Email l.a.kelley@imperial.ac.uk Description Q62415 Date Tue Jul 30 13:16:45 BST 2013 Unique Job ID eb04dc0bf7b652f9

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1ycsB_ 100.0 81 PDB header:complex (anti-oncogene/ankyrin repeats) Chain: B: PDB Molecule:53bp2; PDBTitle: p53-53bp2 complex 2 c2vgeA_ 99.9 56 PDB header:transcription Chain: A: PDB Molecule:rela-associated inhibitor; PDBTitle: crystal structure of the c-terminal region of human iaspp 3 c2uwqA_ 99.8 69 PDB header:apoptosis Chain: A: PDB Molecule:apoptosis-stimulating of p53 protein 2; PDBTitle: solution structure of aspp2 n-terminus 4 c1mv3A_ 99.7 30 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:myc box dependent interacting protein 1; PDBTitle: nmr structure of the tumor suppressor bin1: alternative2 splicing in melanoma and interaction with c-myc 5 d1ycsb2 99.7 71 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 6 c1griA_ 99.7 17 PDB header:signal transduction adaptor Chain: A: PDB Molecule:growth factor bound protein 2; PDBTitle: grb2 7 c2lqnA_ 99.7 12 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 8 c1ng2A_ 99.7 20 PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosolic factor 1; PDBTitle: structure of autoinhibited p47phox 9 c2eyzA_ 99.6 14 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 10 c3jv3A_ 99.6 35 PDB header:protein binding Chain: A: PDB Molecule:intersectin-1; PDBTitle: structure of sh3e-dh unit of murine intersectin-1l 11 c2l3sA_ 99.6 13 PDB header:structural protein Chain: A: PDB Molecule:autoinhibited crk protein; PDBTitle: structure of the autoinhibited crk 12 c1ov3A_ 99.6 23 PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosol factor 1; PDBTitle: structure of the p22phox-p47phox complex 13 d1udla_ 99.6 24 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 14 c3nmzD_ 99.6 28 PDB header:cell adhesion/cell cycle Chain: D: PDB Molecule:rho guanine nucleotide exchange factor 4; PDBTitle: crytal structure of apc complexed with asef 15 c2dx1A_ 99.6 38 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 4; PDBTitle: crystal structure of rhogef protein asef 16 d1ng2a2 99.6 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 17 c2rqrA_ 99.6 15 PDB header:protein binding Chain: A: PDB Molecule:engulfment and cell motility protein 1, linker, dedicator PDBTitle: the solution structure of human dock2 sh3 domain - elmo1 peptide2 chimera complex 18 c2kymA_ 99.6 25 PDB header:signaling protein Chain: A: PDB Molecule:bud emergence protein 1; PDBTitle: solution structure of the bem1p sh3-ci domain from l.elongisporus in2 complex with ste20p peptide 19 c1wyxA_ 99.6 35 PDB header:cell adhesion Chain: A: PDB Molecule:crk-associated substrate; PDBTitle: the crystal structure of the p130cas sh3 domain at 1.1 a2 resolution 20 d1i1ja_ 99.6 24 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 21 c1x2qA_ not modelled 99.6 27 PDB header:signaling protein Chain: A: PDB Molecule:signal transducing adapter molecule 2; PDBTitle: solution structure of the sh3 domain of the signal2 transducing adaptor molecule 2 22 d1ug1a_ not modelled 99.5 22 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 23 c2ekhA_ not modelled 99.5 25 PDB header:signaling protein Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a; PDBTitle: solution structures of the sh3 domain of human kiaa0418 24 c2jxbA_ not modelled 99.5 28 PDB header:signaling protein complex Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 epsilon chain, PDBTitle: structure of cd3epsilon-nck2 first sh3 domain complex 25 c2dlpA_ not modelled 99.5 32 PDB header:structural protein Chain: A: PDB Molecule:kiaa1783 protein; PDBTitle: solution structure of the sh3 domain of human kiaa17832 protein 26 c2yunA_ not modelled 99.5 28 PDB header:protein transport Chain: A: PDB Molecule:nostrin; PDBTitle: solution structure of the sh3 domain of human nostrin 27 c2csqA_ not modelled 99.5 29 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:rim