Email l.a.kelley@imperial.ac.uk Description O08908 Date Wed Jul 10 14:15:46 BST 2013 Unique Job ID dde13fc30c6a1497

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2oq1A_ 100.0 28 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: tandem sh2 domains of zap-70 with 19-mer zeta1 peptide 2 c4fl2A_ 100.0 27 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase syk; PDBTitle: structural and biophysical characterization of the syk activation2 switch 3 c2ozoA_ 100.0 31 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase zap-70; PDBTitle: autoinhibited intact human zap-70 4 c2b3oA_ 100.0 35 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: crystal structure of human tyrosine phosphatase shp-1 5 c2shpA_ 100.0 26 PDB header:tyrosine phosphatase Chain: A: PDB Molecule:shp-2; PDBTitle: tyrosine phosphatase shp-2 6 c1a81E_ 100.0 31 PDB header:complex (transferase/peptide) Chain: E: PDB Molecule:syk kinase; PDBTitle: crystal structure of the tandem sh2 domain of the syk kinase bound to2 a dually tyrosine-phosphorylated itam 7 c3ps5A_ 100.0 28 PDB header:hydrolase, signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 6; PDBTitle: crystal structure of the full-length human protein tyrosine2 phosphatase shp-1 8 c3gqiB_ 100.0 34 PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:phospholipase c-gamma-1; PDBTitle: crystal structure of activated receptor tyrosine kinase in complex2 with substrates 9 c2y3aB_ 100.0 100 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of p110beta in complex with icsh2 of p85beta and2 the drug gdc-0941 10 c3hizB_ 100.0 77 PDB header:transferase/oncoprotein Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit PDBTitle: crystal structure of p110alpha h1047r mutant in complex with2 nish2 of p85alpha 11 c1xa6A_ 100.0 19 PDB header:signaling protein Chain: A: PDB Molecule:beta2-chimaerin; PDBTitle: crystal structure of the human beta2-chimaerin 12 c2xs6A_ 100.0 72 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit beta; PDBTitle: crystal structure of the rhogap domain of human pik3r2 13 c1pbwB_ 100.0 33 PDB header:phosphotransferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase; PDBTitle: structure of bcr-homology (bh) domain 14 c2ee5A_ 100.0 19 PDB header:hydrolase Chain: A: PDB Molecule:rho gtpase activating protein 5 variant; PDBTitle: solution structure of the n-teruminus extended rhogap2 domain from human rho gtpase activating protein 5 variant 15 c3qisA_ 100.0 22 PDB header:hydrolase/protein binding Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1; PDBTitle: recognition of the f&h motif by the lowe syndrome protein ocrl 16 d1pbwa_ 100.0 35 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:BCR-homology GTPase activation domain (BH-domain) 17 c2ovjA_ 100.0 27 PDB header:signaling protein Chain: A: PDB Molecule:rac gtpase-activating protein 1; PDBTitle: the crystal structure of the human rac gtpase activating protein 12 (racgap1) mgcracgap. 18 c2ngrB_ 100.0 23 PDB header:hydrolase Chain: B: PDB Molecule:protein (gtpase activating protein (rhg)); PDBTitle: transition state complex for gtp hydrolysis by cdc42:2 comparisons of the high resolution structures for cdc423 bound to the active and catalytically compromised forms of4 the cdc42-gap. 19 c3iugA_ 100.0 21 PDB header:splicing Chain: A: PDB Molecule:rho/cdc42/rac gtpase-activating protein rics; PDBTitle: crystal structure of the rhogap domain of rics 20 d1xa6a1 100.0 20 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:BCR-homology GTPase activation domain (BH-domain) 21 d1tx4a_ not modelled 100.0 23 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:BCR-homology GTPase activation domain (BH-domain) 22 c3byiA_ not modelled 100.0 20 PDB header:signaling protein Chain: A: PDB Molecule:rho gtpase activating protein 15; PDBTitle: crystal structure of human rho gtpase activating protein 15 (arhgap15) 23 c3kuqA_ not modelled 100.0 16 PDB header:hydrolase activator Chain: A: PDB Molecule:rho gtpase-activating protein 7; PDBTitle: crystal structure of the dlc1 rhogap domain 24 c3fk2B_ not modelled 100.0 19 PDB header:signaling protein, hydrolase activator Chain: B: PDB Molecule:glucocorticoid receptor dna-binding factor 1; PDBTitle: crystal structure of the rhogap domain of human2 glucocorticoid receptor dna-binding factor 1 25 c1f7cA_ not modelled 100.0 21 PDB header:signaling protein Chain: A: PDB Molecule:rhogap protein; PDBTitle: crystal structure of the bh domain from graf, the gtpase2 regulator associated with focal adhesion kinase 26 d1f7ca_ not modelled 100.0 21 Fold:GTPase activation domain, GAP Superfamily:GTPase activation domain, GAP Family:BCR-homology GTPase activation domain (BH-domain) 27 c3msxB_ not modelled 100.0 17 PDB header:protein binding Chain: B: PDB Molecule:rho gtpase-activating protein 20; PDBTitle: crystal structure of rhoa.gdp.mgf3 in complex with gap domain of2 arhgap20 28 c1k9aB_ 99.9 35 PDB header:transferase Chain: B: PDB Molecule:carboxyl-terminal src kinase; PDBTitle: crystal structure analysis of full-length carboxyl-terminal2 src kinase at 2.5 a resolution 29 c2fo0A_ not modelled 99.9 32 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase abl1 (1b isoform); PDBTitle: organization of the sh3-sh2 unit in active and inactive forms of the2 c-abl tyrosine kinase 30 c2qv2A_ not modelled 99.9 18 PDB header:hydrolase Chain: A: PDB Molecule:inositol polyphosphate 5-phosphatase ocrl-1; PDBTitle: a role of the lowe syndrome protein ocrl in early steps of2 the endocytic pathway 31 c1oplA_ not modelled 99.9 34 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase 32 c1y57A_ not modelled 99.9 53 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: structure of unphosphorylated c-src in complex with an inhibitor 33 d1pica_ not modelled 99.9 72 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 34 c1x27F_ not modelled 99.9 53 PDB header:signaling protein Chain: F: PDB Molecule:proto-oncogene tyrosine-protein kinase lck; PDBTitle: crystal structure of lck sh2-sh3 with sh2 binding site of2 p130cas 35 d1qada_ not modelled 99.9 78 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 36 d2oq1a1 not modelled 99.9 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 37 c2h8hA_ not modelled 99.9 53 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase src; PDBTitle: src kinase in complex with a quinazoline inhibitor 38 c2c0iA_ not modelled 99.9 40 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: src family kinase hck with bound inhibitor a-420983 39 c3eapD_ not modelled 99.9 17 PDB header:hydrolase activator Chain: D: PDB Molecule:rho gtpase-activating protein 11a; PDBTitle: crystal structure of the rhogap domain of arhgap11a 40 c2eo6A_ not modelled 99.9 30 PDB header:signaling protein Chain: A: PDB Molecule:b-cell linker protein; PDBTitle: solution structure of the sh2 domain from mouse b-cell2 linker protein blnk 41 c2dlzA_ not modelled 99.9 27 PDB header:signaling protein Chain: A: PDB Molecule:protein vav-2; PDBTitle: solution structure of the sh2 domain of human protein vav-2 42 c2crhA_ not modelled 99.9 29 PDB header:signaling protein Chain: A: PDB Molecule:vav proto-oncogene; PDBTitle: solution structure of the sh2 domain of human proto-2 oncogene protein vav1 43 d1a81a1 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 44 c3or8A_ not modelled 99.9 25 PDB header:transcription Chain: A: PDB Molecule:transcription elongation factor spt6; PDBTitle: a tandem sh2 domain in transcription elongation factor spt6 45 d1a81e1 not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 46 c2dlyA_ not modelled 99.9 38 PDB header:transferase Chain: A: PDB Molecule:fyn-related kinase; PDBTitle: solution structure of the sh2 domain of murine fyn-related2 kinase 47 c2ablA_ not modelled 99.9 28 PDB header:transferase Chain: A: PDB Molecule:abl tyrosine kinase; PDBTitle: sh3-sh2 domain fragment of human bcr-abl tyrosine kinase 48 d2oq1a2 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 49 c2lctA_ not modelled 99.9 30 PDB header:signaling protein Chain: A: PDB Molecule:proto-oncogene vav; PDBTitle: solution structure of the vav1 sh2 domain complexed with a syk-derived2 doubly phosphorylated peptide 50 c2ge9A_ not modelled 99.9 31 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase btk; PDBTitle: solution structures of the sh2 domain of bruton's tyrosine2 kinase 51 d1a81e2 not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 52 d1a81a2 not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 53 c2vifA_ not modelled 99.9 38 PDB header:signaling protein Chain: A: PDB Molecule:suppressor of cytokine signalling 6; PDBTitle: crystal structure of socs6 sh2 domain in complex with a c-kit2 phosphopeptide 54 d2shpa2 not modelled 99.9 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 