Job Description O05204 Confidence 100.00% Date Tue Jul 17 17:05:01 BST 2012 Rank 3 Aligned Residues 376 % Identity 15% Template c1gthD_ PDB info PDB header:oxidoreductase Chain: D: PDB Molecule:dihydropyrimidine dehydrogenase; PDBTitle: dihydropyrimidine dehydrogenase (dpd) from pig, ternary2 complex with nadph and 5-iodouracil Resolution 2.25 Å

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		78	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.				130	.	.	.	.	.	.	.	.	.	140			.	.	.	.	.	.	.	.	.	150	.	.
Predicted Secondary structure																																																						.	.	.												.	.
Query SS confidence																																																						.	.	.												.	.
Query Sequence		G	I	P	L	G	H	E	F	N	S	L	V	L	A	I	L	Q	V	S	G	R	A	P	K	E	K	Q	S	I	I	D	Q	I	K	K	L	E	G	S	F	H	F	E	T	F	I	S	L	T	C	Q	K	.	.	.	C	P	D	V	V	Q	A	L	N	L	M	.	.	S	V	I	N	P	N	I	T	H	S	M	I
Query Conservation																																																						.	.	.												.	.
Alig confidence																		.	.	.	.	.	.	.	.	.																												.	.	.												.	.
Template Conservation																		.	.	.	.	.	.	.	.	.
Template Sequence		S	C	P	T	H	L	D	I	K	S	F	I	T	S	I	S	.	.	.	.	.	.	.	.	.	N	K	N	Y	Y	G	A	A	K	M	I	F	S	D	N	P	L	G	L	T	C	G	M	V	C	P	T	S	D	L	C	V	G	G	C	N	L	Y	A	T	E	E	G	S	I	N	I	G	G	L	Q	Q	F	A	S
Template Known Secondary structure		T	S	T	T													.	.	.	.	.	.	.	.	.	T	T														T	T										G	G	G	S	G	G	G	G		G	G	G	G	S	T	T
Template Predicted Secondary structure																		.	.	.	.	.	.	.	.	.
Template SS confidence
		90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.										.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160
		153	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230		.
Predicted Secondary structure																																																																																.
Query SS confidence																																																																																.
Query Sequence		D	G	A	V	F	R	E	E	S	E	N	I	M	A	V	P	A	V	F	L	N	G	E	E	F	G	N	G	R	M	T	I	Q	D	I	L	S	K	L	G	S	T	A	D	A	S	E	F	E	N	K	E	P	Y	D	V	L	I	V	G	G	G	P	A	S	G	S	A	A	I	Y	T	A	R	K	G	L	R	.	T
Query Conservation																																																																																.
Alig confidence																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																.
Template Conservation																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		E	V	F	K	A	M	N	I	P	Q	I	R	N	P	C	L	P	S	Q	E	K	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	M	P	E	A	Y	S	A	K	I	A	L	L	G	A	G	P	A	S	I	S	C	A	S	F	L	A	R	L	G	Y	S	D	I
Template Known Secondary structure								T				B			T	T	S			G	G	G	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	S		G	G	G	G									S														T
Template Predicted Secondary structure																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		161	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.																											.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.
		232	.	.	.	.	.			.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.
Predicted Secondary structure								.	.
Query SS confidence								.	.
Query Sequence		G	I	V	A	D	R	.	.	I	G	G	Q	V	N	D	T	A	G	I	E	N	F	I	T	V	K	E	T	T	G	S	E	F	S	S	N	L	A	A	H	I	D	Q	Y	D	I	D	A	M	T	G	I	R	A	T	D	I	E	K	T	D	E	A	I	K	V	T	L	E	N	G	A	V	L	E	S	K	T	V	I
Query Conservation								.	.
Alig confidence								.	.							.	.	.	.	.									.	.																										.	.	.	.	.	.	.
Template Conservation																.	.	.	.	.									.	.																										.	.	.	.	.	.	.
Template Sequence		T	I	F	E	K	Q	E	Y	V	G	G	L	S	T	.	.	.	.	.	S	E	I	P	Q	F	R	L	.	.	P	Y	D	V	V	N	F	E	I	E	L	M	K	D	L	G	V	K	I	I	C	G	K	S	L	.	.	.	.	.	.	.	S	E	N	E	I	T	L	N	T	L	K	E	E	G	Y	K	A	A	F
Template Known Secondary structure						S	S	S	S		S	T				.	.	.	.	.		T	S		T	T	T	S	.	.														T	T	T						S			B	.	.	.	.	.	.	.	S	T	T	S	B								T	T
Template Predicted Secondary structure																.	.	.	.	.									.	.																										.	.	.	.	.	.	.
