSN 172
            G +  D       +A + D      H + +  ++  ID     I       +      +
Sbjct: 242 GGDEFNDLASEDEAVANDLDM-----HALILNGLNGDIDD--QPIKTVEEVIKEIDDIMD 294

Query: 173 DGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EG 229
           +  +    P    S +  ++      AP   +      W+H  +S  +A+ LL+    +G
Sbjct: 295 EAESPLDEPDTCESEVIEKAREVLGGAPVRRK------WFHPTISGIEAEKLLQEEGFDG 348

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR-TRDRTFSNISELIDYHVNNGM 288
            FL R S   PG + LS R   NE  H+ + +N +         F+ + EL+ Y++ NG 
Sbjct: 349 SFLARLSSSNPGAFTLSVRRG-NEVTHIKIQNNGDFFDLYGGEKFATLPELVQYYMENGE 407

Query: 289 AVRSEGRDRETSLNLIRPVPC 309
                G+    ++ L +P+ C
Sbjct: 408 LKEKNGQ----AIELKQPLIC 424


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score =  111 bits (277), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 28/101 (27%), Positives = 55/101 (54%), Gaps = 2/101 (1%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL 257
           P+   ++    WY+G ++R DA+ LL  K EG FL+R S+ +PG + LS +  +      
Sbjct: 49  PSNYIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFK 108

Query: 258 ILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
           +L D  ++       F++++EL++YH    ++   + + R+
Sbjct: 109 VLRDAQSKFFLWVVKFNSLNELVEYHRTASVSRSQDVKLRD 149


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score =  111 bits (277), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 32/103 (31%), Positives = 49/103 (47%), Gaps = 11/103 (10%)

Query: 211 WYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           WYHG L R  A+  L+     G +L+R+SD  PG +VLS  +  N   H  ++       
Sbjct: 181 WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVVNHFRIIAMCGDYY 240

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
              R FS++S+LI Y+ +    ++ E         L+ PV  P
Sbjct: 241 IGGRRFSSLSDLIGYYSHVSCLLKGE--------KLLYPVAPP 275



 Score =  104 bits (260), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 36/105 (34%), Positives = 54/105 (51%), Gaps = 12/105 (11%)

Query: 207 VGKVWYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
            GK+W+HG +S+++A  LL T G    FLVR SD+TPG Y L  RT EN  +  I    +
Sbjct: 347 EGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPN 406

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
           N+     R +++I ++ID++    +              L  PVP
Sbjct: 407 NQFMMGGRYYNSIGDIIDHYRKEQI---------VEGYYLKEPVP 442


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  110 bits (276), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 37/119 (31%), Positives = 59/119 (49%), Gaps = 12/119 (10%)

Query: 194 VSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAE 251
            SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R   
Sbjct: 239 PSNYVTPLNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEG 296

Query: 252 NEHKHLILLDNHNRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             + + I  D   +V  T++  F+ ++EL+ +H     +V  EG    T   L+ P P 
Sbjct: 297 RVYHYRISEDPDGKVFVTQEAKFNTLAELVHHH-----SVPHEGHGLITP--LLYPAPK 348


>UniRef50_UPI0000DB7594 PREDICTED: similar to CG9098-PA, isoform A n=1 Tax=Apis mellifera
           RepID=UPI0000DB7594
          Length = 797

 Score =  110 bits (276), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 22/149 (14%)

Query: 173 DGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNL---SREDAQALLKTEG 229
           D   +P  P         +  +          D+    WYHG+     R+ A+A +  +G
Sbjct: 114 DYSNLPMDPPE----ESTRKLLERELRLLDPRDLRSHAWYHGSTLRGGRKGAEAEVPNDG 169

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLIL---------LDNHNRVRTRDRTFSNISELI 280
           DFLVR     PG YVL+ R  + +  H ++         +    + +  D  F  +++LI
Sbjct: 170 DFLVRDCASQPGNYVLTVRW-KGQPLHFVINRVVIQPETVYERAQYQFEDEAFDTVADLI 228

Query: 281 DYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            ++V +G  +      + +   +I P P 
Sbjct: 229 TFYVGSGRPIS-----QASGARIITPKPR 252


>UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QDY0_BRUMA
          Length = 384

 Score =  110 bits (276), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 31/114 (27%), Positives = 52/114 (45%), Gaps = 9/114 (7%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAENEHKHLIL 259
              +    WYHG L R+D   LL  +G FLVR+++   G   + VLS +  + +  H I+
Sbjct: 5   EPGLEFAEWYHGLLPRKDINILLSKQGQFLVRETEIKKGEGLQLVLSVKWND-KTMHFII 63

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
                +V    R F++I  LI YH+ +   +       ++   L+  VP    +
Sbjct: 64  RHVDGKVFIEKRQFNSIHALIRYHLVSKDPIT-----DQSGAMLLHAVPRQSWE 112


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score =  110 bits (275), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 27/116 (23%), Positives = 56/116 (48%), Gaps = 8/116 (6%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAEN 252
           +   P    ++    W+ G + R  A+ +L   + +G FL+R+S+  PG + LS +   +
Sbjct: 45  DGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGND 104

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
                +L D   +       F++++EL+DYH +  ++     R+++  L  I  +P
Sbjct: 105 VQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVS-----RNQQIFLRDIEQMP 155


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score =  110 bits (275), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 30/122 (24%), Positives = 56/122 (45%), Gaps = 8/122 (6%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVL 245
              +   +   P+ +    G+ WY+GN++R  A+  L     EGDFL+R S+ +P  + +
Sbjct: 263 PAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSV 322

Query: 246 SGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
           S + A  ++KH  +    N      R F  + EL++++    +     G      L L+R
Sbjct: 323 SLK-ASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYKKAPIFTSEHGE----KLYLVR 377

Query: 306 PV 307
            +
Sbjct: 378 AL 379


>UniRef50_A2AK86 SH2 domain containing 3C (Fragment) n=4 Tax=Euteleostomi
           RepID=A2AK86_MOUSE
          Length = 236

 Score =  110 bits (275), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 30/103 (29%), Positives = 48/103 (46%), Gaps = 10/103 (9%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD- 261
           + D+    WYHG + RE ++ L++  GDFL+R S  + G YVL+ R   N+  H  +   
Sbjct: 54  STDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWH-NQALHFKINKV 112

Query: 262 --------NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRD 296
                    H R      +F ++  L+ YHV +  AV  +   
Sbjct: 113 VVKAGESYTHIRYLFEQESFDHVPALVRYHVGSRKAVSEQSGA 155


>UniRef50_UPI000186DA97 tyrosine-protein kinase transforming protein FPS, putative n=1
           Tax=Pediculus humanus corporis RepID=UPI000186DA97
          Length = 850

 Score =  110 bits (275), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 36/110 (32%), Positives = 53/110 (48%), Gaps = 9/110 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHT-PGKYVLSGRTAENEHKHLILLDN-H 263
           ++ + W+HG L RE+   LL+ EGDFLVR++      + VLS   A   HKH I+  N  
Sbjct: 481 LIDEEWFHGVLPREEVVRLLRHEGDFLVRETTRNDECQTVLSV--AWGGHKHFIVQTNLE 538

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
              R    +F  I ELI Y   +G+ V S      +   L +P+     +
Sbjct: 539 GHFRFEGPSFPTIQELILYQYQSGLPVTS-----RSGAILKKPILREVWE 583


>UniRef50_Q59HB0 SHC (Src homology 2 domain containing) transforming protein 1
           isoform p66Shc variant (Fragment) n=7 Tax=Euteleostomi
           RepID=Q59HB0_HUMAN
          Length = 377

 Score =  110 bits (275), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 44/128 (34%), Positives = 63/128 (49%), Gaps = 15/128 (11%)

Query: 155 TAINVNTFD----AQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP------TVTE 204
           + +NV   D    A   A   N      AP    R     + F    R P      ++ E
Sbjct: 205 SYVNVQNLDKARQAVGGAGPPNPAINGSAP----RDLFDMKPFEDALRVPPPPQSVSMAE 260

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
            + G+ W+HG LSR +A+ALL+  GDFLVR+S  TPG+YVL+G  +  + KHL+L+D   
Sbjct: 261 QLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQS-GQPKHLLLVDPEG 319

Query: 265 RVRTRDRT 272
            V   +  
Sbjct: 320 VVSVAEVW 327



 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 22/111 (19%), Positives = 41/111 (36%), Gaps = 8/111 (7%)

Query: 73  GEVKKENFPVDINISSKMIKIIKQ--SRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKN 130
             +K    P+ + +S+  + ++     ++I  H     SF + G    DT     Y+AK+
Sbjct: 2   SNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDP--DTAEYVAYVAKD 59

Query: 131 KDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPP 181
                R CH++  E    L   + + I    F+ +      N    V    
Sbjct: 60  P-VNQRACHIL--ECPEGLAQDVISTIG-QAFELRFKQYLRNPPKLVTPHD 106


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  110 bits (274), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 37/119 (31%), Positives = 59/119 (49%), Gaps = 12/119 (10%)

Query: 194 VSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAE 251
            SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R   
Sbjct: 238 PSNYVTPLNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEG 295

Query: 252 NEHKHLILLDNHNRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             + + I  D   +V  T++  F+ ++EL+ +H     +V  EG    T   L+ P P 
Sbjct: 296 RVYHYRISEDPDGKVFVTQEAKFNTLAELVHHH-----SVPHEGHGLITP--LLYPAPK 347


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  110 bits (274), Expect = 9e-23,   Method: Composition-based stats.
 Identities = 37/119 (31%), Positives = 59/119 (49%), Gaps = 12/119 (10%)

Query: 194 VSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAE 251
            SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R   
Sbjct: 247 PSNYVTPLNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEG 304

Query: 252 NEHKHLILLDNHNRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             + + I  D   +V  T++  F+ ++EL+ +H     +V  EG    T   L+ P P 
Sbjct: 305 RVYHYRISEDPDGKVFVTQEAKFNTLAELVHHH-----SVPHEGHGLITP--LLYPAPK 356


>UniRef50_UPI00006A5E95 PREDICTED: similar to HrSH2 n=1 Tax=Ciona intestinalis
           RepID=UPI00006A5E95
          Length = 572

 Score =  110 bits (274), Expect = 9e-23,   Method: Composition-based stats.
 Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 11/126 (8%)

Query: 174 GFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLV 233
           G  VP  P   +S   +++   + ++   T+++   +WYH  L RE+AQA++  +GDFL+
Sbjct: 12  GNLVPTFP---QSVETQKNLYRDVKSSNNTKEISNCLWYHFKLRREEAQAMVVNDGDFLL 68

Query: 234 RQSDHTPGKYVLSGRTAENEHKHLIL--------LDNHNRVRTRDRTFSNISELIDYHVN 285
           RQS  +   YVL+ R         I         +++          F +I  LI YH+ 
Sbjct: 69  RQSLSSVDDYVLTLRWNATVLHFKINKFVQRHDAVNSSTFFVFERAYFDSIYSLIMYHME 128

Query: 286 NGMAVR 291
           N + + 
Sbjct: 129 NQIPIS 134


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score =  109 bits (273), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 31/146 (21%), Positives = 65/146 (44%), Gaps = 10/146 (6%)

Query: 169 STSNDGFTVPAPPMRHRSSL----HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQAL 224
            + +   T+ +    +R++      +         P  + D   + WYHG++  ++A+ +
Sbjct: 65  GSPDPFPTLESLVSHYRNTPNSIKEKSGVFIELLYPVRSTDPTTERWYHGSIGAKEAERM 124

Query: 225 LKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELID 281
           L ++G    +LVR+S   PG++VL  + A    + +I   N         +F+++ ELI+
Sbjct: 125 LLSKGRLGSYLVRESQSQPGQFVLVVKCANGVQQVIISCRNKKYEIKSGPSFASLQELIE 184

Query: 282 YHVNNGMAVRSEGRDRETSLNLIRPV 307
           Y+V N           ++ + L  P 
Sbjct: 185 YYVMNPKL---HDVKDQSPIKLREPF 207



 Score = 90.1 bits (222), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 21/101 (20%), Positives = 45/101 (44%), Gaps = 8/101 (7%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           W+H +L+   A+ LL    +G FLVR S+   G + +S +    +  H+ + ++ +    
Sbjct: 5   WFHSSLNGSQAEELLTPLADGSFLVRPSESKHGDFTISVKC-NGKVTHIKIQNDGDSFLL 63

Query: 269 RD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                 F  +  L+ ++ N   +++         + L+ PV
Sbjct: 64  IGSPDPFPTLESLVSHYRNTPNSIK---EKSGVFIELLYPV 101


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  109 bits (273), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 37/119 (31%), Positives = 59/119 (49%), Gaps = 12/119 (10%)

Query: 194 VSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAE 251
            SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R   
Sbjct: 258 PSNYVTPLNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYDG 315

Query: 252 NEHKHLILLDNHNRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             + + I  D   +V  T++  F+ ++EL+ +H     +V  EG    T   L+ P P 
Sbjct: 316 RVYHYRISEDPDGKVFVTQEAKFNTLAELVHHH-----SVPHEGHGLITP--LLYPAPK 367


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score =  109 bits (272), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 30/122 (24%), Positives = 55/122 (45%), Gaps = 14/122 (11%)

Query: 195 SNCRAPTVTED---VVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRT 249
           SN  AP V      +    W+HG ++R DA+ LL  + +G FLVR+S + PG Y +    
Sbjct: 89  SNKAAPAVRHKEVKLTAMPWFHGKITRSDAEDLLTPRKDGLFLVRESTNYPGDYTMCVSF 148

Query: 250 AENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           A     + ++  ++      +  F N+++L++++         E         L +P+  
Sbjct: 149 AGEVEHYRVIFKDNKVTIDEEEYFENLTKLVEHY---------ERDADGLVCTLTQPLIK 199

Query: 310 PG 311
            G
Sbjct: 200 KG 201


>UniRef50_Q7K137 Lnk, isoform A n=13 Tax=Drosophila RepID=Q7K137_DROME
          Length = 723

 Score =  109 bits (272), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 39/155 (25%), Positives = 66/155 (42%), Gaps = 17/155 (10%)

Query: 167 NASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTE------DVVGK----VWYHGNL 216
           N   ++     P  P+R      R S  SN      TE      D+  +     W+HG L
Sbjct: 388 NELGTSPTSGPPDIPVRPHRGEQRLSASSNFDGIEGTENDADVADLTAEMSVFPWFHGTL 447

Query: 217 SREDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHNRVRTRD 270
           +R +A  ++        G FLVRQS+   G++VL+    +   KHL L +    + R + 
Sbjct: 448 TRSEAARMVLHSDAAGHGYFLVRQSETRRGEFVLTF-NFQGRAKHLRLTISEKGQCRVQH 506

Query: 271 RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
             F +I E++++  +N + + S G    T    + 
Sbjct: 507 LWFPSIQEMLEHFRHNPIPLESGGTSDVTLTEWVH 541


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  109 bits (272), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 33/105 (31%), Positives = 52/105 (49%), Gaps = 5/105 (4%)

Query: 182 MRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHT 239
           MR + S       SN  AP   +D+    WYH N+SR  A+ LLK+  +G FLVR+S  +
Sbjct: 101 MRSQRSGKEGYAPSNYIAPF--KDINRNPWYHSNISRNTAEYLLKSGVDGSFLVRESLSS 158

Query: 240 PGKYVLSGRTAENEHKHLIL-LDNHNRVRTRDRTFSNISELIDYH 283
           PG+Y ++ R       H  +  D         + F+ + +L+ +H
Sbjct: 159 PGEYSITLRCDGKARTHYRINHDARGYFVAAGKFFATVEQLVAHH 203


>UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria RepID=Q2VXS8_HUMAN
          Length = 764

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 33/113 (29%), Positives = 52/113 (46%), Gaps = 7/113 (6%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
           P V + +  ++WYHG + R +   LL   GDFLVR+S     +YVLS    +   +H I+
Sbjct: 391 PEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQ-EYVLSVLW-DGLPRHFII 448

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGS 312
               N  R     F +I  LID+ ++    +       ++ + L R VP    
Sbjct: 449 QSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTK-----KSGVVLHRAVPKDKW 496


>UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activating protein n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B62FA
          Length = 879

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 36/141 (25%), Positives = 53/141 (37%), Gaps = 18/141 (12%)

Query: 173 DGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEG 229
           D F    P           +  +   AP   +      WYHG L R  A+  L+     G
Sbjct: 45  DVFLENIPDDIQDIEEPDHTNNTTFSAPPENQ------WYHGRLDRFTAEERLRDASRLG 98

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
            +LVR+SD  PG YVLS         H  +           R F+++ +L+ Y+ +    
Sbjct: 99  SYLVRESDRKPGSYVLSYLGRTG-INHFRITAVCGDYYIGGRQFNSLMDLVAYYTHCSDL 157

Query: 290 VRSEGRDRETSLNLIRPVPCP 310
           ++ E         LI P P P
Sbjct: 158 LKKE--------RLIHPTPPP 170



 Score = 75.5 bits (184), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 3/80 (3%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           W+H N+++ +A  +L     G FLVR SD++PG Y L      N+ +   +     R   
Sbjct: 246 WFHPNVTKSEAVDMLVKAGPGSFLVRPSDNSPGDYSL-FFHINNQIQRFRIEKKGVRYLM 304

Query: 269 RDRTFSNISELIDYHVNNGM 288
             RTF  +  +I+ +    +
Sbjct: 305 GGRTFECLDAVINRYRKEQI 324


>UniRef50_UPI00015B5D64 PREDICTED: similar to LD41184p n=1 Tax=Nasonia vitripennis
           RepID=UPI00015B5D64
          Length = 858

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 33/150 (22%), Positives = 63/150 (42%), Gaps = 21/150 (14%)

Query: 169 STSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHG-NLS--REDAQALL 225
           S+     +        R  L R+  + +   P    D+    WYHG +L   R+ A+A +
Sbjct: 129 SSPRASMSQEPVEESVRKLLERELRLFDLIDP---RDLRSYAWYHGSSLPGGRKGAEAEI 185

Query: 226 KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL---------LDNHNRVRTRDRTFSNI 276
             +GDFLVR     PG YVLS R  + +  H ++         +    + +  D  F  +
Sbjct: 186 PNDGDFLVRDCSSQPGNYVLSVRH-KGQALHFVINKLVLQPDTVYERVQYQLEDEAFDTV 244

Query: 277 SELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
           ++L+ ++V +   +      + +   ++ P
Sbjct: 245 ADLVTFYVGSKRPIS-----QASGARIVNP 269


>UniRef50_Q8N5H7 SH2 domain-containing protein 3C n=39 Tax=Amniota RepID=SH2D3_HUMAN
          Length = 860

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 10/103 (9%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD- 261
           + D+    WYHG + RE ++ L++  GDFL+R S  + G YVL+ R   N+  H  +   
Sbjct: 212 STDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRW-RNQALHFKINKV 270

Query: 262 --------NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRD 296
                    H +      +F ++  L+ YHV +  AV  +   
Sbjct: 271 VVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGA 313


>UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS
          Length = 155

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 30/108 (27%), Positives = 53/108 (49%), Gaps = 9/108 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +  + W+H  +S  +A+ LL+    +G FL R S   PG + LS R   NE  H+ + +N
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVRRG-NEVTHIKIQNN 59

Query: 263 HNRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            +         F+ + EL+ Y++ NG      G+    ++ L +P+ C
Sbjct: 60  GDFFDLYGGEKFATLPELVQYYMENGELKEKNGQ----AIELKQPLIC 103


>UniRef50_Q5T189 SHC (Src homology 2 domain containing) transforming protein 1
           (Fragment) n=3 Tax=Homo sapiens RepID=Q5T189_HUMAN
          Length = 296

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 47/135 (34%), Positives = 68/135 (50%), Gaps = 19/135 (14%)

Query: 155 TAINVNTFD----AQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP------TVTE 204
           + +NV   D    A   A   N      AP    R     + F    R P      ++ E
Sbjct: 89  SYVNVQNLDKARQAVGGAGPPNPAINGSAP----RDLFDMKPFEDALRVPPPPQSVSMAE 144

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
            + G+ W+HG LSR +A+ALL+  GDFLVR+S  TPG+YVL+G  +  + KHL+L+D   
Sbjct: 145 QLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQS-GQPKHLLLVDPEG 203

Query: 265 RVRTRDRTFSNISEL 279
            VR     F+ + +L
Sbjct: 204 -VRWG---FAMLPKL 214


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 33/101 (32%), Positives = 55/101 (54%), Gaps = 10/101 (9%)

Query: 211 WYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+HGNLS ++A+ L+      G FLVR+S   PG +VLS RT E++  H+++  + N+  
Sbjct: 58  WFHGNLSGKEAERLILERGKNGSFLVRESQSKPGDFVLSVRT-EDKVTHVMIRWHENKYD 116

Query: 268 T-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
               + F  + ELI+++  N M          T ++L +P 
Sbjct: 117 VGGGQKFGTLCELIEHYKRNPMVEI-----CGTVVHLRQPF 152


>UniRef50_Q4SMI9 Chromosome 18 SCAF14547, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SMI9_TETNG
          Length = 609

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 31/104 (29%), Positives = 42/104 (40%), Gaps = 8/104 (7%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL---- 260
           D+    WYHG L RE A+ALL+  GDFLVR S  TP  YVL+           I+     
Sbjct: 15  DLSSHAWYHGPLRREAAEALLERNGDFLVRDSSSTPRDYVLTCFWMNMPMHFKIIRVVLR 74

Query: 261 ----DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
                +    +  +  F NI  LI  +V     +        + 
Sbjct: 75  PKKGYSRELFQFEEDRFDNIPALIRLYVGGRRPISQASGAVISH 118


>UniRef50_UPI00017B1E0A UPI00017B1E0A related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B1E0A
          Length = 680

 Score =  107 bits (268), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 31/104 (29%), Positives = 42/104 (40%), Gaps = 8/104 (7%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL---- 260
           D+    WYHG L RE A+ALL+  GDFLVR S  TP  YVL+           I+     
Sbjct: 15  DLSSHAWYHGPLRREAAEALLERNGDFLVRDSSSTPRDYVLTCFWMNMPMHFKIIRVVLR 74

Query: 261 ----DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
                +    +  +  F NI  LI  +V     +        + 
Sbjct: 75  PKKGYSRELFQFEEDRFDNIPALIRLYVGGRRPISQASGAVISH 118


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  107 bits (268), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 12/129 (9%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPG 241
           H  S H     SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG
Sbjct: 172 HSDSGHVGWVPSNYVTPLNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPG 229

Query: 242 KYVLSGRTAENEHKHLILLDNHNRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
           +  +S R     + + I  D+  +V  T +  F+ ++EL+ +H     +V  EG    T 
Sbjct: 230 QRSISLRYDGRVYHYRISEDSDGKVYVTAEAKFNTLAELVHHH-----SVLHEGHGLITP 284

Query: 301 LNLIRPVPC 309
             L+ P P 
Sbjct: 285 --LLYPAPK 291


>UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_DROER
          Length = 220

 Score =  107 bits (268), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 34/138 (24%), Positives = 58/138 (42%), Gaps = 13/138 (9%)

Query: 176 TVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFL 232
            +P  P++     H          P          W+H  +S  +A+ LL+    +G FL
Sbjct: 21  LMPLEPLQADQKRHGIVAEWQLTTPI----CWPTGWFHPTISGIEAEKLLQEQGFDGSFL 76

Query: 233 VRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR-TRDRTFSNISELIDYHVNNGMAVR 291
            R S   PG + LS R   NE  H+ + +N +         F+ + EL+ Y++ NG    
Sbjct: 77  ARLSSSNPGAFTLSVRRG-NEVTHIKIQNNGDFFDLYGGEKFATLPELVQYYMENGELKE 135

Query: 292 SEGRDRETSLNLIRPVPC 309
             G+    ++ L +P+ C
Sbjct: 136 KNGQ----AIELKQPLIC 149


>UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus CT10 oncogene homolog
           (avian)-like n=1 Tax=Ciona intestinalis
           RepID=UPI000180C238
          Length = 295

 Score =  107 bits (268), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 13/102 (12%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WY G +SR+D+Q  L  +  G FLVR S   PG YVLS  +  ++  H I+    NR++ 
Sbjct: 14  WYFGMVSRKDSQNKLLHQKHGSFLVRDSTTCPGDYVLSV-SENSKVSHYIINKQENRLKI 72

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
            D+ F ++ EL+D++  + +           +  LI P+P P
Sbjct: 73  GDQMFDSMPELLDFYKVHYL----------DTTTLIEPIPKP 104


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  107 bits (267), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 35/130 (26%), Positives = 54/130 (41%), Gaps = 14/130 (10%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTP 240
             RS   +    SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +P
Sbjct: 147 EVRSKNGQGWVPSNYITPVNS--LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSP 204

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
           G+  +S R     + + I      +V  T +  FS ++EL+ +H                
Sbjct: 205 GQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHST---------VADGL 255

Query: 300 SLNLIRPVPC 309
              L  P P 
Sbjct: 256 VTTLHYPAPK 265


>UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA
          Length = 1315

 Score =  107 bits (266), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 33/115 (28%), Positives = 50/115 (43%), Gaps = 9/115 (7%)

Query: 201  TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHT-PGKYVLSGRTAENEHKHLIL 259
            +    +  + W+HG L RE+   LL+ EGDFLVR++      + VLS     N HKH I+
Sbjct: 941  STNRPLHEEEWFHGVLPREEVVRLLRNEGDFLVRETTRNDESQTVLSVCW--NGHKHFIV 998

Query: 260  LDN-HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
                    R     F +I ELI +   + + V        +   L +PV     +
Sbjct: 999  QTTAEGHYRFEGPAFPSIQELIVHQYQSELPVTG-----RSGAVLRKPVLRERWE 1048


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score =  107 bits (266), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 30/112 (26%), Positives = 50/112 (44%), Gaps = 11/112 (9%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
            +  ++   W+HG +SRE A++LL  + +G FLVR+S H PG Y L     +    + + 
Sbjct: 92  ASGQLIPMPWFHGKISRELAESLLMPREDGLFLVRESAHFPGDYTLCVCFQDQVDHYRMQ 151

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
             N       +  FS++ EL+ ++         E         L +PV   G
Sbjct: 152 GKNGKLTIDEEVYFSSLEELVQHY---------EKDADGLCTRLRKPVVKQG 194


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score =  106 bits (265), Expect = 9e-22,   Method: Composition-based stats.
 Identities = 27/113 (23%), Positives = 54/113 (47%), Gaps = 3/113 (2%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLSGRTAENEHKH 256
           P     V    WY G +SR+ A+ +L      G FL+R+S+ +PG++ +S    +     
Sbjct: 49  PKNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHF 108

Query: 257 LILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            +L +   +    +  F++++EL+D++    +A + +   R+    L  P  C
Sbjct: 109 KVLREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGAC 161


>UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
            RepID=UPI000186E930
          Length = 1195

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 29/107 (27%), Positives = 57/107 (53%), Gaps = 10/107 (9%)

Query: 206  VVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
            +  + WYHG+++R +A+ LL+   EG +LVR S+     Y LS ++A+      I +DN+
Sbjct: 1089 LEKQTWYHGSITRVEAEDLLRSLKEGSYLVRNSESAKQDYSLSLKSAKGFMHMRIQIDNN 1148

Query: 264  -NRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
              +       + F++I ++I ++  N + +R         + L++PV
Sbjct: 1149 SGQFILGQFSKPFNSIPDMIRHYSVNKLPIRGA-----EHMCLLKPV 1190


>UniRef50_A2BDR5 SH2 domain containing 3C (Fragment) n=4 Tax=Euteleostomi
           RepID=A2BDR5_DANRE
          Length = 140

 Score =  106 bits (264), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 32/116 (27%), Positives = 58/116 (50%), Gaps = 15/116 (12%)

Query: 178 PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSD 237
            +PP + +  L ++  +S+C       ++    WYHG +  E +++L++ EGDFL+R S 
Sbjct: 32  SSPPDKLKQELEKELKLSSC-------NLSSHGWYHGRIPWEVSESLVQQEGDFLIRDSL 84

Query: 238 HTPGKYVLSGRTAENEHKHLIL------LDNHNRVRT--RDRTFSNISELIDYHVN 285
            + G YVL+ R  +     LI        D + RV+    + TF ++  L+  +V 
Sbjct: 85  SSIGDYVLTCRWNQKALHFLITKVLLRSYDTYTRVQYILEEETFYSVPALVHSYVG 140


>UniRef50_UPI0000612FE6 UPI0000612FE6 related cluster n=1 Tax=Bos taurus
           RepID=UPI0000612FE6
          Length = 689

 Score =  106 bits (264), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 37/152 (24%), Positives = 70/152 (46%), Gaps = 10/152 (6%)

Query: 167 NASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL- 225
           +  +++ G +VP P     S+    +            ++    W+HG LSR  A  L+ 
Sbjct: 417 HPCSASCGPSVPTPLTLPSSAAEEAAEPEAQAE--AELELSDYPWFHGTLSRVKAAQLVL 474

Query: 226 ----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHNRVRTRDRTFSNISELI 280
               +  G F++RQS+  PG+YVL+    + + KHL L L+ H +   +   F ++ +++
Sbjct: 475 AGGPRNHGLFVIRQSETRPGEYVLTF-NFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDML 533

Query: 281 DYHVNNGMAVRSEGRDRETSLNLIRPV-PCPG 311
            +   + + + S G    T  + +R   P PG
Sbjct: 534 RHFHTHPIPLESGGSADITLRSYVRAQGPPPG 565


>UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateria RepID=FPS_DROME
          Length = 1325

 Score =  106 bits (264), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 9/115 (7%)

Query: 201  TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQS-DHTPGKYVLSGRTAENEHKHLIL 259
            +    +  + W+HG L RE+   LL  +GDFLVR++  +   + VLS     N HKH I+
Sbjct: 950  STNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCW--NGHKHFIV 1007

Query: 260  LDN-HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
                    R     F++I ELI +  ++ + V       ++   L RPV     +
Sbjct: 1008 QTTGEGNFRFEGPPFASIQELIMHQYHSELPVT-----VKSGAILRRPVCRERWE 1057



 Score = 53.2 bits (126), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 28/152 (18%), Positives = 53/152 (34%), Gaps = 16/152 (10%)

Query: 89  KMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHK 148
           KMI+ +     +     S  S G+    G  +        ++KD    RC     +   K
Sbjct: 331 KMIEHVNGGSPVANG--SIISNGSNTSNGIQS-NKDSLCRQSKDLNALRCQE---KQKQK 384

Query: 149 LIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVG 208
           L+D++  A+N      +   S  +D  T+    + +  +  +Q   S          ++ 
Sbjct: 385 LVDMIKCALN--EVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGL---GIMN 439

Query: 209 KVWYHGNLSREDAQALLKTEGDFLVRQSDHTP 240
           +      + R     LL+  G    R+S   P
Sbjct: 440 E-----LMRRGGVLTLLRGRGRHFKRKSTPQP 466


>UniRef50_Q5ZM15 Putative uncharacterized protein n=3 Tax=Gallus gallus
           RepID=Q5ZM15_CHICK
          Length = 431

 Score =  106 bits (264), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 35/166 (21%), Positives = 62/166 (37%), Gaps = 52/166 (31%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVL 245
            + S V   + P   +D   + WYHG+L+ ++A+ LL      G FLVR+S   PG +VL
Sbjct: 88  EKNSNVIELKYPLNCQDPTSERWYHGHLTGKEAEKLLTEKGKPGSFLVRESQSKPGDFVL 147

Query: 246 SGRTAENEHK----------------------------------------H---LILLDN 262
           S  T E++ +                                        H   + LL  
Sbjct: 148 SVLTNEDKMETGDPQTSRDPRDDPLPGGQPACPRFACRAGPSWEPCALEPHRASVALLQP 207

Query: 263 HNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             +        F  +++L++++  N M  +S        ++L +P 
Sbjct: 208 DGKYDVGGGERFDTLTDLVEHYKKNPMVEKSGAV-----VHLKQPF 248



 Score = 89.4 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 42/108 (38%), Gaps = 8/108 (7%)

Query: 211 WYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+H N+S  +A+ LL T    G FL R S   PG + LS R  +      I         
Sbjct: 4   WFHPNISGIEAEKLLLTRGVHGSFLARPSKSNPGDFTLSVRRNDEVTHIKIQNTGDYYDL 63

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC--PGSD 313
                F+   EL+ Y+      +R         + L  P+ C  P S+
Sbjct: 64  YGGEKFARKPELVQYYTEQQGLLR---EKNSNVIELKYPLNCQDPTSE 108


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score =  105 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 30/130 (23%), Positives = 55/130 (42%), Gaps = 14/130 (10%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTP 240
             ++   +    SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +P
Sbjct: 353 EAQTKNGQGWVPSNYITPVNS--LEKHSWYHGPVSRNAAEHLLSSGINGSFLVRESESSP 410

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRT-FSNISELIDYHVNNGMAVRSEGRDRET 299
           G+  +S R     + + I   +  ++     + F+ ++EL+ +H      +         
Sbjct: 411 GQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLI-------- 462

Query: 300 SLNLIRPVPC 309
              L  P P 
Sbjct: 463 -TTLHYPAPK 471


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score =  105 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 25/86 (29%), Positives = 42/86 (48%), Gaps = 2/86 (2%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
            V   +    W+HG + RE+A+ LL  + +G FLVR+S + PG Y L     E    + I
Sbjct: 368 EVNAKLNAMPWFHGRIKREEAENLLKPREDGLFLVRESTNFPGDYTLCVCFNEKVEHYRI 427

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHV 284
               +      D  F N+ +L++++ 
Sbjct: 428 KYAENKLTIDDDEYFDNLGQLVEHYT 453


>UniRef50_Q9BRG2 SH2 domain-containing protein 3A n=12 Tax=Eutheria
           RepID=SH23A_HUMAN
          Length = 576

 Score =  105 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 36/126 (28%), Positives = 54/126 (42%), Gaps = 9/126 (7%)

Query: 198 RAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKH- 256
           + P   ED+ G+ WYHG LSR+ A+ALL+  GDFLVR S    G  V+S R   +     
Sbjct: 2   QVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFE 61

Query: 257 ---LILLDNHNR----VRTRDRTFSNISELIDYHVNNGMAVRSE-GRDRETSLNLIRPVP 308
              + L     R     +  D  F +I  L+  ++     +    G      +    P+ 
Sbjct: 62  VFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLR 121

Query: 309 CPGSDD 314
              S+D
Sbjct: 122 RSFSED 127


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 30/130 (23%), Positives = 55/130 (42%), Gaps = 14/130 (10%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTP 240
             ++   +    SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +P
Sbjct: 101 EAQTKNGQGWVPSNYITPVNS--LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSP 158

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRT-FSNISELIDYHVNNGMAVRSEGRDRET 299
           G+  +S R     + + I   +  ++     + F+ ++EL+ +H      +         
Sbjct: 159 GQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLI-------- 210

Query: 300 SLNLIRPVPC 309
              L  P P 
Sbjct: 211 -TTLHYPAPK 219


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 36/107 (33%), Positives = 56/107 (52%), Gaps = 14/107 (13%)

Query: 205 DVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
            +  + W+  + S+  A ALL     +G FLVR+S+ TPG Y LS    + + KH  +  
Sbjct: 276 GLESEPWFMADTSKAMASALLNMCGQDGAFLVRESESTPGSYSLSVFY-QGKLKHYKIKH 334

Query: 262 NHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           + +  R  +R TF++ISELI+YH +NG  +            L +PV
Sbjct: 335 DQDMYRVSERHTFASISELIEYHKHNGGGLV---------TRLRKPV 372


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 40/217 (18%), Positives = 65/217 (29%), Gaps = 26/217 (11%)

Query: 98  RLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAI 157
             I ++ F      +              +A +KD                L  ++    
Sbjct: 10  ECIGKYNFPG---SSPHDLPFKKGDRLVIVAPSKDPNW-----YKARREDGLEGMI--PF 59

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
           N          S        P  P+         +  +   A      +    W+HG +S
Sbjct: 60  NYVQEKVPVAGSAPQP----PQRPVLSAPQPVADNDAAMNHASKGAVQLKTMPWFHGRIS 115

Query: 218 REDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT-RDRTFS 274
           REDA+ LL     G FLVR+S + PG Y L          + +  +    V    D  F 
Sbjct: 116 REDAEKLLTPPKNGRFLVRESQNYPGDYTLCVSYDGRVENYRVRRNEKGLVTVDDDEYFD 175

Query: 275 NISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
           N+ +L++++                   L  PV   G
Sbjct: 176 NLIKLVEHYQK---------EADGLCTRLKAPVDKEG 203


>UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6 n=11 Tax=Eumetazoa
           RepID=C0H9A3_SALSA
          Length = 582

 Score =  105 bits (261), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 33/130 (25%), Positives = 58/130 (44%), Gaps = 17/130 (13%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVL 245
            +   +   + P    D   + WYHG+LS  +A+ LL      G FLVR+S   PG +VL
Sbjct: 88  DKDGTIIELKYPFNCSDPTTERWYHGHLSGPNAEKLLWERDEPGTFLVRESLSKPGDFVL 147

Query: 246 SGRTAEN--------EHKHLILLDNHNRVRTRD-RTFSNISELIDYHVNNGMAVRSEGRD 296
           S  T E            H+ ++  ++R        F  +++L++++   G+   S    
Sbjct: 148 SVLTEEKSKASSGGRRVSHIKIMCQNDRYTVGGKEMFDTLADLMEHYKRKGIEEMSG--- 204

Query: 297 RETSLNLIRP 306
             T ++L +P
Sbjct: 205 --TWVHLKQP 212



 Score = 88.6 bits (218), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 30/103 (29%), Positives = 46/103 (44%), Gaps = 8/103 (7%)

Query: 211 WYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+H ++S  DA+++LK+    G FL R S    G + LS R  E      I         
Sbjct: 4   WFHRDISGLDAESVLKSRGVHGSFLARPSRKNQGDFSLSVRVGELVTHIRIQNTGDFYDL 63

Query: 268 TRDRTFSNISELIDYHV-NNGMAVRSEGRDRETSLNLIRPVPC 309
                F+ +SEL++Y+   NG+    +G    T + L  P  C
Sbjct: 64  YGGEKFATLSELVEYYTAENGILQDKDG----TIIELKYPFNC 102


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  105 bits (261), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 15/130 (11%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPG 241
           H S        SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG
Sbjct: 149 HASPGQVGWVPSNYVTPVNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPG 206

Query: 242 KYVLSGRTAENEHKHLILLD--NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
           +  +S R     + + I  D  +     T +  F+ ++EL+ +H  +   +         
Sbjct: 207 QRSISLRYEGRVYHYRINEDTSDGKVYVTTESRFNTLAELVHHHSMHSDGLI-------- 258

Query: 300 SLNLIRPVPC 309
              L+ P P 
Sbjct: 259 -TQLLYPAPK 267


>UniRef50_B7QIL2 Dreadlocks/dock, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7QIL2_IXOSC
          Length = 372

 Score =  105 bits (261), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 27/116 (23%), Positives = 50/116 (43%), Gaps = 8/116 (6%)

Query: 198 RAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEH 254
           + P    ++  K WY G++ R     +L     +GDFL+R S+   G   +S + A   +
Sbjct: 262 QQPRGRPELRAKEWYFGSIPRSQCDQVLNECAQDGDFLIRDSETNVGDLSVSLK-APLRN 320

Query: 255 KHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
           KH  +           R FS + +L++++    +    +G      + L+RP   P
Sbjct: 321 KHFRVHVEDGVFCIGQRRFSQLDDLVEHYKRAPIYTSPKG----DKMFLVRPFKRP 372


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score =  104 bits (260), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 30/130 (23%), Positives = 55/130 (42%), Gaps = 14/130 (10%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTP 240
             ++   +    SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +P
Sbjct: 440 EAQTKNGQGWVPSNYITPVNS--LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSP 497

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRT-FSNISELIDYHVNNGMAVRSEGRDRET 299
           G+  +S R     + + I   +  ++     + F+ ++EL+ +H      +         
Sbjct: 498 GQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLI-------- 549

Query: 300 SLNLIRPVPC 309
              L  P P 
Sbjct: 550 -TTLHYPAPK 558


>UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambiae
           RepID=Q7QGU0_ANOGA
          Length = 837

 Score =  104 bits (260), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 37/152 (24%), Positives = 63/152 (41%), Gaps = 14/152 (9%)

Query: 166 ANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTED----VVGKVWYHGNLSREDA 221
              S + +       P +   +L     +   R      D    +  + WYHG++SR DA
Sbjct: 687 FKQSLTLNLNECGQRPPKKFGTLDLGLNLGTNRPNVDLIDASIPLDRQGWYHGSISRIDA 746

Query: 222 QALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD-NHNRVRTRD--RTFSNI 276
           + +L+  +EG FLVR S+ T   Y L+ ++A+      I  D +  +       R F  I
Sbjct: 747 EKILRPLSEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDADSGQFILGQFSRPFPTI 806

Query: 277 SELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
            ++I +   N + VR         + L+ PV 
Sbjct: 807 PDMIRHFCLNRLPVRGA-----EHMCLLEPVI 833


>UniRef50_UPI00017B2C65 UPI00017B2C65 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B2C65
          Length = 846

 Score =  104 bits (258), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 28/155 (18%), Positives = 59/155 (38%), Gaps = 15/155 (9%)

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSRED 220
           +    A++S     F+     +   S   ++      R    + ++    WYHG +  E 
Sbjct: 165 SLTGSADSSGEYVKFSKGKFWLEPLSENLKKQLEEELR--LSSTNLKSHAWYHGPIPWEV 222

Query: 221 AQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI--------LLDNHNRVRTRDRT 272
           +++L+   GDFL+R S    G +VL+    +     LI              +    +  
Sbjct: 223 SESLVVNHGDFLIRDSQSNRGNFVLTSNWQQKTLHFLIRKAALQPGETYPRVQYSLEEEA 282

Query: 273 FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           F ++  L+ ++V +   +      + +   + RPV
Sbjct: 283 FESLPALVHFYVGSRAPLT-----QWSGAQIQRPV 312


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score =  104 bits (258), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 36/140 (25%), Positives = 62/140 (44%), Gaps = 12/140 (8%)

Query: 176 TVPAPPMRHRSSLHRQSFVSNCRAPTVTED----VVGKVWYHGNLSREDAQALLK--TEG 229
            VP   +   +            AP  + +    +  + WY G +SRE A+ LL    EG
Sbjct: 262 LVPRNYIEVVNDSSSSKASHQDFAPQYSGNGEIPMEQQPWYFGRISRERAEDLLLHGREG 321

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
           +FLVR S+  PG   +S R  E  +KH  + +    ++  +RTF +++ LI+++  + + 
Sbjct: 322 EFLVRDSESNPGDLSISMRGIE-RNKHFKVQNVDGLLKIGNRTFVDMNALINHYTTSPIF 380

Query: 290 VRSEGRDRETSLNLIRPVPC 309
                      L L  P+P 
Sbjct: 381 -----SSPTEKLFLTGPLPK 395


>UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorhabditis briggsae
           RepID=A8XFT2_CAEBR
          Length = 577

 Score =  104 bits (258), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 29/119 (24%), Positives = 57/119 (47%), Gaps = 15/119 (12%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAE-----NEH 254
            +D+  + WYHG L RED +A+L+  GDFL+R ++   G   +YVLS    E        
Sbjct: 3   DKDIHTEPWYHGLLPREDIKAMLRKTGDFLIRSTEPKQGEARQYVLSAMQNEELEDAGVK 62

Query: 255 KHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
            +++ ++ +N++    + F  I+ L++Y++     ++           L  P+     +
Sbjct: 63  HYVMRVNANNQIFLETKGFETITSLVNYYMTTKDPIKK-------MTVLKTPIVKQDWE 114


>UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup RepID=Q7KV33_DROME
          Length = 1510

 Score =  103 bits (256), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 42/176 (23%), Positives = 66/176 (37%), Gaps = 14/176 (7%)

Query: 142  FIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLH-----RQSFVSN 196
             + D  K+   L TA+         N S                S+        Q +V+ 
Sbjct: 1336 SMRDDQKMSSKLDTALFRQNLTLNLNESRQATKQFGSLDLRGLNSNKELNMNLSQGYVTA 1395

Query: 197  CRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEH 254
                 VT  +  + WYHG ++R +A+  L+  +EG FLVR  + T   Y LS + A+   
Sbjct: 1396 VDLIDVTIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFM 1455

Query: 255  KHLILLDNHNRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
               I  +   +       R F  + E+I +   N + VR         + LI PV 
Sbjct: 1456 HMRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGA-----EHMCLIEPVI 1506


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score =  103 bits (256), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 31/102 (30%), Positives = 49/102 (48%), Gaps = 3/102 (2%)

Query: 204 EDVVGKVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
             +  + W+HG +SR +A ALL   K EG FLVR+S+   G+Y LS    ++   + I  
Sbjct: 295 AGIESEAWFHGRISRAEAAALLHVAKQEGCFLVRESESKVGEYSLSVSHGDSLRHYHIKK 354

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLN 302
           +           F +I +LI+YH  N   + +  R     L+
Sbjct: 355 EGEEFYINDRHRFPDICKLIEYHKLNSGGLVTRLRKSIADLH 396


>UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1 Tax=Tribolium
           castaneum RepID=D2A4V7_TRICA
          Length = 488

 Score =  102 bits (255), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 37/147 (25%), Positives = 63/147 (42%), Gaps = 20/147 (13%)

Query: 177 VPAPPMRH--RSSLHRQSFVSNCRAPTVTED-----------VVGKVWYHGNLSREDAQA 223
            P  P RH       R S  SN      T D           +  + W+HG L R +A  
Sbjct: 275 APELPPRHVSGRGGDRLSSSSNFDMCPSTGDNISMETDIGQTLKKEFWFHGTLGRSEATN 334

Query: 224 LLKTEGD-----FLVRQSDHTPGKYVLSGRTAENEHKHL-ILLDNHNRVRTRDRTFSNIS 277
           L+  +G      FLVRQS+   G++VL+    +   KHL + +++  + R +   F +I 
Sbjct: 335 LVLHDGARGHGLFLVRQSETRTGEFVLTF-NFQGRAKHLRMTINDQGQCRVQHFWFQSIY 393

Query: 278 ELIDYHVNNGMAVRSEGRDRETSLNLI 304
           E++++     + + S G    T  + +
Sbjct: 394 EMLEHFRQQPIPLESGGNSDVTLTDFV 420


>UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU33_DROPE
          Length = 1444

 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 30/111 (27%), Positives = 50/111 (45%), Gaps = 9/111 (8%)

Query: 202  VTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
            V+  +  + WYHG ++R +A+  L+  +EG FLVR  + T   Y LS + A+      I 
Sbjct: 1335 VSIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQ 1394

Query: 260  LDNHNRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
             +   +       R F  + ++I +   N + VR         + LI PV 
Sbjct: 1395 RNETGQYILGQFSRPFDTVPDMIRHFCLNRLPVRGA-----EHMCLIEPVI 1440


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 5/110 (4%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGK 242
           R         SN  AP  + D     WYHG +SR D++A+L +   G FLVR+S+ + G+
Sbjct: 170 RRLGEIGWVPSNFIAPYNSLD--KYTWYHGKISRSDSEAILGSGITGSFLVRESETSIGQ 227

Query: 243 YVLSGRTAENEHKHLILLDN-HNRVRTRDRTFSNISELIDYHVNNGMAVR 291
           Y +S R       + I +DN      T++  F  + EL+ +H  +   + 
Sbjct: 228 YTISVRHDGRVFHYRINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLI 277


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 27/113 (23%), Positives = 51/113 (45%), Gaps = 2/113 (1%)

Query: 188 LHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVL 245
              +        P    D+    W+H  LSR  A+ LL  K  G F++R S  +PG + +
Sbjct: 35  FKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSI 94

Query: 246 SGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
           S R  ++     ++ DN          F ++++L+DY+  N ++ + +   R+
Sbjct: 95  SVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRD 147


>UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186CA05
          Length = 1274

 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 31/115 (26%), Positives = 53/115 (46%), Gaps = 19/115 (16%)

Query: 208 GKVWYHGNLS--REDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
            ++W+HG L   R +A++LLK      +G FLVR+S+   G Y LS    + +  H  + 
Sbjct: 592 SEMWFHGKLGGKRAEAESLLKKYSHLGDGTFLVRESETFVGDYSLSF-WRQGKVNHCRIR 650

Query: 261 DNHN-----RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
              +            +F ++  LI Y+ ++ +      R +E  + L  PVP P
Sbjct: 651 SKQDKGQTKYYLIDTNSFDSLYSLITYYRSHPL------RSQEFLIVLKEPVPQP 699



 Score = 92.1 bits (227), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 30/128 (23%), Positives = 51/128 (39%), Gaps = 13/128 (10%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHT 239
           R      ++  +             GK WY  N++R  A+ +LK    +G FLVR S+  
Sbjct: 679 RSHPLRSQEFLIVLKEPVPQPNKHEGKEWYLPNVTRSQAEEMLKRVPTDGAFLVRPSERG 738

Query: 240 PGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
              Y +S R AE + KH  +  +          F ++ +LI Y+  + +  +        
Sbjct: 739 ANSYAISFR-AEKKIKHCRIKVDGRLYAIGSVYFESLVDLITYYERHPLYKK-------- 789

Query: 300 SLNLIRPV 307
            + L  PV
Sbjct: 790 -IRLCHPV 796


>UniRef50_UPI00017B392D UPI00017B392D related cluster n=2 Tax=Tetraodon nigroviridis
           RepID=UPI00017B392D
          Length = 610

 Score =  102 bits (253), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 36/140 (25%), Positives = 62/140 (44%), Gaps = 5/140 (3%)

Query: 179 APPMRHRSSLHRQSFV-SNCRAPTVTEDVVGKVWYHGNLSREDAQALLK----TEGDFLV 233
            P      +    SF+ S+  A  V   +    W+HG LSR  A  L+     + G FLV
Sbjct: 434 TPLAETPDAGGEGSFLFSDPVAEAVEHPLSECQWFHGTLSRLKAAQLVLGGPASHGVFLV 493

Query: 234 RQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           RQS+   G+YVL+           + L+   + R +   F +I +++++   + + + S 
Sbjct: 494 RQSETRRGEYVLTFNFQGKAKALRLSLNEDGQCRVQHLWFQSIFDMLEHFRVHPIPLESG 553

Query: 294 GRDRETSLNLIRPVPCPGSD 313
           G    T ++ +  V  PG D
Sbjct: 554 GASDVTLVSFVGAVRQPGRD 573


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 32/87 (36%), Positives = 45/87 (51%), Gaps = 5/87 (5%)

Query: 204 EDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
            D+  ++WYHG +SR DA+ LL    +  G FLVR S  T G+YVLS      ++ ++I 
Sbjct: 2   TDLSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKKYHYIIS 61

Query: 260 LDNHNRVRTRD-RTFSNISELIDYHVN 285
                 V  +D   F +  ELI YH  
Sbjct: 62  RHPDGSVAIQDGAKFDSPIELIQYHTK 88



 Score = 77.8 bits (190), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 23/111 (20%), Positives = 50/111 (45%), Gaps = 7/111 (6%)

Query: 207 VGKVWYHGNLSREDAQALLK----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
             ++W+HG +SRE+++  +K     +G FLVR+       + L      + + +L+ ++ 
Sbjct: 159 RKQLWFHGAISREESEQRMKAFGLRDGLFLVRE-RTEVNSFALCVAVKNDIYHYLLEMNT 217

Query: 263 HNRVRTR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI-RPVPCPG 311
             ++     R F N+ +++D++      +     D         + VP PG
Sbjct: 218 LGQLSIENGRKFENLLQVVDHYSRTPDGLLCTLVDVCAVTRFEAQAVPMPG 268


>UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related adapter protein 2 n=5
           Tax=Homo sapiens RepID=B7Z8F8_HUMAN
          Length = 304

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 30/120 (25%), Positives = 56/120 (46%), Gaps = 3/120 (2%)

Query: 182 MRHRSSLHRQSFVSNCRAP-TVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDH 238
           +   S L R+   ++   P         K W+H  LSR  A+ LL  K  G F++R S  
Sbjct: 2   LEFVSLLARKDSNNSVSKPRHKLNPFSSKRWFHEGLSRHQAENLLMGKEVGFFIIRASQS 61

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
           +PG + +S R  ++     ++ DN          F ++++L+DY+  N ++ + +   R+
Sbjct: 62  SPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRD 121


>UniRef50_UPI000179134F PREDICTED: similar to signal transduction protein lnk-realted,
           partial n=1 Tax=Acyrthosiphon pisum RepID=UPI000179134F
          Length = 474

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 41/210 (19%), Positives = 92/210 (43%), Gaps = 17/210 (8%)

Query: 118 TDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTV 177
            + E +   ++  +           +     L D ++    + + D   ++S ++   T+
Sbjct: 209 NNVEYIIDALSPEEMRQWLATVKYCMRKRDGLHDDISI---IGSIDGVLDSSVAHSNDTL 265

Query: 178 PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL-----KTEGDFL 232
            + P    ++L   + ++N     ++  +    W+HG L+R DA  L+        G FL
Sbjct: 266 LSSPQSSTNNLD--TILNNDVENDISASLRLYPWFHGMLARSDATNLVSHLGTNGHGMFL 323

Query: 233 VRQSDHTPGKYVLSGRTAENEHKHL-ILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
           VRQS+   G+YVL+    + + KHL + L++    R +  +F +I +++++   + + + 
Sbjct: 324 VRQSETRKGEYVLTF-NFKGKPKHLRMTLNDQGHCRVQHLSFPSIQDMLEHFQTHLIPLE 382

Query: 292 SEGRDRETSLNLIRPVPC-----PGSDDIE 316
           + G    T  + I   P      P + +I+
Sbjct: 383 NGGPGDVTLRDYILNTPIKYGVFPSNTNID 412


>UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS
          Length = 1495

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 30/111 (27%), Positives = 50/111 (45%), Gaps = 9/111 (8%)

Query: 202  VTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
            V+  +  + WYHG ++R +A+  L+  +EG FLVR  + T   Y LS + A+      I 
Sbjct: 1386 VSIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFMHMRIQ 1445

Query: 260  LDNHNRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
             +   +       R F  + ++I +   N + VR         + LI PV 
Sbjct: 1446 RNETGQYILGQFSRPFDTVPDMIRHFCLNRLPVRGA-----EHMCLIEPVI 1491


>UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=SH2B1_HUMAN
          Length = 756

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 37/143 (25%), Positives = 66/143 (46%), Gaps = 11/143 (7%)

Query: 174 GFTVPAPPMR-HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK-----T 227
             + P PP+    ++     F          + + G  W+HG LSR  A  L+      +
Sbjct: 489 PLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGS 548

Query: 228 EGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHNRVRTRDRTFSNISELIDYHVNN 286
            G FLVRQS+   G+YVL+    + + KHL L L+   + R +   F +I +++++   +
Sbjct: 549 HGVFLVRQSETRRGEYVLTF-NFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVH 607

Query: 287 GMAVRSEGRDRETSLNLIRPVPC 309
            + + S G    + + L+  VP 
Sbjct: 608 PIPLESGGS---SDVVLVSYVPS 627


>UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME
          Length = 954

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 33/118 (27%), Positives = 49/118 (41%), Gaps = 13/118 (11%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAEN 252
           N   P +      + WYHG L R  A++ L+     G +LVR+SD  PG YVLS      
Sbjct: 70  NGERPAIIAPPESE-WYHGRLDRYSAESRLRGSSKLGSYLVRESDRKPGSYVLSYYGRTG 128

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
              H  +           R F ++S+L+ Y+ +    ++ E         L  PV  P
Sbjct: 129 -INHFRITAVCGDFYIGGRQFISLSDLVGYYTSCSDLLKRE--------RLAIPVAPP 177



 Score = 74.7 bits (182), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 3/81 (3%)

Query: 210 VWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
            W+H N ++ +A  +L     G FLVR SD++PG Y L      N+ +   +     R  
Sbjct: 252 PWFHPNCTKNEAVDMLVKAGPGSFLVRPSDNSPGDYSL-FFHINNQIQRFRIEKKGVRYL 310

Query: 268 TRDRTFSNISELIDYHVNNGM 288
              RTF  +  +I+ +    +
Sbjct: 311 MGGRTFECLDAVINRYRKEQI 331


>UniRef50_O14492 SH2B adapter protein 2 n=4 Tax=Catarrhini RepID=SH2B2_HUMAN
          Length = 632

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 46/276 (16%), Positives = 95/276 (34%), Gaps = 38/276 (13%)

Query: 58  VTAAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKG 117
               +   P VS  +  + +    + + +  K    + +      +           QK 
Sbjct: 239 FVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETID---SLQKH 295

Query: 118 TDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTV 177
           +    + G +       D          +   +   +  +  +  D      T+  G  V
Sbjct: 296 SWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVV 355

Query: 178 PAPPMRHRS-------SLHRQSFVSNCRAPTVTE---------------------DVVGK 209
            AP  R R         +  ++F+    +P  +                      ++   
Sbjct: 356 TAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDY 415

Query: 210 VWYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNH 263
            W+HG LSR  A  L+     +  G F++RQS+  PG+YVL+    + + KHL L L+ H
Sbjct: 416 PWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTF-NFQGKAKHLRLSLNGH 474

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
            +   +   F ++ +++ +   + + + S G    T
Sbjct: 475 GQCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADIT 510


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 32/120 (26%), Positives = 52/120 (43%), Gaps = 12/120 (10%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQS 236
             R  ++       SN  AP  +  +  + WY G + R+DA+ LL       G FLVR+S
Sbjct: 130 EARSIATGKNGYIPSNYVAPADS--IQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRES 187

Query: 237 DHTPGKYVLSGRTAE----NEHKHLILL--DNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           + T G Y LS R  +    +  KH  +   DN     T    F  + +L+ ++  +   +
Sbjct: 188 ETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGL 247


>UniRef50_A2RUZ0 Zgc:158474 protein n=2 Tax=Euteleostomi RepID=A2RUZ0_DANRE
          Length = 906

 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 34/132 (25%), Positives = 60/132 (45%), Gaps = 7/132 (5%)

Query: 179 APPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK-----TEGDFLV 233
            P      +     F     + TV   +    W+HG LSR  A  L+      + G FLV
Sbjct: 683 TPFAETPDATGSFLFSDVSVSETVEHPLSECQWFHGTLSRLKAAQLVLAGGMASHGVFLV 742

Query: 234 RQSDHTPGKYVLSGRTAENEHKHLIL-LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRS 292
           RQS+   G+YVL+    + + KHL L L+   + R +   F +I +++++   + + + S
Sbjct: 743 RQSETRRGEYVLTF-NFQGKAKHLRLSLNEDGQCRVQHLWFQSIFDMLEHFRVHPIPLES 801

Query: 293 EGRDRETSLNLI 304
            G    T ++ +
Sbjct: 802 GGASDVTLISFV 813


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 35/151 (23%), Positives = 57/151 (37%), Gaps = 18/151 (11%)

Query: 168 ASTSNDGFTVPAPPMRHRSSLHRQSFVS------NCRAPTVTEDVVGKVWYHGNLSREDA 221
               ND  T         SSL  Q   S        +       +  + WYHG + R  A
Sbjct: 118 PVPPNDHSTTLNTGSASGSSLTFQHTSSHDVSCNGSQGSLARVGLESEKWYHGAIQRSYA 177

Query: 222 QALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR-TRDRTFSNISE 278
           + LL +   G FL+R+S+  PG+  +S R       + I  D+ N         F+++S+
Sbjct: 178 EYLLNSGITGSFLIRESESHPGQLTISLRYEGQIWHYRIHRDDSNMYYVIESNKFTSVSD 237

Query: 279 LIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           L+ +H  +             +  L+ P P 
Sbjct: 238 LVHHHEKHS---------DGLACTLLYPAPK 259


>UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicini RepID=B0WDQ7_CULQU
          Length = 1081

 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 10/123 (8%)

Query: 191  QSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGR 248
             +  SN      +  +  + WYHG++SR DA+ +L+   EG FLVR S+ T   Y L+ +
Sbjct: 960  NTARSNVDLIDASISLDRQGWYHGSISRIDAEKILRPLGEGSFLVRNSESTRQDYSLTLK 1019

Query: 249  TAENEHKHLILLDNH-NRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
            +A+      I  D   ++       R F  I ++I +   N + VR         + L+ 
Sbjct: 1020 SAKGFMHMRIQRDPDSSQYILGQFSRPFPTIPDMIRHFCLNRLPVRGA-----EHMCLLE 1074

Query: 306  PVP 308
            PV 
Sbjct: 1075 PVI 1077


>UniRef50_UPI00015B58E2 PREDICTED: similar to signal transduction protein lnk-realted n=1
           Tax=Nasonia vitripennis RepID=UPI00015B58E2
          Length = 458

 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 7/107 (6%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKH 256
           ++  +    W+HG L R DA  L+     +  G FLVRQS+   G+YVL+    +   KH
Sbjct: 261 LSSSLREYPWFHGTLPRSDAAQLVLHNATEGHGTFLVRQSETRKGEYVLTF-NFQGRAKH 319

Query: 257 L-ILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLN 302
           L + L +    R +  +F  I +++D+   N + + S G        
Sbjct: 320 LRMTLTDQGHCRVQHLSFPAIYDMLDHFRQNPIPLESGGTADVKLTE 366


>UniRef50_UPI000192756A PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI000192756A
          Length = 295

 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 27/100 (27%), Positives = 56/100 (56%), Gaps = 6/100 (6%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WYHG+++R   +++L  +  G FLVR S    G YVLS  +  N+  H I+ + +++ + 
Sbjct: 10  WYHGDITRPACESILMAQKPGLFLVRDSSTCKGGYVLSV-SENNKVSHYIITNKNSQYQI 68

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
            D+TF+++ E+++++  + +         E++  +  P P
Sbjct: 69  GDQTFNDLPEIVEFYKRHFLDTT---TLVESAPRVTEPTP 105


>UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y1_9METZ
          Length = 893

 Score =  100 bits (250), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 35/172 (20%), Positives = 65/172 (37%), Gaps = 15/172 (8%)

Query: 139 HVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCR 198
           H +       +      A         A  + S+   +         +        S   
Sbjct: 462 HRMQSNTSQSIDSTEGEAGEPGEPGETATDAASSADPSAIVEDNESETG-------STTD 514

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
            P  T  V  + W++ N+ R++A+   K  GD+L+R S     +YVL+   A  + KH +
Sbjct: 515 VPPETR-VEEERWFYPNMERKEAEEKCKNTGDYLIRYS-SKQNRYVLTVCWA-GQGKHFV 571

Query: 259 LLDNHN-----RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
           + +  +     + R   R+F ++ EL+D+HVN+   V        +   L  
Sbjct: 572 IQEAPDEQTKTKYRFESRSFPSVRELLDFHVNSQTPVTKASGAILSRPILRE 623


>UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homology 2 domain
           containing transforming protein D (SHD) n=1 Tax=Danio
           rerio RepID=A8WHR4_DANRE
          Length = 321

 Score =  100 bits (250), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 38/167 (22%), Positives = 72/167 (43%), Gaps = 10/167 (5%)

Query: 145 DVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTE 204
           +  + I+V   A + +      + +    G +  +PP    +SL +   +   R   +  
Sbjct: 156 EAQRFINVTFEAADWDQCTLPCDEALRKAGVSRVSPPSSGATSLRKPHGILGERVDPMLP 215

Query: 205 DVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
            +  +VWYHG L+R +A++LL    E  +LVR+S  +   Y LS R+             
Sbjct: 216 -LEKQVWYHGALTRSEAESLLTLCKECSYLVRKSQTSRNDYSLSLRSCHGFMHMKFSQSR 274

Query: 263 HNRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             +    + +  F +I E+I ++  N + +R         L+L+ PV
Sbjct: 275 DGKFILGENSPPFDSIPEVIHFYTTNKLPIRGA-----EHLSLLFPV 316


>UniRef50_Q18684 Protein T13H10.1, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q18684_CAEEL
          Length = 533

 Score =  100 bits (249), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 33/112 (29%), Positives = 57/112 (50%), Gaps = 9/112 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGK---YVLSGRTAENE-HKHLILLD 261
           +  + WYHG L RED + LL   GDFLVR +D   G+   +VLS      E  +H ++ +
Sbjct: 11  LAKEPWYHGLLPREDMKQLLTQRGDFLVRFTDPKVGEPRKFVLSVYVGVIEDIRHYVIRE 70

Query: 262 NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           ++N+     + FS+I++L++Y+  +   V            +IRP+     +
Sbjct: 71  HNNKFAVDKKWFSSIADLLNYYHRSKEPVAGGP-----ETVIIRPIGREPWE 117


>UniRef50_A8Q5H2 Protein-tyrosine phosphatase containing protein n=1 Tax=Brugia
           malayi RepID=A8Q5H2_BRUMA
          Length = 652

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 30/108 (27%), Positives = 58/108 (53%), Gaps = 9/108 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
              + W+H  LS  +A+ LL      G +LVR+S  +PG++ +S + A+++  H+++   
Sbjct: 135 PSTERWFHAGLSGPEAERLLLAEGKHGTYLVRESHSSPGQFAISVKAADDKVIHVMIYSK 194

Query: 263 HNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            ++       TFS ISEL++++  N M  ++      T +NL + +P 
Sbjct: 195 SDKFDIGGGATFSTISELLEHYTRNPMVDQAG-----TVVNLKQLLPS 237



 Score = 81.3 bits (199), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 30/100 (30%), Positives = 50/100 (50%), Gaps = 6/100 (6%)

Query: 212 YHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR- 267
           ++  +S  DA+ LL T   EG FL R S  +P  Y LS     +  KH+ + +N + +  
Sbjct: 25  FYYPISGVDAERLLNTCGTEGSFLARPSGSSPSNYTLSV-HRGDRIKHVKIQNNGDCLDL 83

Query: 268 TRDRTFSNISELIDYHVNNGMAVR-SEGRDRETSLNLIRP 306
               TF+++SEL+ ++V N   +R  +G        L+ P
Sbjct: 84  YGGETFASLSELVQFYVENPGQLRERDGEIIVLKCPLVIP 123


>UniRef50_UPI00016E9884 UPI00016E9884 related cluster n=7 Tax=Takifugu rubripes
           RepID=UPI00016E9884
          Length = 843

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 27/149 (18%), Positives = 54/149 (36%), Gaps = 10/149 (6%)

Query: 151 DVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKV 210
             L    + +     A+ S     F+     +   S   ++      R      ++    
Sbjct: 140 QDLIEDPHEDNLKGSADTSGDYVKFSKDKFWLEPPSENLKKQLDDELR--LSGTNLKSHA 197

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD--------N 262
           WYHG +  E A++L+   G+FL+R S    G +VL+    +     LI            
Sbjct: 198 WYHGPVPWEVAESLVVNHGEFLIRDSRSNHGDFVLTCHWQQKTLHFLIRRTVLQSSETYT 257

Query: 263 HNRVRTRDRTFSNISELIDYHVNNGMAVR 291
             +    +  F ++  L+ ++V +  A+ 
Sbjct: 258 RVQYSLEEEAFDSLPALVHFYVGSKAALT 286


>UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Tribolium
           castaneum RepID=UPI0001757D4E
          Length = 898

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 52/108 (48%), Gaps = 10/108 (9%)

Query: 206 VVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +  + W+HG ++R +A+ +L+   EG FLVR S+ T   Y LS ++A       I  D +
Sbjct: 792 LEKQGWFHGAITRVEAENVLRMLREGSFLVRNSESTKQDYSLSLKSARGFMHMRIQKDGN 851

Query: 264 NRVRT---RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
           +         + F +I E+I +   N + +R         + L++PV 
Sbjct: 852 DECYILGQFSKPFHSIPEMIRHFCINRLPIRGA-----EHMCLLQPVI 894


>UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7PSP3_IXOSC
          Length = 674

 Score = 99.4 bits (246), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 57/287 (19%), Positives = 97/287 (33%), Gaps = 34/287 (11%)

Query: 41  RVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLI 100
           +  V  E I      V    +R  +          KK N  +D   S       +    I
Sbjct: 144 QQTVQQEAID-CWQAVMRDYSRHTDFCSEAFQSVHKKLNESIDFIKSES-----EYQDFI 197

Query: 101 QRH---PFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAI 157
           +++   P     F        D  L+  Y+ K K           I+ + +   V   A+
Sbjct: 198 EKYKSKPIPPIDF------HYDESLLNNYVGKLK-PEQIAVDEFTIDALRERAMVKKRAV 250

Query: 158 NVNTFDAQANASTSNDGF----TVPAPPMRHRSSLHRQSFVS---NCRAPTVTED--VVG 208
           ++   +                 +  P     S + R   +    N    +V  +  +  
Sbjct: 251 DIIRRERDEIKCQEERINSQLQLLVQPLSSIGSEVPRGLDLDITVNGEQMSVNPNVVLQD 310

Query: 209 KVWYHGNLSREDAQALLKTEGDFLVRQS-DHTPGKYVLSGRTAENEHKHLILLDN-HNRV 266
           + W+HG L RE+   LL   GD+LVR++  +   + VLS       HKH I+      + 
Sbjct: 311 EDWFHGVLPREEVVRLLVNNGDYLVRETMRNEEKQVVLSVCWQG--HKHFIVQTTSDGKY 368

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           R     F  + ELI Y  + G+ V S     ++   L  P+     +
Sbjct: 369 RFEGPAFGTVQELIVYQHHLGLPVTS-----KSGAILQNPIFRERWE 410


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score = 99.4 bits (246), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 27/146 (18%), Positives = 57/146 (39%), Gaps = 18/146 (12%)

Query: 171 SNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---- 226
            N   +     + +  +  +    ++  A + +  +    W+ G ++R  A+  L     
Sbjct: 199 VNKDPSKEWTLVENCVTGCQGFVPTSFIAASAS--LESHAWFFGKIARSKAEKFLNDPRC 256

Query: 227 TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD---RTFSNISELIDYH 283
             G FL+R+S+ +PG+Y LS R  +    + +        + +    + F+++ ELI +H
Sbjct: 257 HHGSFLIRESESSPGQYSLSLRDGDTVRHYRVENYEGGLYKLQGSPTQKFASLPELIAFH 316

Query: 284 VNNGMAVRSEGRDRETSLNLIRPVPC 309
                      R    +  L  P P 
Sbjct: 317 ---------GQRKAGLATALREPCPK 333


>UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Gallus gallus RepID=UPI0000ECA6D9
          Length = 506

 Score = 99.0 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 10/123 (8%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQAL-----LKTEGDFLVRQSDHTPGKYVLSGRTAENE 253
            P + + +    W+HG +SR  A  L     L+  G FLVRQS+   G+YVL+    +  
Sbjct: 376 GPKMEQFLSSCPWFHGPISRVKAAQLVQLGGLEGHGVFLVRQSETRRGEYVLTF-NFQGR 434

Query: 254 HKHLIL-LDNHNRVRTRDRTFSNISELIDYHVNNGMAVR--SEGRDRETSLNLIRP-VPC 309
            KHL L L    + R +   FS+I+E++ +     + +   +    R +S  ++ P  P 
Sbjct: 435 AKHLRLSLTERGQCRVQHLRFSSITEMLHHFHRYPIPLECGATCDVRLSSYVVVLPQAPA 494

Query: 310 PGS 312
           PGS
Sbjct: 495 PGS 497


>UniRef50_UPI00006A1A97 SH2B adapter protein 2 (SH2 and PH domain-containing adapter
           protein APS) (Adapter protein with pleckstrin homology
           and Src homology 2 domains). n=3 Tax=Xenopus (Silurana)
           tropicalis RepID=UPI00006A1A97
          Length = 591

 Score = 99.0 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 20/127 (15%)

Query: 205 DVVGKVWYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
           ++    W+HG LSR  A  L+     ++ G F++RQS+  PG+YVL+    + + KHL L
Sbjct: 457 NLSDFPWFHGTLSRIRAAQLVLSGGTRSHGLFVIRQSETRPGEYVLTF-NFQGKAKHLRL 515

Query: 260 LDNH-NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI-------------R 305
             N   +   +   F  I +++ +  ++ + + S G    T  + +              
Sbjct: 516 SLNETGQCHVQHLWFQTIFDMLKHFHSHPIPLESGGSADITLRSFVVAQRQLSDPAPPQN 575

Query: 306 PVPCPGS 312
           PV  P S
Sbjct: 576 PVSPPES 582


>UniRef50_UPI000052352E PREDICTED: similar to RAS p21 protein activator 1 n=1 Tax=Ciona
           intestinalis RepID=UPI000052352E
          Length = 936

 Score = 98.6 bits (244), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 29/103 (28%), Positives = 41/103 (39%), Gaps = 11/103 (10%)

Query: 211 WYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           WYHG L R  A+  L      G +LVR+S   PG YVLS  +      H  ++       
Sbjct: 58  WYHGKLDRRIAEERLLEVNVAGGYLVRESQKKPGSYVLSFLSENIGMTHFRIISVCGDFY 117

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
              R F  + +LI Y+ +    +  E         L  P+  P
Sbjct: 118 IGGRQFECLEQLIAYYTHRSCLLEGE--------VLRTPIQPP 152



 Score = 91.7 bits (226), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 12/106 (11%)

Query: 207 VGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
            GK W+H  +++E+A +LL      G FL+R SD TPG YVL   T +   +  +     
Sbjct: 225 EGKEWFHAGITKEEAYSLLSAVDRSGSFLIRVSDSTPGDYVLYFFTGQYIQRFKLHRVGQ 284

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           NR     R + +I E+++++ +  +    EG        L   VP 
Sbjct: 285 NRFEMGGRCYGSIDEVVEHYRHEQIV---EGHT------LTYAVPK 321


>UniRef50_A9UWT7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UWT7_MONBE
          Length = 427

 Score = 98.2 bits (243), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 42/192 (21%), Positives = 72/192 (37%), Gaps = 15/192 (7%)

Query: 18  SLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGV-TAAREINPVVSRVIGEVK 76
           S    Y+GS+ VV+S+  + +  +  +  E I        +    R+  P     + +  
Sbjct: 51  SYPVRYVGSIQVVQSLRSLSTPEKTAICREAINRTGEAAKLIKVKRKAPPRAKEFLADTP 110

Query: 77  KENF-PVDINISSKMI--KIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDG 133
                 + INIS+K I    I +  ++   P +  SF A G     +   F Y+AK++  
Sbjct: 111 FLKVLDLKINISAKGIVTTSIPKREILANDPIAKISFAAGG--VDKSYFWFTYVAKDRRD 168

Query: 134 TDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSF 193
             R CHV    D   L D +   +         +   +N+     APP+        Q  
Sbjct: 169 N-RYCHVF---DGGALADDILATLGQ-----VFSLLATNNLPVKSAPPLPPNHPSLLQGA 219

Query: 194 VSNCRAPTVTED 205
            +   AP + E 
Sbjct: 220 AALAAAPKMPEG 231


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score = 98.2 bits (243), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 30/111 (27%), Positives = 52/111 (46%), Gaps = 9/111 (8%)

Query: 207 VGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTP--GKYVLSGRTAENEHKHLILLD 261
               WY G +SR+ A+  L +   +G F++R S+  P  G + LS +  +      IL D
Sbjct: 58  KSHPWYVGKISRKVAEEYLMSMPSDGAFMIRDSESNPDSGNFSLSVKFRDQVQHFKILTD 117

Query: 262 NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNL----IRPVP 308
              +       F++I++L+DYH +N ++   E    E  + +     RP P
Sbjct: 118 LAGKYFLWVVKFTSINDLVDYHKDNSVSRTQEIVLNEPCVPIEDANQRPQP 168


>UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2IB48_CHAVR
          Length = 1322

 Score = 98.2 bits (243), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 35/127 (27%), Positives = 53/127 (41%), Gaps = 14/127 (11%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVV-GKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTP 240
           +  L  Q F    + P        GK WYH  L R  A+ +LK    +G FLVRQ+    
Sbjct: 645 KYPLRSQDFQQILKEPVPQPQSHHGKPWYHEKLDRTRAEDMLKRIPSDGAFLVRQNGVDT 704

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
             Y +S R AE + KH I+          +  F ++ EL++Y+    +  +         
Sbjct: 705 NSYAISFR-AEGKIKHCIIKQEGRLFTIGNAQFESLVELVNYYEKKPLYRK--------- 754

Query: 301 LNLIRPV 307
           + L  PV
Sbjct: 755 MKLKHPV 761



 Score = 93.6 bits (231), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 31/117 (26%), Positives = 48/117 (41%), Gaps = 19/117 (16%)

Query: 208 GKVWYHGNL--SREDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
            + W+HG L   R  A+ LLK      +G FLVR+SD   G + LS    ++   H  + 
Sbjct: 557 SEKWFHGKLEGGRRKAEDLLKEYSYLGDGTFLVRESDTFVGDFSLSF-WRKDSVNHCRIR 615

Query: 261 DNHNR-----VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGS 312
               R         +  F ++  LI ++    +      R ++    L  PVP P S
Sbjct: 616 SKQERGQTKYYLIDNLAFDSLYSLITHYQKYPL------RSQDFQQILKEPVPQPQS 666


>UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gamma, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI00019263B9
          Length = 967

 Score = 97.8 bits (242), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 33/119 (27%), Positives = 56/119 (47%), Gaps = 18/119 (15%)

Query: 203 TEDVV-GKVWYHGNLSREDAQALLKT----EGDFLVRQSDHTPGKYVLSGRTAENEHKHL 257
            ED+   + W+H N+SR++A++LL+     +G FLVR S+   G + LS    +N  +H 
Sbjct: 313 DEDLHFSEKWFHRNISRQEAESLLQEYQRGDGSFLVRPSNMFVGDFSLSF-WRKNRVQHC 371

Query: 258 ILL---DNHN---RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
            +     N           + F N+  LI+++  N +      +  +  L L  PVP P
Sbjct: 372 HIKSRPTNDGTAKYFLVGPKGFDNLYSLINHYQTNPL------KSDKFELMLTEPVPQP 424



 Score = 82.8 bits (203), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 35/157 (22%), Positives = 54/157 (34%), Gaps = 23/157 (14%)

Query: 161 TFDAQANASTSND-GFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDV---VGKVWYHGNL 216
           T D  A        GF      + H  +   +S                 +GK WYH NL
Sbjct: 378 TNDGTAKYFLVGPKGFDNLYSLINHYQTNPLKSDKFELMLTEPVPQPNAHLGKDWYHENL 437

Query: 217 SREDAQALLK---TEGDFLVRQSDHTPGK----YVLSGRTAENEHKHLILLDNHNRVRTR 269
           +R  A+ +L+    +  FLVR      G     Y +S RT     KH ++          
Sbjct: 438 TRLQAEEMLRRMRKDSYFLVR--KRNDGDQNESYAISFRTG-GTIKHCVIKKEGRLFMIG 494

Query: 270 DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
              F +++ELI ++  N +  +           L  P
Sbjct: 495 TAPFESLTELIAHYEKNPLYRK---------TKLKYP 522


>UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O97034_9METZ
          Length = 1283

 Score = 97.8 bits (242), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 31/92 (33%), Positives = 50/92 (54%), Gaps = 9/92 (9%)

Query: 208 GKVWYHGNLSREDAQALLKT---EGDFLVRQSD--HTPGK--YVLSGRTAENEHKHLIL- 259
           GK W+H NLSR +A+ +LK    +G FL+R S+     G+  Y +S R AE + KH  + 
Sbjct: 652 GKAWFHENLSRSEAEEMLKKVRMDGAFLIRPSEQNTKAGQKNYAISFR-AEGKVKHCRIE 710

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
           +D   +       F +++EL+ Y+  N +  R
Sbjct: 711 VDESGQYCIGSAIFDSLTELVQYYEANPLYRR 742



 Score = 91.7 bits (226), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 35/135 (25%), Positives = 53/135 (39%), Gaps = 18/135 (13%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNL--SREDAQALLKT----EGDFLVRQSDH 238
           +         +N      TE  + + W+HG L   R  A+ LL       G FLVR+S  
Sbjct: 518 KDEDEADKTETNTETLPSTEQHLKEKWFHGKLAGGRVAAEKLLTDYKDVNGAFLVRESTT 577

Query: 239 TPGKYVLSGRTAENEHKHLILLDN----HNRVRTRDRT-FSNISELIDYHVNNGMAVRSE 293
             G Y LS    + ++ H  +         R    D+T F +I ELI ++ +N +     
Sbjct: 578 FTGDYSLSF-VRDGKYNHCRIHTKSEGGKTRFYLIDQTLFDSIYELIMHYKSNPL----- 631

Query: 294 GRDRETSLNLIRPVP 308
            +       L  PVP
Sbjct: 632 -KSPTFEQVLAEPVP 645


>UniRef50_Q4SW52 Chromosome undetermined SCAF13690, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SW52_TETNG
          Length = 338

 Score = 97.8 bits (242), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 29/102 (28%), Positives = 45/102 (44%), Gaps = 12/102 (11%)

Query: 210 VWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
            WY G + R +AQ  L+    G FLVR S   PG YVLS         ++I    + R +
Sbjct: 13  AWYFGPVLRPEAQNRLQGQKHGMFLVRDSSTCPGDYVLSVSENSKVSHYIITSLPNKRFK 72

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             DR F ++  L++++  + +           +  LI P P 
Sbjct: 73  IGDREFEHLPALLEFYKYHYL----------DTTTLIEPAPR 104


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score = 97.8 bits (242), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 12/107 (11%)

Query: 206 VVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +    WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I   + 
Sbjct: 8   LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASD 67

Query: 264 NRVRTRDRT-FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            ++     + F+ ++EL+ +H      +            L  P P 
Sbjct: 68  GKLYVSSESRFNTLAELVHHHSTVADGLI---------TTLHYPAPK 105


>UniRef50_B0X6G9 Corkscrew phosphatase n=4 Tax=Neoptera RepID=B0X6G9_CULQU
          Length = 109

 Score = 97.8 bits (242), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 30/105 (28%), Positives = 52/105 (49%), Gaps = 8/105 (7%)

Query: 209 KVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
           + W+H ++S  DA+ LL     +G FL R S   PG + LS R  + E  H+ + +N + 
Sbjct: 2   ERWFHPSVSGVDAEKLLLERGFDGSFLARLSSSNPGAFTLSVRRGK-EVTHIKIQNNGDF 60

Query: 266 VR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                   F+ +SEL+ Y++ NG  ++         + L +P+ C
Sbjct: 61  FDLYGGEKFATLSELVQYYMENGGQLK---EKNGQIIELKQPLIC 102


>UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic region of tyrosine kinase
           adaptor protein 2 n=1 Tax=Ciona intestinalis
           RepID=UPI000044C560
          Length = 413

 Score = 97.8 bits (242), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 23/107 (21%), Positives = 48/107 (44%), Gaps = 7/107 (6%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
           + +  + WY GN+ R DA+  L+     G+FLVR S+ + G Y +S +         +  
Sbjct: 309 DGIHSRDWYFGNMKRADAEQRLQDRADNGEFLVRGSETSSGDYSISMKMPGRIRHFKVNT 368

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             +       R F ++  L++++ +  +    E    +  + L +P+
Sbjct: 369 LPNGVFGIGQRKFDSMDALLEHYKSAPIYTSKE----QGKVYLSKPM 411


>UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform 2 n=1 Tax=Apis mellifera
            RepID=UPI0000DB713D
          Length = 1122

 Score = 97.8 bits (242), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 52/108 (48%), Gaps = 10/108 (9%)

Query: 206  VVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
            +  + WYHG+++R +A+A+L+   EG +LVR S+ T   Y LS ++A       I  +  
Sbjct: 1016 LERQGWYHGSITRIEAEAVLRLLREGSYLVRNSESTKQDYSLSLKSARGFMHMRIQKNEE 1075

Query: 264  -NRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
             N        + F +I E++ +   N + +R         + L+ PV 
Sbjct: 1076 LNAYILGQFSKPFDSIPEMVRHFSVNRLPIRGA-----EHMCLLHPVI 1118


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score = 97.8 bits (242), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 12/107 (11%)

Query: 206 VVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +    WYHG +SR  A+ LL +  +G FLVR S+ +PG   +S R     + + I   + 
Sbjct: 182 LEKHSWYHGPISRNAAEYLLSSGIDGSFLVRDSESSPGHRSISLRFDGRVYHYRISSGSD 241

Query: 264 NRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            +V  T +  FS I+EL+ +H           +       L  P   
Sbjct: 242 GKVFVTTESKFSTIAELVHHHCK---------QSDGLITTLRYPAAK 279


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score = 97.8 bits (242), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 32/136 (23%), Positives = 51/136 (37%), Gaps = 19/136 (13%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDH 238
           R +S+       SN  A   +  +  + WY G + R +A+  L       G FLVR S+ 
Sbjct: 121 RSKSTKQEGYIPSNYVAKLKS--IEAEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDSES 178

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDR 297
               + LS R  +    + I   +        R TF  + EL+D++              
Sbjct: 179 RRNDFSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVDHY---------GNEAD 229

Query: 298 ETSLNLIRP---VPCP 310
              +NL +P   V  P
Sbjct: 230 GLCVNLRKPCVQVEKP 245


>UniRef50_Q9JID9 SH2B adapter protein 2 n=13 Tax=Euteleostomi RepID=SH2B2_MOUSE
          Length = 621

 Score = 97.5 bits (241), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 50/276 (18%), Positives = 96/276 (34%), Gaps = 39/276 (14%)

Query: 58  VTAAREINPVVSRVIG-----------EVKKENFPVDINISSKMIKIIKQSRLIQRHPFS 106
               +   P VS  +            E+ +++    + + +    I++    +Q+H  S
Sbjct: 232 FVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKH--S 289

Query: 107 FFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHK----LIDVLTTAIN--VN 160
           + +         D+E   G           R      E +           TTA+   V 
Sbjct: 290 WVADIQGCVDPGDSEEDTGLSCARGGCLASRVASCSCELLTDADMPRPPETTTAVGAVVT 349

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP-----------TVTEDVVGK 209
               +A  +          P      +L     VS    P               ++   
Sbjct: 350 APHGRARDTVGES--LAHVPLETFLQTLESSGGVSENNNPGDEGAELDTDAEAELELSDY 407

Query: 210 VWYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNH 263
            W+HG LSR  A  L+     ++ G F++RQS+  PG+ VL+    + + KHL L L+ H
Sbjct: 408 PWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTF-NFQGKAKHLRLSLNGH 466

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
            +   +   F ++ +++ +   + + + S G    T
Sbjct: 467 GQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADIT 502


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score = 97.5 bits (241), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 35/123 (28%), Positives = 60/123 (48%), Gaps = 11/123 (8%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKTE----GDFLVRQSDHTPGKYVLSGRTAENEHKH 256
              + V  + W+ G ++R  A + L ++    G FLVR S+     YVLS RT EN  KH
Sbjct: 124 LARDSVESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKEN-AKH 182

Query: 257 LILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP--VPCPGSD 313
             +    ++        FS+I E+I+++ ++ +++   G         I+P  VP P +D
Sbjct: 183 FKIFQTGDQFYVDALFKFSSIVEVIEHYQSHPLSI---GDLLSEPCIRIKPENVPPPSTD 239

Query: 314 DIE 316
           + E
Sbjct: 240 EWE 242


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score = 97.5 bits (241), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 48/109 (44%), Gaps = 11/109 (10%)

Query: 205 DVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
            +    W+HG+++R++A+ LL  + +G FLVR+S + PG Y L          + +    
Sbjct: 473 KLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLE 532

Query: 263 HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
           +      +  F N+ +L+ ++         E         LI+ +P  G
Sbjct: 533 NKLTIDDEEYFENLGQLVAHY---------EADADGLCTQLIKCLPKLG 572


>UniRef50_UPI00015B496D PREDICTED: similar to conserved hypothetical protein n=3
            Tax=Coelomata RepID=UPI00015B496D
          Length = 1182

 Score = 97.1 bits (240), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 29/108 (26%), Positives = 52/108 (48%), Gaps = 10/108 (9%)

Query: 206  VVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
            +  + WYHG+++R +A+A+L+   EG +LVR S+ T   Y LS ++A       I  +  
Sbjct: 1076 LERQGWYHGSITRIEAEAVLRLLREGSYLVRNSESTKQDYSLSLKSARGFMHMRIQKNEE 1135

Query: 264  -NRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
             N        + F +I E++ +   N + +R         + L+ PV 
Sbjct: 1136 LNAYILGQFSKPFDSIPEMVRHFSINRLPIRGA-----EHMCLLHPVI 1178


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score = 97.1 bits (240), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 20/133 (15%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK----TEGDFLVRQSDH 238
           R R +  +     N  AP  T  +  + WY G++ R DA+ LL      +G FL+R+S++
Sbjct: 103 RSRKNGKKGYIPGNYVAPIQT--LEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSEN 160

Query: 239 TPGK----YVLSGRTAENEHKHLILLDNHNRVRTR-DRTFSNISELIDYHVNNGMAVRSE 293
             G+    + LS R  E    + I + +  +      + FS ++ELI+++      + S+
Sbjct: 161 KNGQVSNCFALSVRDKELIRHYRIKITDSGKYFISLSKEFSTLNELIEFYK-----ISSD 215

Query: 294 GRDRETSLNLIRP 306
           G      + L+ P
Sbjct: 216 G----LKIKLLEP 224


>UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor receptor-bound protein 2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A1C
          Length = 176

 Score = 97.1 bits (240), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 27/110 (24%), Positives = 48/110 (43%), Gaps = 2/110 (1%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKH 256
            P  T   +   W+   ++R++A+ LL  E  G FLVR+S+ + G Y LS +  E+    
Sbjct: 2   GPKHTYPEIAMAWFFPTITRKNAELLLMQERNGAFLVRRSESSEGLYSLSVKYNESVQHF 61

Query: 257 LILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
            IL D   +       F ++  L+DY+    +   ++   +        P
Sbjct: 62  RILQDTAGKFHLWIVKFPSLDALVDYYRTTSVTRENQVSTQSVEQWSRNP 111


>UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=Euteleostomi
           RepID=SHD_HUMAN
          Length = 340

 Score = 97.1 bits (240), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 29/106 (27%), Positives = 51/106 (48%), Gaps = 9/106 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +  + W+HG L+R DA++LL    EG +LVR S+  P    LS R+++            
Sbjct: 235 LEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTRE 294

Query: 264 NRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           N+V     +  F ++ EL+ ++ +  + V+         L L+ PV
Sbjct: 295 NQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA-----EHLALLYPV 335


>UniRef50_B5X4M4 SH2 domain-containing protein 4A n=2 Tax=Clupeocephala
           RepID=B5X4M4_SALSA
          Length = 430

 Score = 97.1 bits (240), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 48/210 (22%), Positives = 80/210 (38%), Gaps = 33/210 (15%)

Query: 127 IAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRS 186
           IAK      RR  V  +E     +  +T A   +           N   TV +  +  + 
Sbjct: 231 IAKQTRDDHRRQSVKALE--RGRVAAVTKAFGGDRPVLPPKPKPRN--LTVTSDTLNPKQ 286

Query: 187 SLHRQSFVSN--------------CRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGD 230
            L R    S+               RA    +      W+HG +SR++A+ LL     G 
Sbjct: 287 GLQRTLSTSSREHIIRWFQEEQLPFRAGFQKDQSRIASWFHGIISRQEAEDLLSEGEPGH 346

Query: 231 FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--FSNISELIDYHVNNGM 288
           FLVR S+   G YVLS R  ++E KH ++               F++++EL+++H    +
Sbjct: 347 FLVRVSERILG-YVLSYRC-KDEFKHFLIDATEGCYMLLGHQIRFTSLAELVEFHKGEPI 404

Query: 289 AVRSEGRDRETSLNLIRP--VPCPGSDDIE 316
            +    +       L++P      G D  +
Sbjct: 405 TMSGGEQ-------LLQPCGQRPSGVDYAD 427


>UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax=Amniota
           RepID=SHF_HUMAN
          Length = 480

 Score = 97.1 bits (240), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 29/157 (18%), Positives = 67/157 (42%), Gaps = 16/157 (10%)

Query: 162 FDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTED-------VVGKVWYHG 214
           F+    +  S         P R  +   + +   +    +   +       +  +VWYHG
Sbjct: 324 FEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHG 383

Query: 215 NLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT 272
            +SR DA+ LL+   E  +LVR S+ +   + LS ++++      +    +N+      +
Sbjct: 384 AISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKNNKYVLGQNS 443

Query: 273 --FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             FS++ E++ ++ +  + ++         ++L+ PV
Sbjct: 444 PPFSSVPEIVHHYASRKLPIKGA-----EHMSLLYPV 475


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score = 97.1 bits (240), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 23/101 (22%), Positives = 44/101 (43%), Gaps = 2/101 (1%)

Query: 192 SFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRT 249
           ++V           +    W+HG ++RE A+ LL     G FLVR+S + PG Y L    
Sbjct: 63  NYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSC 122

Query: 250 AENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
                 + I+          +  F N+ +L++++ ++   +
Sbjct: 123 DGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGL 163


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score = 97.1 bits (240), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 31/115 (26%), Positives = 49/115 (42%), Gaps = 12/115 (10%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQS 236
             R  ++       SN  AP  +  +  + WY G L R+DA+  L       G FL+R+S
Sbjct: 121 EARSLTTGETGYIPSNYVAPVDS--IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRES 178

Query: 237 DHTPGKYVLSGRTAE----NEHKHLILL--DNHNRVRTRDRTFSNISELIDYHVN 285
           + T G Y LS R  +    +  KH  +   DN     T    F  + +L+ ++  
Sbjct: 179 ETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSE 233


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score = 96.7 bits (239), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 25/109 (22%), Positives = 48/109 (44%), Gaps = 11/109 (10%)

Query: 205 DVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
            +    W+HG+++R++A+ LL  + +G FLVR+S + PG Y L          + +    
Sbjct: 678 KLNAMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLE 737

Query: 263 HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
           +      +  F N+ +L+ ++         E         LI+ +P  G
Sbjct: 738 NKLTIDDEEYFENLGQLVAHY---------EADADGLCTQLIKCLPKLG 777


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score = 96.7 bits (239), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 33/111 (29%), Positives = 50/111 (45%), Gaps = 5/111 (4%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHL 257
                   + WY G +SR +AQ+ L+    +G FLVR+S+ + G Y LS         + 
Sbjct: 248 VAKPGFESEPWYVGKMSRVEAQSKLQIFNLDGTFLVRESETSAGSYTLSVYFNGQPRNYR 307

Query: 258 ILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
           I  D +    T       I ELIDYH  NG  + +  R ++ + +   P P
Sbjct: 308 IQHDGNEYYITTRHRQKTIKELIDYHKLNGGGLCT--RLKKPACDDEAPTP 356


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score = 96.3 bits (238), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 33/117 (28%), Positives = 54/117 (46%), Gaps = 12/117 (10%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDH 238
              ++  R     N  A +  E    + W+  N+SR +A   L     T+G FLVR+S+ 
Sbjct: 91  ESLTTGQRGYIPYNFIAMSTME---TEAWFFKNISRNEATRRLMAPGNTQGSFLVRESET 147

Query: 239 TPGKYVLSGRTAENE---HKHLILL--DNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           TPG Y LS R  +N     KH  +   DN     T   +F+++ EL+ ++  +   +
Sbjct: 148 TPGSYSLSMRDFDNNGDGVKHYRIRNMDNGGFYITTKISFNSLKELVQHYSRDSDGL 204


>UniRef50_UPI00019266B8 PREDICTED: similar to Bam32 n=1 Tax=Hydra magnipapillata
           RepID=UPI00019266B8
          Length = 237

 Score = 96.3 bits (238), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 32/115 (27%), Positives = 48/115 (41%), Gaps = 8/115 (6%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
           + + V    W+H NL R  A+ALL     +G +L+R   +    YVLS R A N  KH  
Sbjct: 1   MEDRVEDLGWFHSNLDRHQAEALLLHNGQDGSYLLRICTNNENSYVLSCRCA-NSVKHFQ 59

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           +  +    R     F   SEL+ +  N  +     G +      L  P P   ++
Sbjct: 60  ISYDGKYYRFGMAIFETFSELVKHFENQPLL----GGESGVLTLLKYPYPRRVNE 110


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score = 95.9 bits (237), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 34/170 (20%), Positives = 61/170 (35%), Gaps = 25/170 (14%)

Query: 153 LTTAINVNTFDAQANASTSNDGFTVPAPPM------RHRSSLHRQSFVSNCRAPTVTEDV 206
           +  A+  N        S   D + +           RH  +           AP  +  +
Sbjct: 279 VVVALYDNDPRGDMELSMRKDDYLLELRSDGAWVQCRHLMTNEEGFVPGTFVAPYKS--L 336

Query: 207 VGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
             + W+ G ++R  A+ LL    +  G FL+R+S+ TPG + LS +  EN  +H  +   
Sbjct: 337 EAEPWFFGPITRAKAEKLLGVPARKHGCFLIRESESTPGTFSLSMKDGEN-VRHFRVKKV 395

Query: 263 HNRVRTRD---RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
              ++ +        ++  LI YH  +   +            L  P P 
Sbjct: 396 AGGIKLQGSPSSPHKDLPSLIKYHKRHRGGLT---------TTLKVPCPR 436


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score = 95.9 bits (237), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 36/140 (25%), Positives = 55/140 (39%), Gaps = 10/140 (7%)

Query: 182 MRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG----DFLVRQSD 237
                ++ +     N  A    E V  + W+ G +SR +A   L+ EG     FL+R S+
Sbjct: 51  DEAGGAVAQGYVPHNYLA--ERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSE 108

Query: 238 HTPGKYVLSGRTAENEHKHLILLDNHNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRD 296
                YVLS R  +    + I      R+      +F ++ EL++YH    +   S G  
Sbjct: 109 KPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSL---SHGLR 165

Query: 297 RETSLNLIRPVPCPGSDDIE 316
                    P P P  DD E
Sbjct: 166 LAAPCRKHEPEPLPHWDDWE 185


>UniRef50_UPI000194DC0C PREDICTED: similar to nuclear localized factor 3 n=3
           Tax=Euteleostomi RepID=UPI000194DC0C
          Length = 686

 Score = 95.9 bits (237), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 30/183 (16%), Positives = 63/183 (34%), Gaps = 24/183 (13%)

Query: 46  SECIQHVAATV----GVTAAREINPVVSRVIGE--VKKENFPVDINISSKMIKII--KQS 97
            E I  +   V    G+   +  N  +  ++G+  +      + +NIS   + ++     
Sbjct: 38  GEAINRLYEAVPGVKGIWKKKAPNKALFSILGKSNLHFAGMSIAVNISVDGLNLMIPTTR 97

Query: 98  RLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAI 157
           ++I  H     SF + G    DT     Y+AK+     R CH++  E    L   + + +
Sbjct: 98  QIIANHHMQSISFASGGDM--DTTDYVAYVAKDPI-NQRACHIL--ECCEGLAQSVISTV 152

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
               F+ +      +    V  P      +L  +             D      Y+ ++ 
Sbjct: 153 G-QAFELRFKQYLHSPPKVVVPPE----RALPAEESAWGEDEEAAEHD------YYNSIP 201

Query: 218 RED 220
            ++
Sbjct: 202 GKE 204


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186ED21
          Length = 751

 Score = 95.5 bits (236), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 5/81 (6%)

Query: 211 WYHGNLSREDAQAL---LKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+HG LSR+DA+ L   L +EG FLVR+S  +PG +VL+     +   + IL    +   
Sbjct: 9   WFHGKLSRDDAEKLIQDLNSEGGFLVRESFASPGDFVLTLLHNGDIVHYQILRHGEDAFF 68

Query: 268 --TRDRTFSNISELIDYHVNN 286
               +  F  +  LI+YH  N
Sbjct: 69  SIDNEHIFHGLETLINYHQEN 89



 Score = 85.9 bits (211), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 41/214 (19%), Positives = 72/214 (33%), Gaps = 24/214 (11%)

Query: 91  IKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRR--------CHVVF 142
           IK+I+    I     + ++      +      +   I K +     R         H   
Sbjct: 166 IKLIETGANINCRDTAGYTPLHYACQSNHLTTIRLLIQKGEAQVQSRNANTGWVPLHEAA 225

Query: 143 IEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTV 202
              + ++I +L         +A A+  T         P M  +    +       +    
Sbjct: 226 WRGLSEVIQLLLG------LNAPAHPRTLE----GETPLMLAQRKGFQDCVEILRKYKAP 275

Query: 203 TEDVVGKVWYHGNLSREDAQALLK----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
              +    WYHG L R++A  LLK     EG +LVR S    G YVL+    +      I
Sbjct: 276 KPVLSKYNWYHGTLDRKEAVELLKEYGNKEGSYLVRYSHKNGGVYVLTMIVNDRSFHFQI 335

Query: 259 LLDNHNRVRTRDRTFSNISELIDYH--VNNGMAV 290
             +N            ++  +IDY+  + +G+  
Sbjct: 336 KNENGYYFIDDGPLLESLEHVIDYYSRMQDGLPT 369


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score = 95.5 bits (236), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 36/127 (28%), Positives = 50/127 (39%), Gaps = 19/127 (14%)

Query: 190 RQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLS 246
                SN        ++    WYH N++R  A+ LL+    EG F+VR S H  G Y +S
Sbjct: 129 EGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHL-GSYTIS 187

Query: 247 G----RTAENEHKHLILLDNHNR--VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
                R+ E   KH  +  N +          F +I ELI YH +N   +          
Sbjct: 188 VFMGARSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLM--------- 238

Query: 301 LNLIRPV 307
             L  PV
Sbjct: 239 TRLRYPV 245


>UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus (Silurana)
           tropicalis RepID=B4F705_XENTR
          Length = 458

 Score = 95.5 bits (236), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 30/160 (18%), Positives = 61/160 (38%), Gaps = 21/160 (13%)

Query: 164 AQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTE------------DVVGKVW 211
           A    S    G              H    +   + P+V               +  + W
Sbjct: 299 AAQFDSADKTGMAAAKEDKPRHMHRHSAGNLKAIKHPSVEHCISVGERIDPSLPLESQFW 358

Query: 212 YHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTR 269
           YHG +SR DA++LL+   E  +LVR S+     + LS ++ +      +     N+    
Sbjct: 359 YHGAISRADAESLLRLCKEASYLVRNSETNKIDFSLSLKSIQGFMHMKLSRTKENKYVLG 418

Query: 270 DRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             +  F+++ E+I ++ +  + ++         ++L+ PV
Sbjct: 419 HNSPPFNSVPEIIHHYASQKLPIKGA-----EHMSLLYPV 453


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score = 95.5 bits (236), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 8/102 (7%)

Query: 211 WYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           WYHGNL+R  A+ALL +   +G +L+R S+ T G Y LS R A++  KH  +       +
Sbjct: 35  WYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVR-AKDSVKHFHVEYTGYSFK 93

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                FS++ + + +  N  +     G +  T + L  P P 
Sbjct: 94  FGFNEFSSLKDFVKHFANQPLI----GSETGTLMVLKHPYPR 131


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score = 95.5 bits (236), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 27/113 (23%), Positives = 43/113 (38%), Gaps = 3/113 (2%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTP 240
            ++   ++     C    +   +    W HG +SR  A  LLK    +G +LVR+S   P
Sbjct: 47  AQNLNTKKKGWIPCSLVALDGSLELFDWCHGAISRNGADYLLKQHGIDGMYLVRESQSQP 106

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           G+Y L          + I   +      +   F  I ELI +H      + S 
Sbjct: 107 GQYTLDVWKEGKSVHYRITKGDEGYFFRQGVCFPTIPELIQHHQTRSDGLCSS 159


>UniRef50_Q6PE32 Zgc:65942 n=1 Tax=Danio rerio RepID=Q6PE32_DANRE
          Length = 249

 Score = 95.5 bits (236), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 26/107 (24%), Positives = 50/107 (46%), Gaps = 7/107 (6%)

Query: 211 WYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WY  N SR+ AQ  L  +  G F++R S  +PG + +S R   +     ++ D   R   
Sbjct: 58  WYKENTSRQSAQDELMCQPIGAFIIRGSQSSPGDFSISVRHENDVQHFKVMRDRQGRYYL 117

Query: 269 RDRTFSNISELIDYHVNNGMAVRSE-----GRDRETSLNLIRPVPCP 310
               F+++++L+DY+ +N ++ +S       +   +     +P   P
Sbjct: 118 WSEMFTSLNKLVDYYTHNSISKQSRVFLLTDQRSSSDFLHRKPTEAP 164


>UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=Euteleostomi
           RepID=SHD_MOUSE
          Length = 343

 Score = 95.1 bits (235), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 29/106 (27%), Positives = 48/106 (45%), Gaps = 9/106 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +  + W+HG LSR +A+ LL    EG +LVR S+      +LS R+ +            
Sbjct: 220 LEKQPWFHGPLSRAEAENLLSLCKEGSYLVRLSETRAQDCILSLRSNQGSMHLKFARTRE 279

Query: 264 NRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           N+V     +  F +I EL+ ++    + V+         L L+ PV
Sbjct: 280 NQVVLGQHSGPFPSIPELVLHYSARPLPVQGA-----EHLALLYPV 320


>UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=9 Tax=Euteleostomi
           RepID=A2AQ87_MOUSE
          Length = 446

 Score = 95.1 bits (235), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 27/145 (18%), Positives = 59/145 (40%), Gaps = 12/145 (8%)

Query: 168 ASTSNDGFTVPAPPMRHRSSLHRQSFV-SNCRAPTVTEDVVGKVWYHGNLSREDAQALLK 226
                        P   +      S        P +   +  +VWYHG +SR DA+ LL+
Sbjct: 304 EKGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALP--LENQVWYHGAISRTDAENLLR 361

Query: 227 --TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--FSNISELIDY 282
              E  +LVR S+ +   + LS ++++      +     ++      +  FS++ E++ +
Sbjct: 362 LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHH 421

Query: 283 HVNNGMAVRSEGRDRETSLNLIRPV 307
           + +  + ++         ++L+ PV
Sbjct: 422 YASRKLPIKGA-----EHMSLLYPV 441


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score = 95.1 bits (235), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 27/93 (29%), Positives = 43/93 (46%), Gaps = 5/93 (5%)

Query: 194 VSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAE 251
            SN   P  + ++    WYHG +SR  A+ LL +   G FLVR S+   G   +S R   
Sbjct: 72  PSNYITPATSLNM--HTWYHGAVSRAAAEYLLSSGINGSFLVRDSESCRGHLSVSVRFNA 129

Query: 252 NEHKHLILLDNHNRVRTR-DRTFSNISELIDYH 283
           + + + I +D         +  F  + EL+ +H
Sbjct: 130 SVYHYRINVDTAGLFYISPEHRFQTLPELVHHH 162


>UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=O01325_CAEEL
          Length = 474

 Score = 94.8 bits (234), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 32/149 (21%), Positives = 66/149 (44%), Gaps = 3/149 (2%)

Query: 148 KLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVV 207
           K  D  ++     +       S  N   +  +  ++    L  +       +      + 
Sbjct: 29  KATDETSSDGASTSLSKSVEESAPNKDKSNSS-LVKSHHVLKIKLKKITNWSGCSGALLD 87

Query: 208 GKVWYHGNLSREDAQALLKTEGDFLVRQSD-HTPGK-YVLSGRTAENEHKHLILLDNHNR 265
            + +YHG +SRE+++ L++++G+FL+R+++    G+  VLS    E  H  ++   N+  
Sbjct: 88  DEPFYHGYMSREESEKLVRSQGEFLLRKTELTKRGEVVVLSVFWDEGVHHLVVEKANNGL 147

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEG 294
              ++  F NIS+L+ YH     +V   G
Sbjct: 148 YYLKEFCFENISDLVRYHHQTRASVYKSG 176


>UniRef50_A7RZ47 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7RZ47_NEMVE
          Length = 948

 Score = 94.4 bits (233), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 28/102 (27%), Positives = 47/102 (46%), Gaps = 8/102 (7%)

Query: 198 RAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL 257
           +  +    +    W+HG ++ E A+ L++  G+FLVR+    PG Y ++ R  E E  HL
Sbjct: 45  KGDSAARQLEKSPWFHGKITAEYAEMLMRGAGEFLVREDPAMPGMYFIAVRNKEQETLHL 104

Query: 258 ILLDNH--------NRVRTRDRTFSNISELIDYHVNNGMAVR 291
            +   +         RV   D  F  I ELI ++++    V 
Sbjct: 105 AITKVNHSKGTRIKYRVEDSDYMFDGIPELIQFYISERRPVS 146


>UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax=Euteleostomi
           RepID=SHF_MOUSE
          Length = 238

 Score = 94.4 bits (233), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 27/145 (18%), Positives = 59/145 (40%), Gaps = 12/145 (8%)

Query: 168 ASTSNDGFTVPAPPMRHRSSLHRQSFV-SNCRAPTVTEDVVGKVWYHGNLSREDAQALLK 226
                        P   +      S        P +   +  +VWYHG +SR DA+ LL+
Sbjct: 96  EKGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALP--LENQVWYHGAISRTDAENLLR 153

Query: 227 --TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--FSNISELIDY 282
              E  +LVR S+ +   + LS ++++      +     ++      +  FS++ E++ +
Sbjct: 154 LCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQNSPPFSSVPEIVHH 213

Query: 283 HVNNGMAVRSEGRDRETSLNLIRPV 307
           + +  + ++         ++L+ PV
Sbjct: 214 YASRKLPIKGA-----EHMSLLYPV 233


>UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UZG2_MONBE
          Length = 1021

 Score = 94.4 bits (233), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 38/185 (20%), Positives = 80/185 (43%), Gaps = 22/185 (11%)

Query: 125 GYIAKNKDGTDRRCHVVFIEDVHKLIDVL--------TTAINVNTFDAQANAS---TSND 173
           G++A+      +R   +++++     + +            + +  D + +AS       
Sbjct: 724 GFLARKFRANMKRKMQMYLQETGVFFETVRRNGATYGARVASNDAEDMRRHASGIQPRRP 783

Query: 174 GFTVPAPPMRHRSSLHRQSFVS---NCRAPT-VTEDVVG--KVWYHGNLSREDAQALLKT 227
             +VPA P +    L R + ++       P    +D  G    W+HG +SR +A+ LL+ 
Sbjct: 784 PPSVPAGPRKSEQELKRDASIAWWKEKEEPRGAGKDSYGGFMPWFHGLISRREAEELLRP 843

Query: 228 E--GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--FSNISELIDYH 283
              G FLVR S++  G Y LS R ++    +++  +   +      +    +++ELI++ 
Sbjct: 844 RYIGCFLVRVSENRFG-YTLSYRVSDRCRHYMVEQNTQGQYALVGVSKIADSLNELIEWF 902

Query: 284 VNNGM 288
             N +
Sbjct: 903 QRNPI 907


>UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE
          Length = 250

 Score = 94.0 bits (232), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 28/108 (25%), Positives = 49/108 (45%), Gaps = 8/108 (7%)

Query: 205 DVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
           +V    WYHG+LSR  A+ALL     +G +L+R S    G+Y LS +  ++  KH  +  
Sbjct: 8   EVEQLDWYHGDLSRHMAEALLMANAEDGSYLLRSSATRVGEYSLSVKC-KDSVKHFQIGW 66

Query: 262 NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           +  + +     F ++ E +++  N  +     G +      L  P   
Sbjct: 67  DGKQYQFGMGVFQSLQEFVEHFANQPLI----GGESGILTALRHPYSR 110


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score = 94.0 bits (232), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 27/103 (26%), Positives = 46/103 (44%), Gaps = 12/103 (11%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WYHG +SR+  + LL++   G FLVR S+  PG+  ++ R     + + I  D+      
Sbjct: 241 WYHGAVSRQAGEHLLRSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGLFYI 300

Query: 269 -RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
                F  + +LI++H  +   +            L+  VP P
Sbjct: 301 TEAHRFPTVVQLIEHHSRSADGLV---------CPLLYSVPKP 334


>UniRef50_Q9VXH3 Small wing n=17 Tax=Drosophila RepID=Q9VXH3_DROME
          Length = 1236

 Score = 94.0 bits (232), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 36/115 (31%), Positives = 49/115 (42%), Gaps = 19/115 (16%)

Query: 208 GKVWYHGNL--SREDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
           G+ W+HG L   R++A  LLK      +G FLVR+S    G Y LS     N   H  + 
Sbjct: 586 GENWFHGKLEGGRKEADDLLKKYKHFGDGTFLVRESATFVGDYSLSF-WRRNRPNHCRIK 644

Query: 261 DNHN-----RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
             H           +  F ++  LI Y+  N +      R  E S+ L  PVP P
Sbjct: 645 LKHENGSIKYYLVENFVFDSLYSLIVYYRKNML------RSSEFSIILKEPVPQP 693



 Score = 79.7 bits (195), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 30/132 (22%), Positives = 50/132 (37%), Gaps = 6/132 (4%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE--GDFLVRQSDHTPGK 242
           RSS            P   ED   + W+H N ++E A+  L     G FLVR S  +   
Sbjct: 678 RSSEFSIILKEPVPQPKKHED---QEWFHPNTTKEQAEQGLYRLEIGSFLVRPSVQSINA 734

Query: 243 YVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLN 302
           +V+S  T   + KH  ++            F ++  LI+Y+  N +    +     +   
Sbjct: 735 FVISF-TINRKIKHCRIMQEGRLYGIDTMNFESLVSLINYYTRNPLYRNVKLSHPVSQEL 793

Query: 303 LIRPVPCPGSDD 314
           L + +      D
Sbjct: 794 LRQALAEAAQGD 805


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score = 94.0 bits (232), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 27/110 (24%), Positives = 48/110 (43%), Gaps = 15/110 (13%)

Query: 206 VVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAEN---EHKHLILL 260
           +    W+ G ++RE A+ LL  +  G FLVR+S + PG Y L   + +N      + ++ 
Sbjct: 87  LHEMPWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVIS 146

Query: 261 DNHNRVRTRDRT-FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            + N+V   +   F  + ELI ++         E         L +P+  
Sbjct: 147 TSDNQVTVDEEAFFPTLIELIKHY---------EKDADGLCTMLKKPLKK 187


>UniRef50_UPI00017925DF PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Acyrthosiphon
           pisum RepID=UPI00017925DF
          Length = 555

 Score = 94.0 bits (232), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 35/136 (25%), Positives = 59/136 (43%), Gaps = 14/136 (10%)

Query: 175 FTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFL 232
              P  P     ++   +FV +     V+  +  + WYHG ++R +A+  L  + EG +L
Sbjct: 424 KNQPNRPTLSLCNIKPLNFVEDID---VSLPLDQQCWYHGPMNRLEAEKALHGQKEGTYL 480

Query: 233 VRQSDHTPGKYVLSGRTAENEHKHLILLDNH-NRVRTRDRTFSNISELIDYHVNNGMAVR 291
           VR      G Y LS ++A+      I      N +   DR F  I +LI ++  N +  +
Sbjct: 481 VR---GNKGSYALSIKSAKGFIHMRITQSEERNYLGQSDRPFETIPDLIKHYTLNKLPAK 537

Query: 292 SEGRDRETSLNLIRPV 307
                    + LIRP+
Sbjct: 538 GA-----EHVGLIRPL 548


>UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n=1 Tax=Taeniopygia guttata
           RepID=UPI000194DE57
          Length = 699

 Score = 93.6 bits (231), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 39/162 (24%), Positives = 64/162 (39%), Gaps = 11/162 (6%)

Query: 137 RCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVP------APPMRHRSSLHR 190
           RC     +    ++D     +    FD   N S               A   + +     
Sbjct: 510 RCIKPNNQKEPGVLDNQVVLLQSTPFDNFLNPSVPPPVLGTEEQTGEEAKVRKLKRGATL 569

Query: 191 QSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGR 248
           + F        + +D     W HG +SR +A+ LL  K  G FLVR S   PG Y+L+ R
Sbjct: 570 RWFTETQAQKVMQDDGAFPSWLHGMISRREAENLLIDKPLGSFLVRISQSRPG-YILTYR 628

Query: 249 TAENEHKHLILLDNHNRVRT--RDRTFSNISELIDYHVNNGM 288
                  ++I +  + R      DR  ++++EL+ YH + G+
Sbjct: 629 GEGRCRHYMIQVQPNARYVILGEDRAHASLTELVRYHQSVGI 670


>UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000586DB6
          Length = 177

 Score = 93.6 bits (231), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 23/77 (29%), Positives = 45/77 (58%), Gaps = 2/77 (2%)

Query: 215 NLSREDAQALLKTEGD--FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT 272
            ++R+ A+ LLK +GD  FL+R+S+ TPG Y LS +  +      +L D   +       
Sbjct: 27  KVTRDGAEELLKNDGDGAFLIRESEGTPGDYSLSVKFVDGVQHFKVLRDGAGKYFLWVVK 86

Query: 273 FSNISELIDYHVNNGMA 289
           F+++++L++YH  + ++
Sbjct: 87  FNSLNQLVEYHRTSSVS 103


>UniRef50_Q18865 Putative uncharacterized protein n=6 Tax=Caenorhabditis
           RepID=Q18865_CAEEL
          Length = 431

 Score = 93.6 bits (231), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 30/115 (26%), Positives = 56/115 (48%), Gaps = 6/115 (5%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAEN-EHKHLI 258
            +D++ + +YHG L RED Q +L   G FL+R S+   G   ++VLS    +N    H +
Sbjct: 3   DKDLLHQKYYHGLLPREDIQEMLNKPGQFLLRTSEPVKGEKRQFVLSVVGEKNTSANHFV 62

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           + +  ++V      F  I EL++++V+   +  +  +D    + L   V     +
Sbjct: 63  VREADHKVYVDKIGFPTIIELVNHYVSTKESFST--KDGTVKVVLKHAVERQKWE 115


>UniRef50_UPI0000D9EE2E PREDICTED: similar to src homology 2 domain-containing transforming
           protein D n=1 Tax=Macaca mulatta RepID=UPI0000D9EE2E
          Length = 221

 Score = 93.2 bits (230), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 29/101 (28%), Positives = 50/101 (49%), Gaps = 9/101 (8%)

Query: 211 WYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           W+HG L+R DA++LL    EG +LVR S+ +P    LS R+++            N+V  
Sbjct: 121 WFHGPLNRADAESLLSLCKEGSYLVRLSETSPQDCSLSLRSSQGFLHLKFARTRENQVVL 180

Query: 269 RDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
              +  F ++ EL+ ++ +  + V+         L L+ PV
Sbjct: 181 GQHSGPFPSVPELVLHYSSRPLPVQGA-----EHLALLYPV 216


>UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 Tax=Ailuropoda
           melanoleuca RepID=D2GVU7_AILME
          Length = 574

 Score = 93.2 bits (230), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 36/157 (22%), Positives = 63/157 (40%), Gaps = 11/157 (7%)

Query: 168 ASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTED---VVGKVWYHGNLSREDAQAL 224
            S    G      P     SL++ +       P   +    +    W+HG +SR  A  L
Sbjct: 325 PSALEPGTGTSNSPGGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQL 384

Query: 225 LK-----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHNRVRTRDRTFSNISE 278
           ++       G FLVRQS+   G+YVL+    +   KHL L L    + R +   F ++ +
Sbjct: 385 VQLQGPDAHGVFLVRQSETRRGEYVLTF-NFQGIAKHLRLSLTERGQCRVQHLHFPSVVD 443

