Phyre 2 Results for Q9TYT3

Phyre Home | Retrieve Phyre Job Id

Email | l.a.kelley@imperial.ac.uk
Description | Q9TYT3
Date | Sat Apr 13 13:01:24 BST 2013
Unique Job ID | 2b16cb7caa7c6c32

Summary |

Top model
Image coloured by rainbow N → C terminus
Model dimensions (Å): | X:52.228 Y:43.781 Z:37.032
| Close Jmol

Model (left) based on template d1oy2a_
Top template information
Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
Confidence and coverage
Confidence: | 100.0% | Coverage: | 50%
159 residues ( 50% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
282 residues ( 89%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | L | N | V | E | P | S | F | A | E | E | L | R | S | S | G | V | S | L | S | A | T | Y | L | G | S | V | P | V | V | E | S | I | N | V | M | V | S | E | M | R | V | Q | V | V | S | E | C | I | Q | H | V | A | A | T | V | G | V | T | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | A | R | E | I | N | P | V | V | S | R | V | I | G | E | V | K | K | E | N | F | P | V | D | I | N | I | S | S | K | M | I | K | I | I | K | Q | S | R | L | I | Q | R | H | P | F | S | F | F | S | F | G | A | Q | G | Q | K | G | T | D | T
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? |  | ? |  | ? | ? | ? |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  | ? | ? |  | ? | ? |  |  | ? |  | ? |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | E | L | M | F | G | Y | I | A | K | N | K | D | G | T | D | R | R | C | H | V | V | F | I | E | D | V | H | K | L | I | D | V | L | T | T | A | I | N | V | N | T | F | D | A | Q | A | N | A | S | T | S | N | D | G | F | T | V | P | A | P
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  | ? | ? | ? | ? | ? | ? |  | ? | ? |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | P | M | R | H | R | S | S | L | H | R | Q | S | F | V | S | N | C | R | A | P | T | V | T | E | D | V | V | G | K | V | W | Y | H | G | N | L | S | R | E | D | A | Q | A | L | L | K | T | E | G | D | F | L | V | R | Q | S | D | H | T | P
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300
Sequence |  | G | K | Y | V | L | S | G | R | T | A | E | N | E | H | K | H | L | I | L | L | D | N | H | N | R | V | R | T | R | D | R | T | F | S | N | I | S | E | L | I | D | Y | H | V | N | N | G | M | A | V | R | S | E | G | R | D | R | E | T | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? | ? | ? | ? | ? | ? |  | ? | ? |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | .
Sequence |  | L | N | L | I | R | P | V | P | C | P | G | S | D | D | I | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)
? | Disordered ( 37%)
| Alpha helix ( 28%)
| Beta strand ( 15%)

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| d1oy2a_ |

### PDB 1oy2 chain A

Region: 7 - 171
Aligned: 159
Modelled: 165
Confidence: 100.0%
Identity: 21%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Phosphotyrosine-binding domain (PTB)

Phyre2
2 |
| c3suzA_ |

### PDB 3suz chain A

Region: 8 - 174
Aligned: 153
Modelled: 167
Confidence: 100.0%
Identity: 22%
PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family a member
PDBTitle: crystal structure of rat mint2 ppc

Phyre2
3 |
| c3sv1C_ |

### PDB 3sv1 chain C

Region: 8 - 163
Aligned: 137
Modelled: 156
Confidence: 100.0%
Identity: 23%
PDB header:protein binding
Chain: C: PDB Molecule:amyloid beta a4 precursor protein-binding family a member
PDBTitle: crystal structure of app peptide bound rat mint2 parm

Phyre2
4 |
| d1p3ra_ |

### PDB 1p3r chain A

Region: 1 - 169
Aligned: 143
Modelled: 154
Confidence: 100.0%
Identity: 17%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Phosphotyrosine-binding domain (PTB)

Phyre2
5 |
| c3d8dA_ |

### PDB 3d8d chain A

Region: 15 - 163
Aligned: 134
Modelled: 140
Confidence: 100.0%
Identity: 17%
PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member
PDBTitle: crystal structure of the human fe65-ptb1 domain