55 c2gsbA_ not modelled 99.9 24 PDB header:signaling protein Chain: A: PDB Molecule:ras gtpase-activating protein 1; PDBTitle: solution structure of the second sh2 domain of human ras2 gtpase-activating protein 1 56 d1fu6a_ not modelled 99.9 85 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 57 c2eobA_ not modelled 99.9 33 PDB header:hydrolase Chain: A: PDB Molecule:1-phosphatidylinositol-4,5-bisphosphate PDBTitle: solution structure of the second sh2 domain from rat plc2 gamma-2 58 d1csya_ not modelled 99.9 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 59 d1opka2 not modelled 99.9 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 60 d1lkka_ not modelled 99.9 38 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 61 d1qcfa2 not modelled 99.9 36 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 62 d1jwoa_ not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 63 c2ysxA_ not modelled 99.9 29 PDB header:signaling protein Chain: A: PDB Molecule:signaling inositol polyphosphate phosphatase PDBTitle: solution structure of the human ship sh2 domain 64 d1nrva_ not modelled 99.9 24 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 65 d1rjaa_ not modelled 99.9 32 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 66 d1k9aa2 not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 67 c2xp1A_ not modelled 99.9 22 PDB header:transcription Chain: A: PDB Molecule:spt6; PDBTitle: structure of the tandem sh2 domains from antonospora locustae2 transcription elongation factor spt6 68 d2izva2 not modelled 99.9 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 69 c2knoA_ not modelled 99.9 32 PDB header:hydrolase Chain: A: PDB Molecule:tensin-like c1 domain-containing phosphatase; PDBTitle: nmr solution structure of sh2 domain of the human tensin like c12 domain containing phosphatase (tenc1) 70 c2izvA_ not modelled 99.9 20 PDB header:transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 4; PDBTitle: crystal structure of socs-4 in complex with elongin-b and2 elongin-c at 2.55a resolution 71 c1ka6A_ not modelled 99.9 29 PDB header:immune system Chain: A: PDB Molecule:sh2 domain protein 1a; PDBTitle: sap/sh2d1a bound to peptide n-py 72 d1blja_ not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 73 c2eo3A_ not modelled 99.9 28 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of the sh2 domain from human crk-like2 protein 74 c2lqnA_ not modelled 99.9 27 PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structure of crkl 75 c1x6cA_ not modelled 99.9 29 PDB header:signaling protein Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type PDBTitle: solution structures of the sh2 domain of human protein-2 tyrosine phosphatase shp-1 76 d1fhsa_ not modelled 99.9 34 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 77 d1bkla_ not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 78 c2hmhA_ not modelled 99.9 27 PDB header:cytokine regulator Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: crystal structure of socs3 in complex with gp130(ptyr757)2 phosphopeptide. 79 d1g83a2 not modelled 99.9 35 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 80 d1ayaa_ not modelled 99.9 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 81 d1o48a_ not modelled 99.9 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 82 d1luia_ not modelled 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 83 d2qmsa1 not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 84 d3c7ia1 not modelled 99.8 27 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 85 c2augB_ not modelled 99.8 28 PDB header:signaling protein Chain: B: PDB Molecule:growth factor receptor-bound protein 14; PDBTitle: crystal structure of the grb14 sh2 domain 86 d1i3za_ not modelled 99.8 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 87 c3nhnA_ not modelled 99.8 31 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase hck; PDBTitle: crystal structure of the src-family kinase hck sh3-sh2-linker2 regulatory region 88 d1f2fa_ not modelled 99.8 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 89 c2ekxA_ not modelled 99.8 32 PDB header:signaling protein Chain: A: PDB Molecule:cytoplasmic tyrosine-protein kinase bmx; PDBTitle: solution structure of the human bmx sh2 domain 90 d1d4ta_ not modelled 99.8 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 91 d2shpa3 not modelled 99.8 29 