Query: 279 LIDYHVNNGMAVR-SEGRDRETSLNLIRPVPCPGSDD 314
           ++ +   + + +      D   S  ++     PGS +
Sbjct: 444 MLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSSN 480


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score = 93.2 bits (230), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 24/113 (21%), Positives = 44/113 (38%), Gaps = 7/113 (6%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDH 238
           R + +       SN  A   +  +  + WY   + R +A+  L       G FL+R S+ 
Sbjct: 104 RSKKTRSEGYIPSNYVAKLKS--IEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDSES 161

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAV 290
               Y LS R  +    + I   +        R TF  + EL++++  +   +
Sbjct: 162 RHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGL 214


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score = 93.2 bits (230), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 24/106 (22%), Positives = 41/106 (38%), Gaps = 11/106 (10%)

Query: 206 VVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +  + +YHG + R  A+  L     G FLVR+S    G++ +S R       + I   + 
Sbjct: 174 LDSEPYYHGRIPRTTAEFFLSNGINGSFLVRESQSNAGEHTISLRCDGKVFHYRISRTDK 233

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                 DR FS + +L+ ++      +            L   VP 
Sbjct: 234 GVFIAADRVFSTVQDLVKFYHQQSDGLVHP---------LRHAVPK 270


>UniRef50_A8P4D4 Protein kinase domain containing protein n=2 Tax=Brugia malayi
           RepID=A8P4D4_BRUMA
          Length = 428

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 32/116 (27%), Positives = 52/116 (44%), Gaps = 11/116 (9%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGK-----YVLSGRTAENEHKHLIL 259
           ++  + +YHG L RED   LL  EGDFLVR S+  P +       +         +H+++
Sbjct: 5   NLEDENYYHGLLPREDLPHLLINEGDFLVRSSETAPNQPRQVIISILVEKRGAILRHIVV 64

Query: 260 LDN-HNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
             N + +  T  R +F ++ ELI ++   G  V S          L R +  P  +
Sbjct: 65  QQNAYGKYVTDARASFDSVPELIQFYQKCGEPVLS----TVPKAVLKRAITRPPWE 116


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 15/105 (14%)

Query: 211 WYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAEN---EHKHLILLDNHNR 265
           W+ G ++RE A+ LL  +  G FLVR+S + PG Y L   + +N      + ++  N NR
Sbjct: 32  WFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRVISTNDNR 91

Query: 266 VRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           V    D  F N+ ELI ++         E         L +P+  
Sbjct: 92  VTVDEDAFFPNLIELIKHY---------ERDADGLCTMLKKPLKK 127


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 30/108 (27%), Positives = 53/108 (49%), Gaps = 10/108 (9%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGK 242
           ++S+ R+   +N + P        K+WYHGN++RE  + +L  + +G FLVR S + PG 
Sbjct: 28  QTSVDRRYVANNEQHP--------KLWYHGNITREHTEKILSGQADGTFLVRDSTNFPGD 79

Query: 243 YVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           Y L          + I   N       + TF N+++LI ++  +   +
Sbjct: 80  YTLCMAFNGKVEHYRIYQLNGILTCDHEETFDNLTQLIAHYKRDADGL 127


>UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194E163
          Length = 312

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 22/101 (21%), Positives = 50/101 (49%), Gaps = 2/101 (1%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEG--DFLVRQSDHTPGKYVLSGRTAENEHKHL 257
           P    D     W+   +SR +A+ LL ++G   F+VR S ++ G + +S R  ++     
Sbjct: 62  PKNFIDFHVPHWFDEKISRHEAENLLMSKGVGCFVVRASQNSHGDFSISVRHEDDVQHFK 121

Query: 258 ILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
           ++ D+          F ++++L+DY+  + ++ + +   R+
Sbjct: 122 VMRDSKGSYYLWTEKFHSLNKLVDYYKTSSISRQKQIFLRD 162


>UniRef50_UPI00016E9A01 UPI00016E9A01 related cluster n=3 Tax=Tetraodontidae
           RepID=UPI00016E9A01
          Length = 580

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 41/166 (24%), Positives = 68/166 (40%), Gaps = 18/166 (10%)

Query: 151 DVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP---TVTEDVV 207
           D   ++      +   N S   D   +P+PP     S  R S   + + P    + E VV
Sbjct: 295 DQQVSSWTTEIKECINNRSGGADLEPLPSPPDVSAPSSQRGSTELSSQGPAPLPMPEQVV 354

Query: 208 GK--------VWYHGNLSREDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENEH 254
            K         W+HG +SR  A  L+++      G FLVRQS+   G YVL+    + + 
Sbjct: 355 QKTDHFLFSYPWFHGPISRVKAAYLVQSSGPEGHGVFLVRQSETRRGDYVLTF-NYQGKA 413

Query: 255 KHLIL-LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
           KHL L L    + R +   F ++ +++ +     + +        T
Sbjct: 414 KHLRLSLTEWGQCRVQHLRFPSVMDMLSHFRLFPIPLECGAAGAVT 459


>UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistosoma
           RepID=Q5BXT3_SCHJA
          Length = 190

 Score = 92.8 bits (229), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 27/103 (26%), Positives = 46/103 (44%), Gaps = 12/103 (11%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WYHG +SR+  + LL++   G FLVR S+  PG+  ++ R     + + I  D+      
Sbjct: 78  WYHGAVSRQAGEHLLRSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGLFYI 137

Query: 269 -RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
                F  + +LI++H  +   +            L+  VP P
Sbjct: 138 TEAHRFPTVVQLIEHHSRSADGLV---------CPLLYSVPKP 171


>UniRef50_A7SCW1 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SCW1_NEMVE
          Length = 275

 Score = 92.4 bits (228), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 25/79 (31%), Positives = 41/79 (51%), Gaps = 3/79 (3%)

Query: 210 VWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
            WYHG L R + + +L  K  G +LVR S   PG YVLS  +   +  H I+ +      
Sbjct: 8   PWYHGVLKRVETEGILNGKPPGVWLVRDSTTIPGDYVLSV-SESGKVSHYIINNKGTMYT 66

Query: 268 TRDRTFSNISELIDYHVNN 286
             D+TF ++  +I+++  +
Sbjct: 67  IGDQTFPDLPSIIEFYKKH 85


>UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax=Euteleostomi
           RepID=SHB_HUMAN
          Length = 509

 Score = 92.4 bits (228), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 29/106 (27%), Positives = 51/106 (48%), Gaps = 10/106 (9%)

Query: 206 VVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +  ++WYHG +SR DA+ LL+   E  +LVR S  +   Y LS R+ +    H+ L    
Sbjct: 405 LEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQG-FMHMKLAKTK 463

Query: 264 NRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
            +      +  F ++ E+I Y+    + ++         L+L+ PV
Sbjct: 464 EKYVLGQNSPPFDSVPEVIHYYTTRKLPIKGA-----EHLSLLYPV 504


>UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
           n=83 Tax=Eumetazoa RepID=PLCG1_HUMAN
          Length = 1290

 Score = 92.4 bits (228), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 28/104 (26%), Positives = 48/104 (46%), Gaps = 14/104 (13%)

Query: 207 VGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
             K WYH +L+R  A+ +L     +G FLVR+  + P  Y +S R AE + KH  +    
Sbjct: 664 ESKEWYHASLTRAQAEHMLMRVPRDGAFLVRK-RNEPNSYAISFR-AEGKIKHCRVQQEG 721

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             V   +  F ++ +LI Y+  + +  +         + L  P+
Sbjct: 722 QTVMLGNSEFDSLVDLISYYEKHPLYRK---------MKLRYPI 756



 Score = 92.1 bits (227), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 31/145 (21%), Positives = 54/145 (37%), Gaps = 26/145 (17%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVG-KVWYHGNLS-----REDAQALLKT--------E 228
              SS          +  + + ++   + W+HG L      R  A+ LL          +
Sbjct: 521 EETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPD 580

Query: 229 GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN-----RVRTRDRTFSNISELIDYH 283
           G FLVR+S+   G Y LS      + +H  +    +        T +  F ++ +LI ++
Sbjct: 581 GSFLVRESETFVGDYTLSF-WRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHY 639

Query: 284 VNNGMAVRSEGRDRETSLNLIRPVP 308
               +      R  E  + L  PVP
Sbjct: 640 QQVPL------RCNEFEMRLSEPVP 658


>UniRef50_A8Q5B5 Putative uncharacterized protein n=1 Tax=Brugia malayi
           RepID=A8Q5B5_BRUMA
          Length = 1138

 Score = 92.4 bits (228), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 8/115 (6%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPG-KYVLSGRTAENEHKHLILLD 261
            +++  + WYHG LSRED + LL   GDFLVR +D+    + VLS    E      I + 
Sbjct: 715 RKELEDQHWYHGLLSREDIEKLLVKNGDFLVRVTDNQGVHQIVLSIHVGERNIHLTIAVT 774

Query: 262 NHNRVRT----RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGS 312
                +     R   F +I +L+ Y+  + + ++         + L   VP P  
Sbjct: 775 EDGHFQLSVLRRGPRFPSIYDLVQYYKMHKIKIKDASGKD---IRLGDGVPKPKW 826


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score = 92.4 bits (228), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 31/131 (23%), Positives = 50/131 (38%), Gaps = 13/131 (9%)

Query: 186 SSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPG 241
           S   +    SN  A      +  + W+ G + R DA+  L       G FL+R+S+   G
Sbjct: 93  SQQLQGYIPSNYVA--EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKG 150

Query: 242 KYVLSGRTAENEHKHLILL--DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
           ++ LS        KH  +   D      TR R FS ++E + ++      +      +  
Sbjct: 151 EFSLSVLDGA-VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGL----CVKLG 205

Query: 300 SLNLIRPVPCP 310
              L   VP P
Sbjct: 206 KPCLKIQVPAP 216


>UniRef50_A1L2D2 Src homology 2 domain containing transforming protein D n=8
           Tax=Clupeocephala RepID=A1L2D2_DANRE
          Length = 391

 Score = 92.1 bits (227), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 35/151 (23%), Positives = 60/151 (39%), Gaps = 17/151 (11%)

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSRED 220
           T   + + +    G      P    S +  +   S          +  +VWYHG+LSR +
Sbjct: 249 TERLRCSRAPPTTGSMKLRKPSDPHSMIGERVDPSL--------PLEKQVWYHGSLSRSE 300

Query: 221 AQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--FSNI 276
           A++LL    E  +LVR S+ +   Y LS R+ +             R      +  F  I
Sbjct: 301 AESLLTLCKECSYLVRNSETSRLDYSLSLRSCQGFMHMKFSQCKDGRYILGQNSPPFETI 360

Query: 277 SELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
            E+I Y+  + + ++         L+L+ PV
Sbjct: 361 PEVIHYYTTHKLPIKGA-----EHLSLLFPV 386


>UniRef50_P42679 Megakaryocyte-associated tyrosine-protein kinase n=36
           Tax=Euteleostomi RepID=MATK_HUMAN
          Length = 507

 Score = 92.1 bits (227), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 15/140 (10%)

Query: 183 RHRSSLHRQSF----VSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQS 236
           +H +S          +    A +    +    W+HG +S ++A   L+   +G FLVR+S
Sbjct: 90  KHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRES 149

Query: 237 DHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRD 296
              PG YVL      +   + +L  + +        F N+ ++++++  +  A+      
Sbjct: 150 ARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAI------ 203

Query: 297 RETSLNLIRPVPCPGSDDIE 316
                 L+RP    G+   E
Sbjct: 204 ---CTKLVRPKRKHGTKSAE 220


>UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N5_TETNG
          Length = 966

 Score = 91.7 bits (226), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 14/104 (13%)

Query: 207 VGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
             K WYH NLSR  A+ +L     +G FLVR+    P  + +S R AE + KH  +    
Sbjct: 743 ESKEWYHANLSRSQAENMLMRVPRDGAFLVRK-RAEPNSFAISFR-AEGKIKHCRVQQEG 800

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             V      F ++ +LI Y+  + +  +         + L  P+
Sbjct: 801 QTVVLGTSEFDSLVDLISYYEKHPLYRK---------MKLRYPI 835



 Score = 89.8 bits (221), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 35/149 (23%), Positives = 54/149 (36%), Gaps = 31/149 (20%)

Query: 178 PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS-----REDAQALLKT----- 227
           P  P R          + N +A    +  V + W+HG L      R+ A+ LL       
Sbjct: 602 PTFPDRL------VLVLVNFQASNGMDQHVTEKWFHGKLGAGRDGRQIAERLLSEYCMET 655

Query: 228 ---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN-----RVRTRDRTFSNISEL 279
              +G FLVR+S+   G Y LS        +H  +             T +  F  +  L
Sbjct: 656 GAPDGSFLVRESETFVGDYTLSF-WRSGRVQHCRIHSRQEAGSPKFYLTDNLVFDTLFAL 714

Query: 280 IDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
           I+++    +      R  E  + L  PVP
Sbjct: 715 INHYQQVAL------RCNEFEMKLTEPVP 737


>UniRef50_Q9XXE5 Protein Y43C5B.2, partially confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q9XXE5_CAEEL
          Length = 245

 Score = 91.7 bits (226), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 29/126 (23%), Positives = 60/126 (47%), Gaps = 14/126 (11%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSD---HTPGKYVLSGRT-- 249
           ++  A      +  + +YHG L RED + +LK  GDF++R S+    +P   +LS     
Sbjct: 2   ASGTASMQRPSIEKEPYYHGFLPREDVKTVLKNNGDFVIRISEPQAGSPRSNILSVMHCV 61

Query: 250 --AENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
              E E KH ++    +++     +F +I E++++H+    +V+ +       + LI+ +
Sbjct: 62  PPMEEEIKHYVIKTKGDKIFIEKVSFLSIPEMVEWHLTKKESVQKD-------VFLIKAI 114

Query: 308 PCPGSD 313
                +
Sbjct: 115 SRQAWE 120


>UniRef50_C3Y8I0 Putative uncharacterized protein (Fragment) n=1 Tax=Branchiostoma
           floridae RepID=C3Y8I0_BRAFL
          Length = 101

 Score = 91.7 bits (226), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 24/94 (25%), Positives = 43/94 (45%), Gaps = 11/94 (11%)

Query: 208 GKVWYHGNL--SREDAQALLKT--------EGDFLVRQSDHTPGKYVLSGRTAENEHKHL 257
            + W++G +   R+ A  LL+         +G FLVR SD   G + L+   AE + KH 
Sbjct: 5   SEPWFYGKVAGGRKQADKLLREYVKTKSSPDGCFLVRDSDTFVGDFSLTF-WAEGKIKHC 63

Query: 258 ILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
            +  +          F ++ +L++Y+  N +  R
Sbjct: 64  RIKQDGRLFVIGTAQFESLIKLVNYYKENALYRR 97


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score = 91.7 bits (226), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 24/105 (22%), Positives = 50/105 (47%), Gaps = 12/105 (11%)

Query: 208 GKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
            + W+H  +SRE+ + LL+   +G FLVR+S + PG + L          + I   +  +
Sbjct: 145 NQPWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMAYHGKVEHYRIEQTSGGQ 204

Query: 266 V-RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           +   ++  FSN+++L+ ++  +   +            L+ P+ C
Sbjct: 205 LTCDKEEYFSNLTQLVSHYKRDADGLCH---------RLVTPIIC 240


>UniRef50_C3XYL7 Putative uncharacterized protein n=2 Tax=Branchiostoma floridae
           RepID=C3XYL7_BRAFL
          Length = 296

 Score = 91.3 bits (225), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 34/123 (27%), Positives = 54/123 (43%), Gaps = 4/123 (3%)

Query: 165 QANASTSNDGFTVPAPPMRHRSSL-HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQA 223
             N   +       APP+    ++   Q  + N       +D  G  WY GN+ RE A A
Sbjct: 151 PTNQGVAACQVMPSAPPVDACMNMATNQKAMMNTHGLMNNQDYRGAAWYKGNVPREMAMA 210

Query: 224 LLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR-VRTRDRTFSNISELI 280
            L+ +  G F+VR+S   PG Y LS RT      +LI   +    +    ++F ++  LI
Sbjct: 211 ELERQCAGAFMVRESGSNPGCYALSLRTMAGISNYLIGKTDKGYTIMGFGKSFPDLHTLI 270

Query: 281 DYH 283
            ++
Sbjct: 271 IHY 273


>UniRef50_B7Q2R0 Adaptor protein Crk, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7Q2R0_IXOSC
          Length = 310

 Score = 91.3 bits (225), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 32/106 (30%), Positives = 50/106 (47%), Gaps = 18/106 (16%)

Query: 211 WYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLSGRTAENEHKHLIL----LDNH 263
           W+ G +SR++A  +L  E   G FLVR S    G  VL  R  EN+  H I+     D  
Sbjct: 13  WFFGPMSRQEATDMLMAEHEAGIFLVRNSATISGDLVLCVR-EENKVSHYIINRVSQDEQ 71

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            R R  D+ F +I  L++++  + +           +  L++PVP 
Sbjct: 72  TRFRIGDQMFPDIPSLLNFYKLHYL----------DTTPLVKPVPS 107


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score = 90.9 bits (224), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 24/83 (28%), Positives = 39/83 (46%), Gaps = 5/83 (6%)

Query: 210 VWYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
            W+HG +SREDA+ +L+ EG    FLVR+S  + G YVLS         + I     +  
Sbjct: 8   CWFHGKISREDAEEILRREGSDGVFLVRESSSSEGDYVLSVLFKGEVVHYAIRRHGDDAF 67

Query: 267 RT--RDRTFSNISELIDYHVNNG 287
            +         +  LI+++  + 
Sbjct: 68  FSIHDHTPIHGLDSLIEHYQKDK 90



 Score = 59.7 bits (143), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 36/176 (20%), Positives = 52/176 (29%), Gaps = 58/176 (32%)

Query: 178 PAPPMRHRSSLHRQSFVSNCRA--PTVTEDVVGKVWYHGNLSREDAQALLK--------- 226
           P+   R R       F++      P    D+    WYHG L R  A   LK         
Sbjct: 253 PSDLARLRGHYQVVEFLNAYEPQRPLTHRDL----WYHGTLERTAAVDYLKDFAVKLLPN 308

Query: 227 ----------------------------TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
                                       T G +LVR S       VL+    +NE KH I
Sbjct: 309 LAHRQQQQQPDRDGNKENGECLDGLEQSTSGTYLVRYSAKQNVD-VLTMLY-DNEPKHFI 366

Query: 259 LLDNHN-RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV---PCP 310
           +    +          +++  LI+++                 +NL  PV   P P
Sbjct: 367 IQRQQDWLYIDEGPYMNSLEHLIEHYTR---------FSDGLPINLRFPVTPGPKP 413


>UniRef50_UPI00016E9A03 UPI00016E9A03 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9A03
          Length = 489

 Score = 90.9 bits (224), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 37/152 (24%), Positives = 63/152 (41%), Gaps = 17/152 (11%)

Query: 155 TAINVNTFDAQANA-STSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYH 213
             +NV+       + S   D   +P+PP     S  R S   + +A           W+H
Sbjct: 333 QTLNVDELGLLLRSRSGGADLEPLPSPPDVSAPSSQRGSTELSSQA---------YPWFH 383

Query: 214 GNLSREDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHNRVR 267
           G +SR  A  L+++      G FLVRQS+   G YVL+    + + KHL L L    + R
Sbjct: 384 GPISRVKAAYLVQSSGPEGHGVFLVRQSETRRGDYVLTF-NYQGKAKHLRLSLTEWGQCR 442

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
            +   F ++ +++ +     + +        T
Sbjct: 443 VQHLRFPSVMDMLSHFRLFPIPLECGAAGAVT 474


>UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3B48
          Length = 325

 Score = 90.9 bits (224), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 20/96 (20%), Positives = 49/96 (51%), Gaps = 2/96 (2%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEG--DFLVRQSDHTPGKYVLSGRTAENEHKHL 257
           P    ++    W+  N SR  A+ LL+ +G  +F++R    +PG++ +S R   +     
Sbjct: 47  PQNYIEIQTPRWFQENASRSAAEELLRHKGVGEFVIRGCQSSPGEFSISVRHESDVQHFK 106

Query: 258 ILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           ++ D+  +       F+++++L+D++  + ++   E
Sbjct: 107 VMRDSRGQYFLWSEKFTSLNKLVDFYRTSSISKTRE 142


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score = 90.9 bits (224), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 37/126 (29%), Positives = 57/126 (45%), Gaps = 12/126 (9%)

Query: 191 QSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSG 247
               SN   P     +    WY G++SR+ A++LLK    EG F+VR+S  T G Y LS 
Sbjct: 390 GYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSL 448

Query: 248 --RTAENEHKHLILLDN--HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNL 303
             +  ++  KH  +  N       +       I +LI+YH +N   +    R + +  + 
Sbjct: 449 HTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGL--ACRLKSSPCD- 505

Query: 304 IRPVPC 309
            RPVP 
Sbjct: 506 -RPVPP 510


>UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax=Euteleostomi
           RepID=SHE_HUMAN
          Length = 495

 Score = 90.9 bits (224), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 24/106 (22%), Positives = 51/106 (48%), Gaps = 9/106 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +  + WYHG +SR +A++ L+   E  +LVR S+    +Y ++ +T++     ++     
Sbjct: 390 LEKQPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKD 449

Query: 264 NRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           N+      +  F +I E++ Y+ N  +  +         + L+ PV
Sbjct: 450 NKYTLNQTSAVFDSIPEVVHYYSNEKLPFKGA-----EHMTLLYPV 490


>UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME
          Length = 506

 Score = 90.9 bits (224), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 9/130 (6%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDH 238
           P     S  R     +   P   +++    WY G +SRE+A+++L  K +G FLVR +  
Sbjct: 3   PSPLHYSTMRPQAPGSLVDP-NEDELRMAPWYWGRISREEAKSILHGKPDGSFLVRDALS 61

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRV-RTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
             G+Y L+    +   K + +     +        F+++ E+I+Y+  N +++ +    +
Sbjct: 62  MKGEYTLTLM-KDGCEKLIKICHMDRKYGFIETDLFNSVVEMINYYKENSLSMYN----K 116

Query: 298 ETSLNLIRPV 307
              + L  P+
Sbjct: 117 TLDITLSNPI 126



 Score = 55.1 bits (131), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 22/94 (23%), Positives = 41/94 (43%), Gaps = 11/94 (11%)

Query: 218 REDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--F 273
           R +A+ +LK    G FL+R  D   G Y LS    +N  +H ++ +             +
Sbjct: 344 RRNAEEMLKGAPSGTFLIRARDA--GHYALSIAC-KNIVQHCLIYETSTGFGFAAPYNIY 400

Query: 274 SNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           + +  L++++ NN +    E  +   +  L  PV
Sbjct: 401 ATLKSLVEHYANNSL----EEHNDTLTTTLRWPV 430


>UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SAX0_TETNG
          Length = 283

 Score = 90.5 bits (223), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 20/96 (20%), Positives = 49/96 (51%), Gaps = 2/96 (2%)

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEG--DFLVRQSDHTPGKYVLSGRTAENEHKHL 257
           P    ++    W+  N SR  A+ LL+ +G  +F++R    +PG++ +S R   +     
Sbjct: 47  PQNYIEIQTPRWFQENASRSAAEELLRHKGVGEFVIRGCQSSPGEFSISVRHESDVQHFK 106

Query: 258 ILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           ++ D+  +       F+++++L+D++  + ++   E
Sbjct: 107 VMRDSRGQYFLWSEKFTSLNKLVDFYRTSSISKTRE 142


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score = 90.5 bits (223), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 32/182 (17%), Positives = 67/182 (36%), Gaps = 10/182 (5%)

Query: 142 FIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPT 201
            +E+  K++  L     ++  D                   + RS   R+          
Sbjct: 58  KMEEKEKIVVALYPYEAIHADDLGFKKGEKLKIIEEHGEWWKARSLTTRKEGFIPSNYVA 117

Query: 202 VTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGR----TAENE 253
             + +  + W++ +++R+DA+  L       G +L+R+S+ + G Y LS R      ++ 
Sbjct: 118 EADTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDV 177

Query: 254 HKHLILL--DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
            KH  +   DN     +   TFS+IS +I ++      +  +           +P     
Sbjct: 178 VKHYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKAQKPWDKDA 237

Query: 312 SD 313
            +
Sbjct: 238 WE 239


>UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo salar
           RepID=B5X487_SALSA
          Length = 289

 Score = 90.5 bits (223), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 26/119 (21%), Positives = 53/119 (44%), Gaps = 3/119 (2%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAEN 252
                P    +     W+    SR  A+ LL  +  G FL+R S  +PG++ +S R   +
Sbjct: 42  QEGFVPQNYIERQTPSWFKETASRSSAEELLMSREVGGFLIRGSQSSPGEFSISVRHEFD 101

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP-VPCP 310
                ++ D+          F+++++L+D++ N  ++ + +   R+ S +   P  P P
Sbjct: 102 VQHFKVMKDSKGHYFLWSEKFTSLNKLVDFYKNTSISKQRDIYLRDGSRDDQSPSTPQP 160


>UniRef50_C4Q974 Growth factor receptor-bound protein, putative n=2 Tax=Schistosoma
           RepID=C4Q974_SCHMA
          Length = 317

 Score = 90.1 bits (222), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 25/106 (23%), Positives = 44/106 (41%), Gaps = 11/106 (10%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALL-----------KTEGDFLVRQSDHTPGKY 243
                P     +    WY    SR +A+A L           + +G F++RQS++ PG++
Sbjct: 44  QEGMVPANYISLYPHPWYIPRCSRREAEARLLETDPDTNRDVQPDGAFILRQSENDPGQF 103

Query: 244 VLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
            +S +   +     I  D   +       F +I+ LIDYH +  + 
Sbjct: 104 SISVKEGSSVLHFRIFFDPKGKYYIWTNKFDSINALIDYHRHQTIY 149


>UniRef50_A9V5M9 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V5M9_MONBE
          Length = 392

 Score = 90.1 bits (222), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 6/81 (7%)

Query: 210 VWYHGNLSREDAQALLKT----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
            + HG +SRE+  AL+++    EG FLVR+S  TPG Y LS   A+ + +H  +      
Sbjct: 29  PYMHGKISREEVDALVRSNGFSEGLFLVRESARTPGDYALSV-VAQGKLQHFKISRKTGL 87

Query: 266 VRTRD-RTFSNISELIDYHVN 285
            R  D   F ++ EL+ ++ N
Sbjct: 88  YRIDDGPGFGSLDELVQFYRN 108


>UniRef50_UPI0000E460CB PREDICTED: similar to V-crk sarcoma virus CT10 oncogene homolog
           (avian)-like n=1 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E460CB
          Length = 305

 Score = 90.1 bits (222), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 27/117 (23%), Positives = 53/117 (45%), Gaps = 15/117 (12%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAEN 252
            + +AP   +D    +W+ G ++R +   LL  K  G FLVR S   PG  VL   +  +
Sbjct: 4   QDDKAPF--DDSNKHLWHFGGITRSETDNLLIQKRPGTFLVRDSRTCPGDSVLCV-SENS 60

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           +  H I+    ++    D+ FS + ++++++  + +           +  L+ P P 
Sbjct: 61  KVSHYIITRKADQFVIGDQIFSTLPDILNFYRGHYL----------DTTVLVEPCPK 107


>UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tetraodon nigroviridis
           RepID=UPI00017B55E8
          Length = 497

 Score = 90.1 bits (222), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 29/127 (22%), Positives = 53/127 (41%), Gaps = 22/127 (17%)

Query: 171 SNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--- 227
             D  ++P P    + + H                +    W+HG +SR  A  L+++   
Sbjct: 385 PADPASLPPPEPAVQKTDHF---------------LFSYPWFHGPISRVKAAHLVQSSGP 429

Query: 228 --EGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHNRVRTRDRTFSNISELIDYHV 284
              G FLVRQS+   G YVL+    + + KHL L L    + R +   F ++ +++ +  
Sbjct: 430 EGHGVFLVRQSETRRGDYVLTF-NYQGKAKHLRLSLTEWGQCRVQHLRFPSVMDMLSHFR 488

Query: 285 NNGMAVR 291
              + + 
Sbjct: 489 LYPIPLE 495


>UniRef50_Q9Y1Y2 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y2_9METZ
          Length = 743

 Score = 90.1 bits (222), Expect = 9e-17,   Method: Composition-based stats.
 Identities = 32/111 (28%), Positives = 47/111 (42%), Gaps = 12/111 (10%)

Query: 208 GKVWYHGNLSREDAQALL------KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
            + WYHG ++RE+A  L+      + EG FLVR+S  TPG YVL+     N  +  I+  
Sbjct: 7   AERWYHGKITRENAAHLVSQGPITRREGLFLVRESTRTPGSYVLTLWAKGNVQQFQIMGH 66

Query: 262 NHNRVRTR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
                       F  + ELI ++      +  +  D         P P PG
Sbjct: 67  GEGWFSVDNGPLFQGLDELIHHYQLKPDGLPVQLNDYVIG----NP-PPPG 112



 Score = 70.9 bits (172), Expect = 5e-11,   Method: Composition-based stats.
 Identities = 20/108 (18%), Positives = 41/108 (37%), Gaps = 14/108 (12%)

Query: 213 HGNLSREDAQALLKT----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD-NHNRVR 267
           H  + R +A   LK     +G FL+R +   PG Y L+    +  + + ++ + +     
Sbjct: 294 HKAIDRNNAVETLKQKGLSDGSFLIRPNSRKPGSYALTLVYKQTPYHYEVVCESDCWYFI 353

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDDI 315
                F  +  ++D++                   L+ PVP  G  ++
Sbjct: 354 DDGPLFDTLPAVVDHYT---------IFADGLPTTLLYPVPPSGRKNV 392


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score = 89.8 bits (221), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 28/126 (22%), Positives = 52/126 (41%), Gaps = 16/126 (12%)

Query: 186 SSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE----GDFLVRQSDHTPG 241
           ++       SN  A   + D   + W+ G + R +A+ +L       G FL+R S+ TPG
Sbjct: 99  TAGKEGYIPSNYVAEYKSLD--AEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPG 156

Query: 242 KYVLSGRTAENEHKHLILL-DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
            + LS +  +    + +   ++ +   TR  TF  + EL+D++                 
Sbjct: 157 DFSLSVKDQDRVRHYRVRRLEDGSLFVTRRSTFQILHELVDHYK---------IETDGLC 207

Query: 301 LNLIRP 306
             L+ P
Sbjct: 208 CKLLYP 213


>UniRef50_B0R097 Src homology 2 domain containing F (Fragment) n=5 Tax=Eutheria
           RepID=B0R097_MOUSE
          Length = 161

 Score = 89.8 bits (221), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 20/87 (22%), Positives = 45/87 (51%), Gaps = 4/87 (4%)

Query: 211 WYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WYHG +SR DA+ LL+   E  +LVR S+ +   + LS ++++      +     ++   
Sbjct: 72  WYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVL 131

Query: 269 RDRT--FSNISELIDYHVNNGMAVRSE 293
              +  FS++ E++ ++ +  + ++  
Sbjct: 132 GQNSPPFSSVPEIVHHYASRKLPIKGA 158


>UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7T185_NEMVE
          Length = 983

 Score = 89.8 bits (221), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 28/95 (29%), Positives = 47/95 (49%), Gaps = 4/95 (4%)

Query: 212 YHGNLSREDAQA--LLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR-T 268
           + G + R +A+   + +++G FLVR+S +  G+Y LS R   N  KH+ +         T
Sbjct: 661 FAGKMDRTEAEQETMGRSDGTFLVRESANRAGEYALSVRF-RNATKHIKIPYEDGTFCLT 719

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNL 303
           + + F +I EL+ Y+  N + V   G D      L
Sbjct: 720 QSKVFDSIPELVAYYRENTLGVSFTGLDTTLRCGL 754


>UniRef50_UPI0000D57699 PREDICTED: similar to protein-tyrosine kinase n=2 Tax=Endopterygota
           RepID=UPI0000D57699
          Length = 725

 Score = 89.8 bits (221), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 13/103 (12%)

Query: 211 WYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           WYHG LSRE  + LL    + +G FLVR+S+ + G +VLS           I   + +  
Sbjct: 9   WYHGKLSREATENLLKEEGRPDGSFLVRESNSSTGDFVLSVLHNNEVSHFQIRRHSEDAF 68

Query: 267 RTRDR--TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
            + D       +  LI+++V N   + SEG      L+L  PV
Sbjct: 69  FSIDENTKIHGLESLIEHYV-NTKGILSEG------LSLTVPV 104



 Score = 70.5 bits (171), Expect = 8e-11,   Method: Composition-based stats.
 Identities = 27/138 (19%), Positives = 53/138 (38%), Gaps = 12/138 (8%)

Query: 150 IDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGK 209
            DV+   +++N        +  +    +P+   R    +     + N + P         
Sbjct: 232 KDVVKALLSLNAP-----VNPRDKDNQLPSHLARKNGFIECAEILENYQCPA--PKTHRS 284

Query: 210 VWYHGNLSREDAQALLK----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
            WYHG L R +A+  +K     +G FLVR SD    + VL+       + ++I   +   
Sbjct: 285 YWYHGTLDRHEAETTIKQFSTKDGTFLVRWSDRNK-ERVLTLINESLFYNYIIRKQDDYL 343

Query: 266 VRTRDRTFSNISELIDYH 283
                    ++  +I+Y+
Sbjct: 344 FIDNGPYLESLEHIIEYY 361


>UniRef50_A8WMP8 Putative uncharacterized protein n=1 Tax=Caenorhabditis briggsae
           RepID=A8WMP8_CAEBR
          Length = 284

 Score = 89.8 bits (221), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 31/120 (25%), Positives = 54/120 (45%), Gaps = 22/120 (18%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAE---------NE 253
           ++ + +YHG L REDA ALL   GDFL+R S+ T G    ++LS  T +           
Sbjct: 11  IIREGYYHGLLPREDAAALLTQNGDFLIRISEPTDGAEQNFILSCMTDDKSKSNDENPGM 70

Query: 254 HKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
              ++   N   +   + +F  I +L+++H  N +           ++ L RP+     +
Sbjct: 71  QNFVVGFQNGRYLVAENHSFPTIEKLVEFHKKNRI----------QNIFLNRPIMRQSWE 120


>UniRef50_Q4SVT4 Chromosome undetermined SCAF13726, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SVT4_TETNG
          Length = 1377

 Score = 89.4 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 32/144 (22%), Positives = 52/144 (36%), Gaps = 24/144 (16%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS-----REDAQALLK-------TEGDF 231
           H  +   +            E    + W+HG L      R+ A+ LL+        +G F
Sbjct: 543 HYQTADEEEDDEVKEECNNNEQHCAERWFHGKLGGGRDGRQVAEKLLQEYCEGGAKDGTF 602

Query: 232 LVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN-----RVRTRDRTFSNISELIDYHVNN 286
           LVR+S+   G Y LS        +H  +             T +  F ++  LI ++ + 
Sbjct: 603 LVRESETFVGDYTLSF-WRSGRVQHCRIHSRQESGSTRFYLTDNLVFDSLYRLICHYRDT 661

Query: 287 GMAVRSEGRDRETSLNLIRPVPCP 310
            +      R  E  + L  PVP P
Sbjct: 662 PL------RCNEFEMRLGNPVPQP 679



 Score = 82.8 bits (203), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 26/106 (24%), Positives = 47/106 (44%), Gaps = 17/106 (16%)

Query: 207 VGKVWYHGNLSREDAQALLKT---EGDFLVRQ-SDHTPGKYVLSGRTAENEHKHLILLDN 262
             + WYH +L+R  A+ +L     +G FLVR+ S+H    Y +S R AE + KH  +   
Sbjct: 683 ESREWYHSSLTRVQAEHMLMRVPRDGAFLVRKRSEHN--SYAISFR-AEGKIKHCRIQQE 739

Query: 263 HNRVRTRD-RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                      F ++ +L+ Y+  + +  +         + L  P+
Sbjct: 740 GRLFMLGSSAEFESLMDLVSYYEKHPLYRK---------MKLRYPI 776


>UniRef50_P50745 SH2B adapter protein 3 n=2 Tax=Rattus norvegicus RepID=SH2B3_RAT
          Length = 368

 Score = 89.4 bits (220), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 24/92 (26%), Positives = 45/92 (48%), Gaps = 7/92 (7%)

Query: 206 VVGKVWYHGNLSREDAQALLK-----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
           +    W+HG +SR  A  L++       G FLVRQS+   G+YVL+    +   KHL L+
Sbjct: 114 LSCYPWFHGPISRVRAAQLVQLQGPDAHGVFLVRQSESRRGEYVLTF-NLQGRAKHLRLV 172

Query: 261 -DNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
                + R +   F ++ +++ +   + + + 
Sbjct: 173 LTERGQCRVQHLHFPSVVDMLRHFQRSPIPLE 204


>UniRef50_UPI0001924162 PREDICTED: similar to SH2-B PH domain containing signaling mediator
           1 n=1 Tax=Hydra magnipapillata RepID=UPI0001924162
          Length = 984

 Score = 89.4 bits (220), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 28/154 (18%), Positives = 58/154 (37%), Gaps = 15/154 (9%)

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
             N   +Q + +       V +P    +                    +    W+HG ++
Sbjct: 777 GYNITSSQDSQAAPITTPEVLSPIPETQCDWTNPFGE--------NHPLAVYPWFHGTIT 828

Query: 218 REDAQALLKTEGD-----FLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHNRVRTRDR 271
           R  +   +  +G      FLVRQS+   G+YVL+    +   KHL + L++    R +  
Sbjct: 829 RVQSSMHVLQQGSSWHGVFLVRQSETRRGEYVLTF-NLQGRSKHLRMSLNSEGNCRVQHL 887

Query: 272 TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
            F  I +++++   + + + + G D       + 
Sbjct: 888 RFETIFDMLEHFRLHPIPLENNGSDDVRLTGYVY 921


>UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi RepID=SH2B3_HUMAN
          Length = 575

 Score = 89.0 bits (219), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 29/126 (23%), Positives = 55/126 (43%), Gaps = 10/126 (7%)

Query: 175 FTVPAPPMRHRSSLHRQSFVSNCRAPTVTED---VVGKVWYHGNLSREDAQALLK----- 226
            +  + P     SL++ +       P   +    +    W+HG +SR  A  L++     
Sbjct: 325 PSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQLVQLQGPD 384

Query: 227 TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL-LDNHNRVRTRDRTFSNISELIDYHVN 285
             G FLVRQS+   G+YVL+    +   KHL L L    + R +   F ++ +++ +   
Sbjct: 385 AHGVFLVRQSETRRGEYVLTF-NFQGIAKHLRLSLTERGQCRVQHLHFPSVVDMLHHFQR 443

Query: 286 NGMAVR 291
           + + + 
Sbjct: 444 SPIPLE 449


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q9TYT3 Putative uncharacterized protein n=4 Tax=Caenorh...   325   1e-87
UniRef50_A8WZ72 C. briggsae CBR-SHC-1 protein n=2 Tax=Caenorhabd...   278   2e-73
UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming pr...   262   1e-68
UniRef50_Q6NPB1 RH57813p n=16 Tax=Neoptera RepID=Q6NPB1_DROME         177   5e-43
UniRef50_Q3ZAX3 Shc3 protein n=9 Tax=Euteleostomi RepID=Q3ZAX3_M...   156   8e-37
UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain pr...   156   1e-36
UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi...   154   3e-36
UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda Rep...   152   2e-35
UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi...   151   2e-35
UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi...   150   7e-35
UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=...   150   8e-35
UniRef50_B4IYA5 GH15138 n=5 Tax=Drosophila RepID=B4IYA5_DROGR         150   8e-35
UniRef50_O14492 SH2B adapter protein 2 n=4 Tax=Catarrhini RepID=...   145   2e-33
UniRef50_A7RR81 Predicted protein n=1 Tax=Nematostella vectensis...   145   2e-33
UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2...   144   3e-33
UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=...   141   3e-32
UniRef50_Q9JID9 SH2B adapter protein 2 n=13 Tax=Euteleostomi Rep...   139   1e-31
UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=...   137   7e-31
UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein...   135   2e-30
UniRef50_A9V8S2 Predicted protein n=1 Tax=Monosiga brevicollis R...   134   3e-30
UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Ta...   134   4e-30
UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1...   131   2e-29
UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9...   129   2e-28
UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleosto...   127   6e-28
UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n...   127   7e-28
UniRef50_A9V4N6 Predicted protein n=1 Tax=Monosiga brevicollis R...   125   2e-27
UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Siluran...   125   2e-27
UniRef50_UPI0001A5EB2D PREDICTED: hypothetical protein XP_002347...   125   3e-27
UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 ...   124   3e-27
UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata Re...   124   5e-27
UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO          123   7e-27
UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 T...   123   8e-27
UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepI...   123   9e-27
UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS          122   1e-26
UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MX...   122   1e-26
UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=S...   122   1e-26
UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Ta...   121   4e-26
UniRef50_C1LZD5 Signal transduction protein lnk-related n=1 Tax=...   120   5e-26
UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=...   120   5e-26
UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyro...   120   7e-26
UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=...   119   9e-26
UniRef50_Q21429 Protein K11E4.2, confirmed by transcript evidenc...   119   1e-25
UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=...   119   1e-25
UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=A...   119   2e-25
UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine ki...   118   2e-25
UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi R...   118   2e-25
UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata ...   118   2e-25
UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   118   3e-25
UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=...   117   5e-25
UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activati...   117   6e-25
UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata ...   117   6e-25
UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis R...   117   7e-25
UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS         116   8e-25
UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein...   116   1e-24
UniRef50_UPI000179134F PREDICTED: similar to signal transduction...   116   1e-24
UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun se...   116   1e-24
UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group Rep...   116   1e-24
UniRef50_UPI0000612FE6 UPI0000612FE6 related cluster n=1 Tax=Bos...   116   1e-24
UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun seq...   116   2e-24
UniRef50_UPI0001757DDC PREDICTED: similar to MGC80357 protein n=...   115   2e-24
UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76...   115   2e-24
UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax...   115   2e-24
UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=...   114   3e-24
UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumeta...   114   3e-24
UniRef50_B7PEL7 Signal transduction protein lnk-realted, putativ...   114   4e-24
UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine ki...   114   4e-24
UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homo...   114   4e-24
UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambi...   114   5e-24
UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor pro...   114   6e-24
UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID...   114   6e-24
UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata R...   114   6e-24
UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigida...   114   6e-24
UniRef50_A2RUZ0 Zgc:158474 protein n=2 Tax=Euteleostomi RepID=A2...   113   7e-24
UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis R...   113   7e-24
UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specif...   113   7e-24
UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein...   113   1e-23
UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 1...   112   1e-23
UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pe...   112   1e-23
UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleo...   112   1e-23
UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes relate...   112   1e-23
UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, part...   112   2e-23
UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadore...   112   2e-23
UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax...   112   2e-23
UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Ta...   112   2e-23
UniRef50_UPI000186F2CC Phosphatidylinositol 3-kinase regulatory ...   112   2e-23
UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes sca...   111   3e-23
UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=S...   111   3e-23
UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl...   111   3e-23
UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome ...   111   3e-23
UniRef50_UPI00016E9884 UPI00016E9884 related cluster n=7 Tax=Tak...   111   4e-23
UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D...   111   5e-23
UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes relate...   111   5e-23
UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor ...   110   6e-23
UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297...   110   6e-23
UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate p...   110   6e-23
UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome s...   110   6e-23
UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE     110   6e-23
UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4...   110   7e-23
UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=...   110   7e-23
UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tet...   110   8e-23
UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase ...   110   8e-23
UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax...   110   8e-23
UniRef50_UPI00017B392D UPI00017B392D related cluster n=2 Tax=Tet...   110   8e-23
UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activati...   109   9e-23
UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria...   109   1e-22
UniRef50_A1L2D2 Src homology 2 domain containing transforming pr...   109   1e-22
UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Me...   109   1e-22
UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata...   109   1e-22
UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q...   109   1e-22
UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID...   109   1e-22
UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga g...   109   2e-22
UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 ...   109   2e-22
UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pe...   109   2e-22
UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=...   109   2e-22
UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Tak...   109   2e-22
UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=...   109   2e-22
UniRef50_UPI00017B2C65 UPI00017B2C65 related cluster n=1 Tax=Tet...   109   2e-22
UniRef50_B0WI58 Putative uncharacterized protein n=2 Tax=Culicin...   108   2e-22
UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis R...   108   2e-22
UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=...   108   2e-22
UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, part...   108   2e-22
UniRef50_UPI00015B58E2 PREDICTED: similar to signal transduction...   108   2e-22
UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Stron...   108   3e-22
UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun se...   108   3e-22
UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup...   108   3e-22
UniRef50_A9UWT7 Predicted protein n=1 Tax=Monosiga brevicollis R...   108   3e-22
UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax...   108   3e-22
UniRef50_UPI00004D6B5A SH2B adapter protein 3 (Lymphocyte-specif...   108   3e-22
UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia mal...   107   4e-22
UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus...   107   4e-22
UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor recep...   107   5e-22
UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eu...   107   5e-22
UniRef50_A8WHN9 Novel protein similar to vertebrate breast cance...   107   5e-22
UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ova...   107   5e-22
UniRef50_Q7K137 Lnk, isoform A n=13 Tax=Drosophila RepID=Q7K137_...   107   6e-22
UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein ki...   107   6e-22
UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis R...   107   7e-22
UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepI...   107   7e-22
UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D...   107   7e-22
UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi R...   107   7e-22
UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicin...   107   7e-22
UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n...   106   8e-22
UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis R...   106   9e-22
UniRef50_A8P596 SH2 domain containing protein n=1 Tax=Brugia mal...   106   9e-22
UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=...   106   1e-21
UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio Rep...   106   1e-21
UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus...   106   1e-21
UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax...   106   1e-21
UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona ...   106   1e-21
UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA    106   1e-21
UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clu...   106   1e-21
UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6N...   106   2e-21
UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU...   106   2e-21
UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb...   106   2e-21
UniRef50_UPI0000D9EE2E PREDICTED: similar to src homology 2 doma...   105   2e-21
UniRef50_UPI000192756A PREDICTED: similar to predicted protein n...   105   2e-21
UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9...   105   2e-21
UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3...   105   2e-21
UniRef50_Q9BRG2 SH2 domain-containing protein 3A n=12 Tax=Euther...   105   2e-21
UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pa...   105   2e-21
UniRef50_C4Q974 Growth factor receptor-bound protein, putative n...   105   2e-21
UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID...   105   3e-21
UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putativ...   105   3e-21
UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS         105   3e-21
UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi Rep...   105   3e-21
UniRef50_UPI0000E45D4F PREDICTED: similar to SH2 domain containi...   105   3e-21
UniRef50_B7QIL2 Dreadlocks/dock, putative (Fragment) n=1 Tax=Ixo...   105   3e-21
UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Met...   104   3e-21
UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 ...   104   3e-21
UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID...   104   3e-21
UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic regio...   104   4e-21
UniRef50_Q5T4P3 Phosphoinositide-3-kinase, regulatory subunit 3 ...   104   4e-21
UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax...   104   4e-21
UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q...   104   4e-21
UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 ...   104   4e-21
UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicu...   104   4e-21
UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coeloma...   104   4e-21
UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE        104   4e-21
UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine ki...   104   5e-21
UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluvia...   104   5e-21
UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1...   104   5e-21
UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga g...   104   5e-21
UniRef50_UPI000186DA97 tyrosine-protein kinase transforming prot...   104   6e-21
UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related ad...   104   6e-21
UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazo...   104   6e-21
UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME        104   6e-21
UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metaz...   104   6e-21
UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isofo...   104   7e-21
UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostom...   103   7e-21
UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS         103   7e-21
UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform ...   103   7e-21
UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateri...   103   7e-21
UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_D...   103   7e-21
UniRef50_A9UPM2 Predicted protein n=1 Tax=Monosiga brevicollis R...   103   8e-21
UniRef50_Q8AVM4 Sh2d3c-prov protein n=7 Tax=Euteleostomi RepID=Q...   103   8e-21
UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tet...   103   8e-21
UniRef50_UPI00015B5D64 PREDICTED: similar to LD41184p n=1 Tax=Na...   103   9e-21
UniRef50_Q4SMI9 Chromosome 18 SCAF14547, whole genome shotgun se...   103   1e-20
UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA ...   102   1e-20
UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gam...   102   1e-20
UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subuni...   102   1e-20
UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2...   102   1e-20
UniRef50_Q05DQ0 PIK3R3 protein (Fragment) n=19 Tax=Chordata RepI...   102   1e-20
UniRef50_UPI00015B496D PREDICTED: similar to conserved hypotheti...   102   2e-20
UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun seq...   102   2e-20
UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptat...   102   2e-20
UniRef50_UPI0000F2151D PREDICTED: similar to SH2B adapter protei...   102   2e-20
UniRef50_UPI00016E9A01 UPI00016E9A01 related cluster n=3 Tax=Tet...   102   2e-20
UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeni...   101   3e-20
UniRef50_UPI00017B1E0A UPI00017B1E0A related cluster n=1 Tax=Tet...   101   3e-20
UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequ...   101   3e-20
UniRef50_UPI00019266B8 PREDICTED: similar to Bam32 n=1 Tax=Hydra...   101   3e-20
UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax...   101   3e-20
UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostoma...   101   3e-20
UniRef50_Q4S6Q5 Chromosome undetermined SCAF14724, whole genome ...   101   3e-20
UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogast...   101   3e-20
UniRef50_UPI0000DB7594 PREDICTED: similar to CG9098-PA, isoform ...   101   4e-20
UniRef50_B4DVK9 cDNA FLJ53479, highly similar to Proto-oncogene ...   101   4e-20
UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2...   101   4e-20
UniRef50_UPI00006A1A97 SH2B adapter protein 2 (SH2 and PH domain...   101   4e-20
UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA   100   4e-20
UniRef50_UPI000179EA7A UPI000179EA7A related cluster n=1 Tax=Bos...   100   5e-20
UniRef50_A9V510 Predicted protein n=1 Tax=Monosiga brevicollis R...   100   5e-20
UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera...   100   5e-20
UniRef50_UPI0001924162 PREDICTED: similar to SH2-B PH domain con...   100   5e-20
UniRef50_UPI00006A5E95 PREDICTED: similar to HrSH2 n=1 Tax=Ciona...   100   6e-20
UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun se...   100   6e-20
UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistoso...   100   7e-20
UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 T...   100   7e-20
UniRef50_UPI00019269FE PREDICTED: similar to protein tyrosine ph...   100   8e-20
UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis...   100   8e-20
UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6...   100   9e-20
UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo sal...   100   1e-19
UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepI...   100   1e-19
UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephyd...   100   1e-19
UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O...   100   1e-19
UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protei...   100   1e-19
UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabd...   100   1e-19
UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME       100   1e-19
UniRef50_Q4SW52 Chromosome undetermined SCAF13690, whole genome ...   100   1e-19
UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit...   100   1e-19
UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine ph...    99   1e-19
UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphoty...    99   1e-19
UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphod...    99   1e-19
UniRef50_UPI00016E9A03 UPI00016E9A03 related cluster n=1 Tax=Tak...    99   1e-19
UniRef50_UPI000180BDCA PREDICTED: similar to Src homology 2 doma...    99   2e-19
UniRef50_UPI00006A1C30 UPI00006A1C30 related cluster n=1 Tax=Xen...    99   2e-19
UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus pur...    99   2e-19
UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorh...    99   2e-19
UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidenc...    99   2e-19

Sequences not found previously or not previously below threshold:

>UniRef50_Q9TYT3 Putative uncharacterized protein n=4 Tax=Caenorhabditis elegans
           RepID=Q9TYT3_CAEEL
          Length = 316

 Score =  325 bits (833), Expect = 1e-87,   Method: Composition-based stats.
 Identities = 316/316 (100%), Positives = 316/316 (100%)

Query: 1   MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA 60
           MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA
Sbjct: 1   MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA 60

Query: 61  AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT 120
           AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT
Sbjct: 61  AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT 120

Query: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP 180
           ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP
Sbjct: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP 180

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP 240
           PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP
Sbjct: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP 240

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
           GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS
Sbjct: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300

Query: 301 LNLIRPVPCPGSDDIE 316
           LNLIRPVPCPGSDDIE
Sbjct: 301 LNLIRPVPCPGSDDIE 316


>UniRef50_A8WZ72 C. briggsae CBR-SHC-1 protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8WZ72_CAEBR
          Length = 317

 Score =  278 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 176/320 (55%), Positives = 228/320 (71%), Gaps = 15/320 (4%)

Query: 1   MLNVEPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA 60
           M+ ++P +A+ELRSSGV+L+A YLGS+PV ES++VMVSEMR QVV ECIQ VAA VG+T 
Sbjct: 1   MVKIDPIYAQELRSSGVTLAAVYLGSIPVQESMSVMVSEMRSQVVGECIQIVAAKVGLTP 60

Query: 61  AREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT 120
            R++NP+V+R+IGEVK+ENF VD+NISSKM+K+I+ SRLIQRHP SFFSFG+QGQ+GTDT
Sbjct: 61  ERDVNPIVARIIGEVKQENFNVDLNISSKMVKVIRSSRLIQRHPLSFFSFGSQGQRGTDT 120

Query: 121 ELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTV--- 177
           E MFGYIAKNK+G DRRCHV+  + V KL+D L  AI VNT DA+A     N        
Sbjct: 121 ENMFGYIAKNKNGEDRRCHVMSSKAVQKLLDTLVAAIQVNTEDAKAKEMAENPQAASTSG 180

Query: 178 --------PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG 229
                   P  P +   +     +V+  R   V E+V  + WYHG++SR+ AQ+L++  G
Sbjct: 181 TSGPSSTDPLRPPKFTCTE----YVALGRITLVYENVKNQPWYHGHISRDIAQSLIRQPG 236

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
           DFLVR SDHT GK+VLSG T   +HKHLILLD  N+VRT ++TF  I+EL+  H+ NG  
Sbjct: 237 DFLVRCSDHTTGKFVLSGMTEHGDHKHLILLDEKNQVRTPEKTFPTITELVRSHMENGQP 296

Query: 290 VRSEGRDRETSLNLIRPVPC 309
           VRS+G   +T+L L   +P 
Sbjct: 297 VRSDGPQNQTALMLENAIPR 316


>UniRef50_UPI00005A1414 PREDICTED: similar to SHC transforming protein 1 (SH2 domain
           protein C1) (Src homology 2 domain containing
           transforming protein C1) isoform 4 n=1 Tax=Canis lupus
           familiaris RepID=UPI00005A1414
          Length = 442

 Score =  262 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 96/312 (30%), Positives = 148/312 (47%), Gaps = 23/312 (7%)

Query: 7   SFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV--GVTAAREI 64
              +++   GVS    Y+G V V++S+  +    R QV  E I  V   V     A R  
Sbjct: 143 HPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRR 202

Query: 65  NPV---VSRVIGE--VKKENFPVDINISSKMIKII--KQSRLIQRHPFSFFSFGAQGQKG 117
            P    +S ++G   +K    P+ + +S+  + ++     ++I  H     SF + G   
Sbjct: 203 KPCSRPLSAILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDP- 261

Query: 118 TDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTV 177
            DT     Y+AK+     R CH++  E    L   + + I    F+ +      N    V
Sbjct: 262 -DTAEYVAYVAKDP-VNQRACHIL--ECPEGLAQDVISTIG-QAFELRFKQYLRNPPKLV 316

Query: 178 PAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSD 237
                  RS L  Q+  S+C        + G+ W+HG LSR +A+ALL+  GDFLVR+S 
Sbjct: 317 TPHDSLARSCLLLQARSSSC---MPGHRLRGEPWFHGKLSRREAEALLQLNGDFLVREST 373

Query: 238 HTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
            TPG+YVL+G  +    KHL+L+D    VRT+D  F ++S LI YHV+N + + S G   
Sbjct: 374 TTPGQYVLTGLQSGQP-KHLLLVDPEGVVRTKDHRFESVSHLISYHVDNHLPIISAG--- 429

Query: 298 ETSLNLIRPVPC 309
            + L L +PV  
Sbjct: 430 -SELCLQQPVER 440


>UniRef50_Q6NPB1 RH57813p n=16 Tax=Neoptera RepID=Q6NPB1_DROME
          Length = 409

 Score =  177 bits (448), Expect = 5e-43,   Method: Composition-based stats.
 Identities = 78/381 (20%), Positives = 125/381 (32%), Gaps = 84/381 (22%)

Query: 10  EELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINPVVS 69
           + +   GV+ +  Y G V V  S+  +  E R Q+  ECI  V    G+ +A +    ++
Sbjct: 25  DVIMGVGVAFNVRYTGCVEVKTSMKSLDFETRTQLARECINRVCEAAGLKSAGKRR--LT 82

Query: 70  RVIGEVK---KENFPVDINI---------------------------SSKMIKIIKQSRL 99
             I +          + IN+                           S      +     
Sbjct: 83  NFISDRPSMQHAGTNIIINVSSRALSLSNVETGEVIANHNMPRISFASGGDNDTLDFLAY 142

Query: 100 IQRHPFSF----FSFGAQGQKGTDTELMFGYIAKNKDGTDR------------RCHVVFI 143
           I ++   +        A GQ       +    A   +   R             C     
Sbjct: 143 IAKNEDEWRACYVLECAGGQSEDLIVTIGKAFALRFNALSRLNDPSADCNINQSCKENVK 202

Query: 144 EDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVT 203
           E  + L + L   +              +          + R  L       N   P  T
Sbjct: 203 EYYNDLPNKLPPEVPEPQQQQVQQPLHPHAPRVAQLNLKKPRDRLSSNLIDLNSPPPDQT 262

Query: 204 E-------------------------------DVVGKVWYHGNLSREDAQALLKTEGDFL 232
                                            +  +VW+H  +SR  ++ LL+ +GDFL
Sbjct: 263 TNKLGHFDPLQATTAANSVLPSVRDVFDGPQCPLTAEVWFHAGISRPISERLLQQDGDFL 322

Query: 233 VRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRS 292
           VR+S    G+YVL+G       KHL+L+D    VRT+DR F +IS LI+YH  + + + S
Sbjct: 323 VRESQGKRGQYVLTGL-EGKTPKHLLLIDPEGVVRTKDRIFDSISHLINYHWAHALPIIS 381

Query: 293 EGRDRETSLNLIRPVPCPGSD 313
           E    ++ L L  P   P  D
Sbjct: 382 E----DSELVLRNPARRPQQD 398


>UniRef50_Q3ZAX3 Shc3 protein n=9 Tax=Euteleostomi RepID=Q3ZAX3_MOUSE
          Length = 341

 Score =  156 bits (395), Expect = 8e-37,   Method: Composition-based stats.
 Identities = 39/209 (18%), Positives = 75/209 (35%), Gaps = 17/209 (8%)

Query: 6   PSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV-----GVTA 60
           P  ++++   GV+    YLG + V+ S+  +    R QV  E I  V   V      +  
Sbjct: 22  PHTSDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQVTREAISRVCEAVPGAKGALKK 81

Query: 61  AREINPVVSRVIGE--VKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQK 116
            +  + ++S ++G+  ++     + + IS+  + +      ++I  H     SF + G  
Sbjct: 82  RKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDP 141

Query: 117 GTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFT 176
             DT     Y+AK+     R CH++  E    L   +  +I    F+ +          +
Sbjct: 142 --DTTDYVAYVAKDP-VNRRACHIL--ECCDGLAQDVIGSIG-QAFELRFKQYLQC--PS 193

Query: 177 VPAPPMRHRSSLHRQSFVSNCRAPTVTED 205
                     SL           P     
Sbjct: 194 KVPALQDRMQSLDEPWTEEEGDGPDHPYY 222