binding protein 2; PDBTitle: solution structure of the second sh3 domain of human rim-2 binding protein 2 28 c2ysqA_ not modelled 99.5 31 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 9; PDBTitle: solution structure of the sh3 domain from rho guanine2 nucleotide exchange factor 9 29 c2dl7A_ not modelled 99.5 32 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:kiaa0769 protein; PDBTitle: solution structure of the second sh3 domain of human2 kiaa0769 protein 30 c2dnuA_ not modelled 99.5 26 PDB header:structural genomics, structural protein Chain: A: PDB Molecule:sh3 multiple domains 1; PDBTitle: solution structure of rsgi ruh-061, a sh3 domain from human 31 c2cubA_ not modelled 99.5 21 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck1 32 c2i0nA_ not modelled 99.5 24 PDB header:structural protein Chain: A: PDB Molecule:class vii unconventional myosin; PDBTitle: structure of dictyostelium discoideum myosin vii sh3 domain2 with adjacent proline rich region 33 c2yupA_ not modelled 99.5 26 PDB header:cell adhesion Chain: A: PDB Molecule:vinexin; PDBTitle: solution structure of the second sh3 domain of human vinexin 34 c2e5kA_ not modelled 99.5 24 PDB header:protein binding Chain: A: PDB Molecule:suppressor of t-cell receptor signaling 1; PDBTitle: solution structure of sh3 domain in suppressor of t-cell2 receptor signaling 1 35 c4glmD_ not modelled 99.5 32 PDB header:signaling protein Chain: D: PDB Molecule:dynamin-binding protein; PDBTitle: crystal structure of the sh3 domain of dnmbp protein [homo sapiens] 36 c1x6gA_ not modelled 99.5 20 PDB header:signaling protein Chain: A: PDB Molecule:megakaryocyte-associated tyrosine-protein kinase; PDBTitle: solution structures of the sh3 domain of human2 megakaryocyte-associated tyrosine-protein kinase. 37 c2yuoA_ not modelled 99.5 28 PDB header:signaling protein Chain: A: PDB Molecule:run and tbc1 domain containing 3; PDBTitle: solution structure of the sh3 domain of mouse run and tbc12 domain containing 3 38 c2dbmA_ not modelled 99.5 31 PDB header:transferase, signaling protein Chain: A: PDB Molecule:sh3-containing grb2-like protein 2; PDBTitle: solution structures of the sh3 domain of human sh3-2 containing grb2-like protein 2 39 c2eyyA_ not modelled 99.5 24 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 40 c2djqA_ not modelled 99.5 25 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:sh3 domain containing ring finger 2; PDBTitle: the solution structure of the first sh3 domain of mouse sh32 domain containing ring finger 2 41 c2xmfA_ not modelled 99.5 36 PDB header:motor protein Chain: A: PDB Molecule:myosin 1e sh3; PDBTitle: myosin 1e sh3 42 d1gbra_ not modelled 99.5 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 43 d1ov3a2 not modelled 99.5 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 44 c2dl8A_ not modelled 99.5 25 PDB header:signaling protein Chain: A: PDB Molecule:slit-robo rho gtpase-activating protein 2; PDBTitle: solution structure of the sh3 domain of human slit-robo rho2 gtpase-activating protein 2 45 c2oi3A_ not modelled 99.5 36 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: nmr structure analysis of the hematopoetic cell kinase sh32 domain complexed with an artificial high affinity ligand3 (pd1) 46 c2yt6A_ not modelled 99.5 25 PDB header:cell cycle Chain: A: PDB Molecule:adult male urinary bladder cdna, riken full- PDBTitle: solution structure of the sh3_1 domain of yamaguchi sarcoma2 viral (v-yes) oncogene homolog 1 47 c1w70A_ not modelled 99.5 24 PDB header:sh3 domain Chain: A: PDB Molecule:neutrophil cytosol factor 4; PDBTitle: sh3 domain of p40phox complexed with c-terminal polyproline2 region of p47phox 48 c2nwmA_ not modelled 99.5 29 PDB header:cell adhesion Chain: A: PDB Molecule:vinexin; PDBTitle: solution structure of the first sh3 domain of human vinexin2 and its interaction with the peptides from vinculin 49 c2creA_ not modelled 99.5 