|   |   |
184 | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | |
|
. | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . |
| Predicted Secondary structure |   |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . |  |
|
|  |  |  |  |  |  |  |  |
|
|  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
Q | P | K | S | Q | E | N | D | I | R | S | C | C | L | A | E | I | R | Q | T | E | E | K | Y | T | E | T | L | E | S | I | E | K | Y | F | M | A | P | L | K | R | . |
. |
F | L | T | A | A | E | F | D | S | V | F | I | N | I | P | D | L |
| Query Conservation |   |
  |   |   |   |   |   |   |   |
|
|   |   |
|
|   |
|
|
|   |
|
|   |   |
|
|   |   |
|   |   |
|   |   |   |   |   |   |   |
|   |   | . | . |   |
|   |   |   |   |   |   |   |
|
|   |
|
|   |   |
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |
|
|   |   |
|   |
|
|   |   |   |
|   |
|
|
|   |
|
|   |   |
|
|   |   |
|   |   |
|   |   |   |
|   |   |   |
|   |   |   |   |   |
|   |   |   |   |   |   |   |
|
|   |   |
|   |   |
|
| Template Sequence |   |
D | M | L | T | P | T | E | R | K | R | Q | G | Y | I | H | E | L | I | V | T | E | E | N | Y | V | N | D | L | Q | L | V | T | E | I | F | Q | K | P | L | M | E | S | E | L | L | T | E | K | E | V | A | M | I | F | V | N | W | K | E | L |
| Template Known Secondary structure |   |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |  |  |  |  |  |  |  | T | S | S |
|  |  |  |  |  |  |  |  | T | T |  |  |  |  |
| Template Predicted Secondary structure |   |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1229 | 1230 | . | . | . | . | . | . | . | . | . | 1240 | . | . | . | . | . | . | . | . | . | 1250 | . | . | . | . | . | . | . | . | . | 1260 | . | . | . | . | . | . | . | . | . | 1270 | . | . | . | . | . | . | . | . | . | 1280 | . | . | . | . | . | . | . | . |
|   |
|   |   |
242 | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | |
|
|
|
. | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
| . | . | . | . |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
V | K | V | H | R | S | L | M | Q | E | I | H | D | S | I | V | N | K | D | . |
. |
. |
. |
D | Q | N | L | Y | Q | V | F | I | N | Y | K | E | R | L | V | I | Y | G | Q | Y | C | S | G | V | E | S | A | I | S | N | L | D | Y | I | S | K |
| Query Conservation |   |
  |   |   |   |   |   |
|
|   |   |
|   |   |   |   |   |   |   |   | . | . | . | . |   |   |   |
|
|   |   |
|   |   |   |   |   |   |
|   |   |
|   |   |
|   |   |
|   |   |   |
|   |   |   |
|   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |
|   |   |
|
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |
| Template Sequence |   |
I | M | C | N | I | K | L | L | K | A | L | R | V | R | K | K | M | S | G | E | K | M | P | V | K | M | I | G | D | I | L | S | A | Q | L | P | H | M | Q | P | Y | I | R | F | C | S | R | Q | L | N | G | A | A | L | I | Q | Q | K | T | D |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| T | T | S |
|
|
|
|
|  |  |  |  |  |  |  | G | G | G | G | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1289 | 1290 | . | . | . | . | . | . | . | . | . | 1300 | . | . | . | . | . | . | . | . | . | 1310 | . | . | . | . | . | . | . | . | . | 1320 | . | . | . | . | . | . | . | . | . | 1330 | . | . | . | . | . | . | . | . | . | 1340 | . | . | . | . | . | . | . | . |
|   |
|   |   |
298 | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | |
. | . | . | 350 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| . |
|
|  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
T | K | E | D | V | K | L | K | L | E | E | C | S | K | R | A | N | N | G | K | F | T | L | R | D | L | L | V | V | P | M | Q | R | V | L | K | Y | H | L | L | L | Q | E | L | V | K | H | T | H | . |
D | P | M | E | K | A | N | L | K | L |
| Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|
|   |
|
|
|
|
|   |
|
|   |
|
|
|   |   |
|   |
|   |
|   | . |   |   |   |
|   |   |   |
|   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |
|
|
|
|
|   |
|
|   |
|
|
|   |   |
|   |
|   |
|   |   |   |   |   |
|   |   |   |
|   |   |
| Template Sequence |   |
E | A | P | D | F | K | E | F | V | K | R | L | E | M | D | P | R | C | K | G | M | P | L | S | S | F | I | L | K | P | M | Q | R | V | T | R | Y | P | L | I | I | K | N | I | L | E | N | T | P | E | N | H | P | D | H | S | H | L | K | H |
| Template Known Secondary structure |   |
 |
|  |  |  |  |  |  |  |  |  |  |  | T | S | G | G | G | T | T |
|
|  |  |  |  | T | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | S |
| T | T | S | T | T |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1349 | 1350 | . | . | . | . | . | . | . | . | . | 1360 | . | . | . | . | . | . | . | . | . | 1370 | . | . | . | . | . | . | . | . | . | 1380 | . | . | . | . | . | . | . | . | . | 1390 | . | . | . | . | . | . | . | . | . | 1400 | . | . | . | . | . | . | . | . |