>UniRef50_UPI0000ECC29C SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2
           domain-containing-transforming protein C3) (Neuronal
           Shc) (N-Shc) (Protein Rai). n=15 Tax=Euteleostomi
           RepID=UPI0000ECC29C
          Length = 582

 Score =  156 bits (393), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 40/189 (21%), Positives = 77/189 (40%), Gaps = 16/189 (8%)

Query: 7   SFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV-----GVTAA 61
             +E++   GV+    YLG + V+ S+  +    R Q+  E I  V   V          
Sbjct: 144 HLSEKILGPGVTYIVKYLGCIEVLRSMRSLDFNTRTQITREAISRVCEAVPGAKGAFKKR 203

Query: 62  REINPVVSRVIGE--VKKENFPVDINISSKMIKII--KQSRLIQRHPFSFFSFGAQGQKG 117
           +  + V+S ++G+  ++     + +NIS+  + ++     ++I  H     SF + G   
Sbjct: 204 KPPSKVLSSILGKSNLQFAGISIMLNISTTSLNLMTPDMKQIIANHHMQSISFASGGDP- 262

Query: 118 TDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTV 177
            DT     Y+AK+     R CH++  E  + L   + + I    F+ +           +
Sbjct: 263 -DTTDYVAYVAKDP-VNRRACHIL--ECCNGLAQDVISTIG-QAFELRFKQYLQ-CPSKM 316

Query: 178 PAPPMRHRS 186
           P    R +S
Sbjct: 317 PTFHDRMQS 325



 Score =  116 bits (289), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 45/102 (44%), Positives = 63/102 (61%), Gaps = 5/102 (4%)

Query: 208 GKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
            K WY G +SR++A+ LLK  GDFLVR+S   PG YVL+G     + KHL+L+D    VR
Sbjct: 484 EKPWYQGEMSRKEAEQLLKKCGDFLVRKSTTNPGSYVLTGM-QNGQAKHLLLVDPEGTVR 542

Query: 268 TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           T+DR F +IS LI++H+ N + + S G    + L L +P   
Sbjct: 543 TKDRVFDSISHLINHHLENNLPIVSSG----SKLCLQQPAER 580


>UniRef50_Q92529 SHC-transforming protein 3 n=21 Tax=Euteleostomi RepID=SHC3_HUMAN
          Length = 594

 Score =  154 bits (390), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 40/236 (16%), Positives = 81/236 (34%), Gaps = 30/236 (12%)

Query: 6   PSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV-----GVTA 60
           P  ++++   GV+    YLG + V+ S+  +    R Q+  E I  V   V         
Sbjct: 142 PHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKK 201

Query: 61  AREINPVVSRVIGE--VKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQK 116
            +  + ++S ++G+  ++     + + IS+  + +      ++I  H     SF + G  
Sbjct: 202 RKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDP 261

Query: 117 GTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFT 176
             DT     Y+AK+     R CH++  E    L   +  +I    F+ +           
Sbjct: 262 --DTTDYVAYVAKDP-VNRRACHIL--ECCDGLAQDVIGSIG-QAFELRFKQYLQCP--- 312

Query: 177 VPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFL 232
              P +  R     + +       +                     + +   G FL
Sbjct: 313 TKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIP------------SKMPPPGGFL 356



 Score =  121 bits (303), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 49/166 (29%), Positives = 86/166 (51%), Gaps = 7/166 (4%)

Query: 146 VHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP--TVT 203
                  +++A +    D        +     P  P+  +++        + RAP   + 
Sbjct: 432 PQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKML 491

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           E++  + WY G +SR++A+ LL+ +GDFLVR+S   PG +VL+G     + KHL+L+D  
Sbjct: 492 EELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHN-GQAKHLLLVDPE 550

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             +RT+DR F +IS LI++H+ + + + S G    + L L +PV  
Sbjct: 551 GTIRTKDRVFDSISHLINHHLESSLPIVSAG----SELCLQQPVER 592


>UniRef50_P98077 SHC-transforming protein 2 n=5 Tax=Tetrapoda RepID=SHC2_HUMAN
          Length = 582

 Score =  152 bits (383), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 40/207 (19%), Positives = 73/207 (35%), Gaps = 15/207 (7%)

Query: 7   SFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV----GVTAAR 62
                +   GVS    Y+G + V+ S+  +    R QV  E I  +   V    G    +
Sbjct: 141 HPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKK 200

Query: 63  EINPVVSRVIGE--VKKENFPVDINISS--KMIKIIKQSRLIQRHPFSFFSFGAQGQKGT 118
             N  ++ V+G+  ++     + I+IS+    + +    ++I  H     SF + G   T
Sbjct: 201 APNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGD--T 258

Query: 119 DTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVP 178
           D      Y+AK+     R CH++  E    L   + + +    F+ +      +    V 
Sbjct: 259 DMTDYVAYVAKDPI-NQRACHIL--ECCEGLAQSIISTVG-QAFELRFKQYL-HSPPKVA 313

Query: 179 APPMRHRSSLHRQSFVSNCRAPTVTED 205
            PP R                     +
Sbjct: 314 LPPERLAGPEESAWGDEEDSLEHNYYN 340



 Score =  120 bits (301), Expect = 7e-26,   Method: Composition-based stats.
 Identities = 53/226 (23%), Positives = 84/226 (37%), Gaps = 9/226 (3%)

Query: 87  SSKMIKIIKQSRLIQRHP---FSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFI 143
               +  + Q             +           D  +                +   +
Sbjct: 361 QPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGL 420

Query: 144 EDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVT 203
           +             ++  F+        +    V A P+                AP   
Sbjct: 421 DAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAP-TE 479

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           E +  + WYHG +SR  A+ +L+ +GDFLVR S   PG+YVL+G  A    KHL+L+D  
Sbjct: 480 EQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQP-KHLLLVDPE 538

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             VRT+D  F +IS LID+H+ NG  + +     E+ L+L   V  
Sbjct: 539 GVVRTKDVLFESISHLIDHHLQNGQPIVAA----ESELHLRGVVSR 580


>UniRef50_Q8BMC3 SHC-transforming protein 2 n=12 Tax=Euteleostomi RepID=SHC2_MOUSE
          Length = 573

 Score =  151 bits (382), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 40/207 (19%), Positives = 74/207 (35%), Gaps = 15/207 (7%)

Query: 7   SFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV----GVTAAR 62
                +   GVS    Y+G + V+ S+  +    R QV  E I  +   V    G    +
Sbjct: 119 HPDARVLGPGVSYIVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKK 178

Query: 63  EINPVVSRVIGE--VKKENFPVDINIS--SKMIKIIKQSRLIQRHPFSFFSFGAQGQKGT 118
             N  ++ ++G+  ++     + +NIS     + +    ++I  H     SF + G   T
Sbjct: 179 APNKALASILGKSNLRFAGMSISVNISVDGLNLSVPATRQIIANHHMQSISFASGGD--T 236

Query: 119 DTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVP 178
           D      Y+AK+     R CH++  E    L   + + +    F+ +      +    V 
Sbjct: 237 DMTDYVAYVAKDPI-NQRACHIL--ECCEGLAQSVISTVG-QAFELRFKQYLHSPPKAV- 291

Query: 179 APPMRHRSSLHRQSFVSNCRAPTVTED 205
            PP R            +  A     +
Sbjct: 292 VPPERLTGLEELAWGDDDAAADHNYYN 318



 Score =  124 bits (310), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 55/167 (32%), Positives = 80/167 (47%), Gaps = 12/167 (7%)

Query: 145 DVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP--TV 202
                       +       + +A +   G T  +PP+  +            RAP    
Sbjct: 415 QFEDSPKKDLFDMRPFEDALKLHACSVAAGITAASPPLEDQWP-----SPPTRRAPIAPT 469

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
            E +  + WYHG +SR  A+ LL+ +GDFLVR S   PG+YVL+G  A    KHL+L+D 
Sbjct: 470 EEQLRQEPWYHGRMSRRAAEKLLRADGDFLVRDSVTNPGQYVLTGMHAGQP-KHLLLVDP 528

Query: 263 HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
              VRT+D  F +IS LIDYH+ NG+ + +     E+ L+L   V  
Sbjct: 529 EGVVRTKDVLFESISHLIDYHLKNGLPIVAA----ESELHLRGVVSR 571


>UniRef50_Q6S5L8 SHC-transforming protein 4 n=49 Tax=Euteleostomi RepID=SHC4_HUMAN
          Length = 630

 Score =  150 bits (378), Expect = 7e-35,   Method: Composition-based stats.
 Identities = 40/199 (20%), Positives = 76/199 (38%), Gaps = 15/199 (7%)

Query: 5   EPSFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV----GVTA 60
           +  F + L   G++    Y+G V V++S+  +   MR QV  E I  +   V    G   
Sbjct: 178 DRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIK 237

Query: 61  AREINPV-VSRVIGE--VKKENFPVDINISSKMIKIIK--QSRLIQRHPFSFFSFGAQGQ 115
            R+     +S V+G+  ++     + + IS+  + ++     ++I  H     SF + G 
Sbjct: 238 KRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGD 297

Query: 116 KGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGF 175
              DT     Y+AK+     R CH++  E  + +   + + I    F+ +      N   
Sbjct: 298 P--DTTDYVAYVAKDP-VNQRACHIL--ECHNGMAQDVISTIG-QAFELRFKQYLKNPSL 351

Query: 176 TVPAPPMRHRSSLHRQSFV 194
                        H +   
Sbjct: 352 NTSCESEEVHIDSHAEERE 370



 Score =  134 bits (338), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 53/195 (27%), Positives = 88/195 (45%), Gaps = 12/195 (6%)

Query: 124 FGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPP-- 181
            G +      + R   ++       L D     IN     +   ++ +         P  
Sbjct: 434 IGNVHPRGVQSQRDTSLLKHTCRVDLFDDP-CYINTQALQSTPGSAGNQRSAQPLGSPWH 492

Query: 182 ----MRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSD 237
                            S+   P + + +  +  YHG LSR+ A++LL  +GDFLVR+S 
Sbjct: 493 CGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESA 552

Query: 238 HTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
            +PG+YVLSG     + KHL+L+D   +VRT+D  F N+  LI YH++N + + S G   
Sbjct: 553 TSPGQYVLSGL-QGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSG--- 608

Query: 298 ETSLNLIRPVPCPGS 312
            + ++L +PV    +
Sbjct: 609 -SEVSLKQPVRKDNN 622


>UniRef50_P16591 Tyrosine-protein kinase Fer n=54 Tax=root RepID=FER_HUMAN
          Length = 822

 Score =  150 bits (378), Expect = 8e-35,   Method: Composition-based stats.
 Identities = 46/261 (17%), Positives = 98/261 (37%), Gaps = 38/261 (14%)

Query: 78  ENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDT----ELMFGYIAKNKDG 133
               + + + +   ++++  +++     +      + ++ ++T      +   +++ +  
Sbjct: 301 TAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQAL 360

Query: 134 TDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSF 193
            + +  V  +             +       Q N               R  +S+ R+  
Sbjct: 361 EELKQSVQQLRCTEAKFSAQKELLEQ---KVQENDGKEPPPVVNYEEDARSVTSMERKER 417

Query: 194 VSNCRA-------------------------PTVTEDVVGKVWYHGNLSREDAQALLKTE 228
           +S   +                             + +  + WYHG + R +AQ LLK +
Sbjct: 418 LSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQ 477

Query: 229 GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGM 288
           GDFLVR+S   PG+YVLS   ++ + +H I+    N  R     FSNI +LID+H     
Sbjct: 478 GDFLVRESHGKPGEYVLSV-YSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQ 536

Query: 289 AVRSEGRDRETSLNLIRPVPC 309
            +       ++ + L+ P+P 
Sbjct: 537 VITK-----KSGVVLLNPIPK 552


>UniRef50_B4IYA5 GH15138 n=5 Tax=Drosophila RepID=B4IYA5_DROGR
          Length = 442

 Score =  150 bits (378), Expect = 8e-35,   Method: Composition-based stats.
 Identities = 49/246 (19%), Positives = 89/246 (36%), Gaps = 23/246 (9%)

Query: 10  EELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVT--AAREINPV 67
           + +   GV+ +  Y G V V  S+  +  E R  +  ECI  V    G+   + R ++  
Sbjct: 27  DIILEKGVTFNVRYTGCVEVKTSMKSLDFETRTLLARECINRVCEAAGLKSASKRRLDKK 86

Query: 68  VSRVIGEVK---KENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTEL 122
           +   I +          + IN+SS+ + +  ++   +I  H     SF + G    DT  
Sbjct: 87  LHNFISDRPSMQHAGTNIIINVSSRALTLSNVETGEVIASHNMPRISFASGGD--NDTLD 144

Query: 123 MFGYIAKNKDGTDRRCHVVFI--EDVHKLIDVLT-------TAINVNTFDAQANASTSND 173
              YIAK +    R C+V+         LI  +         A++       + A+  N 
Sbjct: 145 FLAYIAKREGDEWRACYVLECGGGQSEDLIVTIGKAFVLRFNALSRQNDHLASAAAAENM 204

Query: 174 GFTVPAPPMRHRSSLHRQSFVS-NCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFL 232
             +       + + L  +             +   G++  H +  R  AQ  L+   D  
Sbjct: 205 NQSCKENVKEYYNDLPNKLPPELPFEEQHEQQQQPGQLPLHPHAPR-VAQLNLRKPRD-- 261

Query: 233 VRQSDH 238
            R S +
Sbjct: 262 -RLSSN 266



 Score =  124 bits (312), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 43/112 (38%), Positives = 69/112 (61%), Gaps = 5/112 (4%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
            +  +VW+H  +SR  ++ LL+ +GDFLVR+S    G+YVL+G       KHL+L+D   
Sbjct: 327 PLTAEVWFHAAISRPISERLLQQDGDFLVRESQGKRGQYVLTGL-EGKAPKHLLLIDPEG 385

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDDIE 316
            VRT+DR F +IS LI+YH  + + + SE    ++ L L  PV  P +++++
Sbjct: 386 VVRTKDRIFDSISHLINYHWVHALPIISE----DSELVLRNPVRRPANNNLD 433


>UniRef50_O14492 SH2B adapter protein 2 n=4 Tax=Catarrhini RepID=SH2B2_HUMAN
          Length = 632

 Score =  145 bits (366), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 42/275 (15%), Positives = 90/275 (32%), Gaps = 36/275 (13%)

Query: 58  VTAAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKG 117
               +   P VS  +  + +    + + +  K    + +      +           QK 
Sbjct: 239 FVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETID---SLQKH 295

Query: 118 TDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTV 177
           +    + G +       D          +   +   +  +  +  D      T+  G  V
Sbjct: 296 SWVADIQGCVDPGDSEEDTELSCTRGGCLASRVASCSCELLTDAVDLPRPPETTAVGAVV 355

Query: 178 PAPPMRHRSSLHR-------QSFVSNCRAP---------------------TVTEDVVGK 209
            AP  R R ++         ++F+    +P                         ++   
Sbjct: 356 TAPHSRGRDAVRESLIHVPLETFLQTLESPGGSGSDSNNTGEQGAETDPEAEPELELSDY 415

Query: 210 VWYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
            W+HG LSR  A  L+     +  G F++RQS+  PG+YVL+           + L+ H 
Sbjct: 416 PWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHG 475

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
           +   +   F ++ +++ +   + + + S G    T
Sbjct: 476 QCHVQHLWFQSVLDMLRHFHTHPIPLESGGSADIT 510


>UniRef50_A7RR81 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7RR81_NEMVE
          Length = 473

 Score =  145 bits (365), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 46/181 (25%), Positives = 71/181 (39%), Gaps = 13/181 (7%)

Query: 7   SFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINP 66
                LR  GV  +  Y+G + V +S+  +  E+R QV  E I       G    +   P
Sbjct: 30  HSEGSLREGGVCYAVKYVGCLSVEKSMRTLPYEVRQQVTREAILRCCEAAGYPLPKRKKP 89

Query: 67  --VVSRVIGEVKKENF---PVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTD 119
              VSR++GE    N     V++ IS+  +K+  +   R I  H     SF + G+K  D
Sbjct: 90  HKNVSRILGETPNMNHSGTNVNLTISATGMKMVDMNNGRRIANHDMQGISFASGGEK--D 147

Query: 120 TELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPA 179
              M GY+AK++    R CHV         +           F+ +      N    +  
Sbjct: 148 CVNMVGYVAKDE-VNGRACHVCDCGGE---LAYDVINTVGQAFEIRFKMFLQNPPQAMEV 203

Query: 180 P 180
           P
Sbjct: 204 P 204



 Score =  121 bits (304), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 59/245 (24%), Positives = 100/245 (40%), Gaps = 21/245 (8%)

Query: 72  IGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQG--QKGTDTEL-MFGYIA 128
           + ++    + V        + +         +P     F A        D +    G+  
Sbjct: 242 LPKIPGSGYAVPFARPDSGLDL---------NPRESLDFAAGAMYDNPEDPDDGRLGFYN 292

Query: 129 KNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSL 188
               G      +    D     D +    N  T  +     T      +      + +  
Sbjct: 293 NPLAGASTDPRLPARMDSLSRDDDIPEYHNPETRFSSPPQPTHAPKNLMDDDIPEYHNPE 352

Query: 189 HRQSFVSNCRAPTVTE----DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYV 244
            + S   +  AP  +      +  K WYHG +SR +A+ LL+ EGDFLVR+S   PG+YV
Sbjct: 353 TQFSLPLSVHAPVASTRSSSFMRAKDWYHGPISRGEAELLLEDEGDFLVRESKSQPGQYV 412

Query: 245 LSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
           LSG   + + +HL+L+D   +VRTRD+ F N+ +LI +H+ N + + S G    + + + 
Sbjct: 413 LSGI-KDKQARHLLLVDPQGQVRTRDKVFENVDQLISFHLVNQVPIISAG----SEVTIK 467

Query: 305 RPVPC 309
            PV  
Sbjct: 468 HPVLR 472


>UniRef50_UPI000180D2C5 PREDICTED: similar to SHC (Src homology 2 domain containing)
           transforming protein 1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180D2C5
          Length = 497

 Score =  144 bits (364), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 48/214 (22%), Positives = 78/214 (36%), Gaps = 21/214 (9%)

Query: 7   SFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA------ 60
                +   GV  S  YLG V V +S+  +  +MR     E I  V A+ G++       
Sbjct: 33  HPDSSVMGPGVVYSVQYLGCVEVRQSMRTLDFDMRTLATKEAIWRVLASTGMSPLPPAAN 92

Query: 61  ---AREINPVVSRVIGEVKKENFP---VDINISSKMIKII--KQSRLIQRHPFSFFSFGA 112
               ++    V+R++GE     F    +++ IS+  + ++     + I  H     SF +
Sbjct: 93  RSGRKKPPKDVTRILGERPNLKFSQSFINLTISTASLTLVVSNTGQFIANHQMQSISFAS 152

Query: 113 QGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSN 172
            G    DT     Y+AK+     R CHV+   D   L   +   I    F+ +      N
Sbjct: 153 GGDP--DTIDYVAYVAKDPI-NSRACHVLKCTD--GLAQDVINTIG-QAFELRFKEYLKN 206

Query: 173 DGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDV 206
               V  PP R     H          P    ++
Sbjct: 207 PPKAV-TPPDRTEPLFHDGKSRWGDDEPEYYNEI 239



 Score =  119 bits (297), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 50/200 (25%), Positives = 84/200 (42%), Gaps = 10/200 (5%)

Query: 116 KGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGF 175
           +  +                    V  +        +     +         A+      
Sbjct: 300 RNFEDHNYVNTCVMPHGQEATPASVRPMASPQPTPVMSHELSSGGGGALAIAAAIGVSRE 359

Query: 176 TVPAPPMRHRSSLHRQSFVSNCRAPTVTED-----VVGKVWYHGNLSREDAQALLKTEGD 230
             P    R           +N   P  T       +  K W+HG+++R++A+ LL  +GD
Sbjct: 360 HTPTNQKRPSVDAFDMRPFANTLNPPATPTSATNALQSKPWFHGHVTRKEAEQLLSHDGD 419

Query: 231 FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           FLVR+S  T G++VLSG   + ++KHL+L+D +  VRT+DR F ++S LI +H +N + +
Sbjct: 420 FLVRESTTTKGQFVLSG-VQDGQYKHLLLVDPNGVVRTKDRQFDSVSHLISFHRDNTLPI 478

Query: 291 RSEGRDRETSLNLIRPVPCP 310
            S G    + L L +PV   
Sbjct: 479 VSSG----SVLLLRQPVTRQ 494


>UniRef50_B7Q1P4 Shc transforming protein, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7Q1P4_IXOSC
          Length = 461

 Score =  141 bits (355), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 42/209 (20%), Positives = 77/209 (36%), Gaps = 15/209 (7%)

Query: 7   SFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA---ARE 63
              +E+   GV+    Y+G + V  S+  +  + R  +  ECI  V    G+ A    R+
Sbjct: 10  HTDQEVLGLGVTYRVRYIGCLDVKMSMKCLDFDTRSLIAKECITRVCEAAGLKAVDKKRK 69

Query: 64  INPVVSRVIGEVKK---ENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGT 118
           ++  + R++ E          V++ ++S  +K+  ++  + I  H     SF + G    
Sbjct: 70  VDRRLQRMLAERPNMDYAGSNVNLCVTSSSLKLSILETGQAIADHNMPNISFASGGD--A 127

Query: 119 DTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVP 178
           +T     Y+AK+  G  R C V+       L   + T I    F+ +            P
Sbjct: 128 ETLDFVAYVAKDGQG-ARACLVLECGG--GLAQDVITTIG-QAFELRFREFMRGVPAPPP 183

Query: 179 AP-PMRHRSSLHRQSFVSNCRAPTVTEDV 206
            P  +  R              P    D+
Sbjct: 184 LPSLVPRRCVGSSPLRAGRSDDPEYYNDL 212



 Score =  119 bits (299), Expect = 9e-26,   Method: Composition-based stats.
 Identities = 42/105 (40%), Positives = 69/105 (65%), Gaps = 5/105 (4%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
           +  + W+HG +SR++++  L  +GDFLVR+S   PG++VL+G    +  +HL+L+D    
Sbjct: 361 LEKEAWFHGAISRKESEGRLAEDGDFLVRESQGNPGQFVLTGM-QGSARRHLLLVDPAGV 419

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
           VRT+DRTF ++S L++YH +N + + S     E++L L  PVP P
Sbjct: 420 VRTKDRTFDSVSHLVNYHRDNALPIISA----ESALVLKNPVPRP 460


>UniRef50_Q9JID9 SH2B adapter protein 2 n=13 Tax=Euteleostomi RepID=SH2B2_MOUSE
          Length = 621

 Score =  139 bits (349), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 42/274 (15%), Positives = 88/274 (32%), Gaps = 35/274 (12%)

Query: 58  VTAAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKG 117
               +   P VS  +  + +    + + +  K    + +      +           QK 
Sbjct: 232 FVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETID---SLQKH 288

Query: 118 TDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTV 177
           +    + G +       D          +   +   +  +  +    +   +T+  G  V
Sbjct: 289 SWVADIQGCVDPGDSEEDTGLSCARGGCLASRVASCSCELLTDADMPRPPETTTAVGAVV 348

Query: 178 PAPPMRHR----------------SSLHRQSFVSNCRAP-----------TVTEDVVGKV 210
            AP  R R                 +L     VS    P               ++    
Sbjct: 349 TAPHGRARDTVGESLAHVPLETFLQTLESSGGVSENNNPGDEGAELDTDAEAELELSDYP 408

Query: 211 WYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
           W+HG LSR  A  L+     ++ G F++RQS+  PG+ VL+           + L+ H +
Sbjct: 409 WFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQ 468

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
              +   F ++ +++ +   + + + S G    T
Sbjct: 469 CHVQHLWFQSVFDMLRHFHTHPIPLESGGSADIT 502


>UniRef50_P18106-3 Isoform C of Tyrosine-protein kinase Fps85D n=4 Tax=Endopterygota
           RepID=P18106-3
          Length = 475

 Score =  137 bits (344), Expect = 7e-31,   Method: Composition-based stats.
 Identities = 54/227 (23%), Positives = 93/227 (40%), Gaps = 23/227 (10%)

Query: 89  KMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHK 148
           KMI+ +     +     S  S G+    G  +        ++KD    RC     +   K
Sbjct: 2   KMIEHVNGGSPVANG--SIISNGSNTSNGIQS-NKDSLCRQSKDLNALRCQE---KQKQK 55

Query: 149 LIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVG 208
           L+D++  A+N      +   S  +D  T+    + +  +  +Q  +S  R       +  
Sbjct: 56  LVDMIKCALN--EVGCEELPSGCDDDLTLEQNFIENGYNNEQQISLSTNRP------LYE 107

Query: 209 KVWYHGNLSREDAQALLKTEGDFLVRQS-DHTPGKYVLSGRTAENEHKHLILLDN-HNRV 266
           + W+HG L RE+   LL  +GDFLVR++  +   + VLS       HKH I+        
Sbjct: 108 EEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNG--HKHFIVQTTGEGNF 165

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           R     F++I ELI +  ++ + V       ++   L RPV     +
Sbjct: 166 RFEGPPFASIQELIMHQYHSELPVT-----VKSGAILRRPVCRERWE 207


>UniRef50_UPI000051A29D PREDICTED: similar to SHC-adaptor protein CG3715-PA n=2
           Tax=Apocrita RepID=UPI000051A29D
          Length = 443

 Score =  135 bits (340), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 37/175 (21%), Positives = 69/175 (39%), Gaps = 14/175 (8%)

Query: 12  LRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTA---AREINPVV 68
           +   G++ +  Y+G + V  S+  +  E R  V  ECI  V    G+ +    R ++  V
Sbjct: 23  VSKEGITYTVKYIGCLEVYTSMKSLDFETRSCVAKECINRVCEAAGLKSADKKRRVDRKV 82

Query: 69  SRVIGE---VKKENFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFGAQGQKGTDTELM 123
            R I +   ++     +++ ISS  + +  I+   +I +H     SF + G         
Sbjct: 83  LRAIADKPRMEHTGATINLTISSCSLALTNIENGHIIAKHEMPRISFASGGDTEI--LDF 140

Query: 124 FGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVP 178
             Y+AKN     R C+V+       L   + + I    F+ +     +      P
Sbjct: 141 VAYVAKNM-QEWRACYVLECGG--GLAQDVISTIG-QAFELRFKEFLTKPASLHP 191



 Score =  124 bits (311), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 49/213 (23%), Positives = 95/213 (44%), Gaps = 6/213 (2%)

Query: 102 RHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNT 161
            H        +  Q     +       ++        +++ +       +      +   
Sbjct: 236 HHSVQNHISRSNIQNSGLHDTFSISSDRHHQQWAETGNLIDLNSDGTSTNFNIPPEHNYV 295

Query: 162 FDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP-TVTEDVVGKVWYHGNLSRED 220
            D+   AS  N         +             N  +P +  + +  ++W+HG++SR +
Sbjct: 296 NDSVIAASRENQRDQTSLFDVFDMQPFSSAISDMNKLSPHSQKQQLKQEIWFHGSVSRAE 355

Query: 221 AQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELI 280
           A+++L  +GDFLVR+S  +PG+YVL+G    N  KHL+L+D    VRT+DR F ++S L+
Sbjct: 356 AESMLTRDGDFLVRESQGSPGQYVLTGM-NNNTPKHLLLIDPEGVVRTKDRVFDSVSHLV 414

Query: 281 DYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           ++H +N + + S     ++ L L  P+P   ++
Sbjct: 415 NHHCDNVLPIISA----DSVLVLRYPIPRRTNN 443


>UniRef50_A9V8S2 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V8S2_MONBE
          Length = 1027

 Score =  134 bits (338), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 45/301 (14%), Positives = 83/301 (27%), Gaps = 26/301 (8%)

Query: 26  SVPVVESINVMVSEMRVQVVSECI-----------QHVAATVGVTAAREINPVVSRVIGE 74
           S+  V+S  V  SE + +                   V    G      I   V  +  +
Sbjct: 664 SLKAVQSRRVPRSETQSRTSRNATISVRSGHTVAPFQVPGAAGALTEEPIPEGVHNLAAK 723

Query: 75  VKKENFPVDI---NISSKMIKIIKQSRLI-QRHPFSFFSFGAQGQKGTDTELMFGYIAKN 130
           + + +        ++       +    ++   H F        G            +   
Sbjct: 724 MGRASLDSSAGGSSVQPTATANMAPGDILEAVHSFEHHRERQAGDLAFKRGDYVKVLESA 783

Query: 131 KDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSN--DGFTVPAPPMRHRSSL 188
                R  H+  +E     I+         T          N   G     PP R   S 
Sbjct: 784 PGNWWRGQHMGTMEQGLIPINFFRKPDRRMTHVGHNMTPPLNLDGGSGTAPPPPRPPKSA 843

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLS 246
             +      +          + WY G + + +A        +G F VR      G Y L 
Sbjct: 844 TVRGLSMQRKQGLRAFMPEFEYWYLGPMDKPEAHQRFVGLPQGSFGVR-RTPDKGAYRLV 902

Query: 247 GRTAENEHKHLILLDNHNRVRTR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
            +  +   KHL +   +N+       TF  I +L+ ++ +  +         +    L+ 
Sbjct: 903 VKFGQ-TVKHLRIHAANNQYMLGMAATFDTIPQLVKHYRHQSL----ASHYEDLDTTLLI 957

Query: 306 P 306
           P
Sbjct: 958 P 958


>UniRef50_Q6S5L8-2 Isoform 2 of SHC-transforming protein 4 n=4 Tax=Eutheria
           RepID=Q6S5L8-2
          Length = 387

 Score =  134 bits (337), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 53/195 (27%), Positives = 88/195 (45%), Gaps = 12/195 (6%)

Query: 124 FGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPP-- 181
            G +      + R   ++       L D     IN     +   ++ +         P  
Sbjct: 191 IGNVHPRGVQSQRDTSLLKHTCRVDLFDDP-CYINTQALQSTPGSAGNQRSAQPLGSPWH 249

Query: 182 ----MRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSD 237
                            S+   P + + +  +  YHG LSR+ A++LL  +GDFLVR+S 
Sbjct: 250 CGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESA 309

Query: 238 HTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
            +PG+YVLSG     + KHL+L+D   +VRT+D  F N+  LI YH++N + + S G   
Sbjct: 310 TSPGQYVLSGL-QGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSG--- 365

Query: 298 ETSLNLIRPVPCPGS 312
            + ++L +PV    +
Sbjct: 366 -SEVSLKQPVRKDNN 379



 Score = 57.5 bits (137), Expect = 6e-07,   Method: Composition-based stats.
 Identities = 18/97 (18%), Positives = 31/97 (31%), Gaps = 6/97 (6%)

Query: 98  RLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAI 157
            +I  H     SF + G    DT     Y+AK+     R CH++  E  + +   + + I
Sbjct: 37  HIIANHHMQSISFASGGDP--DTTDYVAYVAKDP-VNQRACHIL--ECHNGMAQDVISTI 91

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFV 194
               F+ +      N                H +   
Sbjct: 92  G-QAFELRFKQYLKNPSLNTSCESEEVHIDSHAEERE 127


>UniRef50_B7PSP3 Tyrosine protein kinase, putative (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7PSP3_IXOSC
          Length = 674

 Score =  131 bits (330), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 48/283 (16%), Positives = 93/283 (32%), Gaps = 26/283 (9%)

Query: 41  RVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLI 100
           +  V  E I      V    +R  +          KK N  +D   S       +    I
Sbjct: 144 QQTVQQEAID-CWQAVMRDYSRHTDFCSEAFQSVHKKLNESIDFIKSES-----EYQDFI 197

Query: 101 QRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVN 160
           +++               D  L+  Y+ K K           I+ + +   V   A+++ 
Sbjct: 198 EKYKSKPIPPI---DFHYDESLLNNYVGKLK-PEQIAVDEFTIDALRERAMVKKRAVDII 253

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQ---------SFVSNCRAPTVTEDVVGKVW 211
             +            +     ++  SS+  +         +      +      +  + W
Sbjct: 254 RRERDEIKCQEERINSQLQLLVQPLSSIGSEVPRGLDLDITVNGEQMSVNPNVVLQDEDW 313

Query: 212 YHGNLSREDAQALLKTEGDFLVRQS-DHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD 270
           +HG L RE+   LL   GD+LVR++  +   + VLS    +     ++   +  + R   
Sbjct: 314 FHGVLPREEVVRLLVNNGDYLVRETMRNEEKQVVLSVCW-QGHKHFIVQTTSDGKYRFEG 372

Query: 271 RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
             F  + ELI Y  + G+ V S     ++   L  P+     +
Sbjct: 373 PAFGTVQELIVYQHHLGLPVTS-----KSGAILQNPIFRERWE 410


>UniRef50_Q9Y1Z0 Protein tyrosine kinase n=2 Tax=Metazoa RepID=Q9Y1Z0_9METZ
          Length = 485

 Score =  129 bits (323), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 39/218 (17%), Positives = 67/218 (30%), Gaps = 26/218 (11%)

Query: 97  SRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTA 156
           +  I ++ F      +              +A +KD                L  ++   
Sbjct: 9   TECIGKYNFPG---SSPHDLPFKKGDRLVIVAPSKDPNW-----YKARREDGLEGMI--- 57

Query: 157 INVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNL 216
                   Q     +      P  P+         +  +   A      +    W+HG +
Sbjct: 58  ---PFNYVQEKVPVAGSAPQPPQRPVLSAPQPVADNDAAMNHASKGAVQLKTMPWFHGRI 114

Query: 217 SREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT-RDRTF 273
           SREDA+ LL     G FLVR+S + PG Y L          + +  +    V    D  F
Sbjct: 115 SREDAEKLLTPPKNGRFLVRESQNYPGDYTLCVSYDGRVENYRVRRNEKGLVTVDDDEYF 174

Query: 274 SNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
            N+ +L++++      +            L  PV   G
Sbjct: 175 DNLIKLVEHYQKEADGLC---------TRLKAPVDKEG 203


>UniRef50_P42684 Tyrosine-protein kinase ABL2 n=44 Tax=Euteleostomi RepID=ABL2_HUMAN
          Length = 1182

 Score =  127 bits (318), Expect = 6e-28,   Method: Composition-based stats.
 Identities = 37/155 (23%), Positives = 58/155 (37%), Gaps = 14/155 (9%)

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
             NT            G+         RS   +    SN   P  +  +    WYHG +S
Sbjct: 122 GDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNS--LEKHSWYHGPVS 179

Query: 218 REDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR-VRTRDRTFS 274
           R  A+ LL +   G FLVR+S+ +PG+  +S R     + + I      +   T +  FS
Sbjct: 180 RSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFS 239

Query: 275 NISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            ++EL+ +H      +            L  P P 
Sbjct: 240 TLAELVHHHSTVADGLV---------TTLHYPAPK 265


>UniRef50_UPI000186ED21 tyrosine-protein kinase shark, putative n=1 Tax=Pediculus humanus
           corporis RepID=UPI000186ED21
          Length = 751

 Score =  127 bits (318), Expect = 7e-28,   Method: Composition-based stats.
 Identities = 44/272 (16%), Positives = 77/272 (28%), Gaps = 27/272 (9%)

Query: 36  MVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENFPVDINISSKM----- 90
              + R    +  +         T   E+     R      ++        S K      
Sbjct: 106 PPHDTRCHGKTNLLHRATKEGNYTVVSELLKCGYRNTDAKSEDGQTAAHLASRKGADDIL 165

Query: 91  IKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDG--------TDRRCHVVF 142
           IK+I+    I     + ++      +      +   I K +               H   
Sbjct: 166 IKLIETGANINCRDTAGYTPLHYACQSNHLTTIRLLIQKGEAQVQSRNANTGWVPLHEAA 225

Query: 143 IEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTV 202
              + ++I +L             NA           P M  +    +       +    
Sbjct: 226 WRGLSEVIQLL----------LGLNAPAHPRTLEGETPLMLAQRKGFQDCVEILRKYKAP 275

Query: 203 TEDVVGKVWYHGNLSREDAQALLK----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
              +    WYHG L R++A  LLK     EG +LVR S    G YVL+    +      I
Sbjct: 276 KPVLSKYNWYHGTLDRKEAVELLKEYGNKEGSYLVRYSHKNGGVYVLTMIVNDRSFHFQI 335

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
             +N            ++  +IDY+      +
Sbjct: 336 KNENGYYFIDDGPLLESLEHVIDYYSRMQDGL 367



 Score = 96.0 bits (237), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 29/90 (32%), Positives = 44/90 (48%), Gaps = 5/90 (5%)

Query: 207 VGKVWYHGNLSREDAQAL---LKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
               W+HG LSR+DA+ L   L +EG FLVR+S  +PG +VL+     +   + IL    
Sbjct: 5   ECISWFHGKLSRDDAEKLIQDLNSEGGFLVRESFASPGDFVLTLLHNGDIVHYQILRHGE 64

Query: 264 NRVR--TRDRTFSNISELIDYHVNNGMAVR 291
           +       +  F  +  LI+YH  N   + 
Sbjct: 65  DAFFSIDNEHIFHGLETLINYHQENENGLI 94


>UniRef50_A9V4N6 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V4N6_MONBE
          Length = 363

 Score =  125 bits (314), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 48/202 (23%), Positives = 79/202 (39%), Gaps = 11/202 (5%)

Query: 16  GVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGV--TAAREINPVVSRVIG 73
           G+     YLG +P   S+  M  E R  V  E IQ V+ TVGV     R+  P++ R + 
Sbjct: 34  GIVYPVKYLGKIPFAMSMRTMRFEDRTAVTREAIQLVSETVGVVDPVTRQATPLMKRTLV 93

Query: 74  EVK---KENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKN 130
           E       N  + I+++   I++I+   +I  H     SF   G +   T    GYIAK+
Sbjct: 94  EDPVAMNLNVRLKISVTGLTIQVIETGEIIGTHIVPSISFAT-GDRPN-TYERIGYIAKD 151

Query: 131 KDGTDRRCHVVFIE-DVHKLIDVLTT--AINVNTFDAQANASTSNDGFTVPAPPMRHRSS 187
           +    R CHV       ++++  +     +   +F A+              P  R +  
Sbjct: 152 QRNN-RECHVFDCGSRANEIMVTIGQAFELRYKSFLAKGQRQGMQAHAPPVPPMPRAQHM 210

Query: 188 LHRQSFVSNCRAPTVTEDVVGK 209
             +   V   +AP   +     
Sbjct: 211 PAQYDVVGEEQAPIYDQAFDTH 232


>UniRef50_UPI000069FB4F rai-like protein n=2 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI000069FB4F
          Length = 393

 Score =  125 bits (313), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 35/163 (21%), Positives = 66/163 (40%), Gaps = 15/163 (9%)

Query: 21  ATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATV----GVTAAREINPV-VSRVIGE- 74
             Y+G + V++S+  +    R QV  E I  +   V    G T  R+     +S ++G+ 
Sbjct: 3   LQYMGCIEVLQSMRSLDFGTRTQVTREAISRLCEAVPGAKGATKKRKPPVKFLSSILGKS 62

Query: 75  -VKKENFPVDINISSKM--IKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNK 131
            ++     V ++IS+    +      +++  H     SF + G    DT     Y+AK+ 
Sbjct: 63  NLQFSGMNVQLSISTNSLILTNSDTQQVVANHHMQSISFASGGDP--DTTDYVAYVAKDP 120

Query: 132 DGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDG 174
               R CH+  +E  + L   +  AI    F+ +      +  
Sbjct: 121 -VNQRACHI--MECTNNLAQDVINAIG-QAFELRFKQFLKSPS 159



 Score =  123 bits (309), Expect = 7e-27,   Method: Composition-based stats.
 Identities = 51/288 (17%), Positives = 100/288 (34%), Gaps = 27/288 (9%)

Query: 37  VSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQ 96
               R   + EC  ++A  V     +       + +      +      +          
Sbjct: 120 PVNQRACHIMECTNNLAQDVINAIGQAFELRFKQFLKSPSLIDTNDSAEL---------D 170

Query: 97  SRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTA 156
             ++ +      S     +           +A            +  + +    D   + 
Sbjct: 171 INILAQKNEDKDSHEYYNEIPGKGPSADEVLANRMKTEPMEIKRMSNKHLSFSTDHSASK 230

Query: 157 INVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQ-----------SFVSNCRAPTV--T 203
           +         +     +       P + + S   +              +  + P +   
Sbjct: 231 VLKPQVGGMFDDPCYINTVPKQDNPSKSQISGKNKEICDLLASKKFYSTTEIQEPKLPLY 290

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
             +  + WYHG ++R+ A++LL  +GDFL+R+S  +  +YVLSG       KHL+L+D  
Sbjct: 291 SSLQHEEWYHGKMNRKVAESLLVNDGDFLIRESTTSACQYVLSGL-QGGHPKHLLLVDPD 349

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
            +VRT+D  F ++  LI YH+ N + + S G    + L L +PV    
Sbjct: 350 GKVRTKDHVFESVIHLISYHMENELPIISSG----SELYLRKPVRKQH 393


>UniRef50_UPI0001A5EB2D PREDICTED: hypothetical protein XP_002347924 n=1 Tax=Homo sapiens
           RepID=UPI0001A5EB2D
          Length = 475

 Score =  125 bits (313), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 58/279 (20%), Positives = 96/279 (34%), Gaps = 60/279 (21%)

Query: 23  YLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENFPV 82
           Y+G + V+ S+  +    R QV  +                                  +
Sbjct: 247 YMGCIEVLRSMRSLDFNTRTQVTRDAC-------------------------------SL 275

Query: 83  DINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVF 142
             ++ S          +            A+G    +  L                  + 
Sbjct: 276 PWDVGSTGTAPPGDGYVQAD---------ARGPPDHEEHLYVN------------TQGLD 314

Query: 143 IEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP-- 200
             +           +       + +  +   G T    P+  +            RAP  
Sbjct: 315 APEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWP-----SPPTRRAPVA 369

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
              E +  + WYHG +SR  A+ +L+ +GDFLVR S   PG+YVL+G  A    KHL+L+
Sbjct: 370 PTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQP-KHLLLV 428

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
           D    VRT+D  F +IS LID+H+ NG  + +   +   
Sbjct: 429 DPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHL 467


>UniRef50_Q16XS6 Proto-oncogene tyrosine-protein kinase abl1 n=2 Tax=Culicini
           RepID=Q16XS6_AEDAE
          Length = 1578

 Score =  124 bits (312), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 47/262 (17%), Positives = 82/262 (31%), Gaps = 22/262 (8%)

Query: 62  REINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFG---AQGQKGT 118
           +   P  SR++G          +  S  +  I     +I     +    G     G   +
Sbjct: 40  KSRVPKDSRILGSNIFTEHSEALLQSRPLPHIPPPGSIIPGDVLAQSQDGSENHTGTLHS 99

Query: 119 DTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAI------NVNTFDAQANASTSN 172
                    +            +      +    L  A+        N    +       
Sbjct: 100 QGSSNTAQSSFENAHRWTSKENLLAPGPEEDDPQLFVALYDFKAGGENQLSLRKGEQVRI 159

Query: 173 DGFTVPAPPMRHRS-SLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EG 229
             +          S S H     SN   P  +  +    WYHG +SR  A+ LL +   G
Sbjct: 160 LSYNKSGEWCEAHSDSGHVGWVPSNYVTPLNS--LEKHSWYHGPISRNAAEYLLSSGING 217

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR-VRTRDRTFSNISELIDYHVNNGM 288
            FLVR+S+ +PG+  +S R     + + I  D+  +   T +  F+ ++EL+ +H     
Sbjct: 218 SFLVRESESSPGQRSISLRYDGRVYHYRISEDSDGKVYVTAEAKFNTLAELVHHHSV--- 274

Query: 289 AVRSEGRDRETSLNLIRPVPCP 310
                         L+ P P  
Sbjct: 275 ----LHEGHGLITPLLYPAPKQ 292


>UniRef50_P00522 Tyrosine-protein kinase Abl n=8 Tax=Coelomata RepID=ABL_DROME
          Length = 1620

 Score =  124 bits (310), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 12/130 (9%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPG 241
           H  S +     SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG
Sbjct: 229 HSDSGNVGWVPSNYVTPLNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPG 286

Query: 242 KYVLSGRTAENEHKHLILLDNHNR-VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
           +  +S R     + + I  D   +   T++  F+ ++EL+ +H                 
Sbjct: 287 QRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSV-------PHEGHGLI 339

Query: 301 LNLIRPVPCP 310
             L+ P P  
Sbjct: 340 TPLLYPAPKQ 349


>UniRef50_B4L9R9 GI16710 n=2 Tax=Coelomata RepID=B4L9R9_DROMO
          Length = 1591

 Score =  123 bits (309), Expect = 7e-27,   Method: Composition-based stats.
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 12/130 (9%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPG 241
           H  S +     SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG
Sbjct: 228 HSDSGNVGWVPSNYVTPLNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPG 285

Query: 242 KYVLSGRTAENEHKHLILLDNHNR-VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
           +  +S R     + + I  D   +   T++  F+ ++EL+ +H                 
Sbjct: 286 QRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSV-------PHEGHGLI 338

Query: 301 LNLIRPVPCP 310
             L+ P P  
Sbjct: 339 TPLLYPAPKQ 348


>UniRef50_A2RQD7 Bcr-abl1 e19a2 chimeric protein (Fragment) n=1 Tax=Homo sapiens
           RepID=A2RQD7_HUMAN
          Length = 498

 Score =  123 bits (309), Expect = 8e-27,   Method: Composition-based stats.
 Identities = 33/155 (21%), Positives = 59/155 (38%), Gaps = 14/155 (9%)

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
             NT            G+         ++   +    SN   P  +  +    WYHG +S
Sbjct: 328 GDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNS--LEKHSWYHGPVS 385

Query: 218 REDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR-VRTRDRTFS 274
           R  A+ LL +   G FLVR+S+ +PG+  +S R     + + I   +  +   + +  F+
Sbjct: 386 RNAAEHLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFN 445

Query: 275 NISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            ++EL+ +H      +            L  P P 
Sbjct: 446 TLAELVHHHSTVADGLI---------TTLHYPAPK 471


>UniRef50_P00519 Tyrosine-protein kinase ABL1 n=113 Tax=root RepID=ABL1_HUMAN
          Length = 1130

 Score =  123 bits (308), Expect = 9e-27,   Method: Composition-based stats.
 Identities = 33/155 (21%), Positives = 59/155 (38%), Gaps = 14/155 (9%)

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
             NT            G+         ++   +    SN   P  +  +    WYHG +S
Sbjct: 76  GDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNS--LEKHSWYHGPVS 133

Query: 218 REDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR-VRTRDRTFS 274
           R  A+ LL +   G FLVR+S+ +PG+  +S R     + + I   +  +   + +  F+
Sbjct: 134 RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFN 193

Query: 275 NISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            ++EL+ +H      +            L  P P 
Sbjct: 194 TLAELVHHHSTVADGLI---------TTLHYPAPK 219


>UniRef50_Q29D50 GA17894 n=4 Tax=Coelomata RepID=Q29D50_DROPS
          Length = 1713

 Score =  122 bits (307), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 12/130 (9%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPG 241
           H  S +     SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG
Sbjct: 237 HSDSGNVGWVPSNYVTPLNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPG 294

Query: 242 KYVLSGRTAENEHKHLILLDNHNR-VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
           +  +S R     + + I  D   +   T++  F+ ++EL+ +H                 
Sbjct: 295 QRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSV-------PHEGHGLI 347

Query: 301 LNLIRPVPCP 310
             L+ P P  
Sbjct: 348 TPLLYPAPKQ 357


>UniRef50_B4MXF9 GK20085 n=1 Tax=Drosophila willistoni RepID=B4MXF9_DROWI
          Length = 1714

 Score =  122 bits (307), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 12/130 (9%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPG 241
           H  S +     SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG
Sbjct: 248 HSDSGNVGWVPSNYVTPLNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPG 305

Query: 242 KYVLSGRTAENEHKHLILLDNHNR-VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
           +  +S R     + + I  D   +   T++  F+ ++EL+ +H                 
Sbjct: 306 QRSISLRYDGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSV-------PHEGHGLI 358

Query: 301 LNLIRPVPCP 310
             L+ P P  
Sbjct: 359 TPLLYPAPKQ 368


>UniRef50_UPI0000E4625F PREDICTED: hypothetical protein n=2 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E4625F
          Length = 520

 Score =  122 bits (307), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 54/286 (18%), Positives = 101/286 (35%), Gaps = 13/286 (4%)

Query: 32  SINVMVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENFPVDINISS-KM 90
           S N   + +   +   C Q       +          +  + +       V+  +     
Sbjct: 236 SRNNGPTALDNPLQRSCKQRPTHNNNIKKPSRKAKRRTPSLYDNPPTKEDVEAKVKQLTP 295

Query: 91  IKIIKQSRLIQRHPFSFFSFGAQGQK---GTDTELMFGYIAKNKDGTD----RRCHVVFI 143
            +  +   +I    +                  +     + K  D         C     
Sbjct: 296 AERNQYQNIIANPDWKKLVDSGYDNLRMLNVWKQSKSVMLHKGGDQEGEYANVACFHDDH 355

Query: 144 EDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVT 203
           +D     +           + + + +   +      P           S +        T
Sbjct: 356 DDDDDDDEHGNRNDGEEEEEEEVDDAQPFNPEAAKQPSNPSAGGGGGASGLHPHDMAPPT 415

Query: 204 EDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
             +  + W+HG +SR++ + LL  +GDFLVR+S     +YVLSG       KHL+L+D  
Sbjct: 416 NPLYNEEWFHGPMSRKEGEPLLSNDGDFLVRESTTAKDQYVLSGM-QNGTPKHLLLVDPQ 474

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            +VRT+D+ F ++S LI+YH NN + + S G    ++++L  PV  
Sbjct: 475 GKVRTKDKEFDSVSHLINYHRNNRLPIISAG----SAVHLKTPVVR 516



 Score = 61.3 bits (147), Expect = 4e-08,   Method: Composition-based stats.
 Identities = 31/165 (18%), Positives = 52/165 (31%), Gaps = 38/165 (23%)

Query: 57  GVTAAREINPVVSRVIGEVKKE---NFPVDINISSKMIKI--IKQSRLIQRHPFSFFSFG 111
           GV      +  + ++IGE          V++ IS+  I I   +  + I  H     SF 
Sbjct: 52  GVCYGVRASKTICKIIGENPNILFGGANVNLTISTASINIRIKETGKPIANHQMQGISFA 111

Query: 112 AQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTS 171
           + G   T                   CHV+  E +  L   + T +    F+ +      
Sbjct: 112 SGGDAVT-------------------CHVL--ECLAGLAQDVITTVG-QAFEIRFKDYLR 149

Query: 172 NDGFTVPAPPMRHRS----SLHRQSFVSNCRAPTVTEDVVGKVWY 212
           N       PP RH+        + S  S+   P          ++
Sbjct: 150 N-------PPQRHQPYTELLGQQGSGGSSPVGPPPGYTANPPPYF 187


>UniRef50_A2RQD6 Bcr-abl1 e6a2 chimeric protein (Fragment) n=6 Tax=Euteleostomi
           RepID=A2RQD6_HUMAN
          Length = 585

 Score =  121 bits (302), Expect = 4e-26,   Method: Composition-based stats.
 Identities = 33/155 (21%), Positives = 59/155 (38%), Gaps = 14/155 (9%)

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
             NT            G+         ++   +    SN   P  +  +    WYHG +S
Sbjct: 415 GDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNS--LEKHSWYHGPVS 472

Query: 218 REDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR-VRTRDRTFS 274
           R  A+ LL +   G FLVR+S+ +PG+  +S R     + + I   +  +   + +  F+
Sbjct: 473 RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFN 532

Query: 275 NISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            ++EL+ +H      +            L  P P 
Sbjct: 533 TLAELVHHHSTVADGLI---------TTLHYPAPK 558


>UniRef50_C1LZD5 Signal transduction protein lnk-related n=1 Tax=Schistosoma mansoni
           RepID=C1LZD5_SCHMA
          Length = 836

 Score =  120 bits (301), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 42/263 (15%), Positives = 77/263 (29%), Gaps = 46/263 (17%)

Query: 73  GEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKD 132
            +    N  ++++ S         +  I  H F   S          +    G+   +  
Sbjct: 495 SDRPITNHSMNLSQSDGCTTTANNT--ISSHGFIKPSNVLYPTPSRPSTFASGFRHTSPS 552

Query: 133 GTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQS 192
                 H +   D    +  LT    +   ++     +  D F   A  + + SS   + 
Sbjct: 553 SHPVSLHSISRPDKSNRLCSLTNNALLEQINSPNTNQSRVDSFRSGAFSVFNSSSNLPRV 612

Query: 193 FVSNCRAPTVTEDVVGKVWYHGNLSREDAQA----------------------------- 223
             S      +   +    WYHG LSR  A +                             
Sbjct: 613 SSSGFED-VIGHQLSIYPWYHGTLSRVRAASYVLGQLSEFEHGTTQQHLTCPESARISFN 671

Query: 224 --------------LLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTR 269
                         L  T+G FLVRQS+   G++VL+           + L      R +
Sbjct: 672 SEQNTTDLSNMPPALSTTDGVFLVRQSETKQGEFVLTFSCHGKPKHLRMTLSPDGHCRVQ 731

Query: 270 DRTFSNISELIDYHVNNGMAVRS 292
              F +I E++++     + +  
Sbjct: 732 HLPFDSIVEMLEHFRQEPIPLEQ 754


>UniRef50_P62993 Growth factor receptor-bound protein 2 n=28 Tax=Chordata
           RepID=GRB2_HUMAN
          Length = 217

 Score =  120 bits (301), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 25/115 (21%), Positives = 53/115 (46%), Gaps = 3/115 (2%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAEN 252
           +   P    ++    W+ G + R  A+ +L   + +G FL+R+S+  PG + LS +   +
Sbjct: 45  DGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGND 104

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                +L D   +       F++++EL+DYH +  ++   +   R+      +P 
Sbjct: 105 VQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPT 159


>UniRef50_UPI00017929BD PREDICTED: similar to proto-oncogene tyrosine-protein kinase abl1
           n=1 Tax=Acyrthosiphon pisum RepID=UPI00017929BD
          Length = 1251

 Score =  120 bits (301), Expect = 7e-26,   Method: Composition-based stats.
 Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 15/130 (11%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPG 241
           H S        SN   P  +  +    WYHG +SR  A+ LL +   G FLVR+S+ +PG
Sbjct: 149 HASPGQVGWVPSNYVTPVNS--LEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPG 206

Query: 242 KYVLSGRTAENEHKHLILLD--NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
           +  +S R     + + I  D  +     T +  F+ ++EL+ +H  +   +         
Sbjct: 207 QRSISLRYEGRVYHYRINEDTSDGKVYVTTESRFNTLAELVHHHSMHSDGLI-------- 258

Query: 300 SLNLIRPVPC 309
              L+ P P 
Sbjct: 259 -TQLLYPAPK 267


>UniRef50_Q17DJ2 Signal transduction protein lnk-realted n=3 Tax=Neoptera
           RepID=Q17DJ2_AEDAE
          Length = 564

 Score =  119 bits (299), Expect = 9e-26,   Method: Composition-based stats.
 Identities = 47/254 (18%), Positives = 89/254 (35%), Gaps = 25/254 (9%)

Query: 74  EVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDG 133
           E+        +   + M  +I+          S+ +      + + T  +      N   
Sbjct: 266 EMPDHENTFVLKADNNMEYVIEARDT--DDMRSWLATIRYCMRSSPTSQLPPITDLNASH 323

Query: 134 TDRRCHVVFIEDVHKLIDVLT------TAINVNTFDAQANASTSNDGFTVPAPPMRHRSS 187
                H             ++       ++  +  +   N S  N   T PAP +  R  
Sbjct: 324 NTSISHGGGPPGGGTTAGSISGGAGLANSLVNDVNNLSLNQSALNAVPTKPAPELPPRRE 383

Query: 188 LHRQSFVSNCRAPT------------VTEDVVGKVWYHGNLSREDAQAL-----LKTEGD 230
             R S  SN                 +T  +    W+HG L+R +A  L     L + G 
Sbjct: 384 EGRISSSSNFELTEGDLEQAHEVDTDLTAMMREYPWFHGTLARSEAAQLVLHNGLSSHGV 443

Query: 231 FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           FLVRQS+   G++VL+           + L++  + R +   F +I+E++++   + + +
Sbjct: 444 FLVRQSETRKGEFVLTFNFQGKAKHLRMTLNDLGQCRVQHLWFPSITEMLEHFRQHPIPL 503

Query: 291 RSEGRDRETSLNLI 304
            S G    T  N +
Sbjct: 504 ESGGTADVTLTNFV 517


>UniRef50_Q21429 Protein K11E4.2, confirmed by transcript evidence n=1
           Tax=Caenorhabditis elegans RepID=Q21429_CAEEL
          Length = 272

 Score =  119 bits (299), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 59/272 (21%), Positives = 108/272 (39%), Gaps = 37/272 (13%)

Query: 9   AEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINPVV 68
           A+ + +SG   +  Y+G  P++++I       R  +V  CI  V ++    A  E + + 
Sbjct: 17  AKHVNASGDRFAVKYMGYAPILQTIRERPIADRDALVRHCINTVVSS---RATHEYSVIQ 73

Query: 69  SRVIGEVKKENFPVD--INISSKMIKI--IKQSR--LIQRHPFSFFSFGAQGQKGTDTEL 122
              +       + +D  +NISS  I    I+  R  L+ R+  +  S      +  D   
Sbjct: 74  HEGVVGPYVSVYQLDLFLNISSFTITCFHIQDGRTHLLGRYKNNQISHYKY--REIDGRH 131

Query: 123 MFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPM 182
             G + K      R C+V  +++   L D+ T                            
Sbjct: 132 YLGIVMKIGRTEKRECNVFMLDNDIALNDLTT--------------------KLRSVDER 171

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGK 242
           RH ++L  ++ + + +    T ++     YHG LS EDA   L   G+F++R S    G+
Sbjct: 172 RHNNALQLETRLRSTQEYRYTPNM--LACYHGPLSHEDACRQLVLPGEFIIRDS-SMRGE 228

Query: 243 YVLSGRTAENEHKHLILLDNHNRVRTRDRTFS 274
           + +S +T+   H   I+ +N+       R F 
Sbjct: 229 FAVSYKTSHGPHDKSIVPNNNIDFF---RRFQ 257


>UniRef50_UPI00017581A1 PREDICTED: similar to GA17645-PA n=3 Tax=Neoptera
           RepID=UPI00017581A1
          Length = 413

 Score =  119 bits (298), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 37/200 (18%), Positives = 72/200 (36%), Gaps = 10/200 (5%)

Query: 119 DTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVP 178
           +   +   +       D+       + +  L    +        +AQ         +   
Sbjct: 218 NVLDIVVALYSFSSTNDQELSFEKGDRLEILDRPPSDPEWYKARNAQGQVGLVPRNYLQE 277

Query: 179 APPMRHRSSLHRQSFVSNCRAPTV--TEDVVGKVWYHGNLSREDAQALLKT---EGDFLV 233
                 +  L R+          +     +V K WY+G+++R     LL     +GDFL+
Sbjct: 278 LSEYLTQPFLDRKQEPMERSQVAMGDKPHLVDKPWYYGSITRYMCDNLLNQRGHDGDFLI 337

Query: 234 RQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           R S+   G Y +S + A   +KH  +           R F  + +L+D++    +    +
Sbjct: 338 RDSETNVGDYSVSLK-APGRNKHFRVHVEGALYCIGQRKFHTLDQLVDHYQRAPIYTNKQ 396

