Job Description P14234 Confidence 100.00% Date Wed Jul 10 14:36:25 BST 2013 Rank 4 Aligned Residues 433 % Identity 43% Template c1oplA_ PDB info PDB header:transferase Chain: A: PDB Molecule:proto-oncogene tyrosine-protein kinase; PDBTitle: structural basis for the auto-inhibition of c-abl tyrosine2 kinase Resolution 3.42 Å Model Dimensions (Å) X:77.577 Y:72.996 Z:54.306

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		67	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.		.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.
Predicted Secondary structure																																.
Query SS confidence																																.
Query Sequence		V	T	I	F	V	A	L	Y	D	Y	E	A	R	T	G	D	D	L	T	F	T	K	G	E	K	F	H	I	L	N	.	N	T	E	Y	D	W	W	E	A	R	S	L	S	S	G	H	R	G	Y	V	P	S	N	Y	V	A	P	V	D
Query Conservation																																.
Alig confidence																																.												.	.
Template Conservation																																												.	.
Template Sequence		P	N	L	F	V	A	L	Y	D	F	V	A	S	G	D	N	T	L	S	I	T	K	G	E	K	L	R	V	L	G	Y	N	H	N	G	E	W	C	E	A	Q	T	.	.	K	N	G	Q	G	W	V	P	S	N	Y	I	T	P	V	N
Template Known Secondary structure		T	T					S	S		B				S	T	T	B			B		T	T										T	T	S	S							.	.	S	S							G	G	G				S	S
Template Predicted Secondary structure																																												.	.
Template SS confidence
		82	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.			.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.
		126	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	I	Q	A	E	E	W	Y	F	G	K	I	S	R	K	D	A	E	R	Q	L	L	S	S	G	N	P	Q	G	A	F	L	I	R	E	S	E	T	T	K	G	A	Y	S	L	S	I	R	D	W	D	Q	N	R	G	D	H	I	K	H
Query Conservation
Alig confidence																							.	.																											.	.	.	.	.
Template Conservation																							.	.																											.	.	.	.	.
Template Sequence		S	L	E	K	H	S	W	Y	H	G	P	V	S	R	N	A	A	E	Y	L	L	.	.	S	S	G	I	N	G	S	F	L	V	R	E	S	E	S	S	P	G	Q	R	S	I	S	L	R	Y	.	.	.	.	.	E	G	R	V	Y	H
Template Known Secondary structure		S	G	G	G	S	T	T														G	.	.	G	G			T	T								S	S	S	T	T									.	.	.	.	.	T	T
Template Predicted Secondary structure																							.	.																											.	.	.	.	.
Template SS confidence
		140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160			.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.						.	.	.	190	.	.
		186	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.				.	.	.	.	.	.	240	.	.
Predicted Secondary structure																																																		.	.	.
Query SS confidence																																																		.	.	.
Query Sequence		Y	K	I	R	K	L	D	T	G	G	Y	Y	I	T	T	R	A	Q	F	D	S	I	Q	D	L	V	R	H	Y	M	E	V	N	D	G	L	C	Y	L	L	T	A	P	C	T	T	T	K	.	.	.	P	Q	T	L	G	L	A	K	D
Query Conservation																																																		.	.	.
Alig confidence																																																		.	.	.
Template Conservation
Template Sequence		Y	R	I	N	T	A	S	D	G	K	L	Y	V	S	S	E	S	R	F	N	T	L	A	E	L	V	H	H	H	S	T	V	A	D	G	L	I	T	T	L	H	Y	P	A	P	K	R	N	K	P	T	V	Y	G	V	S	P	N	Y	D
Template Known Secondary structure								T	T	S				S	S	T	T	S		B	S	S									T	T			T	T	S	S	S										S					S	S	S		S	S	S	S
Template Predicted Secondary structure
Template SS confidence
		193	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.
		243	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.		.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.
Predicted Secondary structure																																.
Query SS confidence																																.
Query Sequence		A	W	E	I	D	R	N	S	I	A	L	E	R	R	L	G	T	G	C	F	G	D	V	W	L	G	T	W	N	C	.	S	T	K	V	A	V	K	T	L	K	P	G	T	M	S	P	K	A	F	L	E	E	A	Q	I	M	K	L	L
Query Conservation																																.