|   |
|   |   |
357 | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | |
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | . | 400 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|  |  |  |  |  |
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
A | L | D | A | M | K | D | L | A | Q | Y | V | N | E | V | K | R | D | N | E | T | L | R | E | I | K | Q | F | Q | L | S | I | E | N | L | N | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
Q | P | V | L | L | F | G | R | P | Q | G | D | G | E |
| Query Conservation |   |
|   |   |   |   |   |   |
|   |   |   |
|
|
|   |   |
|   |   |
|   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |   | . | . | . | . | . | . | . | . | . | . |   |   |
|   |   |   |   |   |
|   |   |   |
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
A | L | E | K | A | E | E | L | C | S | Q | V | N | E | G | V | R | E | K | E | N | S | D | R | L | E | W | I | Q | A | H | V | Q | C | E | G | L | S | E | Q | L | V | F | N | S | V | T | N | C | L | G | P | R | K | F | L | H | S | G | K |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T |  |  |
|
|
|
| S | S |
|
|
| S | S | S | B |
| S | S | S | S | B |
|
|  |  |  |  |
|
|
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |
|
|
|
|
|  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1409 | 1410 | . | . | . | . | . | . | . | . | . | 1420 | . | . | . | . | . | . | . | . | . | 1430 | . | . | . | . | . | . | . | . | . | 1440 | . | . | . | . | . | . | . | . | . | 1450 | . | . | . | . | . | . | . | . | . | 1460 | . | . | . | . | . | . | . | . |
|   |
|   |   |
407 | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
. | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |
|
|
| . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
I | R | I | T | T | L | D | K | H | T | K | Q | E | R | H | I | F | L | F | D | L | A | V | I | V | C | K | R | K | G | D | . |
. |
. |
. |
. |
. |
. |
. |
. |
N | Y | E | M | K | E | I | I | D | L | Q | Q | Y | K | I | A | N | N | P | T |
| Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|
|   |   |   |
|
|   |   |
|   |   |   |   | . | . | . | . | . | . | . | . | . |   |   |   |   |
|   |   |   |   |
|   |   |   |   |
|   |   |   |   |   |
| Alig confidence |   |
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |   |   |   |
|   |   |   |   |   |
| Template Sequence |   |
L | . |
. |
. |
. |
Y | K | A | K | N | N | K | E | L | Y | G | F | L | F | N | D | F | L | L | L | T | Q | I | T | K | P | K | V | F | S | P | K | S | N | L | Q | Y | M | Y | K | T | P | I | F | L | N | E | V | L | V | K | L | P | T | D |
| Template Known Secondary structure |   |
| . | . | . | . | B |
| S | S | S |
|
|
|
|  |  |  |  |  | S | S |  |  |  |  |  |  |  |  |
|
|
|
| S |
| S | S |
|
|  |  |  |  |
| S | S |
|  |  | G | G | G |  |  |  |  |
|
| S | S |
| Template Predicted Secondary structure |   |
 | . | . | . | . |  |  |
|
|
|
|
|  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1469 | |
|
|
|
1470 | . | . | . | . | . | . | . | . | . | 1480 | . | . | . | . | . | . | . | . | . | 1490 | . | . | . | . | . | . | . | . | . | 1500 | . | . | . | . | . | . | . | . | . | 1510 | . | . | . | . | . | . | . | . | . | 1520 | . | . | . | . |
|   |
|   |   |
458 | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . |
| Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
T | D | K | E | N | K | K | W | S | Y | G | F | Y | L | I | H | T | Q | G | Q | N | G | L | E | F | Y | C | K | T | K | D | L | K | K | K | W | L | E | Q | F | E | M | A | L | S | N | I | R | P | D | Y | A | D | S | N |
| Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |
|   |   |
|   |   |   |
|   |   |
|   |   |   |   |   |
|   |   |   |   |   |   |
| Alig confidence |   |
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  | . | . | . | . | . | . | . |   |   |   |
|   |
|   |   |   |   | . | . |   |   |   |   |
|   |   |   |   |   |   |
|   |   |   |
|   |   |   |
|   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
P | . |
. |
. |
. |
. |
. |
. |
S | G | D | F | H | I | S | H | I | D | . |
. |
R | V | Y | T | L | R | A | E | S | I | N | E | R | T | A | W | V | Q | K | I | K | A | A | S | E | L | Y | I | E | T | E | K | K | K | R |
| Template Known Secondary structure |   |
S | . | . | . | . | . | . | . |
|
|
|
|  |  |  |  | T | T | . | . |  |  |  |  |
| B |
| S | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T |
|
|
| Template Predicted Secondary structure |   |
| . | . | . | . | . | . | . |
|
|  |  |  |  |  |  |
|
| . | . |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
1532 | |
|
|
|
|
|
|
. | . | . | . | . | . | . | 1540 | . | . | |
|
. | . | . | . | . | . | . | 1550 | . | . | . | . | . | . | . | . | . | 1560 | . | . | . | . | . | . | . | . | . | 1570 | . | . | . | . | . | . | . |
|   |