Query: 294 GRDRETSLNLIRPVPCPGSD 313
           G      L L+RP+P P ++
Sbjct: 397 G----EKLYLVRPLPKPTTN 412


>UniRef50_B1AT92 Growth factor receptor bound protein 2 n=7 Tax=Amniota
           RepID=B1AT92_MOUSE
          Length = 203

 Score =  119 bits (297), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 23/97 (23%), Positives = 48/97 (49%), Gaps = 3/97 (3%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLSGRTAEN 252
           +   P    ++    W+ G + R  A+ +L   + +G FL+R+S+  PG + LS +   +
Sbjct: 45  DGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGND 104

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
                +L D   +       F++++EL+DYH +  ++
Sbjct: 105 VQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVS 141


>UniRef50_UPI000180BC22 PREDICTED: similar to protein-tyrosine kinase n=1 Tax=Ciona
           intestinalis RepID=UPI000180BC22
          Length = 445

 Score =  118 bits (296), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 31/139 (22%), Positives = 60/139 (43%), Gaps = 19/139 (13%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPG 241
             +S  +    S      +  D+  + W+HGN+ R +A+ LL+    G FL+R+S+   G
Sbjct: 45  SETSGSKGYLPS----HLIQLDLTNEPWFHGNIGRIEAENLLQYSEPGTFLIRESETIKG 100

Query: 242 KYVLS---GRTAENEHKHLILLDNHNRVRTRD-RTFSNISELIDYHVNNGMAVRSEGRDR 297
            Y L+    +    +  H  +  +  +      R F  + +LI +++ N   +       
Sbjct: 101 SYTLTMIQIKDGTKQISHFRINYDDGKYFITSARRFLGLHQLIQHYMQNSDGL------- 153

Query: 298 ETSLNLIRPVPCPGSDDIE 316
             + NL+ P P P  + +E
Sbjct: 154 --ACNLVYPQPKPSIEYME 170


>UniRef50_Q66I04 Novel protein (Zgc:92124) n=2 Tax=Euteleostomi RepID=Q66I04_DANRE
          Length = 510

 Score =  118 bits (296), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 32/182 (17%), Positives = 67/182 (36%), Gaps = 10/182 (5%)

Query: 142 FIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPT 201
            +E+  K++  L     ++  D                   + RS   R+          
Sbjct: 58  KMEEKEKIVVALYPYEAIHADDLGFKKGEKLKIIEEHGEWWKARSLTTRKEGFIPSNYVA 117

Query: 202 VTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGR----TAENE 253
             + +  + W++ +++R+DA+  L       G +L+R+S+ + G Y LS R      ++ 
Sbjct: 118 EADTMETEEWFYKDITRKDAERQLLAPANKPGSYLIRESETSKGSYSLSIRDVDAQGQDV 177

Query: 254 HKHLILL--DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
            KH  +   DN     +   TFS+IS +I ++      +  +           +P     
Sbjct: 178 VKHYKIRSLDNGGYYISPKITFSDISSMIKHYHKQSDGLCRKLDKACEKPKAQKPWDKDA 237

Query: 312 SD 313
            +
Sbjct: 238 WE 239


>UniRef50_B0WXZ2 Tyrosine-protein kinase shark n=2 Tax=Coelomata RepID=B0WXZ2_CULQU
          Length = 1063

 Score =  118 bits (296), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 38/303 (12%), Positives = 73/303 (24%), Gaps = 56/303 (18%)

Query: 34  NVMVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVI----GEVKKENFPVDINISSK 89
                ++R       +             E+     R I    GE K       ++   K
Sbjct: 104 KPPPHDVRSHGTENLLHRATQANNFPIVSELLKCGYRNIDSKNGEGKTAVHLACLHAEGK 163

Query: 90  MI-KIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMF--------GYIAKNKDGTDRRCHV 140
           ++  +I++   I        +      +  D   M            A+NKD      H 
Sbjct: 164 ILDALIERGCSINNRDAQGNTALHYACRNKDGLEMVRSLIAAGANVQARNKDSGWVPMHE 223

Query: 141 VFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP 200
                 +  ++ +   +                      P    + + H           
Sbjct: 224 AA---ANGNLEAIKELLTHRVPHMPRTGYGEL-------PTDLAKDNGHTAVLDFLNSYE 273

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKTE-------------------------------- 228
                     WYHG L R+ A  +LK                                  
Sbjct: 274 PAQPLTNKSQWYHGTLDRQIAVDILKEHAGKLMPGACSPSKEDKENDSTRSNDNETLDTS 333

Query: 229 GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGM 288
           G +LVR S       VL+          +I    +          +++  LI+++     
Sbjct: 334 GVYLVRYSPKQGVD-VLTLLFDNEARHFIIQRKQNYLYIDDGPYMASLEHLIEHYSRFSD 392

Query: 289 AVR 291
            ++
Sbjct: 393 GLQ 395



 Score = 96.0 bits (237), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 22/114 (19%), Positives = 48/114 (42%), Gaps = 5/114 (4%)

Query: 207 VGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
               W+HG +SRE A+ +L+    +G F+VR+S  + G +VLS    +    + I     
Sbjct: 5   ENLCWFHGKISRERAEEILRQEGGDGVFMVRESASSEGDFVLSVLFQDEMVHYQIRRHGD 64

Query: 264 NRVR--TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDDI 315
           +             +  LI+++  +   + ++ +           V   G++++
Sbjct: 65  DAFFSIDDHTPIHGLESLIEHYRESPNGLVTKLQAICRGKPPPHDVRSHGTENL 118


>UniRef50_B3XVV4 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVV4_9EUKA
          Length = 716

 Score =  118 bits (295), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 32/107 (29%), Positives = 49/107 (45%), Gaps = 5/107 (4%)

Query: 187 SLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKY 243
                   SN       + + G+ W+ G +SR +A A+L+    EG FLVR+S+  PG+Y
Sbjct: 323 HGEVGFVPSNYL--CRIQGLEGEPWFRGRISRAEAAAMLQITKQEGCFLVRESETQPGEY 380

Query: 244 VLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
            LS    E    + I           +  F +I +LI+YH  NG  +
Sbjct: 381 TLSLSHNEGVRHYRIQHIEGQYFVNENHRFDSIPQLIEYHKLNGGGI 427


>UniRef50_C4QLR4 Shc transforming protein, putative (Fragment) n=1 Tax=Schistosoma
           mansoni RepID=C4QLR4_SCHMA
          Length = 409

 Score =  117 bits (293), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 65/278 (23%), Positives = 110/278 (39%), Gaps = 27/278 (9%)

Query: 37  VSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQ 96
             + R+  V EC   +A  V +T  +         I         ++++ ++      + 
Sbjct: 146 DQDTRMCYVFECSDGLAQDVIITIGQAFQLGYQVNINTNSHLQIVMEVSANTATSLSKEN 205

Query: 97  SRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKN-KDGTDRRCHVVFIEDVHKLIDVLTT 155
           + L Q       +   Q     +     G++                            +
Sbjct: 206 TALSQNTSMPNNNVTHQPVAFDN---FMGHLGNEISSDNQTDSAEYNKPSCGTKKSSAQS 262

Query: 156 AINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVG-----KV 210
             N  T +                 P R  + +     +SN +AP    +        + 
Sbjct: 263 NQNELTQELSQQ-------------PSRKINKVAGVKSISNIKAPVGLPNFEHLEPVGEP 309

Query: 211 WYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD 270
           WY G +SR  A+ LL+ +GDFLVR S   PG++VLSG   + +++HL+L D + +VRT++
Sbjct: 310 WYVGKMSRSQAENLLRYDGDFLVRASIQQPGQFVLSGL-QDGKYRHLLLADPNGKVRTKE 368

Query: 271 RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
           R F +I  LIDYHV NG  +RS     ++ + LI PV 
Sbjct: 369 RVFDSIQHLIDYHVQNGAPIRS----LDSEIRLIFPVS 402



 Score =  111 bits (278), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 37/160 (23%), Positives = 66/160 (41%), Gaps = 12/160 (7%)

Query: 7   SFAEELRSSGVSLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAA--REI 64
             ++    +GV+    Y+G++PV+ SI  +   +R ++    I+ V   VG+     R  
Sbjct: 17  HDSQLAADAGVTFELQYVGAIPVLTSIKSVNINIRTRICRASIRRVCEDVGLKLPSNRSA 76

Query: 65  NPVVSRVIG---EVKKENFPVDINISSKMIK--IIKQSRLIQRHPFSFFSFGAQGQKGTD 119
           +  + + IG   ++      V + I+S+ +    I    L+ +H     SF + G    D
Sbjct: 77  DKSIEQFIGPSTDMTWAIVNVYLTITSQTLTVETIDNGVLLFQHNLFLVSFASAGD--AD 134

Query: 120 TELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINV 159
           T     Y+AK    T R C+V   E    L   +   I  
Sbjct: 135 TPDFICYVAKTDQDT-RMCYVF--ECSDGLAQDVIITIGQ 171


>UniRef50_UPI0000E49CFC PREDICTED: similar to Ras GTPase-activating protein 1
           (GTPase-activating protein) (GAP) (Ras p21 protein
           activator) (p120GAP) (RasGAP) n=3 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000E49CFC
          Length = 628

 Score =  117 bits (293), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 38/161 (23%), Positives = 60/161 (37%), Gaps = 18/161 (11%)

Query: 153 LTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWY 212
           +   +   + D Q +    +        P    + L  ++  +N  AP          WY
Sbjct: 16  VRERLLGTSADMQNSDEFQDLPVHDDFDPFESYTELPEETVDANLTAPP------ENEWY 69

Query: 213 HGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTR 269
           HG L R+ A+  L      G +LVR+S+  PG YVLS    +    H  +          
Sbjct: 70  HGCLDRQSAELRLNAADKPGSYLVRESERKPGSYVLSYL-GQRGINHFRVTAVCGDFYVG 128

Query: 270 DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
            R F  + ELI Y+ +    +++E         L  P P P
Sbjct: 129 GRQFQTLPELIGYYTHISNILKNE--------RLQYPAPPP 161



 Score = 87.5 bits (215), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 32/132 (24%), Positives = 54/132 (40%), Gaps = 6/132 (4%)

Query: 179 APPMRHRSSLHRQSFVSNCRAPTVTE--DVVGKVWYHGNLSREDAQALLKTEGD---FLV 233
              +  + S      V +   P   E     GKVW+HGN+S+E+A   L  +GD   FL+
Sbjct: 203 WLWVTSQRSGESGIIVQDLVKPVEGEIDPNEGKVWFHGNVSKEEAAETLWKDGDIGGFLI 262

Query: 234 RQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           R SD  PG Y LS R      +   +     +     R ++++  ++D++    +    +
Sbjct: 263 RNSDKNPGDYSLSFRGPNTIQR-FRIQKQQRQYVMGGRYYNSLDAIVDHYKKEEIIDGFK 321

Query: 294 GRDRETSLNLIR 305
            RD         
Sbjct: 322 LRDPTAPKKFKN 333


>UniRef50_Q13588 GRB2-related adapter protein n=31 Tax=Coelomata RepID=GRAP_HUMAN
          Length = 217

 Score =  117 bits (292), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 26/114 (22%), Positives = 53/114 (46%), Gaps = 3/114 (2%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLSGRTAEN 252
               P     V    WY G +SR+ A+ +L      G FL+R+S+ +PG++ +S    + 
Sbjct: 45  EGFIPKNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQ 104

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
                +L +   +    +  F++++EL+D++    +A + +   R+    L  P
Sbjct: 105 VQHFKVLREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSP 158


>UniRef50_A9V014 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V014_MONBE
          Length = 575

 Score =  117 bits (292), Expect = 7e-25,   Method: Composition-based stats.
 Identities = 27/125 (21%), Positives = 44/125 (35%), Gaps = 3/125 (2%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSD 237
               ++   ++     C    +   +    W HG +SR  A  LLK    +G +LVR+S 
Sbjct: 44  WWNAQNLNTKKKGWIPCSLVALDGSLELFDWCHGAISRNGADYLLKQHGIDGMYLVRESQ 103

Query: 238 HTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
             PG+Y L          + I   +      +   F  I ELI +H      + S     
Sbjct: 104 SQPGQYTLDVWKEGKSVHYRITKGDEGYFFRQGVCFPTIPELIQHHQTRSDGLCSSLDHI 163

Query: 298 ETSLN 302
               +
Sbjct: 164 APKAH 168


>UniRef50_Q29PM3 GA21540 n=6 Tax=Drosophila RepID=Q29PM3_DROPS
          Length = 965

 Score =  116 bits (291), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 51/299 (17%), Positives = 105/299 (35%), Gaps = 22/299 (7%)

Query: 22  TYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENFP 81
            Y G++    ++     E  V +  + ++      G+ +A     +++ ++G   K    
Sbjct: 59  QYEGNLQAYSTV-----EDVVDITDKELKRC----GIRSAHR-QMMINSLLGVRAKRRQS 108

Query: 82  VDINISSKMIKII--KQSRLIQRHPFSFFSFGAQGQKGTDTE-LMFGYIAKNKDGTDRRC 138
           +++  +S    ++  K S  +     S       G  G        G + K     D   
Sbjct: 109 MNLEANSAPRPVLRRKNSCPLVYLEESSIDISGSGDSGRGLIITKSGKVLKQLTFDDTNT 168

Query: 139 HVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCR 198
               +    K       A N+++     + S ++    V +P    +             
Sbjct: 169 IYEELRPRSKCNSPHWAAANIDSEMEHNSGSNASTPIAVNSPNPNEQQEAIALKKALEWE 228

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
                 ++    WYHG L R+ A+ +++ EGDFLVR     P  YVLS R+       ++
Sbjct: 229 LSLDARELRSHAWYHGPLPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKLAVLHFVL 288

Query: 259 LL--------DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE-GRDRETSLNLIRPVP 308
                         + +  +  F  + +LI ++V +G  + +  G   +   N   P+ 
Sbjct: 289 NKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISAASGALIQYPCNRRYPLS 347


>UniRef50_UPI00019245DF PREDICTED: similar to Cytoplasmic protein NCK2 n=1 Tax=Hydra
           magnipapillata RepID=UPI00019245DF
          Length = 384

 Score =  116 bits (291), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 39/140 (27%), Positives = 63/140 (45%), Gaps = 8/140 (5%)

Query: 173 DGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEG 229
                P P     S     +     +  T       K WYHG LSR + + LL     +G
Sbjct: 242 SPVLTPGPTKPKHSISSLNTNPPIVKDETPDCIFRDKDWYHGTLSRSECEFLLNEHAKDG 301

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
           ++L+R S+  PG + LS + A N  KH  +L  +N+     R+FSNI EL+ ++ N  + 
Sbjct: 302 EYLIRNSESKPGDFSLSMK-APNRIKHFKILYGNNQYVIGQRSFSNIDELLSHYKNYPIY 360

Query: 290 VRSEGRDRETSLNLIRPVPC 309
               G+     ++L+ P+  
Sbjct: 361 TTENGQ----KMHLLYPLNK 376


>UniRef50_UPI000179134F PREDICTED: similar to signal transduction protein lnk-realted,
           partial n=1 Tax=Acyrthosiphon pisum RepID=UPI000179134F
          Length = 474

 Score =  116 bits (290), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 38/211 (18%), Positives = 86/211 (40%), Gaps = 15/211 (7%)

Query: 116 KGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGF 175
              + E +   ++  +           +     L D ++      + D   ++S ++   
Sbjct: 207 DENNVEYIIDALSPEEMRQWLATVKYCMRKRDGLHDDISIIG---SIDGVLDSSVAHSND 263

Query: 176 TVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT-----EGD 230
           T+ + P    S+ +  + ++N     ++  +    W+HG L+R DA  L+        G 
Sbjct: 264 TLLSSP--QSSTNNLDTILNNDVENDISASLRLYPWFHGMLARSDATNLVSHLGTNGHGM 321

Query: 231 FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           FLVRQS+   G+YVL+           + L++    R +  +F +I +++++   + + +
Sbjct: 322 FLVRQSETRKGEYVLTFNFKGKPKHLRMTLNDQGHCRVQHLSFPSIQDMLEHFQTHLIPL 381

Query: 291 RSEGRDRET--SLNLIRPVP---CPGSDDIE 316
            + G    T     L  P+     P + +I+
Sbjct: 382 ENGGPGDVTLRDYILNTPIKYGVFPSNTNID 412


>UniRef50_Q4RUN4 Chromosome 12 SCAF14993, whole genome shotgun sequence n=2
           Tax=Chordata RepID=Q4RUN4_TETNG
          Length = 1136

 Score =  116 bits (290), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 49/242 (20%), Positives = 76/242 (31%), Gaps = 19/242 (7%)

Query: 73  GEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKD 132
              +  N   D ++    I        I     +  S G+ G  G  T            
Sbjct: 53  AVRQHSNTSPD-SLPDMSITYPLSGGDIS--GAAVSSTGSGGAVGGHTLFQGTSSGTGSG 109

Query: 133 GTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSS-LHRQ 191
                      E     I   +T  +  T              TV    M+  +     +
Sbjct: 110 TCC----SPTSEGPASRISPTSTGPDGPTVFPPLPPPPPPPPGTVDESDMQDGTECDEEE 165

Query: 192 SFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGR 248
                   P+         WYHG L R  A+  L+     G +L+R+SD  PG +VLS  
Sbjct: 166 VAFPLSAPPSNHSPPRMPRWYHGKLDRTIAEERLRQARNPGSYLIRESDRRPGSFVLSFL 225

Query: 249 TAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
           +  N   H  ++          R FS++S+LI Y+      ++ E         L+ PV 
Sbjct: 226 SMTNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSYVSCLLKGE--------KLLSPVA 277

Query: 309 CP 310
            P
Sbjct: 278 PP 279



 Score = 76.7 bits (187), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 34/148 (22%), Positives = 56/148 (37%), Gaps = 45/148 (30%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
             +   GKVWYHG++++++A  LL T G    FLVR SD+TPG Y L  RT +   +  I
Sbjct: 350 EEDPHEGKVWYHGHITKKEAYNLLMTVGQVCSFLVRPSDNTPGDYSLFFRTNDIIQRFKI 409

Query: 259 LLDNHNRVRTRDRTF---------------------------------SNISELIDYHVN 285
              ++N+     R +                                  ++ ++ID++  
Sbjct: 410 SPTSNNQYMMGGRYYNRYEPICMLGHHFQSSGYHVFSFFLRFNCAASVDSVDDIIDHYKK 469

Query: 286 NGMAVRSEGRDRETSLNLIRPVPCPGSD 313
             +             NL  PV     +
Sbjct: 470 EQIV---------EGYNLKEPVSVQQQE 488


>UniRef50_Q9VMJ4 CG9098, isoform A n=8 Tax=melanogaster group RepID=Q9VMJ4_DROME
          Length = 944

 Score =  116 bits (289), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 31/150 (20%), Positives = 55/150 (36%), Gaps = 9/150 (6%)

Query: 168 ASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT 227
           +S +        P    +                   ++    WYHG L R+ A+ +++ 
Sbjct: 197 SSNATTPLATAQPSPSEQQEAIALKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQR 256

Query: 228 EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL--------DNHNRVRTRDRTFSNISEL 279
           EGDFLVR     P  YVLS R+       ++              + +  +  F  + +L
Sbjct: 257 EGDFLVRDCASQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEEDAFDTVPDL 316

Query: 280 IDYHVNNGMAVRSE-GRDRETSLNLIRPVP 308
           I ++V +G  + S  G   +   N   P+ 
Sbjct: 317 ITFYVGSGKPISSASGALIQFPCNRTYPLS 346


>UniRef50_UPI0000612FE6 UPI0000612FE6 related cluster n=1 Tax=Bos taurus
           RepID=UPI0000612FE6
          Length = 689

 Score =  116 bits (289), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 46/326 (14%), Positives = 98/326 (30%), Gaps = 74/326 (22%)

Query: 58  VTAAREINPVVSRVIG-----------EVKKENFPVDINISSKMIKIIKQSRLIQRH--- 103
               +   P VS  +            E+ +++    + + +    I++    +Q+H   
Sbjct: 241 FVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWV 300

Query: 104 ----------------PFSFFSFGAQGQKGTDT-ELMFGYIAKNKDGTDRRCHVVFIEDV 146
                           P    +  A G +           I           H + +  V
Sbjct: 301 ADIQGCVDPGLCRFRVPRPGAAPLANGVRRHPPHIPEVVLIPPLPPSQPSAPHTLCLTPV 360

Query: 147 HKLIDVLTTAINVNTFDAQA------------------------------------NAST 170
            K++    T         +                                     +  +
Sbjct: 361 KKILTERGTKGQNQGDGDKDTLSFSPLCASVYLIHLFSVIQRASYLQKPNKLIKMTHPCS 420

Query: 171 SNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----- 225
           ++ G +VP P     S+    +            ++    W+HG LSR  A  L+     
Sbjct: 421 ASCGPSVPTPLTLPSSAAEEAAEPEAQAE--AELELSDYPWFHGTLSRVKAAQLVLAGGP 478

Query: 226 KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVN 285
           +  G F++RQS+  PG+YVL+           + L+ H +   +   F ++ +++ +   
Sbjct: 479 RNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHT 538

Query: 286 NGMAVRSEGRDRETSLNLIRPVPCPG 311
           + + + S G    T  + +R    P 
Sbjct: 539 HPIPLESGGSADITLRSYVRAQGPPP 564


>UniRef50_Q4SII9 Chromosome 5 SCAF14581, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SII9_TETNG
          Length = 921

 Score =  116 bits (289), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 34/112 (30%), Positives = 51/112 (45%), Gaps = 7/112 (6%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
            V   +  + WYHG + R + Q LL  +GDFLVR+S   PG YVLS   +    KH ++ 
Sbjct: 518 EVERPLEQQTWYHGAIPRLEVQQLLTKDGDFLVRKSQEKPG-YVLSVHWSGAC-KHFLVQ 575

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGS 312
           +  N       +F  I +LI  +  +   V       ++ + L RPV     
Sbjct: 576 NKDNMYCLDGESFHTIPQLIQQYQTSQQHVTK-----KSEVVLRRPVLKDKW 622


>UniRef50_UPI0001757DDC PREDICTED: similar to MGC80357 protein n=1 Tax=Tribolium castaneum
           RepID=UPI0001757DDC
          Length = 952

 Score =  115 bits (288), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 40/201 (19%), Positives = 73/201 (36%), Gaps = 15/201 (7%)

Query: 112 AQGQKGTDTELMFGYIAKNKDG-TDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANAST 170
           ++G     T L+            +R   VV+    H  I  +              AS 
Sbjct: 454 SRGNHSPPTVLIQALCHIFLRPPWERIIQVVYNTQSHNRILEVLLLKCSWGVKLPEFASA 513

Query: 171 SNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--TE 228
                    PP R   +    +  +  +  +    +    WY G++ RE+    LK   +
Sbjct: 514 PAI------PPRRAVGTARISTNSTLDKEKSNAFSLQEAEWYWGDIKREEVNEKLKETPD 567

Query: 229 GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV-RTRDRTFSNISELIDYHVNNG 287
           G FLVR +    G+Y L+ R     +K + +   + +   T   TF+++ ELI++  N  
Sbjct: 568 GTFLVRDASTKSGEYTLTLR-KGGTNKLIKICHKNGKYGFTEPYTFNSVVELINHFRNES 626

Query: 288 MAVRSEGRDRETSLNLIRPVP 308
           +       +    + L+ PV 
Sbjct: 627 L----SQYNASLDIKLLYPVS 643



 Score = 65.9 bits (159), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 24/133 (18%), Positives = 46/133 (34%), Gaps = 16/133 (12%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKV--WYHGNLSREDAQALL--KTEGDFLVRQSDHT 239
           +R+S   +    +     V   +      W   +  R DA+  L  + +G FL+R S  +
Sbjct: 806 NRNSEDEEYNTQSGEECDVDSLIHNDERTWLMLDCRRIDAEKYLAGQPDGTFLIRTSSTS 865

Query: 240 PGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT-----FSNISELIDYHVNNGMAVRSEG 294
              Y LS         H I+ D                +  + +L+ ++  N +    E 
Sbjct: 866 K--YALSIACN-KMVNHCIIHDTKRGXXXXXXXXPYNIYPTLKDLVLHYATNSL----EI 918

Query: 295 RDRETSLNLIRPV 307
            +   +  L  P+
Sbjct: 919 HNDSLNTVLAHPL 931


>UniRef50_O76978 Tyrosine kinase n=1 Tax=Sycon raphanus RepID=O76978_9METZ
          Length = 879

 Score =  115 bits (288), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 38/113 (33%), Positives = 52/113 (46%), Gaps = 8/113 (7%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
            P     V  + WYHG +SR++A  LLK  GDFLVR S      Y L+ +      KH I
Sbjct: 505 TPEAHAGVEEEPWYHGEISRQEATGLLKKMGDFLVRYSADKE-HYTLTVKMEG--IKHFI 561

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
           +  N    R     + +I  LID+H  N + V      R++   L +PV  P 
Sbjct: 562 IQHNEEGFRFEGDPYPSIPMLIDHHFKNRLPVT-----RKSQAILRQPVKKPD 609


>UniRef50_A8QDY0 Protein kinase domain containing protein n=1 Tax=Brugia malayi
           RepID=A8QDY0_BRUMA
          Length = 384

 Score =  115 bits (287), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 31/115 (26%), Positives = 51/115 (44%), Gaps = 9/115 (7%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAENEHKHLI 258
               +    WYHG L R+D   LL  +G FLVR+++   G   + VLS +  +    H I
Sbjct: 4   KEPGLEFAEWYHGLLPRKDINILLSKQGQFLVRETEIKKGEGLQLVLSVKWNDKTM-HFI 62

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           +     +V    R F++I  LI YH+ +   +       ++   L+  VP    +
Sbjct: 63  IRHVDGKVFIEKRQFNSIHALIRYHLVSKDPIT-----DQSGAMLLHAVPRQSWE 112


>UniRef50_P29349 Tyrosine-protein phosphatase corkscrew n=19 Tax=Diptera
           RepID=CSW_DROME
          Length = 845

 Score =  114 bits (286), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 35/128 (27%), Positives = 58/128 (45%), Gaps = 8/128 (6%)

Query: 182 MRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDH 238
           M +     +       + P +  +   + W+HGNLS ++A+ L+      G FLVR+S  
Sbjct: 82  MENGELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILERGKNGSFLVRESQS 141

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
            PG +VLS RT +     +I   +         +F  +SELID++  N M          
Sbjct: 142 KPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMV-----ETCG 196

Query: 299 TSLNLIRP 306
           T ++L +P
Sbjct: 197 TVVHLRQP 204



 Score =  103 bits (257), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 31/116 (26%), Positives = 55/116 (47%), Gaps = 11/116 (9%)

Query: 206 VVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +  + W+H  +S  +A+ LL+    +G FL R S   PG + LS R   NE  H+ + +N
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVR-RGNEVTHIKIQNN 59

Query: 263 HNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC--PGSDDI 315
            +         F+ + EL+ Y++ NG      G+     + L +P+ C  P ++  
Sbjct: 60  GDFFDLYGGEKFATLPELVQYYMENGELKEKNGQA----IELKQPLICAEPTTERW 111


>UniRef50_Q08012 Protein enhancer of sevenless 2B n=35 Tax=Eumetazoa RepID=DRK_DROME
          Length = 211

 Score =  114 bits (286), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 31/154 (20%), Positives = 60/154 (38%), Gaps = 8/154 (5%)

Query: 147 HKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDV 206
             +     +A   +    +             +   R           SN          
Sbjct: 2   EAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKN---- 57

Query: 207 VGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
               WY+G ++R DA+ LL  K EG FL+R S+ +PG + LS +  +      +L D  +
Sbjct: 58  --HDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQS 115

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
           +       F++++EL++YH    ++   + + R+
Sbjct: 116 KFFLWVVKFNSLNELVEYHRTASVSRSQDVKLRD 149


>UniRef50_B7PEL7 Signal transduction protein lnk-realted, putative n=1 Tax=Ixodes
           scapularis RepID=B7PEL7_IXOSC
          Length = 553

 Score =  114 bits (285), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 45/263 (17%), Positives = 83/263 (31%), Gaps = 24/263 (9%)

Query: 74  EVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDG 133
           E+        +  S   + +++          S+ S      +            +    
Sbjct: 249 EMPDHENTFVLKASPPSLYVVEAHD--AESMKSWLSTIRYCMRHLGDTSEDNVRPRQGCF 306

Query: 134 T---DRRCHVVFIEDV--------------HKLIDVLTTAINVNTFDAQANASTSNDGFT 176
               DRRC   F+ D                       +  +     A A +  +  G  
Sbjct: 307 NEVVDRRCLPCFLSDKLMKAAAESATAVGEPAAAGTPRSGADSVAAIAPAASPVAASGAA 366

Query: 177 VPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG-----DF 231
                    ++              + + +    W+HG LSR DA  L+  EG      F
Sbjct: 367 TADSGASPPTTGGVPCEPEAREGGDLYQSLREYPWFHGTLSRSDAAQLVLREGPLGHGVF 426

Query: 232 LVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
           LVRQS+   G+ VL+           + L+   + R +   F  I +++++   + + + 
Sbjct: 427 LVRQSETRKGECVLTFNFQGRAKHLRMTLNPEEQCRVQHLWFQTIFDMLEHFRVHPIPLE 486

Query: 292 SEGRDRETSLNLIRPVPCPGSDD 314
           S G    T  + +   P PGS D
Sbjct: 487 SGGASDVTLTDFVLATPSPGSGD 509


>UniRef50_UPI0001793830 PREDICTED: similar to protein tyrosine kinase n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793830
          Length = 686

 Score =  114 bits (285), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 43/301 (14%), Positives = 89/301 (29%), Gaps = 25/301 (8%)

Query: 36  MVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVIGEVKKENFPVDINISSKM----- 90
              + R    +  +             E+     R + E K +     ++++S+M     
Sbjct: 112 PPHDTRRHGRTNLLHRAITQANCKVVTELLKCGYRNL-EAKNQEGQTALHLASQMGHDQI 170

Query: 91  -IKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKL 149
             K+I     +       ++      +      +   +         R        +H+ 
Sbjct: 171 VEKLISCGANVNCRDTEGYTPLHFACQNNLLNTVKILLTVGGANIQLRNSSTGWVALHEA 230

Query: 150 IDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGK 209
                  I        A +        +PA   R       +  ++   +P  +      
Sbjct: 231 SSRGHADIVTLLLSMNAPSRPRTFDDLLPADLARTNGHTEVEQMLNEFVSPMPSS--RKD 288

Query: 210 VWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
            WYHG L R +A A+LKT   +G FLVR   +    YVLS       +   I   +    
Sbjct: 289 QWYHGKLDRHEATAILKTKDVDGCFLVR--MNRQSGYVLSMMCTNQCYHFQIQDRDKYYF 346

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLN-----------LIRPVPCPGSDDI 315
                  +++  LI ++      + ++     +              L +P P   ++  
Sbjct: 347 IDNGPYLNSLEHLIQHYTLFPDGLPNKLEVPVSPAVIPPLPKGFPFTLKKPKPKHQTEFQ 406

Query: 316 E 316
           +
Sbjct: 407 D 407



 Score = 91.0 bits (224), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 26/114 (22%), Positives = 42/114 (36%), Gaps = 18/114 (15%)

Query: 208 GKVWYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
              WYHG +SR+ A+ +L     K +G FLVR+S+   G YVL          + I    
Sbjct: 9   DINWYHGKISRDTAEIILLDHESKEDGLFLVRESNSASGDYVLCVLQNNEVVHYQIRRHG 68

Query: 263 HNRVR--TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV---PCPG 311
            +             +  LI+++                 + L +P+   P P 
Sbjct: 69  EDAFFSIDEQNIMHGLETLIEHYCKVNDP--------SLGVQLSKPIVKDPPPH 114


>UniRef50_A8WHR4 Novel protein similar to H.sapiens SHD, Src homology 2 domain
           containing transforming protein D (SHD) n=1 Tax=Danio
           rerio RepID=A8WHR4_DANRE
          Length = 321

 Score =  114 bits (285), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 37/202 (18%), Positives = 74/202 (36%), Gaps = 16/202 (7%)

Query: 116 KGTDTELMFGYIAKNKDGTDRRCHVVFIE------DVHKLIDVLTTAINVNTFDAQANAS 169
           +   ++               +  V          +  + I+V   A + +      + +
Sbjct: 121 ETDYSDPFDARPDPRPRPGWEQNAVEACSSYMEPFEAQRFINVTFEAADWDQCTLPCDEA 180

Query: 170 TSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--T 227
               G +  +PP    ++  R+              +  +VWYHG L+R +A++LL    
Sbjct: 181 LRKAGVSRVSPPS-SGATSLRKPHGILGERVDPMLPLEKQVWYHGALTRSEAESLLTLCK 239

Query: 228 EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--FSNISELIDYHVN 285
           E  +LVR+S  +   Y LS R+               +    + +  F +I E+I ++  
Sbjct: 240 ECSYLVRKSQTSRNDYSLSLRSCHGFMHMKFSQSRDGKFILGENSPPFDSIPEVIHFYTT 299

Query: 286 NGMAVRSEGRDRETSLNLIRPV 307
           N + +R         L+L+ PV
Sbjct: 300 NKLPIRGA-----EHLSLLFPV 316


>UniRef50_Q7QGU0 AGAP010886-PA (Fragment) n=1 Tax=Anopheles gambiae
           RepID=Q7QGU0_ANOGA
          Length = 837

 Score =  114 bits (284), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 36/151 (23%), Positives = 61/151 (40%), Gaps = 14/151 (9%)

Query: 166 ANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP----TVTEDVVGKVWYHGNLSREDA 221
              S + +       P +   +L     +   R        +  +  + WYHG++SR DA
Sbjct: 687 FKQSLTLNLNECGQRPPKKFGTLDLGLNLGTNRPNVDLIDASIPLDRQGWYHGSISRIDA 746

Query: 222 QALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH-NRVRTRD--RTFSNI 276
           + +L+   EG FLVR S+ T   Y L+ ++A+      I  D    +       R F  I
Sbjct: 747 EKILRPLSEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDADSGQFILGQFSRPFPTI 806

Query: 277 SELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
            ++I +   N + VR         + L+ PV
Sbjct: 807 PDMIRHFCLNRLPVRGA-----EHMCLLEPV 832


>UniRef50_UPI000058445F PREDICTED: similar to SH2/SH3 adaptor protein n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI000058445F
          Length = 389

 Score =  114 bits (284), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 36/197 (18%), Positives = 75/197 (38%), Gaps = 21/197 (10%)

Query: 115 QKGTDTELMFGYIAKNKDG--TDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSN 172
           +   D   +   I+   D     +         +  +  V +  + V         +   
Sbjct: 205 ELNFDASELLDIISNPSDDQDWWKA-----RNKLGTVGLVPSNYVKVVENADPVCPTKFF 259

Query: 173 DGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD-- 230
               VP  P+             N   P+ +     + W+HG ++R+D++ +L   G+  
Sbjct: 260 IEDAVPPKPIEMHDE-------DNSFTPSSSVGFYDRDWFHGRITRQDSEKILGCPGESG 312

Query: 231 -FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMA 289
            FL+R+S+  PG + +S +  E   KH  +  +  +     R F ++ +L+D++  + + 
Sbjct: 313 LFLIRESETMPGDFAVSVKAPERV-KHFKVTRSDKKFCIGQRKFESLDDLVDHYKRSPIF 371

Query: 290 VRSEGRDRETSLNLIRP 306
              +G      L L RP
Sbjct: 372 SSDDGE---LKLYLTRP 385


>UniRef50_Q7PSB5 AGAP009560-PA (Fragment) n=3 Tax=Culicidae RepID=Q7PSB5_ANOGA
          Length = 940

 Score =  114 bits (284), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 33/178 (18%), Positives = 64/178 (35%), Gaps = 11/178 (6%)

Query: 140 VVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRA 199
                        +    N  T +       +        P   + +   +++       
Sbjct: 171 QFRSVCHGGWGQSVVCTDNKMTNNIGVVFGGAKCSLQETTPDGGNEAVALKKALEWEL-- 228

Query: 200 PTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
              + D+    WYHG + R+ A+ +++ EGDFLVR     PG YVL+ RT       +I 
Sbjct: 229 SLDSRDLRSHAWYHGPIPRQRAEEIVQKEGDFLVRDCVSQPGNYVLTCRTKGPTLHFVIN 288

Query: 260 L--------DNHNRVRTRDRTFSNISELIDYHVNNGMAVR-SEGRDRETSLNLIRPVP 308
                        + +  D  +  + +LI ++V +G ++  + G   +   N   P+ 
Sbjct: 289 KLLLQPETVYERVQYQFEDDAYDTVPDLITFYVGSGKSISVASGARIQFPCNRTYPLS 346


>UniRef50_B3XVV9 Protein tyrosine kinase n=1 Tax=Monosiga ovata RepID=B3XVV9_9EUKA
          Length = 630

 Score =  114 bits (284), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 27/147 (18%), Positives = 56/147 (38%), Gaps = 18/147 (12%)

Query: 172 NDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK----T 227
           N   +     + +  +  +    ++  A   +  +    W+ G ++R  A+  L      
Sbjct: 200 NKDPSKEWTLVENCVTGCQGFVPTSFIA--ASASLESHAWFFGKIARSKAEKFLNDPRCH 257

Query: 228 EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD---RTFSNISELIDYHV 284
            G FL+R+S+ +PG+Y LS R  +    + +        + +    + F+++ ELI +H 
Sbjct: 258 HGSFLIRESESSPGQYSLSLRDGDTVRHYRVENYEGGLYKLQGSPTQKFASLPELIAFH- 316

Query: 285 NNGMAVRSEGRDRETSLNLIRPVPCPG 311
                     R    +  L  P P   
Sbjct: 317 --------GQRKAGLATALREPCPKES 335


>UniRef50_Q0PDJ5 Protein tyrosine kinase CSK n=3 Tax=Codonosigidae
           RepID=Q0PDJ5_9EUKA
          Length = 468

 Score =  114 bits (284), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 29/113 (25%), Positives = 51/113 (45%), Gaps = 11/113 (9%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
             +  ++   W+HG +SRE A++LL  + +G FLVR+S H PG Y L     +    + +
Sbjct: 91  DASGQLIPMPWFHGKISRELAESLLMPREDGLFLVRESAHFPGDYTLCVCFQDQVDHYRM 150

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
              N       +  FS++ EL+ ++  +   +            L +PV   G
Sbjct: 151 QGKNGKLTIDEEVYFSSLEELVQHYEKDADGLC---------TRLRKPVVKQG 194


>UniRef50_A2RUZ0 Zgc:158474 protein n=2 Tax=Euteleostomi RepID=A2RUZ0_DANRE
          Length = 906

 Score =  113 bits (283), Expect = 7e-24,   Method: Composition-based stats.
 Identities = 42/243 (17%), Positives = 87/243 (35%), Gaps = 12/243 (4%)

Query: 74  EVKKENFPVDINISSKMIKIIKQSRLIQRHP-FSFFSFGAQGQKGTDT----ELMFGYIA 128
           EV  +     + +  ++  +I+    +Q     S         +  D           ++
Sbjct: 571 EVPDKENTFLLQMEGQVQYVIETRDAVQMRAWLSDIRNAICLSEQEDVDGVCGSALTDLS 630

Query: 129 KNKDGTDRRCHVVF--IEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRS 186
              + +DR   V +  +    +L  +          D   +      G ++  P      
Sbjct: 631 GTPEFSDRLSQVCYGGVGGSPQLEPLPPELPPRAPLDESDSRLLGGGGASLGTPFAETPD 690

Query: 187 SLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK-----TEGDFLVRQSDHTPG 241
           +     F     + TV   +    W+HG LSR  A  L+      + G FLVRQS+   G
Sbjct: 691 ATGSFLFSDVSVSETVEHPLSECQWFHGTLSRLKAAQLVLAGGMASHGVFLVRQSETRRG 750

Query: 242 KYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSL 301
           +YVL+           + L+   + R +   F +I +++++   + + + S G    T +
Sbjct: 751 EYVLTFNFQGKAKHLRLSLNEDGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGASDVTLI 810

Query: 302 NLI 304
           + +
Sbjct: 811 SFV 813


>UniRef50_A9UQ58 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQ58_MONBE
          Length = 635

 Score =  113 bits (283), Expect = 7e-24,   Method: Composition-based stats.
 Identities = 39/189 (20%), Positives = 65/189 (34%), Gaps = 18/189 (9%)

Query: 128 AKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANAS---TSNDGFTVPAPPMRH 184
           ++ +  + R         V  +   +         +         T           MR 
Sbjct: 44  SRQRQPSHRADRYPREPQVGDVFVGVYNFQGRTEPELSFERGEKLTLLRRLDENWWLMRS 103

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGK 242
           + S       SN  AP   +D+    WYH N+SR  A+ LLK+  +G FLVR+S  +PG+
Sbjct: 104 QRSGKEGYAPSNYIAP--FKDINRNPWYHSNISRNTAEYLLKSGVDGSFLVRESLSSPGE 161

Query: 243 YVLSGRTAEN-EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSL 301
           Y ++ R        + I  D         + F+ + +L+ +H                  
Sbjct: 162 YSITLRCDGKARTHYRINHDARGYFVAAGKFFATVEQLVAHH---------AVVADGLVA 212

Query: 302 NLI-RPVPC 309
            L   PV  
Sbjct: 213 CLKQHPVEK 221


>UniRef50_UPI0000ECA6D9 SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Gallus gallus RepID=UPI0000ECA6D9
          Length = 506

 Score =  113 bits (283), Expect = 7e-24,   Method: Composition-based stats.
 Identities = 42/293 (14%), Positives = 78/293 (26%), Gaps = 30/293 (10%)

Query: 35  VMVSEMRVQVVSECIQHVAATVG-------VTAAREINPVVSRVIGEVKKENFPVDINIS 87
            + S  R Q     ++      G           +   P +      +++      + + 
Sbjct: 187 SLDSGTRWQRCRLVLRRAGMPDGEEYVLELFDPPKGSKPKLRAACSAIQEVRRCTRLEMP 246

Query: 88  SKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRR--CHVVFIED 145
             +   + +        F            TD     G     K G  R      +    
Sbjct: 247 DNLHTFVLKVTNATDVLFEAGDEHQLSSYATDVLFEAGDEQPFKPGWPRSGKLAKLESAC 306

Query: 146 VHKLIDVL----------------TTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLH 189
              L   L                +           A          V     + +    
Sbjct: 307 PQMLCPALIPASPIHAGQMWVTLSSCQAGTPIPQPPALLPAPTPQAKVSTRGHQEQGRGA 366

Query: 190 RQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQAL-----LKTEGDFLVRQSDHTPGKYV 244
                     P + + +    W+HG +SR  A  L     L+  G FLVRQS+   G+YV
Sbjct: 367 MPGGPPEAAGPKMEQFLSSCPWFHGPISRVKAAQLVQLGGLEGHGVFLVRQSETRRGEYV 426

Query: 245 LSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
           L+           + L    + R +   FS+I+E++ +     + +       
Sbjct: 427 LTFNFQGRAKHLRLSLTERGQCRVQHLRFSSITEMLHHFHRYPIPLECGATCD 479


>UniRef50_UPI0000E479E4 PREDICTED: similar to Sh2d3c-prov protein, partial n=2
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E479E4
          Length = 926

 Score =  113 bits (282), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 43/182 (23%), Positives = 69/182 (37%), Gaps = 23/182 (12%)

Query: 144 EDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP-PMRHRSSLH-------RQSFVS 195
               +++          +      +S   D F+ P P P+R + SL        R+    
Sbjct: 53  PRSPRIVGTPNQTPGSPSRPHFRYSSIPEDHFSKPPPSPIRTKMSLQDMTPEDLRKLLEE 112

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHK 255
             + P  +EDV    W+HG +SRE A+ L++  GDFLVR S   PG +VL+ R       
Sbjct: 113 EFKLP--SEDVRSHAWFHGGISREKAEKLIRENGDFLVRDSISKPGNFVLTVRWKGVSMH 170

Query: 256 HLILL--------DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
            ++              + +     F  I  LI ++V N   V        +   +  PV
Sbjct: 171 FVVNKVVLKAHSPYASVQYQFEKECFDAIPSLIKFYVGNCRPVSQA-----SGAVIQHPV 225

Query: 308 PC 309
             
Sbjct: 226 NR 227


>UniRef50_Q06124 Tyrosine-protein phosphatase non-receptor type 11 n=69
           Tax=Coelomata RepID=PTN11_HUMAN
          Length = 597

 Score =  112 bits (281), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 35/140 (25%), Positives = 63/140 (45%), Gaps = 19/140 (13%)

Query: 182 MRHRSSLHRQSFV-SNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSD 237
           M H   L  ++      + P    D   + W+HG+LS ++A+ LL      G FLVR+S 
Sbjct: 82  MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQ 141

Query: 238 HTPGKYVLSGRTAEN---------EHKHLILLDNHNRVRT-RDRTFSNISELIDYHVNNG 287
             PG +VLS RT ++         +  H+++     +        F ++++L++++  N 
Sbjct: 142 SHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNP 201

Query: 288 MAVRSEGRDRETSLNLIRPV 307
           M          T L L +P+
Sbjct: 202 MV-----ETLGTVLQLKQPL 216



 Score = 99.5 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 27/116 (23%), Positives = 52/116 (44%), Gaps = 10/116 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +  + W+H N++  +A+ LL T   +G FL R S   PG + LS R       H+ + + 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVR-RNGAVTHIKIQNT 59

Query: 263 HNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC--PGSDDI 315
            +         F+ ++EL+ Y++ +   ++         + L  P+ C  P S+  
Sbjct: 60  GDYYDLYGGEKFATLAELVQYYMEHHGQLK---EKNGDVIELKYPLNCADPTSERW 112


>UniRef50_UPI000186E930 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
            RepID=UPI000186E930
          Length = 1195

 Score =  112 bits (281), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 29/112 (25%), Positives = 58/112 (51%), Gaps = 10/112 (8%)

Query: 201  TVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
              +  +  + WYHG+++R +A+ LL+   EG +LVR S+     Y LS ++A+      I
Sbjct: 1084 DPSLPLEKQTWYHGSITRVEAEDLLRSLKEGSYLVRNSESAKQDYSLSLKSAKGFMHMRI 1143

Query: 259  LLDNH-NRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             +DN+  +       + F++I ++I ++  N + +R         + L++PV
Sbjct: 1144 QIDNNSGQFILGQFSKPFNSIPDMIRHYSVNKLPIRGA-----EHMCLLKPV 1190


>UniRef50_P20936 Ras GTPase-activating protein 1 n=55 Tax=Euteleostomi
           RepID=RASA1_HUMAN
          Length = 1047

 Score =  112 bits (281), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 34/128 (26%), Positives = 53/128 (41%), Gaps = 17/128 (13%)

Query: 186 SSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGK 242
                +       AP   +      WYHG L R  A+  L+     G +L+R+SD  PG 
Sbjct: 162 PEYEEEEVAIPLTAPPTNQ------WYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGS 215

Query: 243 YVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLN 302
           +VLS  +  N   H  ++          R FS++S+LI Y+ +    ++ E         
Sbjct: 216 FVLSFLSQMNVVNHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGE--------K 267

Query: 303 LIRPVPCP 310
           L+ PV  P
Sbjct: 268 LLYPVAPP 275



 Score = 97.1 bits (240), Expect = 8e-19,   Method: Composition-based stats.
 Identities = 36/115 (31%), Positives = 56/115 (48%), Gaps = 12/115 (10%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
             +   GK+W+HG +S+++A  LL T G    FLVR SD+TPG Y L  RT EN  +  I
Sbjct: 342 EEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKI 401

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
               +N+     R +++I ++ID++    +              L  PVP    +
Sbjct: 402 CPTPNNQFMMGGRYYNSIGDIIDHYRKEQIV---------EGYYLKEPVPMQDQE 447


>UniRef50_UPI000180D3EC PREDICTED: similar to fer (fps/fes related) tyrosine kinase n=1
           Tax=Ciona intestinalis RepID=UPI000180D3EC
          Length = 835

 Score =  112 bits (280), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 25/115 (21%), Positives = 51/115 (44%), Gaps = 5/115 (4%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
               ++ +  + W+HG + R ++  LL+ +GDFL+R+S+++ G +VLS +         +
Sbjct: 458 PMDQSKTIKEQTWFHGTIPRTESLRLLQQDGDFLLRESNNSLGDFVLSAKADGQVRHFKV 517

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
            + ++   R     F  +  LI +H      V        T+  L+ P+      
Sbjct: 518 QVTDNGMYRFEADQFPTVLNLISHHYQKREPVTKR-----TNCLLLNPICKDKWQ 567


>UniRef50_UPI0001793081 PREDICTED: similar to AGAP003651-PA, partial n=1 Tax=Acyrthosiphon
           pisum RepID=UPI0001793081
          Length = 770

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 33/157 (21%), Positives = 59/157 (37%), Gaps = 9/157 (5%)

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
           + ++     N  +          P+    +       S     +  + ++ + W+HG L 
Sbjct: 486 HYHSDSLDGNDGSVIVDMRPIVTPVPFADNNSNNFLPS--VIGSSVKSLIEEEWFHGVLP 543

Query: 218 REDAQALLKTEGDFLVRQSDHTP-GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNI 276
           RE+   LL  EGDFLVR++      + VLS          ++   +    R    +F  I
Sbjct: 544 REEVVRLLTKEGDFLVRETTRNDENQTVLSVCW-GGHKHFIVQTTSEGEFRFEGPSFPTI 602

Query: 277 SELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
            ELI Y   + + V S      +   L +P+P    +
Sbjct: 603 QELITYQYQSALPVTSR-----SGAILRQPIPRERWE 634


>UniRef50_P03949 Tyrosine-protein kinase abl-1 n=6 Tax=Chromadorea RepID=ABL1_CAEEL
          Length = 1224

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 45/271 (16%), Positives = 89/271 (32%), Gaps = 31/271 (11%)

Query: 59  TAAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGT 118
             A   + + S++  E+++   P+ + +S +    ++  R          S  +  +   
Sbjct: 27  PVASPKSEISSKLAEEIERSKSPLILEVSPRTPDSVQMFRPTFDTFRPPNSDSSTFRGSQ 86

Query: 119 DTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTA----INVNTFDAQANASTSNDG 174
             E +    + N        + V           +       +       +        G
Sbjct: 87  SREDLVACSSMNSVNNVHDMNTVSSSSSSSAPLFVALYDFHGVGEEQLSLRKGDQVRILG 146

Query: 175 FTVPAPPMRHR-------------SSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDA 221
           +         R                      SN  AP  +  +    WYHG +SR D+
Sbjct: 147 YNKNNEWCEARLYSTRKNDASNQRRLGEIGWVPSNFIAPYNS--LDKYTWYHGKISRSDS 204

Query: 222 QALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN-HNRVRTRDRTFSNISE 278
           +A+L +   G FLVR+S+ + G+Y +S R       + I +DN      T++  F  + E
Sbjct: 205 EAILGSGITGSFLVRESETSIGQYTISVRHDGRVFHYRINVDNTEKMFITQEVKFRTLGE 264

Query: 279 LIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           L+ +H  +   +            L+ P   
Sbjct: 265 LVHHHSVHADGLI---------CLLMYPASK 286


>UniRef50_Q7M4L6 SH2 domain-containing adapter protein F n=21 Tax=Amniota
           RepID=SHF_HUMAN
          Length = 480

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 29/158 (18%), Positives = 66/158 (41%), Gaps = 16/158 (10%)

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTE-------DVVGKVWYH 213
            F+    +  S         P R  +   + +   +    +           +  +VWYH
Sbjct: 323 QFEGPEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYH 382

Query: 214 GNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDR 271
           G +SR DA+ LL+   E  +LVR S+ +   + LS ++++      +    +N+      
Sbjct: 383 GAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKNNKYVLGQN 442

Query: 272 T--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           +  FS++ E++ ++ +  + ++         ++L+ PV
Sbjct: 443 SPPFSSVPEIVHHYASRKLPIKGA-----EHMSLLYPV 475


>UniRef50_UPI0000585FD4 PREDICTED: similar to Abl1 protein n=2 Tax=Eumetazoa
           RepID=UPI0000585FD4
          Length = 1063

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 30/126 (23%), Positives = 49/126 (38%), Gaps = 14/126 (11%)

Query: 187 SLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYV 244
           +            P  +  +    WYHG +SR  A+ LL +  +G FLVR S+ +PG   
Sbjct: 165 NGKTGWVPVTYVTPFNS--LEKHSWYHGPISRNAAEYLLSSGIDGSFLVRDSESSPGHRS 222

Query: 245 LSGRTAENEHKHLILLDNHNR-VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNL 303
           +S R     + + I   +  +   T +  FS I+EL+ +H      +            L
Sbjct: 223 ISLRFDGRVYHYRISSGSDGKVFVTTESKFSTIAELVHHHCKQSDGLI---------TTL 273

Query: 304 IRPVPC 309
             P   
Sbjct: 274 RYPAAK 279


>UniRef50_UPI000186F2CC Phosphatidylinositol 3-kinase regulatory subunit alpha, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186F2CC
          Length = 726

 Score =  112 bits (279), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 32/185 (17%), Positives = 65/185 (35%), Gaps = 11/185 (5%)

Query: 133 GTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQS 192
             ++   VV     H  I  L               S        P    R     +R  
Sbjct: 248 SWEQFNQVVHNLQAHIRILELLLLHGDWGEKLPEFMSAPILP---PRKVSRPGPHPYRDD 304

Query: 193 FVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTA 250
                   +  + +    WY G+++RE+    L    +G FLVR + +  G+Y L+ R  
Sbjct: 305 LELERDRDSAQQQLKDAEWYWGDITREEVNEKLMNTPDGTFLVRNASNKGGEYTLTLR-K 363

Query: 251 ENEHKHLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
              +K + +   + +    +   F+++ EL+ ++  + +       +    + L+ PV  
Sbjct: 364 GGTNKLIKICHKNGKYGFSEPYKFNSVVELVKFYKTSSL----AQYNSTLDIKLLYPVSR 419

Query: 310 PGSDD 314
              +D
Sbjct: 420 FQQED 424



 Score = 84.0 bits (206), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 30/129 (23%), Positives = 45/129 (34%), Gaps = 17/129 (13%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKV------WYHGNLSREDAQALL--KTEGDFLVRQSDHTP 240
                    R     E++          W     SR  A  LL  K EG FLVR S    
Sbjct: 583 PESLTPWGLRELETDENLKSMPHQNEYLWNLPECSRAQAATLLESKPEGTFLVRPSSS-- 640

Query: 241 GKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRE 298
           G+Y LS         H I+          +    + ++ +L+ ++ NN +    E  + E
Sbjct: 641 GQYALSIVCN-GVINHCIIYQTDRGFGFAEPYNIYPSLKQLVLHYANNSL----EEHNEE 695

Query: 299 TSLNLIRPV 307
               L+ PV
Sbjct: 696 LKTTLMYPV 704


>UniRef50_B7PL19 Src tyrosine kinase, putative n=1 Tax=Ixodes scapularis
           RepID=B7PL19_IXOSC
          Length = 447

 Score =  111 bits (278), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 30/130 (23%), Positives = 49/130 (37%), Gaps = 16/130 (12%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDH 238
           R +S+       SN  A   +  +  + WY G + R +A+  L       G FLVR S+ 
Sbjct: 121 RSKSTKQEGYIPSNYVAKLKS--IEAEPWYFGKIKRIEAEKKLLLPENEHGAFLVRDSES 178

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDR 297
               + LS R  +    + I   +        R TF  + EL+D++              
Sbjct: 179 RRNDFSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVDHY---------GNEAD 229

Query: 298 ETSLNLIRPV 307
              +NL +P 
Sbjct: 230 GLCVNLRKPC 239


>UniRef50_Q9NRF2 SH2B adapter protein 1 n=30 Tax=Mammalia RepID=SH2B1_HUMAN
          Length = 756

 Score =  111 bits (278), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 31/160 (19%), Positives = 64/160 (40%), Gaps = 6/160 (3%)

Query: 148 KLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMR-HRSSLHRQSFVSNCRAPTVTEDV 206
             +++L   +       +   + +    + P PP+    ++     F          + +
Sbjct: 463 DSMELLPPELPPRIPIEEGPPAGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPL 522

Query: 207 VGKVWYHGNLSREDAQALLK-----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
            G  W+HG LSR  A  L+      + G FLVRQS+   G+YVL+           + L+
Sbjct: 523 SGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLN 582

Query: 262 NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSL 301
              + R +   F +I +++++   + + + S G      +
Sbjct: 583 EEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGSSDVVLV 622


>UniRef50_P00521 Tyrosine-protein kinase transforming protein Abl n=30 Tax=root
           RepID=ABL_MLVAB
          Length = 746

 Score =  111 bits (277), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 27/107 (25%), Positives = 48/107 (44%), Gaps = 12/107 (11%)

Query: 206 VVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
           +    WYHG +SR  A+ LL +   G FLVR+S+ +PG+  +S R     + + I   + 
Sbjct: 8   LEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASD 67

Query: 264 NR-VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            +   + +  F+ ++EL+ +H      +            L  P P 
Sbjct: 68  GKLYVSSESRFNTLAELVHHHSTVADGLI---------TTLHYPAPK 105


>UniRef50_Q4S224 Chromosome undetermined SCAF14764, whole genome shotgun sequence
           n=2 Tax=Deuterostomia RepID=Q4S224_TETNG
          Length = 486

 Score =  111 bits (277), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 20/141 (14%)

Query: 182 MRHRSSLHRQSFV-SNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSD 237
           M H   L  ++      + P    D   + W+HG+LS  +A+ LL      G FLVR+S 
Sbjct: 82  MEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGREAEKLLTEKGKNGSFLVRESQ 141

Query: 238 HTPGKYVLSGRTAE----------NEHKHLILLDNHNRVRT-RDRTFSNISELIDYHVNN 286
             PG +VLS RT +               +I   +  +        F ++++L++++  N
Sbjct: 142 SHPGDFVLSVRTGDDKTDSSDSKPKVTHVMIRCQHDLKYDVGGGEKFDSLTDLVEHYKKN 201

Query: 287 GMAVRSEGRDRETSLNLIRPV 307
            M          T L L +P+
Sbjct: 202 PMV-----ETLGTVLQLKQPL 217



 Score =  100 bits (248), Expect = 8e-20,   Method: Composition-based stats.
 Identities = 27/116 (23%), Positives = 52/116 (44%), Gaps = 10/116 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +  + W+H N++  +A+ LL T   +G FL R S   PG + LS R       H+ + + 
Sbjct: 1   MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVR-RNGAVTHIKIQNT 59

Query: 263 HNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC--PGSDDI 315
            +         F+ ++EL+ Y++ +   ++         + L  P+ C  P S+  
Sbjct: 60  GDYYDLYGGEKFATLAELVQYYMEHHGQLK---EKNGDVIELKYPLNCADPTSERW 112


>UniRef50_UPI00016E9884 UPI00016E9884 related cluster n=7 Tax=Takifugu rubripes
           RepID=UPI00016E9884
          Length = 843

 Score =  111 bits (276), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 48/309 (15%), Positives = 97/309 (31%), Gaps = 32/309 (10%)

Query: 22  TYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRV----IGEVKK 77
            + GS+  + S +     ++              VG  +  +I P +         E+  
Sbjct: 2   KWFGSLTNLTSRHSEKPNIKATSGR---SESLTAVGGQSVDDIEPCLQSPNYAHSDEMYT 58

Query: 78  ENFPVDINISSK----MIKIIKQSRLIQR-----HPFSFFSFGAQGQKGTDTELMFGYIA 128
               +  + S K     +K  K SR +        P    S     +K  D      +  
Sbjct: 59  HVGTIPRSQSQKKSCREMKQKKTSRPLPCTPAPGRPSPLTSPADHCRKPLDHTE-VLWTE 117