Alig confidence																																.
Template Conservation
Template Sequence		K	W	E	M	E	R	T	D	I	T	M	K	H	K	L	G	G	G	Q	Y	G	E	V	Y	E	G	V	W	K	K	Y	S	L	T	V	A	V	K	T	L	K	E	D	T	M	E	V	E	E	F	L	K	E	A	A	V	M	K	E	I
Template Known Secondary structure				B			G	G	G							S	G	G	G	T	T	S	S							G	G	G	T										S	S	S	S
Template Predicted Secondary structure
Template SS confidence
		253	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.
		302	.	.	.	.	.	.	.	310	.	.	.	.	.		.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Predicted Secondary structure																.
Query SS confidence																.
Query Sequence		R	H	D	K	L	V	Q	L	Y	A	V	V	S	E	.	E	P	I	Y	I	V	T	E	F	M	C	Y	G	S	L	L	D	F	L	K	D	R	E	G	Q	N	L	M	L	P	H	L	V	D	M	A	A	Q	V	A	E	G	M	A	Y
Query Conservation																.
Alig confidence																.
Template Conservation
Template Sequence		K	H	P	N	L	V	Q	L	L	G	V	C	T	R	E	P	P	F	Y	I	I	T	E	F	M	T	Y	G	N	L	L	D	Y	L	R	E	C	N	R	Q	E	V	N	A	V	V	L	L	Y	M	A	T	Q	I	S	S	A	M	E	Y
Template Known Secondary structure				T	T	B									S	S	S	S									T	T		B								S		T	T	T	S
Template Predicted Secondary structure
Template SS confidence
		313	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.
		361	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Predicted Secondary structure
Query SS confidence
Query Sequence		M	E	R	M	N	Y	I	H	R	D	L	R	A	A	N	I	L	V	G	E	Y	L	I	C	K	I	A	D	F	G	L	A	R	L	I	E	D	N	E	Y	N	P	Q	Q	G	T	K	F	P	I	K	W	T	A	P	E	A	A	L	F
Query Conservation
Alig confidence
Template Conservation
Template Sequence		L	E	K	K	N	F	I	H	R	N	L	A	A	R	N	C	L	V	G	E	N	H	L	V	K	V	A	D	F	G	L	S	R	L	M	T	G	D	T	Y	T	A	H	A	G	A	K	F	P	I	K	W	T	A	P	E	S	L	A	Y
Template Known Secondary structure					T	T				S			S	G	G	G					G	G	G							T	T						T	T							T	T					G	G	G
Template Predicted Secondary structure
Template SS confidence
		373	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.
		421	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Predicted Secondary structure
Query SS confidence
Query Sequence		G	R	F	T	V	K	S	D	V	W	S	F	G	I	L	L	T	E	L	I	T	K	G	R	V	P	Y	P	G	M	N	N	R	E	V	L	E	Q	V	E	H	G	Y	H	M	P	C	P	P	G	C	P	A	S	L	Y	E	V	M	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		N	K	F	S	I	K	S	D	V	W	A	F	G	V	L	L	W	E	I	A	T	Y	G	M	S	P	Y	P	G	I	D	L	S	Q	V	Y	E	L	L	E	K	D	Y	R	M	E	R	P	E	G	C	P	E	K	V	Y	E	L	M	R
Template Known Secondary structure																						T	T	S			S	S	T	T			T	T	T							T	T							T	T
Template Predicted Secondary structure
Template SS confidence
		433	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.
		481	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	A	W	R	L	D	P	E	E	R	P	T	F	E	Y	L	Q	S	F	L	E	D	Y	F	T	S	T	E
Query Conservation
Alig confidence
Template Conservation
Template Sequence		A	C	W	Q	W	N	P	S	D	R	P	S	F	A	E	I	H	Q	A	F	E	T	M	F	Q	E	S	S
Template Known Secondary structure				T		S	S	G	G	G	S												T	S		S	S	S
Template Predicted Secondary structure
Template SS confidence
		493	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520