34 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hef-like protein; PDBTitle: solution structure of rsgi ruh-036, an sh3 domain from2 human cdna 50 d1uj0a_ not modelled 99.5 36 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 51 c1wx6A_ not modelled 99.5 22 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:cytoplasmic protein nck2; PDBTitle: solution structure of the sh3 domain of the human2 cytoplasmic protein nck2 52 c1x43A_ not modelled 99.5 31 PDB header:endocytosis/exocytosis Chain: A: PDB Molecule:sh3 domain grb2-like protein b1; PDBTitle: solution structure of the sh3 domain of endophilin b12 (sh3g1b1) 53 c2a28D_ not modelled 99.5 34 PDB header:signaling protein Chain: D: PDB Molecule:bzz1 protein; PDBTitle: atomic-resolution crystal structure of the second sh32 domain of yeast bzz1 determined from a pseudomerohedrally3 twinned crystal 54 c2d8hA_ not modelled 99.5 31 PDB header:unknown function Chain: A: PDB Molecule:sh3yl1 protein; PDBTitle: solution structure of the sh3 domain of hypothetical2 protein sh3yl1 55 c2ebpA_ not modelled 99.5 18 PDB header:cell adhesion Chain: A: PDB Molecule:sam and sh3 domain-containing protein 1; PDBTitle: solution structure of the sh3 domain from human sam and sh32 domain containing protein 1 56 c1x2pA_ not modelled 99.5 32 PDB header:transferase Chain: A: PDB Molecule:protein arginine n-methyltransferase 2; PDBTitle: solution structure of the sh3 domain of the protein2 arginine n-methyltransferase 2 57 c2azsA_ not modelled 99.5 32 PDB header:signaling protein Chain: A: PDB Molecule:sh2-sh3 adapter protein drk; PDBTitle: nmr structure of the n-terminal sh3 domain of drk2 (calculated without noe restraints) 58 c2ed0A_ not modelled 99.5 25 PDB header:signaling protein Chain: A: PDB Molecule:abl interactor 2; PDBTitle: solution structure of the sh3 domain of abl interactor 22 (abelson interactor 2) 59 d1jqqa_ not modelled 99.5 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 60 d1uffa_ not modelled 99.5 29 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 61 d1j3ta_ not modelled 99.5 25 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 62 c2l0aA_ not modelled 99.5 35 PDB header:signaling protein Chain: A: PDB Molecule:signal transducing adapter molecule 1; PDBTitle: solution nmr structure of signal transducing adapter molecule 1 stam-12 from homo sapiens, northeast structural genomics consortium target3 hr4479e 63 c2dilA_ not modelled 99.5 28 PDB header:cell adhesion Chain: A: PDB Molecule:proline-serine-threonine phosphatase-interacting PDBTitle: solution structure of the sh3 domain of the human proline-2 serine-threonine phosphatase-interacting protein 1 64 c2ct4A_ not modelled 99.5 25 PDB header:signaling protein Chain: A: PDB Molecule:cdc42-interacting protein 4; PDBTitle: solution strutcure of the sh3 domain of the cdc42-2 interacting protein 4 65 c2df6A_ not modelled 99.5 33 PDB header:signaling protein Chain: A: PDB Molecule:rho guanine nucleotide exchange factor 7; PDBTitle: crystal structure of the sh3 domain of betapix in complex2 with a high affinity peptide from pak2 66 c3qwxX_ not modelled 99.5 19 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 67 c2d1xD_ not modelled 99.5 38 PDB header:cell invasion Chain: D: PDB Molecule:cortactin isoform a; PDBTitle: the crystal structure of the cortactin-sh3 domain and amap1-2 peptide complex 68 c2rqvA_ not modelled 99.5 27 PDB header:signaling protein Chain: A: PDB Molecule:bud emergence protein 1; PDBTitle: solution structure of sh3ci domain of bem1p 69 c4igzA_ not modelled 99.5 33 PDB header:protein binding Chain: A: PDB Molecule:sorbin and sh3 domain-containing protein 2; PDBTitle: crystal structure of the sh3 domain of human sorbin and sh3 domain-2 containing protein 2 70 c2dl3A_ not modelled 99.5 28 PDB header:cell adhesion, signaling protein Chain: A: PDB Molecule:sorbin and sh3 domain-containing protein 1; PDBTitle: solution structure of