Query: 129 KNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSL 188
            +   T+                 L    + +     A+ S     F+     +   S  
Sbjct: 118 TDVSDTNSCVRKPSNMTKAASPQDLIEDPHEDNLKGSADTSGDYVKFSKDKFWLEPPSEN 177

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGR 248
            ++      R      ++    WYHG +  E A++L+   G+FL+R S    G +VL+  
Sbjct: 178 LKKQLDDELR--LSGTNLKSHAWYHGPVPWEVAESLVVNHGEFLIRDSRSNHGDFVLTCH 235

Query: 249 TAENEHKHLILLD--------NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
             +     LI              +    +  F ++  L+ ++V +  A+      + + 
Sbjct: 236 WQQKTLHFLIRRTVLQSSETYTRVQYSLEEEAFDSLPALVHFYVGSKAALT-----QWSG 290

Query: 301 LNLIRPVPC 309
             + RP+  
Sbjct: 291 AQIHRPINR 299


>UniRef50_D1H0Y8 Abl kinase 2 n=1 Tax=Schistosoma mansoni RepID=D1H0Y8_SCHMA
          Length = 1308

 Score =  111 bits (276), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 27/115 (23%), Positives = 50/115 (43%), Gaps = 12/115 (10%)

Query: 198 RAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHK 255
           +       +  + WYHG + R  A+ LL +   G FL+R+S+  PG+  +S R       
Sbjct: 154 QGSLARVGLESEKWYHGAIQRSYAEYLLNSGITGSFLIRESESHPGQLTISLRYEGQIWH 213

Query: 256 HLILLDNHNRVR-TRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           + I  D+ N         F+++S+L+ +H  +   +         +  L+ P P 
Sbjct: 214 YRIHRDDSNMYYVIESNKFTSVSDLVHHHEKHSDGL---------ACTLLYPAPK 259


>UniRef50_UPI0000E47E92 PREDICTED: similar to fer (fps/fes related) tyrosine kinase
           (phosphoprotein NCP94), partial n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E47E92
          Length = 527

 Score =  111 bits (276), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 37/161 (22%), Positives = 68/161 (42%), Gaps = 7/161 (4%)

Query: 154 TTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYH 213
           +  +N +T       S  ++         + R+        SN +       +  + +YH
Sbjct: 152 SPNLNSSTDSTTEQKSKRSNMANKMTKIFKVRAGHDSSHEPSNNQP--TELRLEEEEFYH 209

Query: 214 GNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTF 273
           G L R++ +ALL  +GDF+VR+     G+YVLS + A       I +++ N  R     F
Sbjct: 210 GALPRKETEALLVNDGDFVVREKSDAWGRYVLSAKHASKVRHFPIQINDENMYRLEGDAF 269

Query: 274 SNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDD 314
             + ELI + +N+   V        +   L++PV    ++ 
Sbjct: 270 QTVGELIRFQLNSRQPVTKA-----SQAILLKPVCRVRNEH 305


>UniRef50_B0V0X4 Novel protein similar to vertebrate NCK adaptor protein 1 (NCK1)
           (Fragment) n=2 Tax=Danio rerio RepID=B0V0X4_DANRE
          Length = 331

 Score =  110 bits (275), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 9/128 (7%)

Query: 184 HRSSLHRQSFVSNCR-APTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHT 239
           H+         SN    P++     GK WY+G L+R  A+ +L     +GDFL+R S+  
Sbjct: 208 HKELGISGPHPSNYDIKPSMDGKFGGKQWYYGKLTRHQAEMVLNQRGVDGDFLIRDSESM 267

Query: 240 PGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
           P  + +S +     +KH  +L N        R FS + +L++++    +     G     
Sbjct: 268 PNDFSISLKALYK-NKHFKVLLNDGFFCIGQRKFSTMEDLVEHYKKAPIFTSEHGD---- 322

Query: 300 SLNLIRPV 307
            L LI+P+
Sbjct: 323 KLYLIKPL 330


>UniRef50_P07947 Proto-oncogene tyrosine-protein kinase Yes n=297 Tax=root
           RepID=YES_HUMAN
          Length = 543

 Score =  110 bits (275), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 32/144 (22%), Positives = 58/144 (40%), Gaps = 13/144 (9%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD----FLVRQS 236
             R  ++       SN  AP   + +  + WY G + R+DA+ LL   G+    FLVR+S
Sbjct: 130 EARSIATGKNGYIPSNYVAPA--DSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRES 187

Query: 237 DHTPGKYVLSGRT----AENEHKHLILL--DNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           + T G Y LS R       +  KH  +   DN     T    F  + +L+ ++  +   +
Sbjct: 188 ETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGL 247

Query: 291 RSEGRDRETSL-NLIRPVPCPGSD 313
             +      ++    + +     +
Sbjct: 248 CHKLTTVCPTVKPQTQGLAKDAWE 271


>UniRef50_UPI000186CA05 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase, putative
           n=1 Tax=Pediculus humanus corporis RepID=UPI000186CA05
          Length = 1274

 Score =  110 bits (275), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 34/138 (24%), Positives = 58/138 (42%), Gaps = 19/138 (13%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS--REDAQALLKT-----EGDFLVRQSD 237
           R     +   S   +    E    ++W+HG L   R +A++LLK      +G FLVR+S+
Sbjct: 569 RHKEVNKFTFSISLSVPNDELHFSEMWFHGKLGGKRAEAESLLKKYSHLGDGTFLVRESE 628

Query: 238 HTPGKYVLSGRTAENEHKHLILLDNHN-----RVRTRDRTFSNISELIDYHVNNGMAVRS 292
              G Y LS    + +  H  +    +            +F ++  LI Y+ ++ +    
Sbjct: 629 TFVGDYSLSF-WRQGKVNHCRIRSKQDKGQTKYYLIDTNSFDSLYSLITYYRSHPL---- 683

Query: 293 EGRDRETSLNLIRPVPCP 310
             R +E  + L  PVP P
Sbjct: 684 --RSQEFLIVLKEPVPQP 699



 Score = 99.5 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 37/201 (18%), Positives = 65/201 (32%), Gaps = 21/201 (10%)

Query: 110 FGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANAS 169
           +   G           ++        R+  V       K     T    ++T    +  S
Sbjct: 614 YSHLGDGTFLVRESETFVGDYSLSFWRQGKVNHCRIRSKQDKGQTKYYLIDTNSFDSLYS 673

Query: 170 TSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT-- 227
                        R      ++  +             GK WY  N++R  A+ +LK   
Sbjct: 674 LITYY--------RSHPLRSQEFLIVLKEPVPQPNKHEGKEWYLPNVTRSQAEEMLKRVP 725

Query: 228 -EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNN 286
            +G FLVR S+     Y +S R AE + KH  +  +          F ++ +LI Y+  +
Sbjct: 726 TDGAFLVRPSERGANSYAISFR-AEKKIKHCRIKVDGRLYAIGSVYFESLVDLITYYERH 784

Query: 287 GMAVRSEGRDRETSLNLIRPV 307
            +  +         + L  PV
Sbjct: 785 PLYKK---------IRLCHPV 796


>UniRef50_Q4TEC1 Chromosome undetermined SCAF5507, whole genome shotgun sequence.
           (Fragment) n=11 Tax=Clupeocephala RepID=Q4TEC1_TETNG
          Length = 1116

 Score =  110 bits (275), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 36/139 (25%), Positives = 60/139 (43%), Gaps = 11/139 (7%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHT 239
               L       N  AP  +     + W+ G L+R  AQ+ L     +EG FL+R S+  
Sbjct: 44  SGRVLDSGLVPGNYLAPAESG--QTQPWFFGTLNRLQAQSHLLAPENSEGAFLIRVSEKD 101

Query: 240 PGKYVLSGRTAENEHKHLILLDNHNRVRTR-DRTFSNISELIDYHVNNGM----AVRSEG 294
              YVLS R+ +    + +L  + NR      R FS+++EL+DY+    +     + +  
Sbjct: 102 NVGYVLSVRSGDQVKHYKVLQTDQNRFYVEPGRRFSSLAELVDYYQKTSLNNAGPLGNPC 161

Query: 295 RDRETSLNLIRPVPCPGSD 313
           +    S   + P P  G +
Sbjct: 162 KRNTLSTPALLPFPTIGWE 180



 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 34/145 (23%), Positives = 54/145 (37%), Gaps = 15/145 (10%)

Query: 170 TSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL---- 225
             +   +   PP   +              P  T       WY+GN++R  A+ LL    
Sbjct: 216 LKSAAVSKLVPPDSPQGDGRMPD-------PLGTSLGWTGPWYYGNINRVKAEKLLLASQ 268

Query: 226 KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDR-TFSNISELIDYHV 284
             +G FLVR S+    +Y +S R+        I   +       DR +F+ + ELI Y+ 
Sbjct: 269 NKDGSFLVRISESHSDEYTISARSEGKVFHFRIQRSSIGAYFVSDRISFATLGELISYYQ 328

Query: 285 NNGMAVRSEGRDRETSLNLIRPVPC 309
            N  ++   G   E      RP+  
Sbjct: 329 RNNRSL---GVLLEEPCAQQRPLTP 350



 Score = 92.9 bits (229), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 25/93 (26%), Positives = 44/93 (47%), Gaps = 5/93 (5%)

Query: 226 KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTR-DRTFSNISELIDYHV 284
            +EG FL+R S+     YVLS R+ +    + +L  + NR      R FS+++EL+DY+ 
Sbjct: 733 NSEGAFLIRVSEKDNVGYVLSVRSGDQVKHYKVLQTDQNRFYVEPGRRFSSLAELVDYYQ 792

Query: 285 NNGM----AVRSEGRDRETSLNLIRPVPCPGSD 313
              +     + +  +    S   + P P  G +
Sbjct: 793 KTSLNNAGPLGNPCKRNTLSTPALLPFPTIGWE 825


>UniRef50_Q08BY6 Zgc:153964 n=2 Tax=Danio rerio RepID=Q08BY6_DANRE
          Length = 511

 Score =  110 bits (275), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 34/120 (28%), Positives = 56/120 (46%), Gaps = 9/120 (7%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTE----GDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
            + V  + W+ G ++R  A + L ++    G FLVR S+     YVLS RT EN     I
Sbjct: 126 RDSVESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENAKHFKI 185

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP--VPCPGSDDIE 316
                         FS+I E+I+++ ++ +++   G         I+P  VP P +D+ E
Sbjct: 186 FQTGDQFYVDALFKFSSIVEVIEHYQSHPLSI---GDLLSEPCIRIKPENVPPPSTDEWE 242


>UniRef50_B4H4I2 GL18226 n=1 Tax=Drosophila persimilis RepID=B4H4I2_DROPE
          Length = 431

 Score =  110 bits (274), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 43/207 (20%), Positives = 79/207 (38%), Gaps = 24/207 (11%)

Query: 113 QGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSN 172
            G +  D       +A      D   H + +  ++  ID     I       +      +
Sbjct: 242 GGDEFNDLASEDEAVA-----NDLDMHALILNGLNGDIDD--QPIKTVEEVIKEIDDIMD 294

Query: 173 DGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EG 229
           +  +    P    S +  ++      AP   +      W+H  +S  +A+ LL+    +G
Sbjct: 295 EAESPLDEPDTCESEVIEKAREVLGGAPVRRK------WFHPTISGIEAEKLLQEEGFDG 348

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT-RDRTFSNISELIDYHVNNGM 288
            FL R S   PG + LS R   NE  H+ + +N +         F+ + EL+ Y++ NG 
Sbjct: 349 SFLARLSSSNPGAFTLSVR-RGNEVTHIKIQNNGDFFDLYGGEKFATLPELVQYYMENGE 407

Query: 289 AVRSEGRDRETSLNLIRPVPC--PGSD 313
                G+     + L +P+ C  P ++
Sbjct: 408 LKEKNGQA----IELKQPLICAEPTTE 430


>UniRef50_B0X2Z7 Signal transduction protein lnk-realted n=2 Tax=Culicidae
           RepID=B0X2Z7_CULQU
          Length = 591

 Score =  110 bits (274), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 42/218 (19%), Positives = 76/218 (34%), Gaps = 18/218 (8%)

Query: 104 PFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFD 163
                S        + T    G      + +    H            + ++ +N     
Sbjct: 321 QLPPISDLTGA-NQSVTTPGQGQGQGQHNNSTSISHGGGGGGGGGGGGLSSSLVNEVNNL 379

Query: 164 AQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVT------------EDVVGKVW 211
              N S  N   T+ AP +  R    R S  SN                     +    W
Sbjct: 380 TLNNQSALNAVPTMMAPELPPRRPDDRISSSSNFELTETDLEPAHETDTDLTAMMREYPW 439

Query: 212 YHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
           +HG L+R +A  L+      + G FLVRQS+   G++VL+           + L++  + 
Sbjct: 440 FHGTLARSEAAQLVLHNGISSHGVFLVRQSETRKGEFVLTFNFQGKAKHLRMTLNDLGQC 499

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
           R +   F +I+E++++   + + + S G    T  N +
Sbjct: 500 RVQHLWFPSITEMLEHFRQHAIPLESGGTADVTLTNFV 537


>UniRef50_UPI00017B55E8 UPI00017B55E8 related cluster n=2 Tax=Tetraodon nigroviridis
           RepID=UPI00017B55E8
          Length = 497

 Score =  110 bits (274), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 35/263 (13%), Positives = 78/263 (29%), Gaps = 27/263 (10%)

Query: 58  VTAAREINPVVSRVIGEVKKEN----FPVDINISSKMIKIIKQSRLIQRHPF-----SFF 108
               +  +P ++    ++++        +  NI++ ++K+++Q   I          S+ 
Sbjct: 235 YDPPKASSPKLTSQCSDIQEVRRCNRLEMPDNINTFVLKVVRQGSWIFETDNDQQVSSWT 294

Query: 109 SFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVN-------- 160
           +   +     DTE+                                  +           
Sbjct: 295 TEIKECVNNRDTEVASCLSGAAAFNLQNSAVSPRCPSTSSSAGADVEPLPTTPDFTAPAG 354

Query: 161 -----TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGN 215
                    Q+   +S  G          R +                  +    W+HG 
Sbjct: 355 HRGSAELGGQSKTRSSRPGSGFLGLIPSLRPADPASLPPPEPAVQKTDHFLFSYPWFHGP 414

Query: 216 LSREDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD 270
           +SR  A  L+++      G FLVRQS+   G YVL+           + L    + R + 
Sbjct: 415 ISRVKAAHLVQSSGPEGHGVFLVRQSETRRGDYVLTFNYQGKAKHLRLSLTEWGQCRVQH 474

Query: 271 RTFSNISELIDYHVNNGMAVRSE 293
             F ++ +++ +     + +   
Sbjct: 475 LRFPSVMDMLSHFRLYPIPLECG 497


>UniRef50_UPI000192575E PREDICTED: similar to fyn-related kinase n=1 Tax=Hydra
           magnipapillata RepID=UPI000192575E
          Length = 521

 Score =  110 bits (274), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 31/136 (22%), Positives = 61/136 (44%), Gaps = 20/136 (14%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK----TEGDFLVRQSDH 238
           R R +  +     N  AP   + +  + WY G++ R DA+ LL      +G FL+R+S++
Sbjct: 103 RSRKNGKKGYIPGNYVAPI--QTLEAEPWYFGDIKRHDAEKLLMQIGSQDGSFLIRKSEN 160

Query: 239 TPGK----YVLSGRTAENEHKHLILLDNHNRVRTR-DRTFSNISELIDYHVNNGMAVRSE 293
             G+    + LS R  E    + I + +  +      + FS ++ELI+++  +   ++  
Sbjct: 161 KNGQVSNCFALSVRDKELIRHYRIKITDSGKYFISLSKEFSTLNELIEFYKISSDGLK-- 218

Query: 294 GRDRETSLNLIRPVPC 309
                  + L+ P   
Sbjct: 219 -------IKLLEPCRK 227


>UniRef50_O77132 Non-receptor protein-tyrosine kinase CSK n=2 Tax=Hydra
           RepID=O77132_HYDAT
          Length = 467

 Score =  110 bits (274), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 27/133 (20%), Positives = 51/133 (38%), Gaps = 15/133 (11%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTP 240
           +  S         N         +    W+ G ++RE A+ LL  +  G FLVR+S + P
Sbjct: 64  KKVSDGRTGLIPINYVQQRRALHLHEMPWFFGKITREKAEELLTPREVGLFLVRESTNFP 123

Query: 241 GKYVLSGRT---AENEHKHLILLDNHNRVRTRDRT-FSNISELIDYHVNNGMAVRSEGRD 296
           G Y L   +    +    + ++  + N+V   +   F  + ELI ++  +   +      
Sbjct: 124 GDYTLCVVSPQNNKKVEHYRVISTSDNQVTVDEEAFFPTLIELIKHYEKDADGLC----- 178

Query: 297 RETSLNLIRPVPC 309
                 L +P+  
Sbjct: 179 ----TMLKKPLKK 187


>UniRef50_UPI00017B392D UPI00017B392D related cluster n=2 Tax=Tetraodon nigroviridis
           RepID=UPI00017B392D
          Length = 610

 Score =  110 bits (274), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 37/158 (23%), Positives = 67/158 (42%), Gaps = 5/158 (3%)

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFV-SNCRAPTVTEDVVGKVWYHGNLSRE 219
                +++     G  +  P      +    SF+ S+  A  V   +    W+HG LSR 
Sbjct: 416 APLEDSDSRLVVGGSGLGTPLAETPDAGGEGSFLFSDPVAEAVEHPLSECQWFHGTLSRL 475

Query: 220 DAQALLK----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSN 275
            A  L+     + G FLVRQS+   G+YVL+           + L+   + R +   F +
Sbjct: 476 KAAQLVLGGPASHGVFLVRQSETRRGEYVLTFNFQGKAKALRLSLNEDGQCRVQHLWFQS 535

Query: 276 ISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           I +++++   + + + S G    T ++ +  V  PG D
Sbjct: 536 IFDMLEHFRVHPIPLESGGASDVTLVSFVGAVRQPGRD 573


>UniRef50_UPI00015B62FA PREDICTED: similar to ras gtpase activating protein n=1 Tax=Nasonia
           vitripennis RepID=UPI00015B62FA
          Length = 879

 Score =  109 bits (273), Expect = 9e-23,   Method: Composition-based stats.
 Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 12/106 (11%)

Query: 208 GKVWYHGNLSREDAQALLKTE---GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
              WYHG L R  A+  L+     G +LVR+SD  PG YVLS         H  +     
Sbjct: 74  ENQWYHGRLDRFTAEERLRDASRLGSYLVRESDRKPGSYVLSYLGRTG-INHFRITAVCG 132

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
                 R F+++ +L+ Y+ +    ++ E         LI P P P
Sbjct: 133 DYYIGGRQFNSLMDLVAYYTHCSDLLKKE--------RLIHPTPPP 170



 Score = 73.3 bits (178), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 22/83 (26%), Positives = 38/83 (45%), Gaps = 3/83 (3%)

Query: 209 KVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
             W+H N+++ +A  +L     G FLVR SD++PG Y L      N+ +   +     R 
Sbjct: 244 FSWFHPNVTKSEAVDMLVKAGPGSFLVRPSDNSPGDYSL-FFHINNQIQRFRIEKKGVRY 302

Query: 267 RTRDRTFSNISELIDYHVNNGMA 289
               RTF  +  +I+ +    + 
Sbjct: 303 LMGGRTFECLDAVINRYRKEQIV 325


>UniRef50_Q2VXS8 Proto-oncogene c-fes variant 3 n=17 Tax=Eutheria RepID=Q2VXS8_HUMAN
          Length = 764

 Score =  109 bits (273), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 40/190 (21%), Positives = 69/190 (36%), Gaps = 22/190 (11%)

Query: 138 CHVVFIEDVHKLIDVLTTAINVNTF--------DAQANASTSNDGFTVPAPPMRHRSSLH 189
           C    ++   +L+      +             D  + +S+  +      P +    S  
Sbjct: 314 CSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEILKSHI 373

Query: 190 RQSF-------VSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGK 242
              F             P V + +  ++WYHG + R +   LL   GDFLVR+S     +
Sbjct: 374 SGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQGKQ-E 432

Query: 243 YVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLN 302
           YVLS    +   +H I+    N  R     F +I  LID+ ++    +       ++ + 
Sbjct: 433 YVLSVLW-DGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTK-----KSGVV 486

Query: 303 LIRPVPCPGS 312
           L R VP    
Sbjct: 487 LHRAVPKDKW 496


>UniRef50_A1L2D2 Src homology 2 domain containing transforming protein D n=8
           Tax=Clupeocephala RepID=A1L2D2_DANRE
          Length = 391

 Score =  109 bits (273), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 35/154 (22%), Positives = 60/154 (38%), Gaps = 17/154 (11%)

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
              T   + + +    G      P    S +  +   S          +  +VWYHG+LS
Sbjct: 246 CSPTERLRCSRAPPTTGSMKLRKPSDPHSMIGERVDPS--------LPLEKQVWYHGSLS 297

Query: 218 REDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--F 273
           R +A++LL    E  +LVR S+ +   Y LS R+ +             R      +  F
Sbjct: 298 RSEAESLLTLCKECSYLVRNSETSRLDYSLSLRSCQGFMHMKFSQCKDGRYILGQNSPPF 357

Query: 274 SNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             I E+I Y+  + + ++         L+L+ PV
Sbjct: 358 ETIPEVIHYYTTHKLPIKGA-----EHLSLLFPV 386


>UniRef50_Q9V9J3 Tyrosine-protein kinase Src42A n=25 Tax=Fungi/Metazoa group
           RepID=SRC42_DROME
          Length = 517

 Score =  109 bits (272), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 26/145 (17%), Positives = 51/145 (35%), Gaps = 16/145 (11%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQS 236
             R + +       SN  A   +  +  + WY   + R +A+  L       G FL+R S
Sbjct: 102 LARSKKTRSEGYIPSNYVAKLKS--IEAEPWYFRKIKRIEAEKKLLLPENEHGAFLIRDS 159

Query: 237 DHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGR 295
           +     Y LS R  +    + I   +        R TF  + EL++++  +   +     
Sbjct: 160 ESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLC--VN 217

Query: 296 DRETSLNLIRPV-------PCPGSD 313
             +  + + +PV            +
Sbjct: 218 LCKPCVQIEKPVTEGLSHRTRDQWE 242


>UniRef50_O75791 GRB2-related adapter protein 2 n=26 Tax=Chordata RepID=GRAP2_HUMAN
          Length = 330

 Score =  109 bits (272), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 27/112 (24%), Positives = 51/112 (45%), Gaps = 2/112 (1%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLS 246
             +        P    D+    W+H  LSR  A+ LL  K  G F++R S  +PG + +S
Sbjct: 36  KAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSIS 95

Query: 247 GRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
            R  ++     ++ DN          F ++++L+DY+  N ++ + +   R+
Sbjct: 96  VRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRD 147


>UniRef50_Q17MF5 Tyrosine-protein kinase n=2 Tax=Culicini RepID=Q17MF5_AEDAE
          Length = 747

 Score =  109 bits (272), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 27/111 (24%), Positives = 49/111 (44%), Gaps = 11/111 (9%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
            V   +    W+HG + RE+A+ LL  + +G FLVR+S + PG Y L     E    + I
Sbjct: 368 EVNAKLNAMPWFHGRIKREEAENLLKPREDGLFLVRESTNFPGDYTLCVCFNEKVEHYRI 427

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
               +      D  F N+ +L++++  +   +            L++ +P 
Sbjct: 428 KYAENKLTIDDDEYFDNLGQLVEHYTLDSDGLC---------TKLMKALPK 469


>UniRef50_B0X6G7 Tyrosine phosphatase n11 n=7 Tax=Eumetazoa RepID=B0X6G7_CULQU
          Length = 724

 Score =  109 bits (272), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 32/115 (27%), Positives = 53/115 (46%), Gaps = 8/115 (6%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAE 251
           S+         +  + W+HGNLS ++A+ L+      G FLVR+S   PG +VLS RT +
Sbjct: 42  SSDILRLRDLLLRARRWFHGNLSGKEAERLILERGKNGSFLVRESQSKPGDFVLSVRTED 101

Query: 252 NEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
                +I    +       + F  + ELI+++  N M          T ++L +P
Sbjct: 102 KVTHVMIRWHENKYDVGGGQKFGTLCELIEHYKRNPMV-----EICGTVVHLRQP 151


>UniRef50_B3XVY8 Protein tyrosine kinase abl n=1 Tax=Codonosiga gracilis
           RepID=B3XVY8_9EUKA
          Length = 699

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 26/125 (20%), Positives = 45/125 (36%), Gaps = 13/125 (10%)

Query: 191 QSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGR 248
               SN      +  +  + +YHG + R  A+  L     G FLVR+S    G++ +S R
Sbjct: 161 GWVPSNYVVKLNS--LDSEPYYHGRIPRTTAEFFLSNGINGSFLVRESQSNAGEHTISLR 218

Query: 249 TAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
                  + I   +       DR FS + +L+ ++      +            L   VP
Sbjct: 219 CDGKVFHYRISRTDKGVFIAADRVFSTVQDLVKFYHQQSDGLVH---------PLRHAVP 269

Query: 309 CPGSD 313
               +
Sbjct: 270 KNRQE 274


>UniRef50_B7P6T2 Putative uncharacterized protein (Fragment) n=1 Tax=Ixodes
           scapularis RepID=B7P6T2_IXOSC
          Length = 702

 Score =  109 bits (272), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 24/112 (21%), Positives = 43/112 (38%), Gaps = 8/112 (7%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHK 255
                  + D+    WYHG + R+ A+ L+  +G FLVR     PG YVL+         
Sbjct: 13  EWELGLDSRDMRSHAWYHGTIPRQRAEELMTADGGFLVRDCVSRPGDYVLTCCWKGAPLH 72

Query: 256 HLILL--------DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
            +I              + +  D  F  + +L+ ++V N   + +      +
Sbjct: 73  FVINKVVLQPYTVYERIQYQFEDDCFDTVPDLVTFYVGNKRPISAASGAVVS 124


>UniRef50_UPI000186D8F4 conserved hypothetical protein n=1 Tax=Pediculus humanus corporis
           RepID=UPI000186D8F4
          Length = 792

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 36/165 (21%), Positives = 63/165 (38%), Gaps = 10/165 (6%)

Query: 153 LTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWY 212
           +   +    F      S S     + A P         +  +          D+    WY
Sbjct: 17  VREDLGAQEFILNVIQSKSLGNIKMEANPENGLDPAQLRKAL-EWELSLDARDLRSHAWY 75

Query: 213 HGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL--------DNHN 264
           HG++ R  A+ +L+++GDFLVR     PG +VLS +        +I              
Sbjct: 76  HGSIPRTRAEEILESDGDFLVRDCTSQPGNFVLSTKCKGQNLHFVINKVVLQPDTVYERI 135

Query: 265 RVRTRDRTFSNISELIDYHVNNGMAVRS-EGRDRETSLNLIRPVP 308
           + +  D  +  +S+LI Y+V +G  + S  G   +   N + P+ 
Sbjct: 136 QFQFEDEAYDTVSDLITYYVGSGKVISSLSGARIQNPKNRLHPLS 180


>UniRef50_A2AQ87 Src homology 2 domain containing F (Fragment) n=9 Tax=Euteleostomi
           RepID=A2AQ87_MOUSE
          Length = 446

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 29/164 (17%), Positives = 64/164 (39%), Gaps = 15/164 (9%)

Query: 154 TTAINVNTFDAQANASTSNDGFTVPAPP------MRHRSSLHRQSFVSNCRAPTVTEDVV 207
            +      F+   N  +         PP       +    L  +              + 
Sbjct: 283 ISKAFAAQFEGSENCLSPGREEKGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALPLE 342

Query: 208 GKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
            +VWYHG +SR DA+ LL+   E  +LVR S+ +   + LS ++++      +     ++
Sbjct: 343 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 402

Query: 266 VRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                 +  FS++ E++ ++ +  + ++         ++L+ PV
Sbjct: 403 YVLGQNSPPFSSVPEIVHHYASRKLPIKGA-----EHMSLLYPV 441


>UniRef50_UPI00016E7A57 UPI00016E7A57 related cluster n=6 Tax=Takifugu rubripes
           RepID=UPI00016E7A57
          Length = 668

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 31/113 (27%), Positives = 45/113 (39%), Gaps = 13/113 (11%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL---- 260
           D+    WYHG L RE  +ALL+ +GDFLVR S   PG YVL+           I+     
Sbjct: 18  DLKSHAWYHGPLGREAGEALLERDGDFLVRDSSSAPGDYVLTCFWMNGPMHFKIIRVVLR 77

Query: 261 ----DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                +    +  +  F N+  LI +HV +   +               P+  
Sbjct: 78  PKQGYSRELFQFEEDRFDNVPALIRFHVGSRRPISQASSAVIF-----HPITR 125


>UniRef50_O88834 SH2 domain-containing adapter protein D n=8 Tax=Euteleostomi
           RepID=SHD_MOUSE
          Length = 343

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 31/133 (23%), Positives = 50/133 (37%), Gaps = 9/133 (6%)

Query: 179 APPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQS 236
               R   S                  +  + W+HG LSR +A+ LL    EG +LVR S
Sbjct: 193 PDWERTPCSTKEPWRPQPAERVDTALALEKQPWFHGPLSRAEAENLLSLCKEGSYLVRLS 252

Query: 237 DHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--FSNISELIDYHVNNGMAVRSEG 294
           +      +LS R+ +            N+V     +  F +I EL+ ++    + V+   
Sbjct: 253 ETRAQDCILSLRSNQGSMHLKFARTRENQVVLGQHSGPFPSIPELVLHYSARPLPVQGA- 311

Query: 295 RDRETSLNLIRPV 307
                 L L+ PV
Sbjct: 312 ----EHLALLYPV 320


>UniRef50_UPI00017B2C65 UPI00017B2C65 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B2C65
          Length = 846

 Score =  109 bits (271), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 28/169 (16%), Positives = 61/169 (36%), Gaps = 15/169 (8%)

Query: 149 LIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVG 208
             +  +      +    A++S     F+     +   S   ++      R    + ++  
Sbjct: 153 APEEKSPPFMFFSLTGSADSSGEYVKFSKGKFWLEPLSENLKKQLEEELR--LSSTNLKS 210

Query: 209 KVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL-------- 260
             WYHG +  E +++L+   GDFL+R S    G +VL+    +     LI          
Sbjct: 211 HAWYHGPIPWEVSESLVVNHGDFLIRDSQSNRGNFVLTSNWQQKTLHFLIRKAALQPGET 270

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
               +    +  F ++  L+ ++V +   +      + +   + RPV  
Sbjct: 271 YPRVQYSLEEEAFESLPALVHFYVGSRAPLT-----QWSGAQIQRPVNR 314


>UniRef50_B0WI58 Putative uncharacterized protein n=2 Tax=Culicini
           RepID=B0WI58_CULQU
          Length = 825

 Score =  108 bits (270), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 32/156 (20%), Positives = 60/156 (38%), Gaps = 15/156 (9%)

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSRED 220
           +   Q+ +           P   + S   +++          + D+    WYHG + R+ 
Sbjct: 10  SNAKQSKSLGDLLDMETTTPDGGNESVALKKALEWEL--SLDSRDLRSHAWYHGPIPRQR 67

Query: 221 AQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL--------DNHNRVRTRDRT 272
           A+ +++ EGDFLVR     PG YVL+ RT       +I              + +  D  
Sbjct: 68  AEEIVQKEGDFLVRDCVSQPGNYVLTCRTKGPTLHFVINKLLIQPETVYERVQYQFEDDA 127

Query: 273 FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
           +  + +LI ++V +       G   +   N + P+ 
Sbjct: 128 YDTVPDLITFYVGSA-----SGARIQFPCNRLYPLS 158


>UniRef50_A9UXP1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UXP1_MONBE
          Length = 654

 Score =  108 bits (270), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 41/146 (28%), Positives = 61/146 (41%), Gaps = 17/146 (11%)

Query: 169 STSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTED---VVGKVWYHGNLSREDAQALL 225
           S S     V    M       R +       P        +  + W+  + S+  A ALL
Sbjct: 237 SLSKGERLVIVDQMEEHWWKARNNAGQEGYIPANYVRKLGLESEPWFMADTSKAMASALL 296

Query: 226 K---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT-RDRTFSNISELID 281
                +G FLVR+S+ TPG Y LS    + + KH  +  + +  R     TF++ISELI+
Sbjct: 297 NMCGQDGAFLVRESESTPGSYSLSVFY-QGKLKHYKIKHDQDMYRVSERHTFASISELIE 355

Query: 282 YHVNNGMAVRSEGRDRETSLNLIRPV 307
           YH +NG  +            L +PV
Sbjct: 356 YHKHNGGGLV---------TRLRKPV 372


>UniRef50_UPI000180C03D PREDICTED: similar to src kinase n=1 Tax=Ciona intestinalis
           RepID=UPI000180C03D
          Length = 486

 Score =  108 bits (270), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 30/122 (24%), Positives = 55/122 (45%), Gaps = 14/122 (11%)

Query: 195 SNCRAPTVTED---VVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRT 249
           SN  AP V      +    W+HG ++R DA+ LL  + +G FLVR+S + PG Y +    
Sbjct: 89  SNKAAPAVRHKEVKLTAMPWFHGKITRSDAEDLLTPRKDGLFLVRESTNYPGDYTMCVSF 148

Query: 250 AENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           A     + ++  ++      +  F N+++L++++         E         L +P+  
Sbjct: 149 AGEVEHYRVIFKDNKVTIDEEEYFENLTKLVEHY---------ERDADGLVCTLTQPLIK 199

Query: 310 PG 311
            G
Sbjct: 200 KG 201


>UniRef50_UPI000175898D PREDICTED: similar to AGAP009560-PA, partial n=1 Tax=Tribolium
           castaneum RepID=UPI000175898D
          Length = 876

 Score =  108 bits (270), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 36/181 (19%), Positives = 66/181 (36%), Gaps = 20/181 (11%)

Query: 150 IDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGK 209
           I+      N+++      + + N+    P       S   +++          + D+   
Sbjct: 117 IEETDKLSNLSSVYEPVQSKSLNNLIMEPTADPSMNSLELKKALEWEL--SLDSRDLRSH 174

Query: 210 VWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL--------D 261
            WYHG + R  A+ +++ EG FLVR     PG YVL+ RT       +I           
Sbjct: 175 AWYHGAIPRSRAEDIVREEGGFLVRDCTSQPGNYVLTCRTKTQPLHFVINKIILQPDTVY 234

Query: 262 NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRD----------RETSLNLIRPVPCPG 311
            H + +  +  F  + +LI ++V +G  + +                +      P P P 
Sbjct: 235 EHVQFQFEEDAFDTVPDLITFYVGSGKPITAASGARIQFPKNRMYPLSFYAAKYPTPLPQ 294

Query: 312 S 312
           S
Sbjct: 295 S 295


>UniRef50_UPI00015B58E2 PREDICTED: similar to signal transduction protein lnk-realted n=1
           Tax=Nasonia vitripennis RepID=UPI00015B58E2
          Length = 458

 Score =  108 bits (270), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 31/168 (18%), Positives = 56/168 (33%), Gaps = 5/168 (2%)

Query: 139 HVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCR 198
           H +F   + +  +     +  +                   P          + F     
Sbjct: 198 HGIFCSSITEARETTALEMPDHENTFVLKTLEREFIIEAKDPNDMRSWLATIRYFPGAEV 257

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENE 253
              ++  +    W+HG L R DA  L+        G FLVRQS+   G+YVL+       
Sbjct: 258 EVDLSSSLREYPWFHGTLPRSDAAQLVLHNATEGHGTFLVRQSETRKGEYVLTFNFQGRA 317

Query: 254 HKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSL 301
               + L +    R +  +F  I +++D+   N + + S G       
Sbjct: 318 KHLRMTLTDQGHCRVQHLSFPAIYDMLDHFRQNPIPLESGGTADVKLT 365


>UniRef50_UPI0000E46C42 PREDICTED: similar to Grb14 n=2 Tax=Strongylocentrotus purpuratus
           RepID=UPI0000E46C42
          Length = 756

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 31/187 (16%), Positives = 69/187 (36%), Gaps = 7/187 (3%)

Query: 111 GAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANAST 170
           G QG+   +         + +    RR     ++       V T++   N   +   +++
Sbjct: 559 GTQGRVIDNPSEAIAIARQEEFNWRRRGGQRSLDSPLISPRVTTSSPRFNFPPSSGGSNS 618

Query: 171 SNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVG-KVWYHGNLSREDAQALLKT-- 227
            +   +            H  +    CR   +   +   + W+H  L+R++  AL     
Sbjct: 619 PHSQLSSSPRHNNPSPRSHHNTSPGACRRGGINSGIHMTQPWFHSGLTRDETHALFAKQG 678

Query: 228 --EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT--RDRTFSNISELIDYH 283
             +G FL+R+S   PG +VLS    +    + I +              F+++ +L++++
Sbjct: 679 MVDGMFLIRESQRIPGAFVLSFSHNQKVKHYQINMVEDGVYTIDDGGTRFTDLIQLVEFY 738

Query: 284 VNNGMAV 290
             N   +
Sbjct: 739 QLNSGGL 745


>UniRef50_Q4RNX3 Chromosome 10 SCAF15009, whole genome shotgun sequence. (Fragment)
           n=3 Tax=Euteleostomi RepID=Q4RNX3_TETNG
          Length = 466

 Score =  108 bits (270), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 35/148 (23%), Positives = 59/148 (39%), Gaps = 26/148 (17%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQS 236
                ++  R     N  A +    +  + W+  N+SR +A   L     T+G FLVR+S
Sbjct: 89  LAESLTTGQRGYIPYNFIAMST---METEAWFFKNISRNEATRRLMAPGNTQGSFLVRES 145

Query: 237 DHTPGKYVLSGR---TAENEHKHLILL--DNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
           + TPG Y LS R      +  KH  +   DN     T   +F+++ EL+ ++  +   + 
Sbjct: 146 ETTPGSYSLSMRDFDNNGDGVKHYRIRNMDNGGFYITTKISFNSLKELVQHYSRDSDGLC 205

Query: 292 SEGRDRETSLNLIRPV-----PCPGSDD 314
                      L++P        P   D
Sbjct: 206 ---------TKLVKPCQSKAPQKPWWQD 224


>UniRef50_Q7KV33 CG42251, isoform C n=9 Tax=melanogaster subgroup RepID=Q7KV33_DROME
          Length = 1510

 Score =  108 bits (269), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 40/175 (22%), Positives = 62/175 (35%), Gaps = 14/175 (8%)

Query: 142  FIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPT 201
             + D  K+   L TA+         N S                S+      +S      
Sbjct: 1336 SMRDDQKMSSKLDTALFRQNLTLNLNESRQATKQFGSLDLRGLNSNKELNMNLSQGYVTA 1395

Query: 202  VT-----EDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEH 254
            V        +  + WYHG ++R +A+  L+   EG FLVR  + T   Y LS + A+   
Sbjct: 1396 VDLIDVTIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFM 1455

Query: 255  KHLILLDNHNRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
               I  +   +       R F  + E+I +   N + VR         + LI PV
Sbjct: 1456 HMRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGA-----EHMCLIEPV 1505


>UniRef50_A9UWT7 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UWT7_MONBE
          Length = 427

 Score =  108 bits (269), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 44/197 (22%), Positives = 74/197 (37%), Gaps = 17/197 (8%)

Query: 14  SSGV--SLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGV-TAAREINPVVSR 70
             G+  S    Y+GS+ VV+S+  + +  +  +  E I        +    R+  P    
Sbjct: 45  GKGIFYSYPVRYVGSIQVVQSLRSLSTPEKTAICREAINRTGEAAKLIKVKRKAPPRAKE 104

Query: 71  VIGEVKKE-NFPVDINISSKMI--KIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYI 127
            + +        + INIS+K I    I +  ++   P +  SF A G     +   F Y+
Sbjct: 105 FLADTPFLKVLDLKINISAKGIVTTSIPKREILANDPIAKISFAAGGV--DKSYFWFTYV 162

Query: 128 AKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSS 187
           AK++    R CHV    D   L D +       T     +   +N+     APP+     
Sbjct: 163 AKDRRDN-RYCHVF---DGGALADDILA-----TLGQVFSLLATNNLPVKSAPPLPPNHP 213

Query: 188 LHRQSFVSNCRAPTVTE 204
              Q   +   AP + E
Sbjct: 214 SLLQGAAALAAAPKMPE 230


>UniRef50_Q8CG80 SH2 domain-containing adapter protein F n=20 Tax=Euteleostomi
           RepID=SHF_MOUSE
          Length = 238

 Score =  108 bits (269), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 29/164 (17%), Positives = 64/164 (39%), Gaps = 15/164 (9%)

Query: 154 TTAINVNTFDAQANASTSNDGFTVPAPP------MRHRSSLHRQSFVSNCRAPTVTEDVV 207
            +      F+   N  +         PP       +    L  +              + 
Sbjct: 75  ISKAFAAQFEGSENCLSPGREEKGRLPPRLSAGNPKSAKPLGMEPSSPLGEWTDPALPLE 134

Query: 208 GKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
            +VWYHG +SR DA+ LL+   E  +LVR S+ +   + LS ++++      +     ++
Sbjct: 135 NQVWYHGAISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHK 194

Query: 266 VRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                 +  FS++ E++ ++ +  + ++         ++L+ PV
Sbjct: 195 YVLGQNSPPFSSVPEIVHHYASRKLPIKGA-----EHMSLLYPV 233


>UniRef50_UPI00004D6B5A SH2B adapter protein 3 (Lymphocyte-specific adapter protein Lnk)
           (Signal transduction protein Lnk) (Lymphocyte adapter
           protein). n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI00004D6B5A
          Length = 321

 Score =  108 bits (269), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 38/234 (16%), Positives = 68/234 (29%), Gaps = 19/234 (8%)

Query: 82  VDINISSKMIKIIKQSRLIQRHPFSFFSFGAQ--GQKGTDTELMFGYIAKNKDGTDRRCH 139
           V ++I S  + +   S    +H     S          +DT      I        + C+
Sbjct: 82  VPVHIFSTQLILPNHSSFSYKHSLPINSPLCLNILTAKSDTHFYMKSICFALI-WCKSCY 140

Query: 140 VVFIEDVHKLIDVLTTAINVNTFDAQANA----------STSNDGFTVPAPPMR-HRSSL 188
            V     +     L  +  +     Q              T         P     R   
Sbjct: 141 KVGCNGPNIQTLHLFISYQLAERAQQNQPIILFNFLPTCGTYMGLPLRYFPWDHCPRPGT 200

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT-----EGDFLVRQSDHTPGKY 243
                    +       +    W+HG +SR  A  L+++      G FLVRQS+   G+Y
Sbjct: 201 GDPCLKGELKPNKTDHFLASSPWFHGPISRVKAAQLVQSQGVEGHGVFLVRQSETRRGEY 260

Query: 244 VLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
           VL+           + L    +   +   F ++ E++ Y     + +       
Sbjct: 261 VLTFNFQGRAKHLRLTLTERGQCHVQHLRFRSVLEMLQYFRLQPIPLECGAACD 314


>UniRef50_A8NNY7 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8NNY7_BRUMA
          Length = 303

 Score =  107 bits (268), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 34/126 (26%), Positives = 59/126 (46%), Gaps = 7/126 (5%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVL--S 246
            ++       + ++T+DV G  +YHG + R D + LLK EGDFL+R+++ TPG+ VL  S
Sbjct: 2   PKKEEEEAEDSVSITDDVKGADYYHGLIPRTDIEPLLKKEGDFLLRKTELTPGEIVLAIS 61

Query: 247 GRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
            R        ++  D             ++S+LI Y+ +    + +      +   L RP
Sbjct: 62  VRHNNAVRHFMVNQDQDGSFYCEHHHEKSVSDLIQYYKSTKEPLSAS-----SQARLRRP 116

Query: 307 VPCPGS 312
           +  P  
Sbjct: 117 IERPQW 122


>UniRef50_B4F705 Putative uncharacterized protein n=2 Tax=Xenopus (Silurana)
           tropicalis RepID=B4F705_XENTR
          Length = 458

 Score =  107 bits (268), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 24/111 (21%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
             +  +  + WYHG +SR DA++LL+   E  +LVR S+     + LS ++ +      +
Sbjct: 348 DPSLPLESQFWYHGAISRADAESLLRLCKEASYLVRNSETNKIDFSLSLKSIQGFMHMKL 407

Query: 259 LLDNHNRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                N+      +  F+++ E+I ++ +  + ++         ++L+ PV
Sbjct: 408 SRTKENKYVLGHNSPPFNSVPEIIHHYASQKLPIKGA-----EHMSLLYPV 453


>UniRef50_UPI0000E49A1C PREDICTED: similar to Growth factor receptor-bound protein 2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E49A1C
          Length = 176

 Score =  107 bits (267), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 27/110 (24%), Positives = 48/110 (43%), Gaps = 2/110 (1%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAENEHKH 256
            P  T   +   W+   ++R++A+ LL  E  G FLVR+S+ + G Y LS +  E+    
Sbjct: 2   GPKHTYPEIAMAWFFPTITRKNAELLLMQERNGAFLVRRSESSEGLYSLSVKYNESVQHF 61

Query: 257 LILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
            IL D   +       F ++  L+DY+    +   ++   +        P
Sbjct: 62  RILQDTAGKFHLWIVKFPSLDALVDYYRTTSVTRENQVSTQSVEQWSRNP 111


>UniRef50_C9JAB9 Putative uncharacterized protein NCK1 n=5 Tax=Eutheria
           RepID=C9JAB9_HUMAN
          Length = 174

 Score =  107 bits (267), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 51/104 (49%), Gaps = 4/104 (3%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAEN 252
           +   P++T    G  WY+G ++R  A+  L     EGDFL+R S+ +P  + +S + A+ 
Sbjct: 70  DYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLK-AQG 128

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRD 296
           ++KH  +           R FS + EL++++    +    +G  
Sbjct: 129 KNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEK 172


>UniRef50_A8WHN9 Novel protein similar to vertebrate breast cancer anti-estrogen
           resistance 3 (BCAR3) n=3 Tax=Danio rerio
           RepID=A8WHN9_DANRE
          Length = 841

 Score =  107 bits (267), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 27/111 (24%), Positives = 45/111 (40%), Gaps = 13/111 (11%)

Query: 207 VGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL------ 260
               WYHG + R+ A+ L++ +GDFL+R S  +PG YVL+ +   +     I        
Sbjct: 154 RSHAWYHGAIPRQVAENLVQRDGDFLIRDSLSSPGNYVLTCQWKNSPQHFKINKRVVAMN 213

Query: 261 --DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
              +  +       F +I  L+ Y+V N   V              +P+  
Sbjct: 214 EAYSRVQYLFEKEGFDSIPALVRYYVGNREPVSEVIGAIIF-----QPINR 259


>UniRef50_B3XVY9 Protein tyrosine kinase tec n=1 Tax=Monosiga ovata
           RepID=B3XVY9_9EUKA
          Length = 680

 Score =  107 bits (267), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 34/120 (28%), Positives = 52/120 (43%), Gaps = 6/120 (5%)

Query: 186 SSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGK 242
           S        SN         +  + W+HG +SR +A ALL   K EG FLVR+S+   G+
Sbjct: 280 SQGRVGYIPSNYVR---QAGIESEAWFHGRISRAEAAALLHVAKQEGCFLVRESESKVGE 336

Query: 243 YVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLN 302
           Y LS    ++   + I  +           F +I +LI+YH  N   + +  R     L+
Sbjct: 337 YSLSVSHGDSLRHYHIKKEGEEFYINDRHRFPDICKLIEYHKLNSGGLVTRLRKSIADLH 396


>UniRef50_Q7K137 Lnk, isoform A n=13 Tax=Drosophila RepID=Q7K137_DROME
          Length = 723

 Score =  107 bits (267), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 34/154 (22%), Positives = 61/154 (39%), Gaps = 15/154 (9%)

Query: 167 NASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTED----------VVGKVWYHGNL 216
           N   ++     P  P+R      R S  SN      TE+          +    W+HG L
Sbjct: 388 NELGTSPTSGPPDIPVRPHRGEQRLSASSNFDGIEGTENDADVADLTAEMSVFPWFHGTL 447

Query: 217 SREDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDR 271
           +R +A  ++        G FLVRQS+   G++VL+           + +    + R +  
Sbjct: 448 TRSEAARMVLHSDAAGHGYFLVRQSETRRGEFVLTFNFQGRAKHLRLTISEKGQCRVQHL 507

Query: 272 TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
            F +I E++++  +N + + S G    T    + 
Sbjct: 508 WFPSIQEMLEHFRHNPIPLESGGTSDVTLTEWVH 541


>UniRef50_UPI00017F07B9 PREDICTED: similar to Tyrosine-protein kinase Lyn n=2
           Tax=Euteleostomi RepID=UPI00017F07B9
          Length = 580

 Score =  107 bits (266), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 30/185 (16%), Positives = 62/185 (33%), Gaps = 10/185 (5%)

Query: 112 AQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTS 171
           +       +      +        +     + E+   ++  L     ++  D        
Sbjct: 78  SGTSLPPVSCGFLACLQIAYGNNAKGLDNHYPEEQGDIVVALYPYDGIHPDDLSFKKGEK 137

Query: 172 NDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KT 227
                      + +S   ++              +  + W+  +++R+DA+  L     +
Sbjct: 138 MKVLEEHGEWWKAKSLSTKREGFIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNS 197

Query: 228 EGDFLVRQSDHTPGKYVLSGR----TAENEHKHLILL--DNHNRVRTRDRTFSNISELID 281
            G FL+R+S+   G Y LS R       +  KH  +   DN     +   TF  IS++I 
Sbjct: 198 PGAFLIRESETLKGSYSLSVRDYDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIK 257

Query: 282 YHVNN 286
           Y+  N
Sbjct: 258 YYQTN 262


>UniRef50_A9VAA5 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9VAA5_MONBE
          Length = 746

 Score =  107 bits (266), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 35/203 (17%), Positives = 65/203 (32%), Gaps = 20/203 (9%)

Query: 115 QKGTDTELMFGYIAKNKDGTDRRCHVV-FIEDVHKLIDVLTTAINVNTFDAQANASTSND 173
           +     E  F  +  +K  +  R       E    +               + +      
Sbjct: 246 ENPDPLEGWFALLDADKGKSGYRKFEPDTSEGKVVVALYDNDPRGDMELSMRKDDYLLEL 305

Query: 174 GFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEG 229
                    RH  +           AP   + +  + W+ G ++R  A+ LL    +  G
Sbjct: 306 RSDGAWVQCRHLMTNEEGFVPGTFVAP--YKSLEAEPWFFGPITRAKAEKLLGVPARKHG 363

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD---RTFSNISELIDYHVNN 286
            FL+R+S+ TPG + LS +  EN  +H  +      ++ +        ++  LI YH  +
Sbjct: 364 CFLIRESESTPGTFSLSMKDGENV-RHFRVKKVAGGIKLQGSPSSPHKDLPSLIKYHKRH 422

Query: 287 GMAVRSEGRDRETSLNLIRPVPC 309
              +            L  P P 
Sbjct: 423 RGGLT---------TTLKVPCPR 436


>UniRef50_Q13882 Protein-tyrosine kinase 6 n=12 Tax=Mammalia RepID=PTK6_HUMAN
          Length = 451

 Score =  107 bits (266), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 36/141 (25%), Positives = 56/141 (39%), Gaps = 10/141 (7%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG----DFLVRQS 236
                 ++ +     N  A    E V  + W+ G +SR +A   L+ EG     FL+R S
Sbjct: 50  LDEAGGAVAQGYVPHNYLA--ERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVS 107

Query: 237 DHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGR 295
           +     YVLS R  +    + I      R+   +  +F ++ EL++YH    +   S G 
Sbjct: 108 EKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSL---SHGL 164

Query: 296 DRETSLNLIRPVPCPGSDDIE 316
                     P P P  DD E
Sbjct: 165 RLAAPCRKHEPEPLPHWDDWE 185


>UniRef50_D1H0Y7 Abl kinase 1 n=1 Tax=Schistosoma mansoni RepID=D1H0Y7_SCHMA
          Length = 1663

 Score =  107 bits (266), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 36/225 (16%), Positives = 72/225 (32%), Gaps = 23/225 (10%)

Query: 93  IIKQSRLI---QRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKL 149
            ++    +     + F+ +         +       + +           ++  E   K 
Sbjct: 128 TMETGNSVNTSCNYLFNNYR--RGWVPTSYLATANVFQSSAPSKQSYPQQLIGCEGSEKP 185

Query: 150 IDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGK 209
              +      N+    AN +  +    V      H   +          +          
Sbjct: 186 NCSVNAPCLSNSQSIIANDNMQSRVQNVSNKGPVHHVMMDSSPLSLLEPSLLPY------ 239

Query: 210 VWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN-RV 266
            WYHG +SR+  + LL++   G FLVR S+  PG+  ++ R     + + I  D+     
Sbjct: 240 SWYHGAVSRQAGEHLLRSGITGSFLVRASESAPGQLSVTVRHLGRVYHYRISQDSRGLFY 299

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
            T    F  + +LI++H  +   +            L+  VP P 
Sbjct: 300 ITEAHRFPTVVQLIEHHSRSADGLV---------CPLLYSVPKPQ 335


>UniRef50_O43639 Cytoplasmic protein NCK2 n=72 Tax=Euteleostomi RepID=NCK2_HUMAN
          Length = 380

 Score =  107 bits (266), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 28/119 (23%), Positives = 52/119 (43%), Gaps = 4/119 (3%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVL 245
              +   +   P+ +    G+ WY+GN++R  A+  L     EGDFL+R S+ +P  + +
Sbjct: 263 PAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSV 322

Query: 246 SGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
           S + A  ++KH  +    N      R F  + EL++++    +     G        L 
Sbjct: 323 SLK-ASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYKKAPIFTSEHGEKLYLVRALQ 380


>UniRef50_B0WDQ7 Putative uncharacterized protein n=2 Tax=Culicini RepID=B0WDQ7_CULQU
          Length = 1081

 Score =  107 bits (266), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 38/151 (25%), Positives = 65/151 (43%), Gaps = 14/151 (9%)

Query: 166  ANASTSNDGFTVPAPPMRHRSSLHRQ----SFVSNCRAPTVTEDVVGKVWYHGNLSREDA 221
               S + +     A P++   +L       +  SN      +  +  + WYHG++SR DA
Sbjct: 931  FKQSLTLNLNECSAKPVKKFGTLDFGLNFNTARSNVDLIDASISLDRQGWYHGSISRIDA 990

Query: 222  QALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH-NRVRTRD--RTFSNI 276
            + +L+   EG FLVR S+ T   Y L+ ++A+      I  D   ++       R F  I
Sbjct: 991  EKILRPLGEGSFLVRNSESTRQDYSLTLKSAKGFMHMRIQRDPDSSQYILGQFSRPFPTI 1050

Query: 277  SELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             ++I +   N + VR         + L+ PV
Sbjct: 1051 PDMIRHFCLNRLPVRGA-----EHMCLLEPV 1076


>UniRef50_UPI000194DE57 PREDICTED: similar to predicted protein n=1 Tax=Taeniopygia guttata
           RepID=UPI000194DE57
          Length = 699

 Score =  106 bits (265), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 41/200 (20%), Positives = 75/200 (37%), Gaps = 11/200 (5%)

Query: 99  LIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAIN 158
                 F+     + G +   + ++      + +    RC     +    ++D     + 
Sbjct: 472 PGADDKFNSTRKQSAGAQFRHSLMVLMERMYSANPHFVRCIKPNNQKEPGVLDNQVVLLQ 531

Query: 159 VNTFDAQANASTS------NDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWY 212
              FD   N S         +     A   + +     + F        + +D     W 
Sbjct: 532 STPFDNFLNPSVPPPVLGTEEQTGEEAKVRKLKRGATLRWFTETQAQKVMQDDGAFPSWL 591

Query: 213 HGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT-- 268
           HG +SR +A+ LL  K  G FLVR S   PG Y+L+ R       ++I +  + R     
Sbjct: 592 HGMISRREAENLLIDKPLGSFLVRISQSRPG-YILTYRGEGRCRHYMIQVQPNARYVILG 650

Query: 269 RDRTFSNISELIDYHVNNGM 288
            DR  ++++EL+ YH + G+
Sbjct: 651 EDRAHASLTELVRYHQSVGI 670


>UniRef50_A9UZG2 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UZG2_MONBE
          Length = 1021

 Score =  106 bits (265), Expect = 9e-22,   Method: Composition-based stats.
 Identities = 36/185 (19%), Positives = 76/185 (41%), Gaps = 22/185 (11%)

Query: 125 GYIAKNKDGTDRRCHVVFIEDVHKLIDVL--------TTAINVNTFDAQANAS---TSND 173
           G++A+      +R   +++++     + +            + +  D + +AS       
Sbjct: 724 GFLARKFRANMKRKMQMYLQETGVFFETVRRNGATYGARVASNDAEDMRRHASGIQPRRP 783

Query: 174 GFTVPAPPMRHRSSLHRQSFV------SNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT 227
             +VPA P +    L R + +         R            W+HG +SR +A+ LL+ 
Sbjct: 784 PPSVPAGPRKSEQELKRDASIAWWKEKEEPRGAGKDSYGGFMPWFHGLISRREAEELLRP 843

Query: 228 E--GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD--RTFSNISELIDYH 283
              G FLVR S++  G Y LS R ++    +++  +   +       +   +++ELI++ 
Sbjct: 844 RYIGCFLVRVSENRFG-YTLSYRVSDRCRHYMVEQNTQGQYALVGVSKIADSLNELIEWF 902

Query: 284 VNNGM 288
             N +
Sbjct: 903 QRNPI 907


>UniRef50_A8P596 SH2 domain containing protein n=1 Tax=Brugia malayi
           RepID=A8P596_BRUMA
          Length = 119

 Score =  106 bits (265), Expect = 9e-22,   Method: Composition-based stats.
 Identities = 40/104 (38%), Positives = 60/104 (57%), Gaps = 4/104 (3%)

Query: 206 VVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
           +  + WYHG + R  A+++L+ EGDFLVR S +T   +VLSG         L+L +N  +
Sbjct: 12  LDRQPWYHGEMERATAESMLRNEGDFLVRISPNTANNFVLSGIANSVARHFLLLDENDQK 71

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           VR + + F  I ELI+YH    + + SEG    + L+LIRP+  
Sbjct: 72  VRKQQQVFETIVELIEYHRGENVPIISEG----SELHLIRPIVR 111


>UniRef50_Q96IW2 SH2 domain-containing adapter protein D n=4 Tax=Euteleostomi
           RepID=SHD_HUMAN
          Length = 340

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 29/107 (27%), Positives = 51/107 (47%), Gaps = 9/107 (8%)

Query: 205 DVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
            +  + W+HG L+R DA++LL    EG +LVR S+  P    LS R+++           
Sbjct: 234 PLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSLSLRSSQGFLHLKFARTR 293

Query: 263 HNRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
            N+V     +  F ++ EL+ ++ +  + V+         L L+ PV
Sbjct: 294 ENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGA-----EHLALLYPV 335


>UniRef50_A2BDR6 SH2 domain containing 3C n=4 Tax=Danio rerio RepID=A2BDR6_DANRE
          Length = 635

 Score =  106 bits (264), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 32/138 (23%), Positives = 61/138 (44%), Gaps = 20/138 (14%)

Query: 180 PPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHT 239
           PP + +  L ++  +S+C       ++    WYHG +  E +++L++ EGDFL+R S  +
Sbjct: 26  PPDKLKQELEKELKLSSC-------NLSSHGWYHGRIPWEVSESLVQQEGDFLIRDSLSS 78