Template SS confidence
		215	.	.	.	.	220	.	.	.	.	.	.	.	.						.	230	.	.	.	.	.	.			.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.								.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
		310	.	.	.	.	.		.	.	.	.	320	.	.	.	.	.	.	.																.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.		.	370	.	.
Predicted Secondary structure								.													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																										.
Query SS confidence								.													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																										.
Query Sequence		I	A	T	G	A	G	.	W	R	K	L	N	I	P	G	E	E	Q	L	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	I	N	K	G	V	A	F	C	P	H	C	D	G	P	L	F	E	N	K	D	V	A	V	I	G	G	G	N	S	G	V	E	A	A	I	D	L	A	G	I	V	.	N	H	V	T
Query Conservation								.													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																										.
Alig confidence								.													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																																										.
Template Conservation
Template Sequence		I	G	I	G	L	P	E	P	K	T	D	D	I	F	Q	G	L	T	Q	D	Q	G	F	Y	T	S	K	D	F	L	P	L	V	A	K	S	S	K	A	G	M	C	A	C	H	S	P	L	P	S	I	R	G	A	V	I	V	L	G	A	G	D	T	A	F	D	C	A	T	S	A	L	R	C	G	A	R	R	V	F
Template Known Secondary structure													G	G	G	T	T			T	T	T	T																	T	T	T		S	S									S								S													T	T		S
Template Predicted Secondary structure
Template SS confidence
		281	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
		373	.	.	.	.	.			.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410		.	.	.	.	.	.	.	.	.	420	.											.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.
Predicted Secondary structure								.	.																																	.												.	.	.	.	.	.	.	.	.	.
Query SS confidence								.	.																																	.												.	.	.	.	.	.	.	.	.	.
Query Sequence		L	F	E	F	A	S	.	.	E	L	K	A	D	N	V	L	Q	D	R	L	R	S	L	S	N	V	D	I	K	T	N	A	K	T	T	E	V	V	G	E	.	D	H	V	T	G	I	R	Y	E	D	M	.	.	.	.	.	.	.	.	.	.	N	T	G	E	E	H	L	L	N	L	D	G	I	F	V	Q	I	G
Query Conservation								.	.																																	.												.	.	.	.	.	.	.	.	.	.
Alig confidence								.	.																.																	.												.	.	.	.	.	.	.	.	.	.
Template Conservation																									.
Template Sequence		L	V	F	R	K	G	F	V	N	I	R	A	V	P	E	E	V	E	L	A	K	E	E	.	K	C	E	F	L	P	F	L	S	P	R	K	V	I	V	K	G	G	R	I	V	A	V	Q	F	V	R	T	E	Q	D	E	T	G	K	W	N	E	D	E	D	Q	I	V	H	L	K	A	D	V	V	I	S	A	F	G
Template Known Secondary structure					S	S		G	G	G			S											T	.	T						S										S	S	S													S	S	S															S
Template Predicted Secondary structure																									.
Template SS confidence
		361	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.		.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.
		440	.	.	.	.	.	.	.	.	.				450	.	.	.	.	.	.	.	.	.	460	.	.		.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.
Predicted Secondary structure												.	.	.														.
Query SS confidence												.	.	.														.
Query Sequence		L	L	P	N	T	S	W	L	N	D	.	.	.	A	V	E	L	N	E	R	G	E	I	V	I	D	.	R	N	N	N	T	N	V	P	G	I	F	A	A	G	D	V	T	D	Q	K	N	K	Q	I	I	I	S	M	G	A	G	A	N	A	A	L	N	A	F	D	Y	I
Query Conservation												.	.	.														.
Alig confidence												.	.	.														.																					.
Template Conservation																																																	.
Template Sequence		S	V	L	R	D	P	K	V	K	E	A	L	S	P	I	K	F	N	R	W	D	L	P	E	V	D	P	E	T	M	Q	T	S	E	P	W	V	F	A	G	G	D	I	V	G	M	A	.	N	T	T	V	E	S	V	N	D	G	K	Q	A	S	W	Y	I	H	K	Y	I
Template Known Secondary structure												T	T	T	T	S		B		T	T	S	S	B				T	T	T		B		S	S	T	T					G	G	G	G	T			.		S
Template Predicted Secondary structure																																																	.
Template SS confidence
		440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.		.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.