the first sh3 domain of human sorbin2 and sh3 domain-containing protein 1 71 c1zlmA_ not modelled 99.5 39 PDB header:signaling protein Chain: A: PDB Molecule:osteoclast stimulating factor 1; PDBTitle: crystal structure of the sh3 domain of human osteoclast2 stimulating factor 72 c2egeA_ not modelled 99.5 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein kiaa1666; PDBTitle: solution structure of the third sh3 domain from human2 kiaa1666 protein 73 c2ed1A_ not modelled 99.5 32 PDB header:signaling protein Chain: A: PDB Molecule:130 kda phosphatidylinositol 4,5-biphosphate- PDBTitle: solution structure of the sh3 domain of 130 kda2 phosphatidylinositol 4,5-biphosphate-dependent arf1 gtpase-3 activating protein 74 c3rnjA_ not modelled 99.5 31 PDB header:protein binding Chain: A: PDB Molecule:brain-specific angiogenesis inhibitor 1-associated protein PDBTitle: crystal structure of the sh3 domain from irsp53 (baiap2) 75 c2epdA_ not modelled 99.5 25 PDB header:protein binding Chain: A: PDB Molecule:rho gtpase-activating protein 4; PDBTitle: solution structure of sh3 domain in rho-gtpase-activating2 protein 4 76 d1wiea_ not modelled 99.5 27 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 77 d1oeba_ not modelled 99.5 31 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 78 c2dl4A_ not modelled 99.5 29 PDB header:signaling protein Chain: A: PDB Molecule:protein stac; PDBTitle: solution structure of the first sh3 domain of stac protein 79 d1k4us_ not modelled 99.5 35 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 80 d1k9aa1 not modelled 99.5 23 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 81 c2enmA_ not modelled 99.5 21 PDB header:endocytosis Chain: A: PDB Molecule:sorting nexin-9; PDBTitle: solution structure of the sh3 domain from mouse sorting2 nexin-9 82 c2dmoA_ not modelled 99.5 19 PDB header:signaling protein Chain: A: PDB Molecule:neutrophil cytosol factor 2; PDBTitle: refined solution structure of the 1st sh3 domain from human2 neutrophil cytosol factor 2 (ncf-2) 83 d1utia_ not modelled 99.5 33 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 84 c2k2mA_ not modelled 99.5 37 PDB header:signaling protein Chain: A: PDB Molecule:eps8-like protein 1; PDBTitle: structural basis of pxxdy motif recognition in sh3 binding 85 c3qwyA_ not modelled 99.5 25 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 86 d1uuea_ not modelled 99.5 30 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 87 c1zukA_ not modelled 99.5 30 PDB header:contractile protein Chain: A: PDB Molecule:myosin tail region-interacting protein mti1; PDBTitle: yeast bbc1 sh3 domain complexed with a peptide from las17 88 c1x69A_ not modelled 99.5 31 PDB header:signaling protein Chain: A: PDB Molecule:cortactin isoform a; PDBTitle: solution structures of the sh3 domain of human src2 substrate cortactin 89 c1z9qA_ not modelled 99.5 24 PDB header:oxidoreductase activator Chain: A: PDB Molecule:neutrophil cytosol factor 4; PDBTitle: solution structure of sh3 domain of p40phox 90 c2dbkA_ not modelled 99.5 15 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structures of the sh3 domain of human crk-like2 protein 91 c2fpeB_ not modelled 99.5 17 PDB header:signaling protein Chain: B: PDB Molecule:c-jun-amino-terminal kinase interacting protein PDBTitle: conserved dimerization of the ib1 src-homology 3 domain 92 c4esrB_ not modelled 99.5 43 PDB header:protein binding Chain: B: PDB Molecule:jouberin; PDBTitle: molecular and structural characterization of the sh3 domain of ahi-12 in regulation of cellular resistance of bcr-abl+ chronic myeloid3 leukemia cells to tyrosine kinase inhibitors 93 d1n11a_ not modelled 99.5 33 Fold:beta-hairpin-alpha-hairpin repeat Superfamily:Ankyrin repeat Family:Ankyrin repeat 94 c1n11A_ not modelled 99.5 33 PDB header:structural protein Chain: A: PDB Molecule:ankyrin; PDBTitle: d34 region of human ankyrin-r and linker 95 d1ujya_ not modelled 99.5 32 