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 92 c2hdxB_ not modelled 99.8 21 PDB header:signaling protein Chain: B: PDB Molecule:sh2-b ph domain containing signaling mediator 1 PDBTitle: crystal structure of the src homology-2 domain of sh2-b in2 complex with jak2 ptyr813 phosphopeptide 93 d2cs0a1 not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 94 d2eyva1 not modelled 99.8 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 95 c2c9wA_ not modelled 99.8 25 PDB header:transcription regulation Chain: A: PDB Molecule:suppressor of cytokine signaling 2; PDBTitle: crystal structure of socs-2 in complex with elongin-b and2 elongin-c at 1.9a resolution 96 c2dm0A_ not modelled 99.8 32 PDB header:transferase Chain: A: PDB Molecule:tyrosine-protein kinase txk; PDBTitle: solution structure of the sh2 domain of human tyrosine-2 protein kinase txk 97 d1cwea_ not modelled 99.8 40 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 98 d1r1qa_ not modelled 99.8 33 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 99 c2ci8A_ not modelled 99.8 26 PDB header:translation Chain: A: PDB Molecule:cytoplasmic protein nck1; PDBTitle: sh2 domain of human nck1 adaptor protein - uncomplexed 100 c3mazA_ not modelled 99.8 16 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 1; PDBTitle: crystal structure of the human brdg1/stap-1 sh2 domain in complex with2 the ntal ptyr136 peptide 101 d1mila_ not modelled 99.8 30 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 102 d2fcia1 not modelled 99.8 31 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 103 c1g83A_ not modelled 99.8 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fyn; PDBTitle: crystal structure of fyn sh3-sh2 104 d1xa6a2 not modelled 99.8 28 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 105 c2kk6A_ not modelled 99.8 30 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fer; PDBTitle: solution structure of sh2 domain of proto-oncogene tyrosine-2 protein kinase fer from homo sapiens, northeast structural3 genomics consortium (nesg) target hr3461d 106 c2dcrA_ not modelled 99.8 28 PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase fes/fps; PDBTitle: fully automated solution structure determination of the fes2 sh2 domain 107 d1jyra_ not modelled 99.8 37 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 108 d2c9wa2 not modelled 99.8 26 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 109 c2el8A_ not modelled 99.8 20 PDB header:signaling protein Chain: A: PDB Molecule:signal-transducing adaptor protein 2; PDBTitle: solution structure of the human stap2 sh2 domain 110 c3gxxB_ not modelled 99.8 25 PDB header:transcription Chain: B: PDB Molecule:transcription elongation factor spt6; PDBTitle: structure of the sh2 domain of the candida glabrata2 transcription elongation factor spt6, crystal form b 111 c2cr4A_ not modelled 99.7 26 PDB header:signaling protein Chain: A: PDB Molecule:sh3 domain-binding protein 2; PDBTitle: solution structure of the sh2 domain of human sh3bp2 protein 112 c2dx0B_ not modelled 99.7 35 PDB header:hydrolase Chain: B: PDB Molecule:phospholipase c, gamma 2; PDBTitle: crystal structure of the n-terminal sh2 domain of mouse2 phospholipase c-gamma 2 113 c1rqqC_ not modelled 99.7 28 PDB header:transferase/signaling protein Chain: C: PDB Molecule:adaptor protein aps; PDBTitle: crystal structure of the insulin receptor kinase in complex2 with the sh2 domain of aps 114 d1rpya_ not modelled 99.7 20 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 115 c2eyzA_ not modelled 99.7 30 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform ii 116 c3qwxX_ not modelled 99.7 25 PDB header:signaling protein Chain: X: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 1-174 117 c2dvjA_ not modelled 99.7 37 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog, PDBTitle: phosphorylated crk-ii 118 c2eyyA_ not modelled 99.7 29 PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: ct10-regulated kinase isoform i 119 c3qwyA_ not modelled 99.7 26 PDB header:signaling protein Chain: A: PDB Molecule:cell death abnormality protein 2; PDBTitle: ced-2 120 c2v1yB_ not modelled 99.5 74 PDB header:transferase Chain: B: PDB Molecule:phosphatidylinositol 3-kinase regulatory subunit alpha; PDBTitle: structure of a phosphoinositide 3-kinase alpha adaptor-2 binding domain (abd) in a complex with the ish2 domain3 from p85 alpha