Query: 240 PGKYVLSGRTAENEHKHLILL--------DNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
            G YVL+ R  +     LI              +    + TF ++  L+  +V N   + 
Sbjct: 79  IGDYVLTCRWNQKALHFLITKVLLRSYDTYTRVQYILEEETFYSVPALVHSYVGNKRPLT 138

Query: 292 SEGRDRETSLNLIRPVPC 309
                 +++  +  PV  
Sbjct: 139 K-----KSAAYIYSPVNR 151


>UniRef50_UPI000180C238 PREDICTED: similar to v-crk sarcoma virus CT10 oncogene homolog
           (avian)-like n=1 Tax=Ciona intestinalis
           RepID=UPI000180C238
          Length = 295

 Score =  106 bits (264), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 34/105 (32%), Positives = 54/105 (51%), Gaps = 13/105 (12%)

Query: 208 GKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
              WY G +SR+D+Q  L  +  G FLVR S   PG YVLS  +  ++  H I+    NR
Sbjct: 11  EDSWYFGMVSRKDSQNKLLHQKHGSFLVRDSTTCPGDYVLSV-SENSKVSHYIINKQENR 69

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
           ++  D+ F ++ EL+D++  + +           +  LI P+P P
Sbjct: 70  LKIGDQMFDSMPELLDFYKVHYL----------DTTTLIEPIPKP 104


>UniRef50_Q15464 SH2 domain-containing adapter protein B n=17 Tax=Euteleostomi
           RepID=SHB_HUMAN
          Length = 509

 Score =  106 bits (264), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 37/183 (20%), Positives = 64/183 (34%), Gaps = 24/183 (13%)

Query: 144 EDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVT 203
           +D  +  D        N     A A+  N      + P   R    +         P   
Sbjct: 327 QDDDRPADEYDQPWEWNRVTIPALAAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKH 386

Query: 204 ----------------EDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVL 245
                             +  ++WYHG +SR DA+ LL+   E  +LVR S  +   Y L
Sbjct: 387 GSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSL 446

Query: 246 SGRTAENEHKHLILLDNHNRVRTRD-RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
           S R+ +      +       V  ++   F ++ E+I Y+    + ++         L+L+
Sbjct: 447 SLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPEVIHYYTTRKLPIKGA-----EHLSLL 501

Query: 305 RPV 307
            PV
Sbjct: 502 YPV 504


>UniRef50_UPI000180BBDB PREDICTED: similar to ABL1 n=1 Tax=Ciona intestinalis
           RepID=UPI000180BBDB
          Length = 1063

 Score =  106 bits (264), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 27/103 (26%), Positives = 43/103 (41%), Gaps = 5/103 (4%)

Query: 191 QSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGR 248
               SN   P  +  +    WYHG +SR  A+ LL +   G FLVR S+   G   +S R
Sbjct: 69  GWVPSNYITPATS--LNMHTWYHGAVSRAAAEYLLSSGINGSFLVRDSESCRGHLSVSVR 126

Query: 249 TAENEHKHLILLDNHNRVRTR-DRTFSNISELIDYHVNNGMAV 290
              + + + I +D         +  F  + EL+ +H      +
Sbjct: 127 FNASVYHYRINVDTAGLFYISPEHRFQTLPELVHHHSYASDGL 169


>UniRef50_Q7QAK4 AGAP003651-PA n=5 Tax=Culicidae RepID=Q7QAK4_ANOGA
          Length = 1315

 Score =  106 bits (264), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 32/115 (27%), Positives = 49/115 (42%), Gaps = 9/115 (7%)

Query: 201  TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP-GKYVLSGRTAENEHKHLIL 259
            +    +  + W+HG L RE+   LL+ EGDFLVR++      + VLS       HKH I+
Sbjct: 941  STNRPLHEEEWFHGVLPREEVVRLLRNEGDFLVRETTRNDESQTVLSVCWNG--HKHFIV 998

Query: 260  LDN-HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
                    R     F +I ELI +   + + V        +   L +PV     +
Sbjct: 999  QTTAEGHYRFEGPAFPSIQELIVHQYQSELPVTGR-----SGAVLRKPVLRERWE 1048


>UniRef50_UPI0001A2CA18 UPI0001A2CA18 related cluster n=2 Tax=Clupeocephala
           RepID=UPI0001A2CA18
          Length = 257

 Score =  106 bits (263), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 36/192 (18%), Positives = 64/192 (33%), Gaps = 29/192 (15%)

Query: 141 VFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPP---MRHRSSLHRQSFVSNC 197
                   L+  +      ++ D                P         +  R     N 
Sbjct: 49  PSSPLPENLVVAIYKYDPAHSDDLGFEKGEKMKILDCDDPEWYMAESLFTGQRGYIPKNF 108

Query: 198 RAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRT---- 249
            A   +  +  + W++ NLSR DA   L     T+G FL+R+S+  PG + +S R     
Sbjct: 109 VAKLNS--METEPWFYKNLSRNDAMRQLLAPGNTQGSFLIRESETQPGSFSISVRDLDPM 166

Query: 250 AENEHKHLILL--DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             +  KH  +   D      T   +F+++SEL+ ++      +            L++P 
Sbjct: 167 QGDIIKHYRIRNMDAGGFYITNKISFNSLSELVKHYSREADGLC---------TRLVKPC 217

Query: 308 -----PCPGSDD 314
                  P   D
Sbjct: 218 QTRAPQKPWWQD 229


>UniRef50_Q6NP28 LP09923p (Fragment) n=26 Tax=Coelomata RepID=Q6NP28_DROME
          Length = 847

 Score =  106 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 35/224 (15%), Positives = 75/224 (33%), Gaps = 13/224 (5%)

Query: 88  SKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVH 147
           S  +   +             S    G +   + ++     +    +     V       
Sbjct: 358 SSSLNAAQMGMHGAERALPPKSLALSGSQHG-SNMLLHTAPQPPQASQPAAVVGVSGSGS 416

Query: 148 KLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVV 207
             +     + ++N   A +  + S+   +     M H S           R+      + 
Sbjct: 417 AGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRS-RCEVKLN 475

Query: 208 GKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
              W+HG+++R++A+ LL+   +G FLVR+S + PG Y L          + +    +  
Sbjct: 476 AMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKL 535

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
               +  F N+ +L+ ++         E         LI+ +P 
Sbjct: 536 TIDDEEYFENLGQLVAHY---------EADADGLCTQLIKCLPK 570


>UniRef50_B4GU33 GL25360 n=1 Tax=Drosophila persimilis RepID=B4GU33_DROPE
          Length = 1444

 Score =  106 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 37/175 (21%), Positives = 61/175 (34%), Gaps = 14/175 (8%)

Query: 142  FIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPT 201
             + +  KL   L TA+         N                  S+      +       
Sbjct: 1270 SMREDQKLASKLDTALFRQNLTLNLNEPRQATKQFGSLDLRGLNSTKELNMNLCQGYVTA 1329

Query: 202  V-----TEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEH 254
            V     +  +  + WYHG ++R +A+  L+   EG FLVR  + T   Y LS + A+   
Sbjct: 1330 VDLIDVSIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFM 1389

Query: 255  KHLILLDNHNRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
               I  +   +       R F  + ++I +   N + VR         + LI PV
Sbjct: 1390 HMRIQRNETGQYILGQFSRPFDTVPDMIRHFCLNRLPVRGA-----EHMCLIEPV 1439


>UniRef50_UPI0000E478D2 PREDICTED: similar to SH2/SH3 adaptor Grb2 n=1
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E478D2
          Length = 241

 Score =  106 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 29/138 (21%), Positives = 54/138 (39%), Gaps = 10/138 (7%)

Query: 179 APPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQ 235
              +       +     N      +       WY G +SR+ A+  L +   +G F++R 
Sbjct: 35  RHWLLAHQGAKQGLVPENYLKIEKS-----HPWYVGKISRKVAEEYLMSMPSDGAFMIRD 89

Query: 236 SDHTP--GKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           S+  P  G + LS +  +      IL D   +       F++I++L+DYH +N ++   E
Sbjct: 90  SESNPDSGNFSLSVKFRDQVQHFKILTDLAGKYFLWVVKFTSINDLVDYHKDNSVSRTQE 149

Query: 294 GRDRETSLNLIRPVPCPG 311
               E  + +      P 
Sbjct: 150 IVLNEPCVPIEDANQRPQ 167


>UniRef50_UPI0000D9EE2E PREDICTED: similar to src homology 2 domain-containing transforming
           protein D n=1 Tax=Macaca mulatta RepID=UPI0000D9EE2E
          Length = 221

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 34/154 (22%), Positives = 62/154 (40%), Gaps = 10/154 (6%)

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS 217
              +   Q           +P P     + +   +  +N    T+        W+HG L+
Sbjct: 69  CHPSLGLQEKRGPRCVNLGLPEPVSLSGNGMTPPTRSTNTPGDTLC-CCPIYGWFHGPLN 127

Query: 218 REDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--F 273
           R DA++LL    EG +LVR S+ +P    LS R+++            N+V     +  F
Sbjct: 128 RADAESLLSLCKEGSYLVRLSETSPQDCSLSLRSSQGFLHLKFARTRENQVVLGQHSGPF 187

Query: 274 SNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
            ++ EL+ ++ +  + V+         L L+ PV
Sbjct: 188 PSVPELVLHYSSRPLPVQGA-----EHLALLYPV 216


>UniRef50_UPI000192756A PREDICTED: similar to predicted protein n=2 Tax=Hydra
           magnipapillata RepID=UPI000192756A
          Length = 295

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 27/109 (24%), Positives = 59/109 (54%), Gaps = 6/109 (5%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
           + + +    WYHG+++R   +++L  +  G FLVR S    G YVLS  +  N+  H I+
Sbjct: 1   MADRLFMYSWYHGDITRPACESILMAQKPGLFLVRDSSTCKGGYVLSV-SENNKVSHYII 59

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
            + +++ +  D+TF+++ E+++++  + +         E++  +  P P
Sbjct: 60  TNKNSQYQIGDQTFNDLPEIVEFYKRHFLDTT---TLVESAPRVTEPTP 105


>UniRef50_Q9VPU1 Dreadlocks, isoform B n=11 Tax=Neoptera RepID=Q9VPU1_DROME
          Length = 548

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 31/128 (24%), Positives = 57/128 (44%), Gaps = 8/128 (6%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPG 241
           R +   +    +   P    ++ GK WY+G ++R     +L     +GDFL+R S+   G
Sbjct: 422 RRNEGNKPAAQSSGQPIERPNLAGKSWYYGAITRSQCDTVLNGHGHDGDFLIRDSETNMG 481

Query: 242 KYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSL 301
            Y +S + A   +KH  +    N      R F ++ +L+D++    +    +G      L
Sbjct: 482 DYSVSLK-APGRNKHFRVHVEQNMYCIGQRKFHSLDQLVDHYQRAPIYTNKQG----EKL 536

Query: 302 NLIRPVPC 309
            L+R +P 
Sbjct: 537 YLVRSLPK 544


>UniRef50_O75815 Breast cancer anti-estrogen resistance protein 3 n=43
           Tax=Euteleostomi RepID=BCAR3_HUMAN
          Length = 825

 Score =  105 bits (262), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 26/132 (19%), Positives = 55/132 (41%), Gaps = 13/132 (9%)

Query: 186 SSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVL 245
            +  +            +ED+    WYHG + R+ ++ L++ +GDFLVR S  +PG +VL
Sbjct: 129 RTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVL 188

Query: 246 SGRTAENEHKHLILLD--------NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
           + +         I           +  + +    +F +I  L+  +V N   +      +
Sbjct: 189 TCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPIS-----Q 243

Query: 298 ETSLNLIRPVPC 309
           ++   + +P+  
Sbjct: 244 QSGAIIFQPINR 255


>UniRef50_Q9BRG2 SH2 domain-containing protein 3A n=12 Tax=Eutheria
           RepID=SH23A_HUMAN
          Length = 576

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 35/126 (27%), Positives = 54/126 (42%), Gaps = 9/126 (7%)

Query: 198 RAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHL 257
           + P   ED+ G+ WYHG LSR+ A+ALL+  GDFLVR S    G  V+S R   +     
Sbjct: 2   QVPQDGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFE 61

Query: 258 I----LLDNHNR----VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET-SLNLIRPVP 308
           +    L     R     +  D  F +I  L+  ++     +        +  +    P+ 
Sbjct: 62  VFRVALRPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLR 121

Query: 309 CPGSDD 314
              S+D
Sbjct: 122 RSFSED 127


>UniRef50_UPI0000E20474 PREDICTED: TXK tyrosine kinase n=1 Tax=Pan troglodytes
           RepID=UPI0000E20474
          Length = 461

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 44/217 (20%), Positives = 70/217 (32%), Gaps = 26/217 (11%)

Query: 102 RHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNT 161
           +H   + S     Q     +   G +  +K           + +    +  L   +    
Sbjct: 44  QHRRPWLS-----QLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREP 98

Query: 162 FDAQANASTSNDGFTVPAP-PMRHRSSLH-RQSFVSNCRAPTVTEDVVGKVWYHGNLSRE 219
            +     +          P   + R  L       SN        ++    WYH N++R 
Sbjct: 99  CNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRN 158

Query: 220 DAQALLK---TEGDFLVRQSDHTPGKYVLSG----RTAENEHKHLILLDNHN--RVRTRD 270
            A+ LL+    EG F+VR S    G Y +S     R+ E   KH  +  N +        
Sbjct: 159 QAEHLLRQESKEGAFIVRDS-RHLGSYTISVFMGARSTEAAIKHYQIKKNDSGQWYVAER 217

Query: 271 RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             F +I ELI YH +N   +            L  PV
Sbjct: 218 HAFQSIPELIWYHQHNAAGLM---------TRLRYPV 245


>UniRef50_C4Q974 Growth factor receptor-bound protein, putative n=2 Tax=Schistosoma
           RepID=C4Q974_SCHMA
          Length = 317

 Score =  105 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 28/153 (18%), Positives = 56/153 (36%), Gaps = 17/153 (11%)

Query: 147 HKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDV 206
             + +   T    +    +  ++    G        + R         +N  +      +
Sbjct: 2   EAVANYPFTPTEPDELGFEKGSTLYIVGMEEDPNWYKARLGNQEGMVPANYIS------L 55

Query: 207 VGKVWYHGNLSREDAQALL-----------KTEGDFLVRQSDHTPGKYVLSGRTAENEHK 255
               WY    SR +A+A L           + +G F++RQS++ PG++ +S +   +   
Sbjct: 56  YPHPWYIPRCSRREAEARLLETDPDTNRDVQPDGAFILRQSENDPGQFSISVKEGSSVLH 115

Query: 256 HLILLDNHNRVRTRDRTFSNISELIDYHVNNGM 288
             I  D   +       F +I+ LIDYH +  +
Sbjct: 116 FRIFFDPKGKYYIWTNKFDSINALIDYHRHQTI 148


>UniRef50_P06241 Tyrosine-protein kinase Fyn n=119 Tax=root RepID=FYN_HUMAN
          Length = 537

 Score =  105 bits (261), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 34/139 (24%), Positives = 52/139 (37%), Gaps = 21/139 (15%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQS 236
             R  ++       SN  AP   + +  + WY G L R+DA+  L       G FL+R+S
Sbjct: 121 EARSLTTGETGYIPSNYVAPV--DSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRES 178

Query: 237 DHTPGKYVLSGRT----AENEHKHLILL--DNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           + T G Y LS R       +  KH  +   DN     T    F  + +L+ ++       
Sbjct: 179 ETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSE----- 233

Query: 291 RSEGRDRETSLNLIRPVPC 309
               R       L+ P   
Sbjct: 234 ----RAAGLCCRLVVPCHK 248


>UniRef50_C5J914 Protein tyrosine phosphatase n11 (Shp2), putative n=1
           Tax=Schistosoma mansoni RepID=C5J914_SCHMA
          Length = 708

 Score =  105 bits (261), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 35/122 (28%), Positives = 60/122 (49%), Gaps = 9/122 (7%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVL 245
            +   +   + P ++ED   + W+HG ++ ++A+ +L   G    FLVR+S H PG YVL
Sbjct: 92  EKNGDLIELKYPLISEDPTTERWFHGKITGKEAEKMLLERGKPDCFLVRESVHRPGSYVL 151

Query: 246 SGRTAENEHKHLILLDNHNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
           S  T E     +I    +          FS++ ELID++ N  M  ++ G      ++L 
Sbjct: 152 SVLTGEQVAHIMIHGKPNGMYDVGGGHQFSSLKELIDFYTNTPMVEKNGGL-----VSLK 206

Query: 305 RP 306
           +P
Sbjct: 207 QP 208



 Score = 86.0 bits (211), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 29/111 (26%), Positives = 46/111 (41%), Gaps = 8/111 (7%)

Query: 210 VWYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
            W+H NL+  +A+ LL  +G    FL R S  TPG + LS R  +      I        
Sbjct: 7   RWFHHNLTGLEAEKLLTLKGVSGSFLARPSHSTPGSFTLSVRRGDEVTHIRIQNTEEFLD 66

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC--PGSDDI 315
                 F+ +SEL+ Y++ N   +R         + L  P+    P ++  
Sbjct: 67  LYGGEKFATLSELVTYYMENEGQLR---EKNGDLIELKYPLISEDPTTERW 114


>UniRef50_B5DKY0 GA22752 n=6 Tax=Drosophila RepID=B5DKY0_DROPS
          Length = 1495

 Score =  105 bits (261), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 37/175 (21%), Positives = 61/175 (34%), Gaps = 14/175 (8%)

Query: 142  FIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPT 201
             + +  KL   L TA+         N                  S+      +       
Sbjct: 1321 SMREDQKLASKLDTALFRQNLTLNLNEPRQATKQFGSLDLRGLNSTKELNMNLCQGYVTA 1380

Query: 202  V-----TEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEH 254
            V     +  +  + WYHG ++R +A+  L+   EG FLVR  + T   Y LS + A+   
Sbjct: 1381 VDLIDVSIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNCESTKQDYSLSLKGAKGFM 1440

Query: 255  KHLILLDNHNRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
               I  +   +       R F  + ++I +   N + VR         + LI PV
Sbjct: 1441 HMRIQRNETGQYILGQFSRPFDTVPDMIRHFCLNRLPVRGA-----EHMCLIEPV 1490


>UniRef50_Q9UQQ2 SH2B adapter protein 3 n=22 Tax=Euteleostomi RepID=SH2B3_HUMAN
          Length = 575

 Score =  105 bits (261), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 40/309 (12%), Positives = 91/309 (29%), Gaps = 61/309 (19%)

Query: 35  VMVSEMRVQVVSECIQHVAATVG-------VTAAREINPVVSRVIGEVKKENFPVDINIS 87
            M S  R Q     ++      G           +   P +      +++  +   + + 
Sbjct: 210 SMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMP 269

Query: 88  SKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVH 147
             +   + +   ++      F  G + Q  +    +     +  + T+   H+       
Sbjct: 270 DNLYTFVLK---VKDRTDIIFEVGDEQQLNSWMAELSECTGRGLESTEAEMHI------- 319

Query: 148 KLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP---TVTE 204
                                  S    +  + P     SL++ +       P       
Sbjct: 320 ----------------------PSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDH 357

Query: 205 DVVGKVWYHGNLSREDAQALLK-----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
            +    W+HG +SR  A  L++       G FLVRQS+   G+YVL+           + 
Sbjct: 358 FLSCYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLS 417

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE--------------GRDRETSLNLIR 305
           L    + R +   F ++ +++ +   + + +                  +   +   ++ 
Sbjct: 418 LTERGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLF 477

Query: 306 PVPCPGSDD 314
           P   P  D 
Sbjct: 478 PFSLPHWDS 486


>UniRef50_UPI0000E45D4F PREDICTED: similar to SH2 domain containing 4B n=2
           Tax=Deuterostomia RepID=UPI0000E45D4F
          Length = 470

 Score =  105 bits (261), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 40/204 (19%), Positives = 76/204 (37%), Gaps = 18/204 (8%)

Query: 125 GYIAKNKDGTDRRCHVVF-----IEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPA 179
            + AK      RR  ++      +    +LI +    +       +   S        P 
Sbjct: 261 SHRAKIAREEVRRSRILSKDLTHLTIQEELIVMDKRIVPPEKPLEEEKPSLPLRKRQAPR 320

Query: 180 PPMRHRSSLHRQSF---VSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVR 234
           PP         + F       +A  + +      W+HG ++R+ A+ LL  K EG FLVR
Sbjct: 321 PPKPTGHKSVVEWFQKEECERQAGLLKDTKEIAPWFHGIITRQQAEYLLFPKAEGHFLVR 380

Query: 235 QSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT---RDRTFSNISELIDYHVNNGMAVR 291
            S+   G Y LS R  E   KH ++  + +         +  +++ +L+ +H+   +   
Sbjct: 381 VSNRIWG-YALSFRDKER-AKHFLIDASGSMYSFFGQDQKDHASLEDLVQFHMRMPI--- 435

Query: 292 SEGRDRETSLNLIRPVPCPGSDDI 315
           SE          ++    P  +++
Sbjct: 436 SEMGKEVLKTPCVQAANPPDYEEL 459


>UniRef50_B7QIL2 Dreadlocks/dock, putative (Fragment) n=1 Tax=Ixodes scapularis
           RepID=B7QIL2_IXOSC
          Length = 372

 Score =  105 bits (261), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 27/116 (23%), Positives = 50/116 (43%), Gaps = 8/116 (6%)

Query: 198 RAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEH 254
           + P    ++  K WY G++ R     +L     +GDFL+R S+   G   +S + A   +
Sbjct: 262 QQPRGRPELRAKEWYFGSIPRSQCDQVLNECAQDGDFLIRDSETNVGDLSVSLK-APLRN 320

Query: 255 KHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
           KH  +           R FS + +L++++    +    +G      + L+RP   P
Sbjct: 321 KHFRVHVEDGVFCIGQRRFSQLDDLVEHYKRAPIYTSPKGD----KMFLVRPFKRP 372


>UniRef50_P42686 Tyrosine-protein kinase isoform SRK1 n=4 Tax=Metazoa
           RepID=SRK1_SPOLA
          Length = 505

 Score =  104 bits (260), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 28/147 (19%), Positives = 53/147 (36%), Gaps = 27/147 (18%)

Query: 186 SSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE----GDFLVRQSDHTPG 241
           ++       SN  A    + +  + W+ G + R +A+ +L       G FL+R S+ TPG
Sbjct: 99  TAGKEGYIPSNYVA--EYKSLDAEEWFLGKIKRVEAEKMLNQSFNQVGSFLIRDSETTPG 156

Query: 242 KYVLSGRTAENEHKHLILLDNHN-RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETS 300
            + LS +  +    + +          TR  TF  + EL+D++                 
Sbjct: 157 DFSLSVKDQDRVRHYRVRRLEDGSLFVTRRSTFQILHELVDHYK---------IETDGLC 207

Query: 301 LNLIRPV-----------PCPGSDDIE 316
             L+ P                +++ E
Sbjct: 208 CKLLYPCLQAEKPQTAGLLRQANEEWE 234


>UniRef50_D2GVU7 Putative uncharacterized protein (Fragment) n=1 Tax=Ailuropoda
           melanoleuca RepID=D2GVU7_AILME
          Length = 574

 Score =  104 bits (260), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 29/152 (19%), Positives = 54/152 (35%), Gaps = 8/152 (5%)

Query: 168 ASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP---TVTEDVVGKVWYHGNLSREDAQAL 224
            S    G      P     SL++ +       P        +    W+HG +SR  A  L
Sbjct: 325 PSALEPGTGTSNSPGGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQL 384

Query: 225 LK-----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISEL 279
           ++       G FLVRQS+   G+YVL+           + L    + R +   F ++ ++
Sbjct: 385 VQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVDM 444

Query: 280 IDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
           + +   + + +           + +  V  P 
Sbjct: 445 LHHFQRSPIPLECGAACDVRLSSYVVVVSQPP 476


>UniRef50_Q7QE10 AGAP010710-PA (Fragment) n=2 Tax=Culicidae RepID=Q7QE10_ANOGA
          Length = 952

 Score =  104 bits (260), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 43/321 (13%), Positives = 81/321 (25%), Gaps = 57/321 (17%)

Query: 36  MVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVI----GEVKKENFPVDINISSKM- 90
              ++R    +  +         T   E+     R I     + +       ++   K+ 
Sbjct: 106 PPHDVRSHGTTNLLHRATKESNYTVVSELLKCGYRNIDSKNQDGQTAVHLACLHADDKIL 165

Query: 91  IKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLI 150
           +K+I++   I        +         +   M   + K       R        +H+  
Sbjct: 166 LKLIERGANINSRDAKGNTPLHYACAKRNGLEMVRMLIKAAASLQARNSETGWVPLHEAA 225

Query: 151 DVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKV 210
           D             +       +   +P+   R R       F++              +
Sbjct: 226 DNGNIEAIQELLSHRVPHRPRTNFGEMPSDLARLRGHYQVVEFLNAYEP--QRPLTHRDL 283

Query: 211 WYHGNLSREDAQALLK------------------TE-------------------GDFLV 233
           WYHG L R  A   LK                   +                   G +LV
Sbjct: 284 WYHGTLERTAAVDYLKDFAVKLLPNLAHRQQQQQPDRDGNKENGECLDGLEQSTSGTYLV 343

Query: 234 RQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
           R S       VL+          +I               +++  LI+++      +   
Sbjct: 344 RYSAKQNVD-VLTMLYDNEPKHFIIQRQQDWLYIDEGPYMNSLEHLIEHYTRFSDGL--- 399

Query: 294 GRDRETSLNLIRPV---PCPG 311
                  +NL  PV   P P 
Sbjct: 400 ------PINLRFPVTPGPKPP 414



 Score = 97.9 bits (242), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 24/86 (27%), Positives = 39/86 (45%), Gaps = 5/86 (5%)

Query: 207 VGKVWYHGNLSREDAQALLKTEGD---FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH 263
               W+HG +SREDA+ +L+ EG    FLVR+S  + G YVLS         + I     
Sbjct: 5   ENLCWFHGKISREDAEEILRREGSDGVFLVRESSSSEGDYVLSVLFKGEVVHYAIRRHGD 64

Query: 264 NRVRT--RDRTFSNISELIDYHVNNG 287
           +   +         +  LI+++  + 
Sbjct: 65  DAFFSIHDHTPIHGLDSLIEHYQKDK 90


>UniRef50_UPI000044C560 PREDICTED: similar to non-catalytic region of tyrosine kinase
           adaptor protein 2 n=1 Tax=Ciona intestinalis
           RepID=UPI000044C560
          Length = 413

 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 23/109 (21%), Positives = 47/109 (43%), Gaps = 7/109 (6%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
           + +  + WY GN+ R DA+  L+     G+FLVR S+ + G Y +S +         +  
Sbjct: 309 DGIHSRDWYFGNMKRADAEQRLQDRADNGEFLVRGSETSSGDYSISMKMPGRIRHFKVNT 368

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             +       R F ++  L++++ +  +    E       + L +P+  
Sbjct: 369 LPNGVFGIGQRKFDSMDALLEHYKSAPIYTSKEQG----KVYLSKPMGR 413


>UniRef50_Q5T4P3 Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma) (Fragment)
           n=8 Tax=Euteleostomi RepID=Q5T4P3_HUMAN
          Length = 206

 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 27/115 (23%), Positives = 51/115 (44%), Gaps = 9/115 (7%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQ-SDHTPGKYVLSGRTAENEHK 255
               +  +    WY G++SRE+    L+   +G FLVR  S    G Y L+ R     +K
Sbjct: 53  MKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR-KGGNNK 111

Query: 256 HLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            + +     +    D  TF+++ ELI+++ +  +       + +  + L+ PV  
Sbjct: 112 LIKIYHRDGKYGFSDPLTFNSVVELINHYHHESL----AQYNPKLDVKLMYPVSR 162


>UniRef50_Q5VZ18 SH2 domain-containing adapter protein E n=19 Tax=Euteleostomi
           RepID=SHE_HUMAN
          Length = 495

 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 27/153 (17%), Positives = 59/153 (38%), Gaps = 11/153 (7%)

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFV--SNCRAPTVTEDVVGKVWYHGNLSR 218
            F+     S   +              + + +    S          +  + WYHG +SR
Sbjct: 343 QFEGAERPSFREETVRQHHRQKSWTQKILKPALSDHSEGEKVDPGLPLEKQPWYHGAISR 402

Query: 219 EDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT--FS 274
            +A++ L+   E  +LVR S+    +Y ++ +T++     ++     N+      +  F 
Sbjct: 403 AEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDNKYTLNQTSAVFD 462

Query: 275 NISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           +I E++ Y+ N  +  +         + L+ PV
Sbjct: 463 SIPEVVHYYSNEKLPFKGA-----EHMTLLYPV 490


>UniRef50_Q05D26 BLK protein (Fragment) n=5 Tax=Bilateria RepID=Q05D26_HUMAN
          Length = 599

 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 26/142 (18%), Positives = 48/142 (33%), Gaps = 11/142 (7%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQS 236
             R   +       SN  A    E +  + W+  +  R++A+  L       G FL+R+S
Sbjct: 96  LARSLVTGREGYVPSNFVA--RVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRES 153

Query: 237 DHTPGKYVLSGR---TAENEHKHLILL--DNHNRVRTRDRTFSNISELIDYHVNNGMAVR 291
           +   G + LS +   T     KH  +   D      +   TF ++  L+ ++   G  + 
Sbjct: 154 ETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLC 213

Query: 292 SEGRDRETSLNLIRPVPCPGSD 313
                         P      +
Sbjct: 214 QRLTLPCVRPAPQNPWAQDEWE 235


>UniRef50_UPI0000586DB6 PREDICTED: similar to ENSANGP00000020137 n=1 Tax=Strongylocentrotus
           purpuratus RepID=UPI0000586DB6
          Length = 177

 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 23/80 (28%), Positives = 45/80 (56%), Gaps = 2/80 (2%)

Query: 215 NLSREDAQALLKTEGD--FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRT 272
            ++R+ A+ LLK +GD  FL+R+S+ TPG Y LS +  +      +L D   +       
Sbjct: 27  KVTRDGAEELLKNDGDGAFLIRESEGTPGDYSLSVKFVDGVQHFKVLRDGAGKYFLWVVK 86

Query: 273 FSNISELIDYHVNNGMAVRS 292
           F+++++L++YH  + ++   
Sbjct: 87  FNSLNQLVEYHRTSSVSRSQ 106


>UniRef50_Q5DBN4 SJCHGC05332 protein n=1 Tax=Schistosoma japonicum
           RepID=Q5DBN4_SCHJA
          Length = 312

 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 28/158 (17%), Positives = 56/158 (35%), Gaps = 17/158 (10%)

Query: 147 HKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDV 206
             + +   +    +    +  ++    G        + R         +N  +      +
Sbjct: 2   EAIANYAFSPTEPDELGFEKGSTLCIVGMEEDPNWYKARQGNQEGMVPANYIS------L 55

Query: 207 VGKVWYHGNLSREDAQALL-----------KTEGDFLVRQSDHTPGKYVLSGRTAENEHK 255
               WY    SR +A+A L           + +G F++RQS++ PG + +S +   +   
Sbjct: 56  CPHPWYIPKCSRREAEARLLETDPNTHRDVQPDGAFVLRQSENDPGHFSISVKEGSSVLH 115

Query: 256 HLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSE 293
             I  D   +       FS+I+ LIDYH +  +     
Sbjct: 116 FRIFFDPSGKYYIWTNKFSSINALIDYHRHQTIYGIKA 153


>UniRef50_Q8INJ8 C-terminal Src kinase, isoform G n=6 Tax=Coelomata
           RepID=Q8INJ8_DROME
          Length = 1052

 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 35/224 (15%), Positives = 75/224 (33%), Gaps = 13/224 (5%)

Query: 88  SKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVH 147
           S  +   +             S    G +   + ++     +    +     V       
Sbjct: 563 SSSLNAAQMGMHGAERALPPKSLALSGSQHG-SNMLLHTAPQPPQASQPAAVVGVSGSGS 621

Query: 148 KLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVV 207
             +     + ++N   A +  + S+   +     M H S           R+      + 
Sbjct: 622 AGMSTSLHSFDINGVTAGSGVNASSAWSSGSTTAMNHASLSPTALAPQQGRS-RCEVKLN 680

Query: 208 GKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNR 265
              W+HG+++R++A+ LL+   +G FLVR+S + PG Y L          + +    +  
Sbjct: 681 AMPWFHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRVKYLENKL 740

Query: 266 VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
               +  F N+ +L+ ++         E         LI+ +P 
Sbjct: 741 TIDDEEYFENLGQLVAHY---------EADADGLCTQLIKCLPK 775


>UniRef50_Q0PIN0 Bam32 n=2 Tax=Branchiostoma RepID=Q0PIN0_BRABE
          Length = 250

 Score =  104 bits (259), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 28/108 (25%), Positives = 49/108 (45%), Gaps = 8/108 (7%)

Query: 205 DVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
           +V    WYHG+LSR  A+ALL     +G +L+R S    G+Y LS +  ++  KH  +  
Sbjct: 8   EVEQLDWYHGDLSRHMAEALLMANAEDGSYLLRSSATRVGEYSLSVKCKDSV-KHFQIGW 66

Query: 262 NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           +  + +     F ++ E +++  N  +     G +      L  P   
Sbjct: 67  DGKQYQFGMGVFQSLQEFVEHFANQPLI----GGESGILTALRHPYSR 110


>UniRef50_UPI0000E48523 PREDICTED: similar to protein-tyrosine kinase n=3
           Tax=Strongylocentrotus purpuratus RepID=UPI0000E48523
          Length = 837

 Score =  104 bits (259), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 35/230 (15%), Positives = 64/230 (27%), Gaps = 30/230 (13%)

Query: 93  IIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKN-------KDGTDRRCHVVFIED 145
           ++++S  I     +  +                 + K                H   ++ 
Sbjct: 236 LLEKSANINSKDSNGVTPLYTACSSNQPRACQFLMQKGADPTLRHPRTGWVPLHEAAMKG 295

Query: 146 VHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTED 205
               +  L          +  N +          P    R   H    +           
Sbjct: 296 HAGCVKELIMHGAPCHPRSADNDT----------PLDLARRYEHSHVVMYLKSCKPKVPR 345

Query: 206 VVGKVWYHGNLSREDAQALLKTEGD----FLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
           + GK W+HG++ R+ A   ++  G     FL+R S + P   VLS           I   
Sbjct: 346 LQGKPWFHGSMDRKKALESIQKHGAKDGQFLLRSSANKPDTMVLSMAANGTVFNFEINTK 405

Query: 262 NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
             +        F  + +LID++            D      L+ P+P P 
Sbjct: 406 MESFYIDDGPYFDTLEQLIDHYSR---------YDDGLPTMLLHPIPPPP 446



 Score = 91.7 bits (226), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 30/141 (21%), Positives = 51/141 (36%), Gaps = 10/141 (7%)

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNC---RAPTVTEDVVGKVWYHGNLS 217
           T + +               P        R + +S           E+    +W+HG ++
Sbjct: 23  TPEDEYGDLYPEVSTVRKDLPPLREILSKRGASLSEYLINDVAAAKEEEKDLLWFHGRIT 82

Query: 218 REDAQALLKT----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTR-DRT 272
           R+ A  +LK     EG FLVR+S    G YV+S           I        +      
Sbjct: 83  RDTAVHVLKGNGSGEGTFLVRESTSRSGDYVVSIMHNGLPQHFQIQCMGDFYYKIDNGPL 142

Query: 273 FSNISELIDYHV--NNGMAVR 291
           F  + +LI+Y+   +NG+  +
Sbjct: 143 FQGLDQLINYYRMGSNGLPTK 163


>UniRef50_Q9Y1X9 Protein tyrosine kinase n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1X9_9METZ
          Length = 573

 Score =  104 bits (259), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 33/110 (30%), Positives = 48/110 (43%), Gaps = 14/110 (12%)

Query: 205 DVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
           D+  ++WYHG +SR DA+ LL    +  G FLVR S  T G+YVLS      ++ ++I  
Sbjct: 3   DLSKELWYHGRISRLDAEQLLDNFGRLSGSFLVRDSLTTTGEYVLSLSFQGKKYHYIISR 62

Query: 261 DNHNRVRTR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                V  +    F +  ELI YH           +       L +P   
Sbjct: 63  HPDGSVAIQDGAKFDSPIELIQYHTK---------KVDGLITTLKQPCCR 103



 Score = 82.5 bits (202), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 23/112 (20%), Positives = 50/112 (44%), Gaps = 7/112 (6%)

Query: 206 VVGKVWYHGNLSREDAQALLK----TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
              ++W+HG +SRE+++  +K     +G FLVR+       + L      + + +L+ ++
Sbjct: 158 HRKQLWFHGAISREESEQRMKAFGLRDGLFLVRER-TEVNSFALCVAVKNDIYHYLLEMN 216

Query: 262 NHNRVRTR-DRTFSNISELIDYHVNNGMAVRSEGRDRETSLNL-IRPVPCPG 311
              ++     R F N+ +++D++      +     D         + VP PG
Sbjct: 217 TLGQLSIENGRKFENLLQVVDHYSRTPDGLLCTLVDVCAVTRFEAQAVPMPG 268


>UniRef50_D2A4V7 Putative uncharacterized protein GLEAN_15430 n=1 Tax=Tribolium
           castaneum RepID=D2A4V7_TRICA
          Length = 488

 Score =  104 bits (258), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 31/250 (12%), Positives = 71/250 (28%), Gaps = 24/250 (9%)

Query: 60  AAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTD 119
             +   P        + +      + +       + +                       
Sbjct: 190 PPKSTKPRSGVFCALITEARETTALEMPDHENTFVLK-------------------ANNS 230

Query: 120 TELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPA 179
            E +      +   +        I       D           DA         G     
Sbjct: 231 LEFVILARDTDDMRSWLATIKYCIRSGAGYGDTAPGDQRDYHSDAPELPPRHVSGRGGDR 290

Query: 180 PPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGD-----FLVR 234
                   +   +  +      + + +  + W+HG L R +A  L+  +G      FLVR
Sbjct: 291 LSSSSNFDMCPSTGDNISMETDIGQTLKKEFWFHGTLGRSEATNLVLHDGARGHGLFLVR 350

Query: 235 QSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
           QS+   G++VL+           + +++  + R +   F +I E++++     + + S G
Sbjct: 351 QSETRTGEFVLTFNFQGRAKHLRMTINDQGQCRVQHFWFQSIYEMLEHFRQQPIPLESGG 410

Query: 295 RDRETSLNLI 304
               T  + +
Sbjct: 411 NSDVTLTDFV 420


>UniRef50_B3XVX9 Protein tyrosine kinase tec n=1 Tax=Codonosiga gracilis
           RepID=B3XVX9_9EUKA
          Length = 642

 Score =  104 bits (258), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 39/156 (25%), Positives = 56/156 (35%), Gaps = 15/156 (9%)

Query: 154 TTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYH 213
             A N +  D +   +                S+       SN  A         + WY 
Sbjct: 204 YNATNPDDLDLKQGETLEVLSTEEEFWWRARNSAGKVGMIPSNYVA---KPGFESEPWYV 260

Query: 214 GNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRD 270
           G +SR +AQ+ L+    +G FLVR+S+ + G Y LS         + I  D +    T  
Sbjct: 261 GKMSRVEAQSKLQIFNLDGTFLVRESETSAGSYTLSVYFNGQPRNYRIQHDGNEYYITTR 320

Query: 271 RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
                I ELIDYH  NG  +            L +P
Sbjct: 321 HRQKTIKELIDYHKLNGGGLC---------TRLKKP 347


>UniRef50_UPI000186DA97 tyrosine-protein kinase transforming protein FPS, putative n=1
           Tax=Pediculus humanus corporis RepID=UPI000186DA97
          Length = 850

 Score =  104 bits (258), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 9/115 (7%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP-GKYVLSGRTAENEHKHLIL 259
              + ++ + W+HG L RE+   LL+ EGDFLVR++      + VLS       HKH I+
Sbjct: 476 NNGKALIDEEWFHGVLPREEVVRLLRHEGDFLVRETTRNDECQTVLSVAWGG--HKHFIV 533

Query: 260 LDN-HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
             N     R    +F  I ELI Y   +G+ V S      +   L +P+     +
Sbjct: 534 QTNLEGHFRFEGPSFPTIQELILYQYQSGLPVTSR-----SGAILKKPILREVWE 583


>UniRef50_B7Z8F8 cDNA FLJ50399, highly similar to GRB2-related adapter protein 2 n=5
           Tax=Homo sapiens RepID=B7Z8F8_HUMAN
          Length = 304

 Score =  104 bits (258), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 28/112 (25%), Positives = 52/112 (46%), Gaps = 2/112 (1%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLS 246
            + S  S  +          K W+H  LSR  A+ LL  K  G F++R S  +PG + +S
Sbjct: 10  RKDSNNSVSKPRHKLNPFSSKRWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSIS 69

Query: 247 GRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
            R  ++     ++ DN          F ++++L+DY+  N ++ + +   R+
Sbjct: 70  VRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRD 121


>UniRef50_P17713 Tyrosine-protein kinase STK n=5 Tax=Fungi/Metazoa group
           RepID=STK_HYDAT
          Length = 509

 Score =  104 bits (258), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 26/132 (19%), Positives = 50/132 (37%), Gaps = 16/132 (12%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK----TEGDFLVRQSDH 238
           R   +       S   AP  +     + WY G++ R +A+  L       G FL+R+++ 
Sbjct: 100 RSLITNSEGYIPSTYVAPEKSY--EAEEWYFGDVKRAEAEKRLMVRGLPSGTFLIRKAET 157

Query: 239 TPGKYVLSGRTAENEHKHLILL-DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
             G + LS R  ++   + +   D      T    F+++ EL+ ++  +   +       
Sbjct: 158 AVGNFSLSVRDGDSVKHYRVRKLDTGGYFITTRAPFNSLYELVQHYTKDADGLV------ 211

Query: 298 ETSLNLIRPVPC 309
                L  P P 
Sbjct: 212 ---CALTLPCPK 220


>UniRef50_O18683 Pi3K21B n=13 Tax=Drosophila RepID=O18683_DROME
          Length = 506

 Score =  104 bits (258), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 31/139 (22%), Positives = 62/139 (44%), Gaps = 10/139 (7%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDH 238
           P     S  R     +   P   +++    WY G +SRE+A+++L  K +G FLVR +  
Sbjct: 3   PSPLHYSTMRPQAPGSLVDP-NEDELRMAPWYWGRISREEAKSILHGKPDGSFLVRDALS 61

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRV-RTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
             G+Y L+    +   K + +     +        F+++ E+I+Y+  N +++ ++    
Sbjct: 62  MKGEYTLTLM-KDGCEKLIKICHMDRKYGFIETDLFNSVVEMINYYKENSLSMYNK---- 116

Query: 298 ETSLNLIRPVPCPGSDDIE 316
              + L  P+     +D E
Sbjct: 117 TLDITLSNPIVR-AREDEE 134



 Score = 65.2 bits (157), Expect = 3e-09,   Method: Composition-based stats.
 Identities = 22/121 (18%), Positives = 45/121 (37%), Gaps = 11/121 (9%)

Query: 191 QSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGR 248
             +       +        +W   +  R +A+ +LK    G FL+R      G Y LS  
Sbjct: 317 DKWQQLYETVSNQPHSNEALWLLKDAKRRNAEEMLKGAPSGTFLIRA--RDAGHYALSIA 374

Query: 249 TAENEHKHLILLDNHNRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
             +N  +H ++ +             ++ +  L++++ NN +    E  +   +  L  P
Sbjct: 375 C-KNIVQHCLIYETSTGFGFAAPYNIYATLKSLVEHYANNSL----EEHNDTLTTTLRWP 429

Query: 307 V 307
           V
Sbjct: 430 V 430


>UniRef50_P42685 Tyrosine-protein kinase FRK n=31 Tax=Fungi/Metazoa group
           RepID=FRK_HUMAN
          Length = 505

 Score =  104 bits (258), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 27/130 (20%), Positives = 47/130 (36%), Gaps = 11/130 (8%)

Query: 186 SSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPG 241
           S   +    SN  A      +  + W+ G + R DA+  L       G FL+R+S+   G
Sbjct: 93  SQQLQGYIPSNYVA--EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKG 150

Query: 242 KYVLSGRTAENEHKHLILLDNHNRVRTRDRT-FSNISELIDYHVNNGMAVRSEGRDRETS 300
           ++ LS         + I   +        R  FS ++E + ++      +  +       
Sbjct: 151 EFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKP--- 207

Query: 301 LNLIRPVPCP 310
             L   VP P
Sbjct: 208 -CLKIQVPAP 216


>UniRef50_Q95PW9 Temporarily assigned gene name protein 22, isoform a n=3
           Tax=Caenorhabditis RepID=Q95PW9_CAEEL
          Length = 395

 Score =  104 bits (258), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 34/153 (22%), Positives = 61/153 (39%), Gaps = 10/153 (6%)

Query: 159 VNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSR 218
               +A          +           + H+        +      +  + WY G +SR
Sbjct: 251 WMARNASGTTGLVPRNYIEVVNDSSSSKASHQDFAPQ--YSGNGEIPMEQQPWYFGRISR 308

Query: 219 EDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNI 276
           E A+ LL    EG+FLVR S+  PG   +S R  E  +KH  + +    ++  +RTF ++
Sbjct: 309 ERAEDLLLHGREGEFLVRDSESNPGDLSISMRGIER-NKHFKVQNVDGLLKIGNRTFVDM 367

Query: 277 SELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           + LI+++  + +            L L  P+P 
Sbjct: 368 NALINHYTTSPIF-----SSPTEKLFLTGPLPK 395


>UniRef50_P41240 Tyrosine-protein kinase CSK n=25 Tax=Deuterostomia RepID=CSK_HUMAN
          Length = 450

 Score =  103 bits (257), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 25/114 (21%), Positives = 45/114 (39%), Gaps = 11/114 (9%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLSGRTAEN 252
                      +    W+HG ++RE A+ LL     G FLVR+S + PG Y L       
Sbjct: 66  QKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGK 125

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
              + I+          +  F N+ +L++++ ++   +            LI+P
Sbjct: 126 VEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLC---------TRLIKP 170


>UniRef50_B5DLU5 GA27833 n=19 Tax=Bilateria RepID=B5DLU5_DROPS
          Length = 155

 Score =  103 bits (257), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 11/114 (9%)

Query: 206 VVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDN 262
           +  + W+H  +S  +A+ LL+    +G FL R S   PG + LS R   NE  H+ + +N
Sbjct: 1   MSSRRWFHPTISGIEAEKLLQEEGFDGSFLARLSSSNPGAFTLSVR-RGNEVTHIKIQNN 59

Query: 263 HNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC--PGSD 313
            +         F+ + EL+ Y++ NG      G+     + L +P+ C  P ++
Sbjct: 60  GDFFDLYGGEKFATLPELVQYYMENGELKEKNGQA----IELKQPLICAEPTTE 109


>UniRef50_UPI0000DB713D PREDICTED: similar to CG11146-PA isoform 2 n=1 Tax=Apis mellifera
            RepID=UPI0000DB713D
          Length = 1122

 Score =  103 bits (257), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 15/159 (9%)

Query: 159  VNTFDAQANASTSNDGFTVPAPPMRHRS-----SLHRQSFVSNCRAPTVTEDVVGKVWYH 213
              T +  A   T N G +   PP +         L   +   +     V   +  + WYH
Sbjct: 964  NMTLNLDAGNGTGNGGNSGQLPPKKPGGLSLGLPLEINTARGSADLVDVGLPLERQGWYH 1023

Query: 214  GNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNH-NRVRTRD 270
            G+++R +A+A+L+   EG +LVR S+ T   Y LS ++A       I  +   N      
Sbjct: 1024 GSITRIEAEAVLRLLREGSYLVRNSESTKQDYSLSLKSARGFMHMRIQKNEELNAYILGQ 1083

Query: 271  --RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
              + F +I E++ +   N + +R         + L+ PV
Sbjct: 1084 FSKPFDSIPEMVRHFSVNRLPIRGA-----EHMCLLHPV 1117


>UniRef50_P18106 Tyrosine-protein kinase Fps85D n=18 Tax=Bilateria RepID=FPS_DROME
          Length = 1325

 Score =  103 bits (257), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 32/115 (27%), Positives = 52/115 (45%), Gaps = 9/115 (7%)

Query: 201  TVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQS-DHTPGKYVLSGRTAENEHKHLIL 259
            +    +  + W+HG L RE+   LL  +GDFLVR++  +   + VLS       HKH I+
Sbjct: 950  STNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNG--HKHFIV 1007

Query: 260  LDN-HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
                    R     F++I ELI +  ++ + V       ++   L RPV     +
Sbjct: 1008 QTTGEGNFRFEGPPFASIQELIMHQYHSELPVT-----VKSGAILRRPVCRERWE 1057


>UniRef50_B3P8W2 GG12906 n=1 Tax=Drosophila erecta RepID=B3P8W2_DROER
          Length = 220

 Score =  103 bits (257), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 36/162 (22%), Positives = 63/162 (38%), Gaps = 13/162 (8%)

Query: 159 VNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSR 218
                A  +            P    ++   R   V+  +    T       W+H  +S 
Sbjct: 2   HTPHRAPLHLPLLPTCLEALMPLEPLQADQKRHGIVAEWQ--LTTPICWPTGWFHPTISG 59

Query: 219 EDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT-RDRTFS 274
            +A+ LL+    +G FL R S   PG + LS R   NE  H+ + +N +         F+
Sbjct: 60  IEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVR-RGNEVTHIKIQNNGDFFDLYGGEKFA 118

Query: 275 NISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC--PGSDD 314
            + EL+ Y++ NG      G+     + L +P+ C  P ++ 
Sbjct: 119 TLPELVQYYMENGELKEKNGQA----IELKQPLICAEPTTES 156


>UniRef50_A9UPM2 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UPM2_MONBE
          Length = 929

 Score =  103 bits (257), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 36/184 (19%), Positives = 65/184 (35%), Gaps = 12/184 (6%)

Query: 14  SSGV--SLSATYLGSVPVVESINVMVSEMRVQVVSECIQHVAATVGV--TAAREINPV-- 67
             GV  S   TY+G   V +S+  +   +R ++  E I  V           R+++    
Sbjct: 84  GEGVFYSFPVTYIGRHQVAKSLRTVEFPVRRRICQEAIARVREASNTRDPIPRDVDKASA 143

Query: 68  --VSRVIGEVKKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFG 125
             + R   ++K E+  ++I++   ++    + R+I  H  +  SF A G           
Sbjct: 144 KFLDRFEADIKLESIVINISVEGIVLATPDEDRVIAHHRMACISFAAGGDFEDY--DQVA 201

Query: 126 YIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHR 185
           YIAK K G  R C+V         +        V   + Q       + F          
Sbjct: 202 YIAKTKLG--RICYVFDCGQYSNQVLSTIGQAFVTAGEQQDLEYDEYEEFDELDEEYEAY 259

Query: 186 SSLH 189
           + + 
Sbjct: 260 TQVE 263


>UniRef50_Q8AVM4 Sh2d3c-prov protein n=7 Tax=Euteleostomi RepID=Q8AVM4_XENLA
          Length = 676

 Score =  103 bits (257), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 29/133 (21%), Positives = 49/133 (36%), Gaps = 9/133 (6%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYV 244
            +   +            + D     WYHG + RE +++L++  GDFL+R S  + G YV
Sbjct: 13  ETPPEKLHKELEEELKLNSSDPRSHAWYHGRIPREVSESLVQRNGDFLIRDSLTSLGDYV 72

Query: 245 LSGRTAENEHKHLILL--------DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRD 296
           L+ R         I              +      +F NI  L+ Y+V +   V  +   
Sbjct: 73  LTCRWKNESLHFKINKVMVKTSDSYTRIQYLFEQESFDNIPALVRYYVGSRRPVSEQSSA 132

Query: 297 RE-TSLNLIRPVP 308
                +N   P+ 
Sbjct: 133 MIYCPINRTYPLR 145


>UniRef50_UPI00017B3B48 UPI00017B3B48 related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B3B48
          Length = 325

 Score =  103 bits (257), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 20/106 (18%), Positives = 50/106 (47%), Gaps = 2/106 (1%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG--DFLVRQSDHTPGKYVLSGRTAEN 252
                P    ++    W+  N SR  A+ LL+ +G  +F++R    +PG++ +S R   +
Sbjct: 42  QEGYVPQNYIEIQTPRWFQENASRSAAEELLRHKGVGEFVIRGCQSSPGEFSISVRHESD 101

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
                ++ D+  +       F+++++L+D++  + ++   E    +
Sbjct: 102 VQHFKVMRDSRGQYFLWSEKFTSLNKLVDFYRTSSISKTREIYLND 147


>UniRef50_UPI00015B5D64 PREDICTED: similar to LD41184p n=1 Tax=Nasonia vitripennis
           RepID=UPI00015B5D64
          Length = 858

 Score =  103 bits (256), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 41/222 (18%), Positives = 71/222 (31%), Gaps = 20/222 (9%)

Query: 96  QSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTT 155
           +  L+           A     +D+      + + K             D          
Sbjct: 60  RGTLVASSSEIVLGDAAAPYSRSDSTDTIKAVGEEKAAGAAA-QPPGCRDQE----HEEP 114

Query: 156 AINVNTFDAQANASTSNDGFTVPAPPMRH-RSSLHRQSFVSNCRAPTVTEDVVGKVWYHG 214
            +      A A+  +S        P     R  L R+  + +   P    D+    WYHG
Sbjct: 115 LLLPPRGSAPASGCSSPRASMSQEPVEESVRKLLERELRLFDLIDP---RDLRSYAWYHG 171

Query: 215 NL---SREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL--------DNH 263
           +     R+ A+A +  +GDFLVR     PG YVLS R        +I             
Sbjct: 172 SSLPGGRKGAEAEIPNDGDFLVRDCSSQPGNYVLSVRHKGQALHFVINKLVLQPDTVYER 231

Query: 264 NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
            + +  D  F  +++L+ ++V +   +      R  +    R
Sbjct: 232 VQYQLEDEAFDTVADLVTFYVGSKRPISQASGARIVNPRHRR 273


>UniRef50_Q4SMI9 Chromosome 18 SCAF14547, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodon nigroviridis RepID=Q4SMI9_TETNG
          Length = 609

 Score =  103 bits (256), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 32/113 (28%), Positives = 45/113 (39%), Gaps = 13/113 (11%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL---- 260
           D+    WYHG L RE A+ALL+  GDFLVR S  TP  YVL+           I+     
Sbjct: 15  DLSSHAWYHGPLRREAAEALLERNGDFLVRDSSSTPRDYVLTCFWMNMPMHFKIIRVVLR 74

Query: 261 ----DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                +    +  +  F NI  LI  +V     +        +   +  P+  
Sbjct: 75  PKKGYSRELFQFEEDRFDNIPALIRLYVGGRRPISQA-----SGAVISHPITR 122


>UniRef50_UPI0001757D4E PREDICTED: similar to CG11146 CG11146-PA n=1 Tax=Tribolium
           castaneum RepID=UPI0001757D4E
          Length = 898

 Score =  102 bits (255), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 33/157 (21%), Positives = 59/157 (37%), Gaps = 17/157 (10%)

Query: 156 AINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGN 215
            +N+   D +           +        +         N         +  + W+HG 
Sbjct: 749 TLNLGELDLRQRPGLGLSLVGLGMNLNNPENPPTADVIDVNL-------PLEKQGWFHGA 801

Query: 216 LSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD-NHNRVRTRD-- 270
           ++R +A+ +L+   EG FLVR S+ T   Y LS ++A       I  D N          
Sbjct: 802 ITRVEAENVLRMLREGSFLVRNSESTKQDYSLSLKSARGFMHMRIQKDGNDECYILGQFS 861

Query: 271 RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           + F +I E+I +   N + +R         + L++PV
Sbjct: 862 KPFHSIPEMIRHFCINRLPIRGA-----EHMCLLQPV 893


>UniRef50_UPI00019263B9 PREDICTED: similar to phospholipase C gamma, partial n=1 Tax=Hydra
           magnipapillata RepID=UPI00019263B9
          Length = 967

 Score =  102 bits (255), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 30/122 (24%), Positives = 54/122 (44%), Gaps = 15/122 (12%)

Query: 198 RAPTVTEDVVGKVWYHGNLSREDAQALLKT----EGDFLVRQSDHTPGKYVLSGRTAENE 253
           +A    +    + W+H N+SR++A++LL+     +G FLVR S+   G + LS       
Sbjct: 309 KAGGDEDLHFSEKWFHRNISRQEAESLLQEYQRGDGSFLVRPSNMFVGDFSLSFWRKNRV 368

Query: 254 HK-HLILLDNHN----RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
              H+     ++          + F N+  LI+++  N +      +  +  L L  PVP
Sbjct: 369 QHCHIKSRPTNDGTAKYFLVGPKGFDNLYSLINHYQTNPL------KSDKFELMLTEPVP 422

Query: 309 CP 310
            P
Sbjct: 423 QP 424



 Score = 86.7 bits (213), Expect = 9e-16,   Method: Composition-based stats.
 Identities = 30/172 (17%), Positives = 50/172 (29%), Gaps = 22/172 (12%)

Query: 148 KLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVV 207
             +                       GF      + H  +   +S               
Sbjct: 366 NRVQHCHIKSRPTNDGTAKYFLVGPKGFDNLYSLINHYQTNPLKSDKFELMLTEPVPQPN 425

Query: 208 GK---VWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGK----YVLSGRTAENEHKHL 257
                 WYH NL+R  A+ +L+    +  FLVR+     G     Y +S RT     KH 
Sbjct: 426 AHLGKDWYHENLTRLQAEEMLRRMRKDSYFLVRK--RNDGDQNESYAISFRT-GGTIKHC 482

Query: 258 ILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           ++             F +++ELI ++  N +  +           L  P   
Sbjct: 483 VIKKEGRLFMIGTAPFESLTELIAHYEKNPLYRK---------TKLKYPCNQ 525


>UniRef50_B1AUG0 Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3
           n=7 Tax=Eutheria RepID=B1AUG0_MOUSE
          Length = 402

 Score =  102 bits (255), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 26/108 (24%), Positives = 49/108 (45%), Gaps = 9/108 (8%)

Query: 206 VVGKVWYHGNLSREDAQALLK--TEGDFLVRQ-SDHTPGKYVLSGRTAENEHKHLILLDN 262
           +    WY G++SRE+    L+   +G FLVR  S    G Y L+ R     +K + +   
Sbjct: 60  LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR-KGGNNKLIKIYHR 118

Query: 263 HNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
             +    +  TF+++ ELI+++ +  +       + +  + L  PV  
Sbjct: 119 DGKYGFSEPLTFTSVVELINHYHHESL----AQYNPKLDVKLTYPVSR 162



 Score = 81.3 bits (199), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 25/111 (22%), Positives = 47/111 (42%), Gaps = 10/111 (9%)

Query: 201 TVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
                   K W+  +++R  A+ LL  K +G FL+R+S    G Y  S   A+ E KH +
Sbjct: 289 ENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRES-SKKGCYACSV-VADGEVKHCV 346

Query: 259 LLDNHNRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
           +          +    +S++ EL+ ++    +       +   ++ L  PV
Sbjct: 347 IYSTARGYGFAEPYNLYSSLKELVLHYQQTSLV----QHNDSLNVRLAYPV 393


>UniRef50_A2IB48 Phospholipase C gamma n=5 Tax=Eumetazoa RepID=A2IB48_CHAVR
          Length = 1322

 Score =  102 bits (255), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 31/138 (22%), Positives = 48/138 (34%), Gaps = 19/138 (13%)