Phyre2
6 |
| c2m38A_ |

### PDB 2m38 chain A

Region: 10 - 167
Aligned: 133
Modelled: 145
Confidence: 100.0%
Identity: 22%
PDB header:peptide binding protein
Chain: A: PDB Molecule:ankyrin repeat and sterile alpha motif domain-containing
PDBTitle: ptb domain of aida1

Phyre2
7 |
| d1wj1a_ |

### PDB 1wj1 chain A

Region: 7 - 177
Aligned: 138
Modelled: 151
Confidence: 100.0%
Identity: 22%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Phosphotyrosine-binding domain (PTB)

Phyre2
8 |
| d1ntva_ |

### PDB 1ntv chain A

Region: 4 - 172
Aligned: 143
Modelled: 154
Confidence: 100.0%
Identity: 16%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Phosphotyrosine-binding domain (PTB)

Phyre2
9 |
| d1aqca_ |

### PDB 1aqc chain A

Region: 10 - 164
Aligned: 125
Modelled: 141
Confidence: 100.0%
Identity: 25%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Phosphotyrosine-binding domain (PTB)

Phyre2
10 |
| c3so6A_ |

### PDB 3so6 chain A

Region: 16 - 172
Aligned: 129
Modelled: 141
Confidence: 100.0%
Identity: 20%
PDB header:protein binding/protein transport
Chain: A: PDB Molecule:ldl receptor adaptor protein;
PDBTitle: crystal structure of the ldl receptor tail in complex with autosomal2 recessive hypercholesterolemia ptb domain

Phyre2
11 |
| d2dkqa1 |

### PDB 2dkq chain A domain 1

Region: 6 - 158
Aligned: 128
Modelled: 135
Confidence: 100.0%
Identity: 25%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Phosphotyrosine-binding domain (PTB)

Phyre2
12 |
| c2yszA_ |

### PDB 2ysz chain A

Region: 6 - 186
Aligned: 143
Modelled: 163
Confidence: 100.0%
Identity: 18%
PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family
PDBTitle: solution structure of the chimera of the c-terminal pid2 domain of fe65l and the c-terminal tail peptide of app

Phyre2
13 |
| c2elaB_ |

### PDB 2ela chain B

Region: 18 - 172
Aligned: 129
Modelled: 137
Confidence: 99.9%
Identity: 16%
PDB header:cell cycle
Chain: B: PDB Molecule:adapter protein containing ph domain, ptb domain
PDBTitle: crystal structure of the ptb domain of human appl1

Phyre2
14 |
| c2gsbA_ |

### PDB 2gsb chain A

Region: 195 - 313
Aligned: 110
Modelled: 119
Confidence: 99.9%
Identity: 34%
PDB header:signaling protein
Chain: A: PDB Molecule:ras gtpase-activating protein 1;
PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1

Phyre2
15 |
| c2dcrA_ |

### PDB 2dcr chain A

Region: 194 - 312
Aligned: 112
Modelled: 119
Confidence: 99.9%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps;
PDBTitle: fully automated solution structure determination of the fes2 sh2 domain

Phyre2
16 |
| c2hdxB_ |

### PDB 2hdx chain B

Region: 204 - 308
Aligned: 99
Modelled: 105
Confidence: 99.9%
Identity: 28%
PDB header:signaling protein
Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1
PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide

Phyre2
17 |
| c3dxeC_ |

### PDB 3dxe chain C

Region: 13 - 174
Aligned: 128
Modelled: 144
Confidence: 99.9%
Identity: 19%
PDB header:protein binding
Chain: C: PDB Molecule:amyloid beta a4 protein-binding family b member
PDBTitle: crystal structure of the intracellular domain of human app2 (t668a mutant) in complex with fe65-ptb2

