|   |   |
190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | |
|
|
. | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . |  |
|
|  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
N | D | I | R | S | C | C | L | A | E | I | R | Q | T | E | E | K | Y | T | E | T | L | E | S | I | E | K | Y | F | M | A | P | L | K | R | . |
. |
. |
F | L | T | A | A | E | F | D | S | V | F | I | N | I | P | D | L | V | K | V | H | R |
| Query Conservation |   |
  |   |
|
|   |   |
|
|   |
|
|
|   |
|
|   |   |
|
|   |   |
|   |   |
|   |   |   |   |   |   |   |
|   |   | . | . | . |   |
|   |   |   |   |   |   |   |
|
|   |
|
|   |   |
|   |   |   |   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|   |   |   |   |   |
|
|   |
|
|
|   |
|
|   |   |
|
|   |   |
|   |   |
|   |   |   |
|   |   |
|
|   |   |   |   |   |   |
|   |   |   |   |   |   |   |
|
|   |   |
|
|   |
|   |   |   |
|   |
| Template Sequence |   |
E | Q | T | Y | Y | D | L | V | K | A | F | X | A | E | I | R | Q | Y | I | R | E | L | N | L | I | I | K | V | F | R | E | P | F | V | S | N | S | K | L | F | S | A | N | D | V | E | N | I | F | S | R | I | V | D | I | H | E | L | S | V |
| Template Known Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | T |  |  |  |  |  |
| T | T | T |
|
|  |  |  |  |  |  |  |  | T | T |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
198 | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . |
|   |
|   |   |
247 | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | |
|
|
|
. | . | . | . | . | . | 270 | . | . | . | |
|
. | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | |
|
. |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  | . | . | . | . |  |  |  |  |  |  |  |  |  |  | . | . |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  | . | . |
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
| Query Sequence |   |
S | L | M | Q | E | I | H | D | S | I | V | N | K | D | D | Q | N | . |
. |
. |
. |
L | Y | Q | V | F | I | N | Y | K | E | . |
. |
R | L | V | I | Y | G | Q | Y | C | S | G | V | E | S | A | I | S | N | L | D | Y | I | S | K | . |
. |
T |
| Query Conservation |   |
  |
|
|   |   |
|   |   |   |   |   |   |   |   |   |   |   | . | . | . | . |
|
|   |   |
|   |   |   |   |   | . | . |   |
|   |   |
|   |   |
|   |   |
|   |   |   |
|   |   |   |
|   |   |   |   |   | . | . |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
| Template Conservation |   |
  |
|
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
| Template Sequence |   |
K | L | L | G | H | I | E | D | T | V | E | X | T | D | E | G | S | P | H | P | L | V | G | S | C | F | E | D | L | A | E | E | L | A | F | D | P | Y | E | S | Y | A | R | D | I | L | R | P | G | F | H | D | R | F | L | S | Q | L | S | K |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  | T |
|
| T | T | S | S | S |
|
|
|  |  |  |  |  |  |  |  |  | T | T | T | T |  |  |  |  |  |  |  |  |  |  | T | S | T | T |  |  |  |  |  |  |  |  |  |  | S |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
258 | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . |
|   |
|   |   |
299 | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
K | E | D | V | K | L | K | L | E | E | C | S | K | R | A | N | N | G | K | F | T | L | R | D | L | L | V | V | P | M | Q | R | V | L | K | Y | H | L | L | L | Q | E | L | V | K | H | T | H | D | P | M | E | K | A | N | L | K | L | A | L |
| Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|
|   |
|
|
|
|
|   |
|
|   |
|
|
|   |   |
|   |
|   |
|   |   |   |   |
|   |   |   |
|   |   |
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|   |   |   |
|   |   |
|
|
|
|
|   |
|
|   |
|
|
|   |   |
|   |
|   |
|   |   |   |   |
|   |   |   |
|   |   |
|   |
| Template Sequence |   |
P | G | A | A | L | Y | L | Q | S | I | G | E | G | F | K | E | A | V | Q | Y | V | L | P | R | L | L | L | A | P | V | Y | H | C | L | H | Y | F | E | L | L | K | Q | L | E | E | K | S | E | D | Q | E | D | K | E | C | L | K | Q | A | I |
| Template Known Secondary structure |   |
T | T |  |  |  |  |  |  |  |  |
| T | T |  |  |  |  |  |  |  | T |  |  |  |  | T | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| S |
|  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
318 | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . |
|   |
|   |   |
359 | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | |
|
|
|
|
|
|
|
|
. | . | . | . | . | . | 390 | . | . | . | |
