Job Description P14234 Confidence 100.00% Date Wed Jul 10 14:36:25 BST 2013 Rank 200 Aligned Residues 243 % Identity 25% Template c3kvwA_ PDB info PDB header:transferase Chain: A: PDB Molecule:dual specificity tyrosine-phosphorylation-regulated kinase PDBTitle: crystal structure of dual-specificity tyrosine phosphorylation2 regulated kinase 2 (dyrk2) in complex with an indirubin ligand Resolution 2.28 Å

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		249	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.		.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.
Predicted Secondary structure																									.																																	.	.	.	.
Query SS confidence																									.																																	.	.	.	.
Query Sequence		N	S	I	A	L	E	R	R	L	G	T	G	C	F	G	D	V	W	L	G	T	W	N	.	C	S	T	K	V	A	V	K	T	L	K	P	G	T	M	S	P	K	A	F	L	E	E	A	Q	I	M	K	L	L	R	H	.	.	.	.
Query Conservation																									.																																	.	.	.	.
Alig confidence																									.																																	.	.	.	.
Template Conservation
Template Sequence		Y	R	Y	E	V	L	K	V	I	G	K	G	S	F	G	Q	V	V	K	A	Y	D	H	K	V	H	Q	H	V	A	L	K	M	V	R	N	E	K	R	F	H	R	Q	A	A	E	E	I	R	I	L	E	H	L	R	K	Q	D	K	D
Template Known Secondary structure		T	T										S	S	S									T	T	T	T										S																				T	T		T	T
Template Predicted Secondary structure
Template SS confidence
		147	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.
				304	.	.	.	.	.	310	.	.	.	.	.		.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Predicted Secondary structure		.	.													.
Query SS confidence		.	.													.
Query Sequence		.	.	D	K	L	V	Q	L	Y	A	V	V	S	E	.	E	P	I	Y	I	V	T	E	F	M	C	Y	G	S	L	L	D	F	L	K	D	R	E	G	Q	N	L	M	L	P	H	L	V	D	M	A	A	Q	V	A	E	G	M	A	Y
Query Conservation		.	.													.
Alig confidence		.	.													.											.
Template Conservation																											.
Template Sequence		N	T	M	N	V	I	H	M	L	E	N	F	T	F	R	N	H	I	C	M	T	F	E	L	L	.	S	M	N	L	Y	E	L	I	K	K	N	K	F	Q	G	F	S	L	P	L	V	R	K	F	A	H	S	I	L	Q	C	L	D	A
Template Known Secondary structure		S		S		B										T	T										.			B								T	T	T
Template Predicted Secondary structure																											.
Template SS confidence
		207	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.		.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.
		361	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.			.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.
Predicted Secondary structure																								.	.
Query SS confidence																								.	.
Query Sequence		M	E	R	M	N	Y	I	H	R	D	L	R	A	A	N	I	L	V	G	E	Y	L	.	.	I	C	K	I	A	D	F	G	L	A	R	L	I	E	D	N	E	Y	N	P	Q	Q	G	T	K	F	P	I	K	W	T	A	P	E	A	A
Query Conservation																								.	.
Alig confidence																								.	.																								.	.	.	.	.
Template Conservation																																																	.	.	.	.	.
Template Sequence		L	H	K	N	R	I	I	H	C	D	L	K	P	E	N	I	L	L	K	Q	Q	G	R	S	G	I	K	V	I	D	F	G	S	S	C	Y	E	H	Q	R	V	Y	T	I	Q	S	R	.	.	.	.	.	F	Y	R	A	P	E	V	I
Template Known Secondary structure						T				S			S	G	G	G				S	S	T	T	S									T	T				T	T									G	.	.	.	.	.	G	G
Template Predicted Secondary structure																																																	.	.	.	.	.
Template SS confidence
		266	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.						.	.	.	.	.	.	.	320
		419	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.
Predicted Secondary structure																																																		.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																																																		.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		L	F	G	R	F	T	V	K	S	D	V	W	S	F	G	I	L	L	T	E	L	I	T	K	G	R	V	P	Y	P	G	M	N	N	R	E	V	L	E	Q	V	E	H	G	Y	H	M	P	.	.	.	.	.	.	.	.	.	.	.	.
Query Conservation																																																		.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence																									.																									.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																									.
Template Sequence		L	G	A	R	Y	G	M	P	I	D	M	W	S	L	G	C	I	L	A	E	L	L	T	.	G	Y	P	L	L	P	G	E	D	E	G	D	Q	L	A	C	M	I	E	L	L	G	M	P	S	Q	K	L	L	D	A	S	K	R	A	K
Template Known Secondary structure			T	B				T																	.	S	S		S	S			S	S																						T	B	T	T
Template Predicted Secondary structure																									.
Template SS confidence
		322	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.		.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380
																																													467	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.
Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C	P	P	G	C	P	A	S	L	Y	E	V	M	E	Q	A	W
Query Conservation		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		N	F	V	S	K	G	Y	P	R	Y	C	T	V	T	T	L	S	D	V	V	L	N	G	G	R	S	R	R	G	K	L	R	G	P	P	E	S	R	E	W	G	N	A	L	K	G	C	D	D	P	L	F	L	D	F	L	K	Q	C	L
Template Known Secondary structure				B					B	T	T	S																T	T						S	T	T		S						T	T	T														T
Template Predicted Secondary structure
Template SS confidence
		381	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440
		484	.	.	.	.	.	490	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	L	D	P	E	E	R	P	T	F	E	Y	L	Q	S
Query Conservation
Alig confidence
Template Conservation
Template Sequence		E	W	D	P	A	V	R	M	T	P	G	Q	A	L	R
Template Known Secondary structure			S	S	T	T	T	S								T
Template Predicted Secondary structure
Template SS confidence
		444	.	.	.	.	.	450	.	.	.	.	.	.	.	.

No model constructed - rank, confidence too low

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Benjamin Jefferys   Disclaimer Terms and Conditions	Phyre2 is part of Genome3D