Phyre2
18 |
| c2yt1A_ |

### PDB 2yt1 chain A

Region: 14 - 156
Aligned: 113
Modelled: 125
Confidence: 99.9%
Identity: 19%
PDB header:protein binding
Chain: A: PDB Molecule:amyloid beta a4 protein and amyloid beta a4
PDBTitle: solution structure of the chimera of the c-terminal tail2 peptide of app and the c-terminal pid domain of fe65l

Phyre2
19 |
| c2kk6A_ |

### PDB 2kk6 chain A

Region: 200 - 310
Aligned: 105
Modelled: 111
Confidence: 99.9%
Identity: 36%
PDB header:transferase
Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer;
PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d

Phyre2
20 |
| d1ddma_ |

### PDB 1ddm chain A

Region: 9 - 161
Aligned: 123
Modelled: 130
Confidence: 99.9%
Identity: 28%
Fold: PH domain-like barrel
Superfamily: PH domain-like
Family: Phosphotyrosine-binding domain (PTB)

Phyre2
21 |
22 |
| d1mila_ |

### PDB 1mil chain A

Region: 205 - 309
Aligned: 100
Modelled: 100
Confidence: 99.9%
Identity: 47%
Fold: SH2-like
Superfamily: SH2 domain
Family: SH2 domain