. | . | . | . | . | . | 400 | |
. | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . | . | . | . | . | . | . |  |  |  |  |  |
|
|
|
|
| . |
|
|
|
|
|
|  | . |  |  |  |  |
|
|  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
| Query Sequence |   |
D | A | M | K | D | L | A | Q | Y | V | N | E | V | K | R | D | N | E | T | L | R | E | I | K | Q | . |
. |
. |
. |
. |
. |
. |
. |
. |
F | Q | L | S | I | E | N | L | N | Q | . |
P | V | L | L | F | G | R | . |
P | Q | G | D | G | E | I |
| Query Conservation |   |
  |   |   |   |   |
|   |   |   |
|
|
|   |   |
|   |   |
|   |   |   |   |   |   |   | . | . | . | . | . | . | . | . | . |
|   |   |   |
|   |   |   |   |   | . |   |
|   |   |   |   |   | . |
|   |   |   |
|   |   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |
|   |   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |
|   |
|   |   |   |
|   |   |
| Template Sequence |   |
T | A | L | L | N | V | Q | S | G | X | E | K | I | C | S | K | S | L | A | K | R | R | L | S | E | S | A | A | I | K | K | X | N | E | I | Q | K | N | I | D | G | W | E | G | K | D | I | G | Q | C | C | N | E | F | I | X | E | G | T | L |
| Template Known Secondary structure |   |
 |  | T |  |  |  |  |  |  |  |  |  |  |  |  | S |  |  |  |  |  |  |  |  |  | T |
|
| T |  |  |  |  |  |  |  | T | T |  |  | S |
|
| S | S |
| G | G | G | T |
|
|
|  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
378 | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . |
|   |
|   |   |
408 | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
. | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |
|
|
|  | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
R | I | T | T | L | D | K | H | T | K | Q | E | R | H | I | F | L | F | D | L | A | V | I | V | C | K | R | K | G | D | N | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
Y | E | M | K | E | I | I | D | L | Q | Q | Y | K | I | A | N | N | P | T |
| Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|
|   |   |   |
|
|   |   |
|   |   |   |   |   | . | . | . | . | . | . | . | . | . | . |   |   |   |
|   |   |   |   |
|   |   |   |   |
|   |   |   |   |   |
| Alig confidence |   |
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
| Template Conservation |   |
  | . | . | . | . |   |   |   |   |   |   |   |   |   |   |
|
|
|   |
|   |
|
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   | . |
| Template Sequence |   |
T | . |
. |
. |
. |
R | V | G | A | K | H | E | R | H | I | F | L | F | D | G | L | X | I | C | C | K | S | N | H | G | Q | P | R | L | P | G | A | S | N | A | E | Y | R | L | K | E | K | F | F | X | R | K | V | Q | I | N | D | K | D | . |
| Template Known Secondary structure |   |
 | . | . | . | . |  | T | T |
| S | S |
|  |  |  |  |  |  | S | S |  |  |  |  |  |  |  |
| T | T |
|
|
|
| T | T | S |
|
|
| S |  |  |  |  |  |  |  |  | S |
| S |
|  |  |  |  |
|
| . |
| Template Predicted Secondary structure |   |
 | . | . | . | . |  |
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |
|
| . |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
451 | |
|
|
|
. | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | |
|   |
|   |   |
458 | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . |
| Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
T | D | K | E | N | K | K | W | S | Y | G | F | Y | L | I | H | T | Q | G | Q | N | G | L | E | F | Y | C | K | T | K | D | L | K | K | K | W | L | E | Q | F | E | M | A | L |
| Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |
|   |   |
|   |   |   |
|   |   |
|   |
| Alig confidence |   |
. | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
. | . | . |   |   |   |   |   |   |   |   |
|   |
|   |   |   |   |   |   | . |   |   |   |
|   |   |   |
|   |   |
|
|   |   |
|   |   |   |
|   |   |   |   |
| Template Sequence |   |
. |
. |
. |
D | T | N | E | Y | K | H | A | F | E | I | I | L | K | D | E | N | . |
S | V | I | F | S | A | K | S | A | E | E | K | N | N | W | X | A | A | L | I | S | L | Q |
| Template Known Secondary structure |   |
. | . | . |
| S | S | S |
|
| S |  |  |  |  |
|
| T | T | S |
| . |
|  |  |  |  |
| S | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
. | . | . |
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
| . |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
|
|
|
506 | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | |
. | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540 | . | . | . | . | . |
|   |