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 96 d1spka_ not modelled 99.5 23 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 97 c1zx6A_ not modelled 99.5 29 PDB header:protein binding Chain: A: PDB Molecule:ypr154wp; PDBTitle: high-resolution crystal structure of yeast pin3 sh3 domain 98 d1gcqa_ not modelled 99.5 35 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 99 c1wi7A_ not modelled 99.5 29 PDB header:protein binding Chain: A: PDB Molecule:sh3-domain kinase binding protein 1; PDBTitle: solution structure of the sh3 domain of sh3-domain kinase2 binding protein 1 100 c2o2oA_ not modelled 99.5 30 PDB header:protein binding Chain: A: PDB Molecule:sh3-domain kinase-binding protein 1; PDBTitle: solution structure of domain b from human cin85 protein 101 c2cudA_ not modelled 99.5 22 PDB header:signaling protein Chain: A: PDB Molecule:src-like-adapter; PDBTitle: solution structure of the sh3 domain of the human src-like2 adopter protein (slap) 102 c2dl5A_ not modelled 99.5 30 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:kiaa0769 protein; PDBTitle: solution structure of the first sh3 domain of human2 kiaa0769 protein 103 c2eyxA_ not modelled 99.5 13 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: c-terminal sh3 domain of ct10-regulated kinase 104 d1oota_ not modelled 99.5 38 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 105 c2pqhA_ not modelled 99.5 29 PDB header:structural protein Chain: A: PDB Molecule:spectrin alpha chain, brain; PDBTitle: structure of sh3 chimera with a type ii ligand linked to the chain c-2 terminal 106 d1uhfa_ not modelled 99.4 31 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 107 c2kbtA_ not modelled 99.4 32 PDB header:signaling protein Chain: A: PDB Molecule:chimera of proto-oncogene vav, linker, PDBTitle: attachment of an nmr-invisible solubility enhancement tag2 (inset) using a sortase-mediated protein ligation method 108 c2drmB_ not modelled 99.4 42 PDB header:contractile protein Chain: B: PDB Molecule:acanthamoeba myosin ib; PDBTitle: acanthamoeba myosin i sh3 domain bound to acan125 109 c1wxuA_ not modelled 99.4 22 PDB header:protein transport Chain: A: PDB Molecule:peroxisomal biogenesis factor 13; PDBTitle: solution structure of the sh3 domain of mouse peroxisomal2 biogenesis factor 13 110 c2j06B_ not modelled 99.4 27 PDB header:signal transduction Chain: B: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: crystal structure of the rasgap sh3 domain at 1.8 angstrom2 resolution 111 c2rf0D_ not modelled 99.4 30 PDB header:transferase Chain: D: PDB Molecule:mitogen-activated protein kinase kinase kinase 10; PDBTitle: crystal structure of human mixed lineage kinase map3k10 sh3 domain 112 d1pwta_ not modelled 99.4 32 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 113 d1sema_ not modelled 99.4 43 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 114 d1e6ga_ not modelled 99.4 32 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 115 c2k6dA_ not modelled 99.4 37 PDB header:sh3 domain/ubiquitin Chain: A: PDB Molecule:sh3 domain-containing kinase-binding protein 1; PDBTitle: cin85 sh3-c domain in complex with ubiquitin 116 c2egaA_ not modelled 99.4 20 PDB header:signaling protein Chain: A: PDB Molecule:sh3 and px domain-containing protein 2a; PDBTitle: solution structure of the first sh3 domain from human2 kiaa0418 protein 117 d1nega_ not modelled 99.4 31 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 118 c1negA_ not modelled 99.4 31 PDB header:structural protein Chain: A: PDB Molecule:spectrin alpha chain, brain; PDBTitle: crystal structure analysis of n-and c-terminal labeled sh3-2 domain of alpha-chicken spectrin 119 c2krnA_ not modelled 99.4 34 PDB header:signaling protein Chain: A: PDB Molecule:cd2-associated protein; PDBTitle: high resolution structure of the second sh3 domain of cd2ap 120 d1gria2 not modelled 99.4 34 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain