|   |   |
409 | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| . | . | . | . | . | . | . | . | . | . | . | . | . |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
L | L | I | E | R | E | R | N | G | E | A | I | D | R | S | L | L | R | S | L | L | S | M | L | S | D | L | Q | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
I | Y | Q | D | S | F | E | Q | Q | F | L | Q | E | T | N | R | L | Y | A |
| Query Conservation |   |
  |   |
|   |   |   |
|   |
|   |   |
|
|   |   |   |
|   |   |   |   |   |   |
|   |   |
|   | . | . | . | . | . | . | . | . | . | . | . | . | . |   |
|   |   |   |
|
|   |   |   |
|   |   |
|   |   |   |
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |
|   |   |
|   |
|
|   |
|   |
|
| . | . | . |   |   |
|
|   |
|
|   |   |   |
|   |   |
|
|   |   |
|   |   |   |
|   |   |   |   |
|   |   |
|   |   |   |
|
|   |   |
|
|
|   |   |   |
| Template Sequence |   |
E | A | I | Q | K | A | I | R | G | I | G | T | D | E | . |
. |
. |
K | M | L | I | S | I | L | T | E | R | S | N | A | Q | R | Q | L | I | V | K | E | Y | Q | A | A | Y | G | K | E | L | K | D | D | L | K | G | D | L | S | G | H | F | E |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  | S | S | S | S |
|
|  | . | . | . |  |  |  |  |  |  |  | T | T | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S |
|
|  |  |  |  |  |  |  |  |
|
|  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |
|
|
|
|
|  | . | . | . |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
26 | . | . | . | 30 | . | . | . | . | . | . | . | . | . | |
|
|
40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . |
|   |
|   |   |
456 | . | . | . | 460 | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
A | E | G | Q | K | L | M | Q | E | R | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
E | V | P | E | Y | L | H | H | V | N | K | R | L | E | E | E | A | D | R | L | I | T | Y | L | D | Q | T | T | Q | K | S | L | I |
| Query Conservation |   |
  |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |
|
|   |   |   |   |   |   |
|   |   |
|   |   |
|   |   |   |   |
|   |   |   |
|   |   |   |
|   |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
  |   |
|   |   |
|   |   |   |   |   |   |   |
|
|   |   |
|   |   |
|   |
|
|   |
|
|
|
|   |   |
|
|
|
|
|   |   |
|
|   |   |
|   |   |   |
|
|   |
|
|   |   |   |
|   |   |   |
|   |
| Template Sequence |   |
H | L | M | V | A | L | V | T | P | P | A | V | F | D | A | K | Q | L | K | K | S | M | K | G | A | G | T | N | E | D | A | L | I | E | I | L | T | T | R | T | S | R | Q | M | K | D | I | S | Q | A | Y | Y | T | V | Y | K | K | S | L | G |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |
| S | S | S |
|
|  |  |  |  |  |  |  |  |  |  | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S | S |
|  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
83 | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . |
|   |
|   |   |
499 | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
. | . | . | 530 | . | . | . | . | . | . | . | . | . | 540 | . | . | |
|
|
|
|
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
| . | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
| . | . | . | . | . |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
| Query Sequence |   |
A | S | V | E | K | Q | L | L | G | E | H | L | T | A | I | L | Q | K | G | L | N | S | L | L | D | E | N | R | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
I | Q | D | L | S | L | L | Y | Q | L | F | S | R | V | R | G | . |
. |
. |
. |
. |
| Query Conservation |   |
  |   |   |   |   |   |
|
|   |   |   |   |   |   |
|
|   |   |   |   |   |   |
|
|   |   |   |   | . | . | . | . | . | . | . | . | . | . | . |   |   |   |
|   |   |
|
|   |
|   |   |   |   |   |   | . | . | . | . | . |
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
| Template Conservation |   |
  |
|
|   |   |   |   |
|
|   |   |   |   |
| . | . | . | . | . |
|   |   |
|
|   |   |   |
|   |
|   |   |   |
|
|   |   |   |
|   |   |
|
|   |   |
|   |   |
|   |   |   |   |   |
|   |
|
|   |   |
| Template Sequence |   |
D | D | I | S | S | E | T | S | G | D | F | R | K | A | . |
. |
. |
. |
. |
L | L | T | L | A | D | G | R | R | D | E | S | L | K | V | D | E | H | L | A | K | Q | D | A | Q | I | L | Y | K | A | G | E | N | R | W | G | T | D | E | D | K |
| Template Known Secondary structure |   |
 |  |  |  |  |  |
|
|  |  |  |  |  |  | . | . | . | . | . |  |  |  |  |  | T | T |
| S |
|
|
| S |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | T | S | S | S |
|
|  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |
|
|
|  |  |  |  |  | . | . | . | . | . |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
143 | . | . | . | . | . | . | 150 | . | . | . | . | . | . | |
|
|
|
|
. | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . |
|   |
|   |   |
|
|
|
|
|
|
|
|