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | d1oy2a_ |
|  | 100.0 | 21 | Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
2 | c3suzA_ |
|  | 100.0 | 22 | PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family a member PDBTitle: crystal structure of rat mint2 ppc
3 | c3sv1C_ |
|  | 100.0 | 23 | PDB header:protein binding Chain: C: PDB Molecule:amyloid beta a4 precursor protein-binding family a member PDBTitle: crystal structure of app peptide bound rat mint2 parm
4 | d1p3ra_ |
|  | 100.0 | 17 | Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
5 | c3d8dA_ |
|  | 100.0 | 17 | PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member PDBTitle: crystal structure of the human fe65-ptb1 domain
6 | c2m38A_ |
|  | 100.0 | 22 | PDB header:peptide binding protein Chain: A: PDB Molecule:ankyrin repeat and sterile alpha motif domain-containing PDBTitle: ptb domain of aida1
7 | d1wj1a_ |
|  | 100.0 | 22 | Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
8 | d1ntva_ |
|  | 100.0 | 16 | Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
9 | d1aqca_ |
|  | 100.0 | 25 | Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
10 | c3so6A_ |
|  | 100.0 | 20 | PDB header:protein binding/protein transport Chain: A: PDB Molecule:ldl receptor adaptor protein; PDBTitle: crystal structure of the ldl receptor tail in complex with autosomal2 recessive hypercholesterolemia ptb domain
11 | d2dkqa1 |
|  | 100.0 | 25 | Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
12 | c2yszA_ |
|  | 100.0 | 18 | PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family PDBTitle: solution structure of the chimera of the c-terminal pid2 domain of fe65l and the c-terminal tail peptide of app
13 | c2elaB_ |
|  | 99.9 | 16 | PDB header:cell cycle Chain: B: PDB Molecule:adapter protein containing ph domain, ptb domain PDBTitle: crystal structure of the ptb domain of human appl1
14 | c2gsbA_ |
|  | 99.9 | 34 | PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1
15 | c2dcrA_ |
|  | 99.9 | 29 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain
16 | c2hdxB_ |
|  | 99.9 | 28 | PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide
17 | c3dxeC_ |
|  | 99.9 | 19 | PDB header:protein binding Chain: C: PDB Molecule:amyloid beta a4 protein-binding family b member PDBTitle: crystal structure of the intracellular domain of human app2 (t668a mutant) in complex with fe65-ptb2
18 | c2yt1A_ |
|  | 99.9 | 19 | PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 protein and amyloid beta a4 PDBTitle: solution structure of the chimera of the c-terminal tail2 peptide of app and the c-terminal pid domain of fe65l
19 | c2kk6A_ |
|  | 99.9 | 36 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d
20 | d1ddma_ |
|  | 99.9 | 28 | Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
21 | c2eo6A_ |
| not modelled | 99.9 | 22 | PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk
22 | d1mila_ |
|  | 99.9 | 47 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
23 | c2dlzA_ |
| not modelled | 99.9 | 19 | PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2
24 | c2eo3A_ |
| not modelled | 99.9 | 28 | PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein
25 | c2dyqA_ |
| not modelled | 99.9 | 22 | PDB header:protein binding Chain: A: PDB Molecule:amyloid beta a4 precursor protein-binding family b member PDBTitle: crystal structure of the c-terminal phophotyrosine interaction domain2 of human apbb3
26 | d2cy5a1 |
| not modelled | 99.9 | 11 | Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
27 | c2dlyA_ |
| not modelled | 99.9 | 22 | PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase
28 | d3c7ia1 |
| not modelled | 99.9 | 27 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
29 | c2lqnA_ |
| not modelled | 99.9 | 28 | PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl
30 | d2oq1a1 |
| not modelled | 99.9 | 24 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
31 | c2b3oA_ |
| not modelled | 99.9 | 29 | PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1
32 | d1wgua_ |
| not modelled | 99.9 | 22 | Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
33 | d2shpa2 |
| not modelled | 99.9 | 25 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
34 | c2oq1A_ |
| not modelled | 99.9 | 24 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide
35 | d1fhsa_ |
| not modelled | 99.9 | 26 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
36 | d1wvha1 |
| not modelled | 99.9 | 20 | Fold:PH domain-like barrel Superfamily:PH domain-like Family:Phosphotyrosine-binding domain (PTB)
37 | c1ka6A_ |
| not modelled | 99.9 | 27 | PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py
38 | c3hizB_ |
| not modelled | 99.9 | 28 | PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha
39 | c1x6cA_ |
| not modelled | 99.9 | 27 | PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1
40 | c2eobA_ |
| not modelled | 99.9 | 26 | PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2
41 | c2crhA_ |
| not modelled | 99.9 | 22 | PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1
42 | d1rjaa_ |
| not modelled | 99.9 | 28 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
43 | d1opka2 |
| not modelled | 99.9 | 28 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
44 | c2ci8A_ |
| not modelled | 99.9 | 27 | PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed
45 | d1blja_ |
| not modelled | 99.9 | 25 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
46 | c2shpA_ |
| not modelled | 99.9 | 25 | PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2
47 | c2fo0A_ |
| not modelled | 99.9 | 30 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase
48 | d1a81e1 |
| not modelled | 99.9 | 24 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
49 | d1a81e2 |
| not modelled | 99.9 | 24 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
50 | d1d4ta_ |
| not modelled | 99.9 | 25 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
51 | d2izva2 |
| not modelled | 99.9 | 24 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
52 | d1jwoa_ |
| not modelled | 99.9 | 25 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
53 | d1a81a1 |
| not modelled | 99.9 | 27 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
54 | d1pica_ |
| not modelled | 99.9 | 22 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
55 | d1ayaa_ |
| not modelled | 99.9 | 24 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
56 | c3gqiB_ |
| not modelled | 99.9 | 28 | PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates
57 | c2y3aB_ |
| not modelled | 99.9 | 22 | PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941
58 | c2ablA_ |
| not modelled | 99.9 | 29 | PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase
59 | d2oq1a2 |
| not modelled | 99.9 | 27 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
60 | d1csya_ |
| not modelled | 99.9 | 24 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
61 | d1nrva_ |
| not modelled | 99.9 | 23 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
62 | c2ozoA_ |
| not modelled | 99.9 | 23 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70
63 | c2lctA_ |
| not modelled | 99.9 | 21 | PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide
64 | c2ysxA_ |
| not modelled | 99.9 | 29 | PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain
65 | d1a81a2 |
| not modelled | 99.9 | 22 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
66 | d1k9aa2 |
| not modelled | 99.9 | 29 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
67 | c2ge9A_ |
| not modelled | 99.9 | 28 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase
68 | c2augB_ |
| not modelled | 99.9 | 24 | PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain
69 | d1r1qa_ |
| not modelled | 99.9 | 26 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
70 | c1oplA_ |
| not modelled | 99.9 | 30 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase
71 | c2hmhA_ |
| not modelled | 99.9 | 19 | PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide.
72 | d2cs0a1 |
| not modelled | 99.9 | 26 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
73 | c1k9aB_ |
| not modelled | 99.9 | 28 | PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution
74 | c4fl2A_ |
| not modelled | 99.9 | 26 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch
75 | c3ps5A_ |
| not modelled | 99.9 | 28 | PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1
76 | d1bkla_ |
| not modelled | 99.9 | 29 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
77 | d2qmsa1 |
| not modelled | 99.9 | 28 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
78 | d1f2fa_ |
| not modelled | 99.9 | 29 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
79 | d1jyra_ |
| not modelled | 99.9 | 25 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
80 | d2eyva1 |
| not modelled | 99.9 | 36 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
81 | d1lkka_ |
| not modelled | 99.9 | 33 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
82 | d2fcia1 |
| not modelled | 99.9 | 30 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
83 | d1i3za_ |
| not modelled | 99.9 | 28 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
84 | c2vifA_ |
| not modelled | 99.9 | 24 | PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide
85 | d1fu6a_ |
| not modelled | 99.9 | 28 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
86 | c1y57A_ |
| not modelled | 99.9 | 22 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor
87 | d2shpa3 |
| not modelled | 99.9 | 36 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
88 | d1o48a_ |
| not modelled | 99.9 | 28 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
89 | c1a81E_ |
| not modelled | 99.9 | 21 | PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam
90 | c2c9wA_ |
| not modelled | 99.9 | 27 | PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution
91 | d1qcfa2 |
| not modelled | 99.9 | 27 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
92 | d1g83a2 |
| not modelled | 99.9 | 29 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
93 | c1x27F_ |
| not modelled | 99.9 | 31 | PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas
94 | c2dm0A_ |
| not modelled | 99.9 | 30 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk
95 | d1xa6a2 |
| not modelled | 99.9 | 25 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
96 | c2izvA_ |
| not modelled | 99.9 | 21 | PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution
97 | d1qada_ |
| not modelled | 99.9 | 24 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
98 | c3nhnA_ |
| not modelled | 99.9 | 26 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region
99 | c2knoA_ |
| not modelled | 99.9 | 31 | PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1)
100 | d1luia_ |
| not modelled | 99.9 | 35 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
101 | c2h8hA_ |
| not modelled | 99.9 | 27 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor
102 | c2c0iA_ |
| not modelled | 99.9 | 24 | PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983
103 | c2ekxA_ |
| not modelled | 99.9 | 30 | PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain
104 | d2c9wa2 |
| not modelled | 99.9 | 27 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
105 | c1rqqC_ |
| not modelled | 99.8 | 26 | PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps
106 | d1rpya_ |
| not modelled | 99.8 | 27 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
107 | c3mazA_ |
| not modelled | 99.8 | 20 | PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide
108 | c2el8A_ |
| not modelled | 99.8 | 17 | PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain
109 | c3gxxB_ |
| not modelled | 99.8 | 16 | PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b
110 | c1g83A_ |
| not modelled | 99.8 | 29 | PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2
111 | c2eyzA_ |
| not modelled | 99.8 | 32 | PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii
112 | c2cr4A_ |
| not modelled | 99.8 | 18 | PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein
113 | c2dvjA_ |
| not modelled | 99.8 | 30 | PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii
114 | d1cwea_ |
| not modelled | 99.8 | 34 | Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain
115 | c3qwyA_ |
| not modelled | 99.8 | 29 | PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2
116 | c3qwxX_ |
| not modelled | 99.8 | 29 | PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174
117 | c2eyyA_ |
| not modelled | 99.8 | 26 | PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i
118 | c2xp1A_ |
| not modelled | 99.8 | 20 | PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6
119 | c2dx0B_ |
| not modelled | 99.7 | 37 | PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2
120 | c3or8A_ |
| not modelled | 99.7 | 18 | PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6

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