Query: 187 SLHRQSFVSNCRAPTVTEDVVGKVWYHGNL--SREDAQALLKT-----EGDFLVRQSDHT 239
                            E    + W+HG L   R  A+ LLK      +G FLVR+SD  
Sbjct: 536 EEESNDTSLQLEGLGNDEMHFSEKWFHGKLEGGRRKAEDLLKEYSYLGDGTFLVRESDTF 595

Query: 240 PGKYVLSGRTAENEHKHLILLDNH-----NRVRTRDRTFSNISELIDYHVNNGMAVRSEG 294
            G + LS    ++   H  +               +  F ++  LI ++    +      
Sbjct: 596 VGDFSLSF-WRKDSVNHCRIRSKQERGQTKYYLIDNLAFDSLYSLITHYQKYPL------ 648

Query: 295 RDRETSLNLIRPVPCPGS 312
           R ++    L  PVP P S
Sbjct: 649 RSQDFQQILKEPVPQPQS 666



 Score = 99.1 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 38/197 (19%), Positives = 62/197 (31%), Gaps = 21/197 (10%)

Query: 114 GQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSND 173
           G           ++        R+  V       K     T    ++     +  S    
Sbjct: 583 GDGTFLVRESDTFVGDFSLSFWRKDSVNHCRIRSKQERGQTKYYLIDNLAFDSLYSLITH 642

Query: 174 GFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKT---EGD 230
               P           +             +   GK WYH  L R  A+ +LK    +G 
Sbjct: 643 YQKYPLR--------SQDFQQILKEPVPQPQSHHGKPWYHEKLDRTRAEDMLKRIPSDGA 694

Query: 231 FLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAV 290
           FLVRQ+      Y +S R AE + KH I+          +  F ++ EL++Y+    +  
Sbjct: 695 FLVRQNGVDTNSYAISFR-AEGKIKHCIIKQEGRLFTIGNAQFESLVELVNYYEKKPLYR 753

Query: 291 RSEGRDRETSLNLIRPV 307
           +         + L  PV
Sbjct: 754 K---------MKLKHPV 761


>UniRef50_Q05DQ0 PIK3R3 protein (Fragment) n=19 Tax=Chordata RepID=Q05DQ0_HUMAN
          Length = 283

 Score =  102 bits (254), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 27/115 (23%), Positives = 51/115 (44%), Gaps = 9/115 (7%)

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQ-SDHTPGKYVLSGRTAENEHK 255
               +  +    WY G++SRE+    L+   +G FLVR  S    G Y L+ R     +K
Sbjct: 53  MKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLR-KGGNNK 111

Query: 256 HLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            + +     +    D  TF+++ ELI+++ +  +       + +  + L+ PV  
Sbjct: 112 LIKIYHRDGKYGFSDPLTFNSVVELINHYHHESL----AQYNPKLDVKLMYPVSR 162


>UniRef50_UPI00015B496D PREDICTED: similar to conserved hypothetical protein n=3
            Tax=Coelomata RepID=UPI00015B496D
          Length = 1182

 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 10/126 (7%)

Query: 187  SLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYV 244
            SL   +   +     V   +  + WYHG+++R +A+A+L+   EG +LVR S+ T   Y 
Sbjct: 1057 SLELTASRGSADLVDVELPLERQGWYHGSITRIEAEAVLRLLREGSYLVRNSESTKQDYS 1116

Query: 245  LSGRTAENEHKHLILLDNH-NRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSL 301
            LS ++A       I  +   N        + F +I E++ +   N + +R         +
Sbjct: 1117 LSLKSARGFMHMRIQKNEELNAYILGQFSKPFDSIPEMVRHFSINRLPIRGA-----EHM 1171

Query: 302  NLIRPV 307
             L+ PV
Sbjct: 1172 CLLHPV 1177


>UniRef50_Q4SAX0 Chromosome 3 SCAF14679, whole genome shotgun sequence. (Fragment)
           n=2 Tax=Tetraodontidae RepID=Q4SAX0_TETNG
          Length = 283

 Score =  102 bits (254), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 20/106 (18%), Positives = 50/106 (47%), Gaps = 2/106 (1%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG--DFLVRQSDHTPGKYVLSGRTAEN 252
                P    ++    W+  N SR  A+ LL+ +G  +F++R    +PG++ +S R   +
Sbjct: 42  QEGYVPQNYIEIQTPRWFQENASRSAAEELLRHKGVGEFVIRGCQSSPGEFSISVRHESD 101

Query: 253 EHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
                ++ D+  +       F+++++L+D++  + ++   E    +
Sbjct: 102 VQHFKVMRDSRGQYFLWSEKFTSLNKLVDFYRTSSISKTREIYLND 147


>UniRef50_Q60I21 TEC family protein tyrosine kinase n=1 Tax=Eptatretus burgeri
           RepID=Q60I21_EPTBU
          Length = 636

 Score =  102 bits (253), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 37/155 (23%), Positives = 52/155 (33%), Gaps = 19/155 (12%)

Query: 167 NASTSNDGFTVPAPPMRHRSSL-HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL 225
              T            R +          S    P    D+    W+  +++R  A+ LL
Sbjct: 216 KGCTYVILDDKNPHWWRAQDEEGREGLIPSTYVYPLTRFDLEQNRWFCKDITRAKAEQLL 275

Query: 226 KT---EGDFLVRQSDHTPGKYVLSG--RTAENEHKHLILLD--NHNRVRTRDRTFSNISE 278
           +    EG FLVR+S    GK  +S          KH  +              TFS IS+
Sbjct: 276 RQAGSEGSFLVRES-SQVGKLTVSVYSCIPCEVVKHYHVKQLPTGEWYLAEKHTFSTISD 334

Query: 279 LIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           LI YH +N   +            L  PV  PG +
Sbjct: 335 LIHYHQHNAAGLV---------TRLRHPV-RPGEE 359


>UniRef50_UPI0000F2151D PREDICTED: similar to SH2B adapter protein 3 (Lymphocyte-specific
           adapter protein Lnk) (Signal transduction protein Lnk)
           (Lymphocyte adapter protein) n=2 Tax=Danio rerio
           RepID=UPI0000F2151D
          Length = 596

 Score =  102 bits (253), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 34/172 (19%), Positives = 62/172 (36%), Gaps = 16/172 (9%)

Query: 150 IDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP--------- 200
            D      +  T   +  +S S++    P P     S+  R S     ++P         
Sbjct: 364 ADNEQQVSSWTTELRECMSSRSDNVDGEPFPVSDSLSAARRGSSDPGGQSPLGFGLAEQA 423

Query: 201 --TVTEDVVGKVWYHGNLSREDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENE 253
                  +    W+HG +SR  A  L++       G+FLVRQS+   G YVL+       
Sbjct: 424 YNKTHHFLSSYSWFHGPISRVRAAYLVQHAGVSGHGNFLVRQSETRRGDYVLTFNYQGRA 483

Query: 254 HKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
               + L    + R +   F ++ +++ +  N  + +           N +R
Sbjct: 484 KHLRLSLTEWGQCRVQHLRFPSVMDMLSHFRNCPIPLECGAACDVMLANYVR 535


>UniRef50_UPI00016E9A01 UPI00016E9A01 related cluster n=3 Tax=Tetraodontidae
           RepID=UPI00016E9A01
          Length = 580

 Score =  102 bits (253), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 33/165 (20%), Positives = 59/165 (35%), Gaps = 16/165 (9%)

Query: 151 DVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTV-------- 202
           D   ++      +   N S   D   +P+PP     S  R S   + + P          
Sbjct: 295 DQQVSSWTTEIKECINNRSGGADLEPLPSPPDVSAPSSQRGSTELSSQGPAPLPMPEQVV 354

Query: 203 ---TEDVVGKVWYHGNLSREDAQALLKT-----EGDFLVRQSDHTPGKYVLSGRTAENEH 254
                 +    W+HG +SR  A  L+++      G FLVRQS+   G YVL+        
Sbjct: 355 QKTDHFLFSYPWFHGPISRVKAAYLVQSSGPEGHGVFLVRQSETRRGDYVLTFNYQGKAK 414

Query: 255 KHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET 299
              + L    + R +   F ++ +++ +     + +        T
Sbjct: 415 HLRLSLTEWGQCRVQHLRFPSVMDMLSHFRLFPIPLECGAAGAVT 459


>UniRef50_UPI000194E163 PREDICTED: similar to GRAP2 n=1 Tax=Taeniopygia guttata
           RepID=UPI000194E163
          Length = 312

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 22/112 (19%), Positives = 51/112 (45%), Gaps = 2/112 (1%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG--DFLVRQSDHTPGKYVLS 246
             +        P    D     W+   +SR +A+ LL ++G   F+VR S ++ G + +S
Sbjct: 51  KAELRSHEGYVPKNFIDFHVPHWFDEKISRHEAENLLMSKGVGCFVVRASQNSHGDFSIS 110

Query: 247 GRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
            R  ++     ++ D+          F ++++L+DY+  + ++ + +   R+
Sbjct: 111 VRHEDDVQHFKVMRDSKGSYYLWTEKFHSLNKLVDYYKTSSISRQKQIFLRD 162


>UniRef50_UPI00017B1E0A UPI00017B1E0A related cluster n=1 Tax=Tetraodon nigroviridis
           RepID=UPI00017B1E0A
          Length = 680

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 32/113 (28%), Positives = 45/113 (39%), Gaps = 13/113 (11%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL---- 260
           D+    WYHG L RE A+ALL+  GDFLVR S  TP  YVL+           I+     
Sbjct: 15  DLSSHAWYHGPLRREAAEALLERNGDFLVRDSSSTPRDYVLTCFWMNMPMHFKIIRVVLR 74

Query: 261 ----DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                +    +  +  F NI  LI  +V     +        +   +  P+  
Sbjct: 75  PKKGYSRELFQFEEDRFDNIPALIRLYVGGRRPISQA-----SGAVISHPITR 122


>UniRef50_Q4T6N5 Chromosome 9 SCAF8684, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4T6N5_TETNG
          Length = 966

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 43/252 (17%), Positives = 76/252 (30%), Gaps = 49/252 (19%)

Query: 76  KKENFPVDINISSKMIKIIKQSRLIQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTD 135
                 +  +I + ++ +         H +    F     K   +E        + +   
Sbjct: 518 PYSENDISNSIKNGILYLEDPI----NHEWYPHFFVLTSSKIYYSEETSSNQGNDDEEEH 573

Query: 136 RRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVS 195
           +       +       VL T +           S      T P   +           + 
Sbjct: 574 KEVRRPERKKKSSFSRVLLTDL-----------SLRLRPPTFPDRLV---------LVLV 613

Query: 196 NCRAPTVTEDVVGKVWYHGNLS-----REDAQALLK--------TEGDFLVRQSDHTPGK 242
           N +A    +  V + W+HG L      R+ A+ LL          +G FLVR+S+   G 
Sbjct: 614 NFQASNGMDQHVTEKWFHGKLGAGRDGRQIAERLLSEYCMETGAPDGSFLVRESETFVGD 673

Query: 243 YVLSGRTAENEHKHLILLDNH-----NRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
           Y LS        +H  +             T +  F  +  LI+++    +      R  
Sbjct: 674 YTLSF-WRSGRVQHCRIHSRQEAGSPKFYLTDNLVFDTLFALINHYQQVAL------RCN 726

Query: 298 ETSLNLIRPVPC 309
           E  + L  PVP 
Sbjct: 727 EFEMKLTEPVPQ 738



 Score = 92.9 bits (229), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 39/219 (17%), Positives = 64/219 (29%), Gaps = 29/219 (13%)

Query: 96  QSRLIQRHPFSFFSFGAQG-QKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLT 154
             R I     S +                  ++        R   V              
Sbjct: 639 DGRQIAERLLSEYCMETGAPDGSFLVRESETFVGDYTLSFWRSGRVQHCR---------- 688

Query: 155 TAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSN---CRAPTVTEDVVGKVW 211
              +     +     T N  F      + H   +  +              T     K W
Sbjct: 689 -IHSRQEAGSPKFYLTDNLVFDTLFALINHYQQVALRCNEFEMKLTEPVPQTNAHESKEW 747

Query: 212 YHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           YH NLSR  A+ +L     +G FLVR+    P  + +S R AE + KH  +      V  
Sbjct: 748 YHANLSRSQAENMLMRVPRDGAFLVRKRA-EPNSFAISFR-AEGKIKHCRVQQEGQTVVL 805

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
               F ++ +LI Y+  + +  +         + L  P+
Sbjct: 806 GTSEFDSLVDLISYYEKHPLYRK---------MKLRYPI 835


>UniRef50_UPI00019266B8 PREDICTED: similar to Bam32 n=1 Tax=Hydra magnipapillata
           RepID=UPI00019266B8
          Length = 237

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 31/115 (26%), Positives = 48/115 (41%), Gaps = 8/115 (6%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
           + + V    W+H NL R  A+ALL     +G +L+R   +    YVLS R A +  KH  
Sbjct: 1   MEDRVEDLGWFHSNLDRHQAEALLLHNGQDGSYLLRICTNNENSYVLSCRCANSV-KHFQ 59

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
           +  +    R     F   SEL+ +  N  +     G +      L  P P   ++
Sbjct: 60  ISYDGKYYRFGMAIFETFSELVKHFENQPLL----GGESGVLTLLKYPYPRRVNE 110


>UniRef50_A8QHB6 SH2 domain containing protein (Fragment) n=1 Tax=Brugia malayi
           RepID=A8QHB6_BRUMA
          Length = 338

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 33/125 (26%), Positives = 56/125 (44%), Gaps = 19/125 (15%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGK 242
           ++S+ R+   +N + P +        WYHGN++RE  + +L  + +G FLVR S + PG 
Sbjct: 28  QTSVDRRYVANNEQHPKL--------WYHGNITREHTEKILSGQADGTFLVRDSTNFPGD 79

Query: 243 YVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLN 302
           Y L          + I   N       + TF N+++LI ++  +   +            
Sbjct: 80  YTLCMAFNGKVEHYRIYQLNGILTCDHEETFDNLTQLIAHYKRDADGLCH---------R 130

Query: 303 LIRPV 307
           LI PV
Sbjct: 131 LITPV 135


>UniRef50_Q06187 Tyrosine-protein kinase BTK n=57 Tax=Gnathostomata RepID=BTK_HUMAN
          Length = 659

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 39/179 (21%), Positives = 64/179 (35%), Gaps = 21/179 (11%)

Query: 143 IEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPA-PPMRHRSSLHRQSFVSNCRAPT 201
                K +  L   + +N  D Q               P  R R    ++ ++ +     
Sbjct: 212 STSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTE 271

Query: 202 VTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTA-----ENE 253
             + +    WY  +++R  A+ LLK    EG F+VR S    GKY +S         +  
Sbjct: 272 AEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGV 330

Query: 254 HKHLILL-DNHNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCP 310
            +H ++     ++        FS I ELI+YH +N   + S          L  PV   
Sbjct: 331 IRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLIS---------RLKYPVSQQ 380


>UniRef50_Q4S6Q5 Chromosome undetermined SCAF14724, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4S6Q5_TETNG
          Length = 803

 Score =  101 bits (252), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 29/133 (21%), Positives = 50/133 (37%), Gaps = 13/133 (9%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYV 244
             S  +             E++    WYHG + R+ A+ L++ +GDFL+R S  +PG YV
Sbjct: 10  ECSSEKLRKELEEELKMDCEELRSHAWYHGAIPRQVAENLVQRDGDFLIRDSLSSPGSYV 69

Query: 245 LSGRTAENEHKHLILL--------DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRD 296
           L+ +         I                R     F ++  LI ++V N   V      
Sbjct: 70  LTSQWRNTAQHFKINKKVVALNEAYTRVEFRLEREGFDSVPALIRFYVGNRKPVS----- 124

Query: 297 RETSLNLIRPVPC 309
           +     + +P+  
Sbjct: 125 QVVGAIIFQPINR 137


>UniRef50_Q24145 Tyrosine-protein kinase shark n=5 Tax=melanogaster subgroup
           RepID=SHARK_DROME
          Length = 939

 Score =  101 bits (251), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 45/309 (14%), Positives = 88/309 (28%), Gaps = 45/309 (14%)

Query: 36  MVSEMRVQVVSECIQHVAATVGVTAAREINPVVSRVI----GEVKKENFPVDINISSKMI 91
                R   V+  +    +        E+     R       + +       ++    ++
Sbjct: 111 PPHNTRSHGVTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDIL 170

Query: 92  KIIKQSRL-IQRHPFSFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLI 150
           K +  +++ +               +      +   I+   +   R     ++  +H+  
Sbjct: 171 KHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVP-LHEAA 229

Query: 151 DVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKV 210
                        A+A           P    +       + F+ N + P          
Sbjct: 230 KHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTT--RDQ 287

Query: 211 WYHGNLSREDAQALLKTE--------------GDFLVRQSDH-TPGKYVLSGRTAENEHK 255
           WYHG L+RE+A A+LK                G FLVR S+       VL+    +    
Sbjct: 288 WYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKN 347

Query: 256 HLI----LLDNHNRVRTRDRTF---------SNISELIDYHVNNGMAVRSEGRDRETSLN 302
             I    L  N N+V++    F          ++  LI + +                ++
Sbjct: 348 FRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMR---------FSYGLPVS 398

Query: 303 LIRPVPCPG 311
           L  PVP   
Sbjct: 399 LKYPVPPQP 407



 Score = 91.7 bits (226), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 33/117 (28%), Positives = 49/117 (41%), Gaps = 14/117 (11%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
           ++ D     WYHGNLSRE A  LLK    +G FLVR+S    G +VLS         + +
Sbjct: 1   MSRDSDPMKWYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQV 60

Query: 259 LLD--NHNRVRTRDRT----FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                        D+        +  L+DY+        + G   + ++ LIR +P 
Sbjct: 61  RRHGGEDAFFSIDDKVQTKILHGLDTLVDYYQQ-----AANGLPTKLTVPLIRDLPP 112


>UniRef50_UPI0000DB7594 PREDICTED: similar to CG9098-PA, isoform A n=1 Tax=Apis mellifera
           RepID=UPI0000DB7594
          Length = 797

 Score =  101 bits (251), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 35/163 (21%), Positives = 57/163 (34%), Gaps = 21/163 (12%)

Query: 158 NVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNL- 216
           N     A     + +       PP      L  +             D+    WYHG+  
Sbjct: 100 NGREESAARRVDSHDYSNLPMDPPEESTRKLLERELRL-----LDPRDLRSHAWYHGSTL 154

Query: 217 --SREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL--------DNHNRV 266
              R+ A+A +  +GDFLVR     PG YVL+ R        +I              + 
Sbjct: 155 RGGRKGAEAEVPNDGDFLVRDCASQPGNYVLTVRWKGQPLHFVINRVVIQPETVYERAQY 214

Query: 267 RTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           +  D  F  +++LI ++V +G  +        +   +I P P 
Sbjct: 215 QFEDEAFDTVADLITFYVGSGRPISQA-----SGARIITPKPR 252


>UniRef50_B4DVK9 cDNA FLJ53479, highly similar to Proto-oncogene vav n=1 Tax=Homo
           sapiens RepID=B4DVK9_HUMAN
          Length = 748

 Score =  101 bits (251), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 31/139 (22%), Positives = 60/139 (43%), Gaps = 11/139 (7%)

Query: 183 RHRSSLHRQSFVSNCRAPTVT---EDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSD 237
           R+ S+     F  N   P V    +D+   +WY G + R  A+++L  +++G FLVRQ  
Sbjct: 543 RNTSTNEIGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRV 602

Query: 238 HTPGKYVLSGRTAENEHKHLILLDNHNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRD 296
               ++ +S +    E KH+ ++      R    + F  ++EL++++  N +    +  D
Sbjct: 603 KDAAEFAISIKYNV-EVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLD 661

Query: 297 RETSLNLIRP----VPCPG 311
                    P    +  P 
Sbjct: 662 TTLQFPFKEPEKRTISRPA 680


>UniRef50_Q9H6Q3 Src-like-adapter 2 n=19 Tax=Eutheria RepID=SLAP2_HUMAN
          Length = 261

 Score =  101 bits (251), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 36/174 (20%), Positives = 58/174 (33%), Gaps = 13/174 (7%)

Query: 148 KLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVV 207
           +       A+        A  S                 ++  +        P+V    V
Sbjct: 31  ERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKV 90

Query: 208 GKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGR----TAENEHKHLIL 259
              W +  LSRE A+ LL       G FL+R+S    G Y LS R     + +  +H  +
Sbjct: 91  SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRI 150

Query: 260 L--DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
              DN     +   TF ++  L+D++      +       +    L R  P PG
Sbjct: 151 HCLDNGWLYISPRLTFPSLQALVDHYSELADDIC---CLLKEPCVLQRAGPLPG 201


>UniRef50_UPI00006A1A97 SH2B adapter protein 2 (SH2 and PH domain-containing adapter
           protein APS) (Adapter protein with pleckstrin homology
           and Src homology 2 domains). n=3 Tax=Xenopus (Silurana)
           tropicalis RepID=UPI00006A1A97
          Length = 591

 Score =  101 bits (251), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 28/126 (22%), Positives = 51/126 (40%), Gaps = 18/126 (14%)

Query: 205 DVVGKVWYHGNLSREDAQALL-----KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
           ++    W+HG LSR  A  L+     ++ G F++RQS+  PG+YVL+           + 
Sbjct: 457 NLSDFPWFHGTLSRIRAAQLVLSGGTRSHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLS 516

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRET-------------SLNLIRP 306
           L+   +   +   F  I +++ +  ++ + + S G    T                   P
Sbjct: 517 LNETGQCHVQHLWFQTIFDMLKHFHSHPIPLESGGSADITLRSFVVAQRQLSDPAPPQNP 576

Query: 307 VPCPGS 312
           V  P S
Sbjct: 577 VSPPES 582


>UniRef50_Q7T0U4 MGC68984 protein n=2 Tax=Xenopus RepID=Q7T0U4_XENLA
          Length = 266

 Score =  100 bits (250), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 29/129 (22%), Positives = 52/129 (40%), Gaps = 10/129 (7%)

Query: 195 SNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE----GDFLVRQSDHTPGKYVLSGR-- 248
             C  PT     V   W +  ++RE A+ LL       G FL+R+S+   G Y LS R  
Sbjct: 73  QECYLPTNYVAKVCNRWLYKGINREKAEELLMVNSNRSGSFLIRESETRSGSYTLSIRKT 132

Query: 249 ---TAENEHKHLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
              + ++   + I   ++       R TF+ + +++DY+      +     +      + 
Sbjct: 133 NHTSRDSIKHYRIHQLDNGWFYIAPRLTFATLQDMVDYYSEVADGICCTLTEPCVVQRVP 192

Query: 305 RPVPCPGSD 313
            PV    S+
Sbjct: 193 NPVIQRPSE 201


>UniRef50_UPI000179EA7A UPI000179EA7A related cluster n=1 Tax=Bos taurus
           RepID=UPI000179EA7A
          Length = 279

 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 37/213 (17%), Positives = 73/213 (34%), Gaps = 16/213 (7%)

Query: 114 GQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSND 173
           G +    +  F    K        C   +      L             +       +  
Sbjct: 10  GYECFHVKNFFKLKKKRGLPKMEVCQEYY-----GLPPPPGAIGPFLRLNPGDIVELTKA 64

Query: 174 GFTVPAPPMRHRSSLHRQSFVSNCRAPTVT---EDVVGKVWYHGNLSREDAQALL--KTE 228
                    R+ S+     F  N   P V    +D+   +WY G + R  A+++L  +++
Sbjct: 65  EAEQNWWEGRNISTNEVGWFPCNRVKPYVHGPPQDLSVHLWYAGPMERAGAESILTNRSD 124

Query: 229 GDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT-RDRTFSNISELIDYHVNNG 287
           G FLVRQ      ++ +S +    E KH+ ++      R    + F  ++EL++++  N 
Sbjct: 125 GTFLVRQRVKDAAEFAISIKYNV-EVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNS 183

Query: 288 MAVRSEGRDRETSLNLIRP----VPCPGSDDIE 316
           +    +  D         P    +  P +  I+
Sbjct: 184 LKDCFKSLDTTLQFPFKEPERRAINKPSAGSIK 216


>UniRef50_A9V510 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V510_MONBE
          Length = 558

 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 42/291 (14%), Positives = 82/291 (28%), Gaps = 58/291 (19%)

Query: 50  QHVAATVGVTAAREINPVVSRVIGEVKKENFPVDINISSKMIKIIKQS----RLIQRHPF 105
                        E N  V R+    K+    V        ++ +  S     +I  +  
Sbjct: 19  WQPTQAQPRPGLIEANACVKRLFVRPKQSRLSVISCSPDGGLQCVDTSYNPPEVILNN-- 76

Query: 106 SFFSFGAQGQKGTDTELMFGYIAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTF--- 162
           S +     G   +   L    + K +   D  CHV            +    +  T    
Sbjct: 77  SVYEIAHCGVDVSKPRLFTVIVGKKESS-DFFCHVFKCASKDSAARFVKAVASACTLAYQ 135

Query: 163 ------------------------------------------DAQANASTSNDGFTVPAP 180
                                                      A   +S           
Sbjct: 136 NYQKKKSAASGGRGSGSGAPAQAPARGSVSHNRAPASSSGVKSAHIRSSMRRPVGGKDRR 195

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQSDH 238
            +R+     + + + +              W+  ++SR +  ++L+    GDF+VR+S  
Sbjct: 196 EVRNGKPNPKLTHLISSGRVARAAHTFQDSWFRPSMSRAEVASILRGGRIGDFIVRESQT 255

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRVRTRDR---TFSNISELIDYHVNN 286
            PG Y +S +T       LI        +  +R   +F+ +++LI ++  N
Sbjct: 256 RPGDYAISVQTGAQIWTGLIPHAPRG-FQLGERGGVSFAELTDLIAHYAQN 305


>UniRef50_P08630 Tyrosine-protein kinase Btk29A n=23 Tax=Neoptera RepID=BTKL_DROME
          Length = 786

 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 36/126 (28%), Positives = 56/126 (44%), Gaps = 12/126 (9%)

Query: 191 QSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSG 247
               SN   P     +    WY G++SR+ A++LLK    EG F+VR+S    G Y LS 
Sbjct: 390 GYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTK-GLYTLSL 448

Query: 248 --RTAENEHKHLILLDN--HNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNL 303
             +  ++  KH  +  N       +       I +LI+YH +N   +    R + +  + 
Sbjct: 449 HTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGL--ACRLKSSPCD- 505

Query: 304 IRPVPC 309
            RPVP 
Sbjct: 506 -RPVPP 510


>UniRef50_UPI0001924162 PREDICTED: similar to SH2-B PH domain containing signaling mediator
           1 n=1 Tax=Hydra magnipapillata RepID=UPI0001924162
          Length = 984

 Score =  100 bits (250), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 26/164 (15%), Positives = 57/164 (34%), Gaps = 13/164 (7%)

Query: 147 HKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDV 206
              +         N   +Q + +       V +P    +                    +
Sbjct: 766 QAPVQNPKVINGYNITSSQDSQAAPITTPEVLSPIPETQCDWTNPFGE--------NHPL 817

Query: 207 VGKVWYHGNLSR-EDAQALLKT----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
               W+HG ++R + +  +L+      G FLVRQS+   G+YVL+           + L+
Sbjct: 818 AVYPWFHGTITRVQSSMHVLQQGSSWHGVFLVRQSETRRGEYVLTFNLQGRSKHLRMSLN 877

Query: 262 NHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
           +    R +   F  I +++++   + + + + G D       + 
Sbjct: 878 SEGNCRVQHLRFETIFDMLEHFRLHPIPLENNGSDDVRLTGYVY 921


>UniRef50_UPI00006A5E95 PREDICTED: similar to HrSH2 n=1 Tax=Ciona intestinalis
           RepID=UPI00006A5E95
          Length = 572

 Score =  100 bits (249), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 33/139 (23%), Positives = 59/139 (42%), Gaps = 13/139 (9%)

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTP 240
           P   +S   +++   + ++   T+++   +WYH  L RE+AQA++  +GDFL+RQS  + 
Sbjct: 16  PTFPQSVETQKNLYRDVKSSNNTKEISNCLWYHFKLRREEAQAMVVNDGDFLLRQSLSSV 75

Query: 241 GKYVLSGRTAENEHKHLILL--------DNHNRVRTRDRTFSNISELIDYHVNNGMAVRS 292
             YVL+ R         I          ++          F +I  LI YH+ N + +  
Sbjct: 76  DDYVLTLRWNATVLHFKINKFVQRHDAVNSSTFFVFERAYFDSIYSLIMYHMENQIPIS- 134

Query: 293 EGRDRETSLNLIRPVPCPG 311
                 T   +  P+    
Sbjct: 135 ----VLTGALIQHPITRQT 149


>UniRef50_Q4SBL7 Chromosome 15 SCAF14667, whole genome shotgun sequence. (Fragment)
           n=1 Tax=Tetraodon nigroviridis RepID=Q4SBL7_TETNG
          Length = 723

 Score =  100 bits (249), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 30/134 (22%), Positives = 54/134 (40%), Gaps = 11/134 (8%)

Query: 180 PPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQ-S 236
           PP+        +   S       +  +    WY G +SRE+    L+   +G FLVR  S
Sbjct: 333 PPVLPAKPAKSKVAPS--AMTDTSSLLNDAEWYWGEISREEVNEKLRDTPDGTFLVRDAS 390

Query: 237 DHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDR-TFSNISELIDYHVNNGMAVRSEGR 295
               G+Y L+ R     +K + +     R    +  TF ++ ELI+++ +  +       
Sbjct: 391 SKLEGEYTLTLR-KGGNNKLIKIYHREGRYGFSEPLTFLSVVELINHYRHESL----AQY 445

Query: 296 DRETSLNLIRPVPC 309
           + +    L+ PV  
Sbjct: 446 NAKLDTKLLYPVSK 459



 Score = 82.1 bits (201), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 22/116 (18%), Positives = 48/116 (41%), Gaps = 9/116 (7%)

Query: 196 NCRAPTVTEDVVGKVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENE 253
           +      +       WY G++ R  A+ +L+   +G FL+R+S    G Y  S    + +
Sbjct: 607 SLEEDESSPHHDESTWYVGDIKRSQAEEMLRGTCDGTFLIRESQTQKGSYACSVVV-DGD 665

Query: 254 HKHLILLDNHNRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
            KH ++          +    +S++ +L+ ++ N  +       +   ++ L  PV
Sbjct: 666 TKHCVVYKTVTGYGFAEPYNLYSSLKDLVLHYKNVSLV----QHNDHLNVTLAHPV 717


>UniRef50_Q5BXT3 SJCHGC03955 protein (Fragment) n=2 Tax=Schistosoma
           RepID=Q5BXT3_SCHJA
          Length = 190

 Score =  100 bits (249), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 34/180 (18%), Positives = 62/180 (34%), Gaps = 19/180 (10%)

Query: 142 FIEDVHKLIDVLTTAINVNTFDAQAN-ASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAP 200
                      L    +    ++  N    SN    +    M+ R+         +    
Sbjct: 2   SAPSKQIYPQHLAACESAEKPNSSVNAPCLSNSQAIITNDHMQPRTQNVSNKAPVHHVMM 61

Query: 201 TVTEDVVG------KVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAEN 252
             +   +         WYHG +SR+  + LL++   G FLVR S+  PG+  ++ R    
Sbjct: 62  DSSPLSLLEPSLLSYSWYHGAVSRQAGEHLLRSGITGSFLVRASESAPGQLSVTVRHLGR 121

Query: 253 EHKHLILLDNHN-RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPG 311
            + + I  D+      T    F  + +LI++H  +   +            L+  VP P 
Sbjct: 122 VYHYRISQDSRGLFYITEAHRFPTVVQLIEHHSRSADGLV---------CPLLYSVPKPQ 172


>UniRef50_Q573B4 Proto-oncogene tyrosine-protein kinase LCK n=6 Tax=Coelomata
           RepID=Q573B4_HUMAN
          Length = 516

 Score =  100 bits (248), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 32/150 (21%), Positives = 52/150 (34%), Gaps = 10/150 (6%)

Query: 146 VHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTED 205
              L+  L +    +  D                   + +S    Q              
Sbjct: 120 TDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANS 179

Query: 206 VVGKVWYHGNLSREDAQALL----KTEGDFLVRQSDHTPGKYVLSGR----TAENEHKHL 257
           +  + W+  NLSR+DA+  L     T G FL+R+S+ T G + LS R          KH 
Sbjct: 180 LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHY 239

Query: 258 ILL--DNHNRVRTRDRTFSNISELIDYHVN 285
            +   DN     +   TF  + EL+ ++  
Sbjct: 240 KIRNLDNGGFYISPRITFPGLHELVRHYTR 269


>UniRef50_UPI00019269FE PREDICTED: similar to protein tyrosine phosphatase, non-receptor
           type 11 n=1 Tax=Hydra magnipapillata RepID=UPI00019269FE
          Length = 544

 Score =  100 bits (248), Expect = 8e-20,   Method: Composition-based stats.
 Identities = 34/163 (20%), Positives = 68/163 (41%), Gaps = 21/163 (12%)

Query: 161 TFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRA----------PTVTEDVVGKV 210
           T D ++     NDGF      + +      +    N ++                +  + 
Sbjct: 64  TNDGESFGLYENDGFASVPDLIEYYQHNPSKFLDQNNKSVELTEPLIDDSENDPGLSQEK 123

Query: 211 WYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVR 267
           W+ G + R +A+ +LK     G +LVR+S   PG +VLS R   +  + L++  +     
Sbjct: 124 WFFGEIGRGEAELILKQRGEHGSYLVRESRTQPGNFVLSVRHHNSVIEFLLI-YSDGAFD 182

Query: 268 TRDR---TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
             +     F  ++ LI+Y + N +      +D + +++LI P+
Sbjct: 183 IANTKRLKFPTMTHLINYFITNPLI----HKDSDQAIHLIEPL 221



 Score = 89.8 bits (221), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 27/106 (25%), Positives = 48/106 (45%), Gaps = 6/106 (5%)

Query: 212 YHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           +  NL+  +A++LLK     G +L R+S  +PG Y LS R  +      I  D  +    
Sbjct: 14  FFANLTVAEAESLLKEKGNHGSYLCRRSTSSPGSYTLSVRRQKEVWNFKITNDGESFGLY 73

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDD 314
            +  F+++ +LI+Y+ +N             S+ L  P+     +D
Sbjct: 74  ENDGFASVPDLIEYYQHNP---SKFLDQNNKSVELTEPLIDDSEND 116


>UniRef50_A7T185 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7T185_NEMVE
          Length = 983

 Score =  100 bits (248), Expect = 8e-20,   Method: Composition-based stats.
 Identities = 31/185 (16%), Positives = 64/185 (34%), Gaps = 9/185 (4%)

Query: 127 IAKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAP------ 180
           +A       R+            + V     +      +++ +       +         
Sbjct: 571 LASISPERQRKVSAPPRMGTDAQVVVAIQNFHGIAPSGRSSLNMVIGDEGLSIRTGTTGY 630

Query: 181 PMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQA--LLKTEGDFLVRQSDH 238
             R   +    +   N +   ++       +  G + R +A+   + +++G FLVR+S +
Sbjct: 631 FPRSHVTSTENADAGNKQNQGLSIRTGTTGF-AGKMDRTEAEQETMGRSDGTFLVRESAN 689

Query: 239 TPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRE 298
             G+Y LS R         I  ++     T+ + F +I EL+ Y+  N + V   G D  
Sbjct: 690 RAGEYALSVRFRNATKHIKIPYEDGTFCLTQSKVFDSIPELVAYYRENTLGVSFTGLDTT 749

Query: 299 TSLNL 303
               L
Sbjct: 750 LRCGL 754


>UniRef50_C0H9A3 Tyrosine-protein phosphatase non-receptor type 6 n=11 Tax=Eumetazoa
           RepID=C0H9A3_SALSA
          Length = 582

 Score =  100 bits (248), Expect = 9e-20,   Method: Composition-based stats.
 Identities = 31/129 (24%), Positives = 57/129 (44%), Gaps = 17/129 (13%)

Query: 190 RQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL---KTEGDFLVRQSDHTPGKYVLS 246
           +   +   + P    D   + WYHG+LS  +A+ LL      G FLVR+S   PG +VLS
Sbjct: 89  KDGTIIELKYPFNCSDPTTERWYHGHLSGPNAEKLLWERDEPGTFLVRESLSKPGDFVLS 148

Query: 247 GRT--------AENEHKHLILLDNHNRVRTRDRT-FSNISELIDYHVNNGMAVRSEGRDR 297
             T              H+ ++  ++R     +  F  +++L++++   G+         
Sbjct: 149 VLTEEKSKASSGGRRVSHIKIMCQNDRYTVGGKEMFDTLADLMEHYKRKGI-----EEMS 203

Query: 298 ETSLNLIRP 306
            T ++L +P
Sbjct: 204 GTWVHLKQP 212



 Score = 90.6 bits (223), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 28/114 (24%), Positives = 50/114 (43%), Gaps = 10/114 (8%)

Query: 208 GKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
              W+H ++S  DA+++LK+    G FL R S    G + LS R  E    H+ + +  +
Sbjct: 1   MVRWFHRDISGLDAESVLKSRGVHGSFLARPSRKNQGDFSLSVRVGE-LVTHIRIQNTGD 59

Query: 265 RVRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC--PGSDDI 315
                    F+ +SEL++Y+      ++       T + L  P  C  P ++  
Sbjct: 60  FYDLYGGEKFATLSELVEYYTAENGILQD---KDGTIIELKYPFNCSDPTTERW 110


>UniRef50_B5X487 GRB2-related adaptor protein 2 n=1 Tax=Salmo salar
           RepID=B5X487_SALSA
          Length = 289

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 26/125 (20%), Positives = 54/125 (43%), Gaps = 3/125 (2%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLS 246
             +        P    +     W+    SR  A+ LL  +  G FL+R S  +PG++ +S
Sbjct: 36  KAELHGQEGFVPQNYIERQTPSWFKETASRSSAEELLMSREVGGFLIRGSQSSPGEFSIS 95

Query: 247 GRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRP 306
            R   +     ++ D+          F+++++L+D++ N  ++ + +   R+ S +   P
Sbjct: 96  VRHEFDVQHFKVMKDSKGHYFLWSEKFTSLNKLVDFYKNTSISKQRDIYLRDGSRDDQSP 155

Query: 307 -VPCP 310
             P P
Sbjct: 156 STPQP 160


>UniRef50_Q8T6F8 Protein tyrosine kinase n=5 Tax=Chromadorea RepID=Q8T6F8_CAEEL
          Length = 533

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 28/140 (20%), Positives = 52/140 (37%), Gaps = 23/140 (16%)

Query: 182 MRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK----TEGDFLVRQSD 237
           +RH+ +        N  A    + +  + WY G + R  A+ L+      +G FL+R+ +
Sbjct: 111 VRHQRTGQTGYVPRNFVA--KQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIRERE 168

Query: 238 HTPGKYVLSGRT-----AENEHKHLILL---DNHNRVRTRDRTFSNISELIDYHVNNGMA 289
               ++ L+ R           KH  +     +     T  RTF ++ EL+ Y+ +    
Sbjct: 169 ADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDG 228

Query: 290 VRSEGRDRETSLNLIRPVPC 309
           +            L  P P 
Sbjct: 229 LC---------CQLTFPAPR 239


>UniRef50_Q9Y1Y1 Protein tyrosine kinase (Fragment) n=1 Tax=Ephydatia fluviatilis
           RepID=Q9Y1Y1_9METZ
          Length = 893

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 31/171 (18%), Positives = 57/171 (33%), Gaps = 13/171 (7%)

Query: 139 HVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCR 198
           H +       +      A         A  + S+   +         +            
Sbjct: 462 HRMQSNTSQSIDSTEGEAGEPGEPGETATDAASSADPSAIVEDNESETGSTTDVPPET-- 519

Query: 199 APTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLI 258
                  V  + W++ N+ R++A+   K  GD+L+R S     +YVL+   A      +I
Sbjct: 520 ------RVEEERWFYPNMERKEAEEKCKNTGDYLIRYS-SKQNRYVLTVCWAGQGKHFVI 572

Query: 259 LLDNHNR----VRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
                 +     R   R+F ++ EL+D+HVN+   V        +   L  
Sbjct: 573 QEAPDEQTKTKYRFESRSFPSVRELLDFHVNSQTPVTKASGAILSRPILRE 623


>UniRef50_O97034 PLC-gammaS n=1 Tax=Ephydatia fluviatilis RepID=O97034_9METZ
          Length = 1283

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 33/139 (23%), Positives = 51/139 (36%), Gaps = 18/139 (12%)

Query: 185 RSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNL--SREDAQALLKT----EGDFLVRQSDH 238
           +         +N      TE  + + W+HG L   R  A+ LL       G FLVR+S  
Sbjct: 518 KDEDEADKTETNTETLPSTEQHLKEKWFHGKLAGGRVAAEKLLTDYKDVNGAFLVRESTT 577

Query: 239 TPGKYVLSGRTAENEHKHLILLD--NHNR---VRTRDRTFSNISELIDYHVNNGMAVRSE 293
             G Y LS    + ++ H  +       +          F +I ELI ++ +N +     
Sbjct: 578 FTGDYSLSF-VRDGKYNHCRIHTKSEGGKTRFYLIDQTLFDSIYELIMHYKSNPL----- 631

Query: 294 GRDRETSLNLIRPVPCPGS 312
            +       L  PVP   S
Sbjct: 632 -KSPTFEQVLAEPVPQQNS 649



 Score = 98.7 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 33/138 (23%), Positives = 59/138 (42%), Gaps = 21/138 (15%)

Query: 186 SSLHRQSFVSNCRAPTVTEDVV-GKVWYHGNLSREDAQALLKT---EGDFLVRQSD--HT 239
           + L   +F      P   ++   GK W+H NLSR +A+ +LK    +G FL+R S+    
Sbjct: 629 NPLKSPTFEQVLAEPVPQQNSHLGKAWFHENLSRSEAEEMLKKVRMDGAFLIRPSEQNTK 688

Query: 240 PGK--YVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDR 297
            G+  Y +S R         I +D   +       F +++EL+ Y+  N +  R      
Sbjct: 689 AGQKNYAISFRAEGKVKHCRIEVDESGQYCIGSAIFDSLTELVQYYEANPLYRR------ 742

Query: 298 ETSLNLIRPVPCPGSDDI 315
              + L   +    ++D+
Sbjct: 743 ---MRLKYAI----NEDL 753


>UniRef50_UPI0001926B11 PREDICTED: similar to non-receptor protein-tyrosine kinase CSK n=1
           Tax=Hydra magnipapillata RepID=UPI0001926B11
          Length = 471

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 15/112 (13%)

Query: 204 EDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRT---AENEHKHLI 258
            ++    W+ G ++RE A+ LL  +  G FLVR+S + PG Y L   +    +    + +
Sbjct: 25  YELDLANWFFGKITREKAEELLTPREVGLFLVRESTNFPGDYTLCVVSPQNNKKVEHYRV 84

Query: 259 LLDNHNRVRT-RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
           +  N NRV    D  F N+ ELI ++  +   +            L +P+  
Sbjct: 85  ISTNDNRVTVDEDAFFPNLIELIKHYERDADGLC---------TMLKKPLKK 127


>UniRef50_A8WVQ7 C. briggsae CBR-CSK-1 protein n=3 Tax=Caenorhabditis
           RepID=A8WVQ7_CAEBR
          Length = 536

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 21/90 (23%), Positives = 45/90 (50%), Gaps = 3/90 (3%)

Query: 207 VGKVWYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN 264
             + W+H  +SRE+ + LL+   +G FLVR+S + PG + L          + I   +  
Sbjct: 144 NNQPWFHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMAYHGKVEHYRIEQTSGG 203

Query: 265 RV-RTRDRTFSNISELIDYHVNNGMAVRSE 293
           ++   ++  FSN+++L+ ++  +   +   
Sbjct: 204 QLTCDKEEYFSNLTQLVSHYKRDADGLCHR 233


>UniRef50_Q8IR23 GH13542p n=21 Tax=Arthropoda RepID=Q8IR23_DROME
          Length = 954

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 33/123 (26%), Positives = 49/123 (39%), Gaps = 13/123 (10%)

Query: 191 QSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLK---TEGDFLVRQSDHTPGKYVLSG 247
              + N   P +        WYHG L R  A++ L+     G +LVR+SD  PG YVLS 
Sbjct: 65  GPHMLNGERPAIIAPPES-EWYHGRLDRYSAESRLRGSSKLGSYLVRESDRKPGSYVLSY 123

Query: 248 RTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPV 307
                   H  +           R F ++S+L+ Y+ +    ++ E         L  PV
Sbjct: 124 -YGRTGINHFRITAVCGDFYIGGRQFISLSDLVGYYTSCSDLLKRE--------RLAIPV 174

Query: 308 PCP 310
             P
Sbjct: 175 APP 177



 Score = 75.2 bits (183), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 3/83 (3%)

Query: 209 KVWYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRV 266
             W+H N ++ +A  +L     G FLVR SD++PG Y L      N+ +   +     R 
Sbjct: 251 FPWFHPNCTKNEAVDMLVKAGPGSFLVRPSDNSPGDYSL-FFHINNQIQRFRIEKKGVRY 309

Query: 267 RTRDRTFSNISELIDYHVNNGMA 289
               RTF  +  +I+ +    + 
Sbjct: 310 LMGGRTFECLDAVINRYRKEQIV 332


>UniRef50_Q4SW52 Chromosome undetermined SCAF13690, whole genome shotgun sequence.
           (Fragment) n=1 Tax=Tetraodon nigroviridis
           RepID=Q4SW52_TETNG
          Length = 338

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 29/101 (28%), Positives = 45/101 (44%), Gaps = 12/101 (11%)

Query: 211 WYHGNLSREDAQALLK--TEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           WY G + R +AQ  L+    G FLVR S   PG YVLS         ++I    + R + 
Sbjct: 14  WYFGPVLRPEAQNRLQGQKHGMFLVRDSSTCPGDYVLSVSENSKVSHYIITSLPNKRFKI 73

Query: 269 RDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
            DR F ++  L++++  + +           +  LI P P 
Sbjct: 74  GDREFEHLPALLEFYKYHYL----------DTTTLIEPAPR 104


>UniRef50_O00459 Phosphatidylinositol 3-kinase regulatory subunit beta n=134
           Tax=Euteleostomi RepID=P85B_HUMAN
          Length = 728

 Score = 99.8 bits (247), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 25/111 (22%), Positives = 48/111 (43%), Gaps = 7/111 (6%)

Query: 202 VTEDVVGKVWYHGNLSREDAQALLK--TEGDFLVRQ-SDHTPGKYVLSGRTAENEHKHLI 258
               +    WY G++SRE+    L+   +G FLVR  S    G+Y L+ R   N     +
Sbjct: 321 SPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKV 380

Query: 259 LLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
              + +   +   TF ++ +LI+++ +  +       + +    L+ PV  
Sbjct: 381 FHRDGHYGFSEPLTFCSVVDLINHYRHESL----AQYNAKLDTRLLYPVSK 427



 Score = 81.0 bits (198), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 22/109 (20%), Positives = 46/109 (42%), Gaps = 10/109 (9%)

Query: 204 EDVVGKVWYHGNLSREDAQALL--KTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLD 261
                + WY G ++R  A+ +L  K +G FL+R+S    G Y  S    + + KH ++  
Sbjct: 615 PHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRES-SQRGCYACSVVV-DGDTKHCVIYR 672

Query: 262 NHNRVRTRDRT--FSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVP 308
                   +    + ++ EL+ ++ +  +       +   ++ L  PV 
Sbjct: 673 TATGFGFAEPYNLYGSLKELVLHYQHASLV----QHNDALTVTLAHPVR 717


>UniRef50_UPI0001926486 PREDICTED: similar to protein tyrosine phosphatase, partial n=2
           Tax=Hydra magnipapillata RepID=UPI0001926486
          Length = 517

 Score = 99.5 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 23/110 (20%), Positives = 45/110 (40%), Gaps = 8/110 (7%)

Query: 211 WYHGNLSREDAQALLKT--EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRT 268
           W+H +L+   A+ LL    +G FLVR S+   G + +S +         I  D  + +  
Sbjct: 5   WFHSSLNGSQAEELLTPLADGSFLVRPSESKHGDFTISVKCNGKVTHIKIQNDGDSFLLI 64

Query: 269 RDR-TFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC--PGSDDI 315
                F  +  L+ ++ N   +++         + L+ PV    P ++  
Sbjct: 65  GSPDPFPTLESLVSHYRNTPNSIK---EKSGVFIELLYPVRSTDPTTERW 111



 Score = 99.1 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 29/121 (23%), Positives = 56/121 (46%), Gaps = 6/121 (4%)

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEG---DFLVRQSDHTPGKYVL 245
            +         P  + D   + WYHG++  ++A+ +L ++G    +LVR+S   PG++VL
Sbjct: 89  EKSGVFIELLYPVRSTDPTTERWYHGSIGAKEAERMLLSKGRLGSYLVRESQSQPGQFVL 148

Query: 246 SGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIR 305
             + A    + +I   N         +F+++ ELI+Y+V N           ++ + L  
Sbjct: 149 VVKCANGVQQVIISCRNKKYEIKSGPSFASLQELIEYYVMNPKL---HDVKDQSPIKLRE 205

Query: 306 P 306
           P
Sbjct: 206 P 206


>UniRef50_Q9UN19 Dual adapter for phosphotyrosine and 3-phosphotyrosine and
           3-phosphoinositide n=25 Tax=Chordata RepID=DAPP1_HUMAN
          Length = 280

 Score = 99.5 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 32/113 (28%), Positives = 53/113 (46%), Gaps = 8/113 (7%)

Query: 204 EDVVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILL 260
           E +    WYHGNL+R  A+ALL +   +G +L+R S+ T G Y LS R  ++  KH  + 
Sbjct: 28  ELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSV-KHFHVE 86

Query: 261 DNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
                 +     FS++ + + +  N  +     G +  T + L  P P    +
Sbjct: 87  YTGYSFKFGFNEFSSLKDFVKHFANQPLI----GSETGTLMVLKHPYPRKVEE 135


>UniRef50_P19174 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
           n=83 Tax=Eumetazoa RepID=PLCG1_HUMAN
          Length = 1290

 Score = 99.5 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 32/145 (22%), Positives = 52/145 (35%), Gaps = 25/145 (17%)

Query: 183 RHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLS-----REDAQALLK--------TEG 229
              S    +         + TE    + W+HG L      R  A+ LL          +G
Sbjct: 522 ETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDG 581

Query: 230 DFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHN-----RVRTRDRTFSNISELIDYHV 284
            FLVR+S+   G Y LS      + +H  +    +        T +  F ++ +LI ++ 
Sbjct: 582 SFLVRESETFVGDYTLSF-WRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQ 640

Query: 285 NNGMAVRSEGRDRETSLNLIRPVPC 309
              +      R  E  + L  PVP 
Sbjct: 641 QVPL------RCNEFEMRLSEPVPQ 659



 Score = 94.4 bits (233), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 34/176 (19%), Positives = 61/176 (34%), Gaps = 18/176 (10%)

Query: 146 VHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTED 205
            +  +         +         T N  F      + H   +  +      R       
Sbjct: 601 RNGKVQHCRIHSRQDA-GTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQ 659

Query: 206 ---VVGKVWYHGNLSREDAQALLKT---EGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL 259
                 K WYH +L+R  A+ +L     +G FLVR+  + P  Y +S R AE + KH  +
Sbjct: 660 TNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKR-NEPNSYAISFR-AEGKIKHCRV 717

Query: 260 LDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSDDI 315
                 V   +  F ++ +LI Y+  + +  +         + L  P+     + I
Sbjct: 718 QQEGQTVMLGNSEFDSLVDLISYYEKHPLYRK---------MKLRYPINEEALEKI 764


>UniRef50_UPI00016E9A03 UPI00016E9A03 related cluster n=1 Tax=Takifugu rubripes
           RepID=UPI00016E9A03
          Length = 489

 Score = 99.5 bits (246), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 31/139 (22%), Positives = 54/139 (38%), Gaps = 14/139 (10%)

Query: 166 ANASTSNDGFTVPAPPMRHRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALL 225
            + S   D   +P+PP     S  R S   + +A           W+HG +SR  A  L+
Sbjct: 345 RSRSGGADLEPLPSPPDVSAPSSQRGSTELSSQA---------YPWFHGPISRVKAAYLV 395

Query: 226 KT-----EGDFLVRQSDHTPGKYVLSGRTAENEHKHLILLDNHNRVRTRDRTFSNISELI 280
           ++      G FLVRQS+   G YVL+           + L    + R +   F ++ +++
Sbjct: 396 QSSGPEGHGVFLVRQSETRRGDYVLTFNYQGKAKHLRLSLTEWGQCRVQHLRFPSVMDML 455

Query: 281 DYHVNNGMAVRSEGRDRET 299
            +     + +        T
Sbjct: 456 SHFRLFPIPLECGAAGAVT 474


>UniRef50_UPI000180BDCA PREDICTED: similar to Src homology 2 domain containing adaptor
           protein B n=1 Tax=Ciona intestinalis RepID=UPI000180BDCA
          Length = 627

 Score = 99.5 bits (246), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 37/243 (15%), Positives = 82/243 (33%), Gaps = 18/243 (7%)

Query: 70  RVIGEVKKENFPVDINISSKMIKIIKQS-RLIQRHPFSFFSFGAQGQKGTDTELMFGYIA 128
           R  G + K +    +  S+++     +S   +  +   +          T  +    +I+
Sbjct: 393 RGDGGIPKSSSDDHLVQSAQVTVPTNKSLDGVSEYEEPW-------DTETTLKHGNPHIS 445

Query: 129 KNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSSL 188
            ++  +     V  +    K           +        S               +  L
Sbjct: 446 HSRSRSYEISSVPQLNRHSKSHSFDNQDPGDDYEHPWDKPSIPKVHLESMQRFQHRQLEL 505

Query: 189 HRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE--GDFLVRQSDHTPGKYVLS 246
           H    +++         +  + WYHG ++R++A   L  E  G +LVR S+ T   Y LS
Sbjct: 506 HPSEAIADKDF-DPLLPLTKQGWYHGAITRDEANMRLSREVPGSYLVRNSESTANNYSLS 564

Query: 247 GRTAENEHKHLILLDNHNRVRTRD--RTFSNISELIDYHVNNGMAVRSEGRDRETSLNLI 304
            RT       +I           +    F ++ E+I ++  + + +     +   +++L 
Sbjct: 565 LRTRSTTIHMVISSTRDGFWILGEFSAPFHSVPEMIAFYSTHRLKI-----NDTQNISLK 619

Query: 305 RPV 307
            P+
Sbjct: 620 YPI 622


>UniRef50_UPI00006A1C30 UPI00006A1C30 related cluster n=1 Tax=Xenopus (Silurana) tropicalis
           RepID=UPI00006A1C30
          Length = 514

 Score = 99.5 bits (246), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 36/114 (31%), Positives = 49/114 (42%), Gaps = 14/114 (12%)

Query: 205 DVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPGKYVLSGRTAENEHKHLIL----- 259
           D+    WYHG L R+DA+ LL + GDFL+R S  +PG YVLS   A  +  H  +     
Sbjct: 22  DLRSHAWYHGPLPRQDAERLLVSNGDFLIRDSISSPGDYVLSCFCAGGQPLHFKIIAVAL 81

Query: 260 LDNHN----RVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPC 309
                      +     F NI  L+  +V +   V        T   +IRPV  
Sbjct: 82  RPRRGIARTLYQLEQDQFDNIPALVRSYVGDRRKVSES-----TGAVIIRPVNR 130


>UniRef50_B6DS94 Src family kinase n=1 Tax=Strongylocentrotus purpuratus
           RepID=B6DS94_STRPU
          Length = 501

 Score = 99.1 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 26/140 (18%), Positives = 52/140 (37%), Gaps = 23/140 (16%)

Query: 184 HRSSLHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTE----GDFLVRQSDHT 239
              +  +     N  AP  +  +  + W+ G+ +R +A   L+ +    G FLVR+S+  
Sbjct: 88  STRTNVQGYIPCNYVAPVNS--LEVEGWFFGSCTRSEAIMRLQADNLPKGTFLVRESETR 145

Query: 240 PGKYVLSGR-----TAENEHKHLILLDNHN---RVRTRDRTFSNISELIDYHVNNGMAVR 291
           PG Y L+ R            + +               R F+ + +++ +H +    + 
Sbjct: 146 PGTYALTVRETDHGHPPTIKNYRVDKTKDGSELFFINPQRKFNTVIDVVKFHTSQPGGLC 205

Query: 292 SEGRDRETSLNLIRPVPCPG 311
           S          L++P P   
Sbjct: 206 S---------KLLKPCPKQT 216


>UniRef50_A8XFT2 Putative uncharacterized protein n=4 Tax=Caenorhabditis briggsae
           RepID=A8XFT2_CAEBR
          Length = 577

 Score = 99.1 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 29/119 (24%), Positives = 57/119 (47%), Gaps = 15/119 (12%)

Query: 203 TEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSDHTPG---KYVLSGRTAE-----NEH 254
            +D+  + WYHG L RED +A+L+  GDFL+R ++   G   +YVLS    E        
Sbjct: 3   DKDIHTEPWYHGLLPREDIKAMLRKTGDFLIRSTEPKQGEARQYVLSAMQNEELEDAGVK 62

Query: 255 KHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLNLIRPVPCPGSD 313
            +++ ++ +N++    + F  I+ L++Y++     ++           L  P+     +
Sbjct: 63  HYVMRVNANNQIFLETKGFETITSLVNYYMTTKDPIKK-------MTVLKTPIVKQDWE 114


>UniRef50_O01325 Protein F26E4.5, confirmed by transcript evidence n=3
           Tax=Caenorhabditis RepID=O01325_CAEEL
          Length = 474

 Score = 99.1 bits (245), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 35/177 (19%), Positives = 76/177 (42%), Gaps = 3/177 (1%)

Query: 128 AKNKDGTDRRCHVVFIEDVHKLIDVLTTAINVNTFDAQANASTSNDGFTVPAPPMRHRSS 187
            ++KD ++    V   + + K  D  ++     +       S  N   +     ++    
Sbjct: 9   RRHKDRSEVETAVRGPDLLLKATDETSSDGASTSLSKSVEESAPNKDKSNS-SLVKSHHV 67

Query: 188 LHRQSFVSNCRAPTVTEDVVGKVWYHGNLSREDAQALLKTEGDFLVRQSD-HTPGKYV-L 245
           L  +       +      +  + +YHG +SRE+++ L++++G+FL+R+++    G+ V L
Sbjct: 68  LKIKLKKITNWSGCSGALLDDEPFYHGYMSREESEKLVRSQGEFLLRKTELTKRGEVVVL 127

Query: 246 SGRTAENEHKHLILLDNHNRVRTRDRTFSNISELIDYHVNNGMAVRSEGRDRETSLN 302
           S    E  H  ++   N+     ++  F NIS+L+ YH     +V   G    + + 
Sbjct: 128 SVFWDEGVHHLVVEKANNGLYYLKEFCFENISDLVRYHHQTRASVYKSGIKLFSWVV 184


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.309    0.126    0.338 

Lambda     K      H
   0.267   0.0390    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,595,886,637
Number of Sequences: 3077464
Number of extensions: 62313217
Number of successful extensions: 183000
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 945
Number of HSP's successfully gapped in prelim test: 1207
Number of HSP's that attempted gapping in prelim test: 178487
Number of HSP's gapped (non-prelim): 2726
length of query: 316
length of database: 1,040,396,356
effective HSP length: 128
effective length of query: 188
effective length of database: 646,480,964
effective search space: 121538421232
effective search space used: 121538421232
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.2 bits)
S2: 93 (40.5 bits)