543 | . | . | . | . | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . |
| Predicted Secondary structure |   |
. | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
| Query SS confidence |   |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
G | V | Q | V | L | L | Q | Q | W | I | E | Y | I | K | A | F | G | S | T | I | V | I | N | P | E | K | D | K | T | M | V | Q | E | L | L | D | F | K | D | K | V | D | H | I | I | D | T | C | F | L | K | N |
| Query Conservation |   |
. | . | . | . | . | . | . | . |   |   |   |   |
|   |   |   |   |   |   |   |
|   |   |   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|   |
|   |   |   |   |   |   |
|   |   |   |   |
|   |   |
|
| Alig confidence |   |
. | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| Template Conservation |   |
  |
|   |
|
|   |   |
|
|   |   |   |
|   |   |
|   |   |   |
|   |   |   |   |
|   |   |
|   |   |   |
|   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| Template Sequence |   |
F | T | E | I | L | C | L | R | S | F | P | Q | L | K | L | T | F | D | E | Y | R | N | I | S | Q | K | D | I | V | D | S | I | K | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
| Template Known Secondary structure |   |
 |  |  |  |  |  |  | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S | S |
|  |  |  |  |  |  | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
198 | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |
|   |   |
595 | . | . | . | . | 600 | . | . | . | . | . | . | . | . | . | 610 | . | . | . | . | . | . | . | . | . | 620 | . | . | . | . | . | . | . | . | . | 630 | . | . | . | . | . | . | . | . | . | 640 | . | . | . | . | . | . | . | . | . | 650 | |
|
|
. |
| Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
|
| Query Sequence |   |
E | K | F | I | N | A | M | K | E | A | F | E | T | F | I | N | K | R | P | N | K | P | A | E | L | I | A | K | Y | V | D | S | K | L | R | A | G | N | K | E | A | T | D | E | E | L | E | K | M | L | D | K | I | M | I | I | . |
. |
. |
F |
| Query Conservation |   |
  |   |
|   |   |   |
|   |   |
|
|   |   |   |
|
|   |   |   |   |   |   |   |
|   |
|
|   |
|   |
|   |   |
|
|   |   |   |
|   |   |   |   |   |
|   |
|   |   |
|   |   |   |   |   |
| . | . | . |
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
| . | . | . |
|
| Template Conservation |   |
  |
|   |
|
|   |   |   |   |
|
|   |   |   |
|   |   |   | . |   |   |
|   |   |   |   |
|   |   |
|   |   |
|
|   |
|   |
|
|
| . | . | . | . | . | . |   |   |   |
|   |
|
|
|
|   |
|   |
|   |
| Template Sequence |   |
G | E | L | S | G | H | F | E | D | L | L | L | A | I | V | N | C | V | . |
R | N | T | P | A | F | L | A | E | R | L | H | R | A | L | K | G | I | G | T | D | . |
. |
. |
. |
. |
. |
E | F | T | L | N | R | I | M | V | S | R | S | E | I |
| Template Known Secondary structure |   |
 |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | S | S | S | S |
|
| . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  | T | T | T |
| Template Predicted Secondary structure |   |
 |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  | . |  |
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
| . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
231 | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | |
. | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
|
270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . |
|   |
|   |   |
652 | . | . | . | . | . | . | . | 660 | . | . | . | . | . | . | . | . | . | 670 | . | . | . | . | . | . | . | . | . | 680 | . | . | . | . | . | . | . | . | . | 690 |
| Predicted Secondary structure |   |
 |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
| Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Query Sequence |   |
R | F | I | Y | G | K | D | V | F | E | A | F | Y | K | K | D | L | A | K | R | L | L | V | G | K | S | A | S | V | D | A | E | K | S | M | L | S | K | L |
| Query Conservation |   |
  |   |
|   |   |
|
|   |
|   |   |   |
|   |   |   |
|
|
|
|
|
|   |   |   |
|   |
|   |
|   |
|   |   |   |
|   |   |
|
| Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Template Conservation |   |
|
|   |   |
|
|   |   |
|   |   |   |
|
|   |   |
|   |   |   |
| . | . |   |   |   |
|
|
|   |
|   |   |   |
|
|   |
|   |
| Template Sequence |   |
D | L | L | D | I | R | T | E | F | K | K | H | Y | G | Y | S | L | Y | S | A | I | . |
. |
K | S | D | T | S | G | D | Y | E | I | T | L | L | K | I | C |
| Template Known Secondary structure |   |
T |  |  |  |  |  |  |  |  |  |  |  |  | S | S |
|  |  |  |  |  | . | . |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |
| Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  | . | . |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |
| Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |   |
284 | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | |
|
. | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 |
|   |